Antigenic Modulation
Antigen-Antibody Reactions
Myasthenia Gravis
A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)
Antigens, Surface
Antigen-Antibody Complex
Antigens, Neoplasm
Dictionaries as Topic
Measles virus
Measles
Subacute Sclerosing Panencephalitis
A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
Measles Vaccine
A live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had measles or been immunized with live measles vaccine and have no serum antibodies against measles. Children are usually immunized with measles-mumps-rubella combination vaccine. (From Dorland, 28th ed)
Antigens, CD46
Mitogens
Dyscalculia
Faculty
Education, Graduate
Faculty, Medical
Faculty, Dental
Faculty, Nursing
Leprosy
Vaccinia virus
Complement Activation
Complement C3
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Complement System Proteins
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Cellular Phone
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Glyceraldehyde-3-Phosphate Dehydrogenases
Mobile Applications
Encyclopedias as Topic
Antigen-Presenting Cells
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Immunological Synapses
The interfaces between T-CELLS and ANTIGEN-PRESENTING CELLS. Supramolecular organization of proteins takes place at these synapses involving various types of immune cells. Immunological synapses can have several functions including LYMPHOCYTE ACTIVATION; enhancing, balancing, or terminating signaling; or directing cytokine secretion.
Histocompatibility Antigens Class II
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Establishment of a human thymic myoid cell line. Phenotypic and functional characteristics. (1/22)
The subset of myoid cells is a normal component of the thymic stroma. To characterize these cells, we immortalized stromal cells from human thymus by using a plasmid vector encoding the SV40 T oncogene. Among the eight cell lines obtained, one had myoid characteristics including desmin and troponin antigens. This new line was designated MITC (myoid immortalized thymic cells). These cells expressed both the fetal and adult forms of muscle acetylcholine receptor (AChR) at the mRNA level, as well as the myogenic transcription factor MyoD1. alpha-Subunit AChR protein expression was detected by flow cytometry and the AChR was functional in patch-clamp studies. In addition, AChR expression was down-modulated by myasthenia gravis sera or by monoclonal antibody anti-AChR on MITC line similarly to TE671 rhabdomyosarcoma cells, making the MITC line an interesting tool for AChR antigenic modulation experiments. Finally, the MITC line expressed LFA-3, produced several cytokines able to act on T cells, and protected total thymocytes from spontaneous apoptosis in vitro. These results are compatible with a role of thymic myoid cells in some steps of thymocyte development. Therefore MITC line appears to be a useful tool to investigate the physiological role of thymic myoid cells. (+info)Nematode infection enhances survival of activated T cells by modulating accessory cell function. (2/22)
The type of immune response generated following exposure to Ag depends on a variety of factors, including the nature of the Ag, the type of adjuvant used, the site of antigenic entry, and the immune status of the host. We have previously shown that infection of rodents with Nippostrongylus brasiliensis (Nb) shifts the development of type 1 allo-specific responses toward type 2 immunity, suggesting nematode modulation of T cell activation. In this report we explore the immunomodulatory effects of Nb on T cell activation. We found that spleen cells from Nb-infected mice exhibited dramatically increased proliferation in response to Con A and anti-CD3. This hyperproliferation could be transferred in vitro to naive splenocytes by coculture with mitomycin C-treated cells from Nb-infected animals. The transfer was mediated by non-T accessory cells and supernatants derived from Con A-activated non-T cells, suggesting the involvement of a soluble factor secreted by accessory cells. The accessory cells secreted high levels of IL-6, and anti-IL-6 treatment abrogated the supernatant-induced hyperproliferation, thus confirming that IL-6 was mediating the effect. Further, spleen cells from Nb-infected mice were more resistant to activation-induced cell death (AICD) following mitogenic stimulation. Reduced AICD was also transferable and IL-6 dependent. Thus, the hyperproliferation was in part due to enhanced activated T cell survival. These phenomena mediated by accessory cells may contribute to the powerful polyclonal activation of type 2 immunity caused by nematode infection. (+info)Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females. (3/22)
OBJECTIVE: Collagen-induced arthritis (CIA) is a model of inflammatory arthritis with many similarities to rheumatoid arthritis (RA). We previously mapped in F(2) offspring of CIA-susceptible DA and CIA-resistant F344 rats, 5 quantitative trait loci (QTLs) for which F344 alleles were associated with reduced CIA severity. In the present study, we sought to characterize the independent arthritis-modulating effects of these 5 QTLs. METHODS: CIA-regulatory regions were transferred from the F344 genome to the DA background or vice versa by repeated backcrossing. The arthritis-modulating effects of the transferred alleles were determined by comparing the severity of experimentally induced arthritis in congenic rats with that in DA rats. RESULTS: Congenic lines with either the F344 major histocompatibility complex (MHC) on the DA background or the DA MHC on the F344 background were resistant to CIA, confirming both MHC and non-MHC contributions to the genetic regulation of CIA. F344 alleles at the Cia3 and Cia5 regions of chromosomes 4 and 10 reduced CIA severity relative to that observed in DA rats. F344 Cia4 and Cia6 regions of chromosomes 7 and 8 failed to significantly alter CIA severity. Arthritis-modifying effects of Cia4 and Cia6 were, however, detected in pristane-induced and/or Freund's incomplete adjuvant oil-induced arthritis. The arthritis-modifying effects of the non-MHC CIA-regulatory loci differed in males and females. CONCLUSION: These congenic lines confirmed the existence and location of genes that regulate the severity of experimental arthritis in rats. Mechanisms responsible for the sex-specificity of individual arthritis-regulatory loci may explain some of the sex differences observed in RA and other autoimmune diseases in humans. (+info)Cell membrane modification for rapid display of proteins as a novel means of immunomodulation: FasL-decorated cells prevent islet graft rejection. (4/22)
Long-term display of exogenous proteins on the cell surface may have important research and therapeutic implications. We report a novel method for the cell-surface display of proteins that involves generation of a chimeric protein with core streptavidin, biotinylation of cells, and "decoration" with the protein. A chimeric protein with the extracellular portions of FasL (SA-FasL) was efficiently displayed on the cell surface within 2 hr without detectable cellular toxicity. Biotin and SA-FasL persisted on the cell surface for weeks in vitro and in vivo. Immunomodulation with SA-FasL-decorated splenocytes effectively blocked alloreactive responses in naive and presensitized rodents and prevented the rejection of allogeneic pancreatic islets. This approach may serve as an alternative to gene transfer-based expression with broad research and therapeutic applications. (+info)T-cell subset analysis of Lewis lung carcinoma tumor rejection: heterogeneity of effectors and evidence for negative regulatory lymphocytes correlating with metastasis. (5/22)
We have analyzed the phenotypes of the T-cell subsets generated in response to Lewis lung carcinoma clones in C57BL/6J recipients. The metastatic derivative, which expresses low levels of H-2Kb gene, predominantly elicited CD8, V beta 8, and V beta 9+ T-cells. The nonmetastatic clone expressing high levels of H-Kb gene triggered a more heterogeneous response of V beta-5, -6, -8, -9, and -11 CD8+ T-cells. Comparison of the T-cell receptor (TCR) expression of the T-cells infiltrating the tumor site with the lymphocytes in the periphery of tumor-bearing animals revealed a pattern of homing of CD4+ T-cells bearing V beta-5, -6, and -11 TCR chains and CD8+ T-cells bearing V beta-5, -6, -9, and -11. Depletion of V beta 5 or V beta 6+ T-cells correlated with accelerated tumor growth, implying their protective role as tumor-specific effectors and consistent with the cytotoxicity of T-cells with this TCR phenotype. V beta 11 TCR expression in the tumor-infiltrating lymphocytes increased with the tumor size. Depletion of V beta 11+ T-cells enhanced resistance to primary tumor growth and conferred protection from metastasis in recipients cleared of V beta 5 and V beta 6 T-cell subsets. Those results suggest that tumor-specific effectors as well as negative regulator T-cells home, infiltrate, and coexist in the tumor site. (+info)Expression of major histocompatibility complex class II and costimulatory molecules in oral carcinomas in vitro. (6/22)
Recognition in the 1980 s that keratinocytes can express class II molecules of the Major Histocompatibility Complex (MHC) first raised the possibility that these cells might have an immunological function, and may even act as antigen presenting cells (APC). For effective T lymphocyte activation, APC require, in addition to MHC II, appropriate costimulatory signals. The aim of this study was to determine the expression of MHC class II and the co-stimulatory molecules CD40, CD80 and CD86 in keratinocytes derived from healthy oral mucosa and oral carcinomas. Using flow cytometry, it was confirmed that oral keratinocytes, switch on, expression of MHC class II molecules after stimulation with IFNgamma in vitro. All keratinocyte lines expressed CD40 constitutively; by contrast, CD80 and CD86 were universally absent. Loss of CD80 and CD86 may be one means whereby tumours escape immunological surveillance. (+info)Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to man. (7/22)
The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I-restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure. (+info)Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39(263-275) epitope: an MHC anchor variant peptide for immune modulation. (8/22)
We sought to identify an altered peptide ligand (APL) based on the endogenously expressed synovial auto-epitope of human cartilage glycoprotein-39 (HC gp-39) for modulation of cognate, HLA-DR4-restricted T cells. For this purpose we employed a panel of well-characterized T cell hybridomas generated from HC gp-39-immunized HLA-DR4 transgenic mice. The hybridomas all respond to the HC gp-39(263-275) epitope when bound to HLA-DR4(B1*0401) but differ in their fine specificities. First, the major histocompatibility complex (MHC) and T-cell receptor (TCR) contact residues were identified by analysis of single site substituted analogue peptides for HLA-DR4 binding and cognate T cell recognition using both T hybridomas and polyclonal T cells from peptide-immunized HLA-DR4 transgenic mice. Analysis of single site substituted APL by cognate T cells led to identification of Phe265 as the dominant MHC anchor. The amino acids Ala268, Ser269, Glu271 and Thr272 constituted the major TCR contact residues, as substitution at these positions did not affect HLA-DR4(B1*0401) binding but abrogated T cell responses. A structural model for visualisation of TCR recognition was derived. Second, a set of non-classical APLs, modified at the MHC key anchor position but with unaltered TCR contacts, was developed. When these APLs were analysed, a partial TCR agonist was identified and found to modulate the HC gp-39(263-275)-specific, pro-inflammatory response in HLA-DR4 transgenic mice. We identified a non-classical APL by modification of the p1 MHC anchor in a synovial auto-epitope. This APL may qualify for rheumatoid arthritis immunotherapy. (+info)
The effect of antigenic modulation on mitogenic stimulation of lymphoc by P Draber and V Viklicky
Antigenic modulation of Murine T lymphocyte surface markers with Anti-CD2 monoclonal antibody in vitro :: MEDICA, MUSC...
Cd81 - CD81 antigen - Mus musculus (Mouse) - Cd81 gene & protein
High Nitrate Level .... please advise - Aquarium Advice - Aquarium Forum Community
Antigenic modulation | definition of antigenic modulation by Medical dictionary
CD44 variant isoforms are preferentially expressed in basal epithelial of non-malignant human fetal and adult tissues - edoc
Antibody evasion by the N terminus of murid herpesvirus-4 glycoprotein B - UQ eSpace
Immunodeficiency 7, Tcr-Alpha/beta Deficient disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
MEDICA
Virion endocytosis is a major target for Murid Herpesvirus-4 neutralization. - Glauser D
Immunologic injury in measles virus infection. II. Suppression of immune injury through antigenic modulation. | Journal of...
Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4 | Microbiology Society
Antibody limits in vivo murid herpesvirus-4 replication by IgG Fc receptor-dependent functions - UQ eSpace
An Essential Role for CD44 Variant Isoforms in Epidermal Langerhans Cell and Blood Dendritic Cell Function | JCB
CD44 isoforms in prognosis of breast cancer - edoc
Search Results for CD44 | Genetex Inc.
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Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma. | Sigma-Aldrich
Identification of residues necessary for clonally specific recognition of a cytotoxic T cell determinant | Meta
T Cell Recognizing [image] | EurekAlert! Science News
Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T...
A 32-kD GTP-binding protein associated with the CD4-p56lck and CD8-p56lck T cell receptor complexes | Science
Repository of UOI Olympias: CD44 family and gynaecological cancer
Biomedicines | Free Full-Text | HGF Modulates Actin Cytoskeleton Remodeling and Contraction in Testicular Myoid Cells
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Thomas P. Stossel
Antigenic modulation and turnover in human neutrophils. J Clin Invest. 1979; 64:321-325. 45. Hartwig JH, Stossel TP. ... Modulation of gelsolin function by phosphatidylinositol-4, 5- bisphosphate. Nature. 1987; 325:362-364. 98. Ito T, Zaner KS, ...
Trogocytosis
This effect leads to tumors cell escape by antigenic modulation. Reducing the dose of therapeutic antibodies to limit the ... Major findings along these lines are: cytotoxic T lymphocytes having captured antigenic peptide-MHC complexes can be killed by ... through trogocytosis contribute to affinity maturation of T cell response by selecting high-affinity T cell down-modulation of ... are involved in a negative regulatory feed-back loop leading to their inactivation dendritic cells stripped of antigenic ...
Gene Shearer
Modulation of inflammation and immunity by cyclic AMP. Science 184: 19 28, 1974. Shearer GM. Cell mediated cytotoxicity to ... Antigenic peptides recognized by T helper lymphocytes from asymptomatic, HIV seropositive individuals. Nature 339: 383 385, ... Type 1/Type 2 cytokine modulation of T cell programmed cell death as a model for HIV pathogenesis. Proc Natl Acad Sci USA 91: ...
Elwira Lisowska
... an example of modulation of antigenic properties of peptide by its glycosylation". Blood. 84 (7): 2340-2345. doi:10.1182/blood. ... Lisowska, Elwira (2002-10-11). "The role of glycosylation in protein antigenic properties". Cellular and Molecular Life ... Lisowska, Elwira (2001), Wu, Albert M. (ed.), "Antigenic Properties of Human Glycophorins - An Update", The Molecular ... These studies were important in characterization of antigenic properties of human glycophorins. She became head of Laboratory ...
Jung-Min Lee
Lee's clinical trial is the first to test the modulation of immune-checkpoint activity by increasing the antigenic ...
Hepatitis C virus
NS5A is a hydrophilic phosphoprotein which plays an important role in viral replication, modulation of cell signaling pathways ... It appears to be antigenic but its function is unknown. Replication[edit]. ...
Tripanosomátidos, a enciclopedia libre
"The cell division cycle of Trypanosoma brucei brucei: timing of event markers and cytoskeletal modulations". Philos. Trans. R ... "Antigenic variation in the African trypanosome: molecular mechanisms and phenotypic complexity". Cell. Microbiol. 11 (12): ...
Trypanosomatida
Morrison LJ, Marcello L, McCulloch R; Marcello; McCulloch (December 2009). "Antigenic variation in the African trypanosome: ... timing of event markers and cytoskeletal modulations". Philosophical Transactions of the Royal Society B. 323 (1218): 573-88. ...
Sistem imun bahasa Indonesia, ensiklopedia bebas
Welling GW, Wiejer WJ, van der Zee R, Welling-Werster S. (1985). "Prediction of sequential antigenic regions in proteins". J ... Spelman, K (2006). "Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators". ... "Immune Modulation of Stem Cells and Regeneration". Cell Stem Cell (dalam bahasa English). 15 (1): 14-25. doi:10.1016/j.stem. ... "Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from ...
T cell receptor revision
"Modulation of TCRβ surface expression during TCR revision". Cellular Immunology. 272 (2): 124-129. doi:10.1016/j.cellimm. ... is a process in the peripheral immune system which is used by mature T cells to alter their original antigenic specificity ... which are able to recognize almost any antigenic structure/sequence. The paradigm of adaptive immunity is that a single T cell ...
CCR8 (gene)
More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge ... "HIV-1 infection and chemokine receptor modulation". Curr. HIV Res. 2 (1): 39-50. doi:10.2174/1570162043484997. PMID 15053339. ...
Antibiotic
Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ... and there is the additional concern of uncertain immune responses to these large antigenic cocktails. There are considerable ...
Autoimmunity
Idiotype Cross-Reaction - Idiotypes are antigenic epitopes found in the antigen-binding portion (Fab) of the immunoglobulin ... The details of parasite immune modulation are not yet known, but may include secretion of anti-inflammatory agents or ... against a backdrop of genetic predisposition and environmental modulation. It is beyond the scope of this article to discuss ...
Apolipoprotein D
Do Carmo, S; Forest, JC; Giguère, Y; Masse, A; Lafond, J; Rassart, E (2 September 2009). "Modulation of Apolipoprotein D levels ... "Protein polymorphism of a human plasma apolipoprotein D antigenic epitope". Journal of Lipid Research. 30 (6): 865-75. PMID ... Do Carmo, S; Séguin, D; Milne, R; Rassart, E (15 February 2002). "Modulation of apolipoprotein D and apolipoprotein E mRNA ... Terrisse, L; Séguin, D; Bertrand, P; Poirier, J; Milne, R; Rassart, E (18 June 1999). "Modulation of apolipoprotein D and ...
Astrocyte
Lineage and antigenic phenotype[edit]. These have been established by classic work by Raff et al. in early 1980s on Rat optic ... Modulation of synaptic transmission: In the supraoptic nucleus of the hypothalamus, rapid changes in astrocyte morphology have ... Santello M, Volterra A (2008). "Synaptic modulation by astrocytes via Ca2+-dependent glutamate release". Neuroscience. Mar. 158 ... "Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD". Cell. 148 (5): 1039-50 ...
Lentivirus
Antigenic properties[edit]. Serological Relationships: Antigen determinants are type-specific and group-specific. Antigen ... a paradigm for the modulation of cell surface receptors". Immunological Reviews. 168: 51-63. doi:10.1111/j.1600-065x.1999. ... Glycosylation seems to play a structural role in the concealment and variation of antigenic sites necessary for the host to ... Classification of members of this taxon is infrequently based on their antigenic properties. ...
T-cell receptor
When the TCR engages with antigenic peptide and MHC (peptide/MHC), the T lymphocyte is activated through signal transduction, ... The TCR affinity for peptided/MHC has a direct impact on modulation of T-cell function. T cells are very sensitive to their ... although CDR1 of the alpha chain has also been shown to interact with the N-terminal part of the antigenic peptide, whereas ... which accounts for the even greater diversity of T-cell receptor specificity for processed antigenic peptides. ...
GYPB
The antigenic determinant for the blood group Ss is located at residue 29 where S has a methionine and s a threonine. This is ... multiple gene rearrangements and modulation of splice site usage result in extensive diversification". Hum. Mutat. 6 (3): 199- ... Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification". J. Biol. ... Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification". J. Biol. ...
Virus
Modulation of host cell stress responses by human cytomegalovirus. Current Topics in Microbiology and Immunology. 2008;325:263- ... Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses. Proceedings of the National ... These include a process called antigenic drift where individual bases in the DNA or RNA mutate to other bases. Most of these ... How antigenic shift, or reassortment, can result in novel and highly pathogenic strains of human flu ...
Cell (biology)
Fimbriae are formed of a protein called pilin (antigenic) and are responsible for the attachment of bacteria to specific ... Cells are capable of synthesizing new proteins, which are essential for the modulation and maintenance of cellular activities. ...
Maltose-binding protein
Park S, Liu G, Topping TB, Cover WH, Randall LL (February 1988). "Modulation of folding pathways of exported proteins by the ... The permissive sites that were internal to MBP, were used to insert antigenic peptides and challenge the immune response in ...
Alae (nematode anatomy)
De Giorgi, C.; De Luca, F.; Di Vito, M.; Lamberti, F. (20 February 1997). "Modulation of expression at the level of splicing of ... "Ultrastructural immuno-localization of CUT-1 and CUT-2 antigenic sites in the cuticles of the nematode Caenorhabditis elegans ...
Polysaccharide
This "capsule" cloaks antigenic proteins on the bacterial surface that would otherwise provoke an immune response and thereby ... June 2020). "Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion". PLOS Biology. 18 (6): ... June 2020). "Modulation of bacterial multicellularity via spatio-specific polysaccharide secretion". PLOS Biology. 18 (6): ...
Virus
Antigenic shift occurs when there is a major change in the genome of the virus. This can be a result of recombination or ... Alwine JC (2008). "Modulation of host cell stress responses by human cytomegalovirus". Current Topics in Microbiology and ... These include a process called antigenic drift where individual bases in the DNA or RNA mutate to other bases. Most of these ... December 2011). "Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses". Proceedings ...
Glycophorin A
Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification". J. Biol. ... multiple gene rearrangements and modulation of splice site usage result in extensive diversification". Hum. Mutat. 6 (3): 199- ... Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification". J. Biol. ... are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood ...
G-quadruplex
Moreover, oxidative DNA damage like 8-oxo-dG contributes to carcinogenesis through the modulation of gene expression, or the ... quadruplexes have also been reported in allowing programmed recombination of immunologlobin heavy genes and the pilin antigenic ... or the modulation of gene expression. Upon insertion of 8-oxo-dG into thymidine kinase gene of humans, it was determine that if ... "Characterization of the G-quadruplexes in the duplex nuclease hypersensitive element of the PDGF-A promoter and modulation of ...
Heparanase
"Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in ... "Overexpression of heparanase multiple antigenic peptide 2 is associated with poor prognosis in gastric cancer: Potential for ...
Antibody-dependent enhancement
2018). "Modulation of Dengue/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against ... The viruses that can cause ADE frequently share some common features such as antigenic diversity, abilities to replicate and ... Janoff, E. N.; Wahl, S. M.; Thomas, K.; Smith, P. D. (September 1995). "Modulation of human immunodeficiency virus type 1 ... Original antigenic sin Other ways in which antibodies can (unusually) make an infection worse instead of better Blocking ...
Hepadnaviridae
Its function and significance are poorly understood but it is suspected to be associated with host gene expression modulation. ...
Natural killer cell
Watzl C (2014). How to trigger a killer: modulation of natural killer cell reactivity on many levels. Advances in Immunology. ... even in the absence of surface adhesion molecules and antigenic peptides. This role of NK cells is critical to immune success ... Lodoen MB, Lanier LL (2005). "Viral modulation of NK cell immunity". Nature Reviews Microbiology. 3 (1): 59-69. doi:10.1038/ ...
MYH9
Accurate definition of the antigenic site around the disulphide bridge 30-115 (site 3) by 'surface-simulation' synthesis". The ... "Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2". Scientific Reports. 6: 20554. doi:10.1038/ ...
Cell (biology)
Fimbriae are formed of a protein called pilin (antigenic) and are responsible for the attachment of bacteria to specific ... Cells are capable of synthesizing new proteins, which are essential for the modulation and maintenance of cellular activities. ...
T cell
Optimal CD8+ T cell response relies on CD4+ signalling.[33] CD4+ cells are useful in the initial antigenic activation of naïve ... "Modulation of autoimmune diseases by interleukin (IL)-17 producing regulatory T helper (Th17) cells". Indian J. Med. Res. 138 ... The antigenic molecules that activate γδ T cells are still mostly unknown. However, γδ T cells are not MHC-restricted and seem ...
Cannabinoid receptor type 1
positive regulation of acute inflammatory response to antigenic stimulus. • learning or memory. • nociception. • negative ... However, as with the rest of the brain, it plays a crucial role in modulation of NT release. ... IN the visual system, cannabinoids agonist induce a dose dependent modulation of calcium, chloride and potassium channels. This ... "Allosteric modulation of the cannabinoid CB1 receptor". Molecular Pharmacology. 68 (5): 1484-95. doi:10.1124/mol.105.016162. ...
Astrocyte
Lineage and antigenic phenotypeEdit. These have been established by classic work by Raff et al. in early 1980s on Rat optic ... Modulation of synaptic transmission: In the supraoptic nucleus of the hypothalamus, rapid changes in astrocyte morphology have ... Santello M, Volterra A (2008). "Synaptic modulation by astrocytes via Ca2+-dependent glutamate release". Neuroscience. Mar. 158 ... "Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD". Cell. 148 (5): 1039-50 ...
Heat shock protein
In the simplified view of this pathway HSPs are usually not mentioned: antigenic peptides are generated in proteasome, ... "HSP90 and Immune Modulation in Cancer", Advances in Cancer Research, Elsevier, pp. 191-224, doi:10.1016/bs.acr.2015.10.001 ...
Cannabinoid receptor type 1
positive regulation of acute inflammatory response to antigenic stimulus. • learning or memory. • nociception. • negative ... "Allosteric modulation of the cannabinoid CB1 receptor". Molecular Pharmacology. 68 (5): 1484-95. doi:10.1124/mol.105.016162. ... "Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor". ACS Chemical Neuroscience. 8 (6): 1188-1203. doi:10.1021/ ... cannabinoids agonist induce a dose dependent modulation of calcium, chloride and potassium channels. This alters vertical ...
MHC class I
These results suggest PirB may be involved in modulation of synaptic plasticity in the visual cortex. ... "Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the ...
Immunologic adjuvant
Glenny A, Pope C, Waddington H, Wallace U (1926). "The antigenic value of toxoid precipitated by potassium alum". J Pathol ... "The adjuvant component α-tocopherol triggers via modulation of Nrf2 the expression and turnover of hypocretin in vitro and its ... Because immune systems have evolved to recognize these specific antigenic moieties, the presence of an adjuvant in conjunction ...
Murine respirovirus
However, the antigenic cross-reactivity among these two representatives within the genus Respirovirus may explain why SeV ... August 2011). "Modulation of human beta-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial ... The virus genome has high similarity with human parainfluenza virus 1 (HPIV-1) and the two viruses share common antigenic ... Ryan LK, Diamond G (June 2017). "Modulation of Human β-Defensin-1 Production by Viruses". Viruses. 9 (6): 153. doi:10.3390/ ...
Blastocystosis
Immune modulation: Blastocystis has been shown to provoke cells from the human colon to produce inflammatory cytokines ... Lanuza MD, Carbajal JA, Villar J, Mir A, Borras R (1999). "Soluble-protein and antigenic heterogeneity in axenic Blastocystis ...
CD4+ T cells and antitumor immunity
MHC class II molecules in tumor immunology: prognostic marker and target for immune modulation. Immunobiology 211:6-8, pp. 616- ... MHC class II and endogenously synthesized antigenic proteins are all present. These antigen proteins are prevented from binding ... Genetic modulation of tumor antigen presentation. Methods in Biotechnology 18:4, pp. 167-172. ...
Biochemical cascade
Therefore, the antigenic receptors play a central role in signal transduction in lymphocytes, because when antigens interact ... triggering and modulation of phosphorylation events". Free Radical Biology & Medicine. 41 (4): 528-40. doi:10.1016/j. ...
West Nile fever
Wanasen N, Nussenzveig RH, Champagne DE, Soong L, Higgs S (2004). "Differential modulation of murine host immune response by ... WNV is one of the Japanese encephalitis antigenic serocomplex of viruses. Image reconstructions and cryoelectron microscopy ...
Osteopontin
Chien YC, Masica DL, Gray JJ, Nguyen S, Vali H, McKee MD (August 2009). "Modulation of calcium oxalate dihydrate growth by ... In contrast, neutralization of Opn-s during antigenic challenge exacerbates allergic airway disease. These effects of Opn-s are ... during primary sensitization and Th2-promoting conventional DCs during secondary antigenic challenge. OPN deficiency was also ...
Antigenic modulation | definition of antigenic modulation by Medical dictionary
What is antigenic modulation? Meaning of antigenic modulation medical term. What does antigenic modulation mean? ... Looking for online definition of antigenic modulation in the Medical Dictionary? antigenic modulation explanation free. ... modulation. (redirected from antigenic modulation). Also found in: Dictionary, Thesaurus, Encyclopedia. modulation. [mod″u-la´ ... antigenic modulation. the alteration of antigenic determinants in a living cell surface membrane following interaction with an ...
Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I...
Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I ... Two explanations for this have been proposed: antigenic modulation whereby mAb:CD20 complexes are internalized in a B cell ... Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I ... Shaving Is an Epiphenomenon of Type I and II Anti-CD20-Mediated Phagocytosis, whereas Antigenic Modulation Limits Type I ...
Modulation of Antigenic Phenotype in Cultured Human Osteoblast-like Cells by FGFb, TGFβ1, PDGF-BB, IL-2, IL-1β, LPS and IFNγ |...
Modulation of Antigenic Phenotype in Cultured Human Osteoblast-like Cells by FGFb, TGFβ1, PDGF-BB, IL-2, IL-1β, LPS and IFNγ E ... Modulation of Antigenic Phenotype by IL-1β, IFNγ and TGFβ1 on Cultured Human Decidual Stromal Cells Biosci Rep (February, 2004) ... E. Pérez, O. García-Martínez, M. Arroyo-Morales, C. Reyes-Botella, C. Ruiz; Modulation of Antigenic Phenotype in Cultured Human ... Antigenic Profile of Osteoblasts Present in Human Bone Tissue Sections Biosci Rep (June, 2006) ...
Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL...
Antigenic modulation of MLr as tested by trypan-blue exclusion and by chromium51 release does not lead to a measurable change ... Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL ... Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL ... The procedure of antigenic modulation showed that the MLr antigen resides on MTVgp52, the major protein of the envelope. There ...
Immunologic injury in measles virus infection. II. Suppression of immune injury through antigenic modulation. | Journal of...
Suppression of immune injury through antigenic modulation. B S Joseph B S Joseph ... Modulation of surface viral antigens can occur in the absence of cap formation and is fully reversible once measles virus ... Suppression of immune injury through antigenic modulation.. J Exp Med 1 October 1975; 142 (4): 864-876. doi: https://doi.org/ ...
Antigenic modulation of junctional acetylcholine receptor is n...
Antigenic modulation of junctional acetylcholine receptor is not sufficient to account for the development of myasthenia gravis ... Antigenic modulation of junctional acetylcholine receptor is not sufficient to account for the development of myasthenia gravis ... to test the possibility that antigenic modulation of AChR may be the principle mechanism whereby this reduction in AChR density ... the role of antigenic modulation as a major pathologic mechanism in MG is questioned. ...
The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective...
"The effect of antigenic modulation on mitogenic stimulation of lymphoc" by P Draber and V Viklicky
Antigenic modulation of Murine T lymphocyte surface markers with Anti-CD2 monoclonal antibody in vitro :: MEDICA, MUSC...
Antigenic Modulation. Immunosuppression. Mice. Antigenic Modulation. Antibodies, Monoclonal, Humanized. Antibodies, Monoclonal ... Antigenic modulation of Murine T lymphocyte surface markers with Anti-CD2 monoclonal antibody in vitro ... Post a Comment for Antigenic modulation of Murine T lymphocyte surface markers with Anti-CD2 monoclonal antibody in vitro ... Antigenic modulation of Murine T lymphocyte surface markers with Anti-CD2 monoclonal antibody in vitro. ...
Immunochemical characterization of 2 antigenic sites on human apolipoprotein-A-I : localization and lipid modulation of these...
Antigenic modulation induced by monoclonal-antibodies - antibodies to measles-virus hemagglutinin alters expression of other...
Detection of anti-adalimumab antibodies in a RA responsive cohort of patients using three different techniques.
Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum.
Antigenic Modulation. Loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one ... Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies. ... Reward-based memory modulation is thought to result from encoding and.... Interactions of the tricyclic antidepressant drug ... Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum.. 08:00 EDT 22nd October 2015 , ...
Immune Mechanisms in Renal Disease, Book by Nancy Cummings (Paperback) | chapters.indigo.ca
Efferent Limb.- 6. Modulation of Mesangial Afferent and Efferent Limb.- 7. Conclusion.- References.- 9 The Influence of ... Morphologic and Antigenic Relationships.- 3. Morphologic Tracer Studies.- 4. Kinetic Studies of Mesangial Function.- 5. ... 40 Modulation of Autoimmunity by Sex Hormones.- 1. Sexual Influence in Autoimmune Disease.- 2. Summary.- References.- 41 Thymic ...
Denise M. Monack | Stanford Medicine Profiles
... a phenomenon known as antigenic or phenotypic modulation. B. pertussis also varies between metastable genetic states, or phases ... Modulation of virulence by two acidified nitrite-responsive loci of Salmonella enterica serovar Typhimurium INFECTION AND ... Survival in macrophages and modulation of immune cells migration allow Salmonella to evade various immune responses. The ...
Community Academic Profiles - Faculty & Researchers - Stanford Medicine
... a phenomenon known as antigenic or phenotypic modulation. B. pertussis also varies between metastable genetic states, or phases ... Modulation of virulence by two acidified nitrite-responsive loci of Salmonella enterica serovar Typhimurium INFECTION AND ... Survival in macrophages and modulation of immune cells migration allow Salmonella to evade various immune responses. The ...
Thomas P. Stossel - Wikipedia
Characterization of a TL−variant of a homozygous TL+ mouse lymphoma | SpringerLink
The Shaving Reaction: Rituximab/CD20 Complexes Are Removed from Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Cells by...
... an effect called antigenic modulation (2, 3, 19, 20). The result of this antigenic modulation is that the cancer cell escapes ... Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody. Eur. J. Immunol. 12: 979-982. ... Antigenic modulation described in previous reports may have been mediated by such shaving, and our findings may have profound ... Antibody-induced antigenic modulation is antigen dependent: characterization of 22 proteins on a malignant human B cell line. J ...
Complement, Viruses, and Virus-Infected Cells | SpringerLink
Antigenic modulation and abrogation of lymphocyte lysis of virus-infected cells. Clin Immunol Immunopathol 9: 55PubMedCrossRef ... Molecular events in antibody induced antigenic modulation. J Immunol 125: 78PubMedGoogle Scholar ... Boyse EA, Old LJ, Luell S (1963) Antigenic properties of experimental leukemias. II. Immunological studies in vivo with C57 BL/ ... As replicating agents, they have the ability to serve as a persistent or increasing antigenic challenge. Through several ...
JCI -
The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses
... antigenic mimicry, which can result in either immune modulation (e.g., MHC I analogs) or sequestration of the pathogen from the ... Human antibody responses to VlsE antigenic variation protein of Borrelia burgdorferi. J Clin Microbiol 1999. 37:3997-4004. View ... Kyes, S, Horrocks, P, Newbold, C. Antigenic variation at the infected red cell surface in malaria. Annu Rev Microbiol 2001. 55: ... Apoptotic modulation by MIMs is just one mechanism of immune evasion used by human pathogens. Elucidation of the structure of ...
Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy | Blood Journal
GAPDH: Biological Properties and Diversity (ebook) by Norbert W. Seidler | 9789400747166
Borrelia burgdorferi Alters Its Gene Expression and Antigenic Profile in Response to CO2 Levels | Journal of Bacteriology
Modulation of the protein produced under the experimental conditions used is independent of the pH. A B. burgdorferi B31 ... Borrelia burgdorferi Alters Its Gene Expression and Antigenic Profile in Response to CO2 Levels. Jenny A. Hyde, Jerome P. ... Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks. Proc. Natl. Acad. Sci. USA 98:670 ... 1). Major antigenic differences for B. burgdorferi AH130 and MSK5 were observed throughout the immunoblot, and there was ...
Trogocytosis - Wikipedia
This effect leads to tumors cell escape by antigenic modulation. Reducing the dose of therapeutic antibodies to limit the ... Major findings along these lines are: cytotoxic T lymphocytes having captured antigenic peptide-MHC complexes can be killed by ... through trogocytosis contribute to affinity maturation of T cell response by selecting high-affinity T cell down-modulation of ... are involved in a negative regulatory feed-back loop leading to their inactivation dendritic cells stripped of antigenic ...
US7176296B2 - Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides
...
Antigenic composition US7956043B2 (en) 2011-06-07. 5′ CpG nucleic acids and methods of use ... Antisense oligonucleotide modulation of multidrug resistance-associated protein US5663153A (en) * 1994-03-25. 1997-09-02. Isis ... Antisense oligonucleotide modulation of multidrug resistance-associated protein WO1998049288A1 (en) 1997-04-30. 1998-11-05. ... Modulation of oligonucleotide CpG-mediated immune stimulation by positional modification of nucleosides Download PDF Info. ...
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Mathematical Immune Response Models
In a mathematical model of the cellular antitumor immune response, we studied the possible role of antigenic modulation as a ... Mathematical modeling for antibody therapy in the setting of antigenic modulation.. Dillman RO, Koziol JA, Shawler DL San Diego ... Mathematical modeling for antibody therapy in the setting of antigenic modulation.. * Mathematical modeling of antigen and ... Conversely, the parameter analysis suggests that antigenic modulation plays a deleterious role in cytotoxic antibody responses ...
Antigenic Variation in Vector-Borne Pathogens - Volume 6, Number 5-October 2000 - Emerging Infectious Diseases journal - CDC
These pathogens use antigenic variation to prolong their circulation in the blood and thus increase the likelihood of ... Antigenic variation poses a challenge in the development of vaccines against vector-borne pathogens. ... bacterial and protozoal vector-borne pathogens have acquired similar genetic mechanisms for successful antigenic variation. ... These include tissue tropism, shielding of adjacent molecules, inhibition of phagocytosis, modulation of antigen presentation, ...
EpitopesAcetylcholine receptorAntigensProteinsAddition to being antCalled antigenic variationDeterminantsMeasles virus infectionAntibodyMitogenic stimulationMonoclonal-antibodiesLymphocyteAChRCharacterizationGene expressionStimulationAntigenVariationCell differentiationVariantsImmunoregulatorySurfaceMAbsMechanismsExperimentalDifferentiationCellsCovalentGlycoproteinInfectionCytokinesPeptideRituximabMechanismVirusesInductionImmunityPersistentShiftSerumMoleculesMarkersTuberculosisAutoantibodiesMiceLymphocytesGenesIneffectiveResponseRegulationFunctional
Epitopes7
- Clinical investigations have revealed that infusion of immunotherapeutic mAbs directed to normal or tumor cells can lead to loss of targeted epitopes, a phenomenon called antigenic modulation. (jimmunol.org)
- Modulation of recombinant antigenic constructs containing multi-epitopes towards effective reduction of atherosclerotic lesion in B6;129S-Ldlr(tm1Her)Apob(tm2Sgy)/J mice. (jove.com)
- Antigenic epitopes were incorporated into a dendroaspin scaffold. (jove.com)
- In the present study, therefore, the protective effect of various combinations of anti-gpE MAbs representing antigenic epitopes other than Hs was studied on mice infections with JEV group II strains: JEV strains 641686 and 691004. (pagepress.org)
- The protective effect of several combinations of anti-gpE MAbs representing different antigenic epitopes might be due to the enhancement of binding within the same group and also between different MAb groups. (pagepress.org)
- 16. The antigenic product of claim 1, wherein the antigenic peptide comprises two epitopes of said deposit-forming polypeptide. (freepatentsonline.com)
- T-cell lymphocytes are believed to react against thyroid follicular cells with shared antigenic epitopes in the retroorbital space. (medscape.com)
Acetylcholine receptor3
- Antigenic modulation of junctional acetylcholine receptor is n. (mysciencework.com)
- Antigenic modulation of junctional acetylcholine receptor is not sufficient to account for the development of myasthenia gravis in receptor immunized mice. (mysciencework.com)
- A rapid, fluorescence-based assay for detecting antigenic modulation of the acetylcholine receptor on human cell lines. (semanticscholar.org)
Antigens9
- Antigenic modulation of mammary tumour virus envelope antigen or GR thymic lymphoma cells in relation to expressions of H-2, TL cell-surface antigens and THY1. (stanford.edu)
- Antigenic modulation of MLr as tested by trypan-blue exclusion and by chromium51 release does not lead to a measurable change in the expression of H-2K, H-2D, TL and Thy1.2 antigens. (stanford.edu)
- The latter analysis showed that the number of antigenic sites per cell are about the same for MLr and the two H-2 antigens, while TL antigens are scarcer and Thy1.2 antigens are more abundant. (stanford.edu)
- Modulation of surface viral antigens can occur in the absence of cap formation and is fully reversible once measles virus antibodies are removed from culture medium. (rupress.org)
- Others integrate into the genome and may be passed from generation to generation, thus blurring the distinctions between foreign antigenic structures and host antigens on the surface of viruses or virus-infected cells. (springer.com)
- True antigenic variation, however, arises in a single clone or genotype in a single host and "involves the loss, gain, or change in a particular antigenic group, usually by loss, gain, or change in one of the polypeptide or polysaccharide antigens…" (3) . (cdc.gov)
- By antibody-induced antigenic modulation, we mean the removal of antigens from the surface of cells by specific antibody. (springer.com)
- Antibody modulation is not exclusive of virus, in vitro treatment of rabbit endothelial cells with specific anti-endothelial antibodies resulted in redistribution of antigens in the cell as well as co-redistribution of immunological unrelated antigens [ 2 ]. (medsci.org)
- Results of studies in the experimental mouse model and in patients suggest that immune modulation with cytokines, such as interferon- , or with specific antigens could be used in the future to treat patients with alveolar echinococcosis and/or to prevent this very severe parasitic disease. (hindawi.com)
Proteins5
- studies on various types of antigenic proteins of fasciola spp. (academicjournals.org)
- Induction of antigenic modulation and complement activation by such autoantibodies leads to ultrastructural damage of the postsynaptic membrane and loss of AChR and associated proteins. (semanticscholar.org)
- for expressing antigenic proteins and making vaccines. (bioworld.com)
- The class II MHC genes encode proteins that present antigenic peptides to helper T cells, leading to T cell activation and the development of an antigen-specific immune response. (nih.gov)
- The system is involved in targeting many cellular proteins, among them cell cycle regulators, growth- and differentiation-controlling factors, transcriptional activators, cell-surface receptors and ion channels, endoplasmic reticulum proteins, antigenic proteins destined for presentation on class I MHC molecules, and abnormal/misfolded proteins. (nih.gov)
Addition to being ant1
- In addition to being antigenic, M. vaccae has immunogenic properties. (patentgenius.com)
Called antigenic variation1
- This diversity between strains in an immunodominant antigen is often called antigenic variation. (cdc.gov)
Determinants3
- antigenic modulation the alteration of antigenic determinants in a living cell surface membrane following interaction with antibody. (thefreedictionary.com)
- Differences in the antigenic determinants of N-CAMs from different neural tissues were detected by two independent monoclonal antibodies. (jneurosci.org)
- These hypothesized events can only occur if the MMR vaccine shares antigenic determinants that resemble secretin or any of its receptor types and remains to be studied. (greenmedinfo.com)
Measles virus infection1
- We have expanded the concept of antibody-induced antigenic modulation as an aid to understanding several persistent infections, with our primary interest in persistent measles virus infection of humans. (springer.com)
Antibody5
- The process, termed "antibody-induced antigenic modulation," was further investigated by using monoclonal antibody to several viral polypeptides. (scripps.edu)
- Gorman NT, Lachmann PJ (1982) In vitro modulation of viral cell surface glycoproteins by antiviral antibody in the presence of complement. (springer.com)
- Fujinami RS, Oldstone MBA (1980) Alterations in expression of measles virus polypeptides by antibody: Molecular events in antibody-induced antigenic modulation. (springer.com)
- Antibody modulation of expression and pathogen transcription levels has been described in virus. (medsci.org)
- Such an antibody may share antigenic determinant to molecules found in the gut. (greenmedinfo.com)
Mitogenic stimulation2
Monoclonal-antibodies2
- In the present study of the mouse and the chick, alterations of N-CAMs occurring as a result of E----A conversion, prevalence modulation, and changes in antigenic state during the development of different neural regions were analyzed by the use of highly specific polyclonal and monoclonal antibodies combined with anatomical dissection and several new quantitative assays. (jneurosci.org)
- Two major antigenic groups, groups A and B, of RS virus were originally delineated by their reactivities with monoclonal antibodies (MAbs) ( 3 , 19 ). (asm.org)
Lymphocyte2
- Antigenic modulation and abrogation of lymphocyte lysis of virus-infected cells. (springer.com)
- Studies reporting the role of EVs on T lymphocyte modulation are controversial. (frontiersin.org)
AChR2
- In the present studies we have used a mouse model of MG, termed experimental myasthenia gravis (EMG), to test the possibility that antigenic modulation of AChR may be the principle mechanism whereby this reduction in AChR density is achieved. (mysciencework.com)
- As the number of diagnosed patients increases, there is a need for the development of improved and specific therapeutic approaches for MG. Our studies involve mainly a) the thorough understanding of the antigenic structure of muscle AChR, b) the pathogenic mechanisms in MG, c) efforts to develop novel immunospecific therapeutic approaches and d) the better diagnosis of the disease. (pasteur.gr)
Characterization2
- Bjaring, B. and Klein, G.: Antigenic characterization of heterozygous mouse lymphomas after immunoselection in vivo . (springer.com)
- In addition to antigenic characterization with MAbs, these methods include restriction endonuclease analysis of small hydrophobic and nucleocapsid RS virus protein genes ( 8 ), restriction endonuclease analysis of G-protein gene cDNA ( 5 , 24 ), RNase protection analysis ( 11 , 21 ), and nucleotide sequence analysis of the G-protein gene ( 5 , 23 ). (asm.org)
Gene expression2
- The gene expression profile of preclinical autoimmune arthritis and its modulation by a tolerogenic disease-protective antigenic challenge. (scienceexchange.com)
- Manzano-Moreno FJ, Ramos-Torrecillas J, Melguizo-Rodríguez L, Illescas-Montes R, Ruiz C, García-Martínez O. Bisphosphonate Modulation of the Gene Expression of Different Markers Involved in Osteoblast Physiology: Possible Implications in Bisphosphonate-Related Osteonecrosis of the Jaw. (medsci.org)
Stimulation1
- In both diseases, it is suspected that there is a breakdown in mucosal tolerance to antigenic stimulation. (vin.com)
Antigen2
- The procedure of antigenic modulation showed that the MLr antigen resides on MTVgp52, the major protein of the envelope. (stanford.edu)
- Timo Burster, "Processing and Regulation Mechanisms within Antigen Presenting Cells: A Possibility for Therapeutic Modulation", Current Pharmaceutical Design (2013) 19: 1029. (eurekaselect.com)
Variation10
- These pathogens use antigenic variation to prolong their circulation in the blood and thus increase the likelihood of transmission. (cdc.gov)
- By convergent evolution, bacterial and protozoal vector-borne pathogens have acquired similar genetic mechanisms for successful antigenic variation. (cdc.gov)
- Antigenic variation poses a challenge in the development of vaccines against vector-borne pathogens. (cdc.gov)
- What is antigenic variation? (cdc.gov)
- One example of antigenic variation occurs in B. hermsii, a cause of tickborne relapsing fever (4) , which has a protein homologous to the OspC protein of B. burgdorferi. (cdc.gov)
- We review infectious pathogens that undergo clonal antigenic variation and, like B. hermsii, depend on arthropod vectors for transmission. (cdc.gov)
- Viruses are also said to have antigenic variation but are excluded from this review because the mechanism they use usually depends either on the accumulation of point mutations in a single genotype (e.g., the antigenic drift of influenza A virus) or on recombination or reassortment between two different genotypes infecting the same host (e.g., antigenic shift of influenza A virus). (cdc.gov)
- Recently, we have isolated several viruses related to HPRS-103 from cases of ML. Although these isolates showed properties of ALV subgroup J, the majority of them resisted neutralization by HPRS-103-specific serum, suggesting antigenic variation. (microbiologyresearch.org)
- Analysis of the data suggests that selection pressure, probably from the immune response, is driving the antigenic variation among the isolates. (microbiologyresearch.org)
- The epidemiological significance of the antigenic variation and the emergence of variant viruses are discussed. (microbiologyresearch.org)
Cell differentiation2
- Surface antigenic modulation occurring with cell differentiation can be monitored by specific antisera. (annals.org)
- IL-2 is required for T-cell proliferation, natural killer cells (NK) cytolytic activity, differentiation of regulatory T cells, modulation of T helper (Th) cell differentiation and activation-induced cell death. (abcam.com)
Variants2
- Since reactive oxygen species generated by PMN can be strong mutagens, the possibility of production of antigenic variants of the virus by virus-PMN interaction was investigated. (microbiologyresearch.org)
- Antigenic variants of J subgroup avian leukosis virus: sequence analysis reveals multiple changes in the env gene. (microbiologyresearch.org)
Immunoregulatory3
- International Patent Publication WO 91/01751 discloses the use of antigenic and/or immunoregulatory material from M. vaccae as animmunoprophylactic to delay and/or prevent the onset of AIDS. (patentgenius.com)
- International Patent Publication WO 94/06466 discloses the use of antigenic and/or immunoregulatory material derived from M. vaccae for therapy of HIV infection, with or without AIDS and withor without associated tuberculosis. (patentgenius.com)
- The immunoregulatory events described could participate in the modulation of immunopathology, the maintenance of chronic adult worm survival, and the prevention of full expression of protective immune responses. (ajtmh.org)
Surface4
- In this study, we investigated the relative importance of modulation and shaving in the downregulation of surface mAb:CD20. (jimmunol.org)
- Suppression of phagocytosis with bead treatment decreased shaving and increased modulation, suggesting that the two compete for surface rituximab:CD20. (jimmunol.org)
- However, in vivo binding of a therapeutic mAb to a cancer cell may also promote loss of the targeted Ag and bound mAb from the cell surface, an effect called antigenic modulation ( 2 , 3 , 19 , 20 ). (jimmunol.org)
- Several cell adhesion molecules involved in neuron-neuron and neuron- glia interactions have been identified in our laboratory and have been shown to undergo cell surface modulation. (jneurosci.org)
MAbs2
- Antigenic modulation described in previous reports may have been mediated by such shaving, and our findings may have profound implications for the use of mAbs in the immunotherapy of cancer. (jimmunol.org)
- Epidemiologic studies conducted in the United States with MAbs to define the antigenic groups showed that there are three types of RS virus epidemics: those in which group A or group B viruses were dominant and those in which both groups circulate concurrently ( 2 , 13 , 14 ). (asm.org)
Mechanisms1
- Both tolerance and immunopathology may be observed in Alveolar Echinococcosis (AE), the disease due to E. multilocularis [ 4 ], and most of the mechanisms occurring seem to be triggered by a sophisticated modulation born out of a stage-specific parasite metabolism and respective immunomodulating strategy. (hindawi.com)
Experimental2
- Work with experimental animals indicates that such interactions are sensitive to modulation by dopamine. (bioportfolio.com)
- Boyse EA, Old LJ, Luell S (1963) Antigenic properties of experimental leukemias. (springer.com)
Differentiation1
- Consequently, it is involved in regulating many basic cellular processes, such as cell cycle and division, growth and differentiation, signal transduction and transcription, modulation of the secretory and endocytic pathways, the immune and inflammatory responses, and quality control. (nih.gov)
Cells7
- Two explanations for this have been proposed: antigenic modulation whereby mAb:CD20 complexes are internalized in a B cell intrinsic process and shaving, in which mAb:CD20 complexes undergo trogocytic removal by effector cells, such as macrophages. (jimmunol.org)
- Similar CD2 m.RNA levels in anti-CD2 mAb treated and control cells show that down modulation of CD2 is the result of an alteration of translation or trafficking as opposed to a decrease in the level of transcription . (musc.edu)
- Such antigenic modulation can severely compromise therapeutic efficacy, and we postulated that B cells had been stripped (shaved) of the rituximab/CD20 complex by monocytes or macrophages in a reaction mediated by FcγR. (jimmunol.org)
- Monocytes and monocytic cell lines can efficiently induce antigenic modulation on certain mAb-targeted cancer cells ( 21 , 22 ). (jimmunol.org)
- Despite the capacity of monocytes and macrophages to internalize IgG-opsonized substrates ( 23 , 24 , 25 ), the mechanism of antigenic modulation promoted by monocytes has been generally presumed to be due to internalization of IgG Ab/target Ag immune complexes by the cancer cells, rather than by monocytes. (jimmunol.org)
- Figure 5: Analysis of TCR down-modulation in the dKO T cells. (nature.com)
- Antigenic modulation did not occur, and sustained reduction of circulating tumor cells was observed throughout the duration of the infusions. (bloodjournal.org)
Covalent1
- 1. An antigenic product, comprising a dendritic polymer, built on a core molecule which is at least difunctional so as to provide branching and containing up to 16 terminal functional groups to which an antigenic peptide, that comprises an epitope of a deposit-forming polypeptide involved in plaque-forming disease or disorder, is joined by covalent bonds. (freepatentsonline.com)
Glycoprotein1
- Immunofluorescence analysis of promastigote-specific glycoprotein gp46 and expression modulation analysis of the amastigote-specific A2 gene have revealed that concomitant exposure to temperature increase and acidification leads to amastigote-like forms. (biomedcentral.com)
Infection3
- Modulation of VZV replication by cutaneous innate immunity may avoid an incapacitating infection of the host that would limit opportunities for VZV transmission. (rupress.org)
- M vaccae is believed to contain antigenic compounds that are recognized by the immunesystem of individuals exposed to infection with M. tuberculosis and other infectious and/or inflammatory disorders. (patentgenius.com)
- The data indicate that during S. mansoni infection patients develop serum component(s) which specifically interfere with the responsiveness of their lymphocytes in regard to certain schistosome-derived antigenic preparations. (ajtmh.org)
Cytokines1
- Modulation of the enteric microenvironment has been shown to reduce proinflammatory mucosal cytokines in Crohn's disease (a disease in man similar to IBD in animals). (vin.com)
Peptide3
- The present invention relates to an antigenic product for inducing an immune response to a deposit-forming polypeptide, such as amyloid ss, which antigenic product is a multiple antigenic peptide (MAP) that contains multiple copies of an epitope of a deposit-forming polypeptide involved in a plaque-forming disease. (freepatentsonline.com)
- 2. The antigenic product of claim 1, wherein said dendritic polymer contains eight terminal functional groups to which an antigenic peptide is joined. (freepatentsonline.com)
- 7. The antigenic product of claim 5, wherein said antigenic peptide comprises the amino acid sequence of SEQ ID NO:1. (freepatentsonline.com)
Rituximab1
- Under all conditions tested, modulation predominated in rituximab loss, whereas shaving represented an epiphenomenon to phagocytosis. (jimmunol.org)
Mechanism3
- Therefore, shaving may represent an important mechanism of resistance when modulation is curtailed, and glycoengineering mAb to increase affinity for FcγR may enhance resistance because of shaving. (jimmunol.org)
- Because this effect occurred to the same extent in mice that developed severe paralysis and in those that gave no indication of muscular weakness, the role of antigenic modulation as a major pathologic mechanism in MG is questioned. (mysciencework.com)
- This modulation seems to be a necessary component of immunosuppression and the mechanism of this phenomenon was further defined in vitro . (musc.edu)
Viruses2
Induction1
- The data suggest that frequent oral antigenic exposure may eventually lead to induction of systemic immunity in tolerant mice. (asm.org)
Immunity1
- Anti-CD2 mAb suppresses cell mediated immunity in vivo with a concommittant down modulation of. (musc.edu)
Persistent1
- As replicating agents, they have the ability to serve as a persistent or increasing antigenic challenge. (springer.com)
Shift1
- Narayan O, Griffin DE, Chase J (1977) Antigenic shift of visna virus in persistently infected sheep. (springer.com)
Serum1
- These responses, induced by the schistosome-derived antigenic preparations, were suppressed if the homologous-normal serum supplement of the culture medium was replaced with either the patient's own (autologous) serum, or that of another S. mansoni patient. (ajtmh.org)
Molecules1
- Anti-CD2 mAb induces down modulation of CD2 and CD3 , demonstrating a functional association between these molecules . (musc.edu)
Markers1
- Antidepressant drugs are recommended for the treatment of Parkinson's disease (PD)-associated depression but their role in the modulation of L-DOPA-induced behavioral and neurochemical markers is poor. (bioportfolio.com)
Tuberculosis1
- No. 4,724,144 discloses an immunotherapeutic agent comprising antigenic material derived from M. vaccae fortreatment of mycobacterial diseases, especially tuberculosis and leprosy, and as an adjuvant to chemotherapy. (patentgenius.com)
Autoantibodies1
- E. Borda, D. Passafaro, S. Reina and L. Sterin-Borda, "Modulation of c-Jun NH 2 -Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren's Syndrome," Pharmacology & Pharmacy , Vol. 2 No. 4, 2011, pp. 256-265. (scirp.org)
Mice1
- Modulation of mice fecal microbiota by administration of casein. (pagepress.org)
Lymphocytes1
- [ 13 ] with orbital fibroblast modulation of T-cell lymphocytes. (medscape.com)
Genes1
- The specific objective was to evaluate the effect on osteoblasts of two nitrogen-containing BPs (zoledronate and alendronate) and one non-nitrogen-containing BP (clodronate) by analyzing modulations in their expression of genes essential for osteoblast physiology. (medsci.org)
Ineffective1
- The result of this antigenic modulation is that the cancer cell escapes and the therapy becomes ineffective. (jimmunol.org)
Response6
- This antigenic product can be formulated into an immunizing composition and used to elicit an immune response against a deposit-forming polypeptide involved in a plaque-forming disease or disorder. (freepatentsonline.com)
- Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). (genecards.org)
- In this review, we will discuss how stem cell-derived EVs may contribute toward the modulation of the immune response. (frontiersin.org)
- for use as an adjuvant in antigenic compositions that induce an immune response. (bioworld.com)
- It has been postulated that the onset of such autistic symptoms may involve an autoimmune response against the central nervous system and that the antigenic determinant could possibly be gastrointestinal in origin. (greenmedinfo.com)
- The modulation of development by secretin may be a static event possibly occurring at a specific time in early childhood development and if it involves an autoimmune response then a disruption in development may result. (greenmedinfo.com)
Regulation1
- Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). (genecards.org)
Functional1
- Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum. (bioportfolio.com)