Helminths
Antibodies
Bloodless Medical and Surgical Procedures
Antibody Specificity
Therapy with Helminths
Intestinal Diseases, Parasitic
Antibody Formation
Antibodies, Neutralizing
Antigens, Helminth
Ancylostomatoidea
Antibody Affinity
Anthelmintics
Fluorescent Antibody Technique
Blood-Nerve Barrier
Antibodies, Anti-Idiotypic
Binding Sites, Antibody
Nematospiroides dubius
Antibodies, Neoplasm
Antibodies, Antinuclear
Cross Reactions
Albendazole
Schistosoma mansoni
Immunoglobulin M
Autoantibodies
Filarioidea
Protozoan Infections
Immunoglobulin G
Neutralization Tests
Molecular Sequence Data
Schistosoma
Antigen-Antibody Reactions
Antibodies, Bispecific
Filariasis
Amino Acid Sequence
Schistosomiasis
Nippostrongylus
Schistosomiasis mansoni
Single-Chain Antibodies
Feces
Antibodies, Blocking
Antigen-Antibody Complex
Immunoglobulin Fab Fragments
Trematoda
Antibodies, Heterophile
Antibodies, Catalytic
Fasciola hepatica
Host-Parasite Interactions
Necator americanus
Th2 Cells
Rabbits
Immunoglobulin A
Immunoglobulin E
Antibodies, Monoclonal, Humanized
Fluorescent Antibody Technique, Indirect
Soil
Immunization
Hybridomas
Nematoda
Immune Sera
Enzyme-Linked Immunosorbent Assay
Parasitic Diseases
Trichinella spiralis
Antibodies, Antiphospholipid
Strongyloides stercoralis
Immunoenzyme Techniques
Cells, Cultured
Prevalence
Ascaris
Blotting, Western
Antigens, Surface
Necatoriasis
Immunization, Passive
Strongyloidiasis
B-Lymphocytes
Trichinellosis
Strongyloidea
Immunoassay
Immunoglobulin Fragments
Mebendazole
Immunohistochemistry
T-Lymphocytes
Immunoblotting
Hymenolepis nana
Radioimmunoassay
Flow Cytometry
Electrophoresis, Polyacrylamide Gel
Ancylostoma
Complement Fixation Tests
Cattle
Ascaris suum
Coinfection
Parasites
Base Sequence
Hemagglutination Tests
Hemagglutination Inhibition Tests
Antibodies, Antineutrophil Cytoplasmic
Fascioliasis
Immunoglobulin Variable Region
Seroepidemiologic Studies
Immunoglobulin Idiotypes
Immunologic Techniques
Vaccination
Sensitivity and Specificity
Toxocariasis
Antigens, Neoplasm
Basophils
Immunosorbent Techniques
Cytokines
Cote d'Ivoire
Haptens
Interleukin-4
Species Specificity
Schistosoma haematobium
Antibody Diversity
Mansonelliasis
Wuchereria bancrofti
Peptide Library
Spiruroidea
Hepatitis C Antibodies
Isoantibodies
Immunoglobulin Isotypes
Immunoglobulins
Antibodies, Monoclonal, Murine-Derived
Glycoproteins
Hepatitis B Antibodies
Immunodiffusion
Combretaceae
Binding, Competitive
Schistosomiasis haematobia
Peptide Fragments
Immunity, Maternally-Acquired
Immunity, Humoral
Parasitic Diseases, Animal
Pregnancy Complications, Parasitic
Complement System Proteins
Lupus Erythematosus, Systemic
Ivermectin
Mice, Inbred Strains
Disease Models, Animal
Hygiene
Antinematodal Agents
Vaccines
Antigens, CD
Mice, Knockout
Autoantigens
Recombinant Fusion Proteins
Amoebozoa
Neglected Diseases
Precipitin Tests
Antigens, Protozoan
Hypersensitivity
Peptides
Toxocara canis
Tropical Medicine
Elephantiasis, Filarial
Ancylostomiasis
Antibody-Dependent Cell Cytotoxicity
Interferon-gamma
Lymphocytes
Neurocysticercosis without detectable specific antibody. (1/1192)
A 19-year-old girl who had lived in India for five years until 1992 was admitted to Hokuto Hospital after general seizures which lasted for fifteen minutes. Cerebral magnetic resonance imaging (MRI) showed a ring-enhanced lesion of 6 mm in diameter in the right parietal lobe. She underwent surgical resection after diagnosis of the brain tumor. Histopathological examinations revealed that the resected tumor was a cysticercus of Taenia solium (T. solium), and we concluded that her seizures were caused by neurocysticercosis. Serological examinations by enzyme-linked immunosorbent assay (ELISA) and immunoblots to detect specific antibody against the glycoproteins of T. solium showed no detectable antibody response. The patient is under careful observation in our out-patient clinic with no medication. (+info)Development of a serologic assay to detect Taenia solium taeniasis. (2/1192)
We developed a serologic assay to identify adult Taenia solium tapeworm carriers using excretory/secretory (TSES) antigens collected from in vitro cultured T. solium tapeworms. To identify taeniasis-specific antigens we used an immunoblot assay with serum samples from T. solium tapeworm carriers and cysticercosis patients. Antigens were identified that reacted with antibodies present in serum samples from taeniasis cases and not with those from cysticercosis patients. Using serum samples collected from persons with confirmed T. solium tapeworm infections, the test was determined to be 95% (69 of 73) sensitive. Serum samples (n = 193) from persons with other parasitic infections, including T. saginata tapeworm infections, do not contain cross-reacting antibodies to TSES, indicating that the assay is 100% specific. These data suggest that the immunoblot assay using TSES antigens can be used to identify persons with current or recent T. solium tapeworm infections and provides a new, important tool for epidemiologic purposes, including control and prevention strategies. (+info)Immunity to Chlamydia trachomatis mouse pneumonitis induced by vaccination with live organisms correlates with early granulocyte-macrophage colony-stimulating factor and interleukin-12 production and with dendritic cell-like maturation. (3/1192)
As is true for other intracellular pathogens, immunization with live Chlamydia trachomatis generally induces stronger protective immunity than does immunization with inactivated organism. To investigate the basis for such a difference, we studied immune responses in BALB/c mice immunized with viable or UV-killed C. trachomatis mouse pneumonitis (MoPn). Strong, acquired resistance to C. trachomatis infection was elicited by immunization with viable but not dead organisms. Immunization with viable organisms induced high levels of antigen-specific delayed-type hypersensitivity (DTH), gamma interferon production, and immunoglobulin A (IgA) responses. Immunization with inactivated MoPn mainly induced interleukin-10 (IL-10) production and IgG1 antibody without IgA or DTH responses. Analysis of local early cytokine and cellular events at days 3, 5, and 7 after peritoneal cavity immunization showed that high levels of granulocyte-macrophage colony-stimulating factor and IL-12 were detected with viable but not inactivated organisms. Furthermore, enrichment of a dendritic cell (DC)-like population was detected in the peritoneal cavity only among mice immunized with viable organisms. The results suggest that early differences in inducing proinflammatory cytokines and activation and differentiation of DCs may be the key mechanism underlying the difference between viable and inactivated organisms in inducing active immunity to C. trachomatis infection. (+info)Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep. (4/1192)
The potential of different parasite proteinases for use as vaccine candidates against fascioliasis in sheep was studied by vaccinating animals with the cathepsin L proteinases CL1 and CL2 and with leucine aminopeptidase (LAP) purified from adult flukes. In the first trial, sheep were immunized with CL1 or CL2 and the mean protection levels obtained were 33 and 34%, respectively. Furthermore, a significant reduction in egg output was observed in sheep vaccinated either with CL1 (71%) or with CL2 (81%). The second trial was performed to determine the protective potential of the two cathepsin L proteinases assayed together, as well as in combination with LAP, and of LAP alone. The combination of CL1 and CL2 induced higher levels of protection (60%) than those produced when these enzymes were administered separately. Those sheep that received the cocktail vaccine including CL1, CL2, and LAP were significantly protected (78%) against metacercarial challenge, but vaccination with LAP alone elicited the highest level of protection (89%). All vaccine preparations induced high immunoglobulin G titers which were boosted after the challenge infection, but no correlations between antibody titers and worm burdens were found. However, the sera of those animals vaccinated with LAP contained LAP-neutralizing antibodies. Reduced liver damage, as assessed by the level of the liver enzyme gamma-glutamyl transferase, was observed in the groups vaccinated with CL1, CL2, and LAP or with LAP alone. (+info)Anti-filarial IgG4 in men and women living in Brugia malayi-endemic areas. (5/1192)
To assess whether antifilarial IgG4 can be used to study various epidemiological facets of filarial infections, we studied this isotype in 238 individuals resident in areas endemic for brugian filariasis, focusing on the differences between men and women. In the study area, the prevalence of microfilariae was 6.7% and the prevalence of antifilarial IgG4 was 49.2%. All microfilariae carriers were positive for antifilarial IgG4, whereas a proportion of the endemic normals (94/208) and clephantiasis patients (7/14) had IgG4 antibodies to filarial antigens. Data were analysed as a function of gender in distinct clinical groups and stratified for age. The prevalence of microfilariae was higher in males in all age groups, as reflected in significantly higher antifilarial IgG4 antibody levels compared to females. The prevalence of IgG4 increased to reach a plateau at the age of 30 years in both males and females. These results indicate that antifilarial IgG4 antibodies can reflect the differences in the extent of infection in males and females as measured by microfilarial counts, and that this parameter can be used for epidemiological assessments of filarial infection. (+info)Comparison of serological and parasitological assessments of Onchocerca volvulus transmission after 7 years of mass ivermectin treatment in Mexico. (6/1192)
OBJECTIVE AND METHOD: To compare the utility of an ELISA using 3 recombinant antigens with that of the skin biopsy to estimate incidence of infections in a sentinel cohort of individuals living in an endemic community in southern Mexico during a set of 11 subsequent ivermectin treatments. RESULTS: The apparent community prevalence of infection and microfilarial skin infection before and after 11 treatments with ivermectin plus nodulectomy were 78% and 13%, and 0.68 mf/mg and 0.04 mf/mg, respectively, as measured by skin biopsy. Of a group of 286 individuals participating in all surveys, a sentinel cohort of 42 mf and serologically negative individuals had been followed since 1994. The annual percentage of individuals becoming positive in this cohort was 24% (10/42), 28% (9/33), 0%, and 4.3% (1/23) in 1995, 1996, 1997 and 1998, respectively. Likewise, the incidence in children 5 years and under (n = 13) within this sentinel cohort was 15% (2/13), 18% (2/11), 0% and 11% (1/9), respectively. All individuals became positive to both tests simultaneously, indicating that seroconversion assessed infection incidence as accurately as skin biopsy in the sentinel group. CONCLUSION: Incidence monitoring of a sentinel cohort provides an estimation of the parasite transmission in the community; it is less costly than massive sampling, and a finger prick blood test might be more acceptable in some communities. (+info)Aetiological study of the presumed ocular histoplasmosis syndrome in the Netherlands. (7/1192)
AIM: To investigate whether presumed ocular histoplasmosis syndrome in the Netherlands is caused by Histoplasma capsulatum and whether other risk factors might play a role in the pathogenesis of this syndrome. METHODS: 23 patients were clinically diagnosed as having presumed ocular histoplasmosis syndrome based on the following criteria: peripapillary atrophy, punched out lesions, a macular disciform lesion or scar in one eye without vitritis. As controls, 66 sex and age matched healthy volunteers were used. Serum samples from both patients and controls were tested for the presence of antibodies against H capsulatum, Toxoplasma gondii, Toxocara canis et cati, Ascaris sp, and for the presence of antigens of Cryptococcus neoformans. Serum samples were also tested for the presence of autoantibodies against retinal or choroidal proteins. To investigate other risk factors, patients and controls were asked to fill in a health and travel related questionnaire. Ten patients with ocular toxoplasmosis were used as a disease control group. RESULTS: None of the patients with presumed ocular histoplasmosis syndrome or controls had circulating antibodies directed against H capsulatum. No risk factors could be identified and no indications for autoimmunity and no evidence for the role of the other infectious agents could be demonstrated. CONCLUSIONS: In a Dutch group of patients fulfilling the criteria of a disease currently named presumed ocular histoplasmosis syndrome, no risk factors or relation with the fungus H capsulatum could be detected. (+info)Interleukin-12 as an adjuvant for an antischistosome vaccine consisting of adult worm antigens: protection of rats from cercarial challenge. (8/1192)
Our group previously demonstrated that a detergent extract (fraction S3) prepared from immature (4-week) Schistosoma mansoni parasites can induce partial, serum-transferable immunity to challenge infection in rats when administered as an alum precipitate. In the present study, we examined whether S3 prepared from adult (7-week) worms could similarly induce protection and whether immunity could be positively influenced by treatment with interleukin-12 (IL-12). IL-12 coadministered to Fischer rats and C57BL/6 mice at the time of S3 vaccination altered the prechallenge kinetics of S3-specific antibody titers in both species, ultimately leading to a stable enhancement of titers (relative to those in animals vaccinated without IL-12) in mice but not rats. Immunoblot analysis of prechallenge immune sera demonstrated that IL-12 treatment was associated with changes in the S3 antigen recognition profile in each species. Isotyping of specific antibodies in S3- plus IL-12-vaccinated mice prior to challenge infection revealed a moderate elevation in immunoglobulin G1 (IgG1) responses, strongly enhanced IgG2a and IgG2b responses, as well as diminished total serum IgE responses compared to those in mice given S3 only. In vaccinated rats, IL-12 profoundly suppressed specific IgG1 and enhanced IgG2b responses but did not affect IgG2a responses. S3- plus IL-12-vaccinated rats also produced less total IgE upon challenge infection. Enumeration of worm burdens revealed that vaccination with S3 plus IL-12 conferred 50% protection from cercarial challenge to rats, whereas rats given S3 only were not protected; mice were not protected by S3 vaccination regardless of IL-12 coadministration. The protection observed in S3- plus IL-12-vaccinated rats could not be transferred with serum, suggesting participation of an activated cellular component in the expression of immunity. (+info)The most common types of helminthiasis include:
1. Ascariasis: caused by the roundworm Ascaris lumbricoides, this is one of the most common intestinal parasitic infections worldwide. Symptoms include abdominal pain, diarrhea, and weight loss.
2. Trichuriasis: caused by the whipworm Trichuris trichiura, this infection can cause symptoms such as abdominal pain, diarrhea, and rectal bleeding.
3. Hookworm infection: caused by the hookworm Ancylostoma duodenale or Necator americanus, this infection can cause symptoms such as anemia, abdominal pain, and diarrhea.
4. Strongyloidiasis: caused by the threadworm Strongyloides stercoralis, this infection can cause symptoms such as abdominal pain, diarrhea, and skin rashes.
5. Filariasis: caused by the filarial worms Wuchereria bancrofti, Brugia malayi, and Loa loa, this infection can cause symptoms such as swelling of the limbs, scrotum, and breasts, as well as skin rashes and fever.
Diagnosis of helminthiasis typically involves a physical examination, medical history, and laboratory tests such as stool samples or blood tests to detect the presence of parasites or their eggs. Treatment usually involves antiparasitic drugs, and in some cases, surgery may be necessary to remove worms that have migrated to other parts of the body. Prevention measures include improving sanitation and hygiene, wearing protective clothing when working or traveling in areas with high prevalence of helminthiasis, and using insecticides to prevent mosquito bites.
In conclusion, helminthiasis is a group of diseases caused by parasitic worms that can affect humans and other animals. The most common types of helminthiasis include ascariasis, trichuriasis, hookworm infection, strongyloidiasis, and filariasis. Diagnosis and treatment involve laboratory tests and antiparasitic drugs, respectively. Prevention measures include improving sanitation and hygiene, wearing protective clothing, and using insecticides. Understanding the causes, symptoms, diagnosis, treatment, and prevention of helminthiasis is essential for effective control and management of these diseases.
Some common types of intestinal diseases, parasitic include:
1. Amoebiasis: This is an infection caused by the amoeba Entamoeba histolytica, which can cause diarrhea, abdominal pain, and fever.
2. Giardiasis: This is an infection caused by the parasite Giardia duodenalis, which can cause diarrhea, abdominal cramps, and weight loss.
3. Cryptosporidiosis: This is an infection caused by the parasite Cryptosporidium parvum, which can cause diarrhea, abdominal pain, and fever.
4. Isosporiasis: This is an infection caused by the parasite Isospora belli, which can cause diarrhea, abdominal cramps, and weight loss.
5. Tapeworm infections: These are infections caused by tapeworms, such as Taenia saginata (beef tapeworm) and Dipylidium caninum (dog tapeworm), which can cause abdominal pain, diarrhea, and weight loss.
6. Strongyloidiasis: This is an infection caused by the parasite Strongyloides stercoralis, which can cause diarrhea, abdominal pain, and fatigue.
Intestinal diseases, parasitic can be diagnosed through a combination of physical examination, medical history, and laboratory tests such as stool samples or blood tests. Treatment depends on the specific type of infection and may include antiparasitic medications, anti-diarrheal medications, and supportive care to manage symptoms.
Strongylidae is a family of parasitic nematodes that includes several genera, such as Strongyloides, Ollulanus, and Habronema. These nematodes have a worldwide distribution and can infect a wide range of animals, including humans, cattle, sheep, goats, and horses.
Infection with strongyles can occur through the ingestion of contaminated food or water, or through direct contact with infected animals or their feces. The parasites migrate to the intestines, where they feed on the host's blood and tissues, causing a range of symptoms.
The most common species of strongyles to infect humans are S. stercoralis and S. fuellebornii. Infection with these parasites can lead to a condition known as strongyloidiasis, which can cause a range of symptoms, including:
* Diarrhea
* Weight loss
* Anemia
* Poor appetite
* Abdominal pain
* Fatigue
Strongyloidiasis is typically diagnosed through the detection of parasite eggs in stool samples or through the use of serological tests. Treatment typically involves the use of anthelmintic drugs, which can kill the parasites and alleviate symptoms.
Preventive measures against strongyles include:
* Avoiding contact with infected animals or their feces
* Properly cooking meat before consumption
* Avoiding consumption of raw or undercooked meat
* Maintaining good personal hygiene
* Using clean water and sanitation facilities.
Nematode infections are parasitic infections caused by nematodes, a type of worm. Nematodes are helminths, which are parasites that infect the body and feed on its tissues and fluids. There are several types of nematode infections, including:
1. Ascariasis: This is an infection caused by the roundworm Ascaris lumbricoides. It is one of the most common intestinal parasitic infections in the world and can cause symptoms such as abdominal pain, diarrhea, and weight loss.
2. Trichinellosis: This is an infection caused by the parasite Trichinella. It can be transmitted through the consumption of undercooked meat, particularly pork or wild game. Symptoms include fever, muscle pain, and diarrhea.
3. Strongyloidiasis: This is an infection caused by the roundworm Strongyloides. It can affect people with weakened immune systems, such as those with HIV/AIDS or cancer patients undergoing chemotherapy. Symptoms include diarrhea, abdominal pain, and fatigue.
4. Hookworm infection: This is an infection caused by the hookworm Ancylostoma duodenale. It can be transmitted through contact with contaminated feces or soil. Symptoms include abdominal pain, diarrhea, and anemia.
5. Trichuriasis: This is an infection caused by the whipworm Trichuris trichiura. It can affect people of all ages and can cause symptoms such as diarrhea, abdominal pain, and weight loss.
Nematode infections can be diagnosed through a variety of tests, including stool samples, blood tests, and imaging studies. Treatment depends on the type of infection and may involve medication to kill the parasites, as well as supportive care to manage symptoms. Prevention includes avoiding exposure to contaminated food and water, practicing good hygiene, and using insecticides to control the spread of hookworms.
Overall, nematode infections can have a significant impact on human health, especially in areas with poor sanitation and hygiene. It is important to be aware of these infections and seek medical attention if symptoms persist or worsen over time.
Some common types of protozoan infections include:
1. Malaria: Caused by the Plasmodium parasite, which is transmitted through the bite of an infected mosquito.
2. Giardiasis: Caused by the Giardia parasite, which can be found in contaminated food and water or spread through close contact with an infected person.
3. Amoebiasis: Caused by the Entamoeba parasite, which can infect the intestines and cause symptoms such as diarrhea and abdominal pain.
4. Toxoplasmosis: Caused by the Toxoplasma parasite, which can be spread through contact with contaminated soil or cat feces.
5. Cryptosporidiosis: Caused by the Cryptosporidium parasite, which can be found in contaminated water and can cause symptoms such as diarrhea and stomach cramps.
Protozoan infections are typically treated with antiparasitic medications, and early diagnosis and treatment can help prevent complications and improve outcomes.
The symptoms of filariasis can vary depending on the type of infection and the severity of the disease. In lymphatic filariasis, the most common symptoms are swelling of the limbs, known as elephantiasis, and skin thickening, which can lead to severe social stigma and disability. Other symptoms may include fever, joint pain, and fatigue.
Filariasis is diagnosed through a combination of physical examination, medical history, and laboratory tests such as blood smears or polymerase chain reaction (PCR). Treatment for filariasis typically involves antiparasitic drugs, which can help to reduce the symptoms and prevent complications. However, these drugs do not cure the infection, and repeated treatments may be necessary to control the disease.
Prevention of filariasis primarily involves reducing the population of infected mosquitoes through vector control measures such as insecticide spraying, use of bed nets, and elimination of standing water around homes and communities. Personal protective measures such as wearing protective clothing and applying insect repellents can also help to reduce the risk of infection.
In addition to these measures, there is ongoing research into new diagnostic tools and treatments for filariasis, as well as efforts to eliminate the disease through mass drug administration and other public health interventions.
Keywords: filariasis, lymphatic filariasis, onchocerciasis, loiasis, elephantiasis, swelling, joint pain, fatigue, antiparasitic drugs, vector control, personal protective measures, diagnostic tools, treatments, public health interventions.
Cestode infections are acquired through ingestion of contaminated food or water, or through direct contact with an infected animal or person. Once ingested, the cestodes migrate to the intestine, where they attach themselves to the wall of the intestine and feed on the host's nutrients.
The symptoms of cestode infections can vary depending on the location of the infection and the severity of the infestation. Some common symptoms include:
* Abdominal pain
* Diarrhea
* Weight loss
* Fatigue
* Malnutrition
* Anemia
* Inflammation of the affected organ (e.g., liver or lung)
Cestode infections can be diagnosed through a combination of physical examination, medical history, and laboratory tests such as stool samples or blood tests. Treatment typically involves the use of anti-parasitic drugs to kill the cestodes, and supportive care to manage symptoms and prevent complications.
Prevention measures include:
* Proper cooking and handling of food
* Avoiding consumption of undercooked meat, especially pork and beef
* Avoiding contact with animals that may be infected with cestodes
* Practicing good hygiene, such as washing hands regularly
* Keeping pets free of cestode infections to prevent human infection.
It is important to seek medical attention if symptoms persist or worsen over time, or if there are signs of complications such as inflammation or obstruction of the affected organ.
There are two main types of schistosomiasis:
1. Schistosoma haematobium: This type is most commonly found in Africa and the Middle East, and affects the urinary tract, causing bleeding, kidney damage, and bladder problems.
2. Schistosoma japonicum: This type is found in Asia, and affects the intestines, causing abdominal pain, diarrhea, and rectal bleeding.
3. Schistosoma mansoni: This type is found in sub-Saharan Africa, and affects both the intestines and the liver, causing abdominal pain, diarrhea, and liver damage.
Symptoms of schistosomiasis can include:
* Bloody urine
* Abdominal pain
* Diarrhea
* Rectal bleeding
* Fatigue
* Anemia
* Weight loss
If left untreated, schistosomiasis can lead to serious complications such as kidney damage, bladder cancer, and infertility.
Treatment of schistosomiasis typically involves the use of praziquantel, an antiparasitic drug that is effective against all species of Schistosoma. In addition to treatment, preventive measures such as avoiding contact with contaminated water and using protective clothing when swimming or bathing in areas where the disease is common can help reduce the risk of infection.
Preventive measures for schistosomiasis include:
* Avoiding contact with contaminated water
* Using protective clothing such as long sleeves and pants when swimming or bathing in areas where the disease is common
* Avoiding activities that involve exposure to water, such as swimming or fishing, in areas where the disease is common
* Using clean water for drinking, cooking, and personal hygiene
* Implementing sanitation measures such as building latrines and improving sewage systems in areas where the disease is common
It is important to note that schistosomiasis is a preventable and treatable disease, but it requires awareness and action from individuals, communities, and governments to control and eliminate the disease.
The infection occurs when the parasitic worm enters the body through the skin, usually during contact with infected water. The schistosomes migrate to the liver and intestines, where they cause inflammation and damage to the host tissues.
Symptoms of schistosomiasis mansoni can include abdominal pain, diarrhea, fatigue, and weight loss. If left untreated, it can lead to serious complications such as anemia, liver and kidney damage, and even death.
Diagnosis is based on the presence of schistosome eggs in the urine or stool, and treatment typically involves a combination of antiparasitic drugs and supportive care to manage symptoms. Prevention measures include avoiding contact with contaminated water and using snail-killing agents to reduce the number of intermediate hosts.
The most common types of trematode infections include:
1. Schistosomiasis: This is a parasitic disease caused by Schistosoma worms that affects over 200 million people worldwide, primarily in developing countries. It is spread through contact with contaminated freshwater snails.
2. Fascioliasis (also known as liver fluke): This is a parasitic disease caused by Fasciola worms that affects humans and various animals, including sheep, cattle, and pigs. It is spread through consumption of contaminated water or food.
3. Clonorchiasis: This is a parasitic disease caused by Clonorchis sinensis worms that affects humans in parts of Asia, particularly in China and Korea. It is spread through consumption of raw or undercooked fish.
4. Opisthorchiasis: This is a parasitic disease caused by Opisthorchis viverrini worms that affects humans in parts of Southeast Asia, particularly in Thailand and Laos. It is spread through consumption of raw or undercooked fish.
The symptoms of trematode infections vary depending on the type of parasite and the organs affected, but they can include:
* Abdominal pain
* Diarrhea
* Fatigue
* Weakness
* Loss of appetite
* Nausea and vomiting
* Jaundice (yellowing of the skin and eyes)
* Inflammation of the liver, lung, or other organs
Trematode infections can be diagnosed through various techniques, including:
1. Microscopic examination of stool samples for parasite eggs or larvae.
2. Serological tests such as ELISA or immunochromatography to detect antibodies against the parasite in the blood.
3. Imaging techniques such as ultrasound, CT scan, or MRI to visualize the parasites or their effects on organs.
4. Endoscopy to examine the digestive tract for parasites or inflammation.
Treatment of trematode infections depends on the type of parasite and the severity of the infection, but it often involves anti-parasitic drugs such as praziquantel, triclabendazole, or oxfendazole, which are effective against most trematodes. In severe cases, hospitalization may be required to manage complications such as liver inflammation or respiratory failure. Prevention measures include:
1. Avoiding consumption of raw or undercooked fish and other aquatic animals.
2. Properly cooking fish and other seafood before eating them.
3. Using clean water for drinking, cooking, and washing.
4. Avoiding contact with contaminated water or snails that may carry trematodes.
5. Implementing sanitation and hygiene measures in areas where trematode infections are common.
Trematodes are a diverse group of parasites that can infect humans and other animals, causing a range of diseases with varying severity. Diagnosis is based on serological or imaging techniques, and treatment involves anti-parasitic drugs. Prevention measures include avoiding raw or undercooked seafood, properly cooking fish and other seafood, using clean water, and implementing sanitation and hygiene measures in areas where trematode infections are common.
1. Malaria: A disease caused by a parasite that is transmitted through the bite of an infected mosquito. It can cause fever, chills, and flu-like symptoms.
2. Giardiasis: A disease caused by a parasite that is found in contaminated food and water. It can cause diarrhea, abdominal cramps, and weight loss.
3. Toxoplasmosis: A disease caused by a parasite that is transmitted through the consumption of contaminated meat or cat feces. It can cause fever, headache, and swollen lymph nodes.
4. Leishmaniasis: A group of diseases caused by a parasite that is transmitted through the bite of an infected sandfly. It can cause skin sores, fatigue, and weight loss.
5. Chagas disease: A disease caused by a parasite that is transmitted through the bite of an infected triatomine bug. It can cause heart problems, digestive issues, and brain damage.
6. Trichomoniasis: A disease caused by a parasite that is transmitted through sexual contact with an infected person. It can cause vaginal itching, burning during urination, and abnormal vaginal discharge.
7. Cryptosporidiosis: A disease caused by a parasite that is found in contaminated water and food. It can cause diarrhea, vomiting, and stomach cramps.
8. Amoebiasis: A disease caused by a parasite that is found in contaminated water and food. It can cause diarrhea, abdominal pain, and rectal bleeding.
9. Babesiosis: A disease caused by a parasite that is transmitted through the bite of an infected blacklegged tick. It can cause fever, chills, and fatigue.
10. Angiostrongyliasis: A disease caused by a parasite that is transmitted through the ingestion of raw or undercooked snails or slugs. It can cause eosinophilic meningitis, which is an inflammation of the membranes covering the brain and spinal cord.
It's important to note that these are just a few examples of parasitic diseases, and there are many more out there. Additionally, while some of these diseases can be treated with antiparasitic medications, others may require long-term management and supportive care. It's important to seek medical attention if you suspect that you have been infected with a parasite or if you experience any symptoms that could be related to a parasitic infection.
In the medical field, hymenolepiasis is often diagnosed using a combination of clinical evaluation, laboratory tests, and imaging studies such as X-rays or CT scans. Treatment typically involves the use of anthelmintic drugs to kill the tapeworms and relieve symptoms.
Preventive measures for hymenolepiasis include avoiding contaminated food and water, washing hands and fruits and vegetables thoroughly before eating them, and cooking food thoroughly especially pork and wild game meats.
The infection occurs when the larvae of the roundworm enter the body through the skin or mucous membranes, typically through contact with contaminated soil or water. Once inside the body, the larvae migrate to various organs and tissues, including the liver, lungs, and intestines, where they can cause a range of symptoms.
The symptoms of necatoriasis can vary depending on the location of the infection and the severity of the infestation. Common symptoms include:
* Skin lesions or rashes
* Respiratory problems, such as coughing and wheezing
* Abdominal pain and diarrhea
* Fever and chills
* Weakness and fatigue
If left untreated, necatoriasis can lead to serious complications, such as intestinal obstruction, anemia, and other infections. Treatment typically involves the use of anti-parasitic medications, such as albendazole or mebendazole, to kill the parasites and prevent further damage. In severe cases, hospitalization may be necessary to manage complications and supportive care.
Preventing necatoriasis involves measures to avoid contact with contaminated soil and water, such as using clean water for drinking and washing, wearing protective clothing when working or playing outdoors, and practicing good hygiene. In areas where the infection is common, regular deworming programs can also help to reduce the prevalence of necatoriasis.
The symptoms of strongyloidiasis can vary depending on the location and severity of the infection, but they typically include abdominal pain, diarrhea, fatigue, and weight loss. In severe cases, the parasite can migrate to other parts of the body, including the lungs, liver, and brain, causing a range of complications such as pneumonia, hepatitis, and meningitis.
Strongyloidiasis is diagnosed through a combination of physical examination, medical history, and laboratory tests such as stool samples or blood tests. Treatment typically involves antiparasitic medications, such as ivermectin or albendazole, which are effective in eliminating the parasite from the body. In severe cases, hospitalization may be necessary to manage complications and supportive care.
Preventive measures for strongyloidiasis include improving sanitation and hygiene practices, wearing protective clothing and footwear when working or living in areas with poor sanitation, and avoiding contact with contaminated soil or water. In endemic areas, mass drug administration programs can be effective in reducing the prevalence of strongyloidiasis and other neglected tropical diseases.
The symptoms of trichinellosis can vary depending on the severity of the infection and the number of parasites consumed. Mild cases may not exhibit any symptoms at all, while more severe cases can cause a range of symptoms including:
* Abdominal pain
* Diarrhea
* Fever
* Headache
* Muscle pain
* Skin rash
* Swelling of the face and eyelids
In severe cases, trichinellosis can lead to complications such as inflammation of the heart, brain, and liver, and can be fatal if left untreated.
Trichinellosis is diagnosed through a combination of physical examination, medical history, and laboratory tests such as blood tests or biopsies. Treatment typically involves antiparasitic drugs to kill the parasite, and supportive care to manage symptoms.
Prevention of trichinellosis primarily involves proper food handling and cooking practices, such as cooking meat to an internal temperature of at least 165°F (74°C) to kill any Trichinella parasites that may be present. Avoiding the consumption of raw or undercooked meat, particularly from wild game animals, can also help prevent the infection.
Coinfection can be caused by various factors, including:
1. Exposure to multiple pathogens: When an individual is exposed to multiple sources of infection, such as contaminated food or water, they may contract multiple pathogens simultaneously.
2. Weakened immune system: A compromised immune system can make it more difficult for the body to fight off infections, making it more susceptible to coinfection.
3. Increased opportunities for transmission: In some situations, such as in healthcare settings or during travel to areas with high infection rates, individuals may be more likely to come into contact with multiple pathogens.
Examples of common coinfections include:
1. HIV and tuberculosis (TB): TB is a common opportunistic infection that affects individuals with HIV/AIDS.
2. Malaria and bacterial infections: In areas where malaria is prevalent, individuals may also be at risk for bacterial infections such as pneumonia or diarrhea.
3. Influenza and Streptococcus pneumoniae: During flu season, individuals may be more susceptible to both influenza and bacterial infections such as pneumonia.
Coinfection can have significant consequences for an individual's health, including increased morbidity and mortality. Treatment of coinfections often requires a combination of antimicrobial therapies targeting each pathogen, as well as supportive care to manage symptoms and prevent complications.
Preventing coinfection is important for maintaining good health, especially in individuals with compromised immune systems. This can include:
1. Practicing good hygiene: Washing hands regularly and avoiding close contact with individuals who are sick can help reduce the risk of infection.
2. Getting vaccinated: Vaccines can protect against certain infections, such as influenza and pneumococcal disease.
3. Taking antimicrobial prophylaxis: In some cases, taking antibiotics or other antimicrobial drugs may be recommended to prevent infection in individuals who are at high risk of coinfection.
4. Managing underlying conditions: Effectively managing conditions such as HIV/AIDS, diabetes, and heart disease can help reduce the risk of infection and coinfection.
5. Avoiding risky behaviors: Avoiding risky behaviors such as sharing needles or engaging in unprotected sex can help reduce the risk of infection and coinfection.
The infection occurs when a person ingests undercooked or raw meat containing the tapeworm larvae, which then migrate to the intestines and mature into adult worms. The adult tapeworms can live for up to 20 years in the host's intestine, causing no symptoms in some cases, while in others, they may cause abdominal pain, diarrhea, and weight loss.
If left untreated, taeniasis can lead to complications such as intestinal blockages, perforation of the intestines, and anemia due to blood loss. Treatment typically involves anti-parasitic drugs to kill the adult worms and larvae. Prevention measures include proper cooking of meat, especially beef, to an internal temperature of at least 160°F (71°C) for a few minutes, as well as good hygiene practices when handling raw meat.
Symptoms of fascioliasis can vary depending on the severity of the infection and may include:
1. Abdominal pain
2. Diarrhea
3. Vomiting
4. Fatigue
5. Weight loss
6. Anemia
7. Elevated liver enzymes
8. Inflammation of the liver, bile ducts, or pancreas
If left untreated, fascioliasis can lead to serious complications such as:
1. Cholangiohepatitis (inflammation of the bile ducts and liver)
2. Hepatic cysts or cirrhosis (scarring of the liver)
3. Biliary obstruction or pancreatitis (inflammation of the pancreas)
Diagnosis of fascioliasis typically involves a combination of physical examination, medical history, and laboratory tests such as:
1. Blood tests to detect antibodies against the parasite
2. Detection of the parasite in stool or bile samples
3. Imaging studies such as ultrasound or CT scans to visualize the liver and bile ducts
Treatment of fascioliasis usually involves the use of antiparasitic drugs, such as triclabendazole or nitazoxanide, to eliminate the parasite from the body. Supportive care may also be provided to manage symptoms and prevent complications.
Prevention of fascioliasis primarily involves measures to avoid ingesting contaminated food or water, such as:
1. Avoiding consumption of raw or undercooked meat, particularly pork or lamb
2. Properly cooking and storing food
3. Avoiding consumption of untreated water
4. Using proper sanitation and hygiene practices
5. Avoiding contact with contaminated soil or water
In areas where fascioliasis is common, it is important to be aware of the risk and take appropriate precautions to prevent infection. Early detection and treatment can help prevent complications and improve outcomes for patients with fascioliasis.
The symptoms of toxocariasis can vary depending on the location of the parasite in the body, but they may include:
* Eye problems, such as blurred vision, eye pain, and inflammation of the retina
* Skin rashes or lesions
* Joint pain and swelling
* Neurological symptoms, such as headaches, seizures, and loss of coordination
* Diarrhea and abdominal pain
Toxocariasis is diagnosed through a combination of physical examination, medical history, and laboratory tests, such as blood tests and imaging studies. Treatment typically involves antiparasitic medications, which can help to eliminate the parasites from the body. In severe cases, hospitalization may be necessary to manage complications such as eye inflammation or neurological problems.
Preventive measures for toxocariasis include:
* Avoiding contact with contaminated soil or feces
* Washing hands and food thoroughly
* Keeping pets free of parasites through regular deworming and proper sanitation
* Avoiding eating undercooked meat, especially pork and wild game
While toxocariasis is generally not life-threatening, it can cause significant morbidity and vision loss if left untreated. Therefore, it is important to seek medical attention if symptoms persist or worsen over time.
Symptoms of mansonelliasis include fever, headache, joint pain, skin rashes, and swelling of the liver and spleen. These symptoms can be non-specific and may resemble those of other diseases, making diagnosis challenging.
The diagnosis of mansonelliasis is based on a combination of clinical findings, laboratory tests (such as blood smears and polymerase chain reaction), and the presence of characteristic skin lesions. Treatment of mansonelliasis typically involves the use of antiparasitic drugs such as diethylcarbamazine (DEC) and albendazole.
Preventive measures for mansonelliasis include using insecticides to control sandfly populations, wearing protective clothing and applying insect repellents when outdoors in areas where the parasites are common, and taking antiparasitic medications to prevent infection.
The clinical manifestations of echinostomiasis are varied and can include hematuria, dysuria, urinary frequency, flank pain, and bladder mass lesions. The diagnosis is based on the presence of characteristic eggs in urine or stool samples, or on the detection of adult worms during cystoscopy or imaging studies such as ultrasound or computed tomography (CT) scan.
Treatment of echinostomiasis typically involves the use of antiparasitic drugs, such as praziquantel or triclabendazole, which are effective in killing the adult worms and preventing further egg production. Surgical intervention may be necessary in cases with large bladder stones or hydronephrosis.
Preventive measures against echinostomiasis include education on safe water drinking practices, use of clean water for irrigation and cooking, and avoidance of raw or undercooked fish consumption.
In conclusion, echinostomiasis is a rare and neglected parasitic infection that can cause significant morbidity and mortality in certain regions of the world. Early diagnosis and treatment are essential to prevent complications and reduce the risk of transmission.
Schistosomiasis haematobia is a parasitic disease caused by the blood fluke worm Schistosoma haematobium. It is one of the two main types of schistosomiasis, with the other being schistosomiasis mansoni. The disease is most commonly found in Africa and the Middle East, where it affects millions of people each year.
The symptoms of schistosomiasis haematobia can vary depending on the severity of the infection and the location of the parasites in the body. Some common symptoms include:
* Blood in the urine
* Abdominal pain
* Diarrhea
* Vaginal bleeding in women
* Rectal bleeding in men
* Weakness and fatigue
* Fever
If left untreated, schistosomiasis haematobia can lead to complications such as kidney damage, bladder cancer, and infertility. In severe cases, it can be fatal.
The diagnosis of schistosomiasis haematobia is typically made through a combination of physical examination, medical history, and laboratory tests such as blood tests or urine tests. Treatment typically involves the use of praziquantel, a drug that is effective against all species of Schistosoma worms.
Prevention measures for schistosomiasis haematobia include avoiding contact with contaminated water and using appropriate sanitation and hygiene practices, such as washing hands after using the bathroom or before handling food. In areas where the disease is common, snail control measures can also be effective in reducing the risk of infection.
Overall, schistosomiasis haematobia is a serious and debilitating disease that can have severe consequences if left untreated. It is important to take preventive measures to avoid infection and to seek medical attention if symptoms persist or worsen over time.
1. Heartworms: A parasite that infects the heart and lungs of dogs and cats, causing respiratory problems and potentially leading to heart failure.
2. Tapeworms: A type of parasite that can infect the digestive system of animals, causing weight loss, diarrhea, and other symptoms.
3. Mites: Small, eight-legged parasites that can cause skin irritation and allergic reactions in animals.
4. Lice: Small, wingless parasites that feed on the blood of animals, causing itching and scratching.
5. Hookworms: A type of parasite that can infect the digestive system of animals, causing weight loss, anemia, and other symptoms.
6. Roundworms: A common type of parasite that can infect animals, causing a range of symptoms including diarrhea, vomiting, and weight loss.
7. Ticks: Blood-sucking parasites that can transmit diseases to animals, such as Lyme disease and anaplasmosis.
8. Fleas: Small, wingless insects that feed on the blood of animals, causing itching and scratching.
9. Leishmaniasis: A parasitic disease caused by a protozoan parasite that can infect dogs and other animals, causing skin lesions and other symptoms.
10. Babesiosis: A parasitic disease caused by a protozoan parasite that can infect dogs and other animals, causing fever, anemia, and other symptoms.
Parasitic diseases in animals are often diagnosed through physical examination, laboratory tests, and imaging studies. Treatment options vary depending on the specific disease and the severity of the infection, but may include antiparasitic medications, antibiotics, and supportive care such as fluid therapy and nutritional support. Prevention is key in avoiding parasitic diseases in animals, and this can be achieved through regular deworming and vaccination programs, as well as taking measures to reduce exposure to parasites such as fleas and ticks.
Examples of pregnancy complications, parasitic include:
1. Toxoplasmosis: This is a condition caused by the Toxoplasma gondii parasite, which can infect the mother and/or the fetus during pregnancy. Symptoms include fever, headache, and fatigue. In severe cases, toxoplasmosis can cause birth defects, such as intellectual disability, blindness, and deafness.
2. Malaria: This is a condition caused by the Plasmodium spp. parasite, which can be transmitted to the mother and/or the fetus during pregnancy. Symptoms include fever, chills, and flu-like symptoms. In severe cases, malaria can cause anemia, organ failure, and death.
3. Schistosomiasis: This is a condition caused by the Schistosoma spp. parasite, which can infect the mother and/or the fetus during pregnancy. Symptoms include abdominal pain, diarrhea, and fatigue. In severe cases, schistosomiasis can cause organ damage and infertility.
Pregnancy complications, parasitic can be diagnosed through blood tests, imaging studies, and other medical procedures. Treatment depends on the type of parasite and the severity of the infection. In some cases, treatment may involve antibiotics, antimalarial drugs, or anti-parasitic medications.
Preventive measures for pregnancy complications, parasitic include:
1. Avoiding contact with cat feces, as Toxoplasma gondii can be transmitted through contaminated soil and food.
2. Avoiding travel to areas where malaria and other parasitic infections are common.
3. Taking antimalarial medications before and during pregnancy if living in an area where malaria is common.
4. Using insecticide-treated bed nets and wearing protective clothing to prevent mosquito bites.
5. Practicing good hygiene, such as washing hands regularly, especially after handling food or coming into contact with cats.
6. Avoiding drinking unpasteurized dairy products and undercooked meat, as these can increase the risk of infection.
7. Ensuring that any water used for cooking or drinking is safe and free from parasites.
Preventive measures for pregnancy complications, parasitic are important for women who are pregnant or planning to become pregnant, as well as for their partners and healthcare providers. By taking these preventive measures, the risk of infection and complications can be significantly reduced.
In conclusion, pregnancy complications, parasitic are a serious issue that can have severe consequences for both the mother and the fetus. However, by understanding the causes, risk factors, symptoms, diagnosis, treatment, and preventive measures, women can take steps to protect themselves and their unborn babies from these infections. It is important for healthcare providers to be aware of these issues and provide appropriate education and care to pregnant women to reduce the risk of complications.
FAQs
1. What are some common parasitic infections that can occur during pregnancy?
Ans: Some common parasitic infections that can occur during pregnancy include malaria, toxoplasmosis, and cytomegalovirus (CMV).
2. How do parasitic infections during pregnancy affect the baby?
Ans: Parasitic infections during pregnancy can have serious consequences for the developing fetus, including birth defects, growth restriction, and stillbirth.
3. Can parasitic infections during pregnancy be treated?
Ans: Yes, parasitic infections during pregnancy can be treated with antibiotics and other medications. Early detection and treatment are important to prevent complications.
4. How can I prevent parasitic infections during pregnancy?
Ans: Preventive measures include avoiding areas where parasites are common, using insect repellents, wearing protective clothing, and practicing good hygiene. Pregnant women should also avoid undercooked meat and unpasteurized dairy products.
5. Do all pregnant women need to be tested for parasitic infections?
Ans: No, not all pregnant women need to be tested for parasitic infections. However, certain groups of women, such as those who live in areas where parasites are common or have a history of previous parasitic infections, may need to be tested and monitored more closely.
6. Can I prevent my baby from getting a parasitic infection during pregnancy?
Ans: Yes, there are several steps you can take to reduce the risk of your baby getting a parasitic infection during pregnancy, such as avoiding certain foods and taking antibiotics if necessary. Your healthcare provider can provide guidance on how to prevent and treat parasitic infections during pregnancy.
7. How are parasitic infections diagnosed during pregnancy?
Ans: Parasitic infections can be diagnosed through blood tests, stool samples, or imaging tests such as ultrasound or MRI. Your healthcare provider may also perform a physical exam and take a medical history to determine the likelihood of a parasitic infection.
8. Can parasitic infections cause long-term health problems for my baby?
Ans: Yes, some parasitic infections can cause long-term health problems for your baby, such as developmental delays or learning disabilities. In rare cases, parasitic infections can also lead to more serious complications, such as organ damage or death.
9. How are parasitic infections treated during pregnancy?
Ans: Treatment for parasitic infections during pregnancy may involve antibiotics, antiparasitic medications, or other supportive care. Your healthcare provider will determine the best course of treatment based on the severity and type of infection, as well as your individual circumstances.
10. Can I take steps to prevent parasitic infections during pregnancy?
Ans: Yes, there are several steps you can take to prevent parasitic infections during pregnancy, such as avoiding undercooked meat and fish, washing fruits and vegetables thoroughly, and practicing good hygiene. Additionally, if you have a higher risk of parasitic infections due to travel or other factors, your healthcare provider may recommend preventative medications or screening tests.
11. I'm pregnant and have been exposed to a parasitic infection. What should I do?
Ans: If you suspect that you have been exposed to a parasitic infection during pregnancy, it is important to seek medical attention immediately. Your healthcare provider can perform tests to determine if you have an infection and provide appropriate treatment to prevent any potential complications for your baby.
12. Can I breastfeed while taking medication for a parasitic infection?
Ans: It may be safe to breastfeed while taking medication for a parasitic infection, but it is important to consult with your healthcare provider before doing so. Some medications may not be safe for your baby and could potentially be passed through your milk. Your healthcare provider can provide guidance on the safest treatment options for you and your baby.
13. What are some common complications of parasitic infections during pregnancy?
Ans: Complications of parasitic infections during pregnancy can include miscarriage, preterm labor, low birth weight, and congenital anomalies. In rare cases, parasitic infections can also be transmitted to the baby during pregnancy or childbirth, which can lead to serious health problems for the baby.
14. Can I get a parasitic infection from my pet?
Ans: Yes, it is possible to get a parasitic infection from your pet if you come into contact with their feces or other bodily fluids. For example, toxoplasmosis can be transmitted through contact with cat feces, while hookworm infections can be spread through contact with contaminated soil or feces. It is important to practice good hygiene and take precautions when handling pets or coming into contact with potentially contaminated areas.
15. How can I prevent parasitic infections?
Ans: Preventing parasitic infections involves taking steps to avoid exposure to parasites and their vectors, as well as practicing good hygiene and taking precautions when traveling or engaging in activities that may put you at risk. Some ways to prevent parasitic infections include:
* Avoiding undercooked meat, especially pork and wild game
* Avoiding raw or unpasteurized dairy products
* Avoiding contaminated water and food
* Washing your hands frequently, especially after using the bathroom or before handling food
* Avoiding contact with cat feces, as toxoplasmosis can be transmitted through contact with cat feces
* Using protective clothing and insect repellent when outdoors in areas where parasites are common
* Keeping your home clean and free of clutter to reduce the risk of parasite infestations
* Avoiding touching or eating wild animals or plants that may be contaminated with parasites
16. What are some common misconceptions about parasitic infections?
Ans: There are several common misconceptions about parasitic infections, including:
* All parasites are the same and have similar symptoms
* Parasitic infections are only a problem for people who live in developing countries or have poor hygiene
* Only certain groups of people, such as children or pregnant women, are at risk for parasitic infections
* Parasitic infections are rare in developed countries
* All parasites can be treated with antibiotics
* Parasitic infections are not serious and do not require medical attention
17. How can I diagnose a parasitic infection?
Ans: Diagnosing a parasitic infection typically involves a combination of physical examination, medical history, and laboratory tests. Some common methods for diagnosing parasitic infections include:
* Physical examination to look for signs such as skin lesions or abdominal pain
* Blood tests to check for the presence of parasites or their waste products
* Stool tests to detect the presence of parasite eggs or larvae
* Imaging tests, such as X-rays or CT scans, to look for signs of parasite infection in internal organs
* Endoscopy, which involves inserting a flexible tube with a camera into the body to visualize the inside of the digestive tract and other organs.
18. How are parasitic infections treated?
Ans: Treatment for parasitic infections depends on the type of parasite and the severity of the infection. Some common methods for treating parasitic infections include:
* Antiparasitic drugs, such as antibiotics or antimalarials, to kill the parasites
* Supportive care, such as fluids and electrolytes, to manage symptoms and prevent complications
* Surgery to remove parasites or repair damaged tissues
* Antibiotics to treat secondary bacterial infections that may have developed as a result of the parasitic infection.
It is important to seek medical attention if you suspect that you have a parasitic infection, as untreated infections can lead to serious complications and can be difficult to diagnose.
19. How can I prevent parasitic infections?
Ans: Preventing parasitic infections involves taking steps to avoid contact with parasites and their vectors, as well as maintaining good hygiene practices. Some ways to prevent parasitic infections include:
* Avoiding undercooked meat and unpasteurized dairy products, which can contain harmful parasites such as Trichinella spiralis and Toxoplasma gondii
* Washing your hands frequently, especially after using the bathroom or before eating
* Avoiding contact with contaminated water or soil, which can harbor parasites such as Giardia and Cryptosporidium
* Using insecticides and repellents to prevent mosquito bites, which can transmit diseases such as malaria and dengue fever
* Wearing protective clothing and applying insect repellent when outdoors in areas where ticks and other vectors are common
* Avoiding contact with animals that may carry parasites, such as dogs and cats that can transmit Toxoplasma gondii
* Using clean water and proper sanitation to prevent the spread of parasitic infections in communities and developing countries.
It is also important to be aware of the risks of parasitic infections when traveling to areas where they are common, and to take appropriate precautions such as avoiding undercooked meat and unpasteurized dairy products, and using insecticides and repellents to prevent mosquito bites.
20. What is the prognosis for parasitic infections?
Ans: The prognosis for parasitic infections varies depending on the specific type of infection and the severity of symptoms. Some parasitic infections can be easily treated with antiparasitic medications, while others may require more extensive treatment and management.
In general, the prognosis for parasitic infections is good if the infection is detected early and properly treated. However, some parasitic infections can cause long-term health problems or death if left untreated. It is important to seek medical attention if symptoms persist or worsen over time.
It is also important to note that some parasitic infections can be prevented through public health measures such as using clean water and proper sanitation, and controlling the spread of insect vectors. Prevention is key to avoiding the negative outcomes associated with these types of infections.
21. What are some common complications of parasitic infections?
Ans: Some common complications of parasitic infections include:
* Anemia and other blood disorders, such as thrombocytopenia and leukopenia
* Allergic reactions to parasite antigens
* Inflammation and damage to organs and tissues, such as the liver, kidneys, and brain
* Increased risk of infections with other microorganisms, such as bacteria and viruses
* Malnutrition and deficiencies in essential nutrients
* Organ failure and death.
22. Can parasitic infections be prevented? If so, how?
Ans: Yes, some parasitic infections can be prevented through public health measures such as:
* Using clean water and proper sanitation to reduce the risk of ingesting infected parasites.
* Avoiding contact with insect vectors, such as mosquitoes and ticks, by using repellents, wearing protective clothing, and staying indoors during peak biting hours.
* Properly cooking and storing food to kill parasites that may be present.
* Avoiding consuming undercooked or raw meat, especially pork and wild game.
* Practicing safe sex to prevent the transmission of parasitic infections through sexual contact.
* Keeping children away from areas where they may come into contact with contaminated soil or water.
* Using antiparasitic drugs and other treatments as recommended by healthcare providers.
* Implementing control measures for insect vectors, such as spraying insecticides and removing breeding sites.
30. Can parasitic infections be treated with antibiotics? If so, which ones and why?
Ans: No, antibiotics are not effective against parasitic infections caused by protozoa, such as giardiasis and amoebiasis, because these organisms are not bacteria. However, antibiotics may be used to treat secondary bacterial infections that can develop as a complication of parasitic infections.
32. What is the difference between a parasite and a pathogen?
Ans: A parasite is an organism that lives on or in another organism, called the host, and feeds on the host's tissues or fluids without providing any benefits. A pathogen, on the other hand, is an organism that causes disease. While all parasites are pathogens, not all pathogens are parasites. For example, bacteria and viruses can cause diseases but are not considered parasites because they do not live within the host's body.
The term "systemic" refers to the fact that the disease affects multiple organ systems, including the skin, joints, kidneys, lungs, and nervous system. LES is a complex condition, and its symptoms can vary widely depending on which organs are affected. Common symptoms include fatigue, fever, joint pain, rashes, and swelling in the extremities.
There are several subtypes of LES, including:
1. Systemic lupus erythematosus (SLE): This is the most common form of the disease, and it can affect anyone, regardless of age or gender.
2. Discoid lupus erythematosus (DLE): This subtype typically affects the skin, causing a red, scaly rash that does not go away.
3. Drug-induced lupus erythematosus: This form of the disease is caused by certain medications, and it usually resolves once the medication is stopped.
4. Neonatal lupus erythematosus: This rare condition affects newborn babies of mothers with SLE, and it can cause liver and heart problems.
There is no cure for LES, but treatment options are available to manage the symptoms and prevent flares. Treatment may include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressive medications, and antimalarial drugs. In severe cases, hospitalization may be necessary to monitor and treat the disease.
It is important for people with LES to work closely with their healthcare providers to manage their condition and prevent complications. With proper treatment and self-care, many people with LES can lead active and fulfilling lives.
1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.
2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.
3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.
4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.
5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.
6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.
7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.
8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.
9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.
10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.
Examples of neglected diseases include:
1. Dengue fever: A mosquito-borne viral disease that affects millions of people worldwide, particularly in urban slums and other areas with poor sanitation and hygiene.
2. Chagas disease: A parasitic disease caused by the Trypanosoma cruzi parasite, which is transmitted through the bite of an infected triatomine bug. It affects millions of people in Latin America and can cause serious heart and gastrointestinal complications.
3. Leishmaniasis: A parasitic disease caused by several species of the Leishmania parasite, which is transmitted through the bite of an infected sandfly. It affects millions of people worldwide, particularly in Africa, Asia, and Latin America.
4. Onchocerciasis (river blindness): A parasitic disease caused by the Onchocerca volvulus parasite, which is transmitted through the bite of an infected blackfly. It affects millions of people in Africa and can cause blindness, skin lesions, and other serious complications.
5. Schistosomiasis: A parasitic disease caused by the Schistosoma parasite, which is transmitted through contact with contaminated water. It affects hundreds of millions of people worldwide, particularly in sub-Saharan Africa and Latin America.
6. Lymphatic filariasis: A parasitic disease caused by the Wuchereria bancrofti, Brugia malayi, and Loa loa parasites, which are transmitted through the bite of an infected mosquito. It affects millions of people worldwide, particularly in Africa and Asia, and can cause severe swelling of the limbs and other serious complications.
7. Chagas disease: A parasitic disease caused by the Trypanosoma cruzi parasite, which is transmitted through the bite of an infected triatomine bug. It affects millions of people in Latin America and can cause heart failure, digestive problems, and other serious complications.
These diseases are often chronic and debilitating, and can have a significant impact on the quality of life of those affected. In addition to the physical symptoms, they can also cause social and economic burdens, such as lost productivity and reduced income.
In terms of public health, these diseases pose a significant challenge for healthcare systems, particularly in developing countries where resources may be limited. They require sustained efforts to control and eliminate, including disease surveillance, vector control, and treatment.
In addition, these diseases are often interconnected with other health issues, such as poverty, poor sanitation, and lack of access to healthcare. Therefore, addressing these diseases requires a comprehensive approach that takes into account the social and economic factors that contribute to their spread.
Overall, the impact of these diseases on public health is significant, and sustained efforts are needed to control and eliminate them.
There are several types of hypersensitivity reactions, including:
1. Type I hypersensitivity: This is also known as immediate hypersensitivity and occurs within minutes to hours after exposure to the allergen. It is characterized by the release of histamine and other chemical mediators from immune cells, leading to symptoms such as hives, itching, swelling, and difficulty breathing. Examples of Type I hypersensitivity reactions include allergies to pollen, dust mites, or certain foods.
2. Type II hypersensitivity: This is also known as cytotoxic hypersensitivity and occurs within days to weeks after exposure to the allergen. It is characterized by the immune system producing antibodies against specific proteins on the surface of cells, leading to their destruction. Examples of Type II hypersensitivity reactions include blood transfusion reactions and serum sickness.
3. Type III hypersensitivity: This is also known as immune complex hypersensitivity and occurs when antigens bind to immune complexes, leading to the formation of deposits in tissues. Examples of Type III hypersensitivity reactions include rheumatoid arthritis and systemic lupus erythematosus.
4. Type IV hypersensitivity: This is also known as delayed-type hypersensitivity and occurs within weeks to months after exposure to the allergen. It is characterized by the activation of T cells, leading to inflammation and tissue damage. Examples of Type IV hypersensitivity reactions include contact dermatitis and toxic epidermal necrolysis.
The diagnosis of hypersensitivity often involves a combination of medical history, physical examination, laboratory tests, and elimination diets or challenges. Treatment depends on the specific type of hypersensitivity reaction and may include avoidance of the allergen, medications such as antihistamines or corticosteroids, and immunomodulatory therapy.
Symptoms of filarial elephantiasis include swelling and thickening of the skin, especially in the legs, feet, and hands, as well as a loss of sensation in the affected areas. Treatment typically involves the use of antiparasitic drugs to kill the worms, but surgery may be necessary in some cases to remove severely affected tissue.
Preventive measures include avoiding mosquito bites by using insect repellents and wearing protective clothing, as well as taking antiparasitic medications to prevent infection. Early diagnosis and treatment can help prevent the development of severe complications and improve quality of life for individuals with filarial elephantiasis.
Previous Article What is the purpose of a 'deed of trust'? Next Article What are some common types of 'disorders' that can affect the human body?
The symptoms of ancylostomiasis can vary depending on the severity of the infection, but they typically include abdominal pain, diarrhea, fatigue, weight loss, and iron deficiency anemia. In severe cases, it can lead to life-threatening complications such as intestinal blockage or bleeding.
The diagnosis of ancylostomiasis is made by identifying the parasites in a stool sample or through blood tests that detect antigens produced by the parasites. Treatment typically involves the use of anthelmintic drugs to kill the parasites, and supportive care to manage symptoms such as diarrhea and anemia. Prevention measures include improving sanitation and personal hygiene, and avoiding contact with contaminated soil or feces.
The disease is transmitted through the bite of an infected blackfly of the genus Simulium. The parasitic worm Onchocerca volvulus is deposited into the skin of the human host, where it forms nodules that can migrate to various parts of the body, including the eye and skin.
The symptoms of onchocerciasis can vary depending on the location and severity of the infection. Skin symptoms include a rash, papules, and nodules, while eye symptoms can include vision loss, blurred vision, and blindness. The disease can also cause joint pain and fever.
Onchocerciasis is diagnosed through a combination of physical examination, medical history, and laboratory tests, such as skin biopsy or blood testing for antigens. Treatment involves administering the drug ivermectin, which kills the adult worms and reduces symptoms. However, the drug does not kill the microfilariae, which can continue to cause disease for years after treatment.
Prevention of onchocerciasis involves controlling the population of blackflies that transmit the disease. This is achieved through measures such as using insecticides, wearing protective clothing and applying repellents, and draining standing water where blackflies breed. Elimination of the disease requires mass drug administration to all individuals in endemic areas, followed by repeated treatment every 6-12 months for at least 10-15 years.
1. Hantavirus pulmonary syndrome (HPS): This is a severe respiratory disease caused by the hantavirus, which is found in the urine and saliva of infected rodents. Symptoms of HPS can include fever, headache, muscle pain, and difficulty breathing.
2. Leptospirosis: This is a bacterial infection caused by the bacterium Leptospira, which is found in the urine of infected rodents. Symptoms can include fever, headache, muscle pain, and jaundice (yellowing of the skin and eyes).
3. Rat-bite fever: This is a bacterial infection caused by the bacterium Streptobacillus moniliformis, which is found in the saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
4. Lymphocytic choriomeningitis (LCM): This is a viral infection caused by the lymphocytic choriomeningitis virus (LCMV), which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and meningitis (inflammation of the membranes surrounding the brain and spinal cord).
5. Tularemia: This is a bacterial infection caused by the bacterium Francisella tularensis, which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
These are just a few examples of the many diseases that can be transmitted to humans through contact with rodents. It is important to take precautions when handling or removing rodents, as they can pose a serious health risk. If you suspect that you have been exposed to a rodent-borne disease, it is important to seek medical attention as soon as possible.
Examples of autoimmune diseases include:
1. Rheumatoid arthritis (RA): A condition where the immune system attacks the joints, leading to inflammation, pain, and joint damage.
2. Lupus: A condition where the immune system attacks various body parts, including the skin, joints, and organs.
3. Hashimoto's thyroiditis: A condition where the immune system attacks the thyroid gland, leading to hypothyroidism.
4. Multiple sclerosis (MS): A condition where the immune system attacks the protective covering of nerve fibers in the central nervous system, leading to communication problems between the brain and the rest of the body.
5. Type 1 diabetes: A condition where the immune system attacks the insulin-producing cells in the pancreas, leading to high blood sugar levels.
6. Guillain-Barré syndrome: A condition where the immune system attacks the nerves, leading to muscle weakness and paralysis.
7. Psoriasis: A condition where the immune system attacks the skin, leading to red, scaly patches.
8. Crohn's disease and ulcerative colitis: Conditions where the immune system attacks the digestive tract, leading to inflammation and damage to the gut.
9. Sjögren's syndrome: A condition where the immune system attacks the glands that produce tears and saliva, leading to dry eyes and mouth.
10. Vasculitis: A condition where the immune system attacks the blood vessels, leading to inflammation and damage to the blood vessels.
The symptoms of autoimmune diseases vary depending on the specific disease and the organs or tissues affected. Common symptoms include fatigue, fever, joint pain, skin rashes, and swollen lymph nodes. Treatment for autoimmune diseases typically involves medication to suppress the immune system and reduce inflammation, as well as lifestyle changes such as dietary changes and stress management techniques.
There are several different types of malaria, including:
1. Plasmodium falciparum: This is the most severe form of malaria, and it can be fatal if left untreated. It is found in many parts of the world, including Africa, Asia, and Latin America.
2. Plasmodium vivax: This type of malaria is less severe than P. falciparum, but it can still cause serious complications if left untreated. It is found in many parts of the world, including Africa, Asia, and Latin America.
3. Plasmodium ovale: This type of malaria is similar to P. vivax, but it can cause more severe symptoms in some people. It is found primarily in West Africa.
4. Plasmodium malariae: This type of malaria is less common than the other three types, and it tends to cause milder symptoms. It is found primarily in parts of Africa and Asia.
The symptoms of malaria can vary depending on the type of parasite that is causing the infection, but they typically include:
1. Fever
2. Chills
3. Headache
4. Muscle and joint pain
5. Fatigue
6. Nausea and vomiting
7. Diarrhea
8. Anemia (low red blood cell count)
If malaria is not treated promptly, it can lead to more severe complications, such as:
1. Seizures
2. Coma
3. Respiratory failure
4. Kidney failure
5. Liver failure
6. Anemia (low red blood cell count)
Malaria is typically diagnosed through a combination of physical examination, medical history, and laboratory tests, such as blood smears or polymerase chain reaction (PCR) tests. Treatment for malaria typically involves the use of antimalarial drugs, such as chloroquine or artemisinin-based combination therapies. In severe cases, hospitalization may be necessary to manage complications and provide supportive care.
Prevention is an important aspect of managing malaria, and this can include:
1. Using insecticide-treated bed nets
2. Wearing protective clothing and applying insect repellent when outdoors
3. Eliminating standing water around homes and communities to reduce the number of mosquito breeding sites
4. Using indoor residual spraying (IRS) or insecticide-treated wall lining to kill mosquitoes
5. Implementing malaria control measures in areas where malaria is common, such as distribution of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS)
6. Improving access to healthcare services, particularly in rural and remote areas
7. Providing education and awareness about malaria prevention and control
8. Encouraging the use of preventive medications, such as intermittent preventive treatment (IPT) for pregnant women and children under the age of five.
Early diagnosis and prompt treatment are critical in preventing the progression of malaria and reducing the risk of complications and death. In areas where malaria is common, it is essential to have access to reliable diagnostic tools and effective antimalarial drugs.
1. Irritable Bowel Syndrome (IBS): A chronic condition characterized by abdominal pain, bloating, and changes in bowel habits.
2. Inflammatory Bowel Disease (IBD): A group of chronic conditions that cause inflammation in the digestive tract, including Crohn's disease and ulcerative colitis.
3. Diverticulosis: A condition in which small pouches form in the wall of the intestine, often causing abdominal pain and changes in bowel habits.
4. Intestinal obstruction: A blockage that prevents food, fluids, and gas from passing through the intestine, often causing abdominal pain, nausea, and vomiting.
5. Intestinal ischemia: A reduction in blood flow to the intestine, which can cause damage to the tissues and lead to life-threatening complications.
6. Intestinal cancer: Cancer that develops in the small intestine or large intestine, often causing symptoms such as abdominal pain, weight loss, and rectal bleeding.
7. Gastrointestinal infections: Infections caused by viruses, bacteria, or parasites that affect the gastrointestinal tract, often causing symptoms such as diarrhea, vomiting, and abdominal pain.
8. Intestinal motility disorders: Disorders that affect the movement of food through the intestine, often causing symptoms such as abdominal pain, bloating, and constipation.
9. Malabsorption: A condition in which the body is unable to properly absorb nutrients from food, often caused by conditions such as celiac disease or pancreatic insufficiency.
10. Intestinal pseudo-obstruction: A condition in which the intestine becomes narrowed or blocked, often causing symptoms such as abdominal pain, bloating, and constipation.
These are just a few examples of the many potential complications that can occur when the gastrointestinal system is not functioning properly. It is important to seek medical attention if you experience any persistent or severe symptoms in order to receive proper diagnosis and treatment.
Causes:
There are many possible causes of eosinophilia, including:
* Allergies
* Parasitic infections
* Autoimmune disorders
* Cancer
* Medications
Symptoms:
The symptoms of eosinophilia can vary depending on the underlying cause, but may include:
* Swelling of the skin, lips, and eyes
* Hives or itchy skin
* Shortness of breath or wheezing
* Abdominal pain
* Diarrhea
Diagnosis:
Eosinophilia is typically diagnosed through a blood test that measures the number of eosinophils in the blood. Other tests such as imaging studies, skin scrapings, and biopsies may also be used to confirm the diagnosis and identify the underlying cause.
Treatment:
The treatment of eosinophilia depends on the underlying cause, but may include medications such as antihistamines, corticosteroids, and chemotherapy. In some cases, removal of the causative agent or immunomodulatory therapy may be necessary.
Complications:
Eosinophilia can lead to a number of complications, including:
* Anaphylaxis (a severe allergic reaction)
* Asthma
* Eosinophilic granulomas (collections of eosinophils that can cause organ damage)
* Eosinophilic gastrointestinal disorders (conditions where eosinophils invade the digestive tract)
Prognosis:
The prognosis for eosinophilia depends on the underlying cause, but in general, the condition is not life-threatening. However, if left untreated, complications can arise and the condition can have a significant impact on quality of life.
In conclusion, eosinophilia is a condition characterized by an abnormal increase in eosinophils in the body. While it can be caused by a variety of factors, including allergies, infections, and autoimmune disorders, the underlying cause must be identified and treated in order to effectively manage the condition and prevent complications.
The word "haemon" comes from the Greek word for blood, and "chiasis" means a change or alteration in the normal condition of the body. So, haemonchosis literally means a change or alteration in the body caused by bleeding.
Bridget Ogilvie
Helminth protein
Immunoglobulin E
Isotype (immunology)
Schistosomiasis
Moses Rugut
Antibody-dependent cellular cytotoxicity
Antibody
Antigen-antibody interaction
Golden jackal
Kipsigis people
Fc receptor
Tropical eosinophilia
Basophil
Helminthiasis
List of MeSH codes (D12.776.124)
Chorioallantoic membrane
T helper cell
Loa loa filariasis
Ostertagia ostertagi
List of MeSH codes (D12.776)
Richard D. Cummings
Common buzzard
Immunology
Hookworm infection
Ascaris suum
Lymphatic filariasis
Peptide vaccine
Trichobilharzia regenti
Adaptive immune system
Food and biological process engineering
Interleukin 25
Pattern recognition receptor
Index of biochemistry articles
Food allergy
Heligmosomoides polygyrus
Hugo Sigman
Atopic dermatitis
Interleukin 13
Infection
Schistosoma haematobium
Transverse myelitis
Crohn's disease
Neorickettsia risticii
Reverse zoonosis
Schistosoma intercalatum
Parasitism
Eosinophilia
Studies on the helminth fauna of Alaska. XXIV. Echinococcus sibiricensis n. sp., from St. Lawrence Island - PubMed
Helminths, Soil-Transmitted | CDC Yellow Book 2024
Exposure to lung-migrating helminth protects against murine SARS-CoV-2 infection through macrophage-dependent T cell activation...
CDC - DPDx - Echinococcosis
Cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia: a case report from China. | CureHunter
Biomarkers Search
Nutman Research Group | NIH: National Institute of Allergy and Infectious Diseases
Helminth Infections and HIV: A Double Hit
Human cystic echinococcosis in nomads of south-west Islamic Republic of Iran
NIH Clinical Center Search the Studies: Study Number, Study Title
MeSH Browser
WHO EMRO | Prevalence of helminth ova in soil samples from public places in Shiraz | Volume 12, issue 5 | EMHJ volume 12, 2006
Allergy Asthma Clin Immunol Volume 19; 2023 - PMC
Integrated Serologic Surveillance of Population Immunity and Disease Transmission - Volume 24, Number 7-July 2018 - Emerging...
GtR
DeCS
MeSH Browser
Frontiers | Explaining Human Recreational Use of 'pesticides': The Neurotoxin Regulation Model of Substance Use vs. the Hijack...
Pesquisa | Portal Regional da BVS
Ebook - Contemporary Sleep Medicine For Patients
| Bentham Science
MARC details for record no. 23972 › WHO HQ Library catalog
14.4: Eukaryotic Virulence Factors - Biology LibreTexts
Eosinophilia. Medical search
Specimens Associated with Outbreaks of Gastroenteritis
Repeated clinical malaria episodes are associated with modification of the immune system in children | BMC Medicine | Full Text
In vitro characterization of Haemonchus contortus trehalose-6-phosphate phosphatase and its immunomodulatory effects on...
Antigens4
- Immunoglobulins produced in a response to HELMINTH ANTIGENS . (nih.gov)
- All pathogens leave behind immunologic footprints in the form of antibodies that last for months to years and can be detected by testing dried blood spots or serum samples against panels of well-defined antigens. (cdc.gov)
- Antigens, Helminth. (who.int)
- The link could come from molecular similarities between allergens such as dust mites and helminth antigens (worm proteins recognised by the immune system). (mrc.ac.uk)
Monoclonal antibodies2
- Clinical trials using targeted therapies, including imatinib mesylate and monoclonal antibodies to IL-5 and IL-5 receptor, have provided additional insight into the etiology and pathogenesis of HES variants. (nih.gov)
- Dupixent (dupilumab) and Nucala (mepolizumab) are monoclonal antibodies blocking the interaction of IL-4/IL-13 and IL-5, respectively, with their receptors. (healthcarejourney.com)
Soil-transmitted helminths2
- Due to the role of contaminated soil in their transmission, this group of nematode worms are known as soil-transmitted helminths (STH). (cdc.gov)
- Approximately 1.5 billion people in the world (24.0% of the global population) are affected by soil-transmitted helminths, 270 million of whom are preschool-age children. (ophrp.org)
Infection7
- Our work focuses on both the host response to helminth infection and the molecular basis for parasitism in helminths and the prototypical responses they induce. (nih.gov)
- My main project focuses on the role of interleukin-11 in the host immune response to helminth infection. (nih.gov)
- The Human Eosinophil Section conducts basic and translational research related to the role of the eosinophil and eosinophil activation in disease pathogenesis, with the ultimate goal of developing novel diagnostic tools and treatment approaches for hypereosinophilic syndromes and other conditions associated with marked eosinophilia, including helminth infection. (nih.gov)
- Eosinophilia is common in human helminth infection and may be associated with pathologic sequelae that mimic the clinical findings in HES, including tissue fibrosis and "allergic" manifestations. (nih.gov)
- A Randomized, Placebo-controlled, Double-blind Pilot Study of Single-dose Humanized Anti-IL5 Antibody (Reslizumab) for the Reduction of Eosinophilia Following Diethylcarbamazine Treatment of Loa loa Infection. (nih.gov)
- Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1-EPA/Alhydrogel? (umassmed.edu)
- REPC1 antigen is not capable to detect the infection during the first 15 days post-infection, whereas the antibody cannot be detectable. (ac.ir)
Parasitic helminth2
- The focus of the Helminth Immunology Section is the study of host resistance and immune regulation in parasitic helminth infections of global importance. (nih.gov)
- Immune responses to parasitic helminth are usually characterized by quite mysterious phenomena: dominance of Th2-like immunity and antigen-nonspecific IgE secretion. (fujita-hu.ac.jp)
Immunology Section1
- Prior research in the Helminth Immunology Section has demonstrated that these exacerbations are accompanied by an increase in IL-5, eosinophils, and markers of eosinophil activation. (nih.gov)
Responses2
- These responses include the serum IgG1 and IgE responses, the secretory IgA response, and eosinophil-mediated inflammatory responses, such as occur during gut helminth infections and allergic responses, including asthma. (nih.gov)
- We will then use receptor-selective retinoids and RXR-knockout mice to determine, in vivo, if RXR regulates Th2 cell development and Th2-mediated antibody responses. (nih.gov)
Infections4
- 7. Participant with soiled transmitted helminths infections (STH) as diagnosed by microscopy (KK) and/or real-time PCR. (who.int)
- And now a link between allergies and helminth worm infections has emerged, though whether they reduce or worsen symptoms is hotly debated. (mrc.ac.uk)
- To test this idea, researchers asked whether antibodies (the body's defence molecules, red) could latch onto worms in samples from mice with no previous exposure (left), those sensitised to dust mites (middle) and those with immunity from previous helminth infections (right). (mrc.ac.uk)
- Both Dupixent and Nucala are contraindicated in people with parasitic infections and some people with MS treat themselves with parasites (Helminths) to try and treat their disease. (healthcarejourney.com)
DUPIXENT3
- DUPIXENT is a human monoclonal antibody designed to specifically inhibit signaling of two key proteins, IL-4 and IL-13, which are believed to be important contributors of the persistent underlying inflammation in atopic dermatitis, and certain other allergic or atopic diseases. (prnewswire.com)
- Dupixent is a human monoclonal antibody that inhibits the signaling of interleukin-4 (IL-4) and interleukin-13 (IL-13), two key proteins that play a central role in type 2 inflammation that underlies specific types of asthma as well as several other allergic diseases. (salesandmarketingnetwork.com)
- It would not be a good idea for these people on parasitic treatment with Helminths to take either Dupixent or Nucala. (healthcarejourney.com)
Parasites1
- IgE's main function is immunity to parasites such as helminths like Schistosoma mansoni, Trichinella spiralis, and Fasciola hepatica. (thenativeantigencompany.com)
Antigen4
- In the presence of IL-4, DiAg induces mouse B cells to secrete IgE, which is antigen-nonspecific polyclonal antibody. (fujita-hu.ac.jp)
- Differentiate between antigen and antibody. (omtexclasses.com)
- Glycoproteins formed in the body to fight against antigen is called an antibody. (omtexclasses.com)
- METHODS: Dot-ELISA based on the copro-antigen and recombinant EPC1 antigen (rEPC1) for antibody detection was performed. (ac.ir)
Immunity2
- Antibodies are unique among biomarkers in their ability to identify persons with protective immunity to vaccine-preventable diseases and to measure past exposure to diverse pathogens. (cdc.gov)
- Antibody response provides an objective and sensitive way to uncover immunization coverage gaps or waning immunity to vaccine-preventable diseases ( 5 - 7 ) and monitor a population's exposure to malaria ( 8 ), enteric pathogens ( 9 - 12 ), and many NTDs ( 13 - 17 ). (cdc.gov)
Toxoplasma1
- in addition, Toxoplasma oocysts were found in stray cats and antibody response to Toxoplasma in primary-school children [5,6]. (who.int)
Recombinant1
- Recombinant antibodies produced in TRANSGENIC PLANTS . (nih.gov)
Pathogens2
- Robust disease surveillance is a cornerstone of global health efforts that range from detecting emerging pathogens and epidemics to the control or elimination of vaccine-preventable diseases, HIV, malaria, and neglected tropical diseases (NTDs) ( http://www.who.int/neglected_diseases/9789241564540/en/ ) ( 2 - 4 ). (cdc.gov)
- Antibody response can also be a key tool to monitor epidemics, such as HIV ( 18 ) and emerging pathogens ( 16 , 19 ). (cdc.gov)
Proteins1
- The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. (thenativeantigencompany.com)
Prevalence2
- ABSTRACT To determine the prevalence of helminth eggs in public places and children's playgrounds, 112 soil samples were collected in 26 sites in Shiraz, southern Islamic Republic of Iran, during September 2002-September 2003. (who.int)
- As there is a large population of stray dogs and cats in Shiraz and no studies have been made on the extent of contamination of the environment with helminth eggs, this study was undertaken to determine the prevalence of helminth eggs in public places and playgrounds. (who.int)
Malaria1
- Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria. (umassmed.edu)
Immune system2
- If you have an allergy, your immune system overreacts to an allergen by producing IgE antibodies. (thenativeantigencompany.com)
- This property allows antibodies to activate the immune system. (thenativeantigencompany.com)
Detection1
- Blood samples from 3446 individuals from 700 randomly selected families were examined for detection of antibody against Echinococcus granulosus. (who.int)
Serum samples2
Worms1
- Ascaris lumbricoides ( Ascaris or roundworm), Ancylostoma duodenale (hookworm), Necator americanus (hookworm), and Trichuris trichiura (whipworm) are helminths (parasitic worms) that infect the intestine. (cdc.gov)
Vaccine1
- Hence, while use of "generic" vaccine adjuvants, like CFA, to elicit antibody production for research purposes may be fine, that may not be the case when the goal is to develop a protective immune response against a pathogen or malignant cell, as in the case of vaccine development. (biosyn.com)
FORMATION1
- It triggers the formation of antibodies. (omtexclasses.com)
Human3
- Dupilumab was discovered using Regeneron's proprietary VelocImmune ® technology that yields optimized fully-human antibodies, and is being jointly developed by Regeneron and Sanofi under a global collaboration agreement. (prnewswire.com)
- 3. Positive rapid test for HIV 1-2 confirmed by a positive blood test for human immunodeficiency virus (positive antibodies to HIV 1/2). (who.int)
- Dupilumab and REGN3500 were invented using Regeneron's proprietary VelocImmune technology that yields optimized fully-human antibodies. (salesandmarketingnetwork.com)
Levels2
- Antibody levels reflect past exposure over a period of months to years, so cross-sectional surveys contain an immense amount of information about past vaccination and pathogen exposure ( 8 , 20 ). (cdc.gov)
- Seven of these birds had significant levels of neutralizing antibody to duck plague virus. (allenpress.com)
Transmission1
- Guidelines include deworming using annual or biannual single doses of albendazole (400 mg) or mebendazole (500 mg) for eligible groups in the population according to their risk of soil-helminth transmission, with school-age children (5 to 14 years old) being a prioritized group [ 4 , 5 ]. (ophrp.org)
Cells2
- These antibodies travel to cells that release chemicals, causing an allergic reaction. (thenativeantigencompany.com)
- Which cells stimulate B-cells to form antibodies? (omtexclasses.com)
Classes1
- IgE is distinguished from other antibody classes (IgM, IgD, IgG and IgA) by its ε heavy chains. (thenativeantigencompany.com)
Samples1
- Helminth eggs were recovered from 12 of the 112 soil samples. (who.int)
Control2
- Recommended as an immunogen to generate antibodies against mouse anti-IgE-Fc, a standard/control for mouse IgE-Fc assays or other mouse IgE-Fc domain applications. (thenativeantigencompany.com)
- The Colombian Massive Anthelmintic Deworming Guidelines were created in 2013, based on the helminth control guide published by the World Health Organization (WHO). (ophrp.org)
Global1
- First, we argue that antibody-based methods provide a unique opportunity to augment and integrate surveillance across diverse global health initiatives. (cdc.gov)
Virus1
- 5. Participant seropositive for hepatitis C virus (Antibodies to HCV). (who.int)
Structure1
- IgE Antibodies: From Structure to Function and Clinical Translation. (thenativeantigencompany.com)