DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
AntiemeticsVomitingOndansetronNauseaPostoperative Nausea and VomitingProchlorperazineMetoclopramideDroperidolGranisetronPhenothiazinesVomiting, AnticipatoryAcupressureSerotonin 5-HT3 Receptor AntagonistsSerotonin AntagonistsNeurokinin-1 Receptor AntagonistsAcupuncture PointsDexamethasoneAntineoplastic AgentsDouble-Blind MethodNeoplasmsPain, PostoperativeCisplatinDrug Administration ScheduleTreatment OutcomeAntineoplastic Combined Chemotherapy ProtocolsDose-Response Relationship, DrugProspective Studies
Antiemetics
Drugs used to prevent NAUSEA or VOMITING.
Vomiting
The forcible expulsion of the contents of the STOMACH through the MOUTH.
Ondansetron
A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.
Nausea
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Postoperative Nausea and Vomiting
Emesis and queasiness occurring after anesthesia.
Prochlorperazine
A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)
Metoclopramide
A dopamine D2 antagonist that is used as an antiemetic.
Droperidol
A butyrophenone with general properties similar to those of HALOPERIDOL. It is used in conjunction with an opioid analgesic such as FENTANYL to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as an antiemetic, and for the control of agitation in acute psychoses. (From Martindale, The Extra Pharmacopoeia, 29th ed, p593)
Granisetron
A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
Phenothiazines
Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.
Vomiting, Anticipatory
Vomiting caused by expectation of discomfort or unpleasantness.
Acupressure
A type of massage in which finger pressure on specific body sites is used to promote healing, relieve fatigue, etc. Although the anatomical locations are the same as the ACUPUNCTURE POINTS used in ACUPUNCTURE THERAPY (hence acu-), no needle or other acupuncture technique is employed in acupressure. (From Random House Unabridged Dictionary, 2d ed). Shiatsu is a modern outgrowth that focuses more on prevention than healing.
Serotonin 5-HT3 Receptor Antagonists
Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.
Serotonin Antagonists
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.
Neurokinin-1 Receptor Antagonists
Compounds that inhibit or block the activity of NEUROKININ-1 RECEPTORS.
Acupuncture Points
Designated locations along nerves or organ meridians for inserting acupuncture needles.
Dexamethasone
An anti-inflammatory 9-fluoro-glucocorticoid.
Antineoplastic Agents
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Double-Blind Method
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Pain, Postoperative
Pain during the period after surgery.
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Drug Administration Schedule
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Treatment Outcome
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Antineoplastic Combined Chemotherapy Protocols
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.
Prospective Studies
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Role of dexamethasone dosage in combination with 5-HT3 antagonists for prophylaxis of acute chemotherapy-induced nausea and vomiting. (1/720)

Dexamethasone (20 mg) or its equivalent in combination with 5-HT3 antagonists appears to be the gold-standard dose for antiemetic prophylaxis. Additional to concerns about the use of corticosteroids with respect to enhanced tumour growth or impaired killing of the tumour cells, there is evidence that high-dosage dexamethasone impairs the control of delayed nausea and emesis, whereas lower doses appear more beneficial. To come closer to the most adequate dose, we started a prospective, single-blind, randomized trial investigating additional dosage of 8 or 20 mg dexamethasone to tropisetron (Navoban), a 5-HT3 receptor antagonist, in cis-platinum-containing chemotherapy. After an interim analysis of 121 courses of chemotherapy in 69 patients, we have been unable to detect major differences between both treatment alternatives. High-dose dexamethasone (20 mg) had no advantage over medium-dose dexamethasone with respect to objective and subjective parameters of acute and delayed nausea and vomiting. In relation to concerns about the use of corticosteroids in non-haematological cancer chemotherapy, we suggest that 8 mg or its equivalent should be used in combination with 5-HT3 antagonists until further research proves otherwise.  (+info)

Antiemetic efficacy of granisetron plus dexamethasone in bone marrow transplant patients receiving chemotherapy and total body irradiation. (2/720)

Few trials exist regarding the antiemetic efficacy of granisetron in bone marrow transplant (BMT) recipients conditioned with high-dose chemotherapy and total body irradiation (TBI). In this single-center, open-label, prospective, trial, the antiemetic efficacy and safety of granisetron plus dexamethasone were evaluated in 26 patients conditioned with cyclophosphamide-containing regimens (the majority receiving 60 mg/kg per day on 2 consecutive days), and TBI (12 Gy divided over 4 days). Daily intravenous doses of granisetron 1 mg plus dexamethasone 10 mg were given 30 min prior to chemotherapy or radiation, and continued for 24 h after the last conditioning treatment for a median of 6 days (range 3-9). Emetic control was defined by the number of emetic episodes occurring within a 24 h period, or the requirement for rescue medication for nausea or vomiting. A total of 25 patients completed 186 evaluable treatment days. Response (emetic control by treatment days) was complete in 50% of patients, major in 48%, minor in 2%, and there were no failures. Adverse effects were minor, with diarrhea (15%), headache (14%), and constipation (11%) reported most often. Based on these results, the antiemetic regimen of granisetron plus dexamethasone appears effective and well tolerated during BMT conditioning with high-dose cyclophosphamide and TBI.  (+info)

Antiemetic efficacy of granisetron: a randomized crossover study in patients receiving cisplatin-containing intraarterial chemotherapy. (3/720)

BACKGROUND: Cisplatin (CDDP) is one of the most active chemotherapeutic agents but is among the most emetogenic drugs. The emetic side-effects of CDDP-containing intraarterial chemotherapy have not been evaluated in a prospective randomized trial and the efficacy of serotonin antagonists in preventing the emesis associated with this method of CDDP administration has not been assessed. METHODS: CDDP 50 mg/m2 and methotrexate 30 mg/m2 were administered every 3 weeks through intraarterial catheters placed in the bilateral internal iliac arteries. Patients were classified into two groups: granisetron treatment group (group G) and no treatment group (group NG) with the first course of chemotherapy, crossing over with the second course. The patients in group G received granisetron 40 micrograms/kg by intravenous infusion. RESULTS: Although intraarterial CDDP administration produced less emesis than intravenous CDDP administration, at the same concentration, gastrointestinal toxicity is still the most unpleasant side-effect for patients. Granisetron administration significantly reduced nausea and vomiting during the acute emetic phase (an evaluation of treatment as very effective and effective was made in 89% in group G and 33% in group NG (P < 0.001). Complete control of emesis was achieved in 68 and 18% of patients in groups G and NG, respectively (P < 0.0001). CONCLUSION: A single prophylactic infusion of granisetron was effective in preventing the nausea and vomiting associated with intraarterial CDDP-containing therapy.  (+info)

Tropisetron (Navoban) in the control of nausea and vomiting induced by combined cancer chemotherapy in children. (4/720)

BACKGROUND: We aimed to assess the potency and efficacy of tropisetron, a 5-HT3 receptor antagonist, in the prevention of nausea and emesis observed in the pediatric patient population taking various chemotherapy protocols. METHODS: Tropisetron (Navoban) was given to 100 children (62 boys and 38 girls aged 6 months to 15 years) with various malignancies. Patients received tropisetron during one or more courses of emetogenic chemotherapy for a total of 350 courses administered intravenously or intravenously and intrathecally. Tropisetron (0.2 mg/kg/day, maximum: 5 mg/day) was administered as a single intravenous dose slowly, before the start of chemotherapy on day 1 and intravenously or by mouth on subsequent days (median treatment duration: 5 days). RESULTS: The patients receiving cytotoxic chemotherapy had a 70% complete response rate and a 24% partial response rate during the first 24 h period of the first course. We observed headache (five courses), diarrhea (three courses) and loss of appetite (one course) as side-effects (2.5%). CONCLUSION: Tropisetron is safe, effective, easy to use, has no serious side-effects and can be recommended for pediatric patients. The efficacy of tropisetron may be enhanced by the addition of corticosteroids in patients receiving highly emetogenic cancer chemotherapy.  (+info)

Postoperative analgesia and vomiting, with special reference to day-case surgery: a systematic review. (5/720)

BACKGROUND: Day-case surgery is of great value to patients and the health service. It enables many more patients to be treated properly, and faster than before. Newer, less invasive, operative techniques will allow many more procedures to be carried out. There are many elements to successful day-case surgery. Two key components are the effectiveness of the control of pain after the operation, and the effectiveness of measures to minimise postoperative nausea and vomiting. OBJECTIVES: To enable those caring for patients undergoing day-case surgery to make the best choices for their patients and the health service, this review sought the highest quality evidence on: (1) the effectiveness of the control of pain after an operation; (2) the effectiveness of measures to minimise postoperative nausea and vomiting. METHODS: Full details of the search strategy are presented in the report. RESULTS - ANALGESIA: The systematic reviews of the literature explored whether different interventions work and, if they do work, how well they work. A number of conclusions can be drawn. RESULTS-ANALGESIA, INEFFECTIVE INTERVENTIONS: There is good evidence that some interventions are ineffective. They include: (1) transcutaneous electrical nerve stimulation in acute postoperative pain; (2) the use of local injections of opioids at sites other than the knee joint; (3) the use of dihydrocodeine, 30 mg, in acute postoperative pain (it is no better than placebo). RESULTS-ANALGESIA, INTERVENTIONS OF DOUBTFUL VALUE: Some interventions may be effective but the size of the effect or the complication of undertaking them confers no measurable benefit over conventional methods. Such interventions include: (1) injecting morphine into the knee joint after surgery: there is a small analgesic benefit which may last for up to 24 hours but there is no clear evidence that the size of the benefit is of any clinical value; (2) manoeuvres to try and anticipate pain by using pre-emptive analgesia; these are no more effective than standard methods; (3) administering non-steroidal anti-inflammatory drugs (NSAIDs) by injection or per rectum in patients who can swallow; this appears to be no more effective than giving NSAIDs by mouth and, indeed, may do more harm than good; (4) administering codeine in single doses; this has poor analgesic efficacy. RESULTS-ANALGESIA, INTERVENTIONS OF PROVEN VALUE: These include a number of oral analgesics including (at standard doses): (1) dextropropoxyphene; (2) tramadol; (3) paracetamol; (4) ibuprofen; (5) diclofenac. Diclofenac and ibuprofen at standard doses give analgesia equivalent to that obtained with 10 mg of intramuscular morphine. Each will provide at least 50% pain relief from a single oral dose in patients with moderate or severe postoperative pain. Paracetamol and codeine combinations also appear to be highly effective, although there is little information on the standard doses used in the UK. The relative effectiveness of these analgesics is compared in an effectiveness 'ladder' which can inform prescribers making choices for individual patients, or planning day-case surgery. Dose-response relationships show that higher doses of ibuprofen may be particularly effective. Topical NSAIDs (applied to the skin) are effective in minor injuries and chronic pain but there is no obvious role for them in day-case surgery. RESULTS-POSTOPERATIVE NAUSEA AND VOMITING: The proportion of patients who may feel nauseated or vomit after surgery is very variable, despite similar operations and anaesthetic techniques. Systematic review can still lead to clear estimations of effectiveness of interventions. Whichever anti-emetic is used, the choice is often between prophylactic use (trying to prevent anyone vomiting) and treating those people who do feel nauseated or who may vomit. Systematic reviews of a number of different anti-emetics show clearly that none of the anti-emetics is sufficiently effective to be used for prophylaxis. (ABSTRACT TRUNCATE  (+info)

Prophylactic antiemetic therapy with a combination of granisetron and dexamethasone in patients undergoing middle ear surgery. (6/720)

We have compared the efficacy of granisetron in combination with dexamethasone with each drug alone in the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. In a randomized, double-blind study, 120 patients (85 females) received granisetron 3 mg, dexamethasone 8 mg or granisetron 3 mg with dexamethasone 8 mg i.v. (n = 40 in each group), immediately before induction of anaesthesia. A standardized general anaesthetic technique was used. A complete response, defined as no PONV and no need for another rescue antiemetic during the first 3 h after anaesthesia, was recorded in 83%, 50% and 98% of patients who had received granisetron, dexamethasone and granisetron-dexamethasone, respectively. The corresponding incidences during the next 21 h after anaesthesia were 80%, 55% and 98% (P < 0.05; overall Fisher's exact probability test). In summary, prophylactic use of combined granisetron and dexamethasone was more effective than each antiemetic alone for the prevention of PONV after middle ear surgery.  (+info)

Nausea during pregnancy and congenital heart defects: a population-based case-control study. (7/720)

The authors investigated the possible association between a mother's nausea during pregnancy and her child's risk for a congenital heart defect using data from the population-based Atlanta Birth Defects Case-Control Study conducted in 1982-1983. Case infants (n = 998) had nonsyndromic congenital heart defects and control infants (n = 3,029) had no congenital defects. Nausea during pregnancy (NP) was graded in eight levels of "severity" based on its onset, frequency, and duration. Level 1, the most severe NP, was associated with a lower risk for a congenital heart defect in the child (odds ratio (OR) = 0.81, 95% confidence interval (CI) 0.67-0.99) compared with no nausea. The lower risk tended to disappear with less severe levels of nausea, and the trend was statistically significant. Overall, early NP (levels 1 to 4 combined) with use of antinausea medication, particularly Bendectin (doxylamine, dicyclomine (dropped from the formulation in 1976), pyridoxine (vitamin B6)), was associated with a lower risk for congenital heart defects compared with: 1) absence of nausea (OR = 0.67, 95% CI 0.50-0.92), and 2) nausea without medication use (OR = 0.70, 95% CI 0.50-0.94). The results suggest that pregnancy hormones and factors or, alternatively, a component of Bendectin (most probably pyridoxine) may be important for normal heart development. These findings outline potential areas for future research on and prevention of congenital heart defects.  (+info)

Granisetron (Kytril) suppresses methotrexate-induced nausea and vomiting among patients with inflammatory arthritis and is superior to prochlorperazine (Stemetil). (8/720)

OBJECTIVE: Methotrexate (MTX) is an increasingly popular anti-rheumatic drug with its usefulness limited by toxicity, most commonly gastrointestinal (GI). The aim of the study was to study the effectiveness of the 5-HT3 receptor antagonist granisetron (GR) in the therapy of MTX-induced nausea. METHODS: A single-blind 8 week pilot study with random allocation to either GR 1 mg or prochlorperazine (Stemetil; PCh) 10 mg was undertaken in 13 patients who were taking or had taken MTX for either rheumatoid arthritis (10) or psoriatic arthritis (3). RESULTS: One in six patients treated with PCh completed the 8 week study compared to 7/7 treated with GR. After switching of symptomatic patients, 11 completed the study on GR and median improvement was by two grades (P < 0.001) with a significantly better visual analogue scale score for patient satisfaction compared to PCh. CONCLUSION: Treatment with GR may be useful in establishing and maintaining some patients on MTX where GI toxicity would have precluded such therapy.  (+info)

The cost of antiemetic therapy for chemotherapy-induced nausea and vomiting in patients receiving platinum-containing regimens...
TY - JOUR. T1 - The cost of antiemetic therapy for chemotherapy-induced nausea and vomiting in patients receiving platinum-containing regimens in daily practice in Japan. T2 - A retrospective study. AU - Hamada, Shota. AU - Hinotsu, Shiro. AU - Hori, Katsuhito. AU - Furuse, Hiroshi. AU - Oikawa, Takehiro. AU - Kawakami, Junichi. AU - Ozono, Seiichiro. AU - Akaza, Hideyuki. AU - Kawakami, Koji. PY - 2012/4. Y1 - 2012/4. N2 - Purpose The objective of this study was to estimate the cost of antiemetic therapy for chemotherapy-induced nausea and vomiting (CINV) in daily practice in Japan. Methods This was a retrospective observational study using medical records. Eligible patients were those with bladder or testicular cancer receiving platinum-containing highly emetogenic chemotherapy. The incidence of CINV on days 1-5 in single-day chemotherapy and on days 1-9 in multiple-day chemotherapy, and the costs of antiemetic therapy directly associated with the administration of antiemetics were estimated. ...
https://okayama.pure.elsevier.com/en/publications/the-cost-of-antiemetic-therapy-for-chemotherapy-induced-nausea-an
Treatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and VomitingTreatment of Breakthrough and Refractory Chemotherapy-Induced Nausea and Vomiting
Despite significant progress in the prevention of chemotherapy-induced nausea and vomiting (CINV) with the introduction of new antiemetic agents, 30–50% of patients receiving moderately or highly emetogenic chemotherapy (MEC or HEC) and guideline directed prophylactic antiemetics develop breakthrough CINV. International guidelines recommend the treatment of breakthrough CINV with an agent from a drug class that was not used in the prophylactic antiemetic regimen and recommend using the breakthrough medication continuously rather than using it on an as needed basis. There have been very few studies on the treatment of breakthrough CINV. A recent double-blind, randomized, phase III study suggested that olanzapine may be an effective agent for the treatment of breakthrough CINV. Refractory CINV occurs when patients develop CINV during subsequent cycles of chemotherapy when antiemetic prophylaxis has not been successful in controlling CINV in earlier cycles. Patients who develop refractory CINV
https://www.hindawi.com/journals/bmri/2015/595894/
Feasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy - Tabular View - ClinicalTrials.govFeasibility of Olanzapine at REduced doSe in hIGHly Emetogenic chemoTherapy - Tabular View - ClinicalTrials.gov
Olanzapine is frequently used off-label as an adjunct antiemetic in clinical oncology settings. North American oncology guidelines recommend it as salvage therapy and as add-on to the standard triple regimen; some suggest it may also be effective as an initial triple therapy (olanzapine replacing the NK-1 antagonist) based on phase II and III trials.. This prospective, multi-center, open-label study aims to evaluate the feasibility of a large scale randomised controlled trial to compare the effectiveness and tolerability of 5mg orally once daily olanzapine in triple antiemetic therapy versus the standard treatment of aprepitant + ondansetron + dexamethasone in treatment-naive patients receiving the first cycle of a highly emetogenic chemotherapy. Secondary outcomes include effectiveness, tolerability and quality of life assessments. Effectiveness will be measured with complete response and complete remission rates in each treatment arms. Tolerability and patient quality of life will be evaluated ...
https://www.clinicaltrials.gov/ct2/show/record/NCT04075955
The efficacy of triplet antiemetic therapy for chemotherapy-induced nausea and vomiting in lung cancer patients receiving...The efficacy of triplet antiemetic therapy for chemotherapy-induced nausea and vomiting in lung cancer patients receiving...
Background Chemotherapy-induced nausea and vomiting (CINV) is one of the most problematic symptoms experienced by patients undergoing cancer treatments. Triplet therapy with PALO, APR, and DEX, is a guideline-recommended antiemetic prophylaxis for highly emetogenic chemotherapy (HEC). However, the efficacy and safety of this therapy for lung cancer patients has not yet been well investigated.. Methods Chemotherapy naïve lung cancer patients scheduled to receive HEC were enrolled in this study. The eligible patients were pretreated with the triplet therapy (PALO 0.75 mg day 1, APR 125 mg day 1 and 80 mg day 2-3, DEX 9.9 mg day 1 and 8 mg day 2-4) before receiving HEC. The efficacy and safety of these substances were assessed during an observation period starting from the administration of HEC to 120 hours. A questionnaire diary documented patients complaints. The primary endpoint was the proportion of the patients who did not experience emesis or rescue antiemetic (Complete Response rate; CR ...
http://oncologypro.esmo.org/Topics/Lung-and-other-Thoracic-Tumours/The-efficacy-of-triplet-antiemetic-therapy-for-chemotherapy-induced-nausea-and-vomiting-in-lung-cancer-patients-receiving-highly-emetogenic-chemotherapy-palonosetron-PALO-aprepitant-APR-and-dexamethasone-DEX
The Efficacy, Safety, and Cost Benefit of Olanzapine versus Aprepitant in Highly Emetogenic Chemotherapy: A Pilot Study from...The Efficacy, Safety, and Cost Benefit of Olanzapine versus Aprepitant in Highly Emetogenic Chemotherapy: A Pilot Study from...
|i|Background|/i|. The efficacy, safety, and cost benefit of olanzapine (OLN) when compared to aprepitant (APR) in the prevention of chemotherapy induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC) were evaluated.|i| Methods|/i|. A prospective pilot study was done in chemotherapy-naive patients receiving HEC to compare OLN versus APR along with palonosetron and dexamethasone. 100 patients consented to the protocol and were randomized and evaluated for Complete Response (CR) (no emesis, no rescue).|i| Results|/i|. CR was 86% for the acute period, 86% for the delayed period, and 80% for the overall period in 50 patients receiving the APD regimen. CR was 84% for the acute period, 88% for the delayed period, and 78% for the overall period for 50 patients receiving the OPD regimen. Patients without nausea were APD: 88% acute, 84% delayed, and 84% overall, and OPD: 84% acute, 88% delayed, and 84% overall.
https://www.hindawi.com/journals/cherp/2016/3439707/
An audit of chemotherapy-induced nausea and vomiting in childrenAn audit of chemotherapy-induced nausea and vomiting in children
Frieda Clinton and colleagues present a study at one childrens cancer centre into the use and effectiveness of anti-emetics for patients receiving chemotherapy An audit was conducted of the management of chemotherapy-induced nausea and vomiting in children and young people in the national Irish paediatric cancer unit. Over three months, the anti-emetic medication and the incidence of nausea and vomiting in 50 consecutive patient episodes were recorded among 25 children receiving chemotherapy for diverse malignancies. Anti-emetic prescription was found to be unrelated to the emetogenic potential of the chemotherapy received, so that effectiveness varied. Dexamethasone was used in only one case. Twenty children did not take any anti-emetics following discharge, although 11 experienced delayed vomiting. evidence-based guidelines were established and now include anti-emetic prescription that is proportional to the emetogenic potential of the chemotherapeutic regimen. It is also recommended that ...
https://aran.library.nuigalway.ie/handle/10379/14806
Risks for Chemotherapy-Induced Nausea and Vomiting: Capturing Relevant Data - JADPRORisks for Chemotherapy-Induced Nausea and Vomiting: Capturing Relevant Data - JADPRO
Abstract. Much of the success achieved in managing the side effects of chemotherapy-induced nausea and vomiting (CINV) centers on the evolving knowledge base regarding the physiology of vomiting. Increasing awareness of multiple afferent pathways from the peripheral gut and the central nervous system to the area of the brain where the common final pathway to the vomiting center is located underpins the development and treatment of CINV with combination antiemetic regimens that target 5-hydroxytryptamine 3, neurokinin-1, and corticosteroid receptors. On the other hand, less is known about the physiologic mechanisms for nausea, which is often more severe and persistent than vomiting after chemotherapy. This article provides a brief overview of the key pathways and neurotransmitters involved in the process of CINV, treatment and patient factors that clinicians must consider in calculating individual patients risks for CINV, and potential assessment tools that accurately document and communicate ...
https://www.advancedpractitioner.com/cme-supplements/volume-5,-supplement-1-
Dronabinol for chemotherapy-induced nausea and vomiting unresponsive t | CMARDronabinol for chemotherapy-induced nausea and vomiting unresponsive t | CMAR
Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics Megan Brafford May,1 Ashley E Glode2 1Department of Pharmacy, Baptist Health Lexington, Lexington, KY, USA; 2Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA Abstract: Chemotherapy-induced nausea and vomiting (CINV) is one of the most common symptoms feared by patients, but may be prevented or lessened with appropriate medications. Several antiemetic options exist to manage CINV. Corticosteroids, serotonin receptor antagonists, and neurokinin receptor antagonists are the classes most commonly used in the prevention of CINV. There are many alternative drug classes utilized for the prevention and management of CINV such as antihistamines, benzodiazepines, anticonvulsants, cannabinoids, and dopamine receptor antagonists. Medications belonging to these classes generally have lower efficacy and are associated with more
https://www.dovepress.com/dronabinol-for-chemotherapy-induced-nausea-and-vomiting-unresponsive-t-peer-reviewed-article-CMAR
A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone...
TY - JOUR. T1 - A randomized, double-blind, parallel, comparative study to evaluate the efficacy and safety of ramosetron plus dexamethasone injection for the prevention of acute chemotherapy-induced nausea and vomiting. AU - Ho, Ching Liang. AU - Su, Wu Chou. AU - Hsieh, Ruey Kuen. AU - Lin, Zhong Zhe. AU - Chao, Tsu Yi. PY - 2009/12/20. Y1 - 2009/12/20. N2 - Objective: To evaluate the efficacy of intravenous ramosetron plus dexamethasone for the prevention of acute chemotherapy-induced nausea and vomiting. Methods: Cancer patients scheduled to receive chemotherapy containing either of the four drugs (cisplatin, doxorubicin, epirubicin or oxaliplatin) were enrolled. They were randomized to receive intravenous ramosetron 0.3 mg plus dexamethasone 20 mg or granisetron 3 mg plus dexamethasone 20 mg 30 min before chemotherapy on day 1. The primary efficacy parameter is complete response rate, which was defined by the proportion of patients without vomiting and no requirement for rescue drugs within ...
https://tmu.pure.elsevier.com/en/publications/a-randomized-double-blind-parallel-comparative-study-to-evaluate-
Combined data from two phase III trials of the NK1 antagonist aprepitant plus a 5HT3 antagonist and a corticosteroid for...Combined data from two phase III trials of the NK1 antagonist aprepitant plus a 5HT3 antagonist and a corticosteroid for...
TY - JOUR. T1 - Combined data from two phase III trials of the NK1 antagonist aprepitant plus a 5HT3 antagonist and a corticosteroid for prevention of chemotherapy-induced nausea and vomiting. T2 - Effect of gender on treatment response. AU - Hesketh, P. J.. AU - Grunberg, S. M.. AU - Herrstedt, J.. AU - De Wit, R.. AU - Gralla, Richard J.. AU - Carides, A. D.. AU - Taylor, A.. AU - Evans, J. K.. AU - Horgan, K. J.. PY - 2006/4. Y1 - 2006/4. N2 - Goals of work: Prevention of chemotherapy-induced nausea and vomiting (CINV) with standard antiemetics has been more difficult to achieve in female patients. Data from two phase III trials of the NK1 antagonist aprepitant were assessed for potential effect of gender on treatment response. Patients and methods: 1,044 patients receiving cisplatin (≥70 mg/m 2) were randomly assigned to control regimen [ondansetron (O) 32 mg i.v. and dexamethasone (D) 20 mg p.o. on day 1; D 8 mg twice daily on days 2-4] or aprepitant (A) regimen (A 125 mg p.o. plus O 32 ...
https://einstein.pure.elsevier.com/en/publications/combined-data-from-two-phase-iii-trials-of-the-nksub1sub-antagoni
Corticosteroids in the Treatment of Chemotherapy-Induced Nausea and Vomiting in: Journal of the National Comprehensive Cancer...Corticosteroids in the Treatment of Chemotherapy-Induced Nausea and Vomiting in: Journal of the National Comprehensive Cancer...
In the highly emetogenic chemotherapy setting, before the introduction of routine combination with NK1 antagonists, when used in combination with a 5HT3 alone, the recommended dose of dexamethasone was 20 mg. A study by the Italian Group for Antiemetic Research evaluated various single intravenous doses of dexamethasone (4, 8, 12, or 20 mg) in combination with ondansetron, 8 mg intravenously in patients receiving cisplatin. Complete protection from acute vomiting and nausea was significantly superior with the 20-mg dose compared with the 4- and 8-mg doses (83.2%/71% vs. 69.2%/60.9% and 69.1%/61%), and superior, but not significantly, to the 12-mg dose (78.5%/66.9%).17 With the introduction of the NK1 antagonists, the triple-drug combination has become the standard of care for highly emetogenic regimens. When this combination is used, the dose of the steroid is reduced to account for the interaction with CYP3A4, which increases the area under the curve of the corticosteroid by approximately 50%. ...
https://jnccn.org/view/journals/jnccn/10/4/article-p493.xml
Dronabinol for Chemotherapy-induced Nausea and Vomiting Unresponsive to Antiemetics - ONADronabinol for Chemotherapy-induced Nausea and Vomiting Unresponsive to Antiemetics - ONA
Abstract: Chemotherapy-induced nausea and vomiting (CINV) is one of the most common symptoms feared by patients, but may be prevented or lessened with appr
http://www.oncologynurseadvisor.com/side-effect-management/dronabinol-for-chemotherapy-induced-nausea-and-vomiting-unresponsive-to-antiemetics/article/504929/
Emesis rate and rescue medication use in children using aprepitant to prevent chemotherapy-induced nausea and vomiting (CINV) |...Emesis rate and rescue medication use in children using aprepitant to prevent chemotherapy-induced nausea and vomiting (CINV) |...
Efficacy and safety were evaluated in 152 aprepitant and 150 control patients. The proportion of patients experiencing no emetic episodes was higher in the aprepitant regimen vs the control regimen during both acute (71.1% vs 53.3%) and delayed (55.3% vs 28.0%) phases. The median time to first vomiting (overall) was significantly longer for aprepitant vs control (94.5 vs 26.0 hours; P < 0.0001). The proportion of patients not requiring rescue medication use was higher for aprepitant vs control (66.4% vs 48.7%), and the time to first rescue medication use was longer for aprepitant vs control (P = 0.0024). Adverse events were similar between regimens and consistent with those in patients undergoing chemo. ...
http://oncologypro.esmo.org/Meeting-Resources/ESMO-2014/Emesis-rate-and-rescue-medication-use-in-children-using-aprepitant-to-prevent-chemotherapy-induced-nausea-and-vomiting-CINV
Antiemetics Market Segmentation and Analysis by Recent Trends, Development and Growth by Regions to 2021 | MedgadgetAntiemetics Market Segmentation and Analysis by Recent Trends, Development and Growth by Regions to 2021 | Medgadget
The Antiemetics market provides detailed market segment level data on the international market. The Antiemetics market report addresses forecast and growth
https://www.medgadget.com/2017/01/antiemetics-market-segmentation-and-analysis-by-recent-trends-development-and-growth-by-regions-to-2021.html
Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory...Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory...
Oliceridine is Associated with Reduced Risk of Vomiting and Need for Rescue Antiemetics Compared to Morphine: Exploratory Analysis from Two Phase 3 Randomized Placebo and Active Controlled Trials
https://adisjournals.figshare.com/articles/media/Oliceridine_is_Associated_with_Reduced_Risk_of_Vomiting_and_Need_for_Rescue_Antiemetics_Compared_to_Morphine_Exploratory_Analysis_from_Two_Phase_3_Randomized_Placebo_and_Active_Controlled_Trials/13150850
Potential role of the NK1 receptor antagonists in chemotherapy-induced nausea and vomiting | Semantic ScholarPotential role of the NK1 receptor antagonists in chemotherapy-induced nausea and vomiting | Semantic Scholar
Abstract. Better tolerated and more effective means of controlling chemotherapy-induced nausea and vomiting have been introduced over the past decade. Despite the progress made, incompletely controlled emesis is a persistent problem for significant numbers of patients receiving chemotherapy. Efforts to improve antiemetic control further are ongoing. The most interesting new class of antiemetics under development focuses on antagonism of the neurotransmitter substance P. Substance P exerts its effects by binding to the tachykinin neurokinin NK1 receptor. A number of selective antagonists of the NK1 receptor have been synthesized and, when used in preclinical models, have demonstrated an ability to antagonize the emetic effects of a number of stimuli, including chemotherapy agents such as cisplatin. Over the past 3 years, results of the initial studies evaluating this class of agents for cisplatin-induced emesis in cancer patients have begun to appear. These agents have been well tolerated. As single
https://www.semanticscholar.org/paper/Potential-role-of-the-NK1-receptor-antagonists-in-Hesketh/34ddc83a85aaea5d83595c6bccab328b0b466986
Emiston
Oral: Moderately emetogenic chemotherapy or radiotherapy: 8 mg 1-2 hours before treatment, then 8 mg every 12 hours for up to 5 days. Severely emetogenic chemotherapy: 8 mg every 12 hours for up to 5 days. Children: 4 mg every 12 hours for up to 5 days. Prevention of postoperative nausea and vomiting: 16 mg 1 hour before anaesthesia followed by 8 mg at 8 hour intervals for 2 further doses.Oral Solution: Prevention of chemotherapy induced nausea & vomiting: Adult: The recommended adult oral dosage is Emiston (Ondasetron) 10 ml oral solution thrice daily in highly emetogenic chemotherapy. In case of moderately emetogenic chemotherapy the oral dose is 10 ml Emiston (Ondasetron) given twice daily. Pediatric Patient: For Pediatric patients 4 through 11 years of age should be given 5 ml oral solution 3 times a day for 1 to 2 days after completion of chemotherapy. Radiotherapy induce nausea and vomiting: The recommended adult oral dosage is Emiston (Ondasetron) 10 ml oral solution thrice daily. Post ...
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Receptor Mechanism And Antiemetic Activity Of Structurally Diverse Cannabinoids | 420 Magazine ®Receptor Mechanism And Antiemetic Activity Of Structurally Diverse Cannabinoids | 420 Magazine ®
Abstract Xenobiotic cannabinoid CB1/CB2-receptor agonists appear to possess broad-spectrum antiemetic activity since they prevent vomiting produced by a...
https://www.420magazine.com/community/threads/receptor-mechanism-and-antiemetic-activity-of-structurally-diverse-cannabinoids.181043/
Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer - Full Text View -...Comparison of Antiemetic Drugs in Preventing Delayed Nausea After Chemotherapy in Patients With Cancer - Full Text View -...
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to center.. Patients receive their scheduled chemotherapy regimen containing doxorubicin and their scheduled oral 5 hydroxytryptamine 3 receptor antagonist antiemetic (ondansetron, granisetron, tropisetron, or dolasetron mesylate) combined with dexamethasone on day 1.. Patients are then randomized to 1 of 3 antiemetic arms.. ...
https://clinicaltrials.gov/ct2/show/NCT00020657
A Retrospective Study of the Effect of Emend (Aprepitant) Combined with Corticosteroids On the Length of Stay in Patients...A Retrospective Study of the Effect of Emend (Aprepitant) Combined with Corticosteroids On the Length of Stay in Patients...
Scott E Mimms, MD, Anna Ibele, MD, Dan McKenna, MD, Lori Blythe, RN, Selzer Don, MD, John Ditslear III, MD, Margaret Inman, MD, Chris Evanson, MD, Samer G Mattar, MD. Clarian North Medical Center. BACKGROUND: Post-operative nausea and vomiting (PONV) is a common complication following LRYGB which can lead to a longer hospital stay. Anti-emetics currently used are not completely effective. Aprepitant, a new class antiemetic, has been shown to reduce the incidence and severity of PONV as well as the length of stay in patients undergoing abdominal and orthopedic surgeries. In combination with corticosteroids and ondansetron, it has been used with good success in reducing the incidence of chemotherapy-induced nausea and vomiting. This study aims to evaluate the effectiveness of Emend ®, in combination with corticosteroids, ondansetron, and metoclopramide, in decreasing the length of stay (LOS) in LRYGB. We selected LOS as a surrogate for serious postoperative nausea and/or dehydration ...
https://www.sages.org/meetings/annual-meeting/abstracts-archive/a-retrospective-study-of-the-effect-of-emend-aprepitant-combined-with-corticosteroids-on-the-length-of-stay-in-patients-undergoing-laparoscopic-roux-en-y-gastric-bypass/
FDA approves Aloxi injection - Hospital Pharmacy EuropeFDA approves Aloxi injection - Hospital Pharmacy Europe
Swiss pharmaceutical group Helsinn Healthcare SA, together with its partner Eisai Corporation of North America and Eisais US subsidiary, MGI Pharma, Inc, have announced that the US Food and Drug Administration (FDA) has approved Aloxi (palonosetron hydrochloride) injection for the prevention of postoperative nausea and vomiting (PONV) for up to 24 hours following surgery. Efficacy beyond 24 hours has not been demonstrated.. Aloxi, available in the US since 2003, is the first and only 5-hydroxytryptamine-3 (5-HT3) receptor antagonist approved by the FDA for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic chemotherapy, and for the prevention of acute nausea and vomiting associated with initial and repeat courses of highly emetogenic chemotherapy.. The new indication is based on one double-blind Phase III study that evaluated the efficacy of three doses of Aloxi compared to placebo for the prevention of PONV. In the trial, ...
https://hospitalpharmacyeurope.com/news/editors-pick/fda-approves-aloxi-injection/
Nausea and Vomiting - Virginia CancerNausea and Vomiting - Virginia Cancer
The best way to treat nausea and vomiting is to prevent it from occurring in the first place. Many new and improved medicines for controlling nausea and vomiting, called antiemetics, have been developed over the last several years. These drugs block the signal in the brain that causes nausea and vomiting. As a result of widespread use of antiemetics, nausea and/or vomiting is not as severe and does not occur as frequently as in the past. There are many different kinds of antiemetics and you may need to try more than one before finding a prescription that works for you.. 5-HT3 inhibitors: The 5HT-3 Inhibitors are the most effective antiemetics and constitute the single greatest advance in the management of nausea and vomiting in patients with cancer. These drugs are designed to block one or more of the signals that cause nausea and vomiting. The most sensitive signal during the first 24 hours after chemotherapy appears to be 5-HT3. Blocking the 5-HT3 signal is one approach to preventing acute ...
https://www.vacancer.com/diagnosis-and-treatment/side-effects-of-cancer/1228-2/
Patient satisfaction with antiemetics correlated with QOL | SpringerLinkPatient satisfaction with antiemetics correlated with QOL | SpringerLink
Patient satisfaction with antiemetics correlated with QOL. Pharmacoecon. Outcomes News 299, 10 (2001). https://doi.org/10.1007/BF03269164. Download ...
https://link.springer.com/article/10.1007%2FBF03269164
Antiemetics Market (Type, Application and Geography) - Size, Share, Global Trends, Company Profiles, Demand, Insights, Analysis...Antiemetics Market (Type, Application and Geography) - Size, Share, Global Trends, Company Profiles, Demand, Insights, Analysis...
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Global Antiemetic Drugs Market 2017-2021: Strong Drug Pipeline to Boost Growth, Reports TechnavioGlobal Antiemetic Drugs Market 2017-2021: Strong Drug Pipeline to Boost Growth, Reports Technavio
According to the latest market study released by Technavio, the global antiemetic drugs marketis expected to grow at a CAGR of more than 6% during the forecast period. This Smart News
http://www.finanznachrichten.de/nachrichten-2017-06/40999604-global-antiemetic-drugs-market-2017-2021-strong-drug-pipeline-to-boost-growth-reports-technavio-004.htm
Results for postoperative nausea and vomiting : ScipediaResults for postoperative nausea and vomiting : Scipedia
Abstract. Postoperative nausea and vomiting (PONV) is one of the most common and distressing adverse events after laparoscopic cholecystectomy (LC). A meta-analysis of randomized clinical trials (RCTs) was performed to determine the efficacy and safety of dexamethasone combined with other antiemetic in the prevention of PONV in patients undergoing LC. A systematic literature search was conducted to identify all relevant RCTs. The primary outcome was PONV in the early period (0-3 hours, 0-4 hours, or 0-6 hours), late period (>6 hours), and the overall period (0-24 hours). Nine RCTs with a total of 1089 patients were included in the analysis. Pooled analysis showed that dexamethasone combined with other antiemetics provided significantly better prophylaxis than single antiemetics in the early period [odds ratio (OR): 0.34, 95% confidence interval (CI): 0.21-0.55, p < 0.001], late period (OR: 0.35, 95% CI: 0.22-0.57, p < 0.001), and the overall period (OR: 0.36, 95% CI: 0.27-0.49, p < 0.001). ...
https://www.scipedia.com/search?q=postoperative+nausea+and+vomiting&search_type=tags
Anzemet - Antiemetics, Serotonin Antagonists, ATC:A04AA04Anzemet - Antiemetics, Serotonin Antagonists, ATC:A04AA04
Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors ...
http://pharmacycode.com/Anzemet.html
A Prospective, Open Label, Non-comparative Trial to Determine the Incidence of Chemotherapy-Induced Nausea and Vomiting (CINV)...A Prospective, Open Label, Non-comparative Trial to Determine the Incidence of Chemotherapy-Induced Nausea and Vomiting (CINV)...
This study will investigate the efficacy and tolerability of aprepitant as add-on therapy to dexamethasone + serotonin-3 receptor antagonists (ondansetron,
http://adisinsight.springer.com/trials/700195011?error=cookies_not_supported&code=da6ebd48-5f2f-49db-adc3-f7722c19a45a
NEWStat | Sponsored: Anti-emetics are standard of care in preventing chemotherapy related vomitingNEWStat | Sponsored: Anti-emetics are standard of care in preventing chemotherapy related vomiting
The use of chemotherapeutic agents for cancer treatment has long been a common approach in treating veterinary patients. Access to more sophisticated diagnostics and treatments have increased over time, and more pet owners are willing to seek advanced care when pets are diagnosed with cancer. Clinicians now have a broader range of options to offer from conventional chemotherapy to radiation therapy to targeted approaches such as the use of tyrosine kinase inhibitors.
http://www.aaha.org/blog/NewStat/post/2016/10/03/858375/Sponsored-Anti-emetics-are-standard-of-care-in-preventing-chemotherapy-related-vomiting.aspx
A multicentre, single-arm, phase II study to investigate the safety and antiemetic efficacy of Akynzeo® (a fixed dose...A multicentre, single-arm, phase II study to investigate the safety and antiemetic efficacy of Akynzeo® (a fixed dose...
1. The first co-primary objective is to explore the safety of an antiemetic regimen consisting of Akynzeo and dexamethasone during five weeks of fractionated (5
http://adisinsight.springer.com/trials/700291757?error=cookies_not_supported&code=416d8239-7a99-48cd-a325-2f14c6b598b5
Aprepitant Oral capsule, Aprepitant Oral capsule - Sterling Care - In-Home Care, Greenwich, CTAprepitant Oral capsule, Aprepitant Oral capsule - Sterling Care - In-Home Care, Greenwich, CT
Aprepitant Oral capsule, Aprepitant Oral capsuleWhat is this medicine?APREPITANT (ap RE pi tant) is used with other medicines to prevent nausea and vomitin
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Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review | The BMJ
This meta-analysis is open to some biases, and they all have the potential to overestimate the efficacy and to underestimate the harm of cannabinoids. The trials we included were of acceptable quality according to the Oxford quality scale, with 25 of 30 trials scoring 3 or 4. In 70% of trials an adequate method of blinding was described. Most crossover trials used a double dummy design. Cannabinoids were given as tablets or intramuscular injection, so any psychological effect of smoking a joint was not a factor. However, cannabinoids showed specific adverse effects that control treatments did not, and their incidence was high. In one trial of oral nabilone, many patients identified which drug they received because of the adverse effects experienced.59 In a series of 100 blinded dronabinol and placebo treatments, nurses correctly identified the active treatment in 85% and patients in 95%; seven of the 10 errors were made by patients on the first drug trial of the study.63 We must therefore assume ...
https://www.bmj.com/content/323/7303/16.full
Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review | The BMJ
This meta-analysis is open to some biases, and they all have the potential to overestimate the efficacy and to underestimate the harm of cannabinoids. The trials we included were of acceptable quality according to the Oxford quality scale, with 25 of 30 trials scoring 3 or 4. In 70% of trials an adequate method of blinding was described. Most crossover trials used a double dummy design. Cannabinoids were given as tablets or intramuscular injection, so any psychological effect of smoking a joint was not a factor. However, cannabinoids showed specific adverse effects that control treatments did not, and their incidence was high. In one trial of oral nabilone, many patients identified which drug they received because of the adverse effects experienced.59 In a series of 100 blinded dronabinol and placebo treatments, nurses correctly identified the active treatment in 85% and patients in 95%; seven of the 10 errors were made by patients on the first drug trial of the study.63 We must therefore assume ...
http://www.bmj.com/content/323/7303/16?view=long&pmid=11440936
5 Tips about Cannabis and Seizures You Can Use Today
An extra look for of the first literature For the reason that critique by Whiting et al. (2015) did not identify any further scientific studies. The key literature was then searched in an effort to obtain experiments of cannabinoids in comparison to the more greatly utilised antiemetics. One trial done in 2007 investigated a cannabinoid therapy as compared to the current generation of serotonin antagonist antiemetics, in contrast to the dopamine D2 receptor antagonists Employed in the sooner trials ...
http://cannabis-and-seizures37924.mybjjblog.com/5-tips-about-cannabis-and-seizures-you-can-use-today-5116662
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Antiemetic Drugs: World Industry and Market Analysis 2014-2024Antiemetic Drugs: World Industry and Market Analysis 2014-2024
Report DetailsTreatments for nausea and vomiting - explore business trends, R&D, and revenue forecastsWhats the future of treating nausea and vomiting? Fo ...
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Aprepitant - شرکت داروسازی البرزبالکAprepitant - شرکت داروسازی البرزبالک
CAS Registry Number: [654671-77-9]. Molecular Formula: C23H21F7N4O3. Molecular Weight: 534.53. Method of Analysis: USP. prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV). ...
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Umesh Laddi | Life-Sciences
In continuation of my update on Varubi (rolapitant) Tesaro, Inc. an oncology-focused biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has approved Varubi (rolapitant) IV in combination with other antiemetic agents in adults for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including, but not limited to, […]. ...
http://life-sciences.blognotions.com/author/uladdi/
Experts Discuss Ways to Remove Barriers to Optimal Management of CINVExperts Discuss Ways to Remove Barriers to Optimal Management of CINV
Despite the widespread availability of antiemetic regimens, between 30% and 50% of patients receiving chemotherapy experience treatment-related nausea and/or vomiting.
http://www.onclive.com/publications/oncology-live/2017/vol-18-no-22/experts-discuss-ways-to-remove-barriers-to-optimal-management-of-cinv
Hyperglycemia and IllnessHyperglycemia and Illness
A 5-year-old girl is brought is by her mother for two days of nausea, vomiting, diarrhea, and fever. She has multiple sick contacts at home with the same. She has no abdominal pain, change in behavior, or rash. The girl is unable to tolerate a PO trial in the ED after antiemetics. Her VS T 39.3 C HR 150 RR 22 BP 98/60. She is well appearing but tired and moderately volume depleted on exam. Her exam is otherwise normal ...
http://www.mededmasters.com/clinical-case-series/hyperglycemia-and-illness
Predni N Tablinen - Neuroprotective Agents, Glucocorticoids, Antiemetics, Anti-inflammatory Agents, ...Predni N Tablinen - Neuroprotective Agents, Glucocorticoids, Antiemetics, Anti-inflammatory Agents, ...
Persons who are on immunosuppressant doses of corticosteroids should be warned to avoid exposure to chicken pox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay.. ...
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Obamas influence has wrecked economyObamas influence has wrecked economy
A Schaumburg letter to the editor: Different. Presidents and their administrations have major influence, and, regrettably, President Obamas has been profoundly negative. He had complete control of Congress for the first two years of his administration and could have, and did do, anything he wanted.
http://www.dailyherald.com/article/20121005/discuss/710059785/
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According to Dr. Hall, this refers to feats where dervishes intentionally cause serious damage to their bodies, yet with complete control over bleeding and infection, and unusually fast wound healing.. The Sacred Promise. ...
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Antiemetics | definition of antiemetics by Medical dictionaryAntiemetics | definition of antiemetics by Medical dictionary
Looking for online definition of antiemetics in the Medical Dictionary? antiemetics explanation free. What is antiemetics? Meaning of antiemetics medical term. What does antiemetics mean?
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Chemotherapy-induced Nausea and Vomiting Drugs Market Trends, Top Manufactures, Market Demands, Industry Growth Analysis &...Chemotherapy-induced Nausea and Vomiting Drugs Market Trends, Top Manufactures, Market Demands, Industry Growth Analysis &...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. The Global CINV Drugs Market to GROW at a CAGR of 5.41% during the period 2017-2021.. Chemotherapy-induced Nausea and Vomiting Drugs Market research report provides granular analysis of the market share, segmentation, revenue forecasts and geographic regions of the market. Chemotherapy-induced Nausea and Vomiting Drugs Market report 2016-2022 focuses on the major drivers and restraints for the key players. The Chemotherapy-induced Nausea and Vomiting Drugs Market research report is a professional and in-depth study on the current state of Chemotherapy-induced Nausea and Vomiting Drugs Market Warming Devices Industry.. Browse more detail information about Chemotherapy-induced Nausea and Vomiting Drugs Market Report at: http://www.absolutereports.com/global-chemotherapy-induced-nausea-and-vomiting-drugs-market-2017-2021-10533708 The launch of extended half-life drugs in the market is expected to substantially ...
http://beforeitsnews.com/health/2017/03/chemotherapy-induced-nausea-and-vomiting-drugs-market-trends-top-manufactures-market-demands-industry-growth-analysis-forecast-2021-2724646.html
Synapse - Double-blind, randomized comparison of the antiemetic efficacy of intravenous dolasetron mesylate and intravenous...
Purpose: To assess the comparative antiemetic efficacy of single-dose intravenous (IV) dolasetron mesylate and ondansetron in preventing cisplatin-induced nausea and vomiting. Patients and Methods: Cancer patients (n = 609) receiving first-course cisplatin chemotherapy were randomized to one of three treatments: 1.8 or 2.4 mg/kg dolasetron mesylate salt (equivalent to 1.3 and 1.8 mg/kg dolasetron base, respectively) or 32 mg ondansetron. Each treatment was infused over 15 minutes, 30 minutes before cisplatin administration. Patients were stratified to cisplatin doses of ,greater than or equal to greater than or equal to 70 and less than 91 mg/m(2) (n = 368) or greater than or equal to 91 mg/m(2) (n = 241), administered over less than or equal to 3 hours, protocol-defined efficacy criteria included complete response (zero emetic episodes and no rescue medication), major response (1 to 2 emetic episodes and no rescue medication), and patients report of nausea severity and satisfaction recorded on ...
https://synapse.mskcc.org/synapse/works/124445
APF530 Superior to Ondansetron in Preventing Chemotherapy-Induced Nausea or Vomiting - The ASCO PostAPF530 Superior to Ondansetron in Preventing Chemotherapy-Induced Nausea or Vomiting - The ASCO Post
As part of a three-drug regimen, APF530 (extended-release formulation of granisetron) has become the first 5-HT3 (5-hydroxytryptamine) receptor antagonist to demonstrate superiority over the standard of care for delayed nausea and vomiting after highly emetogenic chemotherapy. According to the results of the MAGIC trial, presented at the 2015 Breast Cancer Symposium, APF530, administered with fosaprepitant (Emend) and dexamethasone, provided superior complete response in delayed-phase chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy vs a standard-of-care regimen of ondansetron with fosaprepitant plus dexamethasone.1. The APF530 regimen was associated with a clinical benefit over the ondansetron regimen in nausea control, rescue medication use, and patient satisfaction, said Ian D. Schnadig, MD, of Compass Oncology, US Oncology Research, Tualatin, Oregon. It is significant that both arms of the study had a three-drug prophylactic regimen, which has not been ...
http://www.ascopost.com/issues/november-25-2015/apf530-superior-to-ondansetron-in-preventing-chemotherapy-induced-nausea-or-vomiting/
Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer: A prospective...
TY - JOUR. T1 - Chemotherapy-induced nausea and vomiting is less controlled at delayed phase in patients with esophageal cancer. T2 - A prospective registration study by the CINV Study Group of Japan. AU - Baba, Yoshifumi. AU - Baba, Hideo. AU - Yamamoto, Sachiko. AU - Shimada, Hideaki. AU - Shibata, Tomotaka. AU - Miyazaki, Tatsuya. AU - Yoshikawa, Takaki. AU - Nakajima, Yasuaki. AU - Tsuji, Yasushi. AU - Shimokawa, Mototsugu. AU - Kitagawa, Yuko. AU - Aiba, Keisuke. PY - 2017/2/1. Y1 - 2017/2/1. N2 - Chemotherapy is an indispensable therapeutic approach for esophageal cancer. Although chemotherapy-induced nausea and vomiting (CINV) is one of the most crucial adverse events, the current state of CINV in patients with esophageal cancer remains unclear. This multicenter prospective observational study analyzed data for 192 patents with esophageal cancer who underwent moderately emetogenic chemotherapy (MEC) or highly emetogenic chemotherapy (HEC). The patients recorded their CINV incidence and ...
https://keio.pure.elsevier.com/ja/publications/chemotherapy-induced-nausea-and-vomiting-is-less-controlled-at-de
Antiemetic Drugs Industry Sales Research, Key Players, Industry Overview, Supply and Consumption Analysis 2016 - 2021 |...Antiemetic Drugs Industry Sales Research, Key Players, Industry Overview, Supply and Consumption Analysis 2016 - 2021 |...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. Antiemetic Drugs Industry is expected to witness growth of international market with respect to advancements and innovations including development history, competitive analysis and regional development forecast.. The report starts with a basic Antiemetic Drugs Industry overview. In this introductory section, the research report incorporates analysis of definitions, classifications, applications and industry chain structure. Besides this, the report also consists of development trends, competitive landscape analysis, and key regions development status.. The Antiemetic Drugs Industry research report shed light on Foremost Regions like:. North America, Europe, China, Japan, Southeast Asia and India. Application likes Chemotherapy, Pregnancy, Motion Sickness, Food Poisoning, Gastroenteritis and Diziness. Browse Detailed TOC, Tables, Figures, Charts and Companies Mentioned in Antiemetic Drugs Industry Research [email protected] ...
http://beforeitsnews.com/healthcare/2016/10/antiemetic-drugs-industry-sales-research-key-players-industry-overview-supply-and-consumption-analysis-2016-2021-2479532.html
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Concealed Post-Tonsillectomy Haemorrhage Associated with the Use of the Antiemetic Tropisetron | Semantic ScholarConcealed Post-Tonsillectomy Haemorrhage Associated with the Use of the Antiemetic Tropisetron | Semantic Scholar
A two-year-old child experienced concealed haemorrhage after adenotonsillectomy. In our patient, the absence of vomited or significant gastric blood and the presence of melaena stools may partly be attributed to prophylactic antiemetic treatment with tropisetron. This group of patients has a high incidence of postoperative nausea and vomiting, and antiemetic treatment is important and valuable. Rather than advocating the withholding of prophylactic antiemetic treatment, we suggest that whatever medication and techniques are used, good clinical care is dependent on careful postoperative observation and assessment for an appropriate period of time.
https://www.semanticscholar.org/paper/Concealed-Post-Tonsillectomy-Haemorrhage-Associated-Herreen-Wiese/936bad370743a2ae8d0d517a6a9ef34c83f30bc1
Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial....Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial....
Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial. Dolasetron Mesylate PONV Treatment Study Group.
https://scholars.duke.edu/display/pub788815
Clinical Studies and Case ReportsClinical Studies and Case Reports
OBJECTIVE: To compare the efficacy and tolerability of dronabinol, ondansetron, or the combination for delayed chemotherapy-induced nausea and vomiting (CINV) in a 5-day, double-blind, placebo-controlled study. RESEARCH DESIGN AND METHODS: Patients receiving moderately to highly emetogenic chemotherapy received dexamethasone (20 mg PO), ondansetron (16 mg IV) and either placebo or dronabinol (2.5 mg) prechemotherapy on day 1. Patients randomized to active treatment (dronabinol and/or ondansetron) also received dronabinol (2.5 mg) after chemotherapy on day 1. On day 2, fixed doses of placebo, dronabinol (10 mg), ondansetron (16 mg), or combination therapy were administered. On days 3-5, patients received placebo, flexible doses of dronabinol (10-20 mg), ondansetron (8-16 mg), or dronabinol and ondansetron (10-20 mg dronabinol, 8-16 mg ondansetron). MAIN OUTCOME MEASURES: Total response (TR = nausea intensity ,5 mm on visual analog scale, no vomiting/retching, no rescue antiemetic), nausea ...
https://www.cannabis-med.org/studies/ww_en_db_study_show.php?s_id=191&
Most recent papers with the keyword antiemetics in AGE in children | Read by QxMDMost recent papers with the keyword antiemetics in AGE in children | Read by QxMD
PURPOSE: To update the 2009 recommendations for the prevention of acute chemotherapy-induced emesis in children. METHODS: We updated the original systematic literature search. Randomized studies were included in the evidence to support this guideline if they were primary studies fully published in full text in English or French; included only children less than 18 years old or, for mixed studies of adults and children, reported the pediatric results separately or the median or mean age was no more than 13 years; evaluated acute chemotherapy-induced nausea and vomiting (CINV) prophylaxis; provided sufficient information to permit determination of the emetogenicity of the antineoplastic therapy administered or the study investigators stated the emetogenicity of the chemotherapy administered; included an implicit or explicit definition of complete acute CINV response; described the antiemetic regimen in full; and reported the complete acute CINV response rate as a proportion ...
https://www.readbyqxmd.com/keyword/44018
To compare the simplicity and tolerability of two human models used for evaluation of anti-emetic drugs for severe vomitingTo compare the simplicity and tolerability of two human models used for evaluation of anti-emetic drugs for severe vomiting
ABSTRACT. For evaluation of the antiemetic effects of the drugs animal models (Ferret,cat dog etc) are used. Although good guidelines may be established through the animal experiments, they may not give accurate indication of the antiemetic effect of the antiemetic drugs in patients due to species differences in pharmacokinetic and pharmacodynamic responses. Therefore, Ipecacuanha-induced emesis and flare models are used to predict more accurately the antiemetic effect of the antiemetic drugs. In ipecacuanha-induced emesis model in 10 healthy human volunteers slow intravenous injection of ondanserton -2 ml. (4 mg) was given over 5 minutes.Thirty minutes after inj. ondanserton, 30 ml. oral syrup of tincture ipecac was given with glassful of water. Then the parameters like time, number and duration of emesis were noted over 6 hours period. In flare model in 6 healthy human volunteers Injection Serotonin 0.05 ml of 12.98 µM was given intradermally on the flexor aspect of forearm. Resulting flare ...
http://www.ajptr.com/archive/volume-2/december-2012-issue-6/article-465.html
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emetogenicemetogenic
In a phase III study reported in The Lancet Oncology, Schwartzberg et al found that the addition of rolapitant to serotonin (5-HT3) receptor antagonist and dexamethasone treatment significantly improved complete response rates in prevention of chemotherapy-induced nausea and vomiting in patients receiving moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens.. In this double-blind trial, patients from 170 sites in 23 countries were randomly assigned between March 2012 and September 2013 to receive oral rolapitant 180 mg or placebo 1 to 2 hours before the administration of moderately emetogenic chemotherapy. All patients received oral granisetron 2 mg and oral dexamethasone 20 mg on day 1 (except for those receiving taxanes, who received dexamethasone according to the package insert) and granisetron 2 mg on days 2 and 3. Treatment was given for up to six cycles, with a minimum of 14 days…. The investigators concluded: Rolapitant in combination with a 5-HT3 ...
https://www.cancercommons.org/tag/emetogenic/
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Chemotherapy-induced nausea and vomiting - WikipediaChemotherapy-induced nausea and vomiting - Wikipedia
Olanzapine, as well as several other neuroleptic drugs, have also has been investigated for the control of CINV.[12] A 2007 study demonstrated Olanzapines successful potential for this use, achieving a complete response in the acute prevention of nausea and vomiting in 100% of patients treated with moderately and highly emetogenic chemotherapy, when used in combination with palonosetron and dexamethasone.[13] Neuroleptic agents are now indicated for rescue treatment and the control of breakthrough nausea and vomiting.[12]. Some studies[14] and patient groups say that the use of cannabinoids derived from cannabis during chemotherapy greatly reduces the associated nausea and vomiting, and enables the patient to eat. Synthesized tetrahydrocannabinol (also one of the main active substances in marijuana) is marketed as Marinol and may be practical for this application. Natural medical cannabis is also used and recommended by some oncologists, though its use is regulated and it is not legal in all ...
https://en.m.wikipedia.org/wiki/Chemotherapy-induced_nausea_and_vomiting
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Þ rst to demonstrate the antiemetic effects of ondansetron in AGE.[3] Reeves, 2002, also demonstrated the antiemetic properties Review of the literature shows clinicians commonly use and of ondansetron and a decreased hospital admission rate in those prescribe antiemetics for vomiting in children with AGE. A with a serum CO ,15 mEq/L.[14] Ramsook, 2002, was the Þ rst retrospective study of 20,000 children with AGE showed 9% of to compare oral ondansetron to placebo again demonstrating its patients had a prescription Þ lled for an antiemetic. In addition, antiemetic effect and also a decreased need for IVF and hospital 5% of patients under the age of 2 had a prescription Þ lled for admission. SigniÞ cantly higher rates of diarrhea were reported an antiemetic, the most common of which was promethazine in this study related to ondansetron as additional doses of this (Phenergan).[6] A survey of Italian pediatricians reported a 79% medication were given at discharge.[15] In 2006, Freedman ...
http://medpdffinder.com/o/onlinejets.org1.html
Breakthrough Chemotherapy-Induced Nausea & Vomiting: Control... : Oncology TimesBreakthrough Chemotherapy-Induced Nausea & Vomiting: Control... : Oncology Times
In the study (Abstract 9064), 205 patients with a range of tumor types who had not previously received chemotherapy were given standard guideline-recommended drugs to prevent CINV prior to starting highly emetogenic chemotherapy with cisplatin or cyclophosphamide and doxorubicin.. Eighty of the patients developed breakthrough CINV and were randomized in a double-blind manner to receive either olanzapine (10 mg daily for three days) or metoclopramide (10 milligrams three times a day for three days).. Baseline characteristics, including age range (39 to 79 years), percentage of females (about one-fifth), ECOG performance scores (about 31% had scores of 0), and distribution of tumor types (breast, lung, lymphoma, and bladder), were similar between the two groups.. The researchers chose to test olanzapine because physicians treating patients with psychosis made the empirical observation that they appeared to have less nausea and vomiting from other drugs they were on, Navari said.. ...
https://journals.lww.com/oncology-times/Fulltext/2012/06250/Breakthrough_Chemotherapy_Induced_Nausea__.1.aspx
Chemotherapy-induced Nausea and Vomiting (CINV) Treatment Market Insight 2025Chemotherapy-induced Nausea and Vomiting (CINV) Treatment Market Insight 2025
Chemotherapy-induced Nausea and Vomiting (CINV) Treatment Market is driven by rising number of patients undergoing chemotherapy and increasing compliance to chemotherapy drugs due to varied treatment options such as transdermal patches and combination therapies
https://www.transparencymarketresearch.com/chemotherapy-induced-nausea-vomiting-treatment-market.html
Get PDF Natural Remedies for CINV (Chemotherapy-Induced Nausea and Vomiting)
Chemotherapy-Induced Nausea and Vomiting (CINV) After chemotherapy, you may also be given anti-nausea medications to take at home. Its important to.
https://benohaderpha.ml/natural-remedies-for-cinv-chemotherapy-induced-nausea-and.php
ANTIEMETICS | Pharmacological agents | Medicinal PlantsANTIEMETICS | Pharmacological agents | Medicinal Plants
ANTIEMETICS are used to prevent vomiting. They are thus related to antinauseant drugs which are used to reduce or prevent the feeling of nausea that very often precedes the physical process of vomiting (emesis). Commonly, the terms are used synonymously, though it is usually an antinauseant action that is being sought. The type of antinauseant drugs used, and the likelihood of success, depends on the mechanism and origin of the nauseous sensation, and there are a number of ways it can be triggered. Motion sickness (travel sickness) can often be prevented by taking antinauseant drugs before travelling, e.g. the antihistamines meclozine and dimenhydrinate, and the anticholinergic hyoscine. Probably all these drugs act as central MUSCARINIC CHOLINOCEPTOR ANTAGONISTS. Similar drugs may be used to treat nausea and some other symptoms of labyrinthine disease (where the vestibular balance mechanisms of the inner ear are disturbed, e.g. in Menieres disease), though other antinauseant drugs may also be ...
http://medicinalplants.us/antiemetics
Dimenhydrinate - definition of dimenhydrinate by The Free DictionaryDimenhydrinate - definition of dimenhydrinate by The Free Dictionary
Define dimenhydrinate. dimenhydrinate synonyms, dimenhydrinate pronunciation, dimenhydrinate translation, English dictionary definition of dimenhydrinate. n. A drug composed of two chemicals, diphenhydramine and 8-chlorotheophylline, used to prevent motion sickness. n a white slightly soluble bitter-tasting...
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Metoclopramide: Dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy<...Metoclopramide: Dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy<...
TY - JOUR. T1 - Metoclopramide. T2 - Dose-related toxicity and preliminary antiemetic studies in children receiving cancer chemotherapy. AU - Allen, J. C.. AU - Gralla, R.. AU - Reilly, L.. AU - Kellick, M.. AU - Young, C.. PY - 1985/1/1. Y1 - 1985/1/1. N2 - Prior studies in adults have shown that metoclopramide (MCP), when given in high intravenous (IV) doses (2 mg/kg), is a highly effective antiemetic for chemotherapy-induced vomiting. It is well-tolerated in older adults, but younger adults have an increased disposition to acute extrapyramidal reactions (ERPs). Before studying the efficacy of MCP as an antiemetic in children, we first had to establish the safe dose range. We performed a dose-increase MCP toxicity study in children receiving highly emetic chemotherapy such as cisplatin (120 mg/m2) or cyclophosphamide (,900 mg/m2), beginning with a dose of 0.2 mg/kg and increasing the dose in nine steps to 3 mg/kg. MCP was given every two hours for four doses beginning one-half hour before ...
https://einstein.pure.elsevier.com/en/publications/metoclopramide-dose-related-toxicity-and-preliminary-antiemetic-s-2
Antiemetics (Phenothiazines): Healthwise Medical Information on eMedicineHealthAntiemetics (Phenothiazines): Healthwise Medical Information on eMedicineHealth
Learn about the drug Antiemetics (Phenothiazines). Includes generic and brand name examples, dosage, how the drug works, why it is used and side effects.
https://www.emedicinehealth.com/script/main/art.asp?articlekey=129052&ref=129503
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Benign Positional Vertigo in Emergency Medicine Medication: Antiemetic Agents, Antiemetics, Selective 5-HT3 Antagonist,...Benign Positional Vertigo in Emergency Medicine Medication: Antiemetic Agents, Antiemetics, Selective 5-HT3 Antagonist,...
Benign positional vertigo (BPV) is the most common cause of vertigo. Vertigo is an illusion of motion (an illusion is a misperception of a real stimulus) and represents a disorder of the vestibular proprioceptive system.
https://emedicine.medscape.com/article/791414-medication
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Two large retrospective cohort studies of ondansetron use in pregnancy have been published. In one study with 1,349 infants born to women who reported the use of ondansetron or received an ondansetron prescription in the first trimester, no increased risk for major congenital malformations was seen in aggregate analysis. In this same study, however, a sub-analysis for specific malformations reported an association between ondansetron exposure and cardiovascular defect (odds ratio (OR) 1.62 [95% CI (1.04, 2.14)]) and cardiac septal defect (OR 2.05 [95% CI (1.19, 3.28)]). The second study examined 1970 women who received ondansetron prescription during pregnancy and reported no association between ondansetron exposure and major congenital malformations, miscarriage or stillbirth, and infants of low birth weight or small for gestational age. Important methodological limitations with these studies include the uncertainty of whether women who filled a prescription actually took the medication, the ...
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6182c593-4253-0326-e053-2991aa0a4ad0&type=display
Impact of adding therapeutic recommendations to risk assessments from a prediction model for postoperative nausea and vomitingImpact of adding therapeutic recommendations to risk assessments from a prediction model for postoperative nausea and vomiting
Background. In a large cluster-randomized trial on the impact of a prediction model, presenting the calculated risk of postoperative nausea and vomiting (PONV) on-screen (assistive approach) increased the administration of risk-dependent PONV prophylaxis by anaesthetists. This change in therapeutic decision-making did not improve the patient outcome; that is, the incidence ... read more of PONV. The present study aimed to quantify the effects of adding a specific therapeutic recommendation to the predicted risk (directive approach) on PONV prophylaxis decision-making and the incidence of PONV. Methods. A prospective before-after study was conducted in 1483 elective surgical inpatients. The before-period included care-as-usual and the after-period included the directive risk-based (intervention) strategy. Risk-dependent effects on the administered number of prophylactic antiemetics and incidence of PONV were analysed by mixed-effects regression analysis. Results. During the intervention period ...
https://dspace.library.uu.nl/handle/1874/331367
A korean predictive model for postoperative nausea and vomiting.
Postoperative nausea and vomiting (PONV) is one of the most common and distressing complications after surgery. An identification of risk factors associated with PONV would make it easier to select specific patients for effective antiemetic therapy.
http://www.biomedsearch.com/nih/korean-predictive-model-postoperative-nausea/16224155.html
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Clinical Guidelines (Nursing) : Chemotherapy induced nausea and vomitingClinical Guidelines (Nursing) : Chemotherapy induced nausea and vomiting
Chemotherapy induced nausea and vomiting (CINV) is a common and extremely unpleasant side effect for children receiving chemotherapy. CINV can lead to complications of treatment and also cause significant emotional and physical distress, disruptions to activities of daily living and influence the quality of life of the patient. The goal of antiemetic therapy is to prevent vomiting and minimise nausea both during and after the administration of chemotherapy. The severity of nausea and vomiting can, to some degree, be predicted by the chemotherapeutic agents being delivered but there is a degree of variation between patients. Antiemetic treatments should be initiated prior to the first dose of chemotherapy for best control of nausea and vomiting, as it can often become difficult to control nausea once the child is actually vomiting. Non-pharmacological measures are also an important consideration and should be implemented in conjunction with pharmacological regimes to allow for the effective ...
https://www.rch.org.au/rchcpg/hospital_clinical_guideline_index/Chemotherapy_induced_nausea_and_vomiting/
Oral Perphenazine 8 mg: A Low-Cost, Efficacious Antiemetic O... : Anesthesia & AnalgesiaOral Perphenazine 8 mg: A Low-Cost, Efficacious Antiemetic O... : Anesthesia & Analgesia
We congratulate and thank the Fourth Consensus Conference addressing Guidelines for the Management of Postoperative Nausea and Vomiting (PONV).1 We wholeheartedly agree with its one major change in this iteration of the guideline…that in adults, the panel consensus is now to implement multimodal PONV prophylaxis in patients with 1 or 2 risk factors, in an attempt to reduce risk of inadequate prophylaxis. However, since patients with 0 risk factors still have a 10% PONV risk, and because at least 3 nonsedating off-patent inexpensive antiemetics are easily available with minimal side effect burden, we endorse 2 integrated approaches that differ from those presented by the current or previous Consensus Guidelines. First, and principally, we endorse that oral perphenazine 8 mg (OP8) is a low-cost and efficacious tool for prevention of PONV. Second, we will demonstrate the theoretical value of the perphenazine-dexamethasone-ondansetron (P-D-O) technique (OP8, dexamethasone 4 mg intravenous ...
https://journals.lww.com/anesthesia-analgesia/Fulltext/2021/02000/Oral_Perphenazine_8_mg__A_Low_Cost,_Efficacious.47.aspx
Phase II, open label, randomized comparative trial of ondansetron alone versus the combination of ondansetron plus aprepitant...Phase II, open label, randomized comparative trial of ondansetron alone versus the combination of ondansetron plus aprepitant...
The goal of this clinical research study is to compare the effectiveness of receiving a combination of ondansetron and aprepitant to receiving ondansetron alone in helping to prevent nausea and/or vomiting in patients with AML or HR-MDS who are receiving cytarabine. The safety of this drug combination will also be studied.
https://www.mdanderson.org/patients-family/diagnosis-treatment/clinical-trials/clinical-trials-index/clinical-trials-detail.ID2008-0615.html
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Dexamethasone used as an antiemetic in chemotherapy protocols inhibits natural cytotoxic (NC) cell activity. Antiemetic...Dexamethasone used as an antiemetic in chemotherapy protocols inhibits natural cytotoxic (NC) cell activity. Antiemetic...
Dexamethasone used as an antiemetic in chemotherapy protocols inhibits natural cytotoxic (NC) cell activity. Antiemetic superiority of lorazepam over oxazepam and methylprednisolone as premedicants for patients receiving cisplatin-containing chemotherapy
http://www.readabstracts.com/Health/Dexamethasone-used-as-an-antiemetic-in-chemotherapy-protocols-inhibits-natural-cytotoxic-NC-cell-act.html
Akynzeo® | Prevent Chemotherapy-induced Nausea and VomitingAkynzeo® | Prevent Chemotherapy-induced Nausea and Vomiting
AKYNZEO® is an antiemetic prescription medicine used to help prevent the nausea and vomiting caused by some chemotherapy treatments. Talk to your doctor.
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AntiemeticAntiemetic
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness ... Muscimol is purported to have antiemetic activity. Ajwain is purported to be antiemetic. It is a popular spice in India, ... It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT3 receptor antagonists and NK1 ... Emetrol is also claimed to be an effective antiemetic. Propofol is given intravenously. It has been used in an acute care ...
https://en.wikipedia.org/wiki/Antiemetic
5-HT3 antagonist5-HT3 antagonist
The antiemetic effects of metoclopramide were found to be partially because of its serotonin antagonism. While Fozard was ... Unlike antihistamines with antiemetic properties such as cyclizine, 5-HT3 antagonists do not produce sedation, nor do they ... Patients with multiple alleles tend to be unresponsive to the antiemetic drug and vice versa. The history of the 5-HT3 receptor ... Galanolactone, a diterpenoid found in ginger, is a 5-HT3 antagonist and is believed to at least partially mediate the anti- ...
https://en.wikipedia.org/wiki/5-HT3_antagonist
Senna glycosideSenna glycoside
Treatment of Disorders of Bowel Motility and Water Flux; Anti-Emetics; Agents Used in Biliary and Pancreatic Disease.". In ...
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DiphenhydramineDiphenhydramine
... also has antiemetic properties, which make it useful in treating the nausea that occurs in vertigo and motion ... Flake ZA, Scalley RD, Bailey AG (March 2004). "Practical selection of antiemetics". American Family Physician. 69 (5): 1169-74 ... Antiemetics, Deliriants, Enzyme inhibitors, Diphenylmethanol ethers, H1 receptor antagonists, Hypnotics, Local anesthetics, ...
https://en.wikipedia.org/wiki/Diphenhydramine
End-of-life careEnd-of-life care
Nausea and vomiting Typically controlled using haloperidol, metoclopramide, ondansetron, cyclizine; or other anti-emetics. ...
https://en.wikipedia.org/wiki/End-of-life_care
DopamineDopamine
Flake ZA, Scalley RD, Bailey AG (March 2004). "Practical selection of antiemetics". American Family Physician. 69 (5): 1169-74 ...
https://en.wikipedia.org/wiki/Dopamine
List of dopaminergic drugsList of dopaminergic drugs
Zotepine Antiemetics: AS-8112 • Alizapride • Bromopride • Clebopride • Domperidone • Metoclopramide • Thiethylperazine Others: ...
https://en.wikipedia.org/wiki/List_of_dopaminergic_drugs
Serafim GuimarãesSerafim Guimarães
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MetoclopramideMetoclopramide
As a perioperative anti-emetic, the effective dose is usually 25 to 50 mg (compared to the usual 10 mg dose). It is also used ... The antiemetic action of metoclopramide is due to its antagonist activity at D2 receptors in the chemoreceptor trigger zone in ... Derry S, Moore RA (April 2013). "Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in ... At higher doses, 5-HT3 antagonist activity may also contribute to the antiemetic effect.[failed verification] The ...
https://en.wikipedia.org/wiki/Metoclopramide
CyclizineCyclizine
... was introduced to many countries as a common antiemetic. It is an over-the-counter drug in many countries because it ... Cyclizine was quickly clinically found as a potent and long-acting antiemetic. The company named the substance - or more ... The substance received more credit when NASA chose it as a space antiemetic for the first occupied moon flight. ... "Anti-emetics - Metoclopramide, Domperidone, Ondansetron, Cyclizine. - Introduction". Archived from the original on 2 April 2015 ...
https://en.wikipedia.org/wiki/Cyclizine
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Antiemetic "Ipecac Syrup". Discontinued Drug Bulletin.[dead link] Galton L (1966-01-09). "New Lifesaver For Your Medicine Chest ...
https://en.wikipedia.org/wiki/Syrup_of_ipecac
MigraleveMigraleve
"Pfizer official website". Migraleve home page (Antimigraine drugs, Analgesics, Antiemetics). ...
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https://en.wikipedia.org/wiki/Ezlopitant
PremedicationPremedication
... and using antiemetics or antihistamines before chemotherapy. Premedication before chemotherapy for cancer often consists of ...
https://en.wikipedia.org/wiki/Premedication
DomperidoneDomperidone
This led to the discovery of domperidone as a strong antiemetic with minimal central effects. Domperidone was patented in the ... There is some evidence that domperidone has antiemetic activity. It is recommended by the Canadian Headache Society for ... Doggrell SA, Hancox JC (January 2014). "Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue ... Wo JM, McCallum RW, Gonzalez Z (2021). "Antiemetic therapy for gastroparesis". Gastroparesis. Elsevier. pp. 341-359. doi: ...
https://en.wikipedia.org/wiki/Domperidone
Paul Andrews (scientist)Paul Andrews (scientist)
Bermudez, J., Boyle, E. A., Miner,W. D., and Sanger, G. J. (1988). "The anti-emetic potential of the 5-hydroxytryptamine3 ... Clinical reviews indicate selective 5-HT3 receptor antagonists are an essential component of anti-emetic therapy in patients ... Multinational Association for the Support of Cancer Care (MASCC). "MASCC/ESMO Antiemetic Guidelines". Herrstedt, J., Roila, F., ... Collaborating with Gareth Sanger, who demonstrated the anti-emetic efficacy of 5-hydroxytryptamine3 (5-HT3) receptor ...
https://en.wikipedia.org/wiki/Paul_Andrews_(scientist)
DeudomperidoneDeudomperidone
Wo, John M.; McCallum, Richard W.; Gonzalez, Zorisadday (2021). "Antiemetic therapy for gastroparesis". Gastroparesis. Elsevier ... Antiemetics, Antigonadotropins, Benzimidazoles, Chloroarenes, D2 antagonists, D3 antagonists, Deuterated compounds, ...
https://en.wikipedia.org/wiki/Deudomperidone
MaropitantMaropitant
By virtue of working at the last step in triggering vomiting, it can prevent a broader range of stimuli than most antiemetics ... Maropitant is safer than other antiemetics used in veterinary medicine, in part because of its high specificity for its target ... When compared to other anti-emetics, maropitant has similar or greater effectiveness to chlorpromazine and metoclopramide for ... ISBN 978-1-4377-0282-8. Trepanier LA (February 2015). "Maropitant: Novel Antiemetic" (PDF). Clinician's Brief. Retrieved 28 ...
https://en.wikipedia.org/wiki/Maropitant
NauseaNausea
Medications taken to prevent and treat nausea and vomiting are called antiemetics. The most commonly prescribed antiemetics in ... The choice of antiemetic medication may be based on the situation during which the person experiences nausea. For people with ... Other factors to consider when choosing an antiemetic medication include the person's preference, side-effect profile, and cost ... Flake ZA, Linn BS, Hornecker JR (March 2015). "Practical selection of antiemetics in the ambulatory setting". American Family ...
https://en.wikipedia.org/wiki/Nausea
PemetrexedPemetrexed
... 's emetogenic effects are managed with prophylactic antiemetics. Diarrhea Oral mucositis (mouth, throat, or lip sores ...
https://en.wikipedia.org/wiki/Pemetrexed
Bilious vomiting syndromeBilious vomiting syndrome
H2 blockers and antiemetics can also be used. Bilious vomiting syndrome is a diagnosis of exclusion, meaning that the dog is ...
https://en.wikipedia.org/wiki/Bilious_vomiting_syndrome
Megestrol acetateMegestrol acetate
In addition to its effects on appetite, MGA appears to have antiemetic effects. MGA is also used as an antineoplastic agent in ... Loprinzi C, Jatoi A (April 2006). "Antiemetic properties of megestrol acetate". J Palliat Med. 9 (2): 239-40. doi:10.1089/jpm. ... "Antiemetic activity of megestrol acetate in patients receiving chemotherapy". Support Care Cancer. 19 (5): 667-73. doi:10.1007/ ... Antiemetics, Antigonadotropins, Appetite stimulants, Dienes, Diketones, Drugs with unknown mechanisms of action, ...
https://en.wikipedia.org/wiki/Megestrol_acetate
NetupitantNetupitant
... is an antiemetic medication. In the United States, the combinations of netupitant/palonosetron and fosnetupitant/ ... Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively ... Antiemetics, NK1 receptor antagonists, Trifluoromethyl compounds, Piperazines, 2-Tolyl compounds). ...
https://en.wikipedia.org/wiki/Netupitant
Radiation therapyRadiation therapy
Nausea for any reason can be treated with antiemetics. Damage to the epithelial surfaces Epithelial surfaces may sustain damage ...
https://en.wikipedia.org/wiki/Radiation_therapy
Bowel obstructionBowel obstruction
Antiemetics may be administered if the patient is vomiting. Adhesive obstructions often settle without surgery. If the ...
https://en.wikipedia.org/wiki/Bowel_obstruction
VomitingVomiting
An antiemetic is a drug that is effective against vomiting and nausea. Antiemetics are typically used to treat motion sickness ... and cannabinoids are used as antiemetics. Evidence to support the use of antiemetics for nausea and vomiting among adults in ... Antiemetics are sometimes necessary to suppress nausea and vomiting. Self-induced vomiting can be a component of an eating ... and the side effects of medications such as opioids and chemotherapy.[citation needed] Antiemetics act by inhibiting the ...
https://en.wikipedia.org/wiki/Vomiting
LeonurineLeonurine
Theriot, Jonathan; Wermuth, Harrison R.; Ashurst, John V. (2022). "Antiemetic Serotonin-5-HT3 Receptor Blockers". StatPearls. ...
https://en.wikipedia.org/wiki/Leonurine
DronabinolDronabinol
It has indications as an appetite stimulant, antiemetic, and sleep apnea reliever and is approved by the FDA as safe and ... "Dronabinol for chemotherapy-induced nausea and vomiting unresponsive to antiemetics". Cancer Management and Research. Informa ... Antiemetics, AbbVie brands, Appetite stimulants, Aromatase inhibitors, Benzochromenes, Entheogens, Euphoriants, ...
https://en.wikipedia.org/wiki/Dronabinol
OlanzapineOlanzapine
... has been recommended to be used in antiemetic regimens in people receiving chemotherapy that has a high risk for ... October 2017). "Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update". Journal of Clinical ... Olanzapine has been studied as an antiemetic, particularly for the control of chemotherapy-induced nausea and vomiting (CINV). ... Schwartzberg L (March 2018). "Getting it right the first time: recent progress in optimizing antiemetic usage". Supportive Care ...
https://en.wikipedia.org/wiki/Olanzapine
Pediatric Dehydration Medication: AntiemeticsPediatric Dehydration Medication: Antiemetics
Antiemetics. Class Summary. Use a single dose of oral ondansetron in combination with oral rehydration for patients with ... 12, 15, 16] However, the use of an antiemetic should not shift the focus away from adequate fluid resuscitation. ... Alhashimi D, Alhashimi H, Fedorowicz Z. Antiemetics for reducing vomiting related to acute gastroenteritis in children and ...
https://www.medscape.com/answers/801012-80861/which-medications-in-the-drug-class-antiemetics-are-used-in-the-treatment-of-pediatric-dehydration
Pediatric Dehydration Medication: AntiemeticsPediatric Dehydration Medication: Antiemetics
Antiemetics. Class Summary. Use a single dose of oral ondansetron in combination with oral rehydration for patients with ... 12, 15, 16] However, the use of an antiemetic should not shift the focus away from adequate fluid resuscitation. ... Alhashimi D, Alhashimi H, Fedorowicz Z. Antiemetics for reducing vomiting related to acute gastroenteritis in children and ...
https://emedicine.medscape.com/article/801012-medication
BONINE® MECLIZINE HYDROCHLORIDE • ANTIEMETICBONINE® MECLIZINE HYDROCHLORIDE • ANTIEMETIC
Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.. ----------. ...
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=0b4b55cd-063e-4d0e-911c-8e03886e15d3&type=display
Illustrated Glossary of Organic Chemistry - AntiemeticIllustrated Glossary of Organic Chemistry - Antiemetic
Molecular structure of thalidomide, an antiemetic prescribed to pregnant women in the late 1950s and early 1960s but ... Molecular structure of dexamethasone, a steroidal antiemetic given to counteract nausea and vomiting associated with general ...
http://www.chem.ucla.edu/~harding/IGOC/A/antiemetic.html
Antiemetic/Antinausea NCLEX questions Flashcards | QuizletAntiemetic/Antinausea NCLEX questions Flashcards | Quizlet
Start studying Antiemetic/Antinausea NCLEX questions. Learn vocabulary, terms, and more with flashcards, games, and other study ... Combining antiemetic drugs from various categories allows the blocking of the vomiting center and chemoreceptor trigger zone ( ... C. I should take my prescribed antiemetic before receiving my chemotherapy dose.. D. I will apply the scopolamine patch to ... Which client statement indicates the need for further teaching about antiemetic medications?. A. I may take Tylenol to treat ...
https://quizlet.com/578547311/antiemeticantinausea-nclex-questions-flash-cards/
Antiemetic drugs: what to prescribe and whenAntiemetic drugs: what to prescribe and when
Most cases of nausea and vomiting do not require antiemetic drugs, but when they are needed, what are the choices? ... Classes of antiemetics. The various classes of antiemetics target different pro-emetic pathways to alleviate nausea and ... Haloperidol prolongs the QT interval at cumulative intravenous doses as low as 2 mg,57 but the usual antiemetic dose is 1 mg.4 ... The role of antiemetics to manage opioid-induced nausea and vomiting is poorly defined. Evidence is lacking and confounded by ...
https://www.nps.org.au/australian-prescriber/articles/antiemetic-drugs-what-to-prescribe-and-when
What should I avoid while taking Aloxi? | Antiemetic - SharecareWhat should I avoid while taking Aloxi? | Antiemetic - Sharecare
Aloxi (palonosetron) interacts with many medications. For example, when taken with apomorphine, Aloxi can cause an unsafe drop in blood pressure that
https://www.sharecare.com/health/antiemetic-nausea-vomiting/what-avoid-while-taking-aloxi
Antiemetic Agents - PubMedAntiemetic Agents - PubMed
Antiemetics are rare causes of liver injury, partially because t … ... Antiemetics are used for the symptomatic management of nausea and vomiting that can be caused by a variety of medical ... Antiemetic Agents No authors listed In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. ... The safety of antiemetic medications for the prevention of chemotherapy-induced nausea and vomiting. Navari RM. Navari RM. ...
https://pubmed.ncbi.nlm.nih.gov/31643401
Which medications in the drug class Antiemetic, Serotonin Antagonist are used in the treatment of Dehydration in Children?Which medications in the drug class Antiemetic, Serotonin Antagonist are used in the treatment of Dehydration in Children?
Antiemetic, Serotonin AntagonistIn an emergency department study, ondansetron was shown to decrease likelihood of vomiting, ... Antiemetic, Serotonin Antagonist. In an emergency department study, ondansetron was shown to decrease likelihood of vomiting, ... Which medications in the drug class Antiemetic, Serotonin Antagonist are used in the treatment of Dehydration in Children?. ...
https://www.medscape.com/answers/906999-75562/which-medications-in-the-drug-class-antiemetic-serotonin-antagonist-are-used-in-the-treatment-of-dehydration
Are Antiemetic Prophylactics Being Overprescribed for Chemotherapy? - MPRAre Antiemetic Prophylactics Being Overprescribed for Chemotherapy? - MPR
Concerns have been raised for the use of antiemetic prophylactics for chemotherapy patients with low emetic risk ... Not many studies have looked at antiemetic prophylaxis or treatment associated with chemotherapy with lower emetic risk. The ... 33.7%). The study authors also calculated a cost of approximately $1.6 million for antiemetic prophylaxis for these patients. ... In order to characterize the pattern of overprescribing prophylactic antiemetics to patients who have received intravenous (IV ...
https://www.empr.com/home/news/are-antiemetic-prophylactics-being-overprescribed-for-chemotherapy/
Antiemetics, Selective 5-HT3 Antagonist | Drug, OTCs & Herbals | Medscape ReferenceAntiemetics, Selective 5-HT3 Antagonist | Drug, OTCs & Herbals | Medscape Reference
Antiemetics, Selective 5-HT3 Antagonist: Dosing, Uses, Side Effects, Interactions, Patient Handouts, Pricing and more from ...
https://reference.medscape.com/drugs/antiemetics-selective-5-ht3-antagonist
lies.com » rainbowterrarist: mugsandpugs: antiemetic: rainbowterrarist: antiemetic: slit laughing is…lies.com » rainbowterrarist: mugsandpugs: antiemetic: rainbowterrarist: antiemetic: slit laughing is…
Reposted from http://ift.tt/1eVuW09.. Tags: fury road, slit.. This entry was posted by jbc on Saturday, June 6th, 2015 at 6:11 pm and is filed under Tumblr. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site. ...
http://www.lies.com/wp/2015/06/06/rainbowterrarist-mugsandpugs-antiemetic-rainbowterrarist-antiemetic-slit-laughing-is/
Antiemetic Agents - LiverTox - NCBI BookshelfAntiemetic Agents - LiverTox - NCBI Bookshelf
Antiemetics are rare causes of liver injury, partially because they are used in low doses and for a short time only. ... Antiemetics are used for the symptomatic management of nausea and vomiting that can be caused by a variety of medical ... Antiemetics are rare causes of liver injury, partially because they are used in low doses and for a short time only. ... Antiemetics are used for the symptomatic management of nausea and vomiting that can be caused by a variety of medical ...
https://www.ncbi.nlm.nih.gov/books/n/livertox/AntiemeticAgents/
Global Antiemetics And Antinauseants Market Data And Industry Growth AnalysisGlobal Antiemetics And Antinauseants Market Data And Industry Growth Analysis
Global Antiemetics And Antinauseants Market by The Business Research Company is segmented as Dopamine antagonists; NK1 receptor ... The antiemetics and antinauseants market consists of sale of antiemetic and antinauseant drugs and related services. Antiemetic ... South Korea Antiemetics And Antinauseants Market 14.1. South Korea Antiemetics And Antinauseants Market, Segmentation By Drug, ... UK Antiemetics And Antinauseants Market 16.1. UK Antiemetics And Antinauseants Market, Segmentation By Drug, Historic and ...
https://www.thebusinessresearchcompany.com/report/antiemetics-and-antinauseants-global-market-report
KAKEN - Research Projects | The Shivering Threshold with various antiemetics in Rabbits. (KAKENHI-PROJECT-25462428)KAKEN - Research Projects | The Shivering Threshold with various antiemetics in Rabbits. (KAKENHI-PROJECT-25462428)
On the other hand, since nausea and vomit often happens, there are a lot of chances to administrate antiemetic in perioperative ... Droperidol and Travelmin® are usually used as an antiemetic in perioperative period. Travelmin® is composed of ...
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25462428/
Phase II Trial Testing the Antiemetic Efficacy of a Single-day Low Dose Aprepitant (or Fosaprepitant) Added to a 5-HT3 Receptor...Phase II Trial Testing the Antiemetic Efficacy of a Single-day Low Dose Aprepitant (or Fosaprepitant) Added to a 5-HT3 Receptor...
Phase II Trial Testing the Antiemetic Efficacy of a Single-day Low Dose Aprepitant (or Fosaprepitant) Added to a 5-HT3 Receptor ...
https://www.montefiore.org/body.cfm?id=2342&action=detail&ref=1698
RePub, Erasmus University Repository: The oral NK1 antagonist, aprepitant, given with standard antiemetics provides...RePub, Erasmus University Repository: The oral NK1 antagonist, aprepitant, given with standard antiemetics provides...
Antiemetic, Aprepitant, Cancer, Nausea and vomiting, NK1 antagonist, Supportive care Persistent URL doi.org/10.1016/j.ejca. ... To further study the sustainment of antiemetic efficacy of aprepitant plus standard therapy over more than one cycle of ... The oral NK1 antagonist, aprepitant, given with standard antiemetics provides protection against nausea and vomiting over ... given with standard antiemetics provides protection against nausea and vomiting over multiple cycles of cisplatin-based ...
https://repub.eur.nl/pub/66398
Doblin RE, Kleiman MA.. Marijuana as antiemetic medicine: a survey of oncologists experiences and attitudes. J Clin Oncol 1991...Doblin RE, Kleiman MA.. Marijuana as antiemetic medicine: a survey of oncologists' experiences and attitudes. J Clin Oncol 1991...
Doblin RE, Kleiman MA.. Marijuana as antiemetic medicine: a survey of oncologists experiences and attitudes. J Clin Oncol 1991 ... was conducted in spring 1990 measuring the attitudes and experiences of American oncologists concerning the antiemetic use of ...
https://maps.org/research-archive/mmj/doblin1990-a.html
News for Medical Independent Sales Representatives and Medical Distributors: FDA Approves EMEND(R) (aprepitant), in Combination...News for Medical Independent Sales Representatives and Medical Distributors: FDA Approves EMEND(R) (aprepitant), in Combination...
... in Combination with Other Antiemetics, for the Prevention of Nausea and Vomiting in Cancer Patients Undergoing Moderately ... Healthcare Industry News: antiemetic Biopharmaceuticals FDA News Release - January 11, 2006. FDA Approves EMEND(R) (aprepitant ... antiemetic. s, is also approved for the prevention of nausea and vomiting caused by initial and repeat courses of highly ... antiemetic. effectiveness for the patients receiving the regimen including EMEND was maintained during all cycles.. In Cycle 1 ...
https://salesandmarketingnetwork.com/news_release_bs.html?pipe=0000ac177000191&ID=2009453&key=antiemetic
10/2021: Medicare: Prior authorization required for oncology anti-emetics | UHCprovider.com10/2021: Medicare: Prior authorization required for oncology anti-emetics | UHCprovider.com
Medicare: Prior authorization required for oncology anti-emetics. Effective Jan. 3, 2022, 4 anti-emetic drugs will require ... You dont have to request a prior authorization if the member received these anti-emetic drugs between Oct. 1, 2021, and Jan. 2 ... 10/2021: Medicare: Prior authorization required for oncology anti-emetics * 10/2021: New York: Update to injectable cancer ... Aloxi® (palonosetron), Emend®, Kytril® (granisetron) and Zofran® (ondansetron) will be preferred anti-emetic products. The ...
https://www.uhcprovider.com/en/resource-library/news/2021-network-bulletin-featured-articles/1021-med-adv-oncology-anti-emetics-prior-auth.html
Antiemetics - almostadoctorAntiemetics - almostadoctor
Antiemetic Therapy. *Several different classes of antiemetics are available.. *Each have a slightly different efficacy and side ... Antiemetics are widely used on a daily basis both in and out of hospital. Nausea is a common symptom that you will be expected ... Using Antiemetics. Now that weve learnt all about the cause of nausea, and the different drug classes available, its easier ... Weak anti-emetic on own but useful synergist when given with 5HT3 receptor antagonists or some dopamine receptor antagonists. ...
https://almostadoctor.co.uk/encyclopedia/antiemetics
Diabetic Gastroparesis: Principles and Current Trends in Management | SpringerLinkDiabetic Gastroparesis: Principles and Current Trends in Management | SpringerLink
Antiemetics. Nausea and vomiting are the most disabling symptoms of gastroparesis, and antiemetic agents without stimulatory ... Like prokinetics, the choice of antiemetic is empirical [71]. Some anti-emetics have the potential for KEG Q-Tc prolongation, ... Antihistamines act on H1 receptors to produce central antiemetic effects. Commonly prescribed antiemetics include ... Antiemetic medications act on a broad range of distinct receptors subtypes in the peripheral and central nervous system. ...
https://link.springer.com/article/10.1007/s13300-018-0454-9
Antiemetics | Profiles RNS
"Antiemetics" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Antiemetics" by people in this website by year, and whether " ... Below are the most recent publications written about "Antiemetics" by people in Profiles. ...
https://researchers.childrensmercy.org/display/3604
antiemetic Archives - Green Cairoantiemetic Archives - Green Cairo
Green Cairo, Door No: V.P.II - 137 ...
https://greencairoindia.com/product-tag/antiemetic/
Antiemetics Archives - MedsZoo AntiemeticsAntiemetics Archives - MedsZoo Antiemetics
GIT Regulators, Antiflatulents & Anti-Inflammatories , Antiemetics. *GIT Regulators, Antiflatulents & Anti-Inflammatories , ...
https://www.medszoo.com/product-category/antiemetics/
Antiemetics - Pharmaceuticals - All ProductsAntiemetics - Pharmaceuticals - All Products
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser. ...
https://supply.unicef.org/all-materials/pharmaceuticals/antiemetics.html
Antiemetics | DREAMZ MEDICAL EDUTECH
Anticholinergic Drugs to Avoid in the Elderly - Drugs.comAnticholinergic Drugs to Avoid in the Elderly - Drugs.com
Antiemetics. *prochlorperazine (Compazine). *promethazine (Phenergan). See Also:. *Top 5 Ways to Avoid Drug Errors ...
https://www.drugs.com/article/anticholinergic-drugs-elderly.html
'Infuriating' Rx Denial Leaves Patient Without...
Cite this: Infuriating Rx Denial Leaves Patient Without Antiemetics - Medscape - Feb 16, 2023. ...
http://www.staging.medscape.com/viewarticle/988370
BONINE® MECLIZINE HYDROCHLORIDE • ANTIEMETICBONINE® MECLIZINE HYDROCHLORIDE • ANTIEMETIC
Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.. ----------. ...
https://www.dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=0b4b55cd-063e-4d0e-911c-8e03886e15d3&type=display
NauseaAnalgesicsMetoclopramideChemotherapyProphylaxisOndansetronIntravenousProton Pump InhibDrugsMedicationsEfficacy2022RegimensHigher dosesPostoperativeGastroprokineticTherapeuticSELECTIVEMedicationReceptorsNabiloneTherapyAgentsPeripherallyRescueTabletAdditionTreatmentSurgeryPatientsIncidenceCancerResultsResearch
Nausea22
  • Strict quantity limits on antiemetics for home management of chemotherapy-induced nausea and vomiting are "inappropriate" and make no sense since most are available as generics for less than $10 a month, they add. (medscape.com)
  • Perhaps in a move to limit spending on newer antiemetics, payers have inadvertently put limits on products that aren't expensive anymore, or maybe they mistake the 3-day, 9-pill ondansetron prophylactic regimen as meaning that patients only need 9 tablets a month, which isn't enough to cover breakthrough nausea and vomiting. (medscape.com)
  • Antiemetics can be used to counter the nausea and vomiting that may accompany testicular torsion. (medscape.com)
  • Antiemetic selective serotonin receptor (5-HT3) antagonists (also called serotonin blockers) are a class of medications used to prevent or treat nausea and vomiting in children and adults related to chemotherapy use and radiation therapy and the effects of postoperative anesthesia . (rxlist.com)
  • Antiemetics are a diverse group of drugs used to treat or prevent nausea and vomiting, including that associated with cancer therapy, anaesthesia and surgery, and motion sickness. (obaid.info)
  • An antiemetic is a drug that is effective against vomiting and nausea. (pallipedia.org)
  • Alizapride is a dopamine antagonist with prokinetic and antiemetic effects, used in the treatment of nausea and vomiting. (amitahc.com)
  • Antiemetic use for nausea and vomiting in adult emergency department patients: randomized controlled trial comparing ondansetron, metoclopramide, and placebo. (emergencymedicinekenya.org)
  • Antiemetic drugs are used to treat nausea and vomiting that are caused by other medications. (thechemist247.com)
  • Antiemetic medications are frequently used to treat motion sickness, which can include headaches, nausea, and diarrhoea. (thechemist247.com)
  • Antiemetics come in a variety of forms that can help with nausea, but most of them require a medical examination and prescription. (thechemist247.com)
  • Antiemetics are given to help treat nausea and vomiting that may be caused by chemotherapy, radiation therapy, or surgery to treat cancer. (epnet.com)
  • Antiemetic Drugs may also be used to treat nausea and vomiting caused by other medications, frequent motion sickness, infections, or stomach flu. (365chemists.com)
  • Antihistamines have mild antiemetic activity and are commonly used for motion sickness and the transient nausea. (365chemists.com)
  • Study type: Single centre RCT from Oregon, USA, of acupuncture in addition to routine antiemetic prophylaxis, for postoperative nausea and vomiting (PONV) in children having adenotonsillectomy. (spanza.org.au)
  • Acupuncture in addition to antiemetic prophylaxis may reduce early nausea (not vomiting) according to the results, but by POD1 there is no difference. (spanza.org.au)
  • In conclusion, acustimulation with the ReliefBand® was most effective in reducing postoperative nausea and vomiting and improving patients' satisfaction with their antiemetic therapy when it was administered after surgery. (elsevier.com)
  • The cannabinoids nabilone (Cesamet) and dronabinol (Marinol) are indicated for the management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients who have failed to respond adequately to conventional antiemetic therapy. (nih.gov)
  • The THC, in particular, in marijuana and vomiting treatment is an antiemetic, meaning it's a treatment for relieving vomiting and nausea. (marijuanadoctors.com)
  • Variables collected: age, body surface area, dose carboplatin, chemotherapy (CT) received, antiemetic prophylaxis, nausea and vomiting (N-V) experienced and dose reductions. (ilaphar.org)
  • Of those who had received high doses of the drug (22), 9 (41%) suffered from nausea and 6 (27%) vomiting, which gave partially or totally with taking antiemetics. (ilaphar.org)
  • Pharmacogenetics of antiemetics for chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis. (cdc.gov)
Analgesics1
  • Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy. (pallipedia.org)
Metoclopramide3
  • IMSEAR at SEARO: Comparison of dexamethasone and metoclopramide as antiemetics in children receiving cancer chemotherapy. (who.int)
  • Available antiemetics, such as phenothiazines (chlorpromazine and prochlorperazine) and substituted benzamides (metoclopramide), were known to affect these receptors, as were butyrophenones (haloperidol and droperidol). (cancernetwork.com)
  • The improved antiemetic activity of higher doses of metoclopramide was not explained by its dopamine-binding properties but by the fact that it also affects serotonin receptors. (cancernetwork.com)
Chemotherapy1
  • The CINV caused by chemotherapy treatments is cured by using antiemetic and antinauseant drugs like Dolasetron (Anzemet), Ranitidine (Zantac), and other serotonin 5-HT3 receptor types of antagonists. (thebusinessresearchcompany.com)
Prophylaxis4
  • Antiemetic Prophylaxis for Office-based Surgery: Are the 5-HT3Receptor Antagonists Beneficial? (asahq.org)
  • Antiemetic prophylaxis of carboplatin in ovarian cancer, moderate or highly emetogenic? (ilaphar.org)
  • Purpose: To assess the adequacy of antiemetic prophylaxis in patients with ovarian cancer treated with carboplatin depending on the dose received (lower or higher than 300 mg/m2). (ilaphar.org)
  • All patients received the same antiemetic prophylaxis: dexamethasone 8 mg and ondansetron 8 mg intravenous administration the same day of the cycle (day 1). (ilaphar.org)
Ondansetron1
  • We designed this study to evaluate the antiemetic efficacy of transcutaneous electrical acupoint stimulation in combination with ondansetron when applied before, after, or both before and after plastic surgery. (elsevier.com)
Intravenous1
  • Use this page to view details for the local coverage article for oral antiemetic drugs (replacement for intravenous antiemetics) - policy article. (naplesrealestateandgolf.com)
Proton Pump Inhib1
  • She was treated with proton pump inhibitors and antiemetics. (cdc.gov)
Drugs12
  • The antiemetics and antinauseants market consists of the sale of antiemetic and antinauseant drugs and related services. (thebusinessresearchcompany.com)
  • Lack of awareness about the variety of antiemetic and antinauseant drugs that are available in the market among the practitioners restrains the market. (thebusinessresearchcompany.com)
  • For example, the American Society of Clinical Oncology released its first guideline in the 'Choosing Wisely' (CW) campaign to prevent and discourage the overuse of expensive and similar kinds of antiemetic drugs for all ailments. (thebusinessresearchcompany.com)
  • Antiemetic drugs are delivered to the customer's best product at the cheapest price. (thechemist247.com)
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  • Apart from these cases of specific etiology, readers are informed that antidiarrhoeal drugs and antiemetics should never be used for children, as none has any proven practical value and some are frankly dangerous. (who.int)
Medications4
  • Always buy antiemetic medicine from the https://thechemist247.com.This online pharmacy's website is designed in such a way that a person may get medications with only one click. (thechemist247.com)
  • Rolapitant is in a class of medications called antiemetics. (medlineplus.gov)
  • Other OTC antiemetic medications are available to settle your stomach, but aren't as effective. (marijuanadoctors.com)
  • Dr. Godfrey recommended Melvin be hospitalized and treated IV fluids, an antiemetic (a medication used to stop vomiting), antacids and pain medications. (amadorvalleyvetcenter.com)
Efficacy1
  • Molecular studies have suggested that mutation of the 5-HT 3B receptor subunit may affect antiemetic efficacy. (cancernetwork.com)
20221
  • Cite this: Oncologists Frustrated Over Limits on Low-Cost Antiemetics - Medscape - May 26, 2022. (medscape.com)
Regimens1
Higher doses1
  • Meanwhile, to counter quantity limits, oncologists are sending patients to discount drug websites like GoodRX and prescribing higher doses of antiemetics and asking patients to split pills. (medscape.com)
Postoperative1
  • Finally, patient satisfaction with the quality of recovery (83 ± 16 and 85 ± 13 vs 72 ± 18) and antiemetic management (96 ± 9 and 94 ± 10 vs 86 ± 13) on an arbitrary scale from 0 = worst to 100 = best was significantly higher in the groups receiving peri- or postoperative (versus preoperative) acustimulation therapy. (elsevier.com)
Gastroprokinetic2
Therapeutic1
  • Manufacturers are exploiting nanotechnology in the antiemetics and antinauseants market to deliver therapeutic agents to specifically targeted sites in a controlled manner through Nanomedicine and Nano delivery systems. (thebusinessresearchcompany.com)
SELECTIVE1
  • How Do Antiemetic Selective 5-HT3 Antagonist Work? (rxlist.com)
Medication1
  • The widespread self-medication with cannabis as an antiemetic agent during early pregnancy raises the question of whether its benefits overweigh the risks. (techsling.com)
Receptors2
  • For many years, the dopamine receptors were the main focus of interest in antiemetic research. (cancernetwork.com)
  • Allergamin (ALLERGAMINE) 100ml e is an effective antihistamine antagonist of histamine H1 receptors, which has anti-cholinergic, antiemetic, antitussive, and sedative properties. (firsthorsevetcare.com)
Nabilone3
  • The use of some antiemetics such as dronabinol and nabilone has been associated with occasional hypotension, possible hypertension, syncope or tachycardia. (drugs.com)
  • Some antiemetics such as dronabinol and nabilone may precipitate or exacerbate psychotic symptoms or anxiety, depression, hallucinations or psychosis. (drugs.com)
  • Some antiemetics as dronabinol and nabilone have a significant potential for abuse. (drugs.com)
Therapy2
  • Other outcome variables assessed included discharge times (for outpatients), resumption of normal activities of daily living, complete antiemetic response rate, and patient satisfaction with antiemetic therapy and quality of recovery. (elsevier.com)
  • Conclusions: The dose of carboplatin received could be decisive when assessing strengthen antiemetic therapy. (ilaphar.org)
Agents1
  • Un échantillon de 150 agents de soins de santé dans des maisons de santé et de 150 pharmaciens en milieu hospitalier ou communautaire ont répondu au questionnaire évaluant leurs connaissances sur l'utilisation correcte des pilules contraceptives, les effets secondaires, les contre-indications, les signes de danger/symptômes et les avantages non-contraceptifs, mais aussi sur l'offre ou non de conseils aux patientes en la matière. (who.int)
Peripherally1
  • It is not certain whether ondansetron's antiemetic action is mediated centrally, peripherally, or in both sites. (naplesrealestateandgolf.com)
Rescue1
  • The incidence of vomiting/retching and the need for rescue antiemetics were determined at specific time intervals for up to 72 h after surgery. (elsevier.com)
Tablet1
  • Ondamac 4mg Tablet MD Ondem-MD 4 tablet is an antiemetic medicine. (365chemists.com)
Addition3
  • In addition to its antiemetic effects, it has the advantage of augmenting hypoxic ventilatory response, acting as a respiratory stimulant at high altitude. (medscape.com)
  • This dosage is followed by Emend (80 mg orally) on Days 2 and 3 in a three-day antiemetic regimen, in addition to a corticosteroid and a 5-HT3 antagonist. (drugtopics.com)
  • There is an evidence base for the use of P6 acupuncture for early PONV in adults, and in children compared to no antiemetics, but this is the first study in children using acupuncture in addition to antiemetics. (spanza.org.au)
Treatment1
  • unless no other antiemetics are available, this antiemetic should not be used to treat vomiting associated with the use of atovaquone at treatment doses. (cdc.gov)
Surgery2
  • After bariatric surgery (Roux-en-Y), patients become vulnerable to decreased secretion of gastric acid, achlorhydria and malabsorption of proteins, iron, vitamin B12 and folic acid 2 . (bvsalud.org)
  • We analysed the cases of two patients, submitted to Roux-en-Y gastric bypass bariatric surgery (BS). (bvsalud.org)
Patients2
  • Oncologists are calling on health insurance companies and pharmacy benefit managers to end quantity limits on low-cost generic antiemetics for patients with cancer. (medscape.com)
  • Antiemetics can help prevent CINV in about 60%-70% of patients. (thebusinessresearchcompany.com)
Incidence1
  • An increase in the incidence of cancer will increase demand for antiemetics and antinauseants, thereby driving revenue for the market. (thebusinessresearchcompany.com)
Cancer1
Results1
  • this blockade results in powerful antiemetic effects. (rxlist.com)
Research2
  • The antiemetics and antinauseants market research report are one of a series of new reports from The Business Research Company that provides antiemetics and antinauseants market statistics, including antiemetics and antinauseants industry global market size, regional shares, competitors with antiemetics and antinauseants market share, detailed antiemetics and antinauseants market segments, market trends and opportunities, and any further data you may need to thrive in the antiemetics and antinauseants industry. (thebusinessresearchcompany.com)
  • This antiemetics and antinauseants market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry. (thebusinessresearchcompany.com)
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