Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.Epitopes: Sites on an antigen that interact with specific antibodies.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Binding Sites, Antibody: Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.HIV Antibodies: Antibodies reactive with HIV ANTIGENS.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Cell Line: Established cell cultures that have the potential to propagate indefinitely.PolysaccharidesAntibodies, Neoplasm: Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.Antibodies, Protozoan: Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Molecular Weight: The sum of the weight of all the atoms in a molecule.FucoseImmunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.Viral Proteins: Proteins found in any species of virus.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Antibodies, Fungal: Immunoglobulins produced in a response to FUNGAL ANTIGENS.Antigen-Antibody Reactions: The processes triggered by interactions of ANTIBODIES with their ANTIGENS.Mice, Inbred BALB CMannose: A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.GlucosamineImmunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Neuraminidase: An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Glycopeptides: Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.Antibodies, Bispecific: Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Chromatography, Affinity: A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Antibodies, Blocking: Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)Sialic Acids: A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Single-Chain Antibodies: A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.Carbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Mucins: High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase: A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Viral Fusion Proteins: Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Antibodies, Heterophile: Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Antibodies, Catalytic: Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.Epitope Mapping: Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Hybridomas: Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Antigens: Substances that are recognized by the immune system and induce an immune reaction.Galactose Oxidase: An enzyme that oxidizes galactose in the presence of molecular oxygen to D-galacto-hexodialdose. It is a copper protein. EC 126.96.36.199.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Tunicamycin: An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Glycoside HydrolasesKinetics: The rate dynamics in chemical or physical systems.HIV Envelope Protein gp120: External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV.Immunoblotting: Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.Mannosidases: Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE.Virion: The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.Antibodies, Antiphospholipid: Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.Precipitin Tests: Serologic tests in which a positive reaction manifested by visible CHEMICAL PRECIPITATION occurs when a soluble ANTIGEN reacts with its precipitins, i.e., ANTIBODIES that can form a precipitate.Glycoconjugates: Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)Egg Proteins: Proteins which are found in eggs (OVA) from any species.Immunization, Passive: Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).Plant Lectins: Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase: An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. It requires the presence of more than two amino-acid residues in the substrate for activity. This enzyme was previously listed as EC 188.8.131.52.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Galactose: An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.Acetylglucosamine: The N-acetyl derivative of glucosamine.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Hemagglutination Inhibition Tests: Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Lysosome-Associated Membrane Glycoproteins: Ubiquitously expressed integral membrane glycoproteins found in the LYSOSOME.Hemagglutinins, Viral: Specific hemagglutinin subtypes encoded by VIRUSES.Cell Fusion: Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Golgi Apparatus: A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)Gene Products, env: Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Immunosorbent Techniques: Techniques for removal by adsorption and subsequent elution of a specific antibody or antigen using an immunosorbent containing the homologous antigen or antibody.Immunologic Techniques: Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Hemagglutination Tests: Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Acetylgalactosamine: The N-acetyl derivative of galactosamine.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Monosaccharides: Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)Immunoglobulin Fragments: Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.Sindbis Virus: The type species of ALPHAVIRUS normally transmitted to birds by CULEX mosquitoes in Egypt, South Africa, India, Malaya, the Philippines, and Australia. It may be associated with fever in humans. Serotypes (differing by less than 17% in nucleotide sequence) include Babanki, Kyzylagach, and Ockelbo viruses.Glycolipids: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.Wheat Germ Agglutinins: Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Virus Internalization: The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.CHO Cells: CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.Receptors, Concanavalin A: Glycoprotein moieties on the surfaces of cell membranes that bind concanavalin A selectively; the number and location of the sites depends on the type and condition of the cell.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Vero Cells: A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.Amino Sugars: SUGARS containing an amino group. GLYCOSYLATION of other compounds with these amino sugars results in AMINOGLYCOSIDES.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Immunodiffusion: Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Cell Adhesion: Adherence of cells to surfaces or to other cells.Zona Pellucida: A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.Membrane Fusion: The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.Sialyltransferases: A group of enzymes with the general formula CMP-N-acetylneuraminate:acceptor N-acetylneuraminyl transferase. They catalyze the transfer of N-acetylneuraminic acid from CMP-N-acetylneuraminic acid to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. EC 2.4.99.-.Asialoglycoproteins: Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)HN Protein: Glycoprotein from Sendai, para-influenza, Newcastle Disease, and other viruses that participates in binding the virus to cell-surface receptors. The HN protein possesses both hemagglutinin and neuraminidase activity.Periodic Acid: A strong oxidizing agent.alpha-Mannosidase: An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.HIV Envelope Protein gp41: Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. It has a molecular weight of 41,000 and is glycosylated. The N-terminal part of gp41 is thought to be involved in CELL FUSION with the CD4 ANTIGENS of T4 LYMPHOCYTES, leading to syncytial formation. Gp41 is one of the most common HIV antigens detected by IMMUNOBLOTTING.Herpesvirus 1, Suid: A species of VARICELLOVIRUS producing a respiratory infection (PSEUDORABIES) in swine, its natural host. It also produces an usually fatal ENCEPHALOMYELITIS in cattle, sheep, dogs, cats, foxes, and mink.Immunoglobulin Variable Region: That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.Galactosyltransferases: Enzymes that catalyze the transfer of galactose from a nucleoside diphosphate galactose to an acceptor molecule which is frequently another carbohydrate. EC 2.4.1.-.Complement Fixation Tests: Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.Immunoglobulins: Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.OrosomucoidHemagglutinin Glycoproteins, Influenza Virus: Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Haptens: Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.IndolizinesAntigens, CD4: 55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.Neuraminic AcidsSialoglycoproteins: Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Vaccination: Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Hepatitis C Antibodies: Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.Antibodies, Antineutrophil Cytoplasmic: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.env Gene Products, Human Immunodeficiency Virus: Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Giant Cells: Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.Calnexin: A lectin found in ENDOPLASMIC RETICULUM membranes that binds to specific N-linked OLIGOSACCHARIDES found on newly synthesized proteins. It may play role in PROTEIN FOLDING or retention and degradation of misfolded proteins in the endoplasmic reticulum.Seroepidemiologic Studies: EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.Mice, Inbred C57BLComplement System Proteins: Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).Vaccines, Synthetic: Small synthetic peptides that mimic surface antigens of pathogens and are immunogenic, or vaccines manufactured with the aid of recombinant DNA techniques. The latter vaccines may also be whole viruses whose nucleic acids have been modified.Radioimmunoprecipitation Assay: Sensitive assay using radiolabeled ANTIGENS to detect specific ANTIBODIES in SERUM. The antigens are allowed to react with the serum and then precipitated using a special reagent such as PROTEIN A sepharose beads. The bound radiolabeled immunoprecipitate is then commonly analyzed by gel electrophoresis.Immunoglobulin Idiotypes: Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.Isoantibodies: Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.Variant Surface Glycoproteins, Trypanosoma: Glycoproteins attached to the surface coat of the trypanosome. Many of these glycoproteins show amino acid sequence diversity expressed as antigenic variations. This continuous development of antigenically distinct variants in the course of infection ensures that some trypanosomes always survive the development of immune response to propagate the infection.Immunochemistry: Field of chemistry that pertains to immunological phenomena and the study of chemical reactions related to antigen stimulation of tissues. It includes physicochemical interactions between antigens and antibodies.Iodine Radioisotopes: Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Immunoglobulin Isotypes: The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.Spleen: An encapsulated lymphatic organ through which venous blood filters.Agglutinins: Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
AntiMOG associated encephalomyelitis
Antibodies against the Myelin oligodendrocyte glycoprotein have received much of its laboratory attention in studies dealing ... 2012). "Myelin-oligodendrocyte glycoprotein antibodies in adults with a neuromyelitis optica phenotype". Neurology. 79 (12): ... "Anti-myelin oligodendrocyte glycoprotein antibody in demyelinating diseases". Clinical and Experimental Neuroimmunology. 6: 59- ... 2011). "Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders ...
Multiple sclerosis research
Ichiro Nakashima (December 2015). "Anti-myelin oligodendrocyte glycoprotein antibody in demyelinating diseases". ... While monoclonal antibodies are probably going to have some role in the treatment of the disease in the future, it is believed ... Monoclonal antibodies, which are drugs of the same family as natalizumab, have also raised high levels of interest and research ... Related to these investigations is the recent development of a test against JC virus antibodies which might help to predict ...
Technetium (99mTc) nofetumomab merpentan
Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM. and/or CD20/MS4A1 It is the ... The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc ... Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis ... p533 technetium (99mTc) nofetumomab merpentan (TAB-711) Monoclonal Antibody Radionuclide Test Kits Insecticidal composition and ...
C. parvum glycoproteins have the characteristics of attractive vaccine candidates. Many are immunodominant, and antibodies ... Indeed, the structure of GP900 is similar to that of a family of glycoproteins known as mucins. GP900 is thought to mediate ... In vitro, hyperimmune sera, as well as antibodies directed at specific epitopes on the GP900 protein, inhibit the invasion of C ... of Cryptosporidium parvum Infection In Vitro by Mucin-Like Glycoproteins Defined by a Neutralizing Monoclonal Antibody". Infect ...
Universal flu vaccine
Krammer F (May 2017). "Strategies to induce broadly protective antibody responses to viral glycoproteins". Expert Review of ... 2016 BBC: 'Super antibody' fights off flu Independent: Scientists hail the prospect of a universal vaccine for flu "Universal ... In July 2011, researchers created an antibody, which targets a protein found on the surface of all influenza A viruses called ... F16 is the only known antibody that binds (its neutralizing activity is controversial) to all 16 subtypes of the influenza A ...
Satish K. Gupta
The team led by him has carried out elaborate investigations on Zona pellucida, a layer of glycoprotein enveloping the plasma ... SK Gupta, T Bagchi, U Deshmuck, R Gupta, H Bagawant, M Shamim (1992). "Monoclonal Antibodies: Their Production and Applications ... "Isolation of a High Affinity Neutralizing Monoclonal Antibody against 2009 Pandemic H1N1 Virus That Binds at the 'Sa' Antigenic ... "Contraceptive Vaccines Based on the Zona Pellucida Glycoproteins for Dogs and Other Wildlife Population Management". Am J ...
RCN vaccine-laden baits increased antibodies against plague in both antigens. In contrast to known members of the poxvirus ... The rRCN rabies virus glycoprotein recombinant vaccine was effective when given to sheep both intradermally and intramuscularly ... Of the 92 apparently healthy raccoons trapped near Aberdeen, Maryland in 1961, 22 had sera containing RCN HA1 antibodies. The ... Promoting rabies virus neutralizing antibodies in raccoons, dogs, cotton rats, rabbits, bobcats, and foxes; sometimes at lethal ...
P-glycoprotein expression in primary breast cancer detected by immunocytochemistry with two monoclonal antibodies. Br J Cancer ... P-glycoprotein expression in primary breast cancer detected by immunocytochemistry with two monoclonal antibodies. Br J Cancer ... P-glycoprotein expression is associated with sestamibi washout in primary hyperparathyroidism. British Journal of Surgery, 2007 ... In 1990, Gordon Wishart identified that P-glycoprotein, a trans-membrane export pump involved in multidrug resistance, was ...
Many "blockbuster" therapeutic proteins in the market are antibodies, which are N-linked glycoproteins. For example, Etanercept ... The nature of N-linked glycans attached to a glycoprotein is determined by the protein and the cell in which it is expressed. ... The synthesis of glycoproteins is thus spatially separated in different cellular compartments. Therefore, the type of N-glycan ... The removal of the final glucose residue signals that the glycoprotein is ready for transit from the ER to the cis-Golgi. ...
The thogotovirus glycoprotein is not similar to the influenza virus glycoproteins (haemagglutinin and neuraminidase), and ... Antibodies have been found to THOV in rats and many domestic animals, including goats, sheep, donkeys, camels, cattle and ... "The glycoprotein of Thogoto virus (a tick-borne orthomyxo-like virus) is related to the baculovirus glycoprotein GP64", ... The thogotovirus glycoprotein is classified as a class III or γ penetrene, lacking the fusion peptide present in influenza ...
1995). "Interaction of complement and specific antibodies with the external glycoprotein 120 of HIV-1". Immunology. 85 (2): 184 ... 1994). "The envelope glycoprotein of HIV-1 gp120 and human complement protein C1q bind to the same peptides derived from three ... 1994). "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of ... 1994). "Studies on the mechanism of complement-mediated inhibition of antibody binding to HIV gp41". Clin. Exp. Immunol. 94 (3 ...
"Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody". The Journal of Neuroscience. 17 (1): 23-31. ... a glycoprotein secreted by Cajal-Retzius cells in the developing brain. This protein seems to act as a stop signal for ... the glycoprotein reelin is 50% downregulated. In the brains of patients with autism, structural abnormalities in the neocortex ... detecting antigens by exploiting the principle of antibodies binding specifically to antigens in biological tissues) showed ...
Myelin-oligodendrocyte glycoprotein antibody-positive patients were more likely to have conus involvement on spinal magnetic ... antibody-independent, molecular signatures of MS, AQP4-antibody and MOG-antibody disease". Acta Neuropathol Commun. 5 (1): 95. ... Though the disease is known to be auto-antibodies mediated, B-cell depletion has been tried with the monoclonal antibody ... or simply NMO antibodies. These antibodies target the protein aquaporin 4 in the cell membranes of astrocytes which acts as a ...
HIV-1 envelope glycoprotein contains at least four sites for neutralizing antibodies. Among these sites, the membrane-proximal ... These antibodies are usually picked up in young women with recurrent spontaneous abortions. In anti-cardiolipin-mediated ... Hokama Y, Campora CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K. Anticardiolipin antibodies in the sera of patients with ... Anti-cardiolipin antibodies can also be increased in numerous other conditions, including systemic lupus erythematosus, malaria ...
It has also developed a monoclonal antibody (R813) to human platelet surface glycoprotein IIIa. The Phase I clinical trial has ... S20030093 Monoclonal antibodies recognizing human platelet membrane glycoproteins and use thereof in anti-thrombotic therapy [3 ... "Therapeutic monoclonal antibody developed in Xuzhou, China for treatment of Alzheimer's disease". Archived from the original on ... "Therapeutic Monoclonal Antibody for Early Detection and Treatment of Alzheimer's Disease Approved by Chinese Academy of ...
All women generated antibodies against hCG, but only 119 (80%) generated antibody titers clearly above 50 ng/mL, which was the ... The zona pellucida is a glycoprotein membrane surrounding the plasma membrane of an ovum. The zona pellucida's main function in ... In passive immunity the desired antibody titers are achieved by injecting antibodies directly into an animal. The efficacy of ... anti-sperm antibodies are not likely to have adverse health effects, since anti-sperm antibodies are produced by up to 70% of ...
They range from glycoproteins in cell surface membranes that constitute the glycocalyx, to important antibodies produced by ... Glycoproteins are generally the largest and most abundant group of conjugated proteins. ... Some examples of conjugated proteins are lipoproteins, glycoproteins, phosphoproteins, hemoproteins, flavoproteins, ...
If antibodies against the protein are available then western blotting and ELISA can specifically detect and quantify the amount ... Proteins that do not bind to the lectin are washed away and then specifically bound glycoproteins can be eluted by adding a ... The immobilized ligand can be an antibody (such as Immunoglobulin G) or it can be a protein (such as Protein A). Because this ... If the desired protein is an antibody, binding can be translated directly to the activity of the protein. One can express the ...
... is a 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly ... 1994). "BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating ... PD-1 antibodies. CD160 has also been proposed as a potential new target in cases of human pathological ocular and tumor ...
Venereal Disease Research Laboratory test
Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... The syphilis anti-cardiolipin antibodies are beta-2 glycoprotein independent, whereas those that occur in the antiphospholipid ... "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but ... antibody syndrome (associated to lupus for example) are beta-2 glycoprotein dependent, and this can be used to tell them apart ...
In autoimmune disease, anti-apolipoprotein antibodies (Anti β2 glycoprotein I antibodies) strongly associate with thrombotic ... Shi W, Chong BH, Hogg PJ, Chesterman CN (1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of ... Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... Apolipoprotein H (Apo-H), previously known as β2-glycoprotein I and beta-2 glycoprotein I, is a 38 kDa multifunctional ...
These stains use antibodies to bind to specific antigens, usually of protein or glycoprotein origin. Since antibodies are ... Example 3. An untagged primary antibody is detected using a general secondary antibody that recognises all antibodies ... Monoclonal antibodies that consist of only one type of antibody tend to provide greater antigen specificity, and also tend to ... Simply, a very thin slice of tissue is fixed onto glass, incubated with antibody or a series of antibodies, the last of which ...
Complement component 5
Arribas J, Arizti P, Castaño JG (1994). "Antibodies against the C2 COOH-terminal region discriminate the active and latent ... 1996). "Identification of complement activation sites in human immunodeficiency virus type-1 glycoprotein gp120". Blood. 87 (6 ... 1994). "Complement activation by recombinant HIV-1 glycoprotein gp120". J. Immunol. 152 (12): 6028-34. PMID 7911492. ...
Most antibodies have the similar structure except the hypervariable region which is called the antigen binding site. This ... Many of these interactions involved carbohydrates found at the cell surface, as part of a membrane glycoprotein or glycolipid. ... Generally, there are two types of protein carbohydrate binding important in biological processes: Lectin and antibody. Lectin ... Intramolecular carbohydrate-protein interactions refer to interactions between glycan and polypeptide moieties in glycoproteins ...
Butyrophilin, subfamily 1, member A1
"Antibody cross-reactivity between myelin oligodendrocyte glycoprotein and the milk protein butyrophilin in multiple sclerosis ... Butyrophilin has been presented as a potential antigen which may be similar enough to myelin oligodendrocyte glycoprotein (MOG ... 1983). "Butyrophilin, an apical plasma membrane-associated glycoprotein characteristic of lactating mammary glands of diverse ... modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune ...
Roselyn J. Eisenberg
Antibody-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein gD Reveal New Targets for Virus Neutralization. ... "Antibody-induced conformational changes in herpes simplex virus glycoprotein gD reveal new targets for virus neutralization". ... of three glycoproteins. These glycoproteins gB, gH, and gL play important roles in how a virus enters a cell and how it spreads ... Crystal Structure of Glycoprotein B From Herpes Simplex Virus 1 A Protein-based Smallpox Vaccine Protects Mice From Vaccinia ...
Low-density lipoprotein receptor-related protein 8
It is caused by the presence of antibodies against anionic phospholipids and β2-glycoprotein I (β2GPI). The anti-β2GPI ... Lutters BC, Derksen RH, Tekelenburg WL, Lenting PJ, Arnout J, de Groot PG (2003). "Dimers of beta 2-glycoprotein I increase ... When bound by an antibody, β2GPI begins to interact with monocytes, endothelial cells, and platelets. ApoER2 is thought to play ... There is also speculation that the antibody/β2GPI complexes sensitize other cell types through various LDL family receptors to ...
"Product Overview: anti-CD68 Antibodies". www.antibodies-online.com. Retrieved 14 September 2017. Dijkstra, CD; Döpp, EA; Joling ... Cluster of differentiation Lysosome-associated membrane glycoprotein Scavenger receptor (immunology) Holness CL, Simmons DL ( ... Anti-CD68 monoclonal antibodies that react with tissues of rodent and other species include ED1, FA-11, KP1 (a.k.a. C68/684), ... ED1 is the most widely used monoclonal antibody clone directed against the rat CD68 protein and is used to identify macrophages ...
Michael A. Epstein
After infection, a secreted glycoprotein, small soluble glycoprotein (sGP or GP) is synthesised. EBOV replication overwhelms ... IgM antibodies are detectable two days after symptom onset and IgG antibodies can be detected six to 18 days after symptom ... Finding the virus, viral RNA, or antibodies in blood. Differential diagnosis. Malaria, cholera, typhoid fever, meningitis, ... Survivors develop antibodies against Ebola that last at least 10 years, but it is unclear whether they are immune to additional ...
Genetically modified tomato
... antibodies for the virus, or the virus itself in cell culture. Other conditions that may present similarly include Ebola, ... vaccine against Lassa virus based on recombinant vesicular stomatitis virus vectors expressing the Lassa virus glycoprotein. ... An ELISA test for antigen and Immunoglobulin M antibodies give 88% sensitivity and 90% specificity for the presence of the ...
The level of A1AT in serum is most often determined by adding an antibody that binds to A1AT, then using turbidimetry to ... Acute-phase glycoproteins: molecular biology, biochemistry and clinical applications. CRC Press. pp. 3-19. DeMeo DL, Silverman ... A1AT is a single-chain glycoprotein consisting of 394 amino acids in the mature form and exhibits many glycoforms. The three N- ...
Antibody - Simple English Wikipedia, the free encyclopedia
Antibodies are glycoproteins belonging to the immunoglobulin superfamily; the terms antibody and immunoglobulin are often used ... The antibody recognizes a unique part of the foreign target called an antigen. Each tip of the "Y" of an antibody ... These allow vertebrate B cells to generate a huge pool of antibodies from a relatively small number of antibody genes. The ... There are several different types of antibody heavy chains, and several different kinds of antibodies, which are grouped into ...
Index of HIV/AIDS-related articles
... antibodies - antibody-dependent cell-mediated cytotoxicity (ADCC) - antibody-mediated immunity - antifungal medication - ... glycoprotein - gonorrhea - gp120 (gp120) - gp160 (gp160) - gp41 (gp41) - granulocyte - granulocyte macrophage-colony ... neutralizing antibody - neutralizing domain - neutropenia - neutrophil - New Drug Application (NDA) - New York Cares - NIAID - ... functional antibody - fungus - fusin - fusion inhibitor - fusion mechanism - fusion peptide ...
CD200 - Википедия
Wright G.J., Puklavec M.J., Willis A.C. et al. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on ... Chen D.X., Gorczynski R.M. Discrete monoclonal antibodies define functionally important epitopes in the CD200 molecule ... McCaughan G.W., Clark M.J., Barclay A.N. Characterization of the human homolog of the rat MRC OX-2 membrane glycoprotein (англ ... Мембранный гликопротеин OX-2 (англ. OX-2 membrane glycoprotein; CD200) - мембранный белок суперсемейства иммуноглобулинов, ...
... since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a ... The testing of antibodies to the possible individual targets of aPL such as β2 glycoprotein 1 and antiphosphatidyl serine is ... Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with ... A low platelet count and positivity for antibodies against β2-glycoprotein 1 or phosphatidylserine may also be observed in a ...
Brain-derived neurotrophic factor
Innate immune system
The complement system is a biochemical cascade of the immune system that helps, or "complements", the ability of antibodies to ... endothelial cells (via passive diffusion/ osmosis & active selection). P-glycoprotein (mechanism by which active transportation ... Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead ... Invertebrates do not possess lymphocytes or an antibody-based humoral immune system, and it is likely that a multicomponent, ...
Platelet-derived growth factor
... is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ... Such antagonists include (but are not limited to) specific antibodies that target the molecule of interest, which act only in a ... "An antibody reactive with domain 4 of the platelet-derived growth factor beta receptor allows BB binding while inhibiting ...
Human digestive system
Saliva also contains a glycoprotein called haptocorrin which is a binding protein to vitamin B12. It binds with the vitamin ... It also has an immunological role in supplying antibodies to the system, such as immunoglobulin A. This is seen to be key ... The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the ... The main component of mucus is a glycoprotein called mucin and the type secreted varies according to the region involved. Mucin ...
... they are antigens to which antibodies can be raised. Influenza A viruses are classified into subtypes based on antibody ... Hemagglutinin (HA) and neuraminidase (NA) are the two large glycoproteins on the outside of the viral particles. HA is a lectin ... The influenza A virus can be subdivided into different serotypes based on the antibody response to these viruses. The ... There has been some research success towards a "universal flu vaccine" that produces antibodies against proteins on the viral ...
... the family is named after antibodies (also called immunoglobulins). The TCR is similar to a half-antibody consisting of a ... Whereas the antibody uses its Fc region to bind to Fc Receptors on leukocytes, TCR is already docked onto the cell membrane. ... The generation of TCR diversity is similar to that for antibodies and B cell antigen receptors. It arises mainly from genetic ... antibodies) and TCR is unique to lymphocytes (T and B cells) during the early stages of their development in primary lymphoid ...
... is an important parameter in the optimization of many glycoprotein-based drugs such as monoclonal antibodies. ... Aglycosylation is a feature of engineered antibodies to bypass glycosylation. Five classes of glycans are produced: *N- ... Glycoprotein diversity. Glycosylation increases diversity in the proteome, because almost every aspect of glycosylation ... Secondly, N-linked glycans mediate a critical quality control check point in glycoprotein folding in the endoplasmic reticulum. ...
Glycoproteins. *Antibodies. Hidden categories: *Pages with DOIs inactive since 2018. *Articles with inconsistent citation ... "Antibody structure". Archived from the original on September 6, 2008.. *^ Erb KJ (2007). "Helminths, allergic disorders and IgE ... Chang TW, Wu PC, Hsu CL, Hung AF (2007). Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases. Adv. Immunol ... Immunoglobulin E (IgE) is a type of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is ...
Brain-derived neurotrophic factor
December 2010). "Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography". Nature. 468 (7324 ... an antibody that is a response to the initial exposure to an antigen, appears in the blood, viremia begins to diminish. However ... Diagnosis is by either testing the blood for the virus's RNA or antibodies to the virus. The symptoms can be mistaken for ... and attenuation was found to be due to only two mutations in the E2 glycoprotein. Alternative vaccine strategies have been ...
Both anti-glycoprotein-210 (anti-gp210) and anti-nucleoporin 62 (anti-p62) antibodies are antibodies to components of the ... anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to ... This pattern is associated with anti-dsDNA antibodies, antibodies to nucleosomal components, and anti-histone antibodies. There ... Anti-histone antibodies. Anti-histone antibodies are found in the serum of up to 75-95% of people with drug induced lupus ...
... s are iron-binding blood plasma glycoproteins that control the level of free iron (Fe) in biological fluids. ... Transferrin and its receptor have been shown to diminish tumour cells when the receptor is used to attract antibodies. ... Transferrin glycoproteins bind iron tightly, but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of ...
IL-15 is 14-15 kDa glycoprotein encoded by the 34 kb region of chromosome 4q31 in humans, and at the central region of ... In one study with mice blocking IL-15 with an antibody led to the reversal of autoimmune intestinal damage. In another ... Figure 1. IL-15 is 14-15 kDa glycoprotein encoded by the 34 kb region on chromosome 4q31, and by central region of chromosome 8 ... "Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in ...
Idiotype Network theory, proposed by Jerne, wherein a network of antibodies capable of neutralizing self-reactive antibodies ... linkages common to lower eukaryotes and prokaryotes on the glycoproteins of mammalian non-hematopoietic cells and organs ... 2002) injected an anti-MHC Class II antibody into mice expressing a single type of MHC Class II molecule (H-2b) to temporarily ... In this case, the host-cell receptor is envisioned as an internal image of the virus, and the anti-idiotype antibodies can ...
Меланотрансферрин - Википедия
Antibody-drug conjugates. Antibody-drug conjugates (ADCs) comprise an antibody, drug and a linker between them. The ... Generating Inhibitors of P-Glycoprotein: Where to, Now?. Springer Protocols. pp. 405-432.. ... Sievers EL, Linenberger M (Nov 2001). "Mylotarg: antibody-targeted chemotherapy comes of age". Current Opinion in Oncology. 13 ... They are divided into two groups: small molecule and antibodies. The massive toxicity seen with the use of cytotoxics is due to ...
Brehler, R.; Theissen, U.; Mohr, C.; Luger, T. (1997). "'Latex-fruit syndrome': frequency of cross-reacting IgE antibodies". ... Kolarich, Daniel; Altmann, Friedrich; Sunderasan, Elumalai (2006). "Structural analysis of the glycoprotein allergen Hev b 4 ... The immune system of some susceptible individuals produces antibodies that react immunologically with these antigenic proteins. ... "Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies". Molecular Immunology. 46 (4): ...
Specific Interference with the Determination of the Tumour-Associated Glycoprotein 72 by Human Anti-Idiotypic Antibodies Formed...
Anti-glycoprotein-210 antibodies - Wikipedia
Anti-glycoprotein-210 antibodies (AGPA, anti-gp210, anti-nup210, anti-np210) are directed at gp210 and are found within primary ... The glycoprotein gp210 is commonly used in the literature. The gene, NUP210, encodes the nuclear pore (nuclear porin) ... 2005). "Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis". J. ... Anti-mitochondrial, anti-centromere and anti-p62 antibodies are also found in (PBC). While patients with AGPA progress toward ...
Adhesion-Related Integral Membrane Glycoproteins Identified by Monoclonal Antibodies | SpringerLink
Adhesion-inhibiting polyclonal antibodies were first used by Gerisch (1977) to identify glycoproteins responsible for ... Adhesion-related glycoproteins isolated using a monoclonal antibody, J. Cell Biol. 95:111a. (abstract).Google Scholar ... Adhesion-Related Integral Membrane Glycoproteins Identified by Monoclonal Antibodies. In: Kennett R.H., Bechtol K.B., McKearn T ... Neff, N. T., Lowrey, C., Decker, C., Tovar, A., Damsky, C., Buck, C., and Horwitz, A. F., 1982, A monoclonal antibody detaches ...
Patent US5766946 - Monoclonal antibodies to glycoprotein P - Google Patents
The monoclonal antibody has a continuous amino acid sequence, and a binding affinity for the P-glycoprotein which manifests in ... A monoclonal antibody that recognises a structurally continuous and extracellularly-located epitope of human P-glycoprotein is ... The monoclonal antibody has a continuous amino acid sequence, and a binding affinity for the P-glycoprotein which manifests in ... The monoclonal antibody has a continuous amino acid sequence, and a binding affinity for the P-glycoprotein which manifests in ...
Beta 2 Glycoprotein I Antibody
Beta-2 Glycoprotein 1 Antibodies | Lab Tests Online
... when a beta-2 glycoprotein 1 antibodies test is ordered; and what the results of the test might mean ... Describes how a beta-2 glycoprotein 1 antibodies test is used to help diagnose antiphospholipid syndrome (APS), determine the ... Beta-2 glycoprotein 1 antibody tests are primarily used along with cardiolipin antibody and lupus anticoagulant testing to help ... Beta-2 glycoprotein antibody is considered one of the primary autoantibodies called antiphospholipid antibodies that mistakenly ...
Myelin Associated Glycoprotein (MAG) Antibody, IgM
Monoclonal antibodies against human platelet glycoprotein IIIa. - PubMed - NCBI
Monoclonal antibodies against human platelet glycoprotein IIIa.. Tetteroo PA, Lansdorp PM, Leeksma OC, von dem Borne AE. ... One of these anti-GP-IIIa antibodies (C17) inhibited both ADP- and collagen-induced platelet aggregation as well as ADP-induced ... The other anti-GP-IIIa antibody (C15) also caused a complete inhibition of aggregation with collagen. However, a small, and ... Neither of the monoclonal anti-GP-IIIa antibodies blocked the binding to Zwa-positive platelets of human polyclonal anti-Zwa ...
Anti-P Glycoprotein antibody (ab226937) | Abcam
Rabbit polyclonal P Glycoprotein antibody. Validated in WB, ICC/IF and tested in Human. Immunogen corresponding to synthetic ... Primary antibodies. Secondary antibodies. ELISA and Matched Antibody Pair Kits. Cell and tissue imaging tools. Cellular and ... Primary - Rabbit Anti-P Glycoprotein antibody (ab226937) ICC/IF, WB Secondary - Goat Anti-Rabbit IgG H&L (HRP) (ab205718) IHC-P ... All lanes : Anti-P Glycoprotein antibody (ab226937) at 1/500 dilution. Lane 1 : HepG2 (human liver hepatocellular carcinoma ...
Anti-envelope glycoprotein Antibody Products | Biocompare
Compare Anti-envelope glycoprotein Antibody Products from leading suppliers on Biocompare. View specifications, prices, ... Anti-envelope glycoprotein Antibody Products. Listed below are anti-Envelope glycoprotein antibodies from multiple suppliers. ... This BioLegend Antibody Is Great for Identifying CD8b+ T Cells The antibody is great for identifying the CD8b+ population of T ... Rabbit anti-Human herpesvirus 1 Envelope glycoprotein G polyclonal Antibody; FITC conjugated ...
Anti-Oligodendrocyte myelin glycoprotein antibody (ab96426)
Rabbit polyclonal Oligodendrocyte myelin glycoprotein antibody validated for WB and tested in Human. With 1 independent review ... Anti-Oligodendrocyte myelin glycoprotein antibody. See all Oligodendrocyte myelin glycoprotein primary antibodies. ... Primary antibodies. Secondary antibodies. ELISA, Matched Antibody Pairs and Multiplex Immunoassays. Cell and tissue imaging ... Anti-Oligodendrocyte myelin glycoprotein antibody (ab96426) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg. Predicted ...
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. - PubMed - NCBI
Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.. Lok SM1, Kostyuchenko V, ... Nevertheless, antibody could bind to the virus at 37 degrees C, suggesting that the virus is in dynamic motion making hidden ... The monoclonal antibody 1A1D-2 has been shown to strongly neutralize dengue virus serotypes 1, 2 and 3, primarily by inhibiting ... A crystal structure of its antigen binding fragment (Fab) complexed with domain III of the viral envelope glycoprotein, E, ...
Thermo Scientific Phadia 2-Glycoprotein I Antibodies for Antiphospholipid
Thermo Scientific Phadia 2-Glycoprotein I Antibodies for Antiphospholipid Syndrome EliA Beta2-Glycoprotein I IgA; Equivocal: 7 ... After washing away non-bound antibodies, enzyme-labeled antibodies against human IgG (IgM, IgA) antibodies (EliA IgG, IgM, IgA ... Thermo Scientific Phadia β 2-Glycoprotein I Antibodies for Antiphospholipid Syndrome Intended for the in vitro quantitative ... In-vitro quantitative measurement of Antibodies directed to beta2-Glycoprotein I in Human Serum and Plasma to aid in the ...
Myelin Oligodendrocyte Glycoprotein(MOG)Antibody with Reflex to Titer,Serum
The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and ... MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis ... The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). ... Myelin oligodendrocyte glycoprotein,MOG-IgG,LETM antibody,Optic Neuritis Antibody,ADEM antibody,NMOSD ...
Protection from cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies | PNAS
1991) Antibody response to human cytomegalovirus glycoproteins gB and gH after natural infection in humans. J Infect Dis 164: ... The administration of a subunit vaccine based on the key viral glycoprotein B of HCMV is a potent inducer of anti-gB antibodies ... Most likely, these potent antibodies are a composite of anti-gB and other major glycoprotein targets including the trimer gH/gL ... Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity antibodies in the absence of neutralizing antibodies ...
Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with ... OBJECTIVE: To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of ... Myelin-Associated Glycoprotein / blood, cerebrospinal fluid*, immunology*. Myelin-Oligodendrocyte Glycoprotein. Prospective ... 0/MOG protein, human; 0/Myelin Proteins; 0/Myelin-Associated Glycoprotein; 0/Myelin-Oligodendrocyte Glycoprotein ...
myelin oligodendrocyte glycoprotein antibodies | Journal of Neurology, Neurosurgery & Psychiatry
Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis |...
Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis. ... Serum antibodies to conformational and linear epitopes of myelin oligodendrocyte glycoprotein are not elevated in the ... Antibodies to myelin oligodendrocyte glycoprotein as a biomarker in multiple sclerosis - are we there yet? ... Antibodies to native myelin oligodendrocyte glycoprotein are serologic markers of early inflammation in multiple sclerosis ...
RCSB PDB - 5NUZ: Junin virus GP1 glycoprotein in complex with an antibody Fab fragment
Junin virus GP1 glycoprotein in complex with an antibody Fab fragment. *DOI: 10.2210/pdb5NUZ/pdb ... Pre-glycoprotein polyprotein GP complex. C, D. 156. Argentinian mammarenavirus. Mutation(s): 0 Gene Names: GPC. ... Despite differences in GP1 recognition, we find that both antibodies present a key tyrosine residue, albeit on different chains ... These data provide a molecular-level description of how antibodies derived from different germline origins arrive at equivalent ...
Heartland Virus Glycoprotein 1 Antibodies: Novus Biologicals
Browse our Heartland Virus Glycoprotein 1 Antibody catalog backed by our Guarantee+. ... Heartland Virus Glycoprotein 1 Antibodies available through Novus Biologicals. ... Heartland Virus Glycoprotein 1 Antibodies. We offer Heartland Virus Glycoprotein 1 Antibodies for use in common research ... Choose from our Heartland Virus Glycoprotein 1 polyclonal antibodies.. Alternate Names for Heartland Virus Glycoprotein 1 ...
P-Glycoprotein Antibody (PA5-88245)
This antibody reacts with Human, Mouse, Rat samples. Supplied as 100 µL purified antibody (2.86 mg/mL). ... Invitrogen Anti-P-Glycoprotein Polyclonal, Catalog # PA5-88245. Tested in Western Blot (WB), Immunofluorescence (IF), ... Cite P-Glycoprotein Polyclonal Antibody. The following product was used in this experiment: P-Glycoprotein Polyclonal Antibody ... P glycoprotein 1; P glycoprotein 3; P-glycoprotein 1; P-glycoprotein 3; P-glycoprotein/multidrug resistance 1; Phospholipid ...
P-Glycoprotein Antibody (MA5-32282)
This antibody reacts with Canine, Human, Mouse, Rat samples. Supplied as 100 µL purified antibody (1 mg/mL). ... Invitrogen Anti-P-Glycoprotein Recombinant Monoclonal (SN06-42), Catalog # MA5-32282. Tested in Western Blot (WB) and ... P glycoprotein 1; P glycoprotein 3; P-glycoprotein 1; P-glycoprotein 3; P-glycoprotein/multidrug resistance 1; Phospholipid ... P-Glycoprotein Recombinant Rabbit Monoclonal Antibody (SN06-42). Advanced Verification This Antibody was verified by Relative ...
Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome
Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome
... but with persistently negative consensus antiphospholipid antibodies (a-PL). IgA anti-β2 Glycoprotein I (aB2-GPI) antibodies ... Isolated IgA Anti-β2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome. Raquel Ruiz- ... In patients with arterial thrombosis IgA aB2GPI, antibodies were the only aPL antibodies present. Serologic profile in primary ... to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other aPL antibodies. Only 14 ...
Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA(HerpeSelect)
... ,ARUP Laboratories is a national ... Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA(HerpeSelect). ... Herpes Simplex Virus Type 2 Glycoprotein G-Specific Antibody, IgG by ELISA(HerpeSelect). ... Herpes Simplex Virus Type 1 (HSV-1) Antibody Test Kit - IgM. 10. Herpes Simplex Virus Type 2 (HSV-2) Test Kit - IgG. 11. Herpes ...
Ebola virus glycoprotein and antibody - Stock Image - C025/2299 - Science Photo Library
Molecular model of a surface glycoprotein from the Ebola virus (EBOV) bound to an antibody. ... Ebola virus glycoprotein and antibody. Molecular model of a surface glycoprotein from the Ebola virus (EBOV) bound to an ... antibody. Ebola causes a severe, and often fatal disease in humans and nonhuman primates (monkeys, gorillas and chimpanzees). ...
Role of glycoproteins of pseudorabies virus in eliciting neutralizing antibodies
... in eliciting the production of neutralizing antibodies during the normal course of infection of swine. They also address the ... The experiments described in this paper were designed to assess the role of the various virus glycoproteins of pseudorabies ... No antigenic drift in glycoprotein gII was observed. Glycoprotein gIII and, to some extent, also glycoprotein gI showed a high ... Role of glycoproteins of pseudorabies virus in eliciting neutralizing antibodies Virology. 1986 Oct 30;154(2):325-34. doi: ...
Webinar: Applying Best in Class Size Exclusion Chromatography Technologies to the Analysis of Antibodies and Glycoproteins |...
This webinar focuses on the versatile use of size exclusion chromatography in analysing Antibodies and Glycoproteins. We cover ... Webinar: Applying Best in Class Size Exclusion Chromatography Technologies to the Analysis of Antibodies and Glycoproteins. ... Learn about the use of versatile analytical techniques including oligosaccharide analysis, monoclonal antibody aggregate ... interaction chromatography as well as the use of buffer additives in size exclusion chromatography of monoclonal antibodies. ...
Antibody against human endometrial stromal cell glycoprotein - Patent # 5831035 - PatentGenius
... inhibited secretory glycoprotein specifically from stromal cells of endometrial origin. The protein has the molecular weight of ... An antibody to the purified and isolated glycoprotein and functional analogs thereof characterized by being progesterone ... Antibodies may be generated from isolated, partially purified glycoprotein or, alternatively, the antibodies may be prepared ... Specifically, the glycoprotein and the isolated and purified antibody therefore can be used in the above-described method of ...
Goat Anti-Human Alpha 1 Acid Glycoprotein Polyclonal Antibody, Unconjugated from Immunology Consultants Laboratory, Inc.
Goat anti-Human Alpha 1 Acid Glycoprotein For Research and Manufacturing Only; Not for,biological,biology supply,biology ... Goat Anti-Human Alpha 1 Acid Glycoprotein Polyclonal Antibody, Unconjugated from Immunology Consultants Laboratory, Inc., ... Rabbit Anti-Human Rad51 Polyclonal Antibody, Unconjugated from Abcam. 11. Mouse Anti-Human RAD51L3 Monoclonal Antibody, ... 2ndGen Predilute antibody for staining tissue sections. Optimized for use with Zymeds Histostain-PLUS, NBA, HistoST5050, and ...
PRIME PubMed | Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a...
PubMed journal article Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a ... Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or ... Myelin Oligodendrocyte Glycoprotein Antibody-Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome. ... Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study.. J ...
Polyclonal AntibodyELISAPrimary antibodiesSpecificityEpitopesMouse monoclonal antibodyRecombinant antibodiesImmunogenBindsSerumMurine monoclonal antibodiesMajor zymogen granule membrane glycoproteinSurface glycoproteinCloneAntiphospholipid SyndromeMembrane glycoproteinsRecognizesWestern BlotEnvelope glycoproteinsAlpha-2 HS-GlycoproteinAssaysTumor-associated glycoproteinMabsConjugateSecondary AntibodiesPanel of monoclonal antibodiesMonoclonal antibody directedMultiple sclerosisTherapeutic AntibodiesBroadlyClinicalCharacterizationFlow cytometrySpike GlycoproteinEbolaPeptides
- The following product was used in this experiment: P-Glycoprotein Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-88245, RRID AB_2804771. (thermofisher.com)
- Goat Anti-Human Alpha 1 Acid Glycoprotein Polyclonal Antibody, Unconjugated from Immunology Consultants Laboratory, Inc. (bio-medicine.org)
- TPBG MaxPab rabbit polyclonal antibody. (acris-antibodies.com)
- Western Blot analysis of TPBG expression in transfected 293T cell line ( H00007162-T03 ) by TPBG MaxPab polyclonal antibody.Lane 1: TPBG transfected lysate(46.00 KDa).Lane 2: Non-transfected lysate. (acris-antibodies.com)
- We offer Heartland Virus Glycoprotein 1 Antibodies for use in common research applications: ELISA. (novusbio.com)
- Levels of anti-GP2 antibodies (IgA and IgG classes) have been detected by ELISA, employing recombinant human GP2 (Medipan GmbH, Germany). (bmj.com)
- Antibody‐secreting clones were found to be specific for Thy‐1 by enzyme‐linked immunosorbent assay (ELISA) and Western transfer and immunoblotting. (deepdyve.com)
- In additivity and competition ELISA, it was found that three of the antibodies bound to the same (or similar) epitopes, and three had different epitope specificities. (deepdyve.com)
- Eluted fractions containing anti-β2GPI antibodies were neutralised and analysed by ELISA using various binding buffers. (biomedcentral.com)
- Enzyme-linked immunosorbent assays (ELISA) are used for the detection of antibodies to the HSV-2 glycoprotein G-2 (gG-2) ( 3 ). (asm.org)
- If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
- Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
- There are 17 Ebola virus Glycoprotein antibodies which are validated in multiple tissues with various applications, including WB, ELISA. (sinobiological.com)
- There are 10 Ebola virus Glycoprotein antibody for WB, 13 Ebola virus Glycoprotein antibody for ELISA. (sinobiological.com)
- and 2) selection of an antibody with the specificity of said antibody of claim 1. (google.com)
- The present invention relates to monoclonal antibodies which have specificity for P-glycoprotein (Pgp). (google.com)
- The development by Kohler and Milstein (1) of somatic cell fusion techniques for the production of hybrid cell lines which produce monoclonal antibodies has made it possible to prepare unlimited quantities of homogeneous antibody products which have-defined specificity for single antigenic determinants. (google.com)
- See the supplier page to learn important antibody details, such as target specificity and designated applications. (biocompare.com)
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. (thermofisher.com)
- Specificity studies of the antibody and endosialidase treatment showed that the polysialic acid glycans detected were composed of chains as long as eight sialic acid residues or more. (jimmunol.org)
- Human recombinant antibodies or fragments thereof having specificity for the β2-glycoprotein I (β2GΡΙ), pharmaceutical compositions containing same and use thereof in a method for treating or preventing thrombus formation and fetal loss in a patient affected by antiphospholipid syndrome (APS). (wipo.int)
- To determine the in vivo specificity of the antibodies, passive transfer studies were performed with mice infected with the MP strain of HSV-1, a mutant of HSV-1 (mP) which is defective in the production of glycoprotein gC. (asm.org)
- However, the specificity of the neutralizing antibody response in natural HCV infection still is poorly understood. (semanticscholar.org)
- Nevertheless, antibody could bind to the virus at 37 degrees C, suggesting that the virus is in dynamic motion making hidden epitopes briefly available. (nih.gov)
- Comparison of our structure with that of a previously reported nAb complex (JUNV GP1-GD01) reveals largely overlapping epitopes but highly distinct antibody-binding modes. (rcsb.org)
- They found distinct abnormal mucin-type O-glycopeptide epitopes (parts of molecules that antibodies will recognize and bind to) that were targeted by autoantibodies in cancer patients - but such antibodies were absent in healthy controls. (highlighthealth.com)
- Currently there are no recombinant antibodies capable of binding gD epitopes for use in treating BoHV-1 infection. (ebscohost.com)
- Thus, immunization with oligomeric Env generates a large proportion of antibodies to conformational epitopes in both gp120 and gp41, many of which may be absent from monomeric Env. (asm.org)
- Having previously mapped seven major epitopes on platelet glycoprotein IIIa that are recognized by helper T cells from patients with immune thrombocytopenia, the aim was to test whether peptide therapy with any of these sequences, alone or in combination, could inhibit responses to the antigen in humanized mice expressing HLA-DR15. (haematologica.org)
- However, the combination of glycoprotein IIIa peptides aa6-20 and aa711-725, which contain the predominant helper epitopes in patients and elicited the strongest trends to suppress when used individually, did abrogate this response. (haematologica.org)
- Overall, these data demonstrate that combinations of peptides containing helper epitopes, such as platelet glycoprotein IIIa aa6-20 and aa711-725, can promote in vivo suppression of responses to the major antigen implicated in immune thrombocytopenia. (haematologica.org)
- Moreover, these bispecific antibodies are markedly more potent than their parental bNAbs, likely because they simultaneously engage both the apex and V3-glycan epitopes of Env. (asm.org)
- Our data show that simultaneous engagement of two critical epitopes of a single Env trimer can markedly increase the potency of a bispecific antibody. (asm.org)
- Here, we develop and characterize bispecific constructs based on well-characterized V2-glycan and V3-glycan bNAbs and show that at least one member of this class is more potent than its parental antibodies, indicating that they can simultaneously bind both of these epitopes of a single Env trimer. (asm.org)
- For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. (abgent.com)
Mouse monoclonal antibody3
- P Glycoprotein antibody LS-C16466 is an unconjugated mouse monoclonal antibody to human P Glycoprotein (ABCB1 / MDR1). (lsbio.com)
- HIV-1 Envelope Glycoprotein antibody LS-C535983 is an FITC-conjugated mouse monoclonal antibody to HIV-1 Envelope Glycoprotein from feline leukemia virus. (lsbio.com)
- Monoclonal antibody (MAb) 667 is a neutralizing mouse monoclonal antibody recognizing the envelope glycoprotein (Env) of the ecotropic neurotropic murine retrovirus CasBrE but not that of other murine retroviruses. (cnrs.fr)
- Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility. (abcam.com)
- Hudson, P. J. and Souriau, C. (2001) Recombinant antibodies for cancer diagnosis and therapy. (springer.com)
- In addition, the findings of this study constitute a warning against the direct use of hybridoma cell culture supernatants for studying the initial events of retroviral cell infection as well as for carrying out in vivo neutralization experiments and suggest that either recombinant antibodies or highly purified antibodies are preferable for these purposes. (cnrs.fr)
- To begin to explore the immunological properties of potential envelope-based subunit vaccine candidates, we have used a soluble recombinant surface glycoprotein (gp46, SU) fused to the Fc region of human IgG (sRgp46-Fc) as an immunogen to vaccinate mice. (jimmunol.org)
- Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
- This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
- The gp46 surface glycoprotein binds to cell surface receptors, including heparan sulfate proteoglycans, neuropilin 1, and glucose transporter 1, allowing the transmembrane glycoprotein to initiate fusion of the viral and cellular membranes. (jimmunol.org)
- Several bispecific antibodies have been developed to increase the breadth of these antibodies, but typically only one arm of these bispecific constructs binds the HIV-1 envelope glycoprotein trimer (Env). (asm.org)
- Each Fc region of a particular antibody isotype is able to bind to its specific Fc Receptor (except for IgD, which is essentially the BCR), thus allowing the antigen-antibody complex to mediate different roles depending on which FcR it binds. (wikipedia.org)
- Intended for the in vitro quantitative measurement of antibodies directed to β2-Glycoprotein I in human serum and plasma to aid in the diagnosis of antiphospholipid syndrome (APS) and to evaluate the thrombotic risk in patients with systemic lupus erythematosus (SLE). (fishersci.com)
- OBJECTIVE: To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals. (biomedsearch.com)
- PATIENTS: Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant MOG (rMOG) antibody determination. (biomedsearch.com)
- MAIN OUTCOME MEASURES: Serum and CSF rMOG antibody and albumin levels were used to calculate an rMOG index. (biomedsearch.com)
- Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. (unboundmedicine.com)
- Passive transfer of anti-mgG-2 monoclonal antibodies, or immune serum, to naive C57BL/6 mice did not limit disease progression. (mdpi.com)
- This virus exhibited resistance to several different neutralizing anti-gH murine monoclonal antibodies (MAbs), as well as to a polyvalent anti-gH serum. (asm.org)
- Zinc-alpha-2-glycoprotein (ZAG) is found in body fluids such as serum, sweat, and seminal and breast cyst fluids. (biovendor.com)
- Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype. (semanticscholar.org)
Murine monoclonal antibodies2
- Two murine monoclonal antibodies specific for human platelets were prepared and characterized by immunofluorescence, immunoprecipitation and by studying their effect on platelet function. (nih.gov)
- Five murine monoclonal antibodies (Mabs) reactive against the prM glycoproteins of DEN-3 and -4 were used to passively protect mice in vivo against lethal challenge with homologous and heterologous dengue virus serotypes. (ajtmh.org)
Major zymogen granule membrane glycoprotein1
- Molecular model of a surface glycoprotein from the Ebola virus (EBOV) bound to an antibody. (sciencephoto.com)
- A team of researchers have recently determined the crystal structure of the oligomeric, viral surface glycoprotein in complex with a rare antibody derived from a human survivor. (stanford.edu)
- Antiphospholipid antibodies most frequently develop in people with the autoimmune disorder called antiphospholipid syndrome (APS) . (labtestsonline.org)
- Isolated IgA Anti- β 2 Glycoprotein I Antibodies in Patients with Clinical Criteria for Antiphospholipid Syndrome," Journal of Immunology Research , vol. 2014, Article ID 704395, 8 pages, 2014. (hindawi.com)
- Seronegative antiphospholipid syndrome (SNAPS) is an autoimmune disease present in patients with clinical manifestations highly suggestive of Antiphospholipid Syndrome (APS) but with persistently negative consensus antiphospholipid antibodies (a-PL). IgA anti- β 2 Glycoprotein I (aB2-GPI) antibodies are associated with APS. (hindawi.com)
- Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly bind to beta 2-glycoprotein I (beta 2-GPI), which is adsorbed to an oxidized polystyrene surface. (rupress.org)
- A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome. (trieste.it)
- The antiphospholipid syndrome (APS) entails a prothrombotic state associated with the presence of anticardiolipin antibodies (aCL). (ovid.com)
- The 5E8 antibody and the M r 160,000 glycoprotein that it recognizes represent two very useful components with which to test several new antibody-mediated drug delivery systems in the treatment of human lung tumors. (aacrjournals.org)
- Recognizes human P-glycoprotein. (lsbio.com)
- The antibody recognizes a unique molecule of the pathogen, called an antigen, via the Fab's variable region. (wikipedia.org)
- Many of these agents are also enveloped viruses possessing important neutralizing determinants within their membrane-anchored envelope glycoproteins, and the use of recombinant, soluble versions of these viral glycoproteins is often critical in the isolation and development of antiviral hmAbs. (springer.com)
- Infection of human cells by human T cell leukemia virus type 1 (HTLV-1) is mediated by the viral envelope glycoproteins. (jimmunol.org)
- The envelope glycoproteins are recognized by neutralizing Abs and CTL following a protective immune response, and therefore, represent attractive components for a HTLV-1 vaccine. (jimmunol.org)
- Viruses pseudotyped with the crystallization construct plus the transmembrane domain are functional in infectivity assays and exhibit antibody neutralization profiles identical to wild-type GP. (stanford.edu)
- Glycoprotein G-based herpes simplex virus type 2 (HSV-2) enzyme-linked immunosorbent assays from Focus and Kalon were performed with specimens from 118 patients with culture-documented genital herpes episodes, and their results were compared. (asm.org)
- There are increasing concerns about the performance and accuracy of various commercially available serological assays for the detection of HSV-2 antibodies ( 4 , 9 ). (asm.org)
- Rapid membrane assays are used as point-of-care tests specific for HSV-2 antibodies to gG-2 ( 10 ). (asm.org)
- Western blotting (WB) and gG monoclonal antibody blocking assays are used as the "gold standard" for confirmation ( 12 ). (asm.org)
- Abgent offers single-use antibody panel for cost- and time-efficient screening assays. (abgent.com)
- Neutralization assays showed that mAb A6 lacks neutralizing capacity and does not interfere with the activity of known neutralizing antibodies. (nottingham.ac.uk)
- After washing away non-bound antibodies, enzyme-labeled antibodies against human IgG (IgM, IgA) antibodies (EliA IgG, IgM, IgA Conjugate ) are added to form an antibody-conjugate complex. (fishersci.com)
- CH129, with its restricted normal tissue distribution, avid tumor binding, and efficient payload delivery, is a promising candidate for the treatment of sialyl-di-Lewis a -expressing solid tumors, as an antibody-drug conjugate or as an alternative cancer immunotherapy modality. (aacrjournals.org)
Panel of monoclonal antibodies1
Monoclonal antibody directed1
- MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. (questdiagnostics.com)
- The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions. (questdiagnostics.com)
- Elevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis. (biomedsearch.com)
- Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis. (edu.au)
- To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. (rcsb.org)
- Broadly neutralizing antibodies (bNAbs) can prevent and control an HIV-1 infection, but their breadth is invariably too limited for use as monotherapy. (asm.org)
- IMPORTANCE Broadly neutralizing antibodies (bNAbs) can prevent a new HIV-1 infection and can at least temporarily suppress an established infection. (asm.org)
- The past decade has seen the emergence of a number of potent broadly neutralizing antibodies (bNAbs) that recognize nearly every available surface of the HIV-1 envelope glycoprotein (Env) ( 1 - 7 ). (asm.org)
- We have aimed to assess aPL antibodies in a group of patients with clinical manifestations of APS (C-APS) to evaluate the importance of the presence of IgA aB2GPI antibodies in APS and its relation with other aPL antibodies. (hindawi.com)
- The analysis of IgA aB2GPI antibodies in patients with clinical manifestations of PAPS might avoid underdiagnosed patients and provide a better diagnosis in patients with SAD-APS. (hindawi.com)
- Background We evaluated the seroprevalence of myelin oligodendrocyte glycoprotein immunoglobulin G1 (MOG-IgG) and associated clinical features of patients from a large adult-dominant unselected cohort with mainly relapsing central nervous system (CNS) inflammatory diseases. (bmj.com)
- To evaluate demographic, clinical and laboratory features associated with scleroderma-specific auto-antibodies. (ebscohost.com)
- Clinical Phenotypes of Patients with Anti-DFS70/LEDGF Antibodies in a Routine ANA Referral Cohort. (ebscohost.com)
- To analyze the clinical value of anti-DFS70 antibodies in a cohort of patients undergoing routine antinuclear antibodies (ANAs) testing. (ebscohost.com)
- These antibodies are frequently found in the plasma of patients with systemic lupus erythematosus (SLE)(3-5) and are reported to be associated with clinical events such as arterial and/or venous thrombosis, thrombocytopenia, and obstetric complications (6-12). (thefreelibrary.com)
- Background/aims To investigate the clinical features of Chinese patients with seropositive myelin oligodendrocyte glycoprotein antibody (MOG-Ab) optic neuritis (ON) and patients with seropositive aquaporin-4 antibody (AQP4-Ab) ON. (bmj.com)
- Broad Anti-Hepatitis C Virus (HCV) Antibody Responses Are Associated with Improved Clinical Disease Parameters in Chronic HCV Infection. (semanticscholar.org)
- In the absence of available vaccines or antiviral drugs for many important human viral pathogens, the identification and characterization of new human monoclonal antibodies (hmAbs) that are able to neutralize viruses offers the possibility for effective pre- and/or post-exposure therapeutic modalities. (springer.com)
- Isolation, partial characterization, and localization of a rat renal tubular glycoprotein antigen. (rupress.org)
- Characterization of hepatitis C virus E2 glycoprotein interaction with a putative cellular receptor, CD81. (semanticscholar.org)
- None of the individual peptides, delivered by a putative tolerogenic regimen, consistently suppressed the antibody response to subsequent immunization with human platelet glycoprotein IIb/IIIa. (haematologica.org)
- Suppression of antibody was associated with reduced splenocyte T-cell responsiveness to the antigen, and with the induction of a regulatory T-cell population that is more responsive to the peptides than to purified platelet glycoprotein IIb/IIIa. (haematologica.org)