Antibodies antineutrophil cytoplasmic. Medical search

Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.

Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.

A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).

Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.

A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.

Immunoglobulins produced in response to VIRAL ANTIGENS.

Antibodies produced by a single clone of cells.

Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.

A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)

A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.

Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.

Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.

Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.

Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.

Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.

Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.

A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.

Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.

Immunoglobulins produced in a response to FUNGAL ANTIGENS.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.

Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.

Antibodies reactive with HIV ANTIGENS.

ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

Sites on an antigen that interact with specific antibodies.

Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.

Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.

A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.

Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

Antibodies obtained from a single clone of cells grown in mice or rats.

Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.

An abundant lysosomal-associated membrane protein that has been found to shuttle between LYSOSOMES; ENDOSOMES; and the PLASMA MEMBRANE. Loss of expression of lysosomal-associated membrane protein 2 is associated with GLYCOGEN STORAGE DISEASE TYPE IIB.

The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).

A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.

A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.

Disorders of the nose, general or unspecified.

A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.

A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.

A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Pathological processes involving any part of the LUNG.

Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.

The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).

Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.

A surgical procedure involving the excision of the COLON and RECTUM and the formation of an ILEOANAL RESERVOIR (pouch). In patients with intestinal diseases, such as ulcerative colitis, this procedure avoids the need for an OSTOMY by allowing for transanal defecation.

A PREDNISOLONE derivative with similar anti-inflammatory action.

The return of a sign, symptom, or disease after a remission.

The processes triggered by interactions of ANTIBODIES with their ANTIGENS.

A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.

Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The presence of organisms, or any foreign material that makes a drug preparation impure.

A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.

Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

Therapeutic act or process that initiates a response to a complete or partial remission level.

Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.

A decrease in the number of NEUTROPHILS found in the blood.

Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.

Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).

An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.

Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.

Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.

Elements of limited time intervals, contributing to particular results or situations.

Bleeding or escape of blood from a vessel.

Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.

Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).

Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.

A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.

Pathological processes of the KIDNEY or its component tissues.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

Substances that are recognized by the immune system and induce an immune reaction.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.

The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.

Established cell cultures that have the potential to propagate indefinitely.

Substances elaborated by bacteria that have antigenic activity.

The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)

Therapy with two or more separate preparations given for a combined effect.

Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).

Proteins prepared by recombinant DNA technology.

A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.

Partial immunoglobulin molecules resulting from selective cleavage by proteolytic enzymes or generated through PROTEIN ENGINEERING techniques.

The sum of the weight of all the atoms in a molecule.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Substances elaborated by viruses that have antigenic activity.

Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.

Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

Sensitive tests to measure certain antigens, antibodies, or viruses, using their ability to agglutinate certain erythrocytes. (From Stedman, 26th ed)

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.

That region of the immunoglobulin molecule that varies in its amino acid sequence and composition, and comprises the binding site for a specific antigen. It is located at the N-terminus of the Fab fragment of the immunoglobulin. It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions.

EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.

Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Techniques used to demonstrate or measure an immune response, and to identify or measure antigens using antibodies.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Techniques for removal by adsorption and subsequent elution of a specific antibody or antigen using an immunosorbent containing the homologous antigen or antibody.

Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.

Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis. (1/823)

We describe a patient who presented with Wegener's granulomatosis associated with antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) with a cytoplasmic immunofluorescence pattern (cANCA), whose ANCA type changed to antimyeloperoxidase antibodies with a perinuclear immunofluorescence pattern (pANCA) when treated with propylthiouracil, and changed back to anti-PR3 antibodies with cANCA after the medication was discontinued. The patient developed flares of vasculitis symptoms associated with rises in either type of ANCA. Tests for antimyeloperoxidase ANCA were repeatedly negative before the drug was started, strongly implicating the drug as the cause of the episode. This case demonstrates that patients with idiopathic ANCA-positive vasculitis may quickly develop a superimposed drug-associated ANCA-positive vasculitis. Iatrogenic vasculitis should be suspected when a patient with idiopathic vasculitis with one type of ANCA develops the other type of ANCA. (+info)

Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. (2/823)

BACKGROUND: In neutrophil trafficking, the role of interleukin-8 (IL-8) is location dependent. Tissue IL-8 directs transmigration, whereas intravascular IL-8 frustrates this process. The bystander damage of glomerular endothelium by antineutrophil cytoplasmic autoantibody (ANCA)-activated neutrophils is believed to be an early event in the pathogenesis of ANCA-associated glomerulonephritis. We have studied the role of IL-8 in this process. METHODS: Intraglomerular expression of IL-8 in patients with ANCA-associated glomerulonephritis was studied by in situ hybridization and immunohistochemistry and location of neutrophils by serial section immunohistochemistry. In vitro, we analyzed ANCA-stimulated neutrophil IL-8 production by enzyme-linked immunosorbent assay, and the IL-8 attributable effect of ANCA-stimulated neutrophil supernatant by chemotactic and transendothelial assays. RESULTS: There was intraglomerular expression of IL-8 at segmental, crescentic, and parietal epithelial sites. IL-8 protein expression colocalized to intraglomerular neutrophils; many localized within glomerular capillary loops, suggesting failed trafficking to tissue IL-8. ANCAs differentially stimulated time- and dose-dependent neutrophil IL-8 production, and ANCA-stimulated neutrophil supernatant demonstrated potent IL-8-dependent chemotactic activity and inhibited transendothelial migration of normal human neutrophils toward an IL-8 gradient. CONCLUSION: Despite heavy tissue expression of IL-8 in ANCA-associated GN, the production of IL-8 by ANCA-stimulated neutrophils within the intravascular compartment may frustrate neutrophil transmigration, encourage intravascular stasis, and contribute to bystander damage of glomerular endothelial cells. (+info)

Prominence of cell-mediated immunity effectors in "pauci-immune" glomerulonephritis. (3/823)

The majority of patients with rapidly progressive crescentic glomerulonephritis show histologic features of extensive necrosis and focal and segmental proliferation with fibrin production, but little or absent Ig deposition in the glomerulus. This subcategory of the disease, labeled "pauci-immune" glomerulonephritis, has recently been shown to be associated with the presence of antineutrophil cytoplasmic antibody in the patient's circulation (but not within the glomerulus). The absence of the effectors of humoral immunity at the site of renal injury led to this investigation of the contribution of cell-mediated immunity to the glomerular injury in this form of glomerulonephritis. In 15 patients presenting acutely with pauci-immune glomerulonephritis, CD3-positive T cells (3.7+/-2.5 [mean +/- SD] cells per glomerular cross section, [c/gcs]), CD45RO-positive T cells (2.7+/-1.9 c/cgs), macrophages (7.3+/-6.1 c/gcs), fibrin (3+), and endothelial-associated tissue factor were demonstrated to be prominent in glomeruli. These mediators were absent in a group of 12 patients with thin basement membrane disease and only occasionally observed in a group of eight patients with "humorally mediated"(noncrescentic) glomerulonephritis. Thus, in pauci-immune glomerulonephritis, there is the development of significant cell-mediated immunity with activated T cells, macrophages, tissue factor, and fibrin at the site of glomerular injury, suggesting that this glomerular disease is most likely a manifestation of T cell-directed cognate immune injury. (+info)

Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. (4/823)

OBJECTIVE: To retrospectively analyze the clinical symptoms, laboratory findings, and outcomes in patients with microscopic polyangiitis (MPA) who were enrolled in various clinical trials conducted by the French Vasculitis Study Group. METHODS: A cohort of 85 patients meeting the Chapel Hill criteria for MPA participated in the study. Seventy-one of them were included in prospective therapeutic trials. Eighty-one diagnoses were biopsy proven. In the other patients, diagnosis was based on clinical findings. RESULTS: Forty-seven men and 38 women, with a mean +/- SD age of 56.8 +/- 14.6 years, met the criteria for MPA. Their main clinical symptoms were renal manifestations (78.8%), weight loss (72.9%), skin involvement (62.4%), fever (55.3%), mononeuritis multiplex (57.6%), arthralgias (50.6%), myalgias (48.2%), hypertension (34.1%), lung involvement (24.7%; alveolar hemorrhage 11.8%), and cardiac failure (17.6%). The mean +/- SD serum creatinine level before treatment was 2.59 +/- 2.96 mg/dl; 47 patients had renal insufficiency (serum creatinine > 1.36 mg/dl). Eight patients underwent dialysis at the time of diagnosis, and long-term dialysis was necessary for 10 patients. Antineutrophil cytoplasmic antibodies (ANCA) were present in 38 of 51 patients (74.5%), of whom 33 had a perinuclear staining pattern (pANCA) and 5 had a cytoplasmic pattern. Antibodies to proteinase 3 were present in 4 patients and antibodies to myeloperoxidase were detected in 31, as determined by enzyme-linked immunosorbent assay. Of the 30 patients who underwent renal and celiac angiography, 4 had microaneurysms. Of the 29 patients (34.1%) who had relapses, 8 died during or after the relapse. During followup, 28 of the 85 patients (32.9%) died. The mean +/- SD duration of followup of the group was 69.9 +/- 60.6 months. Deaths were less frequent when patients had been treated with steroids and immunosuppressive drugs (13 patients [24.1%]) than with steroids alone (15 patients [48.4%]) (P < 0.01). The 5-year survival rate was 74%. CONCLUSION: This study demonstrated that MPA is a multisystemic disease in which renal symptoms are frequent, but the disease is also associated with general symptoms, arthritis, mononeuritis multiplex, and other manifestations that are also seen in various vasculitides. The rarity of abnormal angiogram findings and the high frequency of pANCA are characteristic of MPA. In most cases, the outcome is comparable with those of other systemic vasculitides, but relapses are frequent. (+info)

Thrombotic thrombocytopenic purpura and autoimmunity: a tale of shadows and suspects. (5/823)

BACKGROUND AND OBJECTIVE: The key pathogenic feature of TTP is the formation of platelet aggregates within the microcirculation; however, the etiology of such aggregates has been elusive for years. A large amount of evidence points to an abnormal interaction between damaged vascular endothelium and platelets, although the cause of the primary microvascular endothelial cell injury is seldom clear. The autoimmune hypothesis often recurs, and this is based on a number of observations: the claimed superiority of plasma-exchange over plasma infusion, the anecdotal report of the presence of immunocomplexes and autoantibodies in TTP patients, the efficacy of the administration of corticosteroids and other immunosuppressant agents, and the concomitant occurrence of TTP in association with autoimmune diseases, especially systemic lupus erythematosus (SLE). This review will focus on the complex relationships between TTP and humoral autoimmunity; in particular, similarities and differences between TTP, SLE and antiphospholipid (aPL) antibodies syndrome, as well as the putative role of several other antibodies directed towards endothelial cells and/or platelets, including the recently discovered anti-CD36 antibodies and antivWF-cleaving metalloprotease, will be discussed. DESIGN AND METHODS: The authors have been involved in the study and treatment of TTP and autoimmune diseases for years; furthermore, the PubMed data base of the National Library of Congress has been extensively searched using the Internet. CONCLUSIONS: Although over the years evidence has increased in favor of the autoimmune hypothesis for TTP etiopathogenesis, TTP should not yet be considered an autoimmune disease. Autoantibodies should be regarded as only one of the many different insults which can trigger microvascular thrombosis even though the autoimmune theory of the pathogenesis of TTP is gaining more and more strength. As far as concerns the relationship between TTP, SLE and aPL antibodies-related disorders, these diseases should be distinguished on the basis of both different clinical presentations and accurate antibody screening, although this approach should definitely not delay the prompt start of treatment. (+info)

Wegener's granulomatosis associated with renal cell carcinoma. (6/823)

OBJECTIVE: To determine the frequencies and types of malignant neoplasms occurring before or simultaneously with the diagnosis of Wegener's granulomatosis (WG), and to test for the presence of "Wegener's autoantigen," proteinase 3 (PR3), in malignant tissues from WG patients to ascertain whether an association exists between malignancy and WG. METHODS: A retrospective statistical analysis was performed on the medical records of 477 patients with WG as compared with a control group of 479 patients with rheumatoid arthritis (RA). A murine monoclonal antibody was used to test malignant tissues for the presence of PR3. RESULTS: A malignant neoplasm was found in 23 patients in the WG group and in 18 patients in the control group. The odds ratio for malignant neoplasm in the WG group was 1.79 (P = 0.0876, 95% confidence interval [95% CI] 0.92-3.48). Seven patients with renal cell carcinoma were found in the WG group compared with 1 patient in the control group, for an odds ratio of 8.73 (P = 0.0464, 95% CI 1.04-73.69). Simultaneous occurrence of cancer and WG was observed in 14 patients with WG compared with 1 control patient, for an odds ratio of 18.00 (P = 0.0059, 95% CI 230-140.67). Furthermore, the diseases occurred simultaneously in 5 of the 7 patients with both WG and renal cell carcinoma, but not in the single patient in the control group with RA and renal cell carcinoma. PR3 could not be detected in any of the 8 malignant tissue samples (4 renal cell carcinomas) investigated in the patients from the WG group. CONCLUSION: The close temporal association between renal cell carcinoma and WG suggests that malignancy is, in some cases, a trigger for the development of WG. However, since PR3 was not found in malignant tissues from the WG patients, the immunopathologic mechanisms leading to autoimmunity and vasculitis remain unclear. (+info)

Expression of major histocompatibility class II antigens on polymorphonuclear neutrophils in patients with Wegener's granulomatosis. (7/823)

BACKGROUND: Wegener's granulomatosis is a systemic inflammatory disease of unknown etiology. Many studies suggest that autoimmune reactions are involved, and there is good evidence for the participation of immunocompetent cells. In that context, we examined the activation of polymorphonuclear neutrophils (PMNs) of patients with Wegener's granulomatosis. METHODS: In a prospective study, the expression on the surface of PMNs of CD64 and of the major histocompatibility class II (MHC II) antigen was measured by cytofluorometry in whole blood. The expression of those antigens was correlated to disease activity. RESULTS: Up to 15% of the peripheral PMNs of patients with active disease expressed MHC II. Follow-up studies showed that expression correlated closely with disease activity and that it decreased rapidly under immunosuppressive therapy. Expression of CD64 was seen in approximately 50% of the patients, regardless of disease activity. CONCLUSION: MHC II expression on PMNs might serve as a novel diagnostic marker for active disease and appears to be suitable for monitoring immunotherapy. Moreover, our data provide evidence that PMNs, which are normally MHC II negative, acquire MHC II antigens in the course of disease and may be an unrecognized function within the afferent limb of the immune response. (+info)

Definition of ocular antigens in ciliary body and retinal ganglion cells by the marker antibody pANCA. (8/823)

PURPOSE: A subset of patients with anterior uveitis express the marker, perinuclear anti-neutrophil cytoplasmic antibody (pANCA). In this study, recombinantly isolated pANCA monoclonal antibodies were used to search for ocular cells expressing the pANCA antigen. METHODS: Paraffin sections of human ocular tissues obtained after death were analyzed by immunohistochemistry to identify cell types expressing pANCA antigen. Microdissected eye-bank ocular tissue was characterized by western blot analysis to confirm antigen expression and identify candidate protein species. RESULTS: Immunohistochemical analysis with pANCA monoclonal antibodies revealed cytoplasmic antigen expression in retinal ganglion cells and ciliary body epithelium. pANCA antigen expression was restricted to tissues bearing these cell types by western blot analysis. A common set of epitope-positive protein species was shared by the two tissues (28 kDa, 80 kDa, and 90 kDa). Comparison of ocular tissues from seven subjects revealed no heterogeneity in antigen expression. CONCLUSIONS: In this study, novel cytoplasmic antigens of the pANCA marker antibody expressed in ciliary body and retinal tissue were identified. Validation of these antigens as targets of inflammation in pANCA+ uveitis requires further biochemical and immunologic analysis. (+info)

Sinclair, D; Stevens, JM (Sep 2007). "Role of antineutrophil cytoplasmic antibodies and glomerular basement membrane antibodies ... Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the ... images of pANCA and cANCA fluorescence images of ANCA Anti-Neutrophil+Cytoplasmic+Antibody at the US National Library of ... Savige, J; Davies, D; Falk, RJ; Jennette, JC; Wiik, A (Mar 2000). "Antineutrophil cytoplasmic antibodies and associated ...

https://en.wikipedia.org/wiki/Anti-neutrophil_cytoplasmic_antibody

"Antineutrophil Cytoplasmic Antibodies Associated With Infective Endocarditis". Medicine (Baltimore). 95 (3): e2564. doi:10.1097 ...

https://en.wikipedia.org/wiki/Splenic_infarction

Determination of anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and ... It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in GPA. ... Millet, A; Pederzoli-Ribeil, M; Guillevin, L; Witko-Sarsat, V; Mouthon, L (August 2013). "Antineutrophil cytoplasmic antibody- ... Seo P, Stone JH (July 2004). "The antineutrophil cytoplasmic antibody-associated vasculitides". The American Journal of ...

https://en.wikipedia.org/wiki/Granulomatosis_with_polyangiitis

Antineutrophil cytoplasmic antibody may suggest granulomatosis with polyangiitis, microscopic polyangiitis, eosinophilic ... Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a ... A systematic review of antineutrophil cytoplasmic antibody-positive vasculitis identified best treatments depending on whether ... Almost all patients with granulomatosis with polyangiitis have c-antineutrophil cytoplasmic antibody, but not vice versa. ...

https://en.wikipedia.org/wiki/Systemic_vasculitis

Millet A, Pederzoli-Ribeil M, Guillevin L, Witko-Sarsat V, Mouthon L (2013) Antineutrophil cytoplasmic antibody-associated ... Other possible findings are elevated antineutrophil cytoplasmic antibody (ANCA) levels and hematuria. Other organ functional ... Several of these vasculitides are associated with antineutrophil cytoplasmic antibodies. These are: Granulomatosis with ... In these cases, the antibody found is sometimes used in classification, as in ANCA-associated vasculitides. Clinical studies ...

https://en.wikipedia.org/wiki/Vasculitis

... , or MPO-ANCA, or perinuclear anti-neutrophil cytoplasmic antibodies, are antibodies that stain the material around the ... They are a special class of anti-neutrophil cytoplasmic antibodies. This pattern occurs because the vast majority of the ... Focal necrotizing and crescentic glomerulonephritis Rheumatoid arthritis C-ANCA Anti-neutrophil cytoplasmic antibody (ANCA) ... Antibody staining therefore results in fluorescence of the region around the nucleus. p-ANCAs stain the perinuclear region by ...

https://en.wikipedia.org/wiki/P-ANCA

"Anti-Saccharomyces cerevisiae and antineutrophil cytoplasmic antibodies as predictors of inflammatory bowel disease". Gut. 54 ( ... Both the endomysial antibody and tissue transglutaminase antibody have very high sensitivities (93% for both) and specificities ... 266-7. ISBN 978-0-19-856837-7. MacDonald JK, Nguyen TM, Khanna R, Timmer A (November 2016). "Anti-IL-12/23p40 antibodies for ... Kaila B, Orr K, Bernstein CN (December 2005). "The anti-Saccharomyces cerevisiae antibody assay in a province-wide practice: ...

https://en.wikipedia.org/wiki/Crohn's_disease

Zhang J, Zhang HY, Chen SZ, Huang JY (2016). "Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and ... elevated blood levels of IgM antibodies, and clonal expansion of T cells. Similar to lymphocyte=variant hypereosinophilia, the ...

https://en.wikipedia.org/wiki/Eosinophilia

A1-B58 haplotype (A1-B17 where B58 is dominant) may remain associated with anti-neutrophil cytoplasmic antibody (ANCA) With the ... "Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India". J ... The serotype is determined by the antibody recognition of α1 subset of HLA-A α-chains. For A1, the alpha "A" chain are encoded ...

https://en.wikipedia.org/wiki/HLA-A1

Bosch X, Guilabert A, Espinosa G, Mirapeix E (August 2007). "Treatment of antineutrophil cytoplasmic antibody associated ... Two pathological subsets of EGPA are differentiated by the presence of antineutrophil cytoplasmic antibodies (ANCA), ... Diagnostic markers include eosinophil granulocytes and granulomas in affected tissue, and antineutrophil cytoplasmic antibodies ... Mepolizumab is a monoclonal antibody that targets interleukin-5, a major factor in eosinophil survival. In addition to ...

https://en.wikipedia.org/wiki/Eosinophilic_granulomatosis_with_polyangiitis

Antibodies are also known as anti-neutrophil cytoplasmic antibodies (ANCAs), though ANCAs have also been detected in staining ... Flint SM, McKinney EF, Smith KG (Mar 2015). "Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody- ... Antibodies against MPO have been implicated in various types of vasculitis, most prominently three clinically and ... Leong AS, Cooper K, Leong, FJ (2003). Manual of Diagnostic Antibodies for Immunohistology. London: Greenwich Medical Media. pp ...

https://en.wikipedia.org/wiki/Myeloperoxidase

IgA and anti-neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3-ANCA): antibodies to predict severe disease, poor ... For example, approximately 80% of people with PSC have perinuclear antineutrophil cytoplasmic antibodies (P-ANCA); however, ... Antinuclear antibodies and anti-smooth muscle antibody are found in 20-50% of PSC patients, and likewise are not specific for ... An IgA isotype autoantibody to the pancreatic GP2 protein (anti-GP2 IgA antibody) is the first verified prognostic biomarker in ...

https://en.wikipedia.org/wiki/Primary_sclerosing_cholangitis

Specifically, perinuclear antineutrophil cytoplasmic antibodies (pANCA) are found in 70 percent of cases of UC. Antibodies ... Etrolizumab is a humanized monoclonal antibody that targets he β7 subunit of integrins α4β7 and αEβ7. Etrolizumab decreases ... Specific antibody markers may be elevated in ulcerative colitis. ...

https://en.wikipedia.org/wiki/Ulcerative_colitis

Anti-neutrophil cytoplasmic antibodies (ANCAs) are associated with AS, but do not correlate with disease severity. Single ... The body produces antibodies that attack Klebsiella pneumoniae. Enzymes made by the bacterium resemble human proteins, ... The antibodies therefore attack these human proteins, producing the symptoms of ankylosing spondylitis. Ebringer and others ... AS is a type of seronegative spondyloarthropathy, meaning that tests show no presence of rheumatoid factor (RF) antibodies. ...

https://en.wikipedia.org/wiki/Ankylosing_spondylitis

... s, or PR3-ANCA, or antineutrophil cytoplasmic antibodies, are a type of autoantibody, an antibody produced by the body ... P-ANCA Anti-Neutrophil Cytoplasmic Antibody (ANCA) Thomas M. Habermann (26 June 2006). Mayo Clinic internal medicine review, ... These antibodies show a diffusely granular, cytoplasmic staining pattern under microscopy. This pattern results from binding of ...

https://en.wikipedia.org/wiki/C-ANCA

... perinuclear anti-neutrophil cytoplasmic antibody) in ulcerative colitis". Journal of Immunology. 156 (10): 4005-11. PMID ...

https://en.wikipedia.org/wiki/GJB6

It is thought that antineutrophil cytoplasmic antibodies (ANCA) interact with antigens in the cytoplasm of neutrophils to cause ... and type III and idiopathic RPGN are frequently associated with anti-neutrophil cytoplasmic antibodies (ANCA)-positive serum. ... The presence of anti-glomerular basement membrane (GBM) antibodies suggests type I RPGN; antinuclear antibodies (ANA) may ... The majority of type I disease, however, features anti-GBM antibodies alone; these cases are considered idiopathic. ...

https://en.wikipedia.org/wiki/Rapidly_progressive_glomerulonephritis

... proliferative nephritis is associated with antineutrophil cytoplasmic antibodies (ANCA). Because of this, an ANCA test should ...

https://en.wikipedia.org/wiki/Pauci-immune

ASCAs and perinuclear antineutrophil cytoplasmic antibodies (pANCAs) are the two most useful and often discriminating ... 2007). "Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies ... Anti-Saccharomyces cerevisiae antibodies (ASCAs) are antibodies against antigens presented by the cell wall of the yeast ... ASCA antibodies react to a yeast protein with mannans, a 200-kDa glycoprotein. Diseases in which ASCA are found include the ...

https://en.wikipedia.org/wiki/Anti–Saccharomyces_cerevisiae_antibody

... in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Treated Concomitantly With Rituximab or ... in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis". ACR Open Rheumatol. 2 (11): 662-671. doi:10.1002/ ... In the United States, avacopan is indicated as an adjunctive treatment of adults with severe active anti-neutrophil cytoplasmic ... Avacopan, sold under the brand name Tavneos, is a medication used to treat anti-neutrophil cytoplasmic autoantibody-associated ...

https://en.wikipedia.org/wiki/Avacopan

... anti-neutrophil cytoplasmic antibody-induced release of chemotaxins". Journal of Immunology. 171 (11): 6090-6. doi:10.4049/ ...

https://en.wikipedia.org/wiki/FCGR3B

Antineutrophil cytoplasmic antibody (ANCA) - If positive, this indicates that there is likely an underlying vasculitis that may ... Cryoglobulinemia - Antibodies that are sensitive to the cold can become activated in cold conditions and cause an increase in ... Most often, it is dependent on what part of the glomerulus is damaged by antibody-antigen complex (immune complex) deposition. ... Serum complement (C3 and C4) - Complement factors bind to antibodies to form immune complexes and a decreased serum complement ...

https://en.wikipedia.org/wiki/Nephritic_syndrome

It is not associated with anti-neutrophil cytoplasmic antibodies, unlike other vasculitic disorders associated with them (such ... Rowley AH, Baker SC, Orenstein JM, Shulman ST (May 2008). "Searching for the cause of Kawasaki disease-cytoplasmic inclusion ...

https://en.wikipedia.org/wiki/Kawasaki_disease

It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of ... Ohlsson K, Linder C, Rosengren M (July 1990). "Monoclonal antibodies specific for neutrophil proteinase 4. Production and use ... antibody frequently found in the disease granulomatosis with polyangiitis. ENSG00000196415 GRCh38: Ensembl release 89: ...

https://en.wikipedia.org/wiki/Proteinase_3

... smooth muscle antibody (SMA), and atypical perinuclear antineutrophil cytoplasmic antibody (p-ANCA). Other autoantibodies that ... anti-viral antibodies (such as the anti-hepatitis B surface antibody or anti-hepatitis A antibody), or viral DNA/RNA. In early ... Auto-antibodies found in patients with autoimmune hepatitis include the sensitive but less specific anti-nuclear antibody (ANA ... Therefore, when a patient is positive for IgG antibody but negative for IgM antibody, he is considered immune from the virus ...

https://en.wikipedia.org/wiki/Hepatitis

Antinuclear antibodies are usually positive in drug-induced Lupus. Anti-Neutrophil Cytoplasmic antibodies (ANCA) can also be ... Furthermore, anti-histone antibodies can also be positive in drug-induced lupus.[citation needed] Anti-Histone antibodies are ... Anti-histone antibodies in 95% of cases among those taking procainamide, hydralazine, chlorpromazine, and quinidine; however, ... Corticosteroids may be used if more severe symptoms of DIL are present.[citation needed] Anti-histone antibody Lupus ...

https://en.wikipedia.org/wiki/Drug-induced_lupus_erythematosus

Perinuclear pattern of antineutrophil cytoplasmic antibodies (p-ANCA) - not associated with "classic" polyarteritis nodosa, but ... and pericarditis Intestinal necrosis and perforation PAN has no association with anti-neutrophil cytoplasmic antibodies, but ... for surface antigen or antibody) Arteriogram (angiogram) showing the arteries that are dilated (aneurysms) or constricted by ...

https://en.wikipedia.org/wiki/Polyarteritis_nodosa

... and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides such as granulomatosis with polyangiitis (GPA), ...

https://en.wikipedia.org/wiki/Vasculitic_neuropathy

Perinuclear Anti-Neutrophil Cytoplasmic Antibodies Pânca, Bucerdea Grânoasă a village in Romania Panka, Ukraine, a village in ...

https://en.wikipedia.org/wiki/Panca

An important diagnostic test is the presence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) with myeloperoxidase ... October 2002). "Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis ... These antibodies will circulate at low levels until a pro-inflammatory trigger-such as infection, malignancy, or drug therapy. ... Then, the large number of antibodies make it more likely that they will bind a neutrophil. Once bound, the neutrophil ...

https://en.wikipedia.org/wiki/Microscopic_polyangiitis

... antibodies, antineutrophil cytoplasmic MeSH D12.776.377.715.548.114.323.204 - antibodies, antinuclear MeSH D12.776.377.715. ... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... antibodies, bispecific MeSH D12.776.377.715.548.114.143 - antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, ... antibodies, helminth MeSH D12.776.377.715.548.114.191 - antibodies, heterophile MeSH D12.776.377.715.548.114.224 - antibodies, ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)

Falk studies kidney diseases caused by anti-neutrophil cytoplasmic autoantibodies, which are a major cause for the most common ... This restricted MPO region was targeted by both T cells and antibodies but is not accessible to solvent or chemical ... Falk, R. J.; Terrell, R. S.; Charles, L. A.; Jennette, J. C. (1990-06-01). "Anti-neutrophil cytoplasmic autoantibodies induce ... Falk, Ronald J.; Jennette, J. Charles (1988-06-23). "Anti-Neutrophil Cytoplasmic Autoantibodies with Specificity for ...

https://en.wikipedia.org/wiki/Ronald_J._Falk

... antibodies, antineutrophil cytoplasmic MeSH D12.776.124.486.485.114.323.204 - antibodies, antinuclear MeSH D12.776.124.486. ... antibodies, antineutrophil cytoplasmic MeSH D12.776.124.790.651.114.323.204 - antibodies, antinuclear MeSH D12.776.124.790. ... antibodies MeSH D12.776.124.486.485.114.071 - antibodies, anti-idiotypic MeSH D12.776.124.486.485.114.089 - antibodies, ... antibodies, bispecific MeSH D12.776.124.486.485.114.143 - antibodies, blocking MeSH D12.776.124.486.485.114.167 - antibodies, ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)

Australian manufacturing company Anti-neutrophil cytoplasmic antibody, proteins detected in a number of autoimmune disorders C- ...

https://en.wikipedia.org/wiki/ANCA

ChemoCentryx is the maker of Tavneos-a drug treatment for rare diseases called anti-neutrophil cytoplasmic autoantibody- ... In June 2015, Amgen presented Phase II clinical trial data for their anti-CGRP antibody AMG 334 for migraine, approved for sale ... "Amgen bets up to $1.7B on Xencor's antibody technology". FierceBiotech. 16 September 2015. "Amgen, Xencor to Partner on Cancer ... "New Data on CGRP Monoclonal Antibodies for Migraine Prevention". Medscape. Lisa Astor (September 9, 2019). "FDA Grants AMG 510 ...

https://en.wikipedia.org/wiki/Amgen

The Jo-1 antigen and antibody were characterised in 1980. Anti-neutrophil cytoplasmic antibody (ANCA) Rheumatoid factor " ... anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to ... This pattern is associated with anti-dsDNA antibodies, antibodies to nucleosomal components, and anti-histone antibodies. There ... Although anti-Jo-1 antibodies are often included with ANAs, they are actually antibodies to the cytoplasmic protein, Histidyl- ...

https://en.wikipedia.org/wiki/Antinuclear_antibody

This test looks for antineutrophil cytoplasmic antibodies (ANCA) in your blood. If ANCAs are found, you may have autoimmune ... What is an antineutrophil cytoplasmic antibodies (ANCA) test?. This test looks for antineutrophil cytoplasmic antibodies (ANCA ... medlineplus.gov/lab-tests/antineutrophil-cytoplasmic-antibodies-anca-test/ Antineutrophil Cytoplasmic Antibodies (ANCA) Test. ... Antineutrophil Cytoplasmic Antibodies (ANCA). Autoimmunity [Internet]. 2005 Feb [cited 2019 May 3]; 38(1): 93-103. Available ...

https://medlineplus.gov/lab-tests/antineutrophil-cytoplasmic-antibodies-anca-test/

Objective: Prediction of relapses in Wegeners granulomatosis (WG) by measuring levels of antineutrophil cytoplasmic antibodies ... Prediction of relapses in Wegeners granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective ... The predictive value of an increase in ANCA titers for relapse was 57% (17 of 30) for cytoplasmic/classic ANCA (cANCA; by IIF ... Antibodies, Antineutrophil Cytoplasmic / blood* * Antibodies, Antineutrophil Cytoplasmic / immunology * Antibody Specificity * ...

https://pubmed.ncbi.nlm.nih.gov/11014352/?dopt=Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated ILD (ANCA-ILD) patients prevalence, clinical characteristics, AE risk ... Acute Exacerbation of Interstitial Lung Disease Associated with Antineutrophil Cytoplasmic Antibodies. Oct 31, 2022 ...

https://www.physiciansweekly.com/acute-exacerbation-of-interstitial-lung-disease-associated-with-antineutrophil-cytoplasmic-antibodies/

... A ELISA Kit - Gentaur.com - Product info ... Human Perinuclear anti-neutrophil cytoplasmic antibody, pANCA ELISA Kit[Perinuclear anti-neutrophil cytoplasmic antibody, pANCA ... Ask Antibody, Rabbit, anti-, ELISA, anti, antibody to, antibodies, antibodies against human proteins, antibodies for, ELISAs ... Antibody, Rabbit, anti-, ELISA, anti, antibody to, antibodies, antibodies against human proteins, antibodies for, ELISAs Enzyme ...

https://gentaur.com/enlibio/rabbit-perinuclear-anti-neutrophil-cytoplasmic-antibodypancaelisakit-01017007333

This affordable and painless test detects the levels of Antineutrophil cytoplasmic antibodies in the blood. Place your order at ...

https://www.personalabs.com/product/antineutrophil-cytoplasmic-antibody-anca-profile-blood-test/

... for systemic vasculitis is less established than that for cytoplasmic antineutrophil cytoplasmic antibody (cANCA)/ ... Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on ... Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on ... Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on ...

https://www.jrheum.org/content/28/7/1584

Prognostic value of peri-nuclear Anti Neutrophil Cytoplasmic Antibodies in subjects with primary sclerosing cholangitis. In: ... OBJECTIVE: To evaluate the prognostic value of peri-nuclear Anti- Neutrophil Cytoplasmic Antibodies (p-ANCA) in subjects with ... Dive into the research topics of Prognostic value of peri-nuclear Anti Neutrophil Cytoplasmic Antibodies in subjects with ... N2 - OBJECTIVE: To evaluate the prognostic value of peri-nuclear Anti- Neutrophil Cytoplasmic Antibodies (p-ANCA) in subjects ...

https://moh-it.pure.elsevier.com/en/publications/prognostic-value-of-peri-nuclear-anti-neutrophil-cytoplasmic-anti

Antineutrophil cytoplasmic antibody. Occasionally, patients are found with positive test results for perinuclear antineutrophil ... cytoplasmic (p-ANCA) antibody. However, positive or negative results on this test do not change prognosis or therapy. ... Although such antibodies are uncommon in Behçet disease, they are worth investigating to rule out alternate causes of ... Therefore, antiphospholipid antibodies and other causes of hypercoagulability should be ruled out as contributing factors to ...

https://www.medscape.com/answers/329099-168604/what-is-the-role-of-a-pathergy-test-in-the-workup-of-behet-disease

Nonlinear pharmacokinetics of rituximab in anti-neutrophil cytoplasmic antibody associated vasculitis. Denis Mulleman 1, 2 ... Nonlinear pharmacokinetics of rituximab in anti-neutrophil cytoplasmic antibody associated vasculitis.. EULAR 2019, Jun 2019, ...

https://hal.univ-brest.fr/hal-02151041

Cytoplasmic-anti-neutrophil cytoplasmic antibodies targeting myeloperoxidase in Wegeners granulomatosis: A rare phenomenon. ... Cytoplasmic antineutrophil cytoplasmic antibodies. immunofluorescence. myeloperoxidase. Wegeners granulomatosis. Issue Date: ... Cytoplasmic-anti-neutrophil cytoplasmic antibodies targeting myeloperoxidase in Wegeners granulomatosis: A rare phenomenon. ... Wegeners granulomatosis (WG) patients can rarely have antineutrophil cytoplasmic antibodies (ANCAs) directed against ...

https://imsear.searo.who.int/handle/123456789/156090

keywords = "Antineutrophil cytoplasmic antibody-associated vasculitis, Biomarkers, Eosinophilic granulomatosis with ... identify circulating biomarkers for prediction of disease activity and organ involvement in antineutrophil cytoplasmic antibody ... identify circulating biomarkers for prediction of disease activity and organ involvement in antineutrophil cytoplasmic antibody ... identify circulating biomarkers for prediction of disease activity and organ involvement in antineutrophil cytoplasmic antibody ...

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Access 704 top medical experts on Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis across 46 countries and 32 U.S. ... 704 top medical experts on Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis across 46 countries and 32 U.S. states, ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Group of systemic vasculitis with a strong association with anca. ... Find Expert Doctors on Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. Based on Scientific Publications, NIH Grants ...

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ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES AFTER LIVER-TRANSPLANTATION FOR PRIMARY SCLEROSING CHOLANGITIS BANSI D., GUNSON B., ...

https://www.expmedndm.ox.ac.uk/publications/171795?133fe006-6f9f-11ed-8565-061b866677b4

Physicians perceptions about antineutrophil cytoplasmic antibody-associated vasculitis: an online survey…. Physicians ...

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Antineutrophil cytoplasmic antibody levels. * Salivary flow. * Schirmer blotting test. * Nerve excitability test ... Rapid plasma reagin and/or venereal disease research laboratory test or fluorescent treponemal antibody absorption test ...

https://emedicine.medscape.com/article/1146903-overview

PR3-anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis. Michael Mahler, Jan Damoiseaux, Vera Ballet, Doreen ... Background: Antibodies directed against dsDNA are a highly specific diagnostic marker for the presence of systemic lupus ... Some antinuclear antibodies (ANA) pattern, detected by indirect immunofluorescence (IIF), such as multiple nuclear dot (MND) ... To assess anti-dsDNA antibodies, the Crithidia luciliae -based indirect immunofluorescence test (CLIFT) is one of the assays ...

https://www.degruyter.com/journal/key/cclm/56/1/html

Order Human proteinase-antineutrophil cytoplasmic antibody PR3-ANCA ELISA Kit 01012357886 at Gentaur proteinase-antineutrophil ... If you buy Antibodies supplied by bioassay they should be stored frozen at - 24°C for long term storage and for short term at ... cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies ...

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High proteinase 3-anti-neutrophil cytoplasmic antibody (ANCA) level measured by the capture enzyme-linked immunosorbent assay ... Positive classic antineutrophil cytoplasmic antibody (C-ANCA) titer at switch to azathioprine therapy associated with relapse ... Outcome of renal replacement therapy in antineutrophil cytoplasmic antibody-associated systemic vasculitis. J Am Soc Nephrol ... Predictors of relapse and treatment resistance in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis. Ann ...

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Antineutrophil cytoplasmic autoantibody (ANCA) vasculitis: Specific antibodies called ANCAs cause inflammation by attaching to ... IgA vasculitis (Henoch-Schönlein purpura): An antibody called immunoglobulin A clusters in the small blood vessels. These ...

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Sinobronchial syndrome Diffuse panbronchiolitis (DPB) MPO-ANCA-related vasculitis Antineutrophil cytoplasmic antibody against ... A case of sinobronchial syndrome complicated with myeloperoxidase-specific antineutrophil cytoplasmic antibody-related ...

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Antineutrophil cytoplasmic antibody (ANCA) Use the purified protein derivative test to evaluate for exposure to tuberculosis. ( ... Use antinuclear antibody reflexive panel, rheumatoid factor, and antiphospholipid antibodies (if history of thrombosis is found ... Antibodies to type II collagen in relapsing polychondritis. N Engl J Med. 1978 Nov 30. 299(22):1203-7. [QxMD MEDLINE Link]. ... Piette JC, El-Rassi R, Amoura Z. Antinuclear antibodies in relapsing polychondritis. Ann Rheum Dis. 1999 Oct. 58(10):656-7. [ ...

https://emedicine.medscape.com/article/331475-workup

What is Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis?. Related Articles. Mind-Altering Substances ...

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Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) represents one of the most challenging and potentially life- ... Steroid-free management and recent advances in antineutrophil cytoplasmic antibody-associated vasculitis. Hassan Malik1, Renuka ...

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Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese ... Dive into the research topics of Histopathological classification of anti-neutrophil cytoplasmic antibody-associated ...

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Propylthiouracil-induced anti-neutrophil cytoplasmic antibodies positive vasculitis. Alves Marta , Neves Celestino , Magalhaes ... namely the antibody production. Aim of the present study was to evaluate the effect of RTX on serum TSH-receptor antibodies, ... The TSH receptor antibody levels (TSHRAb) and thyroid function after 131I therapy in patients with Graves disease 10 years ... Long-term follow-up of antithyroid peroxidase antibodies in patients with Hashimoto s thyroiditis. Agbaht Kemal , Dagdelen ...

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Antineutrophil cytoplasmic antibodies (ANCA) had been sought in 72/115 patients. The technique used followed the ... Abbreviations: ab = antibodies, ACR = American College of Rheumatology, ag = antigen, ANCA = antineutrophil cytoplasmic ... Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR ... antineutrophil cytoplasmic antibodies (ANCA) are not detected; relapses are rare, and never occur once viral replication has ...

https://journals.lww.com/md-journal/Fulltext/2005/09000/Hepatitis_B_Virus_Associated_Polyarteritis_Nodosa_.6.aspx

Antiglomerular basement membrane antibody. *Antineutrophil cytoplasmic antibody for vasculitis (ANCA). *Blood culture ... IgA nephropathy (disorder in which antibodies called IgA build up in kidney tissue) ...

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Three months earlier, p-ANCA/MPO-positive (ANCA, antineutrophil cytoplasmic antibody; MPO, myeloperoxidase), rapidly ... Three months earlier, p-ANCA/MPO-positive (ANCA, antineutrophil cytoplasmic antibody; MPO, myeloperoxidase), rapidly ...

https://www.aerzteblatt.de/int/archive/article/206818

Antineutrophil cytoplasmic antibody-positive polyarthritis associated with minocycline therapy. Gaffney, K. & Merry, P., Dec ...

https://research-portal.uea.ac.uk/en/publications/?indexableKeyword=%2Fdk%2Fatira%2Fpure%2Fsustainabledevelopmentgoals%2Fquality_education&format=&ordering=publicationYearThenTitle&descending=true&page=1210

This test looks for antineutrophil cytoplasmic antibodies (ANCA) in a sample of your blood. (medlineplus.gov)
An ANCA test can show whether you have one or both types of antibodies. (medlineplus.gov)
Prediction of relapses in Wegener's granulomatosis (WG) by measuring levels of antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) or myeloperoxidase (MPO) remains a controversial issue. (nih.gov)
Antineutrophil cytoplasmic antibody (ANCA)-associated ILD (ANCA-ILD) patients' prevalence, clinical characteristics, AE risk factors, and leading causes of mortality, however, have not been thoroughly documented. (physiciansweekly.com)
OBJECTIVE: To evaluate the prognostic value of peri-nuclear Anti- Neutrophil Cytoplasmic Antibodies (p-ANCA) in subjects with primary sclerosing cholangitis (PSC) and in particular whether it is associated with inflammatory bowel disease (IBD). (elsevier.com)
abstract = "OBJECTIVE: To evaluate the prognostic value of peri-nuclear Anti- Neutrophil Cytoplasmic Antibodies (p-ANCA) in subjects with primary sclerosing cholangitis (PSC) and in particular whether it is associated with inflammatory bowel disease (IBD).PATIENTS AND METHODS: In the last 9 years,64 patientswere admitted to our Hospital with PSC: 34 males, mean age 53 years, range 17-90. (elsevier.com)
We present to you a report of three cases of WG, demonstrating a cytoplasmic- ANCA pattern on indirect IIF, but directed against MPO. (who.int)
In this study, we used targeted serum proteomics to identify circulating biomarkers for prediction of disease activity and organ involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (elsevier.com)
Cyclophosphamide and glucocorticoids have reduced mortality in antineutrophil cytoplasm antibody (ANCA) associated vasculitides (AAV), although cure remains uncommon. (bmj.com)
ANCA: Anti-neutrophil cytoplasmic antibodies. (vasculitisfoundation.org)
Antineutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis after immunisation with bacterial proteins. (wikigenes.org)
The evaluation also revealed normal or negative tests for antinuclear antibody (ANA) and antibodies to extractable nuclear antigens (ENA), antiphospholipid antibody panel, complement levels (C3, C4), serum and urine protein electrophoresis, antineutrophil cytoplasmic antibody (ANCA) screening, viral hepatitis panel, and tests for cryoglobulins and cold agglutinins. (medscape.com)
ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA . (bvsalud.org)
In this case, a 28-year-old male presented with complaints of epistaxis and breathlessness, which was diagnosed as WG with pneumothorax on the basis of chest X-ray and computed tomography (CT) chest and pathological confirmation by high level of serum cytoplasmic antineutrophil cytoplasmic antibody (ANCA). (jacpjournal.org)

OBJECTIVE: The diagnostic value of tests for antimyeloperoxidase antibodies (anti-MPO) for systemic vasculitis is less established than that for cytoplasmic antineutrophil cytoplasmic antibody (cANCA)/antiproteinase 3 antibodies (anti-PR3). (jrheum.org)
Nonlinear pharmacokinetics of rituximab in anti-neutrophil cytoplasmic antibody associated vasculitis. (univ-brest.fr)
Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis. (bvsalud.org)
We undertook a systematic literature review as a background to the European League Against Rheumatism (EULAR) recommendations for conducting clinical trials in anti-neutrophil cytoplasm antibody associated vasculitis (AAV), and to assess the quality of evidence for outcome measures in AAV. (bmj.com)
Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) represents one of the most challenging and potentially life-threatening conditions faced by rheumatologists. (indianjrheumatol.com)
To provide evidence-based recommendations and expert guidance for the management of antineutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). (bvsalud.org)
Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitis. (cdc.gov)
Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Update: Genetic Pathogenesis. (cdc.gov)
A meta-analysis has highlighted the cardiovascular (CV) risk faced by patients with vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs). (medwirenews.com)

Wegener's granulomatosis (WG) patients can rarely have antineutrophil cytoplasmic antibodies (ANCAs) directed against myeloperoxidase (MPO), producing a cytoplasmic pattern on indirect immunofluorescence (IIF). (who.int)
Specific antibodies called ANCAs cause inflammation by attaching to immune cells called neutrophils. (uclahealth.org)
In their original description of antineutrophil cytoplasmic antibodies (ANCAs), Daives et al[1] suggested that arboviral infection-related superantigens might stimulate the production of ANCAs that attack host tissues because of molecular mimicry or some other abnormality of immune tolerance. (medscape.com)

In single antibody ELISAs the antigen is coated and only a detector antibody is used. (gentaur.com)
Traditional competition antigen ELISAs are coated with a captor antibody and a competitive antigen is labelled with the chromogen. (gentaur.com)
During an acute infection, an antibody response to C. burnetii phase II antigen is predominant and is higher than the response to the phase I antigen, whereas a chronic infection is associated with a rising phase I immunoglobulin G (IgG) titer. (cdc.gov)

IMSEAR at SEARO: Cytoplasmic-anti-neutrophil cytoplasmic antibodies targeting myeloperoxidase in Wegener's granulomatosis: A rare phenomenon. (who.int)

Use antinuclear antibody reflexive panel, rheumatoid factor, and antiphospholipid antibodies (if history of thrombosis is found) to evaluate for other autoimmune connective-tissue diseases. (medscape.com)
Antinuclear antibody and antineutrophil cytoplasmic antibody assays were negative. (who.int)

Keogh KA, Specks U. Churg-Strauss syndrome: clinical presentation, antineutrophil cytoplasmic antibodies, and leukotriene receptor antagonists. (medscape.com)
Antineutrophil cytoplasmic antibodies and associated diseases: a review of the clinical and laboratory features. (wikigenes.org)
[ 11 ] We have also demonstrated that RF positivity was associated with cutaneous manifestation in EGPA patients at the time of diagnosis, suggesting that this antibody could have clinical relevance in AAV and should be further investigated. (medscape.com)

Enlibio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. (gentaur.com)

Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES . (bvsalud.org)

Primary biliary cholangitis (PBC), also known as primary biliary cirrhosis, is an autoimmune disease of the liver characterized by anti-mitochondrial antibodies (AMA) in 90%-95% of patients. (degruyter.com)
Patients with GPA (p = 0.0045) and MPA (p = 0.005) had anti-NET IgG antibodies . (bvsalud.org)
Patients with TAK had anti- histone antibodies (p (bvsalud.org)
Patients are often positive for antineutrophil cytoplasmic antibodies. (clinicaladvisor.com)

Diagnostic performance of antineutrophil cytoplasmic antibody tests for idiopathic vasculitides: metaanalysis with a focus on antimyeloperoxidase antibodies. (jrheum.org)
Both non HBV-related PAN and HBV-related PAN are differentiated from the other small- and medium-vessel vasculitides by the absence of antineutrophil cytoplasmic antibodies, and by confirmation that small vessels (i.e., arterioles, capillaries, venules) are not involved. (bmj.com)

Monoclonal antibodies against IL-5 have been developed to target eosinophilic inflammation. (medscape.com)

Results of indirect immunoflorescent antibody (IFA) testing were positive for Leishmania parasites (titer 6,400). (cdc.gov)
The examination of Giemsa-stained smears from bone marrow aspirate demonstrated abundant Leishmania parasites, and IFA was marginally positive for Leishmania antibodies (titer 400). (cdc.gov)

Antibodies are proteins that your immune system makes to fight foreign substances, such as viruses and bacteria. (medlineplus.gov)

Q fever has acute and chronic stages that correspond to two distinct antigenic phases of antibody response. (cdc.gov)

Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long. (gentaur.com)
[ 2 ] The monoclonal antibody mepolizumab is approved for use in EGPA. (medscape.com)

Some antinuclear antibodies (ANA) pattern, detected by indirect immunofluorescence (IIF), such as multiple nuclear dot (MND) and rim-like patterns are well-known to be specific for PBC. (degruyter.com)

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. (gentaur.com)

The cryoprecipitate was isolated and found to be negative for HCV nucleic acid and antibodies. (who.int)

But sometimes antibodies attack the healthy cells of your own tissues and organs by mistake. (medlineplus.gov)

Anti-Neutrophil Cytoplasmic Antibodies Positivity and Anti-Leukotrienes in Eosinophilic Granulomatosis with Polyangiitis : a Retrospective Monocentric Study on 134 Italian Patients / J.W. Schroeder, M. Folci, L.M. Losappio, M. Chevallard, R.A. Sinico, C. Mirone, F. De Luca, M. Nichelatti, E.A. Pastorello. (unimi.it)

[ 6 , 17 ] An alternative to CYC for remission induction in patients with severe AAV began to emerge after the initial report of successful compassionate use of the anti-CD20 chimeric monoclonal antibody rituximab (RTX) in a patient with chronic relapsing GPA. (medscape.com)
Abbreviation for monoclonal antibody . (thefreedictionary.com)
1 They showed remarkable effectiveness of dupilumab, a monoclonal antibody targeting the interleukin-4 (IL-4) receptor alpha, in immunoglobulin G4-related disease (IgG4-RD) complicated with retroperitoneal fibrosis for the first time. (bmj.com)
Cyclophosphamide & Rituximab, (chimeric monoclonal antibody against B cells) thus works.T lymphocytes : granulomatous inflammation in WG with IgG1 and IgG4 subclasses, indicates involvement of T-cell, thus MMF works. (mdrenalconsult.com)

The most commonly described are anti-Saccharomyces cerevisiae mannan antibodies (ASCA) in CD and perinuclear antineutrophil cytoplasm antibodies (pANCA) in UC. (bgu.ac.il)
Others have reported positive findings for antinuclear antibodies, rheumatoid factor, perinuclear antineutrophil cytoplasmic antibodies with antimyeloperoxidase specificity, and hypocomplementemia. (medscape.com)

Prognostic factors in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with severe glomerular sclerosis: a national registry-based cohort study. (uib.no)
The present study addressed whether V-domain Ig suppressor of T cell activation (VISTA), constitutively expressed in kidney macrophages, plays a protective role in tubulointerstitial fibrotic transformation after acute antibody-mediated glomerulonephritis. (jci.org)
13 Plasma exchange was introduced for the removal of anti-glomerular basement membrane (GBM) antibodies in Goodpasture disease and used subsequently in crescentic glomerulonephritis without anti-GBM antibodies. (asnjournals.org)

Antibodies neutralize or destroy antigens in several ways. (thefreedictionary.com)
SLE is an autoimmune disease characterized by the presence of aberrant antibody responses to nuclear and cytoplasmic antigens. (biomedcentral.com)
Antibodies directed against antigens in the cytoplasm of neutrophils. (appyourself.net)

Lack of association between antiphospholipid antibodies and thrombocytopenia in patients with Wegener's granulomatosis. (thedoctorsdoctor.com)
An increased prevalence of antiphospholipid antibodies (aPL), which is associated with thrombocytopenia, has been noted in patients with WG. (thedoctorsdoctor.com)
The antibody is found in a variety of autoimmune and infectious diseases, including in patients with the antiphospholipid antibody syndrome and syphilis. (thefreedictionary.com)

Serum P/Q-type voltage-gated calcium-channel antibodies are usually present. (bmj.com)
Serum IgG2 antibody multi-composition in Systemic Lupus Erythematosus and in Lupus nephritis (Part 1). (unifi.it)
An antibody found in the serum of patients with rheumatoid arthritis but not in those with other joint or soft tissue diseases. (thefreedictionary.com)
An antibody that cross-reacts with smooth muscle collagen and the gluten in wheat, found in the serum of people with celiac sprue and some related autoimmune diseases. (thefreedictionary.com)
After admission, patient was found to have multiple metastasis of follicular thyroid cancer with lesion in the lumber spine, and his serum thyroglobulin level was elevated at 1,500 ng/mL (1.3 - 31.8 ng/mL) without thyroglobulin antibody detected. (labmedicineblog.com)
The Anti-Cytoplasmic Antibodies Igm reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (gentaurprices.com)
Since then, serum free media has become the norm and now there are new animal-free, defined supplements including recombinant proteins and purified defined plant based hydrolysates that have been shown to improve cell growth, viability, and antibody yield further. (cellculturedish.com)

B cells are the ones that make our antibodies, which, in patients with autoimmune disease, they have antibodies to self, that's what is tested for in the clinical labs. (unc.edu)

We observed in CLL a systemic immune response associated with IgA antineutrophil cytoplasmic antibodies in 73% of patients, and elevated type I interferon blood signature in comparison with healthy controls. (medscape.com)

In people with this disease, antibodies attack immune cells called neutrophils, causing inflammation in small- to medium-sized blood vessels. (nih.gov)

No matter which type of antibodies were found, you may need an additional test, known as biopsy , to confirm the diagnosis. (medlineplus.gov)

Serological markers were negative for antinuclear, anti-neutrophil cytoplasmic, antimitochondrial, and anti-smooth muscle antibodies. (aacc.org)
All virological and serological tests including hepatitis B and anti-neutrophil cytoplasmic antibody were negative. (samj.org.za)

Immunogenicity (neutralizing antibody titers and antigen specific binding antibody titers) [ Time Frame: 14 days, 28 days after each vaccination, and 180 days after second vaccination. (clinicaltrials.gov)

Therefore, VISTA is a sentinel protein expressed in kidney macrophages that prevents tubulointerstitial fibrosis via the IFN-γ/IL-9 axis after acute antibody-mediated glomerular injury. (jci.org)

The patient tested positive for hepatitis A IgG and negative for hepatitis A IgM antibodies, indicating a remote infection with hepatitis A virus. (aacc.org)

A highly specific antibody formed by a clone of B lymphocytes, either naturally (e.g., in cold haemagglutinin) or produced synthetically by fusing an immortal cell (mouse myeloma) to a cell producing an antibody against a desired antigen. (thefreedictionary.com)

The cryoprecipitate was isolated and found to be negative for HCV nucleic acid and antibodies. (who.int)
All antibodies, except natural antibodies (antibodies to different blood types), are made by B cells stimulated by a foreign antigen, typically a foreign protein, polysaccharide, or nucleic acid. (thefreedictionary.com)

Anatomy11

Organisms2

Diseases30

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes16

Disciplines and Occupations1

Information Science3

Health Care8

Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis. (1/823)

Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. (2/823)

Prominence of cell-mediated immunity effectors in "pauci-immune" glomerulonephritis. (3/823)

Microscopic polyangiitis: clinical and laboratory findings in eighty-five patients. (4/823)

Thrombotic thrombocytopenic purpura and autoimmunity: a tale of shadows and suspects. (5/823)

Wegener's granulomatosis associated with renal cell carcinoma. (6/823)

Expression of major histocompatibility class II antigens on polymorphonuclear neutrophils in patients with Wegener's granulomatosis. (7/823)

Definition of ocular antigens in ciliary body and retinal ganglion cells by the marker antibody pANCA. (8/823)

Antibodies, Antineutrophil Cytoplasmic

Vasculitis

Wegener Granulomatosis

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Myeloblastin

Antibodies

Antibody Specificity

Peroxidase

Antibodies, Viral

Antibodies, Monoclonal

Churg-Strauss Syndrome

Antibodies, Bacterial

Microscopic Polyangiitis

Propylthiouracil

Fluorescent Antibody Technique, Indirect

Vasculitis, Leukocytoclastic, Cutaneous

Glomerulonephritis

Autoantibodies

Antithyroid Agents

Antibody Formation

Antibodies, Neutralizing

Fluorescent Antibody Technique

Neutrophils

Serine Endopeptidases

Polyarteritis Nodosa

Antibodies, Antinuclear

Enzyme-Linked Immunosorbent Assay

Antibody Affinity

Antibodies, Anti-Idiotypic

Antibodies, Fungal

Immunoglobulin G

Binding Sites, Antibody

Colitis, Ulcerative

HIV Antibodies

Endocarditis, Subacute Bacterial

Immunosuppressive Agents

Epitopes

Antibodies, Neoplasm

Antibodies, Protozoan

Purpura, Schoenlein-Henoch

Autoantigens

Autoimmune Diseases

Antibodies, Monoclonal, Murine-Derived

Immune Sera

Lysosomal-Associated Membrane Protein 2

Neutrophil Activation

Biological Markers

Cross Reactions

Graves Disease

Prednisolone

Methimazole

Cyclophosphamide

Fixatives

Nose Diseases

Respiratory Burst

Cathepsin G

Eosinophilia-Myalgia Syndrome

Immunoglobulin M

Focal Infection

Lung Diseases

Plasma Exchange

Neutralization Tests

Scleritis

Sensitivity and Specificity

Hemoptysis

Proctocolectomy, Restorative

Methylprednisolone

Recurrence

Antigen-Antibody Reactions

Pancreatic Elastase

Antibodies, Bispecific

Molecular Sequence Data

Drug Contamination

Single-Chain Antibodies

Mice, Inbred BALB C

Antibodies, Blocking

Amino Acid Sequence

Biopsy

Cholangitis, Sclerosing

Antigen-Antibody Complex