AnatomyChemicals and DrugsPhenomena and Processes
Antibody-Dependent EnhancementAntibody-Dependent Cell CytotoxicityAntibodies, MonoclonalAntibodiesImmunoglobulin GKiller Cells, NaturalCytotoxicity, ImmunologicAntibody Specificity
Antibody-Dependent Enhancement
Enhancement of viral infectivity caused by non-neutralizing antibodies. There are at least two mechanisms known to account for this: mediation by Fc receptors (RECEPTORS, FC) or by complement receptors (RECEPTORS, COMPLEMENT). Either the virus is complexed with antiviral IMMUNOGLOBULIN G and binds to Fc receptors, or virus is coated with antiviral IMMUNOGLOBULIN M and binds to complement receptors.
Antibody-Dependent Cell Cytotoxicity
The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Antibodies
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Immunoglobulin G
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Cytotoxicity, Immunologic
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Antibody Specificity
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

In vitro antibody-dependent enhancement assays are insensitive indicators of in vivo vaccine enhancement of equine infectious anemia virus. (1/83)

We have previously demonstrated a high propensity for enhancement of virus replication and disease resulting from experimental immunization of ponies with a baculovirus recombinant envelope (rgp90) vaccine from equine infectious anemia virus (EIAV). The current studies were undertaken to examine the correlation between the observed in vivo vaccine enhancement and in vitro assays for antibody-dependent enhancement (ADE) of EIAV replication. Toward this goal an optimized EIAV in vitro enhancement assay was developed using primary equine macrophage cells and used to evaluate the enhancement properties of immune serum taken from rgp90 immunized ponies that displayed various levels of vaccine enhancement after experimental challenge with EIAV. For comparison, we analyzed in parallel immune serum samples from a group of ponies immunized with a viral envelope subunit vaccine (LL-gp) that produced sterile protection from EIAV challenge. The results of these assays demonstrated that the rgp90 immune serum had a greater propensity for in vitro enhancement of EIAV replication than serum from the protected LL-gp immunized ponies; in vitro enhancement levels for the rgp90 immune sera averaged about 1.5, with a maximum enhancement value of about 2.0. While distinguishing between immune serum produced by the rgp90 and LL-gp immunizations, the in vitro enhancement assay failed to reliably correlate with the severity of in vivo enhancement observed among the rgp90 vaccine recipients. Vaccinated ponies that experienced moderate to no disease signs displayed levels of in vitro enhancement similar to those of ponies that experienced severe and fatal enhancement of disease after viral challenge. The observed in vitro enhancement was demonstrated to be dependent on serum immunoglobulin, but independent of complement. These studies demonstrate in the EIAV system that in vitro ADE assays appear to be relatively insensitive indicators of the severity of in vivo enhancement and that relatively low levels of in vitro ADE can be associated with severe to fatal enhancement of virus replication and disease in vivo. These observations suggest that relatively low levels of serum ADE observed in other lentivirus systems, including HIV-1, may have more profound effects on in vivo virus replication and disease than previously recognized.  (+info)

Infection of human cells by dengue virus is modulated by different cell types and viral strains. (2/83)

Although prior studies have investigated cellular infection by dengue virus (DV), many have used highly passaged strains. We have reassessed cellular infection by DV type 2 (DV2) using prototype and low-passage isolates representing genotypes from different geographic areas. We observed marked variation in the susceptibility to infection among cell types by different DV2 strains. HepG2 hepatoma cells were susceptible to infection by all DV2 strains assayed. Although the prototype strain generated higher titers of secreted virus than the low-passage isolates, this difference did not correspond to positive- or negative-strand viral RNA levels and thus may reflect variation in efficiency among DV2 isolates to translate viral proteins or package and/or secrete virus. In contrast, human foreskin fibroblasts were susceptible to the prototype and low-passage Thai isolates but not to five Nicaraguan strains tested, as reflected by the absence of accumulation of negative-strand viral RNA, viral antigen, and infectious virus. A similar pattern was observed with the antibody-dependent pathway of infection. U937 and THP-1 myeloid cells and peripheral blood monocytes were infected in the presence of enhancing antibodies by the prototype strain but not by low-passage Nicaraguan isolates. Again, the barrier appeared to be prior to negative-strand accumulation. Thus, depending on the cell type and viral isolate, blocks that limit the production of infectious virus in vitro may occur at distinct steps in the pathway of cellular infection.  (+info)

Specific ablation of antiviral gene expression in macrophages by antibody-dependent enhancement of Ross River virus infection. (3/83)

Ross River virus (RRV) is an indigenous Australian arthropod-borne alphavirus responsible for epidemic polyarthritis (EPA), myalgia, and lethargy in humans. Macrophages and monocytes have been associated with human RRV disease, and previous studies have shown that RRV is capable of infecting macrophages via both a natural virus receptor and by Fc receptor-mediated antibody-dependent enhancement (ADE). Similar to other viruses, such as human immunodeficiency virus and dengue virus, ADE infection results in dramatic RRV growth increases for in vitro macrophage cultures. This study demonstrates that RRV could resist lipopolysaccharide (LPS)-induced antiviral activity in macrophage cultures when infection was via the ADE pathway. Investigation of this infection pathway found that RRV was able to suppress the transcription and translation of key antiviral genes (tumor necrosis factor and inducible nitric oxide synthase) in LPS-stimulated macrophages by disrupting the transcription into mRNA of the genes coding for the associated transcription factors IRF-1 and NF-kappaB. The transcription of non-antiviral control genes was not perturbed by RRV-ADE infection, and de novo protein synthesis also was not significantly affected in RRV-ADE infected cells. The ADE pathway of infection allowed RRV to specifically target antiviral genes in macrophages, resulting in unrestricted virus replication. As ADE has been observed for several virus families and associated with disease and adverse vaccination outcomes, these findings may have broad relevance to viral disease formation and antiviral vaccination strategies.  (+info)

Infectivity-enhancing antibodies to Ebola virus glycoprotein. (4/83)

Ebola virus causes severe hemorrhagic fever in primates, resulting in mortality rates of up to 100%, yet there are no satisfactory biologic explanations for this extreme virulence. Here we show that antisera produced by DNA immunization with a plasmid encoding the surface glycoprotein (GP) of the Zaire strain of Ebola virus enhances the infectivity of vesicular stomatitis virus pseudotyped with the GP. Substantially weaker enhancement was observed with antiserum to the GP of the Reston strain, which is much less pathogenic in humans than the Ebola Zaire and Sudan viruses. The enhancing activity was abolished by heat but was increased in the presence of complement system inhibitors, suggesting that heat-labile factors other than the complement system are required for this effect. We also generated an anti-Zaire GP monoclonal antibody that enhanced viral infectivity and another that neutralized it, indicating the presence of distinct epitopes for these properties. Our findings suggest that antibody-dependent enhancement of infectivity may account for the extreme virulence of the virus. They also raise issues about the development of Ebola virus vaccines and the use of passive prophylaxis or therapy with Ebola virus GP antibodies.  (+info)

Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody. (5/83)

Although many recombinant adenovirus vectors (rAd) have been developed, especially by using group C adenoviruses, to transfer and express genes, such rAd do not readily infect B-cell lines due to the lack of the coxsackievirus-adenovirus receptor. Bispecific antibodies have been used in different cell systems to facilitate entry of rAd into otherwise nonpermissive cells. Bispecific antibody is synthesized by covalently linking two monoclonal antibodies with distinct specificities. It has been shown that lymphoproliferative tumors commonly express the cell surface protein CD70, while this receptor is normally expressed on only a small subset of highly activated B cells and T cells. We therefore investigated whether a bispecific antibody with specificities for the adenovirus fiber protein and CD70 can facilitate rAd entry and subsequent expression of rAd-encoded genes in CD70-positive B cells. We found high CD70 expression on Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines (LCLs), as well as some, but not all, Burkitt lymphoma (BL) lines. We show here that rAd encoding green fluorescent protein (Ad-GFP) infects EBV-transformed LCLs and a CD70-positive BL line 10- to 20-fold more efficiently in the presence of the CD70-fiber bispecific antibody. In contrast, the bispecific antibody does not enhance Ad-GFP infection in CD70-deficient BL cells. Using the CD70-fiber bispecific antibody, we increased the ability of rAd vectors encoding the EBV immediate-early proteins BZLF1 and BRLF1 to induce the lytic form of EBV infection in LCLs. These results indicate that the CD70-fiber bispecific antibody can enhance rAd infection of CD70-positive B cells and suggest the use of this vector to explore EBV-positive LCLs.  (+info)

Antibody-dependent enhancement of coxsackievirus B4 infectivity of human peripheral blood mononuclear cells results in increased interferon-alpha synthesis. (6/83)

IgG devoid of neutralizing activity and isolated from donor plasma by chromatography formed immune complexes with coxsackievirus B4 (CVB4) and significantly increased the infection of peripheral blood mononuclear cells with CVB4. The major host cells for CVB4 infection enhanced with IgG are monocytic CD14+ cells. The roles of CVB and adenovirus receptor and Fcgamma receptor II and III have been shown. Increased viral replication and the release of infectious particles were demonstrated when interferon (IFN)-alpha produced by infected cells was first neutralized by use of antibodies. The CVB4 IgG-induced synthesis of IFN-alpha by monocytes reflected entry and uncoating of CVB4 but not of viral replication and required the presence of CVB4 RNA inside the cells. Thus, CVB4 can infect monocytes by an antibody-dependent mechanism through interactions between the virus, antiviral antibodies, and specific receptors that result in IFN-alpha production.  (+info)

Enhancement of coxsackievirus B3 infection by antibody to a different coxsackievirus strain. (7/83)

Group B coxsackieviruses (CVBs) are a major cause of viral myocarditis and pancreatitis in humans and produce a similar pattern of disease in inbred strains of mice. As there are six strains of CVBs, individuals can be infected with multiple serotypes. This raises the possibility of antibody enhancement of infectivity (AEI) by cross-reactive but non-neutralizing antibody to a different strain from a prior infection. To determine whether AEI plays a role in coxsackievirus pathogenesis, an in vitro system using the murine macrophage cell line J774.1 was tested for enhanced infection when incubated with CVB3 plus anti-CVB2 antibody. Yields of virus were found to increase by 10-50-fold and the percentage of infected cells increased proportionately. The effect was Fc-mediated as F(ab')2 fragments of the antibody could not mediate the effect. To determine whether AEI could also be demonstrated in vivo CVB3 was injected into 5-week-old mice together with mouse polyclonal anti-CVB2. Controls included mice injected with PBS or CVB3 alone. Results showed that the titres of virus in tissues of animals injected with virus plus antibody were 1-2 logs higher than when virus was injected alone. This was accompanied by greater histopathological damage, particularly in the heart. These results have implications for human disease as infection with multiple strains likely occurs during the lifetime of an individual.  (+info)

Complement-mediated enhancement of antibody function for neutralization of pseudotype virus containing hepatitis C virus E2 chimeric glycoprotein. (8/83)

We previously reported a number of features of hepatitis C virus (HCV) chimeric glycoproteins related to pseudotype virus entry into mammalian cells. In this study, pseudotype virus was neutralized by HCV E2 glycoprotein-specific antibodies and infected human sera. Neutralization (50% reduction of pseudotype virus plaque formation) was observed with two human immunoglobulin G1 monoclonal antibodies (MAbs) at concentrations of between 2.5 and 10 microg/ml. A hyperimmune rabbit antiserum to an E2 hypervariable region 1 (HVR1) mimotope also exhibited an HCV E2 pseudotype virus neutralization titer of approximately 1/50. An E1 pseudotype virus used as a negative control was not neutralized to a significant level (<1/10) by these MAbs or rabbit antiserum to E2 HVR1. Since HCV probably has a lipid envelope, the role of complement in antibody-mediated virus neutralization was examined. Significant increases in the neutralization titers of the human MAbs (approximately 60- to 160-fold higher) and rabbit antiserum to HVR1 mimotopes (approximately 10-fold higher) were observed upon addition of guinea pig complement. Further, these studies suggested that complement activation occurred primarily by the classical pathway, since a deficiency in the C4 component led to a significant decrease in the level of virus neutralization. This same decrease was not observed with factor B-deficient complement. We also determined that 9 of 56 HCV-infected patient sera (16%) had detectable pseudotype virus neutralization activity at serum dilutions of between 1/20 and 1/50 and that complement addition enhanced the neutralization activity of some of the HCV-infected human sera. Taken together, these results suggest that during infection, HCV E2 glycoprotein induces a weak neutralizing antibody response, that those antibodies can be measured in vitro by the surrogate pseudotype virus plaque reduction assay, and that neutralization function can be augmented by complement.  (+info)

For the COVID-19 vaccine, please comment on antibody‐dependent enhancement and other potential adver | ACOEMFor the COVID-19 vaccine, please comment on antibody‐dependent enhancement and other potential adver | ACOEM
There are concerns about the potential for more serious adverse events-enhanced respiratory disease (ERD) following infection and a subtype of ERD, antibody-dependent enhancement (ADE) following infection after vaccine administration. There are two mechanisms of ADE, both of which occur when non-neutralizing antibodies or antibodies at sub-neutralizing levels bind to viral antigens without blocking or clearing infection. In ADE via enhanced infection, non-neutralizing antibodies bound to the virus enhance infection rates in target cells, such as macrophages, leading to more severe disease. In the second type described by Lee et al., ADE via enhanced immune activation, binding of non-neutralizing antibody to the virus leads to the formation of immune complexes in lung tissues, which, in turn, lead to secretion of pro-inflammatory cytokines and activation of the complement cascade. The ensuing inflammation can lead to airway obstruction and can cause acute respiratory distress syndrome in ...
http://acoem.org/COVID-19-Resource-Center/COVID-19-Q-A-Forum/For-the-COVID-19-vaccine,-please-comment-on-antibody%E2%80%90dependent-enhancement-and-other-potential-adver
Breaking News, URGENT: We Have a Literal Catastrophe - Antibody Dependent Enhancement DETECTED with COVID-19 | Health | Before...Breaking News, URGENT: We Have a Literal Catastrophe - Antibody Dependent Enhancement DETECTED with COVID-19 | Health | Before...
Persons who have been VACCINATED against COVID-19 are now subject to Antibody-Dependent Enhancement which is highly likely to . . . kill them. This is the absolute worst-case scenario with any vaccine. People who took the vax should be quarantined and isolated immediately. The
https://beforeitsnews.com/health/2021/08/breaking-news-urgent-we-have-a-literal-catastrophe-antibody-dependent-enhancement-detected-with-covid-19-3041067.html
MGCD-265 | Vitamin D-response element in the rat calcidiolMGCD-265 | Vitamin D-response element in the rat calcidiol
Background Improvement in dengue vaccine development has been hampered by limited understanding of protective immunity against dengue disease infection. samples (75%, 60/80) shown DENV neutralizing activity (PRNT5010) and infection-enhancing activity. Eleven of 18 serum samples from individuals with acute secondary DENV infection shown neutralizing activity to the infecting serotype determined by using FcR-negative BHK cells (PRNT5010), but not when determined by using FcR-expressing cells. Summary Human serum samples with low neutralizing activity determined by using FcR-negative cells showed DENV infection-enhancing activity using FcR-expressing cells, whereas those with high neutralizing activity determined by using FcR-negative cells demonstrate low or no infection-enhancing activity using FcR-expressing cells. The results suggest an inverse relationship between neutralizing antibody titer and infection-enhancing activity, which neutralizing activity dependant on using FcR-expressing cells, ...
http://calcitetrol.info/tag/mgcd-265/
Antibody-dependent enhancement - WikipediaAntibody-dependent enhancement - Wikipedia
Antibody-dependent enhancement (ADE) occurs when non-neutralising antiviral proteins facilitate virus entry into host cells, leading to increased infectivity in the cells. Some cells do not have the usual receptors on their surfaces that viruses use to gain entry. The antiviral proteins (i.e., the antibodies) bind to antibody Fc receptors that some of these cells have in the plasma membrane. The viruses bind to the antigen binding site at the other end of the antibody. ADE is common in cells cultured in the laboratory, but rarely occurs in vivo except for dengue virus. This virus can use this mechanism to infect human macrophages, causing a normally mild viral infection to become life-threatening. The most widely known example of ADE occurs in the setting of infection with the dengue virus (DENV). DENV is a single-stranded positive-polarity RNA virus of the Flaviviridae family. It causes a disease of varying severity in humans, from dengue fever (DF), which is usually self-limited, to dengue ...
https://en.wikipedia.org/wiki/Antibody-dependent_enhancement
Determination of antibody concentration as the main parameter in a dengue virus antibody-dependent enhancement assay using FcγR...Determination of antibody concentration as the main parameter in a dengue virus antibody-dependent enhancement assay using FcγR...
Read Determination of antibody concentration as the main parameter in a dengue virus antibody-dependent enhancement assay using FcγR-expressing BHK cells, Archives of Virology on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/determination-of-antibody-concentration-as-the-main-parameter-in-a-6VUO89P8As
Antibody-dependent enhancement of viral infection is certainly a well-described phenomenon that - Discovery of Inhibitors of...Antibody-dependent enhancement of viral infection is certainly a well-described phenomenon that - Discovery of Inhibitors of...
Antibody-dependent enhancement of viral infection is certainly a well-described phenomenon that is certainly structured on the cellular uptake of infectious virus-antibody complexes following their interaction with Fc receptors expressed on myeloid cells. mediated attachment of the computer virus to the plasma membrane also at neutral pH, thereby increasing viral infectivity. Since antibody-induced enhancement of binding was not only observed with cells but also with liposomes, it is usually likely that increased contamination was due to FL-lipid interactions and not PF-3644022 to interactions with cellular plasma membrane proteins. The novel mechanism of antibody-induced contamination enhancement adds a new facet to the complexity of antibody interactions with flaviviruses and may have implications for yet unresolved effects of polyclonal antibody responses on biological properties of these viruses. Author summary Antibodies are an important component of antiviral host responses and their ...
http://biotechnologysymposium.com/antibody-dependent-enhancement-of-viral-infection-is-certainly-a-well-described-phenomenon-that/
Antibody Dependent Enhancement (ADE)Antibody Dependent Enhancement (ADE)
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https://www.epatienthealthcare.com/tag/antibody-dependent-enhancement-ade/
Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement | Virology...Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody-dependent enhancement | Virology...
DENV infection elicits primarily a poor quality immune response directing a high proportion of antibody against non-protective, potentially pathogenic epitopes and only a small proportion against potently neutralizing and protective epitopes. In this report we have shown the manipulation of these potentially pathogenic epitopes as a vaccine strategy [41] that can reduce ADE in vitro and in vivo. Immunization of mice demonstrated that knocking out immunodominant cross-reactive epitopes in the EDIIFP and EDIII did not significantly effect DENV-2 neutralization, however the removal of these epitopes dramatically altered the vaccine induced antibody repertoire and sera from vaccinated mice shows reduced ADE in vitro and reduced lethal enhancement of DENV in vivo. Such a strategy could be applicable to other DENV vaccine formats, however, it might not be applicable to DENV live-attenuated vaccines because mutations in the EDIIFP can be lethal [42].. Our findings demonstrate that by introducing ...
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-9-115
Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus - Nuffield Department of...
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https://www.ndm.ox.ac.uk/publications/733928
A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue...A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/19859541?dopt=Abstract
west nile virus Protocols and Video...west nile virus Protocols and Video...
Video articles in JoVE about west nile virus include In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection, Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses, Genome-Wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy, Detection of Infectious Virus from Field-collected Mosquitoes by Vero Cell Culture Assay, Efficient Agroinfiltration of Plants for High-level Transient Expression of Recombinant Proteins, Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency, Rescue and Characterization of Recombinant Virus from a New World Zika Virus Infectious Clone, A Simple Flow Cytometry Based Assay to Determine In Vitro Antibody Dependent Enhancement of Dengue Virus Using Zika Virus Convalescent Serum, Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds, High-throughput Screening for
https://www.jove.com/keyword/west+nile+virus
Betomania Betrug Fundamentals Explained
Immunopathogenesis of Intense Dengue in Secondary Infections.The kinetics of viremia inside of a individual with secondary dengue, the timing of typical difficulties, and achievable mechanistic results in are proven. Early in secondary an infection (or Most important infection of infants), antibody-dependent enhancement is assumed to boost in vivo concentrations of virus.17 Antibody-dependent improvement is associated with the existence of non-neutralizing or subneutralizing levels of dengue virus-reactive IgG induced by a Principal an infection, or obtained passively in newborns. A large infected cell mass leads to elevated concentrations of acute-period reaction proteins, cytokines, and chemokines; technology of immune complexes; and use of enhance and launch of break up products. The activation, proliferation, and secretion of cytokines in tissues by memory T lymphocytes recognizing conserved and altered peptide ligands are postulated to incorporate on the inflammatory milieu throughout ...
http://damienwxvtp.timeblog.net/1653569/betomania-betrug-fundamentals-explained
Moxifloxacin HCl cell signalingMoxifloxacin HCl cell signaling
Antibody-dependent enhancement (ADE) has been proposed as a mechanism to explain dengue hemorrhagic fever (DHF) in the course of a secondary dengue infection. roles in virus attachment to cells and fusion with membranes, and is the major target for neutralizing antibody. It contains the main epitopes recognized by neutralizing antibodies (virus-particular and cross-reactive epitopes) [5,6]. This proteins offers three structural and practical domains: domain II provides the inner fusion peptide (in charge of the fusion of flaviviruses with their target cellular material) and domain III the cellular receptor-binding motifs [7,8]. Domains I and III consist of predominantly subcomplex- and type-particular epitopes, whereas domain II provides the main flavivirus group and subgroup cross-reactive epitopes [9C11]. M protein could be within two forms. In cell-connected (immature) virions, prM (the precursor of M proteins) is noticed, which forms a heterodimer with the Electronic protein (prM-Electronic ...
http://www.aboutsciencenow.info/index.php/tag/moxifloxacin-hcl-cell-signaling/
Fc receptor - WikipediaFc receptor - Wikipedia
An Fc receptor is a protein found on the surface of certain cells - including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells - that contribute to the protective functions of the immune system. Its name is derived from its binding specificity for a part of an antibody known as the Fc (Fragment, crystallizable) region. Fc receptors bind to antibodies that are attached to infected cells or invading pathogens. Their activity stimulates phagocytic or cytotoxic cells to destroy microbes, or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some viruses such as flaviviruses use Fc receptors to help them infect cells, by a mechanism known as antibody-dependent enhancement of infection. There are several different types of Fc receptors (abbreviated FcR), which are classified based on the type of antibody that they recognize. The Latin letter ...
https://en.wikipedia.org/wiki/Fc_receptor
The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells | ScienceThe Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells | Science
Antibodies that enhance human immunodeficiency virus (HIV) infectivity have been found in the blood of infected individuals and in infected or immunized animals. These findings raise serious concern for the development of a safe vaccine against acquired immunodeficiency syndrome. To address the in vivo relevance and mechanism of this phenomenon, antibody-dependent enhancement of HIV infectivity in peripheral blood macrophages, lymphocytes, and human fibroblastoid cells was studied. Neither Leu3a, a monoclonal antibody directed against the CD4 receptor, nor soluble recombinant CD4 even at high concentrations prevented this enhancement. The addition of monoclonal antibody to the Fc receptor III (anti-FcRIII), but not of antibodies that react with FcRI or FcRII, inhibited HIV type 1 and HIV type 2 enhancement in peripheral blood macrophages. Although enhancement of HIV infection in CD4+ lymphocytes could not be blocked by anti-FcRIII, it was inhibited by the addition of human immunoglobulin G ...
http://science.sciencemag.org/content/244/4910/1357
Scientific Program Day 1Scientific Program Day 1
Live-attenuated vaccines (LAV) are reputed to be the most cost-effective tools for controlling epidemics. With increasing disease outbreaks caused by virus infections, vaccines will have to be delivered to both adults and children, who may have pre-existing cross-reactive antibodies due to previous exposure with an antigenically related virus strain. We and others have shown in vitro that cross-reactive antibodies can improve vaccine efficacy by enhancing LAV infection in Fc gamma-receptor (FcgR) expressing antigen-presenting cells (APCs), a process known as antibody-dependent enhancement (ADE). However, the relevance and occurrence of ADE has yet to be demonstrated clinically. We conducted an open-label trial where subjects are sequentially immunized with the inactivated Japanese Encephalitis (JE) vaccine (Ixiaro®) followed by a live-attenuated yellow fever (YF) vaccine (Stamaril®). To generate a range of cross-reactive antibodies concentrations, subjects were divided into 3 groups, where ...
https://syntheticbiology.conferenceseries.com/asiapacific/2017/scientific-program.php?day=1&sid=4006&date=2017-11-09
T Cell-Boosting Zika Vaccine Protects Mice from the VirusT Cell-Boosting Zika Vaccine Protects Mice from the Virus
Antibodies created during a viral infection or in response to a vaccine help to prevent reinfection with that specific virus but can, in some cases, worsen infections by similar ones. This phenomenon, called antibody-dependent enhancement (ADE), is particularly problematic for the related flaviviruses Zika and dengue. Researchers are therefore developing vaccination strategies to avoid the issue, and results from the latest incarnation tested in mice were reported yesterday (May 11) in Cell Reports. In the vaccine field, people have been focused on eliciting antibody responses, and thats great of course, but . . . T cells are also important in mediating protective immunity, says immunologist Sujan Shresta of the La Jolla Institute for Immunology who works on Zika and dengue vaccination strategies and has developed her own T cell-boosting vaccine but was not involved in the new study. Her progress together with yesterdays report really challenges the dogma, that antibodies are the most ...
https://www.breathinglabs.com/monitoring-feed/genetics/t-cell-boosting-zika-vaccine-protects-mice-from-the-virus/
JoVE Author Search: Isern S
Antibodies, Antibody-dependent Enhancement, Concentrations, Dengue, Dengue Virus, Disease, Epitopes, Fc Receptor, Glycoprotein, Histories, Human, Infection, Inhibition, Liposome, Monoclonal Antibodies, Mosquito, Mutations, Patients, Proteins, Therapeutic
http://labindex.jove.com/author/Isern-S
Can Covid-19 Vaccines Keep up with an Evolving Virus? - biotechTODAY
We are starting to see a few mutations of the SARS-CoV-2 virus that impact the spike surface antigen, said Alexandre Le Vert, Executive Chairman and co-founder of the French vaccine firm Osivax. If these mutation trends persist and increase with the worldwide spread of the virus, we believe that the vaccines targeting the spike surface antigen might have limited efficacy.. Furthermore, Le Vert pointed out that mutations in surface proteins on the SARS-CoV-2 virus could even cause some vaccines to exacerbate the infection. This can happen via a phenomenon known as antibody-dependent enhancement, where certain antibodies stick to the virus incorrectly and make it even better at infecting cells.. So how can we make sure that Covid-19 vaccines wont get outpaced by an evolving virus? According to the UK company Emergex, a key clue lies in studying vaccines for other viral infections that have proved effective for decades.. Last week, Emergex released the results of an investigation into immune ...
https://biotechtoday.ca/news/can-covid-19-vaccines-keep-up-with-an-evolving-virus/
OpenEmory | Search ResultsOpenEmory | Search Results
Therapies to prevent maternal Zika virus (ZIKV) infection and its subsequent fetal developmental complications are urgently required. We isolated three potent ZIKV-neutralizing monoclonal antibodies (nmAbs) from the plasmablasts of a ZIKV-infected patient-SMZAb1, SMZAb2, and SMZAb5-directed against two different domains of the virus. We engineered these nmAbs with Fc LALA mutations that abrogate Fcg receptor binding, thus eliminating potential therapy-mediated antibody-dependent enhancement. We administered a cocktail of these three nmAbs to nonhuman primates 1 day before challenge with ZIKV and demonstrated that the nmAbs completely prevented viremia in serum after challenge. Given that numerous antibodies have exceptional safety profiles in humans, the cocktail described here could be rapidly developed to protect uninfected pregnant women and their fetuses ...
https://open.library.emory.edu/publications/search/?department=Infectious+Disease&keywords=vaccin&keywords=rhesus&subject=Biology%2C+Cell&author=Chahroudi%2C+Ann&keywords=research
Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT1 and NF-kB) complexes by antibody-dependent...Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT1 and NF-kB) complexes by antibody-dependent...
TY - JOUR. T1 - Suppression of lipopolysaccharide-induced antiviral transcription factor (STAT1 and NF-kB) complexes by antibody-dependent enhancement of macrophage infection by Ross River virus. AU - Mahalingam, Surendran. AU - Lidbury, Brett. PY - 2002. Y1 - 2002. N2 - Subneutralizing concentrations of antibody may enhance virus infection by bringing the virus-antibody complex into contact with the cell surface Fc receptors; this interaction facilitates entry of virus into the cell and is referred to as antibody-dependent enhancement (ADE) of infection. Northern analysis of macrophage RNA demonstrated that ADE infection by the indigenous Australian alphavirus Ross River (RRV-ADE) ablated or diminished message for tumor necrosis factor alpha (TNF-alpha), nitric-oxide synthase 2 (NOS2), and IFN regulatory factor 1 (IRF-1), as well as for IFN-inducible protein 10 (IP-10) and IFN-beta; the transcription of a control gene was unaffected. Additionally, electrophoretic mobility-shift assay (EMSA) ...
https://researchprofiles.canberra.edu.au/en/publications/suppression-of-lipopolysaccharide-induced-antiviral-transcription
Calcium‐dependent enhancement by carbachol of the VIP‐induced cyclic AMP accumulation in cat submandibular gland<...
TY - JOUR. T1 - Calcium‐dependent enhancement by carbachol of the VIP‐induced cyclic AMP accumulation in cat submandibular gland. AU - ENYEDI, PETER. AU - FREDHOLM, BERTIL B.. PY - 1984/4. Y1 - 1984/4. N2 - The interaction of two coexisting transmitters in the cat submandibular gland has been elucidated by studying effects of VIP and carbachol on cyclic AMP accumulation in isolated acini from the gland. Carbachol was found to potentiate the cyclic AMP increase induced by VIP by an atropine sensitive mechanism. The effect of carbachol on cyclic AMP accumulation was abolished by including EGTA in the incubation medium as was the carbachol mediated potentiation of VIP responses. The calmodulin inhibitor trifluoperazine had a similar, but less marked effect. The effect of carbachol was mimicked by phenylephrine (30 μM) and by the calcium inophore A 23187 (3 μM), and also by ethanol in a concentration reported to enhance membrane fluidity. The phospholipase A2 inhibitor, mepacrine, tended to ...
https://hungary.pure.elsevier.com/en/publications/calciumdependent-enhancement-by-carbachol-of-the-vipinduced-cycli
Absence of antibody-dependent enhancement (ADE) of viral infectivity in the epidemic neuropathy in Cuba.Absence of antibody-dependent enhancement (ADE) of viral infectivity in the epidemic neuropathy in Cuba.
대전광역시 유성구 대학로 245 한국과학기술정보연구원TEL : 042.869.1234 서울시 동대문구 회기로 66NDSL고객센터 : 080.969.4114E-mail : [email protected] 대표자 : 한선화사업자등록번호 : 205-82-04043 ...
http://www.ndsl.kr/ndsl/search/detail/article/articleSearchResultDetail.do?cn=NART00103122
Community Academic Profiles - Faculty & Researchers - Stanford MedicineCommunity Academic Profiles - Faculty & Researchers - Stanford Medicine
Current Research and Scholarly Interests Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that IgG repertoire diversity is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. Our work is defining how diversity that exists in the IgG Fc domain repertoire among people, which we define by serum IgG subclass and Fc glycoform distributions, impacts immune processes such as vaccine responses and susceptibility to antibody-dependent enhancement of dengue disease (Wang TT, Cell. 2015 and Wang TT, Science. 2017). IgG subclass and Fc glycoform distributions are key regulators of immunity because these determine the structure of Fc domains within immune complexes that form during vaccination or infection. Fc structure, in turn, determines the affinity of immune complexes for various Fc receptors on effector cells. Thus, we are studying how the Fc domain repertoire of an ...
https://med.stanford.edu/profiles/medicine/browse?name=w&org=school-of-medicine/medicine/infectious-diseases
Community Academic Profiles - Faculty & Researchers - Stanford MedicineCommunity Academic Profiles - Faculty & Researchers - Stanford Medicine
Current Research and Scholarly Interests Studies in our lab are aimed at defining mechanisms in human immunity and disease. We are particularly interested the hypothesis that IgG repertoire diversity is a central driver of heterogeneity in human immune functioning and susceptibility to infectious diseases. Our work is defining how diversity that exists in the IgG Fc domain repertoire among people, which we define by serum IgG subclass and Fc glycoform distributions, impacts immune processes such as vaccine responses and susceptibility to antibody-dependent enhancement of dengue disease (Wang TT, Cell. 2015 and Wang TT, Science. 2017). IgG subclass and Fc glycoform distributions are key regulators of immunity because these determine the structure of Fc domains within immune complexes that form during vaccination or infection. Fc structure, in turn, determines the affinity of immune complexes for various Fc receptors on effector cells. Thus, we are studying how the Fc domain repertoire of an ...
https://med.stanford.edu/profiles/pathology/browse?name=w&p=1&ps=50&org=school-of-medicine/medicine
Disease | Page 6 | Global
Brazilian soldiers last year led a battle against Zika in a door-to-door campaign about how to control mosquitoes that carry the disease. EVARISTO SA/AFP/GETTY IMAGES. CLICK HERE - Science - Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity. sciencemag.org - by Jon Cohen - March 30, 2017. Close relatives have complicated relationships with each other even in the viral world. A new mouse study shows that if the animals have antibodies from dengue or West Nile virus, it sets them up for more severe disease from their close cousin, Zika virus.. If such antibody-dependent enhancement (ADE) also takes place in people, it could have helped fuel Zikas recent explosion in Brazil, where more than 90% of people in some communities have been infected with dengue. ADE could also complicate the development of vaccines for West Nile, dengue, and Zika. And with the onset of spring reigniting local transmission of Zika last week in the continental United States-where West Nile is ...
http://resiliencesystem.com/category/general-topic-tags/disease?page=5
The Jab Propaganda Falls Apart: Vaccinated People Account for 60% of COVID-19 Deaths in the UK - Global ResearchGlobal...The Jab Propaganda Falls Apart: Vaccinated People Account for 60% of COVID-19 Deaths in the UK - Global ResearchGlobal...
What transpired next is what keeps me awake at night given the number of family and friends who have been vaccinated. The lab animals that developed antibodies once they got jabbed were wiped out once their short-lived immunity wore off and they were reintroduced to SARS. What led to their wholesale extermination was a condition called Antibody-Dependent Enhancement (ADE). An autoimmune disease much like HIV/AIDS, ADE hijacks immune systems and turns an organisms natural defense systems against its own vital organs.. If we actually had a free-press, the breathtaking developments in the UK would be treated as breaking news and politicians would treat this devastating development as the crisis it truly is. To the contrary, the political class and their enablers in mainstream media are bandying talking points stating that 99% of Covid-19 deaths in America are attributed to the unvaccinated. What they are omitting from this propaganda is that they are not using the same PCR [enlargement] ...
https://www.globalresearch.ca/jab-propaganda-falls-apart-vaccinated-people-account-60-covid-19-deaths-uk/5749495
grapes disease in humansgrapes disease in humans
In contrast, Hashimotos thyroiditis develops in chickens, rats, mice, dogs, and marmosets. More than 17 million mink are being culled and dumped in mass graves in Denmark today in a desperate bid to eradicate a mutated strain of coronavirus. Attempts to induce an immune response in mice to the luteinizing-hormone receptor suggested that autoantigen glycosylation was one parameter involved in breaking self-tolerance. Importance Graves disease is the most common cause of persistent hyperthyroidism in adults. A report by the National Institute of Diabetes and Digestive and Kidney Diseases suggests that individuals with advanced chronic kidney disease and diabetes limit their intake of certain foods, including grapes . Goals / Objectives The morbidity and mortality associated with obesity is directly related to the increased risk of hypertension, cardiovascular disease, as well as the development of type II diabetes mellitus. Although suspected, such antibody-dependent enhancement of severe disease ...
https://adamgemili.com/wiki/archive.php?tag=4a565b-grapes-disease-in-humans
51Cr Release Assay of Antibody‐Dependent Cell‐Mediated Cytotoxicity (ADCC) - Current Protocols51Cr Release Assay of Antibody‐Dependent Cell‐Mediated Cytotoxicity (ADCC) - Current Protocols
Antibody‐dependent cell‐mediated cytotoxicity (ADCC) is an immunologic cytotoxic effector mechanism that is dependent on the cooperative interaction of humoral and cellular effector elements
http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im0727.html
2019-1332019-133
Dengue virus infection is one of the most common mosquito-borne illnesses worldwide, with nearly four billion people living in at risk areas throughout the world. Reported cases to World Health Organization continue to rise exponentially with an estimated 50 - 100 million symptomatic cases, mostly in Asia. Most clinical cases present with a self-limited viral illness, but some experience life-threatening severe disease. Four serotypes of dengue virus exist; infection by one serotype confers long lasting homotypic immunity, but does not confer heterotypic immunity to another serotype. Subsequent infection from a different dengue serotype can lead to the development of severe dengue. Antibody-dependent enhancement of dengue virus infection has been implicated in the development of severe disease. There have been various efforts to develop vaccines against dengue, including subunit vaccines that use only the viral envelope glycoprotein, or portions thereof. Those efforts are hampered by the ...
http://philsciletters.net/2019-133/
Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. | Journal of...Activation of endothelial cells via antibody-enhanced dengue virus infection of peripheral blood monocytes. | Journal of...
Although endothelial cells have been speculated to be a target in the pathogenesis of dengue hemorrhagic fever (DHF), there has been little evidence linking dengue virus infection to any alteration in endothelial cell function. In this study, we show that human umbilical vein endothelial cells become activated when exposed to culture fluids from dengue virus-infected peripheral blood monocytes. Maximum activation was achieved with culture fluids from monocytes in which virus infection was enhanced by the addition of dengue virus-immune serum, thus correlating with epidemiological evidence that prior immunity to dengue virus is a major risk factor for DHF. Activation was strongest for endothelial cell expression of VCAM-1 and ICAM-1. In contrast, activation of endothelial cell E-selectin expression appeared to be more transient, as indicated by its detection at 3 h, but not at 16 h, of treatment. Treatment of monocyte culture fluids with anti-tumor necrosis factor alpha (TNF-alpha) antibody ...
https://jvi.asm.org/content/71/6/4226
Dengue Hemorrhagic Fever Model may Need a RethinkDengue Hemorrhagic Fever Model may Need a Rethink
The dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF) is being challenged by research published this week in PLoS Medicine.
http://www.medindia.net/news/Dengue-Hemorrhagic-Fever-Model-may-Need-a-Rethink-60067-1.htm
Modulation of GABAergic Signaling in Retinal Amacrine Cells - OpenThesis
The intricate circuitry formed by amacrine cells in the inner plexiform layer (IPL) of the retina suggests that these interneurons play a major role in shaping the visual message. The majority of amacrine cells in the vertebrate retina are GABAergic. Thus, elucidating how GABAergic signaling is modulated in the IPL is critical in order to understand how the visual message is processed in the retina. The results presented here suggest that GABAergic signaling between amacrine cells can be modulated by the activation of metabotropic glutamate receptor 5 (mGluR5) or by the production of the second messenger, nitric oxide (NO). A novel mGluR5 splice variant was isolated from the chicken retina with a truncated carboxy-terminal tail. Whole cell electrophysiological experiments indicated that activation of mGluR5 enhances GABA-gated currents recorded from cultured chick amacrine cells. This mGluR5-dependent enhancement occurred through the inositol 1,4,5-trisphosphate pathway and was dependent upon ...
http://www.openthesis.org/documents/Modulation-GABAergic-Signaling-in-Retinal-525876.html
AddexBio Product Detail - K562 CellsAddexBio Product Detail - K562 Cells
1. Chen, Z., Luo, H. Y., Steinberg, M. H., and Chui, D. H. BCL11A represses HBG transcription in K562 cells. Blood Cells Mol Dis, 42: 144-149, 2009. 2. Konishi, E., Tabuchi, Y., and Yamanaka, A. A simple assay system for infection-enhancing and -neutralizing antibodies to dengue type 2 virus using layers of semi-adherent K562 cells. J Virol Methods, 163: 360-367. 3. Navarro, F., Gutman, D., Meire, E., Caceres, M., Rigoutsos, I., Bentwich, Z., and Lieberman, J. miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53. Blood, 114: 2181-2192, 2009. 4. Reuter, S., Charlet, J., Juncker, T., Teiten, M. H., Dicato, M., and Diederich, M. Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Ann N Y Acad Sci, 1171: 436-447, 2009. 5. Salvatori, F., Cantale, V., Breveglieri, G., Zuccato, C., Finotti, A., Bianchi, N., Borgatti, M., Feriotto, G., Destro, F., Canella, A., Breda, L., Rivella, S., and Gambari, R. ...
https://addexbio.com/productdetail?pid=52
Biology-OnlineBiology-Online
Research recently published in PLoS Medicine challenges the dogma of the antibody-dependent enhancement model (ADE) for the development of dengue hemorrhagic fever (DHF). Dengue virus infection usually causes a severe flu like illness, although symptoms may be mild in young children. DHF, however, is a severe and sometimes fatal complication of dengue virus infection that affects about half a million people every year. DHF patients usually fall into two groups; children and adults who become infected with a second dengue virus serotype after an initial primary dengue virus infection with a different serotype, and infants with primary dengue virus infections born to mothers who have some dengue virus immunity. The current model for development of DHF in infants around 6 months old is that anti-dengue virus antibodies transferred from a dengue-immune mother to her child somehow enhance dengue virus infection, resulting in more severe symptoms (the antibody-dependent enhancement model). A ...
https://www.biology-online.org/articles/rethinking-antibody-dependent-enhancement-dengue-hemorrhagic.html
High pro-inflammatory cytokine secretion and loss of high avidity cross-reactive cytotoxic T-cells during the course of...
BACKGROUND: Dengue is one of the most important human diseases transmitted by an arthropod vector and the incidence of dengue virus infection has been increasing - over half the worlds population now live in areas at risk of infection. Most infections are asymptomatic, but a subset of patients experience a potentially fatal shock syndrome characterised by plasma leakage. Severe forms of dengue are epidemiologically associated with repeated infection by more than one of the four dengue virus serotypes. Generally attributed to the phenomenon of antibody-dependent enhancement, recent observations indicate that T-cells may also influence disease phenotype. METHODS AND FINDINGS: Virus-specific cytotoxic T lymphocytes (CTL) showing high level cross reactivity between dengue serotypes could be expanded from blood samples taken during the acute phase of secondary dengue infection. These could not be detected in convalescence when only CTL populations demonstrating significant serotype specificity were
https://www.imm.ox.ac.uk/publications/34066/
Tropical feverTropical fever
Dengue virus is a human pathogen that causes dengue fever, which can either resolve after mild fever or lead to severe dengue hemorrhagic fever/dengue shock syndrome. The role of dengue virus levels in the blood and the kinetics of infection and immune response that results in severe dengue disease in humans is not well characterized. In this study, we analyzed 97 children with varying degrees of dengue disease, and we show that the dengue virus quantity in blood does not show any significant association with severe disease. However, most severe dengue patients had lower levels of interferons and Th1 cytokines and increased levels of secreted factors such as IL-6, IL-8 and IL-10 that could potentially cause leakage in blood capillaries. Our results indicate that monocytes, which are infected with dengue virus in patients, could possibly play a major role in dengue pathogenesis. Furthermore, using computational analysis we identified association of some of the secreted factors with severe disease ...
http://www.fast-trackdiagnostics.com/human-line/resources/publications/tropical-fever/
Dengue disease (DENV) an infection of human beings is presently the main arthropod-borne viral global risk, for which zero...Dengue disease (DENV) an infection of human beings is presently the main arthropod-borne viral global risk, for which zero...
Dengue disease (DENV) an infection of human beings is presently the main arthropod-borne viral global risk, for which zero suitable or reliable pet model exists. Reviews addressing the result of DENV on vascular elements apart from endothelial cells lack. Dengue virus an infection of vascular even muscle cells, which play a physiological compensatory response to hypotension in arterioles and arteries, is not characterized, hence precluding our knowledge of the function of these vascular parts in dengue pathogenesis. Consequently, we analyzed the permissiveness of main human being umbilical artery clean muscle mass cells (HUASMC) to DENV 1C4 illness and compared with the infection in the previously reported main human being umbilical vein endothelial cells (HUVEC) and the classically used, non-transformed, and highly permissive Lilly Laboratories Cell-Monkey Kidney 2 cells. Our outcomes present that HUASMC are successful and vunerable to an infection using the four DENV serotypes, although to a ...
http://www.cancerrealitycheck.com/2020/09/24/%EF%BB%BFdengue-disease-denv-an-infection-of-human-beings-is-presently-the-main-arthropod-borne-viral-global-risk-for-which-zero-suitable-or-reliable-pet-model-exists/
Analysis of a Dengue Disease Model with Nonlinear IncidenceAnalysis of a Dengue Disease Model with Nonlinear Incidence
A dengue disease epidemic model with nonlinear incidence is formulated and analyzed. The equilibria and threshold of the model are found. The stability of the system is analyzed through a geometric approach to stability. The proposed model also exhibits backward bifurcation under suitable conditions on parameters. Our results imply that a nonlinear incidence produces rich dynamics and they should be studied carefully in order to analyze the spread of disease more accurately. Finally, numerical simulations are presented to illustrate the analytical findings.
https://www.hindawi.com/journals/ddns/2013/320581/
Davidson, A. D.<...Davidson, A. D.<...
The dengue viruses are spread by mosquitoes and infect up to 390 million individuals annually in sub-tropical and tropical regions of the world. Dengue disease has emerged as the most important arthropod-borne viral disease of humans. Dengue virus infection generally results in dengue fever, a debilitating but self limited febrile disease. However, complications may arise, leading to the potentially fatal dengue haemorrhagic fever/dengue shock syndromes (DHF/DSS). Despite intensive research over recent years, the pathogenesis of DHF/DSS is still poorly understood and there is neither a safe and effective vaccine nor suitable anti-viral treatments to control dengue disease.. Current investigations in the laboratory focus on understanding the role of specific viral proteins in the virus lifecycle and the role they play in perturbing host cellular processes. Our studies use a dengue virus reverse genetic system, in combination with structural, biochemical and high throughput transcriptomic and ...
https://research-information.bris.ac.uk/en/persons/andrew-d-davidson
Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays<...
TY - JOUR. T1 - Prolonged persistence of IgM against dengue virus detected by commonly used commercial assays. AU - Chien, Yu-Wen. AU - Liu, Zi Hu. AU - Tseng, Fan Chen. AU - Ho, Tzu Chuan. AU - Guo, How-Ran. AU - Ko, Nai-Ying. AU - Ko, Wen-Chien. AU - Perng, Guey-Chuen. PY - 2018/4/2. Y1 - 2018/4/2. N2 - Background: Initial symptoms of dengue fever are non-specific, and thus definite diagnosis requires laboratory confirmation. Detection of IgM against dengue virus (DENV) has become widely used for dengue diagnosis. Understanding the persistence of anti-DENV IgM in subjects after acute infection is essential in order to interpret test results correctly. Although the longevity of anti-DENV IgM has been vehemently investigated in symptomatic children, anti-DENV IgM persistence in adults and in asymptomatically infected people have seldom been reported. Methods: We prospectively investigated 44 adults with detectable anti-DENV IgM in a serosurvey conducted in the 2015 dengue epidemic in Tainan, ...
https://researchoutput.ncku.edu.tw/en/publications/prolonged-persistence-of-igm-against-dengue-virus-detected-by-com
What is the immunopathology of severe dengue (dengue hemorrhagic fever)?What is the immunopathology of severe dengue (dengue hemorrhagic fever)?
The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more
https://www.medscape.com/answers/215840-43473/154931-overview
What is the immunopathology of severe dengue (dengue hemorrhagic fever)?What is the immunopathology of severe dengue (dengue hemorrhagic fever)?
The immunopathology of severe dengue remains incompletely understood. Most patients who develop severe dengue have had prior infection with one or more dengue serotypes. When an individual is infected... more
https://www.medscape.com/answers/215840-43473/182986-overview
Frontiers | Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection | ImmunologyFrontiers | Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection | Immunology
Dengue virus (DENV) has spread through most tropical and subtropical areas of the world and represents a serious public health problem. The control of DENV infection has not yet been fully successful due to lack of effective therapeutics or vaccines. Nevertheless, a better understanding of the immune responses against DENV infection may reveal new strategies for eliciting and improving antiviral immunity. T cells provide protective immunity against various viral infections by generating effector cells that cooperate to eliminate antigens and memory cells that can survive for long periods with enhanced abilities to control recurring pathogens. Following activation, CD8 T cells can migrate to sites of infection and kill infected cells, whereas CD4 T cells contribute to the elimination of pathogens by trafficking to infected tissues and providing help to innate immune responses, B cells, as well as CD8 T cells. However, it is now evident that CD4 T cells can also perform cytotoxic functions and induce
https://www.frontiersin.org/articles/10.3389/fimmu.2016.00531/full
Dengue diseaseDengue disease
Build: Wed Jun 21 18:33:50 EDT 2017 (commit: 4a3b2dc). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...
https://pharos.nih.gov/idg/diseases/Dengue%20disease
Dengue virus infection may increase risk for developing leukemiaDengue virus infection may increase risk for developing leukemia
(HealthDay)-Dengue virus infection is associated with an increased risk for leukemia, according to a study published online Feb. 12 in Cancer Epidemiology, Biomarkers & Prevention.
https://medicalxpress.com/news/2020-02-dengue-virus-infection-leukemia.html
goldburn male enhancement fizzPOPgoldburn male enhancement fizzPOP
Most intense and passionate Love-making Male Enhancement Pills Enhancement Pills & Supplements | goldburn male enhancement For Men | fizzPOP
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Antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies against cell surface molecules other...Antibody-dependent enhancement of dengue virus infection mediated by bispecific antibodies against cell surface molecules other...
It is known that antibodies to dengue viruses at subneutralizing concentrations enhance dengue virus infection of Fc gamma R+ cells. This phenomenon called antibody-dependent enhancement (ADE) occurs when virus-antibody complexes bind to the Fc gamma R via the Fc portion of the Ig. It has been hypothesized that ADE may be responsible for the pathogenesis of the severe manifestations of dengue virus infection including dengue hemorrhagic fever/dengue shock syndrome. To further analyze the mechanisms of ADE, we prepared bispecific antibodies by chemically cross-linking antidengue virus antibodies to antibodies specific for Fc gamma RI or Fc gamma RII and the non-Fc R molecules beta2 microglobulin, CD15 or CD33 and examined whether these bispecific antibodies could enhance infection. Bispecific antibodies targeting dengue virus to Fc gamma RI or Fc gamma RII enhanced dengue virus infection, consistent with previous reports using conventional antibodies. Furthermore, bispecific antibodies targeting ...
https://www.jimmunol.org/content/147/9/3139
PLOS Neglected Tropical Diseases: Epidemiology of Dengue Disease in the Philippines (2000-2011): A Systematic Literature ReviewPLOS Neglected Tropical Diseases: Epidemiology of Dengue Disease in the Philippines (2000-2011): A Systematic Literature Review
Author Summary Dengue disease is a tropical and subtropical mosquito-borne viral illness and is a major health concern in the Philippines. To determine the dengue disease burden in the Philippines and identify gaps and future research needs, we conducted a literature analysis and review to describe the epidemiology of dengue disease. We used well-defined methods to search and identify relevant research conducted between 2000 and 2011. This long-term review highlights an increase in the reported incidence of dengue disease in the Philippines. The rising incidence of dengue disease may be related to a growing population, increasing urbanization, improvements in surveillance, and the limited success of vector control measures. Gaps in the epidemiological information available in the Philippines during the period 2000-2011 include comprehensive national and regional data that describe the proportion of severe dengue disease, including hospitalizations and mortality, and incidence data per 100,000 population
https://journals.plos.org/plosntds/article/comments?id=10.1371/journal.pntd.0003027
Available Technologies | CZ Biohub
AFUCOSYLATED MATERNAL ANTI-DENGUE IGGS ARE A BIOMARKER FOR SUSCEPTIBILITY TO SEVERE DENGUE DISEASE IN INFANTS. Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have developed a method for determining infant susceptibility to severe dengue disease through measurement of maternal anti-dengue IgG. Mortality rates in severe dengue disease can exceed 20% when patients are not hospitalized but can be reduced to less than 1% with inpatient care. Therefore, the identification of biomarkers for increased susceptibility to dengue disease could dramatically reduce mortality rates by enabling early hospitalization of those at highest risk for disease progression. Here, the inventors conducted a global analysis of anti-dengue IgGs from mothers of infants with known disease severity during primary dengue infections in order to identify features of maternal IgGs that indicate dengue disease risk in infants.. Stage of Research The glycosylation state of the IgG Fc domain plays a role in ...
http://czbiohub.technologypublisher.com/technology/42275
Viability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensityViability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensity
The cell viability and DNA damage in unstimulated sheep primary lymphocytes subjected to different extremely low electromagnetic field intensities (5, 50 and 100 µT; 50 Hz) were studied with special emphasis on apoptosis. Sheep primary lymphocytes cultured in RPMI, supplemented with 10% FBS in the absence of mitogens, were exposed till 16 h. The cell viability assessment by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay showed a dose dependent enhancement of viability at 16 h. Further, quantitative DNA laddering and flow cytometric analysis showed a significant decrease in apoptosis of the cells subjected to 100 (p
https://biodiscovery.pensoft.net/article/8925
Sonodynamic therapy--a review of the synergistic effects of drugs and ultrasound. - Semantic ScholarSonodynamic therapy--a review of the synergistic effects of drugs and ultrasound. - Semantic Scholar
Sonodynamic therapy, the ultrasound dependent enhancement of cytotoxic activities of certain compounds (sonosensitizers) in studies with cells in vitro and in tumor bearing animals, is reviewed. The attractive features of this modality for cancer treatment emerges from the ability to focus the ultrasound energy on malignancy sites buried deep in tissues and to locally activate a preloaded sonosensitizer. Possible mechanisms of sonodynamic therapy include generation of sonosensitizer derived radicals which initiate chain peroxidation of membrane lipids via peroxyl and/or alkoxyl radicals, the physical destabilization of the cell membrane by the sonosensitizer thereby rendering the cell more susceptible to shear forces or ultrasound enhanced drug transport across the cell membrane (sonoporation). Evidence against the role of singlet oxygen in sonodynamic therapy is discussed. The mechanism of sonodynamic therapy is probably not governed by a universal mechanism, but may be influenced by multiple factors
https://www.semanticscholar.org/paper/Sonodynamic-therapy-a-review-of-the-synergistic-ef-Rosenthal-Sostaric/16b726b37eb9d83cd67e376ecdb25c183cf125ab
Prediction of dengue disease severity among pediatric Thai patients us by James A. Potts, Robert V. Gibbons et al.Prediction of dengue disease severity among pediatric Thai patients us by James A. Potts, Robert V. Gibbons et al.
BACKGROUND: Dengue virus is endemic in tropical and sub-tropical resource-poor countries. Dengue illness can range from a nonspecific febrile illness to a severe disease, Dengue Shock Syndrome (DSS), in which patients develop circulatory failure. Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries. METHODS AND FINDINGS: We compared clinical laboratory findings collected within 72 hours of fever onset from a prospective cohort children presenting to one of two hospitals (one urban and one rural) in Thailand. Classification and regression tree analysis was used to develop diagnostic algorithms using different categories of dengue disease severity to distinguish between patients at elevated risk of developing a severe dengue illness and those at low risk. A diagnostic algorithm using WBC count, percent monocytes, platelet count, and hematocrit achieved 97% sensitivity to identify patients who went on to develop DSS while
https://escholarship.umassmed.edu/prevbeh_pp/171/
Background Dengue pathogen (DENV) contamination may trigger serious hemorrhagic disease in - Role of cytochrome P450 in drug...
Background Dengue pathogen (DENV) contamination may trigger serious hemorrhagic disease in human beings. when KU812 cells had been transfected with the autophagy-inhibiting Atg4BC74A mutant. Findings/Significance Our outcomes demonstrate a significant induction of autophagy in antibody-enhanced DENV contamination of pre-basophil-like KU812 and immature mast cell-like HMC-1 cells. Also, autophagy takes on an essential part in DENV contamination and duplication in these cells. Provided the importance of ADE and FcR-bearing cells such as monocytes, basophil/mast and macrophages cells in dengue disease, the outcomes offer information into dengue pathogenesis and restorative means of control. Intro Dengue disease is usually a serious wellness issue in exotic or subtropical areas of the globe [1], [2]. Dengue computer virus (DENV) contamination can trigger 1255517-77-1 supplier moderate dengue fever to serious life-threatening dengue hemorrhagic fever and dengue surprise symptoms [3]C[5]. Many systems ...
http://www.baxkyardgardener.com/2017/12/03/background-dengue-pathogen-denv-contamination-may-trigger-serious-hemorrhagic-disease-in/
Optimization of the Cutoff Value for a Commercial Anti-Dengue Virus IgG Immunoassay | Clinical and Vaccine ImmunologyOptimization of the Cutoff Value for a Commercial Anti-Dengue Virus IgG Immunoassay | Clinical and Vaccine Immunology
The presence of anti-DENV IgG antibodies is an indication of long-term, acquired immunity from a past DENV infection. Moreover, IgG antibody titer differences can identify an acute dengue infection when paired serum samples, consisting of acute (0 to 5 days after onset of illness) and convalescent (,5 days after onset of illness) samples, are available. However, an anti-DENV IgG result in a single sample cannot clinically diagnose an acute infection. The Focus anti-DENV IgG ELISA (catalog no. EL1500G) used in this study is an indirect ELISA, which immobilizes DENV antigens on a solid surface. The DENV antigen is then recognized by anti-DENV IgG antibodies in the tested sample. A detector antibody that is conjugated to horseradish peroxidase binds nonspecifically to human IgG and amplifies the signal for detection. The indirect anti-DENV IgG ELISA is often used for epidemiologic studies to determine past DENV exposure because of its improved sensitivity and specificity compared to the direct ...
https://cvi.asm.org/content/20/3/358
Laboratory Diagnosis and Prognosis of Severe Dengue - Full Text View - ClinicalTrials.govLaboratory Diagnosis and Prognosis of Severe Dengue - Full Text View - ClinicalTrials.gov
In a prospective study in the outpatients department of three large hospitals in Ho Chi Minh City, Viet Nam, we will determine the early diagnostic sensitivity, specificity, positive and negative predictive values of two NS1 diagnostic tests in severe dengue cases.. The study is intended to develop a prognostic algorithm for the early identification of severe dengue cases.. Routine demographic, haematological and biochemical laboratory markers will be utilized to derive a prognostic algorithm that is clinically-useful for guiding patient triage and interventions.. We hope to discover and evaluate new early biomarkers of severe dengue and will evaluate candidate host response molecules and virological markers for their prognostic value.. We further plan to understand the phylogeography of DENV in the super-urban setting of HCMC.. We will use genome scale sequencing of DENV together with geospatial information on the residential addresses of patients to better understand transmission dynamics in ...
https://clinicaltrials.gov/ct2/show/NCT01421732?recr=Open&cond=%22Hemorrhagic+Fevers%2C+Viral%22&rank=6
The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue<...
TY - JOUR. T1 - The exploration of risk factors of concurrent bacteraemia in patients critically ill with severe dengue. AU - Chen, Chin Ming. AU - Chan, Khee Siang. AU - Cheng, Kuo Chen. AU - Chou, Willy. AU - Chao, Hui Chun. AU - Yeh, Chiu Yin. AU - Yu, Wen Liang. PY - 2016/12/1. Y1 - 2016/12/1. N2 - We investigated the clinical features of intensive care unit (ICU) patients with concomitant severe dengue infection and bacteraemia to identify risk factors for this comorbidity. The records of all ICU dengue patients admitted during the period of 31 July-30 November 2015 were reviewed. Patients with concurrent bacteremia (positive bacterial blood culture within 72 h of ICU admission) were identified. ICU admission was required for 142 patients, of which 22 (15.5%) had concurrent bacteraemia. Species of the genus Streptococcus was the most common pathogens, followed by Escherichia coli then species of the genus Staphylococcus. Patients with a severe dengue infection and bacteraemia had higher ...
https://tmu.pure.elsevier.com/en/publications/the-exploration-of-risk-factors-of-concurrent-bacteraemia-in-pati
Spectrum and kinetic of T cell responses to dengue virus epitopes and the influence of hla polymorphisms in dengue disease...
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https://www.tdi.ox.ac.uk/publications/40157
Spectrum and kinetic of T cell responses to dengue virus epitopes and the influence of hla polymorphisms in dengue disease...
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https://www.immunology.ox.ac.uk/publications/40157
Antibodies Contribute to Dengue Virus InfectionAntibodies Contribute to Dengue Virus Infection
La Jolla Institute scientists have proved a hypothesis that said antibodies contribute to severe dengue virus-induced disease.
http://www.medindia.net/news/Antibodies-Contribute-to-Dengue-Virus-Infection-64952-1.htm
typing | Journal of Clinical Microbiologytyping | Journal of Clinical Microbiology
Dengue fever, caused by infections with the dengue virus (DENV), affects nearly 400 million people globally every year. Early diagnosis and management can reduce the morbidity and mortality rates of severe forms of dengue disease as well as decrease the risk of wider outbreaks. ...
https://jcm.asm.org/keyword/typing
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Antibody-dependent enhancementAntibody-dependent enhancement
... (ADE), sometimes less precisely called immune enhancement or disease enhancement, is a ... Gras GS, Dormont D (January 1991). "Antibody-dependent and antibody-independent complement-mediated enhancement of human ... They also suggested that the presence of neutralizing antibody or antibody-dependent cellular cytotoxicity-mediating antibodies ... "Modulation of Dengue/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against Enhancement ...
https://en.wikipedia.org/wiki/Antibody-dependent_enhancement
Cancer immunotherapyCancer immunotherapy
... enhancement of antibody-dependent cell-mediated cytotoxicity; and CR3-dependent cellular cytotoxicity. Complement-dependent ... Antibody-dependent cell-mediated cytotoxicity (ADCC) requires antibodies to bind to target cell surfaces. Antibodies are formed ... Naked monoclonal antibodies are antibodies without added elements. Most antibody therapies use this antibody type. Conjugated ... Chimeric antibodies attempt to reduce murine antibodies' immunogenicity by replacing part of the antibody with the ...
https://en.wikipedia.org/wiki/Cancer_immunotherapy
Neutralizing antibodyNeutralizing antibody
This mechanism is known as antibody-dependent enhancement. It has been observed for Dengue virus and Zika virus. Antibodies are ... Tirado, SM; Yoon, KJ (2003). "Antibody-dependent enhancement of virus infection and disease". Viral Immunology. 16 (1): 69-86. ... Not all antibodies that bind a pathogenic particle are neutralizing. Non-neutralizing antibodies, or binding antibodies, bind ... "Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus". Nature Immunology. 17 ( ...
https://en.wikipedia.org/wiki/Neutralizing_antibody
Ram SamudralaRam Samudrala
Viral entry inhibitors block dengue antibody-dependent enhancement in vitro. Antiviral Research 89: 71-74, 2011. Jenwitheesuk E ... McDermott J, Guerquin M, Frazier Z, Chang AN, Samudrala R. BIOVERSE: Enhancements to the framework for structural, functional, ... Samudrala R, Moult J. An all-atom distance-dependent conditional probability discriminatory function for protein structure ...
https://en.wikipedia.org/wiki/Ram_Samudrala
Dengue vaccineDengue vaccine
A plausible hypothesis is the phenomenon of antibody-dependent enhancement (ADE). American virologist Scott Halstead was one of ... "Sanofi restricts dengue vaccine but downplays antibody enhancement". CIDRAP. 1 December 2017. Retrieved 20 September 2020. " ... "Sanofi restricts dengue vaccine but downplays antibody enhancement". CIDRAP. Retrieved 2 December 2017. "Vaccines and ... Phillip Russell proposed that the vaccine only be used after antibody testing, to rule out prior dengue exposure and avoid ...
https://en.wikipedia.org/wiki/Dengue_vaccine
COVID-19 vaccine misinformation and hesitancyCOVID-19 vaccine misinformation and hesitancy
Antibody-dependent enhancement (ADE) is the phenomenon in which a person with antibodies against one virus (i.e. from infection ... 27 November 2020). "No evidence that COVID-19 vaccines cause more severe disease; antibody-dependent enhancement has not been ... August 2020). "A perspective on potential antibody-dependent enhancement of SARS-CoV-2". Nature. 584 (7821): 353-363. doi: ... vaccines had created and strengthened COVID-19 variants through a previously debunked theory of Antibody-dependent Enhancement ...
https://en.wikipedia.org/wiki/COVID-19_vaccine_misinformation_and_hesitancy
Dengue feverDengue fever
One of the concerns is that a vaccine could increase the risk of severe disease through antibody-dependent enhancement (ADE). ... The most widely accepted hypothesis is that of antibody-dependent enhancement (ADE). The exact mechanism behind ADE is unclear ... Various antibodies are generated; some bind closely to the viral proteins and target them for phagocytosis (ingestion by ... A number of tests are available to confirm the diagnosis including detecting antibodies to the virus or its RNA. A vaccine for ...
https://en.wikipedia.org/wiki/Dengue_fever
ParadoxParadox
One example is antibody-dependent enhancement (immune enhancement) of a disease's virulence; another is the hook effect ( ... However, neither of these problems is common, and overall, antibodies are crucial to health, as most of the time they do their ... The actions of antibodies on antigens can rarely take paradoxical turns in certain ways. ...
https://en.wikipedia.org/wiki/Paradox
Viral hemorrhagic feverViral hemorrhagic fever
Dengue fever becomes more virulent during a second infection by means of antibody-dependent enhancement. After the first ... The serum urea and creatine may be raised but this is dependent on the hydration status of the patient. The bleeding time tends ... By attaching to these antibodies, dengue viruses from a second infection are better able to infect the macrophages, thus ... infection, macrophages display antibodies on their cell membranes specific to the dengue virus. ...
https://en.wikipedia.org/wiki/Viral_hemorrhagic_fever
Scott HalsteadScott Halstead
He was one of the first researchers to identify the phenomenon known as antibody-dependent enhancement (ADE), where the ... Halstead, Scott B. (December 2002). "Dengue hemorrhagic fever: two infections and antibody dependent enhancement, a brief ... a phenomenon now known as antibody-dependent enhancement (ADE). This discovery influenced the future development of the dengue ... "Sanofi restricts dengue vaccine but downplays antibody enhancement". CIDRAP. 2017-12-01. Retrieved 2020-09-20. Villamor, Felipe ...
https://en.wikipedia.org/wiki/Scott_Halstead
Sunetra GuptaSunetra Gupta
Ferguson, N.; Anderson, R.; Gupta, S. (1999). "The effect of antibody-dependent enhancement on the transmission dynamics and ...
https://en.wikipedia.org/wiki/Sunetra_Gupta
Original antigenic sinOriginal antigenic sin
Antibody-dependent enhancement Cell mediated immunity Genomic imprinting Humoral immunity Polyclonal response Local optimum ... In addition, these antibodies inhibit activation of naive B cells that could make more effective antibodies to the second virus ... Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to repertoire freeze, a form ... According to Francis as cited by Richard Krause: "The antibody of childhood is largely a response to dominant antigen of the ...
https://en.wikipedia.org/wiki/Original_antigenic_sin
Immunological memoryImmunological memory
... antibody-dependent enhancement). As of 2019, researchers are still trying to find out why some vaccines produce life-long ... In addition to the formed antibodies in the body there remains a small number of memory T and B cells that make up the cellular ... Memory B cells are plasma cells that are able to produce antibodies for a long time. Unlike the naive B cells involved in the ... However, there remain antibodies previously created in the body that represent the humoral component of immunological memory ...
https://en.wikipedia.org/wiki/Immunological_memory
Reporter virus particlesReporter virus particles
A related assay tests for antibody-dependent enhancement (ADE), a phenomenon where non-neutralizing antibodies against viruses ... "A simple flow cytometry based assay to determine in vitro antibody dependent enhancement of dengue virus using Zika virus ... RVPs are most commonly used in neutralization assays, which measure the ability of serum or antibodies to prevent virus ... "Dengue Reporter Virus Particles for measuring neutralizing antibodies against each of the four dengue serotypes". PLoS ONE. 6( ...
https://en.wikipedia.org/wiki/Reporter_virus_particles
Dengue virusDengue virus
Among the possible causes are cross-serotypic immune response, through a mechanism known as antibody-dependent enhancement, ... possibly lead to severe dengue hemorrhagic shock when infected with another serotype due to antibody-dependent enhancement. ... Unfortunately, D7 proteins provoke immune responses, which raise anti-D7 antibody levels. These antibodies inhibit the function ... The human antibodies Ede1-C10, Ede2-A11, and Ede2-B7 potently neutralize all four DENV serotypes. Their Fab or scFv fragments ...
https://en.wikipedia.org/wiki/Dengue_virus
Zika virus vaccineZika virus vaccine
... the vaccine needs to minimize the possibility of antibody-dependent enhancement of dengue virus infection. As of March 31, 2017 ... The goal of a Zika virus vaccine is to produce specific antibodies against the Zika virus to prevent infection and severe ...
https://en.wikipedia.org/wiki/Zika_virus_vaccine
Multisystem inflammatory syndrome in childrenMultisystem inflammatory syndrome in children
... antibody-dependent enhancement, whereby development of antibodies could facilitate viral entry into host cells, has been ... By the time of presention, children have often developed antibodies to SARS-CoV-2, but test negative for the virus at RT-PCR. ... It also requires that there should either be a positive antigen/antibody SARS-CoV-2 test or COVID-19 exposure in the 4 weeks ... antigen or antibody tests are not always positive. Exclusion of alternative causes, including bacterial and other infections, ...
https://en.wikipedia.org/wiki/Multisystem_inflammatory_syndrome_in_children
Dengue fever outbreaksDengue fever outbreaks
One model to explain this process is known as antibody-dependent enhancement (ADE), which allows for increased uptake and ... Relation of disease severity to antibody response and virus recovered". The Yale Journal of Biology and Medicine. 42 (5): 311- ...
https://en.wikipedia.org/wiki/Dengue_fever_outbreaks
Dengvaxia controversyDengvaxia controversy
... previously uninfected people at a somewhat higher risk of a severe case of dengue fever through antibody-dependent enhancement ... Soucheray, Stephanie (December 1, 2017). "Sanofi restricts dengue vaccine but downplays antibody enhancement". Center for ...
https://en.wikipedia.org/wiki/Dengvaxia_controversy
AdeAde
... a laboratory of the DRDO in India Adverse Drug Event Antibody-dependent enhancement ADE (chemotherapy), a chemotherapy regimen ...
https://en.wikipedia.org/wiki/Ade
EnhancementEnhancement
... official downloadable content published via the World Wide Web for a video game Antibody-dependent enhancement, an increase in ... Enhancement may refer to: Breast enhancement, breast enlargement or contouring Cleavage enhancement, an increase in the ... Genetic enhancement, the use of genetic engineering to modify a person's nonpathological human traits Human enhancement, ... Image enhancement, improvement to perceived image quality Shadow and highlight enhancement, an image processing technique to ...
https://en.wikipedia.org/wiki/Enhancement
Influenza A virus subtype H7N9Influenza A virus subtype H7N9
This immune phenomenon is called antibody-dependent enhancement (ADE), and is perhaps best known in cases of Dengue fever when ... It is thought to occur when weakly cross-reactive antibodies form bridging complexes to facilitate uptake and replication of ... The phenomenon of cross-reacting antibodies that facilitate infection is best known in dengue infections, according to ... "Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China". BMC Infectious Diseases. 16 (1): 632. doi: ...
https://en.wikipedia.org/wiki/Influenza_A_virus_subtype_H7N9
List of acronyms: AList of acronyms: A
Algebraic differential equation Antibody-dependent enhancement ADF (i) Australian Defence Force African Development Foundation ... Administration for Native Americans Afghan National Army All Nippon Airways Anti-Nuclear Anti-body (a) Australian National ... American Physical Society Antiphospholipid Antibody Syndrome AQ (i) AdventureQuest (s) American Samoa (FIPS 10-4 territory code ...
https://en.wikipedia.org/wiki/List_of_acronyms:_A
List of MeSH codes (G04)List of MeSH codes (G04)
... antibody-dependent enhancement MeSH G04.185.515.880.210 - cell transformation, viral MeSH G04.185.515.880.225 - cytopathogenic ... antibody-dependent cell cytotoxicity MeSH G04.610.270.500 - macrophage activation MeSH G04.610.484.100 - clonal anergy MeSH ... antibody affinity MeSH G04.610.143.140 - antigenic modulation MeSH G04.610.143.232 - binding sites, antibody MeSH G04.610. ... antibody diversity MeSH G04.610.626.073 - antigenic variation MeSH G04.610.626.320 - gene rearrangement, b-lymphocyte MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(G04)
Adverse eventAdverse event
... adverse event Adverse effect Adverse drug reaction Adverse vaccine event Adverse outcome pathway Antibody-dependent enhancement ...
https://en.wikipedia.org/wiki/Adverse_event
History of COVID-19 vaccine developmentHistory of COVID-19 vaccine development
... a vaccine may have an unintended opposite effect by causing antibody-dependent disease enhancement (ADE), which increases the ... The antibody response to a vaccine is a variable of vaccine technologies in development, including whether the vaccine has ... Although the quality and quantity of antibody production by a potential vaccine is intended to neutralize the COVID‑19 ... June 2020). "Consensus summary report for CEPI/BC March 12-13, 2020 meeting: Assessment of risk of disease enhancement with ...
https://en.wikipedia.org/wiki/History_of_COVID-19_vaccine_development
Index of immunology articlesIndex of immunology articles
... antibodies Antibody Antibody opsonization Antibody-dependent cell-mediated cytotoxicity Antibody-dependent enhancement Antigen ... immune enhancement therapy Autophagy Beta-2 microglobulin Binding antibody Biological response modifiers Blocking antibody ... Molecular mimicry Monoclonal antibody Monoclonal antibody therapy Monokine Mononuclear phagocyte system Monospecific antibody ... antibodies Polyclonal B cell response Polymersome Pox party Precipitin Premunition Premunity Primary and secondary antibodies ...
https://en.wikipedia.org/wiki/Index_of_immunology_articles
CD32CD32
Having too little CD32B has been associated with dysregulated antibody function, as well as increased antibody-dependent ... this is attributed to an enhancement of FcR-dependent phagocytic functions. CD32B imbalance is also associated with ... When expressed, CD32C plays an important role in the activation of antibody-dependent cell cytotoxicity (ADCC). Animal studies ... CD32 has a low-affinity for the Fc region of IgG antibodies in monomeric form, but high affinity for IgG immune complexes. CD32 ...
https://en.wikipedia.org/wiki/CD32
Fc receptorFc receptor
... by a mechanism known as antibody-dependent enhancement of infection. There are several different types of Fc receptors ( ... or infected cells by antibody-mediated phagocytosis or antibody-dependent cell-mediated cytotoxicity. Some viruses such as ... This process is known as antibody-dependent cell-mediated cytotoxicity (ADCC). FcγRIII on NK cells can also associate with ... Another process involving Fc receptors is called antibody-dependent cell-mediated cytotoxicity (ADCC). During ADCC, FcγRIII ...
https://en.wikipedia.org/wiki/Fc_receptor
Donor-specific antibodyDonor-specific antibody
Lymphocyte-dependent antibody and renal graft rejection.. Lancet. 1975; 1(7913):953-4. Tinckam KJ. Basic histocompatibility ... Mechanisms of immunologic enhancement. Transplant Proc. 1970; 2(1):68-75. Kerman RH, Kimball PM, Van Buren CT, Lewis RM, DeVera ... Similarly, false negative results are possible as this is purely complement dependent that requires higher antibody titres to ... Donor-specific antibodies (DSA) are a concept in transplantation medicine and describe the presence of antibodies specific to ...
https://en.wikipedia.org/wiki/Donor-specific_antibody
Lyme diseaseLyme disease
The OspC antibodies kill any of the bacteria that have not been killed by the OspA antibodies. Canine Recombinant Lyme, ... The specific approach to their use is dependent on the individual affected and the stage of the disease. For most people with ... burgdorferi in ticks and for enhancement of spirochetemia in mice". Cell. 89 (7): 1111-9. doi:10.1016/S0092-8674(00)80298-6. ... IgM and IgG antibody levels may be elevated for years even after successful treatment with antibiotics. As antibody levels are ...
https://en.wikipedia.org/wiki/Lyme_disease
Lipid bilayer fusionLipid bilayer fusion
Fluorescence enhancement assays with Tb3+/DPA: This method is based on the fact that chelate of Tb3+/DPA is 10,000 times more ... The resulting "hybridoma" from this combination expresses a desired antibody as determined by the B-cell involved, but is ... Assays evaluating lipid mixing make use of concentration dependent effects such as nonradiative energy transfer, fluorescence ... Köhler, G.; Milstein, C. (1975). "Continuous cultures of fused cells secreting antibody of predefined specificity". Nature. 256 ...
https://en.wikipedia.org/wiki/Lipid_bilayer_fusion
SuperantigenSuperantigen
... on priming and effector stages of a T cell-dependent antibody response". Eur. J. Immunol. 24 (2): 445-9. doi:10.1002/eji. ... Schlievert PM (April 1982). "Enhancement of host susceptibility to lethal endotoxin shock by staphylococcal pyrogenic exotoxin ... Immunoglobulin pools are able to neutralize specific antibodies and prevent T-cell activation. Synthetic antibodies and ... Similar endogenous SAg-dependent selection has yet to be identified in the human genome, but endogenous SAgs have been ...
https://en.wikipedia.org/wiki/Superantigen
Potential applications of graphenePotential applications of graphene
Therefore, the combination of HSA-NPs and GO-NSs could be useful for reducing the cytotoxicity of GO-NSs and the enhancement of ... Thermally dependent resistivity in mesoscopic copper wire limits efficiency and current carrying capacity in small-scale ... The sensors bind to 8-hydroxydeoxyguanosine (8-OHdG) and is capable of selective binding with antibodies. The presence of 8- ... Majumder, M; Tkacz, R; Oldenbourg, R; Mehta, S; Miansari, M; Verma, A (2014). "pH dependent isotropic to nematic phase ...
https://en.wikipedia.org/wiki/Potential_applications_of_graphene
Radiation therapyRadiation therapy
An enhancement of virtual simulation is 3-dimensional conformal radiation therapy (3DCRT), in which the profile of each ... Targeting can also be achieved by attaching the radioisotope to another molecule or antibody to guide it to the target tissue. ... Side effects are dose- dependent; for example higher doses of head and neck radiation can be associated with cardiovascular ... The increase is dose dependent, related to the RT's dose strength, volume and location. Cardiovascular late side effects have ...
https://en.wikipedia.org/wiki/Radiation_therapy
TuftsinTuftsin
The enhancement of antitumour immune response by immunomodulators is capable of stimulating reticuloendothelial and T-cell- ... Maximal effect was measured at tuftsin concentration 5 x 10−8 M. This process is highly specific and dependent on the ... Conjugates with polytuftsin retain tuftsin-like effects and increase the epitope specific antibody production. Tuftsin sequence ... The number of antigen-forming cells increases following injections of tuftsin T-dependent antigen. Tuftsin enhances the antigen ...
https://en.wikipedia.org/wiki/Tuftsin
CannabinoidCannabinoid
These metabolites are the chemicals recognized by common antibody-based "drug tests"; in the case of THC or others, these loads ... Next, CBGA is independently converted to either CBG, THCA, CBDA or CBCA by four separate synthase, FAD-dependent dehydrogenase ... 1994) summed up the phenomenon of gustatory enhancement by certain cannabinoids. The sweet receptor (Tlc1) is stimulated by ... Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects". The Journal of Biological Chemistry. 281 (20 ...
https://en.wikipedia.org/wiki/Cannabinoid
HIST1H4DHIST1H4D
2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312-26. doi:10.1006/viro. ... Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". ... and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J ...
https://en.wikipedia.org/wiki/HIST1H4D
Epithelioid sarcomaEpithelioid sarcoma
This reactivation of AKT has been shown to be c-MET-dependent, resulting in the rationale that blocking both mTOR and c-MET ... They can also include the administration of laboratory-produced antibodies specific to tumor antigens to create or boost an ... "Autologous immune enhancement therapy against an advanced epithelioid sarcoma: A case report". Oncology Letters. 5 (5): 1457- ... Cyclin D-1 is a regulator of cyclin-dependent kinases (CDK4 and CDK6). It has been shown to interact with the retinoblastoma ...
https://en.wikipedia.org/wiki/Epithelioid_sarcoma
Protein engineeringProtein engineering
The most common example for multivalent binding are the antibodies, and there is extensive research for bispecific antibodies. ... Further functional enhancements may be included in future simulations by integrating protein dynamics. Biochemical and ... Cloning performed in yeast involves PCR dependent reassembly of fragmented expression vectors. These reassembled vectors are ... Applications of bispecific antibodies cover a broad spectrum that includes diagnosis, imaging, prophylaxis, and therapy. In ...
https://en.wikipedia.org/wiki/Protein_engineering
Surface plasmon resonanceSurface plasmon resonance
Light intensity enhancement is a very important aspect of LSPRs and localization means the LSPR has very high spatial ... Additionally, it allows the mapping of epitopes as antibodies of overlapping epitopes will be associated with an attenuated ... described by a frequency-dependent relative permittivity between the external medium and the surface. This quantity, hereafter ... individual steps in sequential binding events can be thoroughly assessed when investigating the suitability between antibodies ...
https://en.wikipedia.org/wiki/Surface_plasmon_resonance
Bacillus subtilisBacillus subtilis
Smaldone GT, Antelmann H, Gaballa A, Helmann JD (May 2012). "The FsrA sRNA and FbpB protein mediate the iron-dependent ... "Genomic signatures of strain selection and enhancement in Bacillus atrophaeus var. globigii, a historical biowarfare simulant ... been found to significantly stimulate broad-spectrum immune activity including activation of secretion of specific antibodies ...
https://en.wikipedia.org/wiki/Bacillus_subtilis
Reproductive immunologyReproductive immunology
... produced antibodies against hCG in the small group of women immunized. The anti-hCG antibodies generated were capable of ... for their possible enhancement of responses. Studying the female reproductive tract, especially in humans, allows for a better ... "Prenatal immune programming of the sex-dependent risk for major depression". Translational Psychiatry. 6 (5): e822. doi:10.1038 ... The presence of anti-sperm antibodies in infertile men was first reported in 1954 by Rumke and Wilson. It has been noticed that ...
https://en.wikipedia.org/wiki/Reproductive_immunology
Hookworm infectionHookworm infection
The incubation period can vary between a few weeks to many months, and is largely dependent on the number of hookworm parasites ... Additionally, both malaria and helminth infection can cause anemia, but the effect of co-infection and possible enhancement of ... Therefore, a vaccine that could induce antibodies for these antigens could interfere with the hookworm's digestive pathway and ...
https://en.wikipedia.org/wiki/Hookworm_infection
Human T-lymphotropic virusHuman T-lymphotropic virus
... eradicate HTLV-1 in combination with autologous peripheral blood mononuclear cells via antibody-dependent cellular cytotoxicity ... may provide an enhancement of infectivity. Tax expression induces proliferation, inhibits the apoptosis of HTLV-1-infected ... A vaccine candidate that can elicit or boost anti-gp46 neutralizing antibody response may have a potential for prevention and ... Tanaka Y, Takahashi Y, Kodama A, Tanaka R, Saito M (2014). "Neutralizing antibodies against human T cell leukemia virus type-I ...
https://en.wikipedia.org/wiki/Human_T-lymphotropic_virus
Lymphocytic choriomeningitisLymphocytic choriomeningitis
The introduced mouse will seroconvert, allowing use of immunofluorescence antibody (IFA), MFIA or ELISA to detect antibodies. ... The RNA-dependent, RNA-polymerase brought along with the virus initially binds to a promoter on the L and S segments and begins ... The future enhancement of the field of vaccinology will greatly depend on the LCMV model system.[citation needed] LCMV is a ... In one study, antibodies to LCMV were detected in 0.8% of normal infants, 2.7% of infants with neurological signs and 30% of ...
https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis
HIST1H4IHIST1H4I
2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312-26. doi:10.1006/viro. ... Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". ... Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies". FEBS Lett. 253 (1-2): 141 ...
https://en.wikipedia.org/wiki/HIST1H4I
I-motif DNAI-motif DNA
A new antibody fragment was created, and was found to have highly specific binding affinity for I-motif complexes, but did not ... As a nucleic acid structure, i-motif DNA stability is dependent on the nature of the sequence, temperature, and ionic strength ... PCBPs have the ability to play a variety of roles such as stabilizing mRNA and translational repression or enhancement ... However, the overall stability of i-motif structures is dependent on the number of cytosine residues that are interacting with ...
https://en.wikipedia.org/wiki/I-motif_DNA
AmyloidAmyloid
Modern antibody technology and immunohistochemistry has made specific staining easier, but often this can cause trouble because ... Recently, significant enhancement of fluorescence quantum yield of NIAD-4 was exploited to super-resolution fluorescence ... Bae S, Lim E, Hwang D, Huh H, Kim SK (2015). "Torsion-dependent fluorescence switching of amyloid-binding dye NIAD-4". Chemical ... and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP ...
https://en.wikipedia.org/wiki/Amyloid
Hsp70Hsp70
December 2012). "CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression". Cell. 151 (6): ... July 2013). "Evidence of a role for both anti-Hsp70 antibody and endothelial surface membrane Hsp70 in atherosclerosis". Cell ... "HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical ... Similarly, Hsp70 overexpression suppressed poly-Q dependent aggregation and neurodegeneration in cell cultures, yeast, fly, and ...
https://en.wikipedia.org/wiki/Hsp70
NanomaterialsNanomaterials
Size-dependent properties are observed such as quantum confinement in semiconductor particles, surface plasmon resonance in ... "targeted nanoprobe functionalized with an anti-folate-receptor antibody (αFR-Ab) via a PEG-maleimide-succinimide and using the ... on the Nano scale has allowed the development of imaging probes with multi-functionality such as better contrast enhancement, ... So, it is generally dependent on material behavior and their bonding as well. The reason why mechanical properties of ...
https://en.wikipedia.org/wiki/Nanomaterials
ApoptosisApoptosis
In order to be released, the protein is cleaved by a calcium-dependent calpain protease. Biology portal Anoikis Apaf-1 Apo2.7 ... these mice demonstrated a deficiency in the maturation of an antibody response; they were able to generate normal levels of IgM ... resulting in the increase of p53 protein level and enhancement of cancer cell-apoptosis. p53 prevents the cell from replicating ... April 2010). "Apoptosis induced by Oropouche virus infection in HeLa cells is dependent on virus protein expression". Virus ...
https://en.wikipedia.org/wiki/Apoptosis
Staphylococcus aureusStaphylococcus aureus
Lack of antibody to TSST-1 plays a part in the pathogenesis of TSS. Other strains of S. aureus can produce an enterotoxin that ... In conclusion, there is evidence that any strain of this bacterium can become invasive, as this is highly dependent upon human ... McLaughlin RA, Hoogewerf AJ (August 2006). "Interleukin-1beta-induced growth enhancement of Staphylococcus aureus occurs in ... Host antibodies are less effective for S. aureus biofilm due to the heterogeneous antigen distribution, where an antigen may be ...
https://en.wikipedia.org/wiki/Staphylococcus_aureus
Flow Cytometric Determination for Dengue Virus-Infected Cells:Its Application for Antibody-Dependent Enhancement Study.Flow Cytometric Determination for Dengue Virus-Infected Cells:Its Application for Antibody-Dependent Enhancement Study.
... ... 2005)‎. Flow Cytometric Determination for Dengue Virus-Infected Cells:Its Application for Antibody-Dependent Enhancement Study ...
https://extranet.who.int/iris/restricted/handle/10665/164129
antibody dependent enhancements<...antibody dependent enhancements<...
Blog, calreticulin antibody, fam175a, ferrostatin, frap assay, Mc4 Receptor, Order Dna Primers, Peg Precipitation, polystain, ...
https://www.hivinsite.com/tag/antibody-dependent-enhancements/
antibody dependent enhancement (ADE) - Vision Timesantibody dependent enhancement (ADE) - Vision Times
Vision Times tells the world everything about China in todays context. We keep a close eye on China because of its influence now and the lessons we can learn from its ancient past to better our lives today ...
https://www.visiontimes.com/tag/antibody-dependent-enhancement-ade
antibody dependent enhancementantibody dependent enhancement
Tagged as: Andrew Wakefield, antibody, antibody dependent enhancement, Autism, brain organoids, measles, microcephaly, mmr, ... antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. ... Tagged as: antibody dependent enhancement, dengue, DHF/DSS, Fc receptor, flavivirus, fucosylation, viral, virology, virus, ... Tagged as: antibody dependent enhancement, dengue virus, DNA vaccine, microcephaly, Olympics, placenta, sexual transmission, ...
https://www.microbe.tv/twiv/tag/antibody-dependent-enhancement/
Covid negative patients are overwhelming hospitals, exactly as predicted with Antibody Dependent EnhancementCovid "negative" patients are overwhelming hospitals, exactly as predicted with Antibody Dependent Enhancement
It would appear as though the fully jabbed in that country are experiencing antibody-dependent enhancement (ADE) or some other ... vaccines genocide vaccination Vaccine deaths vaccine injury hospitals overrun pandemic death antibodies vaccine wars COVID ...
https://www.afinalwarning.com/569618.html
antibody-dependent enhancement Archives - Seemorerocks
... antibody-dependent enhancement. Covering up Antibody-Dependent Enhancement in the UK Covering up Antibody-Dependent Enhancement ... DR RICHARD FLEMING ON ANTIBODY-DEPENDENT ENHANCEMENT DR RICHARD FLEMING ON ANTIBODY-DEPENDENT ENHANCEMENT October 4, 2021 admin ... Medical journal confirms ANTIBODY-DEPENDENT ENHANCEMENT in the vaccinated Medical journal confirms ANTIBODY-DEPENDENT ... PENTAGON DATA ANALYSIS SHOWS ANTIBODY DEPENDENT ENHANCEMENT WORSENS OVER TIME PENTAGON DATA ANALYSIS SHOWS ANTIBODY DEPENDENT ...
https://seemorerocks.is/tag/antibody-dependent-enhancement/
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https://www.yeastevolution.com/tag/antibody-dependent-enhancement-reaction/
Antibody Dependent Enhancement and Autoimmune DiseaseAntibody Dependent Enhancement and Autoimmune Disease
The Medical Science Facts behind the Covid-Sars 2-Coronavirus Immunisation Agenda Dr Sherri Tenpenny Exposes 10 Deadly Dangers of Pfizer/Johnson & Johnson Covid-19 Fake-Vaccines Medical Doctor Exp...
https://odysee.com/@sirebard:4/Let
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... *antibody dependent enhancements. *antibody dependent enhancement virus. *antibody ...
https://www.sikopharma.at/tag/antibody-dependent-enhancement-reaction/
AFM Task Force Report | Board of Scientific Counselors | CDCAFM Task Force Report | Board of Scientific Counselors | CDC
Diagnostic (intrathecal), pathogenic antibodies (autoantibodies). *Antibody-dependent enhancement. Support for broad approaches ... Support for measuring antibody response to infection in serum and CSF. * ... Kinetics of disease suggest that antibody-mediated pathology is unlikely. *Low priority given to measuring autoantibody ...
https://www.cdc.gov/ddid/bsc/afm-report.html
antibody dependent enhancement risk<...antibody dependent enhancement risk<...
Zeb2 Antibody Tags. antibody-drug conjugates antibody definition antibody infusion antibody infusion treatment antibody screen ... antibody structure antibody testing antibody tests antibody treatment gerbil cages gerbil food gerbilling guinea-bissau guinea ...
https://www.expressionpathology.com/tag/antibody-dependent-enhancement-risk/
Nobel Prize winner says covid vaccination is an unacceptable mistake thats spreading variants - NaturalNews.comNobel Prize winner says covid vaccination is an "unacceptable mistake" that's spreading "variants" - NaturalNews.com
... as antibody-dependent enhancement takes hold. Pfizer, FDA have known for decades that antibody-dependent enhancement occurs in ... Tags: antibody-dependent enhancement, badhealth, badmedicine, badscience, coronavirus, COVID, Fauci, HIV, infections, Luc ... More news on antibody-dependent enhancement JABBED UNTIL DEATH: Endless mRNA jabs are now planned for multiple vaccine types, ... Many other epidemiologists and virologists are choosing to remain "silent" about the "antibody-dependent enhancement" that ...
https://naturalnews.com/2021-05-21-nobel-prize-winner-covid-vaccination-unacceptable-mistake.html
What are antibodies? What are antibodies?
This is antibody-dependent enhancement.. Antibody-dependent enhancement and mosquito-borne viruses. There are hundreds of ... Antibody-dependent enhancement was first recognised to occur in humans with dengue in 1977; researchers noticed the disease was ... Due to the cross-reactivity and antibody-dependent enhancement potential for these two viruses, ensuring Zika and dengue ... Researchers recently tested whether Zika could be capable of eliciting this antibody-dependent enhancement for dengue. The ...
https://www.sydney.edu.au/news-opinion/news/2016/11/11/what-are-antibodies-.html
تصفح Regional Journals حسب العنوان
Flow Cytometric Determination for Dengue Virus-Infected Cells:Its Application for Antibody-Dependent Enhancement Study.  Lei, ...
https://apps.who.int:80/iris/handle/10665/136787/browse?locale-attribute=ar&type=title&etal=-1&starts_with=F&sort_by=1&rpp=20&order=ASC
Antibody-Dependent Enhancement Activity of a Plant-Made Vaccine against West Nile Virus. | Vaccines (Basel);11(2)2023 Jan 17. ...Antibody-Dependent Enhancement Activity of a Plant-Made Vaccine against West Nile Virus. | Vaccines (Basel);11(2)2023 Jan 17. ...
West Nile virus (WNV); Zika virus (ZIKV); antibody-dependent enhancement (ADE); dengue virus (DENV); domain III (DIII); plant- ... Antibody-Dependent Enhancement Activity of a Plant-Made Vaccine against West Nile Virus. ... Antibody-Dependent Enhancement Activity of a Plant-Made Vaccine against West Nile Virus. ... is the risk of increasing infection by related flaviviruses in vaccinated subjects via antibody-dependent enhancement of ...
https://pesquisa.bvsalud.org/portal/resource/pt/mdl-36851075
Fauci Knew the Vaxines Would Cause Antibody Dependent Enhancement and Make Things Worse - London TimesFauci Knew the Vaxines Would Cause Antibody Dependent Enhancement and Make Things Worse - London Times
Fauci Knew the Vaxines Would Cause Antibody Dependent Enhancement and Make Things Worse ... Fauci Knew the Vaxines Would Cause Antibody Dependent Enhancement and Make Things Worse. ... Fauci Knew the Vaxines Would Cause Antibody Dependent Enhancement and Make Things Worse. ... Fauci Knew the Vaxines Would Cause Antibody Dependent Enhancement and Make Things Worse ...
https://www.londontimes.live/health/fauci-knew-the-vaxines-would-cause-antibody-dependent-enhancement-and-make-things-worse/
Neutralizing Antibody Response and SARS Severity - Volume 11, Number 11-November 2005 - Emerging Infectious Diseases journal -...
Furthermore, the nonneutralizing antibodies are known to facilitate viral infection, termed antibody-dependent enhancement (ADE ... Antibody-dependent enhancement of viral infectivity. Adv Virus Res. 1986;31:335-55. DOIPubMedGoogle Scholar ... Antibody-dependent enhancement of viral infection: molecular mechanisms and in vivo implications. Rev Med Virol. 2003;13:387-98 ... Antibody-dependent enhancement of feline infectious peritonitis virus infection in feline alveolar macrophages and human ...
https://wwwnc.cdc.gov/eid/article/11/11/04-0659
Neutralizing monoclonal antibodies for treatment of COVID-19Neutralizing monoclonal antibodies for treatment of COVID-19
Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been ... Antibodies, Neutralizing / therapeutic use* * Antibodies, Viral / therapeutic use* * Antibody-Dependent Enhancement * COVID-19 ... Neutralizing monoclonal antibodies for treatment of COVID-19 Nat Rev Immunol. 2021 Jun;21(6):382-393. doi: 10.1038/s41577-021- ... Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been ...
https://pubmed.ncbi.nlm.nih.gov/33875867/?dopt=Abstract
SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE) -...SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE) -...
SARS-CoV-2 immunization strategies to enhance protective immunity with reduced risk of antibody-dependent enhancement (ADE). ... while eliminating the risk associated with the so-called antibody-dependent enhancement (ADE). The gathered investigative team ...
https://cancovid.ca/fr/grant/sars-cov-2-immunization-strategies-to-enhance-protective-immunity-with-reduced-risk-of-antibody-dependent-enhancement-ade/
Controlling the SARS-CoV-2 spike glycoprotein conformation | Nature Structural & Molecular BiologyControlling the SARS-CoV-2 spike glycoprotein conformation | Nature Structural & Molecular Biology
Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with ... HIV vaccine design to target germline precursors of glycan-dependent broadly neutralizing antibodies. Immunity 45, 483-496 ( ... Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies. Cell 182 ... Complicating factors, such as a potential for antibody-induced enhancement, may favor the use of truncated, single-domain ...
https://www.nature.com/articles/s41594-020-0479-4?error=cookies_not_supported&code=83ea6a1b-6aba-4c30-9669-5b2b21f0dd4f
Antibody-Dependent Enhancement: Covid-19 Case/Hospitalisation/Death Rates now highest among Triple Vaccinated in Trudeaus...Antibody-Dependent Enhancement: Covid-19 Case/Hospitalisation/Death Rates now highest among Triple Vaccinated in Trudeau's...
Antibody-Dependent Enhancement: Covid-19 Case/Hospitalisation/Death Rates now highest among Triple Vaccinated in Trudeaus ...
https://wirralinittogether.blog/2022/05/12/antibody-dependent-enhancement-covid-19-case-hospitalisation-death-rates-now-highest-among-triple-vaccinated-in-trudeaus-canada/
Breaking: Recently Unredacted Documents Prove Pfizer & FDA Knew Antibody-Dependent Enhancement Occurring in Vaccinated - By the...Breaking: Recently Unredacted Documents Prove Pfizer & FDA Knew Antibody-Dependent Enhancement Occurring in Vaccinated - By the...
... www.infowars.com/posts/internal-documents-prove-pfizer-fda-knew-antibody-dependent-enhancement-occurring-in-vaccinated/ ... Breaking: Recently Unredacted Documents Prove Pfizer & FDA Knew Antibody-Dependent Enhancement Occurring in Vaccinated. On ... One thought on "Breaking: Recently Unredacted Documents Prove Pfizer & FDA Knew Antibody-Dependent Enhancement Occurring in ... Pingback: Breaking: Recently Unredacted Documents Prove Pfizer & FDA Knew Antibody-Dependent Enhancement Occurring in ...
https://bythebloodofthelamb.wordpress.com/2022/04/06/breaking-recently-unredacted-documents-prove-pfizer-fda-knew-antibody-dependent-enhancement-occurring-in-vaccinated/
Aleutian mink disease parvovirus infection of mink macrophages and human macrophage cell line U937: Demonstration of antibody...
Vaccines | Free Full-Text | Antibody Responses to SARS-CoV-2 Antigens in Humans and AnimalsVaccines | Free Full-Text | Antibody Responses to SARS-CoV-2 Antigens in Humans and Animals
The correlation of this response with those to other coronaviruses suggests that the antibodies are cross-reactive and ... We conclude that substantial variation in antibody generation against coronavirus proteins will influence interpretations of ... and the antibody’s cross reactivity to other coronaviruses. Using a panel of 37 convalescent COVID-19 human serum samples ... we must first understand the antibody response to individual proteins on the severe acute respiratory syndrome-related ...
https://www.mdpi.com/2076-393X/8/4/684
Crossmatching: Overview, Clinical Indications/Applications, Test PerformanceCrossmatching: Overview, Clinical Indications/Applications, Test Performance
Presence of antibody to an ingredient in the enhancement media or enhancement-dependent autoantibody ... must not have current clinically significant antibodies or a history of clinically significant antibodies found via antibody ... to detect clinically significant antibodies that may have been missed by the antibody screening test. ... The antibody in the recipients serum or plasma is detected when the sensitized donor RBCs react with the anti-immunoglobulin G ...
https://www.medscape.com/answers/1731279-172182/what-is-an-antiglobulin-crossmatch-test
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Antibody-Dependent Enhancement Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Antibody-Dependent+Enhancement&parentid=33571&catid=34789
Friday, 28 February 2020 at 14:14Friday, 28 February 2020 at 14:14
wr: The mechanism is antibody-dependent enhancement. In the first infection, the body mounts a defense, creating waves of ... Upon a second infection, however, the virus is able to use these depleted antibodies as part of the mechanism to open the ... antibodies. They are generally effective, as given by the low death rate. When the infection retreats, the antibodies also drop ...
https://www.outsidethebeltway.com/a-blast-from-the-past-cdc-funding/
DailyMed - SOTROVIMAB injection, solution, concentrateDailyMed - SOTROVIMAB injection, solution, concentrate
Antibody Dependent Enhancement (ADE) of Infection The risk that sotrovimab could mediate viral uptake and replication by immune ... Sotrovimab also elicited antibody-dependent cellular phagocytosis (ADCP) in cell-based assays using CD14+ monocytes targeting ... Sotrovimab exhibited antibody-dependent cell-mediated cytotoxicity (ADCC) in cell culture using isolated human natural killer ( ... It is not known if these events were related to SARS-CoV-2 monoclonal antibody use or were due to progression of COVID‑19. ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=aa5cca2e-4351-4f81-b0e5-3303ac0b2474
Elevated levels of fructosamine are independently associated with SARS-CoV-2 reinfection: A 12-mo follow-up studyElevated levels of fructosamine are independently associated with SARS-CoV-2 reinfection: A 12-mo follow-up study
Role of antibody-dependent enhancement (ADE) in the virulence of SARS-CoV-2 and its mitigation strategies for the development ... Ulrich H, Pillat MM, Tárnok A. Dengue Fever, COVID-19 (SARS-CoV-2), and Antibody-Dependent Enhancement (ADE): A Perspective. ... to induce a cytokine storm[29]. This immunological disorder may increase the occurrence of antibody-dependent enhancement (ADE ... In patients who are positive for coronavirus-specific antibodies or are infected by different virus strains, their antibodies ...
https://www.wjgnet.com/1948-9358/full/v13/i7/543.htm
InfectionVaccineTitersAntigensVaccinesDiscussing Covid-19Monoclonal antibodyResponsesImmunityZikaCOVIDIntrathecalTherapeuticProteinMacrophagesReactionImmune systemCoronavirusSevereBloodstreamVariantsOccursRespiratory syncyDetect2020ImmunoglobulinAntigenResearchersRecognizeDiagnosticResponseInvadersClinicallyVirusDiseaseCellsAcuteTreatmentBloodPatientsCloselyRisk
Infection35
  • Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami. (microbe.tv)
  • The latest Zika virus news from the ConTWiVstadors, including a case of female to male transmission, risk of infection at the 2016 summer Olympics, a DNA vaccine, antibody-dependent enhancement by dengue antibodies, and sites of replication in the placenta. (microbe.tv)
  • A medical journal called "Journal of Infection" has provided the first evidence that Persons who have been VACCINATED against COVID-19 are now subject to Antibody-Dependent Enhancement which has been so talked about by experts as their worst fear. (seemorerocks.is)
  • It is the antibodies produced by the virus that enable an infection to become stronger," he told Pierre Barnérias of Hold-Up Media in an interview earlier this month. (naturalnews.com)
  • Antibodies are produced by the "memory cells" of the immune system so if you are ever challenged by the same infection again, you will be able to recognise it, respond much faster and kill the invaders. (edu.au)
  • In fact, for people infected with the virus, infection is indistinguishable from dengue using classic antibody tests. (edu.au)
  • This made scientists wonder: could prior infection with Zika cause an antibody-dependent enhancement response following dengue infection or vice versa? (edu.au)
  • The findings revealed dengue antibodies can protect against Zika infection or facilitate the infection, depending on which antigens the antibodies attach to. (edu.au)
  • Likewise, prior Zika infection can either protect against or worsen dengue infection via antibody-dependent enhancement. (edu.au)
  • One of the major safety concerns for WNV vaccine development is the risk of increasing infection by related flaviviruses in vaccinated subjects via antibody-dependent enhancement of infection (ADE). (bvsalud.org)
  • Notably, VLP-induced antibodies did not enhance the infection of Fc gamma receptor -expressing K562 cells by ZIKV or DENV through ADE. (bvsalud.org)
  • Thus, a plant -made wDIII-displaying VLP presents a promising WNV vaccine candidate that induces protective immunity and minimizes the concern of inducing ADE-prone antibodies to predispose vaccinees to severe infection by DENV or ZIKV . (bvsalud.org)
  • In the first infection, the body mounts a defense, creating waves of antibodies. (outsidethebeltway.com)
  • When the infection retreats, the antibodies also drop in number. (outsidethebeltway.com)
  • Upon a second infection, however, the virus is able to use these depleted antibodies as part of the mechanism to open the necessary receptors on the membranes of cells. (outsidethebeltway.com)
  • ADE occurs when "the antibodies generated during an immune response recognize and bind to a pathogen, but they are unable to prevent infection. (dissidentvoice.org)
  • The antibody response these vaccines create against the spike protein may be enough to reduce hospitalizations and deaths from COVID, but it is not robust enough to prevent infection in the first place. (hawaiireporter.com)
  • It is meant to help fight an existing infection, and assumes that there are already antibodies from natural immunity that are needing some help in the fight. (hawaiireporter.com)
  • Vaccines in clinical trials have been shown to raise anti-spike antibodies that block virus infection in cells in the lab . (theconversation.com)
  • These antibodies are entering clinical trials to test their ability to prevent infection in those who are exposed, for example, through a household contact. (theconversation.com)
  • During an infection, a dose of these monoclonal antibodies could neutralize virus, giving the immune system a chance to catch up and manufacture its own antibodies to combat the pathogen. (theconversation.com)
  • One side effect seen in the past was antibody-dependent enhancement of infection . (theconversation.com)
  • Professor Ian Henderson, Director of the Institute of Microbiology and Infection at the University of Birmingham, said: 'These patients had an excess of a particular antibody in the bloodstream. (birmingham.ac.uk)
  • Data to date on COVID-19 shows that antibodies can be detected three months after infection, although, as with Sars and Mers, antibodies gradually decrease over time . (sciencealert.com)
  • One way to monitor this would be to assess the antibody response as the type of antibody detected can tell us something about the timing of infection. (sciencealert.com)
  • But unfortunately, antibody results were not analysed in the recent patient's first infection. (sciencealert.com)
  • Currently, neither antibodies nor existing drugs can directly relieve the hemorrhagic fever symptom, and they are usually ineffective when applied later than 4 days after infection (interferon-α at day 1 post-infection combined with an antibody mixture at the fourth day are also effective, but not any later) [ 6 ]. (biomedcentral.com)
  • The immunopathologic phenomenon in which non-neutralizing antibodies produced in response to an initial infection with one serotype remain in circulation and contribute to a more severe clinical outcome upon infection with a second serotype is known as antibody dependent enhancement (ADE) [ 7 ]. (biomedcentral.com)
  • Pascal Soriot, Chief Executive Officer, said: "The long-acting antibody combination has the potential to offer almost immediate protection to those who are not able to be vaccinated, to both prevent infection or treat the disease in patients already infected with the virus. (cision.com)
  • 1-4 The reduced Fc receptor binding aims to minimise the risk of antibody-dependent enhancement of disease - a phenomenon in which virus-specific antibodies promote, rather than inhibit, infection and/or disease. (cision.com)
  • Now, a new NIH-supported study shows that the answer to this question will vary based on how an individual's antibodies against SARS-CoV-2 were generated: over the course of a naturally acquired infection or from a COVID-19 vaccine. (nih.gov)
  • The new evidence shows that protective antibodies generated in response to an mRNA vaccine will target a broader range of SARS-CoV-2 variants carrying "single letter" changes in a key portion of their spike protein compared to antibodies acquired from an infection. (nih.gov)
  • Specifically, antibodies elicited by the mRNA vaccine were more focused to the RBD compared to antibodies elicited by an infection, which more often targeted other portions of the spike protein. (nih.gov)
  • Importantly, the vaccine-elicited antibodies targeted a broader range of places on the RBD than those elicited by natural infection. (nih.gov)
  • It's not entirely clear why these differences in vaccine- and infection-elicited antibody responses exist. (nih.gov)
Vaccine12
  • PENTAGON A.I. CONFIRMS COVID SHOTS TRIGGERING DEADLY ADE IN THE VACCINATED Renowned scientist Dr. Richard Fleming visits Infowars to give a powerful, in-depth Power Point presentation exposing what's really happening with Covid-19 and vaccine induced ADE (Antibody-dependent Enhancement). (seemorerocks.is)
  • Antibody-Dependent Enhancement Activity of a Plant-Made Vaccine against West Nile Virus. (bvsalud.org)
  • In this project, after identifying and engineering the immunogens, we will translate towards SARS-CoV-2 a versatile, potent and immunostimulating nanotechnology platform recently developed in our laboratory, which not only will adequately present the vaccine materiel to the host immune system but also enhance its immunogenicity, while eliminating the risk associated with the so-called antibody-dependent enhancement (ADE). (cancovid.ca)
  • Apparently smoking (and older age) cause lower production or retantion of antibodies when vaccinating with Pfizer vaccine. (cassiopaea.org)
  • Objective We aimed to determine antibody (Ab) titres 3 months after the second dose of the BNT162b2 coronavirus disease-2019 (COVID-19) vaccine and to explore clinical variables predicting these titres in Japan. (cassiopaea.org)
  • A vaccine will protect, in part, by inducing the production of antibodies against the spike protein on the surface of SARS-CoV-2, the virus that causes COVID-19. (theconversation.com)
  • One explanation for this is vaccine-associated enhanced disease, also known as antibody-dependent enhancement, or ADE. (newstarget.com)
  • Which is why Weaver's team's discovery of a zika vaccine that doesn't produce antibodies is big news in the immunology world. (nebraska.edu)
  • After testing their zika experimental vaccine (on the back of a weakened everyday virus), the scientists noticed a healthy response and detected no antibody activity. (nebraska.edu)
  • The lack of antibodies may very well circumvent the potential risks of ADE, resulting in an effective and safer vaccine than those currently in clinical trials," said Weaver. (nebraska.edu)
  • This vaccine works by prompting a person's cells to produce the spike protein, thereby launching an immune response and the production of antibodies. (nih.gov)
  • What's more, antibodies acquired with the help of a vaccine may be more likely to target new SARS-CoV-2 variants potently, even when the variants carry new mutations in the RBD. (nih.gov)
Titers2
  • Specifically, a plant -produced virus -like particle (VLP) that displays the WNV Envelope protein domain III (wDIII) elicited both high neutralizing antibody titers and antigen -specific cellular immune responses in mice . (bvsalud.org)
  • I had come across early studies that showed blood antibody titers diminishing rapidly as each month passed. (ukreloaded.com)
Antigens7
  • Antibodies are made to attach to certain proteins on the surface of an invading organism, called antigens. (edu.au)
  • By sticking to these antigens, antibodies block the invader's ability to replicate, and enter cells, thereby rendering the invader useless. (edu.au)
  • Antibodies may form in response to these antigens, resulting in destruction of donor red blood cells (RBCs), with sequelae leading to clinical manifestations of fever, hypotension, rigors, acute respiratory failure , and acute renal failure . (medscape.com)
  • Binding between the antigens and the antibodies was similar to binding when using commercially available ZIKV Env reagents. (biomedcentral.com)
  • Also, it's possible that mRNA delivery may change the way antigens are presented to the immune system, leading to differences in the antibodies that get produced. (nih.gov)
  • Langerhans cells (LCs) are dendritic epidermal cells whose ability to function as accessory/stimulatory cells in initiating the immune response is, like that of macrophages, dependent on the expression of class II major histocompatibility antigens. (cdc.gov)
  • These results suggest that IFN-gamma may play a role in regulating skin-associated immune responses through enhanced expression of HLA-DR antigens on LCs and that such enhancement may be mediated by alterations in arachidonic acid metabolism. (cdc.gov)
Vaccines3
  • Since the SARS-Cov-2 coronavirus proteins, especially the S-protein, contain many sequences homologous to human proteins [13,36], Covid-19 vaccines can potentially induce the formation of autoreactive antibodies , while long-term maintenance of their synthesis would pose a threat to the body. (cassiopaea.org)
  • The mRNA vaccines from Pfizer and Moderna take a part of the SARS-CoV-2 virus (the spike protein genetic material) and introduce it into the body to elicit antibodies to the spike protein. (hawaiireporter.com)
  • That makes RBD a prime target for both naturally acquired antibodies and those generated by vaccines. (nih.gov)
Discussing Covid-191
  • One such reason - particularly relevant when discussing Covid-19 - is antibody-dependent enhancement (ADE). (dissidentvoice.org)
Monoclonal antibody3
  • Protein expression was verified by mass spectrometry and western-blot with a pan-flavivirus antibody, a ZIKV Env monoclonal antibody and with immune sera from adenoviral (ChAdOx1) ZIKV Env-vaccinated mice. (biomedcentral.com)
  • IFN-gamma effectively induced HLA-DR on both neonatal and adult epidermal LCs and such induction was blocked by neutralization with a murine monoclonal antibody to IFN- gamma. (cdc.gov)
  • The prognosis of HER2-positive breast cancer has dramatically improved because of introduction of trastuzumab, a humanized monoclonal antibody targeting the extracellular domain of HER2. (e-crt.org)
Responses5
  • To answer these questions, there is a need to understand factors such as the kinetics of viral load and its correlation with clinical outcomes, endogenous antibody responses, pharmacokinetic properties of neutralizing mAbs and the potential benefit of combining antibodies to defend against emerging viral variants. (nih.gov)
  • To gain a better insight into the humoral responses in the context of epidemiologic and clinical settings, we analyzed the neutralizing antibody data, along with a variety of epidemiologic elements in the database. (cdc.gov)
  • IgE-induced mast cell degranulation in vivo is often followed by a late-phase reaction (LPR), a second wave of hypersensitivity responses occurring many hours after the acute reaction and dependent upon eosinophils. (jci.org)
  • CONCLUSIONS These findings imply that LC produced increased neutralizing antibody responses than those with HC. (bvsalud.org)
  • The effect of anti-HMGB1 neutralizing antibody on the inflammatory and behavioral responses to tibial surgery were investigated. (asahq.org)
Immunity1
  • Of course, antibody levels are not the only indication of immunity and don't tell us about T lymphocytes or our memory cells. (sciencealert.com)
Zika4
  • Researchers recently tested whether Zika could be capable of eliciting this antibody-dependent enhancement for dengue. (edu.au)
  • That hijacking, called antibody-dependent enhancement, happens in viral infections that are similar to COVID-19, like SARS and MERS, as well as Zika and Dengue. (rochester.edu)
  • To understand how to prevent zika virus, you first need to understand antibodies. (nebraska.edu)
  • The issue at hand: When a person who has already had dengue fever contracts zika virus, antibodies stop playing nice. (nebraska.edu)
COVID7
  • SARS-CoV-2 monoclonal antibodies may be associated with worse clinical outcomes when administered to hospitalized patients with COVID‑19 requiring high flow oxygen or mechanical ventilation. (nih.gov)
  • In each sample, they will look for antibodies (a crucial part of the immune response) against the virus that causes COVID-19, called SARS-CoV-2, as well as related coronaviruses that cause the common cold, and the SARS-Cov-1 virus that emerged in 2003. (rochester.edu)
  • In the novel coronavirus (nCoV-2019) COVID-19, the incubation period lasts about 7 days when the antibodies are not yet developed. (who.int)
  • AstraZeneca has modified an existing agreement with the US Government to supply up to 500,000 additional doses of AZD7442, a long-acting antibody (LAAB) combination which is in late-stage development for the prevention and treatment of COVID-19. (cision.com)
  • COVID-19, the incubation period lasts about 7 days when infectious diseases such as measles, diarrhoea, measles- the antibodies are not yet developed. (who.int)
  • A key issue as we move closer to ending the pandemic is determining more precisely how long people exposed to SARS-CoV-2, the COVID-19 virus, will make neutralizing antibodies against this dangerous coronavirus. (nih.gov)
  • A nasal spray solution containing human IgG1 antibodies against SARS-CoV-2 (COVITRAP) was developed to strengthen other COVID-19 preventive arsenals. (bvsalud.org)
Intrathecal1
  • Under these circumstances, additional studies such as lumbar puncture for evidence of central nervous system (CNS) inflammation, antinuclear antibodies (ANAs), or intrathecal immunoglobulin (IgG) synthesis may support a diagnosis of SLE over atherosclerotic small vessel disease. (medscape.com)
Therapeutic2
  • Antibody levels are also a factor when calculating the dosage of therapeutic drugs. (worldhealth.net)
  • The professor believes it is possible to apply this technique to therapeutic antibodies. (worldhealth.net)
Protein5
  • When a Y-shaped antibody (green) binds to the spike protein (blue and brown) of the SARS-CoV-2, the coronavirus is unable to infect cells. (theconversation.com)
  • Researchers have shown that antibodies, like those made by the human immune system, bind to the spike protein, neutralize it and prevent the coronavirus from infecting cells in laboratory culture. (theconversation.com)
  • At least seven companies have developed monoclonal antibodies , laboratory-manufactured antibodies that recognize the spike protein. (theconversation.com)
  • The spike protein has many locations where antibodies can bind to and neutralize the virus. (theconversation.com)
  • Researchers have found that by immunizing with the spike protein , high levels of neutralizing antibodies can be produced. (theconversation.com)
Macrophages3
  • Our immune systems are complex but two components are critical: antibodies and macrophages. (edu.au)
  • Then the janitor cells of the immune system (macrophages, literally "big eaters"), search around for these "useless invaders" attached to antibodies, engulf them and chop them up for re-use or excretion. (edu.au)
  • However, some viruses actually get inside macrophages, using the antibodies as a Trojan horse. (edu.au)
Reaction1
  • The donor unit is deemed incompatible for transfusion, and the antibody responsible for the reaction should be identified. (medscape.com)
Immune system1
  • In contrast to the protective effect normally associated with antibody, in these patients the antibody stopped the immune system killing the Pseudomonas aeruginosa bacterium and this worsened the patients' lung disease. (birmingham.ac.uk)
Coronavirus3
  • Several neutralizing monoclonal antibodies (mAbs) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed and are now under evaluation in clinical trials. (nih.gov)
  • There have been a number of reports of rapid disappearance of antibodies for SARS-Cov-2 coronavirus in those who have contracted the disease. (cassiopaea.org)
  • Getting rid of such antibodies after the body has been cleared of the coronavirus appears to be its protective and necessary response. (cassiopaea.org)
Severe3
  • researchers noticed the disease was more severe in children who received maternal antibodies for dengue or adults who had previously been infected with a different type of dengue (serotype). (edu.au)
  • Researchers then tested this hypothesis experimentally in monkeys and found the disease to be more severe when the monkeys had been "immunised" with maternal antibodies against dengue. (edu.au)
  • Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. (cdc.gov)
Bloodstream2
  • Perhaps counter intuitively, we decided to remove this antibody from the bloodstream and the outcomes were wholly positive. (birmingham.ac.uk)
  • When used as a delivery system, these computers will be able to decide how much medicine to release into the bloodstream, based on the antibodies in the bloodstream. (worldhealth.net)
Variants2
  • It is clear that the new variants are created by antibody-mediated selection due to the vaccination. (naturalnews.com)
  • In their new study, published in the journal Science Translational Medicine , Bloom, Greaney, and colleagues looked again to the thousands of possible RBD variants to understand how antibodies might be expected to hit their targets there [1]. (nih.gov)
Occurs2
  • Many other epidemiologists and virologists are choosing to remain "silent" about the "antibody-dependent enhancement" that occurs after people are injected with these chemical cocktails. (naturalnews.com)
  • This occurs when antibodies don't neutralize the virus but instead allow it to enter into cells via a receptor intended for antibodies. (theconversation.com)
Respiratory syncy1
  • Here, we review the precedent for passive immunization and lessons learned from using antibody therapies for viral infections such as respiratory syncytial virus, Ebola virus and SARS-CoV infections. (nih.gov)
Detect3
  • The type and screen are the first pretransfusion compatibility tests performed, and they are used to identify the patient's ABO group and Rh type as well as to detect expected and unexpected antibodies in the patient's serum, respectively. (medscape.com)
  • It serves two purposes: (1) to serve as a final check of ABO compatibility between donor red blood cells (RBCs) and patient plasma or serum and (2) to detect clinically significant antibodies that may have been missed by the antibody screening test. (medscape.com)
  • With DNA nano-computers able to detect and measure antibodies while performing complex analyses, researchers are hopeful machines can be programmed to carry out actions in response to certain measurements. (worldhealth.net)
20201
  • Discovered by Vanderbilt University Medical Center and licensed to AstraZeneca in June 2020 , the human monoclonal antibodies were optimised by AstraZeneca with half-life extension and reduced Fc receptor binding. (cision.com)
Immunoglobulin1
  • The antibody in the recipient's serum or plasma is detected when the sensitized donor RBCs react with the anti-immunoglobulin G (IgG) in the microtube during centrifugation. (medscape.com)
Antigen3
  • In an antiglobulin crossmatch performed using the column agglutination system, the donor RBCs, suspended in a hypotonic buffered saline solution, are mixed with the recipient's serum or plasma to allow antigen-antibody interaction in the upper chamber of the microtube. (medscape.com)
  • Atopy, meaning "strange disease," was used by Coca to describe antigen-specific reactions with apparent immunological specificity for which no precipitating antibodies could be identified in plasma. (jci.org)
  • Interferon enhancement of HLA-DR antigen expression on epidermal Langerhans cells. (cdc.gov)
Researchers2
  • Researchers from the University of Birmingham and Newcastle University found that the unusual approach of removing antibodies from the blood stream reduced the effects of chronic infections, the requirement for days spent in hospital and the use of antibiotics. (birmingham.ac.uk)
  • Researchers develop the first DNA computer capable of pinpointing several antibodies in the blood and carrying through resultant calculations. (worldhealth.net)
Recognize1
  • Professor Merkx's method adds the ability to recognize the presence of antibodies. (worldhealth.net)
Diagnostic1
  • In previously undiagnosed patients thought to have SLE, the principal diagnostic study is the antinuclear antibody (ANA) test. (medscape.com)
Response3
  • Patients with a longer illness showed a lower neutralizing antibody response than patients with a shorter illness duration (p = 0.008). (cdc.gov)
  • As antibodies are readily measured in blood, they are often used to indicate a good adaptive immune response. (sciencealert.com)
  • In both cases, RBD-directed antibodies are acquired from the immune system's recognition and response to viral spike proteins. (nih.gov)
Invaders1
  • Lymphocytes come in two main varieties: B lymphocytes, which make antibodies , and T lymphocytes, which include cells that directly kill the germy invaders. (sciencealert.com)
Clinically1
  • When a positive ANA result is thought to be clinically relevant, follow up with an antibody to native, double-stranded DNA (dsDNA antibody) to confirm the diagnosis of SLE. (medscape.com)
Virus5
  • Flow Cytometric Determination for Dengue Virus-Infected Cells:Its Application for Antibody-Dependent Enhancement Study. (who.int)
  • The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors. (microbe.tv)
  • This is because the antibodies made against the first virus type help the second virus to enter cells, resulting in dengue haemorrhagic fever. (edu.au)
  • This has been a concern for other antibody-dependent enhancement viruses such as HIV, Ebola, and Ross River virus. (edu.au)
  • Using a method called deep mutational scanning, the Seattle group's previous study mapped out all possible mutations in the RBD that would change the ability of the virus to bind ACE2 and/or for RBD-directed antibodies to strike their targets. (nih.gov)
Disease4
  • however, in patients who develop the potentially catastrophic complications of DHF and DSS, survival is directly dependent on the hemodynamic support of patient through the disease manifestations. (medscape.com)
  • This is the first description of antibody-dependent enhancement of bacterial disease. (birmingham.ac.uk)
  • Or in scientific terms, antibody-dependent enhancement (ADE) of the disease. (nebraska.edu)
  • The identification and measurement of antibodies is a crucial step in diagnosing and treating disease. (worldhealth.net)
Cells1
  • It might also tell us whether SARS-CoV-2 can hijack antibodies - which usually help you fight off viruses - to instead help it infect more of your cells and make you sicker. (rochester.edu)
Acute1
  • IgE antibodies (but not other isotypes) are capable of passive transfer of both acute and LPR sensitivity to allergen challenge. (jci.org)
Treatment2
  • Monoclonal antibodies may also be effective for treatment. (theconversation.com)
  • The plasmapheresis involved the removal, treatment, and return of blood plasma from circulation and was done 5 times in a week, in order to remove antibody from the patients. (birmingham.ac.uk)
Blood3
  • Crossmatch-incompatible blood is rarely encountered, because donor blood units are selected after an effective antibody screen. (medscape.com)
  • We then replaced antibodies with those from blood donations. (birmingham.ac.uk)
  • However, over time, antibodies levels in our blood wane, but this doesn't necessarily mean protection is lost. (sciencealert.com)
Patients2
  • This is why scientists first have to identify protective antibodies when proposing to use antibody injections to safeguard patients from these types of viruses. (edu.au)
  • AlSaleh et al reported a high prevalence of positive anti-Ro antibodies (52.3%) among their Arab patients, which they felt probably reflected a common characteristic in SLE patients of Middle East origin. (medscape.com)
Closely1
  • I also work closely with a number of SMEs including The Antibody Company and Cuantec, as well as large organisations including Astra Zeneca. (strath.ac.uk)
Risk2
  • BLEMUR, or Bluetooth Low Energy Model of User Risk, is a model of the probability of alert at a given duration and distance of an index case for a specific configuration of settings for an Exposure Notification (EN) system.The Google-Apple EN framework operates in the duration and Bluetooth Low Energy (BLE) signal attenuation domains. (mit.edu)
  • This lessens the risk of enhancement. (theconversation.com)
AFM Task Force Report | Board of Scientific Counselors | CDC
AFM Task Force Report | Board of Scientific Counselors | CDC (cdc.gov)
تصفح Regional Journals حسب العنوان
تصفح Regional Journals حسب العنوان (apps.who.int:80)
Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases journal - CDC
Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases journal - CDC (cdc.gov)
What are antibodies?
What are antibodies? (sydney.edu.au)
CDC Acute Flaccid Myelitis Update, May 2019 | Board of Scientific Counselors | CDC
CDC Acute Flaccid Myelitis Update, May 2019 | Board of Scientific Counselors | CDC (cdc.gov)
Figure 6 - Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases...
Figure 6 - Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases... (wwwnc.cdc.gov)
Figure 4 - Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases...
Figure 4 - Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases... (wwwnc.cdc.gov)
Figure 5 - Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases...
Figure 5 - Severe Dengue Epidemics in Sri Lanka, 2003-2006 - Volume 15, Number 2-February 2009 - Emerging Infectious Diseases... (wwwnc.cdc.gov)
Dengue 1 Virus and Dengue Hemorrhagic Fever, French Polynesia, 2001 - Volume 15, Number 8-August 2009 - Emerging Infectious...
Dengue 1 Virus and Dengue Hemorrhagic Fever, French Polynesia, 2001 - Volume 15, Number 8-August 2009 - Emerging Infectious... (wwwnc.cdc.gov)
PDF) COVID-19 Immunopathology, Particle Pollution, and Iron Balance
PDF) COVID-19 Immunopathology, Particle Pollution, and Iron Balance (researchgate.net)
Search
Search (extranet.who.int)
العربية
العربية (extranet.who.int)
Crossmatching: Overview, Clinical Indications/Applications, Test Performance
Crossmatching: Overview, Clinical Indications/Applications, Test Performance (medscape.com)
Dengue Hemorrhagic Fever in Infants: Research Opportunities Ignored - Volume 8, Number 12-December 2002 - Emerging Infectious...
Dengue Hemorrhagic Fever in Infants: Research Opportunities Ignored - Volume 8, Number 12-December 2002 - Emerging Infectious... (wwwnc.cdc.gov)
Friday, 28 February 2020 at 14:14
Friday, 28 February 2020 at 14:14 (outsidethebeltway.com)
DailyMed - SOTROVIMAB injection, solution, concentrate
DailyMed - SOTROVIMAB injection, solution, concentrate (dailymed.nlm.nih.gov)
Elevated levels of fructosamine are independently associated with SARS-CoV-2 reinfection: A 12-mo follow-up study
Elevated levels of fructosamine are independently associated with SARS-CoV-2 reinfection: A 12-mo follow-up study (wjgnet.com)
Paul Offit's Biggest Concern About COVID Vaccines
Paul Offit's Biggest Concern About COVID Vaccines (medscape.com)
Plasmapheresis Technique: Plasmapheresis, Complications
Plasmapheresis Technique: Plasmapheresis, Complications (medscape.com)