Bee Venoms: Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.Antifibrinolytic Agents: Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.Apitherapy: The medical use of honey bee products such as BEE VENOM; HONEY; bee pollen; PROPOLIS; and royal jelly.Melitten: Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.Baculoviridae: Family of INSECT VIRUSES containing two subfamilies: Eubaculovirinae (occluded baculoviruses) and Nudibaculovirinae (nonoccluded baculoviruses). The Eubaculovirinae, which contain polyhedron-shaped inclusion bodies, have two genera: NUCLEOPOLYHEDROVIRUS and GRANULOVIRUS. Baculovirus vectors are used for expression of foreign genes in insects.Fibrin: A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.Fibrin Fibrinogen Degradation Products: Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.Pancreatic Elastase: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.Bees: Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.Spodoptera: A genus of owlet moths of the family Noctuidae. These insects are used in molecular biology studies during all stages of their life cycle.Nonprescription Drugs: Medicines that can be sold legally without a DRUG PRESCRIPTION.Drug Information Services: Services providing pharmaceutic and therapeutic drug information and consultation.Self Medication: The self administration of medication not prescribed by a physician or in a manner not directed by a physician.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Syringes: Instruments used for injecting or withdrawing fluids. (Stedman, 25th ed)BooksPrescription Drugs: Drugs that cannot be sold legally without a prescription.Community Pharmacy Services: Total pharmaceutical services provided to the public through community pharmacies.Drug Prescriptions: Directions written for the obtaining and use of DRUGS.Medical Waste Disposal: Management, removal, and elimination of biologic, infectious, pathologic, and dental waste. The concept includes blood, mucus, tissue removed at surgery or autopsy, soiled surgical dressings, and other materials requiring special control and handling. Disposal may take place where the waste is generated or elsewhere.Aminocaproic Acid: An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.Aprotinin: A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)Disseminated Intravascular Coagulation: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.Aminocaproates: Amino derivatives of caproic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the amino caproic acid structure.Blood Loss, Surgical: Loss of blood during a surgical procedure.Carboxypeptidase U: A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active peptides and proteins thereby regulating their activity. It is a zinc enzyme with no preference shown for lysine over arginine. Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.Fibrinolysis: The natural enzymatic dissolution of FIBRIN.Hemorrhage: Bleeding or escape of blood from a vessel.Hemophilia A: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.Hemarthrosis: Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.Hemophilia B: A deficiency of blood coagulation factor IX inherited as an X-linked disorder. (Also known as Christmas Disease, after the first patient studied in detail, not the holy day.) Historical and clinical features resemble those in classic hemophilia (HEMOPHILIA A), but patients present with fewer symptoms. Severity of bleeding is usually similar in members of a single family. Many patients are asymptomatic until the hemostatic system is stressed by surgery or trauma. Treatment is similar to that for hemophilia A. (From Cecil Textbook of Medicine, 19th ed, p1008)Marketing: Activity involved in transfer of goods from producer to consumer or in the exchange of services.New Orleans: City in Orleans Parish (county), largest city in state of LOUISIANA. It is located between the Mississippi River and Lake Pontchartrain.Research Report: Detailed account or statement or formal record of data resulting from empirical inquiry.Floods: Sudden onset water phenomena with different speed of occurrence. These include flash floods, seasonal river floods, and coastal floods, associated with CYCLONIC STORMS; TIDALWAVES; and storm surges.Beekeeping: The management and maintenance of colonies of honeybees.Cyclonic Storms: Non-frontal low-pressure systems over tropical or sub-tropical waters with organized convection and definite pattern of surface wind circulation.Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.Hemangioendothelioma: A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)Neoplasms, Vascular Tissue: Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.Vascular Neoplasms: Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.Hemangioma: A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)Hemangiosarcoma: A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed)Hemangioendothelioma, Epithelioid: A tumor of medium-to-large veins, composed of plump-to-spindled endothelial cells that bulge into vascular spaces in a tombstone-like fashion. These tumors are thought to have "borderline" aggression, where one-third develop local recurrences, but only rarely metastasize. It is unclear whether the epithelioid hemangioendothelioma is truly neoplastic or an exuberant tissue reaction, nor is it clear if this is equivalent to Kimura's disease (see ANGIOLYMPHOID HYPERPLASIA WITH EOSINOPHILIA). (Segen, Dictionary of Modern Medicine, 1992)Hemangioma, Capillary: A dull red, firm, dome-shaped hemangioma, sharply demarcated from surrounding skin, usually located on the head and neck, which grows rapidly and generally undergoes regression and involution without scarring. It is caused by proliferation of immature capillary vessels in active stroma, and is usually present at birth or occurs within the first two or three months of life. (Dorland, 27th ed)Vascular Malformations: A spectrum of congenital, inherited, or acquired abnormalities in BLOOD VESSELS that can adversely affect the normal blood flow in ARTERIES or VEINS. Most are congenital defects such as abnormal communications between blood vessels (fistula), shunting of arterial blood directly into veins bypassing the CAPILLARIES (arteriovenous malformations), formation of large dilated blood blood-filled vessels (cavernous angioma), and swollen capillaries (capillary telangiectases). In rare cases, vascular malformations can result from trauma or diseases.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Rare Diseases: A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.Price ListsTablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Postoperative Hemorrhage: Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Hemostasis, Surgical: Control of bleeding during or after surgery.

Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women. (1/402)

Plasmin-alpha2-antiplasmin complex (PAP) marks plasmin generation and fibrinolytic balance. We recently observed that elevated levels of PAP predict acute myocardial infarction in the elderly, yet little is known about the correlates of PAP. We measured PAP in 800 elderly subjects who were free of clinical cardiovascular disease in 2 cohort studies: the Cardiovascular Health Study and the Honolulu Heart Program. Median PAP levels did not differ between the Cardiovascular Health Study (6.05+/-1.46 nmol/L) and the Honolulu Heart Program (6.11+/-1.44 nmol/L), and correlates of PAP were similar in both cohorts. In CHS, PAP levels increased with age (r=0. 30), procoagulant factors (eg, factor VIIc, r=0.15), thrombin activity (prothrombin fragment F1+2, r=0.29), and inflammation-sensitive proteins (eg, fibrinogen, r=0.44; factor VIIIc, r=0.37). PAP was associated with increased atherosclerosis as measured by the ankle-arm index (AAI) (P for trend, +info)

Usefulness of D-dimer, blood gas, and respiratory rate measurements for excluding pulmonary embolism. (2/402)

BACKGROUND: A study was undertaken to assess the usefulness of the SimpliRED D-dimer test, arterial oxygen tension, and respiratory rate measurement for excluding pulmonary embolism (PE) and venous thromboembolism (VTE). METHODS: Lung scans were performed in 517 consecutive medical inpatients with suspected acute PE over a one year period. Predetermined end points for objectively diagnosed PE in order of precedence were (1) a post mortem diagnosis, (2) a positive pulmonary angiogram, (3) a high probability ventilation perfusion lung scan when the pretest probability was also high, and (4) the unanimous opinion of an adjudication committee. Deep vein thrombosis (DVT) was diagnosed by standard ultrasound and venography. RESULTS: A total of 40 cases of PE and 37 cases of DVT were objectively diagnosed. The predictive value of a negative SimpliRED test for excluding objectively diagnosed PE was 0.99 (error rate 2/249), that of PaO2 of > or = 80 mm Hg (10.7 kPa) was 0.97 (error rate 5/160), and that of a respiratory rate of < or = 20/min was 0.95 (error rate 14/308). The best combination of findings for excluding PE was a negative SimpliRED test and PaO2 > or = 80 mm Hg, which gave a predictive value of 1.0 (error rate 0/93). The predictive value of a negative SimpliRED test for excluding VTE was 0.98 (error rate 5/249). CONCLUSIONS: All three of these observations are helpful in excluding PE. When any two parameters were normal, PE was very unlikely. In patients with a negative SimpliRED test and PaO2 of > or = 80 mm Hg a lung scan is usually unnecessary. Application of this approach for triage in the preliminary assessment of suspected PE could lead to a reduced rate of false positive diagnoses and considerable resource savings.  (+info)

Tranexamic acid increases peritoneal ultrafiltration volume in patients on CAPD. (3/402)

OBJECTIVE: The preservation of ultrafiltration (UF) capacity is crucial to maintaining long-term continuous ambulatory peritoneal dialysis (CAPD).The aim of the present study was to investigate whether the antiplasmin agent tranexamic acid (TNA) increases UF volume in CAPD patients. PATIENTS AND METHODS: Fifteen patients on CAPD, 5 with UF loss and 10 without UF loss, were recruited for the study. The effect of TNA was evaluated with respect to changes in UF volume, peritoneal permeability, peritoneal clearance, bradykinin (BK), and tissue plasminogen activator (tPA) concentration. SETTING: Dialysis unit of the Saiseikai Central Hospital. RESULTS: In patients with UF loss, 2 weeks of treatment with oral TNA produced a significant increase in UF volume in all subjects (5/5).TNA also produced a significant increase in peritoneal clearances of urea and creatinine (Cr). However, the peritoneal equilibration test (PET) revealed that TNA had no effect on dialysate/plasma (D/P) Cr, Kt/V, or the protein catabolic rate (PCR).TNA also had no effect on net glucose reabsorption. In contrast, significant decreases in BK and blood tPA concentrations in response to TNA treatment were noted. BK concentration in drainage fluid was also reduced. In the case of patients without UF loss,TNA produced an increase in UF volume in 70% (7/10). However, no differences were found in blood and drainage BK and tPA concentrations between theTNA treatment and nontreatment periods in these patients. A comparison of basal BK and tPA concentration showed that there were no differences in these parameters between patients with UF loss and those without loss of UF. Furthermore,TNA given intraperitoneally to a patient also produced a marked increase in UF volume. CONCLUSION: The present study suggests thatTNA enhances UF volume in patients both with and without UF loss. SinceTNA did not affect peritoneal permeability and glucose reabsorption, the mechanism by which TNA exerts an enhancing action on UF is largely unknown. We speculate that it may be associated with suppression of the BK and/or tPA system, at least in patients with UF loss.  (+info)

Randomised controlled trial of educational package on management of menorrhagia in primary care: the Anglia menorrhagia education study. (4/402)

OBJECTIVE: To determine whether an educational package could influence the management of menorrhagia, increase the appropriateness of choice of non-hormonal treatment, and reduce referral rates from primary to secondary care. DESIGN: Randomised controlled trial. SETTING: General practices in East Anglia. SUBJECTS: 100 practices (348 doctors) in primary care were recruited and randomised to intervention (54) and control (46). INTERVENTIONS: An educational package based on principles of "academic detailing" with independent academics was given in small practice based interactive groups with a visual presentation, a printed evidence based summary, a graphic management flow chart, and a follow up meeting at 6 months. OUTCOME MEASURES: All practices recorded consultation details, treatments offered, and outcomes for women with regular heavy menstrual loss (menorrhagia) over 1 year. RESULTS: 1001 consultation data sheets for menorrhagia were returned. There were significantly fewer referrals (20% v 29%; odds ratio 0. 64; 95% confidence interval 0.41 to 0.99) and a significantly higher use of tranexamic acid (odds ratio 2.38; 1.61 to 3.49) in the intervention group but no overall difference in norethisterone treatment compared with controls. There were more referrals when tranexamic acid was given with norethisterone than when it was given alone. Those practices reporting fewer than 10 cases showed the highest increase in prescribing of tranexamic acid. CONCLUSIONS: The educational package positively influenced referral for menorrhagia and treatment with appropriate non-hormonal drugs.  (+info)

Pharmacokinetics of epsilon-aminocaproic acid in patients undergoing aortocoronary bypass surgery. (5/402)

BACKGROUND: Epsilon-aminocaproic acid (EACA) is commonly infused during cardiac surgery using empiric dosing schemes. The authors developed a pharmacokinetic model for EACA elimination in surgical patients, tested whether adjustments for cardiopulmonary bypass (CPB) would improve the model, and then used the model to develop an EACA dosing schedule that would yield nearly constant EACA blood concentrations. METHODS: Consenting patients undergoing elective coronary artery surgery received one of two loading doses of EACA, 30 mg/kg (group I, n = 7) or 100 mg/kg (group II, n = 6) after CPB, or (group III) a 100 mg/kg loading dose before CPB and a 10 mg x kg(-1) x h(-1) maintenance infusion continued for 4 h during and after CPB (n = 7). Two patients with renal failure received EACA in the manner of group III. Blood concentrations of EACA, measured by high-performance liquid chromatography, were subjected to mixed-effects pharmacokinetic modeling. RESULTS: The EACA concentration data were best fit by a model with two compartments and corrections for CPB. The elimination rate constant k10 fell from 0.011 before CPB to 0.0006 during CPB, returning to 0.011 after CPB. V1 increased 3.8 l with CPB and remained at that value thereafter. Cl1 varied from 0.08 l/min before CPB to 0.007 l/min during CPB and 0.13 l/min after CPB. Cl2 increased from 0.09 l/min before CPB to 0.14 l/min during and after CPB. Two patients with renal failure demonstrated markedly reduced clearance. Using their model, the authors predict that an EACA loading infusion of 50 mg/kg given over 20 min and a maintenance infusion of 25 mg x kg(-1) x h(-1) would maintain a nearly constant target concentration of 260 microg/ml. CONCLUSIONS: EACA clearance declines and volume of distribution increases during CPB. The authors' model predicts that more stable perioperative EACA concentrations would be obtained with a smaller loading dose (50 mg/kg given over 20 min) and a more rapid maintenance infusion (25 mg x kg(-1) x h(-1)) than are typically employed.  (+info)

The effect of prophylactic epsilon-aminocaproic acid on bleeding, transfusions, platelet function, and fibrinolysis during coronary artery bypass grafting. (6/402)

BACKGROUND: Antifibrinolytic medications administered before skin incision decrease bleeding after cardiac surgery. Numerous case reports indicate thrombus formation with administration of epsilon-aminocaproic acid (epsilon-ACA). The purpose of this study was to examine the efficacy of epsilon-ACA administered after heparinization but before cardiopulmonary bypass in reducing bleeding and transfusion requirements after primary coronary artery bypass surgery. METHODS: Seventy-four adult patients undergoing primary coronary artery bypass surgery were randomized to receive 125 mg/kg epsilon-ACA followed by an infusion of 12.5 mg x kg(-1) x h(-1) or an equivalent volume of saline. Coagulation studies, thromboelastography, and platelet aggregation tests were performed preoperatively, after bypass, and on the first postoperative day. Mediastinal drainage was recorded during the 24 h after surgery. Homologous blood transfusion triggers were predefined and transfusion amounts were recorded. RESULTS: One patient was excluded for surgical bleeding and five patients were excluded for transfusion against predefined criteria One patient died from a dysrhythmia 2 h postoperatively. Among the remaining 67, the epsilon-ACA group had less mediastinal blood loss during the 24 h after surgery, 529+/-241 ml versus 691+/-286 ml (mean +/- SD), P < 0.05, despite longer cardiopulmonary bypass times and lower platelet counts, P < 0.05. Platelet aggregation was reduced in both groups following cardiopulmonary bypass but did not differ between groups. Homologous blood transfusion was similar between both groups. CONCLUSIONS: Prophylactic administration of epsilon-ACA after heparinization but before cardiopulmonary bypass is of minimal benefit for reducing blood loss postoperatively in patients undergoing primary coronary artery bypass grafting.  (+info)

The effects of hydrostatic pressure on the conformation of plasminogen. (7/402)

Plasminogen undergoes a large conformational change when it binds 6-aminohexanoate. Using ultraviolet absorption spectroscopy and native PAGE, we show that hydrostatic pressure brings about the same conformational change. The volume change for this conformational change is -33 mL.mol-1. Binding of ligand and hydrostatic pressure both cause the protein to open up to expose surfaces that had previously been buried in the interior.  (+info)

Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. (8/402)

BACKGROUND: Although improved epicardial blood flow (as assessed with either TIMI flow grades or TIMI frame count) has been related to reduced mortality after administration of thrombolytic drugs, the relationship of myocardial perfusion (as assessed on the coronary arteriogram) to mortality has not been examined. METHODS AND RESULTS: A new, simple angiographic method, the TIMI myocardial perfusion (TMP) grade, was used to assess the filling and clearance of contrast in the myocardium in 762 patients in the TIMI (Thrombolysis In Myocardial Infarction) 10B trial, and its relationship to mortality was examined. TMP grade 0 was defined as no apparent tissue-level perfusion (no ground-glass appearance of blush or opacification of the myocardium) in the distribution of the culprit artery; TMP grade 1 indicates presence of myocardial blush but no clearance from the microvasculature (blush or a stain was present on the next injection); TMP grade 2 blush clears slowly (blush is strongly persistent and diminishes minimally or not at all during 3 cardiac cycles of the washout phase); and TMP grade 3 indicates that blush begins to clear during washout (blush is minimally persistent after 3 cardiac cycles of washout). There was a mortality gradient across the TMP grades, with mortality lowest in those patients with TMP grade 3 (2.0%), intermediate in TMP grade 2 (4.4%), and highest in TMP grades 0 and 1 (6.0%; 3-way P=0.05). Even among patients with TIMI grade 3 flow in the epicardial artery, the TMP grades allowed further risk stratification of 30-day mortality: 0.73% for TMP grade 3; 2.9% for TMP grade 2; 5.0% for TMP grade 0 or 1 (P=0.03 for TMP grade 3 versus grades 0, 1, and 2; 3-way P=0.066). TMP grade 3 flow was a multivariate correlate of 30-day mortality (OR 0.35, 95% CI 0.12 to 1.02, P=0.054) in a multivariate model that adjusted for the presence of TIMI 3 flow (P=NS), the corrected TIMI frame count (OR 1.02, P=0.06), the presence of an anterior myocardial infarction (OR 2.3, P=0.03), pulse rate on admission (P=NS), female sex (P=NS), and age (OR 1.1, P<0.001). CONCLUSIONS: Impaired perfusion of the myocardium on coronary arteriography by use of the TMP grade is related to a higher risk of mortality after administration of thrombolytic drugs that is independent of flow in the epicardial artery. Patients with both normal epicardial flow (TIMI grade 3 flow) and normal tissue level perfusion (TMP grade 3) have an extremely low risk of mortality.  (+info)

*Tranexamic acid

In melasma - tranexamic acid is sometimes used in skin whitening as a topical agent, injected into a lesion, or taken by mouth ... Ker K, Roberts I, Shakur H, Coats TJ (May 2015). "Antifibrinolytic drugs for acute traumatic injury". The Cochrane Database of ... Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, Fergusson DA, Ker K (January 2011). "Anti-fibrinolytic use for ... It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen or plasmin. This ...

*Aprotinin

The study authors recommend older antifibrinolytics (such as tranexamic acid) in which these risks were not documented. The ... Mahdy AM, Webster NR (2004). "Perioperative systemic haemostatic agents". British journal of anaesthesia. 93 (6): 842-58. doi: ... On October 25, 2007, the FDA issued a statement regarding the "Blood conservation using antifibrinolytics" (BART) randomized ... The preliminary findings suggest that, compared to other antifibrinolytic drugs (epsilon-aminocaproic acid and tranexamic acid ...

*Fibrinolysin

Additionally, combinations with the antifibrinolytic agent tranexamic acid have been withdrawn from pharmaceutic markets. ...

*Alveolar osteitis

There is also evidence that antifibrinolytic agents applied to the socket after the extraction may reduce the risk of dry ...

*Von Willebrand disease

The antifibrinolytic agents epsilon amino caproic acid and tranexamic acid are useful adjuncts in the management of vWD ...

*List of MeSH codes (D16)

... fibrin modulating agents MeSH D27.505.519.421.500 --- antifibrinolytic agents MeSH D27.505.519.421.750 --- fibrinolytic agents ... antifibrinolytic agents MeSH D27.505.954.502.270.546 --- heparin antagonists MeSH D27.505.954.502.427 --- fibrinolytic agents ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ...

*Pamba

... a protease inhibitor and antifibrinolytic agent Bryan Pamba (born 1992), French basketball player Saleh Pamba (born 1950), ...

*Menorrhagia

First line Intrauterine device with progesterone Second Line Tranexamic acid an antifibrinolytic agent Nonsteroidal anti- ...

*Utako Okamoto

During her lifetime she was unable to persuade obstetricians at Kobe to trial the antifibrinolytic agent, which had become a ... The Okamotos found it was 27 times as powerful and thus a promising hemostatic agent and published their findings in the Keio ... Also in 2010, the WOMAN (World Maternal Antifibrinolytic) trial began, a randomised, double-blind, placebo-controlled study of ... Paul Carless (25 November 2008). "PROPOSAL FOR THE INCLUSION OF TRANEXAMIC ACID (ANTI-FIBRINOLYTIC - LYSINE ANALOGUE) IN THE ...

*Antifibrinolytic

Fibrinolytic agents "antifibrinolytic" at Dorland's Medical Dictionary The CRASH-2 Collaborators (2010). "Effects of tranexamic ... Antifibrinolytics, such as aminocaproic acid (ε-aminocaproic acid) and tranexamic acid are used as inhibitors of fibrinolysis. ... The antifibrinolytic drug aprotinin was abandoned after identification of major side effects, especially on the kidney.[ ... In 2010, the CRASH-2 trial showed that the antifibrinolytic drug tranexamic acid safely reduces mortality in bleeding trauma ...

*Fibrinolysis

Antifibrinolytics, such as aminocaproic acid (ε-aminocaproic acid) and tranexamic acid are used as inhibitors of fibrinolysis. ... Tissue plasminogen activator (t-PA) and urokinase are the agents that convert plasminogen to the active plasmin, thus allowing ... The antifibrinolytic drug aprotinin was abandoned after identification of major side effects, especially on kidney. Nattokinase ... Thrombolysis refers to the dissolution of the thrombus due to various agents while fibrinolysis refers specifically to the ...

*Angioedema

These agents increase the level of aminopeptidase P, an enzyme that inactivates kinins; kinins (especially bradykinin) are ... In acquired angioedema, HAE types I and II, and nonhistaminergic angioedema, antifibrinolytics such as tranexamic acid or ε- ... The version related to histamine is to due an allergic reaction to agents such as insect bites, foods, or medications. The ...

*Pharmaceutical drug

In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... antifibrinolytics, Hormone Replacement Therapy (HRT), bone regulators, beta-receptor agonists, follicle stimulating hormone, ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ... hypolipidaemic agents. Drugs affecting the central nervous system include: Psychedelics, hypnotics, anaesthetics, ...

*Glanzmann's thrombasthenia

Dental hygiene lessens gingival bleeding Avoidance of antiplatelet agents such as aspirin and other anti-inflammatory drugs ( ... supplementation may be necessary if excessive or prolonged bleeding has caused anemia Hepatitis B vaccine Antifibrinolytic ... a model disease which paved the way to powerful therapeutic agents". Pathophysiology of Haemostasis and Thrombosis. 32 (5-6): ... a class of powerful antiplatelet agents. Therapy involves both preventive measures and treatment of specific bleeding episodes ...

*Thromboelastometry

Whole blood TEM is sensitive to haemostasis affecting agents such as plasma expanders or acidosis while the effects of these ... Therefore, the test helps in identifying the necessity of administrating antifibrinolytic drugs. Furthermore, APTEM enables the ... hemostyptic and antifibrinolytic drugs. Several reports confirm that application of TEM is cost effective by reducing the ... or in decision making for of alternative therapy such as antifibrinolytic drug administration . The clinical benefits of TEM ...

*Mouthwash

Zinc when used in combination with other anti-septic agents can limit the build-up of tartar Matthews, R W (2003). "Hot salt ... 4.8% tranexamic acid solution is sometimes used as an antifibrinolytic mouthwash to prevent bleeding during and after oral ... Chemotherapeutic agents, including mouthrinses, could have a key role as adjuncts to daily home care, preventing and ... Alcohol is added to mouthwash not to destroy bacteria but to act as a carrier agent for essential active ingredients such as ...

*Lonomia obliqua

It was discovered that the toxin in the caterpillar's skin held potent anti-clotting agents. This anti-clotting agent would ... Robert Norris, stings and abrasions caused by Lonomia obliqua should be treated with antifibrinolytics. If blood products are ...
Free download. Book file PDF easily for everyone and every device. You can download and read online Haemostasis in Cerebrospinal Fluid: Basic Concept of Antifibrinolytic Therapy of Subarachnoid Haemorrhage (Acta Neurochirurgica Supplement) file PDF Book only if you are registered here. And also you can download or read online all Book PDF file that related with Haemostasis in Cerebrospinal Fluid: Basic Concept of Antifibrinolytic Therapy of Subarachnoid Haemorrhage (Acta Neurochirurgica Supplement) book. Happy reading Haemostasis in Cerebrospinal Fluid: Basic Concept of Antifibrinolytic Therapy of Subarachnoid Haemorrhage (Acta Neurochirurgica Supplement) Bookeveryone. Download file Free Book PDF Haemostasis in Cerebrospinal Fluid: Basic Concept of Antifibrinolytic Therapy of Subarachnoid Haemorrhage (Acta Neurochirurgica Supplement) at Complete PDF Library. This Book have some digital formats such us :paperbook, ebook, kindle, epub, fb2 and another formats. Here is The CompletePDF Book Library. ...
Inclusion Criteria:. All trauma patients with ongoing significant haemorrhage (systolic blood pressure less than 90 mmHg and/or heart rate more than 110 beats per minute), or who are considered to be at risk of significant haemorrhage, and are within 8 hours of the injury, are eligible for trial entry if they appear to be at least 16 years old. Although entry is allowed up to 8 hours from injury, the earlier that patients can be treated the better.. Exclusion Criteria:. The fundamental eligibility criterion is the responsible doctors uncertainty as to whether or not to use an antifibrinolytic agent in a particular adult with traumatic haemorrhage. Patients for whom the responsible doctor considers there is a clear indication for antifibrinolytic therapy should not be randomised. Likewise, patients for whom there is considered to be a clear contraindication to antifibrinolytic therapy (such as, perhaps, those who have clinical evidence of a thrombotic disseminated intravascular coagulation) ...
Hemorrhagic shock and death from exsanguination remain common following traumatic injury. Attaining rapid hemostasis through control of bleeding, correction of acidosis, prevention of hypothermia, and maximization of coagulation can decrease mortality. Hemostasis remains challenging secondary to coagulopathy from dysfunctional hyperfibrinolysis, which is observed following major trauma and physiologic stress. Hyperfibrinolysis leads to clot degradation and ongoing blood loss. Early administration of Antifibrinolytic agents such as Tranexamic Acid (TXA) can reduce mortality in patients with traumatic hemorrhage.
NEWCASTLE, Australia --Three antifibrinolytic agents each reduced blood loss and red-cell transfusions associated with elective surgery, without an increased risk of thrombosis, according to a literat
Blood conservation strategies have become a standard of practice in cardiac surgery, with the use of antifibrinolytic agents and ultrafiltration two popular techniques. The purpose of this study was to evaluate the effects of continuous ultrafiltrati
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Varjú, Imre and Longstaff, Colin and Szabó, László and Farkas, Ádám Zoltán and Farkas, Veronika Judit and Tanka-Salamon, Anna and Machovich, Raymund and Kolev, Kraszimir Nikolaev (2015) DNA, histones and neutrophil extracellular traps exert anti-fibrinolytic effects in a plasma environment. Thrombosis and haemostasis, 113 (6). pp. 1289-1298. ISSN 0340-6245 Varjú, Imre and Tenekedjiev, Kiril and Keresztes, Zsófia and Pap, Andrea Edit and Szabó, László and Thelwell, Craig and Longstaff, Colin and Machovich, Raymund and Kolev, Krasimir (2014) Fractal Kinetic Behavior of Plasmin on the Surface of Fibrin Meshwork. BIOCHEMISTRY, 53 (40). pp. 6348-6356. ISSN 0006-2960 Machovich, Raymund and Kolev, Kraszimir and Komorowicz, Erzsébet and Léránt, István and Rábai, Gyöngyi and Wohner, Nikolett (2013) Trombolízis: a trombus celluláris és molekuláris komponenseinek hatása a fibrinolízisre = Thrombolysis: modulation of fibrinolysis by cellular and molecular components of thrombi. ...
Patients with OSAS have an increased cardiovascular risk. This may be due to several pathophysiological mechanisms, one of which is a hypercoagulable state. PAI-1 has a well-known antifibrinolytic role. High levels of this molecule have been associated with cardiovascular disease,27 and it could be responsible for the increased cardiovascular risk in OSAS.. Several studies have reported higher PAI-1 levels in subjects with OSAS compared with healthy subjects.11-15 However, in the literature, contrasting results can be found on the relationship between levels of PAI-1 and AHI, the index of the severity of OSAS. von Känel et al13 showed a positive correlation, whereas Zamarrón et al25 found an inverse correlation.. In our subjects with OSAS, we observed higher PAI-1 levels than in the control subjects. Moreover, we have shown a significant positive correlation between PAI-1 and the severity of OSAS, as measured by AHI, time ,90%, and ODI.. In the subjects with OSAS, endothelial cells are exposed ...
TY - JOUR. T1 - The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty. AU - Pachauri, Amit. AU - Acharya, Kiran K.. AU - Tiwari, Akhilesh Kumar. PY - 2014/1/1. Y1 - 2014/1/1. N2 - The aim of this study was to evaluate the efficacy of perioperative administration of 1,4-aminocarboxylic acid (tranexamic acid) in reducing the intraoperative and postoperative blood loss in patients undergoing total knee replacement (TKR). Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the effect of tranexamic acid on blood loss intraoperatively and postoperatively during and after TKR thereby significantly preventing a decrease in postop Hb in these patients. This study was a randomized, prospective, observational, double-blinded study on 99 patients, after obtaining ethical committee approval and valid informed consent from patients to be part of the study. In the study group, the drug was administered in 2 ...
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Product Name: Tranexamic Acid Injection. Common Name: antifibrinolytic injection. Strength: 100 mg / ml. Description: Tranexamic acid belongs to the class of medications called antifibrinolytic agents. Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss from trauma, surgery, and in various medical conditions including hemophilia and heavy menstrual bleeding. It comes in oral and intravenous forms.. Indications and Usage:. Tranexamic acid medication is used to prevent or reduce bleeding in certain conditions, such as dental surgery in people with hereditary blood clotting disorders, cervical surgery, heavy menstrual bleeding, nose bleeds and bleeding inside the eye.. In some medical conditions, the body breaks down blood clots too fast, not allowing the bleeding to stop and the wound to heal. Tranexamic acid works by blocking the breakdown of clots in the body.. Pack Size: Tranexamic Acid Injection is available in 5ml.. Minimum Order Quantity: 3000 ...
Antifibrinolytic therapy compared to placebo showed a significant reduction in mean blood loss (weighted mean difference (WMD) -94.0, 95% confidence interval (CI) -151.4 to -36.5]) and significant change in mean reduction of blood loss (WMD -110.2, 95% CI -146.5 to -73.8]). This objective improvement was not mirrored by a patient perceived improvement in monthly menstrual blood loss (relative risk (RR) 2.5, 95% CI 0.9 to 7.3) in the one study which recorded this outcome (Edlund 1995). Antifibrinolytic agents were compared to only three other medical (non-surgical) therapies: mefenamic acid, norethisterone administered in the luteal phase and ethamsylate. In all instances, there was a significant reduction in mean blood loss (WMD -73.0, 95% CI -123.4 to -22.6; WMD -111.0, 95% CI -178.5 to -43.5; and WMD -100, 95% CI -143.9 to -56.1 respectively) and a strong, although non-significant trend in favour of tranexamic acid in the participants perception of an improvement in menstrual blood loss. ...
Serious bleeding in cardiac surgery leads to re-exploration, blood transfusion and increases the risks of mortality and morbidity. Using the lysine analogous of antifibrionlytic agents are the preferred strategy to suppress the need for transfusion procedures and blood products. Although tranexamic acid has been very influential in reducing the transfusion requirement after operation, tranexamic acid induced seizures is one of the common side effects of this drug. Due to inhibiting the fibrinolysis, thrombotic events are other possible side effects of using tranexamic acid. There are no certain results regarding decreasing the mortality rate by using the drug but it is identified that tranexamic acid does not increase the mortality. In this article, we aimed to review the literature on using tranexamic acid in cardiac surgeries.
Antifibrinolytic medications such as tranexamic acid, aprotinin, and aminocaproic acid have proven to be useful in decreasing blood loss and the proportion of patients who require transfusion after a number of surgical procedures. In orthopedic surgery, tranexamic acid (TXA) is the best studied of these medications and a recent Cochrane Database review determined that tranexamic acid was effective in decreasing perioperative bleeding and post-operative transfusion after elective hip replacement and knee replacement surgery. At Mayo Clinic Rochester, the routine administration of tranexamic acid has evolved over the past decade to become part of the typical protocol for more than 3,000 elective hip and knee replacement procedures each year. Recent administrative data provides fairly compelling evidence of the efficacy of tranexamic acid in decreasing transfusion at the Mayo Clinic Rochester practice with 2010 data showing 2% and 7% prevalence of transfusion in patients treated with tranexamic ...
There has been concern about the usage of aprotinin, an antifibrinolytic drug that was often used in pediatric cardiac surgery until 2006. At our center, these concerns led to the replacement of aprotinin with tranexamic acid for antifibrinolytic tre
Maitreyee Mukherjee, MD1, Chandan Biswas, MD2, Sajib Chatterjee, MS3, Bijoy Kumar Bandyopadhyay, MD4. 1Assistant Professor; 2Senior Resident. Department of Anesthesiology & Critical Care, R. G. Kar Medical College & Hospital, 1, Kshudiram Bose Sarani, Kolkata, West Bengal 700004, (India). 3Department of General Surgery, Nil Ratan Sircar Medical College and Hospital (NRSMCH), 138, Acharya Jagadish Chandra Bose Rd, Sealdah, Raja Bazar, Kolkata, West Bengal 700014, (India). Correspondence: Dr. Maitreyee Mukherjee, Department of Anesthesiology & Critical Care, R. G. Kar Medical College & Hospital, 1, Kshudiram Bose Sarani, Kolkata, West Bengal 700004, (India); Mobile: 09830415924; E-mail: [email protected] ABSTRACT. Background: Femoral surgeries are always associated with excessive bleeding either in the intra-operative or postoperative period; often requiring blood transfusion. Induced hypotension and antifibrinolytics have been used to decrease blood loss. Agents used in this indication ...
The post-operative outcomes of 1,343 patients undergoing CABG with or without concomitant valve surgery between 1996 and 2005, and who received aprotinin, were compared with those of 6,776 patients who received aminocaproic acid and 2,029 patients who received no antifibrinolytic therapy (43). The mortality rate in the aprotinin group was 6.4%, compared with 2.4% in the aminocaproic acid group, and 2.2% for the group receiving no antifibrinolytic agent; after risk adjustment, the hazard ratio for death of patients treated with aprotinin compared with patients receiving no antifibrinolytic therapy or patients receiving aminocaproic acid was found to be 1.32 (95% CI: 1.12 to 1.55, p = 0.003) and 1.27 (95% CI: 1.10 to 1.46, p = 0.004), respectively. Aprotinin use was also associated with a larger risk-adjusted increase in serum creatinine (p , 0.0001).. Another retrospective database study published simultaneously reported a relative risk of in-hospital death of 1.32 (95% CI: 1.08 to 1.63) in a ...
Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss from major trauma, post partum bleeding, surgery, tooth removal, nose bleeds, and heavy menstruation.[1][2] It is also used for hereditary angioedema.[1][3] It is taken either by mouth or injection into a vein.[1]. Side effects are rare.[3] Some include changes in color vision, blood clots and allergic reactions.[3] Greater caution is recommended in people with kidney disease.[4] Tranexamic appears to be safe for use during pregnancy and breastfeeding.[3][5] Tranexamic acid is in the antifibrinolytic family of medications.[4]. Tranexamic acid was discovered in 1962 by Utako Okamoto.[6] It is on the World Health Organizations List of Essential Medicines, the most effective and safe medicines needed in a health system.[7] Tranexamic acid is available as a generic medication.[8] The wholesale cost in the developing world is about 4.38 to 4.89 USD for a course of treatment.[9] In the United States a course of ...
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Abstract Bilateral total knee arthroplasty (BTKA) patients may require blood transfusion which has its risks. Anti-fibrinolytic drugs such as aprotinin, aminocaproic acid and tranexamic acid (TXA) have reduced transfusion requirements in major surgery. This retrospective audit was performed to assess effectiveness of TXA in reducing blood transfusion rate in single-stage sequential BTKA cases operated by a single surgeon. Records of 91 patients given TXA and 80 controls who were operated before 2012 and not given TXA were reviewed. TXA was given 15mg/kg intravenously (IV) before tourniquet deflation and 3 hours postoperatively.Blood transfusion was done in 9(10%) patients in the TXA group compared to 20(25%)in the control group (p|0.01). One (1.25%) patient in the control group had non-fatal pulmonary embolism.TXA appeared to be effective in decreasing post-operative blood loss and requirement for blood transfusion after single-stage BTKA.
Plasmin is the effector protease of the fibrinolytic system, well known for its involvement in fibrin degradation and clot removal. However, plasmin is also recognized as a potent modulator of immunological processes by directly interacting with various cell types including leukocytes (monocytes, macrophages, and dendritic cells) and cells of the vasculature (endothelial cells, smooth muscle cells) as well as soluble factors of the immune system and components of the extracellular matrix. In fact, the removal of misfolded proteins and maintenance of tissue homeostasis seem to be major physiological functions of plasmin. However, a large body of evidence also suggests that excessive plasmin generation frequently contributes to the pathophysiology of acute and chronic inflammatory processes. Hence, one question arising from the broadening effects of plasmin in physiology is whether antifibrinolytic drugs (i.e., tranexamic acid, epsilon aminocaproic acid, or aprotinin) that target plasmin either directly
The evidence in this review suggests that the uncertainty about the effect of tranexamic acid on blood transfusion in surgical patients was resolved over a decade ago; however, uncertainties about its effect on thromboembolic events and mortality persist. Despite this, trials of tranexamic acid continue to assess the effect on blood transfusion. One reason may be a reluctance to generalise the evidence across surgery types, although there is no evidence that the relative effect of tranexamic acid on blood transfusion varies by type of surgery. A second reason may be that trialists are unaware of the existing evidence when initiating a new trial. Our observation that only half of the trials cited one or more of the available systematic reviews and just two carried out their own systematic review, does suggest that many trialists are indeed failing to adequately consider the existing evidence.. Blood is a scarce and costly resource and blood transfusion is not without risk. The cost of a unit of ...
The recombinant mature AcSecapin-1 peptide was expressed in baculovirus-infected insect cells. AcSecapin-1 functions as a serine protease inhibitor-like peptide that has inhibitory effects against plasmin, elastases, microbial serine proteases, trypsin, and chymotrypsin. Consistent with these functions, AcSecapin-1 inhibited the plasmin-mediated degradation of fibrin to fibrin degradation products, thus indicating the role of AcSecapin-1 as an anti-fibrinolytic agent. AcSecapin-1 also inhibited both human neutrophil and porcine pancreatic elastases. Furthermore, AcSecapin-1 bound to bacterial and fungal surfaces and exhibited anti-microbial activity against fungi and gram-positive and gram-negative bacteria ...
The objective of this study is to report a new manifestation of acute stroke following antifibrinolytic agent administration in young women carrying heterozygosity for methylene-tetrahydrofolate reductase (MTHFR) C677T. The study included two young women who developed an acute ischaemic stroke following three days of tranexamic acid administration for bleeding gynaecological disorders. Case 1, a 44-year-old woman, presented left hemiplegia, mild dysarthria and anosognosia. Brain magnetic resonance imaging showed right ischaemic fronto-temporal lesion due to subocclusion of the right middle cerebral artery. Case 2, a 49-year-old woman, developed aphasia and right hemiplegia. Neuroimaging showed left capsular and periventricular infarcts due to near occlusion of the left internal carotid artery. Thrombophilia screening, coagulation parameters, homocysteine testing, 12-lead electrocardiography, and transthoracic and transoesophageal echocardiography were unremarkable. Genetic assay showed that both ...
Tranexamic acid injection is an antifibrinolytic agent. It works by blocking the breakdown of blood clots. It may also be used for other conditions as determined by your doctor. This medicine is available only with your doctors prescription. This product is available in the following dosage forms:. ...
The risk-benefit balance of using tranexamic acid in cardiac surgical patients remains unclear. While tranexamic acid reduces the risk of bleeding among patients undergoing cardiac surgery, there are concerns that it may have prothrombotic and proconvulsant effects. In a trial with a 2-by-2 factorial design, patients scheduled to undergo coronary-artery surgery and at risk for perioperative complications were randomly allocated to receive aspirin or placebo and tranexamic acid or placebo. The results of the tranexamic acid comparison are reported here. The primary outcome was a composite of death and thrombotic complications (nonfatal myocardial infarction, stroke, pulmonary embolism, renal failure, or bowel infarction) within 30 days after surgery. Four thousand six hundred thirty-one patients underwent surgery and had available outcome data. A primary outcome event occurred in 386 patients (16.7%) in the tranexamic acid group and in 420 patients (18.1%) in the placebo group (relative risk, ...
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Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis.There is no experience with antifibrinolytic agents (tranexamic acid, aminocaproic acid) in individuals receiving rivaroxaban.Consider the benefits and risks before neuraxial intervention in.Most people who have hip replacement surgery will take XARELTO.When patients on warfarin need surgery REVIEW. should stop taking warfarin 5 days before elective surgery, and most do not need to receive heparin in the.Thrombolytics: 10 days (except for catheter clearance doses there are no restrictions ...
2017 The American Society of Colon and Rectal Surgeons, Inc. BACKGROUND: Lower GI hemorrhage is a common source of morbidity and mortality. Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clinical conditions. Information regarding the use of tranexamic acid in treating lower GI hemorrhage is lacking. OBJECTIVE: The aim of this trial was to determine the clinical efficacy of tranexamic acid when used for lower GI hemorrhage. DESIGN: This was a prospective, double-blind, placebo-controlled, randomized clinical trial. SETTINGS: The study was conducted at a tertiary referral university hospital in Australia. PATIENTS: Consecutive patients aged ,18 years with lower GI hemorrhage requiring hospital admission from November 2011 to January 2014 were screened for trial eligibility (N = 265). INTERVENTIONS: A total of 100 patients were recruited after exclusions and were randomly assigned 1:1 to either tranexamic acid or placebo. MAIN OUTCOME MEASURES: The ...
... , an antifibrinolytic, is used off label to reduce bleeding in certain kinds of surgery, including major orthopedic and spine
BACKGROUND The objective of this meta-analysis was to evaluate the efficacy and safety of tranexamic acid (TXA) in shoulder arthroplasty (SA). METHODS Academic articles were identified from the Cochrane Library, Medline (1966-2017.2), PubMed (1966-2017.2), Embase (1980-2017.2), and ScienceDirect (1966-2017.2). Randomized controlled trials (RCTs) and non-RCTs studying TXA in SA were included. Two independent reviewers conducted independent data abstraction. The I statistic was used to assess heterogeneity. Fixed- or random-effects models were used for meta-analysis. RESULTS Two RCTs and 2 non-RCTs met the inclusion criteria. This meta-analysis found significant differences in postoperative hemoglobin reduction (MD = -0.71 g/dL), drainage volume (MD = -133.21 mL), and total blood loss (MD = -226.82 mL) between TXA groups and controls. There were no significant differences in blood transfusion requirements, operation time, or length of hospital stay. CONCLUSIONS The use of TXA in SA decreases
The purpose of this meta-analysis is to evaluate the efficacy and safety of tranexamic acid (TXA) for patients with degenerative lumbar disc herniation, stenosis or instability undergoing posterior lumbar fusion (PLF) surgery. We searched PubMed, Embase, and Cochrane Library until May 1, 2018. Two reviewers selected studies, assessed quality, extracted data, and evaluated the risk of bias independently. Weighted mean difference (WMD) and relative risk (RR) were calculated as the summary statistics for continuous data and dichotomous data, respectively. We chose fixed-effects or random-effects models based on I2 statistics. RevMan 5.0 and STATA 14.0 software were used for data analysis. Nine studies enrolling 713 patients for the study. The pooled outcomes demonstrated that TXA can decrease total blood loss (TBL) in patients underwent PLF surgery [WMD = -250.68, 95% CI (− 325.06, − 176.29), P|0.001], intraoperative blood loss (IBL) [WMD = -72.57, 95% CI (− 103.94, − 41.20), P|0.001],
Tranexamic acid is a blood-clotting agent used in everything from soldiers wounds to dental surgery. It can cost as little as $1 a dose.
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1 Answer - Posted in: tranexamic acid, depo, bleeding - Answer: If the dr has intended for you to do that, then yes. If not call the dr ...
In 2010, CRASH-2 (Clinical Randomization of an Antifibrinolytic in Significant Haemorrhage-2) demonstrated that TXA safely reduces the risk of death in adult (age ≥16 years) trauma. This was the first study to show a medical treatment for trauma and a reduction in mortality. This randomized placebo-controlled trial involved 20,211 patients in 40 countries. Adult patients with unstable vitals (systolic blood pressure ,90 mmHg and/or heart rate ,110 beats per minute, or both) or a high clinical suspicion for significant hemorrhage were randomized to TXA versus placebo. The primary outcome, in-hospital mortality at 4 weeks, showed a significant reduction in risk of death due to bleeding for the TXA group (risk of death 0.85; 95% confidence interval 0.76 to 0.96; P = 0.004, number needed to treat (NNT) 121) and all-cause mortality for the overall population (risk of death 0.91; 95% confidence interval 0.85 to 0.97; P = 0.0035, NNT 67). TXA appeared to have the greatest impact on reduction of death ...
Overdose Despite the relative specificity of drug effects on fibrin, an overdose may result in a clinically significant reduction in the level of fibrinogen and other clotting factors. In most cases it is enough to stop the introduction of Actilyse ® and wait for the physiological recovery of these factors. However, if you develop severe bleeding, recommended infusion of fresh frozen plasma or fresh blood; if necessary, you can assign a synthetic antifibrinolytic agent. Interactions with other medications No specific studies interaction jelfa omnadren of Actilyse ® with other drugs commonly used in acute myocardial infarction, have been conducted. The use of drugs that affect blood clotting or altering platelet function prior to, during or after the initiation of therapy Micardis ® may increase the risk of bleeding. Concomitant use of ACE inhibitors may increase the risk of anaphylactoid reactions. These reactions are observed in a relatively large proportion of patients treated with ACE ...
Overdose Despite the relative specificity of drug effects on fibrin, an overdose may result in a clinically significant reduction in the level of fibrinogen and other clotting factors. In most cases it is enough to stop the introduction of Actilyse ® and wait for the physiological recovery of these factors. However, if you develop severe bleeding, recommended infusion of fresh frozen plasma or fresh blood; if necessary, you can assign a synthetic antifibrinolytic agent. Interactions with other medications No specific studies interaction jelfa omnadren of Actilyse ® with other drugs commonly used in acute myocardial infarction, have been conducted. The use of drugs that affect blood clotting or altering platelet function prior to, during or after the initiation of therapy Micardis ® may increase the risk of bleeding. Concomitant use of ACE inhibitors may increase the risk of anaphylactoid reactions. These reactions are observed in a relatively large proportion of patients treated with ACE ...
CRASH-2 trial came out in 2010 to answer this question: What are the effects of the early administration of a short course of tranexamic acid on death in trauma patients with or at risk of significant haemorrhage? CRASH-2 trial is a large placebo controlled trial undertaken in 276 hospitals in 40 countries. Discussion: Patients were included if the…
All adult trauma patients who are considered to be at risk of significant haemorrhage and are within 8 hours of the injury, are eligible for trial entry if they appear to be at least 16 years old. There are no other pre-specified exclusion criteria, as the fundamental eligibility criterion is the responsible doctors uncertainty whether or not to use tranexamic acid (TXA) in a particular adult with traumatic haemorrhage. Patients for whom there is considered by the responsible doctor to be a clear indication for TXA should not be randomised. Likewise, any for whom there is considered to be a clear contraindication to TXA (such as, perhaps, those who have clinical evidence of a thrombotic disseminated intravascular coagulation) should not be randomised. All those for whom the responsible doctor is substantially uncertain as to whether or not to use an anti-fibrinolytic agent are eligible for randomisation, and as many such patients as possible should be considered for the trial. ...
Post-partum hemorrhage or severe bleeding in mothers after childbirth could be treated using tranexamic acid as a frontline response, reveals study.
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You really were paying attention! Full circle we come. Although blood is not all things to everybody, and has its own negatives and caveats, at the present date if you lose blood the best replacement is blood. Of some kind.. Of what kind remains a bit of a mystery. Men in white coats continue to play with different mixtures of red cells, and plasma, and platelets, and even various concentrates and precipitates of specific clotting factors. One of the latest miracle additions is tranexamic acid, which antagonizes natural thrombolytics (remember plasmin?) and seems to reduce bleeding. There are also cool devices, used mainly during surgery, that "salvage" your own lost blood, rinse it off, and give it right back to you, which obviously simplifies some things.. Of note is an approach to transfusion developed by the anaesthesiologists at Shock Trauma in Baltimore. They like to give PRBCs and plasma until you reach a reasonably permissive pressure. Then they bolus some opiate goodness (fentanyl is ...
Looking for Aminocaproic acid? Find out information about Aminocaproic acid. 1. any substance that dissociates in water to yield a sour corrosive solution containing hydrogen ions, having a pH of less than 7, and turning litmus red... Explanation of Aminocaproic acid
Aminocaproic acid is an anti-fibrinolytic agent (an agent that prevents the breakdown of fibrin, a protein needed for proper blood clotting). R.M. Clemmons, Associate Professor of Neurology and Neurosurgery at the University of Florida Veterinary College advocates its use in the treatment of degenerative myelopathy (DM), a condition in which nerve tissue breaks down, in German Shepherds. While aminocaproic acid has been shown to provide very little benefit in the treatment of spinal cord trauma, Dr. Clemmons believes it can contribute significantly to a favorable outcome in up to eighty percent of cases of German Shepherd degenerative myelopathy (GSDM), especially when used with other supplements and diets. Details on the protocol can be found at http://neuro.vetmed.ufl.edu/neuro/DM_Web/DMofGS.htm.. Aminocaproic acid is used to intervene at a critical stage in the development of GSDM. Dr. Clemmons believes that the spinal cord is indirectly attacked by the immune system in degenerative ...
Aminocaproic acid is an anti-fibrinolytic agent (an agent that prevents the breakdown of fibrin, a protein needed for proper blood clotting). R.M. Clemmons, Associate Professor of Neurology and Neurosurgery at the University of Florida Veterinary College advocates its use in the treatment of degenerative myelopathy (DM), a condition in which nerve tissue breaks down, in German Shepherds. While aminocaproic acid has been shown to provide very little benefit in the treatment of spinal cord trauma, Dr. Clemmons believes it can contribute significantly to a favorable outcome in up to eighty percent of cases of German Shepherd degenerative myelopathy (GSDM), especially when used with other supplements and diets. Details on the protocol can be found at http://neuro.vetmed.ufl.edu/neuro/DM_Web/DMofGS.htm.. Aminocaproic acid is used to intervene at a critical stage in the development of GSDM. Dr. Clemmons believes that the spinal cord is indirectly attacked by the immune system in degenerative ...
Background and Aims: Tranexamic acid has been used to decrease blood loss volumes and the subsequent need for blood transfusion in the orthopedic, spinal and cardiac surgeries. Methods: In this prospective controlled randomized clinical trial study, 24 candidates for orthognathic surgeries received tranexamic acid (20 mg/kg) intravenously just before the surgery while matched control patients received normal saline. The patients underwent the surgeries according to the standard protocol. Patients blood hemoglobin and hematocrit levels were calculated before and after the surgeries and blood loss volumes were calculated using these criteria. Results: The blood loss was estimated as 693.65 ± 81.24 and 1024.00 ± 75.41 ml regarding blood hemoglobin values before and after the surgery in intervention and control groups, respectively; while it was estimated as 660.93 ± 62.78 and 1052.00 ± 48.54 ml concerning patients blood hematocrit levels before and after the surgery in those groups, respectively.
Unfortunately, retired racing greyhounds are among the large breeds that are most likely to get osteosarcoma, a type of bone cancer. Finding a cure is part of our mission, and while we work to find that cure we are offering our members free carboplatin* and epsilon aminocaproic acid (i.e., "Amicar™"). See the Programs page for details.. *Carboplatin is the best drug for the treatment of osteosarcoma in Greyhounds. Some vets like to use an alternating protocol of carboplatin and doxorubicin, but that is actually less effective in Greyhounds. Epsilon aminocaproic acid (EACA) is the generic form of Amicar™ that is recommended for use for 5 days starting with any surgical procedure to prevent the post-operative bleeding that is common in Greyhounds.. ...
Aminocaproic acid injection is an antifibrinolytic agent. It is used to treat serious bleeding conditions, especially when the bleeding occurs after dental surgery or other kinds of surgery. This medicine is also sometimes given before an operation to prevent serious bleeding for patients with medical problems that increase the chance of bleeding.
Background:Proximal Femoral shaft fractures are commonly associated with marked blood loss which can lead topostoperative acute anemia and some other complications.Tranexamic acid (TA) is an antifibrinolytic medication that reduces intra-and postoperative blood loss and transfusionrequirements during some elective surgeries (1-3).The aim of this study is to evaluate the effect of intravenous Tranexamic acid (TA) on intraoperative blood loss and asubsequent need for transfusion in patients who were undergoing surgery for femoral shaft fractures in trauma setting.Methods:Thirty-eight ASA grade I-II patients undergoing proximal femoral shaft fracture surgery with intra medullarynailing were included in this double blind randomized controlled clinical trial. They were allocated into two groups. GroupI, the intervention group with eighteen patients received 15 mg/kg (TA) via intravenous infusion before surgical incision.Patients in the placebo group received an identical volume of normal saline.Hemoglobin
Generic AMINOCAPROIC ACID availability. Has a generic version of AMINOCAPROIC ACID been approved? Find suppliers, manufacturers, and packagers
As I understand it - Etamsylate promotes blood clotting through coagulation, Tranexamic Acid inhibits the process your body uses to break up blood clots (an antifibrinolytic), and Yunnan Baiyao is an herb which may have some use in stopping internal bleeding (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992384/) although the mechanism doesnt seem to be understood yet. Tranexamic Acid at least has had a lot of recent studies done, and seems to be recommended for combat injuries where a lot
Whitening Serum Tranexamic Acid 1197-18-8 Amstat Decrease Operation Hemorrhage Basic Views Name:Tranexamic acid Alias: Amstat Synonym: TIMTEC-BB SBB006715; TRANS-4-AMINOMETHYL-1-CYCLOHEXANECARBOXYLIC ACID;...
NEX PHARMA PVT. LTD. - Manufacturer, Distributor, Supplier, Trading Company of Tranexamic Acid & Mefenamic Acid Tablets based in Bhiwani, India
Learn about Amicar (Aminocaproic Acid) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Do not take this medicine during pregnancy. Do not use this medicine for kidney or bladder bleeding unless directed by your doctor. Aminocaproic acid (Amicar) should be used with caution in patients with heart, kidney, or liver disease.. You and your child should know the names of all the medicines he or she is taking. Share this information with anyone involved in your childs care.. Always make sure you have enough medicine on hand. Each time you refill your prescription, check to see how many refills are left. If no refills are left the pharmacy will need 2 or 3 days to contact the clinic to renew the prescription.. Check the label and expiration date before giving each dose. Ask your pharmacist what to do with outdated or unused medicines. If there is no "take-back" program empty them into the trash.. Store all medicines in their original container and away from direct sunlight or heat. Do not store in humid places such as the bathroom. Keep them out of childrens reach, locked up if ...
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Creative Peptides offers ε- Aminocaproic acid for your research. We also provide custom peptide synthesis, process development, GMP manufacturing.
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Systemic epsilon aminocaproic acid (Amicar)-Slows clot lysis by preventing plasmin from binding to fibrin clot lysine; May reduce incidence of hyphema recurrence at dose of 50-100mg/kg Q4h x 5d, max 30g/d; Only for use with hyphema occupying , 75% of anterior chamber; contraindicated in pregnancy or hepatic or renal ...
Thrombin activatable fibrinolysis inhibitor (TAFI) is a human plasma-derived zymogen that is activated through proteolytic cleavage by thrombin, thrombin in complex with thrombomodulin, or plasmin. Active TAFI attenuates fibrinolysis by removing carboxyl-terminal lysine residues from partially degraded fibrin, thereby inhibiting a potent positive feedback loop in the fibrinolytic cascade. In addition to the plasma pool of TAFI arising from expression in the liver, a distinct pool of TAFI has been reported to be present in platelets. While the antifibrinolytic effect of plasma-derived TAFI has been well-documented by in vitro and in vivo clot lysis assays, characterization of the platelet-derived form has been limited. Here, we not only confirm the presence of TAFI in the medium of washed, thrombin-stimulated platelets, but also that platelet-derived TAFI is capable of attenuating platelet-rich thrombus lysis in vitro independently of plasma TAFI using a novel thrombus lysis assay. Fluorescent ...
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We investigated the effects of tranexamic acid in 40 patients who had received cementless total hip arthroplasty (THA) in a prospective, randomized study. In 20 patients, 1000 mg of whole-body tranexa
BACKGROUND and OBJECTIVE:. Searching for the ideal pleurodesis agent still continues, Bleomycin is one of the most commonly used agents for pleurodesis. Tranexamic acid have been reported as a cheap pleurodesis agent by many authors. In this study, we evaluate the efficacy, safety and cost of using a combination of bleomycin and Tranexamic acid versus each agent alone.. METHODS:. Sixty three patients with massive malignant pleural effusions were divided in 3 equal groups in a simple randomized manner. Tranexamic acid (30 mg/kg [maximum of 2 g] in 50 mL of normal saline) was administered through a chest tube in Group 1. Group 2 received bleomycin (1 U/kg [maximum of 60 U] in 70 mL of normal saline). Group 3 received the above 2 preparations (tranexamic acid, 30 mg/kg [maximum of 2 g] in 40 mL of normal saline and bleomycin, 1 U/kg [maximum of 60 U] in 50 mL of normal saline) instilled one following the other by 15 minutes. Follow-up CXR examinations were performed at 7 days, 30 days, 60 days and ...
Texakind (500mg) - 10 Tablet (Tranexamic Acid) drug information. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. It is manufactured by Mankind Pharma Pvt. Ltd.
Question - Having intramural fibroids. Tried mefenamic acid, tranexamic acid and hormone pills. Severe bleeding and vomiting. Will mirena coil help ?. Ask a Doctor about uses, dosages and side-effects of Mirena, Ask an OBGYN, Gynecologic Oncology
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PONTES, José Carlos D. V. et al. Comparative study of low-dose aprotinin x placebo during cardiopulmonary bypass. Rev Bras Cir Cardiovasc [online]. 2002, vol.17, n.1, pp.47-53. ISSN 0102-7638. http://dx.doi.org/10.1590/S0102-76382002000100008.. BACKGROUND: The use of aprotinin, a antifibrinolytic agent, has been shown to decrease damaging effects on cardiopulmonary bypass in fibrinolytic system, which may improve hemostasis. OBJECTIVE: To study the effect of low dose aprotinin in patients undergoing extracorporeal circulation. METHOD: Seventeen patients, underwent cardiopulmonary bypass to mitral valve replacement, was ramdomized in two groups: I (control) ¾ 9 patients received placebo after anesthesia induction and each hour in the priming; II (aprotinin) ¾ 8 patients received after anesthesia induction 30,000 KIU/kg and 7.500 KIU/kg each hour in the priming during the perfusion. The blood loss was observed through the first 24 hours postoperatively. Arterial blood samples were taken after ...
en] BACKGROUND: Numerous articles describe the reduction of perioperative bleeding by the therapeutic or prophylactic administration of drugs such as prostacyclin, desmopressin, and natural or synthetic antifibrinolytics. METHODS: A review of the literature was carried out to help the reader define the indications of these drugs during cardiopulmonary bypass operations, highlight the questions that remain concerning their indications and modes of action, and suggest future studies to answer these remaining questions. RESULTS: Prostacyclin reduces platelet trauma induced by extracorporeal circulation but does not effectively reduce postoperative bleeding and transfusion requirements. Desmopressin acts as a glue, improving platelet adhesion, and may be effective when postoperative bleeding is excessive, but its routine use in cardiac operations cannot be recommended. Natural and synthetic antifibrinolytics inhibit plasmin and plasmin-induced platelet dysfunction. These agents have been shown to ...
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Most of the data in the review came from the international CRASH-2 trial,4 which recruited 20 211 patients with bleeding trauma from some 40 countries world wide and showed that TXA significantly reduces mortality with no apparent increase in the risk of vascular occlusive events. Because the CRASH-2 results are based on large numbers of patients, with both blunt and penetrating trauma, and from many different countries, they can be generalised widely. Given the high quality of evidence for the benefits of this drug, the authors recommend that TXA is considered for use in every patient with severe bleeding from traumatic injury.. Studies are now underway to see if TXA can reduce deaths from post partum haemorrhage5 (which kills about 100 000 women each year, most of whom live in developing countries) and traumatic intracranial bleeding which is a major cause of death and disability. Further interactive material on the topic is available through the Cochrane Journal Club.6. The review mentioned ...
The review addressed a clear question that was defined in terms of the participants, interventions, outcomes and study design. Only one database was searched and some authors were contacted, which might have resulted in the omission of other relevant studies. It was unclear whether any language restrictions had been applied, thus the potential for language bias could not be assessed. Only one author selected the studies and this lack of duplication might have led to errors and bias. In addition, the methods used to extract the data were not described, so it is not known whether any efforts were made to reduce reviewer error and bias. Study validity was not assessed, thus the results from these studies and any synthesis might not be reliable. Statistical heterogeneity was assessed and the studies were generally appropriately pooled using meta-analysis. The evidence presented appears to support the authors conclusions, but the reliability of the review findings are weakened by the limited search, ...
Intern 100 mg/kg la fiecare 4 ore. Doza pentru 24 ore este de 10-15 g. In hemoragiile acute se recomanda administrarea i.v. pana la 4-5 g prima ora (diluat in 250 ml solutie salina isotona, apoi cate 1 g (in 50 ml) fiecare ora. Perfuzia se prelungeste pana la oprirea hemoragiei insa nu mai mult de 8 ore. In hipofibrinogenemia acuta pana la 100 ml solutie perfuzabila i.v. La necesitate doza poate fi repetata peste 4 ore. Granulele se dizolva in apa proaspat fiarta pana la semnul 100 ml. Solutia obtinuta contine 0,2 g acid aminocaproic in 1 ml. Copii sub 1 an 2,5 ml, 2-6 ani 2,5-5 ml, 7-10 ani 5-7 ml de 3 ori pe zi. In hemoragiile acute, copii sub 1 an 5 ml, 2-4 ani 5-7,5 ml, 5-8 ani 7,5-10 ml, 9-10 ani 15 ml de 3 ori pe zi. Cura de tratament constituie 3-14 zile.. ...
Four innovative studies exploring ways to reduce complications related to heart surgery or minimize patient mortality due to risks associated with low blood pressure and surgery were highlighted during the Anesthesiology Major Trials Session held at the ANESTHESIOLOGY® 2016 annual meeting.
distress syndrome, (d) corticosteroids in traumatic head injury, (e) tirilazad in acute ischaemic stroke, (f) antifibrinolytics in haemorrage.. The authors conclude that in cases (a), (b), (c) there ...
My research interests include the effects of ischaemic conditioning in stroke; the role of cannabinoids in the vasculature and blood brain barrier; colony stimulating factors and haematopoietic stem cells in enhancing stroke recovery; and blood pressure and stroke.. I am the Chief Investigator of the BMA funded ReCAST (Remote Iscahemic Conditioning After Stroke Trial) and sit on the Trial Steering Committees for TICH-2 (Tranexamic acid in Intracerebral Haemorrhagic) and RIGHT-2 (Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2). I also sit on the Trial Management Group for BEADS (BEhavioural Activation therapy for Depression after Stroke). ...
Author: Zhang Yan-ping, Trissel Lawrence A, Year: 1997, Abstract: The purpose of this study was to determine the stability of aminocaproic acid 10 and 100 mg/mL admixed in 5% dextrose injection and 0.9% sodium chloride injection in polyvinyl chloride bags over periods up to seven days at 4° and 23°C.

The aminocaproic acid 250-mg/mL injection was filtered and admixed in filtered 5% dextrose injection and 0.9% sodium chloride injection to yield nominal aminocaproic acid concentrations of 10 and 100 mg/mL. Evaluations were performed initially and af

Objective Postpartum hemorrhage (PPH) is a major cause of maternal mortality, with almost 300,000 cases and approximately 72,000 PPH deaths annually in sub-Saharan Africa. Novel prevention methods practical in community settings are required. Tranexamic acid, a drug to reduce bleeding during surgical cases including postpartum bleeding, is potentially suitable for community settings. Thus, we sought to determine the impact of tranexamic acid on PPH-related maternal mortality in sub-Saharan Africa.
... Published by QYResearch at researchbeam.com . Global Tranexamic Acid Industry 2015 Deep Market Research Report is a research report by Key Manufacturers, Applications, Developments and Trends with covering regions China, US, Europe & Japan
We conducted a retrospective cohort study (N = 477) to determine if use of intravenous tranexamic acid (TXA) improves early ambulation and reduces blood loss after total knee arthroplasty and anterior and posterior total hip arthroplasty. Mean (SD) patient age was 66.5 (10.1) years. For all 3 procedures, early ambulation was significantly better in the TXA group than in the no-TXA group at postoperative days 1 and 2, and, over time, reductions in hemoglobin and hematocrit were statistically significantly lower in the TXA group than in the no-TXA group. TXA groups required fewer postoperative transfusions. Incidence of postoperative venous thromboembolism was similar between all groups. TXA use improves early ambulation after total joint arthroplasty.
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Total knee arthroplasty usually has an important blood loss which may lead patients to receive allogeneic blood transfusion up to 30-45% of cases. Allogeneic blood transf..
Despite having many studies to evaluate the role of TXA in surgeries, limited literature is available on its role in hip fracture surgeries. In an RCT, TXA was administered as an initial bolus dose of 500mg before surgery followed by continuous infusion at 1mg/kg/h for the duration of surgery. Results showed that the differences in mean reduction in Hb and mean volume of blood loss postoperatively between TXA and placebo groups were significant. In addition, only 7 out of 45 patients in TXA group required blood transfusion compared to 18 out of 45 in placebo group and the difference was again significant.5 On the contrary, another RCT in 2010 concluded that there was no significant difference in blood transfusion rates between TXA and placebo groups after surgery for hip fracture.3 Therefore, although effectiveness of TXA in reducing post-surgical blood loss and transfusion requirements have been shown by multiple studies, but its effectiveness, specifically in hip fracture surgeries, is yet to ...
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A growing body of evidence has shown tranexamic acid (TXA) to be effective in decreasing perioperative blood loss and transfusion requirements in both primary and revision hip and knee arthroplasty.
2016 Global and Chinese 6-Aminocaproic Acid (CAS 149-57-5) Industry Market Research Report is a market research report available at US $2800 for a Single User PDF License from RnR Market Research Reports Library.
Treatment for VWD depends on the diagnosis and severity. The mainstay of treatment is DDAVP (desmopressin acetate), the synthetic version of a natural hormone vasopressin,. It stimulates the release of VWF from cells, which also increases FVIII.DDAVP comes in two forms: injectable and nasal spray. Because DDAVP is an antidiuretic, causing the body to retain water, fluid restrictions are important so patients dont develop hyponatremia, reduced sodium in the bloodstream.. There are a few clotting factor concentrates that are rich in VWF, and are recommended for patients with VWD. These therapies are given by intravenous infusion. In December 2015, the US Food and Drug Administration (FDA) approved Baxaltas Vonvendi®, the first recombinant VWF product. Unlike other products, it contains VWF only, not VWF and factor VIII. It is approved to treat on-demand and for control of bleeding in adults 18 and older.. Aminocaproic acid and tranexamic acid are antifibrinolytics agents that prevent the ...
Hereditary deficiency of C1 inhibitor (C1 INH) Congenital deficiency of functional C1 INH Clinically manifests as hereditary angioedema (Quincke 1882, Osler 1888) C1-INH is central to the regulation of the complement coagulation and kinin-forming systems Clinical symptoms: swelling, abdominal attacks, edema of the upper airway Treatment: acute attacks - C1-INH concentrate; prophylactic - androgens or antifibrinolytic agents
Toda la información sobre las últimas publicaciones científicas de la Clínica Universidad de Navarra. Tranexamic acid-induced toxic epidermal necrolysis
0138]Synthesis of 4-[(5-aminopentyl)carbonylamino]-2,2,6,6-tetramethylpiperidine-1-oxyl. Mixture of 1.31 g (10 mM) of 6-aminocaproic acid and 4.5 ml of trifluoroacetic anhydride was heated for 2 h at 80° C. in soldered ampoule. Volatile components of the reaction mixture were evaporated at reduced pressure. The residual liquid consisted mainly of bis-trifluoroacetylated 6-aminocaproic acid. To achieve hydrolysis of mixed anhydride function of this intermediate, 0.25 ml (14 mM) of water was added to it with ice cooling. The solution was left for 1 h at ˜20° C. and after that it was azeotroped with three 10 ml portions of dry benzene. The yield of 6-(trifluoroacetylamino)caproic acid was 2.27 g, mp 83° C. It was dissolved in 10 ml of ethyl acetate and triethylamine (1.39 ml, 10 mM) and ethyl chloroformate (0.96 ml, 10 mM) were added sequentially at ice bath cooling and stirring. After stirring for 20 min at the same cooling, solution of 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl (1.71 g, 10 ...
The ability of human embryonic stem cells (hESCs) and their derivatives to differentiate and contribute to tissue repair has enormous potential to treat various debilitating diseases. However, improving the in vivo viability and function of the transplanted cells, a key determinant of translating cell-based therapies to the clinic, remains a daunting task. Here, we develop a hybrid biomaterial consisting of hyaluronic acid (HA) grafted with 6-aminocaproic acid moieties (HA-6ACA) to improve cell delivery and their subsequent in vivo function using skeletal muscle as a model system. Our findings show that the biomimetic material-assisted delivery of hESC-derived myogenic progenitor cells into cardiotoxin-injured skeletal muscles of NOD/SCID mice significantly promotes survival and engraftment of transplanted cells in a dose-dependent manner. The donor cells were found to contribute to the regeneration of damaged muscle fibers and to the satellite cell (muscle specific stem cells) compartment. Such ...

The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty<...The effect of tranexamic acid on hemoglobin levels during total knee arthroplasty<...

Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the ... Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the ... Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the ... Tranexamic acid is an antifibrinolytic agent that is 7-10 times as potent as epsilon aminocaproic acid. We had investigated the ...
more infohttps://manipal.pure.elsevier.com/en/publications/the-effect-of-tranexamic-acid-on-hemoglobin-levels-during-total-k

Tranexamic Acid Injection - Zuche PharmaceuticalsTranexamic Acid Injection - Zuche Pharmaceuticals

Tranexamic acid belongs to the class of medications called antifibrinolytic agents. Tranexamic acid (TXA) is a medication used ...
more infohttp://zuchepharma.com/pharmaceuticals/tranexamic-acid-injection/

Tranexamic Acid Injection,Cyklokapron Tranexamic Acid Injection,Injectable Tranexamic Acid ExportersTranexamic Acid Injection,Cyklokapron Tranexamic Acid Injection,Injectable Tranexamic Acid Exporters

The internationally acclaimed Tranexamic Acid Injection is an anti-fibrinolytic agent for reliable and safe control of acute ...
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Factor XIII Deficiency Medication: Clotting factors, Blood Products, Antifibrinolytic agentsFactor XIII Deficiency Medication: Clotting factors, Blood Products, Antifibrinolytic agents

Antifibrinolytic agents. Class Summary. These agents are used as an ancillary measure and to diminish bleeding. ... Use antifibrinolytic agents with fresh frozen plasma (FFP) replacement for minor surgical procedures (eg, dental extractions or ... 123] EACA is the most widely used antifibrinolytic drug in the United States. The minimal dose needed to inhibit either normal ... However, its antifibrinolytic effect lasts longer than EACA. AMCA inhibits fibrinolysis at lower plasma concentrations, ...
more infohttps://emedicine.medscape.com/article/209179-medication

Leicester Research Archive: Antifibrinolytic agents in traumatic haemorrhage.Leicester Research Archive: Antifibrinolytic agents in traumatic haemorrhage.

Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage), a large, multi-centre, randomised controlled trial ...
more infohttps://lra.le.ac.uk/handle/2381/17041?mode=full

Pediatric Angioedema Medication: Androgens, Antifibrinolytic Agents, Blood Products, Sympathomimetic Agents, Kallikrein...Pediatric Angioedema Medication: Androgens, Antifibrinolytic Agents, Blood Products, Sympathomimetic Agents, Kallikrein...

Antifibrinolytic Agents. Class Summary. These agents have been successfully used as preventive therapy. The effect may depend ... Sympathomimetic Agents. Class Summary. These agents directly or indirectly stimulate adrenergic receptors. They are used as ... Aminocaproic acid is an antifibrinolytic agent used for immediate short-term treatment of angioedema. It inhibits fibrinolysis ... This agent increases levels of C4 component of complement and reduces attacks associated with angioedema. In HAE, danazol ...
more infohttps://emedicine.medscape.com/article/885100-medication

Oral nimodipine reduces prostaglandin and thromboxane production by arteries chronically exposed to a periarterial haematoma...Oral nimodipine reduces prostaglandin and thromboxane production by arteries chronically exposed to a periarterial haematoma...

All rabbits were given the antifibrinolytic agent tranexamic acid to retard resolution of the clot, and half were given oral ... and thromboxane production by arteries chronically exposed to a periarterial haematoma and the antifibrinolytic agent ... and thromboxane production by arteries chronically exposed to a periarterial haematoma and the antifibrinolytic agent ...
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Antifibrinolytic Agents | Perfusion LTAntifibrinolytic Agents | Perfusion LT

Upon successful completion of course modules and an exam grade of 80 or higher, the student will be awarded 2 Category II CEU by the American Board of Cardiovascular Perfusion.. ...
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Aminocaproic Acid
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        Antifibrinolytic Agents,  ATC:B02AA01Aminocaproic Acid - Antifibrinolytic Agents, ATC:B02AA01

Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. The fibrinolysis-inhibitory ...
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Tioconazolum [INN-Latin]
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        Antifibrinolytic Agents,  ATC:B02AA02Tioconazolum [INN-Latin] - Antifibrinolytic Agents, ATC:B02AA02

Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin. Tranexamic acid is ...
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Apitherapy News: Bee Venom Peptide is Anti-Fibrinolytic, Anti-Microbial AgentApitherapy News: Bee Venom Peptide is Anti-Fibrinolytic, Anti-Microbial Agent

Bee Venom Peptide is Anti-Fibrinolytic, Anti-Microbial Agent Secapin, a bee venom peptide, exhibits anti-fibrinolytic, anti- ... venom peptide secapin has multifunctional roles as an anti-fibrinolytic agent during fibrinolysis and an anti-microbial agent ... thus indicating the role of AcSecapin-1 as an anti-fibrinolytic agent. AcSecapin-1 also inhibited both human neutrophil and ... Here, we provide the evidence that Asiatic honeybee (Apis cerana) secapin (AcSecapin-1) exhibits anti-fibrinolytic, anti- ...
more infohttp://apitherapy.blogspot.com/2016/05/bee-venom-peptide-is-anti-fibrinolytic.html

37 - Heritable Bleeding Disorders Flashcards by David Thomas | Brainscape37 - Heritable Bleeding Disorders Flashcards by David Thomas | Brainscape

Antifibrinolytics. DDAVP - for type I vWD. Factors containing concentrates of vWF. Vaccination against hepatitis COCP (combined ... 1 Introduction To Antibacterial Agents * 2 Mechanisms Of Antibiotic Resistance * 3 Antivirals ...
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Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage - Full Text View - ClinicalTrials.govClinical Randomisation of an Antifibrinolytic in Significant Haemorrhage - Full Text View - ClinicalTrials.gov

Antifibrinolytic Agents. Fibrin Modulating Agents. Molecular Mechanisms of Pharmacological Action. Hemostatics. Coagulants. ... Coats T, Hunt B, Roberts I, Shakur H. Antifibrinolytic agents in traumatic haemorrhage. PLoS Med. 2005 Mar;2(3):e64. Epub 2005 ... as to whether or not to use an antifibrinolytic agent in a particular adult with traumatic haemorrhage. Patients for whom the ... eligible if the responsible doctor is for any reason substantially uncertain whether or not to use an antifibrinolytic agent. ...
more infohttps://clinicaltrials.gov/show/NCT00375258

Minimize Menorrhagia in Women With Type 1 Von Willebrand Disease - Full Text View - ClinicalTrials.govMinimize Menorrhagia in Women With Type 1 Von Willebrand Disease - Full Text View - ClinicalTrials.gov

Antifibrinolytic Agents. Fibrin Modulating Agents. Molecular Mechanisms of Pharmacological Action. Hemostatics. Coagulants. ... Willingness to avoid aspirin (ASA) and nonsteroidal anti-inflammatory agents (NSAIDS) during the study. ... and any drugs or hemostatic agents taken. ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT02606045?term=Inherited+Bleeding+Disorder&

Vitamin K Supplementation in Patients on Hemodialysis - Full Text View - ClinicalTrials.govVitamin K Supplementation in Patients on Hemodialysis - Full Text View - ClinicalTrials.gov

Antifibrinolytic Agents. Fibrin Modulating Agents. Molecular Mechanisms of Pharmacological Action. Hemostatics. Coagulants. ... Major bleeding events and risk stratification of antithrombotic agents in hemodialysis: results from the DOPPS. Kidney Int. ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT02324686

March 5, 2019 - Volume 132 - Issue 5 : Chinese Medical JournalMarch 5, 2019 - Volume 132 - Issue 5 : Chinese Medical Journal

Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis. Yuan, Lei; Zeng, Yan; Chen, Zhong- ...
more infohttps://journals.lww.com/cmj/toc/2019/03050

Epileptic Seizures Following Cortical Application of Fibrin Sealants Containing Tranexamic Acid in Rats | SpringerLinkEpileptic Seizures Following Cortical Application of Fibrin Sealants Containing Tranexamic Acid in Rats | SpringerLink

Keywords: Epilepsy; antifibrinolytic agent; tissue adhesive. This is a preview of subscription content, log in to check access. ...
more infohttps://link.springer.com/article/10.1007%2Fs701-002-8275-z

Hemophilia Treatment Drugs Market Size, Share, Sales, Growth, Trends, Demand and Forecast to 2021 | HealthcareHemophilia Treatment Drugs Market Size, Share, Sales, Growth, Trends, Demand and Forecast to 2021 | Healthcare

Antifibrinolytic Agents. This section of the market research report includes analysis of major raw materials suppliers, ... "He Belongs in Leavenworth Prison": Former FBI Assistant Director Calls for Clinton Operative and Disgraced FBI Agent Peter ...
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Doppler sonography enhances rtPA-induced fibrinolysis in an in vitro clot model of spontaneous intracerebral hemorrhages.Doppler sonography enhances rtPA-induced fibrinolysis in an in vitro clot model of spontaneous intracerebral hemorrhages.

Antifibrinolytic Agents. Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins ... If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2263118/Doppler-sonography-enhances-rtPA-induced-fibrinolysis-in-an-in-vitro-clot-model.html

Antiplatelet Agents in Acute Coronary SyndromesAntiplatelet Agents in Acute Coronary Syndromes

Keywords Acute Coronary Syndrome; Myocardial Infarction; Platelet Aggregation; Blood Platelets Inhibitors; Antifibrinolytic ... Unlike thienopyridine agents, ticagrelor is not a prodrug and acts immediately after oral absorption. It exhibits, thus, a ... The pharmacological characteristics of these agents are summarized in Table 2.. Table 2 Pharmacological properties of ... The evidence that has validated the use of glycoprotein (GPIs) IIb-IIIa inhibitors in PCI, given the ability of these agents to ...
more infohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-56472017000500442&lng=en&nrm=iso&tlng=en

Blood conservation strategies to reduce the need for red blood cell transfusion in critically ill patients | CMAJBlood conservation strategies to reduce the need for red blood cell transfusion in critically ill patients | CMAJ

Antifibrinolytic agents. Antifibrinolytic agents are general hemostatic agents that inhibit the breakdown of blood clots. They ... They include the use of hemostatic agents (e.g., antifibrinolytic agents, desmopressin and recombinant activated factor VII [ ... Trauma patients may also benefit from the use of antifibrinolytic agents. Two trials19,20 evaluated the use of aprotinin in ... On the basis of these studies, the use of antifibrinolytic agents may be useful for controlling bleeding in selected critically ...
more infohttp://www.cmaj.ca/content/178/1/49.full

Childhood Vascular Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] | HealthLink BCChildhood Vascular Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] | HealthLink BC

Antifibrinolytic agent therapy.. *Chemotherapy, including vincristine, cyclophosphamide, actinomycin, and methotrexate used ... Biologic agents that inhibit angiogenesis have shown activity in adults with angiosarcoma.[16,27] ... Further studies are needed to assess differences between the toxicities of these agents and the toxicities of propranolol. ... No current studies are investigating the effectiveness of using combination therapy with these two agents. ...
more infohttps://www.healthlinkbc.ca/health-topics/ncicdr0000774170

Drug - Trapic MF 250mg/500mg (10 Tablet Tablet   ) (Tranexamic Acid) Price ListDrug - Trapic MF 250mg/500mg (10 Tablet Tablet ) (Tranexamic Acid) Price List

This medication is an antifibrinolytic agent, used for reduction or prevention of excessive menstrual bleeding. It is also used ...
more infohttp://www.medindia.net/drug-price/tranexamic-acid/trapic-mf.htm
  • This work from the laboratory of S. Paul Bajaj, Ph.D., demonstrates that unique antifibrinolytic agents can be derived from tissue factor pathway inhibitor-2 (TFPI-2). (bio-medicine.org)
  • The increased conceptual understanding of receptors, agonists, and antagonists of the pathophysiological cascades involved in this process has allowed the development of new drugs and refinement of the current therapy, demanding a complete knowledge of the arsenal of antiplatelet agents with respect to their indication, dosage, moment of administration, and duration of treatment. (scielo.br)
  • Strategies to reduce blood loss associated with diagnostic testing and the use of hemostatic agents and erythropoietin result in higher hemoglobin levels, but they have not been shown to reduce the need for blood transfusions or to improve clinical outcomes. (cmaj.ca)
  • Omeros is developing a series of novel antifibrinolytic agents for the control of blood loss during surgery or resulting from trauma. (bio-medicine.org)
  • This agent increases levels of C4 component of complement and reduces attacks associated with angioedema. (medscape.com)