The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.
Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Formation and development of a thrombus or blood clot in the blood vessel.
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
An acute or prolonged illness usually considered to be life-threatening or with the threat of serious residual disability. Treatment may be radical and is frequently costly.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Three or more consecutive spontaneous abortions.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
A systemic non-inflammatory arteriopathy primarily of middle-aged females characterized by the association of livedo reticularis, multiple thrombotic CEREBRAL INFARCTION; CORONARY DISEASE, and HYPERTENSION. Elevation of antiphospholipid antibody titers (see also ANTIPHOSPHOLIPID SYNDROME), cardiac valvulopathy, ISCHEMIC ATTACK, TRANSIENT; SEIZURES; DEMENTIA; and chronic ischemia of the extremities may also occur. Pathologic examination of affected arteries reveals non-inflammatory adventitial fibrosis, thrombosis, and changes in the media. (From Jablonski, Dictionary of Syndromes & Eponymic Diseases, 2d ed; Adams et al., Principles of Neurology, 6th ed, p861; Arch Neurol 1997 Jan;54(1):53-60)
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
Agents that prevent clotting.
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
Sites on an antigen that interact with specific antibodies.
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.
Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The asymmetrical segregation of genes during replication which leads to the production of non-reciprocal recombinant strands and the apparent conversion of one allele into another. Thus, e.g., the meiotic products of an Aa individual may be AAAa or aaaA instead of AAaa, i.e., the A allele has been converted into the a allele or vice versa.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Antibodies reactive with HIV ANTIGENS.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
The formation or presence of a blood clot (THROMBUS) within a vein.
Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.
Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
A subnormal level of BLOOD PLATELETS.
A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.
Constituent composed of protein and phospholipid that is widely distributed in many tissues. It serves as a cofactor with factor VIIa to activate factor X in the extrinsic pathway of blood coagulation.
Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.
Endogenous substances, usually proteins, that are involved in the blood coagulation process.
A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Benign DERMATOSIS caused by a loss of dermal ELASTIC TISSUE resulting in localized sac-like areas of flaccid skin. It can be either primary (idiopathic) or secondary to other skin conditions, PENICILLAMINE use, or premature birth.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A condition characterized by neck stiffness, headache, and other symptoms suggestive of meningeal irritation, but without actual inflammation of the meninges (MENINGITIS). Spinal fluid pressure may be elevated but spinal fluid is normal. (DeJong, The Neurologic Examination, 4th ed, p673)
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective antithrombotic agents. Their administration reduces the risk of hemorrhage, they have a longer half-life, and their platelet interactions are reduced in comparison to unfractionated heparin. They also provide an effective prophylaxis against postoperative major pulmonary embolism.
Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)
Inflammation of a vein associated with a blood clot (THROMBUS).
Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot.
Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6)
Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).
Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.
Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream.
Death and putrefaction of tissue usually due to a loss of blood supply.
Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Antimetabolites that are useful in cancer chemotherapy.
A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.
A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
Inflammation of the inner lining of the heart (ENDOCARDIUM), the continuous membrane lining the four chambers and HEART VALVES. It is often caused by microorganisms including bacteria, viruses, fungi, and rickettsiae. Left untreated, endocarditis can damage heart valves and become life-threatening.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
A condition that is caused by recurring atheroembolism in the lower extremities. It is characterized by cyanotic discoloration of the toes, usually the first, fourth, and fifth toes. Discoloration may extend to the lateral aspect of the foot. Despite the gangrene-like appearance, blue toes may respond to conservative therapy without amputation.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.
Proteins prepared by recombinant DNA technology.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Established cell cultures that have the potential to propagate indefinitely.
Antibodies obtained from a single clone of cells grown in mice or rats.
Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Formation of an infarct, which is NECROSIS in tissue due to local ISCHEMIA resulting from obstruction of BLOOD CIRCULATION, most commonly by a THROMBUS or EMBOLUS.
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.
Damages to the EMBRYO, MAMMALIAN or the FETUS before BIRTH. Damages can be caused by any factors including biological, chemical, or physical.
System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.
Reproduction of data in a new location or other destination, leaving the source data unchanged, although the physical form of the result may differ from that of the source.
Substances that are recognized by the immune system and induce an immune reaction.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Disorders or diseases associated with PUERPERIUM, the six-to-eight-week period immediately after PARTURITION in humans.
The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Substances elaborated by bacteria that have antigenic activity.
An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.

Antiphospholipid, anti-beta 2-glycoprotein-I and anti-oxidized-low-density-lipoprotein antibodies in antiphospholipid syndrome. (1/452)

Antiphospholipid antibodies (aPL), anti-beta 2-glycoprotein I (anti-beta 2-GPI) and anti-oxidized-low-density lipoprotein (LDL) antibodies are all implicated in the pathogenesis of antiphospholipid syndrome. To investigate whether different autoantibodies or combinations thereof produced distinct effects related to their antigenic specificities, we examined the frequencies of antiphospholipid syndrome (APS)-related features in the presence of different antibodies [aPL, beta 2-GPI, anti-oxidized low density lipoprotein (LDL)] in 125 patients with APS. Median follow-up was 72 months: 58 patients were diagnosed as primary APS and 67 as APS plus systemic lupus erythematosus (SLE). Anticardiolipin antibodies (aCL), anti-beta 2-GPI and anti-oxidized LDL antibodies were determined by ELISA; lupus anticoagulant (LA) by standard coagulometric methods. Univariate analysis showed that patients positive for anti-beta 2-GPI had a higher risk of recurrent thrombotic events (OR = 3.64, 95% CI, p = 0.01) and pregnancy loss (OR = 2.99, 95% CI, p = 0.004). Patients positive for anti-oxidized LDL antibodies had a 2.24-fold increase in the risk of arterial thrombosis (2.24, 95% CI, p = 0.03) and lower risk of thrombocytopenia (OR = 0.41 95% CI, p = 0.04). Patients positive for aCL antibodies had a higher risk of pregnancy loss (OR = 4.62 95% CI, p = 0.001). When these data were tested by multivariate logistic regression, the association between anti-beta 2-GPI and pregnancy loss and the negative association between anti-oxidized LDL antibodies and thrombocytopenia disappeared.  (+info)

Antibodies against phospholipids and oxidized LDL in alcoholic patients. (2/452)

Antiphospholipid antibodies (APA) are a generic term describing antibodies that recognize various phospholipids. Hepatocyte damage is a cardinal event in the course of alcoholic liver injury and autoantibodies against phospholipids could play an important role in this process. APA in alcoholic patients seem to reflect membrane lesions, impairment of immunological reactivity, liver disease progression and they correlate significantly with disease severity. LDL oxidation is supposed to be one of the most important pathogenic mechanisms of atherosclerosis and antibodies against oxidized low-density lipoprotein (oxLDL) are some kind of an epiphenomenon of this process. The scope of our study was to determine some autoantibodies (IgG-oxLDL and antiphospholipid antibodies) and their possible changes in alcoholic patients. We studied IgG-oxLDL and four APA - anticardiolipin antibodies (ACA), antiphosphatidylserine antibodies (APSA) antiphosphatidylethanolamine antibodies (APE) and antiphosphatidylcholine antibodies (APCA) in 35 alcoholic patients with mildly affected liver function at the beginning of the abuse treatment. The control group consisted of 60 healthy blood donors. In the studied group, we obtained positive results concerning total ACA in 17.1 % of alcoholic patients (8.3 % in the control group), 11.4 % IgG-ACA (6.7 %), 8.6 % IgM-ACA (3.3 %), 14.3 % total APE (6.7 %), 14.3 % total APCA (8.3 %) and 20 % total APSA (8.3 % in the control group). The IgG-oxLDL (406.4+/-52.5 vs 499.9+/-52.5 mU/ml) was not affected in alcoholic patients. We conclude that the autoantibodies against oxLDL are present in sera of alcoholics and healthy blood donors. Based on our results which revealed a wide range of IgG-oxLDL titres in the healthy population, this parameter does not appear to be very promising for the evaluation of the risk of atherosclerosis. Alcoholics with only mild affection of liver functions did not exhibit a significantly higher prevalence of all studied antiphospholipid antibodies (ACA, APSA, APE, APCA) which could lead to membrane lesions in these patients.  (+info)

The intrarenal vascular lesions associated with primary antiphospholipid syndrome. (3/452)

Even 10 yr after the identification of the antiphospholipid syndrome (APS), renal involvement in the course of APS is still relatively unrecognized, and is probably underestimated. The association of anticardiolipin antibodies and/or lupus anticoagulant with the development of a vaso-occlusive process involving numerous organs is now confirmed. In a multicenter study, 16 cases of "primary" APS (PAPS) were found and followed for 5 yr or more, all with renal biopsy. In all 16 cases of PAPS, there was a vascular nephropathy characterized by small vessel vaso-occlusive lesions associated with fibrous intimal hyperplasia of interlobular arteries (12 patients), recanalizing thrombi in arteries and arterioles (six patients), and focal cortical atrophy (10 patients). In combination, these led to progressive destruction of the kidney, accelerated by acute glomerular and arteriolar microangiopathy in five patients. Focal cortical atrophy is a distinctive lesion, present in 10 biopsies, and likely represents the histologic and functional renal analogue to the multiple cerebral infarcts detected on imaging studies. The clinical hallmark of this vascular nephropathy in PAPS is systemic hypertension, only variably associated with renal insufficiency, proteinuria, or hematuria. The ensemble of histologic renal lesions defined in this study should aid in the separation of the lesions found in cases of secondary APS, especially systemic lupus erythematosus, into those lesions related to APS and those related to the underlying disease.  (+info)

Factor V Leiden and antibodies against phospholipids and protein S in a young woman with recurrent thromboses and abortion. (4/452)

We describe the case of a 39-year-old woman who suffered two iliofemoral venous thromboses, a cerebral ischemic infarct and recurrent fetal loss. Initial studies showed high levels of antiphospholipid antibodies (APAs) and a moderate thrombocytopenia. After her second miscarriage, laboratory diagnosis revealed that the woman was heterozygous for the factor V Leiden mutation and had a functional protein S deficiency as well as anti-protein S and anti-beta 2-glycoprotein I antibodies. The impairment of the protein C pathway at various points could well explain the recurrent thromboses in the patient and supports the role of a disturbed protein C system in the pathophysiology of thrombosis in patients with APAs.  (+info)

Anti-phospholipid antibodies and CD5+ B cells in HIV infection. (5/452)

This cross-sectional study evaluates the correlation between anti-phospholipid antibodies and CD5+ B cells in 110 patients infected with HIV-1. There were 89.1% of the patients who had IgG antibodies against cardiolipin and phosphatidylserine. The prevalence of IgM and IgA antibodies was < 22%. AIDS was associated with lower frequencies of IgM antibodies against cardiolipin (P = 0.05) and IgG-antibodies against cardiolipin and phosphatidylserine (P = 0.011). Drug users had higher IgM antibodies against phospholipids than patients from other risk groups (P = 0.02). A history of thromboembolic events was not accompanied by higher levels of anti-phospholipid antibodies (P > 0.2). No correlation between anti-phospholipid antibodies and CD5+ B cells was detected. Percentage part of CD5+ B lymphocytes was elevated in all patients and absolute CD4+ T lymphocyte counts and HIV p24 antigen were inversely correlated. In advanced disease a significant reduction of anti-phospholipid antibodies was contrasted with persistent elevation of CD5+ B lymphocytes. These observations may reflect immunological dysfunction involving apoptosis and endothelial damage rather than polyclonal B cell hyperstimulation. A possible explanation would be that in HIV infection an increased rate of spontaneous apoptosis in peripheral blood lymphocytes is accompanied by functional and structural changes of mitochondria. Therefore, structurally altered mitochondrial phospholipids could serve as antigen to induce specific humoral immune responses.  (+info)

Antibodies to adult human endothelial cells cross-react with oxidized low-density lipoprotein and beta 2-glycoprotein I (beta 2-GPI) in systemic lupus erythematosus. (6/452)

Cardiovascular manifestations are common in systemic lupus erythematosus (SLE). Oxidized low-density lipoprotein (oxLDL) is implicated in cardiovascular disease, especially atherosclerosis, and cross-reacts with antibodies to cardiolipin (aCL). beta 2-GPI is a plasma protein participating in the coagulating cascade, and is also cofactor for aCL, and some aCL have been shown to be directed against beta 2-GPI and/or complexes between beta 2-GPI and phospholipids. Lysophosphatidylcholine (LPC) is a phospholipid present both in oxLDL and in damaged endothelium, and we recently showed that LPC is involved in the antigenicity of oxLDL. Antibodies to endothelial cells (aEC) correlate with diseases activity in SLE and vasculitis, and we recently showed that aEC are enhanced in cardiovascular disease such as borderline hypertension and early atherosclerosis. aEC were determined using EC from adult V. Saphena Magna. Antibody levels were determined by ELISA. aEC of IgG type were enhanced in 184 patients with SLE compared with 85 healthy controls. There was a close correlation between aoxLDL, aCL, aLPC, a beta 2-GPI and aEC. Binding of sera to EC was competitively inhibited by beta 2-GPI, LPC and oxLDL. Taken together, the data indicate that EC share antigenic epitopes with beta 2-GPI and with oxLDL, especially LPC. Phospholipids in EC membranes may thus be antigenic epitopes. beta 2-GPI may bind to these phospholipids, and become an autoantigen. LPC is formed by oxidation of phospholipids and/or proinflammatory factors leading to activation of phospholipase A2, and the findings indicate the potential role of both lipid oxidation and phospholipase A2 in SLE.  (+info)

The presence of infection-related antiphospholipid antibodies in infective endocarditis determines a major risk factor for embolic events. (7/452)

OBJECTIVES: The impact of infection-associated antiphospholipid antibodies (APA) on endothelial cell activation, blood coagulation and fibrinolysis was evaluated in patients with infective endocarditis with and without major embolic events. BACKGROUND: An embolic event is a common and severe complication of infective endocarditis. Despite the fact that APAs are known to be associated with infectious diseases, their pathogenic role in infective endocarditis has not been clearly defined. METHODS: The relationship among the occurrence of major embolic events, echocardiographic vegetation size, endothelial cell activation, thrombin generation, fibrinolysis and APA was examined in 91 patients with definite infective endocarditis, including 26 patients with embolic events and 65 control subjects without embolic events. RESULTS: Overall, 14.3% of patients exhibited elevated APA levels. Embolic events occurred more frequently in patients with elevated levels of APA than in patients without (61.5% vs. 23.1%; p = 0.008). Patients with elevated levels of APA showed higher levels of prothrombin-fragment F1 +2 (p = 0.005), plasminogen-activator inhibitor 1 (p = 0.0002), von Willebrand factor (p = 0.002) and lower levels of activated protein C (p = 0.001) than patients with normal levels of APA. Thrombin generation and endothelial cell activation were both positively correlated with levels of APA. The occurrence of elevated APA levels was frequently associated with structural valve abnormalities (p = 0.01) and vegetations >1.3 cm (p = 0.002). CONCLUSIONS: Infection-associated elevated APA levels in patients with infective endocarditis are related to endothelial cell activation, thrombin generation and impairment of fibrinolysis. This may contribute to the increased risk for major embolic events in these patients.  (+info)

Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. (8/452)

BACKGROUND: Antiphospholipid (aPL) antibodies are associated with thrombosis in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in vivo in mice, but the mechanism of thrombosis by aPL is not completely understood. Although aPL antibodies have been shown to inhibit protein C activation and activate endothelial cells (ECs) in vitro, no study has examined whether these antibodies activate ECs in vivo. Therefore, human affinity-purified aPL (ap aPL) antibodies from APS patients were tested in a mouse model of microcirculation using the cremaster muscle that allows direct microscopic examination of thrombus formation and adhesion of white blood cells (WBCs) to ECs as an indication of EC activation in vivo. Adhesion molecule expression on human umbilical vein endothelial cells (HUVECs) after aPL exposure was performed to confirm EC activation in vitro. METHODS AND RESULTS: All 6 ap aPL antibodies significantly increased the expression of VCAM-1 (2.3- to 4.4-fold), with one of the antibodies also increasing the expression of E-selectin (1.6-fold) on HUVECs in vitro. In the in vivo experiments, each ap aPL antibody except for 1 preparation increased WBC sticking (mean number of WBCs ranged from 22.7 to 50.6) compared with control (14.4), which correlated with enhanced thrombus formation (mean thrombus size ranged from 1098 to 6476 versus 594 microm2 for control). CONCLUSIONS: Activation of ECs by aPL antibodies in vivo may create a prothrombotic state on ECs, which may be the first pathophysiological event of thrombosis in APS.  (+info)

TY - JOUR. T1 - Antiphospholipid antibodies and retinal vascular disease. AU - Dunn, James P.. AU - Noorily, S. W.. AU - Petri, M.. AU - Finkelstein, D.. AU - Rosenbaum, J. T.. AU - Jabs, D. A.. PY - 1996. Y1 - 1996. N2 - Background. Antiphospholipid antibody retinopathy is a rare and poorly defined clinical entity in which the proper diagnosis has important ocular and systemic implications. The clinical course of five patients with antiphospholipid antibody retinopathy is described and the role of such antibodies in idiopathic retinal venous occlusive disease is investigated. Methods. Five case reports are presented highlighting the presentation, course, therapy, associations and outcomes of patients with antiphospholipid antibody retinopathy. In addition, twenty additional patients presenting with idiopathic retinal venous occlusive disease were tested for the presence of antiphospholipid antibodies. Results. All five patients with antiphospholipid antibody retinopathy had diffuse retinal ...
This page includes the following topics and synonyms: Antiphospholipid Antibody Test, aPL Antibody, Antiphospholipid Antibodies, Antiphospholipid Antibody, Anticardiolipin Antibody Test, Anticardiolipin Antibody.
Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated. Many connective tissue diseases such as rheumatoid arthritis are often associated with antiphospholipid antibodies-associated endothelial impairment. In the present study, the investigators will analyze the presence of antiphospholipid antibodies in the serum of the patients with gout/asymptomatic hyperuricemia, with a comparison to the patients of osteoarthritis but without hyperuricemia and gout. The investigators expect to find a correlation between these pathogenic antibody and those cardiovascular co-morbidities ...
TY - JOUR. T1 - Antiphospholipid antibodies and fetal loss. T2 - Clinical association and possible pathogenetic role in experimental models. AU - Meroni, P. L.. AU - Piona, A.. AU - La Rosa, L.. AU - Tincani, A.. AU - Balestrieri, G.. AU - Casali, P.. PY - 1995/1/1. Y1 - 1995/1/1. N2 - It is widely accepted that the persistent presence of antiphospholipid antibodies (aPL) represents a high risk factor for recurrent spontaneous abortion, fetal growth retardation, and complicated pregnancies (early and severe preeclampsia). However, whether aPL can be regarded as direct pathogenetic antibodies and which pathogenetic mechanism sustains the clinical manifestations are still open questions. We approached the problem by (a) setting up an experimental model of fatal loss in naive mice; and (b) by investigating the deposition of β2 glycoprotein I (β2 GPI)-the plasma cofactor for aPL-on placentae from women suffering from aPL-associated recurrent abortion. In the experimental model we found that ...
You may also need to take blood thinners for 3 to 4 weeks after surgery to lower your risk of blood clots.. ANTIPHOSPHOLIPID ANTIBODY SYNDROME (APS) In general, you will need long-term treatment with a blood thinner for a long time if you have the APS. Initial treatment may be heparin, either unfractionated or low-molecular heparin. These medicines are given by injection.. In most cases, warfarin (Coumadin), which is given by mouth, is then started. It is necessary to monitor the level of anticoagulation frequently. This is most often done using the INR test.. If you have APS and become pregnant, you will need to be followed closely by a provider expert in this condition. You will not take warfarin during pregnancy, but will be given low-molecular weight heparin instead.. If you have SLE and APS your provider will also recommend that you take hydroxychloroquine. ...
Antiphospholipid syndrome is a thrombotic disorder characterized by the association of arterial and venous thrombosis with the antibodies directed toward phospholipids. The presence of these antibodies in systemic lupus erythematosus(SLE) has been shown to be related to several clinical and analytical alterations. We experienced one case of lupus nephritis with positive antiphospholipid antibodies in a 10-year-old girl whose chief complaint was persistent microscopic hematuria. We report this case with a brief review of related literatures. (J. Korean Soc Pediatr Nephrol 2001 ;5 : 219-24) ...
Summary Antiphospholipid antibodies (APLA) have been shown to activate endothelial cells (EC) in vitro, as documented by an increased expression of tissue factor as well as leukocyte adhesion molecules such as intercellular adhesion molecule-1, vascular cell adhesion molecule (VCAM)-1 and E-selecti...
Antiphospholipid antibodies (aPL) have been reported in the cerebrospinal fluids (CSF) of neurology patients but no CSF studies with psychiatric patients exist. We tested serum from 100 hospitalized psychotic patients having hallucinations and/or delusions for aPL. Patients with positive serum aPL f …
Read Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia, Scientific Reports on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Antibodies directed toward phosphatidylethanolamine (anti-PE) appear to occur particularly frequently in women with unexplained early fetal loss (UFL). Two studies have shown that the presence of anti-PE antibodies is a higher independent risk factor for early UFL than either aCL or anti-β2GPI antibodies.22,23 Moreover, anti-PE antibodies have been reported as the only aPL antibodies found in cases of UFL (73%). Regarding thrombosis, which is the other main clinical feature of APS, a multicenter study conducted within the framework of the European Forum on aPL antibodies found the prevalence of anti-PE was 15% in patients with unexplained venous thrombosis; this specificity was found mainly as the sole aPL antibody.24 At present, there is no accepted standardized method for the measurement of anti-PE, and the heterogeneity of these antibodies increases the difficulties in attaining such a goal. This problem significantly limits the utility of this assay. Hence, following current evidence, the ...
Methods We identified all patients with ESRD at our center who had aPL Abs measured between 2005 and 2012. SLE was defined using ICD9 (International Classification of Disease) code (710.0). We also determined the prevalence of aPL Abs in a subgroup of patients who fulfilled the American College of Rheumatology criteria for SLE and had a history of biopsy proven lupus nephritis. IgA, IgG, and IgM isotypes were measured for the following aPL Abs: anticardiolipin (aCL), anti-beta2 glycoprotein I (anti-B2GPI), and antiphosphatidylserine (aPS). Positivity was defined as ≥20IU (laboratory criteria), and ≥40IU (clinical criteria). We used Fisher exact test to compare the frequencies of aPL Abs between non-SLE, SLE by ICD9 and SLE by ACR criteria vs. non-SLE.. ...
Antiphospholipid antibodies (APAs) are detected in various autoimmune diseases, such as antiphospholipid syndrome (APS) and systemic lupus erythematosus. In addition to their binding to negatively charged phospholipids, APAs often cross-react with other molecules. Their potential biological effects are not fully understood. Apoptotic cells are a potential source of auto-antigens during systemic autoimmunity. Inefficient clearance of apoptotic cells results in the development of autoimmune manifestations and intracellular antigens such as nucleosomes become accessible during apoptosis. We examined a panel of monoclonal APAs generated from NZW/BXSB F1, a strain which spontaneously develops autoimmune symptoms reminiscent of APS. These APAs did not bind to live cells, but reacted strongly with different structures within apoptotic cells. Further analysis with various inhibitors indicated that the binding of APAs to apoptotic cells depends on specific caspase activities and on the modification of ...
Results At least one EE was detected in 118 (63%) patients (52 cerebral, 95 other locations) after IE diagnosis in 80 (time interval between IE and EE diagnosis: 5.9±11.3 days). At least one aPL antibody was found in 31 patients (17%).. Detection of EE over time after IE diagnosis was more frequent among patients with anti-β2GPI IgM (log-rank P=0.0036) and that of cerebral embolisms, among patients with aCL IgM and anti-β2GPI IgM (log-rank P=0.002 and P,0.0001, respectively).. Factors predictive of EE were anti-β2GPI IgM (HR=3.45 (1.47-8.08), P=0.0045), creatinine (2.74 (1.55-4.84), P=0.0005) and vegetation size (2.41 (1.41-4.12), P=0.0014). Those of cerebral embolism were aCL IgM (2.84 (1.22-6.62), P=0.016) and anti-β2GPI IgM (4.77 (1.79-12.74), P=0.0018). ...
We report in Figure 2 the annual rate (∼ 0.4%) of first cardiovascular event (including VTE) in normal white population at 35 to 55 years of age,14 that (1.36%) of 125 single aPL positive carriers with a mean age of 41 years (data taken by a recently published study by our group),15 and that (5.3%) of triple-positive carriers of this study (mean age, 45 years). Annual rate in a cohort of SLE patients half of whom had aPL was 2.9 per 100 patient-years.16 Hence, because less than half of our cohort had autoimmune disorders, the higher incidence of TEs recorded in this study may be related to the selection of high-risk aPL-positive population. Likewise, in patients with APS and triple positivity,7 TEs were equally distributed among arterial and venous circulation. Some patients in this study were treated with aspirin for primary thromboprophylaxis, behavior that did not lead to a significant reduction of events. To our knowledge, only one prospective clinical trial addresses the question of ...
Am J Reprod Immunol. 2009 Aug;62(2):96-111. doi: 10.1111/j.1600-0897.2009.00717.x. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
We evaluated inter-assay variation in anticardiolipin antibody status, comparing three centres, and using different assays among 36 women with recurrent miscarriage and 26 controls. There was no more agreement between the laboratories than would be predicted on the basis of chance for IgM and only fair agreement among the laboratories for IgG. None of the tests were significantly more likely to be positive in the cases compared with the controls ...
ECAT Foundation , P.O. Box 107 , 2250 AC Voorschoten , The Netherlands , Email: [email protected] , T: +31 (0) 71 3030 910 , F: +31 (0) 71 3030 ...
This is a study about why some people have certain types of proteins in their blood, called anti-phospholipid antibodies. The presence of these antibodies and associated complications (e.g. blood clots) are known to change over time. The purpose of this study is to evaluate these changes and improve our ability to determine the long-term outcome of affected individuals ...
Anti-Phospholipid Laboratories manufactures the anti-phospholipid antibody reagents distributed by Genprice. The Anti-Phospholipid Antibody reagent is RUO (Research Use Only) to test human serum or cell…. ...
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The anti-phos-pho-lip-id syn-drome (APS) has -been asso-ciat-ed -with mul-ti-ple car-diac abnor-mal-ities. The -present -report -describes a -case of -right ven-tri-cle throm-bus in a 51--year-old wom-an -with a his-to-ry of auto-im-mune haem-o-lyt-ic ane-mia and anti-phos-pho-lip-id anti-bod-ies. Transthoracic ech-o-car-di-og-ra-phy dem-on-strat-ed the pres-ence of a -right ven-tri-cle -mass, mim-ick-ing a myx-o-ma. She under-went -open -heart remov-al of the -mass and was stard-ed on indef-i-nite-ly anti-co-ag-u-lant ther-a-py. At 2 -years fol-low-up she was -free of symp-toms.. ...
An examination of the symptoms, rupture of blood cells (fibrin production), liver damage, clotting (low serum heparin), high blood pressure (capillary apoptosis), proteinuria (low heparan sulfate (HS) to prevent protein loss), pointed to some obvious treatments and the causes. Infertility is often treated by in vitro fertilization/insemination, supported with aspirin and heparin injections to maintain gestation. These treatments are consistent with high levels of chronic inflammation that block implantation and stimulate labor. Infertility is also associated with antiphospholipid antibodies. A closer look at the antiphospholipid antibodies showed that they were directed against β2-glycoprotein-I. So, I expected the β2-glycoprotein-I protein to be the original target for the antibodies, the initiating antigen, but when I looked up the sequence of that protein, it lacked the expected basic triplet I have found in all other autoantigens and allergens. This meant to me that there was a different ...
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Health, ...For years researchers have known that antiphospholipid antibodies (aP... Based on the available data our best estimate is that around 10 to 1...The research will be presented on Nov. 13 at 3:15 p.m. ET during the...In some individuals aPLs do not cause any health problems but in oth...,Autoimmune,disease,linked,to,pregnancy,loss,,stroke,more,often,than,you d,expect,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
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TY - JOUR. T1 - Determination of non-bilayer phospholipid arrangements and their antibodies in placentae and sera of patients with hypertensive disorders of pregnancy. AU - Campos, Begona. AU - Chames, M.. AU - Lantry, J. M.. AU - Bill, J. P.. AU - Eis, A.. AU - Brockman, D.. AU - Neil, J.. AU - Tischner, E.. AU - Barton, J.. AU - Wong, C.. AU - Schwemberger, S.. AU - Cornelius, J.. AU - Myatt, L.. AU - Baeza, I.. AU - Hnat, M.. PY - 2006/2/1. Y1 - 2006/2/1. N2 - Studies suggest that preeclampsia (PE) originates in the placenta and is associated with deficient trophoblast invasion of spiral arteries. The direct cause remains unknown, but preeclampsia is often associated with circulating factors that can induce generalized endothelial dysfunction. Antiphospholipid antibodies (APA) in circulation are also associated with vascular diseases. Although the quantification of APA is not currently used as a prognostic of the risk of PE, studies suggest that thrombophilias play a role in PE pathogenesis. ...
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Question - Pregnant, US showed low lying posterior. History of miscarriage. Was positive for APTT and APLA, started Heparin. Ask a Doctor about diagnosis, treatment and medication for Thrombosis, Ask an OBGYN, Gynecologic Oncology
Antiphospholipid antibody syndrome: Find the most comprehensive real-world symptom and treatment data on antiphospholipid antibody syndrome at PatientsLikeMe. 640 patients with antiphospholipid antibody syndrome experience fatigue, Pain, depressed mood, anxious mood, and insomnia and use Aspirin, Hydroxychloroquine, Warfarin, Enoxaparin, and Oxycodone to treat their antiphospholipid antibody syndrome and its symptoms.
How is Seronegative Antiphospholipid Antibody Syndrome abbreviated? SNAPS stands for Seronegative Antiphospholipid Antibody Syndrome. SNAPS is defined as Seronegative Antiphospholipid Antibody Syndrome rarely.
Systemic Antiphospholipid Syndrome, Antiphospholipid Syndrome information and help pages for APS patients, doctors and medical professionals Antiphospholipid Syndrome - Systemic Antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with typical laboratory abnormalities. These include persistently elevated levels of antibodies directed against membrane anionic phospholipids (ie, anticardiolipin [aCL] antibody, antiphosphatidylserine) or their associated plasma proteins, predominantly beta-2 glycoprotein I (apolipoprotein H), or evidence of a circulating anticoagulant.Multiple terms exist for APS. Unfortunately, some synonyms can be confusing. Lupus anticoagulant (LA) syndrome, for example, is misleading because patients may not ... Antiphospholipid Syndrome - Antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with typical laboratory
Systemic Antiphospholipid Syndrome, Antiphospholipid Syndrome information and help pages for APS patients, doctors and medical professionals Antiphospholipid Syndrome - Systemic Antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with typical laboratory abnormalities. These include persistently elevated levels of antibodies directed against membrane anionic phospholipids (ie, anticardiolipin [aCL] antibody, antiphosphatidylserine) or their associated plasma proteins, predominantly beta-2 glycoprotein I (apolipoprotein H), or evidence of a circulating anticoagulant.Multiple terms exist for APS. Unfortunately, some synonyms can be confusing. Lupus anticoagulant (LA) syndrome, for example, is misleading because patients may not ... Antiphospholipid Syndrome - Antiphospholipid syndrome (APS) is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with typical laboratory
Donadini, MP, Crowther, M. Antiphospholipid syndrome: a challenging hypercoagulable state with systemic manifestations. Hematol-Oncol. vol. 24. 2010. pp. 669-76. (Recent concise review and update of this syndrome. Many of the clinical statistics were cited from this review.). Ruiz-Irastorza, G, Crowther, M, Branch, W, Khamashta, MA. Antiphospholipid syndrome. Lancet. vol. 376. 2010. pp. 1498-1509. (Along with the first listed reference, a key source for this chapter, especially with respect to treatment recommendations.). Frances, C. Dermatological manifestations of Hughes antiphospholipid antibody syndrome. Lupus. vol. 19. 2010. pp. 1071-77. (Current review of cutaneous manifestations.). Weinstein, S, Piette, W. Cutaneous manifestations of antiphospholipid antibody syndrome. Hematol Oncol Clinics N Am. vol. 22. 2008. pp. 67-77. (Relatively recent review of cutaneous findings.). Hughes, GRV. Antiphospholipid syndrome (Hughes syndrome): 10 clinical topics. Lupus. vol. 19. 2010. pp. ...
Antiphospholipid Antibody Syndrome (APS) is a highly prevalent cause of antibody-mediated thrombosis manifesting in venous thrombosis (DVT and PE), arterial thrombosis (most commonly stroke), and pregnancy complications. The diagnosis of definite APS requires both clinical and laboratory criterion as established by the working group of the International Congress on Antiphospholipid Antibodies (based on expert opinion). Since thrombosis and pregnancy loss are common in the general population, and antiphospholipid antibodies (aPL) occurs in a small percentage of the healthy public, it is important to demonstrate antibody persistence in patients who have the proper clinical indications in order to avoid misdiagnosis. Unfortunately, laboratory testing in this area lacks standardization, resulting in wide inter-laboratory variance. However, due to the commercialization of tests and automation, inter-laboratory variance has improved. Data on several new non-criterion tests suggest that they may ...
Antiphospholipid antibody syndrome is a fascinatingly complex disorder. It is an autoimmune disease, whereby the immune system attacks our own tissues. This article summarises the basic mechanisms of the condition and main diseases it is involved in. Learn about the diverse effects antiphospholipid antibody syndrome (APS) can have, from heart attack to miscarriage and how APS can be treated.
Antiphospholipid syndrome is an autoimmune disease, in which antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common in women than in men. The exact cause is not known, but activation of the system of coagulation is evident. Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease state) forms. Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by degradating activated factor V). Lupus anticoagulant (LAC) antibodies bind to prothrombin, thus increasing its cleavage to thrombin, its active ...
New life-saving treatments for Antiphospholipid syndrome in clinical trial on Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome
Sources Used in Current Review. Berg, T. (Updated 2015 April 15). Antiphospholipid syndrome and pregnancy. Medscape. Available online at http://emedicine.medscape.com/article/261691-overview. Accessed 2/15/2017.. (Reviewed 2016 March 21). Antiphospholipid syndrome. Lupus Foundation of America. Available online at http://www.lupus.org/answers/entry/antiphospholipid-syndrome. Accessed 2/15/2017.. Movva, S. (Updated 2016 July 1). Antiphospholipid syndrome workup. Medscape. Available online at http://emedicine.medscape.com/article/333221-workup. Accessed 2/15/2017.. Moake, J. (Revised 2016 September) Antiphospholipid antibody syndrome. Merck Manual Professional Version. Available online at http://www.merckmanuals.com/professional/hematology-and-oncology/thrombotic-disorders/antiphospholipid-antibody-syndrome-aps. Accessed 2/15/2017.. (Updated 2016 December). Antiphospholipid syndrome - APS. ARUP. Available online at http://www.arupconsult.com/Topics/APS.html?client_ID=LTD. Accessed 2/15/2017.. (© ...
TY - JOUR. T1 - IgG/IgM antiphospholipid antibodies present in the classification criteria for the antiphospholipid syndrome: a critical review of their association with thrombosis. AU - Kelchtermans, H.. AU - Pelkmans, L.. AU - de Laat, B.. AU - Devreese, K. M.. PY - 2016/8. Y1 - 2016/8. KW - anti-cardiolipin. KW - anti-phospholipid antibody. KW - antiphospholipid syndrome. KW - (2)-glycoprotein I. KW - IgM. U2 - 10.1111/jth.13379. DO - 10.1111/jth.13379. M3 - Article. VL - 14. SP - 1530. EP - 1548. JO - Journal of Thrombosis and Haemostasis. JF - Journal of Thrombosis and Haemostasis. SN - 1538-7933. IS - 8. ER - ...
TY - JOUR. T1 - De novo infantile primary antiphospholipid antibody syndrome. AU - Alshekaili, J.. AU - Reynolds, G.. AU - Cook, M. C.. PY - 2010/11. Y1 - 2010/11. N2 - Most autoimmune diseases are rare in infants. Early onset can represent an extreme phenotype arising from strong genetic predisposition relatively independent of environmental influence. Alternatively, neonatal autoimmunity can arise from transplacental passage of maternal pathogenic IgG autoantibodies. Distinguishing between these possible explanations is crucial for determining the prognosis in the specific patient, and has important implications for understanding pathogenesis. We report a case of neonatal thrombotic stroke associated with both cardiolipin and β2-glycoprotein I antibodies in neonatal serum but absent from cord blood and maternal serum. While the child also carried one prothrombotic allele of factor V (Leiden allele), which may have contributed to the risk of thromboembolic disease, the serological analysis ...
Antiphospholipid antibodies occur in various clinical states, including the primary antiphospholipid syndrome. Clinical features in these conditions appear to be caused by vasculopathy associated with the presence of these antibodies.. We report the case of a patient with primary antiphospholipid syndrome who experienced cardiac necrosis secondary to myocardial microvasculopathy in the absence of vasculitis. This case demonstrates unequivocally that noninflammatory myocardial microvasculopathy occurs in the primary antiphospholipid syndrome per se without any clinical or immunologic signs of systemic lupus erythematosus or other disease process. The histopathologic findings in the skin and myocardial biopsies showed a noninflammatory vasculopathy characterized by bland thrombi and lack of infiltration of the vessel wall by inflammatory cells. Ultrastructural examination of the myocardial biopsy confirmed the vascular thrombosis and endothelial activation and showed no deposits in basement ...
Objective: To investigate the prevalence and clinical correlates of anti-heparin platelet factor 4 antibodies (anti-HPF4) in SLE patients with and without antiphospholipid antibodies (aPL).. Methods: Sera and clinical data were obtained from the Hospital for Special Surgery Autoimmune Disease Registry for 78 aPL-positive and 91 aPL-negative SLE patients without heparin-induced thrombocytopenia (HIT). Controls were 90 blood donors of comparable age and sex. Sera were assayed for anti-HPF4, IgG/IgM antiphospholipid antibodies (APhL), and IgG/IgM-β2-glycoprotein 1 antibodies (anti-β2GP1). Serotonin release assays (SRAs) were performed for subjects with positive anti-HPF4.. Results: Positive anti-HPF4 was seen in 9% of aPL-positive SLE patients, 4% of aPL-negative SLE patients and 1% of controls (p-value = 0.026, aPL-positive SLE versus controls). Two of 12 subjects with positive anti-HPF4 had reactive SRAs. In SLE patients, anti-HPF4 significantly correlated with IgM APhL, IgM anti-β2GP1, and ...
Women with antiphospholipid antibodies (aPL) are at risk of adverse pregnancy outcomes, including recurrent first-trimester pregnancy loss and late pregnancy complications such as preeclampsia, HELLP (hemolysis, elevated liver enzyme levels, and low platelet levels) syndrome, premature delivery, intrauterine growth restriction, placental abruption, and intrauterine death. Current standard care in obstetric antiphospholipid syndrome includes aspirin and heparin and has resulted in live-birth rates of approximately 70%. However, 30% continue to have pregnancy complications. Hydroxychloroquine (HCQ) is suggested as a new treatment approach, but no randomized controlled trials (RCTs) have assessed its efficacy. This study aims to assess pregnancy outcome in women with aPL treated with HCQ versus placebo in addition to standard treatment. The HYdroxychloroquine to improve Pregnancy outcome in women with AnTIphospholipid Antibodies (HYPATIA) study is a phase IV multicenter RCT, in which pregnant women ...
TY - JOUR. T1 - Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome. T2 - Results of an international multicentre study. AU - Amengual, O.. AU - Forastiero, R.. AU - Sugiura-Ogasawara, M.. AU - Otomo, K.. AU - Oku, K.. AU - Favas, C.. AU - Delgado Alves, J.. AU - Žigon, P.. AU - Ambrožič, A.. AU - Tomšič, M.. AU - Ruiz-Arruza, I.. AU - Ruiz-Irastorza, G.. AU - Bertolaccini, M. L.. AU - Norman, G. L.. AU - Shums, Z.. AU - Arai, J.. AU - Murashima, A.. AU - Tebo, A. E.. AU - Gerosa, M.. AU - Meroni, P. L.. AU - Rodriguez-Pintó, I.. AU - Cervera, R.. AU - Swadzba, J.. AU - Musial, J.. AU - Atsumi, T.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Objective A task force of scientists at the International Congress on Antiphospholipid Antibodies recognized that phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) might contribute to a better identification of antiphospholipid syndrome (APS). Accordingly, initial and ...
TY - JOUR. T1 - Use of fondaparinux in a patient with antiphospholipid antibody syndrome and heparin-associated thrombocytopenia [9]. AU - Holtan, Shernan G.. AU - Knox, S. K.. AU - Tefferi, Ayalew. PY - 2006/7. Y1 - 2006/7. UR - http://www.scopus.com/inward/record.url?scp=33745225893&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33745225893&partnerID=8YFLogxK. U2 - 10.1111/j.1538-7836.2006.01961.x. DO - 10.1111/j.1538-7836.2006.01961.x. M3 - Article. C2 - 16839370. AN - SCOPUS:33745225893. VL - 4. SP - 1632. EP - 1634. JO - Journal of Thrombosis and Haemostasis. JF - Journal of Thrombosis and Haemostasis. SN - 1538-7933. IS - 7. ER - ...
The Antiphospholipid Antibody Syndrome Market is expected to grow at a CAGR of 8.31% and is poised to reach US$XX Billion by 2027 as compared to US$XX
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The antiphospholipid syndrome (APS) is characterised by the presence of antiphospholipid antibodies (aPA) associated with thrombosis (arterial and venous) and pregnancy morbidity. This thesis has aimed to investigate the frequency of protein C pathway defects in patients with aPA and to study clinical correlates examine the mechanisms of antiphospholipid interference in the protein C pathway and to assess activated protein C (APC) resistance in patients with aPA in terms of thrombin generation. Although have I have discovered a high degree of heterogeneity in the phenotype of patients with APS, I have demonstrated APC resistance and increased thrombin generation in the majority of patients with APS. While in some cases, APC resistance is clearly immunoglobulin mediated, it is a multifactorial phenomenon with many confounding variables. My data suggest that immunoglobulin dependent APC resistance may occur through P2 glycoprotein-I dependent and independent mechanisms. In a detailed study of ...
BACKGROUND Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by vascular thrombosis (arterial or venous) and/or pregnancy complications associated with the occurrence of autoantibodies, specifically lupus anticoagulant, anticardiolipin antibodies, and/or anti-β2 glycoprotein-I antibodies confirmed at least twice over a 12 week period according to the 2006 Sydney criteria. Antiphospholipid antibodies are encountered in the general population with a reported prevalence of 1% to 5% However, APS is far more infrequent with a prevalence of 40-50/100,000 persons and an incidence of about 5 new patients/100,000 persons. APS can be diagnosed in patients with no apparent clinical or laboratory pathology (primary APS) or it may be related to numerous other conditions, autoimmune diseases (usually systemic lupus erythematosus), malignancies, infections and drugs (secondary APS). Women are at risk for APS since the disease is encountered in both the primary and the secondary state
TY - JOUR. T1 - Thrombosis and thrombocytopenia in antiphospholipid syndrome (idiopathic and secondary to SLE). T2 - First report from the Italian Registry. AU - Barbui, T.. AU - Finazzi, G.. AU - Galli, M.. AU - Ciavarella, N.. AU - Schiavoni, M.. AU - Palareti, G.. AU - Marongiu, F.. AU - Muleo, G.. AU - Ferrari, L.. AU - Testa, S.. AU - Ballerini, G.. AU - Rossi Ferrini, P. L.. AU - Damasio, E.. AU - Trotta, A.. AU - Baudo, F.. AU - Pogliani, E.. AU - Rossi, E.. AU - DAngelo, A.. PY - 1993. Y1 - 1993. KW - antiphospholipid antibodies. KW - antiphospholipid syndrome. KW - Registry. KW - thrombocytopenia. KW - thrombosis. UR - http://www.scopus.com/inward/record.url?scp=0027515801&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0027515801&partnerID=8YFLogxK. M3 - Article. C2 - 8314161. AN - SCOPUS:0027515801. VL - 78. SP - 313. EP - 318. JO - Haematologica. JF - Haematologica. SN - 0390-6078. IS - 5. ER - ...
A 48-year-old woman with antiphospholipid syndrome (APS) had multiple skin necrosis caused by massive bleeding and hematoma collection at the right lower leg, left thigh, and abdomen. During the first month, we did surgical debridement every 2 to 3 days with meticulous coagulation and applied negative pressure wound therapy (NPWT). See the original post ...
BACKGROUND AND OBJECTIVES:. Vascular disease is common in systemic lupus erythematosus (SLE) and patients with antiphospholipid antibodies (aPL) are at high risk to develop arterial and venous thrombosis. Since HLA class II genotypes have been linked to the presence of pro-thrombotic aPL, we investigated the relationship between HLA-DRB1 alleles, aPL and vascular events in SLE patients.. METHODS:. 665 SLE patients of Caucasian origin and 1403 controls were included. Previous manifestations of ischaemic heart disease, ischaemic cerebrovascular disease (ICVD) and venous thromboembolism (together referred to as any vascular events (AVE)) were tabulated. aPL were measured with ELISA. Two-digit HLA-DRB1 typing was performed by sequence-specific primer-PCR.. RESULTS: HLA-DRB1*04 was more frequent among SLE patients with ICVD compared to unaffected patients. This association remained after adjustment for known traditional cardiovascular risk factors. HLA-DRB1*13 was associated with AVE. All measured ...
Splanchnic vein thrombosis (SVT) refers to Budd-Chiari syndrome (BCS) and portal vein system thrombosis (PVST). Current practice guidelines have recommended the routine screening for antiphospholipid antibodies (APAs) in patients with SVT. A systematic review and meta-analysis of observational studies was performed to explore the association between APAs and SVT. The PubMed, EMBASE, and ScienceDirect databases were searched for all relevant papers, in which the prevalence of positive APAs or levels of APAs should be compared between BCS or noncirrhotic PVST patients versus healthy controls, or between cirrhotic patients with portal vein thrombosis (PVT) versus those without PVT. Fourteen studies were eligible. Only 1 study evaluated the role of APAs in BCS patients and found that positive immunoglobulin (Ig) G anticardiolipin antibody (aCL) was more frequently observed in BCS patients than in healthy controls; however, the associations of other APAs with BCS were not evaluated. Positive IgG aCL ...
The objective of this study was to highlight the need for investigation of antiphospholipid (aPL) antibodies in patients presenting with myocardial infarction (MI) and normal coronary arteries at angiography. We present five patients who were found to have had an MI without evidence of atherosclerosis. All had aPL antibodies and thus fulfilled the diagnosis of antiphospholipid syndrome (APS). Who did not have recurrent events on long-term anticoagulation maintaining an international normalised ratio of 3-4. This study suggests that APS is probably a major cause of MI in those with normal coronary arteries at angiography. It is an important diagnosis to make as they do not require anti-atherosclerotic treatment but appear, from this case series, to do well on high-dose warfarin. Further clinical studies are necessary to look at prevalence and best management in these patients.
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Glomerular microthrombosis (GMT) is a common vascular change in patients with lupus nephritis (LN). The mechanism underlying GMT is largely unknown. Although several studies have reported the association of antiphospholipid antibodies (aPL) with GMT, the relation between GMT and aPL remains controversial. Previous studies have demonstrated that some aPL could bind to several hemostatic and fibrinolytic proteases that share homologous enzymatic domains. Of the protease-reactive aPL, some can inhibit the anticoagulant activity of activated protein C and the fibrinolytic function of plasmin, and hinder the antithrombin inactivation of thrombin. The purpose of this study was to investigate the prevalence of GMT in LN patients and examine the relation between the aPL profiles (including some protease-reactive aPL) and GMT. Renal biopsy specimens were examined for the presence of glomerular microthrombi. Plasma samples from 25 LN patients with GMT (LN-GMT group) and 99 LN patients without GMT (LN-non-GMT
Definition of antiphospholipid antibodies. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein 1 antibodies. APS can present with a variety of clinical phenotypes, including thrombosis in the veins, arteries and microvasculature as well as obstetrical complications. The pathophysiological hallmark is thrombosis, but other factors such as complement activation might be important. Prevention of thrombotic manifestations associated with APS includes lifestyle changes and, in individuals at high risk, low-dose aspirin. Prevention and treatment of thrombotic events are dependent mainly on the use of vitamin K antagonists. Immunosuppression and anticomplement therapy have been used anecdotally but have not been adequately tested. Pregnancy morbidity includes unexplained recurrent early miscarriage, fetal death and late obstetrical manifestation such as pre-eclampsia, premature birth or fetal ...
The present report describes three young women aged 25, 20 and 15 years who presented with Bells palsy. Two of the patients had a past history of the disease, which responded to steroid treatment. All three patients were positive for antiphospholipid antibody (APLA). In addition, one of the patients tested positive for antinuclear antibodies; however, there was no clinical evidence of systemic lupus erythematosus. All three patients responded well to steroid therapy. We conclude that Bells palsy may be one of the manifestations of APLA syndrome, and thus, APLA testing should be done in such cases.. Keywords: antiphospholipid antibody, APLA syndrome, autoimmune neuropathy, Bells palsy, facial ...
Fingerprint Dive into the research topics of Antiphospholipid antibody syndrome mimicking multiple sclerosis clinically and by magnetic resonance imaging. Together they form a unique fingerprint. ...
By Kristin Bendikson, MD. When a woman has a miscarriage, she often feels isolated and alone. Miscarriages are more common than most people realize, however; and when women start talking with their friends, they often find that they are not alone in coping with this difficult experience.. A miscarriage-the early loss of a pregnancy-occurs in approximately 15 percent of all clinically recognized pregnancies. If all pregnancies are accounted for, the statistic is closer to 50 percent ending in a loss. The increase is due to the fact that many women dont even know they are pregnant and experience their period at the normal time or just a few days late. Sometimes a woman knows she is having a miscarriage because she has symptoms, which might include bleeding and cramping followed by the passage of the pregnancy. Other times a woman doesnt sense there is anything wrong at all, and she finds out that the pregnancy has stopped growing only when she sees her doctor for an ultrasound.. Its important ...
By restricting our analyses to studies examining risk factors determined in early pregnancy, we focused on risk factors that could lead to a timely intervention, such as aspirin prophylaxis, write the authors in their discussion. We generated reliable and consistent results across studies, as most were completed in the past two decades within Western countries, and about two-thirds used a standard clinical definition of pre-eclampsia. This was evidenced by a 2.7% weighted mean event rate for all risk factors across all unexposed groups, a figure close to that estimated within Western countries.. The review identified 92 large sample cohort studies that included data from more than 25 million women. The investigators focused their efforts on determining the contributions of 14 common clinical risk factors for the development of preeclampsia. They calculated the pooled relative risk of developing preeclampsia in the presence or absence of each risk factor. They also calculated the pooled ...
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Antiphospholipid syndrome is a systemic autoimmune disorder. It is usually defined as the clinical complex of vascular occlusion and ischemic events occurring in patients who have circulating antiphospholipid antibodies. Clinical presentation A...
Antiphospholipid syndrome is a systemic autoimmune disorder. It is usually defined as the clinical complex of vascular occlusion and ischaemic events occurring in patients who have circulating antiphospholipid antibodies. Pathology Patients hav...
The Antiphospholipid Syndrome (APS) is characterized by thrombosis and pregnancy loss, clinical events mediated by pathogenic anti-phospholipid autoantibodies (aPL). β2-glycoprotein I (β2GPI) is the major autoantigens recognized by aPL. β2GPI is a cationic protein that binds to negatively charged surfaces such as those of apoptotic cells. This feature may lead to two major events: i) immunization with β2GPI fosters the Fc-receptor-mediated uptake by antigen presenting cells of apoptotic material decorated with β2GPIand the activation ofβ2GPI-specific T cells which in turn provide help to β2GPI-specific B cells for the production of anti-β2GPI; ii) apoptotic bodies decorated with β2GPI can be opsonized by anti-β2GPI and shifted towards a pro-inflammatory clearance by macrophages; epitope spread can occur with the generation of autoimmunity against nuclear autoantigens. In the presence of a predisposing genetic background and of a particular cytokine environment (type I interferons), the ...
Antiphospholipid syndrome (APS) is characterized by thromboses in the larger arteries and veins and thrombotic microangiopathy. Indications: Suspicion of antiphospholipid syndrome. Thromboembolism in ...
A look at antiphospholipid antibody syndrome, what laboratory tests can support the diagnosis of this syndrome, what are the causes and how is it treated. ...
Antiphospholipid antibodies (aPL) are associated with the recurrent pregnancy loss and thrombosis that characterizes the antiphospholipid antibody syndrome (APS). confirmed the pathogenicity of E7080 antibodies induced in TIFI-immunized mice [101C103]. Further supporting evidence for molecular mimicry as a possible mechanism for APS development was provided by a study evaluating the APS-related pathogenic potential of microorganisms carrying sequences related to a hexapeptide, TLRVYK, regarded as identified by a pathogenic monoclonal anti-2GPI Ab [104] specifically. Pursuing immunization with or tetanus toxoid; high titers of antibodies with anti-peptide (TLRVYK) and anti-2GPI activity had been seen in BALB/c mice. These affinity-purified antibodies were infused into naive mice at day time 0 of pregnancy then. At day time 15, these mice got significant thrombocytopenia, long term activated incomplete thromboplastin moments (aPTT) and improved rate of recurrence of fetal reduction compared to ...
Pathogenic and Therapeutic Role of Vitamin D in Antiphospholipid Syndrome Patients By Svetlana Jelic, Dejan Nikolic, Dragomir Marisavljević and Ljudmila Stojanovich Submitted: November 5th 2015Reviewed: August 2nd 2016 Published: April 26th 2017 DOI: 10.5772/65071 Abstract In this chapter, the novel findings on interrelationship between vitamin D status and two well‐known prothrombotic states, antiphospholipid syndrome, particularly its thrombotic phenotype, and metabolic syndrome will be reviewed. We shall present the results obtained from patients included in Serbian National Antiphospholipid Syndrome Registry, 68 patients with primary antiphospholipid syndrome (PAPS) and 69 patients with antiphospholipid syndrome associated with certain autoimmune rheumatic disease (sAPS), as well as 50 patients with pure metabolic syndrome (MetS). These results will be analysed and compared with the novel literature data. Prevalence of MetS in APS is high, with the atherogenic dyslipidaemia as its most ...
A woman in her thirties suffered from lupus and antiphospholipid antibody syndrome (APS), an autoimmune, hypercoagulable disorder caused by antiphospholipid antibodies, which attack and damage tissues and cells and cause blood clots to form in the bodys arteries and veins. The woman took several anticoagulant medications as a result of a stroke she suffered at age 20. She suffered another stroke and was admitted to the hospital. She was treated at the hospital for approximately three months. About a month into her stay she underwent a kidney biopsy. After the kidney biopsy she was again administered blood-thinning therapy, including the medication Lovenox. Several days after the kidney biopsy, the woman suffered a large hemorrhage from the area of the biopsy kidney, which had become infected. As a result, the woman developed renal and respiratory failure, multiple abscesses, aspiration pneumonia, and other serious injuries and complications for which she continues to require inpatient treatment years
The classical clinical picture of the antiphospholipid syndrome (APS) is characterized by venous and arterial thromboses, fetal losses and thrombocytopenia, in the presence of antiphospholipid...
... syndrome Polycythemia Hypercoagulability Protein C deficiency Antiphospholipid antibodies Anticardiolipin antibodies Lupus ... "Amaurosis fugax associated with antiphospholipid antibodies". Annals of Neurology. 25 (3): 228-32. doi:10.1002/ana.410250304. ... "Transient visual symptoms in systemic lupus erythematosus and antiphospholipid syndrome". Ocul. Immunol. Inflamm. 9 (1): 49-57 ...
"11 Pulmonary Hypertension and Antiphospholipid Antibodies". In Munther A Khamashta (ed.). Hughes Syndrome: Antiphospholipid ...
"Genome-wide association study of antiphospholipid antibodies". Autoimmune Diseases. 2013: 761046. doi:10.1155/2013/761046. PMC ...
Human parvovirus B19 infection and antiphospholipid antibodies, 2006 G. Siegl and P. Cassinotti, Parvoviruses Chapter 14, ... Human parvovirus B19 infection and antiphospholipid antibodies , 2006. "Other Types of Arthritis". Arthritis Action UK. ... VP1-proteins are incorporated into the capsid structure in a non-stoichiometrical relation (based on antibody-binding analysis ... Individuals with B19 IgG antibodies are generally considered immune to recurrent infection, but reinfection is possible in a ...
Abnormalities associated with antiphospholipid antibody syndrome include a paradoxical prolonged partial thromboplastin time ( ... Ünlü, O; Zuily, S; Erkan, D (2016). "The clinical significance of antiphospholipid antibodies in systemic lupus erythematosus ... People with SLE may have an association with antiphospholipid antibody syndrome (a thrombotic disorder), wherein autoantibodies ... Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE ...
They include acquired antibodies to coagulation factors, termed inhibitors of coagulation. The main inhibitor is directed ... Another example is antiphospholipid syndrome, an autoimmune, hypercoagulable state.[citation needed] Bleeding diathesis may ...
Annese V, Tomietto P, Venturini P, D'Agostini S, Ferraccioli G (2006). "[Migraine in SLE: role of antiphospholipid antibodies ... headaches in SLE and associated Raynaud's phenomenon and/or anti-cardiolipin antibodies. Further studies are needed however to ...
"Anticoagulation Management in a Patient With Antiphospholipid Antibodies Requiring Repeat Sternotomy". J Cardiothorac Vasc ...
Santilli, Daniele (2003). "Autosplenectomy and Antiphospholipid Antibodies in Systemic Lupus Erythematosus: A Pathogenic ...
Antiphospholipid antibody syndrome. altered coagulation. [14] Factor V Leiden defect. altered coagulation. [14] ...
... and many research papers on the antiphospholipid antibody syndrome. He convened the first International Conference on Pregnancy ... He is a researcher of autoimmune diseases, with focus on antiphospholipid syndrome and lupus. He is currently Professor of ... Lockshin's long-term research interest is in the clinical aspects of systemic lupus erythematosus (SLE), antiphospholipid ...
Antiphospholipid syndrome was described in full in the 1980s, after various previous reports of specific antibodies in people ... The risk is determined by the subtype of antibody detected, by the antibody titer (amount of antibodies), whether multiple ... Antiphospholipid antibodies are detected in 24% of those referred to thrombophilia testing. German physician Rudolf Virchow ... A prominent example is antiphospholipid syndrome, which is caused by antibodies against constituents of the cell membrane, ...
... antiphospholipid, and anticardiolipin antibodies.[citation needed] The erythrocyte sedimentation rate and C reactive protein ...
"Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies". Blood. 101 (9): ...
About 40-60% of patients with the syndrome test positive for antiphospholipid antibodies. Sneddon's patients are generally ... Sneddon's Syndrome was formerly understood to be a type of autoimmune disease called antiphospholipid syndrome, although it has ...
Islam, Md Asiful (2020). "Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis ... A meta-analysis published in 2020 identified that the prevalence of antiphospholipid antibodies including anticardiolipin (Odds ... The anti-HSP60 and anti-HSP65 antibodies that target HSPs produced by Streptococci (including S. sanguinis and S. pyogenes) and ... Tanaka, T.; Yamakawa, N.; Koike, N.; Suzuki, J.; Mizuno, F.; Usui, M. (June 1999). "Behçet's disease and antibody titers to ...
These antibodies are seen in 90% of SLE patients with psychosis. Antiphospholipid antibodies. The two antibodies implicated are ... Anti-neuronal antibodies. The three identified anti-neuronal antibodies postulated in CNS involvement are the lympho-cytotoxic ... These antibodies also correlate with cognitive and visual spatial defects. Second, the anti-neuronal membrane antibodies are ... CS1 maint: discouraged parameter (link) "Antiphospholipid Antibodies". Retrieved 2010-04-20. CS1 maint: discouraged parameter ( ...
A disruption in normal immune function can lead to the formation of antiphospholipid antibody syndrome. This will affect the ...
Around 15% of the women who have recurrent miscarriages have high levels of antiphospholipid antibodies. Women who have had ... may have their blood tested for antibodies, to determine if they have antiphospholipid syndrome. Women diagnosed with ... "Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant". The Cochrane Database of ... The antiphospholipid syndrome is an autoimmune disease that is a common cause of recurrent pregnancy loss. ...
Such as juvenile diabetes mellitus, antiphospholipid antibody-associated clotting disorders, collagen-vascular disease, and ...
Immunologic disorder: Positive anti-Smith, anti-ds DNA, antiphospholipid antibody, or false positive serological test for ... People with SLE may have an association with antiphospholipid antibody syndrome[22] (a thrombotic disorder), wherein ... Abnormalities associated with antiphospholipid antibody syndrome include a paradoxical prolonged partial thromboplastin time ( ... Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE ...
... some reports point out a second kind of CRION due to anti-phospholipid antibodies (anti-PL) Diagnosis requires exclusion of ... "Chronic relapsing inflammatory optic neuropathy in a patient with triple antiphospholipid antibody positivity". Neurological ... ANA, B12, folate, thyroid function tests, anti-aquaporin 4 antibodies (NMO-IgG), and GFAP can facilitate ruling out of other ... Anti-MOG antibodies are frequently associated with steroid-sensitive recurrent optic neuritis, Neurol Neuroimmunol Neuroinflamm ...
Current evidence suggests that the risk of recurrent thrombosis in patients with an antiphospholipid antibody is enhanced ... "Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant" (PDF). The Cochrane ... lupus anticoagulant is generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and ... In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of ...
Development of antibodies against β2-GP1 can lead to Antiphospholipid syndrome which often leads to pregnancy complications. ... McNeil HP, Simpson RJ, Chesterman CN, Krilis SA (1990). "Anti-phospholipid antibodies are directed against a complex antigen ... "Role of beta 2-glycoprotein I and anti-phospholipid antibodies in activation of protein C in vitro". J. Clin. Pathol. 46 (10): ... Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune antiphospholipid syndrome requires the presence ...
2014). Diagnostic performance study of an antigen microarray for the detection of antiphospholipid antibodies in human serum. ... antibodies. Binding of specific ligands to the immobilised receptor molecules results in a change refractive index n and ...
In the antiphospholipid antibody syndrome, the formation of the shield is disrupted by antibodies. Without the shield, there is ... Antibodies directed against annexin A5 are found in patients with a disease called the antiphospholipid syndrome (APS), a ... speeding up coagulation reactions and causing the blood-clotting characteristic of the antiphospholipid antibody syndrome. ...
The anti-β2GPI antibodies are most prevalent in causing the symptoms of the disease. When bound by an antibody, β2GPI begins to ... Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis and complications during pregnancy, often ... There is also speculation that the antibody/β2GPI complexes sensitize other cell types through various LDL family receptors to ... de Groot PG, Derksen RH (August 2005). "Pathophysiology of the antiphospholipid syndrome". J. Thromb. Haemost. 3 (8): 1854-60. ...
Acute multi-organ failure associated with antiphospholipid antibodies: A review of 31 patients". Lupus. 5 (5): 414-7. doi: ... Triplett, Douglas A.; Asherson, Ronald A. (2000). "Pathophysiology of the catastrophic antiphospholipid syndrome (CAPS)". ... Asherson, RA; Piette, JC (1996). "The catastrophic antiphospholipid syndrome 1996: ... other than Antiphospholipid syndrome) Treatment for Thrombotic Storm may include lifelong anticoagulation therapy and/or ...
Syphilis non-specific antibodies (reagin, see RPR) react with the lipid - the Wassermann reaction of antiphospholipid ... The antibody test was developed by Wassermann, Julius Citron, and Albert Neisser at the Robert Koch Institute for Infectious ... The Wassermann test or Wassermann reaction (WR) is an antibody test for syphilis, named after the bacteriologist August Paul ... antibodies (APAs). The intensity of the reaction (classed 1, 2, 3, or 4) indicates the severity of the condition. The reaction ...
"A STAT4 risk allele is associated with ischaemic cerebrovascular events and anti-phospholipid antibodies in systemic lupus ...
... is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and ... Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused ... Rand JH (1998). "Antiphospholipid antibody syndrome: new insights on thrombogenic mechanisms". The American Journal of the ... The presence of antiphospholipid antibodies (aPL) in the absence of blood clots or pregnancy-related complications does not ...
... and many of those have other antibodies (such as anti-phospholipid antibodies, anti-Ro, anti-SSA) or their ANA converted from ... anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to ... This pattern is associated with anti-dsDNA antibodies, antibodies to nucleosomal components, and anti-histone antibodies. There ... antibodies are antibodies to components of the nuclear membrane and are found in primary biliary cirrhosis (PBC). Each antibody ...
". "One of the most common tests looks for antinuclear antibodies (ANA), and antibodies to double-stranded DNA (which makes up ... Antiphospholipid syndrom. *Evt. Vascular Instability Syndrome. *Evt. Idiopatisk trombocytopeni (ITP). *Evt. Hæmolytisk anæmi ... ". "One of the most common tests looks for antinuclear antibodies (ANA), and antibodies to double-stranded DNA (which makes up ... because most XL-CGD carrier females who have been tested for lupus do not have the auto-antibodies used to diagnose lupus or, ...
Antiphospholipid antibody syndrome (APS or APLS). *Behcet syndrome. *Chronic inflammatory demyelinating polyneuropathy ... Antibodies. Donors are sometimes immunized against agents such as tetanus or hepatitis B so that their plasma contains the ... In other donors, an intentionally incompatible unit of blood is transfused to produce antibodies to the antigens on the red ... is also maintained by the PPTA for use in keeping donors with prior positive viral antibody test results from donating at any ...
antiphospholipid antibody (especially lupus anticoagulant, which paradoxically increases propensity to thrombosis). * ... antiphospholipid antibodies or coagulation factor specific inhibitors), while if it does disappear a factor deficiency is more ... presence of antibodies against coagulation factors (factor inhibitors). To distinguish the above causes, mixing tests are ...
... mimetic[edit]. Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens. They are ... Asymmetrical antibodies[edit]. Heterodimeric antibodies, which are also asymmetrical and antibodies, allow for greater ... How Lymphocytes Produce Antibody from Cells Alive!. *Antibody applications Fluorescent antibody image library, University of ... Nucleic acids and small molecules are sometimes considered antibody mimetics, but not artificial antibodies, antibody fragments ...
Idarucizumab is a monoclonal antibody, approved by the US FDA in 2015, that reverses effect of dabigatran by binding to both ... "Purple toes syndrome associated with warfarin therapy in a patient with antiphospholipid syndrome". Pharmacotherapy. 23 (5): ... Pathogenesis of immune-mediated HIT is believed to be caused by heparin-dependent immunoglobulin antibodies binding to platelet ...
Heparin can also cause a prothrombotic condition, heparin-induced thrombocytopenia (an antibody-mediated decrease in platelet ... Warfarin is also used in antiphospholipid syndrome. It has been used occasionally after heart attacks (myocardial infarctions ... "Purple toes syndrome associated with warfarin therapy in a patient with antiphospholipid syndrome". Pharmacotherapy. 23 (5): ...
Approximately only 0.1 to 0.5 percent of the general population has the antibody.[citation needed] ... Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55-63. doi:10.1080/ ... Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC ... Franceschini, F.; Cavazzana, I. (2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55-63. doi:10.1080/ ...
... antiphospholipid antibody syndrome, and those with history of pre-eclampsia. *Dietary factors, e.g. calcium supplementation in ... antiphospholipid syndrome and hemolytic-uremic syndrome. It must be considered a possibility in any pregnant woman beyond 20 ...
Various rare diseases involving prothrombin have been described (e.g., hypoprothrombinemia). Anti-prothrombin antibodies in ... autoimmune disease may be a factor in the formation of the lupus anticoagulant also known as (antiphospholipid syndrome). ...
The IgG antibodies form a complex with heparin and PF4 in the bloodstream. The tail of the antibody then binds to the FcγIIa ... "Platelet-endothelial interactions: sepsis, HIT, and antiphospholipid syndrome". Hematology Am Soc Hematol Educ Program. 2003 ... In HIT, the immune system forms antibodies against heparin when it is bound to a protein called platelet factor 4 (PF4). These ... Heparin occurs naturally in the human body, but the development of HIT antibodies suggests heparin may act as a hapten, and ...
Annese V, Tomietto P, Venturini P, D'Agostini S, Ferraccioli G (2006). "[Migraine in SLE: role of antiphospholipid antibodies ...
... antiphospholipid antibodies, D-dimer, genetic tests (e.g. factor V Leiden, prothrombin mutation G20210A), dilute Russell's ... antiphospholipid syndrome, factor V Leiden, and various other genetic deficiencies or variants).[medical citation needed] ...
One therapeutic conundrum is the development of inhibitor antibodies against factor VIII due to frequent infusions. These ... can be infused as a treatment for haemorrhage in individuals with haemophilia and antibodies against replacement factor VIII.[4 ...
Nomenclature of monoclonal antibodies (talk), GA1 - review started 10/02/2011. *Azathioprine (talk), GA1 - review started 31/08 ... Alkaptonuria (got onto DYK), Allergy, Alternating hemiplegia of childhood, Anaphylaxis (T), Anemia, Antiphospholipid syndrome, ... Diagnostic tests - Anti-citrullinated protein antibody, Blood culture, CA19-9, Cardiotocography, D-dimer, Endoscopic retrograde ... Anti-neutrophil cytoplasmic antibody, Antithrombin, C1-inhibitor, Cancer procoagulant, Cholesterylester transfer protein, ...
... is used together with heparin in pregnant women with antiphospholipid antibodies.[66] Additionally, indomethacin is used in ... Cervera R, Balasch J (2004). "The management of pregnant patients with antiphospholipid syndrome". Lupus. 13 (9): 683-7. doi: ...
... antiphospholipid antibody syndrome, and drug toxicities, e.g. calcineurin inhibitor toxicity.[1] ... antibodies, and drugs; and congenital predisposing conditions, including decreased levels of tissue factors necessary for the ...
... the presence of anti-phospholipid antibodies, and antinuclear antibodies. Anti-phospholipid antibodies are targeted toward the ... These antibodies also jeopardize the health of the uterus by altering the blood flow to the uterus. Antinuclear antibodies ... Both the presence of anti-phospholipids antibodies and antinuclear antibodies have toxic effects on the implantation of embryos ... Rh disease is caused by the mother producing antibodies (including IgG antibodies) against the Rhesus D antigen on her baby's ...
Antinuclear antibody reflexive panel, rheumatoid factor, and antiphospholipid antibodies are tests that may assist in the ... Takayasu's arteritis, polyarteritis nodosa, Behçet's disease, antiphospholipid syndrome. Vestibular disease. Posterior ... Patients often have cartilage-specific antibodies present during acute relapsing polychondritis episodes. ... Antiphospholipid syndrome,[5] Autoimmune hemolytic anemia,[5] Hashimoto's thyroiditis.[15] ...
The most recent form of organic childbearing psychosis to be described is encephalitis associated with antibodies to the NMDA ... it still occurs as a result of systemic lupus or anti-phospholipid syndromes. Only about 50 chorea psychoses have been reported ...
JD Alves; EL Radway-Bright; S Lee; B Grima; J Hothersall; CT Ravirajan; DA Isenberg (2005). "Antiphospholipid antibodies are ...
The case-control PAROKRANK study identified a strong association between an anticardiolipin antibody and MI, but also raises a ... Because antiphospholipid antibodies (aPLs) can come and go or increase and decrease, "it could be that the antibodies are a ... Cite this: Antiphospholipid Antibody Linked to First MI - Medscape - Oct 23, 2018. ... Those results showed that patients with MI had antibodies to fewer domains, mainly domains IV and V, while antibodies from ...
Definition of antiphospholipid antibodies. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and ... antiphospholipid antibodies. Definition: antibodies directed against phosphorylated polysaccharide esters of fatty acids, ... includes lupus anticoagulant, Venereal Disease Research Laboratories, and anticardiolipin antibodies. Associated with immune- ...
Antiphospholipid antibodies are autoantibodies that increase the risk of blood clots. Blood tests detect these autoantibodies ... and an asymptomatic elderly person who has developed an antiphospholipid antibody.. Transient antiphospholipid antibodies may ... Antiphospholipid antibodies are a group of immune proteins (antibodies) that the body mistakenly produces against itself in an ... People who have one or more antiphospholipid antibodies and those that are diagnosed with antiphospholipid syndrome can have an ...
... and an asymptomatic elderly person who has developed an antiphospholipid antibody.. Transient antiphospholipid antibodies may ... Antiphospholipid antibodies are a group of immune proteins (antibodies) that the body mistakenly produces against itself in an ... People who have one or more antiphospholipid antibodies and those that are diagnosed with antiphospholipid syndrome can have an ... Petri, M. (2001). Antiphospholipid Antibodies: Anticardiolipin Antibodies and the Lupus Anticoagulant in Systemic Lupus ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ... Anti-Phospholipid Antibodies. 2. Anti-Phospholipid Syndrome. 3. Anti-Phospholipid Antibody, IgM. 4. Adenovirus Antibody, IgG. 5 ... Anti-Centromere Antibody, IgG. 9. Anti-dsDNA Antibody, IgG. 10. Anti-GBM Antibody, IgA (IFA). 11. Anti-GBM Antibody, IgG (IFA) ... Adenovirus Antibody, IgM. 6. Anti-Cardiolipin Antibody, IgG. 7. Anti-Cardiolipin Antibody, IgM. 8. ...
... is a blood-clotting disorder that makes the blood clot ... Antiphospholipid antibody syndrome is caused by antibodies. The body normally makes antibodies that attack a dangerous ... A person who has these antibodies and has had blood clots is said to have antiphospholipid antibody syndrome. ... Antiphospholipid antibodies can be detected with a blood test. When diagnosed, this condition is usually treated with blood- ...
... , including how long the results take, specimen requirements and who to contact if you have a ... Home Our services Haemostasis and thrombosis centre Diagnostic haemostasis laboratories Antiphospholipid antibody markers ... IgG, IgM & IgA Anticardiolipin antibodies.. (IgG and IgM anti-beta2-glycoprotein 1 antibodies are available by special ... Antiphospholipid markers are available during routine hours. Requests for urgent results or tests out of routine hours must be ...
... , aPL Antibody, Antiphospholipid Antibodies, Antiphospholipid Antibody, Anticardiolipin Antibody ... Antiphospholipid Antibody Test, aPL Antibody, Antiphospholipid Antibodies, Antiphospholipid Antibody, Anticardiolipin Antibody ...
Antiphospholipid antibody synonyms, Antiphospholipid antibody pronunciation, Antiphospholipid antibody translation, English ... dictionary definition of Antiphospholipid antibody. abbreviation for Associate of the Institute of Chartered Accountants ... Related to Antiphospholipid antibody: Antiphospholipid antibody syndrome. ACA. abbreviation for (Accounting & Book-keeping) ... Dissolution of intracardiac mass lesions in the primary antiphospholipid antibody syndrome.. A case report of antiphospholipid ...
... antibodies are group of antibodies directed against epitopes on plasma proteins that are uncovered by binding of these proteins ... The most commonly used tests to detect APL include lupus anticoagulant (LAC), anticardiolipin (ACL) antibodies, and anti-β2 - ... encoded search term (Antiphospholipid Antibodies) and Antiphospholipid Antibodies What to Read Next on Medscape ... Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies. ...
... Milo Careaga,1,2 Robin L. Hansen,2,3 Irva Hertz-Piccotto,2 ... Anti-phospholipid antibodies are believed to occur from both genetic and environmental factors and have been linked to a number ... In the current study, we investigated whether there were elevated levels of anti-phospholipid antibodies in a cross-sectional ... This study provides the first evidence for elevated production of anti-phospholipid antibodies in young children with ASD and ...
Read our Antiphospholipid antibody syndrome encyclopedia resources online. ... Antiphospholipid antibody syndrome. Antiphospholipid antibody syndrome is a blood-clotting disorder that makes the blood clot ... Antiphospholipid antibody syndrome is caused by antibodies. The body normally makes antibodies that attack a dangerous ... A person who has these antibodies and has had blood clots is said to have antiphospholipid antibody syndrome. ...
Thrombosis in the antiphospholipid-antibody syndrome. [N Engl J Med. 1995]. *Answers to the antiphospholipid-antibody syndrome? ... Thrombosis in the antiphospholipid-antibody syndrome. [N Engl J Med. 1995]. *Thrombosis in the antiphospholipid-antibody ... Thrombosis in the antiphospholipid-antibody syndrome. [N Engl J Med. 1995]. *Thrombosis in the antiphospholipid-antibody ... The management of thrombosis in the antiphospholipid-antibody syndrome.. Khamashta MA1, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ ...
We evaluated inter-assay variation in anticardiolipin antibody status, comparing three centres, and using different assays ...
... and what the results of antiphospholipid antibody testing might mean ... Describes how antiphospholipid antibody tests are used, when they are requested, ... Antiphospholipid antibody testing is used to help determine the cause of:. Antiphospholipid antibody testing is used to help ... The most common antiphospholipid antibodies are cardiolipin antibodies (also called anticardiolipin antibodies or ACA) and the ...
Antiphospholipid Antibody Syndrome answers are found in the 5-Minute Clinical Consult powered by Unbound Medicine. Available ... Antiphospholipid Antibody Syndrome is a topic covered in the 5-Minute Clinical Consult. To view the entire topic, please log in ... Antiphospholipid Antibody Syndrome. In: Domino FJF, Baldor RAR, Golding JJ, et al, eds. 5-Minute Clinical Consult. Wolters ... "Antiphospholipid Antibody Syndrome." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2020. 5minute, www.unboundmedicine. ...
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary. ...
APLA stands for Antiphospholipid Antibody (syndrome). APLA is defined as Antiphospholipid Antibody (syndrome) frequently. ... Lupus anticoagulant, antiphospholipid syndrome and cardiac surgery. Antiphospholipid antibody syndrome manifesting as a deep ... Antiphospholipid antibody levels of Henoch-Schonlein purpura patients and controls HSP HSP Control active remission (n=30) ... The antiphospholipid antibody syndrome (APLS) is the most important treatable cause for recurrent miscarriage. ...
Graves Disease Associated with Cerebrovascular Disease and Antiphospholipid Antibody Syndrome. Ines Khochtali,1 Nadia Hamza,1 ... in this paper, we describe the case of a patient with Graves disease, who developed strokes with antiphospholipid antibodies ... which are favoured by a simultaneous presence of antiphospholipid antibodies syndrome. ...
Antiphospholipid Antibodies and Fetal Growth Restriction Official Title Antiphospholipid Antibodies and Early Fetal Growth ... Antiphospholipid Antibodies and Fetal Growth Restriction. The safety and scientific validity of this study is the ... The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane ... antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and obstetric complications ( ...
PubMed journal article Calciphylaxis in catastrophic antiphospholipid antibody syndrom were found in PRIME PubMed. Download ... "Calciphylaxis in Catastrophic Antiphospholipid Antibody Syndrome." Blood Coagulation & Fibrinolysis : an International Journal ... Calciphylaxis in catastrophic antiphospholipid antibody syndrome.. Blood Coagul Fibrinolysis 2015; 26(4):467-8BC ... Shah S, Larson A, Datta Y. Calciphylaxis in Catastrophic Antiphospholipid Antibody Syndrome. Blood Coagul Fibrinolysis. 2015;26 ...
SNAPS stands for Seronegative Antiphospholipid Antibody Syndrome. SNAPS is defined as Seronegative Antiphospholipid Antibody ... www.acronymfinder.com/Seronegative-Antiphospholipid-Antibody-Syndrome-(SNAPS).html. *Chicago style: Acronym Finder. S.v. "SNAPS ... www.acronymfinder.com/Seronegative-Antiphospholipid-Antibody-Syndrome-(SNAPS).html,SNAPS,/a,. ... www.acronymfinder.com/Seronegative-Antiphospholipid-Antibody-Syndrome-(SNAPS).html ...
... are a type of antibody directed against phospholipids. apls are present in up to 60% of people with lupus. ... What is an antiphospholipid antibodies test for lupus?. ANSWER An antiphospholipid antibodies test can help confirm a diagnosis ...
Antiphospholipid Antibodies and Early Severe Preeclampsia.. The safety and scientific validity of this study is the ... The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane ... Antiphospholipid Antibodies and Early Severe Preeclampsia (, 34 Weeks of Gestation). A Case-Control Study.. ... antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and obstetric complications ( ...
Explains a type of fertility test that can identify antibodies that lead to blood clots, which can endanger the life of both ... Types of Antiphospholipid Antibodies. There are 21 different types of antiphospholipid antibodies. All are tested in the ... Infertility and Antiphospholipid Antibody. High levels of antiphospholipid antibody are often associated with unexplained ... What are Antiphospholipid Antibodies (APA)?. Antibodies are special cells that are supposed to help our bodies attack foreign ...
Thermo Scientific Phadia 2-Glycoprotein I Antibodies for Antiphospholipid Syndrome EliA Beta2-Glycoprotein I IgA; Equivocal: 7 ... After washing away non-bound antibodies, enzyme-labeled antibodies against human IgG (IgM, IgA) antibodies (EliA IgG, IgM, IgA ... Thermo Scientific Phadia β 2-Glycoprotein I Antibodies for Antiphospholipid Syndrome Intended for the in vitro quantitative ... measurement of antibodies directed to β2-Glycoprotein I in human serum and plasma to aid in the diagnosis of antiphospholipid ...
Coagulopathy and antiphospholipid antibodies were seen in all three patients. ... Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19 N Engl J Med. 2020 Apr 23;382(17):e38. doi: 10.1056/ ...
640 patients with antiphospholipid antibody syndrome experience fatigue, Pain, depressed mood, anxious mood, and insomnia and ... Find the most comprehensive real-world symptom and treatment data on antiphospholipid antibody syndrome at PatientsLikeMe. ... and Oxycodone to treat their antiphospholipid antibody syndrome and its symptoms. ... What is antiphospholipid antibody syndrome?. Antiphospholipid syndrome, Hughes syndrome, or antiphospholipid antibody syndrome ...
Update on Antiphospholipid Antibody Syndrome Management , IntechOpen, Published on: 2012-04-20. Authors: Rocco Manganelli, ... Update on Antiphospholipid Antibody Syndrome Management. By Rocco Manganelli, Salvatore Iannaccone, Serena Manganelli and Mario ... Medicine » Immunology, Allergology and Rheumatology » Antiphospholipid Syndrome, book edited by Alena Bulikova, ISBN 978-953- ...
Effect of belimumab treatment on antiphospholipid antibody levels: post-hoc analysis based on two randomised placebo-controlled ... Management of antiphospholipid syndrome Imad Uthman, Mohammad Hassan A Noureldine, Guillermo Ruiz-Irastorza, Munther Khamashta ... EULAR recommendations for the management of antiphospholipid syndrome in adults Maria G Tektonidou, Laura Andreoli, Marteen ... but not in antiphospholipid syndrome Lucas L van den Hoogen, Maarten van der Linden, Linde Meyaard, Ruth D E Fritsch-Stork, ...
  • 2018;132:1365-1371 ) in high-risk APS patients triple-positive for lupus anticoagulant, anticardiolipin, and anti-β 2 GPI antibodies was terminated prematurely because of excess arterial events with rivaroxaban compared with warfarin (12% vs 0%), she noted. (medscape.com)
  • antibodies directed against phosphorylated polysaccharide esters of fatty acids, includes lupus anticoagulant, Venereal Disease Research Laboratories, and anticardiolipin antibodies. (drugs.com)
  • The 14th International Congress on Antiphospholipid Antibodies Task Force criteria for identifying APS requires testing for cardiolipin antibodies, lupus anticoagulant, and beta-2 glycoprotein antibodies when one of two clinical problems exist, blood clots (thrombosis) or pregnancy morbidity. (labcorp.com)
  • This preliminary proposal requires 4 manifestations, including at least 1 of 11 clinical manifestations and at least 1 of 6 immunologic manifestations (antinuclear antibody, anti-DNA, anti-Sm, antiphospholipid antibody , low complement, direct Coombs test), or lupus nephritis with positivity in either an antinuclear antibody or anti-DNA test. (thefreedictionary.com)
  • The most commonly used tests to detect APL include lupus anticoagulant (LAC), anticardiolipin (ACL) antibodies, and anti-β 2 -glycoprotein I antibodies. (medscape.com)
  • Antiphospholipid antibodies are frequently seen with autoimmune disorders such as Systemic Lupus Erythematosus (SLE) . (labtestsonline.org.uk)
  • Antiphospholipid antibody syndrome (APS) is a systemic autoantibody-mediated thrombophilic disorder characterized by recurrent arterial or venous thrombosis and/or recurrent fetal loss in the presence of persistent antiphospholipid antibodies (APAs) as evidenced by lupus anticoagulant (LAC), anticardiolipin antibodies (aCL), and/or anti- β 2 glycoprotein-I (GPI) antibody. (unboundmedicine.com)
  • Predictive value of persistent versus transient antiphospholipid antibody subtypes for the risk of thrombotic events in paediatric patients with systemic lupus erythematosus. (acronymfinder.com)
  • What are the uses and limitations of an antiphospholipid antibodies test for lupus? (webmd.com)
  • What is an antiphospholipid antibodies test for lupus? (webmd.com)
  • An antiphospholipid antibodies test can help confirm a diagnosis of lupus. (webmd.com)
  • What is an antinuclear antibody test for lupus? (webmd.com)
  • Intended for the in vitro quantitative measurement of antibodies directed to β2-Glycoprotein I in human serum and plasma to aid in the diagnosis of antiphospholipid syndrome (APS) and to evaluate the thrombotic risk in patients with systemic lupus erythematosus (SLE). (fishersci.com)
  • Lupus anticoagulants are antibodies against substances in the lining of cells. (umm.edu)
  • Antiphospholipid syndrome (APS) was suspected due to the prolonged APTT at both 0 and 2 h following incubation with normal serum and the positive antiphospholipid antibodies results (lupus anticoagulant 2. (thefreedictionary.com)
  • Moreover, their cumulative organ involvements and existence of cumulative antiphospholipid antibodies (anticardiolipin immunoglobulins M and G, lupus anticoagulant) and antiphospholipid syndrome (according to 2006 Sapporo criteria) were recorded. (thefreedictionary.com)
  • Neurocognitive dysfunction in systemic lupus erythematosus: association with antiphospholipid antibodies , disease activity and chronic damage. (thefreedictionary.com)
  • About 1 out of 3 people with lupus produce an antibody that attacks certain blood-clotting factors, which can cause the blood to clot easily. (uwhealth.org)
  • 1 The syndrome is associated with the presence of anticardiolipin antibodies or lupus anticoagulant, or both. (cmaj.ca)
  • Laboratory confirmation of the presence of antiphospholipid Ab (lupus anticoagulant or anticardiolipin Ab). (oncologynurseadvisor.com)
  • Positive anticardiolipin antibodies, lupus anticoagulant, and anti-B2 glycoprotein-I, as well as deranged coagulation profile and PTT mixing studies aided in the diagnosis of catastrophic antiphospholipid antibody syndrome. (biomedsearch.com)
  • This again, is a relatively old slide, demonstrating in a patient population with lupus and primary antiphospholipid antibody syndrome alone, the risk to pregnancy of having the antibody going from no antibody present (under 16 IgG antiphospholipid antibody units) to high titer on the first blood test drawn during the index pregnancy. (hss.edu)
  • Several antiphospholipid antibodies have been identified, the lupus anticoagulant being the most recognized. (jaoa.org)
  • However, over 25 years ago, a doctor thought I might have lupus, but did not tell me about the antibodies. (steadyhealth.com)
  • Antiphospholipid syndrome (APS), or Hughes syndrome, is an acquired autoimmune thrombophilia characterised by venous or arterial thrombosis and/or recurrent miscarriages due to the presence of autoantibodies to phospholipid-binding plasma proteins, such as the lupus anticoagulant, anticardiolipin antibody (aCL), and the anti-beta-2-glycoprotein antibody (aβ2GPI). (elsevier.es)
  • If the number of publications that use the keywords lupus anticoagulant, anticardiolipin antibodies, antiphospholipid antibodies, and antiphospholipid syndrome represents a measure of scientific interest, it is evident that an exponential increase in publications on these subjects began between 1984 and 1988 (see Figure 1). (the-rheumatologist.org)
  • A Medline search using the following keywords: lupus anticoagulant (LA), anticardiolipin (aCL), antiphospholipid (APL), and antiphospholipid syndrome (APS) was performed. (the-rheumatologist.org)
  • The risk of recurrent fetal loss is significantly higher in pregnant women with APL antibodies or lupus anticoagulant (LA) (1, 2, 3, 4). (who.int)
  • preeclampsia or eclampsia) with antibodies to phospholipids Evidence suggests, that anti- 2GPI antibodies activate (aPLs) and more specifically, anticardiolipin antibodies (aCL) endothelial cells by inducing intracellular adhesion molecule-1 or lupus anticoagulant (LA) (1). (scribd.com)
  • Most participants met Sapporo criteria for definite antiphospholipid syndrome, defined as persistent antiphospholipid antibodies (medium to high anticardiolipin antibody titres and /or lupus anticoagulant in tests repeated at least six weeks apart). (york.ac.uk)
  • Antiphospholipid syndrome (APS) is a disorder of blood coagulation related to the presence of autoantibodies called lupus anticoagulant and anticardiolipin. (healthtap.com)
  • When testing for Antiphospolipid Antibody Syndrome, does taking baby aspirin affect the Lupus Anticoagulant (PTT-LA, dRVVT) test results? (healthtap.com)
  • MADRID - The risks of specific manifestations of antiphospholipid syndrome and systemic lupus erythematosus are linked to the types and levels of antiphospholipid antibodies, according to study findings presented at the European Congress of Rheumatology. (mdedge.com)
  • Spanish researchers found that the number of antiphospholipid (aPL) antibodies present was important for the development of antiphospholipid syndrome (APS) and that lupus anticoagulant (LA) was the major aPL antibody linked to systemic lupus erythematosus (SLE)-related organ involvement. (mdedge.com)
  • Regarding systemic lupus erythematosus, the number of positive antibodies is directly associated with neurological and ophthalmological manifestations, and inversely associated with cutaneous manifestations. (mdedge.com)
  • We performed this observational study to investigate the relationship between maternal autoantibodies and antiphospholipid antibody syndrome (APS) in maternal lupus patients and neurocognitive development among their offspring. (umich.edu)
  • Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombotic manifestations and/or pregnancy-related complications in patients with persistently high antiphospholipid antibodies (aPL), the most common being represented by anticardiolipin antibodies (aCL), anti-beta 2 glycoprotein-I (aβ2GPI), and lupus anticoagulant (LAC). (haematologica.org)
  • The most frequently detectable aPL are anticardiolipin antibodies (aCL), antiβ2-glycoprotein I antibodies (anti-β2-GPI), and lupus anticoagulant (LAC). (haematologica.org)
  • 3 This definition was derived from clinical observation of recurrent miscarriages, central nervous system disease, and recurrent venous thromboembolism (VTE) in patients with systemic lupus erythematosus (SLE) and serum positivity for anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). (haematologica.org)
  • Antiphospholipid syndrome may affect the incidence and pathogenesis of cerebrovascular diseases in patients with systemic lupus erythematosus. (ajnr.org)
  • We compared the spectrum of MR findings in patients with systemic lupus erythematosus with and without antiphospholipid syndrome. (ajnr.org)
  • Recurrent stroke and multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. (pubmedcentralcanada.ca)
  • Lockshin MD, Druzin ML, Goei S, Qamar T, Magid MS, Jovanovic L, Ferenc M. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. (pubmedcentralcanada.ca)
  • Harris EN, Gharavi AE, Asherson RA, Boey ML, Hughes GR. Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. (pubmedcentralcanada.ca)
  • These tests check your blood for any of the three APS antibodies: anticardiolipin, beta-2 glycoprotein I (β2GPI), and lupus anticoagulant. (hoacny.com)
  • It may seem odd that one of the APS antibodies is called lupus anticoagulant. (hoacny.com)
  • Vascular disease is common in systemic lupus erythematosus (SLE) and patients with antiphospholipid antibodies (aPL) are at high risk to develop arterial and venous thrombosis. (diva-portal.org)
  • HLA-DRB1*13 was associated with AVE. All measured specificities of aPL-cardiolipin IgG and IgM, β 2 -glycoprotein-1 IgG, prothrombin (PT) IgG and a positive lupus anticoagulant test were associated with HLA-DRB1*04-while HLA-DRB1*13 was associated with IgG antibodies (β 2 -glycoprotein-1, cardiolipin and PT). (diva-portal.org)
  • Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus: evaluation of two diagnostic assays. (lu.se)
  • Antiphospholipid antibodies include anticardiolipin antibodies, the lupus anticoagulant, and antibeta-2 glycoprotein 1 antibodies. (endocrinologyadvisor.com)
  • The laboratory criteria are the presence of an elevated concentration of antiphospholipid antibodies, which includes a positive test for the lupus anticoagulant, present on 2 or more occasions at least 12 weeks apart. (endocrinologyadvisor.com)
  • The antiphospholipid antibody tests considered in this analysis are lupus anticoagulant, the anticardiolipin antibody, and the antibeta-2 glycoprotein 1 antibody. (endocrinologyadvisor.com)
  • In patients with systemic lupus, the presence of an antiphospholipid antibody increases the incidence of thromboembolic events 2- to 3-fold. (endocrinologyadvisor.com)
  • Prolongation of the PT can occur if the patient is also deficient in prothrombin (factor II) as a result of neutralizing antiprothrombin antibodies uncommonly present along with the lupus anticoagulant. (endocrinologyadvisor.com)
  • Lupus Anticoagulant & β2 GPI antibody were negative. (biomedcentral.com)
  • En s k rastlanan antikor IgG anti-β2 GPI idi (%37,5), bunu s ras yla antikardiyolipinler (%17,5) ve lupus antikoag lan (%5) izlemekteydi. (tjh.com.tr)
  • Its diagnosis is contingent upon the identification of antiphospholipid antibodies (aPL) by anticardiolipin (aCL), anti-β2-glycoprotein I (anti-β2GPI) and/or lupus anticoagulant (LA) tests. (springer.com)
  • The aPL antibodies are directed against phospholipids and their binding proteins and are frequently found in association with different connective tissue disorders (CTDs), such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), mixed connective tissue disease (MCTD) or SSc. (termedia.pl)
  • Antiphospholipid antibodies (aPL) have been associated with recurrent thrombosis (arterial and/or venous) and recurrent pregnancy losses in patients with systemic lupus erythematosus and in those with the antiphospholipid syndrome (APS) (1). (docme.ru)
  • The patient's lupus anticoagulant is positive, and we are now operating on the assumption that she has renal failure based on antiphospholipid antibody syndrome-induced TMA. (blogspot.com)
  • Antiphospholipid antibodies are a wide and heterogeneous group of immunoglobulins that include, among others, lupus anticoagulants and anticardiolipin antibodies. (thefreedictionary.com)
  • Livedo racemosa is a typical sign of Sneddon's syndrome and can be seen in up to 70% of patients with antiphospholipid-antibody syndrome and systemic lupus erythematosus. (thefreedictionary.com)
  • Among these group of antibodies, lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) prolong phospholipid-dependent coagulation assays. (statpearls.com)
  • Antiphospholipid syndrome can be primary when there is no evidence of autoimmune disease, or secondary to autoimmune processes like Systemic lupus erythematosus (SLE) in 40% of the cases. (statpearls.com)
  • One to five percent of the healthy young patients has anticardiolipin antibodies and lupus anticoagulant antibodies. (statpearls.com)
  • Forty percent of patients with Antiphospholipid syndrome have Systemic lupus erythematosus (SLE). (statpearls.com)
  • HI I am on this forum as I have Lupus, but I am also one of the Administrators from another forum on here which is for Sticky Blood-Hughes Syndrome, this is a forum for the Disease which is called Hughes Syndrome or APS, Antiphospholipid Syndrome, which is a sort of cousin of Lupus. (healthunlocked.com)
  • Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome, idiopathic spontaneous abortion, and systemic lupus erythematosus (SLE). (wikipedia.org)
  • Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortion. (wikipedia.org)
  • Systemic lupus erythematosus Periarteritis nodosa Eosinophilic vasculitis Hyperviscosity syndrome Polycythemia Hypercoagulability Protein C deficiency Antiphospholipid antibodies Anticardiolipin antibodies Lupus anticoagulant Thrombocytosis Subclavian steal syndrome Malignant hypertension can cause ischemia of the optic nerve head leading to transient monocular visual loss. (wikipedia.org)
  • In rheumatology, what we know is that IgG antibodies, as compared to IgM and IgA, are more strongly associated with the events included in the definition of APS, that is venous, small vessel, and arterial thrombosis and pregnancy morbidities. (medscape.com)
  • In one case, the fetus spontaneously aborted 5 days after the procedure secondary to antiphospholipid antibody syndrome, which had also triggered the thrombosis. (thefreedictionary.com)
  • The management of thrombosis in the antiphospholipid-antibody syndrome. (nih.gov)
  • The antiphospholipid-antibody syndrome is a thrombophilic disorder in which venous or arterial thrombosis, or both, may occur in patients with antiphospholipid antibodies. (nih.gov)
  • One hundred forty-seven patients (124 [84 percent] of whom were female) with the antiphospholipid-antibody syndrome and a history of thrombosis were studied retrospectively. (nih.gov)
  • The risk of recurrent thrombosis in patients with the antiphospholipid-antibody syndrome is high. (nih.gov)
  • Antiphospholipid antibody syndrome manifesting as a deep venous thrombosis and pulmonary embolism in a patient with HIV. (acronymfinder.com)
  • The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and obstetric complications (miscarriages, stillbirths). (clinicaltrials.gov)
  • Antiphospholipid antibody syndrome (APS) is a multisystem disorder characterized by vascular thrombosis and presence of circulating autoantibodies. (unboundmedicine.com)
  • Antiphospholipid syndrome, Hughes syndrome, or antiphospholipid antibody syndrome is a disorder that causes blood clots (thrombosis) to form in the arteries, veins, and vital organs. (patientslikeme.com)
  • The antiphospholipid syndrome (APS) is characterised by the presence of antiphospholipid antibodies (aPA) associated with thrombosis (arterial and venous) and pregnancy morbidity. (bl.uk)
  • Antiphospholipid antibody syndrome (APS), also known as Hughes syndrome, is an acquired autoimmune thrombotic disorder characterized by venous and/or arterial thrombosis or obstetrical complications. (oncologynurseadvisor.com)
  • Although the exact pathophysiology is not known, the antiphospholipid antibodies are thought to activate endothelial cells, monocytes and platelets resulting in increased synthesis of tissue factor and thromboxane A2 causing thrombosis in the vascular bed. (oncologynurseadvisor.com)
  • Activation of the complement cascade is an important mechanism for antiphospholipid antibody-mediated thrombosis. (sigmaaldrich.com)
  • We examined the effects of rEV576 (coversin), a recombinant protein inhibitor of complement factor 5 activation, on antiphospholipid antibody-mediated tissue factor up-regulation and thrombosis. (sigmaaldrich.com)
  • Beginning in the early 1990s, the development of in vivo mouse models, supported by in vitro studies, provided compelling evidence for a role of these antibodies in thrombosis, pregnancy loss, and thrombocytopenia. (the-rheumatologist.org)
  • The optimal management of aPL antibody-related clinical manifestations, in particular, thrombosis and recurrent pregnancy loss, remains controversial. (the-rheumatologist.org)
  • The confirmation of diagnosis of the APS relies on laboratory tests because clinical manifestations such as thrombosis and pregnancy losses may occur for many reasons not related to the presence of aPL antibodies. (the-rheumatologist.org)
  • APL antibodies facilitate arterial and venous thrombosis. (who.int)
  • 2GPI antibodies induce the precoagulant activity of the endo- tide were associated with arterial thrombosis and/or brain thelium by cross-linking the 2 glycoprotein I ( 2GPI) on the microinfarcts. (scribd.com)
  • Antiphospholipid syndrome (APS) is an acquired, immune- is the main target of aPL/anti- 2GPI antibodies on the cell sur- mediated thrombophilia, defined as a combination of thrombo- face, and that antibodies recognizing 2GPI are considered sis or pregnancy morbidity (recurrent abortions, fetal deaths, rather powerful predictive factors for thrombosis (6). (scribd.com)
  • 3.0 for arterial and/or recurrent events, in patients with thrombosis and definite antiphospholipid antibodies. (york.ac.uk)
  • To assess the efficacy and safety of therapies for patients with antiphospholipid antibodies and thrombosis. (york.ac.uk)
  • aPL [antibodies] has been extensively associated with an increased risk of thrombosis and poor pregnancy outcomes, mainly in patients with primary APS," study investigator Leyre Riancho-Zarrabeitia, MD, PhD, explained in an interview ahead of the congress. (mdedge.com)
  • aCL antibodies conferred the highest risk for arterial thrombosis, she noted (odds ratio, 5.7), whereas LA conferred the highest risk for venous thrombosis (OR, 4.7). (mdedge.com)
  • For example, when one antibody was present the OR for arterial thrombosis was 4.45, but when two or more aPL were detected, the ORs rose to 9.23 and 15.6, respectively. (mdedge.com)
  • Nevertheless, the negativity to classic aPL criteria does not imply that other antibodies may be present or involved in the onset of thrombosis. (haematologica.org)
  • For patients manifesting antiphospholipid syndrome as thrombosis, venous thrombosis is more common than arterial. (endocrinologyadvisor.com)
  • In general, the more antiphospholipid antibody tests that are positive and the greater the positivity of the test, the greater the risk is for thrombosis and for pregnancy complications. (endocrinologyadvisor.com)
  • Antiphospholipid antibodies (APLA) are a group of autoantibodies, which have been reported in Antiphospholipid syndrome (APS), which is characterized by raised levels of ACLA, thrombosis, recurrent fetal loss & thrombocytopenia. (biomedcentral.com)
  • Antiphospholipid antibodies and intracardiac thrombosis. (minervamedica.it)
  • Thrombosis and thrombocytopenia are features of the antiphospholipid syndrome (APS), suggesting that antiphospholipid antibodies (aPL) may bind platelets, causing activation and aggregation of platelets and thrombosis. (docme.ru)
  • a disorder characterized by the presence of antiphospholipid antibodies in patients with arterial and venous thrombosis, and/or obstetric complications. (thefreedictionary.com)
  • Genetic risk factors heighten the risk of antiphospholipid antibody associated thrombosis, such as coagulation factor mutations. (statpearls.com)
  • A "two-hit" thrombosis model is proposed to explain thrombus formation in patients with antiphospholipid syndrome. (statpearls.com)
  • Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis. (wikipedia.org)
  • One 5ml non-anticoagulated serum sample for Anticardiolipin antibody testing. (guysandstthomas.nhs.uk)
  • We evaluated inter-assay variation in anticardiolipin antibody status, comparing three centres, and using different assays among 36 women with recurrent miscarriage and 26 controls. (ingentaconnect.com)
  • anticardiolipin antibody (aCL) by enzyme-linked immunosorbent assay (ELISA) and anti-B2 glyoprotenin 1 antibody (aB2GP1) by ELISA. (oncologynurseadvisor.com)
  • Anticardiolipin antibody (immunoglobulin G (IgG) and/or immunoglobulin M (IgM) isotype) in serum or plasma, present in medium or high titers (greater than 40 IgG or IgM phospholipid units, or 99th centile) on two or more occasions at least 12 weeks apart, measured by a standardized enzyme-linked immunosorbent assay (ELISA). (oncologynurseadvisor.com)
  • Immunoglobulin G anticardiolipin antibody was the only single test of aPL significantly associated with fetal loss. (annals.org)
  • Antiphospholipid syndrome (APS) , also called Hughes syndrome, is a recognized group of signs and symptoms that includes the formation of blood clots, miscarriages, platelet deficiency (thrombocytopenia), and the presence of one or more antiphospholipid antibodies. (labtestsonline.org)
  • A person who has these antibodies and has had blood clots is said to have antiphospholipid antibody syndrome. (rexhealth.com)
  • Antiphospholipid syndrome (APS) , also called Hughes syndrome, is a recognised group of signs and symptoms that includes the formation of thrombi (blood clots), recurrent miscarriages, thrombocytopenia, and the presence of one or more antiphospholipid antibodies. (labtestsonline.org.uk)
  • People with antibodies to phospholipids (aPL) may have a very high risk of forming blood clots. (umm.edu)
  • Antiphospholipid Antibody Syndrome (APL) is an autoimmune disease that increases ones risk for blood clots. (clinicaltrials.gov)
  • Clinical problems associated with antiphospholipid antibodies include an increased risk for the formation of blood clots in the lungs or deep veins of the legs, stroke, heart attack, and recurrent miscarriages. (centerwatch.com)
  • The presence of these antibodies and associated complications (e.g. blood clots) are known to change over time. (clinicaltrials.gov)
  • Antiphospholipid syndrome can cause blood clots to form within your arteries or veins as well as pregnancy complications , such as miscarriages and stillbirths. (healthtap.com)
  • Pregnant women who need LMWH for either current or prior blood clots, recurrent miscarriage, or antiphospholipid-antibody syndrome have few alternatives for treatment. (thefreedictionary.com)
  • Antiphospholipid antibodies are a group of immune proteins ( antibodies ) that the body mistakenly produces against itself in an autoimmune response to phospholipids. (labtestsonline.org)
  • Antiphospholipid (APL) antibodies are group of antibodies directed against epitopes on plasma proteins that are uncovered by binding of these proteins to anionic phospholipids on plasma membranes. (medscape.com)
  • Antiphospholipid antibody tests are immune proteins ( antibodies ) directed against phospholipids. (labtestsonline.org.uk)
  • Antiphospholipid Antibodies (APLA) are a group of autoantibodies, all recognising various combinations of phospholipids. (thefreedictionary.com)
  • Antiphospholipid antibodies form against a group of fatty molecules located in the outer membrane of the cell known as phospholipids. (repro-med.net)
  • Under certain abnormal conditions, unusually high quantities of antibodies can form directed against the phospholipids or related proteins. (repro-med.net)
  • There are numerous potential phospholipids and proteins that antibodies can form against. (repro-med.net)
  • All had livedo reticularis, severe migraines, and also demonstrated antibodies to phospholipids. (pubmedcentralcanada.ca)
  • Antiphospholipid syndrome is an autoimmune disease with antibodies against membrane phospholipids with mainly thrombotic and/or obstetric manifestations. (elsevier.es)
  • Triple antibody positivity is considered the most noteworthy risk factor. (unboundmedicine.com)
  • Moreover, aPL [antibody] positivity in SLE has been proposed to be associated with higher damage accrual and with certain manifestations such as valvular heart disease, pulmonary hypertension, and neuropsychiatric manifestations," she added. (mdedge.com)
  • aPL [antibody] positivity in SLE patients influenced the risk for thrombotic and obstetric manifestations," Dr. Riancho-Zarrabeitia said. (mdedge.com)
  • Positivity was found for anti-SSA (60 kDa) and for antibodies routinely tested for Antiphospholipid Antibody Syndrome (APS), i.e. (omicsonline.org)
  • Patients with primary antiphospholipid syndrome, especially those with obstetric antiphospholipid syndrome and triple antibody positivity, are at higher risk for adverse pregnancy outcomes. (sclero.org)
  • The antiphospholipid antibody syndrome (APLS) is the most important treatable cause for recurrent miscarriage. (thefreedictionary.com)
  • The anti-phospholid antibody screen is a popular test, especially among women who have experienced recurrent miscarriage and continued implantation failure. (sharedjourney.com)
  • Some women, however, produce APA blood-clotting antibodies which attack cells that build the placenta and increase the risk of miscarriage. (marilynglenville.com)
  • Women with antiphospholipid antibodies (aPL) are at risk for recurrent miscarriage, pre-eclampsia, and pre-term labor. (nih.gov)
  • Repeated miscarriage and implantation failure may be caused in part by antiphospholipid antibodies. (repro-med.net)
  • Testing for antiphospholipid antibodies is important in patients who suffer recurrent miscarriage and unexplained infertility. (repro-med.net)
  • On the other hand, trials of women with antiphospholipid antibody syndrome have shown that pregnancy outcomes are improved with the use of aspirin plus heparin. (acronymfinder.com)
  • Whether a woman with antiphospholipid antibodies meets diagnostic criteria for antiphospholipid syndrome makes a huge difference in her risk of pregnancy failure. (thefreedictionary.com)
  • Antiphospholipid antibody syndrome is defined by the presence of thromboembolic complications and/or pregnancy morbidity in the presence of persistently increased titers of antiphospholipid antibodies. (dovepress.com)
  • Thus, the TLR-4/MyD88 pathway may provide a new therapeutic target to improve pregnancy outcome in antiphospholipid syndrome patients. (nih.gov)
  • The yellow bars are women who have had prior losses, and you can see that in this group of patients the history of a prior fetal loss and a high titer antibody gave an over 80% probability of losing the current pregnancy. (hss.edu)
  • Predicted losses in a woman who had never been pregnant but who had high titer antibody had about a 40% probability of losing that pregnancy. (hss.edu)
  • Moreover, since some form of therapy is initiated in most women with APL and pregnancy loss, it is nearly impossible to assess the effects of these antibodies on pregnancy outcome (if APL were left untreated). (who.int)
  • To determine if the presence of antiphospholipid antibody (aPL) in healthy pregnant women is associated with adverse pregnancy outcome, including 1) intrauterine fetal loss, 2) maternal pregnancy complications, 3) low birth weight, and 4) low 5-minute Apgar scores. (annals.org)
  • Antiphospholipid syndrome is a systemic autoimmune disorder characterized by arterial and venous thrombotic manifestations and/or pregnancy morbidity in patients with persistently high levels of aPL. (haematologica.org)
  • To determine the frequency of preterm deliveries and postpartum thrombotic events (TE) in pregnancies resulting in live birth in women with antiphospholipid antibodies (aPL) and a history of recurrent pregnancy loss (RPL) but without prior TE.Methods. (eurekamag.com)
  • It is well known that treatment with aspirin plus heparin is effective for patients with antiphospholipid syndrome (APS) to prevent pregnancy loss. (babymed.com)
  • Antiphospholipid syndrome (APLS) comprises the identification of antiphospholipid antibodies in the setting of arterial and venous thrombus and/or pregnancy loss. (statpearls.com)
  • Antiphospholipid Antibody Syndrome is a topic covered in the 5-Minute Clinical Consult . (unboundmedicine.com)
  • Fifty-seven patients (47 females, 10 males) with APS were studied for clinical manifestations and serological markers of the disease, as well as the presence of anti-endomysial antibodies using an ELISA assay (EMA-ELISA). (nih.gov)
  • Patients with antiphospholipid antibody syndrome may display a constellation of clinical features ( Box 2 ). (cmaj.ca)
  • This thesis has aimed to investigate the frequency of protein C pathway defects in patients with aPA and to study clinical correlates examine the mechanisms of antiphospholipid interference in the protein C pathway and to assess activated protein C (APC) resistance in patients with aPA in terms of thrombin generation. (bl.uk)
  • Disease activity tends to correlate with antibody titer and IgG isotype is generally more commonly associated with clinical events than IgM. (oncologynurseadvisor.com)
  • A comparison of the haematological and clinical features of patients with positive and negative antiphospholipid sickle cell disease did not highlight any differences between the groups. (bmj.com)
  • Treatment strategies for the clinical manifestations of the antiphospholipid antibody syndrome are being developed. (jaoa.org)
  • Since the mid-1980s, antiphospholipid (aPL) antibodies and their associated clinical manifestations have attracted great interest among clinicians and investigators. (the-rheumatologist.org)
  • 1-3 A dramatic boost in clinical interest came with the introduction of the anticardiolipin (aCL) test and subsequent efforts to link this test, as well as the LAC test, to a "new" condition, namely, antiphospholipid syndrome (APS). (the-rheumatologist.org)
  • In this retrospective study, we evaluated the clinical relevance of antibodies to phosphatidylserine/prothrombin (aPS/PT) in Chinese patients with APS. (degruyter.com)
  • This research is in continuous development as the clinical relevance of these antibodies is far from being completely clarified. (haematologica.org)
  • In this review, we will discuss criteria for defining the SN-APS, the new potential non-criteria antibodies implied in SN-APS and its clinical management. (haematologica.org)
  • OBJECTIVE: We carried out a prospective analysis of clinical and analytical findings in individuals with antiphospholipid antibodies (aPL). (jrheum.org)
  • The current classification criteria for antiphospholipid syndrome include both laboratory criteria and clinical criteria. (endocrinologyadvisor.com)
  • The diagnosis of antiphospholipid syndrome (APLS) includes clinical and laboratory criteria. (statpearls.com)
  • Patients diagnosed with antiphospholipid syndrome (APS) are also at risk of valvular abnormalities. (medscape.com)
  • Dissolution of intracardiac mass lesions in the primary antiphospholipid antibody syndrome. (thefreedictionary.com)
  • Mesenteric and portal venous obstruction associated with primary antiphospholipid antibody syndrome. (acronymfinder.com)
  • We describe a woman with thrombocytopenia associated with primary antiphospholipid syndrome who responded to dapsone therapy. (annals.org)
  • No underlying systemic disease could be diagnosed after extensive investigations, leading to the diagnosis of primary antiphospholipid antibody (aPLAb) syndrome (APS). (haematologica.org)
  • There are a number of complications associated with high levels of antiphospholipid antibody. (sharedjourney.com)
  • Platelet activation by anti- 2GPI antibodies may according to American College of Rheumatology Criteria (22), also contribute to thrombotic complications in patients with were tested. (scribd.com)
  • While increased antibody numbers generally led to a higher risk of complications, the risk for cutaneous manifestations decreased. (mdedge.com)
  • No statistically significant association of positive antiphospholipid-related tests to any of the scleroderma complications could be demonstrated. (tjh.com.tr)
  • It would be useful to follow a cohort of patients affected by systemic scleroderma in order to monitor vascular complications following confirmation of the presence of antiphospholipid syndrome. (tjh.com.tr)
  • Because antiphospholipid antibodies (aPLs) can come and go or increase and decrease, "it could be that the antibodies are a reaction to the tissue damage of the MI since the blood samples were taken 6 to 10 weeks after the infarction," she said. (medscape.com)
  • Increasing evidence has highlighted the role of non-criteria antiphospholipid antibodies (aPLs) as important supplements to the current criteria aPLs for the diagnosis of antiphospholipid syndrome (APS). (degruyter.com)
  • Objective: Antiphospholipid antibodies (APLs) could be associated with an increased risk of vascular pathologies in systemic scleroderma. (tjh.com.tr)
  • Recent studies showed that total antioxidant status in the plasma was decreased (8, 9), serum antiphospholipid antibody levels were elevated, which is a risk factor for cardiovascular and cerebrovascular diseases (10), connective tissue growth factor was increased (11) in patients with PEX. (thefreedictionary.com)
  • Patient was further investigated for all possible causes of peripheral gangrene which included antiphospholipid antibody testing (ACL Ig G and Ig M and LAC which all were negative), lipid profile (Serum chol sterol 140 mgs/dl, Serum TG 110 mg/dl, HDL-chol 40 mg/dl), antinuclear antibody and rheumatoid factors were negative too. (thefreedictionary.com)
  • Anti-β 2 glycoprotein I antibody (IgG and/or IgM isotype) present in medium or high titer (greater than 40 IgG or IgM phospholipid units, or greater than 99th centile) in serum or plasma, present on two or more occasions at least 12 weeks apart, measured by a standardized ELISA. (oncologynurseadvisor.com)
  • Groups of C57BL/6J mice (n=5) received either IgG from a patient with antiphospholipid syndrome (APS) or control IgG from normal human serum (NHS). (sigmaaldrich.com)
  • Serum samples from 108 unselected Jamaican patients with homozygous sickle cell disease and 116 control subjects with normal haemoglobin were screened for the presence of antiphospholipid antibodies. (bmj.com)
  • My serum test is negative for endomysial antibody iga, ttg tissue transglutasminase iga, gliadin antibody igg. (healthtap.com)
  • Several assays have been designed for the detection of antiphospholipid antibodies. (jaoa.org)
  • Moreover, the assays to measure the levels of these antibodies have not yet been standardized. (haematologica.org)
  • Beta-2 glycoprotein 1 testing may be ordered along with the other antiphospholipid antibodies to detect their presence and to provide the healthcare practitioner with additional information. (labcorp.com)
  • Per antiphospholipid syndrome diagnostic criteria, these anti-β 2 -glycoprotein I antibodies of IgG and/or IgM isotype should be present in the in plasma, in a titer greater than the 99th percentile to be considered a positive test result. (medscape.com)
  • We found that levels of anti-cardiolipin, β 2-glycoprotein 1, and anti-phosphoserine antibodies were elevated in children with ASD compared with age-matched TD and DD controls. (hindawi.com)
  • The first is the test for cardiolipin or beta2 glycoprotein I antibodies. (labtestsonline.org.uk)
  • If present in the patient's specimen, antibodies to β2-Glycoprotein I bind to their specific antigen. (fishersci.com)
  • Antibodies against beta2-glycoprotein-I (beta2GPI) epitopes (GRTCPKPDDLP) were more prevalent in EMA-positive patients than in EMA-negative patients (P = 0.006). (nih.gov)
  • EMA-ELISA antibodies are common in APS, and their presence is associated with high prevalence of antibodies recognizing certain beta2-glycoprotein epitopes, and with cutaneous manifestations of APS. (nih.gov)
  • Anticardiolipin (aCL) and anti-β 2 -glycoprotein I (β 2 GPI) antibodies (IgG and IgM) were assessed after the end of patients' inclusion. (bmj.com)
  • A non-complement-fixing antibody to β2 glycoprotein I as a novel therapy for antiphospholipid syndrome. (trieste.it)
  • Cardiolipin and β(2) glycoprotein-I antibodies were measured with routine ELISA and a new automated method. (lu.se)
  • Anticardiolipin antibodies are actually antibodies that bind to a protein, called beta-2 glycoprotein 1. (endocrinologyadvisor.com)
  • These antibodies are identified by detecting their binding to beta-2 glycoprotein 1 in association with cardiolipin. (endocrinologyadvisor.com)
  • Antibeta-2 glycoprotein 1 antibodies are identified by their binding directly to the antibeta-2 glycoprotein 1 protein. (endocrinologyadvisor.com)
  • Patients with antiphospholipid syndrome have lower levels of the reduced, protective, and non-immunogenic beta-2 glycoprotein I. Annexin A2, an endothelial cell surface receptor, is up-regulated with oxidative stress. (statpearls.com)
  • Tissue factor expression is upregulated by antiphospholipid antibodies through some intracellular signaling pathways after binding the anti-beta 2 glycoprotein I autoantibodies to the monocytes' surface and endothelial cells' multiprotein complexes. (statpearls.com)
  • Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In autoimmune disease, ACA are beta-2 glycoprotein dependent In syphilis, ACA are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease. (wikipedia.org)
  • Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. (wikipedia.org)
  • Different antiphospholipid antibody (APA) profiles in patients with immune thrombocytopenia (ITP) may affect individual response to ITP-specific treatments, according to a study published in Hematology (2019;24[1]:134-138). (pdsa.org)
  • Antiphospholipid antibodies (APLA) have been shown to activate endothelial cells (EC) in vitro, as documented by an increased expression of tissue factor as well as leukocyte adhesion molecules such as intercellular adhesion molecule-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin. (ovid.com)
  • This was accompanied by a steep rise in D-dimer levels and positive antiphospholipid antibodies (APLA) on further testing. (cureus.com)
  • All three patients were positive for antiphospholipid antibody (APLA). (smj.org.sg)
  • Antiphospholipid antibodies are proteins that circulate around in the bloodstream. (sharedjourney.com)
  • Antiphospholipid antibody syndrome (APS) is characterized by the presence of antiphospholipid antibodies, which are proteins in the blood that interfere with the body's ability to perform normal blood clotting. (centerwatch.com)
  • This is a study about why some people have certain types of proteins in their blood, called anti-phospholipid antibodies. (clinicaltrials.gov)
  • Antiphospholipid syndrome is a disorder in which your immune system mistakenly produces antibodies against certain normal proteins in your blood. (healthtap.com)
  • Antiphospholipid antibodies are autoantibodies directed against phospholipid-binding proteins. (statpearls.com)
  • In light of this, further research is warranted into a highly promising alternative hypothesis: that in utero exposure to SLE-related autoantibodies, such as anti-DNA and antiphospholipid antibodies , may play a causative role, said Dr. (thefreedictionary.com)
  • High prevalence of coeliac disease (CD) has been reported in various autoimmune disorders, buthas not been studied in the antiphospholipid syndrome (APS). (nih.gov)
  • We aimed to establish the prevalence of CD antibodies in a cohort of APS patients, and to examine whether CD may be responsible for some of the manifestations of APS. (nih.gov)
  • The prevalence of antiphospholipid antibodies (aPL) in the general population is difficult to estimate due to the lack of population-based studies. (haematologica.org)
  • Although raised levels of these antibodies were first reported only in autoimmune diseases, their prevalence is now known to be more widespread. (biomedcentral.com)
  • The aim of this study was to examine the prevalence and functional effects of antibodies directed against Factor (F)Xa and other serine proteases (SP) in patients with antiphospholipid syndrome (APS). (springer.com)
  • The prevalence of aPL antibodies in SSc ranges from 13 to 50% but antiphospholipid syndrome (APS) occurs in less than 1 % of SSc patients [5-9]. (termedia.pl)
  • The prevalence of other antibodies increases with age and chronic diseases. (statpearls.com)
  • Intracellular events in platelet activation induced by antiphospholipid antibodies in the presence of low doses of thrombin. (docme.ru)
  • Antiphospholipid antibodies are also associated with low platelet counts ( thrombocytopenia ) and with the risk of recurrent miscarriages (especially in the second and third trimester), premature labor, and pre-eclampsia . (labtestsonline.org)
  • Antiphospholipid antibodies are also associated with thrombocytopenia (low platelets) and with the risk of recurrent miscarriages (especially in the 2nd and 3rd trimester), premature labour, and pre-eclampsia . (labtestsonline.org.uk)
  • Kavanaugh [1] recently reported the beneficial effect of danazol on thrombocytopenia in a patient with the antiphospholipid antibody syndrome. (annals.org)
  • Lesprit P, Godeau B, Wechsler B. Dapsone in Thrombocytopenia of the Antiphospholipid Antibody Syndrome. (annals.org)
  • Connective tissue disorders with aPL antibodies may cause a diagnostic dilemma as many manifestations, e.g. hemolytic anemia, thrombocytopenia, neurologic manifestations, leg ulcerations, serositis, proteinuria, deterioration of GFR, may occur in both, CTDs and diseases associated with the presence aPL antibodies [5]. (termedia.pl)
  • Antiphospholipid antibody syndromes are primarily manifested as unexplained thrombotic events. (jaoa.org)
  • Introduction: Circulating antiphospholipid antibodies (APL) induce vascular injury and endothelial dysfunction, which are associated with thrombotic events and/or fetal loss. (inserm.fr)
  • Researchers hope to develop treatments that target the aPL antibodies, so preventing them from causing thrombotic events. (healthguideinfo.com)
  • A case of tricuspid valve non-bacterial thrombotic endocarditis presenting as pulmonary embolism in a patient with antiphospholipid antibody syndrome -- Unnikrishnan et al. (bmj.com)
  • Anti-phospholipid antibodies are believed to occur from both genetic and environmental factors and have been linked to a number of neuropsychiatric symptoms such as cognitive impairments, anxiety, and repetitive behaviors. (hindawi.com)
  • In the current study, we investigated whether there were elevated levels of anti-phospholipid antibodies in a cross-sectional analysis of plasma of young children with ASD compared to age-matched typically developing (TD) controls and children with developmental delays (DD) other than ASD. (hindawi.com)
  • This study provides the first evidence for elevated production of anti-phospholipid antibodies in young children with ASD and provides a unique avenue for future research into determining possible pathogenic mechanisms that may underlie some cases of ASD. (hindawi.com)
  • Anti-phospholipid syndrome is a disorder of the immune system, where abnormal antibodies, called antiphospholipid antibodies (aPL) are produced. (thefreedictionary.com)
  • Shah S, Larson A, Datta Y. Calciphylaxis in catastrophic antiphospholipid antibody syndrome. (unboundmedicine.com)
  • Catastrophic antiphospholipid antibody syndrome in a young woman in the postpartum period. (biomedsearch.com)
  • Preliminary diagnostic criteria of catastrophic antiphospholipid syndrome. (elsevier.es)
  • Catastrophic antiphospholipid syndrome (CAPS) is a severe and rapidly progressive form that affects multiple organs simultaneously and causes multiple organ failure. (elsevier.es)
  • Patients who develop multiple thromboses over days, despite appropriate anticoagulation, and experience adrenal failure, myocardial infarction, stroke, or liver failure may be suffering from catastrophic antiphospholipid syndrome. (endocrinologyadvisor.com)
  • Catastrophic Antiphospholipid Syndrome (CAPS) describes a rare subset (about 1%) of patients with APLAS who develop significant end-organ damage as a result of widespread thrombotic occlusion. (blogspot.com)
  • Antiphospholipid antibody syndrome is a blood-clotting disorder that makes the blood clot too easily. (rexhealth.com)
  • The presence of antiphospholipid antibodies in your blood indicates a disorder of your immune system called antiphospholipid syndrome. (steadyhealth.com)
  • Antiphospholipid antibody syndrome, a blood-clotting disorder, is also associated with recurrent first-trimester miscarriages. (awomanshealth.com)
  • Some people have APS antibodies but no signs or symptoms of the disorder. (hoacny.com)
  • To be diagnosed with APS, you must have APS antibodies and a history of health problems related to the disorder. (hoacny.com)
  • There are 21 different types of antiphospholipid antibodies. (sharedjourney.com)
  • There are 23 types of antiphospholipid antibodies and some of them can, for example, make syphilis test falsely positive - that is VDRL/RPR type. (steadyhealth.com)
  • Serial control samples confirmed the increased levels of antiphospholipid antibodies. (bmj.com)
  • Furthermore, resources for the detection of antiphospholipid antibodies should be made readily available in resource-limited settings. (dovepress.com)
  • This is one of the first patients I ever saw here at this hospital, probably 20 years ago, before we had a diagnosis of the antiphospholipid syndrome. (hss.edu)
  • Cardiolipin antibodies (IgG, IgM, and sometimes IgA) are frequently ordered since they are the most common antiphospholipid antibodies. (labcorp.com)
  • There are two types of tests that are used to detect antiphospholipid antibodies. (labtestsonline.org.uk)
  • A blood test can detect antiphospholipid antibodies. (uwhealth.org)
  • 12] MPL units) but negative for IgG cardiolipin antibodies. (cmaj.ca)
  • This is in contrast to rheumatoid arthritis with systemic sclerosis (scleroderma) because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. (wikipedia.org)
  • The routine use of rituximab cannot be recommended as the single series published to date interestingly reported no reduction in antiphospholipid antibody titer and only improvement in some but not all non-criteria manifestations of APS. (thefreedictionary.com)
  • Importantly, testing for the various antibodies associated with APS has been the source of much controversy, particularly regarding the performance of different tests, measurement of antibody levels, and the extent of association of any serological finding with the various disease manifestations. (the-rheumatologist.org)
  • Anticardiolipin antibodies - notably IgG rather than IgM isotypes - also seemed to play an important role in APS and SLE manifestations, Dr. Riancho-Zarrabeitia, of Hospital Sierrallana, Instituto De Investigación Marqués De Valdecilla, and the University of Cantabria (Spain), noted during her oral presentation. (mdedge.com)
  • What these findings show, said Dr. Riancho-Zarrabeitia in the precongress interview, is that individuals who test positive for aPL antibodies need careful monitoring to prevent and treat severe manifestations. (mdedge.com)
  • Nonthrombotic manifestations of antiphospholipid syndrome include a host of cardiovascular diseases, neurologic disorders, hematologic disorders, renal dysfunction, and cutaneous changes. (endocrinologyadvisor.com)
  • Currently, treatment of patients with the antiphospholipid syndrome includes aspirin, particularly for women with recurrent fetal loss. (ovid.com)
  • Antiphospholipid antibodies (APAs) are the most common kind of abnormal immune system problem. (marilynglenville.com)
  • Women with ACL antibodies have 3-9 times greater risk of fetal loss (2, 3, 6). (who.int)
  • Heparin or aspirin or both in the treatment of recurrent abortions in women with antiphospholipid antibody (syndrome). (thefreedictionary.com)
  • Pregnant women with antiphospholipid antibody syndrome need to be closely monitored. (uwhealth.org)
  • The purpose of this study is to determine the effects of a medication, hydroxychloroquine (HCQ), on a blood test called the annexin A5 (AnxA5) resistance assay in people with antiphospholipid antibodies (aPL). (hss.edu)
  • Since 1999 the Sapporo Criteria for Antiphospholipid Syndrome diagnosis includes the development of fetal growth restriction (diagnosed postpartum), but this was done without solid evidence of a relation between the two or using the most common form of fetal growth restriction diagnosis (ultrasound). (clinicaltrials.gov)
  • Since 1999 the Sapporo Criteria for Antiphospholipid Syndrome diagnosis includes the development of severe preeclampsia before 34 weeks of gestation , but this was done without solid evidence of a relation between the two. (clinicaltrials.gov)
  • We present the case of a patient who presented with skin necrosis secondary to antiphospholipid antibody syndrome despite being on therapeutic anticoagulation and then developed dystrophic calcification secondary to her renal insufficiency. (unboundmedicine.com)
  • The differential diagnosis of calciphylaxis includes antiphospholipid-antibody syndrome , warfarin-induced skin necrosis, purpura fulminans, microembolization, pyoderma gangrenosum, and necrotizing fasciitis. (thefreedictionary.com)
  • A 48-year-old woman with antiphospholipid syndrome (APS) had multiple skin necrosis caused by massive bleeding and hematoma collection at the right lower leg, left thigh, and abdomen. (ipodiatry.org)
  • The presence of phospholipid antibodies in some instances may be temporary and they have been identified in some individuals who have no detectable illnesses. (labtestsonline.org)
  • ELISA is the test used to detect these antibodies, IgM and IgG isotypes. (medscape.com)
  • Eight patients with APS (14%, six females) were found to have EMA-ELISA antibodies, compared with 2/141 (1.1%) of controls (P = 0.0003). (nih.gov)
  • Diagnostic Confirmation: Are you sure your patient has antiphospholipid antibody syndrome? (oncologynurseadvisor.com)
  • However the generally accepted diagnostic criteria is persistently raised antiphospholipid antibodies in the blood. (healthguideinfo.com)
  • patient/control ratio: 1.85) was evidenced, but no further specific investigations were performed associated with positive antinuclear antibodies. (haematologica.org)
  • A valine 247/leucine polymorphism in β 2 -GP1 could be a genetic risk for the presence of anti- β 2 -GP1 antibodies and APS. (unboundmedicine.com)
  • The other independent predictors of a first cardiovascular event were the presence of any positive antiphospholipid antibody test, which conferred a 4. (acronymfinder.com)
  • Patients with hyperthyroidism have increased risk for developing thromboembolic accidents, which are favoured by a simultaneous presence of antiphospholipid antibodies syndrome. (hindawi.com)
  • Known presence of antiphospholipid antibodies. (clinicaltrials.gov)
  • The authors conclude that clinicians need to have a high index of suspicion of APS in patients who present with a thrombotic episode - clinicians should investigate for the presence of antiphospholipid antibodies, as early diagnosis may influence the course of the disease. (dovepress.com)
  • Proposed mechanisms explaining the degree of retina ischemia as it relates to the presence of antiphospholipid antibodies will be discussed. (arvojournals.org)
  • Both address presence of antibody to the rhyroglobulin molecule made by thyroid gland. (healthtap.com)
  • We conclude that increased TAFI antigen levels and impaired fibrinolysis are pathogenetic factors in preeclampsia, regardless of whether or not preeclampsia is associated with the presence of antiphospholipid antibodies. (biomedsearch.com)
  • The presence of LA, but not other antiphospholipid antibodies, was also associated with increased SE services usage. (umich.edu)
  • In the literature available, there are some data about the influence of aPL presence on GFR but no information about long - term influence of aPL antibodies on GFR in patients with SSc [5, 6, 8]. (termedia.pl)
  • That's the major question and, if so, then if every 10th person with a myocardial infarction in the general population has these antibodies, maybe we can help with anticoagulation. (medscape.com)
  • Endothelial cells were incubated with the purified anti-β2glycoprotein I antibodies of patients with antiphospholipid syndrome (APS). (inserm.fr)
  • Mice treated with IgG-APS had significantly higher titers of anticardiolipin antibodies and anti-β2GPI at thrombus induction compared with those treated with IgG-NHS. (sigmaaldrich.com)
  • There was stepwise increment from negative titers but it was also true that the history of a prior loss even in women who had negative antibody titers also predicted loss at about a 2:1 ratio, that is, a prior loss plus the high titer antibody. (hss.edu)
  • We present a case with Leprosy & gangrene with positive anti phopholipid antibody titers. (biomedcentral.com)