Antifungal Agents
Candida
Amphotericin B
Echinocandins
Candida albicans
Fluconazole
Itraconazole
Ketoconazole
Candidiasis
Microbial Sensitivity Tests
Drug Resistance, Fungal
Fungi
Peptides, Cyclic
Aspergillus fumigatus
Ergosterol
Aspergillus
Nystatin
Clotrimazole
Drug Resistance, Multiple, Fungal
Candida glabrata
Cryptococcus neoformans
Trichophyton
Pyrimidines
Scedosporium
Arthrodermataceae
Natamycin
Pseudallescheria
Fungemia
Candidiasis, Oral
Sterol 14-Demethylase
Mitosporic Fungi
Yeasts
Lung Diseases, Fungal
Immunocompromised Host
Aspergillus flavus
Candida tropicalis
Onychomycosis
Mycetoma
Cryptococcus
Fusarium
Naphthalenes
Candidiasis, Invasive
Tinea
Madurella
Eye Infections, Fungal
Xylariales
Biofilms
Culture Media
Drug Resistance, Microbial
Blastomycosis
Fungicides, Industrial
Hyphae
Paecilomyces
Histatins
Opportunistic Infections
Mycology
Rhizopus
Sporotrichosis
Microsporum
Penicillium
Trichosporon
Mucormycosis
Fermentation
Fusariosis
Ascomycota
Indenes
Malassezia
Formazans
Molecular Structure
Trichosporonosis
Colorimetry
Sporothrix
Drug Evaluation, Preclinical
Tinea Pedis
Sterols
Colony Count, Microbial
Allylamine
Oils, Volatile
Meningitis, Fungal
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Aspergillosis, Allergic Bronchopulmonary
Pulmonary Aspergillosis
Microbial Viability
Saccharomyces cerevisiae
beta-Glucans
Peptides
Otitis Externa
Zygomycosis
Fungal Polysaccharides
Drug Interactions
Exophiala
AIDS-Related Opportunistic Infections
Mucorales
Tetrazolium Salts
Drug Combinations
Gene Expression Regulation, Fungal
Magnetic Resonance Spectroscopy
Drug Antagonism
Coccidioidomycosis
Plant Extracts
Molecular Sequence Data
Deoxycholic Acid
Disk Diffusion Antimicrobial Tests
Drug Therapy, Combination
Monoterpenes
Administration, Topical
Farnesol
Streptomyces
Cell Wall
Dose-Response Relationship, Drug
Lipoproteins
Lactones
Glucosyltransferases
Chromatography, High Pressure Liquid
Defensins
Structure-Activity Relationship
Rhizoctonia
Imidazoles
Oropharynx
Microscopy, Electron, Scanning
Microbial and chemical transformations of some 12,13-epoxytrichothec-9,10-enes. (1/8644)
Resting cells of Streptomyces griseus, Mucor mucedo, and a growing culture of Acinetobacter calcoaceticus when mixed with compounds related to 12,13-epoxytrichothec-9-ene-4beta,15-diacetoxy-3alpha-ol(anguidine) produced a series of derivatives that were either partially hydrolyzed or selectively acylated. These derivatives showed marked differences in activities as assayed by antifungal and tissue culture cytotoxicity tests. (+info)Early mycological treatment failure in AIDS-associated cryptococcal meningitis. (2/8644)
Cryptococcal meningitis causes significant morbidity and mortality in persons with AIDS. Of 236 AIDS patients treated with amphotericin B plus flucytosine, 29 (12%) died within 2 weeks and 62 (26%) died before 10 weeks. Just 129 (55%) of 236 patients were alive with negative cerebrospinal fluid (CSF) cultures at 10 weeks. Multivariate analyses identified that titer of cryptococcal antigen in CSF, serum albumin level, and CD4 cell count, together with dose of amphotericin B, had the strongest joint association with failure to achieve negative CSF cultures by day 14. Among patients with similar CSF cryptococcal antigen titers, CD4 cell counts, and serum albumin levels, the odds of failure at week 10 for those without negative CSF cultures by day 14 was five times that for those with negative CSF cultures by day 14 (odds ratio, 5.0; 95% confidence interval, 2.2-10.9). Prognosis is dismal for patients with AIDS-related cryptococcal meningitis. Multivariate analyses identified three components that, along with initial treatment, have the strongest joint association with early outcome. Clearly, more effective initial therapy and patient management strategies that address immune function and nutritional status are needed to improve outcomes of this disease. (+info)Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (3/8644)
The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia. (+info)Systemic candidiasis with candida vasculitis due to Candida kruzei in a patient with acute myeloid leukaemia. (4/8644)
Candida kruzei-related systemic infections are increasing in frequency, particularly in patients receiving prophylaxis with antifungal triazoles. A Caucasian male with newly diagnosed acute myeloid leukaemia (AML M1) developed severe and persistent fever associated with a micropustular eruption scattered over the trunk and limbs during induction chemotherapy. Blood cultures grew Candida kruzei, and biopsies of the skin lesions revealed a candida vasculitis. He responded to high doses of liposomal amphotericin B and was discharged well from hospital. (+info)Structure of the complex between the antibiotic cerulenin and its target, beta-ketoacyl-acyl carrier protein synthase. (5/8644)
In the biosynthesis of fatty acids, the beta-ketoacyl-acyl carrier protein (ACP) synthases catalyze chain elongation by the addition of two-carbon units derived from malonyl-ACP to an acyl group bound to either ACP or CoA. The enzyme is a possible drug target for treatment of certain cancers and for tuberculosis. The crystal structure of the complex of the enzyme from Escherichia coli, and the fungal mycotoxin cerulenin reveals that the inhibitor is bound in a hydrophobic pocket formed at the dimer interface. Cerulenin is covalently attached to the active site cysteine through its C2 carbon atom. The fit of the inhibitor to the active site is not optimal, and there is thus room for improvement through structure based design. (+info)BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties. (6/8644)
A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells. (+info)In vitro and in vivo activities of NS-718, a new lipid nanosphere incorporating amphotericin B, against Aspergillus fumigatus. (7/8644)
We evaluated the in vitro and in vivo potencies of a new lipid nanosphere that incorporates amphotericin B (AmB), NS-718, against Aspergillus fumigatus. The in vitro activity of NS-718 (the MIC at which 90% of strains are inhibited [MIC90], 0.25 microgram/ml) against 18 isolates of A. fumigatus was similar to that of deoxycholate AmB (D-AmB; Fungizone; MIC90, 0.25 microgram/ml), but NS-718 was more potent than liposomal AmB (L-AmB; AmBi-some; MIC90, 1.0 microgram/ml). The in vivo efficacy of NS-718 in a rat model of invasive pulmonary aspergillosis was compared with those of D-AmB and L-AmB. A low dose (1 mg/kg of body weight) of L-AmB was ineffective (survival rate, 0%), although equivalent doses of D-AmB and NS-718 were more effective (survival rate, 17%). However, a higher dose of NS-718 (3 mg/kg) was more effective (survival rate, 100%) than equivalent doses of D-AmB and L-AmB (survival rate, 0%). To explain these differences, pharmacokinetic studies showed higher concentrations of AmB in the plasma of rats treated with NS-718 than in the plasma of those treated with D-AmB. Our results suggest that NS-718, a new preparation of AmB, is a promising antifungal agent with activity against pulmonary aspergillosis. (+info)Effect of fasting on temporal variation in the nephrotoxicity of amphotericin B in rats. (8/8644)
Evidence for temporal variation in the nephrotoxicity of amphotericin B was recently reported in experimental animals. The role of food in these variations was determined by studying the effect of a short fasting period on the temporal variation in the renal toxicity of amphotericin B. Twenty-eight normally fed and 28 fasted female Sprague-Dawley rats were used. Food was available ad libitum to the fed rats, while the fasted animals were fasted 12 h before and 24 h after amphotericin B injection to minimize stress for the animals. Water was available ad libitum to both groups of rats, which were maintained on a 14-h light, 10-h dark regimen (light on at 0600 h). Renal toxicity was determined by comparing the levels of excretion of renal enzyme and the serum creatinine and blood urea nitrogen (BUN) levels at the time of the maximal (0700 h) or the minimal (1900 h) nephrotoxicity after the intraperitoneal administration of a single dose of dextrose (5%; control group) or amphotericin B (50 mg/kg of body weight; treated group) to the rats. The nephrotoxicities obtained after amphotericin B administration at both times of day were compared to the nephrotoxicities observed for time-matched controls. In fed animals, the 24-h urinary excretion of N-acetyl-beta-D-glucosaminidase and beta-galactosidase was significantly higher when amphotericin B was injected at 0700 and 1900 h. The excretion of these two enzymes was reduced significantly (P < 0.05) in fasting rats, and this effect was larger at 0700 h (P < 0.05) than at 1900 h. The serum creatinine level was also significantly higher (P < 0.05) in fed animals treated at 0700 h than in fed animals treated at 1900 h. Fasting reduced significantly (P < 0.05) the increase in the serum creatinine level, and this effect was larger in the animals treated at 0700 h. Similar data were obtained for BUN levels. Amphotericin B accumulation was significantly higher (P < 0.05) in the renal cortexes of fed rats than in those of fasted animals, but there was no difference according to the time of injection. These results demonstrated that fasting reduces the nephrotoxicity of amphotericin B and that food availability is of crucial importance in the temporal variation in the renal toxicity of amphotericin B in rats. (+info)The most common types of mycoses include:
1. Ringworm: This is a common fungal infection that causes a ring-shaped rash on the skin. It can affect any part of the body, including the arms, legs, torso, and face.
2. Athlete's foot: This is a common fungal infection that affects the feet, causing itching, redness, and cracking of the skin.
3. Jock itch: This is a fungal infection that affects the groin area and inner thighs, causing itching, redness, and cracking of the skin.
4. Candidiasis: This is a fungal infection caused by Candida, a type of yeast. It can affect various parts of the body, including the mouth, throat, and vagina.
5. Aspergillosis: This is a serious fungal infection that can affect various parts of the body, including the lungs, sinuses, and brain.
Symptoms of mycoses can vary depending on the type of infection and the severity of the infection. Common symptoms include itching, redness, swelling, and cracking of the skin. Treatment for mycoses usually involves antifungal medications, which can be applied topically or taken orally. In severe cases, hospitalization may be necessary to monitor and treat the infection.
Preventive measures for mycoses include practicing good hygiene, avoiding sharing personal items such as towels and clothing, and using antifungal medications as prescribed by a healthcare professional. Early diagnosis and treatment of mycoses can help prevent complications and reduce the risk of transmission to others.
Types of candidiasis:
1. Vulvovaginal candidiasis (VVC): a common infection that affects the vagina and vulva; symptoms include itching, burning, and abnormal discharge.
2. Oral thrush (OT): an infection that affects the mouth, often seen in infants and people with weakened immune systems; symptoms include white patches on the tongue and inside the cheeks.
3. Invasive candidiasis (IC): a severe infection that can spread throughout the body, often seen in people with weakened immune systems, such as those with HIV/AIDS or undergoing chemotherapy; symptoms include fever, chills, and difficulty breathing.
4. Candidal balanitis: an infection of the foreskin and glans of the penis; symptoms include redness, swelling, and pain.
5. Diaper rash: a common skin infection that affects infants who wear diapers; symptoms include redness, swelling, and irritability.
Causes and risk factors:
1. Overgrowth of Candida fungus due to an imbalance of the normal flora.
2. Use of antibiotics or steroids that can disrupt the balance of the body's natural flora.
3. Weakened immune system, such as in people with HIV/AIDS or undergoing chemotherapy.
4. Poor hygiene and sanitation.
5. Diabetes mellitus.
6. Pregnancy.
7. Obesity.
Diagnosis:
1. Physical examination and medical history.
2. Microscopic examination of a scraping or biopsy specimen.
3. Cultures of skin, blood, or other body fluids.
4. Polymerase chain reaction (PCR) or other molecular diagnostic techniques to detect the presence of the fungus.
Treatment:
1. Topical antifungal medications, such as clotrimazole, miconazole, or terbinafine, applied directly to the affected area.
2. Oral antifungal medications, such as fluconazole or itraconazole, for more severe infections or those that do not respond to topical treatment.
3. Antibiotics if there is a secondary bacterial infection.
4. Supportive care, such as pain management and wound care.
5. Proper hygiene and sanitation practices.
6. In severe cases, hospitalization may be necessary for intravenous antifungal medications and close monitoring.
Prevention:
1. Practice good hygiene and sanitation.
2. Avoid sharing personal items, such as towels or clothing.
3. Wash hands before touching the affected area.
4. Keep the affected area clean and dry.
5. Use of antifungal powders or sprays on the affected area.
6. Avoid using harsh soaps or cleansers that can irritate the skin.
7. Wear shoes in public areas to prevent exposure to fungal spores.
8. Avoid sharing bathing or showering facilities with others.
9. Dry thoroughly after bathing or swimming.
10. Use of antifungal medications as a prophylactic measure in high-risk individuals, such as those with weakened immune systems.
It's important to note that the best treatment and prevention strategies will depend on the specific type of fungus causing the infection, as well as the severity and location of the infection. It is essential to consult a healthcare professional for proper diagnosis and treatment.
The symptoms of aspergillosis depend on the location and severity of the infection. In the lungs, it may cause coughing, fever, chest pain, and difficulty breathing. In the sinuses, it can cause headaches, facial pain, and nasal congestion. In the brain, it can cause seizures, confusion, and weakness.
Aspergillosis is typically diagnosed through a combination of imaging tests such as chest X-rays, CT scans, and MRI scans, along with a biopsy to confirm the presence of Aspergillus fungi.
Treatment of aspergillosis depends on the severity and location of the infection. In mild cases, treatment may involve antifungal medications and supportive care such as oxygen therapy and pain management. In severe cases, treatment may require hospitalization and intravenous antifungal medications.
Preventive measures for aspergillosis include avoiding exposure to dusty or damp environments, managing chronic conditions such as asthma and COPD, and taking antifungal medications as prescribed.
Aspergillosis can be a serious condition, especially in people with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive drugs. In severe cases, aspergillosis can lead to life-threatening complications such as respiratory failure, sepsis, and organ damage.
In conclusion, aspergillosis is a common fungal infection that can affect various parts of the body, and it can be serious and potentially life-threatening, especially in people with weakened immune systems. Early diagnosis and appropriate treatment are essential to prevent complications and improve outcomes.
Candidemia can cause a range of symptoms, including fever, chills, rapid heart rate, and confusion. In severe cases, it can lead to organ failure and death. Treatment typically involves the use of antifungal medications, and in some cases, hospitalization is necessary to manage the infection and monitor the patient's condition.
Preventative measures to reduce the risk of developing candidemia include proper handwashing and hygiene, avoiding close contact with people who are sick, and ensuring that medical equipment and surfaces are properly cleaned and disinfected. Early detection and treatment can significantly improve outcomes for patients with candidemia.
Also found in: Medical, Encyclopedia.
Examples from the web for 'dermatomycoses'
Some common types of dermatomycoses include athlete's foot and jock itch.
Scientific American, 25 Mar. 2019.
Topical antifungal medications are effective against most types of dermatomycoses.
Britannica.com: encyclopedia article about dermatomycoses.
This condition is caused by a type of fungus that affects the skin, known as dermatomycoses.
Mayo Clinic, 01 Mar. 2020.
Symptoms of fungemia may include fever, chills, night sweats, fatigue, and weight loss. Diagnosis is typically made by drawing blood cultures and performing microbiological tests to identify the presence of fungal organisms in the blood. Treatment typically involves administration of antifungal medications, which can be given intravenously or orally. In severe cases, hospitalization may be necessary to monitor and treat the condition.
In some cases, fungemia can lead to complications such as sepsis, organ failure, and death. Prompt diagnosis and treatment are essential to prevent these outcomes.
The infection is usually caused by an overgrowth of Candida, which is a normal flora in the mouth, but can become pathogenic under certain conditions. Risk factors for developing OC include taking antibiotics, wearing dentures, pregnancy, diabetes, and HIV/AIDS.
OC can be diagnosed by examining the mouth and throat with a mirror and torch, as well as through laboratory tests such as cultures or PCR. Treatment typically involves antifungal medication, good oral hygiene practices, and addressing any underlying conditions. In severe cases, hospitalization may be necessary.
Preventative measures include practicing good oral hygiene, avoiding smoking, and managing any underlying medical conditions. In addition, early diagnosis and treatment can help prevent the infection from spreading to other parts of the body, such as the bloodstream or heart.
The symptoms of cryptococcosis vary depending on the location and severity of the infection. In lung infections, patients may experience fever, cough, chest pain, and difficulty breathing. In CNS infections, patients may experience headaches, confusion, seizures, and loss of coordination. Skin infections can cause skin lesions, and eye infections can cause vision problems.
Cryptococcosis is diagnosed by culturing the fungus from body fluids or tissue samples. Treatment typically involves antifungal medications, such as amphotericin B or fluconazole, which may be given intravenously or orally, depending on the severity and location of the infection. In severe cases, surgery may be required to remove infected tissue or repair damaged organs.
Preventive measures for cryptococcosis include avoiding exposure to fungal spores, practicing good hygiene, and maintaining a healthy immune system. For individuals with HIV/AIDS, antiretroviral therapy can help reduce the risk of developing cryptococcosis.
Overall, while rare, cryptococcosis is a serious opportunistic infection that can affect individuals with compromised immune systems. Early diagnosis and prompt treatment are essential to prevent complications and improve outcomes.
Causes:
The most common cause of candidiasis is an imbalance in the natural bacteria and yeast that live in and around the vagina. This imbalance can be caused by a variety of factors, including:
* Taking antibiotics, which can kill off the "good" bacteria that keep candida in check
* Pregnancy and menopause, when hormonal changes can lead to an overgrowth of yeast
* Diabetes, which can cause excess sugar in the body that feeds the growth of yeast
* Weakened immune system
* Poor hygiene or poor fitting clothing and underwear that can trap moisture and create a warm environment for yeast to grow.
Symptoms:
The symptoms of candidiasis can vary from person to person, but common signs include:
* Itching, burning, and redness of the vulva and vagina
* A thick, white discharge that looks like cottage cheese and has no odor or a mild, sweet smell
* Pain or discomfort during sex
* Difficulty getting pregnant (infertility) if the infection is severe or recurrent.
Diagnosis:
A healthcare provider can diagnose candidiasis by performing a physical examination and taking a sample of vaginal discharge for testing. The provider may also take a culture of the yeast to determine which type of candida is causing the infection.
Treatment:
Candidiasis can be treated with antifungal medications, such as clotrimazole or terconazole. These medications are available over-the-counter or by prescription and come in creams, tablets, or suppositories. To help clear the infection, treatment may also include:
* Avoiding irritants such as douches, powders, or scented soaps
* Wearing loose-fitting clothing and cotton underwear
* Keeping the genital area clean and dry
* Avoiding sex during treatment
Complications:
If left untreated, candidiasis can lead to complications such as:
* Recurrent infections
* Inflammation of the vulva (vulvodynia)
* Inflammation of the vagina (vaginitis)
* Pain during sex
* Difficulty getting pregnant (infertility)
Prevention:
To prevent candidiasis, women can take the following steps:
* Practice good hygiene by washing the genital area gently with soap and water
* Avoid using douches, powders, or scented soaps
* Wear loose-fitting clothing and cotton underwear
* Change out of wet or sweaty clothes as soon as possible
* Avoid sex during treatment for candidiasis.
Prognosis:
With proper treatment, the prognosis for candidiasis is good. The infection usually clears up within a week or two with antifungal medication. However, recurrent infections can be more difficult to treat and may require longer courses of therapy. In some cases, candidiasis can lead to complications such as inflammation of the vulva or vagina, which can be more challenging to treat.
It is important for women to seek medical attention if they experience any symptoms of candidiasis, as early diagnosis and treatment can help prevent complications and improve outcomes.
Types of fungal lung diseases include:
1. Aspergillosis: This is an infection caused by the fungus Aspergillus, which is commonly found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive drugs.
2. Cryptococcosis: This is an infection caused by the fungus Cryptococcus neoformans, which is found in soil and decaying wood. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
3. Histoplasmosis: This is an infection caused by the fungus Histoplasma capsulatum, which is found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
4. Pneumocystis pneumonia (PCP): This is an infection caused by the fungus Pneumocystis jirovecii, which is found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
5. Sporotrichosis: This is an infection caused by the fungus Sporothrix schenckii, which is found in soil and decaying organic matter. It can affect people with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs.
Symptoms of fungal lung diseases can include:
* Cough
* Fever
* Chest pain
* Shortness of breath
* Fatigue
Diagnosis of fungal lung diseases is typically made through a combination of physical examination, medical history, and laboratory tests such as chest X-rays, CT scans, and fungal cultures. Treatment usually involves antifungal medications and may also include supportive care to manage symptoms.
Prevention of fungal lung diseases includes:
1. Avoiding exposure to fungal spores by wearing protective clothing and gear when working with soil or decaying organic matter.
2. Maintaining good indoor air quality by using ventilation systems and reducing humidity.
3. Reducing the risk of infection by avoiding close contact with people who are at high risk of developing fungal lung diseases, such as those with weakened immune systems.
4. Avoiding smoking and other tobacco products, which can increase the risk of developing fungal lung diseases.
5. Managing underlying medical conditions, such as HIV/AIDS or taking immunosuppressive drugs, to reduce the risk of developing fungal lung diseases.
The condition can affect anyone, but it is more common in older adults and people with certain underlying health conditions such as diabetes, circulatory problems, and immune deficiency disorders. It can also be a side effect of certain medications or a result of exposure to fungal spores in the environment.
There are several types of onychomycosis, including:
1. Distal lateral subungual onychomycosis: This is the most common type and affects the nails of the big toe and thumb.
2. Proximal subungual onychomycosis: This type affects the nails of the fingertips and toes.
3. White superficial onychomycosis: This type is characterized by a white, patchy appearance on the surface of the nail.
4. Candidal onychomycosis: This type is caused by a yeast infection and is more common in people with diabetes or compromised immune systems.
Onychomycosis can be diagnosed through a physical examination, medical history, and fungal cultures of the nail. Treatment options include topical creams and ointments, oral medications, and laser therapy. The best treatment approach depends on the severity and location of the infection, as well as the individual's overall health status.
Preventative measures for onychomycosis include keeping the nails clean and dry, avoiding sharing personal care items, wearing socks that absorb sweat, and using antifungal sprays or powders. Good hygiene practices and regular check-ups with a healthcare provider can also help prevent and manage onychomycosis.
The symptoms of mycetoma can vary depending on the type of pathogen causing the infection, but they typically include:
* Swelling and redness of the affected area
* Pain or tenderness to the touch
* Skin thickening and hardening
* Ulceration and discharge of pus
* Fever and malaise
Mycetoma can be difficult to diagnose, as the symptoms can be similar to those of other skin conditions. However, a biopsy of the affected tissue can help to confirm the diagnosis by revealing the presence of granulomas and the pathogen responsible for the infection.
Treatment of mycetoma typically involves antibiotics or antifungal medications, which can help to clear the infection and reduce symptoms. In severe cases, surgical debridement of the affected tissue may be necessary to remove the infected area.
Prevention of mycetoma is challenging, as it is often caused by environmental factors such as soil and water contamination. However, maintaining good wound care and hygiene practices can help to reduce the risk of infection. Early diagnosis and treatment can also help to prevent the spread of the infection and reduce the risk of complications.
Overall, mycetoma is a chronic and debilitating condition that can have a significant impact on quality of life. While it can be challenging to diagnose and treat, early detection and appropriate management can help to improve outcomes for patients affected by this condition.
Candidiasis, invasive is caused by the overgrowth of Candida in the body, which can occur for a variety of reasons, such as:
* Weakened immune system due to HIV/AIDS, cancer, or medications that suppress the immune system.
* Invasive medical devices, such as central lines or implanted pacemakers.
* Previous history of invasive candidiasis.
* Pregnancy.
* Intravenous drug use.
The symptoms of candidiasis, invasive can vary depending on the organs affected, but may include:
* Fever.
* Chills.
* Shortness of breath.
* Pain in the abdomen or chest.
* Confusion or disorientation.
* Skin rash or lesions.
Diagnosis of candidiasis, invasive is based on a combination of physical examination, medical history, and laboratory tests, such as blood cultures and imaging studies. Treatment typically involves the use of antifungal medications, which may be given intravenously or orally, depending on the severity of the infection. In severe cases, hospitalization may be necessary to monitor and treat the infection.
Prevention of candidiasis, invasive includes:
* Proper hygiene and handwashing practices.
* Avoiding close contact with individuals who have invasive candidiasis.
* Avoiding sharing of personal items, such as toothbrushes or razors.
* Avoiding the use of invasive medical devices, if possible.
* Proper care and maintenance of medical devices.
* Monitoring for signs of infection in individuals with weakened immune systems.
In conclusion, candidiasis, invasive is a serious and potentially life-threatening fungal infection that can affect various organs and systems in the body. Early diagnosis and treatment are crucial to prevent complications and improve outcomes. Proper prevention and control measures can help reduce the risk of developing invasive candidiasis.
There are several types of tinea, including:
1. Tinea corporis (ringworm): This is one of the most common forms of tinea, characterized by itchy, circular patches on the skin.
2. Tinea pedis (athlete's foot): This type of tinea affects the feet and causes itching, burning, and flaking skin.
3. Tinea capitis (ringworm of the scalp): This type of tinea affects the scalp and can cause hair loss, itching, and scaling.
4. Tinea barbae (beard ringworm): This type of tinea affects the beard area and can cause itching, redness, and flaking skin.
5. Tinea cruris (jock itch): This type of tinea affects the groin area and can cause itching, redness, and flaking skin.
Tinea is usually treated with antifungal medications, which are applied topically or taken orally. In some cases, the infection may need to be removed surgically. It is important to seek medical attention if symptoms persist or worsen over time, as tinea can lead to complications such as skin thickening and discoloration.
Preventive measures include maintaining good hygiene, avoiding sharing personal items, and wearing loose-fitting clothing that allows for good airflow. In addition, using antifungal powders or sprays can help prevent the development of tinea.
There are several types of fungal eye infections, including:
1. Aspergillosis: This is a common type of fungal infection that affects the eye. It is caused by the fungus Aspergillus and can occur in people with weakened immune systems or pre-existing eye conditions.
2. Candidemia: This is another common type of fungal infection that affects the eye. It is caused by the fungus Candida and can occur in people with weakened immune systems or pre-existing eye conditions.
3. Cryptococcosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Cryptococcus and can occur in people with weakened immune systems, such as those with HIV/AIDS.
4. Histoplasmosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Histoplasma and can occur in people who have been exposed to the fungus in soil or bird droppings.
5. Blastomycosis: This is a rare type of fungal infection that affects the eye. It is caused by the fungus Blastomyces and can occur in people who have been exposed to the fungus in soil or water.
Fungal eye infections can cause a range of symptoms, including redness, discharge, pain, and vision loss. Treatment typically involves antifungal medication and may also include surgery to remove any infected tissue. In severe cases, fungal eye infections can lead to blindness if left untreated.
Prevention measures for fungal eye infections include good hygiene practices, such as washing hands regularly and avoiding close contact with people who have the infection. People with weakened immune systems should also avoid exposure to fungi by avoiding outdoor activities during peak fungal growth seasons and wearing protective clothing when working or playing in areas where fungi are likely to be present.
Overall, fungal eye infections are uncommon but can be serious conditions that require prompt medical attention. If you suspect you may have a fungal eye infection, it is important to seek medical care as soon as possible to receive proper diagnosis and treatment.
The fungus is found in soil and water and is typically contracted through the inhalation of contaminated dust or the ingestion of contaminated food or water. The symptoms of blastomycosis can vary depending on the severity of the infection, but may include:
* Fever
* Cough
* Shortness of breath
* Skin lesions
* Joint pain
* Swollen lymph nodes
In severe cases, blastomycosis can lead to life-threatening complications such as respiratory failure, cardiovascular problems, and meningitis.
Diagnosis of blastomycosis is based on a combination of clinical findings, laboratory tests, and imaging studies. Treatment typically involves antifungal medications, which can be effective in resolving symptoms and preventing complications. However, the disease can be challenging to diagnose and treat, and long-term follow-up is often necessary to ensure that the infection has been fully cleared.
Preventive measures for blastomycosis include avoiding contact with contaminated soil and water, wearing protective clothing and equipment when working outdoors in areas where the fungus is prevalent, and taking antifungal medications as prescribed by a healthcare provider. Early diagnosis and treatment are critical to preventing severe complications and improving outcomes for patients with blastomycosis.
Examples of OIs include:
1. Pneumocystis pneumonia (PCP): A type of pneumonia caused by the fungus Pneumocystis jirovecii, which is commonly found in the lungs of individuals with HIV/AIDS.
2. Cryptococcosis: A fungal infection caused by Cryptococcus neoformans, which can affect various parts of the body, including the lungs, central nervous system, and skin.
3. Aspergillosis: A fungal infection caused by Aspergillus fungi, which can affect various parts of the body, including the lungs, sinuses, and brain.
4. Histoplasmosis: A fungal infection caused by Histoplasma capsulatum, which is commonly found in the soil and can cause respiratory and digestive problems.
5. Candidiasis: A fungal infection caused by Candida albicans, which can affect various parts of the body, including the skin, mouth, throat, and vagina.
6. Toxoplasmosis: A parasitic infection caused by Toxoplasma gondii, which can affect various parts of the body, including the brain, eyes, and lymph nodes.
7. Tuberculosis (TB): A bacterial infection caused by Mycobacterium tuberculosis, which primarily affects the lungs but can also affect other parts of the body.
8. Kaposi's sarcoma-associated herpesvirus (KSHV): A viral infection that can cause various types of cancer, including Kaposi's sarcoma, which is more common in individuals with compromised immunity.
The diagnosis and treatment of OIs depend on the specific type of infection and its severity. Treatment may involve antibiotics, antifungals, or other medications, as well as supportive care to manage symptoms and prevent complications. It is important for individuals with HIV/AIDS to receive prompt and appropriate treatment for OIs to help prevent the progression of their disease and improve their quality of life.
If left untreated, sporotrichosis can progress to more serious complications such as bone infections, meningitis, or other life-threatening conditions. Treatment typically involves the use of antifungal medications and surgical debridement of infected tissue.
Sporotrichosis has been associated with a number of risk factors including rural living, outdoor work, and contact with soil or contaminated objects. In some cases, sporotrichosis may also be transmitted through inhalation of fungal spores.
Prevention measures include avoiding activities that involve exposure to soil or other potential sources of the fungus, wearing protective clothing and equipment when working outdoors, and taking precautions such as washing hands regularly to reduce the risk of infection.
Mucormycosis is a relatively rare disease, but it can be severe and potentially life-threatening. The symptoms of mucormycosis can vary depending on the location of the infection, but they may include fever, fatigue, pain, swelling, and redness at the site of the infection.
Mucormycosis is usually diagnosed through a combination of physical examination, laboratory tests, and imaging studies such as X-rays or CT scans. Treatment typically involves surgical removal of the infected tissue and antifungal medications. In severe cases, hospitalization and intensive care may be necessary.
Prevention of mucormycosis involves avoiding exposure to fungal spores, keeping wounds clean and dry, and seeking medical attention if signs of infection are present. People with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive medications, are at higher risk for developing mucormycosis and should take extra precautions to avoid exposure to fungal spores.
In conclusion, mucormycosis is a rare but potentially serious fungal infection that can affect various parts of the body. It is important to be aware of the risk factors and symptoms of mucormycosis, and to seek medical attention promptly if suspected. With early diagnosis and appropriate treatment, the prognosis for mucormycosis is generally good.
1. Cutaneous fusariosis: This type of infection affects the skin and subcutaneous tissues, causing ulcers, nodules, and plaques.
2. Osteoarticular fusariosis: This type of infection affects the bones and joints, causing pain, swelling, and limited mobility.
3. Fusariosis sinusitis: This type of infection affects the paranasal sinuses and can cause chronic rhinosinusitis, meningitis, and ocular involvement.
4. Fusariosis pneumonia: This type of infection affects the lungs and can cause fever, cough, and difficulty breathing.
5. Fusariosis disseminated: This type of infection affects multiple organs and tissues, including the skin, bones, joints, lungs, and central nervous system.
The signs and symptoms of fusariosis can vary depending on the severity and location of the infection, but common symptoms include:
* Skin lesions such as ulcers, nodules, and plaques
* Joint pain and swelling
* Bone pain and limited mobility
* Fever
* Cough
* Difficulty breathing
* Headache
* Fatigue
* Weight loss
The diagnosis of fusariosis is based on a combination of clinical findings, laboratory tests, and imaging studies. Laboratory tests may include:
* Blood cultures: to isolate the fungus from the blood
* Skin or tissue biopsy: to confirm the presence of the fungus in the affected tissue
* Imaging studies such as X-rays, CT scans, or MRI scans: to evaluate the extent of the infection
Treatment of fusariosis is challenging and requires a multidisciplinary approach. The primary goal of treatment is to manage symptoms, prevent complications, and improve quality of life. Treatment options include:
* Antifungal medications: to target the fungus and prevent its growth
* Pain management: to control pain and discomfort
* Wound care: to promote healing of skin lesions and prevent further injury
* Physical therapy: to maintain joint mobility and strength
* Respiratory support: to manage respiratory symptoms
* Nutritional support: to ensure adequate nutrition and hydration
The prognosis for patients with fusariosis is generally poor, with high mortality rates reported in some cases. However, with early diagnosis, appropriate treatment, and close monitoring, some patients may experience improved symptoms and quality of life. It is important to note that the risk of recurrence is high in patients with fusariosis, and ongoing management and surveillance are often necessary to prevent further infections.
Prevention of fusariosis is challenging, but some measures can be taken to reduce the risk of infection. These include:
* Avoiding exposure to fungal spores
* Practicing good wound care and hygiene
* Avoiding immunosuppressive medications whenever possible
* Monitoring for signs of infection and seeking medical attention promptly if symptoms develop
Overall, fusariosis is a severe and potentially life-threatening infection that requires prompt diagnosis and appropriate treatment. With early intervention and ongoing management, some patients may experience improved outcomes and quality of life.
Trichosporonosis can cause a range of symptoms depending on the site of infection. For example, skin lesions may appear as scaly, round patches that are red and itchy, while eye infections may lead to conjunctivitis with discharge and sensitivity to light. Nasal infections can cause nasal congestion, runny nose, and sinusitis.
Trichosporonosis is diagnosed through a combination of physical examination, medical history, and microbiological tests such as culture or polymerase chain reaction (PCR) to identify the presence of Trichosporon species in the affected tissue. Treatment typically involves antifungal medications, and the prognosis is generally good if the infection is treated promptly and effectively. However, in rare cases, trichosporonosis can be disseminated or resistant to treatment, which may lead to serious complications or death.
In summary, trichosporonosis is a type of fungal infection caused by Trichosporon species that can affect various parts of the body and can have a range of symptoms depending on the site of infection. It is important to seek medical attention if symptoms persist or worsen over time to receive proper diagnosis and treatment.
Tinea pedis can cause a range of symptoms, including:
* Itching, burning, and stinging sensations on the skin
* Redness, scaliness, and peeling of the skin
* Cracking and fissuring of the skin
* Blisters or sores that ooze fluid
* A bad odor emanating from the affected area
The fungus that causes tinea pedis can be contracted through direct contact with an infected person or by touching contaminated objects, such as shower floors, pool surfaces, or used towels. It can also be spread through shared footwear and socks.
To diagnose tinea pedis, a healthcare provider will typically examine the affected area and may take a skin scraping or nail clipping for further examination under a microscope or by culture. Treatment usually involves topical antifungal creams, ointments, or powders, as well as good hygiene practices such as washing and drying the feet thoroughly, especially after exercising or showering. In severe cases, oral antifungal medications may be prescribed.
Preventive measures to avoid getting tinea pedis include:
* Keeping the feet clean and dry
* Wearing well-ventilated shoes and socks made of breathable materials
* Avoiding sharing footwear or socks
* Using a separate towel for the feet
* Not walking barefoot in public areas
* Drying the feet thoroughly after showering or exercising
* Wearing socks that absorb sweat and change them frequently.
Also known as: Corneal inflammation, Eye inflammation, Keratoconjunctivitis, Ocular inflammation.
A type of meningitis caused by a fungal infection. Fungal meningitis is a serious and potentially life-threatening condition that can occur when fungi enter the bloodstream and spread to the membranes surrounding the brain and spinal cord (meninges).
The most common types of fungi that cause fungal meningitis are Aspergillus, Candida, and Cryptococcus. These fungi can be found in soil, decaying organic matter, and contaminated food. People with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive drugs, are at a higher risk of developing fungal meningitis.
Symptoms of fungal meningitis may include fever, headache, stiff neck, sensitivity to light, and confusion. If left untreated, fungal meningitis can lead to serious complications such as brain damage, hearing loss, and seizures. Treatment typically involves the use of antifungal medications, and in severe cases, surgery may be necessary to remove infected tissue or relieve pressure on the brain.
Preventive measures for fungal meningitis include avoiding exposure to fungal sources, practicing good hygiene, and taking antifungal medications as prescribed by a healthcare professional. Early diagnosis and treatment are critical in preventing serious complications and improving outcomes for patients with fungal meningitis.
Symptoms of neutropenia may include recurring infections, fever, fatigue, weight loss, and swollen lymph nodes. The diagnosis is typically made through a blood test that measures the number of neutrophils in the blood.
Treatment options for neutropenia depend on the underlying cause but may include antibiotics, supportive care to manage symptoms, and in severe cases, bone marrow transplantation or granulocyte-colony stimulating factor (G-CSF) therapy to increase neutrophil production.
The main cause of ABPA is exposure to airborne spores of the fungus Aspergillus, which are commonly found in soil and decaying organic matter. Individuals with a pre-existing allergic condition may be more susceptible to developing an allergic reaction to these spores, leading to inflammation and damage to the airways.
Diagnosis of ABPA typically involves a combination of physical examination, medical history, and diagnostic tests such as chest X-rays, CT scans, and bronchoscopy with biopsy. Treatment for ABPA typically involves corticosteroids to reduce inflammation and antifungal medications to treat any underlying infection. In severe cases, hospitalization may be necessary to provide oxygen therapy and other supportive care.
Prevention of ABPA includes avoiding exposure to known allergens and maintaining good respiratory hygiene. This can involve regularly cleaning and disinfecting surfaces and objects, using HEPA filters in air purifiers, and wearing a mask when working with or around potentially contaminated materials.
Prognosis for ABPA is generally good if treated promptly and effectively, but untreated cases can lead to serious complications such as respiratory failure and other organ damage. With proper management and prevention strategies in place, individuals with ABPA can lead active and fulfilling lives.
Pulmonary aspergillosis is a type of fungal infection that affects the lungs and is caused by the fungus Aspergillus. It can occur in people with weakened immune systems, such as those with cancer, HIV/AIDS, or taking immunosuppressive drugs following an organ transplant.
The symptoms of pulmonary aspergillosis can vary depending on the severity of the infection and may include:
* Coughing up blood or mucus
* Chest pain or tightness
* Fever
* Shortness of breath
* Chills
* Weight loss
In severe cases, pulmonary aspergillosis can lead to respiratory failure, which can be life-threatening.
Pulmonary aspergillosis is diagnosed through a combination of imaging tests such as chest X-rays, CT scans, and fungal cultures. Treatment typically involves antifungal medications and supportive care to manage symptoms and prevent complications. In severe cases, hospitalization may be necessary to provide oxygen therapy and other respiratory support.
Prevention is key in avoiding pulmonary aspergillosis, especially for individuals with weakened immune systems. This includes avoiding exposure to fungal spores, managing underlying health conditions, and taking antifungal medications as prescribed. Early diagnosis and treatment can significantly improve outcomes for those affected by this condition.
Symptoms of otitis externa may include:
* Ear pain or tenderness
* Redness and swelling of the ear canal
* Discharge or pus in the ear canal
* Itching or burning sensation in the ear canal
* Fever or chills
* Difficulty hearing or feeling as if the ear is clogged
Otitis externa can be diagnosed by a healthcare professional through a physical examination of the ear canal and may also involve a pus sample or imaging tests such as X-rays or CT scans to rule out other conditions. Treatment options for otitis externa may include antibiotics, anti-inflammatory medications, or topical creams or drops to reduce pain and inflammation. In severe cases, surgery may be necessary to remove any infected tissue or debris from the ear canal.
Prevention of otitis externa includes avoiding exposure to moisture, using earplugs when swimming or showering, and keeping the ears clean and dry. If you suspect you have otitis externa, it is important to seek medical attention promptly to prevent complications such as mastoiditis or meningitis.
1. Zygomycosis is a rare and opportunistic fungal infection caused by members of the order Ophiostomatales, which primarily affects the skin and subcutaneous tissues, but can also disseminate to other organs and cause severe systemic disease.
2. Zygomycosis is a type of deep mycosis that is characterized by the presence of broad, flat pseudohyphae and/or thick-walled spherules in the infected tissue, typically seen on histopathological examination.
3. Zygomycosis is an invasive fungal infection that can affect various parts of the body, including the skin, soft tissues, bones, and organs, and is often associated with underlying conditions such as diabetes, immunodeficiency, or malignancy.
4. Zygomycosis is a rare and aggressive fungal infection that can cause significant morbidity and mortality if left untreated, and early diagnosis and treatment are essential to prevent progression of the disease.
Examples of AROIs include:
1. Pneumocystis pneumonia (PCP): a type of pneumonia caused by the fungus Pneumocystis jirovecii.
2. Tuberculosis (TB): a bacterial infection that can affect the lungs, brain, or other organs.
3. Toxoplasmosis: an infection caused by the parasite Toxoplasma gondii that can affect the brain, eyes, and other organs.
4. Cryptococcosis: a fungal infection that can affect the lungs, brain, or skin.
5. Histoplasmosis: a fungal infection caused by Histoplasma capsulatum that can affect the lungs, skin, and other organs.
6. Aspergillosis: a fungal infection caused by Aspergillus species that can affect the lungs, sinuses, and other organs.
7. Candidiasis: a fungal infection caused by Candida species that can affect the mouth, throat, vagina, or skin.
8. Kaposi's sarcoma: a type of cancer that is caused by the human herpesvirus 8 (HHV-8) and can affect the skin and lymph nodes.
9. Wasting syndrome: a condition characterized by weight loss, fatigue, and diarrhea.
10. Opportunistic infections that can affect the gastrointestinal tract, such as cryptosporidiosis and isosporiasis.
AROIs are a major cause of morbidity and mortality in individuals with HIV/AIDS, and they can be prevented or treated with antimicrobial therapy, supportive care, and other interventions.
The symptoms of coccidioidomycosis can vary depending on the severity of the infection and the individual's immune response. Some people may experience mild symptoms, such as fever, cough, and fatigue, while others may develop more severe symptoms, including pneumonia, meningitis, and bone or skin infections. Skin lesions and rashes are also common.
Diagnosis of coccidioidomycosis typically involves a combination of physical examination, laboratory tests, and imaging studies. Treatment may involve antifungal medications and supportive care to manage symptoms. In severe cases, hospitalization may be necessary.
Prevention is key in avoiding coccidioidomycosis, which includes avoiding areas with high concentrations of the fungus, using respiratory protection when working in areas where the fungus is present, and taking antifungal medications prophylactically for those who are at high risk.
Prognosis for coccidioidomycosis is generally good for those with mild infections, but can be poor for those with severe infections or underlying conditions such as HIV/AIDS or cancer. Long-term effects of the infection can include lung scarring and joint damage.
Antifungal
Ketoconazole
Fungal infection
Topical antifungal drugs
Ionophore
Sudocrem
Neil A. R. Gow
Polylysine
Frank Odds
Ethonam
Infectious diseases (medical specialty)
Pessary
Ibrexafungerp
Naftifine
Terconazole
Aspergillus alabamensis
Echinocandin
Fenpropimorph
Posaconazole
Baldwin's rules
Sirolimus
Polyene antimycotic
Pickling
Penicillium restrictum
Protoanemonin
Isavuconazonium
Cystathionine beta-lyase
Geomyces pannorum
Candida tropicalis
1,2,4-Triazole
Bohemic acid
2,4-Dichlorophenol
Candida blankii
Flacourtia inermis
Orotomide
Febrile neutropenia
Interferon
Saksenaea vasiformis
Streptomyces natalensis
Cunninghamella echinulata
Oudemansiella canarii
Anemopsis
Microsporum canis
Cyproconazole
Antimicrobial
Benzyl cinnamate
Voriconazole
Pattern recognition receptor
Pathogenic fungus
Thymol
Polyene
Mycotoxin
Debregeasia saeneb
Sparassol
Vaccine hesitancy
Mycotypha microspora
E-6 process
Stigmatella aurantiaca
Sporotrichosis Medication: Antifungal agents
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Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners. | J...
Antifungal activity of Lavandula angustifolia essential oil against Candida albicans yeast and mycelial form
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Candida5
- This study was carried out from October 2003 to March 2007 to investigate susceptibility patterns to antifungals of Candida strains isolated from 410 immunocompromised patients in Shiraz, Islamic Republic of Iran. (who.int)
- To investigate the ultimate tensile strength of temporary soft denture liners modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm (SC5314) determined in previous microbiological research . (bvsalud.org)
- Anidulafungin is an antifungal agent of the echinocandin class which is highly active in vitro against fluconazole resistant Candida species. (clinicaltrials.gov)
- Also in this issue, a novel agent of fungemia, Candida auris , is reported as having been detected in India. (cdc.gov)
- resistant to the antifungal agent fluconazole, which is concerning because fluconazole is frequently the first-line treatment for invasive Candida species infections in many countries. (cdc.gov)
Azole antifungal agents1
- Risk factors such as changes in land use, seasonal migration, international travel, extreme weather, and natural disasters, and the use of azole antifungal agents in large-scale agriculture are believed to underlay many of the increases in community-acquired fungal infections. (cdc.gov)
Antibacterial5
- This communication presents the synthesis, docking, and antibacterial and antifungal evaluation of nitro chalcones. (rjptonline.org)
- All the synthesized derivatives had good antifungal potency in comparison to the antibacterial potency. (rjptonline.org)
- It is known to have antibacterial and antifungal properties. (medicalnewstoday.com)
- Triclosan has had widespread use in the general population as an antibacterial and antifungal agent and is commonly found in consumer products such as soaps, deodorants, toothpastes, shaving creams, mouth washes, and cleaning supplies. (cdc.gov)
- If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. (drugs.com)
Triazole1
- A synthetic triazole antifungal agent that inhibits fungal cell growth by inhibiting the cytochrome P-450-dependent synthesis of ergosterol, a vital component of fungal cell membranes. (medscape.com)
Inhibits fungal1
- Synthetic PO antifungal (broad-spectrum bistriazole) that selectively inhibits fungal cytochrome P-450 and sterol C-14 alpha-demethylation. (medscape.com)
Appropriate antifungal1
- Patients who test positive for blood cryptococcal antigen are screened for meningitis (LP) and prescribed appropriate antifungal medicines 4. (slideshare.net)
Amphotericin5
- Antifungal activity of amphotericin B results from its ability to insert itself into fungal cytoplasmic membrane at sites that contain ergosterol or other sterols. (medscape.com)
- This study is intended to offer patients with FRMC an alternate therapy with amphotericin B or with other agents whose efficacy and/or safety are inadequate in the treatment of this disease. (clinicaltrials.gov)
- type is the antifungal agent amphotericin B, which binds to a specific molecule (ergosterol) found in fungal cells. (britannica.com)
- local injection of the antibiotic amphotericin B. Extensive disease may require long-term therapy with an oral antifungal drug. (britannica.com)
- is with the antifungal drugs amphotericin B and flucytosine. (britannica.com)
Isolates1
- Susceptibility of the isolates to antifungal agents was determined using the reference broth microdilution method. (who.int)
Vitro1
- Chloroform, ethanolic, methanolic, ethyl acetate and aqueous root extracts of Anogeissus leiocarpus and Ter- minalia avicennioides were investigated in vitro for antifungal activities against Aspergillus niger, Aspergillus fumigatus, Penicillium species, Microsporum audouinii and Trichophyton rubrum using radial growth technique. (who.int)
Strains1
- Compounds 10 and 12 were found to be the most potent analogues of the series against all the tested antifungal strains. (rjptonline.org)
Mechanism1
- These agents have a mechanism of action that may involve an alteration of RNA and DNA metabolism. (medscape.com)
Broad-spectrum1
- Treatment should involve broad-spectrum antifungal medications that have adequate central nervous system penetration. (cdc.gov)
Patients5
- Regular investigations into antifungal resistance in medical centres is highly recommended as this will result in more efficient management of invasive candidiasis in immunocompromised patients. (who.int)
- Des analyses régulières de la résistance aux antifongiques dans les centres médicaux sont fortement recommandées, car les résultats permettront une prise en charge plus efficace de la candidose systémique chez les patients immunodéprimés. (who.int)
- Survival rates of non-HIV-infected patients who are treated with these agents usually is very high. (britannica.com)
- To assess the number of Streptococcus mutans in saliva of patients with denture stomatitis before and after antifungal therapy. (bvsalud.org)
- The use of oral antimicrobial agents may provide a beneficial effect for denture stomatitis patients that are under antifungal therapy and that have poor oral hygiene and unfavorable salivary parameters. (bvsalud.org)
Antimicrobial1
- Shiradkar M. Design and synthesis of some novel chalcones as potent antimicrobial agent. (rjptonline.org)
Substances1
- Confocal laser scanning microscopy was done by applying FUN-1 stain to screen the role of the agents on extracellular polymeric substances. (westminster.ac.uk)
Yeasts2
- Gradient diffusion strips (sometimes referred to by the trade name Etest™) are an accurate, inexpensive methodology for testing yeasts for antifungal susceptibility. (cdc.gov)
- Gram-negative organisms, herpes simplex virus, dermatophytes and yeasts have also been reported as causative agents. (aafp.org)
Fungi1
- Another study found that tea tree oil was more effective at killing fungi than several other antifungal agents that were tested. (medicalnewstoday.com)
Topical2
- Treatment options include the use of topical antifungal agents and steroids, and surgical intervention. (aafp.org)
- Other topical or oral antifungal agents are preferred over sulfanilamide for uncomplicated vulvovaginitis candidiasis . (medicinenet.com)
Cutaneous1
- The orally available azole antifungals are the drugs of choice for cutaneous or lymphocutaneous sporotrichosis in developed nations. (medscape.com)
Treatment1
- Treatment with antifungal agents has not been proven to prevent dissemination. (cdc.gov)
Activity2
- The antifungal activity of the essential oil of Lavandula angustifolia Mill. (nih.gov)
- their synthesis by microwave irradiation and antifungal activity. (rjptonline.org)
Causative1
- Use antivirals if the causative agent is suspected to be viral such as in cases associated with herpes zoster or shingles. (medscape.com)
Infections2
- Many of these reports describe infections caused by new agents, as well as by traditional agents with new virulence factors or new mechanisms of infection. (cdc.gov)
- and immunomodulatory agents for treating underlying diseases from cancer to rheumatoid arthritishas contributed to the increase in fungal infections in immunocompromised hosts. (cdc.gov)
Effective1
- A report in the Ulster Medical Journal , which found that garlic has effective antifungal properties. (medicalnewstoday.com)
Investigate1
- During World War I, the AUES was established to investigate testing, production and effects of chemical warfare agents, antidotes and protective equipment. (cdc.gov)
Candidiasis1
- Antifungals are indicated if the source is caused by a fungus (eg, oral thrush/candidiasis). (medscape.com)
Oral3
- 3 If infection persists, warm soaks in addition to an oral antistaphylococcal agent and splint protection of the affected part are indicated. (aafp.org)
- Tomar boro por vía oral en dosis más altas posiblemente no sea seguro y se ha relacionado con un menor peso al nacer y defectos congénitos. (medlineplus.gov)
- Es posible que el boro no sea seguro cuando se toma por vía oral en dosis más altas. (medlineplus.gov)
Study2
- To study the agents' effect on the conidial viability, flow cytometry analysis was performed. (westminster.ac.uk)
- The objective of this study was to assay the glycosides, saponins, tannins and polyphenols which root extracts of Anogeissus leiocarpus and Terminalia are the bioactive bases responsible for the antimicro- avicennioides for their antifungal activities. (who.int)
Term1
- Also, be interested to obtain to those ia when outlining your buy Hydroxy Pyridones as Antifungal or media received term. (higiaz.com.ar)
Effect1
- Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners. (bvsalud.org)
Products1
- The sampling plan was designed to collect a broad range of volatile and semivolatile chemicals including petroleum hydrocarbons, chlorinated hydrocarbons, potential explosive degradation products and potential chemical warfare agent degradation products. (cdc.gov)