Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Antigens, CD8
Antigens, Neoplasm
Antigens, CD3
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens, Surface
Antigens, CD38
Antigens, CD34
Antigens, CD19
Antigens, CD40
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD40 Ligand
Antigens, CD20
Antigens, CD28
Antigens, CD44
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, CD7
Antigens, CD14
Antigens, CD2
CD4-CD8 Ratio
Antigens, CD5
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens, Differentiation
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Antigens, CD1
Antigens, CD56
Antigens, Differentiation, T-Lymphocyte
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Antigens, Differentiation, Myelomonocytic
Antigens, CD80
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Antigens, CD53
Antigens, CD24
Antigens, CD13
Antigens, Protozoan
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Antigens, CD86
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
B-Lymphocytes
Antigens, Polyomavirus Transforming
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
Antigens, CD95
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
HLA Antigens
Antigens, Differentiation, B-Lymphocyte
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Immunophenotyping
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Sialic Acid Binding Ig-like Lectin 3
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Antigens, Helminth
Receptors, Antigen, T-Cell
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Antigens, CD18
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Antigens, CD30
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
CD8-Positive T-Lymphocytes
Antigens, CD9
Carcinoembryonic Antigen
HLA-DR Antigens
Antigens, CD15
Antigens, Viral, Tumor
Antigens, CD43
Antigens, CD36
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
Amino Acid Sequence
Antigens, CD11
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Antigens, CD59
Receptors, Antigen, B-Cell
Proliferating Cell Nuclear Antigen
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Antigens, CD57
Antigens, CD70
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
Antigens, CD46
Lectins, C-Type
Antigens, CD58
Antigens, CD4
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
Antigens, CD47
Antigens, CD11b
Base Sequence
Prostate-Specific Antigen
Antigens, CD11c
O Antigens
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
HLA-A2 Antigen
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Immunohistochemistry
CD4 Lymphocyte Count
Immunoglobulin G
Antigens, Tumor-Associated, Carbohydrate
Antigens, CD55
Antigens, CD31
Tumor Cells, Cultured
Histocompatibility Antigens Class I
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Antigens, CD81
Cells, Cultured
Antigens, CD137
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Cell Differentiation
Lymphocytes
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Monocytes
HLA-A Antigens
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Cross Reactions
Dendritic Cells
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors, Interleukin-2
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Blood Group Antigens
Hepatitis B Surface Antigens
Antigens, CD63
Transfection
Antibody Specificity
Antigens, CD151
Antigens, CD79
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
HLA-D Antigens
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
CD30 Ligand
Phenotype
N-Glycosyl Hydrolases
Burkitt Lymphoma
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Receptors, Antigen
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Antibody Formation
Antigens, CD11a
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Hepatitis B Antigens
Bone Marrow
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Antigen-Antibody Reactions
Immune Sera
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice, SCID
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
T-Lymphocytes, Cytotoxic
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant Fusion Proteins
Cell Division
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Herpesvirus 4, Human
Receptors, Antigen, T-Cell, alpha-beta
HLA-B Antigens
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
Immunologic Memory
Bone Marrow Cells
Cytotoxicity, Immunologic
Mice, Transgenic
MART-1 Antigen
Antigens, CD147
HIV Antigens
CTLA-4 Antigen
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Antigens, CD82
Immunoenzyme Techniques
Antibodies
Gene Expression
Antigens, Thy-1
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Immunity, Cellular
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Autoantigens
Clone Cells
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Epstein-Barr Virus Nuclear Antigens
Interleukin-2
Immunoglobulin M
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
H-Y Antigen
Antigens, CD146
Antigens, Heterophile
T-Lymphocytes, Regulatory
Antibodies, Monoclonal, Murine-Derived
Epitopes, T-Lymphocyte
Interferon-gamma
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Antigens, CD98
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
Hepatitis B Core Antigens
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Antigen-Antibody Complex
Lymph Nodes
Immunodiffusion
HLA-DQ Antigens
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Forssman Antigen
Rabbits
Antigens, CD274
Complement Fixation Tests
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
Simian virus 40
Glycoproteins
Adjuvants, Immunologic
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Isoantigens
Hybridomas
gp100 Melanoma Antigen
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Immunoelectrophoresis
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
The haemopoietic growth factor, Flt3L, alters the immune response induced by transcutaneous immunization. (1/629)
Topical application of antigen induces antigen-specific humoral and cellular immune responses. In this study we examined whether expansion of dendritic cells (DC) by Flt3 ligand (Flt3L) treatment influences the induction of immune responses following transcutaneous immunization. Mice were treated intraperitoneally with Flt3L or phosphate-buffered saline (PBS) and immunized transcutaneously with hen egg lysozyme (HEL). Flt3L-treated mice developed lower HEL-specific cellular and humoral immune responses than PBS-treated mice. However, in the presence of cholera toxin (CT), a potent adjuvant for mucosal and transcutaneous immunization, Flt3L-treated mice developed significantly higher cellular and humoral immune responses to HEL when compared to PBS-treated mice. We assessed whether the immunomodulatory effects of CT were a result of activation of epidermal dendritic cells (Langerhans' cells; LC). Our results indicate that within 8-12 hr of topical application of CT, epidermal LC cells lose their dendritic morphology and become rounder in appearance. In addition, we observed enhanced expression of major histocompatibility complex (MHC) class II, and of adhesion molecules CD11c and intracellular adhesion molecule-1 (ICAM-1). Our observations support the concept that the state of activation of DC in the skin is central to the regulation of immune responses. This information is relevant to the design of effective transcutaneous vaccination strategies. (+info)The interplay of dendritic cell subsets in systemic lupus erythematosus. (2/629)
Dendritic cells (DC) control immunity and tolerance. Hence, we surmised that systemic lupus erythematosus (SLE), a systemic autoimmune disease with autoreactive T and B cells, might be due to DC alterations. Based on our findings, we are proposing a model of SLE where autoimmune responses are driven by unabated activation of myeloid DC through IFN-alpha produced by plasmacytoid DC. Thus, interplay between DC subsets might represent a key component of SLE pathogenesis. (+info)Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage. (3/629)
The developmental origin of dendritic cells (DCs) is controversial. In the mouse CD8alpha(+) and CD8alpha(-) DC subsets are often considered to be of lymphoid and myeloid origin respectively, although evidence on this point is conflicting. Very recently a novel CD11c(+) B220(+) DC subset has been identified that appears to be the murine counterpart to interferon alpha (IFNalpha)-producing human plasmacytoid DCs (PDCs). We show here that CD11c(+) B220(+) mouse PDCs, like human PDCs, are present in the thymus and express T lineage markers such as CD8alpha and CD4. However, the intrathymic development of PDCs can be completely dissociated from immature T lineage cells in mixed chimeras established with bone marrow cells from mice deficient for either Notch-1 or T-cell factor 1, two independent mutations that severely block early T-cell development. Our data indicate that thymic PDCs do not arise from a bipotential T/DC precursor. (+info)Myeloid blood CD11c(+) dendritic cells and monocyte-derived dendritic cells differ in their ability to stimulate T lymphocytes. (4/629)
Dendritic cells (DCs) initiate and direct immune responses. Recent studies have defined different DC populations, therefore we undertook this study comparing 2 types of myeloid DCs: blood CD11c(+) DCs and in vitro monocyte-derived DCs (Mo-DCs), which are both candidates as cellular adjuvants for cancer immunotherapy. Blood CD11c(+) DCs were prepared by cell sorting from peripheral blood mononuclear cells cultured overnight in RPMI 1640 medium supplemented with autologous or pooled AB serum. Mo-DCs were prepared in the same medium using granulocyte macrophage-colony-stimulating factor (GM-CSF)/interleukin 4 (IL-4) and differentiated/activated with lipopolysaccharide or monocyte-conditioned medium (ActMo-DCs). Morphologically, differences between the DC preparations were noted both at a light and and electron microscopic level. Blood CD11c(+) DCs expressed similar levels of HLA-DR, CD40, CD86, and CD83 as Mo-DCs. CD209 was present on Mo-DCs but not on blood CD11c(+) DCs. Blood CD11c(+) DCs generated a lower proliferative mixed leukocyte response (MLR) than Mo-DCs. Blood CD11c(+) DCs loaded with 0.1 microg/mL tetanus toxoid (TT)-generated greater T lymphocyte proliferative responses than did Mo-DCs or ActMo-DCs, but when loaded with higher TT concentrations no difference in T lymphocyte proliferative response was observed. Keyhole limpet hemocyanin (KLH)-loaded blood CD11c(+) DCs generated greater T lymphocyte proliferative responses than Mo-DCs or ActMo-DCs. Allogeneic MLR- or KLH-specific responses induced by blood CD11c(+) DCs generated more Th1 effectors than the responses induced by Mo-DCs or ActMo-DCs. These data establish several differences in the properties of blood CD11c(+) DCs, Mo-DCs, and ActMo-DCs, which suggest that blood DCs merit further consideration as DC preparations for clinical programs are evolved. (+info)Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. (5/629)
Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil granulocytes and CD11c(lo) immature dendritic cells (DC) are the primary cells that efficiently capture and transport particulate bacteria to the spleen. In a systemic infection, CD11c(lo) DC, but not neutrophils, provide critical survival signals, which can be inhibited by TACI-Fc, to antigen-specific MZ B cells and promote their differentiation into IgM-secreting plasmablasts. In a local TI response, peritoneal cavity macrophages provide similar support to B1 B-derived Ag-specific blasts. In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses. (+info)Transient induction of cyclin T1 during human macrophage differentiation regulates human immunodeficiency virus type 1 Tat transactivation function. (6/629)
The human immunodeficiency virus type 1 (HIV-1) Tat protein is essential for viral replication and stimulates transcription of the integrated provirus by recruiting the kinase complex TAK/P-TEFb, composed of cyclin T1 (CycT1) and Cdk9, to the viral TAR RNA element. TAK/P-TEFb phosphorylates the RNA polymerase II complex and stimulates transcriptional elongation. In this report, we investigated the regulation of TAK/P-TEFb in primary human macrophages, a major target cell of HIV infection. While Cdk9 levels remained constant, CycT1 protein expression in freshly isolated monocytes was very low, increased early during macrophage differentiation, and, unexpectedly, decreased to very low levels after about 1 week in culture. The kinase activity of TAK/P-TEFb paralleled the changes in CycT1 protein expression. RNA analysis indicated that the transient induction of CycT1 protein expression involves a posttranscriptional mechanism. In transient transfection assays, the ability of Tat to transactivate the HIV long terminal repeat (LTR) in the late differentiated macrophages was greatly diminished relative to its ability to transactivate the HIV LTR in early differentiated cells, strongly suggesting that CycT1 is limiting for Tat function in late differentiated macrophages. Interestingly, lipopolysaccharide, a component of the cell wall of gram-negative bacteria, reinduced CycT1 expression late in macrophage differentiation. These results raise the possibility that regulation of CycT1 expression may be involved in establishing latent infection in macrophages and that opportunistic infection may reactivate the virus by inducing CycT1 expression. (+info)MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. (7/629)
The MUC1 mucin (CD227) is a cell surface mucin originally thought to be restricted to epithelial tissues. We report that CD227 is expressed on human blood dendritic cells (DC) and monocyte-derived DC following in vitro activation. Freshly isolated murine splenic DC had very low levels of CD227; however, all DC expressed CD227 following in vitro culture. In the mouse spleen, CD227 was seen on clusters within the red pulp and surrounding the marginal zone in the white pulp. Additionally, we confirm CD227 expression by activated human T cells and show for the first time that the CD227 cytoplasmic domain is tyrosine-phosphorylated in activated T cells and DC and is associated with other phosphoproteins, indicating a role in signaling. The function of CD227 on DC and T cells requires further elucidation. (+info)Sezary syndrome patients demonstrate a defect in dendritic cell populations: effects of CD40 ligand and treatment with GM-CSF on dendritic cell numbers and the production of cytokines. (8/629)
Sezary syndrome (SzS) is an advanced form of cutaneous T-cell lymphoma associated with involvement of the peripheral blood by malignant T cells. The disease is defined by impaired cell-mediated immunity and the production of interferon-gamma (IFN-gamma) and interleukin-2 (IL-2), possibly as a result of deficient IL-12 production. To understand the mechanism of this impairment, we examined the composition and function of dendritic cells and monocytes in the blood of SzS patients with different levels of peripheral blood tumor burden. Consistent with our previous observations, numbers of monocytes in SzS patients were comparable to numbers observed in healthy donors. In contrast, decreased IL-12 production correlated with a decrease in the numbers of CD11c(+) dendritic cells, which was particularly profound among patients with medium (20%-50% circulating malignant T cells) and high (more than 50% circulating malignant T cells) tumor burden. Furthermore, CD123(+) dendritic cells, major producers of IFN-alpha, were significantly diminished in SzS patients, regardless of the level of tumor burden. Granulocyte macrophage-colony-stimulating factor-treated patients experienced an increase in the number of dendritic cells but not in IFN-alpha or IL-12 production. However, in vitro stimulation of peripheral blood mononuclear cells from SzS patients with rCD40L and IFN-gamma significantly increased the production of IL-12. Thus, our results demonstrate a profound defect in circulating dendritic cells in SzS patients that may contribute to the pathogenesis of the cytokine disorders and to the depressed cellular immunity. Importantly, the ability of rCD40L to potently induce IL-12 production from monocytes and residual dendritic cells of SzS patients could potentially serve as an immune-restorative therapeutic agent. (+info)
Renal Dendritic Cells Stimulate IL-10 Production and Attenuate Nephrotoxic Nephritis | American Society of Nephrology
Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C...
Environmental Noise Exposure Decreased Due to COVID-19 Restrictions, Research Finds - Hearing Review
Airway management in an infant with congenital trismus: the role of retrograde intubation MAHE Digital Repository
Comparative FISH analysis of C-positive regions of chromosomes of wood mice (Rodentia, Muridae, Sylvaemus), Russian Journal of...
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function | JEM
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Immature Renal Dendritic Cells Recruit Regulatory CXCR6+ Invariant Natural Killer T Cells to Attenuate Crescentic GN | American...
Myeloid dendritic cell | definition of Myeloid dendritic cell by Medical dictionary
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Early Myeloid Dendritic Cell Dysregulation is Predictive of Disease Progression in Simian Immunodeficiency Virus Infection |...
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Regulation of the lifespan in dendritic cell subsets.
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Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily. | The Journal of Immunology
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Plasmacytoid dendritic cell
Unlike myeloid dendritic cells, myeloid antigens like CD11b, CD11c, CD13, CD14 and CD33 are not present on pDC surfaces. ... In humans, pDCs exhibit plasma cell morphology and express CD4, HLA-DR, CD123, blood-derived dendritic cell antigen-2 (BDCA-2 ... Villadangos, José A.; Young, Louise (September 2008). "Antigen-Presentation Properties of Plasmacytoid Dendritic Cells". ... which allows the cell to optimize its antigen-presenting abilities. MHC class I on pDC surfaces are able to activate CD8+ T ...
Hairy cell leukemia
The hairy cells are larger than normal and positive for CD19, CD20, CD22, CD11c, CD25, CD103, and FMC7 antigens. (CD103, CD22, ... and CD11c are strongly expressed.) Hairy cell leukemia-variant (HCL-V), which shares some characteristics with B cell ... usually showing a common Human Leukocyte Antigen (HLA) type. The Hairy Cell Leukemia Consortium was founded in 2008 to address ...
Dendritic cell-based cancer vaccine
Dendritic cells (DCs) are antigen presenting cells for the induction of antigen specific T cell response. DC-based ... are derived from myeloid progenitor cells in the bone marrow and are characterized by expression of CD11c. cDCs can be ... The most critical step in vaccination is the effective presentation of cancer antigens to T cells and because of DCs are the ... Non-activated (immature) DCs are usually located in the peripheral non-lymphoid tissues and they can present self-antigens to T ...
Integrin alpha L
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... CD11a has been shown to interact with ICAM-1. CD11c integrin leukocyte adhesion deficiency Cluster of differentiation GRCh38: ... CD11a+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGAL Info with links in the Cell ... CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an ...
B-cell prolymphocytic leukemia
... one of its key identifiers is the absence in expression of the surface antigens CD10, CD11c, CD25, CD103 and cyclin D1 - an ... B-lymphocytes have two responsibilities: Production of antibodies - In response to antigens, B-lymphocytes produce and release ... b-lymphocyte surface antigens CD19, CD20, CD22, CD79a and FMC7, and weak expression of CD5 and CD23. Due to the similarities ... Interactions between antibodies and antigens allow B-lymphocytes to establish cellular memories, otherwise known as immunities ...
Integrin alpha X
CD11c+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . ... CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages ... Bilsland CA, Diamond MS, Springer TA (1994). "The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by ...
CD11
... present on macrophages that is also called Macrophage-1 antigen (CR3) and αMβ2 integrin. CD11c/CD18 also called complement ... For example, LFA1 (CD11a/CD18) short representation of Lymphocyte Function-associated Antigen 1, also called αLβ2 integrin Mac1 ...
List of MeSH codes (D23)
... antigens, cd11a MeSH D23.050.301.264.035.111.049 - antigens, cd11b MeSH D23.050.301.264.035.111.074 - antigens, cd11c MeSH ... antigens, cd11a MeSH D23.101.100.110.111.049 - antigens, cd11b MeSH D23.101.100.110.111.074 - antigens, cd11c MeSH D23.101. ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ... forssman antigen MeSH D23.050.285.018 - antigens, cd24 MeSH D23.050.285.025 - antigens, cd30 MeSH D23.050.285.040 - antigens, ...
T-cell depletion
... specifically those that target self-antigens. One example is antigen-specific CD4+ T cell tolerance, which serves as the ... In a mammary carcinoma model, depletion of CD25+ regulatory T cells increase the amount of CD8+CD11c+PD110, which target and ... However, in some cases, selective CD4+ T cell tolerance provides a unique therapeutic opportunity to maximize self antigen- ... targeted immune and antitumor responses without inducing autoimmunity by incorporating self antigen-independent CD4+ T cell ...
Integrin beta 2
CD18+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGB2 Info with links in the Cell Migration ... The known binding partners of CD18 are CD11a, CD11b, CD11c and CD11d. Binding of CD18 and CD11 results in the formation of ... Huang C, Springer TA (August 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) ... LFA-1 is involved in adhesion and binding to antigen presenting cells through interactions with the surface protein ICAM-1 ...
Outline of immunology
CD18 Macrophage-1 antigen (CR3) - Heterodimer: CD11b / CD18 Integrin alphaXbeta2 (CR4) - Heterodimer: CD11c / CD18 Very late ... Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... T cells Antigen receptor - T cell receptor (TCR) Subunits - [email protected] / [email protected] / [email protected] / [email protected] Co-receptors CD8 (CD8α / CD8β) CD4 ... CD11c) Beta subunits B1 B2 B3 B4 B5 B6 B7 B8 Dimers Cytoadhesin receptor Integrin alpha6beta4 Glycoprotein IIb/IIIa - ...
ILC2
These cells lack antigen specific B or T cell receptor because of the lack of recombination activating gene. ILC2s produce type ... which produced IL-5 and IL-13 in response to IL-25 and expressed MHC class II and CD11c. In 2006, a similar cell population was ... ILC2s are critical for primary responses to local Th2 antigens e.g. helminths and viruses and that is why ILC2s are abundant in ...
List of MeSH codes (D12.776.543)
... antigens, cd11a MeSH D12.776.543.750.705.408.100.150 - antigens, cd11b MeSH D12.776.543.750.705.408.100.200 - antigens, cd11c ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 - antigens, cd79 MeSH D12.776.543.750.705.816.824 - receptors, antigen, t- ... antigens, cd22 MeSH D12.776.543.550.200.124 - antigens, cd24 MeSH D12.776.543.550.200.131 - antigens, cd31 MeSH D12.776.543.550 ... antigens, cd27 MeSH D12.776.543.750.705.852.760.072 - antigens, cd30 MeSH D12.776.543.750.705.852.760.097 - antigens, cd40 MeSH ...
Pancreatic islet macrophage
In terms of expression markers, islet macrophages are positive for; F4/80, CD11b, CD11c, MHC-II, CD64, CD68, LyzM (lysozyme), ... The islet resident macrophage was first identified in 1979 as an antigen-presenting cell (APC), which expresses major ... Calderon, B (2014). "The Central Role of Antigen Presentation in Islets of Langerhans in Autoimmune Diabetes". Curr Opin ... Hume, DA (1984). "The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: ...
Basophil
CD11c−, Gr-1−, NK1.1−, B220−, CD3−, γδTCR−, αβTCR−, α4 and β4-integrin negative. Recently, Heneberg proposed that basophils may ... pollen proteins or helminth antigens. Recent studies in mice suggest that basophils may also regulate the behavior of T cells ...
CD23
The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. The CD11c+ cells in turn present the ... "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18". Immunity ... Antigens which enter the blood stream can be captured by antigen specific IgE antibodies. The IgE immune complexes that are ... "IgE-mediated enhancement of CD4+ T cell responses in mice requires antigen presentation by CD11c+ cells and not by B cells". ...
Follicular lymphoma
CD11c, or CD23 cell surface proteins; genomic analyses reveal that these cells contain t(14:18)(q32:q21.3) translocation (85-90 ... lymphocyte function-associated antigen 3, that is involved in activating T-cells), CDKN2A (encoding p16INK4a and p14arf tumor ... infusion of tisagenlecleucel chimeric antigen receptor T cells (i.e. CAR T cells) (i.e. T cells that have been isolated from ...
TotalSeq™-A0106 anti-mouse CD11c Antibody anti-CD11c - N418
CD11c forms a α,sub,X,/sub,β,sub,2,/sub, heterodimer with β,sub,2,/sub, integrin (CD18). It is primarily expressed on dendritic ... p style=text-align:justify,CD11c is a 150 kD glycoprotein also known as α,sub,X,/sub, integrin, CR4, and p150. ... Antigen References 1. Barclay A, et al. 1997. The Leukocyte Antigen Facts Book Academic Press.. 2. Springer TA. 1994. Cell 76: ... CD11c is a 150 kD glycoprotein also known as αX integrin, CR4, and p150. CD11c forms a αXβ2 heterodimer with β2 integrin (CD18 ...
FITC anti-human CD11c Antibody anti-CD11c - 3.9
CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αX and CR4. ... Antigen References 1. Petty H. 1996. Immunol. Today 17:209.. 2. Springer T. 1994. Cell 76:301.. 3. Ihanus E, et al. 2007. Blood ... CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αX and CR4. CD11c non-covalently associates with ... Clone 3.9 preferentially binds the activated form of CD11c, is specific for the I domain of CD11c, and is able to partially ...
CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens
To activate these CD8(+) T cells, antigen-presenting cells (APCs) must initially acquire tumor cell-associated antigens. The ... major source of tumor antigens is dead tumor cells, but … ... CD11c Antigen / biosynthesis * CD8-Positive T-Lymphocytes / ... To activate these CD8(+) T cells, antigen-presenting cells (APCs) must initially acquire tumor cell-associated antigens. The ... However, tumor antigen-specific CD8(+) T cell activation and subsequent antitumor immunity are severely impaired in mice ...
Regional Distribution of CNS Antigens Differentially Determines T-Cell Mediated Neuroinflammation in a CX3CR1-Dependent Manner ...
5 a,b). Representative images from the brainstem of Cnp-OVA mice depict myeloid cell-T cell clusters stained with CD11c and CD4 ... We show that antigen sampling in the periphery is independent of regional origin of CNS antigens in both male and female mice. ... Systemic antigen sampling by T cells of CNPase and nestin-derived antigens is similar under homeostatic conditions. a, ... These data show that despite similar levels of peripheral antigen sampling, CNS antigen-specific T cells differentially ...
CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes | Nature Medicine
... they recognize antigen on parenchymal cells-presumably parasitized hepatocytes. Therefore, we report an unexpected dichotomy in ... These effector cells, however, no longer require bone marrow-derived antigen-presenting cells for protection; instead, ... In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity ... Radhakrishnan, S., Celis, E. & Pease, L.R. B7-DC crosslinking restores antigen uptake and augments antigen-presenting cell ...
The Importance of Dendritic Cells in Asthma
In human, various lung DCs survey antigen-rich areas to sample and uptake antigen. Endogenous antigens that are created ... The mDCs are phenotypically CD11c+/hi, BDCA1+ (CD1c) and HLA-DR+ (MHC class II) or CD11c+/int, BDCA3+ (CD141) and HLA-DR+.[8] ... Whereas, exogenous antigens, including bacterial antigens, pollen and other allergens, that are taken up through endocytosis or ... Lung pDCs are CD123+ (IL-3 receptor), CD11c−, BDCA2+ (CD303), BDCA4+ (CD304), HLA-DR+ and ILT7 (CD85g) (Figure 1).[8-13] ...
JCI -
Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity. ... under the control of the CD11c (Itgax) promoter (CD11c-DTR-eGFP mice) were used to allow conditional depletion of DCs. As CD11c ... CD11c-Cre+/- Ido1fl/fl mice) or control littermates (CD11c-Cre-/- Ido1fl/fl) (n = 4-6). Data are expressed as mean ± SEM. **P ... Of note, it was found that Ido1 mRNA expression was higher in CD11c+ cells when compared with CD11c- cells in sham-operated ...
JCI -
IgE in asthma and atopy: cellular and molecular connections
After antigen encounter and TCR activation, they also express CD40L, and thus are able to provide B cells with both of the ... Another dendritic cell type, derived by culture of plasmacytoid CD4+CD3-CD11c- cells with IL-3, is also an efficient Th2 ... Antigen presentation by B cells favors Th2 responses. The local production of IL-4 in the bronchial mucosa by multiple cell ... Antigen presentation in the asthmatic lung: initiation of Th2 responses in the atopic bronchial mucosa.. Superimposed upon the ...
Lisa Zaba, MD, PhD's Profile | Stanford Profiles
We have previously identified CD11c(+)-blood dendritic cell antigen (BDCA)-1(+) cells as the main resident dermal DC population ... Staining for the CD11c integrin, which is abundant on many kinds of DCs, revealed cells in the upper dermis. These cells were ... A second major population of cells located throughout the dermis was positive for factor XIIIA (FXIIIA), but lacked CD11c and ... Dendritic cells (DCs) are a heterogeneous group of antigen-presenting leukocytes that are important in activation of both the ...
CD11c/Integrin alpha X Rabbit anti-Human, Polyclonal, Proteintech 20 μL; Unconjugated Products
| Fisher Scientific
CD11c/Integrin alpha X Antibody, 17342-1-AP, from Proteintech. Species Reactivity: Human; Applications: Flow Cytometry, ... CD11C, Integrin alpha X, ITGAX, Leu M5, SLEB6. Host Species. Rabbit. Purification Method. Antigen Affinity Chromatography. ... CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. ... In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes ...
Anti-Hu CD11c APC-Cy™7 - EXBIO Antibodies
Exbio - Research products - Antibodies - CD and related antigens - Anti-Hu CD11c APC-Cy™7 ... Antigen description CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed ... CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 ... Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE: CD11c/CD18: novel ligands and a role in ...
Macrophage-Mediated Inflammation and Disease: A Focus on the Lung
The lung is exposed to a vast array of inhaled antigens, particulate matter, and pollution. Cells present in the airways must ... and inflammatory monocytes (CD11c−MHCII−CD11b+) [3]; cells of lymphoid origin are sparse as monocyte-derived cells dominate. In ... M. J. Clark, J. Gagnon, A. F. Williams, and A. N. Barclay, "MRC OX-2 antigen: a lymphoid/neuronal membrane glycoprotein with a ... The second and third most common cell types in the airways (and the dominant immune cells in the lung tissue) are DC (CD11c+ ...
Autograft mediated adoptive immunotherapy of cancer in the context of autologous stem cell transplantation
Dendritic cells (DC) are the antigen-presenting cells required for priming of naïve T-cells. DCs that express CD11c are ... have a CD11c-/CD123+ phenotype; they are the precursors of lymphoid DCs and serve to stimulate antigen naïve CD4+CD45RA+ T ... Third, by destroying the tumor, HDC might release tumor antigens that the infused DC1 can recognize and thus primed infused ... The infused autograft immune effectors cells include dendritic cells (DCs) that can recognize tumor antigens to priming infused ...
Malariapigment Hemozoin und die funktionelle Hemmung von Monozyten
The intercellular adhesion molecule 1 (CD54) as well as the p150,95 integrin (CD11c) are decreased on the surface of monocytes ... Finally , the expression of membrane antigens involved in the immune response is decreased in hemozoin-loaded monocytes. The ... Sowohl das Interzelluläre Adhäsionsprotein 1 (CD54) als auch p150,95 Integrin (CD11c) sind in Hemozoin-haltigen Monozyten ... that is responsible for presentation of external antigens, is abrogated in hemozoin-loaded monocyte. ...
Characterization of multiple soluble immune checkpoints in individuals with different Mycobacterium tuberculosis infection...
BTLA-expressing CD11c antigen presenting cells in patients with active tuberculosis exhibit low capacity to stimulate T cell ... Jiang J, Wang X, Wang X, Cao Z, Liu Y, Dong M, Tong A, Cheng X. Reduced CD27 expression on antigen-specific CD4+ T cells ... CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens. Immunity. 2015;42(3):471- ... cytotoxic T-lymphocyte associated antigen 4 (CTLA-4)- CD80. Intracellular molecules, such as indoleamine 2,3-dioxygenase (IDO) ...
Brilliant Violet 421 anti-human CD11c Antibody anti-CD11c - S-HCL-3
CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. ... Antigen References 1. Petty HR, Todd RF 3rd. 1996. Immunol. Today 17:209.. 2. Springer T. 1994. Cell 76:301.. 3. Ihanus E, et ... View All CD11c Reagents Request Custom Conjugation Description. Clone. Applications. Purified anti-human CD11c. S-HCL-3. FC, ... CD11c is a 145-150 kD type I transmembrane glycoprotein also known as integrin αx and CR4. CD11c non-covalently associates with ...
Immunization with Wild-Type p53 Gene Sequences Coadministered with Flt3 Ligand Induces an Antigen-specific Type 1 T-Cell...
It has been reported that Flt3L administration enhances the CD11chighCD11blow type DC, which leads to an Ag-specific, type 1 T- ... studies with the model tumor antigen β-galactosidase and the BALB/c Meth A p53 tumor-specific antigen. Gene Ther. ... Theobald M., Biggs J., Dittmer D., Levine A. J., Sherman L. A. Targeting p53 as a general tumor antigen. Proc. Natl. Acad. Sci ... Maecker H. T., Umetsu D. T., DeKruyff R. H., Levy S. Cytotoxic T cell responses to DNA vaccination: dependence on antigen ...
Type I interferon dependence of plasmacytoid dendritic cell activation and migration | Journal of Experimental Medicine |...
Mouse CD11chigh cDCs have been further subdivided in subsets (5). The nature of the T cell response on presentation of antigen ... pDC were gated as 120G8+CD11clow cells. CD11chigh DC were gated as 120G8−CD11chigh cells. Dot plots shown for each staining are ... pDC were gated as 120G8+CD11clow cells. CD11chigh DC were gated as 120G8−CD11chigh cells. Dot plots shown for each staining are ... In response to LPS, resiquimod, or CpG-ODN treatment in vivo, both CD8α− CD11chigh and CD8α+ CD11chigh subsets of cDCs from WT ...
Mouse Anti-Human CD11c [+FITC] [DS-MB-00277]
Future perspectives in melanoma research. Meeting report from the "Melanoma Bridge. Napoli, December 2nd-4th 2012" | Journal of...
Specific human leukocyte antigen (HLA) class I and II antigens (eg., HLA-A1, HLA-A11, HLA-Cw7, and HLA-DQ1), have previously ... Clinical responders had significantly greater increases in endotumoral CD11c+ and CD3+ cells compared with non responders. No ... Examples of tumor antigens similar to MAGE-A3 include other Cancer/Testis antigens such as NY-ESO-1 and frequently mutated ... which enhance the cytotoxic function of HLA class I antigen restricted, tumor antigen-specific T cells in vitro as well as with ...
Clin Cancer Res | ГастроПортал
Most lineage-negative HLA-DR+ cells expressed CD45RA or CD4 antigens. Dendritic cells had low proportions of CD80, CD11c, ... Dendritic cells, a population of antigen-presenting cells, have been identified as lineage-negative human leukocyte antigen ( ... This study shows that core CD44 and v6 splice variant antigens are differentially expressed in the epithelium and stroma of ... The characteristics of antigen-presenting cells in carcinomas that involve the abdominopelvic cavity are unknown. ...
DeCS 2018 - Changed terms
Antigens, CD11b. CD11b Antigen. Antigens, CD11c. CD11c Antigen. Antigens, CD137. Tumor Necrosis Factor Receptor Superfamily, ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD11b. CD11b Antigen. Antigens, CD11c. CD11c Antigen. Antigens, CD137. Tumor Necrosis Factor Receptor Superfamily, ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD11b. CD11b Antigen. Antigens, CD11c. CD11c Antigen. Antigens, CD137. Tumor Necrosis Factor Receptor Superfamily, ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
DeCS 2018 - Changed terms
Antigens, CD11b. CD11b Antigen. Antigens, CD11c. CD11c Antigen. Antigens, CD137. Tumor Necrosis Factor Receptor Superfamily, ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...
cis-Khellactone Inhibited the Proinflammatory Macrophages via Promoting Autophagy to Ameliorate Imiquimod-Induced Psoriasis -...
... especially CD11c-positive M1 macrophages (Figure 3). CD11c was a well-known surface marker for dendritic cells, but it was also ... Paraffin-embedded skin sections were heat-fixed, deparaffinized, rehydrated, antigen retrieved, blocked with 3% goat serum, and ... c) CD11c and (e) p-p65 expression levels were quantified and expressed as a histogram of mean ± standard deviation of five ... Cell nuclei was stained with DAPI (blue). (b) CD11c and (d) p-p65 expression levels in skin were detected by ...
Code System Concept
CD11c - Cluster of differentiation antigen 11c Active Synonym false false 494695014 p-150,95 - Protein 150,95 Active Synonym ... CD11c - cluster of differentiation antigen 11c Active Synonym false false 3744774011 CRIV - complement receptor IV Active ... Leu-M5 antigen Active Synonym false false 3744773017 ... CD11c/CD18 Active Synonym false false 494697018 p150,95 Active ... Lymphocyte antigen CD11c (substance). Code System Preferred Concept Name. Lymphocyte antigen CD11c (substance). ...
IMSEAR at SEARO: Hairy cell leukemia-variant--a case report.
IntegrinCD11bMacrophagesAntibodyDendriticCellsCD80P150MyeloidCD11DifferentiationCytotoxic T-lymphocyMonocytesReceptorMelanoma AntigenLymphocytesGranulocytesImmunePeripheralProteinPhagocytosisCloneLigandsAdjuvantLungPresentationAntibodiesPeptideComplementGenePhenotypeInfectionMiceUptakeExpressionIC3bAnimalsSpecies
Integrin8
- CD11c is a 150 kD glycoprotein also known as α X integrin, CR4, and p150. (biolegend.com)
- CD11c forms a α X β 2 heterodimer with β 2 integrin (CD18). (biolegend.com)
- CD11c non-covalently associates with integrin β2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. (biolegend.com)
- The antibody BU15 reacts with an extracellular epitope of CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages. (exbio.cz)
- CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. (exbio.cz)
- Sowohl das Interzelluläre Adhäsionsprotein 1 (CD54) als auch p150,95 Integrin (CD11c) sind in Hemozoin-haltigen Monozyten vermindert Oberflächen-exprimiert. (hu-berlin.de)
- CD18(A270V) supports, at a diminished level, CD11b/CD18 (Mac-1, alphaMbeta2 integrin) and CD11c/CD18 (p150,95, alphaXbeta2 integrin) expression and function but not CD11a/CD18 (LFA-1, alphaLbeta2 integrin) expression. (ox.ac.uk)
- In the absence of IRF5, CD11c- macrophages displayed a significant increase in expression of the efferocytosis-regulating integrin-β3 and its ligand milk fat globule-epidermal growth factor 8 protein and enhanced efferocytosis in vitro and in situ. (ox.ac.uk)
CD11b4
- On the other hand, type II mDCs in mice are CD103 − , CD11b + and CD11c + , and express sialoglycoprotein, CD24. (medscape.com)
- In particular, CD11 is composed of CD11a, CD11b and CD11c. (fishersci.no)
- CD18(C590R) and CD18(R593C) show a decreasing capacity to associate with the CD11a, CD11c and CD11b subunits. (ox.ac.uk)
- The expression and function of murine FcgammaR in these CD11c+CD11b-B220+ plasmacytoid DCs was investigated. (dc-research.eu)
Macrophages7
- Here we show that CD169(+) macrophages phagocytose dead tumor cells transported via lymphatic flow and subsequently crosspresent tumor antigens to CD8(+) T cells. (nih.gov)
- However, tumor antigen-specific CD8(+) T cell activation and subsequent antitumor immunity are severely impaired in mice depleted with CD169(+) macrophages. (nih.gov)
- Thus, we have identified CD169(+) macrophages as lymph node-resident APCs dominating early activation of tumor antigen-specific CD8(+) T cells. (nih.gov)
- CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. (fishersci.no)
- Monocyte numbers peak on day 5 after influenza infection as the cells upregulate CD11c and MHC class II, before differentiating into either macrophages or monocyte-derived DC [ 3 ]. (hindawi.com)
- Moreover, we revealed that the CD11c gene is a direct target of IRF5 in macrophages. (ox.ac.uk)
- The early phase of lung innate immune response to many pathogens is characterized by onset of inflammation mediated by phagocytic cells, i.e ., polymorphonuclear leukocytes (PMNs), alveolar macrophages (AM), and antigen presenting dendritic cells (DC) populating the lungs. (cdc.gov)
Antibody5
- Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD11c (BU15) APC-Cy™7 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
- Separation of human monocytes (red-filled) from CD11c negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD11c (BU15) APC-Cy™7 antibody (4 μl reagent / 100 μl of peripheral whole blood). (exbio.cz)
- As the infection resolved, Tbet + CD11c + B cells localized to the marginal zone where splenic retention depended on integrins LFA-1 and VLA-4, forming a competitive memory subset that contributed to antibody production and secondary GC seeding upon rechallenge. (wustl.edu)
- In addition, neutralizing GM-CSF modulates the functions of lung cDC2 that result in diminished antigen specific CD4+ T cell driven antibody response thus effecting flagellin's mucosal adjuvanticity. (europa.eu)
- antibody responses to polysaccharide antigens are decreased and antibody responses to protein antigens are slightly reduced. (medscape.com)
Dendritic7
- Neither migratory dendritic cells (DCs) nor lymph node-resident conventional DCs are essential for the crosspresentation of tumor antigens. (nih.gov)
- The absence of Ag-specific CTLs was attributed to a deficiency in lymphoid CD11c + CD8 + dendritic cells (DCs) in the lower respiratory lymph nodes (LRLNs). (aai.org)
- There are several ways a dendritic cell can be loaded with an antigen. (miltenyibiotec.com)
- Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses. (ox.ac.uk)
- In mice GFP expression was detected in splenic dectin-2(+) cells after intravenous injection and in CD11c(+) dendritic cells in the draining lymph node after subcutaneous injection. (ox.ac.uk)
- As immunization with the optimal dose of the dectin-2 lentivector was similar to that stimulated by a lentivector containing a strong constitutive viral promoter, targeting antigen expression to dendritic cells can provide a safe and effective vaccine. (ox.ac.uk)
- This study by MatTek scientists demonstrated that MatTek's Human Dendritic Cells are an excellent in vitro model for use in a wide variety of studies related to allergenicity, microbial infection and transmission, neutralizing antibodies and anti-microbial agents, antigen capture and presentation, innate immunity and immuno-therapy. (mattek.com)
Cells33
- To activate these CD8(+) T cells, antigen-presenting cells (APCs) must initially acquire tumor cell-associated antigens. (nih.gov)
- The major source of tumor antigens is dead tumor cells, but little is known about how APCs in draining lymph nodes acquire and crosspresent these antigens. (nih.gov)
- T cells continuously sample CNS-derived antigens in the periphery, yet it is unknown how they sample and respond to CNS antigens derived from distinct brain areas. (jneurosci.org)
- We expressed ovalbumin (OVA) neoepitopes in regionally distinct CNS areas (Cnp-OVA and Nes-OVA mice) to test peripheral antigen sampling by OVA-specific T cells under homeostatic and neuroinflammatory conditions. (jneurosci.org)
- These data show that despite similar levels of peripheral antigen sampling, CNS antigen-specific T cells differentially influence neuroinflammatory disease depending on the location of cognate antigens and the presence of CX3CL1/CX3CR1 signaling. (jneurosci.org)
- Altogether, we propose a novel mechanism for how T cells respond to regionally distinct CNS derived antigens and contribute to CNS autoimmune pathology. (jneurosci.org)
- instead, they recognize antigen on parenchymal cells-presumably parasitized hepatocytes. (nature.com)
- Angel CE, Lala A, Chen CJ, Edgar SG, Ostrovsky LL, Dunbar PR: CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts. (exbio.cz)
- The distinct environment of the lung, with high oxygen tension [ 1 ] and constant exposure to inhaled antigen, both harmful and harmless, presents challenges for the immune cells which patrol the airways. (hindawi.com)
- Immune checkpoint proteins can regulate the immune response in malignancies and infectious diseases via numerous types of activating and inhibitory signals between antigen-presenting cells (APCs) and T cells [ 3 , 4 ]. (biomedcentral.com)
- Receptor-ligand interaction is required for the transduction of second signal, following the first signal conveyed by the interaction of MHC molecules on APCs and T cell receptors on effector T cells loaded with cognate antigens [ 3 ]. (biomedcentral.com)
- The antigen is also expressed by hairy cell leukaemia cells. (raybiotech.com)
- The immunophenotype shows a mature B-cell phenotype with expression of B-cell antigens CD11c and CD103 but unlike typical hairy cell the cells are negative for CD25. (who.int)
- Tbet + CD11c + B cells arise during type 1 pathogen challenge, aging, and autoimmunity in mice and humans. (wustl.edu)
- In acute infection, T follicular helper (Tfh) cells, but not Th1 cells, drove Tbet + CD11c + B cell generation through proximal delivery of help. (wustl.edu)
- Tbet + CD11c + B cells developed prior to germinal center (GC) formation, exhibiting phenotypic and transcriptional profiles distinct from GC B cells. (wustl.edu)
- Fate tracking revealed that most Tbet + CD11c + B cells developed independently of GC entry and cell-intrinsic Bcl6 expression. (wustl.edu)
- Tbet + CD11c + and GC B cells exhibited minimal repertoire overlap, indicating distinct developmental pathways. (wustl.edu)
- Therefore, Tbet + CD11c + B cells comprise a GC-independent memory subset capable of rapid and robust recall responses. (wustl.edu)
- 1. Mucosal adjuvant activity of flagellin is dependent on Tlr5 signaling and antigen specific CD4+T cells. (europa.eu)
- We found that antigen specific CD4 T cells that reside in the lung draining is essential to mediate flagellin's adjuvanticity (Fig. 1). (europa.eu)
- METHODS: Human peripheral blood mononuclear cells (PBMCs) were stimulated in vitro with HDI-albumin conjugates or control antigen, and changes in phenotype, gene and protein expression were characterized by flow cytometry, microarray, Western blot and ELISA. (cdc.gov)
- Activated MLKL correlated with increased presence of CD11c antigen presenting cells in -associated submucosa. (pasteur.fr)
- Most likely CD11c+CD103+ and Foxp3+ regulatory T-cells contribute to these protective effects. (uu.nl)
- [ 3 ] Thus, it enhances and prolongs antigen signaling on B cells. (medscape.com)
- Bone marrow (BM) cells became CD86 and CD11c positive within 48 h of treatment with JgD or JH. (omeka.net)
- Efficient loading of DCs with antigens is key for antigen presentation to T cells. (miltenyibiotec.com)
- Patients had significantly fewer circulating myeloid (CD11c+DC) and lymphoid (CD123+DC) DC, and a concurrent accumulation of CD11c CD123 immature cells which expressed high levels of HLA-DR (DR+IC). (edu.au)
- Although DR+IC exhibited limited expression of markers ascribed to mature hematopoietic lineages, expression of HLA-DR, CD40 and CD86 suggested a role as antigen presenting cells. (edu.au)
- We evaluated the capacity of autologous DC and HEK293 cells transfected with relevant HLA alleles to function as T cell targets in Elispot assays upon transfection with tumor antigen encoding plasmids. (dc-research.eu)
- Due to strong background from the autologous DC we decided that HEK293 transfected with one HLA-allele at a time plus simultaneously transfected with up to 5 tumor antiges would be optimal to screen for antigen specificity in the patients T cells. (dc-research.eu)
- To improve safety while retaining efficacy, we constructed a lentivector in which transgene expression was restricted to antigen-presenting cells using the mouse dectin-2 gene promoter. (ox.ac.uk)
- We now demonstrate using a syngeneic mouse tumor model, expressing an Ag derived from the early region 1A of human adenovirus type 5, that the inadequate nature of the antitumor CTL response is not due to direct Ag presentation by the tumor cells, but results from presentation of tumor-derived Ag by nonactivated CD11c(+) APC. (cnrs.fr)
CD802
- Its ability to secrete high levels of IL-12p40, and express high levels of co-stimulatory molecules, including CD80, postulates its role in antigen presentation to T-lymphocytes. (medscape.com)
- Altered expressions of peripheral CD11c, CD80, CD83 markers and associations of HLA class II allele and haplotypes in self-limiting Hepatitis E infection. (cdc.gov)
P1501
- Bullard DC, Hu X, Adams JE, Schoeb TR, Barnum SR: p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis. (exbio.cz)
Myeloid2
- The antigen expressions by immunophenotype in acute myeloid and lymphoblastic leukemias were compared with age, Haemoglobin, Total WBC count, Platelet counts, Lactate dehydrogenase levels and abnormal karyotypes. (imedpub.com)
- CD123+CD11c-) and myeloid DC (mDC, CD123-CD11c+). (mattek.com)
CD111
- Conversely, CD18(A341P) supports a limited level of expression and function of CD11a/CD18, but not of the other two CD11/CD18 antigens. (ox.ac.uk)
Differentiation1
- Distinct dynamics of antigen-specific induction and differentiation of different CD11c + Tbet + B-cell subsets. (bvsalud.org)
Cytotoxic T-lymphocy1
- Recipient cytotoxic T lymphocyte antigen-4 +49 G/G genotype is associated with reduced incidence of hepatitis B virus recurrence after liver transplantation among Chinese patients. (cdc.gov)
Monocytes1
- Finally , the expression of membrane antigens involved in the immune response is decreased in hemozoin-loaded monocytes. (hu-berlin.de)
Receptor1
- Lung pDCs are CD123 + (IL-3 receptor), CD11c − , BDCA2 + (CD303), BDCA4 + (CD304), HLA-DR + and ILT7 (CD85g) (Figure 1). (medscape.com)
Melanoma Antigen1
- A dectin-2 lentivector encoding the human melanoma antigen NY-ESO-1 primed an NY-ESO-1-specific CD8(+) T-cell response in HLA-A2 transgenic mice and stimulated a CD4(+) T-cell response to a newly identified NY-ESO-1 epitope presented by H2 I-A(b). (ox.ac.uk)
Lymphocytes5
- Endogenous antigens that are created intracellularly, including viral and tumor antigens, are processed by DCs and presented via MHC class I molecules to CD8 + T-lymphocytes. (medscape.com)
- Whereas, exogenous antigens, including bacterial antigens, pollen and other allergens, that are taken up through endocytosis or phagocytosis are presented via MHC class II molecules to polarize CD4 + T helper lymphocytes. (medscape.com)
- The main function of these mDCs is to take up the antigens and transfer them to lymph node DCs for communicating with CD4 + T-lymphocytes. (medscape.com)
- They are found under the basement membrane of submucosa, and are major APCs in the uptake and processing of the antigens to prime and stimulate CD4 + T-lymphocytes. (medscape.com)
- Nevertheless, DR+IC had a reduced capacity to capture antigen and elicited poor proliferation and IFN-g secretion by T-lymphocytes. (edu.au)
Granulocytes2
- Human peripheral blood granulocytes were stained with CD11c (clone 3.9) FITC (filled histogram) or mouse IgG1, κ FITC isotype control (open histogram). (biolegend.com)
- Human peripheral blood granulocytes were stained with CD11c (clone S-HCL-3) Brilliant Violet 421™ (filled histogram) or mouse IgG2b, κ Brilliant Violet 421™ isotype control (open histogram). (biolegend.com)
Immune3
- The immature status of the immune system combined with a "leaky" immature gut is considered a risk factor to develop immune reactivity to food antigens when introduced too early in life. (uu.nl)
- On the other hand, antigens provided via the oral route are important for the maturation and training of the mucosal immune system. (uu.nl)
- Lentivectors stimulate potent immune responses to antigen transgenes and are being developed as novel genetic vaccines. (ox.ac.uk)
Peripheral1
- The peripheral blood and bone marrow were tested for surface membrane, cytoplasmic and nuclear antigens and were classified by the French-American- British (FAB) Cooperative Group Classification by using Romanowsky (Leishman and May Grunwald Giemsa[MGG]) stained smears and cytochemical stains. (imedpub.com)
Protein4
- for example, AMs express high CD11c, owing to the high GM-CSF and surfactant protein D levels in the alveoli [ 11 ], which is not seen elsewhere, and which may aid the AM in their phagocytic function. (hindawi.com)
- Our experiments at this direct level indicate that a synthetic TLR4 agonist, GLA-SE, serves as an effective adjuvant and enhances MLN0128 mw the capacity of DCs in vivo to immunize against protein antigens. (peptidesprice.com)
- In the current study, we demonstrated that GLA-SE injection together with a protein antigen allows the antigen-capturing DCs to quickly become immunogenic in vivo. (peptidesprice.com)
- Severity of EAU was assessed in DBA1 and 129/CD1 wild-type (WT) or IL-18 knockout (KO) mice after immunization with the uveitogenic antigen: interphotoreceptor retinal binding protein (IRBP) peptide 161-180. (arvojournals.org)
Phagocytosis1
- Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. (exbio.cz)
Clone1
- Clone 3.9 preferentially binds the activated form of CD11c, is specific for the I domain of CD11c, and is able to partially block the binding of CD11c and ICAM-4. (biolegend.com)
Ligands2
- Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE: CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity. (exbio.cz)
- Ligands for CD11c are ICAM-1, iC3b, and fibrinogen. (raybiotech.com)
Adjuvant2
- To understand adjuvant action, these agonists need to be characterized in vivo at the level of antigen presenting DCs. (peptidesprice.com)
- NP given to the lung along with antigens displayed adjuvant properties and enhanced respiratory and systemic allergic responses. (cdc.gov)
Lung3
- In human, various lung DCs survey antigen-rich areas to sample and uptake antigen. (medscape.com)
- The lung is exposed to a vast array of inhaled antigens, particulate matter, and pollution. (hindawi.com)
- Pan DCs can be isolated from dissociated tissues such as spleen, lung, or lamina propria using CD11c MicroBeads UltraPure. (miltenyibiotec.com)
Presentation5
- The induction of the major histocompatibility complex (MHC) class II by interferon-gamma, that is responsible for presentation of external antigens, is abrogated in hemozoin-loaded monocyte. (hu-berlin.de)
- After 4 h, splenic DCs were purified by cell sorting and injected into naïve mice i.v. In addition, to check that antigen presentation was performed by the transferred and not recipient DCs, MHCII−/− DCs were used as negative controls. (peptidesprice.com)
- The Ligand Epitope Antigen Presentation System (LEAPS) converts a peptide containing a T cell epitope as small as 8 amino acids into an immunogen and directs the nature of the subsequent response. (omeka.net)
- In conclusion, the generated DC alone or the DC containing in vitro engineered tissue models will likely be useful in a variety of studies related to: 1) allergenicity, 2) microbial infection and transmission, 3) neutralizing antibodies and anti-microbial agents, 4) antigen capture and presentation, 5) innate immunity, and 6) immuno-therapy. (mattek.com)
- The latter are mobilized and recruited into inflammation sites where they serve their primary duty - antigen recognition, capture and subsequent presentation. (cdc.gov)
Antibodies1
- Atopy, meaning "strange disease," was used by Coca to describe antigen-specific reactions with apparent immunological specificity for which no precipitating antibodies could be identified in plasma. (jci.org)
Peptide2
- Plus, our PepTivator® Technology provides the peptide pools for antigen loading . (miltenyibiotec.com)
- By using PepTivator® Peptide Pools, antigen loading has never been easier. (miltenyibiotec.com)
Complement1
- CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. (exbio.cz)
Gene2
- The most significant (P-values 0.007-0.05) changes in microarray gene expression were noted in lysosomal genes, especially peptidases and proton pumps involved in antigen processing. (cdc.gov)
- Hairy cell leukemia is recognized as a clonal B-cell malignancy, as identified by immunoglobulin gene rearrangements that result in a phenotype B-cell expression of surface antigens. (medscape.com)
Phenotype2
- The mDCs are phenotypically CD11c + /hi, BDCA1 + (CD1c) and HLA-DR + (MHC class II) or CD11c + /int, BDCA3 + (CD141) and HLA-DR + . [ 8 ] The second major phenotype of DCs is plasmacytoid DCs (pDCs) that can be divided into multiple subtypes, based on location and surface marker expression. (medscape.com)
- In vivo, HDI-exposed subjects exhibited a drastic increase in the percentage of PBMCs with the same HDI-albumin responsive phenotype characterized in vitro (HLA-DR(+)/CD11c(+) with altered light scatter properties). (cdc.gov)
Infection1
- However, the precise site where DCs acquire and present parasite antigen following sporozoite infection through the skin has not been identified. (nature.com)
Mice2
- We show that antigen sampling in the periphery is independent of regional origin of CNS antigens in both male and female mice. (jneurosci.org)
- To further evaluate the capacity of DCs to become immunogenic following antigen capture in vivo, mice were injected with anti-DEC-HIV gag and either GLA-SE or SE. (peptidesprice.com)
Uptake1
- The nature of encountered antigen(s) as well as environmental signals during antigen uptake by DC shape the subsequent T cell response. (cdc.gov)
Expression2
- Many subtypes show characteristic immunophenotypes: Follicular lymphomas show strong surface expression of immunoglobulins and mostly express the antigen CD10, whereas CD5 is not expressed. (mll.com)
- We assessed the role of immunophenotyping and cytogenetics and their clinicopathological correlation with various haematological and biochemical parameters and found a statistically significant correlation with various parameters and supported expression of certain antigens and abnormal karyotypes correlate with a poor prognosis in Acute leukemias. (imedpub.com)
IC3b2
- CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b. (biolegend.com)
- Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b. (exbio.cz)
Animals1
- Intranasal instillation of flagellin increased the proportion of cDC2 among total CD11c+MHCII+ DCs by 35% compared to naïve animals. (europa.eu)
Species1
- 1 It can be induced in many species with uveitogenic retinal antigens. (arvojournals.org)