Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
A low-molecular-weight protein (minimum molecular weight 8000) which has the ability to inhibit trypsin as well as chymotrypsin at independent binding sites. It is characterized by a high cystine content and the absence of glycine.
Organic compounds with the general formula R-NCS.
Mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals.
7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
One of the Liliaceae used as a spice (SPICES) and traditional remedy. It contains alliin lyase and alliin, which is converted by alliin lyase to allicin, the pungent ingredient responsible for the aroma of fresh cut garlic.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
An araliaceous genus of plants that contains a number of pharmacologically active agents used as stimulants, sedatives, and tonics, especially in traditional medicine. Sometimes confused with Siberian ginseng (ELEUTHEROCOCCUS).
A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
A di-tert-butyl PHENOL with antioxidant properties.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Use of plants or herbs to treat diseases or to alleviate pain.
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
A plant species of the family CUCURBITACEAE. It is a source of ribosome-inactivating proteins and triterpene glycosides.
A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.
The infusion of leaves of CAMELLIA SINENSIS (formerly Thea sinensis) as a beverage, the familiar Asian tea, which contains CATECHIN (especially epigallocatechin gallate) and CAFFEINE.
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.
Organic derivatives of thiocyanic acid which contain the general formula R-SCN.
A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.
A plant genus of the family LAMIACEAE that is an ingredient of Banxia Houpu (DRUGS, CHINESE HERBAL).
A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.
Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.
Regular course of eating and drinking adopted by a person or animal.
A plant genus of the family Cruciferae. It contains many species and cultivars used as food including cabbage, cauliflower, broccoli, Brussel sprouts, kale, collard greens, MUSTARD PLANT; (B. alba, B. junica, and B. nigra), turnips (BRASSICA NAPUS) and rapeseed (BRASSICA RAPA).
A class of phenolic acids related to chlorogenic acid, p-coumaric acid, vanillic acid, etc., which are found in plant tissues. It is involved in plant growth regulation.
Substituted thioglucosides. They are found in rapeseed (Brassica campestris) products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
The use of chemical compounds to prevent the development of a specific disease.
Serine proteinase inhibitors which inhibit trypsin. They may be endogenous or exogenous compounds.
Experimentally induced tumors of the LIVER.
An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.
A collective term for a group of around nine geometric and positional isomers of LINOLEIC ACID in which the trans/cis double bonds are conjugated, where double bonds alternate with single bonds.
An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.
Tumors or cancer of the COLON.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
A class of compounds composed of repeating 5-carbon units of HEMITERPENES.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
A group of phenyl benzopyrans named for having structures like FLAVONES.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
3-Phenylchromones. Isomeric form of FLAVONOIDS in which the benzene group is attached to the 3 position of the benzopyran ring instead of the 2 position.
Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Organic compounds that contain 1,2-diphenylethylene as a functional group.
A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin.
Eighteen-carbon essential fatty acids that contain two double bonds.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
A large class of organic compounds having more than one PHENOL group.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The relationship between the dose of an administered drug and the response of the organism to the drug.
A food group comprised of EDIBLE PLANTS or their parts.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
A cell line derived from cultured tumor cells.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
The general name for a group of fat-soluble pigments found in green, yellow, and leafy vegetables, and yellow fruits. They are aliphatic hydrocarbons consisting of a polyisoprene backbone.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Tumors or cancer of the SKIN.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Tumors or cancer of the human BREAST.
Tumors or cancer of the LUNG.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. (1/2345)

The epidemiologic literature in the English language regarding intake of tomatoes and tomato-based products and blood lycopene (a compound derived predominantly from tomatoes) level in relation to the risk of various cancers was reviewed. Among 72 studies identified, 57 reported inverse associations between tomato intake or blood lycopene level and the risk of cancer at a defined anatomic site; 35 of these inverse associations were statistically significant. No study indicated that higher tomato consumption or blood lycopene level statistically significantly increased the risk of cancer at any of the investigated sites. About half of the relative risks for comparisons of high with low intakes or levels for tomatoes or lycopene were approximately 0.6 or lower. The evidence for a benefit was strongest for cancers of the prostate, lung, and stomach. Data were also suggestive of a benefit for cancers of the pancreas, colon and rectum, esophagus, oral cavity, breast, and cervix. Because the data are from observational studies, a cause-effect relationship cannot be established definitively. However, the consistency of the results across numerous studies in diverse populations, for case-control and prospective studies, and for dietary-based and blood-based investigations argues against bias or confounding as the explanation for these findings. Lycopene may account for or contribute to these benefits, but this possibility is not yet proven and requires further study. Numerous other potentially beneficial compounds are present in tomatoes, and, conceivably, complex interactions among multiple components may contribute to the anticancer properties of tomatoes. The consistently lower risk of cancer for a variety of anatomic sites that is associated with higher consumption of tomatoes and tomato-based products adds further support for current dietary recommendations to increase fruit and vegetable consumption.  (+info)

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. (2/2345)

BACKGROUND: Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of foods contaminated with aflatoxins, which require metabolic activation to become carcinogenic. In a randomized, placebo-controlled, double-blind phase IIa chemoprevention trial, we tested oltipraz, an antischistosomal drug that has been shown to be a potent and effective inhibitor of aflatoxin-induced hepatocarcinogenesis in animal models. METHODS: In 1995, 234 adults from Qidong were enrolled. Healthy eligible individuals were randomly assigned to receive by mouth 125 mg oltipraz daily, 500 mg oltipraz weekly, or a placebo. Sequential immunoaffinity chromatography and liquid chromatography coupled to mass spectrometry or to fluorescence detection were used to identify and quantify phase 1 and phase 2 metabolites of aflatoxin B1 in the urine of study participants. Reported P values are two-sided. RESULTS: One month of weekly administration of 500 mg oltipraz led to a 51% decrease in median levels of the phase 1 metabolite aflatoxin M1 excreted in urine compared with administration of a placebo (P = .030), but it had no effect on levels of a phase 2 metabolite, aflatoxin-mercapturic acid (P = .871). By contrast, daily intervention with 125 mg oltipraz led to a 2.6-fold increase in median aflatoxin-mercapturic acid excretion (P = .017) but had no effect on excreted aflatoxin M1 levels (P = .682). CONCLUSIONS: Intermittent, high-dose oltipraz inhibited phase 1 activation of aflatoxins, and sustained low-dose oltipraz increased phase 2 conjugation of aflatoxin, yielding higher levels of aflatoxin-mercapturic acid. While both mechanisms can contribute to protection, this study highlights the feasibility of inducing phase 2 enzymes as a chemopreventive strategy in humans.  (+info)

Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. (3/2345)

BACKGROUND: Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory effects on the growth and invasive properties of human mammary cancer cells in vitro; furthermore, the two agents have displayed additive effects in vitro. In this study, we examined whether tangeretin would enhance tamoxifen's therapeutic benefit in vivo. METHODS: Female nude mice (n = 80) were inoculated subcutaneously with human MCF-7/6 mammary adenocarcinoma cells. Groups of 20 mice were treated orally by adding the following substances to their drinking water: tamoxifen (3 x 10(-5) M), tangeretin (1 x 10(-4) M), tamoxifen plus tangeretin (3 x 10(-5) M plus 1 x 10(-4) M), or solvent. RESULTS AND CONCLUSIONS: Oral treatment of mice with tamoxifen resulted in a statistically significant inhibition of tumor growth compared with solvent treatment (two-sided P = .001). Treatment with tangeretin did not inhibit tumor growth, and addition of this compound to drinking water with tamoxifen completely neutralized tamoxifen's inhibitory effect. The median survival time of tumor-bearing mice treated with tamoxifen plus tangeretin was reduced in comparison with that of mice treated with tamoxifen alone (14 versus 56 weeks; two-sided P = .002). Tangeretin (1 x 10(-6) M or higher) inhibited the cytolytic effect of murine natural killer cells on MCF-7/6 cells in vitro, which may explain why tamoxifen-induced inhibition of tumor growth in mice is abolished when tangeretin is present in drinking water. IMPLICATIONS: We describe an in vivo model to study potential interference of dietary compounds, such as flavonoids, with tamoxifen, which could lead to reduced efficacy of adjuvant therapy. In our study, the tumor growth-inhibiting effect of oral tamoxifen was reversed upon addition of tangeretin to the diet. Our data argue against excessive consumption of tangeretin-added products and supplements by patients with mammary cancer during tamoxifen treatment.  (+info)

Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. (4/2345)

BACKGROUND: Retinoids (derivatives of vitamin A) are reported to reduce the occurrence of some second primary cancers, including aerodigestive tract tumors. In contrast, beta-carotene does not reduce the occurrence of primary aerodigestive tract cancers. Mechanisms explaining these effective retinoid and ineffective carotenoid chemoprevention results are poorly defined. Recently, the all-trans-retinoic acid (RA)-induced proteolysis of cyclin D1 that leads to the arrest of cells in G1 phase of the cell cycle was described in human bronchial epithelial cells and is a promising candidate for such a mechanism. In this study, we have investigated this proteolysis as a common signal used by carotenoids or receptor-selective and receptor-nonselective retinoids. METHODS: We treated cultured normal human bronchial epithelial cells, immortalized human bronchial epithelial cells (BEAS-2B), and transformed human bronchial epithelial cells (BEAS-2BNNK) with receptor-selective or receptor-nonselective retinoids or with carotenoids and studied the effects on cell proliferation by means of tritiated thymidine incorporation and on cyclin D1 expression by means of immunoblot analysis. We also examined whether calpain inhibitor I, an inhibitor of the 26S proteasome degradation pathway, affected the decline (i.e., proteolysis) of cyclin D1. RESULTS: Receptor-nonselective retinoids were superior to the carotenoids studied in mediating the decline in cyclin D1 expression and in suppressing the growth of bronchial epithelial cells. Retinoids that activated retinoic acid receptor beta or retinoid X receptor pathways preferentially led to a decrease in the amount of cyclin D1 protein and a corresponding decline in growth. The retinoid-mediated degradation of cyclin D1 was blocked by cotreatment with calpain inhibitor I. CONCLUSIONS: Retinoid-dependent cyclin D1 proteolysis is a common chemoprevention signal in normal and neoplastic human bronchial epithelial cells. In contrast, carotenoids did not affect cyclin D1 expression. Thus, the degradation of cyclin D1 is a candidate intermediate marker for effective retinoid-mediated cancer chemoprevention in the aerodigestive tract.  (+info)

Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy. (5/2345)

Full term pregnancy early in life is the most effective natural protection against breast cancer in women. Rats treated with chemical carcinogen are similarly protected by a previous pregnancy from mammary carcinogenesis. Proliferation and differentiation of the mammary gland does not explain this phenomenon, as shown by the relative ineffectiveness of perphenazine, a potent mitogenic and differentiating agent. Here, we show that short term treatment of nulliparous rats with pregnancy levels of estradiol 17beta and progesterone has high efficacy in protecting them from chemical carcinogen induced mammary cancers. Because the mammary gland is exposed to the highest physiological concentrations of estradiol and progesterone during full term pregnancy, it is these elevated levels of hormones that likely induce protection from mammary cancer. Thus, it appears possible to mimic the protective effects of pregnancy against breast cancer in nulliparous rats by short term specific hormonal intervention.  (+info)

Inhibition of aberrant proliferation and induction of apoptosis in HER-2/neu oncogene transformed human mammary epithelial cells by N-(4-hydroxyphenyl)retinamide. (6/2345)

Epithelial cells from non-cancerous mammary tissue in response to exposure to chemical carcinogens or transfection with oncogenes exhibit hyperproliferation and hyperplasia prior to the development of cancer. Aberrant proliferation may, therefore, represent a modifiable early occurring preneoplastic event that is susceptible to chemoprevention of carcinogenesis. The synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR), has exhibited preventive efficacy in several in vitro and in vivo breast cancer models, and represents a promising chemopreventive compound for clinical trials. Clinically relevant biochemical and cellular mechanisms responsible for the chemopreventive effects of HPR, however, are not fully understood. Experiments were performed on preneoplastic human mammary epithelial 184-B5/HER cells derived from reduction mammoplasty and initiated for tumorigenic transformation by overexpression of HER-2/neu oncogene, to examine whether HPR inhibits aberrant proliferation of these cells and to identify the possible mechanism(s) responsible for the inhibitory effects of HPR. Continuous 7-day treatment with HPR produced a dose-dependent, reversible growth inhibition. Long-term (21 day) treatment of 184-B5/HER cells with HPR inhibited anchorage-dependent colony formation by approximately 80% (P < 0.01) relative to that observed in the solvent control. A 24 h treatment with cytostatic 400 nM HPR produced a 25% increase (P = 0.01) in G0/G1 phase, and a 36% decrease (P = 0.01) in S phase of the cell cycle. HPR treatment also induced a 10-fold increase (P = 0.02) in the sub-G0 (apoptotic) peak that was down-regulated in the presence of the antioxidant N-acetyl-L-cysteine. Treatment with HPR resulted in a 30% reduction of cellular immunoreactivity to tyrosine kinase, whereas immunoreactivity to p185HER remained essentially unaltered. HPR exposure resulted in time-dependent increase in cellular metabolism of the retinoid as evidenced by increased formation of the inert metabolite N-(4-methoxyphenyl)-retinamide (MPR) and progressive increase in apoptosis. Thus, HPR-induced inhibition of aberrant proliferation may be caused, in part, by its ability to inhibit HER-2/neu-mediated proliferative signal transduction, retard cell cycle progression and upregulate cellular apoptosis.  (+info)

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. (7/2345)

Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for the prevention of cancer. However, the mechanism of the anti-carcinogenic activity of resveratrol is not well understood. Here we offer a possible explanation of its anti-cancer effect. Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis.  (+info)

Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (8/2345)

We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis.  (+info)

Full Text CA-97-014 PIVOTAL CLINICAL TRIALS FOR CHEMOPREVENTION AGENT DEVELOPMENT NIH GUIDE, Volume 26, Number 7, March 7, 1997 RFA: CA-97-014 P.T. 34 Keywords: Cancer/Carcinogenesis Clinical Trial Chemopreventive Agents National Cancer Institute Letter of Intent Receipt Date: April 3, 1997 Application Receipt Date: May 22, 1997 PURPOSE The Division of Cancer Prevention and Control (DCPC), National Cancer Institute (NCI) invites applications to further the drug development efforts of the Chemoprevention Branch by carrying out intermediate-sized Phase II/III efficacy trials of promising chemopreventive agents in major cancer target organs, particularly prostate, breast, lung, colon, and bladder. Currently, most NCI-sponsored Phase II clinical trials enroll fewer than 100 participants and evaluate a spectrum of potential SEBs as study endpoints over a relatively brief study period (2 weeks 6 months). This is in contrast to the large Phase III clinical chemoprevention trials with tamoxifen, ...
A polymer scale preventive agent for use in the polymerization of a monomer containing an ethylenic double bond is provided. The agent includes (A) a condensation reaction product obtained by reacting an aldehyde compound and a hydroxynaphthalene-based compound in the presence of a reducing agent, and (B) a polymer compound containing a nitrogen atom. This agent is capable of forming a coating with satisfactory scale prevention properties on inner wall surfaces of a polymerization vessel with a single-stage application, enabling the production process time to be shortened and the productivity and quality of polymeric products improved.
Are milk polyamines preventive agents against food allergy? - Volume 59 Issue 1 - Guy Dandrifosse, O. Peulen, N. El Khefif, P. Deloyer, A. C. Dandrifosse, Ch. Grandfils
3,3-Diindolylmethane (DIM) is a naturally occurring indole, which is currently under investigation as a potential chemopreventive agent. The concentrations of DIM in plasma, liver, kidney, lung, heart, and brain tissues were determined following oral administration of two different formulations to mice (250 mg/kg). Mice were sacrificed periodically from 0 to 24 h after administration of either a crystalline or an absorption-enhanced formulation (Bio-Response-DIM; Indolplex) of DIM, and plasma and tissue concentrations were determined by high-performance liquid chromatography (UV detection, 280 nm). A physiologically based pharmacokinetic (PBPK) model was developed to characterize the pharmacokinetic properties of the two different formulations. The final model included parameters reflecting linear first-order absorption, systemic clearance, and distributional clearance in the remainder compartment, which were considered independent of formulation. All pharmacokinetic profiles from the two ...
DIM (3,3-diindolylmethane), a small molecule compound, is a proposed cancer preventive agent that can be safely administered to humans in repeated doses. We report that administration of DIM in a multidose schedule protected rodents against lethal doses of total body irradiation up to 13 Gy, whethe …
Trials are being conducted to determine the authenticity of consuming Indole-3-Carbinol supplements to prevent illnesses, particularly cancer. Although it does not provide an active cure to cancer, Indole-3-Carbinol is scientifically proven to support the health of reproductive organs and cellular reproduction for both men and women. It also assists in detoxifying the intestines and liver.As an antioxidant, it stimulates the production of enzymes that detoxify toxins and protects cell structures including DNA. Lycopene is another vegetable antioxidant with proven health benefits.With possible anti-carcinogenic, antioxidant and anti-atherogenic effects, this vegetable component is only just being acknowledged as a solution to a variety of health issues Indole-3-Carbinol is currently being clinically researched as a cancer preventive agent by the National Institutes of Health.. Other names for Indole-3-Carbinol:. I3C, 3-Indolylcarbinol, 1H-Indole-3-methanol, 3-Hydroxymethyl Indole, 3 Hydroxymethyl ...
A number of possible preventive agents for cancers in different organs have been reported, however, little information is available regarding the effective agents for the development of gastric cancers. The rice components are known to be effective for the prevention of the development of cancers. Our group has demonstrated that fermented brown rice by Aspergillus Orzae (FBRA) has chemopreventive potentials in several organs. In this study, we investigated the modifying effects of FBRA exposed during the initiation or post-initiation phase of N-methyl-N-nitro-N-nitrosoguanidine (MNNG)-induced gastric carcinogenesis in rats. Five-week-old male ACI rats were divided into 7 groups. Groups 1-5 were given oral administration of MNNG (100 mg/l in distilled water) for 24 weeks starting at 6 weeks of age. Groups 2 and 3 were fed a diet containing 5 and 10% FBRA during the initiation phase, respectively, whereas groups 4 and 5 were fed these diets during the post-initiation phase. Group 6 was given a ...
3825 The isothiocyanate sulforaphane (SF) has received increasing interest of late as a promising chemopreventive agent in several model systems. As a natural product derived from cruciferous vegetables, SF has low toxicity, yet is able to regulate many factors important in tumorigenesis, including inflammation, cell cycle and apoptosis. Our current work is focused on determining whether SF is a good candidate for chemoprevention of UV-induced non-melanoma skin cancer (NMSC). Although there have been two published studies using SF in long-term mouse tumorigenesis experiments, the issue of whether SF can protect against NMSC when used concurrently with UVB treatment has not been addressed. We have therefore treated female SKH-1 hairless immunocompetant mice, 20 per group, with either UVB alone, UVB+Acetone, UVB+1μmol SF or UVB+2.5μmol SF. Mice were treated topically three times a week with either vehicle or SF, one hour prior to treatment with UVB. The UVB dosage started at 0.9 kJ/m2 and ...
Despite the intensive efforts and substantial advances that have occurred through focusing on improving treatment, cancer is still a leading cause of death worldwide. Many have argued that this could be avoided by focusing on cancer prevention, which has now entered the arena of targeted therapies. During the process of identifying preventive agents, dietary phytochemicals have emerged as modulators of key cellular pathways. By molecular modeling of the interactions of targeted proteins with these chemopreventive agents, we have provided knowledge for a better understanding of how these preventive agents work. Such knowledge will help the translation to new clinical practice of preventive medicine.. Citation Information: Cancer Prev Res 2011;4(10 Suppl):CN07-02. ...
Introduction: Chronic inflammation is widely recognized as an underlying etiological factor in carcinogenesis; there is enough evidence to support the use of non‐steroidal anti‐inflammatory drugs (NSAIDs), and more importantly, their chemically‐modified NO‐releasing prodrugs (NO‐NSAIDs) as promising chemopreventive agents. Metabolic activation of organic nitrate‐containing NO‐aspirins may lead to a cytotoxic activated linker (a quinone methide), raising safety concerns. Replacement of organic nitrates with N‐diazeniumdiolates as a second‐generation NONO‐NSAIDs allowed us to conduct a head‐to‐head comparison between NCX‐4016 (NO‐aspirin), CVM‐01 (NONO‐aspirin), and aspirin as analgesic, anti‐inflammatory, and anti‐pyretic agents with no significant gastrointestinal toxicity.. Methods: a) Anti‐inflammatory: paw edema induced by intraplantar injection of 100 µL of 1% carrageenan, paw volumes measured up to the tibiotarsal joint immediately prior to ...
Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P , 0.05) and increased lung hyperplastic lesions by 2.4-fold (P , 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.. ...
It has been demonstrated and confirmed that certain nonsteroidal anti-inflammatory drugs which inhibit cyclooxygenase and the synthesis of prostaglandins and other eicosanoids, can reduce the formation of both colon polyps and cancers in experimental animals given known carcinogens. Additionally, the results of several epidemiologic studies have suggested that nonsteroidal anti-inflammatory drugs may reduce the risk of colon polyp occurrence and/or colon cancer mortality. We have carried out a study to evaluate the methodology of the measurement of prostaglandin E2 (PGE2) in human colonic mucosa because its concentration may serve as a valuable intermediate marker of the pharmacological activity in Phase II studies of nonsteroidal anti-inflammatory drugs as colon cancer preventive agents. We studied all aspects of the actual measurement of PGE2 including the extraction efficiency of the PGE2 from the mucosa, the precision of the assay and calculation of the PGE2 content in terms of milligrams of ...
Antiangiogenics have shown to be effective and safe anticancer agents in preclinical animal tumor models but have had mixed results in clinical trials with advanced disease. One possible explanation for the lack of efficacy in these clinical trials could be due to the bulky size of tumors in patients with stage III/IV disease. In theory, antiangiogenics would be predicted to be more effective in preventing smaller avascular tumors from activating the angiogenic switch and thus would be an ideal class of compounds for use in a chemopreventative setting. TM is a potent antiangiogenic compound that has completed numerous phase I/II trials for solid tumors. Results from these clinical trials showed that TM is very well tolerated with minimal adverse effects (6, 11-15). The attractive safety profile of TM suggests that it may be amendable to long-term use and thus be developed as a chemopreventative agent.. Recent work from our laboratory showed that TM significantly retards the development of ...
Sigma-Aldrich offers abstracts and full-text articles by [Srilatha Badaboina, Hyoung-Woo Bai, Yun Hee Na, Chul-Hong Park, Tae Hoon Kim, Tae-Hoon Lee, Byung Yeoup Chung].
The overall hypothesis is that the combination of a low dose of the antiestrogen Raloxifene with omega-3 fatty acids will exert a synergistic breast cancer chemopreventive effect due to the crosstalk of their downstream cellular effects leading to decreased proliferation and increased apoptosis of premalignant mammary cells. Based on the investigators hypothesis that upregulation of functional estrogen receptors in the premalignant lesions is also responsible for the development of hormone independent tumors, the investigators postulate that the combination of antiestrogens and omega-3 fatty acids will reduce the development of both hormone-dependent and -independent tumors. At present, there are no known interventions able to decrease the development of hormone-independent tumors, which are more prevalent, more aggressive, leading to the patients demise. In addition, the investigators postulate that this approach will be safe since it will combine a lower and hence a less toxic dose of ...
Principal Investigator:KAWANISHI Shosuke, Project Period (FY):2001 - 2003, Research Category:Grant-in-Aid for Scientific Research (B), Section:展開研究, Research Field:Hygiene
The study, conducted by researchers at the Mayo Clinic College of Medicine in Scottsdale, Ariz., suggests this drug one day might be used to prevent and even treat breast tumors. Celebrex, marketed by Pfizer Inc., is a member of the general family of drugs that target the COX-2, an enzyme that plays a major role in arthritis pain and inflammation. This COX-2 inhibitor represents a strong option for treatment of breast cancers, and a preventative agent for treatment of individuals with high risk of developing breast cancer or disease relapse, said Pinku Mukherjee, Ph.D., the senior author of the report ...
Read chapter 6 Conclusions, Recommendations, and Future Directions: Despite increasing knowledge of human nutrition, the dietary contribution to cancer ...
Women have more options than ever for fighting breast cancer. But many arent getting the best screening and care, resulting in missed cancers, over-aggressive...
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Approximately 1 in 8 women in the U.S. will develop breast cancer in their lifetime. But not every womans chances of developing the disease are the same, and those with more risk factors might benefit from taking chemoprevention agents.. Chemoprevention agents are drugs that can inhibit or slow the growth of cancer cells. For some women who dont currently have breast cancer, taking medications like tamoxifen, raloxifene, or aromatase inhibitors can help reduce their odds for getting some types of the disease in the future, according to new recommendations from the U.S. Preventive Services Task Force (USPSTF).. Heres some more information about these recommendations and how you and your doctor can decide whether these medications are right for you.. ...
Effects of chemopreventive agents on the incidence of recurrent colorectal adenomas: a systematic review with network meta-analysis of randomized controlled trials Sajesh K Veettil,1 Nattawat Teerawattanapong,2 Siew Mooi Ching,3,4 Kean Ghee Lim,5 Surasak Saokaew,6–9 Pochamana Phisalprapa,10 Nathorn Chaiyakunapruk7,8,11,12 1School of Pharmacy/School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia; 2Division of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, Thailand; 3Department of Family Medicine, Faculty of Medicine and Health Sciences, 4Malaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang, 5Clinical School, Department of Surgery, International Medical University, Seremban, Negeri Sembilan, 6Center of Health Outcomes Research and Therapeutic Safety (Cohorts), School of Pharmaceutical Sciences, University of Phayao, Phayao, 7School of Pharmacy, Monash University Malaysia, Selangor,
Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, Cancer chemoprevention, chemical carcinogenesis, cytochrome P450, gluconasturtiin, glucosinolates, isothiocyanates, CRUCIFEROUS VEGETABLE CONSUMPTION, GLUTATHIONE-S-TRANSFERASE, DNA ADDUCT FORMATION, PHASE-II ENZYMES, EPIC-HEIDELBERG COHORT, ACETYL-L-CYSTEINE, A/J MOUSE LUNG, BENZYL ISOTHIOCYANATE, F344 RATS, BRUSSELS-SPROUTS ...
Research in my laboratory focuses on understanding the molecular mechanisms of selenium in cancer chemoprevention and the role of reactive oxygen species in carcinogenesis. Selenium is an essential trance element for human health. Selenium deficiency is known to be linked to the risk of certain cancers. Recent clinical studies demonstrated that selenium is a promising chemopreventive agent for prostate and colon cancers. We are currently studying redox-mediated and epigenetic effects of selenium on cell cycle and apoptosis in human prostate cancer cells. We are interested in determining how selenium modulates intracellular redox state, DNA methylation, and histone protein modifications to regulate the expression of genes involved in protection against oxidative stress, tumor suppression, cell cycle, and apoptosis. We also study combinations of selenium with other dietary chemopreventive agents, DNA methylation inhibitors, and histone deacetylase inhibitors for maximizing cancer prevention and ...
TY - JOUR. T1 - Application of pharmacogenomics to dietary cancer chemoprevention. AU - Prawan, Auemduan. AU - Khor, Tin Oo. AU - Li, Wenge. AU - Kong, Ah Ng Tony. PY - 2007/9. Y1 - 2007/9. N2 - Many lines of evidence demonstrate that certain dietary phytochemicals have cancer chemopreventive effects. These dietary phytochemicals or chemo-preventive agents can suppress or block carcinogenesis by 1 enhancing the biotransformation enzymatic activities for efficient elimination of carcinogens or reactive oxidative or nitrosative species (ROS/RNS); 2 suppressing the growth/inflammatory signaling pathways involved in cancer cell proliferation; and 3 modulating phase II detoxifying/antioxidant enzymes, e.g. glutathione S-transferases (GST), NAD(P)H-quinone reductase 1 (NQO1), UDP-glueuronosyltransferases (UGT), and antioxidant enzymes such as gamma-glutamylcysteine synthetase (γ-GCS) and heme oxygenase 1 (HO1). Comparison of gene expression profiles among Nrf2 wild type and Nrf2 knockout mice showed ...
The studys results suggest that the benefits of tamoxifen to prevent cancer can sufficiently compensate for its side effects in post-menopausal women under age 55 years who have an increased risk of developing breast cancer.. Research has shown that tamoxifen can protect against breast cancer for years after treatment ends, but identifying the group of women who can most benefit from the drug as a cancer preventive agent, without experiencing serious side effects, is a challenge. Side effects of the drug can include pulmonary embolism, endometrial cancer, deep vein thrombosis, and cataracts, as well as hot flashes and early menopause.. To investigate those women who would benefit the most from taking tamoxifen as a cancer preventive drug, Peter Alperin, MD, of Archimedes Inc. in San Francisco, and his colleagues used a mathematical model to simulate a post-menopausal population under age 55 years in a virtual clinical trial comparing tamoxifen treatment with no treatment. The investigators ...
in which A is a hydrocarbon ring optionally be cross-linked with a lower alkylene or an oxygen atom; said lower alkylene and hydrocarbon ring may optionally be substituted by at least one alkyl; and p and q are independently 0, 1 or 2),G is N, CH or COH, and --Ar is an aromatic heterocyclic group, an aromatic hydrocarbon group, benzoyl, phenoxy, or phenylthio, orG is a carbon atom, and --Ar is biphenylmethylidene,where said aromatic heterocyclic group, aromatic hydrocarbon group, benzoyl, phenoxy or phenylthio, and biphenylmethylidene may optionally be substituted by at least one group selected from a lower alkyl, a lower alkoxy and a halogen atom},or an acid addition salt thereof.(2) The therapeutic/preventive agent for cognitive dysfunctions according to the above (1), which is a therapeutic agent for senile dementia.(3) A therapeutic/preventive agent for cognitive dysfunctions, which comprises as an active ingredient an imide derivative of the above formula [1], wherein --Ar is an aromatic ...
Colorectal cancer, breast cancer and skin cancer are commonly-reported cancer types in the U.S. Although radiation and chemotherapy are routinely used to treat cancer, they produce side effects in patients. Additionally, resistance to chemotherapeutic drugs has been noticed in cancers. Thus, there i …
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: In Utero Exposure to Bioactive Food Components and Mammary Cancer Risk PA-05-059. NCI
Phenethyl isothiocyanate (PEITC) is a particularly beneficial type of isothiocyanate that shows promise as a treatment for, and preventative of, cancer.
TY - JOUR. T1 - Cancer Chemoprotection by Oltipraz. T2 - Experimental and Clinical Considerations. AU - Helzlsouer, Kathy J.. AU - Kensler, Thomas W.. PY - 1993/9. Y1 - 1993/9. N2 - Oltipraz (4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione) is an antischistosomal drug presently under evaluation as a possible chemoprotective agent in humans. To date, oltipraz has proved effective as an inhibitor of carcinogenesis in experimental models for breast, bladder, liver, forestomach, colon, tracheal, lung, and skin cancer. Studies on the mechanisms of action of oltipraz indicate that it affects the metabolism and disposition of chemical carcinogens, principally through the induction of electrophile detoxication enzymes. While this feature is common to many different classes of both natural and synthetic experimental chemoprotectors (i.e., phenolic antioxidants, isothiocyanates, flavonoids, indoles, cinnamates, coumarins, terpenes, and others), oltipraz may offer the earliest and easiest prospect for ...
N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylenebis(methylene))-2-(aminomethyl)- pyridine: Anti-HIV Agent; a monomacrocyclic N-pyridinylmethylene cyclam; structure in first source
In recent years, naturally occurring antioxidant compounds present in the diet and beverages consumed by humans have gained considerable attention as cancer chemopreventive agents (1, 2, 3, 4, 5) . Resveratrol, a polyphenolic compound present in grapes, nuts, fruits, and red wine, is a potent antioxidant with anti-inflammatory and cancer-preventive properties (7 , 8 , 10, 11, 12, 13 , 33, 34, 35, 36, 37, 38, 39, 40, 41, 42) . In vitro as well as in vivo studies have suggested that resveratrol may impart chemopreventive effects against certain cancers including skin cancer (10, 11, 12, 13 , 33, 34, 35, 36, 37, 38, 39, 40, 41, 42) . The molecular mechanism(s) by which resveratrol imparts cancer chemopreventive properties is not well defined. The present study was designed to define the mechanism(s) of the antiproliferative effects of resveratrol because it may result in the design of novel approaches for the management of cancer. In this study, we investigated the involvement and mechanism of cell ...
Interest in potential cancer chemopreventive and therapeutic properties of dietary ingredients, which are generally more tolerable in the human body ( 15), has increased in recent years, especially for the cancers that usually do not respond well to currently available therapies ( 17). Therefore, it is not surprising that chemoprevention of colon cancer, the leading cancer-related death in Western countries, is becoming more attractive. One of the dietary ingredients that possess anti-inflammatory and/or antioxidant properties is curcumin. Epidemiologic data suggest that curcumin may be responsible for the lower colon cancer rate in India and Southeast Asia ( 39). Based on that and its long history of consumption without any adverse health effects, curcumin is considered to be a safe chemopreventative agent ( 15).. Although it was suggested previously that curcumin-induced apoptosis is mediated through the impairment of the ubiquitin-proteasome pathway ( 40), the exact mechanism was not fully ...
The role of vitamin E in the etiology and prevention of colon cancer is not clear. It is possible that various forms of vitamin E may act differently in colon tissue and may be effective chemopreventive agents. Previous reports of vitamin E and colon cancer have focused on alpha-tocopherol and have not considered other dietary forms of vitamin E. Data from a study of 1,993 cases and 2,410 controls ...
Not every woman should use these preventive agents, but we believe women who are at increased risk for breast cancer should be given the option, because in some cases the magnitude of the risk reduction is large. For some women, these therapies can reduce the risk of breast cancer by up to 50%, said Kala Visvanathan, MBBS, FRACP, MHS, Co-Chair of the Guideline Panel and Associate Professor of Epidemiology and Oncology at the Johns Hopkins Bloomberg School of Public Health and the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center.. Risks and Benefits of Therapy. The guideline provides new insight on the risks and benefits for tamoxifen and raloxifene use in postmenopausal women. The risk and benefit profile for both agents varies by age, race, level of breast cancer risk, and history of hysterectomy. The guideline emphasizes that women should discuss both the risks and benefits of these drugs with their doctors before deciding whether to take these drugs for prevention.. We now have a ...
Perhaps the best way to fight cancer is to prevent it from developing in the first place, and based on newly published research from investigators at the University of Wisconsin-Madison, nanoparticles may be able to make cancer chemoprevention a reality. Using nanoparticles made of a biocompatible polymer, the investigators were able to encapsulate a molecule isolated from green tea that triggers apoptosis and inhibits angiogenesis, two key biochemical events that could prevent cancer. Hasan Mukhtar, Ph.D., led the team that published its results in the journal Cancer Research. One of the chief issues in chemoprevention-the use of biologically active molecules to thwart cancer before it gains a foothold in the body-is that any such agents must be exceedingly safe, since it is likely that a person at risk for cancer would need to take the chemopreventive agent on a regular basis for a long time. Because of this requirement, many investigators have been screening naturally occuring molecules for ...
VELASCO-BEJARANO, Benjamín et al. Diindolylmethane Derivatives as Apoptosis Inductors in L5178y Cells. J. Mex. Chem. Soc [online]. 2008, vol.52, n.3, pp.224-228. ISSN 1870-249X.. Cell growth and division are highly regulated processes, although a notable exception is provided by the cancer cell, which arises as a variant that has lost the usual proliferation control pathways. Consequently, there is growing interest in the search for antitu-moral substances with high efficacy, low toxicity, and minimum side effects. In this sense, we synthesize eight diindolylmethane derivatives and the in vitro antitumor activity against murine L5178Y lymphoma cells was assessed. The preliminary results showed that the substituent and its position on the phenyl group were important for its potency against the lymphoma cells tested. Compound 3a was the most active compound with 93 % cell grown inhibition and 71.04% of apoptosis.. Palabras clave : DIM derivatives; apoptosis; cytotoxic effects; L5178Y cells. ...
B144 Hepatocellular carcinoma (HCC) is a common complication of hepatitis C cirrhosis. Because of immigration from countries with a high prevalence of hepatitis B, as well as the increasing age of Americans who contracted hepatitis C during the 1960s through 1980s, the incidence of HCC is increasing in the United States, and is projected to double between 2000 and 2010. At present, there is no effective chemopreventive agent for HCC. Epidemiologic studies have reported an increased risk for HCC among males and in patients with cirrhosis, older age and elevated serum level of alpha-fetoprotein (AFP). SAMe has been used as a drug in Italy and other European countries for more than 20 years. It has an excellent safety profile. In the body, SAMe is a component of the methionine cycle and is found in all cells. Inactivation of methionine adenosyl transferase in cirrhosis reduces the conversion of methionine into SAMe. The resulting reduction in SAMe level may contribute to decreased synthesis of ...
Turmeric is the most studied herb with coumarins. A study evaluated the chemopreventative effects of curcumin, the most active coumarin, on radiation- induced tumors in rat mammary glands. One control group was fed a basic diet while the other control group was fed a diet containing 1% curcumin. The control group fed curcumin had 28% reduction in tumors while 84% of the other group developed mammary tumors. Other studies also show that curcumin inhibits chemically-induced carcinogenesis of the skin, colon, and stomach. ...
Chronic inflammation and nuclear factor-kappa B (NFkappaB) have been implicated in prostate cancer development; thus, dietary factors that inhibit NFkappaB may serve as effective chemo-preventative agents. Prostate cancer risk is significantly lower in Asian countries compared to the United States, which has prompted interest in the potential chemopreventative action of Asian dietary components such as soy and green tea. This study examined the effects of dietary soy and tea on NFkappaB activation and inflammation in vivo using a hormone-induced rat model for prostate cancer. Male Noble rats implanted with estradiol and testosterone were divided into 4 dietary groups: control, soy, tea, or soy+tea. NFkappaB activation and inflammatory cytokines were measured post implantation. The combination of soy and tea suppressed NFkappaB p50 binding activity and protein levels via induction of IkappaBalpha. Soy and tea also decreased prostate inflammatory infiltration, increased Bax/BcL2 ratio and ...
Despite recent advances in medicinal chemistry, intrinsic and acquired resistance to chemotherapy treatments and the possibility of relapse present drawbacks in the treatment of breast cancer [39]. Because of the clear risks posed by chemotherapy, researchers worldwide have started searching for natural products that have better anti-carcinogenic activity without side effects. In addition, we believe that long chemotherapy treatment weakens the immunological defense system of the body and leaves patients susceptible to other infections and diseases. Radiation therapy is another treatment to combat cancer but also shows several potentially harmful side effects including weakened immune system and the potential to induce carcinogenesis itself. Therefore, there is an urgent need to develop chemoprevention approaches for the prevention of cancer. Chemoprevention is an important function area of oncology that focuses on the prevention of cancer using natural or synthetic agents. Recently, natural ...
Taking oxygen as a vitamin O supplement is a practice not endorsed by any major medical organization. There appears to be two types of vitamin O products available on the market. The first is an expensive health supplement that is composed largely of salt water and stabilized or aerobic oxygen, and is marketed under many different brand names. Companies, such as RGarden have advertised vitamin O (without germanium) as a purported cure or preventive agent for serious diseases such as cancer, heart disease, and lung disease. It has also been claimed that when taken by mouth, vitamin O supplements may enrich the bloodstream with supplemental oxygen. The second vitamin O product currently available contains the element germanium, which when synthetically derived has been said to be potentially nontoxic and safe at high doses. The various health claims for use of vitamin O have not been substantiated with scientific evidence. However, numerous product testimonials mention the effects of vitamin ...
Not kidding. A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications Nicotine may be suggested as a potential preventive agent...
such a new brilliant approach to eradicate cancer! this is interesting and beneficial as the bacterial proteins termed azurin & ATP-01 not only found effective in anticancer but also cancer preventive activity. Besides, because those bacteria are naturally-occurring human bacterial symbionts, i think it is higher chances to reduce/prevent immunogenicity and always non-toxic to human. its great to hear that ATP-01 also effective in anti-HIV/AIDS activity, should be a great invention and discovery! ...
1) Great natural anti-inflammatory. Acay berries contain powerful antioxidants known as tannins, which are famous for their impressive anti-inflammatory activity. Research has revealed high inflammation levels often accompany chronic conditions such as diabetes, cardiovascular disease and cancer. Treating inflammation is a first step towards the prevention of chronic illness.. 2) Anti-carcinogenic activity. Carcinogens are natural or synthetic (man-made) substances that damage normal, healthy cells and cause them to turn into cancer cells. Ellagic acid, a potent compound found in the acay berry, prevents certain carcinogens such as nitrosamines from food from binding to our DNA and causing cancerous formations. Regular consumption of the berries thus constitutes an important factor in the prevention of certain forms of cancer.. 3) Promotes cardiovascular health. Acay berries contain Omega-9 and Omega-6 fatty acids in the form of oleic acid and linoleic acid. These healthy monounsaturated and ...
1) Great natural anti-inflammatory. Acay berries contain powerful antioxidants known as tannins, which are famous for their impressive anti-inflammatory activity. Research has revealed high inflammation levels often accompany chronic conditions such as diabetes, cardiovascular disease and cancer. Treating inflammation is a first step towards the prevention of chronic illness.. 2) Anti-carcinogenic activity. Carcinogens are natural or synthetic (man-made) substances that damage normal, healthy cells and cause them to turn into cancer cells. Ellagic acid, a potent compound found in the acay berry, prevents certain carcinogens such as nitrosamines from food from binding to our DNA and causing cancerous formations. Regular consumption of the berries thus constitutes an important factor in the prevention of certain forms of cancer.. 3) Promotes cardiovascular health. Acay berries contain Omega-9 and Omega-6 fatty acids in the form of oleic acid and linoleic acid. These healthy monounsaturated and ...
11. Garlic, For centuries garlic has been used as natural medicine to prevent or treat a wide range of diseases and conditions. Multiple studies published throughout the last 10 years confirm that using small amounts of herbs and spices in recipes can yield big health benefits. A review of garlics impact on heart health found that this flavorful herb may help to improve cholesterol and triglyceride levels and aid in blood clotting. Other studies have showed that consuming garlic may help protect against stomach and colorectal cancers. You can reap garlics health benefits by chopping it finely to release allinase, an enzyme that aids in the formation of garlics cancer-protective compounds. Since cooking stops the activity of this beneficial enzyme, its best to let crushed garlic stand for 10 minutes after chopping, before adding it to heat - this prevents total loss of its anti-carcinogenic activity ...
Arathi, Bangalore Prabhashankar. and Raghavendra-Rao Sowmya, Poorigali and Kuriakose, Gini Chempakathinal. and Shilpa, Shivaprasad. and Shwetha, Hulikere Jagdish. and Sharath Kumar, . and Marisiddaiah Raju, . and Baskaran, Vallikannan. and Lakshminarayana, Rangaswamy. (2018) Fractionation and Characterization of Lycopene-Oxidation Products by LC-MS/MS (ESI)+: Elucidation of the Chemopreventative Potency of Oxidized Lycopene in Breast-Cancer Cell Lines. Journal of Agricultural and Food Chemistry, 66 (43). pp. 11362-11371. ISSN 0021-8561 Arathi, Bangalore Prabhashankar. and Sowmyaa, Poorigali Raghavendra-Rao. and Kuriakose, Gini Chempakathinal. and Vijaya, Kariyappa. and Baskaran, Vallikannan. and Jayabaskaran, Chelliah. and Lakshminarayana, Rangaswamy. (2016) Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines. Food and Chemical Toxicology, 97. pp. 265-276. ISSN 0278-6915 ...
The article discusses research indicating that stilbenes, the phytochemicals in grapes and berries, may help prevent cancer of the colon.. ...
Primary screening for HPV provides 60% - 70% greater protection against invasive cervical cancer than the cytology-based screening currently used.
New research published in JAMA Internal Medicine suggests that anticoagulant warfarin may reduce the incidence of cancer in older adults.
Most medical authorities recommend a colonoscopy as the preferred and most accurate screening tool for identification of colorectal cancer in its early stages.
Reducing the size, weight, and density of stools to the norm, is the most important and effective step toward the goal of preventing colorectal cancer.
Cell motility involves metastasis suppressors and other regulators that play an important role in tumor invasion and metastasis. Phenethyl isothiocyanate (PEITC), found in dietary cruciferous vegetables, has been found to exhibit antitumor properties and therefore is of special interest for the development of chemopreventive and chemotherapeutic agent for human cancers. Here, we report that in addition to its function as an anticancer agent, and PEITC can inhibit migration and invasion through the extracellular signal-regulated kinases 1/2 (ERK1/2), protein kinase C (PKC) and nuclear factor-kappaB (NF-kappaB) signaling pathways in human gastric cells. The results from wound healing and Boyden chamber assays (migration and invasion) assay indicated that PEITC exhibited an inhibitory effect on the migration and invasion of AGS cells. Results from Western blotting examination demonstrated that PEITC exerted an inhibitory effect on the ERK1/2, mitogen-activated protein kinase kinase 7 (MKK7), MAP ...
Diindolylmethane is suggested to balance levels of estrogen, creating a healthy hormone balance for both men and women. Effects can relieve...
The new nanoparticle, which delivers the drug in a form activated when it reaches its target, also treats tumors more effectively than the unadorned drug in mice.
A group of scientists at UCLA have cooked up some compounds that could harness the cancer-fighting properties of metformin while avoiding the biological hurdles that have limited its effect in past studies. And Enlibrium, a weeks-old startup, has licensed those assets and raised a $15 million in Series A cash to test out the idea.
Introduction and objective: The anticarcinogenic potential of milk fat can be attributed to its antioxidant, anti-inflammatory, immunostimulatory properties as well as the presence of compounds with antimutagenic effects. In view of the high incidence of cancer the aim of this article was to...
Buy DIM Diindolymethane Capsules. DIM Diindolymethane aids healthy estrogen metabolism and helps balance hormones for men and women. We offer it for only...
Cancer is one of the fatal diseases, and it continues to pose a significant health problem worldwide. Although great efforts are being done to discove..
Pure Encapsulations Indole-3-Carbinol 200 mg is a cruciferous phytonutrient that promotes prostate, breast and cervix health. Made in USA.
CARBINÓL, carbinoli, s.m. Denumire veche a alcoolului metilic. - Din fr. carbinol. Trimis de valeriu, 11.02.2003. Sursa: DEX 98  CARBINÓL s. v. alcool metilic, metanol. Trimis de siveco, 05.08.2004. Sursa: Sinonime  carbinól s. m., pl.…
this group is for every human being who wants to avoid or who has cancer and whats to do something about it - 801010 LFRV is a cancer preventive.
The University of Colorado currently holds patents for the use of etomoxir as an anti-inflammatory and anticarcinogenic agent. ... Etomoxir and a 2-deoxy-D-glucose Compound; Antiinflammatory, Antiproliferative, Anticarcinogenic and Wound Healing Agents; Drug ...
Karolyhazy G, Havas I, Jansco G, Kapas L, Sellei C (August 1952). "[The anticarcinogenic effect of dimethylaminoacetyl- ... Dictionary of Pharmacological Agents. Vol. 1. Boca Raton: Chapman & Hall/CRC. p. 711. ISBN 0-412-46630-9. Retrieved on August 2 ...
As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. Hydrazine sulfate ... It can also be anti-carcinogenic under certain conditions. At low concentrations, cadmium is able to stimulate the immune ...
... of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin ...
The leaves may contain agents for prevention of cancers (although they have no demonstrated anticarcinogenic properties) and ...
It has also been shown that myricetin can itself act as an agent of mutagenicity. Myricetin can produce frameshift mutations in ... Clearly there is a multifaceted, complex system involved in the anticarcinogenic activity displayed by myricetin that does not ... Basli A, Soulet S, Chaher N, Merillon JM, Chibane M, Monti JP, Richard T (July 2012). "Wine polyphenols: potential agents in ... Myricetin's pro-oxidative capabilities can also be seen in its ability to act as an inhibitory agent against glutathione ...
... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... anticarcinogenic - anticoagulant - anticonvulsant - antidepressant - antiemetic - antiestrogen - antifolate - antifungal ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ... adjunct agent - adjunctive therapy - adjuvant therapy - adrenocortical - Adriamycin - adult T-cell leukemia/lymphoma - AE-941 ...
Alkylating agents such as cyclophosphamide and cisplatin, as well as intercalating agent such as daunorubicin and doxorubicin ... Antioxidants are an important group of anticarcinogenic compounds that may help remove ROS or potentially harmful chemicals. ... Infectious agents have been suggested to cause cancer as early as 1908 by Vilhelm Ellermann and Oluf Bang, and 1911 by Peyton ... Alkylating agents such as ethylnitrosourea. The compounds transfer methyl or ethyl group to bases or the backbone phosphate ...
et Zucc is used as anti-inflammatory agent and anti-carcinogenic. Daphnetin shows several neuroprotective and anti-inflammatory ...
Used as a drying agent in paints and varnishes. Tung oil, used as an industrial lubricant and highly effective drying agent. ... Of current research interest for its potential anti-carcinogenic properties. Bottle gourd oil, extracted from the seeds of the ... Dammar oil, from the Canarium strictum, used in paint as an oil drying agent. Can also be used as a lamp oil. Linseed oil's ... Used as a flavoring agent and in aromatherapy. Orange oil, like lemon oil, cold pressed rather than distilled. Consists of 90% ...
Griseofulvin, clotrimazole and miconazole are antimycotic agents that are used to treat M. nanum and T. rubrum. Of three human ... antimutagenic and anticarcinogenic activities. Both neem seed and neem leaves are capable of killing M. nanum. The minimum ... Like many other dermatophytes, M. nanum is tolerant of the antifungal agent cycloheximide. In addition, M. nanum also exhibits ...
... s are different from anticarcinoma agents (also known as anticancer or anti-neoplastic agents) in that ... Confirmation that a substance possesses anticarcinogenic activity requires extensive in vitro, in vivo, and clinical ... An anticarcinogen (also known as a carcinopreventive agent) is a substance that counteracts the effects of a carcinogen or ... Chemopreventive agents, All stub articles, Antineoplastic and immunomodulating drug stubs). ...
... also exhibits anti-carcinogenic activity. In vivo two-stage carcinogenesis tests of mouse skin tumor showed that ... "Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer's disease: Effects against scopolamine and ... "Anti-carcinogenic Activity of Taraxacum Plant. II". Biological & Pharmaceutical Bulletin. 22 (6): 606-610. doi:10.1248/bpb. ...
... is an inhibitor of skeletal muscle atrophy, and a potential therapeutic agent for aging-associated sarcopenia, ... "Anticarcinogenic, Cardioprotective, and Other Health Benefits of Tomato Compounds Lycopene, α-Tomatine, and Tomatidine in Pure ...
p53, and with it PUMA, is activated due to DNA damage caused by a variety of genotoxic agents. Other agents that induce p53 ... Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (June 2009). "Multiple molecular targets of resveratrol: Anti-carcinogenic ... Therapeutic agents targeting PUMA for cancer patients are emerging. PUMA inducers target cancer or tumor cells, while PUMA ... Yu J, Yue W, Wu B, Zhang L (May 2006). "PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation". Clin. ...
"Chemical agents and related occupations, Volume 100F. A review of human carcinogens" (PDF). International Agency for Research ... but also because they have been shown to have anticarcinogenic, antimutagenic, antioxidative, and antimicrobial properties. ...
A chemical may both have anti-carcinogenic properties and yet still be a co-carcinogen in combination with some carcinogens. ... a cancer chemopreventive agent or a co-carcinogen?". Mutation Research/Reviews in Mutation Research. 543 (3): 195-200. doi: ... or anti-carcinogenic. In recent years, people substitute health supplements for healthy meals.[citation needed] Some myths even ...
... anticarcinogenic agents MeSH D27.505.954.248.144 - antimetabolites, antineoplastic MeSH D27.505.954.248.147 - antimitotic ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Therefore, withaferin A can be a potential therapeutic agent for the treatment of cervical cancer without major side effects. ... anti-metastasis and anti-carcinogenic properties. Withanolides are a group of naturally occurring C28- steroidal lactones. They ... Lee, In-Chul; Choi, Bu Young (2016). "Withaferin-A-A Natural Anticancer Agent with Pleitropic Mechanisms of Action". ... 2007). "The tumor inhibitor and antiangiogenic agent Withaferin A targets the intermediate filament protein Vimentin". ...
Saponins and phytates may exhibit hypocholesterolaemic and anticarcinogenic activities. Trypsin inhibitors decrease the ... foaming agent, or an emulsifier. It is extracted in a powder form and can be processed and produced in different ways: As an ...
In food manufacturing, it is used as a flavoring agent. In humans, butyric acid is one of two primary endogenous agonists of ... it has pronounced antimicrobial and anticarcinogenic effects) in humans. These effects occur through its metabolism by ... Agents Chemother. 55 (6): 2897-904. doi:10.1128/AAC.00016-11. PMC 3101455. PMID 21464244. Zimmerman MA, Singh N, Martin PM, ...
Laboratory experiments have suggested that cannabis and cannabinoids have anticarcinogenic and antitumor effects, including a ... "Current Status and Prospects for Cannabidiol Preparations as New Therapeutic Agents". Pharmacotherapy. 36 (7): 781-96. doi: ... and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, confounds and ...
This effect may be responsible for both anticarcinogenic and carcinogenic potential of the substance. It was found to ... Antimicrobial Agents and Chemotherapy. 50 (11): 3770-8. doi:10.1128/AAC.00578-06. PMC 1635224. PMID 16954323. Si, Hongwei; Liu ... of Combination Effects for the Induction of Micronuclei in Mouse Lymphoma Cells by Binary Mixtures of the Genotoxic Agents MMS ...
Implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine". Nutrition and Cancer. 40 ( ... that methaneseleninic acid shows promise as a sensitizing agent for apoptosis induced by the Bcl-2-family inhibitor ABT-737 in ...
Anticarcinogenic Agents* / pharmacology Actions. * Search in PubMed * Search in MeSH * Add to Search ... Signaling pathways and the potential anticarcinogenic effect of native Brazilian fruits on breast cancer Lívia Mateus Reguengo ... Signaling pathways and the potential anticarcinogenic effect of native Brazilian fruits on breast cancer Lívia Mateus Reguengo ...
Isothiocyanates (ITC) are well-known chemopreventive agents extracted from vegetables. This activity results from the ... Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Zhang Y, Talalay P. Zhang Y, et al. Cancer ... The anticarcinogenic effects of isothiocyanates appear to be mediated by tandem and cooperating mechanisms: (a) suppression of ... Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanisms. Zhang Y, et al. Cancer Res. 1994. PMID: ...
Many mechanisms have been shown to account for the anticarcinogenic actions o … ... Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from ... Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from ... Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently ...
Anticarcinogenic Agents / therapeutic use* * Aryl Hydrocarbon Hydroxylases / analysis * Breast Neoplasms / prevention & control ... DNA mutation caused by this genotoxic agent is a crucial step in cancer initiation. Substances that interfere with the CYP1 ...
... anticarcinogenic agents, immunomodulators]. US patent 4,876,244. 1989 Oct 24. ...
Pharmacological Actions : Anticarcinogenic Agents. Additional Keywords : Isothiocyanates. [+] Sulfur fertilization ...
Pharmacological Actions : Anticarcinogenic Agents. [+] A review of dietary carotenoids in cancer chemoprevention and ... Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-1 beta downregulation, Tumor Necrosis Factor (TNF) Alpha ...
Pharmacological Actions : Anticarcinogenic Agents. Additional Keywords : Risk Factors. [+] Mind and body therapies many ... Pharmacological Actions : Bcl-2 protein down-regulation, Neuroprotective Agents. Problem Substances : Monosodium Glutamate (MSG ...
Read more about a well-known compound of the flavonoid family that has been recently used as a hepatoprotective agent. ... Agent. Experimental model. Silymarin or silibinin action. References. Phenylhydrazine. Rat erythrocytes. Inhibition of ... Anti-inflammatory and anticarcinogenic properties have also been documented.. Silymarin is able to neutralise the ... Agent. Experimental model. Dose (intravenous) of silymarin or silibinin (mg/kg). Action. References. ...
Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View ... Int.J Antimicrob.Agents 1999;12:257-262. View abstract.. * Soetiarto, F. The relationship between habitual clove cigarette ... Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract ...
Anticarcinogenic Agents. Atwell LL, Zhang Z, Mori M, Farris P, Vetto JT, Naik AM, Oh KY, Thuillier P, Ho E, Shannon J. 2015. ...
MeSH Terms: Action Potentials; Adult; Anticarcinogenic Agents; Antioxidants/pharmacology; Apoptosis/drug effects; Catechin/ ...
MeSH Terms: Anticarcinogenic Agents; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Communication*; Diet*; Gap Junctions/ ... The tumor-promotion process requires sustained exposure to agents that stimulate the growth and inhibition of apoptosis of ... Most, if not all, tumor-promoting agents and conditions, reversibly, inhibit cell-cell communication, whereas antipromoters, ... antioxidants, and anti-inflammatory agents have been shown to ameliorate the effects of tumor promoters on cell-cell ...
Anticarcinogenic Agents / administration & dosage* Actions. * Search in PubMed * Search in MeSH * Add to Search ...
It also has been used as a flavoring and aroma agent. Its biological activity is attributed largely to its double bond and ... Withaferin A has many potential pharmaceutical uses because of its anti-inflammatory, anticarcinogenic, and cardioprotective ...
The molecular structures of these agents are shown in Figure 1.. 2. Promising Phytochemicals. 2.1. Grape Seed Proanthocyanidins ... This effects may represent one of the possible mechanisms action of that mediate the anti-carcinogenic effects of honokiol in ... Thus, tumor xenograft models were used to further determine the anti-carcinogenic effects of GSPs. The GSPs were administered ... Notably, they all target multiple molecular targets in a manner that is consistent with their anti-carcinogenic effects, as ...
Flavonoids are one of the main subclasses of dietary polyphenols and possess strong antioxidant activity and anti-carcinogenic ... Luteolin, a flavonoid, as an anticancer agent: A review. Biomed. Pharmacother. 2019, 112, 108612. [Google Scholar] [CrossRef] ... Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies by Carmen Rodríguez-García ... Recently, interest in flavonoids has increased because their strong antioxidant and anti-carcinogenic activities may have ...
Moreover, to our knowledge, these findings provide the first molecular basis for the anti-carcinogenic action of quercitrin. ... a validated model for screening cancer chemopreventive agents and elucidating the molecular mechanisms. Quercitrin blocked TPA- ... Extensive studies have demonstrated that quercitrin exhibits strong antioxidant and anti-carcinogenic activities. However, the ...
More effective sunscreens and nontoxic anticarcinogenic agents should be developed as approaches to diminishing the risk of UVR ... anti-inflammatory agents such as indomethacin. These anti-inflammatory agents, however, cannot inhibit the delayed, post 24- ... Sunscreening Agents: Chemical and Physical Design and Use. Dermatology Division. University of California at Los Angeles ... In addition, there is increasing interest in pharmacologic agents such as the retinoids that may be capable of inhibiting the ...
Zhang Y., Talalay P. Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. ... Actual Intake of Chemopreventive Agents.. The actual intake of each chemopreventive agent was calculated by taking into account ... B in ETS-exposed rats without chemopreventive agents, and C in ETS-exposed rats with each chemopreventive agent. The resulting ... Five chemopreventive agents were given either with drinking water (N-acetyl-l-cysteine, 1 g/kg body weight/day) or with the ...
... thereby highlighting the use of this bioflavanoid as effective chemopreventive agent relevant to prostate cancer progression. ... and anti-inflammatory properties of Ashwagandha might contribute to its overall effectiveness as an anti-carcinogenic agent. ... and anti-inflammatory properties of Ashwagandha might contribute to its overall effectiveness as an anti-carcinogenic agent. ... thereby highlighting the use of this bioflavanoid as effective chemopreventive agent relevant to prostate cancer progression. ...
Vitamin D is an environmental and dietary agent with known anticarcinogenic effects, but protection against breast cancer has ...
To confine the coloring matter to the design area, it is pasted with the help of a thickening agent. A successful print ... It possesses antibacterial, anticarcinogenic, antiviral, cytotoxic and anti-inflammatory properties. The phytochemical ... The chief active constituent azadirachtin is an effective antimicrobial agent.. Neem Gum is normally exudates from Neem tree by ... Chemicals: Chemicals such as urea (NH2CONH2), sodium bicarbonate (NaHCO3), wetting agent (soap), sodium chloride (NaCl), m- ...
Anticarcinogenic Agents * Antihypertensive Agents * Antimutagenic Agents * Antioxidants / analysis * Biological Availability * ...
As it boasts antioxidant, warming agents and of course antimicrobial, anti-carcinogenic and anti-tumor properties free,! Of ... warming agents and of course antimicrobial, anti-carcinogenic and properties! Spices » 50 Scientific health benefits that ... Cinnamon contains antimicrobial agents that ceylon cinnamon benefits kill all the bacteria that cause the.. Is reducing the ... Of Dragon Fruit - health benefits to those who consume it macronutrients helps! As it boasts antioxidant, warming agents and of ...
Streblus asper; adverse effects; anticarcinogenic activity; antineoplastic activity; antineoplastic agents; apoptosis; bark; ... Over the last 30 years, (±)-1-(9-fluorenyl)ethyl chloroformate ((±)-FLEC) was used as a chiral derivatizing agent in various ... or (−)-1-(9-fluorenyl)ethyl chloroformate as chiral derivatizing agent: A review ... has shown some potential for further investigation as an antineoplastic agent. A mechanistic study using an in vitro assay and ...
Chemopreventive agents can be classified by their timing of anticarcinogenic actions into those that inhibit tumor initiation, ... Chemopreventive agents effective in the initiation phase are often carcinogen-specific. These agents may act by altering the ... agents initiating carcinogenesis such as AOM, are mutagenic, whereas tumor-promoting agents are usually nonmutagenic. In this ... Moreover, it should be emphasized that agents effective in this phase are clearly not acting only to inhibit the activity of ...
The study concluded that Chlorella vulgaris is an antioxidant agent that could be suitable for reducing liver oxidative stress ... anticarcinogenic, and also serving as an antitoxic agent [5]. In a bid to facilitate the understanding of the mechanisms of the ... The study concluded that Chlorella vulgaris is an antioxidant agent that could be suitable for reducing liver oxidative stress ... The microalga Chlorella vulgaris is an antioxidant agent with confirmed capacity of oxidative stress in inhibition at different ...
54b] Anticarcinogenic effects of selenium. Schrauzer GN in Cell Mol Life Sci 2000 Dec;57(13-14):1864-73 ... There is a mistaken notion that simply because an agent is naturally occurring, it cannot be as beneficial as taking a ... 1a] The Use of Drosophila Melanogaster as a Screening Agent for Longevity Factors. I. Pantothenic Acid as a Longevity Factor in ... On the other hand curcumin7, an antioxidant with anti-carcinogenic properties, has extended maximum as well as mean lifespan, ...
  • Mottaghi S , Abbaszadeh H . Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. (wjgnet.com)
  • Notwithstanding the fact that many anticancer agents have been derived from medicinal plants, many plants with anticancer potentials are yet to be discovered. (springeropen.com)
  • Contains triclosan and sodium benzoate which are antifungal and antibacterial agent. (com.ng)
  • Evidence for chemoprevention by Se and for the apparent mechanisms underlying these effects is reviewed to the end of facilitating the development of the potential of Se compounds as cancer chemopreventive agents. (nih.gov)
  • The aims of this review are to report the different types of bioactive metabolites and their relevant producers, as well as the different mechanisms of action of mushroom compounds as potent anti-inflammatory agents. (hindawi.com)
  • The researchers found that Indian propolis is rich in flavonoids and phenolic compounds that make it an even better anti-cancer agent than the chemotherapy drug, 5-fluorouraci l. (oncology.news)
  • The most notable of these plant compounds are polyphenols, flavonoids and the anti-cancer agent, caffeic acid phenethyl ester (CAPE). (oncology.news)
  • Cabbage, the cruciferous vegetable from which sauerkraut is made, is already valued by natural food experts and nutritionists for its sky-high amounts of anticarcinogenic bioactive compounds. (naturalhealth365.com)
  • See all compounds classified as Anticarcinogenic Agents. (web.app)
  • The bioactive compounds are considered the promising source of natural anti-carcinogenic and anti-Inflammatory agents. (plantsjournal.com)
  • Clove oil has biological activities, such as antibacterial, antifungal, insecticidal and antioxidant properties, and is used traditionally as a savoring agent and antimicrobial material in food. (jadebloom.com)
  • Nowadays, many reports confirm the antibacterial, antifungal, antiviral and anticarcinogenic properties of spice plants. (jadebloom.com)
  • Turmeric and curcumin not only kill fully developed cancerous cells but also work as chemopreventive agents. (turmericforhealth.com)
  • Turmeric is a knows antioxidant and anticarcinogenic agent. (myfuturepharm.com)
  • Turmeric is a known antioxidant, anti-inflammatory and anti-carcinogenic agent. (bengalicuisine.net)
  • Being an antiviral agent, polyphenols help avoid the enzymes that accommodate viruses to grow in the cells. (coffeezoid.com)
  • Clove essential oil can be considered as a potential antimicrobial agent for external use. (jadebloom.com)
  • Although this range of exposure is above the estimated human daily intake (is approximately equal to 940 µg/day for 70 kg person or 13.4 µg/kg/day), these levels would not be unreasonable if EA were used as a dietary supplement or as a chemotherapeutic agent. (cdc.gov)
  • These observations suggest important implications on human health should EA be prescribed as a chemotherapeutic agent or a preventative dietary supplement for cancer. (cdc.gov)
  • 33] It is now well-documented that apoptosis or programmed cell death is the key mechanism by which chemotherapeutic agents exert their cytotoxicity. (researchgate.net)
  • International(NANDA-I)in1999(4)anditwentthroughrevisionsinthesubsequenteditionsthatresultedin changesinitsdefinition,aswel as,itsdefiningcharacteristicsandinthefactorsrelatedtoit(5-7).Withinits editionsthatpresentednausearelatedchanges,theNANDA-Iof2007and2008(6)broughtalargerquantity of reviews and almost al diagnoses presented few changes in its defining characteristics and in factors relatedtoitor,ofriskfactors.Itwasinthiseditionthatitwasobservedtheremovalof"chemotherapeutic agents"fromthenusingdiagnosis"nausea",whichisstil absentinthecurrentedition(7). (bvsalud.org)
  • The role of limonin as potent anti carcinogenic, apoptosis and chemotherapeutic agents has been supported by limited studies. (jnsbm.org)
  • Plant extracts are widely used in Nigeria as important sources of chemotherapeutic agents in spite of the use of synthetic drug by vast majority of the populace. (springeropen.com)
  • In a study published in 2011 in the British Journal of Nutrition , researchers noted that the detoxifying enzymes in sauerkraut juice have an anticarcinogenic effect on kidney and liver cancer cells and added that sauerkraut juice increased levels of glutathione-S-transferase - considered a chemoprotective agent. (naturalhealth365.com)
  • SFN has proved to be an effective chemoprotective agent in cell culture, in carcinogen-induced and genetic animal cancer models, as well as in xenograft models of cancer. (web.app)
  • Hence, identifying the promising chemopreventive agents in diets and their underlying molecular mechanisms have been considered to be the best strategy to protect against hepatocarcinogenesis [ 2 ]. (jcancer.org)
  • This multi-faceted action of curcumin makes it a novel anti-cancer agent that holds promise for future treatment options in cancer. (turmericforhealth.com)
  • Curcumin is also identified as a potential chemopreventive agent in breast and colon cancer . (turmericforhealth.com)
  • Find technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. (web.app)
  • These phenolic compound possess potent antioxidant activity that play an important role in human nutrition as preventative agents against several diseases caused by oxidative stress, protecting the body tissues against oxidative stress with their antioxidant, anti-mutagen, anti-inflammatory, and anti-carcinogenic properties [ 14 ]. (rroij.com)
  • As a preventive agent against cavities - The anti-microbial properties of propolis can inhibit the growth of oral bacteria like Streptococcus mutans . (oncology.news)
  • The healthcare-associated infections has stimulated research on utilizing anticarcinogenic and anti-inflammatory properties that catechins come with help in the expansion of the catechin market. (tmrresearch.com)
  • Liu H , Zang C, Emde A, Planas-silva MD, Rosche M, Kühnl A, Schulz C, Elstner E, Possinger K, Eucker J. Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer. (wjgnet.com)
  • In this study, limonin is identified as a potent anti proliferative agent against human hepatoma HepG2 cells based on the cell viability study, LDH leakage assay. (jnsbm.org)
  • 3 , 6 , 7 Gram-negative bacterial endotoxin present in cotton dust is likely a causative agent, able to produce airway inflammation and obstruction. (cdc.gov)
  • Based on these findings, the researchers concluded that the ethanolic extract of Indian propolis is a safe anti-carcinogenic agent that can be further developed into a natural anti-cancer medicine. (oncology.news)
  • The inclination of researchers to use catechins in onco-immunotherapeutic agent against the treatment of glioblastoma is a case in point. (tmrresearch.com)
  • Chemoprevention involves the administration of various agents that prevent potential premalignant cells from developing into cancer. (turmericforhealth.com)
  • Limonene is now recognized as an anticancer agent with real potential as a dietary anti-cancer tool in humans. (bioprogreen.com)
  • Broccoli är i detta sammanhang en mycket spännande grönsak Sulforafan - Antioxidant mot autism och cancer. (web.app)
  • There is an urgent need for more novel and efficacious therapeutic agents and strategies for the treatment of ovarian cancer - one of the most formidable female malignancies. (biomedcentral.com)
  • Beta-Carotene and Retinol, promoted as anti-carcinogenic agents, may promote lung cancer. (smartallabout.com)
  • these isothiocyanates have shown such pronounced anticarcinogenic effects in cellular, laboratory, and human studies. (naturalhealth365.com)
  • lymphoid tissue, and digestive tract), which the animal model captures the It can be difficult to parse out concordance has often been ob- range of potential human response reasons for lack of tumour site con- served among different species after to the particular agent tested. (who.int)
  • It reduces the synthesis of inflammatory agents in lipopolysaccharide (LPS)-induced THP-1 cells by intervening in the I-Kappa-B kinases (IKK-beta) and Kappa B signaling pathways. (news-medical.net)
  • Previous reports have demonstrated the anticarcinogenic effects of EA at levels 10- to 250-fold greater than those applied in this study. (cdc.gov)
  • Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (bvsalud.org)
  • Well I just added two new ePub agents to my agency because I believe every author writing today needs someone who understands this brave new world of epublishing, and can negotiate a new career path for writers that will take them to the future. (blogspot.com)
  • Taken together, these results indicate that CDDO-Me is a promising anticancer agent against ESCC. (dovepress.com)
  • These results suggest that KRG may prove to be a therapeutic agent against hepatocarcinogenesis. (jcancer.org)
  • To replace biohazardous nematicides, there is an ever-increasing need to identify natural product-based agents to contain root-knot nematodes (RKNs) in agriculture. (bvsalud.org)
  • Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. (shengsci.com)
  • Studies have shown that quercetin acts as an anti-carcinogenic, anti-bacterial, and anti-inflammatory agent. (tasteandsavor.com)
  • EMS responders will deliver the single, field, bolus dose of study agent, TSC at 0.25 mg/kg or matched placebo, followed after hospital arrival by standard of care (SOC). (clinicaltrials.gov)
  • It was also used by the Ancient Romans as a mouth disinfectant, an antiseptic and a wound healing agent . (oncology.news)
  • Some of the key application areas in the global catechin market are pharmaceutical, beverages, supplements, and mouth rinsing agents. (tmrresearch.com)
  • Sodium fluoride has been used for decades in dental practice as an effective anti-carcinogenic agent 12 . (bvsalud.org)