Anticarcinogenic Agents
Antimutagenic Agents
Trypsin Inhibitor, Bowman-Birk Soybean
Butylated Hydroxyanisole
9,10-Dimethyl-1,2-benzanthracene
Garlic
Plant Extracts
Croton Oil
Silymarin
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
Panax
Curcumin
Carcinogens
Benz(a)Anthracenes
Momordica charantia
Ellagic Acid
Tea
NAD(P)H Dehydrogenase (Quinone)
Norisoprenoids
Anisoles
Perilla frutescens
Antioxidants
Glutathione Transferase
Proanthocyanidins
Brassica
Caffeic Acids
Glucosinolates
Benzo(a)pyrene
Trypsin Inhibitors
Catechin
Linoleic Acids, Conjugated
Selenium
Plants, Medicinal
Enzyme Induction
Mutagenicity Tests
Isoflavones
Sulfides
Papilloma
Soybeans
Lignans
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Mammary Neoplasms, Experimental
Quercetin
Cell Transformation, Neoplastic
Antineoplastic Agents, Phytogenic
Neoplasms
Dose-Response Relationship, Drug
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Tumor Cells, Cultured
Cyclooxygenase 2
Molecular Structure
Liver
Neoplasms, Experimental
Carotenoids
Cell Division
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Colorectal Neoplasms
NF-kappa B
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Glutathione
Chromatography, High Pressure Liquid
Isoenzymes
Rats, Sprague-Dawley
Cell Survival
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Tomatoes, tomato-based products, lycopene, and cancer: review of the epidemiologic literature. (1/2345)
The epidemiologic literature in the English language regarding intake of tomatoes and tomato-based products and blood lycopene (a compound derived predominantly from tomatoes) level in relation to the risk of various cancers was reviewed. Among 72 studies identified, 57 reported inverse associations between tomato intake or blood lycopene level and the risk of cancer at a defined anatomic site; 35 of these inverse associations were statistically significant. No study indicated that higher tomato consumption or blood lycopene level statistically significantly increased the risk of cancer at any of the investigated sites. About half of the relative risks for comparisons of high with low intakes or levels for tomatoes or lycopene were approximately 0.6 or lower. The evidence for a benefit was strongest for cancers of the prostate, lung, and stomach. Data were also suggestive of a benefit for cancers of the pancreas, colon and rectum, esophagus, oral cavity, breast, and cervix. Because the data are from observational studies, a cause-effect relationship cannot be established definitively. However, the consistency of the results across numerous studies in diverse populations, for case-control and prospective studies, and for dietary-based and blood-based investigations argues against bias or confounding as the explanation for these findings. Lycopene may account for or contribute to these benefits, but this possibility is not yet proven and requires further study. Numerous other potentially beneficial compounds are present in tomatoes, and, conceivably, complex interactions among multiple components may contribute to the anticancer properties of tomatoes. The consistently lower risk of cancer for a variety of anatomic sites that is associated with higher consumption of tomatoes and tomato-based products adds further support for current dietary recommendations to increase fruit and vegetable consumption. (+info)Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. (2/2345)
BACKGROUND: Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of foods contaminated with aflatoxins, which require metabolic activation to become carcinogenic. In a randomized, placebo-controlled, double-blind phase IIa chemoprevention trial, we tested oltipraz, an antischistosomal drug that has been shown to be a potent and effective inhibitor of aflatoxin-induced hepatocarcinogenesis in animal models. METHODS: In 1995, 234 adults from Qidong were enrolled. Healthy eligible individuals were randomly assigned to receive by mouth 125 mg oltipraz daily, 500 mg oltipraz weekly, or a placebo. Sequential immunoaffinity chromatography and liquid chromatography coupled to mass spectrometry or to fluorescence detection were used to identify and quantify phase 1 and phase 2 metabolites of aflatoxin B1 in the urine of study participants. Reported P values are two-sided. RESULTS: One month of weekly administration of 500 mg oltipraz led to a 51% decrease in median levels of the phase 1 metabolite aflatoxin M1 excreted in urine compared with administration of a placebo (P = .030), but it had no effect on levels of a phase 2 metabolite, aflatoxin-mercapturic acid (P = .871). By contrast, daily intervention with 125 mg oltipraz led to a 2.6-fold increase in median aflatoxin-mercapturic acid excretion (P = .017) but had no effect on excreted aflatoxin M1 levels (P = .682). CONCLUSIONS: Intermittent, high-dose oltipraz inhibited phase 1 activation of aflatoxins, and sustained low-dose oltipraz increased phase 2 conjugation of aflatoxin, yielding higher levels of aflatoxin-mercapturic acid. While both mechanisms can contribute to protection, this study highlights the feasibility of inducing phase 2 enzymes as a chemopreventive strategy in humans. (+info)Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. (3/2345)
BACKGROUND: Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory effects on the growth and invasive properties of human mammary cancer cells in vitro; furthermore, the two agents have displayed additive effects in vitro. In this study, we examined whether tangeretin would enhance tamoxifen's therapeutic benefit in vivo. METHODS: Female nude mice (n = 80) were inoculated subcutaneously with human MCF-7/6 mammary adenocarcinoma cells. Groups of 20 mice were treated orally by adding the following substances to their drinking water: tamoxifen (3 x 10(-5) M), tangeretin (1 x 10(-4) M), tamoxifen plus tangeretin (3 x 10(-5) M plus 1 x 10(-4) M), or solvent. RESULTS AND CONCLUSIONS: Oral treatment of mice with tamoxifen resulted in a statistically significant inhibition of tumor growth compared with solvent treatment (two-sided P = .001). Treatment with tangeretin did not inhibit tumor growth, and addition of this compound to drinking water with tamoxifen completely neutralized tamoxifen's inhibitory effect. The median survival time of tumor-bearing mice treated with tamoxifen plus tangeretin was reduced in comparison with that of mice treated with tamoxifen alone (14 versus 56 weeks; two-sided P = .002). Tangeretin (1 x 10(-6) M or higher) inhibited the cytolytic effect of murine natural killer cells on MCF-7/6 cells in vitro, which may explain why tamoxifen-induced inhibition of tumor growth in mice is abolished when tangeretin is present in drinking water. IMPLICATIONS: We describe an in vivo model to study potential interference of dietary compounds, such as flavonoids, with tamoxifen, which could lead to reduced efficacy of adjuvant therapy. In our study, the tumor growth-inhibiting effect of oral tamoxifen was reversed upon addition of tangeretin to the diet. Our data argue against excessive consumption of tangeretin-added products and supplements by patients with mammary cancer during tamoxifen treatment. (+info)Cyclin D1 proteolysis: a retinoid chemoprevention signal in normal, immortalized, and transformed human bronchial epithelial cells. (4/2345)
BACKGROUND: Retinoids (derivatives of vitamin A) are reported to reduce the occurrence of some second primary cancers, including aerodigestive tract tumors. In contrast, beta-carotene does not reduce the occurrence of primary aerodigestive tract cancers. Mechanisms explaining these effective retinoid and ineffective carotenoid chemoprevention results are poorly defined. Recently, the all-trans-retinoic acid (RA)-induced proteolysis of cyclin D1 that leads to the arrest of cells in G1 phase of the cell cycle was described in human bronchial epithelial cells and is a promising candidate for such a mechanism. In this study, we have investigated this proteolysis as a common signal used by carotenoids or receptor-selective and receptor-nonselective retinoids. METHODS: We treated cultured normal human bronchial epithelial cells, immortalized human bronchial epithelial cells (BEAS-2B), and transformed human bronchial epithelial cells (BEAS-2BNNK) with receptor-selective or receptor-nonselective retinoids or with carotenoids and studied the effects on cell proliferation by means of tritiated thymidine incorporation and on cyclin D1 expression by means of immunoblot analysis. We also examined whether calpain inhibitor I, an inhibitor of the 26S proteasome degradation pathway, affected the decline (i.e., proteolysis) of cyclin D1. RESULTS: Receptor-nonselective retinoids were superior to the carotenoids studied in mediating the decline in cyclin D1 expression and in suppressing the growth of bronchial epithelial cells. Retinoids that activated retinoic acid receptor beta or retinoid X receptor pathways preferentially led to a decrease in the amount of cyclin D1 protein and a corresponding decline in growth. The retinoid-mediated degradation of cyclin D1 was blocked by cotreatment with calpain inhibitor I. CONCLUSIONS: Retinoid-dependent cyclin D1 proteolysis is a common chemoprevention signal in normal and neoplastic human bronchial epithelial cells. In contrast, carotenoids did not affect cyclin D1 expression. Thus, the degradation of cyclin D1 is a candidate intermediate marker for effective retinoid-mediated cancer chemoprevention in the aerodigestive tract. (+info)Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy. (5/2345)
Full term pregnancy early in life is the most effective natural protection against breast cancer in women. Rats treated with chemical carcinogen are similarly protected by a previous pregnancy from mammary carcinogenesis. Proliferation and differentiation of the mammary gland does not explain this phenomenon, as shown by the relative ineffectiveness of perphenazine, a potent mitogenic and differentiating agent. Here, we show that short term treatment of nulliparous rats with pregnancy levels of estradiol 17beta and progesterone has high efficacy in protecting them from chemical carcinogen induced mammary cancers. Because the mammary gland is exposed to the highest physiological concentrations of estradiol and progesterone during full term pregnancy, it is these elevated levels of hormones that likely induce protection from mammary cancer. Thus, it appears possible to mimic the protective effects of pregnancy against breast cancer in nulliparous rats by short term specific hormonal intervention. (+info)Inhibition of aberrant proliferation and induction of apoptosis in HER-2/neu oncogene transformed human mammary epithelial cells by N-(4-hydroxyphenyl)retinamide. (6/2345)
Epithelial cells from non-cancerous mammary tissue in response to exposure to chemical carcinogens or transfection with oncogenes exhibit hyperproliferation and hyperplasia prior to the development of cancer. Aberrant proliferation may, therefore, represent a modifiable early occurring preneoplastic event that is susceptible to chemoprevention of carcinogenesis. The synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR), has exhibited preventive efficacy in several in vitro and in vivo breast cancer models, and represents a promising chemopreventive compound for clinical trials. Clinically relevant biochemical and cellular mechanisms responsible for the chemopreventive effects of HPR, however, are not fully understood. Experiments were performed on preneoplastic human mammary epithelial 184-B5/HER cells derived from reduction mammoplasty and initiated for tumorigenic transformation by overexpression of HER-2/neu oncogene, to examine whether HPR inhibits aberrant proliferation of these cells and to identify the possible mechanism(s) responsible for the inhibitory effects of HPR. Continuous 7-day treatment with HPR produced a dose-dependent, reversible growth inhibition. Long-term (21 day) treatment of 184-B5/HER cells with HPR inhibited anchorage-dependent colony formation by approximately 80% (P < 0.01) relative to that observed in the solvent control. A 24 h treatment with cytostatic 400 nM HPR produced a 25% increase (P = 0.01) in G0/G1 phase, and a 36% decrease (P = 0.01) in S phase of the cell cycle. HPR treatment also induced a 10-fold increase (P = 0.02) in the sub-G0 (apoptotic) peak that was down-regulated in the presence of the antioxidant N-acetyl-L-cysteine. Treatment with HPR resulted in a 30% reduction of cellular immunoreactivity to tyrosine kinase, whereas immunoreactivity to p185HER remained essentially unaltered. HPR exposure resulted in time-dependent increase in cellular metabolism of the retinoid as evidenced by increased formation of the inert metabolite N-(4-methoxyphenyl)-retinamide (MPR) and progressive increase in apoptosis. Thus, HPR-induced inhibition of aberrant proliferation may be caused, in part, by its ability to inhibit HER-2/neu-mediated proliferative signal transduction, retard cell cycle progression and upregulate cellular apoptosis. (+info)Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. (7/2345)
Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for the prevention of cancer. However, the mechanism of the anti-carcinogenic activity of resveratrol is not well understood. Here we offer a possible explanation of its anti-cancer effect. Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis. (+info)Effect of retinoids on AOM-induced colon cancer in rats: modulation of cell proliferation, apoptosis and aberrant crypt foci. (8/2345)
We have previously reported that the retinoids, 4-(hydroxyphenyl)retinamide (4-HPR) and 9-cis-retinoic acid (RA) prevented azoxymethane (AOM)-induced colon tumors and along with 2-(carboxyphenyl)retinamide (2-CPR) prevented aberrant crypt foci (ACF). In this study, we evaluated the effect of 2-CPR on AOM-induced colon tumors and the effect of the three retinoids on apoptosis and cell proliferation. Male F344 rats were administrated 15 mg/kg AOM at weeks 7 and 8 of age. 2-CPR (315 mg/kg) was administered in the diet starting either 1 week before or at week 12 after the first dose of AOM. The rats continued to receive the 2-CPR until killed at week 46. Unlike the demonstrated prevention of colon cancer by the other two retinoids, both dosing schedules of 2-CPR resulted in an approximate doubling of the yield of colon tumors. In adenomas, 2-CPR, 4-HPR and 9-cis-RA were equally effective in reducing mitotic activity, while only 4-HPR and 9-cis-RA but not 2-CPR enhanced apoptosis. When administered for only the 6 days prior to killing 4-HPR but not 2-CPR decreased the Mitotic Index and increased the Apoptotic Index in adenomas. In non-involved crypts, chronic exposure to 4-HPR and 9-cis-RA in contrast to 2-CPR reduced the Mitotic Index and enhanced the Apoptotic Index. In concurrence with our previous study, both 2-CPR and 4-HPR were very potent in preventing ACF when administered in the diet starting 1 week before the first dose of AOM and continuing for the 5 weeks of the study. Hence, unlike the other two retinoids, 2-CPR, although very potent in preventing ACF, enhanced rather than prevented AOM-induced colon cancer. Furthermore, our results suggest that the effect of 2-CPR on tumor yield is different from 4-HPR and 9-cis-RA because, unlike them, it does not enhance apoptosis. (+info)
NIH Guide: PIVOTAL CLINICAL TRIALS FOR CHEMOPREVENTION AGENT DEVELOPMENT
Brevet US6906129 - Polymer scale preventive agent - Google Brevets
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carbinol
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Etomoxir
The University of Colorado currently holds patents for the use of etomoxir as an anti-inflammatory and anticarcinogenic agent. ... Etomoxir and a 2-deoxy-D-glucose Compound; Antiinflammatory, Antiproliferative, Anticarcinogenic and Wound Healing Agents; Drug ...
Dacemazine
Triggle DJ, Ganellin CR, MacDonald F (1996). Dictionary of Pharmacological Agents. 1. Boca Raton: Chapman & Hall/CRC. p. 711. ... Karolyhazy G, Havas I, Jansco G, Kapas L, Sellei C (August 1952). "[The anticarcinogenic effect of dimethylaminoacetyl- ...
Semicarbazide-cadmium therapy
As a stress agent, inducing apoptosis and blocking it, Cd can have both helpful and harmful effects. Hydrazine sulfate ... It can also be anti-carcinogenic under certain conditions. At low concentrations, cadmium is able to stimulate the immune ...
Embelin
... of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin ...
Terminalia catappa
The leaves may contain agents for prevention of cancers (although they have no demonstrated anticarcinogenic properties) and ...
Myricetin
It has also been shown that myricetin can itself act as an agent of mutagenicity. Myricetin can produce frameshift mutations in ... Clearly there is a multifaceted, complex system involved in the anticarcinogenic activity displayed by myricetin that does not ... Basli A, Soulet S, Chaher N, Merillon JM, Chibane M, Monti JP, Richard T (July 2012). "Wine polyphenols: potential agents in ... Myricetin's pro-oxidative capabilities can also be seen in its ability to act as an inhibitory agent against glutathione ...
Benzaldehyde
It is accepted in the European Union as a flavoring agent. Toxicology studies indicate that it is safe and non-carcinogenic in ... the concentrations used for foods and cosmetics, and may even have anti-carcinogenic (anti-cancer) properties. For a 70 kg ... Synthetic benzaldehyde is the flavoring agent in imitation almond extract, which is used to flavor cakes and other baked goods ...
Solkadhi
... is a great antioxidant that works like an anticarcinogenic and anti-aging agent. It is known for its digestive, refreshing, ...
Index of oncology articles
... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... anticarcinogenic - anticoagulant - anticonvulsant - antidepressant - antiemetic - antiestrogen - antifolate - antifungal ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ... adjunct agent - adjunctive therapy - adjuvant therapy - adrenocortical - Adriamycin - adult T-cell leukemia/lymphoma - AE-941 ...
List of vegetable oils
Used as a drying agent in paints and varnishes. Tung oil, used as an industrial lubricant and highly effective drying agent. ... Of current research interest for its potential anti-carcinogenic properties. Bottle gourd oil, extracted from the seeds of the ... Dammar oil, from the Canarium strictum, used in paint as an oil drying agent. Can also be used as a lamp oil. Linseed oil's ... Used as a flavoring agent and in aromatherapy. Orange oil, like lemon oil, cold pressed rather than distilled. Consists of 90% ...
Microsporum nanum
Griseofulvin, clotrimazole and miconazole are antimycotic agents that are used to treat M. nanum and T. rubrum. Of three human ... antimutagenic and anticarcinogenic activities. Both neem seed and neem leaves are capable of killing M. nanum. The minimum ... Like many other dermatophytes, M. nanum is tolerant of the antifungal agent cycloheximide. In addition, M. nanum also exhibits ...
Anticarcinogen
... s are different from anticarcinoma agents (also known as anticancer or anti-neoplastic agents) in that ... Confirmation that a substance possesses anticarcinogenic activity requires extensive in vitro, in vivo, and clinical ... An anticarcinogen (also known as a carcinopreventive agent) is a substance that counteracts the effects of a carcinogen or ... anticarcinoma agents are used to selectively destroy or inhibit cancer cells after cancer has developed. Interest in ...
Ginsenoside Rb1
GRb1 and GRg1 are proposed to represent potentially effective therapeutic agents for spinal cord injuries. The protection that ... and has a variety of potential health effects including anticarcinogenic, immunomodulatory, anti‐inflammatory, antiallergic, ...
Taraxerol
... also exhibits anti-carcinogenic activity. In vivo two-stage carcinogenesis tests of mouse skin tumor showed that ... "Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer's disease: Effects against scopolamine and ... "Anti-carcinogenic Activity of Taraxacum Plant. II". Biological & Pharmaceutical Bulletin. 22 (6): 606-610. doi:10.1248/bpb. ...
Mutagen
Alkylating agents such as cyclophosphamide and cisplatin, as well as intercalating agent such as daunorubicin and doxorubicin ... Antioxidants are an important group of anticarcinogenic compounds that may help remove ROS or potentially harmful chemicals. ... Infectious agents have been suggested to cause cancer as early as 1908 by Vilhelm Ellermann and Oluf Bang, and 1911 by Peyton ... Alkylating agents such as ethylnitrosourea. The compounds transfer methyl or ethyl group to bases or the backbone phosphate ...
Tomatine
Arneson, P. A., and R. D. Durbin.; Studies on the mode of action of tomatine as a fungitoxic agent.; Plant physiology 43.5, ... Friedman, Mendel (2013). "Anticarcinogenic, Cardioprotective, and Other Health Benefits of Tomato Compounds Lycopene, α- ... Arneson, P.A., Durbin, R.D.; Studies on the Mode of Action of Tomatine as a Fungitoxic Agent.; USDA Pioneering Research ... Tomatidine is a natural small molecule inhibitor of skeletal muscle atrophy, and a potential therapeutic agent for aging- ...
P53 upregulated modulator of apoptosis
p53, and with it PUMA, is activated due to DNA damage caused by a variety of genotoxic agents. Other agents that induce p53 ... Athar M, Back JH, Kopelovich L, Bickers DR, Kim AL (June 2009). "Multiple molecular targets of resveratrol: Anti-carcinogenic ... Therapeutic agents targeting PUMA for cancer patients are emerging. PUMA inducers target cancer or tumor cells, while PUMA ... Yu J, Yue W, Wu B, Zhang L (May 2006). "PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation". Clin. ...
Decaffeination
"Chemical agents and related occupations, Volume 100F. A review of human carcinogens" (PDF). International Agency for Research ... but also because they have been shown to have anticarcinogenic, antimutagenic, antioxidative, and antimicrobial properties. ...
Co-carcinogen
A chemical may both have anti-carcinogenic properties and yet still be a co-carcinogen in combination with some carcinogens. ... a cancer chemopreventive agent or a co-carcinogen?". Mutation Research/Reviews in Mutation Research. 543 (3): 195-200. doi: ... carcinogens or anti-carcinogenic. In recent years, people substitutes health supplement for healthy meal.[citation needed] Some ...
Gary H. Posner
Posner's recent research has been focused on applying organic synthesis to the preparation of novel medicinal agents including ... correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes". Journal of Medicinal Chemistry ...
List of MeSH codes (D27)
... anticarcinogenic agents MeSH D27.505.954.248.144 - antimetabolites, antineoplastic MeSH D27.505.954.248.147 - antimitotic ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
Cockroach farming
The School of Pharmacy and Chemistry at the Dali University has published papers regarding the anti-carcinogenic properties of ... Animals living in polluted environments are potential source of antimicrobials against infectious agents. ncbi.nlm.nih.gov. ...
Lactoferrin
"Antimicrobial Agents and Chemotherapy. 47 (1): 262-7. doi:10.1128/AAC.47.1.262-267.2003. PMC 149030. PMID 12499200.. ... Anticarcinogenic activityEdit. The anticancer activity of bovine lactoferrin (bLF) has been demonstrated in experimental lung, ... "Antimicrobial Agents and Chemotherapy. 48 (4): 1242-8. doi:10.1128/AAC.48.4.1242-1248.2004. PMC 375254. PMID 15047526.. ... "Antimicrobial Agents and Chemotherapy. 47 (8): 2619-23. doi:10.1128/AAC.47.8.2619-2623.2003. PMC 166093. PMID 12878528.. ...
Pea protein
Saponins and phytates, which may exhibit hypocholesterolaemic and anticarcinogenic activities. Trypsin inhibitors decrease the ... foaming agent, or an emulsifier. It is extracted in a powder form and can be processed and produced in different ways: As an ...
Genistein
This effect may be responsible for both anticarcinogenic and carcinogenic potential of the substance. It was found to ... Antimicrobial Agents and Chemotherapy. 50 (11): 3770-8. doi:10.1128/AAC.00578-06. PMC 1635224. PMID 16954323. Si, Hongwei; Liu ... of Combination Effects for the Induction of Micronuclei in Mouse Lymphoma Cells by Binary Mixtures of the Genotoxic Agents MMS ...
Gingerol
The anti-carcinogenic activity of [6]-gingerol and [6]-paradol was analysed in a study observing the cellular mechanisms ... June 2019). "Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents". Nutrients. 11 (7): ...
Methaneseleninic acid
Implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine". Nutrition and Cancer. 40 ( ... that methaneseleninic acid shows promise as a sensitizing agent for apoptosis induced by the Bcl-2-family inhibitor ABT-737 in ...
ผู้ใช้:Rawadeeb/กระบะทราย2
Onions are a staple in Indian cuisine, often used as a thickening agent for curries and gravies. Onions pickled in vinegar are ... antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepalclc7 cells". ...
Co-carcinogen
A chemical may both have anti-carcinogenic properties and yet still be a co-carcinogen in combination with some carcinogens. ... a cancer chemopreventive agent or a co-carcinogen?". Mutation Research/Reviews in Mutation Research. 543 (3): 195-200. doi: ... carcinogens or anti-carcinogenic. In recent years, people substitutes health supplement for healthy meal.[citation needed] Some ...
topic:"Anticarcinogenic Agents - administration & dosage - metabolism" found 1 record • Arctic Health
Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti...
... of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin ... Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents.. *Oliver Werz, Jana Gerstmeier, Ulrike ... of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin ... Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) possesses anti-inflammatory and anti-carcinogenic properties in vivo, and ...
Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 by the anti-carcinogenic and anti...
Principles of chemoprevention /
Research on the anticarcinogenic activation of Acorus calcamus. Anticarcinogenic activation of alpha-asarone on human carcinoma...
Anticarcinogenic activation of alpha-asarone on human carcinoma cells] ... Research on the anticarcinogenic activation of Acorus calcamus. ... Antineoplastic Agents, Phytogenic / pharmacology* * Cell Line * ... Research on the anticarcinogenic activation of Acorus calcamus. Anticarcinogenic activation of alpha-asarone on human carcinoma ...
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Results of search for 'su:{Anticarcinogenic agents}'
Saffron | GreenMedInfo | Substance | Natural Medicine | Alternative
Cancer chemoprevention with dietary phytochemicals. - PubMed - NCBI
Anticarcinogenic Agents. LinkOut - more resources. Full Text Sources. *Nature Publishing Group. Other Literature Sources. * ... Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently ... Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from ...
Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates - Full Text View - ClinicalTrials.gov
Egcg, a dyrk1a Inhibitor as Therapeutic Tool for Reversing Cognitive Deficits in Down Syndrome Individuals. - Full Text View -...
A Pharmacokinetic Study of Genistein, a Tyrosine Kinase Inhibitor - Full Text View - ClinicalTrials.gov
Dietary Histone Deacetylase Inhibitors (HDAC) - Full Text View - ClinicalTrials.gov
Vegetables, fruit, and cancer prevention: a review. - PubMed - NCBI
RCSB PDB - STL Ligand Summary Page
Anticarcinogenic properties of medium chain fatty acids on human colorectal, skin and breast cancer cells in vitro
Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands |...
The anti-carcinogenic activity of HB-19 is encouraging, as is that of aptamer AS1411. The binding affinity (Kα value) of HB-19 ... Anticancer Agents Med Chem 11(1):4-18CrossRefPubMedGoogle Scholar ... Anti-HIV infection, anti-carcinogenic activity. Nisole et al. ( ... Anti-carcinogenic activity of HB-19 was next examined using rhabdoid tumor cell line G401 derived from Wilms tumor in nude ... Among anti-carcinogenic ligands, HB-19 pseudopeptide is a potent inhibitor of HIV infection where it acts by blocking virus ...
Squash (Winter): Compounds Support the Immune System - American Institute for Cancer Research
Mechanisms of Anticarcinogenic Componentsfrom Cruciferous Vegetables 94B02:. Role of Dietary Carotenoids as Anti-Cancer Agents ... solation and Identification of Anticarcinogenic Minor Dietary Component. 94A76:. Modulation of Anticarcinogenic Activities of ... Mechanism of Action of Indole-3-Carbinol, a Dietary Chemopreventive Agent in Breast Cancer. ...
Molecules | Free Full-Text | Anticarcinogenic Effect of Spices Due to Phenolic and Flavonoid Compounds-In Vitro Evaluation on...
Munirathinam, G.; Gray, K. Cinnamaldehye, a dietary flavoring agent derived from cinnamon targets prostate cancer cells. Endocr ... Of the eight kinds of spice tested in this work, studies on the anticarcinogenic effect on prostate cancer cells have been ... Anticarcinogenic Effect of Spices Due to Phenolic and Flavonoid Compounds-In Vitro Evaluation on Prostate Cells ... Could they be considered to be one of the major sources of anticarcinogenic compounds because they contain antioxidants and ...
Caffeic Acid | GreenMedInfo | Substance | Natural Medicine
Pharmacological Actions : Anticarcinogenic Agents. [+] Effect of caffeic acid on ischemia-reperfusion-induced acute renal ... An extract of Prunella vulgaris could be a potential therapeutic agent to ameliorate type 1 diabetes and related complications. ... Caffeic acid may be an effective chemoprotective agent for protecting liver damage against oxidative damage.Jun 19, 2019. ... Pharmacological Actions : Antioxidants, Chemoprotective Agents, Hepatoprotective. Problem Substances : Tertiary butyl ...
Kefir | GreenMedInfo | Substance | Natural Medicine | Alternative
Pharmacological Actions : Anticarcinogenic Agents, Antimutagenic Agents, Antioxidants. [+] L. kefiri P-IF represents a novel ... Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Gastrointestinal Agents, Interferon Gamma Reducer ... Pharmacological Actions : Anti-Inflammatory Agents, Antihypertensive Agents, Gastrointestinal Agents, Interleukin-6 ... Pharmacological Actions : Anti-Inflammatory Agents, Gastrointestinal Agents, Hepatoprotective, Interleukin-6 Downregulation. ...
Oral Cancer: Prevention | GreenMedInfo | Disease | Natural Medicine
Pharmacological Actions : Anti-Inflammatory Agents, Anticarcinogenic Agents, Antiproliferative , Apoptotic, Bcl-2 protein down- ... Pharmacological Actions : Angiogenesis Inhibitors, Anti-Inflammatory Agents, Anticarcinogenic Agents, MicroRNA modulator, NF- ... Pharmacological Actions : Anticarcinogenic Agents, Antiproliferative , Apoptotic, Chemopreventive. Additional Keywords : Plant ...
Clove: Uses, Side Effects, Interactions, Dosage, and Warning
Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View ... Int.J Antimicrob.Agents 1999;12(3):257-262. View abstract.. *Azuma, Y., Ozasa, N., Ueda, Y., and Takagi, N. Pharmacological ... Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract ...
Clavo de Olor: MedlinePlus suplementos
Sesquiterpenes from clove (Eugenia caryophyllata) as potential anticarcinogenic agents. J Nat Prod 1992;55:999-1003. View ... Int.J Antimicrob.Agents 1999;12:257-262. View abstract.. * Soetiarto, F. The relationship between habitual clove cigarette ... Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88:308-16. View abstract ...
Etomoxir - Wikipedia
Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies.
Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of...
... and suppression of gastric acidity with acid-reducing agents could impair their absorption. In addition, a maj ... Anticarcinogenic Agents / pharmacokinetics, therapeutic use*. Drug Interactions. Gastric Acid. Gastric Acidity Determination. ... Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of ... In addition, a majority of cancer patients frequently take acid-reducing agents to alleviate symptoms of gastroesophageal ...
MEDLINE - Resultado p gina 1
0 (Anticarcinogenic Agents); 0 (Phytoestrogens). [Em] M s de entrada:. 1709. [Cu] Atualiza o por classe:. 170911. ... 0 (Angiogenesis Inducing Agents); 0 (Estrogen Receptor beta); 0 (Iridoid Glucosides); 0 (Phytoestrogens); 0 (Platelet ... 0 (Antineoplastic Agents, Phytogenic); 0 (Butylene Glycols); 0 (Isoflavones); 0 (Lignans); 0 (Phytoestrogens); 6287WC5J2L ( ... involves the use of specific natural products or synthetic chemical agents to overturn, repress, or prevent pre-malignancy ...
MEDLINE - Resultado p gina 1
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Anticarcinogenic Agents); 0 (Carcinogens); 87299V3Q9W (Azaserine); R16CO5Y76E ( ... Treatment of wild-type mice with O-GlcNAcylation-inducing agents reverses AMPK action. Finally, we demonstrate that AMPK ... Conversely, O-GlcNAcylation-inducing agents counteract the anti-hypertrophic effect of AMPK. In vivo, AMPK activation prevents ...
Nutritional and Toxicological Aspects of Food Safety | SpringerLink
Described the anticarcinogenic activityAntioxidantSilymarinPotentAntitumorChemopreventive agentsTumorigenesisTherapeutic agentAntiviralPutativeAntimicrobialBioavailabilityActionsSaffronFlavonoidEffectsInhibitorsChemotherapeuticPolyphenolsGreen teaMelanomaMedicinal ChemistryEffectPotentialSubstanceMechanismsCancersAdversePropertiesMolecularTumor promotionActivityChemicalClinicalTopicallyConclusionCompoundAntioxidantsResearchChemopreventionOrallyModulateProtective AgentsEvidenceCellsReviewDiseasesTopical agentsCancer
Described the anticarcinogenic activity1
- first described the anticarcinogenic activity of SOD mimetics already in 1983 ( 5 ). (aacrjournals.org)
Antioxidant11
- Caffeic Acid has significant potential as an antidiabetic agent via attenuation of glucose output, increased glucose uptake, increased insulin secretion and antioxidant capacity. (greenmedinfo.com)
- Silymarin, a flavonoid antioxidant isolated from milk thistle, exerts exceptionally high to complete anticarcinogenic effects in tumorigenesis models of epithelial origin. (aacrjournals.org)
- Without mentioning our original work, they stated: "Considering the structure of Mangafodipir trisodium (MnDPDP), a contrast agent currently used in MR imaging of the liver neoplasm, we hypothesized that this molecule could also exert an antioxidant activity and be possible used as treatment of APAP-induced ALF. (aacrjournals.org)
- The green tea polyphenols (GTP) possess not only antioxidant activity, but they also act as anti-inflammatory and anticarcinogenic agents. (medscape.com)
- Flavonoids possess antioxidant, anti-inflammatory and anticarcinogenic properties and have been studied as chemopreventive agents in human cancer therapy. (mdpi.com)
- In conclusion the CGA extract was successfully prepared and proved to have antioxidant, antimicrobial and anticarcinogenic properties. (scialert.net)
- Because silymarin has been described to be an antioxidant with anti-inflammatory, cytoprotective, and anticarcinogenic effects, we tested the hypothesis that these effects are mediated through its modulation of activation of NF-κB, members of the MAPK, and caspase-mediated apoptosis. (jimmunol.org)
- 5. Blackberries have a substantial quantity of phenolic acids which are antioxidant compounds known as anti-carcinogenic agents. (amoils.com)
- The anticarcinogenic potential of milk fat can be attributed to its antioxidant, anti-inflammatory, immunostimulatory properties as well as the presence of compounds with antimutagenic effects. (aaem.pl)
- Botanical supplements, specifically dietary botanicals, possessing anti-inflammatory, immunomodulatory, and antioxidant properties are among the most promising group of compounds that can be exploited as ideal chemopreventive agents for skin cancer prevention. (herbs.org)
- Triterpenoids have been used for medicinal purposes in many Asian countries because of their anti-inflammatory, antioxidant, antiproliferative, anticancer, and anticarcinogenic properties. (dovepress.com)
Silymarin13
- In this study, we investigated the anticarcinogenic effect of silymarin and associated molecular mechanisms, using human breast carcinoma cells MDA-MB 468. (aacrjournals.org)
- Taken together, these results suggest that silymarin may exert a strong anticarcinogenic effect against PCA and that this effect is likely to involve impairment of erbB1-SHC-mediated signaling pathway, induction of CDKIs, and a resultant G 1 arrest. (aacrjournals.org)
- Silymarin has been shown to be a potent anticarcinogenic agent. (aacrjournals.org)
- In recent years, silymarin has also been used in Asia as a therapeutic agent for liver diseases ( 6 ). (aacrjournals.org)
- Silymarin acts as a potent anticarcinogenic agent against in vitro and in vivo carcinogenesis experiments ( 12 - 14 ). (aacrjournals.org)
- Silymarin is a polyphenolic flavonoid derived from milk thistle ( Silybum marianum ) that has anti-inflammatory, cytoprotective, and anticarcinogenic effects. (jimmunol.org)
- In this report, we investigated the effect of silymarin on NF-κB activation induced by various inflammatory agents. (jimmunol.org)
- Overall, the inhibition of activation of NF-κB and the kinases may provide in part the molecular basis for the anticarcinogenic and anti-inflammatory effects of silymarin, and its effects on caspases may explain its role in cytoprotection. (jimmunol.org)
- By inhibiting lipid peroxidation, silymarin protects against hepatic toxicity induced by a wide variety of agents ( 7 , 8 , 9 , 10 , 11 ). (jimmunol.org)
- Besides its hepatoprotective principle, silymarin is a potent chemopreventive agent ( 13 , 14 , 15 ). (jimmunol.org)
- How silymarin mediates its anticarcinogenic effects is not fully understood, but it has been shown that some of the effects are mediated through inhibition of receptor tyrosine kinases ( 16 ), cyclin-dependent kinases ( 17 , 18 ), TNF mRNA expression ( 19 ), and ornithine decarboxylase activity ( 13 ). (jimmunol.org)
- Besides anticarcinogenic effects, silymarin also exerts anti-inflammatory action in vivo ( 20 ). (jimmunol.org)
- Because silymarin exhibits anticarcinogenic, anti-inflammatory, and growth-modulatory effects, much as TNF does, we hypothesized that these effects of silymarin are mediated through suppression of NF-κB activation, the mediator of many of the TNF effects. (jimmunol.org)
Potent6
- Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. (semanticscholar.org)
- article{Schaible2013PotentIO, title={Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. (semanticscholar.org)
- There is an increasing interest in identifying potent cancer preventive and therapeutic agents against breast cancer. (aacrjournals.org)
- Regarding CBD, ruderalis is rich in this active cannabinoid which is now being widely recognized for its non-psychoactive medical properties which are highly beneficial in reducing inflammation , managing pain, and are believed to very potent anti-cancer agents. (bibliotecapleyades.net)
- Sodium butyrate (butyrate) is a potent growth inhibitor and differentiating agent for many cell types, including breast cancer cells. (aacrjournals.org)
- Bowman KJ, White A, Golding BT, Griffin RJ and Curtin NJ (1998) Potentiation of anti‐cancer agent cytotoxicity by the potent poly(ADP‐ribose) polymerase inhibitors NU1025 and NU1064. (els.net)
Antitumor2
- On the other hand, since chronic inflammation is a well-recognized condition that promotes tumor development, it appears that autoimmunity can be a "double agent" in mediating either pro-tumor or antitumor effects. (frontiersin.org)
- β-Ionone is found to exert anticarcinogenic and antitumor activities in melanoma, meningioma cells, and breast cancer ( 12 - 17 ). (aacrjournals.org)
Chemopreventive agents4
- Experimentally, aflatoxin -induced hepatocarcinogenesis can be inhibited by over a score of different chemopreventive agents with multiple mechanisms of action. (curehunter.com)
- Both chemopreventive agents modulated levels of aflatoxin biomarkers in the study participants in manners consonant with protection. (curehunter.com)
- α-Mangostin, a natural xanthone isolated from the pericarps of mangosteen, represents one of the most studied chemopreventive agents. (researchgate.net)
- The development of effective chemopreventive agents that can reduce or control the risk of UV-induced skin cancer is required to address this pressing public health issue. (herbs.org)
Tumorigenesis2
- Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. (nih.gov)
- For example, various agents that promote tumorigenesis are known to activate NF-κB ( 21 ), including phorbol ester, okadaic acid, and TNF. (jimmunol.org)
Therapeutic agent3
- An extract of Prunella vulgaris could be a potential therapeutic agent to ameliorate type 1 diabetes and related complications. (greenmedinfo.com)
- In this study, the previously implicated hepatoprotective function of the PN extract was further evaluated and its efficacy as a therapeutic agent was experimentally tested on a rat model of liver cirrhosis induced chemically by thioacetamide (TAA) administration. (hindawi.com)
- Vitamin D helps promote healthy cellular differentiation, and several lines of data highlight vitamin D's potential as a preventive and therapeutic agent in a variety of cancers, including leukemia. (lifeextension.com)
Antiviral1
- When re-utilised, these chemicals and nutrients act as natural vaccines, antibacterial, antiviral and anticarcinogenic agents as well as hormone balancers and allergy relievers. (rexresearch.com)
Putative1
- Its putative role as an anticarcinogenic agent is just beginning to be widely appreciated. (naturalmedicinejournal.com)
Antimicrobial2
- All chosen extracts showed potential as antimicrobial and anticarcinogenic agents. (scialert.net)
- 5 Chemotherapeutic agents have been used commonly as adjuncts but increasing incidence of failure and the development of resistance to conventional antibiotics has led to the screening of several medicinal plants for their potential antimicrobial activity and host modulating effects. (scielo.org.za)
Bioavailability2
- The Stereochemistry and Asymmetric Synthesis Group at the Faculty of Pharmacy at the University of Seville, in collaboration with the Asymmetric Synthesis and Functional Nanosystems Group at the Chemical Research Institute of cicCartuja, have managed to synthesize active, stable derivatives with high bioavailability of a compound with anticarcinogenic properties, also used in the treatment of other diseases. (news-medical.net)
- Well-designed trials are required to delineate the potential clinical usefulness of these agents through issues, such as determining the optimal period and route of administration, systemic bioavailability, optimal dosing and toxicity of the agent, and single or combinatorial approach. (aacrjournals.org)
Actions1
- Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals. (nih.gov)
Saffron2
- Protective effect of saffron ( Crocus sativus L.) aqueous extract against genetic damage induced by anti-tumor agents in mice. (lifeextension.com)
- These findings, together with our previous results, suggest a potential role for saffron as an anti-genotoxic, anti-oxidant and chemopreventive agent and could be used as an adjuvant in chemotherapeutic applications. (lifeextension.com)
Flavonoid1
- Silibinin is a milk thistle flavonoid that possesses anticarcinogenic effect against many epithelial cancers. (aacrjournals.org)
Effects4
- Systemic or oral protective agents in the form of supplementation, preventing free radicals formation and its harmful effects would be an alternative option for photoprotection. (intechopen.com)
- Several researches have studied the effects of oral agents to show the protective abilities against UV exposure. (intechopen.com)
- Cardioprotective effects of the magnetic resonance imaging agent manganese dipyridoxyl diphosphate and its metabolite manganese dipyridoxyl ethyldiamine upon reperfusion of the ischemic porcine myocardium. (aacrjournals.org)
- Mukhtar H., Katiyar S., Agarwal R. (1994) Green Tea and Skin--Anticarcinogenic Effects. (patentgenius.com)
Inhibitors2
- Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents. (semanticscholar.org)
- Bentle MS, Bey EA, Dong Y, Reinicke KE and Boothman DA (2006) New tricks for old drugs: the anticarcinogenic potential of DNA repair inhibitors. (els.net)
Chemotherapeutic3
- Thus, SAC can be considered as a potential chemotherapeutic agent for the prevention and treatment of cancer. (koreascience.or.kr)
- In order to optimize the conditions of this compound as a chemotherapeutic and chemopreventive agent, for instance in diseases such as cancer, obesity, diabetes as well as inflammatory disorders, the recent tendency is to limit the range of its pharmacological properties. (researchgate.net)
- Curcumin was not only found to be a potential anticarcinogenic agent, but it was also reported to enhance the efficacy of chemotherapeutic drugs. (ijpsonline.com)
Polyphenols3
- In this review, we have summarized the recent investigations and mechanistic studies on CaP chemoprevention using dietary agents, such as selenium, vitamins D and E, lycopene, phytoestrogens, flavonoids, and green tea polyphenols. (aacrjournals.org)
- A study reported in the Journal of Nutrition demonstrated the promise of green tea polyphenols as anticarcinogenic agents to prevent the development of solar ultraviolet radiation induced skin cancer. (herbs.org)
- Green tea polyphenols (GTPs) show promise as anticarcinogenic agents and may prevent the development of solar UV radiation-induced skin cancer. (herbs.org)
Green tea1
- Plant-derived agents include beta-carotene, green tea, golden serpent fern, tomato, cocoa bean, and vitamin E, whereas animal-derived products consist of nicotinamide and omega-3 polyunsaturated fatty acids. (intechopen.com)
Melanoma1
- Although many environmental and genetic factors contribute to the development of skin cancers, epidemiologic, clinical and biological studies have established that chronic exposure to UV radiation is a well-recognized etiological agent for both nonmelanoma and melanoma skin cancers, and accounts for ~1.3 million new cases of skin cancers each year in the United States (1). (herbs.org)
Medicinal Chemistry2
- All chemists and scientists will welcome Anti-Cancer Agents in Medicinal Chemistry as a fresh and vital source of information for this important field. (eurekaselect.com)
- In general I am very pleased to be one of the scientists to have published research in Anticancer Agents in Medicinal Chemistry - Bentham Science. (eurekaselect.com)
Effect1
- Conversely, O-GlcNAcylation-inducing agents counteract the anti-hypertrophic effect of AMPK. (bireme.br)
Potential4
- In addition, a majority of cancer patients frequently take acid-reducing agents to alleviate symptoms of gastroesophageal reflux disease, thereby raising the potential for a common but underappreciated drug-drug interaction (DDI) that could decrease the exposure of anticancer medication and result in subsequent failure of therapy. (biomedsearch.com)
- It exhibits strong potential as a topical agent for wound repair, especially issues caused by radiation. (veterinarypracticenews.com)
- Nature is an attractive source of new therapeutic candidate compounds as a tremendous chemical diversity is found in millions of species of plants, animals, marine organisms, and microorganisms as potential medicinal agents. (springer.com)
- Clove and its derivatives have a definite potential to be used as specific anti-plaque and anti-inflammatory agents for the treatment of periodontal disease. (scielo.org.za)
Substance1
- A method of imparting anti-AIDS virus activities by sulfation to a substance having no such activities, is now being used as a technique for developing an anti-AIDS virus agent. (google.com)
Mechanisms1
- A number of mechanisms have been proposed for its anticarcinogenic activities. (researchgate.net)
Cancers1
- Rosemary is a popular herb known to act as a preventive agent against cardiovascular disease, diabetes and different types of cancers. (sooperarticles.com)
Adverse1
- This agent is generally well tolerated, but it may increase adverse cardiovascular events. (dovepress.com)
Properties3
- Manganese dipyridoxyl diphosphate: MRI contrast agent with antioxidative and cardioprotective properties? (aacrjournals.org)
- Vaccenic acid, CLA and sphingomyelin possess antimutagenic and anticarcinogenic properties. (aaem.pl)
- Other beneficial properties include improved immunity, prevention of respiratory disorders, and anti-carcinogenic agent. (coherentmarketinsights.com)
Molecular1
- An anti-AIDS virus agent comprising a sulfate of a polysaccharide having repeating units of the formula: ##STR1## and having a molecular weight of at most 1,000,000 (n≦1544). (google.com)
Tumor promotion1
- The activation of MAPKs by tumor-promoting agents plays a major role in tumor promotion and malignant transformation ( 8 , 15 , 16 ). (aacrjournals.org)
Activity3
- S-allylcysteine (SAC) is an aged garlic derived water soluble organosulfur compound and has been suggested to have anticarcinogenic activity against diverse types of cancer cells. (koreascience.or.kr)
- Pomegranate, widely recognized for its strong anti-oxidant activity, may foster skin regeneration through agents derived from the peel and seeds. (veterinarypracticenews.com)
- Many researchers investigated the anticarcinogenic activity of curcumin in animal models. (ijpsonline.com)
Chemical1
- 3 However, this conventional treatment strategy is not always successful and the addition of chemical agents as an adjunct has been suggested to enhance efficacy in achieving better oral health. (scielo.org.za)
Clinical2
- This article is a review of the available clinical literature describing the extent of the interaction between 15 orally administered, small-molecule targeted anticancer therapies and acid-reducing agents. (biomedsearch.com)
- From total 24 clinical trials with 850 participants, two categories of naturally derived agents were identified. (intechopen.com)
Topically2
- Research has shown that a number of plant-based agents do actually benefit the skin when applied topically. (veterinarypracticenews.com)
- Drawbacks of Chinese mystery mixtures aside, research has shown that a number of plant-based agents do actually benefit the skin when applied topically. (veterinarypracticenews.com)
Conclusion1
- In conclusion, systemic plant and animal-derived photoprotective agents may be a promising alternative in addition to conventional photoprotection. (intechopen.com)
Compound1
- This compound is an analogue of sulforaphane (SFN), a compound which was isolated for the first time in 1992 from broccoli extracts and which is considered by the National Cancer Institute in the United States as one of the forty most promising anti-cancer agents. (news-medical.net)
Antioxidants1
- The antioxidants present in corn act as a anti-carcinogen agents and can help prevent Alzheimer's disease. (ingredientsinc.net)
Research2
- Research on the anticarcinogenic activation of Acorus calcamus. (nih.gov)
- Research, however, showed conflicting results on the effectiveness of this beverage as an anticarcinogenic agent. (cancernetwork.com)
Chemoprevention2
- It is hoped that, combining the knowledge based on agents with targets, effective approaches for CaP chemoprevention can be established. (aacrjournals.org)
- Agents that modulate UVB- and EGF-mediated signaling pathways could be of use in the chemoprevention of skin cancer. (aacrjournals.org)
Orally1
- A majority of the novel orally administered, molecularly targeted anticancer therapies are weak bases that exhibit pH-dependent solubility, and suppression of gastric acidity with acid-reducing agents could impair their absorption. (biomedsearch.com)
Modulate1
- Through Keap1/Nrf2 and nuclear factor-κB pathways, this agent can modulate the activities of a number of important proteins that regulate inflammation, redox balance, cell proliferation and programmed cell death. (dovepress.com)
Protective Agents2
- Physical and topical protective agents are the standard photoprotective strategies especially after dermatologic surgery. (intechopen.com)
- In addition, topical protective agents may cause allergic reactions on some individuals [ 2 ]. (intechopen.com)
Evidence1
- This chapter will thoroughly review photoprotective outcomes of oral naturally derived agents from randomized controlled trials using evidence-based method. (intechopen.com)
Cells1
- Fishel ML, He Y, Smith ML and Kelley MR (2007) Manipulation of base excision repair to sensitize ovarian cancer cells to alkylating agent temozolomide. (els.net)
Review1
- Also, the review highlights the various pathogenic species of Colletotrichum spp, the causal agent of the disease, associated with the host crop in the country. (frontiersin.org)
Diseases1
- All this makes it one of the epigenetic agents that offers the greatest protection in the treatment of many diseases. (news-medical.net)
Topical agents1
- Inadequate physical protection, amount of topical application, and allergic reactions to topical agents are limitations associated with current photoprotective strategies. (intechopen.com)
Cancer5
- Metformin suppressed the polyp growth in Apc(Min/+) mice, suggesting that it may be a novel candidate as a chemopreventive agent for colorectal cancer. (nih.gov)
- Our procedure can serve as a simplified alternative method for the preparation of BBI which is being used as a cancer chemoprotective agent. (usda.gov)
- Since soybean seeds release large amounts of enzymatically active BBI when immersed in warm water our procedure could be exploited as a simplified alternative method for the preparation of BBI concentrate which is being used as a cancer chemoprotective agent. (usda.gov)
- Anti-cancer agents in milkfat. (aaem.pl)
- An integrative approach that, in addition to optimizing lifestyle, employs specific natural agents can safely and effectively enhance energy levels after conventional cancer treatments. (naturalmedicinejournal.com)