Drugs used to prevent NAUSEA or VOMITING.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Emesis and queasiness occurring after anesthesia.
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
A dopamine D2 antagonist that is used as an antiemetic.
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
Vomiting caused by expectation of discomfort or unpleasantness.
A type of massage in which finger pressure on specific body sites is used to promote healing, relieve fatigue, etc. Although the anatomical locations are the same as the ACUPUNCTURE POINTS used in ACUPUNCTURE THERAPY (hence acu-), no needle or other acupuncture technique is employed in acupressure. (From Random House Unabridged Dictionary, 2d ed). Shiatsu is a modern outgrowth that focuses more on prevention than healing.
Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
Designated locations along nerves or organ meridians for inserting acupuncture needles.
An anti-inflammatory 9-fluoro-glucocorticoid.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Pain during the period after surgery.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (1/720)

Dexamethasone (20 mg) or its equivalent in combination with 5-HT3 antagonists appears to be the gold-standard dose for antiemetic prophylaxis. Additional to concerns about the use of corticosteroids with respect to enhanced tumour growth or impaired killing of the tumour cells, there is evidence that high-dosage dexamethasone impairs the control of delayed nausea and emesis, whereas lower doses appear more beneficial. To come closer to the most adequate dose, we started a prospective, single-blind, randomized trial investigating additional dosage of 8 or 20 mg dexamethasone to tropisetron (Navoban), a 5-HT3 receptor antagonist, in cis-platinum-containing chemotherapy. After an interim analysis of 121 courses of chemotherapy in 69 patients, we have been unable to detect major differences between both treatment alternatives. High-dose dexamethasone (20 mg) had no advantage over medium-dose dexamethasone with respect to objective and subjective parameters of acute and delayed nausea and vomiting. In relation to concerns about the use of corticosteroids in non-haematological cancer chemotherapy, we suggest that 8 mg or its equivalent should be used in combination with 5-HT3 antagonists until further research proves otherwise.  (+info)

Antiemetic efficacy of granisetron plus dexamethasone in bone marrow transplant patients receiving chemotherapy and total body irradiation. (2/720)

Few trials exist regarding the antiemetic efficacy of granisetron in bone marrow transplant (BMT) recipients conditioned with high-dose chemotherapy and total body irradiation (TBI). In this single-center, open-label, prospective, trial, the antiemetic efficacy and safety of granisetron plus dexamethasone were evaluated in 26 patients conditioned with cyclophosphamide-containing regimens (the majority receiving 60 mg/kg per day on 2 consecutive days), and TBI (12 Gy divided over 4 days). Daily intravenous doses of granisetron 1 mg plus dexamethasone 10 mg were given 30 min prior to chemotherapy or radiation, and continued for 24 h after the last conditioning treatment for a median of 6 days (range 3-9). Emetic control was defined by the number of emetic episodes occurring within a 24 h period, or the requirement for rescue medication for nausea or vomiting. A total of 25 patients completed 186 evaluable treatment days. Response (emetic control by treatment days) was complete in 50% of patients, major in 48%, minor in 2%, and there were no failures. Adverse effects were minor, with diarrhea (15%), headache (14%), and constipation (11%) reported most often. Based on these results, the antiemetic regimen of granisetron plus dexamethasone appears effective and well tolerated during BMT conditioning with high-dose cyclophosphamide and TBI.  (+info)

Antiemetic efficacy of granisetron: a randomized crossover study in patients receiving cisplatin-containing intraarterial chemotherapy. (3/720)

BACKGROUND: Cisplatin (CDDP) is one of the most active chemotherapeutic agents but is among the most emetogenic drugs. The emetic side-effects of CDDP-containing intraarterial chemotherapy have not been evaluated in a prospective randomized trial and the efficacy of serotonin antagonists in preventing the emesis associated with this method of CDDP administration has not been assessed. METHODS: CDDP 50 mg/m2 and methotrexate 30 mg/m2 were administered every 3 weeks through intraarterial catheters placed in the bilateral internal iliac arteries. Patients were classified into two groups: granisetron treatment group (group G) and no treatment group (group NG) with the first course of chemotherapy, crossing over with the second course. The patients in group G received granisetron 40 micrograms/kg by intravenous infusion. RESULTS: Although intraarterial CDDP administration produced less emesis than intravenous CDDP administration, at the same concentration, gastrointestinal toxicity is still the most unpleasant side-effect for patients. Granisetron administration significantly reduced nausea and vomiting during the acute emetic phase (an evaluation of treatment as very effective and effective was made in 89% in group G and 33% in group NG (P < 0.001). Complete control of emesis was achieved in 68 and 18% of patients in groups G and NG, respectively (P < 0.0001). CONCLUSION: A single prophylactic infusion of granisetron was effective in preventing the nausea and vomiting associated with intraarterial CDDP-containing therapy.  (+info)

Tropisetron (Navoban) in the control of nausea and vomiting induced by combined cancer chemotherapy in children. (4/720)

BACKGROUND: We aimed to assess the potency and efficacy of tropisetron, a 5-HT3 receptor antagonist, in the prevention of nausea and emesis observed in the pediatric patient population taking various chemotherapy protocols. METHODS: Tropisetron (Navoban) was given to 100 children (62 boys and 38 girls aged 6 months to 15 years) with various malignancies. Patients received tropisetron during one or more courses of emetogenic chemotherapy for a total of 350 courses administered intravenously or intravenously and intrathecally. Tropisetron (0.2 mg/kg/day, maximum: 5 mg/day) was administered as a single intravenous dose slowly, before the start of chemotherapy on day 1 and intravenously or by mouth on subsequent days (median treatment duration: 5 days). RESULTS: The patients receiving cytotoxic chemotherapy had a 70% complete response rate and a 24% partial response rate during the first 24 h period of the first course. We observed headache (five courses), diarrhea (three courses) and loss of appetite (one course) as side-effects (2.5%). CONCLUSION: Tropisetron is safe, effective, easy to use, has no serious side-effects and can be recommended for pediatric patients. The efficacy of tropisetron may be enhanced by the addition of corticosteroids in patients receiving highly emetogenic cancer chemotherapy.  (+info)

Postoperative analgesia and vomiting, with special reference to day-case surgery: a systematic review. (5/720)

BACKGROUND: Day-case surgery is of great value to patients and the health service. It enables many more patients to be treated properly, and faster than before. Newer, less invasive, operative techniques will allow many more procedures to be carried out. There are many elements to successful day-case surgery. Two key components are the effectiveness of the control of pain after the operation, and the effectiveness of measures to minimise postoperative nausea and vomiting. OBJECTIVES: To enable those caring for patients undergoing day-case surgery to make the best choices for their patients and the health service, this review sought the highest quality evidence on: (1) the effectiveness of the control of pain after an operation; (2) the effectiveness of measures to minimise postoperative nausea and vomiting. METHODS: Full details of the search strategy are presented in the report. RESULTS - ANALGESIA: The systematic reviews of the literature explored whether different interventions work and, if they do work, how well they work. A number of conclusions can be drawn. RESULTS-ANALGESIA, INEFFECTIVE INTERVENTIONS: There is good evidence that some interventions are ineffective. They include: (1) transcutaneous electrical nerve stimulation in acute postoperative pain; (2) the use of local injections of opioids at sites other than the knee joint; (3) the use of dihydrocodeine, 30 mg, in acute postoperative pain (it is no better than placebo). RESULTS-ANALGESIA, INTERVENTIONS OF DOUBTFUL VALUE: Some interventions may be effective but the size of the effect or the complication of undertaking them confers no measurable benefit over conventional methods. Such interventions include: (1) injecting morphine into the knee joint after surgery: there is a small analgesic benefit which may last for up to 24 hours but there is no clear evidence that the size of the benefit is of any clinical value; (2) manoeuvres to try and anticipate pain by using pre-emptive analgesia; these are no more effective than standard methods; (3) administering non-steroidal anti-inflammatory drugs (NSAIDs) by injection or per rectum in patients who can swallow; this appears to be no more effective than giving NSAIDs by mouth and, indeed, may do more harm than good; (4) administering codeine in single doses; this has poor analgesic efficacy. RESULTS-ANALGESIA, INTERVENTIONS OF PROVEN VALUE: These include a number of oral analgesics including (at standard doses): (1) dextropropoxyphene; (2) tramadol; (3) paracetamol; (4) ibuprofen; (5) diclofenac. Diclofenac and ibuprofen at standard doses give analgesia equivalent to that obtained with 10 mg of intramuscular morphine. Each will provide at least 50% pain relief from a single oral dose in patients with moderate or severe postoperative pain. Paracetamol and codeine combinations also appear to be highly effective, although there is little information on the standard doses used in the UK. The relative effectiveness of these analgesics is compared in an effectiveness 'ladder' which can inform prescribers making choices for individual patients, or planning day-case surgery. Dose-response relationships show that higher doses of ibuprofen may be particularly effective. Topical NSAIDs (applied to the skin) are effective in minor injuries and chronic pain but there is no obvious role for them in day-case surgery. RESULTS-POSTOPERATIVE NAUSEA AND VOMITING: The proportion of patients who may feel nauseated or vomit after surgery is very variable, despite similar operations and anaesthetic techniques. Systematic review can still lead to clear estimations of effectiveness of interventions. Whichever anti-emetic is used, the choice is often between prophylactic use (trying to prevent anyone vomiting) and treating those people who do feel nauseated or who may vomit. Systematic reviews of a number of different anti-emetics show clearly that none of the anti-emetics is sufficiently effective to be used for prophylaxis. (ABSTRACT TRUNCATE  (+info)

Prophylactic antiemetic therapy with a combination of granisetron and dexamethasone in patients undergoing middle ear surgery. (6/720)

We have compared the efficacy of granisetron in combination with dexamethasone with each drug alone in the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double-blind study, 120 patients (85 females) received granisetron 3 mg, dexamethasone 8 mg or granisetron 3 mg with dexamethasone 8 mg i.v. (n = 40 in each group), immediately before induction of anaesthesia. A standardized general anaesthetic technique was used. A complete response, defined as no PONV and no need for another rescue antiemetic during the first 3 h after anaesthesia, was recorded in 83%, 50% and 98% of patients who had received granisetron, dexamethasone and granisetron-dexamethasone, respectively. The corresponding incidences during the next 21 h after anaesthesia were 80%, 55% and 98% (P < 0.05; overall Fisher's exact probability test). In summary, prophylactic use of combined granisetron and dexamethasone was more effective than each antiemetic alone for the prevention of PONV after middle ear surgery.  (+info)

Nausea during pregnancy and congenital heart defects: a population-based case-control study. (7/720)

The authors investigated the possible association between a mother's nausea during pregnancy and her child's risk for a congenital heart defect using data from the population-based Atlanta Birth Defects Case-Control Study conducted in 1982-1983. Case infants (n = 998) had nonsyndromic congenital heart defects and control infants (n = 3,029) had no congenital defects. Nausea during pregnancy (NP) was graded in eight levels of "severity" based on its onset, frequency, and duration. Level 1, the most severe NP, was associated with a lower risk for a congenital heart defect in the child (odds ratio (OR) = 0.81, 95% confidence interval (CI) 0.67-0.99) compared with no nausea. The lower risk tended to disappear with less severe levels of nausea, and the trend was statistically significant. Overall, early NP (levels 1 to 4 combined) with use of antinausea medication, particularly Bendectin (doxylamine, dicyclomine (dropped from the formulation in 1976), pyridoxine (vitamin B6)), was associated with a lower risk for congenital heart defects compared with: 1) absence of nausea (OR = 0.67, 95% CI 0.50-0.92), and 2) nausea without medication use (OR = 0.70, 95% CI 0.50-0.94). The results suggest that pregnancy hormones and factors or, alternatively, a component of Bendectin (most probably pyridoxine) may be important for normal heart development. These findings outline potential areas for future research on and prevention of congenital heart defects.  (+info)

Granisetron (Kytril) suppresses methotrexate-induced nausea and vomiting among patients with inflammatory arthritis and is superior to prochlorperazine (Stemetil). (8/720)

OBJECTIVE: Methotrexate (MTX) is an increasingly popular anti-rheumatic drug with its usefulness limited by toxicity, most commonly gastrointestinal (GI). The aim of the study was to study the effectiveness of the 5-HT3 receptor antagonist granisetron (GR) in the therapy of MTX-induced nausea. METHODS: A single-blind 8 week pilot study with random allocation to either GR 1 mg or prochlorperazine (Stemetil; PCh) 10 mg was undertaken in 13 patients who were taking or had taken MTX for either rheumatoid arthritis (10) or psoriatic arthritis (3). RESULTS: One in six patients treated with PCh completed the 8 week study compared to 7/7 treated with GR. After switching of symptomatic patients, 11 completed the study on GR and median improvement was by two grades (P < 0.001) with a significantly better visual analogue scale score for patient satisfaction compared to PCh. CONCLUSION: Treatment with GR may be useful in establishing and maintaining some patients on MTX where GI toxicity would have precluded such therapy.  (+info)

TY - JOUR. T1 - The cost of antiemetic therapy for chemotherapy-induced nausea and vomiting in patients receiving platinum-containing regimens in daily practice in Japan. T2 - A retrospective study. AU - Hamada, Shota. AU - Hinotsu, Shiro. AU - Hori, Katsuhito. AU - Furuse, Hiroshi. AU - Oikawa, Takehiro. AU - Kawakami, Junichi. AU - Ozono, Seiichiro. AU - Akaza, Hideyuki. AU - Kawakami, Koji. PY - 2012/4. Y1 - 2012/4. N2 - Purpose The objective of this study was to estimate the cost of antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in daily practice in Japan. Methods This was a retrospective observational study using medical records. Eligible patients were those with bladder or testicular cancer receiving platinum-containing highly emetogenic chemotherapy. The incidence of CINV on days 1-5 in single-day chemotherapy and on days 1-9 in multiple-day chemotherapy, and the costs of antiemetic therapy directly associated with the administration of antiemetics were estimated. ...
Despite significant progress in the prevention of chemotherapy-induced nausea and vomiting (CINV) with the introduction of new antiemetic agents, 30–50% of patients receiving moderately or highly emetogenic chemotherapy (MEC or HEC) and guideline directed prophylactic antiemetics develop breakthrough CINV. International guidelines recommend the treatment of breakthrough CINV with an agent from a drug class that was not used in the prophylactic antiemetic regimen and recommend using the breakthrough medication continuously rather than using it on an as needed basis. There have been very few studies on the treatment of breakthrough CINV. A recent double-blind, randomized, phase III study suggested that olanzapine may be an effective agent for the treatment of breakthrough CINV. Refractory CINV occurs when patients develop CINV during subsequent cycles of chemotherapy when antiemetic prophylaxis has not been successful in controlling CINV in earlier cycles. Patients who develop refractory CINV
Olanzapine is frequently used off-label as an adjunct antiemetic in clinical oncology settings. North American oncology guidelines recommend it as salvage therapy and as add-on to the standard triple regimen; some suggest it may also be effective as an initial triple therapy (olanzapine replacing the NK-1 antagonist) based on phase II and III trials.. This prospective, multi-center, open-label study aims to evaluate the feasibility of a large scale randomised controlled trial to compare the effectiveness and tolerability of 5mg orally once daily olanzapine in triple antiemetic therapy versus the standard treatment of aprepitant + ondansetron + dexamethasone in treatment-naive patients receiving the first cycle of a highly emetogenic chemotherapy. Secondary outcomes include effectiveness, tolerability and quality of life assessments. Effectiveness will be measured with complete response and complete remission rates in each treatment arms. Tolerability and patient quality of life will be evaluated ...
Background Chemotherapy-induced nausea and vomiting (CINV) is one of the most problematic symptoms experienced by patients undergoing cancer treatments. Triplet therapy with PALO, APR, and DEX, is a guideline-recommended antiemetic prophylaxis for highly emetogenic chemotherapy (HEC). However, the efficacy and safety of this therapy for lung cancer patients has not yet been well investigated.. Methods Chemotherapy naïve lung cancer patients scheduled to receive HEC were enrolled in this study. The eligible patients were pretreated with the triplet therapy (PALO 0.75 mg day 1, APR 125 mg day 1 and 80 mg day 2-3, DEX 9.9 mg day 1 and 8 mg day 2-4) before receiving HEC. The efficacy and safety of these substances were assessed during an observation period starting from the administration of HEC to 120 hours. A questionnaire diary documented patients complaints. The primary endpoint was the proportion of the patients who did not experience emesis or rescue antiemetic (Complete Response rate; CR ...
Frieda Clinton and colleagues present a study at one childrens cancer centre into the use and effectiveness of anti-emetics for patients receiving chemotherapy An audit was conducted of the management of chemotherapy-induced nausea and vomiting in children and young people in the national Irish paediatric cancer unit. Over three months, the anti-emetic medication and the incidence of nausea and vomiting in 50 consecutive patient episodes were recorded among 25 children receiving chemotherapy for diverse malignancies. Anti-emetic prescription was found to be unrelated to the emetogenic potential of the chemotherapy received, so that effectiveness varied. Dexamethasone was used in only one case. Twenty children did not take any anti-emetics following discharge, although 11 experienced delayed vomiting. evidence-based guidelines were established and now include anti-emetic prescription that is proportional to the emetogenic potential of the chemotherapeutic regimen. It is also recommended that ...
Abstract. Although current antiemetic agents, either singularly or in combination, have had substantial positive effects on controlling chemotherapy-induced nausea and vomiting (CINV), there are still concerns regarding how well advanced practitioners can effectively manage delayed nausea and vomiting with the current array of modalities. A review of antiemetic development and research in the past has formed the basis for current standard-of-care antiemetics. The same will hold true for new antiemetics and improvements in antiemetic and other therapy guidelines for CINV. New agents are undergoing study, and other ways to view success and efficacy in quantitative and qualitative studies for CINV are being considered. ...
Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics Megan Brafford May,1 Ashley E Glode2 1Department of Pharmacy, Baptist Health Lexington, Lexington, KY, USA; 2Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Abstract: Chemotherapy-induced nausea and vomiting (CINV) is one of the most common symptoms feared by patients, but may be prevented or lessened with appropriate medications. Several antiemetic options exist to manage CINV. Corticosteroids, serotonin receptor antagonists, and neurokinin receptor antagonists are the classes most commonly used in the prevention of CINV. There are many alternative drug classes utilized for the prevention and management of CINV such as antihistamines, benzodiazepines, anticonvulsants, cannabinoids, and dopamine receptor antagonists. Medications belonging to these classes generally have lower efficacy and are associated with more
TY - JOUR. T1 - A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting. AU - Ho, Ching Liang. AU - Su, Wu Chou. AU - Hsieh, Ruey Kuen. AU - Lin, Zhong Zhe. AU - Chao, Tsu Yi. PY - 2009/12/20. Y1 - 2009/12/20. N2 - Objective: To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting. Methods: Cancer patients scheduled to receive chemotherapy containing either of the four drugs (cisplatin, doxorubicin, epirubicin or oxaliplatin) were enrolled. They were randomized to receive intravenous ramosetron 0.3 mg plus dexamethasone 20 mg or granisetron 3 mg plus dexamethasone 20 mg 30 min before chemotherapy on day 1. The primary efficacy parameter is complete response rate, which was defined by the proportion of patients without vomiting and no requirement for rescue drugs within ...
TY - JOUR. T1 - Combined data from two phase III trials of the NK1 antagonist aprepitant plus a 5HT3 antagonist and a corticosteroid for prevention of chemotherapy-induced nausea and vomiting. T2 - Effect of gender on treatment response. AU - Hesketh, P. J.. AU - Grunberg, S. M.. AU - Herrstedt, J.. AU - De Wit, R.. AU - Gralla, Richard J.. AU - Carides, A. D.. AU - Taylor, A.. AU - Evans, J. K.. AU - Horgan, K. J.. PY - 2006/4. Y1 - 2006/4. N2 - Goals of work: Prevention of chemotherapy-induced nausea and vomiting (CINV) with standard antiemetics has been more difficult to achieve in female patients. Data from two phase III trials of the NK1 antagonist aprepitant were assessed for potential effect of gender on treatment response. Patients and methods: 1,044 patients receiving cisplatin (≥70 mg/m 2) were randomly assigned to control regimen [ondansetron (O) 32 mg i.v. and dexamethasone (D) 20 mg p.o. on day 1; D 8 mg twice daily on days 2-4] or aprepitant (A) regimen (A 125 mg p.o. plus O 32 ...
Abstract: Chemotherapy-induced nausea and vomiting (CINV) is one of the most common symptoms feared by patients, but may be prevented or lessened with appr
Efficacy and safety were evaluated in 152 aprepitant and 150 control patients. The proportion of patients experiencing no emetic episodes was higher in the aprepitant regimen vs the control regimen during both acute (71.1% vs 53.3%) and delayed (55.3% vs 28.0%) phases. The median time to first vomiting (overall) was significantly longer for aprepitant vs control (94.5 vs 26.0 hours; P < 0.0001). The proportion of patients not requiring rescue medication use was higher for aprepitant vs control (66.4% vs 48.7%), and the time to first rescue medication use was longer for aprepitant vs control (P = 0.0024). Adverse events were similar between regimens and consistent with those in patients undergoing chemo. ...
The Antiemetics market provides detailed market segment level data on the international market. The Antiemetics market report addresses forecast and growth
Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials
Oral: Moderately emetogenic chemotherapy or radiotherapy: 8 mg 1-2 hours before treatment, then 8 mg every 12 hours for up to 5 days. Severely emetogenic chemotherapy: 8 mg every 12 hours for up to 5 days. Children: 4 mg every 12 hours for up to 5 days. Prevention of postoperative nausea and vomiting: 16 mg 1 hour before anaesthesia followed by 8 mg at 8 hour intervals for 2 further doses.Oral Solution: Prevention of chemotherapy induced nausea & vomiting: Adult: The recommended adult oral dosage is Emiston (Ondasetron) 10 ml oral solution thrice daily in highly emetogenic chemotherapy. In case of moderately emetogenic chemotherapy the oral dose is 10 ml Emiston (Ondasetron) given twice daily. Pediatric Patient: For Pediatric patients 4 through 11 years of age should be given 5 ml oral solution 3 times a day for 1 to 2 days after completion of chemotherapy. Radiotherapy induce nausea and vomiting: The recommended adult oral dosage is Emiston (Ondasetron) 10 ml oral solution thrice daily. Post ...
Abstract Xenobiotic cannabinoid CB1/CB2-receptor agonists appear to possess broad-spectrum antiemetic activity since they prevent vomiting produced by a...
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to center.. Patients receive their scheduled chemotherapy regimen containing doxorubicin and their scheduled oral 5 hydroxytryptamine 3 receptor antagonist antiemetic (ondansetron, granisetron, tropisetron, or dolasetron mesylate) combined with dexamethasone on day 1.. Patients are then randomized to 1 of 3 antiemetic arms.. ...
Scott E Mimms, MD, Anna Ibele, MD, Dan McKenna, MD, Lori Blythe, RN, Selzer Don, MD, John Ditslear III, MD, Margaret Inman, MD, Chris Evanson, MD, Samer G Mattar, MD. Clarian North Medical Center. BACKGROUND: Post-operative nausea and vomiting (PONV) is a common complication following LRYGB which can lead to a longer hospital stay. Anti-emetics currently used are not completely effective. Aprepitant, a new class antiemetic, has been shown to reduce the incidence and severity of PONV as well as the length of stay in patients undergoing abdominal and orthopedic surgeries. In combination with corticosteroids and ondansetron, it has been used with good success in reducing the incidence of chemotherapy-induced nausea and vomiting. This study aims to evaluate the effectiveness of Emend ®, in combination with corticosteroids, ondansetron, and metoclopramide, in decreasing the length of stay (LOS) in LRYGB. We selected LOS as a surrogate for serious postoperative nausea and/or dehydration ...
The best way to treat nausea and vomiting is to prevent it from occurring in the first place. Many new and improved medicines for controlling nausea and vomiting, called antiemetics, have been developed over the last several years. These drugs block the signal in the brain that causes nausea and vomiting. As a result of widespread use of antiemetics, nausea and/or vomiting is not as severe and does not occur as frequently as in the past. There are many different kinds of antiemetics and you may need to try more than one before finding a prescription that works for you.. 5-HT3 inhibitors: The 5HT-3 Inhibitors are the most effective antiemetics and constitute the single greatest advance in the management of nausea and vomiting in patients with cancer. These drugs are designed to block one or more of the signals that cause nausea and vomiting. The most sensitive signal during the first 24 hours after chemotherapy appears to be 5-HT3. Blocking the 5-HT3 signal is one approach to preventing acute ...
Patient satisfaction with antiemetics correlated with QOL. Pharmacoecon. Outcomes News 299, 10 (2001). https://doi.org/10.1007/BF03269164. Download ...
[100% Customization with 12.5% Discount] [Pre-Book Price $3,950] Antiemetics Market (Type, Application and Geography) - Global Industry Analysis, Growth, Trends, Opportunities, Size, Share and Forecast, 2014 - 2020 , Overview, Market Analysis, Future Demand, Leaders, Company Profiles, Research Insights, Segmentation, Adoption, Sales and Forecast
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According to the latest market study released by Technavio, the global antiemetic drugs marketis expected to grow at a CAGR of more than 6% during the forecast period. This Smart News
Abstract. Postoperative nausea and vomiting (PONV) is one of the most common and distressing adverse events after laparoscopic cholecystectomy (LC). A meta-analysis of randomized clinical trials (RCTs) was performed to determine the efficacy and safety of dexamethasone combined with other antiemetic in the prevention of PONV in patients undergoing LC. A systematic literature search was conducted to identify all relevant RCTs. The primary outcome was PONV in the early period (0-3 hours, 0-4 hours, or 0-6 hours), late period (>6 hours), and the overall period (0-24 hours). Nine RCTs with a total of 1089 patients were included in the analysis. Pooled analysis showed that dexamethasone combined with other antiemetics provided significantly better prophylaxis than single antiemetics in the early period [odds ratio (OR): 0.34, 95% confidence interval (CI): 0.21-0.55, p < 0.001], late period (OR: 0.35, 95% CI: 0.22-0.57, p < 0.001), and the overall period (OR: 0.36, 95% CI: 0.27-0.49, p < 0.001). ...
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors ...
This study will investigate the efficacy and tolerability of aprepitant as add-on therapy to dexamethasone + serotonin-3 receptor antagonists (ondansetron,
The use of chemotherapeutic agents for cancer treatment has long been a common approach in treating veterinary patients. Access to more sophisticated diagnostics and treatments have increased over time, and more pet owners are willing to seek advanced care when pets are diagnosed with cancer. Clinicians now have a broader range of options to offer from conventional chemotherapy to radiation therapy to targeted approaches such as the use of tyrosine kinase inhibitors.
1. The first co-primary objective is to explore the safety of an antiemetic regimen consisting of Akynzeo and dexamethasone during five weeks of fractionated (5
Aprepitant Oral capsule, Aprepitant Oral capsuleWhat is this medicine?APREPITANT (ap RE pi tant) is used with other medicines to prevent nausea and vomitin
This meta-analysis is open to some biases, and they all have the potential to overestimate the efficacy and to underestimate the harm of cannabinoids. The trials we included were of acceptable quality according to the Oxford quality scale, with 25 of 30 trials scoring 3 or 4. In 70% of trials an adequate method of blinding was described. Most crossover trials used a double dummy design. Cannabinoids were given as tablets or intramuscular injection, so any psychological effect of smoking a joint was not a factor. However, cannabinoids showed specific adverse effects that control treatments did not, and their incidence was high. In one trial of oral nabilone, many patients identified which drug they received because of the adverse effects experienced.59 In a series of 100 blinded dronabinol and placebo treatments, nurses correctly identified the active treatment in 85% and patients in 95%; seven of the 10 errors were made by patients on the first drug trial of the study.63 We must therefore assume ...
This meta-analysis is open to some biases, and they all have the potential to overestimate the efficacy and to underestimate the harm of cannabinoids. The trials we included were of acceptable quality according to the Oxford quality scale, with 25 of 30 trials scoring 3 or 4. In 70% of trials an adequate method of blinding was described. Most crossover trials used a double dummy design. Cannabinoids were given as tablets or intramuscular injection, so any psychological effect of smoking a joint was not a factor. However, cannabinoids showed specific adverse effects that control treatments did not, and their incidence was high. In one trial of oral nabilone, many patients identified which drug they received because of the adverse effects experienced.59 In a series of 100 blinded dronabinol and placebo treatments, nurses correctly identified the active treatment in 85% and patients in 95%; seven of the 10 errors were made by patients on the first drug trial of the study.63 We must therefore assume ...
An extra look for of the first literature For the reason that critique by Whiting et al. (2015) did not identify any further scientific studies. The key literature was then searched in an effort to obtain experiments of cannabinoids in comparison to the more greatly utilised antiemetics. One trial done in 2007 investigated a cannabinoid therapy as compared to the current generation of serotonin antagonist antiemetics, in contrast to the dopamine D2 receptor antagonists Employed in the sooner trials ...
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Report DetailsTreatments for nausea and vomiting - explore business trends, R&D, and revenue forecastsWhats the future of treating nausea and vomiting? Fo ...
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CAS Registry Number: [654671-77-9]. Molecular Formula: C23H21F7N4O3. Molecular Weight: 534.53. Method of Analysis: USP. prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV). ...
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In continuation of my update on Varubi (rolapitant) Tesaro, Inc. an oncology-focused biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has approved Varubi (rolapitant) IV in combination with other antiemetic agents in adults for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including, but not limited to, […]. ...
Despite the widespread availability of antiemetic regimens, between 30% and 50% of patients receiving chemotherapy experience treatment-related nausea and/or vomiting.
A 5-year-old girl is brought is by her mother for two days of nausea, vomiting, diarrhea, and fever. She has multiple sick contacts at home with the same. She has no abdominal pain, change in behavior, or rash. The girl is unable to tolerate a PO trial in the ED after antiemetics. Her VS T 39.3 C HR 150 RR 22 BP 98/60. She is well appearing but tired and moderately volume depleted on exam. Her exam is otherwise normal ...
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Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. The Global CINV Drugs Market to GROW at a CAGR of 5.41% during the period 2017-2021.. Chemotherapy-induced Nausea and Vomiting Drugs Market research report provides granular analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Chemotherapy-induced Nausea and Vomiting Drugs Market report 2016-2022 focuses on the major drivers and restraints for the key players. The Chemotherapy-induced Nausea and Vomiting Drugs Market research report is a professional and in-depth study on the current state of Chemotherapy-induced Nausea and Vomiting Drugs Market Warming Devices Industry.. Browse more detail information about Chemotherapy-induced Nausea and Vomiting Drugs Market Report at: http://www.absolutereports.com/global-chemotherapy-induced-nausea-and-vomiting-drugs-market-2017-2021-10533708 The launch of extended half-life drugs in the market is expected to substantially ...
Purpose: To assess the comparative antiemetic efficacy of single-dose intravenous (IV) dolasetron mesylate and ondansetron in preventing cisplatin-induced nausea and vomiting. Patients and Methods: Cancer patients (n = 609) receiving first-course cisplatin chemotherapy were randomized to one of three treatments: 1.8 or 2.4 mg/kg dolasetron mesylate salt (equivalent to 1.3 and 1.8 mg/kg dolasetron base, respectively) or 32 mg ondansetron. Each treatment was infused over 15 minutes, 30 minutes before cisplatin administration. Patients were stratified to cisplatin doses of ,greater than or equal to greater than or equal to 70 and less than 91 mg/m(2) (n = 368) or greater than or equal to 91 mg/m(2) (n = 241), administered over less than or equal to 3 hours, protocol-defined efficacy criteria included complete response (zero emetic episodes and no rescue medication), major response (1 to 2 emetic episodes and no rescue medication), and patients report of nausea severity and satisfaction recorded on ...
As part of a three-drug regimen, APF530 (extended-release formulation of granisetron) has become the first 5-HT3 (5-hydroxytryptamine) receptor antagonist to demonstrate superiority over the standard of care for delayed nausea and vomiting after highly emetogenic chemotherapy. According to the results of the MAGIC trial, presented at the 2015 Breast Cancer Symposium, APF530, administered with fosaprepitant (Emend) and dexamethasone, provided superior complete response in delayed-phase chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy vs a standard-of-care regimen of ondansetron with fosaprepitant plus dexamethasone.1. The APF530 regimen was associated with a clinical benefit over the ondansetron regimen in nausea control, rescue medication use, and patient satisfaction, said Ian D. Schnadig, MD, of Compass Oncology, US Oncology Research, Tualatin, Oregon. It is significant that both arms of the study had a three-drug prophylactic regimen, which has not been ...
TY - JOUR. T1 - Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer. T2 - A prospective registration study by the CINV Study Group of Japan. AU - Baba, Yoshifumi. AU - Baba, Hideo. AU - Yamamoto, Sachiko. AU - Shimada, Hideaki. AU - Shibata, Tomotaka. AU - Miyazaki, Tatsuya. AU - Yoshikawa, Takaki. AU - Nakajima, Yasuaki. AU - Tsuji, Yasushi. AU - Shimokawa, Mototsugu. AU - Kitagawa, Yuko. AU - Aiba, Keisuke. PY - 2017/2/1. Y1 - 2017/2/1. N2 - Chemotherapy is an indispensable therapeutic approach for esophageal cancer. Although chemotherapy-induced nausea and vomiting (CINV) is one of the most crucial adverse events, the current state of CINV in patients with esophageal cancer remains unclear. This multicenter prospective observational study analyzed data for 192 patents with esophageal cancer who underwent moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC). The patients recorded their CINV incidence and ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Antiemetic Drugs Industry is expected to witness growth of international market with respect to advancements and innovations including development history, competitive analysis and regional development forecast.. The report starts with a basic Antiemetic Drugs Industry overview. In this introductory section, the research report incorporates analysis of definitions, classifications, applications and industry chain structure. Besides this, the report also consists of development trends, competitive landscape analysis, and key regions development status.. The Antiemetic Drugs Industry research report shed light on Foremost Regions like:. North America, Europe, China, Japan, Southeast Asia and India. Application likes Chemotherapy, Pregnancy, Motion Sickness, Food Poisoning, Gastroenteritis and Diziness. Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Antiemetic Drugs Industry Research [email protected] ...
A two-year-old child experienced concealed haemorrhage after adenotonsillectomy. In our patient, the absence of vomited or significant gastric blood and the presence of melaena stools may partly be attributed to prophylactic antiemetic treatment with tropisetron. This group of patients has a high incidence of postoperative nausea and vomiting, and antiemetic treatment is important and valuable. Rather than advocating the withholding of prophylactic antiemetic treatment, we suggest that whatever medication and techniques are used, good clinical care is dependent on careful postoperative observation and assessment for an appropriate period of time.
Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial. Dolasetron Mesylate PONV Treatment Study Group.
PURPOSE: To update the 2009 recommendations for the prevention of acute chemotherapy-induced emesis in children. METHODS: We updated the original systematic literature search. Randomized studies were included in the evidence to support this guideline if they were primary studies fully published in full text in English or French; included only children less than 18 years old or, for mixed studies of adults and children, reported the pediatric results separately or the median or mean age was no more than 13 years; evaluated acute chemotherapy-induced nausea and vomiting (CINV) prophylaxis; provided sufficient information to permit determination of the emetogenicity of the antineoplastic therapy administered or the study investigators stated the emetogenicity of the chemotherapy administered; included an implicit or explicit definition of complete acute CINV response; described the antiemetic regimen in full; and reported the complete acute CINV response rate as a proportion ...
ABSTRACT. For evaluation of the antiemetic effects of the drugs animal models (Ferret,cat dog etc) are used. Although good guidelines may be established through the animal experiments, they may not give accurate indication of the antiemetic effect of the antiemetic drugs in patients due to species differences in pharmacokinetic and pharmacodynamic responses. Therefore, Ipecacuanha-induced emesis and flare models are used to predict more accurately the antiemetic effect of the antiemetic drugs. In ipecacuanha-induced emesis model in 10 healthy human volunteers slow intravenous injection of ondanserton -2 ml. (4 mg) was given over 5 minutes.Thirty minutes after inj. ondanserton, 30 ml. oral syrup of tincture ipecac was given with glassful of water. Then the parameters like time, number and duration of emesis were noted over 6 hours period. In flare model in 6 healthy human volunteers Injection Serotonin 0.05 ml of 12.98 µM was given intradermally on the flexor aspect of forearm. Resulting flare ...
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In a phase III study reported in The Lancet Oncology, Schwartzberg et al found that the addition of rolapitant to serotonin (5-HT3) receptor antagonist and dexamethasone treatment significantly improved complete response rates in prevention of chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens.. In this double-blind trial, patients from 170 sites in 23 countries were randomly assigned between March 2012 and September 2013 to receive oral rolapitant 180 mg or placebo 1 to 2 hours before the administration of moderately emetogenic chemotherapy. All patients received oral granisetron 2 mg and oral dexamethasone 20 mg on day 1 (except for those receiving taxanes, who received dexamethasone according to the package insert) and granisetron 2 mg on days 2 and 3. Treatment was given for up to six cycles, with a minimum of 14 days…. The investigators concluded: Rolapitant in combination with a 5-HT3 ...
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Olanzapine, as well as several other neuroleptic drugs, have also has been investigated for the control of CINV.[12] A 2007 study demonstrated Olanzapines successful potential for this use, achieving a complete response in the acute prevention of nausea and vomiting in 100% of patients treated with moderately and highly emetogenic chemotherapy, when used in combination with palonosetron and dexamethasone.[13] Neuroleptic agents are now indicated for rescue treatment and the control of breakthrough nausea and vomiting.[12]. Some studies[14] and patient groups say that the use of cannabinoids derived from cannabis during chemotherapy greatly reduces the associated nausea and vomiting, and enables the patient to eat. Synthesized tetrahydrocannabinol (also one of the main active substances in marijuana) is marketed as Marinol and may be practical for this application. Natural medical cannabis is also used and recommended by some oncologists, though its use is regulated and it is not legal in all ...
Þ rst to demonstrate the antiemetic effects of ondansetron in AGE.[3] Reeves, 2002, also demonstrated the antiemetic properties Review of the literature shows clinicians commonly use and of ondansetron and a decreased hospital admission rate in those prescribe antiemetics for vomiting in children with AGE. A with a serum CO ,15 mEq/L.[14] Ramsook, 2002, was the Þ rst retrospective study of 20,000 children with AGE showed 9% of to compare oral ondansetron to placebo again demonstrating its patients had a prescription Þ lled for an antiemetic. In addition, antiemetic effect and also a decreased need for IVF and hospital 5% of patients under the age of 2 had a prescription Þ lled for admission. SigniÞ cantly higher rates of diarrhea were reported an antiemetic, the most common of which was promethazine in this study related to ondansetron as additional doses of this (Phenergan).[6] A survey of Italian pediatricians reported a 79% medication were given at discharge.[15] In 2006, Freedman ...
In the study (Abstract 9064), 205 patients with a range of tumor types who had not previously received chemotherapy were given standard guideline-recommended drugs to prevent CINV prior to starting highly emetogenic chemotherapy with cisplatin or cyclophosphamide and doxorubicin.. Eighty of the patients developed breakthrough CINV and were randomized in a double-blind manner to receive either olanzapine (10 mg daily for three days) or metoclopramide (10 milligrams three times a day for three days).. Baseline characteristics, including age range (39 to 79 years), percentage of females (about one-fifth), ECOG performance scores (about 31% had scores of 0), and distribution of tumor types (breast, lung, lymphoma, and bladder), were similar between the two groups.. The researchers chose to test olanzapine because physicians treating patients with psychosis made the empirical observation that they appeared to have less nausea and vomiting from other drugs they were on, Navari said.. ...
Chemotherapy-Induced Nausea and Vomiting (CINV) After chemotherapy, you may also be given anti-nausea medications to take at home. Its important to.
ANTIEMETICS are used to prevent vomiting. They are thus related to antinauseant drugs which are used to reduce or prevent the feeling of nausea that very often precedes the physical process of vomiting (emesis). Commonly, the terms are used synonymously, though it is usually an antinauseant action that is being sought. The type of antinauseant drugs used, and the likelihood of success, depends on the mechanism and origin of the nauseous sensation, and there are a number of ways it can be triggered. Motion sickness (travel sickness) can often be prevented by taking antinauseant drugs before travelling, e.g. the antihistamines meclozine and dimenhydrinate, and the anticholinergic hyoscine. Probably all these drugs act as central MUSCARINIC CHOLINOCEPTOR ANTAGONISTS. Similar drugs may be used to treat nausea and some other symptoms of labyrinthine disease (where the vestibular balance mechanisms of the inner ear are disturbed, e.g. in Menieres disease), though other antinauseant drugs may also be ...
Define dimenhydrinate. dimenhydrinate synonyms, dimenhydrinate pronunciation, dimenhydrinate translation, English dictionary definition of dimenhydrinate. n. A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness. n a white slightly soluble bitter-tasting...
TY - JOUR. T1 - Metoclopramide. T2 - Dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. AU - Allen, J. C.. AU - Gralla, R.. AU - Reilly, L.. AU - Kellick, M.. AU - Young, C.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Prior studies in adults have shown that metoclopramide (MCP), when given in high intravenous (IV) doses (2 mg/kg), is a highly effective antiemetic for chemotherapy-induced vomiting. It is well-tolerated in older adults, but younger adults have an increased disposition to acute extrapyramidal reactions (ERPs). Before studying the efficacy of MCP as an antiemetic in children, we first had to establish the safe dose range. We performed a dose-increase MCP toxicity study in children receiving highly emetic chemotherapy such as cisplatin (120 mg/m2) or cyclophosphamide (,900 mg/m2), beginning with a dose of 0.2 mg/kg and increasing the dose in nine steps to 3 mg/kg. MCP was given every two hours for four doses beginning one-half hour before ...
Learn about the drug Antiemetics (Phenothiazines). Includes generic and brand name examples, dosage, how the drug works, why it is used and side effects.
Benign positional vertigo (BPV) is the most common cause of vertigo. Vertigo is an illusion of motion (an illusion is a misperception of a real stimulus) and represents a disorder of the vestibular proprioceptive system.
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Background. In a large cluster-randomized trial on the impact of a prediction model, presenting the calculated risk of postoperative nausea and vomiting (PONV) on-screen (assistive approach) increased the administration of risk-dependent PONV prophylaxis by anaesthetists. This change in therapeutic decision-making did not improve the patient outcome; that is, the incidence ... read more of PONV. The present study aimed to quantify the effects of adding a specific therapeutic recommendation to the predicted risk (directive approach) on PONV prophylaxis decision-making and the incidence of PONV. Methods. A prospective before-after study was conducted in 1483 elective surgical inpatients. The before-period included care-as-usual and the after-period included the directive risk-based (intervention) strategy. Risk-dependent effects on the administered number of prophylactic antiemetics and incidence of PONV were analysed by mixed-effects regression analysis. Results. During the intervention period ...
Postoperative nausea and vomiting (PONV) is one of the most common and distressing complications after surgery. An identification of risk factors associated with PONV would make it easier to select specific patients for effective antiemetic therapy.
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Chemotherapy induced nausea and vomiting (CINV) is a common and extremely unpleasant side effect for children receiving chemotherapy. CINV can lead to complications of treatment and also cause significant emotional and physical distress, disruptions to activities of daily living and influence the quality of life of the patient. The goal of antiemetic therapy is to prevent vomiting and minimise nausea both during and after the administration of chemotherapy. The severity of nausea and vomiting can, to some degree, be predicted by the chemotherapeutic agents being delivered but there is a degree of variation between patients. Antiemetic treatments should be initiated prior to the first dose of chemotherapy for best control of nausea and vomiting, as it can often become difficult to control nausea once the child is actually vomiting. Non-pharmacological measures are also an important consideration and should be implemented in conjunction with pharmacological regimes to allow for the effective ...
We congratulate and thank the Fourth Consensus Conference addressing Guidelines for the Management of Postoperative Nausea and Vomiting (PONV).1 We wholeheartedly agree with its one major change in this iteration of the guideline…that in adults, the panel consensus is now to implement multimodal PONV prophylaxis in patients with 1 or 2 risk factors, in an attempt to reduce risk of inadequate prophylaxis. However, since patients with 0 risk factors still have a 10% PONV risk, and because at least 3 nonsedating off-patent inexpensive antiemetics are easily available with minimal side effect burden, we endorse 2 integrated approaches that differ from those presented by the current or previous Consensus Guidelines. First, and principally, we endorse that oral perphenazine 8 mg (OP8) is a low-cost and efficacious tool for prevention of PONV. Second, we will demonstrate the theoretical value of the perphenazine-dexamethasone-ondansetron (P-D-O) technique (OP8, dexamethasone 4 mg intravenous ...
The goal of this clinical research study is to compare the effectiveness of receiving a combination of ondansetron and aprepitant to receiving ondansetron alone in helping to prevent nausea and/or vomiting in patients with AML or HR-MDS who are receiving cytarabine. The safety of this drug combination will also be studied.
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Dexamethasone used as an antiemetic in chemotherapy protocols inhibits natural cytotoxic (NC) cell activity. Antiemetic superiority of lorazepam over oxazepam and methylprednisolone as premedicants for patients receiving cisplatin-containing chemotherapy
AKYNZEO® is an antiemetic prescription medicine used to help prevent the nausea and vomiting caused by some chemotherapy treatments. Talk to your doctor.
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Our ability to prevent acute CINV has improved greatly as a result of drugs that inhibit 5HT-3 and substance P, but delayed CINV remains a problem.
Aprepitant (emend (SAD, EU)) je antiemetično hemijsko jedinjenje koje pripada klasi lekova koji su antagonisti supstance P (SPA).[5] On deluje putem blokiranja neurokininskog 1 (NK1) receptora. Merk proizvodi aprepitant pod imenom emend za prevenciju akutne i kasnije hemoterapijom uzrokovane mučnine i povraćanja, i za prevenciju postoperativne mučnine i povraćanja. On je dobio FDA odobrenje 2003.[6] Aprepitant isto tako možda može da bude koristan u lečenju sindroma cikličnog povraćanja, ali je do sad bilo malo istraživanje. FDA je januara 2008 odobrio fosaprepitant, koji je intravenozna forma aprepitanta. On se prodaje pod imenom emend injekcije u SAD-u i kao ivemend u nekim drugim zemljama. ...
It seems that I never have much luck with medications. Whichever I have been taking, for various illnesses, I always had to end up dealing with side effects.
Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease. In: ...
Nausea and vomiting Typically controlled using haloperidol, cyclizine; or other anti-emetics. Dyspnea (breathlessness) ...
Zotepine Antiemetics: AS-8112 • Alizapride • Bromopride • Clebopride • Domperidone • Metoclopramide • Thiethylperazine Others: ...
The two drugs are antiemetics. Serafim Guimarães: Castelo de Santa Maria da Feira. Comissão de Vigilância do Castelo de Santa ...
Antiemetic "Ipecac Syrup". Discontinued Drug Bulletin. Gardner HG (January 2007). "Office-based counseling for unintentional ...
It has antiemetic and antinociceptive effects. Pfizer was developing ezlopitant for the treatment of irritable bowel syndrome ... November 2002). "Anti-emetic activity of the novel nonpeptide tachykinin NK1 receptor antagonist ezlopitant (CJ-11,974) against ... Diemunsch P, Grélot L (September 2000). "Potential of substance P antagonists as antiemetics". Drugs. 60 (3): 533-46. doi: ...
... and using antiemetics or antihistamines before chemotherapy. Premedication before chemotherapy for cancer often consists of ...
Bermudez, J., Boyle, E. A., Miner,W. D., and Sanger, G. J. (1988). "The anti-emetic potential of the 5-hydroxytryptamine3 ... Clinical reviews indicate selective 5-HT3 receptor antagonists are an essential component of anti-emetic therapy in patients ... Multinational Association for the Support of Cancer Care (MASCC). "MASCC/ESMO Antiemetic Guidelines". Herrstedt, J., Roila, F., ... Collaborating with Gareth Sanger, who demonstrated the anti-emetic efficacy of 5-hydroxytryptamine3 (5-HT3) receptor ...
By virtue of working at the last step in triggering vomiting, it can prevent a broader range of stimuli than most antiemetics ... Maropitant is safer than other antiemetics used in veterinary medicine, in part because of its high specificity for its target ... When compared to other anti-emetics, maropitant has similar or greater effectiveness to chlorpromazine and metoclopramide for ... ISBN 978-1-4377-0282-8. Trepanier LA (February 2015). "Maropitant: Novel Antiemetic" (PDF). Clinician's Brief. Retrieved 28 ...
Medications taken to prevent and treat nausea are called antiemetics. The most commonly prescribed antiemetics in the US are ... The choice of antiemetic medication may be based on the situation during which the person experiences nausea. For people with ... Other factors to consider when choosing an antiemetic medication include the person's preference, side-effect profile, and cost ... Flake ZA, Linn BS, Hornecker JR (March 2015). "Practical selection of antiemetics in the ambulatory setting". American Family ...
... 's emetogenic effects are managed with prophylactic antiemetics. Diarrhea Oral mucositis (mouth, throat, or lip sores ...
H2 blockers and antiemetics can also be used. Bilious vomiting syndrome is a diagnosis of exclusion, meaning that the dog is ...
... is an antiemetic drug. In the United States, the combination drug netupitant/palonosetron (trade name Akynzeo) is ... Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively ...
Nausea for any reason can be treated with antiemetics. Damage to the epithelial surfaces Epithelial surfaces may sustain damage ...
Antiemetics may be administered if the patient is vomiting. Adhesive obstructions often settle without surgery. If the ...
... (INN) is a phenothiazine antiemetic. Herrstedt J (September 1998). "Chemotherapy-induced nausea and vomiting with ...
Cannabinoids: are a useful adjunct to modern anti emetic therapy in selected patients. They show a combination of weak anti ... Anti emetic drugs are chosen according to previous effectiveness and side effects. Drugs that are used in the prophylaxis and ... Their antiemetic activity when added to a 5-HT3 receptor antagonist plus dexametasone has been shown in several phase II double ... They are often used in combination with other anti emetic drugs in people with high risk of emesis or nausea and are ...
Nausea and vomiting can be treated with intravenous anti-emetics. Seizures and convulsions may be managed with benzodiazepines ...
Anti-emetics are not routinely recommended with levonorgestrel-only ECPs. If a woman vomits within 2 hours of taking a ...
Antiemetics are often administered prior to busulfan to prevent vomiting (emesis). Phenytoin may be used concurrently to ... Both IV and oral formulations require prophylactic antiemetic agents administered prior to the busulfan dose and scheduled ... antiemetics administered thereafter. Oral bioavailability of busulfan shows a large interindividual variation. Taking busulfan ...
The antiemetic medications can block the binding site on a chemoreceptor in the CTZ, so that the emetic agent cannot bind to it ... Also, some anti-emetic medications work by lowering the amount of dopamine levels in the brain, which in turn effects how much ... Another way that antiemetic medications can work is by binding to a chemoreceptor in the CTZ, but instead of initiate vomiting ... Antiemetic medications often target the CTZ to completely inhibit or greatly reduce vomiting. Most of these work by not ...
Antiemetic drugs should be given to awake persons. People with poor clinical grade on admission, acute neurologic deterioration ...
Cerium(III) oxalate is used as an antiemetic. It has been identified as part of the invisible ink that was used by Stasi ...
Dopamine receptor antagonists have sedative and antiemetic properties. Previously, they were used in parallel with opioids to ...
Antiemetics. Antiemetic medications may be helpful for treating vomiting in children. Ondansetron has some utility, with a ... "Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents". Cochrane Database of ... DeCamp LR, Byerley JS, Doshi N, Steiner MJ (September 2008). "Use of antiemetic agents in acute gastroenteritis: a systematic ... Fedorowicz, Zbys; Jagannath, Vanitha A.; Carter, Ben (2011-09-07). "Antiemetics for reducing vomiting related to acute ...
17.2 Antiemetic medicines. *17.3 Anti-inflammatory medicines. *17.4 Laxatives. *17.5 Medicines used in diarrhoea *17.5.1 Oral ...
Antiemetics - Neuroleptic Class - Phenothiazines There are many other rare causes of torticollis. A very rare cause of acquired ...
FR 2227868, "Antiemetic compositions containing piperidine derivatives" Table 1. Marketed butyrophenones with approval status ...
In conjunction with antiemetic medications, at least one study has found that application to the pericardium meridian 6 ... Glucocorticoids have direct antiemetic effects and can reduce need for postoperative opioids. Adverse effects include a ... Propofol, an anesthetic medication, confers its own antiemetic properties. The 2020 Cochrane Anaesthesia Review Group review of ... are two of the most effective anti-emetics for PONV. The review adds robust evidence of efficacy for drugs in newer classes, ...
It is also an antiemetic, antispasmodic and hypothermic agent. Additionally it is used to lower blood pressure in animals ...
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness ... Muscimol is purported to have antiemetic activity. Ajwain is purported to be antiemetic. It is a popular spice in India, ... Some antiemetics previously thought to cause birth defects appear safe for use by pregnant women in the treatment of morning ... It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT3 receptor antagonists and NK1 ...
antiemetics synonyms, antiemetics pronunciation, antiemetics translation, English dictionary definition of antiemetics. Used to ... antiemetics. Also found in: Thesaurus, Medical. antiemetics. (also called antinauseants) Used to prevent nausea and thus ... Ondansetron does not have the sedating and extrapyramidal effects associated with older antiemetics.. This antiemetic may help ... Furthermore, this dose of propofol exhibits greater antiemetic efficiency than do traditional antiemetics (metoclopramide and ...
Antiemetics. Class Summary. A review of 7 randomized, controlled trials in children found that oral ondansetron reduced ... Are antiemetics helpful in young children suffering from acute viral gastroenteritis?. Arch Dis Child. 2005 Jun. 90(6):646-8. [ ... Fedorowicz Z, Jagannath VA, Carter B. Antiemetics for reducing vomiting related to acute gastroenteritis in children and ... The mainstay of therapy includes prevention with the rotavirus vaccine and treatment with antimicrobials and antiemetics. ...
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Patient satisfaction with antiemetics correlated with QOL. PharmacoEconomics & Outcomes News volume 299, page10(2001)Cite this ... Patient satisfaction with antiemetics correlated with QOL. Pharmacoecon. Outcomes News 299, 10 (2001). https://doi.org/10.1007/ ...
The report covers forecast and analysis for the antiemetic drug market on a global and regional leve… ... Global Antiemetic Drug Market , Analysis, 2015 - 2020 * 1. Published By: Syndicate Market Research Global Antiemetic Drug ... 4. Antiemetic Drug Market [email protected]  Cannabinoids  Others Antiemetic Drug Market: Application Segment ... Chemotherapy is leading application segment of antiemetic drug market. * 3. Antiemetic Drug Market [email protected] ...
Free flashcards to help memorize facts about Antiemetics. Other activities to help include hangman, crossword, word scramble, ... Antiemetics. Question. Answer. Antihistamines: have strong anticholinergic effects. Dramamine,benadryl,vistaril,antivert ...
Used as antiemetic in low doses during chemotherapy. Usually used in multiagent antiemetic regimens with 5HT-3 receptor ... Antiemetics. Class Summary. Prevention and treatment of nausea and vomiting associated with chemotherapy. ...
Medicines called antiemetics are sometimes needed to ward off nausea and vomiting from anesthesia, chemotherapy, motion ... Medicines called antiemetics are sometimes needed to ward off nausea and vomiting from anesthesia, chemotherapy, motion ... Journal of Clinical Oncology: Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update ...
Number of antiemetic rescue medications given postoperatively.. 331. All. 18 Years to 99 Years (Adult, Older Adult). ... A Phase IV Trial of Cesamet™ Given With Standard Antiemetic Therapy for Chemotherapy-induced Nausea and Vomiting. *Nausea and ... To determine whether the addition of Cesamet to standard antiemetic regimens leads to incremental benefit in the secondary ... in control of chemotherapy induced nausea and vomiting in patients who have failed to respond adequately to standard antiemetic ...
5-HT3 Antagonists (Antiemetics) and Cardiac Safety Official Title 5-HT3 Antagonists (Antiemetics) and Cardiac Safety Using an ... 5-HT3 Antagonists (Antiemetics) and Cardiac Safety. The safety and scientific validity of this study is the responsibility of ... with the overall goal to improve the safety of these commonly used antiemetic medications. Furthermore, predictive ...
Learn about the drug Antiemetics (Phenothiazines). Includes generic and brand name examples, dosage, how the drug works, why it ... home , brain & nervous system center , brain & nervous system a-z list , antiemetics (phenothiazines) healthwise article ...
McRitchie B., McClelland C.M., Cooper S.M., Turner D.H., Sanger G.J. (1984) Dopamine Antagonists as Anti-Emetics and as ... J. Perrot, G. Nahas, C. Laville, and A. Debay, Substituted benzamides as antiemetics, in: "Treatment of cancer chemotherapy- ... Antiemetic efficacy of high-dose metoclopramide: Randomized trials with placebo and prochlorperazine in patients with ... pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic, Drugs, 24:360 ...
Antiemetics. Off-label use of ondansetron may be considered to control nausea and vomiting associated with Reye syndrome and ... Which medications in the drug class Antiemetics are used in the treatment of Reye Syndrome?. Updated: Apr 02, 2018 ...
Antiemetics. Off-label use of ondansetron may be considered to control nausea and vomiting associated with Reye syndrome and ... Which medications in the drug class Antiemetics are used in the treatment of Reye Syndrome?. Updated: Apr 02, 2018 ... encoded search term (Which medications in the drug class Antiemetics are used in the treatment of Reye Syndrome?) and Which ... medications in the drug class Antiemetics are used in the treatment of Reye Syndrome? What to Read Next on Medscape. Related ...
Find out who shouldnt take metoclopramide and who might need extra monitoring, metoclopramide pregnancy and breastfeeding info and if you can drink alcohol or drive
... antiemetics explanation free. What is antiemetics? Meaning of antiemetics medical term. What does antiemetics mean? ... Looking for online definition of antiemetics in the Medical Dictionary? ... antiemetics. Also found in: Dictionary, Thesaurus. antiemetics. Drugs used to prevent vomiting. Antiemetic drugs include ... Antiemetics , definition of antiemetics by Medical dictionary https://medical-dictionary.thefreedictionary.com/antiemetics ...
Development of a Murine Model Based on Gastric Distension to Study the Emetic and Antiemetic Potential of Drugs ...
An anti-emetic is a drug that is effective against vomiting and nausea. Anti-emetics are typically used to treat motion ... Types of Anti-emetics. Anti-emetics include: *5-HT3 receptor antagonists - these block serotonin receptors in the central ... Emetrol also claimed to be an effective anti-emetic.. *Propofol given intravenously. It has been used in an acute care setting ... Dexamethasone given in low dose at the onset of a general anaesthetic for surgery is an effective anti-emetic. The specific ...
The chart includes the formulations, strengths, and usual doses for each antiemetic drug product. ...
Antiemetic) brands plus detailed descriptions, warnings, dosage and directions. ... Rugby Travel Sickness Meclizine HCl, 25 mg Each (Antiemetic) Brands. We have 11 labels with the same name. Please choose the ... Name: Rugby Travel Sickness Meclizine HCl, 25 mg Each (Antiemetic). Form: tablet, chewable. Ingredients: MECLIZINE ... Name: Rugby Travel Sickness Meclizine HCl, 25 mg Each (ANTIEMETIC). Form: tablet, chewable. Ingredients: MECLIZINE ...
In our report you discover overall world revenue to 2024 for antiemetic medicines, with discussions.. You also find individual ... The report also explains issues, forces, and events affecting the antiemetic drugs industry and market from 2014, including ... There you hear whats happening for developers, producers, and sellers of antiemetic agents, understanding challenges, trends, ... In developed and developing countries, many opportunities for developers, producers, and sellers of antiemetic medicines will ...
Before you take granisetron, its important to tell your doctor about any medications or supplements youre taking as they may adversely interact. Thi
According to the latest market study released by Technavio, the global antiemetic drugs marketis expected to grow at a CAGR of ... Such high instances of PONV among individuals undergoing surgeries will fuel the antiemetic drugs market growth," says Sapna ... According to the latest market study released by Technavio, the global antiemetic drugs marketis expected to grow at a CAGR of ... According to Sapna Jha, a lead analyst at Technavio for cardiovascular and metabolic disorders research, "Antiemetic drugs are ...
... is an FDA-approved antiemetic formulated specifically for dogs. Cerenia is indicated for the prevention of acute vomiting and ... Antiemetic For Dogs. Cerenia Tablets (maropitant citrate) is an FDA-approved antiemetic formulated specifically for dogs. ...
3 or 4 antiemetics. 34 + 25 = 59. 51* 8. Difference in incidence (column total). 190 per 1000. 145 per 1000. 45 cases per 1000 ... We have had extensive experience with OP8 in adults as part of a multimodal antiemetic plan, with its cost at the undersigned ... Oral Perphenazine 8 mg: A Low-Cost, Efficacious Antiemetic Option. Williams, Brian A. MD, MBA; Holder-Murray, Jennifer M. MD; ... Finally, for the 60%-80% risk groups where the Consensus guideline is for 3 or 4 antiemetics, we assume half of the Consensus- ...
... for Injection received US Food and Drug Administration approval in late January for use in combination with other antiemetic ... A new formulation of Emend has entered oncologys antiemetic armamentarium. Emend (fosaprepitant dimeglumine, Merck) ... The injectable form (115 mg) can be substituted for the oral 125 mg Emend capsule on day 1 of a 3-day antiemetic regimen. FDA ... Combo Antiemetic Therapy Safe, Effective for Testicular Cancer Patients on Cisplatin Chemotherapy ...
Antiemetics and Emetics. Nausea and Vomiting. Emetic center of the brain is stimulated Goal is to empty the GI tract of ... ANTIEMETICS: NEW DEVELOPMENTS -Antiemetics of choice. cisplatin - acute emesis nk1 5-ht3 dex - delayed emesis nk1 dex or dex ... PowerPoint Slideshow about Antiemetics and Emetics - moeshe. Download Now An Image/Link below is provided (as is) to download ... Antiemetics and Emetics. Nausea and Vomiting. Emetic center of the brain is stimulated Goal is to empty the GI tract of ...
The Antiemetics market report addresses forecast and growth ... The Antiemetics market provides detailed market segment level ... The Antiemetics market provides detailed market segment level data on the international market. The Antiemetics market report ... Global Antiemetics Production, Revenue (Value) by Region (2011-2016). *Global Antiemetics Supply (Production), Consumption, ... Antiemetics Market Segmentation and Analysis by Recent Trends, Development and Growth by Regions to 2021. January 10th, 2017 ...
  • citation needed] Anticholinergics Hyoscine (also known as scopolamine) Atropine Diphenhydramine Steroids Dexamethasone (Decadron) is given in low dose at the onset of a general anesthetic as an effective antiemetic. (wikipedia.org)
  • Dexamethasone ( Decadron ) is given in low dose at the onset of a general anesthetic as an effective antiemetic. (wikipedia.org)
  • Optimization of anesthesia antiemetic measures versus combination therapy using dexamethasone or ondansetron for the prevention of postoperative nausea and vomiting. (thefreedictionary.com)
  • To the editor: The report by Cassileth and associates (1) on the use of high-dose dexamethasone an an antiemetic during induction chemotherapy for patients with acute nonlymphocytic leukemia is of concern. (annals.org)
  • 1994). Dopamine D2-receptor antagonists are effective in only about 50% of patients, whereas serotonin 5HT3-receptor antagonists, either alone or in combination with a glucocorticoid such as dexamethasone, appear to be more, but not completely, effective antiemetics against highly emetogenic regimens such as total body irradiation. (420magazine.com)
  • Some of the research also evaluated concomitant use of dexamethasone , droperidol , and other antiemetics. (empr.com)
  • Patients receive their scheduled chemotherapy regimen containing doxorubicin and their scheduled oral 5 hydroxytryptamine 3 receptor antagonist antiemetic (ondansetron, granisetron, tropisetron, or dolasetron mesylate) combined with dexamethasone on day 1. (knowcancer.com)
  • Propofol prophylaxis was compared with a multidrug regimen consisting of dexamethasone and three antiemetic drugs, ondansetron, droperidol and metoclopramide. (avhandlingar.se)
  • This update of the 2017 guideline adds guidance on the use of dexamethasone as a prophylactic antiemetic in patients receiving checkpoint inhibitors (CPIs). (guidelinecentral.com)
  • Bivariate analysis, multivariable logistic regression, and our Bayesian hierarchical model all showed a large and statistically significant association between socioeconomic markers and antiemetic prophylaxis (ondansetron and dexamethasone). (ovid.com)
  • Aprepitant (A), palonosetron (P), granisetron (G) and dexamethasone (D) are recommended as antiemetic drugs. (ovid.com)
  • We retrospectively examined the efficacy of these antiemetic drugs without dexamethasone. (ovid.com)
  • The combination with AG or AP was effective antiemetic therapy for anthracycline containing regimens in breast cancer patients who should avoid dexamethasone. (ovid.com)
  • Steroids, such as dexamethasone and methylprednisolone, are effective antiemetics that work by an undefined mechanism. (medicinalplants.us)
  • Combining propofol with another antiemetic such as serotonin antagonist, dexamethasone or droperidol, is probably the best approach. (anesthesiageneral.com)
  • However, when ondansetron was administered at the end of the operation, it significantly reduced the need for rescue antiemetics in the recovery room (36% versus 64% in the control group). (thefreedictionary.com)
  • The results of this study will enable better-informed therapeutic decision-making regarding the use of ondansetron in children and pregnant women, with the overall goal to improve the safety of these commonly used antiemetic medications. (clinicaltrials.gov)
  • 3%), and as a part of antiemetic therapy 237 patients were prescribed ondansetron, 186 granisetron and 64 palonosetron. (thefreedictionary.com)
  • Patients will be randomized to receive one of two antiemetic treatment sequences: sequence A that involves administration of ondansetron alone for 3 weeks followed by a single dose of rolapitant (day 22) plus daily ondansetron for 3 weeks or sequence B that involves a single dose of rolapitant (day 1) plus daily ondansetron for 3 weeks followed by 3 weeks of daily ondansetron alone. (clinicaltrials.gov)
  • For Medicaid versus commercially insured patients, the odds ratio of receiving the antiemetic ondansetron is 0.85 in our Bayesian hierarchical mixed regression model, with a 95% Bayesian credible interval of 0.81-0.89 with similar inferences in classical (frequentist) regression models. (ovid.com)
  • Recently antiemetics such as ondansetron have been used in secondary care setting in pediatric population. (biomedcentral.com)
  • Some commonly administered antiemetics are Promethazine (Phenergan), Ranitidine (Zantac), and Ondansetron (Zofran). (clintpharmaceuticals.com)
  • R. J. Gralla, L. M. Itri, S. E. Pisko, A. E. Squillante, D. P. Kelson, D. W. Braun, L. A. Bordin, T. J. Braun, and C. W. Young, Antiemetic efficacy of high-dose metoclopramide: Randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. (springer.com)
  • found that on average, the women used acupressure for one more day after they stopped taking antiemetics , which demonstrates acupressure's efficacy in delayed CIN. (thefreedictionary.com)
  • Although the greater antiemetic potency and efficacy of Δ8-THC relative to its isomer Δ9-THC is unusual as the latter cannabinoid possesses higher affinity and potency for cannabinoid receptors in functional assays, the current data support the results of a clinical study in children suggestive of complete protection from emesis by Δ8-THC. (420magazine.com)
  • These findings further suggest that the least shrew can be utilized as a versatile and inexpensive small animal model to rapidly screen the efficacy of investigational antiemetics for the prevention of radiation-induced emesis. (420magazine.com)
  • The D2- and 5-HT3- receptor antagonists' antiemetic efficacy have been suggested to be dependent upon selective blockade of corresponding specific dopaminergic- and serotonergic-receptor subtypes (Maranzano et al. (420magazine.com)
  • Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy-induced nausea and vomiting. (pubmedcentralcanada.ca)
  • 2 Subsequently, haloperidol has been widely used as an antiemetic for more than 40 yr, often despite a lack of evidence-based clinical data on efficacy and side effects. (asahq.org)
  • Before studying the efficacy of MCP as an antiemetic in children, we first had to establish the safe dose range. (elsevier.com)
  • Metoclopramide (2 mg/kg) had promising antiemetic efficacy in a preliminary nonrandomized trial. (elsevier.com)
  • To quantify the antiemetic efficacy and adverse effects of cannabis used for sickness induced by chemotherapy. (bmj.com)
  • 30 randomised comparisons of cannabis with placebo or antiemetics from which dichotomous data on efficacy and harm were available (1366 patients). (bmj.com)
  • Multicycle efficacy and safety of NEPA, a fixed-dose antiemetic combination of netupitant and palonosetron, in patients receiving chemotherapy of v. (esmo.org)
  • Intravenous fluids (Hartmans solution) and oral antiemetics (prochlorperazine) were administered, but vitamins were not given. (thefreedictionary.com)
  • In the early 1990s, manufacturing problems curtailed the availability of the other preferred antiemetic for these indications, parenteral prochlorperazine. (thefreedictionary.com)
  • The THC had superior antiemetic activity in comparison to placebo, but it showed no advantage over prochlorperazine. (nih.gov)
  • Compare the effectiveness of a 5 hydroxytryptamine 3 (5-HT3) receptor antagonist antiemetic vs prochlorperazine in controlling delayed nausea after chemotherapy in patients with chemotherapy-naive cancer. (knowcancer.com)
  • Compare the quality of life of patients treated with a 5-HT3 receptor antagonist antiemetic vs prochlorperazine. (knowcancer.com)
  • Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer. (wikipedia.org)
  • It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT3 receptor antagonists and NK1 receptor antagonist, but the specific mechanism of action is not fully understood. (wikipedia.org)
  • Browse detail report @ http://www.syndicatemarketresearch.com/market- analysis/antiemetic-drug-market.html Increasing incidences of various types of cancer along with the side effects of chemotherapy is major key factor of antiemetic drugs market. (slideshare.net)
  • Chemotherapy is leading application segment of antiemetic drug market. (slideshare.net)
  • Medicines called antiemetics are sometimes needed to ward off nausea and vomiting from anesthesia, chemotherapy, motion sickness or something else. (livestrong.com)
  • Its management has been refined over the past several decades, but despite the existence of effective treatments and clear antiemetic guidelines, many patients still suffer from CINV, particularly during the delayed phase after chemotherapy. (thefreedictionary.com)
  • Chemotherapy is a major segment for antiemetic drugs. (finanznachrichten.de)
  • It is well-known that the consumption of antiemetics and emesis-related care during chemotherapy is high and costly [ 10 , 11 ]. (hindawi.com)
  • EMEND for Injection is approved for use in combination with other antiemetic medicines for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic and highly emetogenic cancer chemotherapy, including high-dose cisplatin. (webwire.com)
  • EMEND for Injection (115 mg) provides a new option for patients receiving an antiemetic on Day 1 of their chemotherapy. (webwire.com)
  • EMEND for Injection and oral EMEND, when used in combination with other antiemetics, are only used to help prevent nausea and vomiting caused by chemotherapy. (webwire.com)
  • The results indicate that nabilone is an effective antiemetic for children having chemotherapy, even for young children. (nih.gov)
  • There are currently insufficient data to support the beneficial effects of dronabinol in the prevention of breakthrough chemotherapy-induced nausea and vomiting (CINV) in patients unresponsive to antiemetics, according to a review published in the journal Cancer Management and Research . (oncologynurseadvisor.com)
  • Factors impacting the incidence of delayed CINV include dose and emetogenicity of chemotherapy agent(s), incidence of acute CINV, patient age, sex, and prophylactic antiemetics used. (oncologynurseadvisor.com)
  • Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. (nih.gov)
  • It contains graded recommendations for antiemetics in adults and children including tables of risk categories for chemotherapy and radiotherapy and cost of products. (guidelinecentral.com)
  • The development of increasingly effective antiemetic regimens over the last quarter century has greatly reduced the incidence of nausea and vomiting due to chemotherapy. (guidelinecentral.com)
  • Note: For adult patients, the addition of a checkpoint inhibitor to chemotherapy does not change the guideline recommendation for an antiemetic regimen based on the emetogenicity of the agents administered. (guidelinecentral.com)
  • Prolongation of the antiemetic action of P6 acupuncture by acupressure in patients having cancer chemotherapy. (pubmedcentralcanada.ca)
  • Nausea and vomiting remain problems with cancer chemotherapy despite the use of antiemetics. (pubmedcentralcanada.ca)
  • Following encouraging results with P6 acupuncture (ACP) in postoperative sickness this has been shown to be effective in cancer chemotherapy in 105 patients who, despite the use of conventional antiemetics had been sick following the previous treatment. (pubmedcentralcanada.ca)
  • Clinical trials with antiemetic agents in cancer patients receiving chemotherapy. (pubmedcentralcanada.ca)
  • Williams CJ, Davies C, Raval M, Middleton J, Luken J, Stone B. Comparison of starting antiemetic treatment 24 hours before or concurrently with cytotoxic chemotherapy. (pubmedcentralcanada.ca)
  • Midazolam can be given safely to patients receiving chemotherapy with and without concomitant antiemetics. (elsevier.com)
  • Gralla, Richard J. / Midazolam in patients receiving anticancer chemotherapy and antiemetics . (elsevier.com)
  • Specific Medicinal Uses of Cannabis: Use as an Antiemetic Many agents used in cancer chemotherapy produce severe nausea and vomiting in most patients. (medicinalplants.us)
  • Prior studies in adults have shown that metoclopramide (MCP), when given in high intravenous (IV) doses (2 mg/kg), is a highly effective antiemetic for chemotherapy-induced vomiting. (elsevier.com)
  • Chemotherapy-induced emesis has the same negative implications in children as it does in adults and optimum antiemetic regimens can only be discovered by conducting randomized clinical trials in children. (elsevier.com)
  • An up-to-date overview of the selection of antiemetic drugs, of their dosage and route of administration is given for clinical conditions such as emetogenic anti-cancer chemotherapy, radiation therapy, surgery, and hyperemesis gravidarum. (blogspot.com)
  • Furthermore, this dose of propofol exhibits greater antiemetic efficiency than do traditional antiemetics (metoclopramide and droperidol) (27). (thefreedictionary.com)
  • Antiemetic drugs include metoclopramide (Maxolon) and domperidone (Motilium). (thefreedictionary.com)
  • Despite current guidelines recommending dronabinol for the management of breakthrough CINV, there are limited data to support its routine use as an antiemetic in all chemotherapeutic regimens. (oncologynurseadvisor.com)
  • Three antiemetic regimens were used. (ovid.com)
  • Additionally, increasing prevalence of lifestyle induced diseases expected to boost demand for antiemetic drugs during the forecast period. (slideshare.net)
  • Patients were given Sea-Band acupressure wristbands instead of antiemetic drugs during a migraine attack and 83 percent of patients noticed reduction of nausea. (thefreedictionary.com)
  • According to the latest market study released by Technavio , the global antiemetic drugs market is expected to grow at a CAGR of more than 6% during the forecast period. (finanznachrichten.de)
  • This research report titled ' Global Antiemetic Drugs Market 2017-2021 ' provides an in-depth analysis of the market in terms of revenue and emerging market trends. (finanznachrichten.de)
  • Antiemetic drugs are widely used for the management of various disease conditions and to treat the side effects associated with various drugs. (finanznachrichten.de)
  • Various formulatory advancements such as formulation in the form of patches, intranasal sprays, and other newer formulatory are expected to fuel antiemetic drugs market. (finanznachrichten.de)
  • The market research analysis categorizes the global antiemetic drugs market into three major application segments. (finanznachrichten.de)
  • Its incidence can reach 80% in high-risk patients, and remains high despite the emergence of new antiemetic drugs. (clinicaltrials.gov)
  • Previous work from our department has shown that P6 acupuncture is an effective adjuvant to conventional antiemetic therapy for patients having cytotoxic drugs. (pubmedcentralcanada.ca)
  • To prevent this, use antiemetic drugs. (womeninahomeoffice.com)
  • 32. Antiemetic drugs. (brainscape.com)
  • Which are the groups of antiemetic drugs? (brainscape.com)
  • Which are the 5-HT 3 receptor antagonists, antiemetic drugs? (brainscape.com)
  • Which are the D 2 receptor antagonists, antiemetic drugs? (brainscape.com)
  • Which are the H 1 antagonists, antiemetic drugs (vestibular emesis)? (brainscape.com)
  • In this article, we will cover in detail the various antiemetics, their mechanism of action, adverse effects/toxicity, contraindications, drug interactions and drugs of choice. (lecturio.com)
  • The lecture Nausea Medication: Antiemetics - Gastrointestinal Drugs by Pravin Shukle, MD is from the course Gastrointestinal Pharmacology. (lecturio.com)
  • This book combines an overview of the preclinical research on antiemetic drugs and state-of-the art reviews on the prevention and treatment of nausea and emesis. (blogspot.com)
  • Care related to emesis thus includes, for example, intravenous nutrition in patients with reduced eating capacity, rescue antiemetic medications, need for sick transportations or hospitalising [ 7 ]. (hindawi.com)
  • Breakthrough emesis is considered vomiting that occurs even with prophylactic treatment and/or requires the addition of "rescue" antiemetics. (oncologynurseadvisor.com)
  • Refractory emesis is classified as vomiting that occurs with subsequent treatment when prophylactic antiemetics and/or rescue medications have been ineffective in previous cycles. (oncologynurseadvisor.com)
  • Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew. (semanticscholar.org)
  • The panel found evidence from a phase III randomized controlled trial that showed that adding olanzapine to antiemetic prophylaxis reduces the risk of nausea among adult patients treated with high emetic-risk antineoplastic agents. (clinicaladvisor.com)
  • Patients treated with multi-day antineoplastic agents should be offered antiemetics before treatment and administered on each day of the antineoplastic treatment and for 2 days after the regimen is completed. (clinicaladvisor.com)
  • Cannabinoids present an interesting therapeutic potential as antiemetics, appetite stimulants in debilitating diseases (cancer, AIDS and multiple sclerosis), analgesics, and in the treatment of multiple sclerosis and cancer, among other conditions. (thctotalhealthcare.com)
  • Number of antiemetic rescue medications given postoperatively. (clinicaltrials.gov)
  • Which medications in the drug class Antiemetics are used in the treatment of Reye Syndrome? (medscape.com)
  • Use of antiemetic and rescue medications was adjusted for optimal effect. (thefreedictionary.com)
  • CINV is one of the most common symptoms feared by patients with cancer, but it may be prevented or lessened with antiemetic medications. (oncologynurseadvisor.com)
  • Coke syrup, ginger, and motion sickness medications are examples of antiemetics. (thefreedictionary.com)
  • Emend (fosaprepitant dimeglumine, Merck) for Injection received US Food and Drug Administration approval in late January for use in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting associated with initial and repeated courses of moderate- or high-emetogenic chemotherapies, including high-dose cisplatin. (cancernetwork.com)
  • Numerous antiemetic agents exist to manage CINV, including corticosteroids, 5HT 3 receptor antagonists, and neurokinin receptor antagonists. (oncologynurseadvisor.com)
  • Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists. (sigmaaldrich.com)
  • In addition, these data support the validation of the least shrew as a specific and rapid behavioral animal model to screen concomitantly both the CNS penetration and the antiemetic potential of tachykinin NK1 receptor antagonists. (sigmaaldrich.com)
  • Consideration should be made to repeating this study excluding nitrous oxide and using double agent antiemetics to determine if the incidence of vomiting associated with the additional subhypnotic propofol technique might be further reduced. (thefreedictionary.com)
  • It was also proposed that propofol possesses antiemetic effects. (avhandlingar.se)
  • Zabetian H, Kalani N, Khalili A, Sahraei R, Radmehr M (2016) Antiemetic Effects of Midazolam and Propofol during Spinal Anesthesia on Women Undergoing Elective Cesarean Sections. (omicsonline.org)
  • Comparison of the antiemetic effects of propofol and midazolam in pregnant women after elective caesarean section showed that in all minutes, except in the thirtieth minute, nausea and vomiting were higher in the midazolam group and a significant difference was observed between two groups in this regard (p=0.96). (omicsonline.org)
  • Propofol is known to possess direct antiemetic effects. (anesthesiageneral.com)
  • Propofol antiemetic use for induction and maintenance of anesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anesthetic drug or technique. (anesthesiageneral.com)
  • A subhypnotic dose (1.0 mg/kg/h) of propofol antiemetic in continuous infusion can be effective for preventing nausea and vomiting. (anesthesiageneral.com)
  • In the postoperative period, the advantage of propofol antiemetic is its rapid onset of action and the absence of serious side effects. (anesthesiageneral.com)
  • Propofol antiemetic is generally efficacious in treating postoperative nausea and vomiting at plasma concentrations that do not produce increased sedation. (anesthesiageneral.com)
  • The properties of propofol antiemetic at subhypnotic doses are not mediated via interactions with the dopaminergic system. (anesthesiageneral.com)
  • It is possible that propofol antiemetic modulates subcortical pathways to inhibit nausea and vomiting or produces direct depressant effect on the vomiting center. (anesthesiageneral.com)
  • Technavio has published a new report on the global antiemetic drug market from 2017-2021. (finanznachrichten.de)
  • The injectable form (115 mg) can be substituted for the oral 125 mg Emend capsule on day 1 of a 3-day antiemetic regimen. (cancernetwork.com)
  • An antiemetic is a drug that is effective against vomiting and nausea. (wikipedia.org)
  • To determine whether antiemetics reduce vomiting and decrease need for further intervention without significant adverse effects, University of North Carolina researchers performed a systematic review and meta-analysis of prospective controlled trials evaluating medication use in children with vomiting from gastroenteritis. (thefreedictionary.com)
  • To determine the value of antiemetics in relieving vomiting, the investigators reviewed findings from 11 studies on this topic. (thefreedictionary.com)
  • Since its release in 1970, droperidol had been one of the preferred antiemetics for the prevention and treatment of postoperative nausea and vomiting (PONV) and the treatment of hyperemesis gravidarum (HG). (thefreedictionary.com)
  • The advent of effective antiemetics and short-acting anesthetic agents has significantly reduced the incidence of postoperative nausea and vomiting. (thefreedictionary.com)
  • 2. Antiemetic Drug Market [email protected] Nausea and vomiting that can be caused by many conditions. (slideshare.net)
  • they found that the incidence of nausea and vomiting, severe pain, periorbital oedema, double vision and the use of rescue antiemetics was significantly reduced in patients receiving colloids. (thefreedictionary.com)
  • Eliminating Postoperative Nausea and Vomiting in Outpatient Surgery with Multimodal Strategies including Low Doses of Nonsedating, Off-Patent Antiemetics: Is "Zero Tolerance" Achievable? (hindawi.com)
  • A cross-sectional selection of 368 cancer patients treated with radiotherapy answered a questionnaire (=93% answering rate) regarding nausea, vomiting, actual use of and interest in antiemetic treatment, quality of life and psychological and functional status during the preceding week of radiotherapy. (diva-portal.org)
  • Xenobiotic cannabinoid CB1/CB2-receptor agonists appear to possess broad-spectrum antiemetic activity since they prevent vomiting produced by a variety of emetic stimuli including the chemotherapeutic agent cisplatin, serotonin 5-HT3-receptor agonists, dopamine D2/D3-receptor agonists and morphine, via the stimulation of CB1-receptors. (420magazine.com)
  • While an antiemetic drug plus a glucocorticoid is commonly used to prevent nausea and vomiting after surgical procedures, a new review published in BMC Medicine indicates that this combination may increase a patient's risk of arrhythmia . (empr.com)
  • Providing effective implementation of antiemetic strategies: the postoperative nausea and vomiting-free hospital is a laudable and realistic goal. (sigmaaldrich.com)
  • No study expressly answered the question as to whether antiemetics lessen the vomiting associated specifically with rotavirus gastroenteritis infection in children and increase the likelihood that oral rehydration therapy will be successful. (bmj.com)
  • Adherence to antiemetic guidelines has been linked with improved control of nausea and vomiting. (guidelinecentral.com)
  • This group of patients has a high incidence of postoperative nausea and vomiting, and antiemetic treatment is important and valuable. (semanticscholar.org)
  • For example, antiemetic neuroleptics vomiting, perhaps, will stop, but they will inject the patient into a depressive state. (womeninahomeoffice.com)
  • Relevant randomized trials compared haloperidol as an antiemetic (experimental intervention) with another antiemetic, placebo, or no treatment (control intervention) and reported on dichotomous data regarding the presence or absence of nausea or vomiting or haloperidol-related adverse reactions. (asahq.org)
  • Thus despite being a subject of controversy, a number of antiemetic agents are now commonly administered worldwide in an attempt to reduce vomiting in children with AGE. (biomedcentral.com)
  • Family Practice, Internal Medicine Physicians, and Anesthesiologists among the many Medical Practitioners who administer antiemetics for the treatment of nausea, vomiting, and vertigo in both acute and chronic presentations. (clintpharmaceuticals.com)
  • Although conventional therapies such as antiemetics and prokinetics are commonly used to manage acute nausea and vomiting, they are historically not as effective in treating chronic nausea. (thctotalhealthcare.com)
  • If you have severe nausea and vomiting and natural remedies such as gingersnaps or ginger tea don't relieve the problem, your doctor may recommend an antiemetic medication that is safe to use during pregnancy. (familyeducation.com)
  • ANTIEMETICS are used to prevent vomiting . (medicinalplants.us)
  • We now propose a "zero-tolerance" antiemetic algorithm for outpatients that involves routine prophylaxis by first avoiding volatile agents and opioids to the extent possible, using locoregional anesthesia, multimodal analgesia, and low doses of three nonsedating off-patent antiemetics. (hindawi.com)
  • Antiemetic prophylaxis with promethazine or ondans. (who.int)
  • We investigated antiemetic prophylaxis as a surrogate marker for anesthesia quality by individual providers because antiemetics are universally available, indicated contingent on patient characteristics (gender, age, etc), but independent of comorbidities and not yet impacted by regulatory or financial constraints. (ovid.com)
  • We hypothesized that socioeconomic indicators (measured as insurance status or median income in the patients' home zip code area) are associated with the utilization of antiemetic prophylaxis (as a marker of anesthesia quality). (ovid.com)
  • Six institutions reported on antiemetic prophylaxis for 441,645 anesthesia cases. (ovid.com)
  • Our analyses of NACOR anesthesia records raise concerns that patients with lower socioeconomic status may receive inferior anesthesia care provided by individual anesthesiologists, as indicated by less antiemetics administered. (ovid.com)
  • Drug therapy can include antiemetics , prokinetic agents, and proton pump inhibitors to limit acid, which slows gastric emptying. (thefreedictionary.com)
  • ChlorproMAZINE and other phenothiazines are sometimes effective antiemetic agents. (thefreedictionary.com)
  • The Antiemetics GUIDELINES Pocket Guide is based on the latest guidelines of the American Society of Clinical Oncology and was developed with their collaboration. (guidelinecentral.com)
  • The mainstay of therapy includes prevention with the rotavirus vaccine and treatment with antimicrobials and antiemetics. (medscape.com)
  • CPIs administered alone or in combination with another checkpoint inhibitor are minimally emetogenic and do not require the routine use of a prophylactic antiemetic. (guidelinecentral.com)
  • In our patient, the absence of vomited or significant gastric blood and the presence of melaena stools may partly be attributed to prophylactic antiemetic treatment with tropisetron. (semanticscholar.org)
  • It can be recommended as an alternative to conventional antiemetic treatment throughout childhood. (nih.gov)
  • However, lack of suitable animal model to imitate the human responses to antiemetic therapy hampers the market growth. (slideshare.net)
  • Patient response to antiemetic therapy may change over time, requiring reassessments and modifications to antiemetic strategies as warranted. (clinicaladvisor.com)
  • The antiemetic activity and side-effects of delta-9-tetrahydrocannabinol (THC) were evaluated in 116 patients (median age 61 years) receiving combined 5-fluorouracil and semustine (methyl CCNU) therapy for gastrointestinal carcinoma. (nih.gov)
  • Antiemetic therapy remains less than optimal in this setting. (nih.gov)
  • You wonder whether administration of an antiemetic may lessen her symptoms and increase the likelihood that oral rehydration therapy will be successful. (bmj.com)
  • Music therapy has been utilized to deepen the sedation level and decrease patient anxiety, antiemetic and analgesic requirements, hospital length of stay, and fatigue. (frontiersin.org)
  • With increasing population and incidences of gastroenteritis diseases in the Asia Pacific region has boost up the demand for antiemetic drug and expected to fuel market growth in this region. (slideshare.net)
  • Use of antiemetic agents in acute gastroenteritis: a systematic review and meta-analysis. (thefreedictionary.com)
  • Are antiemetics helpful in young children suffering from acute viral gastroenteritis? (bmj.com)
  • In this review we estimate the effect of antiemetics in gastroenteritis in children. (biomedcentral.com)
  • Antiemetics are effective for the management of gastroenteritis in children and have the potential to decrease morbidity and mortality burden due to diarrhea, when introduced and scaled up. (biomedcentral.com)
  • However, before haloperidol can be recommended for this indication, its antiemetic dose range, minimal effective dose, and adverse effects must be defined. (asahq.org)
  • Cerenia Tablets (maropitant citrate) is an FDA-approved antiemetic formulated specifically for dogs. (medi-vet.com)
  • Emetrol is also claimed to be an effective antiemetic. (wikipedia.org)
  • The global antiemetic surgery treatment market is growing at a high rate compared with other segments, owing to greater acceptance of surgical procedures in recent years due to higher technical advancement making the procedures safe and effective. (finanznachrichten.de)
  • What antiemetic for children will be the most effective? (womeninahomeoffice.com)
  • 3 Haloperidol, which is an old and inexpensive drug, may prove to be an interesting and cost-effective alternative to newer and more costly antiemetics. (asahq.org)
  • While conventional therapies such as antiemetics (antiserotoninergic, antihistaminic, antidopaminergic) and prokinetics are commonly used to manage acute nausea, they are not as effective in improving chronic nausea. (thctotalhealthcare.com)
  • Cerenia 24mg Tablets are a unique antiemetic that provides effective relief from sickness and nausea in dogs. (365vet.co.uk)
  • Some antiemetics previously thought to cause birth defects appear safe for use by pregnant women in the treatment of morning sickness and the more serious hyperemesis gravidarum. (wikipedia.org)
  • Antiemetics were used by 17% and 78% were interested in or wanted more information about acupuncture treatment against nausea. (diva-portal.org)
  • Cinnarizine (UK only) Cyclizine Diphenhydramine (Benadryl) Dimenhydrinate (Gravol, Dramamine) Doxylamine Mirtazapine (Remeron) is an antidepressant that also has antiemetic effects it is also a potent histamine H1 receptor antagonist, Ki=1.6 nM. (wikipedia.org)
  • Mirtazapine ( Remeron ) is an antidepressant that also has antiemetic effects [4] [5] it is also a potent histamine H1 receptor antagonist, K i =1.6 nM. (wikipedia.org)
  • Benzquinamide is an antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. (pharmacycode.com)
  • The SNBL subsidiaries specialize in nasal drug delivery: Translational Research has expertise in drug delivery technologies designed for insulin, morphine and antiemetics , while Bioactis has developed Fit-lizer, a proprietary medical device for delivering agents to the nose. (thefreedictionary.com)
  • These belong to a class of agents called antiemetics. (news-medical.net)
  • Antiemetics also significantly reduced the intravenous fluid requirements by 60%, while it had a non-significant effect on the ORT tolerance and revisit rates. (biomedcentral.com)