Antibodies, Anticardiolipin: Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.Cardiolipins: Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.Lupus Coagulation Inhibitor: An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.Antiphospholipid Syndrome: The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).beta 2-Glycoprotein I: A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.Antibodies, Antiphospholipid: Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Abortion, Habitual: Three or more consecutive spontaneous abortions.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Blood Coagulation Factors: Endogenous substances, usually proteins, that are involved in the blood coagulation process.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Thrombophilia: A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Immunoglobulin Isotypes: The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Blood Coagulation Tests: Laboratory tests for evaluating the individual's clotting mechanism.Prothrombin: A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.Lupus Vasculitis, Central Nervous System: Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.Partial Thromboplastin Time: The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.Protein S Deficiency: An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)Pregnancy Complications, Hematologic: The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.Activated Protein C Resistance: A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Calciphylaxis: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Abortion, Spontaneous: Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Pregnancy Complications: Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.Venous Thrombosis: The formation or presence of a blood clot (THROMBUS) within a vein.Protein C: A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Anticoagulants: Agents that prevent clotting.Fetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Epitopes: Sites on an antigen that interact with specific antibodies.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Immunoglobulin Idiotypes: Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.Binding Sites, Antibody: Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).Mice, Inbred BALB CHIV Antibodies: Antibodies reactive with HIV ANTIGENS.Immunization, Passive: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Antibodies, Neoplasm: Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.Antibodies, Protozoan: Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.
Anticardiolipin antibodies[edit]. Anti-cardiolipin antibodies can be detected using an enzyme-linked immunosorbent assay (ELISA ... since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a ... Antiphospholipid syndrome is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and ... Patients with both Lupus anticoagulant antibodies and moderate/high titre anticardiolipin antibodies show a greater risk of ...
"HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with ... "HLA class II alleles associations of anticardiolipin antibodies". Lupus. 9 (1): 47-55. doi:10.1177/096120330000900109. PMID ... SLE associated anti-cardiolipin and anti-β2 glycoprotein I DRB1*04:03: polycystic ovary syndrome, SLE associated anti- ...
Takayasu arteritis is not associated with ANCA, rheumatoid factor, ANA, and anticardiolipin antibodies. Most people with ...
... anticardiolipin antibodies, thrombophilia, and hypofibrinolysis". J Lab Clin Med. 127 (5): 481-8. doi:10.1016/S0022-2143(96) ...
Anti-cardiolipin antibodies are found in both infectious (syphilis) and autoimmune disease (sclerosis, lupus). The activity of ... Shi W, Chong BH, Hogg PJ, Chesterman CN (1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of ... Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... anti-cardiolipin antibodies in autoimmune antiphospholipid syndrome requires apolipoprotein H. The subset of antibodies that ...
The syphilis anti-cardiolipin antibodies are beta-2 glycoprotein independent, whereas those that occur in the antiphospholipid ... Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... It therefore detects anti-cardiolipin antibodies (IgG, IgM or IgA), visualized through foaming of the test tube fluid, or " ... "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but ...
These antibodies are usually picked up in young women with recurrent spontaneous abortions. In anti-cardiolipin-mediated ... Patients with anti-cardiolipin antibodies (Antiphospholipid syndrome) can have recurrent thrombotic events even early in their ... Hokama Y, Campora CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K. Anticardiolipin antibodies in the sera of patients with ... Anti-cardiolipin antibodies can also be increased in numerous other conditions, including systemic lupus erythematosus, malaria ...
Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis.[ ... These antibodies clump into antibody-protein complexes which stick to surfaces and damage blood vessels in critical areas of ... Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE ... and anti-histone antibodies (which are linked to drug-induced lupus). Anti-dsDNA antibodies are highly specific for SLE; they ...
The two antibodies implicated are anticardiolipin and lupus anticoagulant. Anticardiolipin antibodies attach to the endothelial ... Anti-neuronal antibodies. The three identified anti-neuronal antibodies postulated in CNS involvement are the lympho-cytotoxic ... These antibodies also correlate with cognitive and visual spatial defects. Second, the anti-neuronal membrane antibodies are ... These antibodies are seen in 90% of SLE patients with psychosis. Antiphospholipid antibodies. ...
... headaches in SLE and associated Raynaud's phenomenon and/or anti-cardiolipin antibodies. Further studies are needed however to ... Annese V, Tomietto P, Venturini P, D'Agostini S, Ferraccioli G (2006). "[Migraine in SLE: role of antiphospholipid antibodies ...
2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ... acute necrotizing encephalopathy DRB3*0301 is weakly associated with anti-cardiolipin antibodies in SLE DRB3*0301:DRB1*1302 may ... "Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly ... serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, ...
... anti-cardiolipin antibodies, is indicated. Screening for protein C, protein S, or antithrombin III deficiency is sometimes ...
"Identification of a region of β2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity" ( ... "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but ... and a region recognized by anticardiolipin antibodies" (1994) Journal of Immunology, 152 (2), pp. 653-659. Cited 195 times. ... McNeil, H.P., Chesterman, C.N., Krilis, S.A. "Immunology and clinical importance of antiphospholipid antibodies" (1991) ...
Aortic dissection Anti-cardiolipin antibodies CMV infection Herpetic infection Hyperglycemia Hypersensitivity to broad-spectrum ...
... is an acronym that may refer to: Anti-cardiolipin antibodies Allegheny County Library Association, a library association ...
... acid Advisory Committee for Aeronautics Anterior cerebral artery Anti-cardiolipin antibodies Anti-centromere antibodies ...
... the other component being the serological testing for anticardiolipin antibodies and anti-β2 glycoprotein-I antibodies using ... Antiphospholipid antibody syndrome is an important marker for recurrent thrombosis, and often warrants indefinite anticoagulant ... because these antibodies interfere with the clot-promoting role of phospholipid in vitro, and their presence results in a ... a ratio of greater than 1.3 is considered a positive result and implies that the patient may have antiphospholipid antibodies. ...
... and anticardiolipin antibodies. Neonatal lupus is the occurrence of SLE symptoms in an infant born from a mother with SLE, most ... Women pregnant and known to have anti-Ro (SSA) or anti-La antibodies (SSB) often have echocardiograms during the 16th and 30th ... are recommended to be screened for antiphospholipid antibodies, both the lupus anticoagulant (the RVVT and sensitive PTT are ...
... also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These ... Shi W, Chong BH, Hogg PJ, Chesterman CN (1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of ... This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies that specifically ... 2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ...
They are a form of anti-mitochondrial antibody. In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present ... Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including ... Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with ... because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. Anti- ...
Anti-cardiolipin antibodies are another type of AMA, and cardiolipin is found on the inner mitochondrial membrane. A cause of ... had anti-transglutaminase antibodies, usually associated with coeliac disease. Antibodies Mitochondrion MedlinePlus ... and non-species-specific anti-organelle antibody detected by immunofluorescence: the mitochondrial antibody number 5. Clin Exp ... Antimitochondrial antibodies can also be detected in Sjögren's syndrome, systemic sclerosis, asymptomatic recurrent bacteriuria ...
抗心磷脂(英語:Anti-cardiolipin antibodies). 抗細胞質抗體. *抗中性白血球細胞質抗體/ANCA(英語:Anti-neutrophil cytoplasmic antibody) *C-ANCA(英語:C-ANCA) ... 抗體(antibody),又稱免疫球蛋白(immunoglobulin,簡稱Ig)[1],是一種主要由漿細胞分泌,被免疫系統用來鑑別與中和外來物質如細菌、病毒等病原體的大型Y形蛋
Anti-mitochondrial antibody. *Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA ... Antibody mimetic[edit]. Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens. They are ... Asymmetrical antibodies[edit]. Heterodimeric antibodies, which are also asymmetrical and antibodies, allow for greater ... How Lymphocytes Produce Antibody from Cells Alive!. *Antibody applications Fluorescent antibody image library, University of ...
... antibodies, antiphospholipid MeSH D12.776.377.715.548.114.323.210.100 - antibodies, anticardiolipin MeSH D12.776.377.715. ... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... antibodies, bispecific MeSH D12.776.377.715.548.114.143 - antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, ... antibodies, helminth MeSH D12.776.377.715.548.114.191 - antibodies, heterophile MeSH D12.776.377.715.548.114.224 - antibodies, ...
... antibodies, antiphospholipid MeSH D12.776.124.486.485.114.323.210.100 -- antibodies, anticardiolipin MeSH D12.776.124.486. ... antibodies, antiphospholipid MeSH D12.776.124.790.651.114.323.210.100 -- antibodies, anticardiolipin MeSH D12.776.124.790. ... antibodies MeSH D12.776.124.486.485.114.071 -- antibodies, anti-idiotypic MeSH D12.776.124.486.485.114.089 -- antibodies, ... antibodies, blocking MeSH D12.776.124.486.485.114.167 -- antibodies, catalytic MeSH D12.776.124.486.485.114.179 -- antibodies, ...
... is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common in women than in men. The exact cause is not known, but activation of the system of coagulation is evident. Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease state) forms. Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by ...
... (also known as lupus antibody, LA, LAC, or lupus inhibitors) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Lupus anticoagulant is a misnomer, as it is actually a prothrombotic agent. Lupus anticoagulant antibodies in living systems cause an increase in inappropriate blood clotting. The name derives from their properties in vitro, since in laboratory tests, these antibodies increase aPTT. Investigators speculate that the antibodies interfere with phospholipids used to induce in vitro coagulation. In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of platelets, which accounts for the in vivo prothrombotic characteristics. The condition was first described by hematologist C. Lockard Conley. Both words in the term "lupus anticoagulant" can be misleading: ...
... (millimeter) is the film gauge most commonly used for motion pictures and chemical still photography (see 135 film). The name of the gauge refers to the width of the photographic film, which consists of strips 34.98 ±0.03 mm (1.377 ±0.001 inches) wide. The standard negative pulldown for movies ("single-frame" format) is four perforations per frame along both edges, which results in 16 frames per foot of film. For still photography, the standard frame has eight perforations on each side. A variety of largely proprietary gauges were devised for the numerous camera and projection systems being developed independently in the late 19th century and early 20th century, ranging from 13 mm to 75 mm (0.51-2.95 in), as well as a variety of film feeding systems. This resulted in cameras, projectors, and other equipment having to be calibrated to each gauge. The 35 mm width, originally specified as 1.375 inches, was introduced in 1892 by William Dickson and Thomas Edison, using 120 film stock ...
... is a protein that in humans is encoded by the TAZ gene. Tafazzin is highly expressed in cardiac and skeletal muscle. It is involved in the metabolism of cardiolipin. Tafazzin functions as a phospholipid-lysophospholipid transacylase. The mutation of the tafazzin gene is associated with a number of clinical disorders including Barth syndrome (BTHS) (type II 3-Methylglutaconic aciduria), dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Tafazzin is responsible for remodeling of a phospholipid cardiolipin (CL), the signature lipid of the mitochondrial inner membrane. As a result, BTHS patients exhibit defects in CL metabolism, including aberrant CL fatty acyl composition, accumulation of monolysocardiolipin (MLCL) and reduced total CL levels. The protein was identified by Italian scientists Silvia Bione et al. in 1996. Owing to the complex procedure required for the identification of tafazzin, the protein was named after ...
... is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common in women than in men. The exact cause is not known, but activation of the system of coagulation is evident. Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease state) forms. Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by ...
... (also known as lupus antibody, LA, LAC, or lupus inhibitors) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Lupus anticoagulant is a misnomer, as it is actually a prothrombotic agent. Lupus anticoagulant antibodies in living systems cause an increase in inappropriate blood clotting. The name derives from their properties in vitro, since in laboratory tests, these antibodies increase aPTT. Investigators speculate that the antibodies interfere with phospholipids used to induce in vitro coagulation. In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of platelets, which accounts for the in vivo prothrombotic characteristics. The condition was first described by hematologist C. Lockard Conley. Both words in the term "lupus anticoagulant" can be misleading: ...
... also has an intermediate role in apoptosis, a controlled form of cell death used to kill cells in the process of development or in response to infection or DNA damage.[20]. Cytochrome c binds to cardiolipin in the inner mitochondrial membrane, thus anchoring its presence and keeping it from releasing out of the mitochondria and initiating apoptosis. While the initial attraction between cardiolipin and cytochrome c is electrostatic due to the extreme positive charge on cytochrome c, the final interaction is hydrophobic, where a hydrophobic tail from cardiolipin inserts itself into the hydrophobic portion of cytochrome c.. During the early phase of apoptosis, mitochondrial ROS production is stimulated, and cardiolipin is oxidized by a peroxidase function of the cardiolipin-cytochrome c complex. The hemoprotein is then detached from the mitochondrial inner membrane and can be extruded into the soluble cytoplasm through pores in the outer membrane.[21]. The sustained elevation in ...
... (also known as lupus antibody, LA, LAC, or lupus inhibitors) is an immunoglobulin that binds to phospholipids and proteins associated with the cell membrane. Lupus anticoagulant is a misnomer, as it is actually a prothrombotic agent. Lupus anticoagulant antibodies in living systems cause an increase in inappropriate blood clotting. The name derives from their properties in vitro, since in laboratory tests, these antibodies increase aPTT. Investigators speculate that the antibodies interfere with phospholipids used to induce in vitro coagulation. In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of platelets, which accounts for the in vivo prothrombotic characteristics. The condition was first described by hematologist C. Lockard Conley. Both words in the term "lupus anticoagulant" can be misleading: ...
... is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common in women than in men. The exact cause is not known, but activation of the system of coagulation is evident. Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease state) forms. Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by ...
Mixing studies are tests performed on blood plasma used to distinguish factor deficiencies from factor inhibitors, such as lupus anticoagulant, or specific factor inhibitors, such as antibodies directed against factor VIII. Mixing studies take advantage of the fact that factor levels that are 50 percent of normal should give a normal Prothrombin time (PT) or Partial thromboplastin time (PTT) result. If the problem is a simple factor deficiency, mixing the patient plasma 1:1 with plasma that contains 100% of the normal factor level results in a level ≥50% in the mixture (say the patient has an activity of 0%; the average of 100% + 0% = 50%). The PT or PTT will be normal (the mixing study shows correction). Correction with mixing indicates factor deficiency; failure to correct indicates an inhibitor. Performing a thrombin time on the test plasma can provide useful additional information for the interpretation of mixing tests. Some inhibitors are time dependent. In other words, ...
... is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common in women than in men. The exact cause is not known, but activation of the system of coagulation is evident. Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease state) forms. Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by ...
... (RVT) is the formation of a clot in the vein that drains blood from the kidneys, ultimately leading to a reduction in the drainage of one or both kidneys and the possible migration of the clot to other parts of the body. First described by German pathologist Friedrich Daniel von Recklinghausen in 1861, RVT most commonly affects two subpopulations: newly born infants with blood clotting abnormalities or dehydration and adults with nephrotic syndrome. Nephrotic syndrome, a kidney disorder, causes excessive loss of protein in the urine, hypoalbuminemia, hypercholesterolemia and edema, triggering a hypercoagulable state and increasing chances of clot formation. Other less common causes include hypercoagulable state, cancer, renal transplantation, behcet syndrome, antiphospholipid antibody syndrome or blunt trauma to the back or abdomen. Treatment of RVT mainly focuses on preventing further blood clots in the kidneys and maintaining stable renal function. The use of ...
Медаль Хьюза (англ. Hughes Medal) - награда Лондонского королевского общества, присуждаемая «за оригинальные открытия в области физических наук, особенно связанных с производством, хранением и использованием энергии». Учреждена в честь изобретателя Дэвида Хьюза[1]. С 2011 года вручается раз в два года. Впервые медаль была вручена в 1902 году, её получил Джозеф Томсон «за большой вклад в науку об электричестве». С тех пор она вручалась ежегодно, лишь в 1924 и 2009 годах по неизвестной причине никто не был удостоен медали. В отличие от других наград Лондонского ...
They are a form of anti-mitochondrial antibody. In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present ... Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including ... Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with ... because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. Anti- ...
Anticardiolipin antibodies are the result of an autoimmune disorder where your body makes antibodies against its own tissues. ... Anticardiolipin Antibodies Tracey__0 I am a 25 year old woman. I consider myself to be physically and mentally fit, I guess ... Whether you are at risk of death from this disorder is hard to determine, but most patients with anticardiolipin antibodies are ... these chemicals cannot prevent clots from developing in the placental blood vessels from the anticardiolipin antibodies. These ...
A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute ... On lab workup, it was found that she was "positive (for) anticardiolipin IgM and anticardiolipin IgG phospholipid antibodies". ... Anticardiolipin antibodies and COVID-19. News-Medical. https://www.news-medical.net/news/20200610/Anticardiolipin-antibodies- ... A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute ...
... an antibody that is directed against phospholipids and especially cardiolipin and is associated with increased risk for ... recurring arterial and venous thromboses -called also anticardiolipin. ... Share anticardiolipin antibody. Post the Definition of anticardiolipin antibody to Facebook Share the Definition of anticardio ... Comments on anticardiolipin antibody. What made you want to look up anticardiolipin antibody? Please tell us where you read or ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ... Anti-Cardiolipin Antibodies, IgG & IgM. 2. Anti-Cardiolipin Antibody, IgG. 3. Adenovirus Antibody, IgG. 4. Adenovirus Antibody ... Anti-dsDNA Antibody, IgG. 7. Anti-GBM Antibody, IgA (IFA). 8. Anti-GBM Antibody, IgG (IFA). 9. Anti-GBM Antibody, IgG (ELISA). ... Anti-Glomerular Basement Membrane Antibody, IgA (IFA). 11. Anti-Glomerular Basement Membrane Antibody, IgG (ELISA). ...
... antibody is important in diagnosing antiphospholipid syndrome (APS). According to the Second International Anti-cardiolipin ... encoded search term (Anticardiolipin Antibody) and Anticardiolipin Antibody What to Read Next on Medscape. Related Conditions ... Anticardiolipin (aCL) antibody of immunoglobulin G (IgG) and/or immunoglobulin M (IgM) isotype present in serum (,40 GPL or MPL ... Consensus guidelines on anti-cardiolipin antibody testing and reporting. Pathology. 2004 Feb. 36(1):63-8. [Medline]. ...
This time the lupus anticoagulant came back negative, but this time the anticardiolipin antibodies came back pos. Doc says to ... HealingWell.com Forum , Diseases & Conditions , Lupus , anticardiolipin antibodies Select A Location. ****** Top of the Forum ... These together can help greatly with some lesser symptoms such as brain fog when it is due to these antibodies.. I would be far ... Either the anticardiolipin tests or the lupus anticoagulant can be positive at any time or negative. Thats why both tests are ...
Degos disease: association with anticardiolipin antibodies and the lupus anticoagulant. Br Med J (Clin Res Ed) 1984; 289 :576 ... Degos disease: association with anticardiolipin antibodies and the lupus anticoagulant.. Br Med J (Clin Res Ed) 1984; 289 doi ...
A high level of anticardiolipin antibody activity was detected among 19.23% of the habitual aborters but in none of the ... Daboubi, M.K. (‎2001)‎. Anticardiolipin antibodies in women with recurrent abortion. EMHJ - Eastern Mediterranean Health ... Enzyme-linked immunosorbent assay was used for detection of anticardiolipin antibodies in a group of 26 patients defined as ... The present study sought to determine whether the level of anticardiolipin antibodies in women with recurrent abortion differed ...
Anticardiolipin Antibodies and Hypercoagulability Matthew H. Liang, MD; Charles H. Hennekens, MD; Meir J. Stampfer, MD ... Anticardiolipin Antibodies and Hypercoagulability. Ann Intern Med. 1993;118:986-987. doi: 10.7326/0003-4819-118-12-199306150- ... Hess lists several potential reasons why we were not able to detect an association between anticardiolipin antibodies and risk ... Although an association between anticardiolipin antibodies and ischemic stroke cannot be ruled out, as we noted in our paper, ...
Livedoid vasculitis with anticardiolipin antibodies: improvement with danazol. Authors. *. Wakelin,. * St Johns Institute of ...
Idiopathic intracranial hypertension and anticardiolipin antibodies Message subject: (Your Name) has forwarded a page to you ...
Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia Cesare Masala, MD; Maurizio Sorice, MD; Maria A. Di Prima, MD; ... To the Editor: Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with ... We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among ... Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia. Ann Intern Med. 1989;110:749. doi: https://doi.org/10.7326/0003- ...
Thirty (21%) had raised anticardiolipin antibody levels compared with only three in 98 age matched controls. The highest ... The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. ... while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. This ...
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Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease. TJ Hendra, EN Harris, RC Trembath, GRV Hughes, JS ... Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease. TJ Hendra, EN Harris, RC Trembath, GRV Hughes, JS ... Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease Message Subject (Your Name) has forwarded a page to ...
... and anticardiolipin antibodies (ACA) and their relationship to each other in a healthy population of 499 blood donors. Plasma ... Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population Aust N Z J Med. 1990 Jun;20(3):231-6. ... This study was designed to explore the incidence of lupus anticoagulant (LA) and anticardiolipin antibodies (ACA) and their ... Neither ACA nor LA were associated with antinuclear antibodies (ANA) or rheumatoid factor (Rh factor). Thus, in a healthy ...
... in the presence of anticardiolipin antibodies). The suppression of lymphocyte proliferation by anticardiolipin antibodies was ... Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles ... These newly found activities of anticardiolipin antibodies were mediated by the non-specific membranotropic property of the ... These results suggest that anticardiolipin antibodies exert inhibitory effects on both lymphocytes and phagocytes in addition ...
IgM anticardiolipin antibodies in human serum or plasma. Order the test online through Personalabs today! ... Anticardiolipin antibodies, IgA, quantitative - TC - 7352. Anticardiolipin antibodies, IgG, quantitative. Anticardiolipin ... Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome. Individuals with the ... This test measures the level of IgA, IgG, IgM anticardiolipin antibodies in human serum or plasma. Order the test online ...
To investigate anticardiolipin antibodies (aCL), anti-beta2-glycoprotein I (anti-beta2GPI), and antinucleosome antibodies in ... Anticardiolipin, anti-beta2-glycoprotein I, and Antinucleosome Antibodies in Hepatitis C Virus Infection and Mixed ... Anti-HCV antibodies were detected by 3rd generation tests, aCL, anti-beta2GPI, and antinucleosorne antibodies were detected by ... Antibodies directed to beta2GPI, a co-factor of aCL, have been said to be associated with the presence of "autoimmune" aCL. ...
Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase ... Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase ... Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly ... Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL ...
Antiphospholipid Antibodies in Stroke Study (APASS) group. Anticardiolipin antibodies are an independent risk factor for first ... Matsuura E. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol. 1992;148:3885-3891. ... Antiphospholipid Antibodies in Stroke Study (APASS) group. Anticardiolipin antibodies and the risk of recurrent thrombo- ... Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome and with ...
It is a Custom assay which can detect Anti-Cardiolipin antibody (IgM) down to 0.375 Nanograms per millilter. ... Anti-Cardiolipin antibody (IgM) ELISA Kit LS-F41209 is a 96-Well enzyme-linked immunosorbent assay for the Quantitative ... Popular Anti-Cardiolipin antibody (IgM) Elisa Kits. Human Anti-Cardiolipin antibody (IgM) ELISA Kit (Indirect ELISA) - LS- ... Guinea pig Anti-Cardiolipin antibody (IgM) ELISA Kit (Custom ELISA) - LS-F41208 ...
... ELISA method for quantitative determination of Anti-Cardiolipin / Anti ... Rat Antibodies Rat Cytokines Rat ELISA Antibody Pairs Rat ELISA KIts Rat ELISPOT Kits Rat ELISPOT Antibody Pairs ... Human Antibody Human Cytokine Flurospot Kit Human ELISA Antibody pair Human ELISA Kits Human ELISPOT Antibody pairs Human ... Monkey Antibodies Monkey ELISA Antibody Pair Monkey ELISA kit Monkey ELISPOT Antibody Pair Monkey ELISPOT Kit Monkey Cytokine ...
Publications] T.Koike.: Anticardiolipin antibodies and β_2-glycoprotein I. Clin Immunol Immunopathol. 72. 187-192 (1994). *. ... Publications] T.Koike.: Anticardiolipin antibodies and β2-glycoprotein I. Clin Immunol Immunopathol.72. 187-192 (1994). *. ... Publications] T.Koike: Anticardiolipin antibodies and beta2-glycoprotein I. Clin Immunol Immunopathol. 72. 187-192 (1994). * ... Publications] Y.Kita,T.Sumida,I.Iwamoto,Y.Yoshida,T.Koike: V gene analysis of anti-cardiolipin antibodies from (NZW x BXSB) Fl ...
  • The patient on initial screening will typically have been found to have a prolonged APTT that does not correct in an 80:20 mixture with normal human plasma (50:50 mixes with normal plasma are insensitive to all but the highest antibody levels). (thefullwiki.org)
  • In order to improve APS diagnosis, several new approaches in aPL detection have recently been suggested, such as multiline immunodot assay, detection of aPL by flow cytometry using beads with particular surface properties, and the newly developed automated BioPlex system technology for parallel detection of aCL and anti-β2GPI antibodies of IgG, IgA, and IgM isotypes. (intechopen.com)