Theaceae: A plant family of the order THEALES, subclass Dilleniidae, class Magnoliopsida, best known for CAMELLIA SINENSIS, which is the source of Oriental TEA.Quinolinium CompoundsFluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Microglia: The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.HydrazinesAntibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Miller Fisher Syndrome: A variant of the GUILLAIN-BARRE SYNDROME characterized by the acute onset of oculomotor dysfunction, ataxia, and loss of deep tendon reflexes with relative sparing of strength in the extremities and trunk. The ataxia is produced by peripheral sensory nerve dysfunction and not by cerebellar injury. Facial weakness and sensory loss may also occur. The process is mediated by autoantibodies directed against a component of myelin found in peripheral nerves. (Adams et al., Principles of Neurology, 6th ed, p1313; Neurology 1987 Sep;37(9):1493-8)Organic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.Antigens, CD20: Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Monoclonal, Murine-Derived: Antibodies obtained from a single clone of cells grown in mice or rats.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Immunosorbents: An insoluble support for an ANTIGEN or ANTIBODIES that is used in AFFINITY CHROMATOGRAPHY to adsorb the homologous antibody or antigen from a mixture. Many different substances are used, among them SEPHAROSE; GLUTARALDEHYDE; copolymers of ANHYDRIDES; polyacrylamides, etc.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Epitopes: Sites on an antigen that interact with specific antibodies.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Razoxane: An antimitotic agent with immunosuppressive properties.Matrix Attachment Regions: Regions of the CHROMATIN or DNA that bind to the NUCLEAR MATRIX. They are found in INTERGENIC DNA, especially flanking the 5' ends of genes or clusters of genes. Many of the regions that have been isolated contain a bipartite sequence motif called the MAR/SAR recognition signature sequence that binds to MATRIX ATTACHMENT REGION BINDING PROTEINS.Matrix Attachment Region Binding Proteins: Proteins that bind to the MATRIX ATTACHMENT REGIONS of DNA.Nuclear Matrix: The residual framework structure of the CELL NUCLEUS that maintains many of the overall architectural features of the cell nucleus including the nuclear lamina with NUCLEAR PORE complex structures, residual CELL NUCLEOLI and an extensive fibrogranular structure in the nuclear interior. (Advan. Enzyme Regul. 2002; 42:39-52)Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Cell Adhesion: Adherence of cells to surfaces or to other cells.Antigens, CD29: Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)Paraffin Embedding: The infiltrating of tissue specimens with paraffin, as a supporting substance, to prepare for sectioning with a microtome.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Paraffin: A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.Tissue Fixation: The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.Frozen Sections: Thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.Laboratory Animal Science: The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.Laser Scanning Cytometry: A scanning microscope-based, cytofluorimetry technique for making fluorescence measurements and topographic analysis on individual cells. Lasers are used to excite fluorochromes in labeled cellular specimens. Fluorescence is detected in multiple discrete wavelengths and the locational data is processed to quantitatively assess APOPTOSIS; PLOIDIES; cell proliferation; GENE EXPRESSION; PROTEIN TRANSPORT; and other cellular processes.Sheep: Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.Sheep Diseases: Diseases of domestic and mountain sheep of the genus Ovis.Pupil Disorders: Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
Does soluble intercellular adhesion molecule-1 (ICAM-1) affect neutrophil activation and adhesion following ischaemia-reperfusion? (1/437)OBJECTIVES: To examine the effect of reperfusion plasma and sICAM-1 on neutrophil integrin expression and neutrophil adhesion to determine if sICAM-1 has a potential role in the regulation of neutrophil adhesion. MATERIALS: Twenty-seven patients, 17 men and 10 women undergoing femorodistal surgery. Blood was taken preoperatively and from the femoral vein following the release of the cross-clamp. Neutrophils were obtained from five volunteers and incubated with phosphate buffered saline (PBS), preoperative plasma or reperfusion plasma with and without sICAM-1. Neutrophil expression of CD11b and adhesion were measured. MAIN RESULTS: Neutrophil CD11b expression did not change following incubation in the three media. Neutrophil adhesion increased significantly following exposure to reperfusion plasma compared to PBS or preoperative plasma (45.5 adhesion vs. 12.75%, p < 0.01 Mann-Whitney U-test). Soluble ICAM-1 decreased CD11b expression and adhesion in neutrophils exposed to reperfusion plasma only (CD11b expression fell from 15.9 to 3.4 mcf, p < 0.01 Mann-Whitney U-test and adhesion fell to 11.6% cells adhered, p < 0.01). CONCLUSION: An increase in CD11b expression is not required for an increase in neutrophil adhesion. The change in neutrophil adhesion produced by reperfusion plasma can be blocked by sICAM-1. Soluble ICAM-1 may have a physiological role in the regulation of neutrophil adhesion. (+info)
Phenotypic analysis of lymphocytes and monocytes/macrophages in peripheral blood and bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. (2/437)BACKGROUND: The granulomatous inflammation in sarcoidosis is driven by the interplay between T cells and macrophages. To gain a better understanding of this process the expression by these cells of cell surface activation markers, co-stimulatory molecules, and adhesion molecules was analysed. METHODS: CD4+ and CD8+ T lymphocytes from peripheral blood (PBL) or bronchoalveolar lavage (BAL) fluid, as well as paired peripheral blood monocytes and alveolar macrophages from 27 patients with sarcoidosis were analysed by flow cytometry. RESULTS: CD26, CD54, CD69, CD95, and gp240 were all overexpressed in T cells from BAL fluid compared with those from PBL in both the CD4+ and CD8+ subsets, while CD57 was overexpressed only in BAL CD4+ cells. In contrast, CD28 tended to be underexpressed in the BAL T cells. Monocyte/macrophage markers included CD11a, CD11b, CD11c, CD14, CD16, CD54, CD71, CD80 and CD86 and HLA class II. CD11a expression in alveolar macrophages (and peripheral blood monocytes) was increased in patients with active disease and correlated positively with the percentage of BAL lymphocytes. Expression of CD80 in macrophages correlated with the BAL CD4/CD8 ratio. CONCLUSIONS: Our data indicate substantial activation of both CD4+ and CD8+ lung T cells in sarcoidosis. There were also increased numbers of BAL lymphocytes whose phenotypic characteristics have earlier been associated with clonally expanded, replicatively senescent cells of the Th1 type. (+info)
Maturation and apoptosis of primary human acute myeloblastic leukemia cells are determined by TNF-alpha exclusively through CD120A stimulation. (3/437)BACKGROUND AND OBJECTIVE: Tumor necrosis factor-a plays an important role in hematopoiesis. Its effects are mediated through two membrane-bound receptors: TNF-R I (p55; CD 120a) and TNF-R II (p75; CD 120b). The aim of our study was to investigate the relative roles of these receptors. DESIGN AND METHODS: We analyzed in 16 acute myeloid leukemia cases whether TNF-alpha could induce in vitro maturation and apoptosis. We then investigated which of the two receptors was provoking monocytic maturation and which was responsible for apoptosis by using the agonistic MoAb HTR-9, directed at CD120a, and the CD120b antagonistic MoAb UTR-1. RESULTS: Monocytic maturation (morphologic and immunologic) was induced in all cases studied, although to different rates, by TNF-alpha and by HTR-9 incubation. The addition of UTR-1 to TNF-alpha did not abolish maturation, nor did it affect apoptosis, which was present in primary AML cultures after 4 and 10 days. INTERPRETATION AND CONCLUSIONS: We present here evidence that the sole stimulation of CD 120a, but not of CD120b, by TNF-alpha is responsible for bot monocytic maturation and apoptosis of primary AML blasts. (+info)
Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14. (4/437)The activation of phagocytes by lipopolysaccharide (LPS) has been implicated in the pathogenesis of Gram-negative sepsis. Although the interaction between CD14 and LPS is a key event in the signaling cascade, the molecular mechanism by which cellular activation occurs remains obscure. We hypothesized that the main function of CD14 was to bind LPS and transfer it to a second receptor, which then initiates the subsequent signal for cellular activation. Thus, surface binding of LPS to the cell membrane would be the critical step that CD14 carries out. To test this hypothesis, we examined the activity of two other proteins known to bind LPS, lipopolysaccharide-binding protein and bactericidal/permeability-increasing protein. We found that when these normally soluble proteins were expressed in Chinese hamster ovary-K1 fibroblasts as glycosylphosphatidylinositol-anchored proteins, both could substitute for CD14 in initiating LPS signaling. Pharmacological studies with synthetic lipid A analogues demonstrated that these surface expressed LPS-binding proteins had characteristics that were qualitatively identical to membrane CD14. These data support the hypothesis that a receptor distinct from CD14 functions as the actual signal transducer and suggest that surface binding of LPS to the cell membrane is the crucial first step for initiating downstream signaling events. (+info)
ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity. (5/437)Cell adhesion mediated by the CD11/CD18 integrins and their ligands, the ICAMs, is required for many leukocyte functions. In resting cells the integrins are nonadhesive, but when activated they become adhesive for their ligands. Previous findings have shown that a peptide derived from the first Ig domain of ICAM-2 (P1) binds to LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) and activates leukocyte aggregation. Because its mechanism of action has remained poorly understood, we have now studied the peptide-induced ligand binding in detail. Here we show that P1 was able to induce CD11/CD18-dependent adhesion of human T lymphocytes to immobilized, purified ICAM-1, -2, and -3. The optimal peptide concentration was 150 micrograms/ml, whereas concentrations higher than 400 micrograms/ml did not have any stimulatory effect. The increase in adhesion was detectable within 10 min of treatment with the peptide; it was dependent on energy, divalent cations, temperature, and an intact cytoskeleton but was unaffected by protein kinase C and protein tyrosine kinase inhibitors. Peptide treatment resulted in strong stimulation of the binding of soluble, recombinant ICAMs to T lymphocytes, showing that the integrin affinity toward its ligands was increased. Importantly, soluble ICAM-2Fc was also able to induce T lymphocyte adhesion to purified ICAM-1, -2, and -3, and it was a more potent stimulatory molecule than ICAM-1Fc or ICAM-3Fc. (+info)
Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18). (6/437)Even though more immunoglobulin A (IgA) is produced in humans than all other isotypes combined, relatively little is known about receptors that bind the Fc part of IgA. The myeloid IgA receptor, FcalphaRI (CD89), triggers various effector functions in vitro, but its in vivo role remains unclear. Here, a transgenic mouse model is described in which FcalphaRI is expressed under its own regulatory sequences. Receptor expression and regulation by cytokines was comparable to the human situation and hFcalphaRI can trigger phagocytosis and lysis of tumor cells. To analyze the contribution of the FcR gamma chain or the beta2 integrin CR3 (CD11b/CD18) in FcalphaRI biological function, FcalphaRI transgenic mice were crossed with either FcR gamma chain -/- or CR3 -/- mice. In contrast to in vitro data, FcR gamma chain was essential for surface expression of hFcalphaRI in vivo. Functional studies in hFcalphaRI/ gamma-/-mice were, therefore, limited. In vitro studies showed FcR gamma chain to be necessary for phagocytosis. Neither hFcalphaRI expression nor phagocytosis, triggered via hFcalphaRI, were influenced by CR3. Remarkably, the capacity to lyse tumor targets was ablated in hFcalphaRI transgenic/ CR3-/- mice, although binding of neutrophils to tumor cells was intact. This shows a previously unrecognized importance of CR3 for hFcalphaRI-mediated antibody-dependent cellular cytotoxicity (ADCC). (+info)
Decreased superoxide production, degranulation, tumor necrosis factor alpha secretion, and CD11b/CD18 receptor expression by adherent monocytes from preterm infants. (7/437)Preterm infants have an increased incidence of infection, which is principally due to deficiencies in neonatal host defense mechanisms. Monocyte adherence is important in localizing cells at sites of infection and is associated with enhanced antimicrobial functions. We isolated cord blood monocytes from preterm and full-term infants to study their adhesion and immune functions, including superoxide (O2-) generation, degranulation, and cytokine secretion and their adhesion receptors. O2- production and degranulation were significantly diminished, by 28 and 37%, respectively, in adherent monocytes from preterm infants compared to full-term infants (P < 0. 05); however, these differences were not seen in freshly isolated cells. We also observed a significant decrease of 35% in tumor necrosis factor alpha secretion by lipopolysaccharide-stimulated adherent monocytes from preterm infants compared to full-term infants (P < 0.05); however, this difference was not observed in interleukin-1beta or interleukin-6 production by the monocytes. The cell surface expression of the CD11b/CD18 adhesion receptor subunits was significantly decreased (by 60 and 52%, respectively) in monocytes from preterm infants compared to full-term infants (P < 0. 01). The cascade of the immune response to infection involves monocyte upregulation and adherence via CD11b/CD18 receptors followed by cell activation and the release of cytokines and bactericidal products. We speculate that monocyte adherence factors may be important in the modulation of immune responses in preterm infants. (+info)
Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. (8/437)We have previously shown that expression of the human apo A-I transgene on the apo E-deficient background increases HDL cholesterol and greatly diminishes fatty streak lesion formation. To examine the mechanism, prelesional events in atherosclerotic plaque development were examined in 6- to 8-week-old apo E-deficient and apo E-deficient/human apo A-I transgenic mice. A quantitative assessment of subendothelial lipid deposition by freeze-fracture and deep-etch electron microscopy indicated that elevated apo A-I did not affect the distribution or amount of aortic arch subendothelial lipid deposits. Immunohistochemical staining for VCAM-1 demonstrated similar expression on endothelial cells at prelesional aortic branch sites from both apo E-deficient and apo E-deficient/human apo A-I transgenic mice. Transmission electron microscopy revealed monocytes bound to the aortic arch in mice of both genotypes, and immunohistochemical staining demonstrated that the area occupied by bound mononuclear cells was unchanged. Serum paraoxonase and aryl esterase activity did not differ between apo E-deficient and apo E-deficient/human apo A-I transgenic mice. These data suggest that increases in apo A-I and HDL cholesterol inhibit foam cell formation in apo E-deficient/human apo A-I transgenic mice at a stage following lipid deposition, endothelial activation, and monocyte adherence, without increases in HDL-associated paraoxonase. (+info)
List of MeSH codes (D23)
... antigens, cd7 MeSH D23.050.301.264.035.108 --- antigens, cd8 MeSH D23.050.301.264.035.111 --- antigens, cd11 MeSH D23.050. ... antigens, cd7 MeSH D22.214.171.124.108 --- antigens, cd8 MeSH D126.96.36.199.111 --- antigens, cd11 MeSH D188.8.131.52. ... hla-a antigens MeSH D23.050.301.500.450.370.372 --- hla-a1 antigen MeSH D23.050.301.500.450.370.374 --- hla-a2 antigen MeSH ... hla-b antigens MeSH D23.050.301.500.450.380.383 --- hla-b7 antigen MeSH D23.050.301.500.450.380.385 --- hla-b8 antigen MeSH ...
Intercellular adhesion molecule
They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in ...
Lymphocyte function-associated antigen 1
"Shedding of large functionally active CD11/CD18 Integrin complexes from leukocyte membranes during synovial inflammation ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... Lymphocyte function-associated antigen 1 (LFA-1) is found on all T-cells and also on B-cells, macrophages, neutrophils and NK ... It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. LFA-1 is the first to bind T-cells to ...
For example, LFA1 (CD11a/CD18) short representation of Lymphocyte Function-associated Antigen 1, also called αLβ2 integrin Mac1 ... CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 (β2) and mediate ... CD11b/CD18) present on macrophages that is also called Macrophage-1 antigen (CR3) and αmβ2 integrin. CD11c/CD18 also called ...
... antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGB2 Info with links in the Cell Migration ... Schymeinsky J, Mócsai A, Walzog B (August 2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms ... Huang C, Springer TA (August 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) ... It is the beta subunit of four different structures: LFA-1 (paired with CD11a) Macrophage-1 antigen (paired with CD11b) ...
Integrin alpha M
Integrin alphaM at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen Chart Human CD Antigen ... Todd RF, Petty HR (May 1997). "Beta 2 (CD11/CD18) integrins can serve as signaling partners for other leukocyte receptors". The ... Schymeinsky J, Mócsai A, Walzog B (August 2007). "Neutrophil activation via beta2 integrins (CD11/CD18): molecular mechanisms ... also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). ITGAM is also known as CR3A, and cluster of ...
doi:10.1158/2159-8290.CD-11-0209. PMC 3215093 . PMID 22096659. Spitale RC, Tsai MC, Chang HY (May 2011). "RNA templating the ... Correlations were seen between patients with larger tumor size, higher carcinoembryonic antigen (CEA), and increased metastases ...
Katz FE, Parkar M, Stanley K, Murray LJ, Clark EA, Greaves MF (Jan 1985). "Chromosome mapping of cell membrane antigens ... "Shedding of Large Functionally Active CD11/CD18 Integrin Complexes from Leukocyte Membranes during Synovial Inflammation ... Huang C, Springer TA (Aug 1995). "A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) ... Lebedeva T, Dustin ML, Sykulev Y (Jun 2005). "ICAM-1 co-stimulates target cells to facilitate antigen presentation". Current ...
1991). "CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in ... Skubitz KM, Campbell KD, Iida J, Skubitz AP (1996). "CD63 associates with tyrosine kinase activity and CD11/CD18, and transmits ... CD63 antigen is a protein that in humans is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular ... 1992). "Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences". ...
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... te Velde AA, Keizer GD, Figdor CG (1987). "Differential function of LFA-1 family molecules (CD11 and CD18) in adhesion of human ... antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)". Lu C, Takagi J, Springer TA (May 2001). " ... CD11a Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGAL Info with links in the Cell ...
Mouse models of breast cancer metastasis
doi:10.1158/2159-8290.CD-11-0325. PMC 3738298 . PMID 22628410. Shah, S. P.; Morin, R. D.; Khattra, J; Prentice, L; Pugh, T; ... in which MMTV-LTR is used to drive the expression of mammary gland specific polyomavirus middle T-antigen, leading to a rapid ...
Taslima Nasreen, an award-winning writer, physician, secular humanist and human rights activist, is known for her powerful writings on women oppression and unflinching criticism of religion, despite forced exile and multiple fatwas calling for her death. In India, Bangladesh and abroad, Nasreens fiction, nonfiction, poetry and memoir have topped the best-sellers list. Taslima Nasreen was born in Bangladesh. She started writing when she was 13. Her writings won the hearts of people across the border and she landed with the prestigious literary award Ananda from India in 1992. Taslima won The Sakharov Prize for Freedom of Thought from the European Parliament in 1994. She received the Kurt Tucholsky Award from Swedish PEN, the Simone de Beauvoir Award and Human Rights Award from Government of France, Le Prix de l Edit de Nantes from the city of Nantes, France, Academy prize from the Royal Academy of arts, science and literature from Belgium. She is a Humanist Laureate in The International ...
Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support...
(Phys.org) -- Dr. Balaji Sitharaman, PhD, an Assistant Professor in the Department of Biomedical Engineering at Stony Brook University, and a team of researchers developed a new, highly efficacious, potentially safer and ...
La integrina beta-2 o CD18 , dallinglese: cluster of differentiation, è una proteina che nelluomo è codificata dal gene ITGB2. È la subunità beta di quattro diverse strutture: LFA-1 o integrina alphaLbeta2 (in coppia con CD11a) Macrofago-1 antigene o integrina alphaMbeta2 (in coppia con ITGAM o CD11b) Integrina alphaXbeta2 (in coppia con CD11c) Integrina alphaDbeta2 (in coppia con CD11d) Il prodotto proteico del gene ITGB2 è la catena beta dellintegrina beta 2. Le integrine sono parte integrante della superficie proteica delle cellule, sono composte di una catena alfa e una catena beta. Una catena può legarsi con partner multipli determinando conseguentemente azioni diverse da parte della stessa integrina. Ad esempio, la beta 2 si combina con la L-catena alfa per formare lintegrina LFA-1, se si combina, invece, con la M-catena alfa forma la Mac-1 integrina. Le integrine sono note per la loro partecipazione alladesione delle cellule sulle pareti dei vasi sanguigni, nonché per le loro ...
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß2 subunit of LFA1 family (ß2 integrins ...
We have previously reported a newly discovered congenital disorder of neutrophil adhesion, leukocyte adhesion deficiency syndrome type 2 (LAD II). The clinical manifestations of this syndrome are similar to those seen in the classic leukocyte adhesion deficiency syndrome, now designated type 1 (LAD I), but the two syndromes differ in the molecular basis of their adhesion defects. LAD I is caused by a deficiency in the CD18 integrin adhesion molecules while LAD II patients are deficient in expression of sialyl-Lewis X (SLeX), a carbohydrate ligand for selectins. In this report we demonstrate that neutrophils from a LAD II patient bind minimally or not at all to recombinant E-selectin, purified platelet P-selectin, or P-selectin expressed on histamine-activated human umbilical vein endothelial cells, but have normal levels of L-selectin and CD11b/CD18 integrin, and adhere to and migrate across endothelium when CD11b/CD18 is activated. We compare LAD I and LAD II patient neutrophil function in ...
The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.. Developed by Sune Frankild, Albert Pallejà, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.. ...
CD11c is a member of the leukocyte integrin family of adhesion proteins. t is reported to be expressed in normal tissues, mainly on myeloid cells eg.
Sixty paired venous and capillary total neutrophil counts (TNCs) were obtained from 30 healthy, term neonates on days 1 and 2 of life. Day 1 venous TNC (8,200 +/-- 3,800/cu mm) and capillary TNC (10,400 +/- 4,400/cu mm) were significantly different w
Rare leukocyte adhesion deficiency type II (LAD II) is due to an inborn error in fucose metabolism caused by mutations in the guanosine diphosphate-fucose transporter gene. There is a failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s), which is expressed on leukocytes. The patients are unable to fucosylate other glycoproteins, including the H blood group polysaccharide, so they are Bombay phenotype, ie, negative for the O and H blood group antigens and capable of making anti-H antibody. The immunoglobulin M (IgM) and immunoglobulin G (IgG) heavy chains also are not fucosylated, although IgM and IgG are present in normal amounts. ...
Anti-NKG2D/CD314 antibody conjugated to FITC [1D11] validated for Flow Cyt and tested in Human. Referenced in 1 publication. Immunogen corresponding to…
Leukocyte adhesion deficiency (LAD), is a rare autosomal recessive disorder characterized by immunodeficiency resulting in recurrent infections. LAD is currently divided into three subtypes: LAD1, LAD2, and the recently described LAD3, also known as LAD-1/variant. In LAD3, the immune defects are supplemented by a Glanzmann thrombasthenia-like bleeding tendency. LAD was first recognized as a distinct clinical entity in the 1970s. The classic descriptions of LAD included recurrent bacterial infections, defects in neutrophil adhesion, and a delay in umbilical cord sloughing. The adhesion defects result in poor leukocyte chemotaxis, particularly neutrophil, inability to form pus and neutrophilia. Individuals with LAD suffer from bacterial infections beginning in the neonatal period. Infections such as omphalitis, pneumonia, gingivitis, and peritonitis are common and often life-threatening due to the infants inability to properly destroy the invading pathogens. These individuals do not form ...
To assess blood leucocytes gene profiling during recovery phase of septic shock; to test the relation between encoding gene expression and protein level. Gene expression levels were studied at days 0,
Photomicrographs showing changes in CD11/b-IR in the sp | Open-i
Photomicrographs showing changes in CD11/b-IR in the spinal DH (L4-L5) 3 days after formalin injection. Inhibitory effects of ... Antigens, CD11/metabolism. *Cell Shape/drug effects. *Edema/chemically induced/complications/drug therapy/pathology ... Figure 5: Photomicrographs showing changes in CD11/b-IR in the spinal DH (L4-L5) 3 days after formalin injection. Inhibitory ... Figure 5: Photomicrographs showing changes in CD11/b-IR in the spinal DH (L4-L5) 3 days after formalin injection. Inhibitory ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3472237_1744-8069-8-40-5&req=4
Decysin is highly expressed in mature DCs. (A) 28 cycle | Open-i
Antigens, CD11/immunology. *Base Sequence. *Blotting, Northern. *Cloning, Molecular. *DNA, Antisense. *DNA, Complementary/ ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2199019_JEM.970967f4a&req=4
CD11b Antibody (C11b/660) [Alexa Fluor® 647] (NBP2-34573AF647): Novus Biologicals
CD11 antigen-like family member B. *CD11b antigen. *CD11b. *CD11Bintegrin, alpha M (complement component receptor 3, alpha; ... The protocol says to do enzymatic antigen retrieval before incubating with the CD11b antibody, which enzyme is used? *The ... We have 3 CD11b antibodies for IHC-P and just one CD11 b antibody we offer conjugated to FITC, NB110-89474F. ...https://www.novusbio.com/products/cd11b-antibody-c11b-660_nbp2-34573af647
Recombinant Human CD11b protein (ab126010) | Abcam
CD11 antigen like family member B. *CD11 antigen-like family member B ...https://www.abcam.com/recombinant-human-cd11b-protein-ab126010.html
Anti-CD11b antibody [MEM-174] (Phycoerythrin) (ab28101) | Abcam
CD11 antigen like family member B antibody. *CD11 antigen-like family member B antibody ...https://www.abcam.com/cd11b-antibody-mem-174-phycoerythrin-ab28101.html
CD11b Antibody, eFluor® 450 (Monoclonal, M1/70)
Protein Aliases: CD11 antigen-like family member B; CD11B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; cell ... M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood ... were digested to obtain single cells for surface antigen staining and analysis by flow cytometry, as described in Materials and ... were digested to obtain single cells for surface antigen staining and analysis by flow cytometry, as described in Materials and ...https://www.thermofisher.com/antibody/product/CD11b-Antibody-clone-M1-70-Monoclonal/48-0112-82
CD11b Antibody (C11b/660) [DyLight 405LS] (NBP2-34573V3): Novus Biologicals
CD11 antigen-like family member B. *CD11b antigen. *CD11b. *CD11Bintegrin, alpha M (complement component receptor 3, alpha; ... The protocol says to do enzymatic antigen retrieval before incubating with the CD11b antibody, which enzyme is used? *The ... We have 3 CD11b antibodies for IHC-P and just one CD11 b antibody we offer conjugated to FITC, NB110-89474F. ...https://www.novusbio.com/products/cd11b-antibody-c11b-660_nbp2-34573v3
CD11b Antibody (Monoclonal, M1/70.15)
Protein Aliases: antigen CD11b (p170); CD11 antigen-like family member B; CD11b; CD11B (p170); cell surface glycoprotein MAC-1 ... macrophage antigen alpha; macrophage antigen alpha polypeptide; Neutrophil adherence receptor; neutrophil adherence receptor ...https://www.thermofisher.com/antibody/product/CD11b-Antibody-clone-M1-70-15-Monoclonal/MA1-80485
Recombinant Human ITGAX & ITGB2 cell lysate ITGAX & ITGB2-1875HCL - Creative BioMart
CD11 antigen-like family member C; leukocyte adhesion receptor p150,95; myeloid membrane antigen, alpha subunit; leukocyte ... surface antigen p150,95, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; integrin, alpha X (antigen CD11C ( ... leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta ...https://www.creativebiomart.net/description_399646_318.htm
anti-CD11b antibody | Rat CD11b Monoclonal Antibody (Clone M1/70.15)-P05555.2
integrin alpha-M; CD11 antigen-like family member B; CD11B (p170); CR-3 alpha chain; Mac-1 alpha; cell surface glycoprotein MAC ... CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor ... Antigen. Biochemical. cDNA Clone. siRNA. Peptide. Rec./Purified Protein. Custom ELISA Kit. Custom Protein. Custom Antibody. ...https://www.mybiosource.com/prods/Antibody/Monoclonal/CD11b/datasheet.php?products_id=210514
ITGAX antibody | pab70589 | Covalab - Covalab Biotechnology
CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor ... CD11 antigen-like family member C. Leu M5. Leukocyte adhesion glycoprotein p150,95 alpha chain. Leukocyte adhesion receptor ...https://www.covalab.com/cd11c-internal-antibody-3.html
CD11c, APC-eFluor 780, clone: BU15, eBioscience™
AI449405, Cd11c, Cr4, N418, CD11 antigen-like family member C, ITGAX, integrin aX, integrin alpha-X. ... CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a ...https://www.fishersci.ca/shop/products/cd11c-mouse-apc-efluor-780-clone-bu15-ebioscience-2/501129279
Code System Concept
Lymphocyte positive for CD11 antigen (cell). Code System Preferred Concept Name. Lymphocyte positive for CD11 antigen (cell). ...https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=117545001
CD11c, eFluor 450, clone: N418, eBioscience™ 100μg; eFluor 450 CD11c, eFluor 450, clone: N418, eBioscience™
AI449405, Cd11c, Cr4, N418, CD11 antigen-like family member C, ITGAX, integrin aX, integrin alpha-X. ...https://www.fishersci.no/shop/products/cd11c-armenian-hamster-anti-mouse-efluor-450-clone-n418-ebioscience-2/15361690
CD11c Armenian Hamster anti-Mouse, Alexa Fluor® 700, Clone: N418, eBioscience™ 100 μg; Alexa Fluor® 700 CD11c Armenian Hamster...
AI449405, Cd11c, Cr4, N418, CD11 antigen-like family member C, ITGAX, integrin aX, integrin alpha-X. ... CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a ...https://www.fishersci.no/shop/products/cd11c-armenian-hamster-anti-mouse-alexa-fluor-700-clone-n418-ebioscience-1/15372110
Code System Concept
CD11+CD20+ Lymphocyte Current Synonym true false 2839194013 Lymphocyte positive for both CD11 antigen and CD20 antigen Current ... Lymphocyte positive for both CD11 antigen and CD20 antigen (cell). Code System Preferred Concept Name. Lymphocyte positive for ...https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=117546000
Anti-CD11a (Integrin aL)  | Monoclonal Antibodies - Ximbio
CD11 Antigen-Like Family Member A; Antigen CD11A (P180); LFA-1A; CD11A; Antigen CD11A (P180); Lymphocyte Function-Associated ... Antigen/Gene or Protein Targets Integrin alpha L subunit (CD11a, LFA-1 alpha) ... Antigen 1; Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide; Integrin Gene Promoter; Alpha Polypeptide; Integrin ... maintains the structural integrity of the leucocyte function-associated antigen-1 (LFA-1) ligand-binding site in the first ...https://ximbio.com/reagent/151048/anti-cd11a-integrin-al-38
Anti-Integrin aM [ICRF44] | Monoclonal Antibodies - Ximbio
CD11 Antigen-Like Family Member B; Leukocyte Adhesion Receptor MO1; CR-3 Alpha Chain; CD11B; CR3A; Macrophage Antigen Alpha ... Antigen CD11b (P170) 3; CD11b Antigen; MAC-1; MAC1A; SLEB6; MO1A ... Antigen/Gene or Protein Targets Integrin alpha M (CD11b; Mac-1a ... Polypeptide); Neutrophil Adherence Receptor Alpha-M Subunit 3; Macrophage Antigen Alpha Polypeptide 3; Neutrophil Adherence ...https://ximbio.com/reagent/151052/anti-integrin-am-icrf44
产品类别 多克隆抗体 | 博士德生物 BOSTER Biological Technology co.ltd
Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte ... STE20-like serine/threonine-protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine/threonine- ...http://boster.com.cn/product/index/cate/43.html?cate=43&keywords=&page=5
市場調査レポート | がんCD抗原阻害
調査レポート】がんCD抗原阻害剤の世界市場及びパイプライン2015 , 発行日：42217 , 商品コード：KUIK51101 , 発行/調査会社：KuicK Research , Cancer CD Antigens Inhibitors ... CD Antigens Segments in Report:. CD3, CD4, CD9, CD11, CD19, CD20, CD22, CD26, CD27, CD28, CD29, CD33, CD37, CD40, CD44, CD45, ... Cancer CD Antigens Clinical Pipeline Dominated by CD20 Antigen: 44 Drugs. • Cancer CD Antigens Clinical Pipeline is Represented ... Mechanism of CD Antigen Cancer Therapeutics. • Cancerhttps://www.marketreport.jp/kuik51101
CD11 antigen like family member B antibody. *CD11 antigen-like family member B antibody ...http://www.abcam.cn/CD11b-antibody-M170-ab8878.html
Anti-CD11c 抗体 [EP1347Y] (ab52632) | アブカム
CD11 antigen like family member C antibody. *CD11 antigen-like family member C antibody ... Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. For unpurified ... integrin, alpha X (antigen CD11C (p150), alpha polypeptide) antibody. *integrin, alpha X (complement component 3 receptor 4 ... Heat mediated antigen retrieval was performed using ab93684 (Tris/EDTA buffer, pH 9.0). Tissue was counterstained with ...http://www.abcam.co.jp/cd11c-antibody-ep1347y-ab52632.html
Anti-Mouse (Murine) CD11b antibody for Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Synonyms: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell ... Antigen Integrin alpha M (ITGAM) Antibodies show synonyms for this antigen * CD11b/CD18 ... CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor ...https://www.antibodies-online.com/apoptosis-pathway-9/cd11b-antibody-2399/mouse-ihc-p-10973/
Integrins | Catalytic receptors | IUPHAR/BPS Guide to PHARMACOLOGY
CD11 antigen-like family member A , CD11A , Integrin alpha-L , LFA-1 , Ly-15 , Ly-21 , Lymphocyte antigen 15 , integrin, alpha ... CD11 antigen-like family member C , CD11C , integrin alpha X (antigen CD11C (p150), alpha polypeptide) , Leukocyte adhesion ... ADB2 , CD11 antigen-like family member D , CD11d , integrin alpha X , integrin alpha X (Cd11c) , Itgax , Leukointegrin alpha D ... very late antigen-4 , VLA-4 Subunits. integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor). integrin, ...https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=760
Anti-Ratte (Rattus) CD11b Antikörper für Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Synonyms: CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell ... Antigen Integrin alpha M (ITGAM) Antikörper Synonyme für dieses Antigen anzeigen * CD11b/CD18 ... CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor ...https://www.antikoerper-online.de/apoptose-pathway-9/cd11b-antibody-2399/rat-ihc-p-10991/
- Presence of BiTEs, ADC, monoclonal antibodies and tri-functional antibodies for targeting different CD antigens has been commercialized. (marketreport.jp)
- Some of the progress could be observed in case of monoclonal antibodies and same scenario could be observed for other CD antigen cancer therapeutics in coming years. (marketreport.jp)
- CD11 antigens appeared to be strongly expressed only on mature granulocytes, monocytes, and certain lymphocytes, but not significantly on myeloid committed precursor cells. (antibodybeyond.com)
- In this report, we demonstrate that 9.3- lymphocytes express CD11, an antigen which is also present on monocytes and granulocytes. (antibodybeyond.com)