Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.
Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.
A tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.
The first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
The observable response an animal makes to any situation.
A furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from tardive dyskinesia in preference to tricyclic antidepressants, which aggravate this condition.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.
Spontaneous verbalization of whatever comes to mind.
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
The return of a sign, symptom, or disease after a remission.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
The effect of environmental or physiological factors on the driver and driving ability. Included are driving fatigue, and the effect of drugs, disease, and physical disabilities on driving.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
Accidents on streets, roads, and highways involving drivers, passengers, pedestrians, or vehicles. Traffic accidents refer to AUTOMOBILES (passenger cars, buses, and trucks), BICYCLING, and MOTORCYCLES but not OFF-ROAD MOTOR VEHICLES; RAILROADS nor snowmobiles.
Female parents, human or animal.
An infant during the first month after birth.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A plant genus, in the IRIDACEAE family, known as a source of Saffron.
A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.
A creeping annual plant species of the CUCURBITACEAE family. It has a rough succulent, trailing stem and hairy leaves with three to five pointed lobes.
A plant genus of the family BRASSICACEAE known for its peppery red root.
Aromatic substances added to food before or after cooking to enhance its flavor. These are usually of vegetable origin.
A syndrome in the elderly characterized by proximal joint and muscle pain, high erythrocyte sedimentation rate, and a self-limiting course. Pain is usually accompanied by evidence of an inflammatory reaction. Women are affected twice as commonly as men and Caucasians more frequently than other groups. The condition is frequently associated with GIANT CELL ARTERITIS and some theories pose the possibility that the two diseases arise from a single etiology or even that they are the same entity.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (1/3228)

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities.  (+info)

Psychotropic drug use among women. (2/3228)

The consistent 2:1 ratio of women to men in the receipt of prescriptions for psychotropic drugs is reflected in the higher rates for women of neurotic illness, symptoms of both physical and mental discomfort, and help-seeking and drug-taking behaviour. Physicians' perceptions of the problems presented by their male and female patients influence their prescribing of these drugs. Recent statistics in Ontario indicate that greater use of physicians' services by women is an inadequate explanation of the higher rate of prescribing of psychotropic drugs to women. A longitudinal study of a large insured population in Ontario showed that almost twice the proportion of females, compared with males, received a prescription for psychotropic drugs in 1970-71 and in 1973-74, a higher proportion of females received multiple prescriptions for each drug class, and males were more likely than females to have received only one prescription in a year.  (+info)

Alternative insurance arrangements and the treatment of depression: what are the facts? (3/3228)

Using insurance claims data from nine large self-insured employers offering 26 alternative health benefit plans, we examine empirically how the composition and utilization for the treatment of depression vary under alternative organizational forms of insurance (indemnity, preferred provider organization networks, and mental health carve-outs), and variations in patient cost-sharing (copayments for psychotherapy and for prescription drugs). Although total outpatient mental health and substance abuse expenditures per treated individual do not vary significantly across insurance forms, the depressed outpatient is more likely to receive anti-depressant drug medications is preferred provider organizations and carve-outs than when covered by indemnity insurance. Those individuals facing higher copayments for psychotherapy are more likely to receive anti-depressant drug medications. For those receiving treatment, increases in prescription drug copayments tend to increase the share of anti-depressant drug medication costs accounted for by the newest (and more costly) generation of drugs, the selective serotonin reuptake inhibitors.  (+info)

Outpatient antidepressant utilization in a Dutch sick fund. (4/3228)

OBJECTIVE: To identify quality improvement opportunities in the management of depression by evaluating patterns of antidepressant use and concurrent use of anxiolytics or sedative/hypnotics among patients who initiated therapy with amitriptyline, fluoxetine, fluvoxamine, or paroxetine. DESIGN: A longitudinal, retrospective study using electronic prescription data from a Dutch sick fund, ZAO Zorgverzekeringen. PATIENTS AND METHODS: The study patients (n = 2,554) initiated therapy between October 1, 1994 and December 31, 1995. Follow-up periods were 6 months (antidepressant use) and 60 days (concurrent anxiolytic and sedative/hypnotic use). RESULTS: The three key findings were as follows: (1) the majority of patients received less than 4 months of therapy (more common for patients receiving amitriptyline); (2) the average daily doses for initial prescriptions for all four study drugs were below the recommended therapeutic minimums for depression (overall and final amitriptyline doses also were consistently low); and (3) the incidence of concurrent anxiolytic and sedative/hypnotic use during days 2-60 after antidepressant therapy initiation was 18.2%. CONCLUSION: The study suggests that patients in this Dutch sick fund were not likely to receive either adequate antidepressant doses or adequate durations of therapy relative to Dutch guidelines for the treatment of depression. These findings are consistent with findings in other Dutch, European, and US studies and may present opportunities for quality improvement.  (+info)

Amitriptyline and procainamide inhibition of cocaine and cocaethylene degradation in human serum in vitro. (5/3228)

Amitriptyline (AMI) and procainamide (PA) have been reported to inhibit the activity of human plasma butyrylcholinesterase, an enzyme important in the metabolic degradation of cocaine (COC) and its ethyl analogue cocaethylene (CE). Because both AMI and PA may be used in the treatment of COC intoxication and abuse, the effect of high pharmacological concentrations of these compounds on the degradation of COC and CE in pooled human serum was studied. AMI (1.8 micromol/L) modestly inhibited the degradation of COC by 4.2% and of CE by 4.0%. PA (42.5 micromol/L) profoundly inhibited degradation of COC by 42.7% and of CE by 47.2%. In contrast, lithium carbonate (1 mmol/L, control) showed no inhibition of degradation of either COC or CE. These results suggest that AMI and PA may prolong the half-life of COC and CE in human serum.  (+info)

Drug-induced heart failure. (6/3228)

Heart failure is a clinical syndrome that is predominantly caused by cardiovascular disorders such as coronary heart disease and hypertension. However, several classes of drugs may induce heart failure in patients without concurrent cardiovascular disease or may precipitate the occurrence of heart failure in patients with preexisting left ventricular impairment. We reviewed the literature on drug-induced heart failure, using the MEDLINE database and lateral references. Successively, we discuss the potential role in the occurrence of heart failure of cytostatics, immunomodulating drugs, antidepressants, calcium channel blocking agents, nonsteroidal anti-inflammatory drugs, antiarrhythmics, beta-adrenoceptor blocking agents, anesthetics and some miscellaneous agents. Drug-induced heart failure may play a role in only a minority of the patients presenting with heart failure. Nevertheless, drug-induced heart failure should be regarded as a potentially preventable cause of heart failure, although sometimes other priorities do not offer therapeutic alternatives (e.g., anthracycline-induced cardiomyopathy). The awareness of clinicians of potential adverse effects on cardiac performance by several classes of drugs, particularly in patients with preexisting ventricular dysfunction, may contribute to timely diagnosis and prevention of drug-induced heart failure.  (+info)

The effects of detection and treatment on the outcome of major depression in primary care: a naturalistic study in 15 cities. (7/3228)

BACKGROUND: This study reports the responses of patients with confirmed depressive illnesses to different treatments in the WHO Mental Disorders in General Health Care study, conducted in 15 cities around the world. AIM: To discover how depressions recognized by the doctor compare with unrecognized depressions, both in terms of the initial illnesses and their outcomes, and to compare the outcomes of those depressions treated with antidepressants with those treated with daytime sedatives. METHOD: The design of the study was naturalistic, in that physicians were free to treat patients however they wished. Patients with confirmed depressive illnesses were assigned to four groups: treatment with an antidepressant; treatment with a daytime sedative (usually a benzodiazepine); patients recognized as having depression by the physician but were not offered drug treatment; and patients unrecognized as having depression by their physician. RESULTS: Both groups receiving drugs had illnesses of equal severity, were demographically similar to one another, and had similar previous histories of depression. Those receiving antidepressants had significantly fewer overall symptoms and fewer suicidal thoughts than those treated with sedatives. By the end of one year, differences between the groups had disappeared: patients not given drugs had milder illnesses but did significantly better than those receiving drugs, both in terms of symptoms lost and their diagnostic status. Unrecognized depressions were less severe than recognized depressions, and had a similar course over the year. CONCLUSIONS: Patients receiving antidepressants were better in terms of overall symptoms and suicidal thoughts than those treated with sedatives at three months, but this advantage does not persist. Depression emerges as a chronic disorder at one-year follow-up--about 60% of those treated with drugs, and 50% of the milder depressions, still meet criteria for caseness. The study does not support the view that failure to recognize depression has serious adverse consequences, but, in view of the poor prognosis of depression, measures to improve compliance with treatment would appear to be indicated.  (+info)

Depressive state with anxiety in repeated cold-stressed mice in forced swimming tests. (8/3228)

The effects of various types of stress and drugs were studied to assess mouse performance in forced swimming tests, following characterization of SART (specific alternation of rhythm in environmental temperature) stress. Immobility time in the test decreased in mice subjected to SART, acute cold and restraint stress. No change was noted due to chronic cold stress or repeated fasting. The shortened time did not recover even 24 hr after the end of SART and chronic restraint stress. The time in SART-stressed mice finally recovered at 5-7 days. Shortening of immobility time in SART-stressed mice was inhibited by diazepam and repeated imipramine but not by lithium carbonate. In chronic restraint-stressed mice, this time was inhibited by repeated lithium carbonate but not diazepam or imipramine. SART stress would thus appear related to anxiety and depression and may be useful for detecting new types of antidepressants.  (+info)

TY - JOUR. T1 - Acute Amino Acid d -Serine Administration, Similar to Ketamine, Produces Antidepressant-like Effects through Identical Mechanisms. AU - Wei, I. Hua. AU - Chen, Kuang Ti. AU - Tsai, Mang Hung. AU - Wu, Ching Hsiang. AU - Lane, Hsien Yuan. AU - Huang, Chih Chia. PY - 2017/12/13. Y1 - 2017/12/13. N2 - d-Serine is an amino acid and can work as an agonist at the glycine sites of N-methyl-d-aspartate receptor (NMDAR). Interestingly, both types of glutamatergic modulators, NMDAR enhancers and blockers, can improve depression through common targets, namely alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionaic acid receptors (AMPARs) and mammalian target of rapamycin (mTOR). To elucidate the cellular signaling pathway underlying this counterintuitive observation, we activated NMDARs in rats by using d-serine. Saline, ketamine (NMDAR antagonist), and desipramine (tricyclic antidepressant) were used as controls. The antidepressant-like effects of all agents were evaluated using the forced ...
TY - JOUR. T1 - Carbamoylated erythropoietin produces antidepressant-like effects in male and female mice. AU - Sampath, Dayalan. AU - McWhirt, Joshua. AU - Sathyanesan, Monica. AU - Newton, Samuel S.. PY - 2020/1/10. Y1 - 2020/1/10. N2 - Major depressive disorder and related illnesses are globally prevalent, with a significant risk for suicidality if untreated. Antidepressant drugs that are currently prescribed do not benefit 30% of treated individuals. Furthermore, there is a delay of 3 or more weeks before a reduction in symptoms. Results from preclinical studies have indicated an important role for trophic factors in regulating behavior. Erythropoietin (Epo), which is widely prescribed for anemia, has been shown to produce robust neurotrophic actions in the CNS. Although Epos antidepressant activity has been successfully demonstrated in multiple clinical trials, the inherent ability to elevate RBC counts and other hematological parameters preclude its development as a mainstream CNS drug. A ...
A study of older suicide victims by researchers at Weill Cornell Medical College in New York has found that very few of them - less than a quarter - were taking antidepressants at the time of their death. The study of 255 suicide victims who were all over 65 and who killed themselves between 2001 and 2004 found that only 23% of the sample had been taking antidepressants at the time of their death. Only 16.7% of those over 85 had been taking antidepressants ...
The mechanism underlying the therapeutic effect of antidepressants is not known but neuroadaptive processes akin to long-term potentiation have been postulated. Arc (Activity-regulated, cytoskeletal-associated protein) is an effector immediate early gene implicated in LTP and other forms of neuroplasticity. Recent data show that Arc expression is regulated by brain 5-hydroxytryptamine neurones, a target of many antidepressants. Here in situ hybridisation and immunohistochemistry were used to examine whether Arc expression in rat brain is altered by antidepressant drug treatment. Repeated administration of the monoamine reuptake inhibitors paroxetine, venlafaxine or desipramine induced region-specific increases in Arc mRNA. These increases were greatest in regions of the cortex (frontal and parietal cortex) and hippocampus (CA1 layer) and absent in the caudate putamen. Repeated treatment with the monoamine oxidase inhibitor, tranylcypromine, increased Arc mRNA in a similar fashion to the monoamine
This study suggested that living alone is associated with the prospective use of antidepressant medication in a nationally representative Finnish working-age sample. Those who lived alone had an 80% higher risk of initiating antidepressant use during the 7-year follow-up compared with participants who did not live alone. Socioeconomic adversity explained part of this relationship, especially in women. Psychosocial factors, including a lack of social support, were important explanatory factors in men. Health behaviors had only a marginal contribution to the association between living alone and antidepressant use among men and women, with the exception of heavy alcohol use in men. This is in agreement with a previous register-based study showing a strong link between living alone and alcohol-related mortality [36]. All the factors included in this study explained 46% of the associations, thus leaving the majority of the association between living alone and antidepressant use unexplained.. Our ...
Dont be surprised if a doctor prescribes an antidepressant medication to treat a condition totally unrelated to depression. Certain medical conditions and/or the symptoms caused by them are responding well to treatment with antidepressant medications. These are a few conditions for which a patient might be prescribed an antidepressant medication and why the medication works for these conditions.. Cymbalta (Duloxetine) Helps Ease Diabetic Nerve Pain. The antidepressant medication, Cymbalta, helps ease the pain of diabetic peripheral neuropathy and other chronic pain that some diabetics experience. The antidepressant medication works by adjusting the chemical response the brain is receiving regarding the nerve pain being felt. The chemical adjustment allows the pain to be perceived as less severe so the diabetic peripheral neuropathy eases in severity.. Prozac (Fluoxetine) Helps Prevent Binge Eating. Patients with an eating disorder that causes them to binge eat are often prescribed the ...
Vascular endothelial growth factor (VEGF) is a key player in the pathogenesis of neovascular age-related macular degeneration (nAMD) and is also involved in the final common pathway of antidepressant medication. This study investigated the relationship between the need for anti-VEGF retreatment in patients with nAMD and antidepressant medication, and the potential impact of ocular structural factors. Data from two identical prospective 2-year treatment protocols using ranibizumab or aflibercept in a variable-dosing regimen (Observe-and-Plan) were analysed. Retreatment requirement was compared with antidepressant medication intake (primary outcome) and a variety of ocular factors from baseline and from month 3 response (secondary outcomes), using univariate and multivariate analyses. Of the 206 included patients (227 eyes), 19 were on antidepressant medication. Their nAMD eyes significantly more often had pigment epithelium detachment (PED, p=0.04). Multivariate analysis revealed a si
Dysregulation of the glutamatergic system and its receptors in medial prefrontal cortex (mPFC) has been implicated in major depressive disorder. Recent preclinical studies have shown that enhancing NMDA receptor (NMDAR) activity can exert rapid antidepressant-like effects. AGN-241751, an NMDAR positive allosteric modulator (PAM), is currently being tested as an antidepressant in clinical trials, but the mechanism and NMDAR subunit(s) mediating its antidepressant-like effects are unknown. We therefore used molecular, biochemical, and electrophysiological approaches to examine the cell-type-specific role of GluN2B-containing NMDAR in mediating antidepressant-like behavioral effects of AGN-241751. We demonstrate that AGN-241751 exerts antidepressant-like effects and reverses behavioral deficits induced by chronic unpredictable stress in mice. AGN-241751 treatment enhances NMDAR activity of excitatory and parvalbumin-inhibitory neurons in mPFC, activates Akt/mTOR signaling, and increases levels of synaptic
HPLC Application #15029: Tricyclic Antidepressants at pH7.0. Column used: Gemini® 5 µm C18 110 Å, LC Column 150 x 4.6 mm, Ea Part#: 00F-4435-E0
Antidepressant initiation was more frequent among persons with Alzheimers disease already 9 years before the diagnosis than among comparison persons not diagnosed with Alzheimers disease. This finding was somewhat surprising. It may be related to more frequent treatment of depressive symptoms because depression has been associated with an increased risk of Alzheimers disease in previous studies.. Antidepressant use was investigated in the Finnish nationwide MEDALZ study from 9 years before until 4 years after the diagnosis of Alzheimers disease. The difference in antidepressant initiations persisted during the entire follow-up period. During the 13-year follow-up period, 42% of persons with Alzheimers disease and 22% of persons not diagnosed with the disease initiated antidepressant use. The most commonly used antidepressant group was selective serotonin reuptake inhibitor (SSRI) drugs, followed by mirtazapine.. The register-based study was based on 62,104 Finnish persons with Alzheimers ...
University of Adelaide researchers have found that women on antidepressant medication are more successful at breastfeeding their babies if they keep taking the medication, compared with women who quit antidepressants because of concerns about their babies health.. These results have been presented this week at the 18th Perinatal Society of Australia and New Zealand (PSANZ) Annual Conference in Perth.. Using data from the Danish National Birth Cohort in Denmark, researchers in the University of Adelaides Robinson Research Institute studied the outcomes of 368 women who were on antidepressants prior to becoming pregnant.. We found that two thirds of the women (67%) stopped taking their antidepressant medication either after becoming pregnant or during breastfeeding, says NHMRC Early Career Fellow Dr Luke Grzeskowiak from the Robinson Research Institute.. A third of the women (33%) continued to take antidepressant medication throughout their pregnancy and while breastfeeding, and these women ...
The problem of interest. Depression is a common serious illness, with great personal suffering and a 10% or more risk of suicide. There are two kinds of depression, bipolar (depression alternating with mood swings) and unipolar (simple depression, or major depressive disorder). In both kinds of depression, antidepressants are commonly used. However, unlike unipolar depression, where a good deal of research supports this use, there is very little research on antidepressant use in bipolar disorder. Some studies support benefit with antidepressants for bipolar depression; i.e., if one is depressed, antidepressants can help a patient get better in the short-term. However, long-term studies are limited; the few available studies with older antidepressants did not demonstrate long-term preventive benefit. Some clinicians think new generation antidepressants (like Prozac and other serotonin reuptake inhibitors) are safer and more effective than the older antidepressants. Yet there are no rigorous ...
BACKGROUND: Conventional meta-analyses have shown inconsistent results for efficacy of second-generation antidepressants. We therefore did a multiple-treatments meta-analysis, which accounts for both direct and indirect comparisons, to assess the effects of 12 new-generation antidepressants on major depression. METHODS: We systematically reviewed 117 randomised controlled trials (25 928 participants) from 1991 up to Nov 30, 2007, which compared any of the following antidepressants at therapeutic dose range for the acute treatment of unipolar major depression in adults: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, mirtazapine, paroxetine, reboxetine, sertraline, and venlafaxine. The main outcomes were the proportion of patients who responded to or dropped out of the allocated treatment. Analysis was done on an intention-to-treat basis. FINDINGS: Mirtazapine, escitalopram, venlafaxine, and sertraline were significantly more efficacious than duloxetine (odds ratios
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New research published in the BMJ studies the association between antidepressant use during pregnancy and autism.. A roundup accompanied this analysis.. Title, Date of Publication & Journal. Antidepressants during pregnancy and autism in offspring: population based cohort study. Published: Wednesday 19 July. BMJ. Studys main claims - and are they supported by the data. The study claims there is a small association between antidepressant use in pregnancy and autism without intellectual disability. This claim is plausible given the evidence presented in the paper. The study finds no link between antidepressant use and autism with intellectual disability.. The study does not claim that antidepressant use causes autism, and there is no evidence in the paper to support such a claim.. Although the association is statistically robust, the number of children this affects is very small - around 1 in every 100 babies born to a mother on antidepressants. Additionally none of the excess cases of autism ...
While delayed onset of antidepressant action remains a shortcoming of current antidepressants, preliminary clinical data with newer antidepressants, including mirtazapine, show promise for a hastened onset. Several potential mechanisms have been postulated and investigated. Mirtazapine displays serotonin 5-HT2 and 5-HT3, receptor blocking properties, while its putative earlier onset of action is thought to be related to its 2-adrenoceptor lytic action (at 2-adrenergic autoreceptors and heteroreceptors), thereby modulating central serotonergic and noradrenergic neurotransmission. The current study investigated the role of 2-adrenoceptor antagonism for earlier onset of action in a rat model of depression. First of all, the treatment period necessary to produce antidepressant-like responses with fluoxetine (an antidepressant with a delayed onset of action) was established. Rats were treated for 3, 7, and 11 days with fluoxetine, whereafter the forced swim test (FST) was employed and ...
Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. There has been a long-standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist ...
Psychiatrists most commonly prescribe antidepressants for bipolar depression, but mounting evidence shows that the traditional antidepressants that are effective in unipolar depression are not effective in bipolar disorder. At the 2013 meeting of the American Psychiatric Association, researcher Jessica Lynn Warner reported that among 377 patients with Bipolar I Disorder who were discharged from a hospital, those who were prescribed an antidepressant at discharge were just as likely to be remitted for a new depression than those not given an antidepressant.. The average time to readmission also did not differ across the two groups and was 205 +/- 152 days. Those patients prescribed the serotonin and norepinephrine reuptake inhibitor (SNRI) drug venlafaxine (Effexor) were three times more likely to be readmitted than those not prescribed antidepressants.. These naturalistic data (generated from observations of what doctors normally do and information in the hospitals clinical notes) resemble ...
Hello fellow fasters, I m taking 60mg of fluoxetine and 15mg of mirtazapine daily. My depression has become severe recently and I now realise that taking antidepressants is not going to help me long term so I ve reached a point where I have to try something different. I watched The science of fasting on YouTube and was intrigued and excited that water only fasting had had positive effects on mental health in a clinical setting. Since then I ve done a lot of research and found only one possible contraindication that applied to me: that I m on AD. I can t stop them cold turkey so af ...
National Institute of Mental Health. Depression is a serious disorder that can cause significant problems in mood, thinking, and behavior at home, in school, and with peers. It is estimated that major depressive disorder (MDD) affects about 5 percent of adolescents, who have more frequent suicidal thinking and behavior and greater likelihood of substance abuse than youth in general.. Research has shown that, as in adults, depression in children and adolescents can be treated. In particular, antidepressant medications - called selective serotonin reuptake inhibitors (SSRIs) because they specifically target the neurotransmitter serotonin - have been shown to be of benefit to children and adolescents with major depressive disorder. Certain types of psychological therapies have also been shown to be beneficial. In those with moderate to severe depression they are especially useful when combined with medication. Our knowledge of antidepressant treatments in youth, though growing substantially, ...
Given that both clinical and preclinical studies suggest that BDNF may be involved in the therapeutic action of antidepressants, BDNF appears to be a good candidate gene for the pharmacogenetic study of antidepressants. In our 2003 study on 110 MDD outpatients, we examined the association between the BDNF Val66Met polymorphism and response to 4-week antidepressant (fluoxetine) treatment.17 A trend (p=0.086) to higher total HAM-D-score percentage change was noted for the Val/Met-heterozygote patients in comparison to those bearing the homozygote (Val/Val or Met/Met). While similar findings have been reported in some of the subsequent studies of this polymorphism and the antidepressant response23,24, other studies demonstrated a better response in subjects with the Met variant25-27 or they found no association at all (Table 1).28,29 The inconsistencies in these findings might be due to the small sample sizes used in some of the studies. They could also have arisen as the result of differences in ...
Major depressive disorder (MDD) is one of the most common psychiatric disorders and its origin has been attributed to dysfunction of the monoamine systems, particularly noradrenergic and serotonergic, making them the main targets of the majority of antidepressants currently available. However a number of unmet clinical needs remain, such as a delay of several weeks from the first treatment to manifest antidepressant effects, low remission rates and high rates of relapse and recurrence. Fast acting antidepressant activity and efficacy in treatment-resistant cases has been reported with drugs that inhibit the glutamate N-methyl-D-aspartic acid (NMDA) receptor. However, this pharmacological approach is problematic, as it leads to motor and psychotic side effects. Inhibitors of nitric oxide synthase (NOS), a downstream target of NMDA receptors, produce antidepressant effects in the Porsolt test of antidepressant activity in laboratory rodents, without the adverse effects associated with NMDA ...
I been on antidepressant for over a year was on prozac and was changed to welbutrin 3 months ago. Im worried about being on medication while pregnant. Does anyone take medication and had there baby wi...
From 1999 to 2012 the percentage of Americans on antidepressants increased from 6.8% to 13%, according to a report published this week by the Journal of th
Marina Picciotto - Depression is a debilitating illness that is highly prevalent in the United States and up to 50% of patients with major depression are non:responsive to current antidepressant medications. Based on our basic science studies of the role of acetylcholine in pathways underlying depression:like behavior in rodents, our laboratory has identified nicotinic acetylcholine receptors (nAChRs) as a key target for development of novel antidepressant medications. We have established collaborations with a chemist (Dr. Daniela Gundisch, University of Hawaii) who has synthesized a number of new nicotinic partial agonists that target specific subtypes of nAChRs. In collaboration with an electrophysiologist (Dr. Roger Papke, University of Florida) we have characterized the selectivity of these compounds and our lab has shown that they are effective in animal models of antidepressant:efficacy. As a proof of principle, we have shown that nicotinic agents already approved for use in human subjects ...
By contrast, the risk of antidepressant treatment is small. A 2004 review by the Food and Drug Administration, analyzing clinical trials of the drugs, did show an elevated risk of suicidal thinking and nonlethal suicide attempts in young people taking antidepressants - 3.5 percent, compared with 1.7 percent of those taking a placebo. But since the lifetime risk of actual suicide in depressed people ranges from 2.2 to 12 percent, risk from treatment is dwarfed by the risks of the disease itself ...
Knowledge of how different antidepressants are likely to affect parameters of sleep can provide an important basis for selecting an appropriate antidepressant drug among the roughly 2 dozen marketed options to meet the needs of depressed patients. 1
Date Created: about 1998. Preface to old edition. Most of the SNRIs that have been on the market have failed to show antidepressant effect in most trials. This drug is a reminder of that, it was initially developed as an antidepressant before those failed trials and its subsequent resurrection as an anti-obesity drug. It was removed from the market for reasons that were probably somewhat spurious.. Another example is duloxetine which was developed around the same time, failed as an antidepressant, was shelved, was resurrected as incontinence prevention drug, and then eventually recycled successfully as an antidepressant!. Milnacipran was developed by a small French company (in the 1980s I think) and never gained acceptance as an effective antidepressant anywhere else, I do not know what trials were done unsuccessfully, one never does, and it was only after a company takeover that the levo-isomer was successfully marketed in the USA in 2013 as Fetzima. I do not know what kind of strange image ...
By Melania Zaharopoulos. The prescription drug market is awash in medications marketed for the treatment of depression with what could be as many as 30 common prescriptions on the market today, said Dr. Shan Crockett, a Santa Cruz psychiatrist who assists with a Hollister-based geriatric mental health program two days per week.. And while a wide variety of options are available, selecting the right prescription for each patient is a balancing act that takes into account symptoms, state of mind and family history before signing off a prescription.. œSome depressions are really agitated and some are really slow,? said Crockett. œWe would think about that, about whether there was a sleep problem involved or whether there were other things going on.. œWhen folks are very depressed, they still want to have sex. They come in and say, ˜Is this going to affect my drive?™ The other thing is ease of administration. Is it once a day? Three times a day? Do you go up in dosage once or is it a long ...
Health,A commonly used antidepressant may help women who suffer from premenst...Doctors from the University of Pennsylvania Medical Center in Phil...A total of 15 women were included in this study. They were chosen ...Authors of the study conclude These results from a small number ......,New,therapy,for,PMS,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
The duration of untreated illness has been considered a likely predictor of the course of psychotic disorders. However, there is only sparse data concerning the influence of treatment delay on the outcome of mood disorders. The present study aimed to assess the effect of prolonged untreated depression on the outcome of antidepressant treatment ...
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Antidepressants can help correct the anomalies and treat depression by curbing the symptoms slowly. To know more about different types of antidepressants, click here.
After the risk disclosure and boxed warning by the FDA were released in 2003 and 2004, there was substantial media coverage on the dangers of antidepressants in youth and anecdotal cases of antidepressant-related suicides in children.9 Several studies found major reductions in the diagnosis of depression and prescription of antidepressants to children, adolescents, and adults.11-14 Libby et al14 reported that, among primary care providers, there was a 44% decrease in the diagnosis rate of depression in children and adolescents younger than 18 years, a 37% decrease in young adults, and a 29% decrease in adults after the boxed warning was released. Prescription of antidepressants decreased, while the use of treatment alternatives such as anxiolytics, atypical antipsychotics, and child psychotherapy did not change considerably. According to Gibbons et al,15 rates of antidepressant prescriptions for children decreased by 20% after the warnings were released in 2003 and 2004. These findings ...
Major depressive disorder (MDD) is a chronic condition that affects one in six adults in the US during their lifetime. The current practice of antidepressant medication prescription is a trial-and-error process. Additionally, over a third of patients with MDD fail to respond to two or more antidepressant treatments. There are no valid clinical markers to personalize currently available antidepressant medications, all of which have similar mechanisms targeting monoamine neurotransmission. The goal of this review is to summarize the recent findings of immune dysfunction in patients with MDD, the utility of inflammatory markers to personalize treatment selection, and the potential of targeting inflammation to develop novel antidepressant treatments ...
Background Antidepressant medication is commonly used to treat depression. However, many patients do not respond to the first medication prescribed and improvements in symptoms are generally only detectable by clinicians 4-6 weeks after the medication has been initiated. As a result, there is often a long delay between the decision to initiate an antidepressant medication and the identification of an effective treatment regimen. Previous work has demonstrated that antidepressant medications alter subtle measures of affective cognition in depressed patients, such as the appraisal of facial expression. Furthermore, these cognitive effects of antidepressants are apparent early in the course of treatment and can also predict later clinical response. This trial will assess whether an electronic test of affective cognition and symptoms (the Predicting Response to Depression Treatment Test; PReDicT Test) can be used to guide antidepressant treatment in depressed patients and, therefore, hasten ...
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Ive been taking Lamictal (150 mgs) and Welbutrin (100 mgs) for over a year. About eight months or so ago, I started taking Celexa (10 mgs) as well. Since taking the Celexa, Ive gained over ten pounds, this after staying at the same weight for over three years. Im still going to the gym six days a week and my diet hasnt significantly changed. The next time I see my doctor, Id like to suggest he take me off the Celexa and put me on a different anti-depressant. Can anyone tell me which anti-depressant is least likely to cause weight gain ...
Marc Siegel, M. In clinical practice, not only gynecologists but also generalists are often asked to solve specific questions about sexual diseases. In fact, encouraging results were achieved in specific groups of patients affected by secondary FSADs eg, diabetes mellitus, multiple sclerosis, chronic antidepressant users in which the genital arousal disorder is clearly connected with a neurological or vascular injury. Experts recommend that you stop taking the drug if you dont notice an improvement in your sex drive after eight weeks. Review by Single-blind. Received 16 July In fact, genital congestion and lubrication strictly depend on the hormonal balance ie, arousal disorders during the menopausal transition and require adequate vascular function and an efficient nerve transmission of mechanical stimuli. Absence of or markedly diminished feelings of sexual arousal sexual excitement and sexual pleasure from any type of sexual stimulation as well as complaints of absent or impaired genital ...
SSRIs include: Celexa; Prozac; Paxil; Zoloft; Lexapro; Luvox. Here are quotes from other Psychiatric News articles about SSRI use and bleeding...
Autism and the number of women taking antidepressant during pregnancy have increased. Is there a link between autism and maternal antidepressant use?
Not sure if this is the right place but I figured people might be interested in possible theories as to what causes MND. Looking back I took antihistamines almost every day for 16 years and was on many different antidepressants over the years and now Im sure all that affected my brain. I was getting brain zaps for many years even when I hadnt had any SSRI meds for years. The zaps were awful and sounded like neurons firing and drs couldnt explain it. Had MRI in 2017 and they couldnt find a cause. Since my motor related symptoms reared their ugly head I havent had the zaps. Did I cause this with all the medications? Im sure one day they will find out that taking a lot of antihistamines and antidepressants can cause it. Its devastating enough without thinking I might have done it to myself ...
Common antidepressants are medications that help people to cope with depressive states. They appeared in late 50s of the last century and up to date remain the main remedy to fight depression.. In addition to treatment of depression, common antidepressants can be used for the treatment of other mental disorders. For instance, anxiety disorder, posttraumatic stress disorder, agoraphobia and social phobia.. Today, people can buy common antidepressants without prescription at any pharmacy. These drugs help to eliminate the anxiety, depression and normalize sleep. Such medical agents affect the serotonin and norepinephrine metabolism in the brain and stimulate the human psyche.. Lately, depression has become a common disorder among teenagers. The cases of mild depression in teens are cured with herbal antidepressants. Effective herbal common antidepressants for teenagers are widely available in large quantities at pharmacies.. Such drugs can effectively cope with anxious and depressive states, ...
Individuals with late-life depression (LLD) experience high levels of disability, mortality, and poor responses to antidepressants. The MRI hallmark of vascular depression in this population is significant ischemic white matter lesion (WML) severity, a finding associated with poor antidepressant outcomes. Despite observations of diffuse white matter disease in LLD, we propose in our disconnection hypothesis that focal damage to fiber tracts negatively affects the function of connected regions, resultantly contributing to cognitive deficits and clinical symptoms such as depression severity and negativity bias. Focal WMLs may also reduce the likelihood of an antidepressant response when the specific antidepressant used acts on neurotransmitter systems projecting through the damaged fiber tract. This implies that the effect of tract damage on clinical response may differ between drugs with different mechanism of action.. We propose that the cingulum bundle (CB) and uncinate fasciculus (UF) are ...
Taking antidepressants may raise the risk of heart disease in men by producing a thickening of artery walls, researchers said Saturday. Although a potential mechanism for the action is not obvious,
This succulent herb from South Africa was once used as a bartering currency, according to written records that date back to the 1600s. Since then it has made its way to North America and has been embraced for its reported antidepressant properties, including its ability to help elevate mood and promote relaxation and a sense of well being.. Sceletium contains alkaloids that interact with receptors in the brain, affecting the release of dopamine (a compound that affects pleasure) and serotonin (a compound that affects mood). After you take it, you will feel its effects in about half an hour, and it feels great, says Chris Kilham, a researcher and author also known as the Medicine Hunter. The herb produces an increased sense of clarity and an enhanced capacity for ideas and mental focus, he says. Sceletium may also be useful in decreasing anxiety, stress and tension.. The alkaloids in sceletium act much like the pharmaceutical antidepressants known as selective serotonin reuptake inhibitors ...
Depression is common in women of childbearing age, and in Europe 3-8% of pregnant women are prescribed antidepressants during pregnancy.1 The fetal safety of antidepressant exposure during pregnancy has generated much debate after recent concerns of a possible association with autism in exposed offspring. In the past five years, several epidemiological studies2 3 4 5 6 7 8 9 10 11 have assessed the relation between antidepressant use during pregnancy and autism in offspring, but robust conclusions have been elusive.12 13 Although most studies found evidence of unadjusted associations, conclusions differed because of concerns about confounding by indication. This was because depression or other psychiatric indications for antidepressant use could be associated with autism through genetic or non-genetic pathways, and thus the possibility of the observed associations representing the risk of autism from the underlying indication for prescription could not be ruled out.. All antidepressants cross ...
SSRIs are not as effective for pain relief as SNRIs.. Even though the antidepressants may help diminish pain, their side effects can be unacceptable. A recent review found that although approximately 1/3 of patients who took antidepressants for neuropathic pain experienced moderate pain relief or better, 1/5 discontinued use due to adverse side effects.[1]. Common side effects of antidepressants are nausea, dizziness, insomnia, weight gain/loss, dry mouth and diminished interest in sex (decreased libido). If youre not having reasonable pain relief with one of these medications, it should not be continued.. ...
Depression, or more accurately, un-repaired emotional short-circuiting, can absolutely devastate your health and life. However, using antidepressants as the primary (or only) treatment option is simply not advisable, especially if the one suffering from depression is a child or teenager. Whereas severe depression can indeed progress to suicide if left untreated, antidepressant drugs have been shown to CAUSE both suicidal and homicidal thoughts and behaviors. As mentioned in the featured report, at least 11 tragic school shootings were done by children who were either on antidepressants, or going through withdrawal…. I believe this is an enormous price to pay for what amounts to highly questionable benefits.. Studies have found that up to 75 percent of the benefits of antidepressants could be duplicated by a placebo. So not only do these drugs not work as advertised, but the evidence is quite clear that most of these drugs do in fact increase your risk of suicide and violence. Since depression ...
Depression is a debilitating chronic illness that affects around 350 million people worldwide. Current treatments, such as selective serotonin reuptake inhibitors, are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown …
Lingjaerde O (November 1971). "[Imiprex "Dumex" (imipramine oxide). A new tricyclic antidepressive agent]". Tidsskrift for den ... preliminary investigation of a new antidepressive drug". The American Journal of Psychiatry. 120 (3): 277-8. doi:10.1176/ajp. ...
"Sertraline versus other antidepressive agents for depression". The Cochrane Database of Systematic Reviews (4): CD006117. doi: ... While imprecise, comparison of the results of trials of sertraline with separate trials of other anti-panic agents ( ... Central Nervous System Agents in Medicinal Chemistry. 9 (3): 197-204. doi:10.2174/1871524910909030197. PMID 20021354. Kobayashi ...
"Mirtazapine versus other antidepressive agents for depression". Cochrane Database of Systematic Reviews (12): CD006528. doi: ... Other agents impacting the central nervous system in sufficient or toxic doses Quantifying sleepiness requires a careful ...
"Milnacipran versus other antidepressive agents for depression". The Cochrane Database of Systematic Reviews. 8 (3): CD006529. ... acceptability and tolerability when comparing milnacipran with other antidepressant agents. However, compared with TCAs, ...
"Citalopram versus other anti-depressive agents for depression". The Cochrane Database of Systematic Reviews (7): CD006534. doi: ... Like other serotonergic agents, SNRIs have the potential to cause serotonin syndrome, a potentially fatal systemic response to ... Overdose of an SSRI or concomitant use with another agent that causes increased levels of serotonin can result in serotonin ...
"Fluvoxamine versus other anti-depressive agents for depression". The Cochrane Database of Systematic Reviews (3): CD006114. doi ... Silver H (2001). "Fluvoxamine as an adjunctive agent in schizophrenia". CNS Drug Reviews. 7 (3): 283-304. doi:10.1111/j.1527- ... Central Nervous System Agents in Medicinal Chemistry. 9 (3): 197-204. doi:10.2174/1871524910909030197. PMID 20021354. ...
"Agomelatine versus other antidepressive agents for major depression". The Cochrane Database of Systematic Reviews (12): ... "Agomelatine versus other antidepressive agents for major depression". The Cochrane Database of Systematic Reviews (12): ...
"Paroxetine versus other anti-depressive agents for depression". The Cochrane Database of Systematic Reviews (4): CD006531. doi: ... See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine ... Focus on Antidepressants and Atypical Antipsychotic Agents". P & T. 37 (1): 32-8. PMC 3278188. PMID 22346334.. ...
Galbaud du Fort, G. (1988). "Hematologic toxicity of antidepressive agents" [Hematologic Toxicity of Antidepressive Agents]. ... See also: Receptor/signaling modulators • Monoamine releasing agents • Adrenergics • Dopaminergics • Serotonergics • Monoamine ... Hoffmann, I; Ehrhart, G; Schmitt, K (1971). "8-amino-4-phenyl-1,2,3,4-tetrahydroisoquinolines, a new group of antidepressive ...
Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... Gram LF (September 1994). "[Antidepressive drug therapy, suicidal ideation and suicide, 2 cases reported in connection with ... moclobemide has been recommended as a first line agent for the treatment of depression in the elderly.[55] Due to the side ... Intoxications with moclobemide as single agent are usually mild; however, when combined with tricyclic or SSRI antidepressants ...
Tricyclic+Antidepressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH). ... having been replaced by more effective agents with fewer side effects such as atomoxetine (Strattera, Tomoxetin) and stimulants ...
"Paroxetine versus other anti-depressive agents for depression". The Cochrane Database of Systematic Reviews (4): CD006531. doi: ...
... a new antidepressive agent, in rats and dogs". Drug Metabolism and Disposition. 9 (3): 233-9. PMID 6113932. Depin JC, Betbeder- ... Norepinephrine reuptake inhibitor David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0 ...
Second-Generation+Antidepressive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) Diagrams at ...
MeSH Tricyclic+Antidepressive+Agents. *More information on TCAs. *v. *r. *u. Antidepresivi (N06A) ...
Selectivity of antidepressant agents are based on the neurotransmitters that are thought to influence symptoms of depression.[ ... Venlafaxine was the first compound described in a new class of antidepressive substances called phenylethylamines. These ... Agents with dual serotonin and norepinephrine reuptake inhibition (SNRIs) are sometimes called non-tricyclic serotonin and ... Combination of mechanisms of action in a single active agent is an important development in psychopharmacology.[28] ...
... a potential antidepressive drug". Psychopharmacology. 52 (1): 73-7. doi:10.1007/BF00426603. PMID 403562. S2CID 23960347. ... a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities". Biochemical Pharmacology. 25 ...
Ergoline-derived agents, bromocriptine and cabergoline are mostly used in treatment. Research shows that these agents reduce ... further research is crucial to establish the anti-depressive effects of dopamine agonists in treating depressive symptoms and ... Dopamine agonists are divided into two subgroups or drug classes, first-generation and newer agents. Ergoline derived agonists ... dopamine reuptake inhibitors and dopamine releasing agents. The most commonly prescribed indirect agonists of dopamine ...
Risk of overdose is increased in patients taking multiple serotonergic agents or interacting agents. ... Venlafaxine was the first compound described in a new class of antidepressive substances called phenylethylamines. These ... Agents with dual serotonin and norepinephrine reuptake inhibition (SNRIs) are sometimes called non-tricyclic serotonin and ... Combination of mechanisms of action in a single active agent is an important development in psychopharmacology.[35] ...
... antidepressive agents MeSH D27.505.954.427.700.122.050 - antidepressive agents, second-generation MeSH D27.505.954.427.700.122. ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Additionally, "adrafinil is known to a larger nonscientific audience, where it is considered to be a nootropic agent." ... As such, "further investigations of the antidepressive effects of adrafinil are warranted." Armodafinil CRL-40,940 CRL-40,941 ... 20-. ISBN 978-3-88763-075-1. Milgram, Norton (1999). "Adrafinil: A Novel Vigilance Promoting Agent". CNS Drug Reviews. 5 (3): ... Milgram, Norton W.; Callahan, Heather; Siwak, Christina (September 1992). "Adrafinil: A Novel Vigilance Promoting Agent". CNS ...
The discovery of antidepressive action of ketamine in 2000 has been described as the single most important advance in the ... Ketamine is an option in children, as the sole anesthetic for minor procedures or as an induction agent followed by ... The main challenge with ketamine treatment is what to do when the anti-depressive action expires. The maintenance therapy with ... It is not clear whether ketamine alone is sufficient for the antidepressive action or its metabolites are also important. In ...
PDE4 inhibitors may have antidepressive effects and have also recently been proposed for use as antipsychotics. On October 26, ... The potential for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait ... Recent studies have shown Quinazoline type PDE7 inhibitor to be potent anti-inflammatory and neuroprotective agents. ... Weiss B.; Hait W.N. (1977). "Selective cyclic nucleotide phosphodiesterase inhibitors as potential therapeutic agents". Annu. ...
Risk of overdose is increased in patients taking multiple serotonergic agents or interacting agents. Symptoms of SNRI overdose ... Venlafaxine was the first compound described in a new class of antidepressive substances called phenylethylamines. These ... Agents with dual serotonin and norepinephrine reuptake inhibition (SNRIs) are sometimes called non-tricyclic serotonin and ... It is recommended to washout 4 to 5 half-lives of the serotonergic agent before using an MAO inhibitor. Some studies suggest ...
Thanawala V, Kadam VJ, Ghosh R (October 2008). "Enkephalinase inhibitors: potential agents for the management of pain". Curr ... In addition, opiorphin may exert anti-depressive and antipanic action. Therapeutic application of opiorphin in humans would ...
Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. p. 265. ISBN 978-0-412-46630-4. ... Moryl E, Danysz W, Quack G (June 1993). "Potential antidepressive properties of amantadine, memantine and bifemelane". ...
"Tutsan Agents Released". landcareresearch.co.nz. "Archived copy". Archived from the original on 2008-07-19. Retrieved 2008-09- ... In Spain, the infusion of the flowering aerial parts is used as an antidepressive and anxiolytic. In England, tutsan ointment ...
Although women with PCOS are far more likely to have depression than women without, the evidence for anti-depressive use in ... Although these agents have shown significant efficacy in clinical trials (for oral contraceptives, in 60-100% of individuals), ...
van Haelst IM, van Klei WA, Doodeman HJ, Kalkman CJ, Egberts TC (August 2012). "Antidepressive treatment with monoamine oxidase ... Compared to amphetamine, tranylcypromine shows low potency as a dopamine releasing agent, with even weaker potency for ... It is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively. ... alternative agents are recommended. Other studies have come to similar conclusions. Pharmacokinetic interactions with ...
ISBN 978-0-915274-23-9. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties ... Berger M, Gastpar M (1996). "Trimipramine: a challenge to current concepts on antidepressives". Eur Arch Psychiatry Clin ... Trimipramine should not be given with sympathomimetic agents such as epinephrine (adrenaline), ephedrine, isoprenaline, ...
Serotonin precursors as antidepressive agents: a review] were found in PRIME PubMed. Download Prime PubMed App to iPhone, iPad ... Serotonin Precursors as Antidepressive Agents: a Review]." Fortschritte Der Neurologie-Psychiatrie, vol. 51, no. 5, 1983, pp. ... Serotonin precursors as antidepressive agents: a review].. Fortschr Neurol Psychiatr. 1983 May; 51(5):176-82.FN ... Beckmann H, Kasper S. [Serotonin Precursors as Antidepressive Agents: a Review]. Fortschr Neurol Psychiatr. 1983;51(5):176-82. ...
Agomelatine versus other antidepressive agents for major depression. Download Prime PubMed App to iPhone, iPad, or Android ... Paroxetine versus other anti-depressive agents for depression.. *Duloxetine versus other anti-depressive agents for depression. ... "Agomelatine Versus Other Antidepressive Agents for Major Depression." The Cochrane Database of Systematic Reviews, 2013, p. ... Agomelatine Versus Other Antidepressive Agents for Major Depression. Cochrane Database Syst Rev. 2013 Dec 17;(12)CD008851. ...
Paroxetine versus other anti-depressive agents for depression. Major depression is a severe mental illness characterised by a ... 1. To determine the efficacy of paroxetine in comparison with other anti-depressive agents in alleviating the acute symptoms of ... 2. To review acceptability of treatment with paroxetine in comparison with other anti-depressive agents. ... 3. To investigate the adverse effects of paroxetine in comparison with other anti-depressive agents. ...
What is Antidepressive agents? Meaning of Antidepressive agents medical term. What does Antidepressive agents mean? ... Looking for online definition of Antidepressive agents in the Medical Dictionary? Antidepressive agents explanation free. ... Antidepressive agents , definition of Antidepressive agents by Medical dictionary https://medical-dictionary.thefreedictionary. ... redirected from Antidepressive agents). Also found in: Dictionary, Thesaurus, Encyclopedia. antidepressant. [an″te-, an″ti-de- ...
The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain ... A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on ... Antidepressive Agents. Known as: Antidepressant, Antidepressant Agent, Antidepressants Expand. Mood-stimulating drugs used ... Ketamine is a noncompetitive antagonist of N-methyl-d-asparate (NMDA) receptor and has been long used as an anesthetic agent in ...
Therefore, psychotropic agents having antianxiety or antidepressive action are expected to alleviate FD. We previously reported ... A Systematic Review of the Effectiveness of Antianxiety and Antidepressive Agents for Functional Dyspepsia. by Physicians ... Methods Articles were searched for in MEDLINE from 2003 to 2014 using terms related to antianxiety or antidepressive agents. ... A statistical analysis suggested a significant treatment effect of psychotropic agents having antianxiety or antidepressive ...
Contribution of electrophysiology to the study of tianeptine and other antidepressive agents].. @article{ ... Contribution of electrophysiology to the study of tianeptine and other antidepressive agents].}, author={A. Dresse and J. Scuv ...
Antidepressive Agents, Antidepressive Agents, Second-Generation, Citalopram, Cyclohexanols, Depression, Humans, Morpholines, ... Citalopram versus other anti-depressive agents for depression. Cipriani A., Purgato M., Furukawa TA., Trespidi C., Imperadore G ...
Antidepressive agents. Antidepressive and neuroleptic agents, although not reported to be effective, have a limited use in ... Gastrointestinal prokinetic agents. Part of the pathophysiology of anorexia nervosa is a delay in gastric emptying, which can ... These agents have been reported to reduce binge eating, vomiting, and depression and to improve eating habits, although their ...
INTRODUCTION: Nocturnal enuresis affects 15-20% of 5-year-old children, 5% of 10 year-old-children and 1-2% of people aged 15 years and over. Without treatment, 15% of affected children will become dry each year. Nocturnal enuresis is not diagnosed in children younger than 5 years, and treatment may be inappropriate for children younger than 7 years. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of interventions for relief of symptoms ...
Clomipramine, a tricyclic antidepressant, is the 3-chloro derivative of Imipramine. It was thought that tricylic antidepressants work exclusively by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: alpha-1 and beta-1 receptors are sensitized, alpha-2 receptors are desensitized (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain ...
Fourteen trials compared escitalopram with another SSRI and eight compared escitalopram with a newer antidepressive agent ( ... Some statistically significant differences favouring escitalopram over other antidepressive agents for the acute phase ... heterocyclics and newer agents in the acute-phase treatment of major depression. SEARCH STRATEGY: Electronic databases were ... including non-conventional agents such as hypericum) for patients with major depressive disorder (regardless of the diagnostic ...
... allocating participants with major depression to mirtazapine versus any other antidepressive agent. DATA COLLECTION AND ... review was to assess the evidence on the efficacy and acceptability of mirtazapine compared with other antidepressive agents in ... statistically significant and possibly clinically meaningful differences between mirtazapine and other antidepressive agents ... Mirtazapine has a unique mechanism of antidepressive action and is one of the commonly used antidepressants in clinical ...
Adults with an acute episode of major depressive disorder with at least one prior episode will be randomized to Antidepressive ... This pilot study will examine whether antidepressive medications plus one of three commonly available types of psychotherapy ... All patients will receive antidepressive medications (ADM), which will be prescribed according to a pre-defined protocol ... Efficacy of 18-Months of Antidepressive Medication Plus CBT or Dynamic or Supportive Psychotherapy for Recurrent Major ...
Sertraline versus other antidepressive agents for depression answers are found in the Evidence-Based Medicine Guidelines ... Escitalopram versus other antidepressive agents for acute depression * Agomelatine versus other antidepressive agents for major ... agents_for_depression. Sertraline Versus Other Antidepressive Agents for Depression [Internet]. In: Evidence-Based Medicine ... Sertraline versus other antidepressive agents for depression is a topic covered in the Evidence-Based Medicine Guidelines. To ...
Agomelatine versus other antidepressive agents for major depression. Giuseppe Guaiana, Sumeet Gupta, Debbie Chiodo, Simon J C ... Duloxetine versus other anti-depressive agents for depression. Andrea Cipriani, Markus Koesters, Toshi A Furukawa, Michela Nosè ... Citalopram versus other anti-depressive agents for depression. Andrea Cipriani, Marianna Purgato, Toshi A Furukawa, Carlotta ... Sertraline versus other antidepressive agents for depression. Andrea Cipriani, Teresa La Ferla, Toshi A Furukawa, Alessandra ...
Book; Format: print Publisher: New York : Viking, 1993Other title: Psychiatrist explores antidepressant drugs and the remaking of the self.Availability: Items available for loan: WHO HQ [Call number: QV 77.5 93KR] (1). ...
Antidepressive Agents Research. [x] Remove Focus on Antidepressive Agents. Filter by Study Type. Animal Study. ...
Pharmacological Actions : Antidepressive Agents : CK(2853) : AC(522). Additional Keywords : Plant Extracts : CK(11762) : AC( ... Anti-Stress and Anti-Depressive Effects of Spinach Extracts on a Chronic Stress-Induced Depression Mouse Model through Lowering ... These results suggest that spinach has anti-stress and anti-depressive properties by lowering CORT and increasing glutamate and ... These results suggest that spinach has anti-stress and anti-depressive properties by lowering CORT and increasing glutamate and ...
Effective Antidepressive Agents Tianeptine Sodium CAS 30123-17-2 FOB Price: US $ 1-3 / Piece. Min. Order: 10 Pieces ...
Antidepressive Agents. LinkOut - more resources. Full Text Sources. *Elsevier Science. Medical. *Pregnancy - Genetic Alliance ...
Antidepressive Agents/therapeutic use. *Depressive Disorder, Major/therapy*. *Electroconvulsive Therapy. *Female. *Follow-Up ...
Antidepressive Agents. Psychotropic Drugs. Antipsychotic Agents. Tranquilizing Agents. Central Nervous System Depressants. ... Dopamine Agents. Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. Serotonin 5-HT1 Receptor Agonists. ...
Antidepressive Agents. Psychotropic Drugs. Serotonin Uptake Inhibitors. Neurotransmitter Uptake Inhibitors. Membrane Transport ...
Antidepressive Agents. * Antidepressants. Disclaimer: Information presented in this database is not meant as a substitute for ...
Antidepressive Agents. Brexpiprazole. Psychotropic Drugs. Serotonin Agents. Neurotransmitter Agents. Molecular Mechanisms of ...
Serotonin Agents. Physiological Effects of Drugs. Antidepressive Agents, Second-Generation. Antidepressive Agents. Psychotropic ...
Antidepressive Agents / therapeutic use * Anxiety / complications * Anxiety / drug therapy* * Citalopram / adverse effects ...
Antidepressive Agents Grant support * R01 MH025478/MH/NIMH NIH HHS/United States ...
major depressive disorder, MDD, antidepressive agents, residual symptoms, depression, depression treatment. By following author ... L-Triiodothyronine (T3) has also been best studied as an augmentation agent of the TCAs and MAOIs [74], with few controlled ... The most commonly used combination agent is bupropion [75], and though its frequency of such usage probably exceeds the ... Henderson, D.C.; Doraiswamy, P.M. Prolactin-related and metabolic adverse effects of atypical antipsychotic agents. J. Clin. ...
  • Randomised controlled trials allocating adult participants with major depression to agomelatine versus any other antidepressive agent. (unboundmedicine.com)
  • 2. A pharmacologic agent used in treating depression. (thefreedictionary.com)
  • adjective Relieving depression noun An agent used to manage depression, anxiety, panic disorders. (thefreedictionary.com)
  • 2. An agent or medication used in treating depression. (thefreedictionary.com)
  • OBJECTIVES: To assess the evidence for the efficacy, acceptability and tolerability of escitalopram in comparison with tricyclics, other SSRIs, heterocyclics and newer agents in the acute-phase treatment of major depression. (ox.ac.uk)
  • AUTHORS' CONCLUSIONS: Some statistically significant differences favouring escitalopram over other antidepressive agents for the acute phase treatment of major depression were found, in terms of efficacy (citalopram and fluoxetine) and acceptability (duloxetine). (ox.ac.uk)
  • OBJECTIVES: The aim of the present review was to assess the evidence on the efficacy and acceptability of mirtazapine compared with other antidepressive agents in the acute-phase treatment of major depression in adults. (ox.ac.uk)
  • AUTHORS' CONCLUSIONS: Some statistically significant and possibly clinically meaningful differences between mirtazapine and other antidepressive agents were found for the acute-phase treatment of major depression. (ox.ac.uk)
  • This pilot study will examine whether antidepressive medications plus one of three commonly available types of psychotherapy used in the short-term treatment of depression can protect against the recurrence of depression if active treatment is extended to 18-months duration. (clinicaltrials.gov)
  • We propose to conduct a pilot study to determine the feasibility and provide estimates for a randomized controlled study of combined antidepressive medications plus one of three forms of psychotherapy in common use for adults with an acute episode of recurrent major depression. (clinicaltrials.gov)
  • Sertraline versus other antidepressive agents for depression is a topic covered in the Evidence-Based Medicine Guidelines . (unboundmedicine.com)
  • Evidence Central , evidence.unboundmedicine.com/evidence/view/EBMG/451625/all/Sertraline_versus_other_antidepressive_agents_for_depression. (unboundmedicine.com)
  • Duloxetine did not seem to provide a significant advantage in efficacy over other antidepressive agents for the acute-phase treatment of major depression. (qxmd.com)
  • No study has set out to evaluate the role of neurobiological agents in preventing depressive symptoms in older populations at risk of depression. (biomedcentral.com)
  • Unfortunately, we only found evidence comparing duloxetine with a handful of other active antidepressive agents and only a few trials per comparison were found (in some cases we retrieved just one trial). (qxmd.com)
  • We found evidence that compared agomelatine with only a small number of other active antidepressive agents, and there were only a few trials for each comparison, which limits the generalisability of the results. (cochrane.org)
  • The Cochrane library January 2010: (Intralipid, ti.ab OR lipsyn II.ti.ab,) AND (MeSH descriptor Antidepressive Agents, Tricyclic explode all trees) 0 results. (bestbets.org)
  • 1. To determine the efficacy of paroxetine in comparison with other anti-depressive agents in alleviating the acute symptoms of Major Depressive Disorder. (cochrane.org)
  • SELECTION CRITERIA: All randomised controlled trials comparing escitalopram against any other antidepressant (including non-conventional agents such as hypericum) for patients with major depressive disorder (regardless of the diagnostic criteria used). (ox.ac.uk)
  • Tianeptine is considered as an anti-depressive agent and is used for treatment of major depressive disorder. (tga.gov.au)
  • The present systematic review assessed the efficacy and tolerability profile of paroxetine in comparison with tricyclics (TCAs), SSRIs and newer or non-conventional agents. (cochrane.org)
  • We found 11 studies (overall 3304 participants) comparing duloxetine with one selective serotonin reuptake inhibitor (SSRI) (six studies versus paroxetine, three studies versus escitalopram and two versus fluoxetine), four studies (overall 1978 participants) comparing duloxetine with a newer antidepressants (three with venlafaxine and one with desvenlafaxine, respectively) and one study (overall 453 participants) comparing duloxetine with an antipsychotic drug which is also used as an antidepressive agent, quetiapine. (qxmd.com)
  • MAIN RESULTS: Fourteen trials compared escitalopram with another SSRI and eight compared escitalopram with a newer antidepressive agent (venlafaxine, bupropion and duloxetine). (ox.ac.uk)
  • The antidepressant agents were significantly more efficacious than the placebos, and venlafaxine was more efficacious than fluoxetine. (biomedcentral.com)
  • Venlafaxine (Effexor ® ) became the first agent in a category of antidepressants known as the SSNRIs. (clevelandclinicmeded.com)
  • Conclusion Our systematic review suggested that psychotropic drugs having antianxiety and antidepressive actions as a whole might be effective in alleviating FD symptoms, whereas those having only antidepressive action were not effective. (physiciansweekly.com)
  • As with other antidepressant agents, several weeks of therapy may be required before a clinical effect is seen. (drugbank.ca)
  • Interactions between sympathomimetic amines and antidepressant agents in man. (webmd.com)
  • 3. To investigate the adverse effects of paroxetine in comparison with other anti-depressive agents. (cochrane.org)
  • Beckmann H, Kasper S. [Serotonin precursors as antidepressive agents: a review]. (unboundmedicine.com)
  • TY - JOUR T1 - [Serotonin precursors as antidepressive agents: a review]. (unboundmedicine.com)
  • A serotonin uptake inhibitor that is used as an antidepressive agent. (bioportfolio.com)
  • Fluoxetine hydrochloride is the first agent of the class of antidepressants known as selective serotonin-reuptake inhibitors (SSRIs). (drugbank.ca)
  • In this paper we review the literature on the influence of several agents on osseointegration, specifically, cyclosporine, glucocorticoids, alcohol, selective serotonin reuptake inhibitors, non-steroidal anti-inflammatory drugs, bisphosphonates and chemotherapeutic agents. (jcda.ca)
  • Contribution of electrophysiology to the study of tianeptine and other antidepressive agents]. (semanticscholar.org)
  • A Systematic Review of the Effectiveness of Antianxiety and Antidepressive Agents for Functional Dyspepsia. (physiciansweekly.com)
  • Therefore, psychotropic agents having antianxiety or antidepressive action are expected to alleviate FD. (physiciansweekly.com)
  • Methods Articles were searched for in MEDLINE from 2003 to 2014 using terms related to antianxiety or antidepressive agents. (physiciansweekly.com)
  • Psychotropic agents, such as mood stabilising drugs, antidepressants and antianxiety drugs, have been in widespread use since mid-1950s. (bmj.com)
  • Additionally, the use of antidepressive agents can interfere with blood pressure control of patients with hypertension by inducing changes in blood pressure and orthostatic hypotension. (scielo.br)
  • Ovid Embase 1980 - 2008 Week 23 (exp Antidepressive Agents, Tricyclic/ OR tricyclic.mp. (bestbets.org)
  • 2. To review acceptability of treatment with paroxetine in comparison with other anti-depressive agents. (cochrane.org)
  • St. John's wort (Hypericum perforatum) [online document], http://cam-cancer.org/en/st-johns-wort . (cam-cancer.org)
  • PubMed indexes 4,750 papers related to clinical trials of anti-depressive agents. (aafp.org)
  • Controlled studies indicate that short-term antidepressive medications or psychotherapy produce full remission in only about 46% of patients. (clinicaltrials.gov)
  • Skin reactions due to amitriptyline (a tricyclic antidepressant agent) include rashes and hypersensitivity reactions (for example, urticaria and photosensitivity) as well as hyperpigmentation. (bmj.com)
  • 1 Amitriptyline is a tricyclic antidepressant agent prescribed for the management of depressive illness, particularly when sedation is required. (bmj.com)
  • The interventions are targeted to the pathophysiology of disease, and regardless of the effect size of treatment, the outcomes will offer major scientific advances regarding the neurobiological action of these agents. (biomedcentral.com)
  • Antidepressive and neuroleptic agents, although not reported to be effective, have a limited use in patients who have adequate nutrition and mood changes associated with anorexia nervosa. (medscape.com)
  • We previously reported on the treatment of FD using such agents in a systematic review, wherein the effectiveness of the agents on FD was suggested, although there were several limitations. (physiciansweekly.com)
  • Development of HAM-D values during antidepressive treatment depending on the rs10868223 (A), rs1659412 (B) and rs11140778 (C) genotype (combined sample).Repeated measurements (Greenhouse-Geisser, age and sex as covariates) revealed significant interaction effects for rs10868223 (P = .007) and rs1659412 (P = .012), but not for rs11140778 (P = .645). (nih.gov)
  • In moxifloxacin-treated patients, dysglycemia occurred predominantly in elderly diabetic patients receiving concomitant treatment with an oral hypoglycemic agent (e.g. sulfonylurea) or with insulin. (medicines.ie)
  • Cholinergic agents and intravesically administered prostaglandin might possibly be beneficial in the treatment of post-operative urinary retention, although the evidence is insufficient. (essentialevidenceplus.com)
  • Inhaled corticosteroids are known to increase the risk of developing pneumonia in patients with chronic obstructive pulmonary disease (COPD), but it is unclear whether this risk varies for different agents, particularly fluticasone and budesonide. (bmj.com)
  • WHO HQ Library catalog › Results of search for 'su:{Antidepressive agents. (who.int)
  • Google search [{exp Antidepressive Agents, Tricyclic/ or tricyclic.mp} OR {clomipramine.mp. (bestbets.org)
  • Today it is mainly used as an anti-depressive agent, and there is good evidence that it is effective for that purpose 7 . (cam-cancer.org)
  • BACKGROUND: Mirtazapine has a unique mechanism of antidepressive action and is one of the commonly used antidepressants in clinical practice. (ox.ac.uk)
  • Clinical studies in which the effectiveness of such agents was clearly stated were selected from the retrieved articles. (physiciansweekly.com)
  • 11,12 Furthermore, several studies have reported that this agent may increase the incidence of bone fracture and may be associated with bone mineral loss. (jcda.ca)
  • 4-6 This category of agents inhibits 5-HT reuptake and exhibits very little of the unwanted results of the aforementioned agents that also block NE and/or DA. (clevelandclinicmeded.com)