Anticarcinogenic Agents: Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.Antimutagenic Agents: Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.Trypsin Inhibitor, Bowman-Birk Soybean: A low-molecular-weight protein (minimum molecular weight 8000) which has the ability to inhibit trypsin as well as chymotrypsin at independent binding sites. It is characterized by a high cystine content and the absence of glycine.Isothiocyanates: Organic compounds with the general formula R-NCS.Butylated Hydroxyanisole: Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.9,10-Dimethyl-1,2-benzanthracene: 7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.Garlic: One of the Liliaceae used as a spice (SPICES) and traditional remedy. It contains alliin lyase and alliin, which is converted by alliin lyase to allicin, the pungent ingredient responsible for the aroma of fresh cut garlic.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Croton Oil: Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.Silymarin: A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.Panax: An araliaceous genus of plants that contains a number of pharmacologically active agents used as stimulants, sedatives, and tonics, especially in traditional medicine. Sometimes confused with Siberian ginseng (ELEUTHEROCOCCUS).Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.Butylated Hydroxytoluene: A di-tert-butyl PHENOL with antioxidant properties.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Benz(a)Anthracenes: Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.Momordica charantia: A plant species of the family CUCURBITACEAE. It is a source of ribosome-inactivating proteins and triterpene glycosides.Ellagic Acid: A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.Tea: The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.NAD(P)H Dehydrogenase (Quinone): A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.Norisoprenoids: Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.Allyl CompoundsThiocyanates: Organic derivatives of thiocyanic acid which contain the general formula R-SCN.Anisoles: A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.Perilla frutescens: A plant genus of the family LAMIACEAE that is an ingredient of Banxia Houpu (DRUGS, CHINESE HERBAL).Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.Glutathione Transferase: A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.Diet: Regular course of eating and drinking adopted by a person or animal.Brassica: A plant genus of the family Cruciferae. It contains many species and cultivars used as food including cabbage, cauliflower, broccoli, Brussel sprouts, kale, collard greens, MUSTARD PLANT; (B. alba, B. junica, and B. nigra), turnips (BRASSICA NAPUS) and rapeseed (BRASSICA RAPA).Caffeic Acids: A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.Glucosinolates: Substituted thioglucosides. They are found in rapeseed (Brassica campestris) products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Chemoprevention: The use of chemical compounds to prevent the development of a specific disease.Trypsin Inhibitors: Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.Linoleic Acids, Conjugated: A collective term for a group of around nine geometric and positional isomers of LINOLEIC ACID in which the trans/cis double bonds are conjugated, where double bonds alternate with single bonds.Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.Colonic Neoplasms: Tumors or cancer of the COLON.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Terpenes: A class of compounds composed of repeating 5-carbon units of HEMITERPENES.Enzyme Induction: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.Flavonoids: A group of phenyl benzopyrans named for having structures like FLAVONES.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Isoflavones: 3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.Sulfides: Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Soybeans: An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Mammary Neoplasms, Experimental: Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.Quercetin: A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.Linoleic Acids: Eighteen-carbon essential fatty acids that contain two double bonds.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Polyphenols: A large class of organic compounds having more than one PHENOL group.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Vegetables: A food group comprised of EDIBLE PLANTS or their parts.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Cell Line, Tumor: A cell line derived from cultured tumor cells.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Cyclooxygenase 2: An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Fruit: The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.Rats, Inbred F344Carotenoids: The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Skin Neoplasms: Tumors or cancer of the SKIN.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Breast Neoplasms: Tumors or cancer of the human BREAST.Lung Neoplasms: Tumors or cancer of the LUNG.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.NF-kappa B: Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Isoenzymes: Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. (1/2345)

The epidemiologic literature in the English language regarding intake of tomatoes and tomato-based products and blood lycopene (a compound derived predominantly from tomatoes) level in relation to the risk of various cancers was reviewed. Among 72 studies identified, 57 reported inverse associations between tomato intake or blood lycopene level and the risk of cancer at a defined anatomic site; 35 of these inverse associations were statistically significant. No study indicated that higher tomato consumption or blood lycopene level statistically significantly increased the risk of cancer at any of the investigated sites. About half of the relative risks for comparisons of high with low intakes or levels for tomatoes or lycopene were approximately 0.6 or lower. The evidence for a benefit was strongest for cancers of the prostate, lung, and stomach. Data were also suggestive of a benefit for cancers of the pancreas, colon and rectum, esophagus, oral cavity, breast, and cervix. Because the data are from observational studies, a cause-effect relationship cannot be established definitively. However, the consistency of the results across numerous studies in diverse populations, for case-control and prospective studies, and for dietary-based and blood-based investigations argues against bias or confounding as the explanation for these findings. Lycopene may account for or contribute to these benefits, but this possibility is not yet proven and requires further study. Numerous other potentially beneficial compounds are present in tomatoes, and, conceivably, complex interactions among multiple components may contribute to the anticancer properties of tomatoes. The consistently lower risk of cancer for a variety of anatomic sites that is associated with higher consumption of tomatoes and tomato-based products adds further support for current dietary recommendations to increase fruit and vegetable consumption.  (+info)

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. (2/2345)

BACKGROUND: Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of foods contaminated with aflatoxins, which require metabolic activation to become carcinogenic. In a randomized, placebo-controlled, double-blind phase IIa chemoprevention trial, we tested oltipraz, an antischistosomal drug that has been shown to be a potent and effective inhibitor of aflatoxin-induced hepatocarcinogenesis in animal models. METHODS: In 1995, 234 adults from Qidong were enrolled. Healthy eligible individuals were randomly assigned to receive by mouth 125 mg oltipraz daily, 500 mg oltipraz weekly, or a placebo. Sequential immunoaffinity chromatography and liquid chromatography coupled to mass spectrometry or to fluorescence detection were used to identify and quantify phase 1 and phase 2 metabolites of aflatoxin B1 in the urine of study participants. Reported P values are two-sided. RESULTS: One month of weekly administration of 500 mg oltipraz led to a 51% decrease in median levels of the phase 1 metabolite aflatoxin M1 excreted in urine compared with administration of a placebo (P = .030), but it had no effect on levels of a phase 2 metabolite, aflatoxin-mercapturic acid (P = .871). By contrast, daily intervention with 125 mg oltipraz led to a 2.6-fold increase in median aflatoxin-mercapturic acid excretion (P = .017) but had no effect on excreted aflatoxin M1 levels (P = .682). CONCLUSIONS: Intermittent, high-dose oltipraz inhibited phase 1 activation of aflatoxins, and sustained low-dose oltipraz increased phase 2 conjugation of aflatoxin, yielding higher levels of aflatoxin-mercapturic acid. While both mechanisms can contribute to protection, this study highlights the feasibility of inducing phase 2 enzymes as a chemopreventive strategy in humans.  (+info)

Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. (3/2345)

BACKGROUND: Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory effects on the growth and invasive properties of human mammary cancer cells in vitro; furthermore, the two agents have displayed additive effects in vitro. In this study, we examined whether tangeretin would enhance tamoxifen's therapeutic benefit in vivo. METHODS: Female nude mice (n = 80) were inoculated subcutaneously with human MCF-7/6 mammary adenocarcinoma cells. Groups of 20 mice were treated orally by adding the following substances to their drinking water: tamoxifen (3 x 10(-5) M), tangeretin (1 x 10(-4) M), tamoxifen plus tangeretin (3 x 10(-5) M plus 1 x 10(-4) M), or solvent. RESULTS AND CONCLUSIONS: Oral treatment of mice with tamoxifen resulted in a statistically significant inhibition of tumor growth compared with solvent treatment (two-sided P = .001). Treatment with tangeretin did not inhibit tumor growth, and addition of this compound to drinking water with tamoxifen completely neutralized tamoxifen's inhibitory effect. The median survival time of tumor-bearing mice treated with tamoxifen plus tangeretin was reduced in comparison with that of mice treated with tamoxifen alone (14 versus 56 weeks; two-sided P = .002). Tangeretin (1 x 10(-6) M or higher) inhibited the cytolytic effect of murine natural killer cells on MCF-7/6 cells in vitro, which may explain why tamoxifen-induced inhibition of tumor growth in mice is abolished when tangeretin is present in drinking water. IMPLICATIONS: We describe an in vivo model to study potential interference of dietary compounds, such as flavonoids, with tamoxifen, which could lead to reduced efficacy of adjuvant therapy. In our study, the tumor growth-inhibiting effect of oral tamoxifen was reversed upon addition of tangeretin to the diet. Our data argue against excessive consumption of tangeretin-added products and supplements by patients with mammary cancer during tamoxifen treatment.  (+info)

Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. (4/2345)

BACKGROUND: Retinoids (derivatives of vitamin A) are reported to reduce the occurrence of some second primary cancers, including aerodigestive tract tumors. In contrast, beta-carotene does not reduce the occurrence of primary aerodigestive tract cancers. Mechanisms explaining these effective retinoid and ineffective carotenoid chemoprevention results are poorly defined. Recently, the all-trans-retinoic acid (RA)-induced proteolysis of cyclin D1 that leads to the arrest of cells in G1 phase of the cell cycle was described in human bronchial epithelial cells and is a promising candidate for such a mechanism. In this study, we have investigated this proteolysis as a common signal used by carotenoids or receptor-selective and receptor-nonselective retinoids. METHODS: We treated cultured normal human bronchial epithelial cells, immortalized human bronchial epithelial cells (BEAS-2B), and transformed human bronchial epithelial cells (BEAS-2BNNK) with receptor-selective or receptor-nonselective retinoids or with carotenoids and studied the effects on cell proliferation by means of tritiated thymidine incorporation and on cyclin D1 expression by means of immunoblot analysis. We also examined whether calpain inhibitor I, an inhibitor of the 26S proteasome degradation pathway, affected the decline (i.e., proteolysis) of cyclin D1. RESULTS: Receptor-nonselective retinoids were superior to the carotenoids studied in mediating the decline in cyclin D1 expression and in suppressing the growth of bronchial epithelial cells. Retinoids that activated retinoic acid receptor beta or retinoid X receptor pathways preferentially led to a decrease in the amount of cyclin D1 protein and a corresponding decline in growth. The retinoid-mediated degradation of cyclin D1 was blocked by cotreatment with calpain inhibitor I. CONCLUSIONS: Retinoid-dependent cyclin D1 proteolysis is a common chemoprevention signal in normal and neoplastic human bronchial epithelial cells. In contrast, carotenoids did not affect cyclin D1 expression. Thus, the degradation of cyclin D1 is a candidate intermediate marker for effective retinoid-mediated cancer chemoprevention in the aerodigestive tract.  (+info)

Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy. (5/2345)

Full term pregnancy early in life is the most effective natural protection against breast cancer in women. Rats treated with chemical carcinogen are similarly protected by a previous pregnancy from mammary carcinogenesis. Proliferation and differentiation of the mammary gland does not explain this phenomenon, as shown by the relative ineffectiveness of perphenazine, a potent mitogenic and differentiating agent. Here, we show that short term treatment of nulliparous rats with pregnancy levels of estradiol 17beta and progesterone has high efficacy in protecting them from chemical carcinogen induced mammary cancers. Because the mammary gland is exposed to the highest physiological concentrations of estradiol and progesterone during full term pregnancy, it is these elevated levels of hormones that likely induce protection from mammary cancer. Thus, it appears possible to mimic the protective effects of pregnancy against breast cancer in nulliparous rats by short term specific hormonal intervention.  (+info)

Inhibition of aberrant proliferation and induction of apoptosis in HER-2/neu oncogene transformed human mammary epithelial cells by N-(4-hydroxyphenyl)retinamide. (6/2345)

Epithelial cells from non-cancerous mammary tissue in response to exposure to chemical carcinogens or transfection with oncogenes exhibit hyperproliferation and hyperplasia prior to the development of cancer. Aberrant proliferation may, therefore, represent a modifiable early occurring preneoplastic event that is susceptible to chemoprevention of carcinogenesis. The synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR), has exhibited preventive efficacy in several in vitro and in vivo breast cancer models, and represents a promising chemopreventive compound for clinical trials. Clinically relevant biochemical and cellular mechanisms responsible for the chemopreventive effects of HPR, however, are not fully understood. Experiments were performed on preneoplastic human mammary epithelial 184-B5/HER cells derived from reduction mammoplasty and initiated for tumorigenic transformation by overexpression of HER-2/neu oncogene, to examine whether HPR inhibits aberrant proliferation of these cells and to identify the possible mechanism(s) responsible for the inhibitory effects of HPR. Continuous 7-day treatment with HPR produced a dose-dependent, reversible growth inhibition. Long-term (21 day) treatment of 184-B5/HER cells with HPR inhibited anchorage-dependent colony formation by approximately 80% (P < 0.01) relative to that observed in the solvent control. A 24 h treatment with cytostatic 400 nM HPR produced a 25% increase (P = 0.01) in G0/G1 phase, and a 36% decrease (P = 0.01) in S phase of the cell cycle. HPR treatment also induced a 10-fold increase (P = 0.02) in the sub-G0 (apoptotic) peak that was down-regulated in the presence of the antioxidant N-acetyl-L-cysteine. Treatment with HPR resulted in a 30% reduction of cellular immunoreactivity to tyrosine kinase, whereas immunoreactivity to p185HER remained essentially unaltered. HPR exposure resulted in time-dependent increase in cellular metabolism of the retinoid as evidenced by increased formation of the inert metabolite N-(4-methoxyphenyl)-retinamide (MPR) and progressive increase in apoptosis. Thus, HPR-induced inhibition of aberrant proliferation may be caused, in part, by its ability to inhibit HER-2/neu-mediated proliferative signal transduction, retard cell cycle progression and upregulate cellular apoptosis.  (+info)

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. (7/2345)

Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for the prevention of cancer. However, the mechanism of the anti-carcinogenic activity of resveratrol is not well understood. Here we offer a possible explanation of its anti-cancer effect. Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis.  (+info)

Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (8/2345)

We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis.  (+info)

*Etomoxir

The University of Colorado currently holds patents for the use of etomoxir as an anti-inflammatory and anticarcinogenic agent. ... Etomoxir and a 2-deoxy-D-glucose Compound; Antiinflammatory, Antiproliferative, Anticarcinogenic and Wound Healing Agents; Drug ...

*Terminalia catappa

The leaves may contain agents for prevention of cancers (although they have no demonstrated anticarcinogenic properties) and ...

*List of MeSH codes (D16)

... anticarcinogenic agents MeSH D27.505.954.248.144 --- antimetabolites, antineoplastic MeSH D27.505.954.248.147 --- antimitotic ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ...

*Semicarbazide-cadmium therapy

As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. Hydrazine sulfate ... It can also be anti-carcinogenic under certain conditions. At low concentrations, cadmium is able to stimulate the immune ...

*Myricetin

It has also been shown that myricetin can itself act as an agent of mutagenicity. Myricetin can produce frameshift mutations in ... Clearly there is a multifaceted, complex system involved in the anticarcinogenic activity displayed by myricetin that does not ... Basli A, Soulet S, Chaher N, Merillon JM, Chibane M, Monti JP, Richard T (July 2012). "Wine polyphenols: potential agents in ... Myricetin's pro-oxidative capabilities can also be seen in its ability to act as an inhibitory agent against glutathione ...

*Dacemazine

David J. Triggle; C. R. Ganellin; F. MacDonald (1996). Dictionary of Pharmacological Agents. 1. Boca Raton: Chapman & Hall/CRC ... Karolyhazy G, Havas I, Jansco G, Kapas L, Sellei C. The anticarcinogenic effect of dimethylaminoacetyl-phentiazide (ahistan). ...

*Index of oncology articles

... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... anticarcinogenic - anticoagulant - anticonvulsant - antidepressant - antiemetic - antiestrogen - antifolate - antifungal ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ... adjunct agent - adjunctive therapy - adjuvant therapy - adrenocortical - Adriamycin - adult T-cell leukemia/lymphoma - AE-941 ...

*List of vegetable oils

Used as a drying agent in paints and varnishes. Tung oil, used as an industrial lubricant and highly effective drying agent. ... Of current research interest for its potential anti-carcinogenic properties. Bottle gourd oil, extracted from the seeds of the ... Dammar oil, from the Canarium strictum, used in paint as an oil drying agent. Can also be used as a lamp oil. Linseed oil's ... Used as a flavoring agent and in aromatherapy. Orange oil, like lemon oil, cold pressed rather than distilled. Consists of 90% ...

*Microsporum nanum

Griseofulvin, clotrimazole and miconazole are antimycotic agents that are used to treat M. nanum and T. rubrum. Of three human ... antimutagenic and anticarcinogenic activities. Both neem seed and neem leaves are capable of killing M. nanum. The minimum ... Like many other dermatophytes, M. nanum is tolerant of the antifungal agent cycloheximide. In addition, M. nanum also exhibits ...

*Anticarcinogen

... s are different from anticarcinoma agents (also known as anticancer or anti-neoplastic agents) in that ... Confirmation that a substance possesses anticarcinogenic activity requires extensive in vitro, in vivo, and clinical ... An anticarcinogen (also known as a carcinopreventive agent) is a substance that counteracts the effects of a carcinogen or ... anticarcinoma agents are used to selectively destroy or inhibit cancer cells after cancer has developed. Interest in ...

*Erdal Can Alkoçlar

Those agents are primarily used in order to treat burns, to treat sexual dysfunction both as oral and transdermal formulations ... He holds the patents of 67 anti-carcinogenic formulations, 101 Anti-viral formulations and 23 metabolic regulator ingredients. ... potency to Proviron in terms of lipolysis and Trenbelone in terms of muscle gain with the absence of those two anabolic agents ...

*Tomatine

Arneson, P. A., and R. D. Durbin.; Studies on the mode of action of tomatine as a fungitoxic agent.; Plant physiology 43.5, ... Friedman, Mendel (2013). "Anticarcinogenic, Cardioprotective, and Other Health Benefits of Tomato Compounds Lycopene, α- ... Arneson, P.A., Durbin, R.D.; Studies on the Mode of Action of Tomatine as a Fungitoxic Agent.; USDA Pioneering Research ... Tomatidine is a natural small molecule inhibitor of skeletal muscle atrophy, and a potential therapeutic agent for aging- ...

*Decaffeination

These agents help speed up the process and minimize the "washed-out" effects that water alone might have on the taste of ... but also because they have been shown to have anticarcinogenic, antimutagenic, antioxidative, and antimicrobrial properties. ... "Chemical agents and related occupations, Volume 100F. A review of human carcinogens" (PDF). International Agency for Research ... Although it is mildly toxic and carcinogenic, its use as a decaffeination agent is allowed by the US Food and Drug ...

*P53 upregulated modulator of apoptosis

p53, and with it PUMA, is activated due to DNA damage caused by a variety of genotoxic agents. Other agents that induce p53 ... Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (June 2009). "Multiple molecular targets of resveratrol: Anti-carcinogenic ... Therapeutic agents targeting PUMA for cancer patients are emerging. PUMA inducers target cancer or tumor cells, while PUMA ... Yu J, Yue W, Wu B, Zhang L (May 2006). "PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation". Clin. ...

*Gary H. Posner

Posner's recent research has been focused on applying organic synthesis to the preparation of novel medicinal agents including ... correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes". Journal of Medicinal Chemistry ...

*Co-carcinogen

A chemical may both have anti-carcinogenic properties and yet still be a co-carcinogen in combination with some carcinogens. ... a cancer chemopreventive agent or a co-carcinogen?". Mutation Research/Reviews in Mutation Research. 543 (3): 195-200. doi: ... carcinogens or anti-carcinogenic. In recent years, people substitutes health supplement for healthy meal. Some myths even state ...

*Withaferin A

Therefore, withaferin A can be a potential therapeutic agent for the treatment of cervical cancer without major side effects. ... anti-metastasis and anti-carcinogenic properties. Withanolides are a group of naturally occurring C28- steroidal lactones. They ... Lee, In-Chul; Choi, Bu Young (2016). "Withaferin-A-A Natural Anticancer Agent with Pleitropic Mechanisms of Action". ... 2007). "The tumor inhibitor and antiangiogenic agent Withaferin A targets the intermediate filament protein Vimentin". ...

*Genistein

This effect may be responsible for both anticarcinogenic and carcinogenic potential of the substance. It was found to ... Antimicrobial Agents and Chemotherapy. 50 (11): 3770-8. doi:10.1128/AAC.00578-06. PMC 1635224 . PMID 16954323. Si, Hongwei; Liu ... of Combination Effects for the Induction of Micronuclei in Mouse Lymphoma Cells by Binary Mixtures of the Genotoxic Agents MMS ...

*Methaneseleninic acid

Implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine". Nutrition Cancer. 40: 34- ... that methaneseleninic acid shows promise as a sensitizing agent for ABT-737-induced apoptosis of several cancer lines, and that ...

*DMOZ - Health: Specific Substances: Alcoholic Beverages: Benefits: Wine

Chemical & Engineering News: Anticancer Agents Found in Aged Wine Article describes findings at the Research Center for ... may be responsible for wine's anti-carcinogenic and anti-arteriosclerotic properties. (December 19, 1997) ...
Full Text CA-97-014 PIVOTAL CLINICAL TRIALS FOR CHEMOPREVENTION AGENT DEVELOPMENT NIH GUIDE, Volume 26, Number 7, March 7, 1997 RFA: CA-97-014 P.T. 34 Keywords: Cancer/Carcinogenesis Clinical Trial Chemopreventive Agents National Cancer Institute Letter of Intent Receipt Date: April 3, 1997 Application Receipt Date: May 22, 1997 PURPOSE The Division of Cancer Prevention and Control (DCPC), National Cancer Institute (NCI) invites applications to further the drug development efforts of the Chemoprevention Branch by carrying out intermediate-sized Phase II/III efficacy trials of promising chemopreventive agents in major cancer target organs, particularly prostate, breast, lung, colon, and bladder. Currently, most NCI-sponsored Phase II clinical trials enroll fewer than 100 participants and evaluate a spectrum of potential SEBs as study endpoints over a relatively brief study period (2 weeks 6 months). This is in contrast to the large Phase III clinical chemoprevention trials with tamoxifen, ...
A polymer scale preventive agent for use in the polymerization of a monomer containing an ethylenic double bond is provided. The agent includes (A) a condensation reaction product obtained by reacting an aldehyde compound and a hydroxynaphthalene-based compound in the presence of a reducing agent, and (B) a polymer compound containing a nitrogen atom. This agent is capable of forming a coating with satisfactory scale prevention properties on inner wall surfaces of a polymerization vessel with a single-stage application, enabling the production process time to be shortened and the productivity and quality of polymeric products improved.
3,3-Diindolylmethane (DIM) is a naturally occurring indole, which is currently under investigation as a potential chemopreventive agent. The concentrations of DIM in plasma, liver, kidney, lung, heart, and brain tissues were determined following oral administration of two different formulations to mice (250 mg/kg). Mice were sacrificed periodically from 0 to 24 h after administration of either a crystalline or an absorption-enhanced formulation (Bio-Response-DIM; Indolplex) of DIM, and plasma and tissue concentrations were determined by high-performance liquid chromatography (UV detection, 280 nm). A physiologically based pharmacokinetic (PBPK) model was developed to characterize the pharmacokinetic properties of the two different formulations. The final model included parameters reflecting linear first-order absorption, systemic clearance, and distributional clearance in the remainder compartment, which were considered independent of formulation. All pharmacokinetic profiles from the two ...
Background Aspirin has generated a significant interest in recent years as a potential chemopreventive agent supported by strong evidence from epidemiological data; however, the mechanisms are not well understood. The objective of this dissertation is to identify novel cyclooxygenase (COX)-independent pathways by which aspirin exerts its anticancer effects in epithelial cancer cell lines. We investigated the effect of aspirin on p53, glucose 6-phosphate dehydrogenase (G6PD), and c-Myc, all of which are known to play a major role in cancer development. p53 is a tumor suppressor protein, often mutated in cancers causing its inactivation. Expression of G6PD is elevated in many cancers, and this significantly contributes to increased synthesis of DNA and RNA through the production of pentose sugars. c-Myc is a transcription factor (TF), which is mutated and constitutively activated in 20% of all cancers. The studies on p53 and G6PD are an extension of the previous work carried out in our laboratory, in
Trials are being conducted to determine the authenticity of consuming Indole-3-Carbinol supplements to prevent illnesses, particularly cancer. Although it does not provide an active cure to cancer, Indole-3-Carbinol is scientifically proven to support the health of reproductive organs and cellular reproduction for both men and women. It also assists in detoxifying the intestines and liver.As an antioxidant, it stimulates the production of enzymes that detoxify toxins and protects cell structures including DNA. Lycopene is another vegetable antioxidant with proven health benefits.With possible anti-carcinogenic, antioxidant and anti-atherogenic effects, this vegetable component is only just being acknowledged as a solution to a variety of health issues Indole-3-Carbinol is currently being clinically researched as a cancer preventive agent by the National Institutes of Health.. Other names for Indole-3-Carbinol:. I3C, 3-Indolylcarbinol, 1H-Indole-3-methanol, 3-Hydroxymethyl Indole, 3 Hydroxymethyl ...
3825 The isothiocyanate sulforaphane (SF) has received increasing interest of late as a promising chemopreventive agent in several model systems. As a natural product derived from cruciferous vegetables, SF has low toxicity, yet is able to regulate many factors important in tumorigenesis, including inflammation, cell cycle and apoptosis. Our current work is focused on determining whether SF is a good candidate for chemoprevention of UV-induced non-melanoma skin cancer (NMSC). Although there have been two published studies using SF in long-term mouse tumorigenesis experiments, the issue of whether SF can protect against NMSC when used concurrently with UVB treatment has not been addressed. We have therefore treated female SKH-1 hairless immunocompetant mice, 20 per group, with either UVB alone, UVB+Acetone, UVB+1μmol SF or UVB+2.5μmol SF. Mice were treated topically three times a week with either vehicle or SF, one hour prior to treatment with UVB. The UVB dosage started at 0.9 kJ/m2 and ...
Despite the intensive efforts and substantial advances that have occurred through focusing on improving treatment, cancer is still a leading cause of death worldwide. Many have argued that this could be avoided by focusing on cancer prevention, which has now entered the arena of targeted therapies. During the process of identifying preventive agents, dietary phytochemicals have emerged as modulators of key cellular pathways. By molecular modeling of the interactions of targeted proteins with these chemopreventive agents, we have provided knowledge for a better understanding of how these preventive agents work. Such knowledge will help the translation to new clinical practice of preventive medicine.. Citation Information: Cancer Prev Res 2011;4(10 Suppl):CN07-02. ...
Introduction: Chronic inflammation is widely recognized as an underlying etiological factor in carcinogenesis; there is enough evidence to support the use of non‐steroidal anti‐inflammatory drugs (NSAIDs), and more importantly, their chemically‐modified NO‐releasing prodrugs (NO‐NSAIDs) as promising chemopreventive agents. Metabolic activation of organic nitrate‐containing NO‐aspirins may lead to a cytotoxic "activated" linker (a quinone methide), raising safety concerns. Replacement of organic nitrates with N‐diazeniumdiolates as a second‐generation NONO‐NSAIDs allowed us to conduct a head‐to‐head comparison between NCX‐4016 (NO‐aspirin), CVM‐01 (NONO‐aspirin), and aspirin as analgesic, anti‐inflammatory, and anti‐pyretic agents with no significant gastrointestinal toxicity.. Methods: a) Anti‐inflammatory: paw edema induced by intraplantar injection of 100 µL of 1% carrageenan, paw volumes measured up to the tibiotarsal joint immediately prior to ...
It has been demonstrated and confirmed that certain nonsteroidal anti-inflammatory drugs which inhibit cyclooxygenase and the synthesis of prostaglandins and other eicosanoids, can reduce the formation of both colon polyps and cancers in experimental animals given known carcinogens. Additionally, the results of several epidemiologic studies have suggested that nonsteroidal anti-inflammatory drugs may reduce the risk of colon polyp occurrence and/or colon cancer mortality. We have carried out a study to evaluate the methodology of the measurement of prostaglandin E2 (PGE2) in human colonic mucosa because its concentration may serve as a valuable intermediate marker of the pharmacological activity in Phase II studies of nonsteroidal anti-inflammatory drugs as colon cancer preventive agents. We studied all aspects of the actual measurement of PGE2 including the extraction efficiency of the PGE2 from the mucosa, the precision of the assay and calculation of the PGE2 content in terms of milligrams of ...
The committee examined the potential of these natural carcinogens to cause cancer, comparing the risk they pose to the risk from synthetic carcinogens. It also examined "anticarcinogens," substances that are associated with lowering the occurrence of cancer. After assessing the data on more than 200 known carcinogens in food -- including 65 naturally occurring substances -- the committee determined that both naturally occurring and synthetic chemicals appear to cause cancer in similar ways and can be evaluated in the laboratory using the same methods. However, screening and research must be dramatically improved before scientists can understand the role that dietary chemicals play in causing cancer ...
The first lesson is that it is not yet time for epidemiologists to abandon their fieldwork and become trialists. The good agreement between the observational studies and the trial on endpoints other than CHD confirms the utility and validity of observational studies as monitors of new preventive agents. Moreover, randomized trials cannot evaluate the long-term effects of preventive agents; we will continue to need observational studies to provide this important information. Indeed, long-term observational follow-up of the WHI participants for delayed effects will provide essential data on the lifetime risks and benefits of HRT use among former users.. What can we learn from the CHD discrepancy? Two lessons come to mind. The first is that large sample sizes may be necessary, but they are not sufficient for accurate answers. Bigger need not be better. In the presence of unrecognized residual confounding, the precision in risk estimates gained by large sample sizes can be misleading: a narrow ...
Antiangiogenics have shown to be effective and safe anticancer agents in preclinical animal tumor models but have had mixed results in clinical trials with advanced disease. One possible explanation for the lack of efficacy in these clinical trials could be due to the bulky size of tumors in patients with stage III/IV disease. In theory, antiangiogenics would be predicted to be more effective in preventing smaller avascular tumors from activating the angiogenic switch and thus would be an ideal class of compounds for use in a chemopreventative setting. TM is a potent antiangiogenic compound that has completed numerous phase I/II trials for solid tumors. Results from these clinical trials showed that TM is very well tolerated with minimal adverse effects (6, 11-15). The attractive safety profile of TM suggests that it may be amendable to long-term use and thus be developed as a chemopreventative agent.. Recent work from our laboratory showed that TM significantly retards the development of ...
Sigma-Aldrich offers abstracts and full-text articles by [Srilatha Badaboina, Hyoung-Woo Bai, Yun Hee Na, Chul-Hong Park, Tae Hoon Kim, Tae-Hoon Lee, Byung Yeoup Chung].
The overall hypothesis is that the combination of a low dose of the antiestrogen Raloxifene with omega-3 fatty acids will exert a synergistic breast cancer chemopreventive effect due to the crosstalk of their downstream cellular effects leading to decreased proliferation and increased apoptosis of premalignant mammary cells. Based on the investigators hypothesis that upregulation of functional estrogen receptors in the premalignant lesions is also responsible for the development of hormone independent tumors, the investigators postulate that the combination of antiestrogens and omega-3 fatty acids will reduce the development of both hormone-dependent and -independent tumors. At present, there are no known interventions able to decrease the development of hormone-independent tumors, which are more prevalent, more aggressive, leading to the patients demise. In addition, the investigators postulate that this approach will be safe since it will combine a lower and hence a less toxic dose of ...
The study, conducted by researchers at the Mayo Clinic College of Medicine in Scottsdale, Ariz., suggests this drug one day might be used to prevent and even treat breast tumors. Celebrex, marketed by Pfizer Inc., is a member of the general family of drugs that target the COX-2, an enzyme that plays a major role in arthritis pain and inflammation. "This COX-2 inhibitor represents a strong option for treatment of breast cancers, and a preventative agent for treatment of individuals with high risk of developing breast cancer or disease relapse," said Pinku Mukherjee, Ph.D., the senior author of the report ...
Women have more options than ever for fighting breast cancer. But many arent getting the best screening and care, resulting in missed cancers, over-aggressive...
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Effects of chemopreventive agents on the incidence of recurrent colorectal adenomas: a systematic review with network meta-analysis of randomized controlled trials Sajesh K Veettil,1 Nattawat Teerawattanapong,2 Siew Mooi Ching,3,4 Kean Ghee Lim,5 Surasak Saokaew,6–9 Pochamana Phisalprapa,10 Nathorn Chaiyakunapruk7,8,11,12 1School of Pharmacy/School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia; 2Division of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, Thailand; 3Department of Family Medicine, Faculty of Medicine and Health Sciences, 4Malaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, 5Clinical School, Department of Surgery, International Medical University, Seremban, Negeri Sembilan, 6Center of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Phayao, 7School of Pharmacy, Monash University Malaysia, Selangor,
Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Cancer chemoprevention, chemical carcinogenesis, cytochrome P450, gluconasturtiin, glucosinolates, isothiocyanates, CRUCIFEROUS VEGETABLE CONSUMPTION, GLUTATHIONE-S-TRANSFERASE, DNA ADDUCT FORMATION, PHASE-II ENZYMES, EPIC-HEIDELBERG COHORT, ACETYL-L-CYSTEINE, A/J MOUSE LUNG, BENZYL ISOTHIOCYANATE, F344 RATS, BRUSSELS-SPROUTS ...
Research in my laboratory focuses on understanding the molecular mechanisms of selenium in cancer chemoprevention and the role of reactive oxygen species in carcinogenesis. Selenium is an essential trance element for human health. Selenium deficiency is known to be linked to the risk of certain cancers. Recent clinical studies demonstrated that selenium is a promising chemopreventive agent for prostate and colon cancers. We are currently studying redox-mediated and epigenetic effects of selenium on cell cycle and apoptosis in human prostate cancer cells. We are interested in determining how selenium modulates intracellular redox state, DNA methylation, and histone protein modifications to regulate the expression of genes involved in protection against oxidative stress, tumor suppression, cell cycle, and apoptosis. We also study combinations of selenium with other dietary chemopreventive agents, DNA methylation inhibitors, and histone deacetylase inhibitors for maximizing cancer prevention and ...
TY - JOUR. T1 - Application of pharmacogenomics to dietary cancer chemoprevention. AU - Prawan, Auemduan. AU - Khor, Tin Oo. AU - Li, Wenge. AU - Kong, Ah Ng Tony. PY - 2007/9. Y1 - 2007/9. N2 - Many lines of evidence demonstrate that certain dietary phytochemicals have cancer chemopreventive effects. These dietary phytochemicals or chemo-preventive agents can suppress or block carcinogenesis by 1 enhancing the biotransformation enzymatic activities for efficient elimination of carcinogens or reactive oxidative or nitrosative species (ROS/RNS); 2 suppressing the growth/inflammatory signaling pathways involved in cancer cell proliferation; and 3 modulating phase II detoxifying/antioxidant enzymes, e.g. glutathione S-transferases (GST), NAD(P)H-quinone reductase 1 (NQO1), UDP-glueuronosyltransferases (UGT), and antioxidant enzymes such as gamma-glutamylcysteine synthetase (γ-GCS) and heme oxygenase 1 (HO1). Comparison of gene expression profiles among Nrf2 wild type and Nrf2 knockout mice showed ...
This has been confirmed by other researchers. "The mammalian lignan enterolactone is a major metabolite of plant-based lignans that has been shown to inhibit the growth and development of prostate cancer," wrote Chinese researchers, recently. Working with prostate cancer cells in the laboratory, the scientists found that enterolactone, derived from plant lignans, caused cancer cells to undergo apoptosis, or controlled cellular suicide. "Our findings encourage further studies of enterolactone as a promising chemopreventive agent against prostate cancer," the researchers concluded.23 Finnish researchers working with animal models of human prostate cancer also concluded, "… dietary HMR [lignan] started at the early phase of the tumor development inhibits the growth of… human prostate cancer xenografts in athymic male mice."13. Enterolactone such as that derived from Norway spruce acts via numerous mechanisms to benefit aging mens health. Increasing estrogen levels in aging men are believed to ...
The studys results suggest that the benefits of tamoxifen to prevent cancer can sufficiently compensate for its side effects in post-menopausal women under age 55 years who have an increased risk of developing breast cancer.. Research has shown that tamoxifen can protect against breast cancer for years after treatment ends, but identifying the group of women who can most benefit from the drug as a cancer preventive agent, without experiencing serious side effects, is a challenge. Side effects of the drug can include pulmonary embolism, endometrial cancer, deep vein thrombosis, and cataracts, as well as hot flashes and early menopause.. To investigate those women who would benefit the most from taking tamoxifen as a cancer preventive drug, Peter Alperin, MD, of Archimedes Inc. in San Francisco, and his colleagues used a mathematical model to simulate a post-menopausal population under age 55 years in a virtual clinical trial comparing tamoxifen treatment with no treatment. The investigators ...
in which A is a hydrocarbon ring optionally be cross-linked with a lower alkylene or an oxygen atom; said lower alkylene and hydrocarbon ring may optionally be substituted by at least one alkyl; and p and q are independently 0, 1 or 2),G is N, CH or COH, and --Ar is an aromatic heterocyclic group, an aromatic hydrocarbon group, benzoyl, phenoxy, or phenylthio, orG is a carbon atom, and --Ar is biphenylmethylidene,where said aromatic heterocyclic group, aromatic hydrocarbon group, benzoyl, phenoxy or phenylthio, and biphenylmethylidene may optionally be substituted by at least one group selected from a lower alkyl, a lower alkoxy and a halogen atom},or an acid addition salt thereof.(2) The therapeutic/preventive agent for cognitive dysfunctions according to the above (1), which is a therapeutic agent for senile dementia.(3) A therapeutic/preventive agent for cognitive dysfunctions, which comprises as an active ingredient an imide derivative of the above formula [1], wherein --Ar is an aromatic ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk PA-05-059. NCI
Phenethyl isothiocyanate (PEITC) is a particularly beneficial type of isothiocyanate that shows promise as a treatment for, and preventative of, cancer.
Interest in potential cancer chemopreventive and therapeutic properties of dietary ingredients, which are generally more tolerable in the human body ( 15), has increased in recent years, especially for the cancers that usually do not respond well to currently available therapies ( 17). Therefore, it is not surprising that chemoprevention of colon cancer, the leading cancer-related death in Western countries, is becoming more attractive. One of the dietary ingredients that possess anti-inflammatory and/or antioxidant properties is curcumin. Epidemiologic data suggest that curcumin may be responsible for the lower colon cancer rate in India and Southeast Asia ( 39). Based on that and its long history of consumption without any adverse health effects, curcumin is considered to be a safe chemopreventative agent ( 15).. Although it was suggested previously that curcumin-induced apoptosis is mediated through the impairment of the ubiquitin-proteasome pathway ( 40), the exact mechanism was not fully ...
Not every woman should use these preventive agents, but we believe women who are at increased risk for breast cancer should be given the option, because in some cases the magnitude of the risk reduction is large. For some women, these therapies can reduce the risk of breast cancer by up to 50%," said Kala Visvanathan, MBBS, FRACP, MHS, Co-Chair of the Guideline Panel and Associate Professor of Epidemiology and Oncology at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center.. Risks and Benefits of Therapy. The guideline provides new insight on the risks and benefits for tamoxifen and raloxifene use in postmenopausal women. The risk and benefit profile for both agents varies by age, race, level of breast cancer risk, and history of hysterectomy. The guideline emphasizes that women should discuss both the risks and benefits of these drugs with their doctors before deciding whether to take these drugs for prevention.. "We now have a ...
Perhaps the best way to fight cancer is to prevent it from developing in the first place, and based on newly published research from investigators at the University of Wisconsin-Madison, nanoparticles may be able to make cancer chemoprevention a reality. Using nanoparticles made of a biocompatible polymer, the investigators were able to encapsulate a molecule isolated from green tea that triggers apoptosis and inhibits angiogenesis, two key biochemical events that could prevent cancer. Hasan Mukhtar, Ph.D., led the team that published its results in the journal Cancer Research. One of the chief issues in chemoprevention-the use of biologically active molecules to thwart cancer before it gains a foothold in the body-is that any such agents must be exceedingly safe, since it is likely that a person at risk for cancer would need to take the chemopreventive agent on a regular basis for a long time. Because of this requirement, many investigators have been screening naturally occuring molecules for ...
VELASCO-BEJARANO, Benjamín et al. Diindolylmethane Derivatives as Apoptosis Inductors in L5178y Cells. J. Mex. Chem. Soc [online]. 2008, vol.52, n.3, pp.224-228. ISSN 1870-249X.. Cell growth and division are highly regulated processes, although a notable exception is provided by the cancer cell, which arises as a variant that has lost the usual proliferation control pathways. Consequently, there is growing interest in the search for antitu-moral substances with high efficacy, low toxicity, and minimum side effects. In this sense, we synthesize eight diindolylmethane derivatives and the in vitro antitumor activity against murine L5178Y lymphoma cells was assessed. The preliminary results showed that the substituent and its position on the phenyl group were important for its potency against the lymphoma cells tested. Compound 3a was the most active compound with 93 % cell grown inhibition and 71.04% of apoptosis.. Palabras clave : DIM derivatives; apoptosis; cytotoxic effects; L5178Y cells. ...
B144 Hepatocellular carcinoma (HCC) is a common complication of hepatitis C cirrhosis. Because of immigration from countries with a high prevalence of hepatitis B, as well as the increasing age of Americans who contracted hepatitis C during the 1960s through 1980s, the incidence of HCC is increasing in the United States, and is projected to double between 2000 and 2010. At present, there is no effective chemopreventive agent for HCC. Epidemiologic studies have reported an increased risk for HCC among males and in patients with cirrhosis, older age and elevated serum level of alpha-fetoprotein (AFP). SAMe has been used as a drug in Italy and other European countries for more than 20 years. It has an excellent safety profile. In the body, SAMe is a component of the methionine cycle and is found in all cells. Inactivation of methionine adenosyl transferase in cirrhosis reduces the conversion of methionine into SAMe. The resulting reduction in SAMe level may contribute to decreased synthesis of ...
Turmeric is the most studied herb with coumarins. A study evaluated the chemopreventative effects of curcumin, the most active coumarin, on radiation- induced tumors in rat mammary glands. One control group was fed a basic diet while the other control group was fed a diet containing 1% curcumin. The control group fed curcumin had 28% reduction in tumors while 84% of the other group developed mammary tumors. Other studies also show that curcumin inhibits chemically-induced carcinogenesis of the skin, colon, and stomach. ...
Chronic inflammation and nuclear factor-kappa B (NFkappaB) have been implicated in prostate cancer development; thus, dietary factors that inhibit NFkappaB may serve as effective chemo-preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the United States, which has prompted interest in the potential chemopreventative action of Asian dietary components such as soy and green tea. This study examined the effects of dietary soy and tea on NFkappaB activation and inflammation in vivo using a hormone-induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy, tea, or soy+tea. NFkappaB activation and inflammatory cytokines were measured post implantation. The combination of soy and tea suppressed NFkappaB p50 binding activity and protein levels via induction of IkappaBalpha. Soy and tea also decreased prostate inflammatory infiltration, increased Bax/BcL2 ratio and ...
Despite recent advances in medicinal chemistry, intrinsic and acquired resistance to chemotherapy treatments and the possibility of relapse present drawbacks in the treatment of breast cancer [39]. Because of the clear risks posed by chemotherapy, researchers worldwide have started searching for natural products that have better anti-carcinogenic activity without side effects. In addition, we believe that long chemotherapy treatment weakens the immunological defense system of the body and leaves patients susceptible to other infections and diseases. Radiation therapy is another treatment to combat cancer but also shows several potentially harmful side effects including weakened immune system and the potential to induce carcinogenesis itself. Therefore, there is an urgent need to develop chemoprevention approaches for the prevention of cancer. Chemoprevention is an important function area of oncology that focuses on the prevention of cancer using natural or synthetic agents. Recently, natural ...
Taking oxygen as a "vitamin O" supplement is a practice not endorsed by any major medical organization. There appears to be two types of vitamin O products available on the market. The first is an expensive health supplement that is composed largely of salt water and "stabilized" or "aerobic" oxygen, and is marketed under many different brand names. Companies, such as RGarden have advertised vitamin O (without germanium) as a purported cure or preventive agent for serious diseases such as cancer, heart disease, and lung disease. It has also been claimed that when taken by mouth, vitamin O supplements may enrich the bloodstream with supplemental oxygen. The second vitamin O product currently available contains the element germanium, which when synthetically derived has been said to be potentially nontoxic and safe at high doses. The various health claims for use of vitamin O have not been substantiated with scientific evidence. However, numerous product testimonials mention the effects of vitamin ...
The number one risk for colon cancer is age. Colon cancer has also become one of the most curable forms of cancer through improved screening and diagnostic techniques.
DESCRIPTION (provided by applicant): Principal Investigator/Program Director (Last, First, Middle): Blattner, Frederick R. Abstract: The goal of this proposal is to develop methods and strains for manufacturing plasmid DNA of extraordinary purity in very large quantity for therapeutic use. Specifically we propose to use genetic techniques to lower the level of contaminating endotoxin in plasmid DNA preparations by many orders of magnitude. The advent of DNA based vaccines, gene therapy approaches and plasmid based RNA interference (RNAi) has opened the way for DNA to be used directly as a therapeutic or preventative agent against viral or other infectious diseases, some forms of cancer and possibly to ameliorate inborn genetic diseases. This has created a market for large quantities of injection grade plasmid DNA. For clinical trials, and ultimately administration to patients, DNA preparations must be manufactured to the highest specifications of quality and safety. Removal of endotoxin is ...
such a new brilliant approach to eradicate cancer! this is interesting and beneficial as the bacterial proteins termed azurin & ATP-01 not only found effective in anticancer but also cancer preventive activity. Besides, because those bacteria are naturally-occurring human bacterial symbionts, i think it is higher chances to reduce/prevent immunogenicity and always non-toxic to human. its great to hear that ATP-01 also effective in anti-HIV/AIDS activity, should be a great invention and discovery! ...
11. Garlic, For centuries garlic has been used as natural medicine to prevent or treat a wide range of diseases and conditions. Multiple studies published throughout the last 10 years confirm that using small amounts of herbs and spices in recipes can yield big health benefits. A review of garlics impact on heart health found that this flavorful herb may help to improve cholesterol and triglyceride levels and aid in blood clotting. Other studies have showed that consuming garlic may help protect against stomach and colorectal cancers. You can reap garlics health benefits by chopping it finely to release allinase, an enzyme that aids in the formation of garlics cancer-protective compounds. Since cooking stops the activity of this beneficial enzyme, its best to let crushed garlic "stand" for 10 minutes after chopping, before adding it to heat - this prevents total loss of its anti-carcinogenic activity ...
The article discusses research indicating that stilbenes, the phytochemicals in grapes and berries, may help prevent cancer of the colon.. ...
New research published in JAMA Internal Medicine suggests that anticoagulant warfarin may reduce the incidence of cancer in older adults.
Reducing the size, weight, and density of stools to the norm, is the most important and effective step toward the goal of preventing colorectal cancer.
Learn more about Diindolylmethane at Wesley Medical Center DIM Uses Principal Proposed Uses Reducing Cancer Risk Other...
Learn more about Diindolylmethane at Largo Medical Center DIM Uses Principal Proposed Uses Reducing Cancer Risk Other...
Learn more about Diindolylmethane at Doctors Hospital of Augusta DIM Uses Principal Proposed Uses Reducing Cancer Risk ...
The new nanoparticle, which delivers the drug in a form activated when it reaches its target, also treats tumors more effectively than the unadorned drug in mice.
Introduction and objective: The anticarcinogenic potential of milk fat can be attributed to its antioxidant, anti-inflammatory, immunostimulatory properties as well as the presence of compounds with antimutagenic effects. In view of the high incidence of cancer the aim of this article was to...
Buy DIM Diindolymethane Capsules. DIM Diindolymethane aids healthy estrogen metabolism and helps balance hormones for men and women. We offer it for only...
Pure Encapsulations Indole-3-Carbinol 200 mg is a cruciferous phytonutrient that promotes prostate, breast and cervix health. Made in USA.
Learn more about Indole-3-Carbinol at Grand Strand Medical Center Tipos de Complementos / Nombres Alternativos : I3C Uses Principales Usos Propuestos Prevenció...
CARBINÓL, carbinoli, s.m. Denumire veche a alcoolului metilic. - Din fr. carbinol. Trimis de valeriu, 11.02.2003. Sursa: DEX 98  CARBINÓL s. v. alcool metilic, metanol. Trimis de siveco, 05.08.2004. Sursa: Sinonime  carbinól s. m., pl.…
Title: Mouse Prostate Proteome Changes Induced by Oral Pentagalloylglucose Treatment Suggest Targets for Cancer Chemoprevention. VOLUME: 11 ISSUE: 7. Author(s):J. Zhang, K. Nkhata, A. A. Shaik, L. Wang, L. Li, Y. Zhang, L. A. Higgins, K. H. Kim, J. D. Liao, C. Xing, S.-H. Kim and J. Lu. Affiliation:Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center. 1300 S. Coulter St, Amarillo, TX79106, USA.. Keywords:Cancer chemoprevention, iTRAQ, penta-1, 6-O-galloyl-beta-D-glucose (PGG), prostate, proteomic, tolerated dose determination, transgenic adenocarcinoma of mouse prostate, heat shock protein 5, fatty acid synthase, glutathione S-transferase mu. Abstract: Recent in vitro and in vivo preclinical studies have suggested that the Oriental herbal compound penta-1, 2, 3, 4, 6-O-galloyl-beta-D-glucose (PGG) is a promising chemopreventive agent for prostate cancer. Little is known of its safety for chronic chemoprevention use and virtually nothing is known of ...
TY - JOUR. T1 - Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate. AU - Chen, Kun Ming. AU - Sacks, Peter G.. AU - Spratt, Thomas E.. AU - Lin, Jyh Ming. AU - Boyiri, Telih. AU - Schwartz, Joel. AU - Richie, John P.. AU - Calcagnotto, Ana. AU - Das, Arunangshu. AU - Bortner, James. AU - Zhao, Zonglin. AU - Amin, Shantu. AU - Guttenplan, Joseph. AU - El-Bayoumy, Karam. PY - 2009/5/22. Y1 - 2009/5/22. N2 - Tobacco smoking is an important cause of human oral squamous cell carcinoma (SCC). Tobacco smoke contains multiple carcinogens include polycyclic aromatic hydrocarbons typified by benzo[a]pyrene (B[a]P). Surgery is the conventional treatment approach for SCC, but it remains imperfect. However, chemoprevention is a plausible strategy and we had previously demonstrated that 1,4-phenylenebis(methylene)selenocyanate (p-XSC) significantly inhibited tongue tumors-induced by the synthetic 4-nitroquinoline-N-oxide (not present ...
The main goal of cluster headache preventive therapy is to make a patient cluster-free on preventives even though they are still in a cluster cycle. Preventive agents are absolutely necessary in cluster headache. The maintenance preventive should be started at the time a transitional agent is given. Sometimes very large dosages, much higher than that suggested in the literature, are necessary when treating cluster headache. It is not uncommon for cluster patients to require several preventive medications at once to get better results. Most physicians treating cluster will increase the dosages of the preventive agents very quickly to get a desired response.. Preventive medications are only used while the patient is in cycle and then are tapered off once a cluster period has ended. If a patient decides to remain on a preventive agent even after their cluster cycle has ended, it does not appear to prevent a subsequent cluster period from starting.. Verapamil. ...
Recent research on citrus limonoids has specifically focused on isolation, elucidation of structures, and the effects of these compounds on different biological systems [9-16, 29-32]. One focal point in citrus limonoid research has been on their ability to induce the activity of phase II detoxification enzymes. A recent study by Wark et al. suggests that habitual consumption of fruits and vegetables positively correlated with human rectal GST activity [33]. It is thus possible that an increase in the activity of phase II enzymes enhances the ability of an organism to effectively detoxify carcinogens. Therefore, any substance that increases the activity of phase II enzymes may be a potential chemopreventive agent with the ability to inhibit chemically induced cancer formation [21]. Several studies have attributed the induction of these enzymes to the structural components of limonoids. The furan moiety has been thought to be one of the components responsible for induction of GST activity [21]. ...
TY - JOUR. T1 - 2-phenethyl isothiocyanate, glutathione S-transferase M1 and T1 polymorphisms, and detoxification of volatile organic carcinogens and toxicants in tobacco smoke. AU - Yuan, Jian Min. AU - Murphy, Sharon E.. AU - Stepanov, Irina. AU - Wang, Renwei. AU - Carmella, Steven G.. AU - Nelson, Heather H.. AU - Hatsukami, Dorothy. AU - Hecht, Stephen S.. PY - 2016/7. Y1 - 2016/7. N2 - Cigarette smoke contains relatively large quantities of volatile organic toxicants or carcinogens such as benzene, acrolein, and crotonaldehyde. Among their detoxification products are mercapturic acids formed from glutathione conjugation, catalyzed in part by glutathione S-transferases (GST). A randomized phase II clinical trial with a crossover design was conducted to evaluate the effect of 2-phenethyl isothiocyanate (PEITC), a natural product formed from gluconasturtiin in certain cruciferous vegetables, on the detoxification of benzene, acrolein, and crotonaldehyde in 82 cigarette smokers. Urinary ...
Rationale: Prostate cancer is a frequently observed malignancy in men, especially in elderly men. Besides diagnosis and treatment, also prevention of prostate cancer is an important point of interest to reduce the incidence and mortality of prostate cancer. Selenium is considered to be a promising chemopreventive agent for prostate cancer. Exact mechanisms of chemoprevention by selenium are not fully understood. However, it is expected that selenium (among other effects) directly affects gene expression in the prostate.. Objective: The aim of this study is to get insight into bioavailability of selenium in prostate tissue and changes of gene expression profiles that might be responsible for selenium-induced chemoprevention. To meet this objective, the relationship between dietary selenium intake and changes in gene expression profiles, tissue selenium levels and blood flow in prostate tissue will be examined.. Study design: The present study is designed as a double-blind, randomized and ...
Gammadelta T cells are found largely within the epithelium and recognize antigens differently than their alphabeta T cell counterparts. TCR delta-/- knock out mice exhibit a rapid tumor onset, along with increased tumor incidence. Although limited, research demonstrates that nutrients and bioactive food components can influence gammadelta T cell cytotoxicity, cytokine secretion, and proliferative capacity, and the results are nonetheless intriguing. Among other functions, gammadelta T cells play a role in immunosurveillance against malignant cells, as shown by the T cell receptor (TCR)delta-/- knock out mice that exhibit a rapid tumor onset and increased tumor incidence. Some common dietary modifiers of gammadelta T cell numbers or activity are apple condensed tannins, dietary nucleotides, fatty acids, and dietary alkylamines. A recent clinical study demonstrated that ingesting a fruit and vegetable juice concentrate increased the number of circulating gammadelta T cells. Clinical studies also document
Abstract: DESCRIPTION (provided by applicant): Since former smokers are at an elevated risk to develop lung cancer and about half of all new lung cancer incidences are among former smokers, there is an urgent need to develop safe and efficacious chemopreventive agents to help former smokers control this deadly disease. Our long-term goal is to develop a Complementary and Alternative Medicine (CAM) modality based on natural food and beverages that will help former smokers to prevent or delay lung cancer development. The results of our recent studies strongly support the notion that kava, a long-standing beverage in the South Pacific Islands, is promising to prevent post-carcinogen lung cancer development, potentially through suppressing NF-kB activation. Our preliminary data also suggest that kavas chemopreventive efficacy can be improved by enriching its chemopreventive constituents. Such optimization may also lead to improved safety. The objectives of this application, therefore, are to ...
In this present study, we have shown that both RPFNA and DL are highly tolerable procedures (none of our subjects experienced bleeding, pain, or other complications with either procedure), and that once adequate samples are obtained, cytology was similar in DL and RPFNA samples. However, when the entire subject cohort was considered, the success rate of obtaining adequate samples was higher for the RPFNA versus the DL procedure.. Compared with long-term phase III breast cancer prevention trials, the advantage of short-term breast cancer prevention trials is that they do not require a large cohort of participants, are conducted over shorter periods of time, and are therefore more cost-effective. Cancer incidence is not the end point; instead, the aim of short-term prevention trials is to evaluate tissue surrogate end point biomarkers and the effect of potential preventive agents on such biomarkers over time (8). Besides, being used to monitor response to a preventive intervention, biological ...
U.S., March 8 -- ClinicalTrials.gov registry received information related to the study (NCT03069742) titled Study of Web-based Decision Aids for Increasing Breast Cancer Chemoprevention in the Primary Care Setting on Feb. 28. Brief Summary: The purpose of this randomized controlled trial (RCT) is to evaluate a decision support website (RealRisks) designed to inform patients about breast cancer prevention options. It is coupled with a physician-centered (BNAV) decision support website as part of clinical workflow in the primary care setting. The investigators hypothesize that improving accuracy of breast cancer risk perception and understanding of the risks and benefits of breast cancer risk lowering drugs, also known as chemoprevention, will increase the uptake of chemoprevention in the primary care setting. Study Start Date: November 2016 Study Type: Interventional Condition: Breast Neoplasm Intervention: Other: RealRisks RealRisks is a web-based patient decision aid with modules that present ...
The vitamins and plant-derived compounds currently under study have been highly effective at inducing apoptosis in breast cancer cells, thus demonstrating their immense promise as possible forms of treatment. However, the exact mechanism by which each compound signals a cell to die has not been determined because the intricate details of apoptosis are not yet fully understood. Programmed cell death involves multiple pathways; the exact pathway leading to apoptosis depends on the initiation signal and the particular genes and proteins that are activated. With a better understanding of apoptosis, scientists can apply that knowledge to design innovative breast cancer treatments, possibly involving vitamins and plant-derived compounds.. Literature Cited. American Cancer Society, Inc. Fast facts. American Cancer Society. 2000. (Nov. 2000). http://www.cancer.org/NBCAM_fastfacts.html. Danielsson, C., Mathiasen, I.S., James, S.Y., Nayeri, S., Bretting, C., Hansen, C.M., Colston, K.W., Carlberg, C. ...
Title: The Use of Nimesulide and Its Analogues in Cancer Chemoprevention. VOLUME: 6 ISSUE: 3. Author(s):Jean-Francois Renard, Fabien Julemont, Xavier d. Leval and Bernard Pirotte. Affiliation:Laboratoire de Chimiepharmaceutique, Natural and Synthetic Drugs Research Center, Universitede Liege, 1, Avenue de lHopital, Sart Tilman, B-4000 Liege, Belgium.. Keywords:Nimesulide, NS-398, cancer chemoprevention, NSAIDs, cyclooxygenase inhibitors, anti-proliferative, proapoptotic, N-arylmethanesulfonamides. Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs), which are known to be cyclooxygenase (COX) inhibitors, have been reported to exert anti-proliferative and pro-apoptotic effects on a variety of cancer cells. Since the COX-2 isoform was found to be overexpressed in a many human cancers, a particular attention was paid on the possible use of selective COX-2 inhibitors in cancer chemoprevention. The present review focuses on the state of the art in cancer research developed with COX-2 ...
3,3′-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage and kale, etc. Health Benefits 1. Antiinflammatory and chemopreventive effects on Skin In the examination of the effects of 3,3′-Diindolylmethane (DIM) on antiinflammatory and antitumor promotion activity in mouse skin and …. ...
Guar gum (G) is a simple characterized branched polysaccharide, which is frequently used in food industries. We prepared the gum C-glycosylated derivative (GG), and its sulphated derivative (SGG), aiming to characterize their cancer chemopreventive, and anti-inflammatory properties. Estimation of cancer chemopreventive activity, specifically anti-initiation, including the modulation of carcinogen metabolism and the antioxidant capacity, revealed that GG was a potent anti-initiator, where it inhibited not only the carcinogen activator enzyme, cytochrome P450 1A (CYP1A), but also induced the carcinogen detoxification enzymes glutathione-S-transferases (GSTs), while SGG inhibited both CYP1A and GSTs. SGG was an effective radical scavenger than GG against hydroxyl, peroxyl, and superoxide anion radicals. GG and SGG were found to modulate the macrophage functions into an anti-inflammatory pattern. Thus, both enhanced the macrophage proliferation and phagocytosis of fluorescein isothiocyanate ...
Older women who took aspirin at least twice a week had a lower risk of developing melanoma, a deadly form of skin cancer, a new study finds.. The study, published in the journal Cancer, looked at melanoma in about 60,000 Caucasian women ages 50 to 79, reported National Public Radio (NPR). (Researchers focused on light-skinned people because theyre at the highest risk for this type of cancer.). Over a 12-year period - and after controlling for risk factors like tanning and low use of sunscreen - women who took aspirin at least twice a week had a 21 percent lower risk of developing melanoma, researchers found.. "Were really excited aspirin could be used as a potential preventive agent for melanoma," study coauthor Jean Tang, M.D., of Stanford University Medical School, told NPR. "In terms of cancer prevention, a lower melanoma risk by 20 percent is very large and significant.". A 20 percent drop is significant, but to put things in perspective, only 548 women, or less than 1 percent of the ...
The basic cancer-related chemical and biological sciences, pathology, and epidemiology have contributed to the understanding that antimutagenesis and antiproliferation are the important general mechanisms of chemoprevention and to the development of antimutagenic and anti-proliferative agents as potential chemopreventive drugs. These disciplines have also provided the biochemical and histopathological bases for identifying intermediate biomarkers that can be used as surrogate end points for cancer incidence in clinical chemoprevention trials and for selecting cohorts for these trials. Particularly important as histological biomarkers of cancer are the cytonuclear morphological and densitometric changes that define intraepithelial neoplasia (IEN). IEN changes are on the causal pathway to cancer. They may serve as target lesions in Phase II chemoprevention trials and as standards against which other earlier cellular and molecular biomarkers can be evaluated. Strategies for the clinical evaluation ...
Ángeles Márquez, Quality director at Agrupalmería, outlined the nutritional and healthy properties of melons and watermelons, both rich in water, fibre, vitamins or antioxidants. In the case of watermelons, studies have revealed that, in addition to these, they also provide lycopene, a potent antioxidant considered a preventive agent for various types of cancer and with positive effects on the cardiovascular system; they are also a source of substantial amounts of vitamins A, C, and some of group B. Lastly, watermelon acts as a natural Viagra, given the vasodilator effect of lycopene, which gives elasticity to arteries and significantly improves the circulatory system ...
L-Glutamic acid 56-86-0 C5H9NO4,It can be used as a salt substitute, a dietary supplement and a flavor enhancer and used as a preventive agent for forming magnesium ammonium phosphate crystal in marine product, tins of shrimps and crabs etc_OKCHEM
A large number of substances that occur naturally in foods are carcinogenic (cancer-causing) when evaluated by the criteria scientists customarily use to assess the cancer-causing potential of synthetic substances. Other carcinogens are produced by cooking and by the actions of microorganisms. These natural carcinogens are more numerous, more widespread and in some cases more
The overall effectiveness of using probiotics for constipation is under investigation. While it has not been scientifically proven as a cure, probiotics work well as preventative agents for a number...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
This is the accepted version of the following article:Basar, N., Nahar, L., Oridupa, O. A., Ritchie, K. J., Talukdar, A. D., Stafford, A., Kushiev, H., Kan, A., and Sarker, S. D. (2016) Utilization of the Ability to Induce Activation of the Nuclear Factor (Erythroid-derived 2)-like Factor 2 (Nrf2) to Assess Potential Cancer Chemopreventive Activity of Liquorice Samples. Phytochem. Anal., 27: 233-238. doi: 10.1002/pca.2616., which has been published in final form at http://dx.doi.org/10.1002/pca. ...
Dietary fiber in processed food, supplements, and laxatives is a potent carcinogen and the primary cause of the intestinal mucosas inflammation.
Cancer chemoprevention involves the use of artificial or naturally occurring substances aimed to arrest or reverse the process of carcinogenesis. Numerous agents including dietary phytochemicals, anti-inflammatory drugs, vitamins and others are thought to possess preventative anti-cancer activities. Paul Ehrlich was the first to devise the idea that the immune system could suppress the increased frequency of carcinomas. This concept was further matured with the formulation of the
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Genestra DIM- 60 capsules • Diindolylmethane (DIM) formulation • Provides 75 mg of 3,3-diindolylmethane per day • Convenient vegetable capsule format • Vegan formula • Dairy-free, gluten-free Each capsule of DIM provides 25 mg of 3,3-diindolylmethane. The recommended daily dosage is 3 capsules.
Side effects were minimal and no different in both groups: of those taking placebo, 38 percent had grade 1 or 2 toxicity, and 3 percent had grade 3, compared to 39 percent and 1 percent, respectively in those taking the supplement. The study was stopped by the independent Data and Safety Monitoring Committee due to futility. The researchers did find that in a small group of the lung cancer patients who were never smoked, selenium did provide a small benefit; however, the size of the group of patients, 94, was too small to be statistically significant. "Our results demonstrate that selenium is not an effective chemoprevention agent in an unselected group of lung cancer patients, and its not something we can recommend to our patients to prevent a second cancer from developing or recurring," said Karp. "These findings also remind us that never smokers may represent a unique disease and should be an area for special consideration for research focus.. "Given our results and that of SELECT, ...
People who drink water contaminated with atrazine (ATR) over many years can experience problems with their cardiovascular system. Lycopene (LYC) has been shown to exhibit cardiovascular disease preventive effects. However, chemopreventive potential of LYC against ATR-induced cardiotoxicity remains unclear. To determine the effects of ATR and/or LYC on heart, mice were treated with ATR (50 mg/kg or 200 mg/kg) and/or LYC (5 mg/kg) by intragastric administration for 21 days. Histopathological and biochemical analyses, including analysis of ion concentrations (Na+, K+, Ca2+ and Mg2+), ATPases (Na+-K+-ATPase, Ca2+-ATPase, Mg2+-ATPase and Ca2+-Mg2+-ATPase) activities and the transcription of their subunits, were performed on heart. The results revealed that ATR led to decreased Creative Kinase (CK) activity and increased histological alterations. Furthermore, a significant change in Na+, K+ and Ca2+ content and the down-regulation of Na+-K+-ATPase and Ca2+-ATPase activities and the mRNA expression of ...
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A number of epidemiological studies have shown a strong association between regular consumption of cruciferous vegetables and a reduced risk of breast, prostate, and other cancers. These observational studies prompted researchers to investigate if these vegetables contained any unique anti-tumor bioactive agents that may account for these consistent findings. Experimental research subsequently identified that indole-3-carbinol is among a number of health-promoting phytonutrients discovered in cruciferous vegetables, which has now been tested in animal studies and proven to block cancer development involving the breast and prostate gland in lab animals. Human intervention trials have shown that indole-3 supplementation can reverse certain cases of cervical dysplasia and respiratory papillomas, and can change the estrogen profile of women in such a way as to help reduce risk of breast cancer development. This important biological agent is known to speed up the detoxification of many potentially ...
Natures Way DIM-plus Diindolylmethane 120 Vegetarian Capsules DIM-plus Difference-Patented Complex- DIM-plus contains BioResponse-DIM Complex and its patented, enhanced bioavailability delivery system for diindolylmethane. Enhanced Absorption-The bioavailability of DIM-plus is superior to regular diidolylmethane and its unstable precursor, indole-3-carbinol (I3C). With DIM-plus you are assured a stabilized and consistent dose of diindolylmethane. Protectamins Vegetables-DIM-plus also contains spinach, cabbage and concentrated broccoli for additional phytonutrients. Recommendation: Women take 2 capsules daily with food. Men take 2 capsules twice daily with food. Men take 2 capusles twice daily with food. For intensive Use (Women/Men): take up to double the recommended dose. Caution: Do not if pregnant or lactating. A harmless but noticeable change in urine color may occur during usage. Supplement Facts Serving Size 2 Capules/Servings Per Container 60 Amount Per Serving %DV Vitamin E
Researchers studied hundreds of Polish women living in the US and found that women who ate four or more servings of cabbage per week while preteens were 72% less likely to develop breast cancer as adults than the women who ate one serving or less of cabbage a week while preteens. Eating lots of cabbage as adults also provided significant cancer protection.. Dr. Donald Malins, a biochemist from Seatle, reported a new method fot identifying structural changes in the DNA of breast tissues. By using an instrument that bounces infrared radiation off the DNA and by analyzing the signals via a sophisticated computer, he was able to follow the structual damage to the DNA caused by free radicals.. Researchers agree with Malins that the development of cancer is a multistage process that usually takes decades to develop. In adults, cancer may take twenty or even thirty years to develop from the initial mutation of the DNA to its full-blown manifestation. In children, this process may develop more quickly ...
Behold, the fabulous "butt bus" currently making the rounds in Toronto and Laval. We launched these extra special additions to our GetYourButtSeen campaign to celebrate Colorectal Cancer Awareness Month 2011. Cant wait to come up with next years cheeky scheme!. Many thanks to Ogilvy Montreal, the creators of this daring (and fun!) campaign; to our partners at Hill & Knowlton for assisting with media outreach; to the Toronto Transit Commission and the Societé de Transport de Laval for approving the risqué designs; to CBS Outdoor and MetroMedia Plus for your impeccable service ; and to Dr. Alain Sotto, a true trailblazer in the world of workplace colon cancer prevention and screening programs (cant wait to tell you more about the work hes done for the TTC!). After the cut, see some pics of our media events in each city and just a glimpse of the press we got!. MONTREAL. ...
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Potent Cancer Fighter. (How does Cauliflower fight cancer? Within minutes of being eaten, sulforaphane enters the bloodstream and turbocharges the bodys antioxidant defense systems. When it reaches the cells, it activates phase-2 detoxification enzymes in the liver, which then "disarm" carinogenic molecules and help remove them from the cells.)[1] ...
Diindoylmethane is a molecule which is named after its structure, two indole groups attached to a methane group. It is commonly found in broccoli, and holds promise as being a molecule for anti-cancer effects and as an aromatase inhibitor.
Breast cancer is a wide-spread condition. Many know about its treatments, but not as much is known about prevention. Learn more here...
Biomarkers in cancer prevention are increasingly important tools in primary prevention and in intervention by chemopreventive agents. Biomarkers can be utilized as indicators of exposures, effects and individual susceptibility to cancer. Sampling of
Learn more about Indole-3-Carbinol at Largo Medical Center Supplement Forms/Alternate Names : I3C Uses Principal Proposed Uses Cancer...
Learn more about Indole-3-Carbinol at Aventura Hospital & Medical Center Supplement Forms/Alternate Names : I3C Uses Principal Proposed Uses ...
MEP Christel Schaldemose hosted an inter-party meeting of MEPs on 7 January to discuss cancer prevention through better regulation of hormone (...)
Learn more about Cancer Prevention (Reducing the Risk) at Grand Strand Medical Center Uses Principal Proposed Natural Treatments Folate ...
Cancer patient fact sheets providing information about various cancers, making patients better informed. Also offering potential cancer prevention based on research.
Adult T-cell leukemia/lymphoma (ATLL) is a malignancy derived from T cells infected with human T-cell leukemia virus type 1 (HTLV-1), and it is known to be resistant to standard anticancer therapies. Indole-3-carbinol (I3C), a naturally occurring component of Brassica vegetables such as cabbage, broccoli and Brussels sprout, is a promising chemopreventive agent as it is reported to possess antimutagenic, antitumorigenic and antiestrogenic properties in experimental studies. The aim of this study was to determine the potential anti-ATLL effects of I3C both in vitro and in vivo. In the in vitro study, I3C inhibited cell viability of HTLV-1-infected T-cell lines and ATLL cells in a dose-dependent manner. Importantly, I3C did not exert any inhibitory effect on uninfected T-cell lines and normal peripheral blood mononuclear cells. I3C prevented the G1/S transition by reducing the expression of cyclin D1, cyclin D2, Cdk4 and Cdk6, and induced apoptosis by reducing the expression of XIAP, survivin and Bcl-2,
The green tea (Camellia sinensis) catechin, (-)-epigallocatechin-3-gallate (EGCG), has shown cancer-preventive activity in animal models. Previously, we have reported the bioavailability of EGCG in rats and mice. Here, we report that cotreatment of HT-29 human colon cancer cells with genistein (from soy) increased cytosolic EGCG by 2- to 5-fold compared with treatment with EGCG only. Inclusion of genistein, at non-cytotoxic concentrations, increased the growth inhibitory effects of EGCG against HT-29 cells (up to 2-fold at 20 μM genistein). Intragastric coadministration of EGCG (75 mg/kg) and genistein (200 mg/kg) to CF-1 mice resulted in an increase in plasma half-life (t1/2 148.7 ± 16.4 versus 111.5 ± 23.4 min) and exposure (AUC0→∞ 183.9 ± 20.2 versus 125.8 ± 26.4 μg/ml × min) of EGCG. Cotreatment with genistein also increased the maximal concentration (Cmax), 6 h exposure (AUC0→360 min), and t1/2 of EGCG in the small intestine by 2.0-, 4.7- and 1.4-fold, respectively, compared ...
Tea and coffee are the most commonly used beverages throughout the world. Both decoctions are rich in small organic molecules such as phenolics/polyphenolics, purine alkaloids, many methylxanthines, substituted benzoic and cinnamic acids. Many of these molecules are physiologically chemopreventive and chemoprotective agents against many severe conditions such as cancer, Alzheimer, Parkinsonism, inflammation, sleep apnea, cardiovascular disorders, bradycardia, fatigue, muscular relaxation, and oxidative stress. Caffeine, a purine alkaloid, is a common metabolite of both tea and coffee aqueous decoctions and its concentration in tea/coffee depends on the fermentation process, preparation of the water extract and quality of tea leaves/coffee beans. A 250 ml of a coffee cup contains 100-150 mg caffeine while the same volume of strong tea contains 25-40 mg caffeine.  The present paper presents the potential of caffeine as a potent chemopreventive agent that can be used for numerous physiological
A myriad of medicinal effects has been attributed to Thymoquinone (TQ), the major biological-active component of Nigella sativa. TQ has been shown to exhibit potent anti-tumor activities. The present work was undertaken to further explore TQs chemopreventive efficacy against 1, 2-dimethylhydrazine (DMH)-induced colon carcinogenesis in the rat model through a two-phase study (initiation and post-initiation) and to evaluate its potential impact on tumor progression and invasion in vivo. TQ treatment in the initiation phase significantly reduced tumor incidence, multiplicity and mean tumor volume. However, although mean tumor volume and multiplicity were decreased upon TQ treatment in the post-initiation phase, TQ did not reduce incidence significantly. Cellular proliferation, as assessed by expression of colonic PCNA, was shown to be inhibited in consequence to TQ treatment in both phases, with a more pronounced reduction in the initiation phase. In addition, our results demonstrated an appreciable
Background/Purpose Acyclic retinoid (ACR) is a promising chemopreventive agent for hepatocellular carcinoma (HCC) that selectively inhibits the growth of HCC cells (JHH7) but not normal hepatic cells (Hc). To better understand the molecular basis of the selective anti-cancer effect of ACR, we performed nuclear magnetic resonance (NMR)-based and capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS)-based metabolome analyses in JHH7 and Hc cells after treatment with ACR. Methodology/Principal Findings NMR-based metabolomics revealed a distinct metabolomic profile of JHH7 cells at 18 h after ACR treatment but not at 4 h after ACR treatment. CE-TOFMS analysis identified 88 principal metabolites in JHH7 and Hc cells after 24 h of treatment with ethanol (EtOH) or ACR. The abundance of 71 of these metabolites was significantly different between EtOH-treated control JHH7 and Hc cells, and 49 of these metabolites were significantly down-regulated in the ACR-treated JHH7 cells compared to the
Green tea is a popular drink consumed daily by millions of people around the world. Previous studies have shown that some polyphenol compounds from green tea possess anticancer activities. However, systemic evaluation was limited. In this study, we determined the cancer chemopreventive potentials of 10 representative polyphenols (caffeic acid, CA; gallic acid, GA; catechin, C; epicatechin, EC; gallocatechin, GC; catechin gallate, CG; gallocatechin gallate, GCG; epicatechin gallate, ECG; epigallocatechin, EGC; and epigallocatechin gallate, EGCG), and explored their structure-activity relationship. The effect of the 10 polyphenol compounds on the proliferation of HCT-116 and SW-480 human colorectal cancer cells was evaluated using an MTS assay. Cell cycle distribution and apoptotic effects were analyzed by flow cytometry after staining with propidium iodide (PI)/RNase or annexin V/PI. Among the 10 polyphenols, EGCG showed the most potent antiproliferative effects, and significantly induced cell cycle
Cruciferous vegetables, such as broccoli, cabbage and kale, are rich sources of sulfur-containing compounds called glucosinolates. Isothiocyanates are biologically active hydrolysis (breakdown) products of glucosinolates. Cruciferous vegetables contain a variety of different glucosinolates, each of which forms a different isothiocyanate when hydrolyzed (see Figure) (1). For example, broccoli is a good source of glucoraphanin, the glucosinolate precursor of sulforaphane (SFN), and sinigrin, the glucosinolate precursor of allyl isothiocyanate (AITC) (2). Watercress is a rich source of gluconasturtiin, the precursor of phenethyl isothiocyanate (PEITC), while garden cress is rich in glucotropaeolin, the precursor of benzyl isothiocyanate (BITC). At present, scientists are interested in the cancer-preventive activities of vegetables that are rich in glucosinolates (see Cruciferous Vegetables), as well as individual isothiocyanates (3).. Summary. * Isothiocyanates are derived from the hydrolysis ...
Regarding vitamins, vitamin C has had limited study, but with the data available there is no evidence of a protective effect. Vitamin E is a naturally occurring fat-soluble vitamin found predominantly in plant foods and some animal foods. In a supplementation trial, there was suggestion that vitamin E was of benefit, but all the participants were smokers. Two other publications failed to show a benefit, and a preliminary report from the selenium and vitamin E trial does not suggest a benefit. As for allium vegetables which include garlic, onions, leeks, chives, scallions and shallots, while in vitro data suggest a protective benefit, population based studies are limited and a protective effect remains to be determined. Finally, cruciferous vegetables include broccoli, cauliflower Brussels sprouts, cabbage, bok choy, collard greens and kale. These are rich in sulforaphane and indole-3 carbinol, which have anticarcinogenic properties. To date, population-based studies are limited and a positive ...
Department of Dermatology, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA. Epidemiological, in vitro cell culture, and in vivo animal studies have shown that green tea or its constituent polyphenols, particularly its major polyphenol epigallocatechin-3-gallate (EGCG) may protect against many cancer types. In earlier studies, we showed that green tea polyphenol EGCG causes a G0/G1-phase cell cycle arrest and apoptosis of human epidermoid carcinoma (A431) cells. We also demonstrated that these effects of EGCG may be mediated through the inhibition of nuclear factor kappa B that has been associated with cell cycle regulation and cancer. In this study, employing A431 cells, we provide evidence for the involvement of cyclin kinase inhibitor (cki)-cyclin-cyclin-dependent kinase (cdk) machinery during cell cycle deregulation by EGCG. As shown by immunoblot analysis, EGCG treatment of the cells resulted in significant dose- and time-dependent (i) upregulation of the ...

Panax Ginseng For Semen Volume - SemenRxSemenRxPanax Ginseng For Semen Volume - SemenRxSemenRx

Panax Ginseng should be avoided when taking aspirin, Warfarin/Coumadin, oral hypoglycemic agents, insulin, Phenelzine, ... be supported with reference to its anticarcinogenic and antioxidant properties. Some animal experiments to determine whether ...
more infohttp://www.semenrx.com/panax-ginseng-for-semen-volume/

Saffron | GreenMedInfo | Substance | Natural Medicine | AlternativeSaffron | GreenMedInfo | Substance | Natural Medicine | Alternative

Anticarcinogenic Agents Research. [x] Remove Focus on Anticarcinogenic Agents. Filter by Study Type. Animal Study. ...
more infohttp://www.greenmedinfo.com/substance/saffron?ed=5175

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti...Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti...

... of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin ... Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents.. *Oliver Werz, Jana Gerstmeier, Ulrike ... of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin ... Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) possesses anti-inflammatory and anti-carcinogenic properties in vivo, and ...
more infohttps://www.semanticscholar.org/paper/Potent-inhibition-of-human-5-lipoxygenase-and-E%E2%82%82-by-Schaible-Traber/6c3012f4120c6813ed77a527eddbfb875091b7c2

Cancer chemoprevention with dietary phytochemicals.  - PubMed - NCBICancer chemoprevention with dietary phytochemicals. - PubMed - NCBI

Anticarcinogenic Agents. LinkOut - more resources. Full Text Sources. *Nature Publishing Group. Other Literature Sources. * ... Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently ... Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/14570043

Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti...Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti...

... of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin ... Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) possesses anti-inflammatory and anti-carcinogenic properties in vivo, and ...
more infohttps://insights.ovid.com/biopha/201308150/00075840-201308150-00004

Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. - Full Text View -...Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. - Full Text View -...

Protective Agents. Physiological Effects of Drugs. Antimutagenic Agents. Anticarcinogenic Agents. Antineoplastic Agents. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT01394796

A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor - Full Text View - ClinicalTrials.govA Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor - Full Text View - ClinicalTrials.gov

Anticarcinogenic Agents. Protective Agents. Physiological Effects of Drugs. Antineoplastic Agents. Protein Kinase Inhibitors. ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00001696

A Study of the Safety and Effects of ADH-1 Given Daily to Subjects With Solid Tumors - Full Text View - ClinicalTrials.govA Study of the Safety and Effects of ADH-1 Given Daily to Subjects With Solid Tumors - Full Text View - ClinicalTrials.gov

Anticarcinogenic Agents;. Antineoplastic Agents;. Cadherins. Additional relevant MeSH terms:. Layout table for MeSH terms. ... Dose Finding, Safety, Pharmacokinetic and Pharmacodynamic Study of the Vascular Targeting Agent Exherin™ (ADH-1) Administered ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00225550

Vegetables, fruit, and cancer prevention: a review.  - PubMed - NCBIVegetables, fruit, and cancer prevention: a review. - PubMed - NCBI

Anticarcinogenic Agents. LinkOut - more resources. Full Text Sources. *Elsevier Science. Other Literature Sources. *Cited by ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8841165?dopt=Abstract

Indole-3-Carbinol | GreenMedInfo | Substance | Natural MedicineIndole-3-Carbinol | GreenMedInfo | Substance | Natural Medicine

Pharmacological Actions : Angiogenesis Inhibitors, Anti-Estrogenic, Anti-Inflammatory Agents, Anticarcinogenic Agents, ... Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, NF-kappaB Inhibitor. Additional Keywords : ... Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic. Anti Therapeutic Actions : Assisted ... Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Cyclooxygenase 2 Inhibitors. Problem ...
more infohttps://www.greenmedinfo.com/substance/indole-3-carbinol

Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies.Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies.

Anticarcinogenic Agents / therapeutic use*. Breast Neoplasms / prevention & control. Colorectal Neoplasms / prevention & ... 0/Anticarcinogenic Agents; 0/Fatty Acids, Omega-3; 463-40-1/alpha-Linolenic Acid ...
more infohttp://www.biomedsearch.com/nih/Omega-3-fatty-acids-cancers/22591896.html

Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of...Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of...

... and suppression of gastric acidity with acid-reducing agents could impair their absorption. In addition, a maj ... Anticarcinogenic Agents / pharmacokinetics, therapeutic use*. Drug Interactions. Gastric Acid. Gastric Acidity Determination. ... Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of ... In addition, a majority of cancer patients frequently take acid-reducing agents to alleviate symptoms of gastroesophageal ...
more infohttp://www.biomedsearch.com/nih/Drug-Absorption-Interactions-Between-Oral/22739140.html

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

0 (Anticarcinogenic Agents); 0 (Phytoestrogens). [Em] M s de entrada:. 1709. [Cu] Atualiza o por classe:. 170911. ... 0 (Angiogenesis Inducing Agents); 0 (Estrogen Receptor beta); 0 (Iridoid Glucosides); 0 (Phytoestrogens); 0 (Platelet ... 0 (Antineoplastic Agents, Phytogenic); 0 (Butylene Glycols); 0 (Isoflavones); 0 (Lignans); 0 (Phytoestrogens); 6287WC5J2L ( ... involves the use of specific natural products or synthetic chemical agents to overturn, repress, or prevent pre-malignancy ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D27.505.696.399.472.277.540.500

MEDLINE - Resultado p gina 1
	MEDLINE - Resultado p gina 1

0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Anticarcinogenic Agents); 0 (Carcinogens); 87299V3Q9W (Azaserine); R16CO5Y76E ( ... Treatment of wild-type mice with O-GlcNAcylation-inducing agents reverses AMPK action. Finally, we demonstrate that AMPK ... Conversely, O-GlcNAcylation-inducing agents counteract the anti-hypertrophic effect of AMPK. In vivo, AMPK activation prevents ...
more infohttp://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&nextAction=lnk&base=MEDLINE&lang=p&format=detailed.pft&indexSearch=EX&exprSearch=D12.125.154.800.500

TNO Repository search for: subject:CocarcinogenesisTNO Repository search for: subject:'Cocarcinogenesis'

Nutrition · Animals · Anticarcinogenic Agents · Azaserine · Body Weight · Carcinogens · Cell Division · Cocarcinogenesis · ... Chemicals/CAS: Anticarcinogenic Agents; Azaserine, 115-02-6; Carcinogens; Dietary Fats, Unsaturated; Docosahexaenoic Acids, ... pyrene as the carcinogenic agent. These factors included severe tissue tissue damage induced by electro-coagulation, glass ...
more infohttps://repository.tudelft.nl/search/tno/?q=subject%3A%22Cocarcinogenesis%22

NIH VideoCast - When natural products meet cellular targets: A potential role of IGF-1 receptor in lycopene and docetaxel ...NIH VideoCast - When natural products meet cellular targets: A potential role of IGF-1 receptor in lycopene and docetaxel ...

Anticarcinogenic Agents--therapeutic use. Drug Therapy, Combination. Prostatic Neoplasms--drug therapy. Receptor, IGF Type 1-- ...
more infohttps://videocast.nih.gov/summary.asp?Live=9954

TNO Repository search for: subject:Pancreatic NeoplasmsTNO Repository search for: subject:'Pancreatic Neoplasms'

Nutrition · Animals · Anticarcinogenic Agents · Azaserine · Body Weight · Carcinogens · Combined Modality Therapy · Cricetinae ... Nutrition · Animals · Anticarcinogenic Agents · Azaserine · Body Weight · Carcinogens · Cell Division · Cocarcinogenesis · ... Chemicals/CAS: Anticarcinogenic Agents; Azaserine, 115-02-6; Carcinogens; Nitrosamines; nitrosobis(2-oxopropyl)amine, 60599-38- ... Chemicals/CAS: Anticarcinogenic Agents; Azaserine, 115-02-6; Carcinogens; Dietary Fats, Unsaturated; Docosahexaenoic Acids, ...
more infohttps://repository.tudelft.nl/search/tno/?q=subject:%22Pancreatic%20Neoplasms%22

Clove: Uses, Side Effects, Interactions, Dosage, and WarningClove: Uses, Side Effects, Interactions, Dosage, and Warning

Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View ... Int.J Antimicrob.Agents 1999;12(3):257-262. View abstract.. *Azuma, Y., Ozasa, N., Ueda, Y., and Takagi, N. Pharmacological ... Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract ...
more infohttps://www.webmd.com/vitamins/ai/ingredientmono-251/clove

Clavo de Olor: MedlinePlus suplementosClavo de Olor: MedlinePlus suplementos

Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View ... Int.J Antimicrob.Agents 1999;12:257-262. View abstract.. * Soetiarto, F. The relationship between habitual clove cigarette ... Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract ...
more infohttps://medlineplus.gov/spanish/druginfo/natural/251.html

Clove: MedlinePlus SupplementsClove: MedlinePlus Supplements

Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View ... Int.J Antimicrob.Agents 1999;12:257-262. View abstract.. * Soetiarto, F. The relationship between habitual clove cigarette ... Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract ...
more infohttps://medlineplus.gov/druginfo/natural/251.html

Nutritional and Toxicological Aspects of Food Safety | SpringerLinkNutritional and Toxicological Aspects of Food Safety | SpringerLink

Naturally Occurring Phenolics as Antimutagenic and Anticarcinogenic Agents Hans F. Stich, Miriam P. Rosin ...
more infohttps://link.springer.com/book/10.1007%2F978-1-4684-4790-3

HCPCS Codes - HCPCS Level II Coding - AAPCHCPCS Codes - HCPCS Level II Coding - AAPC

CPT® codes (did): 51720 (Bladder instillation of anticarcinogenic agent (including retention time)) ...
more infohttps://www.aapc.com/resources/medical-coding/hcpcs.aspx

Preferential inhibition of bacterial elastase over human neutrophil elastase by leaf extracts of Psidium guajava: an in vitro...Preferential inhibition of bacterial elastase over human neutrophil elastase by leaf extracts of Psidium guajava: an in vitro...

The Bowman-Birk Inhibitor from soybeans as an anticarcinogenic agent. Am J Clin Nutr1. 1998;68:14068-123. [12.] Hejgaard J. ... Plant product as antimicrobial agents. Clin Microbial Rev. 1999;12:564-82. [7.] Hsieh CL, Huang CN, Lin YC, Peng RY. Molecular ... Anti-elastase and anti-hyaluronidase activity of phenolic substances from Areca catechu as a new antiageing agent. Int J Cosmet ... Chemopreventive agents: protease inhibitors. Pharmacol Ther. 1998;78:167-209. [11.] Kennedy AR. ...
more infohttps://www.thefreelibrary.com/Preferential+inhibition+of+bacterial+elastase+over+human+neutrophil+...-a0468141937

Optimization of the Extraction of Total Phenolic Compounds from Sunflower Meal and Evaluation of the Bioactivities of Chosen...Optimization of the Extraction of Total Phenolic Compounds from Sunflower Meal and Evaluation of the Bioactivities of Chosen...

All chosen extracts showed potential as antimicrobial and anticarcinogenic agents. In conclusion the CGA extract was ... Anticarcinogenic activity of chosen phenolic extracts: This evaluation was carried out in the National Cancer Institute, ... Plant products as antimicrobial agents. Clin. Microbiol. Rev., 12: 564-582.. PubMed , Direct Link , Dai, J. and R.J. Mumper, ... Anticarcinogenic activity of 80% acetone, methanol and ethanol sunflower meal extracts on several cell line carcinomas. HEPG2: ...
more infohttp://scialert.net/fulltext/?doi=ajft.2011.1002.1020&org=10
  • Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals. (nih.gov)
  • This article is a review of the available clinical literature describing the extent of the interaction between 15 orally administered, small-molecule targeted anticancer therapies and acid-reducing agents. (biomedsearch.com)
  • Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. (nih.gov)
  • A number of agents have been discovered and developed that aim to inhibit angiogenesis and to convert the tumor to a dormant state. (tudelft.nl)