Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Three or more consecutive spontaneous abortions.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Formation and development of a thrombus or blood clot in the blood vessel.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.
Endogenous substances, usually proteins, that are involved in the blood coagulation process.
A disorder of HEMOSTASIS in which there is a tendency for the occurrence of THROMBOSIS.
The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties.
A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
Laboratory tests for evaluating the individual's clotting mechanism.
Sites on an antigen that interact with specific antibodies.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.
Central nervous system vasculitis that is associated with SYSTEMIC LUPUS ERYTHEMATOSUS. Clinical manifestations may include DEMENTIA; SEIZURES; CRANIAL NERVE DISEASES; HEMIPARESIS; BLINDNESS; DYSPHASIA; and other neurological disorders.
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A subnormal level of BLOOD PLATELETS.
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
Antibodies reactive with HIV ANTIGENS.
A hemostatic disorder characterized by a poor anticoagulant response to activated protein C (APC). The activated form of Factor V (Factor Va) is more slowly degraded by activated protein C. Factor V Leiden mutation (R506Q) is the most common cause of APC resistance.
An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
The co-occurrence of pregnancy and a blood disease (HEMATOLOGIC DISEASES) which involves BLOOD CELLS or COAGULATION FACTORS. The hematologic disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.
Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.
Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.
The formation or presence of a blood clot (THROMBUS) within a vein.
Agents that prevent clotting.
A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Immunoglobulins produced in a response to FUNGAL ANTIGENS.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER).
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Techniques for removal by adsorption and subsequent elution of a specific antibody or antigen using an immunosorbent containing the homologous antigen or antibody.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)
Heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.
Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
Diminished or absent ability of a female to achieve conception.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).

Antibodies against phospholipids and oxidized LDL in alcoholic patients. (1/381)

Antiphospholipid antibodies (APA) are a generic term describing antibodies that recognize various phospholipids. Hepatocyte damage is a cardinal event in the course of alcoholic liver injury and autoantibodies against phospholipids could play an important role in this process. APA in alcoholic patients seem to reflect membrane lesions, impairment of immunological reactivity, liver disease progression and they correlate significantly with disease severity. LDL oxidation is supposed to be one of the most important pathogenic mechanisms of atherosclerosis and antibodies against oxidized low-density lipoprotein (oxLDL) are some kind of an epiphenomenon of this process. The scope of our study was to determine some autoantibodies (IgG-oxLDL and antiphospholipid antibodies) and their possible changes in alcoholic patients. We studied IgG-oxLDL and four APA - anticardiolipin antibodies (ACA), antiphosphatidylserine antibodies (APSA) antiphosphatidylethanolamine antibodies (APE) and antiphosphatidylcholine antibodies (APCA) in 35 alcoholic patients with mildly affected liver function at the beginning of the abuse treatment. The control group consisted of 60 healthy blood donors. In the studied group, we obtained positive results concerning total ACA in 17.1 % of alcoholic patients (8.3 % in the control group), 11.4 % IgG-ACA (6.7 %), 8.6 % IgM-ACA (3.3 %), 14.3 % total APE (6.7 %), 14.3 % total APCA (8.3 %) and 20 % total APSA (8.3 % in the control group). The IgG-oxLDL (406.4+/-52.5 vs 499.9+/-52.5 mU/ml) was not affected in alcoholic patients. We conclude that the autoantibodies against oxLDL are present in sera of alcoholics and healthy blood donors. Based on our results which revealed a wide range of IgG-oxLDL titres in the healthy population, this parameter does not appear to be very promising for the evaluation of the risk of atherosclerosis. Alcoholics with only mild affection of liver functions did not exhibit a significantly higher prevalence of all studied antiphospholipid antibodies (ACA, APSA, APE, APCA) which could lead to membrane lesions in these patients.  (+info)

Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (2/381)

BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection.  (+info)

Anti-phospholipid antibodies and CD5+ B cells in HIV infection. (3/381)

This cross-sectional study evaluates the correlation between anti-phospholipid antibodies and CD5+ B cells in 110 patients infected with HIV-1. There were 89.1% of the patients who had IgG antibodies against cardiolipin and phosphatidylserine. The prevalence of IgM and IgA antibodies was < 22%. AIDS was associated with lower frequencies of IgM antibodies against cardiolipin (P = 0.05) and IgG-antibodies against cardiolipin and phosphatidylserine (P = 0.011). Drug users had higher IgM antibodies against phospholipids than patients from other risk groups (P = 0.02). A history of thromboembolic events was not accompanied by higher levels of anti-phospholipid antibodies (P > 0.2). No correlation between anti-phospholipid antibodies and CD5+ B cells was detected. Percentage part of CD5+ B lymphocytes was elevated in all patients and absolute CD4+ T lymphocyte counts and HIV p24 antigen were inversely correlated. In advanced disease a significant reduction of anti-phospholipid antibodies was contrasted with persistent elevation of CD5+ B lymphocytes. These observations may reflect immunological dysfunction involving apoptosis and endothelial damage rather than polyclonal B cell hyperstimulation. A possible explanation would be that in HIV infection an increased rate of spontaneous apoptosis in peripheral blood lymphocytes is accompanied by functional and structural changes of mitochondria. Therefore, structurally altered mitochondrial phospholipids could serve as antigen to induce specific humoral immune responses.  (+info)

Antibodies to adult human endothelial cells cross-react with oxidized low-density lipoprotein and beta 2-glycoprotein I (beta 2-GPI) in systemic lupus erythematosus. (4/381)

Cardiovascular manifestations are common in systemic lupus erythematosus (SLE). Oxidized low-density lipoprotein (oxLDL) is implicated in cardiovascular disease, especially atherosclerosis, and cross-reacts with antibodies to cardiolipin (aCL). beta 2-GPI is a plasma protein participating in the coagulating cascade, and is also cofactor for aCL, and some aCL have been shown to be directed against beta 2-GPI and/or complexes between beta 2-GPI and phospholipids. Lysophosphatidylcholine (LPC) is a phospholipid present both in oxLDL and in damaged endothelium, and we recently showed that LPC is involved in the antigenicity of oxLDL. Antibodies to endothelial cells (aEC) correlate with diseases activity in SLE and vasculitis, and we recently showed that aEC are enhanced in cardiovascular disease such as borderline hypertension and early atherosclerosis. aEC were determined using EC from adult V. Saphena Magna. Antibody levels were determined by ELISA. aEC of IgG type were enhanced in 184 patients with SLE compared with 85 healthy controls. There was a close correlation between aoxLDL, aCL, aLPC, a beta 2-GPI and aEC. Binding of sera to EC was competitively inhibited by beta 2-GPI, LPC and oxLDL. Taken together, the data indicate that EC share antigenic epitopes with beta 2-GPI and with oxLDL, especially LPC. Phospholipids in EC membranes may thus be antigenic epitopes. beta 2-GPI may bind to these phospholipids, and become an autoantigen. LPC is formed by oxidation of phospholipids and/or proinflammatory factors leading to activation of phospholipase A2, and the findings indicate the potential role of both lipid oxidation and phospholipase A2 in SLE.  (+info)

Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. (5/381)

Anti-cardiolipin autoantibodies (aCL) induce thrombosis and recurrent fetal death. These antibodies require a 'cofactor', identified as beta 2-glycoprotein I (beta 2-GPI), to bind phospholipids. We show here that aCL can bind beta 2-GPI in the absence of phospholipid. Binding of aCL to beta 2-GPI is dependent upon the beta 2-GPI being immobilized on an appropriate surface including cardiolipin, irradiated polystyrene and nitrocellulose membrane. This effect cannot be explained by increased antigen density of beta 2-GPI immobilized on these surfaces. Rather, conformational changes that occur following the interaction of beta 2-GPI with phospholipid render this protein antigenic to aCL. Liquid-phase beta 2-GPI was not antigenic for aCL. Thus, aCL cannot bind circulating beta 2-GPI. These findings may explain why patients with aCL can remain healthy for many years but then undergo episodes of thrombosis or fetal loss without changes in their circulating aCL profile, as the triggering event for these pathologies can be predicted to be one that renders beta 2-GPI antigenic for aCL.  (+info)

A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus. (6/381)

OBJECTIVE: To prospectively analyze the association between changes in cognitive function and circulating anticardiolipin antibodies (aCL) over a period of 5 years in patients with systemic lupus erythematosus (SLE). METHODS: Cognitive function was assessed in 51 unselected female SLE patients at baseline and after a mean followup of 64.5 months (range 52-71 months), using standardized tests of cognitive function, i.e., the Wechsler Adult Intelligence Scale-Revised, the Wechsler Memory Scale-Revised, and the California Verbal Learning Test. Circulating IgG, IgA, and IgM aCL and anti-double-stranded DNA (anti-dsDNA) antibody levels were determined by enzyme-linked immunosorbent assay on 4-7 occasions over the same time period. Persistent antibody reactivity was defined as levels more than 2 standard deviations (moderately positive) and more than 5 standard deviations (highly positive) above the mean for normal controls over the duration of the study. Changes in overall cognitive performance and in raw scores on individual cognitive tests were compared in patients who were persistently positive or negative for aCL. RESULTS: At baseline 11 patients (22%) were cognitively impaired, compared with 7 (14%) at followup. Between 16% and 37% of patients had persistently elevated aCL levels of different isotypes. There was no significant difference in the prevalence of overall cognitive impairment in patients who were persistently positive for aCL compared with those who were not. In contrast, over the period of study, patients who had persistent IgG aCL positivity had a reduction in psychomotor speed, and patients who had persistent IgA aCL positivity had a reduction in conceptual reasoning and executive ability. Similar associations with anti-dsDNA antibodies were not found. CONCLUSION: These results suggest that IgG and IgA aCL may be responsible for long-term subtle deterioration in cognitive function in patients with SLE.  (+info)

A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus. (7/381)

OBJECTIVE: To determine the relationship between persistently raised anticardiolipin antibody (aCL) levels and neuropsychological performance in patients with systemic lupus erythematosus (SLE). METHODS: Forty-five patients with SLE underwent a detailed neuropsychological assessment on 2 occasions 12-18 months apart. Serum samples stored since the time of previous assessments as well as samples obtained 6 months to 2 years before the first neuropsychological assessment were tested for IgG aCL levels. Patients were divided into 4 groups according to the number of times their aCL levels were elevated (never, once, twice, 3 times). A wide-ranging battery of new neuropsychological tests was utilized, and the results were compared with double-stranded DNA (dsDNA) antibody levels, C3 levels, and results of magnetic resonance imaging (MRI). RESULTS: Analysis of variance revealed that the group with persistently elevated aCL levels performed less well than the other groups. At the first neuropsychological assessment, poorer performance by this group was noted for letter cancellation (P = 0.02), trail making task B (P = 0.04), and digit span (P = 0.03). At the second assessment, letter cancellation (P = 0.01), trail making task A (P = 0.03), trail making task B (P = 0.01), word fluency (P = 0.01), and reaction time (P = 0.05) were impaired. In contrast, no significant differences in neuropsychological test results were identified with respect to DNA antibody or C3 levels. MRI abnormalities were associated with both persistent elevation of aCL levels and low C3 levels. CONCLUSION: Levels of IgG aCL that were persistently elevated over a 2-3-year period (as opposed to never or occasionally elevated) were associated with significantly poorer performance in cognitive function by patients with SLE. Tasks requiring speed of attention and concentration appear to be particularly affected.  (+info)

A possible role for activated protein C resistance in patients with first and second trimester pregnancy failure. (8/381)

Thrombophilia was recently suggested as a possible factor in recurrent pregnancy losses. We studied prospectively 125 patients (mean age 31.4 +/- 5.6 years) with one or more first or second trimester pregnancy losses for the prevalence of activated protein C resistance (APCR). Proteins C and S antigens, antithrombin III, anticardiolipin, and lupus anti-coagulant were also evaluated. Patients with uterine malformations, hormonal abnormalities, chromosomal translocations and infectious causes were excluded. A control group of 125 women with no past fetal loss were matched with the study group. Whenever the APC-sensitivity ratio (APC-SR) was +info)

Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles were studied for their effects on lymphocytes and neutrophils. At a concentration of 160 micrograms/ml they markedly suppressed the [3H]thymidine incorporation of mononuclear cells stimulated by phytohaemagglutinin (4.9 (SEM 1.9%) of the control) and pokeweed mitogen (26.7 (10.5%) of the control). In addition, anticardiolipin antibodies changed the cell cycle of phytohaemagglutinin stimulated lymphocytes such that the S and G2+M phases were significantly diminished (G0/G1 = 64.62%, S = 20.59%, G2+M = 14.78% in the presence of normal human IgG v G0/G1 = 86.07%, S = 10.32%, G2+M = 3.59% in the presence of anticardiolipin antibodies). The suppression of lymphocyte proliferation by anticardiolipin antibodies was shown not to be caused by an alteration of T cell subpopulations. However, the interleukin 2 receptors on the cell surface and the soluble interleukin 2 receptors in ...
TY - JOUR. T1 - Accuracy of Anticardiolipin Antibodies in Identifying a History of Thrombosis Among Patients With Systemic Lupus Erythematosus. AU - Escalante, Agustín. AU - L. Brey, Robin. AU - D.Mitchell Jr., Braxton. AU - Dreiner, Ute. PY - 1995/6. Y1 - 1995/6. N2 - objective: To measure the accuracy of anticardiolipin antibodies (aCL) in identifying a history of thrombosis among patients with systemic lupus erythematosus (SLE) or the primary antiphospholipid syndrome (PAPS). patients and methods: Patients with SLE or PAPS who attended our rheumatology clinic between April 1992 and March 1994 were included in a retrospective analysis of the relationship between thrombotic events and aCL. All aCL measurements were performed in the same laboratory by enzyme-linked immunosorbent assay, blinded as to the presence or absence of thrombosis. The diagnostic accuracy of IgG, IgM, and IgA aCL was quantified by means of the receiver operating characteristic area under the curve (ROC AUC) for each ...
TY - JOUR. T1 - Elevated anticardiolipin antibodies in a patient with vibration-white-finger, valvular heart disease and psoriatic arthritis. AU - McHugh, N J. AU - Elvins, D M. AU - Ring, E F. PY - 1993/3. Y1 - 1993/3. N2 - We describe a case of irreversible severe vibration-white-finger (VWF) occurring in a male who used a compression-hammer daily at work for a 20-year period. Infra-red thermography following either a cold provocation or a vibratory stress was a sensitive objective method of documenting the condition. Persistent elevation of IgG anticardiolipin antibodies (aCL) was found in his serum and may be a marker of endothelial damage associated with either VWF or the patients coincidental valvular heart disease.. AB - We describe a case of irreversible severe vibration-white-finger (VWF) occurring in a male who used a compression-hammer daily at work for a 20-year period. Infra-red thermography following either a cold provocation or a vibratory stress was a sensitive objective method ...
To the Editor: Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with infectious mononucleosis and postulated the existence of cross-reactions between infectious (viral) antigens and cardiolipin. We report here our experience concerning immunologic and biochemical similarities between Pneumocystis carinii organisms and cardiolipin. We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among those patients who had active P. carinii pneumonia (2). To test the cross-reactive hypothesis, we did several experiments.. In the first set of experiments, rabbits were immunized with an antigen from P. carinii in Freunds adjuvant prepared according ...
Hepatitis C, a worldwide viral infection, is an important health problem in Brazil. The virus causes chronic infection, provoking B lymphocyte dysfunction, as represented by cryoglobulinemia, non-organ-specific autoantibody production, and non-Hodgkins lymphoma. The aim of this research was to screen for the presence of antiphospholipid autoantibodies in 109 Brazilian hepatitis C virus carriers without clinical history of antiphospholipid syndrome. Forty healthy individuals were used as the control group. IgA, IgG, and IgM antibodies against cardiolipin and β2-glycoprotein I were measured with an enzyme-linked immunosorbent assay, using a cut-off point of either 20 UPL or 20 SBU. While 24 (22.0%) hepatitis C carriers had moderate titers of IgM anticardiolipin antibodies (median, 22.5 MPL; 95%CI: 21.5-25.4 MPL), only three carriers (,3%) had IgG anticardiolipin antibodies (median, 23 GPL; 95%CI: 20.5-25.5 GPL). Furthermore, IgA anticardiolipin antibodies were not detected in these individuals. ...
Background: Graves disease is an autoimmune disease, characterized by the presence of antibodies directed to TSH receptor or nearby regions as well as antibodies to double strands DNA (dsDNA) anticardiolipin and nuclear antibodies. This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves disease. Patients and methods: Anticardiolipin and rheumatoid factor were measured in sera of 84 patients (29 male, 55 female) with evidence of Graves disease and 41 healthy individuals (15 male, 26 female) with negative history of hyperthyroidism and other autoimmune diseases. Results: Mean level of anti cardiolipin antibody (ACLA) in patients and control groups were 0.192±0.11 and 0.087±0.200 optical density (OD) respectively. The level of IgM-Rhematoid factor (IgM-RF) of patients and healthy control groups was the same, whereas the mean IgA-RF levels in patients was significantly lower than control group. Conclusion: Anticardiolipin level in different
Our data suggest that subsequent thrombo-occlusive events and death after focal cerebral ischemia may occur sooner and more frequently in patients found to have IgG aCL immunoreactivity ,40 GPL units at the time of their index focal cerebral ischemic event when compared with patients who harbor 10 to 40 GPL at the time of their index event. Therefore GPL ,40 may be an important prognostic marker for subsequent thrombo-occlusive events in patients with index focal cerebral ischemia. Patients with ,40 GPL also appear to have more features of the antiphospholipid syndrome: younger age at onset and more recurrent strokes at the time of diagnosis.21 Furthermore, being in the GPL ,40 group appears to confer a sixfold-increased risk of developing subsequent TIAs only compared with being in the GPL ≤40 group. TIAs do not generally have as equally bad an outcome as ischemic stroke, although many hemispheric TIAs are minor infarcts by persistent subtle signs or neuroimaging abnormalities, and cognitive ...
Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly bind to beta 2-glycoprotein I (beta 2-GPI), which is adsorbed to an oxidized polystyrene surface. Oxygen atoms were introduced on a polystyrene surface by irradiation with electron or gamma-ray radiation. X-ray photoelectron spectroscopy revealed the irradiated surfaces were oxidized to generate C-O and C = O moieties. aCL derived from either APS patients or (NZW x BXSB)F1 mice bound to beta 2-GPI coated on the irradiated plates, depending on the radiation dose. Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL)-coated latex beads mixed together with beta 2-GPI but were unaffected by addition of excess beta 2-GPI, CL micelles, or CL-coated latex beads alone. There was a high correlation between binding values of aCL in sera from 40 APS patients obtained by the anti-beta 2-GPI enzyme-linked ...
Anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) have been detected in patients with hepatitis C virus (HCV) infection and have been associated in autoimmune diseases (i.e. systemic lupus erythematosus) with an increased risk of thromboembolic events. Because of the high prevalence of H …
Dont be scared! There a a lot of us walking around with these antiphospholipid antibodies that never affect our health. It isnt known why in maybe a third of us that has them they suddenly play up. They can even appear in pregnancy and disappear afterwards. Either the anticardiolipin tests or the lupus anticoagulant can be positive at any time or negative. Thats why both tests are usually done together. Levels can vary too just as the body goes about its normal business so both tests need to be done at an interval of at least 6-8 weeks to see if they are constantly present and at what levels. They are not always due to autoimmune disease either. Leverls can be abnormal in infectious or other diseases so often certain tests are also done which indicate if they are autoimmune in ...
Although raised levels of aPLs were first reported in patients with autoimmune diseases, their presence is now known to be more widespread.1 Elevated serum levels of all three aCL isotypes, IgG, IgM, and IgA, have been reported in human infections caused by bacteria, viruses, spirochetes, and parasites; a higher prevalence of the IgG aCL isotype has been found in syphilis, HIV, tuberculosis, Q fever, Lyme disease, and cytomegalovirus infections.15 The mechanism of the aCL response to chronic infection such as that caused by HIV-1 and HCV is unclear. Infection induced aCLs have been shown to differ from autoimmune aCLs. The former tend to be transient, of low titre, and more often of the IgM isotype; in contrast, autoimmune aCLs often have highly sustained rather than transient titres, and are more often of the IgG isotype.15 21 Prieto et al 13 reported the presence of IgG aCLs in 22% of HCV infected patients. This contrasts with a previous report by Gotoh and Matsuda,22 who found significantly ...
Researchers assessed the effect of belimumab vs placebo on antiphospholipid antibodies from 2 large randomized controlled trials, BLISS-76 and BLISS-52.
Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.
My GP kindly agreed to Level 1 tests which I had arranged in February to ensure that I had the results before seeing Dr Gorgy. The tests were for lupus anticoagulant, natural killer cells, rheumatoid arthritis, thyroid function, anticardiolipin antibodies, FSH, LH and oestradoil. The last 3 tests are not very useful because they were done on day 13 of my cycle because my GP insisted that it wasnt necessary to do this on days 2 to 4 of cycle as I had requested. Ive been told on the phone that all the tests were normal but I requested copies of the test results which I received yesterday. Looking at the results, if I read it correctly, I think they forgot to send blood specimen for the lupus anticoagulant. WTF?!? Also, it showed a bunch of tests that didnt look anything like the Level 1 immune tests I did previously in 2008 or the named tests. Maybe Dr Gorgy will make some sense of it all ...
혈액투석 환자에서 혈전형성에 의한 동정맥루 폐쇄 (vascualr access occlusion)는 가장 흔한 합병증 중의 하나로 혈관 수술 기술의 발전, 동맥경화증의 치료 및 항 혈소판 제제 사용을 포함한 약물적 치료에도 불구하고 혈액투석 환자 중 입원일수의 5-50% 정도를 차지하는 것으로 되어 있다. Anticardiolipin Antibody(ACA) 와 lupus anticoagulant(LA)는 항 인지질 항체들로 혈관 폐쇄 및 반복적인 유산의 중요한 위험인자로 알려져 있으나 혈액투석 치료를 받는 환자에서의 정확한 양성율 및 동정맥루 폐쇄와의 상관관계에 관해서는 아직 많은 이견이 있는 상태이다. 이에 저자는 이화여자대학교 부속병원에서 유지 혈액투석 중인 환자 50명, 총 68예의 동정맥루 (52 AV fistula, 16 AV grafts)를 대상으로 항 cardiolipin 항체와 루프스 항응고인자를 측정하고 병력 및 임상 기록 검토를 통해 이러한 ...
8 mmol/L 124 μmol/L pending What further two investigations would you order? (a) Erythrocyte sedimentation rate (b) SLE-serology (ANA and anti-DNA) (c) Transthoracic echocardiography (d) Anticardiolipin antibody (e) Chest x-ray (f) C-reactive protein (g) Further blood cultures (h) Electrocardiogram (i) Rheumatoid factor (j) Anti Scl-70 3 Other than appropriate blood pressure control, give two treatments you would consider for your first diagnosis: (a) Delivery of fetus (b) Warfarin (c) Heparin (d) Azathioprine (e) Cyclophosphamide (f) Magnesium (g) Methotrexate (h) Non-steroidal anti-inflammatory (i) Prednisolone (j) Vasodilators Questions: Exam A 2 28 Examination A Question 42 Questions: Exam A 1 What is the abnormality? A) Aspergillosis precipitins (b) Skin tests for aspergilla sensitivity (c) Heaf test (d) Bronchoscopy (e) Sputum smear microscopy and culture (f) Serology for anti-BM antibodies (g) ANCA (h) Open lung biopsy (i) Rheumatoid factor and lupus serology (j) HIV test Questions: ...
I am feeling a roller coaster of feelings, right now: Relief, irritation, frustration, love, joy, regret, blah…. Last week my cardiologist drew 9 vials of blood to see if we can get to the bottom of my blood clots prior to repairing my shunt. There have been some things consistently out of whack, so he wanted sort that out before he does my procedure on November 1st. He called me with the test results yesterday morning. Two things concerned him. One is the anticardiolipin antibody IGM, which has been in the moderate range all three times. The other is Factor V Lieden. Both things cause blood clots. The IGM also attacks the blood vessels, cell walls and heart valves, which could be causing my hemolytic anemia, hemolysis and the three funky heart valves… So hes now sending me to a hematologist to get me on the right medications before my procedure. The major concern is that r-l shunt is allowing blue blood, clots and bacteria to skip the filtration of the lungs and go to the brain and ...
August 15, 2012: We consulted with a fertility doctor who specializes in artificial insemination (also called IUI). He ordered a lot of blood work and procedures for me to finish out the diagnosis for my side of things. So far, I know that my estradiol and FSH are good. I also know that I am heterozygous for the MTHFR gene, which is involved with blood clots. That gene puts me at a higher risk for developing blood clots, but it turns out that another of my factors is wonky (will update when I know the name Update: It is the anticardiolipin antibody IGM that is elevated.) is a more significant risk. I also had an x-ray today (8/22) called an HSG. They injected contrast dye into my business and x-rayed to make sure that all my tubes and uterus are open and inviting. Good news--they are. We are still waiting on some of the blood work to come back (including my CF gene testing). Current medications: Prenatal with DHA, Vitamin D, Calcium, MTHFR capsule. Also, he explained why we would need to ...
AccessGUDID - ANTI-CARDIOLIPIN IgA (04260157080133)- Anti-Cardiolipin Screen is an ELISA test system for the quantitative measurement of IgA class autoantibodies against cardiolipin in human serum or plasma. This product is intended for professional in vitro diagnostic use only.
A cautious yes from your MFM is good news! My MFM said that if she was just looking at my risk of PE based on my current kidney disease, she would say it was about a 1/3 chance of getting it. However due to my previous history of early severe PE, she puts the risk at about 2/3 but cant predict if it would be early again or later. Im kind of sad about those odds, but I understood that was probably the situation even before I had this visit. She did say that in my favor, the blood pressure and kidney disease have been well-controlled and my hypothyroidism is being treated (last time I didnt know about any of these issues until after I was pregnant) which may result in a better outcome. So like your MFM, she gave a cautious yes. I had the same labs drawn as you did and am waiting for the results which should be in on Wednesday. I already had the anticardiolipin labs done a few months ago and those were negative. I also did a repeat 24 hour urine for creatinine clearance and protein and am ...
Meet Jane. Most days she is like any other 37-year-old professional woman. Busy with her career and 8-year-old, she is always running off to some important meeting or soccer game. Some days, however, she is a migraine sufferer. She is among the 17% of women who suffer from migraines each year 1. She suffers the…
OBJECTIVE To determine the prevalence of cardiac valvular involvement in patients with the primary antiphospholipid syndrome. DESIGN Cross-sectional study with evaluation of case patients and control patients by Doppler echocardiography. The mean follow-up for case patients was 22 months. SETTING University-based tertiary medical center. PATIENTS Twenty-eight consecutive patients who were diagnosed with the primary antiphospholipid syndrome during a 10-year period; 28 age- and sex-matched healthy controls. MEASUREMENTS AND MAIN RESULTS Ten patients (36%; 95% Cl, 19% to 56%) with the primary antiphospholipid syndrome had cardiac valvular involvement: Four patients had mitral valve involvement; four patients, aortic valve involvement; and two patients, both mitral and aortic valvular involvement; no patients had tricuspid or pulmonary valve disease. Eight of 10 patients had a regurgitant murmur. None of the control patients had valvular disease. The mean mitral valve thickness in patients with
Abstract: The confirmation of diagnosis of the Antiphospholipid Syndrome (APS) relies on laboratory tests. Current classification criteria for definite APS mandate the use of three standardized laboratory assays to detect antiphospholipid antibodies (aPL) [viz: anticardiolipin (aCL) IgG and IgM, anti-β(2) glycoprotein I (anti-β(2) GPI) antibodies IgG and IgM and/or a lupus anticoagulant (LAC)], when at least one of the two major clinical manifestations (thrombosis or pregnancy losses) are present. Although International Consensus Guidelines for the determination of LAC have been published and revised, the existence of standardized tests for detection of aCL and anti-β(2) GPI has remained elusive. In spite of the publication of several proposals, consensus documents and expert opinions, significant inter-assay and inter-laboratory variation in the results of both aCL and anti-β(2) GPI testing still exists, which affects the consistency of the diagnosis of APS. At the 13(th) International ...
Six cases of congenital thrombophilia (15%) were found: 1 PC deficiency (patient 25), 1 PS deficiency (patient 34), and 4 heterozygous factor V Leiden (patients 21, 22, 28, and 30). Three patients had increased aCL antibodies, 1 with systemic lupus (patient 21) and 2 with a primary aPL syndrome (patients 8 and 22); 2 of these had also factor V Leiden mutation. There was no antithrombin or plasminogen deficiency. Cases with thrombophilia and/or aCL antibodies are briefly summarized. Treatment and outcome are not detailed because all patients received heparin followed by oral anticoagulants and made an uneventful recovery.. Patient 25 was 34 years old in 1986 when she complained of headache, seizures, and left-sided sensory symptoms in a context of uveomeningitis. No other signs of Behçets disease11 or sarcoidosis were present. Angiography and MRI showed right LS thrombosis. The patient has been well since then. While receiving oral anticoagulants, PC activity was 24%, antigen was 33%, and ...
Pulmonary embolism is the most common pulmonary manifestation of primary antiphospholipid syndrome (PAPS). However, PAPS may manifest in the respiratory system also due to non-thrombotic processes. In the following paper we present a case of PAPS-related diffuse alveolar hemorrhage (DAH). Because of sparse literature and a lack of randomized controlled trials, there are currently no recommendations regarding the optimal choice of steroid-sparing agent in treating PAPS-related DAH. In our patient, treatment with cyclophosphamide or mycophenolate mofetil along with low dose prednisone was ineffective, partially because of infectious complications, whereas addition of monthly intravenous immunoglobulin to mycophenolate mofetil and prednisone, appears to control the disease. ...
We evaluated inter-assay variation in anticardiolipin antibody status, comparing three centres, and using different assays among 36 women with recurrent miscarriage and 26 controls. There was no more agreement between the laboratories than would be predicted on the basis of chance for IgM and only fair agreement among the laboratories for IgG. None of the tests were significantly more likely to be positive in the cases compared with the controls ...
Recurrent pregnancy loss (RPL) can be defined as more than two to three consecutive miscarriages before 24 weeks gestation. A literature review was done to provide an evidence-based approach to RPL, identifying the risk factors and causes and also looking at the various special investigations that form part of the work-up and trying to assess which have been proven to be effective or of negative impact, and which of the management options lead to a better outcome. We concluded that the following special investigations should be part of the work-up for all patients with RPL: (i) genetic counselling and karyotyping of the abortus; (ii) anticardiolipin antibodies and lupus anticoagulant testing must be done on two occasions, 6 - 8 weeks apart; (iii) all patients qualify for a pelvic ultrasound scan and hysteroscopy; (iv) syphilis testing must be done routinely; and (v) testing of thyroid function and glucose monitoring/glycosylated haemoglobin (HbA1c) measurement must be done in all patients with ...
Outcome of primary antiphospholipid syndrome in childhood. Gattorno, M.; Falcini, F.; Ravelli, A.; Zulian, F.; Buoncompagni, A.; Martini, G.; Resti, M.; Picco, P.; Martini, A. // Lupus;2003, Vol. 12 Issue 6, p449 The objective of this paper is to investigate the long-term outcome of primary antiphospholipid syndrome (APS) in the paediatric age. The features of unselected patients with primary APS who had disease onset before the age of 16 years were retrospectively analysed in three Italian referral... ...
HealthDay Reporter. (HealthDay News) -- Maureen Murphy believes she has much to lose if Republicans in Congress pass a bill to repeal and replace the Affordable Care Act, also known as Obamacare.. One of millions of Americans with a pre-existing condition, Murphy was a healthy nonsmoker with normal blood pressure when her medical saga began.. What one hospital wrongly diagnosed as Bells palsy turned out to be antiphospholipid antibody syndrome with anticardiolipin antibodies. In short, her own body was attacking normal blood proteins and forming multiple blood clots. An MRI revealed that she had suffered a series of small strokes.. Murphy, a television and video production specialist, had tried to buy coverage ahead of her diagnosis in October 2010. But she got stung by a proposed rate hike because of a pre-existing condition. Turns out she had been tagged with depression because she attended bereavement counseling after the death of her parents.. When she later reapplied for coverage, the ...
HealthDay Reporter. (HealthDay News) -- Maureen Murphy believes she has much to lose if Republicans in Congress pass a bill to repeal and replace the Affordable Care Act, also known as Obamacare.. One of millions of Americans with a pre-existing condition, Murphy was a healthy nonsmoker with normal blood pressure when her medical saga began.. What one hospital wrongly diagnosed as Bells palsy turned out to be antiphospholipid antibody syndrome with anticardiolipin antibodies. In short, her own body was attacking normal blood proteins and forming multiple blood clots. An MRI revealed that she had suffered a series of small strokes.. Murphy, a television and video production specialist, had tried to buy coverage ahead of her diagnosis in October 2010. But she got stung by a proposed rate hike because of a pre-existing condition. Turns out she had been tagged with depression because she attended bereavement counseling after the death of her parents.. When she later reapplied for coverage, the ...
Results. In patients with suspected systemic rheumatic diseases, 72% satisfied American College of Rheumatology classification criteria: 40 (36%) had rheumatoid arthritis (RA), 16 (15%) systemic lupus erythematosus, 8 (7%) scleroderma, 8 (7%) osteoarthritis, 4 (4%) fibromyalgia, 2 (2%) seronegative spondyloarthropathy, 1 Sjögrens syndrome, and 1 sarcoidosis. Compared to controls, RA patient sera were more likely to contain anti-CCP (55% vs 2%; p , 0.001) or RF IgM antibodies (57% vs 10%; p , 0.001); however, the difference was greater for anti-CCP. Anti-CCP positivity conferred higher disease activity scores (DAS28 5.6 vs 4.45; p = 0.021) while RF positivity did not (DAS28 5.36 vs 4.64; p = 0.15). Anticardiolipin antibodies (25% of rheumatic disease patients vs 10% of controls; p = 0.0022) and ANA (63% vs 21%; p , 0.0001) were more common in rheumatic disease patients. ...
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Dear Thyroid experts:. I had a patient who was admitted to hospital with confusion. she is 39 yo with known Hashimotos found last month to present with tonic-clonic seizure. Not doing well for one month and problems with word finding. ct at outlying hospital reported as cerebral edema. EEG revealed bifrontal rhythms and polymorphic slowing. Had a ventriculostomy placed due to CSF pressure of 20. Pt discharged and then represented with confusion ...Further investigations showed questionable cerebritis around ventriculostomy site on MRI . Other w/u at outside hospital neg HSV/PCR, transthoracic echo neg, CT angiogram positive for PE with positive anticardiolipin antibody. Pt then anticoagulated prior to transfer to our institution--- Found to have elevated microsomal ab 1:6400, and anti TPO 2517. Patient was seen by rheumatologist with negative workup at our institution (neg for ANA, anti DNA , anti RNA, SSA, SSB, SCL70 and chromatin antibodies negative, c3 208 ). Underwent plasmapheresis and ...
Synonyms for Acla in Free Thesaurus. Antonyms for Acla. 21 words related to antibody: active site, protein, autoantibody, precipitin, ABO antibodies, Rh antibody, antitoxin, agglutinin, Forssman antibody.... What are synonyms for Acla?
PMID 19740902] Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population [PMID 19644876] Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome [PMID 19796918 ...
Recurrent Abortion, Causes and Management Dr. Mazen El-Zibdeh MD DRCPI, MRCOG, FRCOG Senior Consultant Ob. Gyn. Islamic Hospital Amman-Jordan
Washington, D.C. - Following the announcement of new steps and updated CDC guidelines to ramp up testing and help schools reopen, ACLA President Julie Khani released the following statement:. Americans are eager to return to work and school, and all accurate and reliable tests have a role in getting us there. We applaud the Biden Administration for taking additional steps to ensure all communities have access to the full range of testing options available.. Clinical laboratories have introduced a range of new tests and techniques to meet widespread patient need, including the development of the at-home specimen collection kits, the expanded use of specimen pooling and multiplex testing, and the launch of serologic testing and novel RNA extraction methods. We remain focused on expanding access to accurate and reliable testing for the patients who are counting on us and stand ready to expand our support in local communities.. ###. The American Clinical Laboratory Association (ACLA) is the ...
2WW = 2-Week Wait 47XXY = Klinefelters Syndrome ACA = Anti-cardiolipin Antibodies ACTH = Adrenal Corticotropic Hormone AF = Aunt Flo (menstruation)...
مقدمه: با توجه به ارتباط بین دهان و دندان و بیماری‌های سیستمیک و نقش قطعی عفونت‌های دهان و دندان در فرآیندهای پاتولوژیک در نقاط دیگر بدن، هدف از مطالعه حاضر بررسی اثر درمان غیر جراحی پریودنتال بر سطح سرمی آنتی بادی ضد کاردیولیپین (aCLA) است که به طور بالقوه در پاتوژنز بیماری های قلبی عروقی در بیماران پریودنتال نقش دارد.مواد و روش: بیست داوطلب (11 زن و 9 مرد) با میانگین سنی 55/40 سال در این مطالعه شرکت کردند. پریودنتیت مزمن با معاینه کامل پریودنتال تشخیص داده شد. این معاینات شامل اندازه گیری عمق پاکت (PD) و از دست رفتن چسبندگی (AL)، همچنین شاخص پلاک (PI) و شاخص لثه ای (GI) بود
Antiphospholipid antibody syndrome: Find the most comprehensive real-world symptom and treatment data on antiphospholipid antibody syndrome at PatientsLikeMe. 640 patients with antiphospholipid antibody syndrome experience fatigue, Pain, depressed mood, anxious mood, and insomnia and use Aspirin, Hydroxychloroquine, Warfarin, Enoxaparin, and Oxycodone to treat their antiphospholipid antibody syndrome and its symptoms.
Antiphospholipid antibodies occur in various clinical states, including the primary antiphospholipid syndrome. Clinical features in these conditions appear to be caused by vasculopathy associated with the presence of these antibodies.. We report the case of a patient with primary antiphospholipid syndrome who experienced cardiac necrosis secondary to myocardial microvasculopathy in the absence of vasculitis. This case demonstrates unequivocally that noninflammatory myocardial microvasculopathy occurs in the primary antiphospholipid syndrome per se without any clinical or immunologic signs of systemic lupus erythematosus or other disease process. The histopathologic findings in the skin and myocardial biopsies showed a noninflammatory vasculopathy characterized by bland thrombi and lack of infiltration of the vessel wall by inflammatory cells. Ultrastructural examination of the myocardial biopsy confirmed the vascular thrombosis and endothelial activation and showed no deposits in basement ...
How is Seronegative Antiphospholipid Antibody Syndrome abbreviated? SNAPS stands for Seronegative Antiphospholipid Antibody Syndrome. SNAPS is defined as Seronegative Antiphospholipid Antibody Syndrome rarely.
Antiphospholipid syndrome is an autoimmune disease, in which antiphospholipid antibodies (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common in women than in men. The exact cause is not known, but activation of the system of coagulation is evident. Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. The syndrome can be divided into primary (no underlying disease state) and secondary (in association with an underlying disease state) forms. Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with regulatory function upon the common pathway of coagulation (by degradating activated factor V). Lupus anticoagulant (LAC) antibodies bind to prothrombin, thus increasing its cleavage to thrombin, its active ...
This page includes the following topics and synonyms: Antiphospholipid Antibody Test, aPL Antibody, Antiphospholipid Antibodies, Antiphospholipid Antibody, Anticardiolipin Antibody Test, Anticardiolipin Antibody.
Donadini, MP, Crowther, M. Antiphospholipid syndrome: a challenging hypercoagulable state with systemic manifestations. Hematol-Oncol. vol. 24. 2010. pp. 669-76. (Recent concise review and update of this syndrome. Many of the clinical statistics were cited from this review.). Ruiz-Irastorza, G, Crowther, M, Branch, W, Khamashta, MA. Antiphospholipid syndrome. Lancet. vol. 376. 2010. pp. 1498-1509. (Along with the first listed reference, a key source for this chapter, especially with respect to treatment recommendations.). Frances, C. Dermatological manifestations of Hughes antiphospholipid antibody syndrome. Lupus. vol. 19. 2010. pp. 1071-77. (Current review of cutaneous manifestations.). Weinstein, S, Piette, W. Cutaneous manifestations of antiphospholipid antibody syndrome. Hematol Oncol Clinics N Am. vol. 22. 2008. pp. 67-77. (Relatively recent review of cutaneous findings.). Hughes, GRV. Antiphospholipid syndrome (Hughes syndrome): 10 clinical topics. Lupus. vol. 19. 2010. pp. ...
Antiphospholipid antibody syndrome (APS) is a recently-diagnosed syndrome presenting with arterial and venous thrombosis, recurrent miscarriages and thrombocytopenia in the presence of antiphospholipid antibodies. A 16- year-old man referred due to right sided chest pain, dyspnea and cyanosis of two fingers presented for 2 months. After a complete workup, diagnosis of pulmonary thromboembolism was confirmed through clinical examination, spiral chest CTscan and lower limb Doppler sonography. He had positive anticardiolipin antibody, lupus anticoagulant, ANA and anti dsDNA. Based on these findings, diagnosis of APS (probably secondary to SLE) was made. Symptoms were improved by anticoagulant, prednisolone and chloroquine therapy. In a conclusion, pulmonary embolism may be the first presentation of APS, especially in young adults. (Tanaffos 2008; 7(1): 71-74)
TY - JOUR. T1 - De novo infantile primary antiphospholipid antibody syndrome. AU - Alshekaili, J.. AU - Reynolds, G.. AU - Cook, M. C.. PY - 2010/11. Y1 - 2010/11. N2 - Most autoimmune diseases are rare in infants. Early onset can represent an extreme phenotype arising from strong genetic predisposition relatively independent of environmental influence. Alternatively, neonatal autoimmunity can arise from transplacental passage of maternal pathogenic IgG autoantibodies. Distinguishing between these possible explanations is crucial for determining the prognosis in the specific patient, and has important implications for understanding pathogenesis. We report a case of neonatal thrombotic stroke associated with both cardiolipin and β2-glycoprotein I antibodies in neonatal serum but absent from cord blood and maternal serum. While the child also carried one prothrombotic allele of factor V (Leiden allele), which may have contributed to the risk of thromboembolic disease, the serological analysis ...
Antiphospholipid antibody syndrome is a fascinatingly complex disorder. It is an autoimmune disease, whereby the immune system attacks our own tissues. This article summarises the basic mechanisms of the condition and main diseases it is involved in. Learn about the diverse effects antiphospholipid antibody syndrome (APS) can have, from heart attack to miscarriage and how APS can be treated.
Antiphospholipid Antibody Syndrome (APS) is a highly prevalent cause of antibody-mediated thrombosis manifesting in venous thrombosis (DVT and PE), arterial thrombosis (most commonly stroke), and pregnancy complications. The diagnosis of definite APS requires both clinical and laboratory criterion as established by the working group of the International Congress on Antiphospholipid Antibodies (based on expert opinion). Since thrombosis and pregnancy loss are common in the general population, and antiphospholipid antibodies (aPL) occurs in a small percentage of the healthy public, it is important to demonstrate antibody persistence in patients who have the proper clinical indications in order to avoid misdiagnosis. Unfortunately, laboratory testing in this area lacks standardization, resulting in wide inter-laboratory variance. However, due to the commercialization of tests and automation, inter-laboratory variance has improved. Data on several new non-criterion tests suggest that they may ...
Antiphospholipid Antibody Carriers - Antiphospholipid Antibody Syndrome. Rare Diseases of the Immune System - by Pier Luigi Meroni
BACKGROUND Antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by vascular thrombosis (arterial or venous) and/or pregnancy complications associated with the occurrence of autoantibodies, specifically lupus anticoagulant, anticardiolipin antibodies, and/or anti-β2 glycoprotein-I antibodies confirmed at least twice over a 12 week period according to the 2006 Sydney criteria. Antiphospholipid antibodies are encountered in the general population with a reported prevalence of 1% to 5% However, APS is far more infrequent with a prevalence of 40-50/100,000 persons and an incidence of about 5 new patients/100,000 persons. APS can be diagnosed in patients with no apparent clinical or laboratory pathology (primary APS) or it may be related to numerous other conditions, autoimmune diseases (usually systemic lupus erythematosus), malignancies, infections and drugs (secondary APS). Women are at risk for APS since the disease is encountered in both the primary and the secondary state
New life-saving treatments for Antiphospholipid syndrome in clinical trial on Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome
Mycoplasma penetrans, a rare bacterium so far only found in HIV-infected persons, was isolated in the blood and throat of a non-HIV-infected patient with primary antiphospholipid syndrome (whose etiology and pathogenesis are unknown).
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein 1 antibodies. APS can present with a variety of clinical phenotypes, including thrombosis in the veins, arteries and microvasculature as well as obstetrical complications. The pathophysiological hallmark is thrombosis, but other factors such as complement activation might be important. Prevention of thrombotic manifestations associated with APS includes lifestyle changes and, in individuals at high risk, low-dose aspirin. Prevention and treatment of thrombotic events are dependent mainly on the use of vitamin K antagonists. Immunosuppression and anticomplement therapy have been used anecdotally but have not been adequately tested. Pregnancy morbidity includes unexplained recurrent early miscarriage, fetal death and late obstetrical manifestation such as pre-eclampsia, premature birth or fetal ...
14:52 - The punchline: aHUS and TTP diagnosis algorithm. Publications. Stromsness B. et al. Physician Interpretation of Equivocal Results for aHUS Genetic Testing Varies Greatly and is Frequently at Odds with Laboratory Views. J Clin Apheresis. 2019; (abstract P-82).. Ero, MP, Kain, JS, inventors; Machaon Diagnostics, Inc., assignee. 2018 Dec 18. Method of diagnosis of complement-mediated thrombotic microangiopathies. United States patent US 10,155,983.. Tao J. et al. A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis. BMC Nephrology. 2018;19:355.. Kain J. et al. Additional Genes Associated with Atypical Hemolytic Uremic Syndrome. ASN 2018 Abstract TH-PO713. 2018; (abstract).. Switala L. et al. Complement factor abnormalities detected in patients with suspected Heparin-induced Thrombocytopenia (HIT) but not in Thrombotic Thrombocytopenia Purpura (TTP). ISLH 2017 Abstract Proceedings. 2017; (abstract).. Ipe T. et al. An extremely rare ...
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Sources Used in Current Review. Berg, T. (Updated 2015 April 15). Antiphospholipid syndrome and pregnancy. Medscape. Available online at http://emedicine.medscape.com/article/261691-overview. Accessed 2/15/2017.. (Reviewed 2016 March 21). Antiphospholipid syndrome. Lupus Foundation of America. Available online at http://www.lupus.org/answers/entry/antiphospholipid-syndrome. Accessed 2/15/2017.. Movva, S. (Updated 2016 July 1). Antiphospholipid syndrome workup. Medscape. Available online at http://emedicine.medscape.com/article/333221-workup. Accessed 2/15/2017.. Moake, J. (Revised 2016 September) Antiphospholipid antibody syndrome. Merck Manual Professional Version. Available online at http://www.merckmanuals.com/professional/hematology-and-oncology/thrombotic-disorders/antiphospholipid-antibody-syndrome-aps. Accessed 2/15/2017.. (Updated 2016 December). Antiphospholipid syndrome - APS. ARUP. Available online at http://www.arupconsult.com/Topics/APS.html?client_ID=LTD. Accessed 2/15/2017.. (© ...
Blood. 117(25), 6939-6947. Agar C, de Groot PG, Marquart JA & Meijers JCM. (2011b) Evolutionary conservation of the LPS binding site of beta2-glycoprotein I. Thromb Haemost. In press. Arad A, Proulle V, Furie RA, Furie BC & Furie B. (2011) β₂-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model. Blood. 117(12), 3453-3459. Bevers EM & Galli M. (1990) Beta 2-glycoprotein I for binding of anticardiolipin antibodies to cardiolipin. Electron microscopy analysis of β2GPI. , 2010). Analysis of EM pictures showed that more than 99% of plasma β2GPI was in a closed conformation. These observations suggested that plasma β2GPI circulates in a circular (closed) conformation, whereas after interaction with antibodies β2GPI undergoes a major conformational change into a fishhook-like (open) structure. , 1996). When antibodies toward β2GPI were added to plasma, clotting times prolonged in a β2GPI-dependent ...
TY - JOUR. T1 - Use of fondaparinux in a patient with antiphospholipid antibody syndrome and heparin-associated thrombocytopenia [9]. AU - Holtan, Shernan G.. AU - Knox, S. K.. AU - Tefferi, Ayalew. PY - 2006/7. Y1 - 2006/7. UR - http://www.scopus.com/inward/record.url?scp=33745225893&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=33745225893&partnerID=8YFLogxK. U2 - 10.1111/j.1538-7836.2006.01961.x. DO - 10.1111/j.1538-7836.2006.01961.x. M3 - Article. C2 - 16839370. AN - SCOPUS:33745225893. VL - 4. SP - 1632. EP - 1634. JO - Journal of Thrombosis and Haemostasis. JF - Journal of Thrombosis and Haemostasis. SN - 1538-7933. IS - 7. ER - ...
The Antiphospholipid Antibody Syndrome Market is expected to grow at a CAGR of 8.31% and is poised to reach US$XX Billion by 2027 as compared to US$XX
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The objective of this study was to highlight the need for investigation of antiphospholipid (aPL) antibodies in patients presenting with myocardial infarction (MI) and normal coronary arteries at angiography. We present five patients who were found to have had an MI without evidence of atherosclerosis. All had aPL antibodies and thus fulfilled the diagnosis of antiphospholipid syndrome (APS). Who did not have recurrent events on long-term anticoagulation maintaining an international normalised ratio of 3-4. This study suggests that APS is probably a major cause of MI in those with normal coronary arteries at angiography. It is an important diagnosis to make as they do not require anti-atherosclerotic treatment but appear, from this case series, to do well on high-dose warfarin. Further clinical studies are necessary to look at prevalence and best management in these patients.
Adams, MJ, Donohoe, S, Mackie, IJ and Machin, SJ 2001 , Anti-tissue factor pathway inhibitor activity in patients with primary antiphospholipid syndrome , British Journal of Haematology, vol. 114 , pp. 375-379 , doi: 10.1046/j.1365-2141.2001.02923.x. ...
Abscess excision Acute myelogenous leukemia (AML) Additional / adjuvant therapy ALCL Anal cancer anaplastic large-cell lymphoma Anemia and iron deficiency Anticardiolipin antibodies Antiphospholipid antibodies Antithrombin III deficiency aplastic anemia Aromatase Inhibitors B12 deficiency Bladder cancer blood diseases blood transfusions Bone density testing bone marrow aspiration bone marrow biopsy Breast cancer cancer care Chemoprevention Chemotherapy Chemotherapy clinical trials Chemotherapy side effect support Chronic lymphocytic leukemia (CLL) Chronic myelogenous leukemia (CML) CMML Colon cancer complete blood count cooleys anemia CT cutaneous ALCL Cyst excision Deep vein thrombosis (DVT) Diffuse large B-cell lymphoma Duodenal cancer Esophageal cancer Esophageal tumors ET extreme fatigue Factor 5 Leiden Follicular lymphoma frequent bruising frequent fever frequent nosebleed Gallbladder cancer / carcinoma Gastric cancer Head and neck cancer Hemachromatosis hemoglobin H disease hemophilia ...
TY - JOUR. T1 - Clinical evaluation of insulin resistance and β-cell function by the homeostasis model assessment in patients with systemic lupus erythematosus. AU - Tso, Tim K.. AU - Huang, Hui Yu. AU - Chang, Chen Kang. AU - Huang, Wen Nan. AU - Liao, Ying Ju. PY - 2004/10/1. Y1 - 2004/10/1. N2 - The aim of this preliminary study was to evaluate insulin resistance and secretion using homeostasis model assessment (HOMA) in patients with systemic lupus erythematosus (SLE). The fasting glucose and insulin concentrations, HOMA insulin resistance (IR), HOMA β-cell, antidouble-stranded DNA antibodies (anti-dsDNA), C3, C4, and SLE disease activity index (SLEDAI) were determined in a total of 58 female SLE patients. All patients were classified into subgroups according to the presence of anticardiolipin antibodies (aCL + vs. aCL-) and SLEDAI scores (SLEDAI , 3 vs. SLEDAI , 3). Results showed that SLE patients with and without aCL had significantly higher fasting insulin levels, HOMA IR, and HOMA ...
Results. Twenty-one patients were included. Diagnosis of BD was based on the criteria of the International Study Group for BD. Main locations for thrombosis were the cerebral sinuses, in 11 patients (52.4%); and lower limbs, in 9 patients (40.9%). Recurrent episodes were observed in 4 patients (21%). Thrombophilia measurements were normal in 14 patients out of 21, while anticardiolipin antibodies were positive in 4 patients, and 2 out of 21 had protein C deficiency. One patient had lupus anticoagulant. All patients were treated with colchicine. Corticosteroids were also added for variable periods in 13 patients. Five patients out of 21 were treated with anticoagulants (heparin, then anti-vitamin K) and 3 with antiplatelets (acetylsalicylic acid). ...
Fingerprint Dive into the research topics of Antiphospholipid antibody syndrome mimicking multiple sclerosis clinically and by magnetic resonance imaging. Together they form a unique fingerprint. ...
By Kristin Bendikson, MD. When a woman has a miscarriage, she often feels isolated and alone. Miscarriages are more common than most people realize, however; and when women start talking with their friends, they often find that they are not alone in coping with this difficult experience.. A miscarriage-the early loss of a pregnancy-occurs in approximately 15 percent of all clinically recognized pregnancies. If all pregnancies are accounted for, the statistic is closer to 50 percent ending in a loss. The increase is due to the fact that many women dont even know they are pregnant and experience their period at the normal time or just a few days late. Sometimes a woman knows she is having a miscarriage because she has symptoms, which might include bleeding and cramping followed by the passage of the pregnancy. Other times a woman doesnt sense there is anything wrong at all, and she finds out that the pregnancy has stopped growing only when she sees her doctor for an ultrasound.. Its important ...
2322 Rayburn House Office Building. Introduction. Chairman Pitts, Ranking Member Pallone, and members of the Subcommittee, the American Clinical Laboratory Association (ACLA) is pleased to have this opportunity to testify at todays hearing, 21st Century Cures: Examining the Regulation of Laboratory- Developed Tests.. ACLA is a not-for-profit association representing the nations leading providers of clinical laboratory services, including local, regional, and national laboratories. Our diverse membership represents a broad array of clinical laboratories, includes large national independent labs, reference labs, esoteric labs, hospital labs, and nursing home laboratories. ACLA members are actively engaged in the creation and performance of innovative and much-needed Laboratory-Developed Tests (LDTs) that have helped to transform the standard of clinical care in this country and provide great hope for further improvements in the future.. ACLA and its member laboratories are committed to ...
A look at antiphospholipid antibody syndrome, what laboratory tests can support the diagnosis of this syndrome, what are the causes and how is it treated. ...
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These results indicate that aPL induced by immunization with a phospholipid-binding CMV peptide are pathogenic in vivo. The results also suggest a mechanism (molecular mimicry) by which pathogenic aPL may be generated in patients with antiphospholipid syndrome.
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Is there anyone in here with a child who has Antiphospholipid Antibody Syndrome? My daughter was diagnosed at age 10. Now shes almost 12. It would just be nice...
We report in Figure 2 the annual rate (∼ 0.4%) of first cardiovascular event (including VTE) in normal white population at 35 to 55 years of age,14 that (1.36%) of 125 single aPL positive carriers with a mean age of 41 years (data taken by a recently published study by our group),15 and that (5.3%) of triple-positive carriers of this study (mean age, 45 years). Annual rate in a cohort of SLE patients half of whom had aPL was 2.9 per 100 patient-years.16 Hence, because less than half of our cohort had autoimmune disorders, the higher incidence of TEs recorded in this study may be related to the selection of high-risk aPL-positive population. Likewise, in patients with APS and triple positivity,7 TEs were equally distributed among arterial and venous circulation. Some patients in this study were treated with aspirin for primary thromboprophylaxis, behavior that did not lead to a significant reduction of events. To our knowledge, only one prospective clinical trial addresses the question of ...
My husband and I lost our baby boy last June and are thinking about trying again. My husband and family members are a little nervous about the thought of trying again. I have to tell you I am nervous too. I was so sick and out of it that I really have little or no memory of what when on around me. I had eclampsia and HELLP at 21 weeks. After having testing done I found out I have anticardiolipin and a high rheumatoid factor. We wanted to see if anyone in the Ohio group is from Columbus and has visted a MFM or high risk doctor and what you thought of them. I think due to the rules of the website you will have to e-mail me with your response because we can not name doctors or hospital in the forums. ...
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Sindroma Antiphospholipid (APS) - eshte nje semundje autoimmune karakterizuar nga perpunimin e sasive te medha te antitrupave me fosfolipide - strukturat kimike të cilat janë ndërtuar të qelizave...
Anticardiolipin antibodies[edit]. Anti-cardiolipin antibodies can be detected using an enzyme-linked immunosorbent assay (ELISA ... since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a ... Antiphospholipid syndrome is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and ... Patients with both Lupus anticoagulant antibodies and moderate/high titre anticardiolipin antibodies show a greater risk of ...
"HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with ... "HLA class II alleles associations of anticardiolipin antibodies". Lupus. 9 (1): 47-55. doi:10.1177/096120330000900109. PMID ... DRB1*04:02: drug-triggered/idiopathic pemphigus vulgaris, type 1 diabetes, SLE associated anti-cardiolipin and anti-β2 ... glycoprotein I. DRB1*04:03: polycystic ovary syndrome, SLE associated anti-cardiolipin and anti-β2 glycoprotein I. DRB1*04:04: ...
... a rare manifestation of Graves hyperthyroidism associated with anticardiolipin antibodies". South. Med. J. 97 (6): 601-3. doi: ... or blood tests for antibodies associated with antiphospholipid syndrome or systemic lupus erythematosus. Other than identifying ... "Livedo Vasculopathy Associated with IgM Anti-phosphatidylserine-prothrombin Complex Antibody". Acta Dermato Venereologica. 90 ( ... sarcoidosis and Sjögren's syndrome Livedo vasculopathy associated with IgM antiphosphatidylserine-prothrombin complex antibody ...
... and anticardiolipin antibodies.[citation needed] The erythrocyte sedimentation rate and C reactive protein levels tend to be ...
Takayasu arteritis is not associated with ANCA, rheumatoid factor, ANA, and anticardiolipin antibodies. Most people with ...
... anticardiolipin antibodies, thrombophilia, and hypofibrinolysis". J Lab Clin Med. 127 (5): 481-8. doi:10.1016/S0022-2143(96) ...
The two antibodies implicated are anticardiolipin and lupus anticoagulant. Anticardiolipin antibodies attach to the endothelial ... Anti-neuronal antibodies. The three identified anti-neuronal antibodies postulated in CNS involvement are the lympho-cytotoxic ... These antibodies also correlate with cognitive and visual spatial defects. Second, the anti-neuronal membrane antibodies are ... These antibodies are seen in 90% of SLE patients with psychosis. Antiphospholipid antibodies. ...
Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... It therefore detects anti-cardiolipin antibodies (IgG, IgM or IgA), visualized through foaming of the test tube fluid, or " ... The syphilis anti-cardiolipin antibodies are beta-2 glycoprotein independent, whereas those that occur in antiphospholipid ... "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but ...
Shi W, Chong BH, Hogg PJ, Chesterman CN (1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of ... Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... systemic lupus erythematosus (SLE)). Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune ... glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody ...
These antibodies are usually picked up in young women with recurrent spontaneous abortions. In anti-cardiolipin-mediated ... Patients with anti-cardiolipin antibodies (Antiphospholipid syndrome) can have recurrent thrombotic events even early in their ... Hokama Y, Campora CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K. Anticardiolipin antibodies in the sera of patients with ... Anti-cardiolipin antibodies can also be increased in numerous other conditions, including systemic lupus erythematosus, malaria ...
An Enzyme-Linked ImmunoSorbent Assay (ELISA) test is done to detect anticardiolipin antibodies' presence in the blood. ... Positive test are often repeated due to the fact that antilipid antibodies can be present in the body for short stints due to ... The syndrome is caused by antiphospholipid antibodies that target a group of proteins in the body that are associated with ... These antibodies activate endothelial cells, platelets, and immune cells, ultimately causing a large inflammatory immune ...
In SLE, LSE has been linked to pericarditis, presence of anticardiolipin antibodies, arterial and venous thromboses, and ...
2000). "HLA class II alleles associations of anticardiolipin and antibeta2GPI antibodies in a large series of European patients ... acute necrotizing encephalopathy DRB3*0301 is weakly associated with anticardiolipin antibodies in SLE DRB3*0301:DRB1*1302 may ... "Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly ... serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, ...
Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis.[ ... Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE ... These antibodies clump into antibody-protein complexes which stick to surfaces and damage blood vessels in critical areas of ... Simplest classification tree: SLE is diagnosed if a person has an immunologic disorder (anti-DNA antibody, anti-Smith antibody ...
Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis.[ ... Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE ... and anti-histone antibodies (which are linked to drug-induced lupus). Anti-dsDNA antibodies are highly specific for SLE; they ... The anti-dsDNA antibody titers also tend to reflect disease activity, although not in all cases. Other ANA that may occur in ...
... headaches in SLE and associated Raynaud's phenomenon and/or anti-cardiolipin antibodies. Further studies are needed however to ... Annese V, Tomietto P, Venturini P, D'Agostini S, Ferraccioli G (2006). "[Migraine in SLE: role of antiphospholipid antibodies ...
The presence of anticardiolipin antibodies is a more serious risk factor for the disease, as well as the presence of more ... Anti-RNP antibodies in elevated levels, especially antibodies against protein 68 kD. Absence of severe renal or CNS disease. ... SLE, scleroderma, and in MCTD have antibodies against anti-U1-snRNP at differing percentages. These antibodies are in most MCTD ... Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. After the ...
"Identification of a region of β2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity" ( ... "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but ... and a region recognized by anticardiolipin antibodies" (1994) Journal of Immunology, 152 (2), pp. 653-659. Cited 195 times. ... McNeil, H.P., Chesterman, C.N., Krilis, S.A. "Immunology and clinical importance of antiphospholipid antibodies" (1991) ...
Aortic dissection Anti-cardiolipin antibodies CMV infection Herpetic infection Hyperglycemia Hypersensitivity to broad-spectrum ...
... syndrome Polycythemia Hypercoagulability Protein C deficiency Antiphospholipid antibodies Anticardiolipin antibodies Lupus ... "Amaurosis fugax associated with antiphospholipid antibodies". Annals of Neurology. 25 (3): 228-32. doi:10.1002/ana.410250304. ...
... anti-cardiolipin antibodies, and anti-β2-glycoprotein 1 antibodies; it is therefore regarded as an autoimmune disease. In some ... The risk is determined by the subtype of antibody detected, by the antibody titer (amount of antibodies), whether multiple ... anti-cardiolipin antibody, anti-β2 glycoprotein 1 antibody, activated protein C resistance, fibrinogen tests, factor V Leiden ... Recurrent miscarriage is an indication for thrombophilia screening, particularly antiphospholipid antibodies (anti-cardiolipin ...
... is an acronym that may refer to: Anti-cardiolipin antibodies Allegheny County Library Association, a library association ...
... acid Advisory Committee for Aeronautics Anterior cerebral artery Anti-cardiolipin antibodies Anti-centromere antibodies ...
... the other component being the serological testing for anticardiolipin antibodies and anti-β2 glycoprotein-I antibodies using ... Antiphospholipid antibody syndrome is an important marker for recurrent thrombosis, and often warrants indefinite anticoagulant ... This makes the test sensitive to the presence of lupus anticoagulants, because these antibodies interfere with the clot- ... The dRVVT is one component of a workup of a suspected antiphospholipid antibody, ...
... lupus anticoagulant is generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and ... In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of ... Its name is a misnomer, as it is actually a prothrombotic antibody. Lupus anticoagulant in living systems cause an increase in ... The name derives from their properties in vitro, as these antibodies increase laboratory coagulation tests such as the ...
... a common occurrence among participants of several sports Anti-cardiolipin antibodies Administration for Community Living Adult ...
... and anticardiolipin antibodies. Neonatal lupus is the occurrence of lupus symptoms in an infant born from a mother with lupus, ... Women pregnant and known to have anti-Ro (SSA) or anti-La antibodies (SSB) often have echocardiograms during the 16th and 30th ... are recommended to be screened for antiphospholipid antibodies, both the lupus anticoagulant (the RVVT and sensitive PTT are ...
A meta-analysis published in 2020 identified that the prevalence of antiphospholipid antibodies including anticardiolipin (Odds ... The anti-HSP60 and anti-HSP65 antibodies that target HSPs produced by Streptococci (including S. sanguinis and S. pyogenes) and ... Tanaka, T.; Yamakawa, N.; Koike, N.; Suzuki, J.; Mizuno, F.; Usui, M. (June 1999). "Behçet's disease and antibody titers to ... Islam, Md Asiful (2020). "Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis ...
... also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These ... Shi W, Chong BH, Hogg PJ, Chesterman CN (1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of ... This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies that specifically ... 2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ...
... anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to ... Anti-mitochondrial antibody. *Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA ... This pattern is associated with anti-dsDNA antibodies, antibodies to nucleosomal components, and anti-histone antibodies. There ... antibodies are antibodies to components of the nuclear membrane and are found in primary biliary cirrhosis (PBC). Each antibody ...
Anti-mitochondrial antibody. *Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA ... Antibody mimetic[edit]. Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens. They are ... Asymmetrical antibodies[edit]. Heterodimeric antibodies, which are also asymmetrical and antibodies, allow for greater ... How Lymphocytes Produce Antibody from Cells Alive!. *Antibody applications Fluorescent antibody image library, University of ...
Anti-mitochondrial antibody. *Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA ... Approximately only 0.1 to 0.5 percent of the general population has the antibody.[citation needed] ... Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55-63. doi:10.1080/ ... Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC ...
抗心磷脂(英語:Anti-cardiolipin antibodies). 抗細胞質抗體. *抗中性白血球細胞質抗體/ANCA(英語:Anti-neutrophil cytoplasmic antibody) *C-ANCA(英語:C-ANCA) ... 抗體(antibody),又稱免疫球蛋白(immunoglobulin,簡稱Ig)[1],是一種主要由漿細胞分泌,被免疫系統用來鑑別與中和外來物質如細菌、病毒等病原體的大型Y形蛋
... antibodies, antiphospholipid MeSH D12.776.377.715.548.114.323.210.100 - antibodies, anticardiolipin MeSH D12.776.377.715. ... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... antibodies, bispecific MeSH D12.776.377.715.548.114.143 - antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, ... antibodies, helminth MeSH D12.776.377.715.548.114.191 - antibodies, heterophile MeSH D12.776.377.715.548.114.224 - antibodies, ...
... antibodies, antiphospholipid MeSH D12.776.124.486.485.114.323.210.100 - antibodies, anticardiolipin MeSH D12.776.124.486. ... antibodies, antiphospholipid MeSH D12.776.124.790.651.114.323.210.100 - antibodies, anticardiolipin MeSH D12.776.124.790. ... antibodies MeSH D12.776.124.486.485.114.071 - antibodies, anti-idiotypic MeSH D12.776.124.486.485.114.089 - antibodies, ... antibodies, bispecific MeSH D12.776.124.486.485.114.143 - antibodies, blocking MeSH D12.776.124.486.485.114.167 - antibodies, ...
The presence of the autoantibodies anti-dsDNA, anti-Sm, and anti-cardiolipin has been shown to correlate with the development ... antibodies. It is estimated that up to 25 percent of people with systemic autoimmune disease could be considered to have UCTD. ...
Anti-cardiolipin antibodies are another type of AMA, and cardiolipin is found on the inner mitochondrial membrane. A cause of ... M1 - cardiolipin (Anti-cardiolipin antibodies, ACA) M2 - branched-chain alpha-keto acid dehydrogenase complex M3 - outer ... had anti-transglutaminase antibodies, usually associated with coeliac disease. Antibodies Mitochondrion MedlinePlus ... and non-species-specific anti-organelle antibody detected by immunofluorescence: the mitochondrial antibody number 5. Clin Exp ...
Anticardiolipin antibodies are the result of an autoimmune disorder where your body makes antibodies against its own tissues. ... Anticardiolipin Antibodies Tracey__0 I am a 25 year old woman. I consider myself to be physically and mentally fit, I guess ... Whether you are at risk of death from this disorder is hard to determine, but most patients with anticardiolipin antibodies are ... these chemicals cannot prevent clots from developing in the placental blood vessels from the anticardiolipin antibodies. These ...
A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute ... On lab workup, it was found that she was "positive (for) anticardiolipin IgM and anticardiolipin IgG phospholipid antibodies". ... Anticardiolipin antibodies and COVID-19. News-Medical. https://www.news-medical.net/news/20200610/Anticardiolipin-antibodies- ... A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute ...
They are a form of anti-mitochondrial antibody. In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present ... Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including ... Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with ... because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. Anti- ...
... an antibody that is directed against phospholipids and especially cardiolipin and is associated with increased risk for ... recurring arterial and venous thromboses -called also anticardiolipin. ... Share anticardiolipin antibody. Post the Definition of anticardiolipin antibody to Facebook Share the Definition of anticardio ... Comments on anticardiolipin antibody. What made you want to look up anticardiolipin antibody? Please tell us where you read or ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ... Anti-Cardiolipin Antibodies, IgG & IgM. 2. Anti-Cardiolipin Antibody, IgG. 3. Adenovirus Antibody, IgG. 4. Adenovirus Antibody ... Anti-dsDNA Antibody, IgG. 7. Anti-GBM Antibody, IgA (IFA). 8. Anti-GBM Antibody, IgG (IFA). 9. Anti-GBM Antibody, IgG (ELISA). ... Anti-Glomerular Basement Membrane Antibody, IgA (IFA). 11. Anti-Glomerular Basement Membrane Antibody, IgG (ELISA). ...
... antibody is important in diagnosing antiphospholipid syndrome (APS). According to the Second International Anti-cardiolipin ... encoded search term (Anticardiolipin Antibody) and Anticardiolipin Antibody What to Read Next on Medscape. Related Conditions ... Anticardiolipin (aCL) antibody of immunoglobulin G (IgG) and/or immunoglobulin M (IgM) isotype present in serum (,40 GPL or MPL ... Consensus guidelines on anti-cardiolipin antibody testing and reporting. Pathology. 2004 Feb. 36(1):63-8. [Medline]. ...
This time the lupus anticoagulant came back negative, but this time the anticardiolipin antibodies came back pos. Doc says to ... HealingWell.com Forum , Diseases & Conditions , Lupus , anticardiolipin antibodies Select A Location. ****** Top of the Forum ... These together can help greatly with some lesser symptoms such as brain fog when it is due to these antibodies.. I would be far ... Either the anticardiolipin tests or the lupus anticoagulant can be positive at any time or negative. Thats why both tests are ...
Degos disease: association with anticardiolipin antibodies and the lupus anticoagulant. Br Med J (Clin Res Ed) 1984; 289 :576 ... Degos disease: association with anticardiolipin antibodies and the lupus anticoagulant.. Br Med J (Clin Res Ed) 1984; 289 doi ...
Anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) have been detected in patients with hepatitis C virus (HCV) ... Lupus anticoagulant, anticardiolipin antibodies and hepatitis C virus infection in thalassaemia Br J Haematol. 1998 Sep;102(4): ... Anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) have been detected in patients with hepatitis C virus (HCV) ... None of patients developed any complications related to antiphospholipid antibodies (APL); therefore the clinical significance ...
A high level of anticardiolipin antibody activity was detected among 19.23% of the habitual aborters but in none of the ... Daboubi, M.K. (‎2001)‎. Anticardiolipin antibodies in women with recurrent abortion. EMHJ - Eastern Mediterranean Health ... Enzyme-linked immunosorbent assay was used for detection of anticardiolipin antibodies in a group of 26 patients defined as ... The present study sought to determine whether the level of anticardiolipin antibodies in women with recurrent abortion differed ...
Anticardiolipin Antibodies and Hypercoagulability Matthew H. Liang, MD; Charles H. Hennekens, MD; Meir J. Stampfer, MD ... Anticardiolipin Antibodies and Hypercoagulability. Ann Intern Med. 1993;118:986-987. doi: 10.7326/0003-4819-118-12-199306150- ... Hess lists several potential reasons why we were not able to detect an association between anticardiolipin antibodies and risk ... Although an association between anticardiolipin antibodies and ischemic stroke cannot be ruled out, as we noted in our paper, ...
Livedoid vasculitis with anticardiolipin antibodies: improvement with danazol. Authors. *. Wakelin,. * St Johns Institute of ...
1998) Anticardiolipin antibodies are frequently present in patients with idiopathic intracranial hypertension. Arch Neurol 55: ... Israeli prevalence of anticardiolipin antibodies was 3%-5%; APCR 5%-8%; protein C deficiency ,1%; protein S deficiency ,1%, ... The association of idiopathic intracranial hypertension (IIH) or pseudotumour cerebri (PTC) with anticardiolipin antibodies ( ... Anticardiolipin IgG and IgM antibodies were determined by a semiquantitative ELISA assay (Reads,USA). ...
Idiopathic intracranial hypertension and anticardiolipin antibodies Message subject: (Your Name) has forwarded a page to you ...
Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia Cesare Masala, MD; Maurizio Sorice, MD; Maria A. Di Prima, MD; ... To the Editor: Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with ... We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among ... Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia. Ann Intern Med. 1989;110:749. doi: https://doi.org/10.7326/0003- ...
Thirty (21%) had raised anticardiolipin antibody levels compared with only three in 98 age matched controls. The highest ... The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. ... while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. This ...
If you are a society or association member and require assistance with obtaining online access instructions please contact our Journal Customer Services team ...
Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease. TJ Hendra, EN Harris, RC Trembath, GRV Hughes, JS ... Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease. TJ Hendra, EN Harris, RC Trembath, GRV Hughes, JS ... Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease Message Subject (Your Name) has forwarded a page to ...
... and anticardiolipin antibodies (ACA) and their relationship to each other in a healthy population of 499 blood donors. Plasma ... Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population Aust N Z J Med. 1990 Jun;20(3):231-6. ... This study was designed to explore the incidence of lupus anticoagulant (LA) and anticardiolipin antibodies (ACA) and their ... Neither ACA nor LA were associated with antinuclear antibodies (ANA) or rheumatoid factor (Rh factor). Thus, in a healthy ...
... in the presence of anticardiolipin antibodies). The suppression of lymphocyte proliferation by anticardiolipin antibodies was ... Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles ... These newly found activities of anticardiolipin antibodies were mediated by the non-specific membranotropic property of the ... These results suggest that anticardiolipin antibodies exert inhibitory effects on both lymphocytes and phagocytes in addition ...
A case of optic neuritis associated with anticardiolipin antibodies]. Rinsho Shinkeigaku. 1992 Mar; 32(3):330-2. ...
IgM anticardiolipin antibodies in human serum or plasma. Order the test online through Personalabs today! ... Anticardiolipin antibodies, IgA, quantitative - TC - 7352. Anticardiolipin antibodies, IgG, quantitative. Anticardiolipin ... Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome. Individuals with the ... This test measures the level of IgA, IgG, IgM anticardiolipin antibodies in human serum or plasma. Order the test online ...
Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase ... Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase ... Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly ... Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL ...
Antiphospholipid Antibodies in Stroke Study (APASS) group. Anticardiolipin antibodies are an independent risk factor for first ... Matsuura E. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol. 1992;148:3885-3891. ... Antiphospholipid Antibodies in Stroke Study (APASS) group. Anticardiolipin antibodies and the risk of recurrent thrombo- ... Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome and with ...
Affinity-purified anticardiolipin antibody (ACA) preparation. The ACAs of IgG and IgM classes were purified from a reactive ... Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis ... Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis ... Analytical sensitivity determined with IgM anticardiolipin antibody (ACA) was 2.6 µg/mL for both NT-MAA and RPR, while IgG ACA ...
In conclusion, anticardiolipin antibodies are frequently found in patients with chronic hepatitis C and in these patients they ... Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid ... Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid ... In this study anticardiolipin antibodies (immunoglobulin G [IgG] isotype) were determined in serum from 100 patients with ...
It is a Custom assay which can detect Anti-Cardiolipin antibody (IgM) down to 0.375 Nanograms per millilter. ... Anti-Cardiolipin antibody (IgM) ELISA Kit LS-F41209 is a 96-Well enzyme-linked immunosorbent assay for the Quantitative ... Popular Anti-Cardiolipin antibody (IgM) Elisa Kits. Human Anti-Cardiolipin antibody (IgM) ELISA Kit (Indirect ELISA) - LS- ... Guinea pig Anti-Cardiolipin antibody (IgM) ELISA Kit (Custom ELISA) - LS-F41208 ...
... ELISA method for quantitative determination of Anti-Cardiolipin / Anti ... Rat Antibodies Rat Cytokines Rat ELISA Antibody Pairs Rat ELISA KIts Rat ELISPOT Kits Rat ELISPOT Antibody Pairs ... Human Antibody Human Cytokine Flurospot Kit Human ELISA Antibody pair Human ELISA Kits Human ELISPOT Antibody pairs Human ... Monkey Antibodies Monkey ELISA Antibody Pair Monkey ELISA kit Monkey ELISPOT Antibody Pair Monkey ELISPOT Kit Monkey Cytokine ...
Publications] T.Koike.: Anticardiolipin antibodies and β_2-glycoprotein I. Clin Immunol Immunopathol. 72. 187-192 (1994). *. ... Publications] T.Koike.: Anticardiolipin antibodies and β2-glycoprotein I. Clin Immunol Immunopathol.72. 187-192 (1994). *. ... Publications] T.Koike: Anticardiolipin antibodies and beta2-glycoprotein I. Clin Immunol Immunopathol. 72. 187-192 (1994). * ... Publications] Y.Kita,T.Sumida,I.Iwamoto,Y.Yoshida,T.Koike: V gene analysis of anti-cardiolipin antibodies from (NZW x BXSB) Fl ...
Anticardiolipin antibodies in systemic lupus erythematosus: clinical and laboratory correlations Am J Med (Dec) 99:624-628 1995 ... Prolonged PTT should be used rather than elevated anticardiolipin antibodies for identifying SLE patients with a high risk of ... A prospective cohort study in a single center examined the link between anticardiolipin antibodies and features of the ... These results contrast with findings in patients with anticardiolipin antibodies without SLE (primary antiphospholipid syndrome ...
  • Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis. (wikipedia.org)
  • Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and pregnancy morbidity in the presence of antiphospholipid antibodies (APLA). (medscape.com)
  • Circulating anticardiolipin autoantibodies (aCL-Abs) may be associated with recurrent abortions, deep vein thrombosis, systemic lupus erythematosus, and cerebrovascular accidents. (bmj.com)
  • Individuals with the antiphospholipid antibody syndrome (APS) have an increased risk for stroke, myocardial infarction, venous thrombosis, thromboembolism, thrombocytopenia, and/or recurrent miscarriages. (personalabs.com)
  • In conclusion, anticardiolipin antibodies are frequently found in patients with chronic hepatitis C and in these patients they may be implicated in the occurrence of thrombosis and in the development of thrombocytopenia. (cun.es)
  • Anticardiolipin antibody and the development of arterial and venous thrombosis. (nii.ac.jp)
  • A prospective cohort study in a single center examined the link between anticardiolipin antibodies and features of the antiphospholipid syndrome (thrombocytopenia, prolonged PTT, positive direct Coombs test, arterial and venous thrombosis, spontaneous abortions, vasculitic skin ulcers, livedo reticularis, and renal disease) in SLE patients. (hdcn.com)
  • Prolonged PTT should be used rather than elevated anticardiolipin antibodies for identifying SLE patients with a high risk of thrombosis. (hdcn.com)
  • The link between prolonged PTT and thrombosis may indicate that only those antibodies with lupus anticaogulant activity are pathogenic. (hdcn.com)
  • These results contrast with findings in patients with anticardiolipin antibodies without SLE (primary antiphospholipid syndrome), in whom the presence of antibodies is predictive of thrombosis. (hdcn.com)
  • The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two antibody blood tests spaced at least three months apart that confirm the presence of either lupus anticoagulant or anti-β 2 -glycoprotein-I (since β 2 -glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a less specific proxy). (wikipedia.org)
  • Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. (wikipedia.org)
  • Presence of these antibodies increases the risk of arterial thrombosis, venous thrombosis, thrombocytopenia and recurrent miscarriage. (machaondiagnostics.com)
  • Persistently elevated levels of ACL antibodies are associated with an increased risk of vascular thrombosis and obstetrical complications [3, 4]. (machaondiagnostics.com)
  • IgA antiphospholipid antibodies are an independent risk factor for thrombosis. (machaondiagnostics.com)
  • The presence of anticardiolipin antibodies increases the risk of blood clots, which can form in both arteries and veins, giving rise to conditions like stroke and deep vein thrombosis (DVT). (fertilitysmarts.com)
  • Antiphospholipid syndrome (or antiphospholipid antibody syndrome) is a disorder of coagulation which causes thrombosis in both arteries and veins, as well as recurrent miscarriage. (dailystrength.org)
  • Antiphospholipid syndrome (APS) is an autoimmune disease, characterized by thrombosis and pregnancy complications with persistently elevated levels of antiphospholipid antibodies (aPL). (intechopen.com)
  • This new approach in the diagnosis of APS leads to the assessment of the risk of thrombosis considering the results of different aPL (lupus anticoagulants (LA), anticardiolipin antibodies (aCL), antibodies against β2GPI (anti-β2GPI), and phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) (isotypes IgG and IgM). (intechopen.com)
  • Anticardiolipin antibodies which are antiphospholipid antibodies by decreasing the prostacyclin production may damage the vascular endothelium and cause thrombosis in the vessels. (elsevier.com)
  • Antiphospholipid syndrome (APS or APLS) or antiphospholipid antibody syndrome is a disorder of coagulation that causes blood clots ( thrombosis ) in both arteries and veins as well as pregnancy-related complications such as miscarriage , stillbirth , preterm delivery , or severe preeclampsia . (thefullwiki.org)
  • Identification of these cases prompted a retrospective analysis for the presence of IgG anticardiolipin antibody, the most useful laboratory marker of vascular thrombosis in the antiphospholipid syndrome. (nih.gov)
  • Anticardiolipin IgG was present in 2/21 (8.8%) recipients who developed a hepatic vessel thrombosis following liver transplantation, compared to 7/111 (6.3%) (p=0.59) in whom transplantation was not complicated by hepatic vessel thrombosis. (nih.gov)
  • The presence of IgG anticardiolipin antibody was uncommon in recipients following liver transplantation and was not associated with an increased risk of hepatic vessel thrombosis. (nih.gov)
  • The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and obstetric complications (miscarriages, stillbirths). (clinicaltrials.gov)
  • The primary aim of this study was to evaluate the incidence of first thrombotic event (deep venous thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI), stroke or transient ischaemic attack (TIA) in a nationwide antiphospholipid antibody (aPL) carrier cohort. (nih.gov)
  • The antiphospholipid (anticardiolipin) syndrome (APS) is characterized by recurrent venous or arterial thrombosis (clots), recurrent fetal loss, and thrombocytopenia (a reduction in the number of platelets). (healthcentral.com)
  • Such antibodies are often found in association with pathological conditions, including thrombosis (clotting), fetal loss, and thrombocytopenia (low platelets). (healthcentral.com)
  • Some studies have shown that patients with increased levels of these types of antibodies have a greater risk of thrombosis (blood clot formation), recurrent fetal loss, thrombocytopenia (decreases in blood platelets), hemolytic anemia (decrease in red blood cells), and neurological disorders. (readabstracts.com)
  • objective: To measure the accuracy of anticardiolipin antibodies (aCL) in identifying a history of thrombosis among patients with systemic lupus erythematosus (SLE) or the primary antiphospholipid syndrome (PAPS). (uthscsa.edu)
  • Nevertheless, the negativity to classic aPL criteria does not imply that other antibodies may be present or involved in the onset of thrombosis. (haematologica.org)
  • The 14th International Congress on Antiphospholipid Antibodies Task Force criteria for identifying APS requires testing for cardiolipin antibodies, lupus anticoagulant, and beta-2 glycoprotein antibodies when one of two clinical problems exist, blood clots (thrombosis) or pregnancy morbidity. (labcorp.com)
  • Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome, idiopathic spontaneous abortion, and systemic lupus erythematosus (SLE). (wikipedia.org)
  • This is in contrast to rheumatoid arthritis with systemic sclerosis (scleroderma) because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. (wikipedia.org)
  • Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In autoimmune disease, ACA are beta-2 glycoprotein dependent In syphilis, ACA are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease. (wikipedia.org)
  • Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with infectious mononucleosis and postulated the existence of cross-reactions between infectious (viral) antigens and cardiolipin. (annals.org)
  • The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. (bmj.com)
  • Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles were studied for their effects on lymphocytes and neutrophils. (bmj.com)
  • Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL)-coated latex beads mixed together with beta 2-GPI but were unaffected by addition of excess beta 2-GPI, CL micelles, or CL-coated latex beads alone. (rupress.org)
  • LS-F41209 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Porcine Anti-Cardiolipin antibody (IgM). (lsbio.com)
  • It is based upon a Custom assay principle and can be used to detect levels of Anti-Cardiolipin antibody (IgM) as low as 0.225 nanograms per millilter. (lsbio.com)
  • Serum anti-GQ1b antibodies and IgM anti-cardiolipin antibody were positive. (alliedacademies.org)
  • Our case suggests that MFS presenting with proptosis and pain may be associated with serum anti-GQ1b antibodies and IgM anti-cardiolipin antibody. (alliedacademies.org)
  • Anti-cardiolipin antibodies are implicated in the pathogenesis of thrombotic diseases and systemic lupus erythematosus (SLE) [ 3 ]. (alliedacademies.org)
  • described a Japanese MFS patient with low titer of serum anti-GQ1b antibodies and increased IgG anti-cardiolipin antibody [ 6 ]. (alliedacademies.org)
  • Results: Mean level of anti cardiolipin antibody (ACLA) in patients and control groups were 0.192±0.11 and 0.087±0.200 optical density (OD) respectively. (ac.ir)
  • What is Anti-Cardiolipin Antibody (ACA)? (fertilitysmarts.com)
  • Definition - What does Anti-Cardiolipin Antibody (ACA) mean? (fertilitysmarts.com)
  • Anti-cardiolipin antibody (ACA) is a type of antiphospholipid antibody (a blood protein) directed against the fat-like component of the mitochondrial cell membrane called cardiolipin. (fertilitysmarts.com)
  • Anti-cardiolipin antibody testing and reporting practices among laboratories participating in a large external Quality Assurance Program. (lww.com)
  • In particular, the disease is characterised by antibodies against cardiolipin ( anti-cardiolipin antibodies ) and β 2 glycoprotein I . (thefullwiki.org)
  • Antiphospholipid syndrome is tested for in the laboratory using both liquid phase coagulation assays ( lupus anticoagulant ) and solid phase ELISA assays ( anti-cardiolipin antibodies ). (thefullwiki.org)
  • The testing of antibodies to the possible individual targets of aPL such as β 2 Glycoprotein 1 and antiphosphatidyl serine is currently under debate as testing for anticardiolipin appears to be currently sensitive and specific for diagnosis of APS even though cardiolipin is not considered an in vivo target for antiphospholipid antibodies. (thefullwiki.org)
  • Alterations in the level of anticoagulant proteins, disturbances of endothelial cell function, and the presence of cardiolipin antibodies and Factor V Leiden mutation may increase the cumulative thrombotic risk in MPD besides the risk imposed by platelet activation. (cdc.gov)
  • Objective To explore the relationship between serum anti - cardiolipin antibodies ( ACA ) and recurrent cerebral infarction ( RCI),and to provide the clinical evidence for the prevention and treatment of RCI. (bvsalud.org)
  • However, older patients had a higher incidence of antibodies against cardiolipin, a fat that is present in the membranes surrounding cells. (readabstracts.com)
  • Anticardiolipin antibodies (aCL) are specialized proteins that specifically bind and inactivate the phosphate-containing compound cardiolipin. (readabstracts.com)
  • Cardiolipin antibodies (IgG, IgM, and sometimes IgA) are frequently ordered since they are the most common antiphospholipid antibodies. (labcorp.com)
  • Anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) have been detected in patients with hepatitis C virus (HCV) infection and have been associated in autoimmune diseases (i.e. systemic lupus erythematosus) with an increased risk of thromboembolic events. (nih.gov)
  • The appearance of anticardiolipin antibodies (aCL) in patients with systemic lupus erythematosus (SLE) and other collagen diseases is associated with variety of clinical features, including arterial and venous thromboembolic manifestation, recurrent fetal loss and thrombocytopenia. (nii.ac.jp)
  • T Koike: 'Antibodies to β_2-glycoprotein I and clinical manifestaton in patients with systemic lupus erythematousus. (nii.ac.jp)
  • Anticardiolipin antibodies (aCL) are found in sera of patients with systemic lupus erythematosus (SLE) and related connective tissue diseades. (nii.ac.jp)
  • A previous study showed a reduction in antiphospholipid antibodies among patients with systemic lupus erythematosus who received belimumab. (rheumatologyadvisor.com)
  • This post-hoc analysis evaluated the effect of belimumab 10 mg/kg vs placebo on antiphospholipid antibodies (aPL) titers in patients with systemic lupus erythematosus (SLE). (rheumatologyadvisor.com)
  • Chatzidionysiou K, Samoli E, Sfikakis PP, Tektonidou MG. Effect of belimumab treatment on antiphospholipid antibodies levels: post-hoc analysis based on two randomised placebo-controlled trials in systemic lupus erythematosus [published online November 11, 2019]. (rheumatologyadvisor.com)
  • McHugh, NJ & Maddison, PJ 1989, ' HLA-DR antigens and anticardiolipin antibodies in patients with systemic lupus erythematosus ', Arthritis & Rheumatism , vol. 32, no. 12, pp. 1623-1624. (bath.ac.uk)
  • Antibodies against PLs have been commonly found in patients with autoimmune diseases such as systemic lupus erythematosus and primary antiphospholipid syndrome, in which clinical manifestations (mainly thrombotic events) have been directly attributed to antibodies against PLs. (cdc.gov)
  • Reticulate and stellate acral pigmentation associated with systemic lupus erythematosus and high titers of circulating anticardiolipin antibodies: a possible association with acral microlivedo. (elsevier.com)
  • A Hispanic man with a twenty-eight year history of systemic lupus erythematosus (SLE) and a high titer of anticardiolipin IgG antibodies was noted to have reticulate and stellate acral pigmentation. (elsevier.com)
  • HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. (cdc.gov)
  • Our objective was to determine the HLA-DPB1 allele associations of anticardiolipin (aCL) and anti-beta2GPI (a(beta)2GPI) antibodies, and of clinical manifestations of the antiphospholipid syndrome (APS), in systemic lupus erythematosus (SLE). (cdc.gov)
  • Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombotic manifestations and/or pregnancy-related complications in patients with persistently high antiphospholipid antibodies (aPL), the most common being represented by anticardiolipin antibodies (aCL), anti-beta 2 glycoprotein-I (aβ2GPI), and lupus anticoagulant (LAC). (haematologica.org)
  • 3 This definition was derived from clinical observation of recurrent miscarriages, central nervous system disease, and recurrent venous thromboembolism (VTE) in patients with systemic lupus erythematosus (SLE) and serum positivity for anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). (haematologica.org)
  • The presence of serum anticardiolipin (aCL) antibody without clinical symptoms does not support a diagnosis of antiphospholipid syndrome (APS). (medscape.com)
  • This test measures the level of IgA, IgG, IgM anticardiolipin antibodies in human serum or plasma. (personalabs.com)
  • In this study anticardiolipin antibodies (immunoglobulin G [IgG] isotype) were determined in serum from 100 patients with chronic hepatitis C and 52 healthy controls. (cun.es)
  • Here we report the first Chinese patient with MFS who showed proptosis and pain and had serum anti-GQ1b antibodies and IgM anticardiolipin antibody. (alliedacademies.org)
  • Miller Fisher syndrome (MFS) is a variant of Guillain-Barre syndrome (GBS) characterized by acute onset of ophthalmoplegia, ataxia and areflexia, and positive serum anti- GQ1b antibodies. (alliedacademies.org)
  • Persistent elevation of IgG anticardiolipin antibodies (aCL) was found in his serum and may be a marker of endothelial damage associated with either VWF or the patient's coincidental valvular heart disease. (bath.ac.uk)
  • An antibody found in the serum of patients with rheumatoid arthritis but not in those with other joint or soft tissue diseases. (thefreedictionary.com)
  • An antibody that cross-reacts with smooth muscle collagen and the gluten in wheat, found in the serum of people with celiac sprue and some related autoimmune diseases. (thefreedictionary.com)
  • An antibody formed against the chemical components of nerves, found in the serum of those with Guillain-Barré syndrome. (thefreedictionary.com)
  • An antibody formed against the gluten in wheat, found in the serum of people with celiac sprue. (thefreedictionary.com)
  • One 5ml non-anticoagulated serum sample for Anticardiolipin testing. (guysandstthomas.nhs.uk)
  • Anticardiolipin Antibodies and Immunoglobulin M and A in Graves' Disease', Iranian Journal of Medical Sciences , 30(1), pp. 6-9. (ac.ir)
  • Although belimumab did not show any significant effect over time on anticardiolipin (aCL) antibodies immunoglobulin G (IgG) or immunoglobulin M (IgM), the drug did have an effect on IgG and IgA in patients receiving concomitant antimalarials, according to study results published in Annals of the Rheumatic Diseases . (rheumatologyadvisor.com)
  • There are three different types of ACA, including IgG, IgM, and IgA (Ig is the short form for immunoglobulin, which means antibody). (fertilitysmarts.com)
  • an immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that induced its synthesis. (thefreedictionary.com)
  • Anticardiolipin IgG and IgM antibodies were determined by a semiquantitative ELISA assay (Reads,USA). (bmj.com)
  • Epitopes described in False positive ELISA tests for anticardiolipin antibodies in sera from patients with repeated abortion, rheumatologic disorders and primary biliary cirrhosis: correlation with elevated polyclonal IgM and implications for patients with repeated abortion. (iedb.org)
  • ELISA is the test used to detect these antibodies, IgM and IgG isotypes. (medscape.com)
  • Measurement of Anticardiolipin Antibody Levels of anticardiolipin antibody were determined with use of an ELISA according to the modified method of Loizou et al. (healthdocbox.com)
  • In 11/61 leprosy sera increased levels of IgG antibodies against β 2 -GPI were found by ELISA. (elsevier.com)
  • Leprosy anti-β 2 -GPI antibodies appear to be a separate antibody population recognizing only β 2 -GPI adsorbed on the ELISA plate. (elsevier.com)
  • aCL and a(beta)2GPI antibodies were measured by ELISA. (cdc.gov)
  • The present study sought to determine whether the level of anticardiolipin antibodies in women with recurrent abortion differed from that in the general population. (who.int)
  • The data cited by Dr. Anand [1] suggest that when treatment is warranted, warfarin may be more effective than aspirin in preventing recurrent thrombotic events in patients with elevated antiphospholipid antibody levels. (annals.org)
  • Among these, the presence of IgM ACA more strongly predicts the occurrence of recurrent miscarriages and is a better indicator of pregnancy outcome than other types of antibodies. (fertilitysmarts.com)
  • PROBLEM: Anticardiolipin antibodies (aCL) are commonly associated with recurrent pregnancy loss, though the mechanism is uncertain. (elsevier.com)
  • Anticardiolipin Antibody test is done for multiple reasons, but primarily for detection of blood clots and autoimmune diseases such as rheumatoid arthritis, lupus and also recurrent miscarriages. (1mg.com)
  • These antibodies increase the risk of developing recurrent inappropriate blood clots in both veins and arteries. (labtestsonline.org)
  • Patient(s): with recurrent fetal miscarriage who were positive for anticardiolipin antibody and normal fertile women. (healthdocbox.com)
  • These include recurrent fetal miscarriage, intrauterine fetal growth retardation, and preeclampsia, in connection with positivity for antiphospholipid antibodies. (healthdocbox.com)
  • It is also possible that HLA antigen systems are associated with recurrent fetal miscarriage in patients who are positive for antiphospholipid antibodies. (healthdocbox.com)
  • Several reports based on serologic HLA typing have pointed out the positive association between patients with recurrent fetal miscarriage who are positive for antiphospholipid antibodies and specific HLA alleles (13, 14). (healthdocbox.com)
  • Antiphospholipid antibodies are also associated with low platelet counts ( thrombocytopenia ) and with the risk of recurrent miscarriages (especially in the second and third trimester), premature labor, and pre-eclampsia . (labtestsonline.org)
  • We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among those patients who had active P. carinii pneumonia (2). (annals.org)
  • Antiphospholipid syndrome is an autoimmune disease , in which "antiphospholipid antibodies" (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes . (wikipedia.org)
  • Antiphospholipid (APL) antibodies are group of antibodies directed against epitopes on plasma proteins that are uncovered by binding of these proteins to anionic phospholipids on plasma membranes. (medscape.com)
  • Antiphospholipid syndrome (APS) is a condition in which antibodies that normally function to protect us from offending agents, start attacking the body's own tissues - phospholipids in this case. (fertilitysmarts.com)
  • In these patients, antibodies against PLs are specific for a neoepitope constituted by the union of β 2 GPI, a lipid-binding coagulation inhibitor, to the cellular membrane phospholipids ( 2 ). (cdc.gov)
  • Antiphospholipid antibody (aPL) is an antibody that reacts with negatively charged phospholipids, molecules which are common constituents of cell membranes. (healthcentral.com)
  • Antiphospholipid antibodies are a group of immune proteins ( antibodies ) that the body mistakenly produces against itself in an autoimmune response to phospholipids. (labtestsonline.org)
  • People with antibodies to phospholipids (aPL) may have a very high risk of forming blood clots. (umm.edu)
  • In this condition, your body makes antibodies that attack a kind of fat (phospholipids) in cells. (ahealthyme.com)
  • Patients with selective IgA deficiency also showed a high prevalence of this autoantibody (32%), while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. (bmj.com)
  • Antiphospholipid antibodies are a type of autoantibodies that have been implicated in the occurrence of thrombocytopenia and thrombotic events and have been described in autoimmune disorders and diverse viral diseases. (cun.es)
  • Autoantibodies called antinuclear antibodies (ANA) are detectable in most, although not all, patients with SLE. (adam.com)
  • Particular autoantibodies are associated with SLE, but the older group less frequently developed antibodies against DNA (the body's genetic molecules) as well as another antibody known as anti-Ro. (readabstracts.com)
  • Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. (wikipedia.org)
  • Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. (rupress.org)
  • Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly bind to beta 2-glycoprotein I (beta 2-GPI), which is adsorbed to an oxidized polystyrene surface. (rupress.org)
  • T Koike: 'Human β_2-glycoprotein I as an anticardiolipin cofactor determined using delated mutants expressed by a basculovirus system. (nii.ac.jp)
  • Sieven A.Krihs: 'Epitope specificity of monoclonal anti-β_2-glycoprotein I antibodies derived from patients with the antiphospholipid syndrome. (nii.ac.jp)
  • G.R.V.Hughes: 'β_2-glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. (nii.ac.jp)
  • Anticardiolipin antibodies and β_2-glycoprotein I.' Clin Immunol Immunopathol. (nii.ac.jp)
  • Publications] Igarashi.M., E.Matsuura, H.Nagae, K.Ichikawa, D.A.Triplett, T.Koike: 'Human beta2-glycoprotein I as an anticardiolipin cofactor determined using delated mutants expressed by a basculovirus system. (nii.ac.jp)
  • Publications] Min-Xia Wang.D.A.Kandiah, K.Ichikawa, M.Khamashta, G.Hughes, T.Koike, R.Roubey, Steven A.Krilis: 'Epitope specificity of monoclonal anti-beta2-glycoprotein I antibodies derived from pstients with the antiphospholipid syndrome. (nii.ac.jp)
  • Publications] Igarashi,M.,et al: 'Expression of anticardiolipin cofactor,human β_2-glycoprotein I,by a recombinant baculovirus/insect cell system. (nii.ac.jp)
  • Publications] Matsuura,E.,et al: 'Molecular definition of human β_2-glycoprotein I(β_2-GPI)by cDNA cloning and inter-species differences of β_2-GPI in alternation of anticardiolipin binding. (nii.ac.jp)
  • Publications] Koike, T., Matuura, E.: 'Anticardiolipin antibody and beta2-glycoprotein I : in Intractable Vasculitis Syndromes. (nii.ac.jp)
  • The most commonly used tests to detect APL include lupus anticoagulant (LAC), anticardiolipin (ACL) antibodies, and anti-β 2 -glycoprotein I antibodies. (medscape.com)
  • Per antiphospholipid syndrome diagnostic criteria, these anti-β 2 -glycoprotein I antibodies of IgG and/or IgM isotype should be present in the in plasma, in a titer greater than the 99th percentile to be considered a positive test result. (medscape.com)
  • Fingerprint Dive into the research topics of 'Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I'. Together they form a unique fingerprint. (elsevier.com)
  • Anticardiolipin antibody (ACA) includes beta2-glycoprotein I-dependent (β2-GPI-dependent) and β2-GPI-independent forms. (ovid.com)
  • Anticardiolipin (aCL), anti-β 2 -glycoprotein I (anti-β 2 -GPI), anti-prothrombin (aPT) and anti-annexin V (aANXV) antibodies are anti-phospholipid antibodies (aPL) with different antigenic and diagnostic specificities. (biomedcentral.com)
  • The most frequently detectable aPL are anticardiolipin antibodies (aCL), antiβ2-glycoprotein I antibodies (anti-β2-GPI), and lupus anticoagulant (LAC). (haematologica.org)
  • Beta-2 glycoprotein 1 testing may be ordered along with the other antiphospholipid antibodies to detect their presence and to provide the healthcare practitioner with additional information. (labcorp.com)
  • I've tested positive for anticardiolipin antibodies. (healthtap.com)
  • Four out of 20 patients (20%) were positive for anticardiolipin antibodies. (elsevier.com)
  • BACKGROUND AND PURPOSE: The association between anticardiolipin antibody (aCL) and ischemic stroke is controversial, and there are few case-control studies of Asian populations. (elsevier.com)
  • This was done to clarify the role of the HLA class II antigens in patients positive for anticardiolipin antibody who repeatedly have fetal miscarriages. (healthdocbox.com)
  • Antiphospholipid syndrome (APS) , also called Hughes syndrome, is a recognized group of signs and symptoms that includes the formation of blood clots, miscarriages, platelet deficiency (thrombocytopenia), and the presence of one or more antiphospholipid antibodies. (labtestsonline.org)
  • We studied the effect of β 2 -GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). (elsevier.com)
  • Moreover, the assays to measure the levels of these antibodies have not yet been standardized. (haematologica.org)
  • Neither ACA nor LA were associated with antinuclear antibodies (ANA) or rheumatoid factor (Rh factor). (nih.gov)
  • This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves' disease. (ac.ir)
  • Patients and methods: Anticardiolipin and rheumatoid factor were measured in sera of 84 patients (29 male, 55 female) with evidence of Graves' disease and 41 healthy individuals (15 male, 26 female) with negative history of hyperthyroidism and other autoimmune diseases. (ac.ir)
  • Antinuclear antibodies also occur in patients with rheumatoid arthritis, Sjögren's syndrome, and scleroderma. (thefreedictionary.com)
  • IgG and IgM anticardiolipin antibodies following treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis. (duke.edu)
  • OBJECTIVE: To assess the occurrence of anticardiolipin antibodies (aCL) in patients with early rheumatoid arthritis (RA) receiving treatment with infliximab plus methotrexate (MTX) versus MTX alone. (duke.edu)
  • [5] Some studies have shown the presence of antiphospholipid antibodies in the blood and spinal fluid of patients with psychological symptoms. (wikipedia.org)
  • In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE. (cdc.gov)
  • Despite three decades of research, the pathophysiological basis of the association between clinical disease and antiphospholipid antibodies (aPL) remains uncertain. (ispub.com)
  • That aPL are associated with clinical disease in non-autoimmune patients supports the notion that the antibodies are pathogenic ( 1 ). (ispub.com)
  • This research is in continuous development as the clinical relevance of these antibodies is far from being completely clarified. (haematologica.org)
  • In this review, we will discuss criteria for defining the SN-APS, the new potential non-criteria antibodies implied in SN-APS and its clinical management. (haematologica.org)
  • Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortion. (wikipedia.org)
  • A doctor will base an SLE diagnosis on certain specific criteria including symptom history and the results of blood tests for antinuclear antibodies. (adam.com)
  • Reticulate and stellate acral pigmentation should be considered a possible manifestation of SLE and high titers of anticardiolipin antibodies, or a consequence of therapy. (elsevier.com)
  • The overall prevalence of antibodies gradually increased with age, reaching 23.7% in the age group 35-45 years. (who.int)
  • The prevalence of anti-β 2 -GPI and aANXV antibodies did not differ between patient groups. (biomedcentral.com)
  • The prevalence of antiphospholipid antibodies (aPL) in the general population is difficult to estimate due to the lack of population-based studies. (haematologica.org)
  • Low levels of antiphospholipid antibodies may be associated with HIV , Lyme disease , and some cancers. (labtestsonline.org)
  • Enzyme-linked immunosorbent assay was used for detection of anticardiolipin antibodies in a group of 26 patients defined as habitual aborters [‎at least three consecutive spontaneous abortions]‎, and in a control group of 26 patients each of whom had had at least one live birth without pregnancy wastage. (who.int)
  • The presence of antiphospholipid antibodies (aPL) in the absence of blood clots or pregnancy-related complications does not indicate APS (see below for the diagnosis of APS). (wikipedia.org)
  • Yesterday I lost another pregnancy of multiples to antiphospholipid antibody syndrome. (dailystrength.org)
  • Anticardiolipin Antibodies and Pregnancy . (healthcentral.com)
  • In patients with no evidence of liver disease and a history of thrombotic events, hepatitis C markers were absent in all cases who tested negatively for anticardiolipin antibodies (n = 37), but were present in 16.7% of those positive for anticardiolipin (n = 36) (P = .01). (cun.es)
  • Occult HCV infection is present in a significant proportion of patients with thrombotic disorders and positive for anticardiolipin (the antiphospholipid syndrome). (cun.es)
  • Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective study. (nih.gov)
  • 1 patient had posi- non-central nervous system thrombotic events (e.g., tive antiphospholipid antibodies. (cdc.gov)
  • In kidney transplant recipients, anticardiolipin (ACL) antibodies without antiphospholipid syndrome (APS) are found in up to 38% of patients and could be associated with thrombotic events (TEs). (cepia.team)
  • cytotoxic antibody any specific antibody directed against cellular antigens, which when bound to the antigen, activates the complement pathway or activates killer cells, resulting in cell lysis. (thefreedictionary.com)
  • Antibodies neutralize or destroy antigens in several ways. (thefreedictionary.com)
  • In a normal immune system, the body produces proteins (antibodies) to fight viruses, toxins and other potentially harmful foreign substances (antigens). (adam.com)
  • The incidence and significance of IgG and IgM anticardiolipin in antibodies (aCLa) in patients with acute rheumatic fever (ARF), chronic rheumatic heart disease (CRHD) and streptococcal pharyngitis have been investigated in order to determine whether these antibodies play an important role in the pathogenesis and if they are markers that can be used to confirm disease activity. (ege.edu.tr)
  • Antiphospholipid syndrome (APS) is an autoimmune disorder , meaning that the body's immune system makes proteins known as antibodies that mistakenly attack its own cells or tissues. (labtestsonline.org)
  • But in APS, antibodies attack the lipid-proteins found in the outermost layer of cells (cell membranes) and platelets. (labtestsonline.org)
  • antibodies against β 2 GPI were undetectable, and only IgG anticardiolipin was still detected at lower titers (+33). (cdc.gov)
  • The presence of lupus anticoagulants and anticardiolipin antibodies (aCL) has been associated with young victims of myocardial infarction (heart attack). (healthcentral.com)
  • Lupus anticoagulants are antibodies against substances in the lining of cells. (umm.edu)
  • Background Anticardiolipin antibodies (aCL) have been associated with an increased risk of stroke and thrombo-occlusive events. (ahajournals.org)
  • Background Anticardiolipin antibodies (ACL-Ab) are associated with various neurologic syndromes, but idiopathic intracranial hypertension (IIH) has only rarely been reported in this context. (jamanetwork.com)
  • The patient on initial screening will typically have been found to have a prolonged APTT that does not correct in an 80:20 mixture with normal human plasma (50:50 mixes with normal plasma are insensitive to all but the highest antibody levels). (thefullwiki.org)
  • Dr. Hess lists several potential reasons why we were not able to detect an association between anticardiolipin antibodies and risk for ischemic stroke. (annals.org)
  • Although an association between anticardiolipin antibodies and ischemic stroke cannot be ruled out, as we noted in our paper, the null findings are consistent with another prospective study among survivors of acute myocardial infarction [2] . (annals.org)
  • SLE is one of the autoimmune diseases in which antibodies are inappropriately made against the body's own molecules. (readabstracts.com)
  • Pregnant patients who have anticardiolipin antibodies are at increased risk for miscarriage, fetal growth retardation and stillbirth. (healthcentral.com)
  • Publications] Matsuura,E.,et al: 'Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. (nii.ac.jp)
  • The antiphospholipid syndrome is characterised by arterial and venous thromboses affecting small and large vessels, together with the presence of lupus anticoagulant and anticardiolipin antibodies. (nih.gov)
  • Anticardiolipin antibodies are the result of an autoimmune disorder where your body makes antibodies against its own tissues. (medhelp.org)
  • Due to a lack of sustainable in vitro culture techniques for T. pallidum , unavailability of Food and Drug Administration (FDA)-cleared molecular tests and limitations associated with direct detection tests such as dark field microscopy, indirect serological tests that detect non-treponemal and treponemal antibodies remain the mainstay for routine syphilis detection. (bmj.com)
  • In order to improve APS diagnosis, several new approaches in aPL detection have recently been suggested, such as multiline immunodot assay, detection of aPL by flow cytometry using beads with particular surface properties, and the newly developed automated BioPlex system technology for parallel detection of aCL and anti-β2GPI antibodies of IgG, IgA, and IgM isotypes. (intechopen.com)
  • After a complete medical history including your family history and a physical examination, your physician will order blood tests that can detect antiphospholipid antibodies, including lupus anticoagulant and anticardiolipin antibodies. (healthcentral.com)
  • We have evaluated the risk factors for arterial and venous thromboses in a wide variety of renal patients with both glomerular and non‐glomerular diseases, including the presence of nephrotic syndrome, inborn and acquired coagulation defects (i.e., factor V Leiden, MTHFR gene mutation, 20210 prothrombin gene mutation, and antiphospholipid antibodies), corticosteroid treatment, and dyslipidemia. (intechopen.com)
  • The quantitative measurement of anticardiolipin (aCL) antibody is important in diagnosing antiphospholipid syndrome (APS). (medscape.com)
  • Twenty patients with eclampsia were studied for the presence of anticardiolipin antibodies by the standard microflocculation test (quantitative) used in the VDRL. (elsevier.com)