Antigen-Antibody Complex
Antibodies
Immunoglobulin G
Immunoglobulin Fab Fragments
Carcinoembryonic Antigen
HLA Antigens
Antigen-Antibody Reactions
Antibody Specificity
Isoantibodies
Immunoglobulin Fragments
Hepatitis B Antibodies
Antigens, Neoplasm
Antigens, Surface
Antibody Formation
Hepatitis B Surface Antigens
Enzyme-Linked Immunosorbent Assay
Antibodies, Neutralizing
Fluorescent Antibody Technique
Antibody Affinity
Antigens, Protozoan
Binding Sites, Antibody
Antibodies, Anti-Idiotypic
Cross Reactions
Antigens, CD
Antigens, Polyomavirus Transforming
Molecular Sequence Data
Antigens, Helminth
Immunoglobulin M
Antibodies, Antinuclear
Antibodies, Neoplasm
Autoantibodies
Amino Acid Sequence
Immune Sera
T-Lymphocytes
Immunization
Antigens, Viral, Tumor
Neutralization Tests
HLA-DR Antigens
Receptors, Antigen, T-Cell
Rabbits
Immunoenzyme Techniques
Histocompatibility Antigens
Histocompatibility Antigens Class II
Antibodies, Bispecific
Receptors, Antigen, B-Cell
Hybridomas
B-Lymphocytes
Proliferating Cell Nuclear Antigen
Single-Chain Antibodies
O Antigens
Immunoglobulin A
Antigens, Tumor-Associated, Carbohydrate
Lymphocyte Activation
Antibodies, Blocking
Prostate-Specific Antigen
Antigens, CD15
Antigens, CD3
Cells, Cultured
Antibodies, Heterophile
Complement Fixation Tests
Blood Group Antigens
Antigens, CD8
Fluorescent Antibody Technique, Indirect
Epitope Mapping
Immunoassay
Base Sequence
Immunohistochemistry
HLA-A2 Antigen
Immunodiffusion
Blotting, Western
Electrophoresis, Polyacrylamide Gel
Hemagglutination Tests
Flow Cytometry
Antibodies, Catalytic
Antigens, CD4
Autoantigens
Immunization, Passive
Immunoblotting
Radioimmunoassay
Histocompatibility Antigens Class I
Antibodies, Monoclonal, Humanized
HLA-A Antigens
Sensitivity and Specificity
Antigens, CD45
Receptors, Antigen
Antigens, Differentiation
Hepatitis B Antigens
HLA-D Antigens
Antibodies, Antiphospholipid
Immunologic Techniques
Vaccination
Glycoproteins
Mice, Inbred Strains
Immunoelectrophoresis
Lymphocytes
HIV Antigens
Haptens
Peptides
Immunoglobulins
Hemagglutination Inhibition Tests
Cattle
Immunoglobulin Variable Region
Species Specificity
Recombinant Fusion Proteins
Antigens, CD1
Peptide Fragments
Immunity, Cellular
Cloning, Molecular
Dose-Response Relationship, Immunologic
Immunoglobulin Idiotypes
HLA-B Antigens
Tumor Cells, Cultured
Bacterial Vaccines
Agglutination Tests
Precipitin Tests
Vaccines, Synthetic
Interferon-gamma
Antigens, Heterophile
Antigens, CD19
Seroepidemiologic Studies
Peptide Library
Erythrocytes
Antigens, CD80
MART-1 Antigen
Hepatitis B Core Antigens
Membrane Proteins
Cytotoxicity, Immunologic
Complement System Proteins
Antigens, CD40
Epstein-Barr Virus Nuclear Antigens
Protein Binding
Autoimmune Diseases
CD4-Positive T-Lymphocytes
Adjuvants, Immunologic
Antibodies, Antineutrophil Cytoplasmic
T-Lymphocytes, Cytotoxic
Antigens, Thy-1
Binding, Competitive
Cell Membrane
Forssman Antigen
Microscopy, Electron
Dendritic Cells
Antigens, CD20
Immunity, Maternally-Acquired
Chromatography, Affinity
RNA, Messenger
Complement fixing hepatitis B core antigen immune complexes in the liver of patients with HBs antigen positive chronic disease. (1/4788)
One hundred and fifty-two biopsies from serologically HBsAg positive and negative patients with liver disease were studied in immunofluorescence: for the presence of the surface (HBs) and the core (HBc) antigenic determinants foeterminants of the hepatitis B virus, of immunoglobulins and complement (C) deposits, and for the capacity to fix human C. Circumstantial evidence is presented suggesting that HBc immune-complexes are a relevant feature in the establishment and progression of chronic HBSAg liver disease. C fixation by liver cells was shown in all HBC positive patients with chronic hepatitis; an active form was present in every case, except two with a persistent hepatitis, an inverse ratio of HBc to C binding fluorescence being noted between active chronic hepatitis and cirrhotic patients. HBc without C fixation was observed in only three patients in the incubation phase of infectious hepatitis. IgG deposits were often found in HBc containing, C fixing nuclei. No C binding or IgG deposits were observed in acute self-limited type B hepatitis, in serologically positive patients with normal liver or minimal histological lesions, with and without HBs cytoplasmic fluorescence in their biopsy, or in serologically negative individuals. (+info)Interaction of inflammatory cells and oral microorganisms. III. Modulation of rabbit polymorphonuclear leukocyte hydrolase release response to Actinomyces viscosus and Streptococcus mutans by immunoglobulins and complement. (2/4788)
In the absence of antiserum, rabbit polymorphonuclear leukocytes (PMNs) released lysosomal enzymes in response to Actinomyces viscosus (19246) but not to Streptococcus mutans (6715). Antibodies had a marked modulating influence on these reactions. PMN hydrolase release was significantly enhanced to both organisms when specific rabbit antiserum and isolated immunoglobulin G (IgG) were included in the incubations. Immune complex F(ab')2 fragments of IgG directed against S. mutans agglutinated bacteria. Immune complexes consisting of S. mutans and F(ab')2 fragments of IgG directed against this organism were not effective as bacteria-IgG complexes in stimulating PMN release. The intensity of the release response to bacteria-IgG complexes was also diminished when PMNs were preincubated with isolated Fc fragments derived from IgG. Fresh serum as a source of complement components had no demonstrable effect on PMN release either alone or in conjuction with antiserum in these experiments. These data may be relevant to the mechanisms and consequences of the interaction of PMNs and plaque bacteria in the pathogenesis of periodontal disease. (+info)Autoantibodies to RNA polymerases recognize multiple subunits and demonstrate cross-reactivity with RNA polymerase complexes. (3/4788)
OBJECTIVE: To determine the subunit specificity of autoantibody directed to RNA polymerases (RNAP) I, II, and III, which is one of the major autoantibody responses in patients with systemic sclerosis (SSc). METHODS: Thirty-two SSc sera with anti-RNAP antibodies (23 with anti-RNAP I/III, 5 with anti-RNAP I/III and II, and 4 with anti-RNAP II alone) were analyzed by immunoblotting using affinity-purified RNAP and by immunoprecipitation using 35S-labeled cell extracts in which RNAP complexes were dissociated. Antibodies bound to individual RNAP subunits were eluted from preparative immunoblots and were further analyzed by immunoblotting and immunoprecipitation. RESULTS: At least 15 different proteins were bound by antibodies in anti-RNAP-positive SSc sera in various combinations. All 9 sera immunoprecipitating RNAP II and all 28 sera immunoprecipitating RNAP I/III recognized the large subunit proteins of RNAP II and III, respectively. Reactivity to RNAP I large subunits was strongly associated with bright nucleolar staining by indirect immunofluorescence. Affinity-purified antibodies that recognized a 62-kd subunit protein cross-reacted with a 43-kd subunit protein and immunoprecipitated both RNAP I and RNAP III. Antibodies that recognized a 21-kd subunit protein obtained from sera that were positive for anti-RNAP I/III and II antibodies immunoprecipitated both RNAP II and RNAP III. CONCLUSION: Anti-RNAP antibodies recognize multiple subunits of RNAP I, II, and III. Moreover, the results of this study provide the first direct evidence that antibodies that recognize shared subunits of human RNAPs or epitopes present on different human RNAP subunits are responsible for the recognition of multiple RNAPs by SSc sera. (+info)Abnormal responses to rubella infection. (4/4788)
Two cases of rubella are described which caused initial problems in laboratory diagnosis due to abnormal features in the immune response. One patient presented with thrombocytopenic purpura and associated circulating immune complexes. The other patient, who was in early pregnancy, had an unusually prolonged rash and a delayed humoral immune response. The possible reasons for the difficulties in serological confirmation are discussed. (+info)Recognition of polynucleotides by antibodies to poly(I), poly(C). (5/4788)
The binding of anti poly(I). poly (C) Fab fragments to double or triple stranded polynucletides has been studied by fluorescence. Association constants were deduced from competition experiments. The comparison of the association constants leads to the conclusion that several atoms of the base residues do not interact with the amino acid residues of the binding site of Fab fragment while the hydroxyl groups of furanose rings interact. These results suggest that the Fab fragments do not bind to the major groove of the double stranded polynucleotides. An interaction between the C(2)O group of pyrimidine residues and Fab fragments cannot be excluded. Circular dichroism of poly(I). poly(C) or poly(I). poly(br5C)-Fab fragments complexes are very different from the circular dichroism of free polynucleotides which suggests a deformation of the polynucleotides bound to the Fab fragments. (+info)Association and dissociation kinetics of bobwhite quail lysozyme with monoclonal antibody HyHEL-5. (6/4788)
The anti-hen egg lysozyme monoclonal antibody HyHEL-5 and its complexes with various species-variant and mutant lysozymes have been the subject of considerable experimental and theoretical investigation. The affinity of HyHEL-5 for bobwhite quail lysozyme (BWQL) is over 1000-fold lower than its affinity for the original antigen, hen egg lysozyme (HEL). This difference is believed to arise almost entirely from the replacement in BWQL of the structural and energetic epitope residue Arg68 by lysine. In this study, the association and dissociation kinetics of BWQL with HyHEL-5 were investigated under a variety of conditions and compared with previous results for HEL. HyHEL-5-BWQL association follows a bimolecular mechanism and the dissociation of the antibody-antigen complex is a first-order process. Changes in ionic strength (from 27 to 500 mM) and pH (from 6.0 to 10.0) produced about a 2-fold change in the association and dissociation rates. The effect of viscosity modifiers on the association reaction was also studied. The large difference in the HEL and BWQL affinities for HyHEL-5 is essentially due to differences in the dissociation rate constant. (+info)Flexibility of the major antigenic loop of foot-and-mouth disease virus bound to a Fab fragment of a neutralising antibody: structure and neutralisation. (7/4788)
The interaction of foot-and-mouth disease virus (FMDV) serotype C (clone C-S8c1) with a strongly neutralising monoclonal antibody (MAb) 4C4 has been studied by combining data from cryoelectron microscopy and x-ray crystallography. The MAb 4C4 binds to the exposed flexible GH-loop of viral protein 1 (VP1), which appears to retain its flexibility, allowing movement of the bound Fab. This is in striking contrast to MAb SD6, which binds to the same GH-loop of VP1 but exhibits no movement of the bound Fab when observed under identical conditions. However, MAbs 4C4 and SD6 have very similar neutralisation characteristics. The known atomic structure of FMDV C-S8c1 and that of the 4C4 Fab cocrystallised with a synthetic peptide corresponding to the GH-loop of VP1 were fitted to the cryoelectron microscope density map. The best fit of the 4C4 Fab is compatible only with monovalent binding of the MAb in agreement with the neutralisation data on 4C4 MAbs, Fab2s, and Fabs. The position of the bound GH-loop is related to other known positions of this loop by a hinge rotation about the base of the loop. The 4C4 Fab appears to interact almost exclusively with the G-H loop of VP1, making no other contacts with the viral capsid. (+info)Induction of autoimmunity by multivalent immunodominant and subdominant T cell determinants of La (SS-B). (8/4788)
We investigated the consequences of altering the form and valence of defined autodeterminants on the initiation and spreading of experimentally induced La/Ro autoimmunity. Anti-La and Ro (SS-A) Ab responses were monitored following immunization of healthy mice with defined immunodominant and subdominant T cell determinants of the La (SS-B) autoantigen synthesized as either monomeric or multiple antigenic (MAP) peptides. Abs to mouse La (mLa) developed faster and were of higher titer in mice immunized with the subdominant mLa25-44 MAP compared with mice immunized with the 25-44 monomer. Rapid intermolecular spreading of the autoimmune response to 60-kDa Ro was observed in AKR/J mice immunized with mLa25-44 MAP, but not in mice immunized repeatedly with monomeric peptide. A/J mice immunized and boosted with the known tolerogenic mLa287-301 determinant delivered as monomeric peptide failed to develop Abs to either intact mLa or mLa287-301 peptide. However, immunization with the multivalent mLa287-301 peptide led to the rapid production of high titer mLa autoantibodies associated with a proliferative T cell response to the mLa287-301 peptide. The data suggested that the enhanced immunogenicity of MAPs was not due to augmented Ag presentation or T cell stimulation. However, MAP-, but not monomer peptide-, containing immune complexes were potent substrates for Ab-dependent fixation of complement. These results demonstrate that the form of Ag responsible for inducing autoimmunity can profoundly influence the nature and magnitude of the immune response. Thus, molecular mimicry of tolerogenic and nontolerogenic self determinants might trigger autoimmunity under conditions of altered valence. (+info)Examples of autoimmune diseases include:
1. Rheumatoid arthritis (RA): A condition where the immune system attacks the joints, leading to inflammation, pain, and joint damage.
2. Lupus: A condition where the immune system attacks various body parts, including the skin, joints, and organs.
3. Hashimoto's thyroiditis: A condition where the immune system attacks the thyroid gland, leading to hypothyroidism.
4. Multiple sclerosis (MS): A condition where the immune system attacks the protective covering of nerve fibers in the central nervous system, leading to communication problems between the brain and the rest of the body.
5. Type 1 diabetes: A condition where the immune system attacks the insulin-producing cells in the pancreas, leading to high blood sugar levels.
6. Guillain-Barré syndrome: A condition where the immune system attacks the nerves, leading to muscle weakness and paralysis.
7. Psoriasis: A condition where the immune system attacks the skin, leading to red, scaly patches.
8. Crohn's disease and ulcerative colitis: Conditions where the immune system attacks the digestive tract, leading to inflammation and damage to the gut.
9. Sjögren's syndrome: A condition where the immune system attacks the glands that produce tears and saliva, leading to dry eyes and mouth.
10. Vasculitis: A condition where the immune system attacks the blood vessels, leading to inflammation and damage to the blood vessels.
The symptoms of autoimmune diseases vary depending on the specific disease and the organs or tissues affected. Common symptoms include fatigue, fever, joint pain, skin rashes, and swollen lymph nodes. Treatment for autoimmune diseases typically involves medication to suppress the immune system and reduce inflammation, as well as lifestyle changes such as dietary changes and stress management techniques.
David Tyrrell (physician)
History of coronavirus
C1 complex
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Complement component 1q
Paxillus involutus
June Almeida
Prostate-specific antigen
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Immune complex
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Mary E. Costanza
Immunoglobulin superfamily
Colorimetry (chemical method)
Immunoassay
Peter Colman
Type III hypersensitivity
Complement fixation test
Macromolecular docking
Diffuse proliferative nephritis
C3b
Diphtheria vaccine
List of periodontal diseases
ELISA
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C4A
Complement component 4B
Centrifugal micro-fluidic biochip
Humoral immunity
Terry Pearson (immunologist)
Coronavirus nucleocapsid protein
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Paralytic illness of Franklin D. Roosevelt
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Uwe B. Sleytr
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CD151
HLA A1-B8-DR3-DQ2
Interleukin 3
Photopolymerization-based signal amplification
Mary Locke Petermann
List of immunologists
Pattern recognition receptor
COVID-19 pandemic in Indonesia
CoVLP
Liver support system
Cell-mediated immunity
Index of biochemistry articles
Estrogen receptor test
Polyarteritis nodosa
Immunosenescence
Scarlet fever
Caliciviridae
Vaccine hesitancy
Reverse phase protein lysate microarray
Function-spacer-lipid Kode construct
Results of search for 'su:{Antigen-antibody complex.}'
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Monoclonal antibody2
- Inter alia the appellant was asked to submit evidence in support of their statement that any three CDRs were sufficient to determine the binding specificity of an antibody, and that the CDR3 of the light and/or heavy variable chain of the claimed monoclonal antibody/fragment could be modified without distorting it's binding properties. (epo.org)
- We obtained for the first time a non-activating human IgG1κ anti-PR3 monoclonal antibody (mAb) named 4C3. (frontiersin.org)
Binds1
- CD64 binds IgG immune complex. (biolegend.com)
Reacts4
- This complex then reacts with fluorescein-labeled antibody. (cdc.gov)
- In this event, antigen adsorbed to the cells reacts with antibody in the presence of complement, causing cellular destruction. (cdc.gov)
- The X54-5/7.1 antibody reacts with mouse strains carrying CD64a and b alleles but not CD64d. (biolegend.com)
- Mouse monoclonal antibodies specific to Zaire Ebola virus GP, NP and VP40 - colloid gold conjugate reacts with the Zaire Ebola virus in the specimen. (who.int)
Serum4
- A sample was added to a reaction vessel with anti-thyroxine antibody, thyroxine-alkaline phosphatase conjugate, and paramagnetic particles coated with goat anti-mouse capture antibody and a stripping agent to dissociate all T4 from serum-binding proteins. (cdc.gov)
- f) Antitoxin: A solution of antibodies (e.g., diphtheria antitoxin and botulinum antitoxin) derived from the serum of animals immunized with specific antigens. (cdc.gov)
- Some of these antibodies are present in the patients' serum several years before the onset of clinical disease. (hindawi.com)
- A number of diseases are due to the systemic effects of immune complexes (antibodies linked to antigens) that arise in the appropriate response to an infection or in serum sickness, and these especially affect the kidneys, skin, and joints. (jrank.org)
Fluorescein-labeled1
- The walls of the bronchioles appeared rich in antigen, staining well with the fluorescein-labeled globulins isolated from patients with the disease. (cdc.gov)
Monocytes2
- Lymphocytes once triggered by immune complexes induced monocytes to synthesize the procoagulant product. (rupress.org)
- Indeed, all that appeared necessary to induce monocytes to produce procoagulant activity was an encounter with lymphocytes that had previously been in contact with soluble immune complexes. (rupress.org)
Protein12
- PROTEIN - PROTEIN INTERACTIONS Protein-protein interactions (PPIs) are the physical contacts between two or more proteins to perform complex biological functions. (slideshare.net)
- Hetero-trimeric G protein (Gα, Gβγ and GDP) Transient complexes When a protein interacts briefly and in a reversible manner with other proteins in only certain biochemical cascade, they form transient complexes. (slideshare.net)
- A sample is added to a reaction vessel with goat anti-hTSH-alkaline phosphatase conjugate, buffered protein solution, and paramagnetic particles coated with immobilized mouse monoclonal anti-hTSH antibody. (cdc.gov)
- Hence, new technologies that are capable of capturing whole protein complexes, yet providing atomic-level details for their structure and function, hold the potential to unravel the complexity of these interactions. (europeanpharmaceuticalreview.com)
- nMS begins with the isolation of protein complexes from their cellular environment and is followed by exchanging the analyte to an MS-compatible medium, while preserving the protein in its folded, native state. (europeanpharmaceuticalreview.com)
- Protein complexes are then ionised and transferred into the gas phase via soft ionisation methods such as electrospray ionisation. (europeanpharmaceuticalreview.com)
- Once inside the mass spectrometer, individual protein-ligand complexes can be isolated and dissociated to provide ligand identification or to quantify the stabilisation that ligands provide upon binding to the proteins. (europeanpharmaceuticalreview.com)
- As pharmaceutical scientists take on increasingly complex and more challenging novel targets - often involving more than one protein in a complex - the ability of nMS to inform on the binding, the conformational changes and strength of the binding, can be a powerful tool to advance drug discovery efforts. (europeanpharmaceuticalreview.com)
- These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen type II antibodies, antiglucose-6 phosphate isomerase antibodies, anticarbamylated protein antibodies, and antiacetylated protein antibodies) have different characteristics, diagnostic/prognostic value, and pathological significance in RA patients. (hindawi.com)
- In RA, an increased number of autoantibodies directed against these self-antigens such as rheumatoid factors (RF) and anticitrullinated protein antibody (ACPA) are commonly prevalent. (hindawi.com)
- Validated antibody for detection of endoplasmic reticulum protein calnexin by fluorescent western blot. (biotium.com)
- Immuno-AFM: Molecular recognition of protein-antibody complexes by direct AFM imaging. (nih.gov)
Neutralize3
- Antibodies are complex substances formed to neutralize or destroy these antigens in the blood. (digitalnaturopath.com)
- Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses. (mintz.com)
- The antibody tends to neutralize viruses or to bind to antigens, encouraging destruction of bacteria by white blood cells. (jrank.org)
Cellular3
- It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC). (biolegend.com)
- T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. (loinc.org)
- In the present study we define cellular participants and their roles in the procoagulant response to soluble immune complexes. (rupress.org)
Soluble2
- He has a particular emphasis on the use of immune complexes, a combination of soluble antigens and antibodies that can better interact with and activate cells of the immune system that soluble antigen alone, as vaccine immunogens. (nih.gov)
- It has previously been described that soluble antigen:antibody complexes in antigen excess can induce an increase in the procoagulant activity of human peripheral blood mononuclear cells. (rupress.org)
Antigenic2
- Benefits and risks are associated with using all immunobiologics (i.e., an antigenic substance or antibody-containing preparation). (cdc.gov)
- Immunobiologic: Immunobiologics include antigenic substances, such as vaccines and toxoids, or antibody-containing preparations, such as globulins and antitoxins, from human or animal donors. (cdc.gov)
Vaccines3
- These findings support the notion that the efficiency of vaccines in inducing long-lasting protective IgG is regulated predominantly by the amount of persisting (and presumably follicular dendritic cell-associated) antigen-antibody complexes. (ox.ac.uk)
- This paper explores the possibility that pneumococcal vaccines in particular, but perhaps other vaccines as well, contain antigens that might be cross-reactive with SARS-CoV-2 antigens. (mdpi.com)
- Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. (mintz.com)
Particle2
- The sample flows from an absorbent pad to a nitrocellulose membrane, passing through a reactive area containing monoclonal anti-PAMG-1 antibodies conjugated to a gold particle. (qiagen.com)
- T1", "T2" and "T3") and form a visible line as the antibody-antigen-antibody gold particle complex with high degree of sensitivity and specificity. (who.int)
Cross-reactive1
- Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages. (mintz.com)
Sodium azide1
- For lyophilized antibodies, we recommend reconstituting the antibody with glycerol and antimicrobial preservative like sodium azide for the longest shelf life (note that sodium azide is not compatible with HRP-conjugates). (biotium.com)
Induce1
- Antigens normally induce an immunoglobulin (Ig)G response which stays at an elevated level for several weeks or months, constituting an important part of the immunological memory. (ox.ac.uk)
Conjugates3
- As a consequence, nMS is finding applications in increasingly diverse research areas such as high-throughput drug screening, the study of amyloid formation and inhibition, the characterisation of antibody-drug conjugates and the elucidation of the interactions of membrane proteins with lipids and therapeutics. (europeanpharmaceuticalreview.com)
- The guaranteed shelf life from date of receipt for antibodies and conjugates is listed on the product information sheet. (biotium.com)
- Antibodies and other conjugates often are functional for significantly longer than the guaranteed shelf life. (biotium.com)
Vasculitis3
- Granulomatosis with polyangiitis (GPA) is a severe autoimmune vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA) mainly targeting proteinase 3 (PR3), a neutrophilic serine proteinase. (frontiersin.org)
- In vasculitis nomenclature, it is part of the group of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV): GPA is associated with cytoplasmic ANCA (cANCA), detected by immunofluorescence (IF) on fixed neutrophils ( 1 ). (frontiersin.org)
- Inflammation of the blood vessels (vasculitis) may be caused when antibodies that have attached to antigens in the blood (immune complexes), attach to the blood vessel walls. (medlineplus.gov)
Proteins4
- PPI Permanent complexes When an association between proteins is highly stable and need help from molecular switches to break them, they are permanent complexes. (slideshare.net)
- Interacting Complexes Obligate partners If proteins cannot exist in free form and only stable in multimeric association, they form obligate oligomers. (slideshare.net)
- Here, we show that antibodies against α-synuclein specifically target and aid in clearance of extracellular α-synuclein proteins by microglia, thereby preventing their actions on neighboring cells. (jneurosci.org)
- Michael Heidelberger (1888-1991) is known as one of the founders of quantitative immunochemistry, and in the course of his career studied, among others, bacterial polysaccharides (particularly pneumococcal), as well as the immunochemistry of proteins, antibodies, and antigens. (nih.gov)
Molecules1
- The complex formed by the binding of antigen and antibody molecules. (bvsalud.org)
Formation2
- Elucidation of the pathway may clarify the role of this lymphocyte-instructed monocyte response in the Shwartzman phenomenon and other thrombohemorrhagic events associated with immune cell function and the formation of immune complexes. (rupress.org)
- The antigen (foreign microorganism or other substance) provokes the formation of an antibody specific to that antigen. (jrank.org)
Anemia2
- Of pernicious anemia sufferers, 70% have these antibodies. (digitalnaturopath.com)
- 5% of subjects were anemia, diarrhea, hemarthrosis, hepatitis B surface antibody positive, nausea, and vomiting. (nih.gov)
Urine2
Hepatitis1
- e) Specific immune globulin: Special preparations obtained from blood plasma from donor pools preselected for a high antibody content against a specific antigen (e.g., hepatitis B immune globulin, varicella-zoster immune globulin, rabies immune globulin, tetanus immune globulin, vaccinia immune globulin, and cytomegalovirus immune globulin). (cdc.gov)
Structures2
- Complex odontomas include structures derived from individual tooth parts enamel, dentine, cementum and pulp. (ehd.org)
- During these fellowships, he determined the structures of influenza antigen:antibody complexes by X-ray crystallography and used this information to develop a flow cytometry method for single-cell cloning of broadly neutralizing antibodies. (mintz.com)
Tissues1
- His work also investigates mechanistically how these immune complexes traffic and engage with immune cells in lymphoid tissues. (nih.gov)
Complement2
- Both the activating and inhibitory Fc γ Rs and the activation of different complement cascades contribute to the downstream effector functions in the antibody-mediated disease pathology. (hindawi.com)
- The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. (nih.gov)
Cytotoxic1
- These immune complex immunogens have been shown to enhance the elicitation of cytotoxic T cell responses and redirect the antibody response away from non-protective epitopes. (nih.gov)
Vaccine1
- Active immunization is the production of antibody or other immune responses through the administration of a vaccine or toxoid. (cdc.gov)
Localization1
- Stereotaxic administration of antibody into the brains of α-synuclein tg mice prevented neuron-to-astroglia transmission of α-synuclein and led to increased localization of α-synuclein and the antibody in microglia. (jneurosci.org)
Elicitation1
- Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure. (mintz.com)
Infection2
- It is primarily used for replacement therapy in primary antibody-deficiency disorders, for the treatment of Kawasaki disease, immune thrombocytopenic purpura, hypogammaglobulinemia in chronic lymphocytic leukemia, and some cases of HIV infection. (cdc.gov)
- Antibody activity normally fights infection but can be damaging in allergies and a group of diseases that are called autoimmune diseases. (digitalnaturopath.com)
Passive3
- Passive immunization means the provision of temporary immunity by the administration of preformed antibodies. (cdc.gov)
- Furthermore, passive immunization with α-synuclein antibody reduced neuronal and glial accumulation of α-synuclein and ameliorated neurodegeneration and behavioral deficits associated with α-synuclein overexpression. (jneurosci.org)
- Passive immunity, the transfer of antibody-rich substances from an immune subject to a non-immune subject who is susceptible to disease, is important in infancy, where maternal antibodies protect the child until its own immune responses have matured. (jrank.org)
Fluorescent1
- The unattached fluorescent antibody is then removed by washing during centrifugation. (cdc.gov)
Tissue2
- It has been proposed that this response may explain the presence of fibrin in immune complex-mediated tissue lesions. (rupress.org)
- The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES . (bvsalud.org)
Exposure2
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. (biolegend.com)
- The procoagulant response was rapid, reaching a maximum within 6 h after exposure to antigen:antibody complexes. (rupress.org)
Specific2
- This study investigated factors influencing the level of neutralizing IgG titers against a virus and shows that within the range tested it was independent of the number of initially available and potentially responding T helper and B cells, but was regulated by the amount of specific IgG-immune complexes forming depots of persisting antigen. (ox.ac.uk)
- Thyroxine in the sample competed with the thyroxine-alkaline phosphatase conjugate for binding sites on a limited amount of specific anti-thyroxine antibody. (cdc.gov)
Species1
- Utilising this additional dimension of separation, it is possible to differentiate highly complex mixtures composed of species of equivalent mass, known as isobaric species, based on different conformations. (europeanpharmaceuticalreview.com)
Immune complex1
- Immune complex-induced human monocyte procoagulant activity. (rupress.org)
Disease1
- Make no mistake about it: your skin is a complex organ, one that consists of three layers that are optimally organized to protect you against disease and injury. (drbenkim.com)
Evaluate1
- Here we evaluate the involvement of ADAM10 in the process of antibody-induced podocyte injury. (lww.com)
Human3
- c) Immune globulin (IG): A sterile solution containing antibodies from human blood. (cdc.gov)
- Antibody to human albumin is covalently attached to derivatized polyacrylamide beads. (cdc.gov)
- Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. (mintz.com)
Commonly1
- The TME is commonly considered to be a complex ecosystem with immunosuppressive and tumor-promoting functions ( 4 - 6 ). (spandidos-publications.com)
Search1
- Results of search for 'su:{Antigen-antibody complex. (who.int)
Presence2
- One immunoglobulin was presented in the histiocytes, suggesting the antecedent presence of antigen-antibody complexes. (cdc.gov)
- The presence of PAMG-1 antigen is then detected by inserting a lateral flow test strip into the vial. (qiagen.com)
Mouse1
- Goat anti-mouse antibody is used to immobilize the mouse anti-hTSH antibody. (cdc.gov)
Target1
- and other target antigens [ 2 ]. (hindawi.com)
Solid phase1
- Resulting antigen:antibody complexes bound to the capture antibody on the solid phase. (cdc.gov)