A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment.
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
The effect of environmental or physiological factors on the driver and driving ability. Included are driving fatigue, and the effect of drugs, disease, and physical disabilities on driving.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
Any observable response or action of an adolescent.
Field of psychology concerned with the normal and abnormal behavior of adolescents. It includes mental processes as well as observable responses.
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
The medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in individuals 13-18 years.
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Individual's rights to obtain and use information collected or generated by others.
Available manpower, facilities, revenue, equipment, and supplies to produce requisite health care and services.
A component of the PUBLIC HEALTH SERVICE that provides leadership related to the delivery of health services and the requirements for and distribution of health resources, including manpower training.
Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.
A drugless system of therapy, making use of physical forces such as air, light, water, heat, massage. Treatments are often diet- and nutrition-oriented with attention given to the patient's personal history and lifestyle. (From Cassileth, Alternative Medicine Handbook, 1998, p329)
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
The act of killing oneself.
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
A serotonin uptake inhibitor that is effective in the treatment of depression.
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
A filament-like structure consisting of a shaft which projects to the surface of the SKIN from a root which is softer than the shaft and lodges in the cavity of a HAIR FOLLICLE. It is found on most surfaces of the body.
An international agreement of the World Medical Association which offers guidelines for conducting experiments using human subjects. It was adopted in 1962 and revised by the 18th World Medical Assembly at Helsinki, Finland in 1964. Subsequent revisions were made in 1975, 1983, 1989, and 1996. (From Encyclopedia of Bioethics, rev ed, 1995)
Agents of the law charged with the responsibility of maintaining and enforcing law and order among the citizenry.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.
Examination of urine by chemical, physical, or microscopic means. Routine urinalysis usually includes performing chemical screening tests, determining specific gravity, observing any unusual color or odor, screening for bacteriuria, and examining the sediment microscopically.
Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.
A country in Southeastern Asia, northwest of Australia in the Lesser Sunda Islands at the eastern end of the Indonesian archipelago. It includes the eastern half of the island of Timor, the Oecussi (Ambeno) region on the northwest portion of the island of Timor, and the islands of Pulau Atauro and Pulau Jaco. On May 20, 2002, East Timor was internationally recognized as an independent state. This followed its declared independence from Portugal on November 20, 1975 and a period of armed conflict with Indonesia.
Deliberate maltreatment of groups of humans beings including violations of generally-accepted fundamental rights as stated by the Universal Declaration of Human Rights, adopted and proclaimed by the United Nations General Assembly resolution 217 A (III) of 10 December 1948.
A strong emotional feeling of displeasure aroused by being interfered with, injured or threatened.
Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
Substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth.
A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.
Ratio of output to effort, or the ratio of effort produced to energy expended.
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)

A controlled trial of sustained-release bupropion, a nicotine patch, or both for smoking cessation. (1/684)

BACKGROUND AND METHODS: Use of nicotine-replacement therapies and the antidepressant bupropion helps people stop smoking. We conducted a double-blind, placebo-controlled comparison of sustained-release bupropion (244 subjects), a nicotine patch (244 subjects), bupropion and a nicotine patch (245 subjects), and placebo (160 subjects) for smoking cessation. Smokers with clinical depression were excluded. Treatment consisted of nine weeks of bupropion (150 mg a day for the first three days, and then 150 mg twice daily) or placebo, as well as eight weeks of nicotine-patch therapy (21 mg per day during weeks 2 through 7, 14 mg per day during week 8, and 7 mg per day during week 9) or placebo. The target day for quitting smoking was usually day 8. RESULTS: The abstinence rates at 12 months were 15.6 percent in the placebo group, as compared with 16.4 percent in the nicotine-patch group, 30.3 percent in the bupropion group (P<0.001), and 35.5 percent in the group given bupropion and the nicotine patch (P<0.001). By week 7, subjects in the placebo group had gained an average of 2.1 kg, as compared with a gain of 1.6 kg in the nicotine-patch group, a gain of 1.7 kg in the bupropion group, and a gain of 1.1 kg in the combined-treatment group (P<0.05). Weight gain at seven weeks was significantly less in the combined-treatment group than in the bupropion group and the placebo group (P<0.05 for both comparisons). A total of 311 subjects (34.8 percent) discontinued one or both medications. Seventy-nine subjects stopped treatment because of adverse events: 6 in the placebo group (3.8 percent), 16 in the nicotine-patch group (6.6 percent), 29 in the bupropion group (11.9 percent), and 28 in the combined-treatment group (11.4 percent). The most common adverse events were insomnia and headache. CONCLUSIONS: Treatment with sustained-release bupropion alone or in combination with a nicotine patch resulted in significantly higher long-term rates of smoking cessation than use of either the nicotine patch alone or placebo. Abstinence rates were higher with combination therapy than with bupropion alone, but the difference was not statistically significant.  (+info)

Modeling geriatric depression in animals: biochemical and behavioral effects of olfactory bulbectomy in young versus aged rats. (2/684)

Geriatric depression exhibits biological and therapeutic differences relative to early-onset depression. We studied olfactory bulbectomy (OBX), a paradigm that shares major features of human depression, in young versus aged rats to determine mechanisms underlying these differences. Young OBX rats showed locomotor hyperactivity and a loss of passive avoidance and tactile startle. In contrast, aged OBX animals maintained avoidance and startle responses but showed greater locomotor stimulation; the aged group also exhibited decreased grooming and suppressed feeding with novel presentation of chocolate milk, effects which were not seen in young OBX. These behavioral contrasts were accompanied by greater atrophy of the frontal/parietal cortex and midbrain in aged OBX. Serotonin transporter sites were increased in the cortex and hippocampus of young OBX rats, but were decreased in the aged OBX group. Cell signaling cascades also showed age-dependent effects, with increased adenylyl cyclase responses to monoaminergic stimulation in young OBX but no change or a decrease in aged OBX. These data indicate that there are biological distinctions in effects of OBX in young and aged animals, which, if present in geriatric depression, provide a mechanistic basis for differences in biological markers and drug responses. OBX may provide a useful animal model with which to test therapeutic interventions for geriatric depression.  (+info)

Negative immunoregulatory effects of antidepressants: inhibition of interferon-gamma and stimulation of interleukin-10 secretion. (3/684)

There is now some evidence that major depression is accompanied by activation of the inflammatory response system. There is also some evidence that antidepressants may suppress the release of cytokines, such as interleukin-1 beta (IL-1 beta) and IL-6 by activated monocytes and IL-2 and interferon-gamma (IFN gamma) by activated T cells. This study was carried out to examine the effects of clomipramine, sertraline, and trazodone on the stimulated production of IFN gamma, a pro-inflammatory cytokine, and IL-10, a negative immunoregulatory cytokine. Whole blood of nine healthy volunteers was stimulated with PHA, 5 micrograms/mL and LPS, 25 micrograms/mL for 72 hr with and without incubation with clomipramine, 10(-6) and 10(-9) M, sertraline, 10(-6) and 10(-8) M, and trazodone, 10(-6) and 10(-8) M. All three antidepressants significantly reduced IFN gamma secretion, whereas clomipramine and sertraline significantly increased IL-10 secretion in culture supernatant. All three antidepressants significantly reduced the IFN gamma/IL-10 ratio. The results suggest that antidepressants, at concentrations in the therapeutical range, have negative immunoregulatory effects through inhibition of IFN gamma and stimulation of IL-10 release.  (+info)

A cost-effective approach to the use of selective serotonin reuptake inhibitors in a Veterans Affairs Medical Center. (4/684)

In light of the tremendous expansion in the number of selective serotonin reuptake inhibitors available to the clinician, the Pharmacy and Therapeutics Committee of the Denver Veterans Affairs Medical Center considered the advantages and disadvantages of fluoxethine, paroxetine, and sertraline, to determine which agent or agents would be carried on the formulary. The committed recommended sertraline as the preferred agent for the treatment of depression, panic disorders, and obsessive-compulsive disorders. The purpose of this retrospective study was to assess the economic outcome of that decision. The study population consisted of patients at the medical center who were receiving selective serotonin reuptake inhibitors during January through March of 1994 and those were receiving these agents between September 1995 and January 1996. The expanded collection period in 1995-96 was due to a relatively new medical center policy to offer 90-day fills on medication to reduce costs. The extended collection period assured a 100% sample of patients receiving these agents. The 1994 fluoxetine to sertraline dosage equivalency ratio was 20 mg:55.6 mg, based on average daily doses of fluoxetine and sertraline of 32.7 and 90.9 mg, respectively. The cost to the medical center for an average daily dose of fluoxetine was $1.86; sertraline cost $1.22 per day. The 1996 fluoxetine to sertraline dosage equivalency ratio (20 mg:51.3 mg) had not changed significantly since 1994, indicating that the dose of 20 mg of fluoxetine remained very close to a 50-mg dose of sertraline. The average daily doses of fluoxetine and sertraline (34.9 mg and 89.7 mg, respectively) were not significantly different than the 1994 doses. Only 33 patients had been prescribed paroxetine (average daily dose, 32.4 mg). On the basis of these values, the average daily cost of fluoxetine to the medical center was $2.01, compared with $1.18 for sertraline and $1.24 for paroxetine. This $0.83 per patient per day drug acquisition cost difference between fluoxetine and sertraline results in a drug cost reduction of $302,674 per year.  (+info)

Effectiveness and economic impact of antidepressant medications: a review. (5/684)

This article reviews the existing literature on the pharmacoeconomics and effectiveness of antidepressant medications. Although selective serotonin reuptake inhibitors (SSRIs) have not proved to be more efficacious than the older tricyclics, and their prescription costs are significantly higher, they provide superior effectiveness; ie, patients are less likely to discontinue taking them or switch antidepressants. Pharmacoeconomic studies consistently demonstrate a relationship between this superior effectiveness and reductions in overall treatment costs, often through decreased utilization of medical and hospital services. The most conservative study found a cost offset that more than negated the extra cost of drugs, although the cost savings were not statistically significant. Other studies found statistically significant lowering of utilization costs by using SSRIs rather than tricyclics. Studies comparing SSRIs with each other present conflicting findings, although fluoxetine appears to have an edge over sertraline and paroxetine with regards to effectiveness and pharmacoeconomics. More studies employing a prospective outcome design and naturalistic study setting need to be conducted with SSRIs and other new antidepressants.  (+info)

Course of antidepressant treatment with tricyclic versus selective serotonin reuptake inhibitor agents: a comparison in managed care and fee-for-service environments. (6/684)

We compared course of treatment with tricyclic antidepressant drugs (TCADs) and selective serotonin reuptake inhibitors (SSRIs) to assess interactive effects of antidepressant type with payer type and patient characteristics. A nationwide sampling of adults (n = 4,252) from approximately equal numbers of health maintenance organization (HMO) and indemnity enrollees were prescribed no antidepressants for 9 months, and thereafter prescribed a TCAD or SSRI. Using a retrospective analysis of prescription claims, these cohorts of TCAD and SSRI utilizers were followed for 13 to 16 months after their initial antidepressant prescription. Outcome measures included (1) termination of antidepressant treatment before 1 month; and (2) failure to receive at least one therapeutic dose during treatment lasting 3 months or more. Rates of premature termination and subtherapeutic dosing were significantly higher for TCAD-treated than SSRI-treated patients, and for HMO than indemnity enrollees. The interaction of HMO enrollment and TCAD use was associated with particularly high rates. Excluding patients terminating in the first month, the proportions of TCAD and SSRI utilizers remaining in treatment over time were not significantly different. We conclude that SSRIs may provide advantages in treatment adherence and therapeutic dosing, particularly in environments with limited prescriber time. The first month of treatment may be especially critical in determining compliance.  (+info)

Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people. (7/684)

AIMS: To establish the incidence, time course and risk factors of hyponatraemia complicating treatment with fluoxetine or paroxetine in an elderly population. METHODS: Retrospective descriptive and case control study in an inpatient/outpatient assessment and rehabilitation service for people aged 65 years and over. Fourteen elderly patients with hyponatraemia complicating treatment with fluoxetine or paroxetine, matched with 56 controls drawn from 845 patients treated with fluoxetine or paroxetine over 3.5 years. No other SSRI antidepressants were used over the study period. RESULTS: The incidence of hyponatraemia was 4.7/1000 people treated/year (6.3/1000 for fluoxetine and 3.5/1000 for paroxetine). Hyponatraemia was detected at a median 13.5 (mean 18.6, range 4-64) days after commencing the drug. Mean (95% confidence intervals) body weights were lower in cases at 53.0 (95% CI 46.5-59.5) kg compared with controls at 64.5 (95% CI 60.1-68.4) kg (P<0.01). 71% of cases were women compared with 45% of controls (P=0.07) but the effect of gender was confounded by body weight. There were trends for cases to be older (odds ratio 1.10: 95% CI 0.99, 1.23) and lighter (odds ratio 0.92, 95% CI 0.86, 0.99). CONCLUSIONS: Approximately 1 in 200 elderly people treated per year with fluoxetine or paroxetine developed complicating hyponatraemia. Low body weight was a particular risk factor. Most cases occurred within 3 weeks of treatment.  (+info)

Effects of fluoxetine on the polysomnogram in outpatients with major depression. (8/684)

This study investigated the effects of open-label fluoxetine (20 mg/d) on the polysomnogram (PSG) in depressed outpatients (n = 58) who were treated for 5 weeks, after which dose escalation was available (< or = 40 mg/d), based on clinical judgment. Thirty-six patients completed all 10 weeks of acute phase treatment and responded (HRS-D < or = 10). PSG assessments were conducted and subjective sleep evaluations were gathered at baseline and at weeks 1, 5, and 10. Of the 36 subjects who completed the acute phase, 17 were reevaluated after 30 weeks on continuation phase treatment and 13 after approximately 7 weeks (range 6-8 weeks) following medication discontinuation. Acute phase treatment in responders was associated with significant increases in REM latency, Stage 1 sleep, and REM density, as well as significant decreases in sleep efficiency, total REM sleep, and Stage 2 sleep. Conversely, subjective measures of sleep indicated a steady improvement during acute phase treatment. After fluoxetine was discontinued, total REM sleep and sleep efficiency were found to be increased as compared to baseline.  (+info)

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1. CIMETIDINE - Concurrent administration of venlafaxine and cimetidine (both at steady state) has resulted in a 43% reduction in the oral clearance of venlafaxine and a 60% increase in the AUC and peak concentration of venlafaxine (Prod Info Effexor(R), 2000). The major metabolite, O-desmethylvenlafaxine, was unaffected by cimetidine, and is present in much greater amounts than the parent drug. It is not known if a clinically significant interaction will occur with this combination. Patients should be monitored for signs of venlafaxine toxicity, and the dose of venlafaxine reduced if necessary ...
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Its been just over twenty-five years since Prozac came to market, and more than twenty per cent of Americans now regularly take mind-altering drugs prescribed by their doctors. Almost as familiar as brands like Zoloft and Lexapro is the worry about what it means that the daily routine in many households. A friend gave me Sylvia Plaths The Bell Jar at a sleepover for my fourteenth birthday. After the other girls fell asleep, I stayed up and read the entire novel. A likely choice for a moody teen-ager already contemplating the inexorable passing of her youth. So when I heard that a study published this month.. ByEli Annas Zyprexa was new yorker prozac more revenue than Prozac. It isomers the companys new yorker prozac troche. But the data presented at the Sound meeting made it late that something strange was going: the therapeutic power of the effects appeared to be steadily gone. A recent study investigated. The choice is a prospective one: to be explored during pregnancy, with troubling ...
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Canada - In consultation with Health Canada, the manufacturer of nefazodone (Serzone-5HT2®) has decided to discontinue sales of the product from the market in Canada effective 27 November 2003. Nefazodone has been associated with adverse hepatic events including liver failure requiring transplantation.. Nefazodone is indicated for the symptomatic relief of depressive illness. Since introduction in 1994, nefazodone has been temporally associated with hepatic adverse events such as jaundice, hepatitis and hepatocellular necrosis in patients receiving therapeutic doses. As of December 2002, there were 51 Canadian reports of hepatotoxicity, ranging from no symptoms to transplantation, suspected to be associated with nefazodone use. One of two transplant recipients subsequently died. Cases of liver injury have occurred as early as a few weeks after initiation of therapy or after continuous use for up to 3 years. To date, no risk factor to predict patients who will develop irreversible liver failure ...
Bupropion is an atypical antidepressant that also has usefulness as a smoking-cessation aid. Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute to its antidepressant activity, this metabolite may also contribute to the smoking-cessation properties of bupropion. This study investigated the effects of hydrobupropion enantiomers on monoamine
The antidepressant fluoxetine, the active ingredient in Eli Lillys off-patent Prozac, may help to curb disease activity in the relapsing remitting form of multiple sclerosis, according to preliminary research from a new study. - News - PharmaTimes
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No studies conducted so far have directly shown superiority of vilazodone over other antidepressants. However, its potential advantage over other antidepressants could be speculated from its distinctive mechanism of action and clinical and pre-clinical studies. Vilazodones partial agonist actions in both presynaptic and postsynaptic 5-HT1A receptors may overcome the chronological lag observed in other antidepressants.23,30 This putative benefit was demonstrated in a recent electrophysiological animal study.38 In line with preclinical findings, the two pivotal trials, a pooled analysis, and a post-hoc study also showed that significant improvements in depressive symptoms were noted within 1 week after vilazodone administration. 13,14,40 However, more rapid onset of vilazodone should be interpreted with caution because the study did not have an active comparator. Moreover, such rapid effect of vilazodone was not replicated in the subsequent trial, and the effect size was also not large enough to ...
Improvement of the sleep-wake cycle as a target for remission in depression. Back to. 24 the interaction of two processes is. the latter is food,.Nous navons aucune idée de ce qui interaction des. fluoxetine HCl) Sarafem (fluoxetine HCl. antidépresseurs envoyés au Food and Drug.En janvier 2009, un comité de spécialistes réunis par la Food and Drug Administration. prozac, fluoxétine. les danger de la toxicomanie au prozac. deroxat,.interaction test. These effects were. Fluoxetine and SSR240600 were devoid of effects in this test. In the tonic immobility test in gerbils,. food and water.Interactions For Glimepiride Based on experience with glimepiride and on what is known of other sulfonylureas,. fluoxetine; guanethidine; ifosfamide;.Prozac est le nom de marque de la fluoxétine,. qui a été approuvé par la Food and Drug Administration. Interactions au Prozac (fluoxétine ...
The aim of the present study was to test the hypothesis that the application of fluoxetine - a highly selective serotonin reuptake inhibitor (SSRI) - in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels. Testis were removed, weighed, and processed for morphometric analysis. Fluoxetine groups presented decreased body and testicular weight when compared with the control group on the 21st day. Our findings show that the manipulation of the ...
The evidence suggests that developmental toxicity can also occur in the form of shortened gestational duration and reduced birth weight at term.. The experts also noted several reports that found fluoxetine could affect a patients ability to achieve sexual climax -- both male and female.. It can get into breast milk and is found in the blood of newborns of mothers taking the drug.. The report, available on the Internet at http://cerhr.niehs.nih.gov/news/fluoxetine/fluoxetine_final.pdf,says fluoxetine is widely used and can now be found in the environment.. Fluoxetine has been reported in U.S. surface waters, presumably derived from urine and feces of people on therapy, the report reads. One researcher found fluoxetine in bluegill fish.. The presence of fluoxetine ... in wastewater/groundwater/sediment should be investigated, the report recommends ...
Introduction Prozac (fluoxetine hydrochloride) is a psychotropic drug for oral administration. Prozac is used to treat depression, panic disorder,...
Bupropion is indicated to promote smoking cessation. Animal studies suggest that the pharmacologic activity of bupropion can be mediated by its major metabolite, hydroxybupropion. We measured plasma bupropion and its metabolite levels in a double-blind, placebo controlled, randomized smoking-cessati …
Buy Fluoxetine Online! Fluoxetine is an antidepressant. As a result, it is not recommended to stop taking the drug suddenly. Also known by its generic name, Fluoxetine, Fluoxetine is a selective serotonin reuptake inhibitor (SSRI).
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Prozac (fluoxetine) has a: long half-life and doesnt work its way into the nervous system at the proper depth to begin to alter mood for about 14 to 21 days, in most cases. Some folks think a month is not too long to wait. (This is not the same as the initial rush some patients experience as the drug first is introduced...) Quitting Prozac (fluoxetine) takes about the same time to leave the body, so give it 2+weeks to be safe. ...Read more ...
Fluoxetine (brand name Prozac) belongs to the SSRI class of inhibitors; selective serotonin reuptake inhibitors. It does not inhibit the reuptake of norepinephrine and dopamine when used at a therapeutic dose (40mg-80mg), but can delay the reuptake of serotonin, which then results in serotonin remaining in the system for longer after it is released. Fluoxetine works…
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http://www.yourlawyer.com/topics/overview/paxil_birth_defects>Paxil and Prozac, two popular antidepressants, have been linked to heart birth defects by a new study.  According to an article published in the November issue of The British Journal of Clinical Pharmacology, the risk for such birth defects was the highest among Prozac users who also smoked during their pregnancy.. For the study, researchers from Israel, Italy and Germany looked at the pregnancy outcomes of 2,191 women. Of those, 410 had taken Paxil during their pregnancy, while 314 had taken Prozac. The remaining 1,467 had no exposure to either antidepressant.. Among the group taking Prozac, the prevalence of major heart birth defects was 2.8%. It was 2% in the Paxil group and 0.6% in the control group. That means that women who took Prozac during pregnancy were 4.47 times more likely to have a baby with a heart anomaly and women who took Paxil were 2.66 times more ...
"Sertraline versus other antidepressive agents for depression". The Cochrane Database of Systematic Reviews (4): CD006117. doi: ... Hansen RA, Gaynes BN, Gartlehner G, Moore CG, Tiwari R, Lohr KN (May 2008). "Efficacy and tolerability of second-generation ... For example, a meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms ... Cusack B, Nelson A, Richelson E (May 1994). "Binding of antidepressants to human brain receptors: focus on newer generation ...
Second-Generation+Antidepressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) Diagrams at ... The term "third generation antidepressant" is sometimes used to refer to newer antidepressants, from the 1990s and 2000s, often ... The second-generation antidepressants are a class of antidepressants characterized primarily by the era of their introduction, ... This list is not exhaustive, and different sources vary upon which items should be considered second-generation. Amineptine ...
"Milnacipran versus other antidepressive agents for depression". The Cochrane Database of Systematic Reviews. 8 (3): CD006529. ... a potential fourth generation antidepressant drug". Neuropharmacology. 24 (12): 1211-9. doi:10.1016/0028-3908(85)90157-1. PMID ... acceptability and tolerability when comparing milnacipran with other antidepressant agents. However, compared with TCAs, ...
"Paroxetine versus other anti-depressive agents for depression". The Cochrane Database of Systematic Reviews (4): CD006531. doi: ... Antihistamines (first-generation) (e.g., brompheniramine, buclizine, captodiame, chlorphenamine (chlorpheniramine), cinnarizine ... See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine ... Owens JM, Knight DL, Nemeroff CB (2002-08-01). "[Second generation SSRIS: human monoamine transporter binding profile of ...
"Paroxetine versus other anti-depressive agents for depression". The Cochrane Database of Systematic Reviews (4): CD006531. doi: ... Owens, J. M.; Knight, D. L.; Nemeroff, C. B. (2002-08-01). "[Second generation SSRIS: human monoamine transporter binding ... Owens, MJ; Knight, DL; Nemeroff, CB (1 September 2001). "Second-generation SSRIs: human monoamine transporter binding profile ... 28 February 2009). "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta- ...
... first-generation and newer agents. Ergoline derived agonists are the first generation and are not used as much as the newer ... further research is crucial to establish the anti-depressive effects of dopamine agonists in treating depressive symptoms and ... Ergoline-derived agents, bromocriptine and cabergoline are mostly used in treatment. Research shows that these agents reduce ... dopamine reuptake inhibitors and dopamine releasing agents. The most commonly prescribed indirect agonists of dopamine ...
Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... Cesura AM, Pletscher A (1992). The new generation of monoamine oxidase inhibitors. Prog Drug Res. 38. pp. 171-297. doi:10.1007/ ... De Vanna, M; Kummer, J; Agnoli, A; Gentili, P; Lorizio, A; Anand, R (1990). "Moclobemide compared with second-generation ... Gram LF (September 1994). "[Antidepressive drug therapy, suicidal ideation and suicide, 2 cases reported in connection with ...
... antidepressive agents MeSH D27.505.954.427.700.122.050 - antidepressive agents, second-generation MeSH D27.505.954.427.700.122. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Tricyclic+Antidepressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH). ... Cusack B, Nelson A, Richelson E (1994). "Binding of antidepressants to human brain receptors: focus on newer generation ... having been replaced by more effective agents with fewer side effects such as atomoxetine (Strattera, Tomoxetin) and stimulants ...
Risk of overdose is increased in patients taking multiple serotonergic agents or interacting agents. Symptoms of SNRI overdose ... Over the past two decades, second-generation antidepressants have simply replaced first-generation antidepressants, such as ... Venlafaxine was the first compound described in a new class of antidepressive substances called phenylethylamines. These ... Agents with dual serotonin and norepinephrine reuptake inhibition (SNRIs) are sometimes called non-tricyclic serotonin and ...
These include lithium and thyroid augmentation, dopamine agonists, sex steroids, NRIs, glucocorticoid-specific agents, or the ... It is unknown if undergoing psychological therapy at the same time as taking anti-depressants enhances the anti-depressive ... "Efficacy and tolerability of second-generation antidepressants in social anxiety disorder". International Clinical ... From a 2500-year-old apotropic comes a current antidepressive. The cultural history and mistique of St. John's wort]. Pharmazie ...
Over the past two decades, second-generation antidepressants have gradually replaced first-generation antidepressants, such as ... Selectivity of antidepressant agents are based on the neurotransmitters that are thought to influence symptoms of depression.[ ... Venlafaxine was the first compound described in a new class of antidepressive substances called phenylethylamines. These ... Agents with dual serotonin and norepinephrine reuptake inhibition (SNRIs) are sometimes called non-tricyclic serotonin and ...
The drug is described as an atypical or "second-generation" TCA because, unlike other TCAs, it seems to be a fairly weak ... ISBN 978-0-915274-23-9. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties ... Berger M, Gastpar M (1996). "Trimipramine: a challenge to current concepts on antidepressives". Eur Arch Psychiatry Clin ... Cusack B, Nelson A, Richelson E (1994). "Binding of antidepressants to human brain receptors: focus on newer generation ...
These include psychedelic agents, such as lysergic acid diethylamide (LSD) Dolder PC, Schmid Y, Haschke M, Rentsch KM, Liechti ... Dos Santos RG, Osório FL, Crippa JA, Riba J, Zuardi AW, Hallak JE (June 2016). "Antidepressive, anxiolytic, and antiaddictive ... Veysey they profoundly influenced the thinking of the new generation of youth. On October 24, 1968, possession of LSD was made ... "Evaluating LSD as a psychotherapeutic agent". In Hoffer A (ed.). A program for the treatment of alcoholism: LSD, malvaria, and ...
Brené S, Bjørnebekk A, Aberg E, Mathé AA, Olson L, Werme M (2007). "Running is rewarding and antidepressive". Physiol. Behav. ... The clinical actions of fluoxetine, like those of many neuropharmacologic agents, reflect drug-induced neural plasticity, which ... the generation of new neurons postnatally). Malenka RC, Nestler EJ, Hyman SE (2009). "Chapter 8:Atypical Neurotransmitters". In ...
"Citalopram versus other anti-depressive agents for depression". The Cochrane Database of Systematic Reviews (7): CD006534. doi: ... Tiagabine Second-generation antipsychotics (SGAs) Olanzapine (evidence of effectiveness is merely a trend) Ziprasidone ... Like other serotonergic agents, SNRIs have the potential to cause serotonin syndrome, a potentially fatal systemic response to ... Overdose of an SSRI or concomitant use with another agent that causes increased levels of serotonin can result in serotonin ...
Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. ... From a 2500-year-old apotropic comes a current antidepressive. The cultural history and mistique of St. John's wort]։ Pharmazie ... Efficacy and Tolerability of Second-Generation Antidepressants in Social Anxiety Disorder»։ International Clinical ... of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for ...
Over the past two decades, second-generation antidepressants have simply replaced first-generation antidepressants, such as ... Risk of overdose is increased in patients taking multiple serotonergic agents or interacting agents. ... Venlafaxine was the first compound described in a new class of antidepressive substances called phenylethylamines. These ... Agents with dual serotonin and norepinephrine reuptake inhibition (SNRIs) are sometimes called non-tricyclic serotonin and ...
Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. Physiological Effects of Drugs. Antidepressive Agents ... Because the effectiveness of these agents has been based largely on improvement in subjective reporting of hot flashes, it is ...
Antidepressive Agents, Second-Generation. Antidepressive Agents. Psychotropic Drugs. Dopamine Uptake Inhibitors. ... Dopamine Agents. Neurotransmitter Agents. Physiological Effects of Drugs. Cytochrome P-450 CYP2D6 Inhibitors. Cytochrome P-450 ...
Serotonin Agents. Physiological Effects of Drugs. Antidepressive Agents, Second-Generation. Antidepressive Agents. Psychotropic ...
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Toxic manifestations of amoxapine overdosage differ significantly from those of other tricyclic antidepressants. Serious cardiovascular effects are seldom if ever observed. However, CNS effects, particularly grand mal convulsions, occur frequently, and treatment should be directed primarily toward prevention or control of seizures. Status epilepticus may develop and constitutes a neurologic emergency. Coma and acidosis are other serious complications of substantial amoxapine overdosage in some cases. Renal failure may develop two to five days after toxic overdose in patients who may appear otherwise recovered. Acute tubular necrosis with rhabdomuolysis and myolobinurla is the most common renal complication in such cases. This reaction probably occurs in less than 5% of overdose cases, and typically in those who have experienced multiple seizures ...
Antidepressive Agents, Second-Generation / metabolism* * Antidepressive Agents, Second-Generation / therapeutic use* * Aryl ...
Antidepressive Agents, Second-Generation Administrative Information. LactMed Record Number. 404 Last Revision Date. 20171010 ...
Antidepressive Agents, Second-Generation / therapeutic use* * Child * Depression / drug therapy* * Depression / psychology* ...
Pharmacological Actions : Antidepressive Agents: Second-Generation. [+] Resveratrol may prevent atherosclerosis in diabetic ... Pharmacological Actions : Cardioprotective, Hypoglycemic Agents, Vasodilator Agents. Additional Keywords : Drug Synergy, ... Pharmacological Actions : Hypoglycemic Agents, Interleukin-6 Downregulation, Interleukin-8 downregulation, Tumor Necrosis ... Pine bark extract reduces thromboxane generation in diabetic rats.Mar 01, 2008. ...
Pharmacological Actions : Antidepressive Agents: Second-Generation. [+] Soy sauce has antioxidant and anti-glycation properties ... Pharmacological Actions : Hypoglycemic Agents, Insulin Sensitizers. Additional Keywords : Beta Cell Protection, Beta Cell ...
Antidepressive Agent, Second-Generation; Amino Acid, Essential Toxin, Toxin-Target Database T3D4369. ... Incompatible with strong acids, strong oxidizing agents. OU Chemical Safety Data (No longer updated) More details. ...
suicide; antidepressive agents; second-generation; paroxetine; toxicology; pharmacoepidemiology National Category Medical and ...
0 (Antidepressive Agents, Second-Generation); 0 (Antipsychotic Agents); 0 (Fat Emulsions, Intravenous); 0DHU5B8D6V (Citalopram ... 0 (Anti-Anxiety Agents); 0 (Antidepressive Agents); 0 (Antiemetics); 12794-10-4 (Benzodiazepines); 250PJI13LM (Mianserin); ... 0 (Anti-Anxiety Agents); 0 (Fibrinolytic Agents); EC 3.4.21.68 (Tissue Plasminogen Activator); X015L14V0O (Bromazepam). ... 0 (Antipsychotic Agents); 0 (Cyclopropanes); 0 (Fixatives); 0 (Narcotics); 1HG84L3525 (Formaldehyde); 44RAL3456C ( ...
Antidepressive Agents, Second-Generation. *Fluoxetine. Topics. *Adult. *Antidepressive Agents, Second-Generation (therapeutic ...
Sertraline versus other antidepressive agents for depression Cochrane Systematic Reviews, 14-Mar-2010 The National Institute ... The question as to whether and, if so, how much the effects of the various second generation ... In many countries of the industrialised world second generation (atypical) antipsychotics have become the first line drug ...
antidepressive agents, clinical trials, depression, locus of control, personality assessment, second-generation ...
Antidepressive Agents, Second-Generation/*therapeutic use. Citalopram/*therapeutic use. Depression/*drug therapy ...
"Sertraline versus other antidepressive agents for depression". The Cochrane Database of Systematic Reviews (4): CD006117. doi: ... Hansen RA, Gaynes BN, Gartlehner G, Moore CG, Tiwari R, Lohr KN (May 2008). "Efficacy and tolerability of second-generation ... For example, a meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms ... Cusack B, Nelson A, Richelson E (May 1994). "Binding of antidepressants to human brain receptors: focus on newer generation ...
Antidepressive Agents. Phase 2. 32. Antidepressive Agents, Second-Generation. Phase 2. 33. Cytochrome P-450 CYP2D6 Inhibitors. ...
Neurotransmitter Agents. Phase 4,Phase 1,Phase 2,Not Applicable. 13. Antidepressive Agents, Second-Generation. Phase 4. ... Anti-Infective Agents, Local. Not Applicable. Interventional clinical trials:. (show all 38) #. Name. Status. NCT ID. Phase. ...
... we began with a focused PubMed search on second-generation antidepressive agents and depressive disorder using MeSH terms. ... We ran a supplemental query in PubMed on March 3, 2010 specific to immediate release and extended release antidepressive agents ... If a patient has responded to one agent in the past, is that agent better than current pharmacologic alternatives at treating ... In general, the figure illustrates how second generation antidepressants versus other second generation antidepressants may ...
Antidepressive Agents, Second-Generation/adverse effects*. *Cardiomyopathies/chemically induced*/diagnosis. *Cyclohexanols/ ... The patient was concomitantly taking Centella asiatica and Fucus vesiculosus as phytotherapeutic agents. Chest CT angiography ... The patient was concomitantly taking Centella asiatica and Fucus vesiculosus as phytotherapeutic agents. Chest CT angiography ...
Second-Generation+Antidepressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) Diagrams at ... The term "third generation antidepressant" is sometimes used to refer to newer antidepressants, from the 1990s and 2000s, often ... The second-generation antidepressants are a class of antidepressants characterized primarily by the era of their introduction, ... This list is not exhaustive, and different sources vary upon which items should be considered second-generation. Amineptine ...
Antidepressive Agents, Second-Generation. *. Central Nervous System Agents. *. Cytochrome P-450 CYP2D6 Inhibitors ...
Second-Generation 7D7RX5A8MO Venlafaxine Hydrochloride IM Acute Disease Antidepressive Agents, Second-Generation adverse ... eng Letter China Chin Med J (Engl) 7513795 0366-6999 0 Antidepressive Agents, ...
Drugs and Important Biological Agents (IBA) related to Major Depressive Disorder: 1. Antidepressive Agents (Antidepressants)IBA ... 12/01/2009 - "Treatment with the newer generation antidepressants is considered generally effective for most patients with ... 12/01/2005 - "Although serotonin reuptake inhibitors are recommended as first-line agents for major depressive disorder, ... but long-term data are needed to establish whether this agent confers persistent benefits. ". 06/01/1996 - "The results from ...
"Antidepressive Agents" OR "Antidepressive Agents, Second Generation" OR "Antidepressive Agents, Tricyclic" OR "Serotonin Agents ... inhibitors/or exp serotonin agents/or exp serotonin receptor agonists/or exp antidepressive agents/or exp antidepressive agents ... Antidepressive agents or monoamine oxidase inhibitors or serotonin uptake inhibitors or norepinephrine uptake inhibitors and ... A multimodal analgesic approach is commonly used3,4 ; however, currently using agents such as opioids,5 local anesthetics,6 ...
... and antidepressive agents second generation.RESULTS: With its dual action of serotonin and noradrenergic reuptake inhibition, ...
... "antidepressive agents", "second generation" (Pharmacological Action) AND "randomized controlled trial" (Publication Type) AND " ... antidepressive agent, permission to additionally receive psychotherapeutic treatment), and outcome data (primary and secondary ... Comparative efficacy and tolerability of first-generation and newer-generation antidepressant medications for depressive ... 1 allocation generation, 2 allocation concealment, 3 blinding of participant, personnel and outcome assessors, 4 incomplete ...
  • Citalopram versus other anti-depressive agents for depression. (nih.gov)
  • Citalopram hydrobromide belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). (t3db.ca)
  • This is due to the exploration of novel therapeutic agents for suppression or relief of pain as well as depression ( Anil, 2010 ). (frontiersin.org)
  • Therapeutic agents available for the treatment of anxiety include benzodiazepines, opioids, and non-steroidal anti-inflammatory drugs. (frontiersin.org)
  • Search terms included venlafaxine extended-release, venlafaxine XR, treatment-resistant depression, depressive disorders, anxiety disorders, generalized anxiety disorder, and antidepressive agents second generation.RESULTS: With its dual action of serotonin and noradrenergic reuptake inhibition, venlafaxine has been shown to be superior in efficacy to selective serotonin reuptake inhibitors for severe major depressive disorder, treatment-resistant depression, and depressive symptom remission. (biopsychiatry.com)
  • Escitalopram versus other antidepressive agents for depression. (nih.gov)
  • Randomised controlled trials allocating adult participants with major depression to agomelatine versus any other antidepressive agent. (unboundmedicine.com)
  • We therefore did a multiple-treatments meta-analysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 new-generation antidepressants on major depression. (ox.ac.uk)
  • Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis. (ox.ac.uk)
  • Here, we present a protocol for a systematic review and network meta-analysis aimed at updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. (ox.ac.uk)
  • Pharmacotherapy dominates the medical management of depressive disorders and may include first-generation antidepressants (tricyclic antidepressants and monoamine oxidase inhibitors) and more recently developed second-generation antidepressants. (ahrq.gov)
  • Although fluoxetine should be added to formularies, its use should be reserved for treatment of those who do not respond to or do not tolerate tricyclic agents. (uthscsa.edu)
  • However, first-generation antidepressants often produce multiple side effects that many patients find intolerable, and the risk for harm when taken in overdose or in combination with certain medications is high. (ahrq.gov)
  • Because of their relatively favorable side effect profile, the second-generation antidepressants play a prominent role in the management of patients with major depressive disorder and are the focus of this review. (ahrq.gov)
  • For adults with major depressive disorder (MDD), dysthymia, or subsyndromal depressive disorders, do second-generation antidepressants differ in efficacy or effectiveness in treating depressive symptoms? (ahrq.gov)
  • Are there any differences in efficacy or effectiveness between immediate release and extended release formulations of second-generation antidepressants? (ahrq.gov)
  • For adults with a depressive syndrome that has not responded to acute antidepressant treatment or has relapsed during continuation phase treatment, do alternative second-generation antidepressants differ in their efficacy or effectiveness? (ahrq.gov)
  • Children and adolescents with major depressive disorder (MDD) appear to be more responsive to placebo than adults in randomized placebo-controlled trials (RCTs) of second and newer generation antidepressants (SNG-AD). (springer.com)
  • Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. (nih.gov)
  • Network Meta-Analysis and Cost-Effectiveness Analysis of New Generation Antidepressants. (nih.gov)
  • BACKGROUND: Conventional meta-analyses have shown inconsistent results for efficacy of second-generation antidepressants. (ox.ac.uk)
  • BACKGROUND: Recent US and UK clinical practice guidelines recommend that second-generation antidepressants should be considered amongst the best first-line options when drug therapy is indicated for a depressive episode. (ox.ac.uk)
  • Systematic reviews have already highlighted some differences in efficacy between second-generation antidepressants. (ox.ac.uk)
  • The antidepressant agents were significantly more efficacious than the placebos, and venlafaxine was more efficacious than fluoxetine. (biomedcentral.com)
  • These second-generation treatments include selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). (ahrq.gov)
  • A serotonin uptake inhibitor that is used as an antidepressive agent. (t3db.ca)
  • This study examined the effect of bupropion XL, an extended release formulation of the nonserotonergic antidepressant agent bupropion, using a paradigm that investigated both negative emotional response and attentional processing. (duke.edu)
  • Adrenergic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • This agent was significantly superior to buspirone on the HAD anxiety subscale. (duke.edu)
  • In general, the efficacy of first- and second-generation antidepressant medications is similar (Mulrow et al 1999). (ahrq.gov)
  • Psychotropic-related hip fractures: meta-analysis of first-generation and second-generation antidepressant and antipsychotic drugs. (naver.com)
  • As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. (t3db.ca)
  • Second-generation antipsychotics in major depressive disorder: update and clinical perspective. (semanticscholar.org)
  • The antidepressant drugs and ECS did not alter VGLUT1 mRNA abundance after acute administration, and no change was detected after repeated treatment with the antipsychotic agents, haloperidol and chlorpromazine. (ox.ac.uk)
  • This graph shows the total number of publications written about "Adrenergic Agents" by people in Harvard Catalyst Profiles by year, and whether "Adrenergic Agents" was a major or minor topic of these publication. (harvard.edu)
  • PURPOSE OF REVIEW The aim of this systematic review was to examine the efficacy and safety of second-generation antipsychotics (SGAs) in nonpsychotic major depressive disorder (MDD). (semanticscholar.org)
  • CONCLUSION: Venlafaxine XR is an effective, safe, and well-tolerated once-daily anxiolytic agent in patients with GAD without comorbid major depressive disorder. (duke.edu)
  • Ergoline derived agonists are the first generation and are not used as much as the newer generation the non-ergoline derived agonists. (wikipedia.org)
  • Adaptogenic drugs are those which are useful as anti-stress agents by promoting non-specific resistance of the body. (isharonline.org)
  • Pharmacological and fluid agents, when used as an adjunct during pelvic surgery for the prevention of adhesions, may not improve pregnancy outcomes or pain. (essentialevidenceplus.com)
  • Because the effectiveness of these agents has been based largely on improvement in subjective reporting of hot flashes, it is not clear whether benefits are due to physiological effects on hot flashes or due to improvements in mood or other related symptoms. (clinicaltrials.gov)
  • Ergoline-derived agents, bromocriptine and cabergoline are mostly used in treatment. (wikipedia.org)
  • most of these agents are merely bacteriostatic, induce resistance in the organisms, and may be toxic. (healthmatics.info)
  • Gaspari R. Reply to: In a subset of PEA patients, do continuous infusions of adrenergic agents improve chances of ROSC? (harvard.edu)
  • Wong ML. In a subset of PEA patients, do continuous infusions of adrenergic agents improve chances of ROSC? (harvard.edu)
  • Polypodium leucotomos extract is a commonly used systemic photoprotective agent. (nel.edu)
  • Risk of bias was assessed for the generation of the allocation sequence, allocation concealment, masking, incomplete outcome data, and sponsorship bias. (ox.ac.uk)
  • In some Chinese studies, the generation of the randomization sequence raised concern about their experimental nature, and in almost all included studies, the concealment of allocation was not properly described. (ox.ac.uk)