Antibodies, Anticardiolipin
Antiphospholipid antibodies found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. The antibodies are detected by solid-phase IMMUNOASSAY employing the purified phospholipid antigen CARDIOLIPIN.
Cardiolipins
Acidic phospholipids composed of two molecules of phosphatidic acid covalently linked to a molecule of glycerol. They occur primarily in mitochondrial inner membranes and in bacterial plasma membranes. They are the main antigenic components of the Wassermann-type antigen that is used in nontreponemal SYPHILIS SERODIAGNOSIS.
Antiphospholipid Syndrome
The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).
Lupus Coagulation Inhibitor
An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
beta 2-Glycoprotein I
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Antibodies, Antiphospholipid
Antibodies
Antibody Specificity
Autoantibodies
Lupus Erythematosus, Systemic
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Immunoglobulin M
Immunoglobulin G
Antibodies, Antinuclear
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Glycoproteins
Antibody Formation
Antibodies, Neutralizing
Blood Coagulation Factors
Thrombophilia
Immunoglobulin Isotypes
Antibody Affinity
A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Prothrombin
Cross Reactions
Antibodies, Anti-Idiotypic
Lupus Vasculitis, Central Nervous System
Binding Sites, Antibody
Immunoglobulin A
Pregnancy
Partial Thromboplastin Time
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
Activated Protein C Resistance
Protein S Deficiency
An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Pregnancy Complications, Hematologic
Antibodies, Neoplasm
Leg Ulcer
Antigen-Antibody Complex
Calciphylaxis
Abortion, Spontaneous
Autoimmune Diseases
Pregnancy Complications
Immunoglobulin Idiotypes
Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.
Protein C
Prospective Studies
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Immunization, Passive
Neutralization Tests
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Prednisolone
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Immunosorbent Techniques
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Antigen-Antibody Reactions
Antibodies, Bispecific
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Single-Chain Antibodies
Antibodies, Blocking
Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)
Factor V
Amino Acid Sequence
Behcet Syndrome
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Lupus Nephritis
Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
Immunoglobulin Fab Fragments
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Risk Factors
Antibodies, Heterophile
Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.
Antibodies, Catalytic
Phosphatidylserines
Cerebrovascular Disorders
Cerebral Infarction
The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
Antibodies against phospholipids and oxidized LDL in alcoholic patients. (1/381)
Antiphospholipid antibodies (APA) are a generic term describing antibodies that recognize various phospholipids. Hepatocyte damage is a cardinal event in the course of alcoholic liver injury and autoantibodies against phospholipids could play an important role in this process. APA in alcoholic patients seem to reflect membrane lesions, impairment of immunological reactivity, liver disease progression and they correlate significantly with disease severity. LDL oxidation is supposed to be one of the most important pathogenic mechanisms of atherosclerosis and antibodies against oxidized low-density lipoprotein (oxLDL) are some kind of an epiphenomenon of this process. The scope of our study was to determine some autoantibodies (IgG-oxLDL and antiphospholipid antibodies) and their possible changes in alcoholic patients. We studied IgG-oxLDL and four APA - anticardiolipin antibodies (ACA), antiphosphatidylserine antibodies (APSA) antiphosphatidylethanolamine antibodies (APE) and antiphosphatidylcholine antibodies (APCA) in 35 alcoholic patients with mildly affected liver function at the beginning of the abuse treatment. The control group consisted of 60 healthy blood donors. In the studied group, we obtained positive results concerning total ACA in 17.1 % of alcoholic patients (8.3 % in the control group), 11.4 % IgG-ACA (6.7 %), 8.6 % IgM-ACA (3.3 %), 14.3 % total APE (6.7 %), 14.3 % total APCA (8.3 %) and 20 % total APSA (8.3 % in the control group). The IgG-oxLDL (406.4+/-52.5 vs 499.9+/-52.5 mU/ml) was not affected in alcoholic patients. We conclude that the autoantibodies against oxLDL are present in sera of alcoholics and healthy blood donors. Based on our results which revealed a wide range of IgG-oxLDL titres in the healthy population, this parameter does not appear to be very promising for the evaluation of the risk of atherosclerosis. Alcoholics with only mild affection of liver functions did not exhibit a significantly higher prevalence of all studied antiphospholipid antibodies (ACA, APSA, APE, APCA) which could lead to membrane lesions in these patients. (+info)Cerebral vasculopathy in HIV infection revealed by transcranial Doppler: A pilot study. (2/381)
BACKGROUND AND PURPOSE: There is growing evidence for affection of cerebral vessels during human immunodeficiency virus (HIV) infection. We prospectively evaluated cerebrovascular reserve capacity (CRC) in HIV-seropositive patients by transcranial Doppler sonography (TCD) after systemic administration of acetazolamide. We hypothesized that a disturbed vasoreactivity would reflect the cerebral arteries' involvement in HIV infection. METHODS: We assessed the mean blood flow velocity (BFV) of the middle cerebral artery and its increase after intravenous administration of 1 g acetazolamide (CRC) in 31 HIV-infected individuals without symptoms of cerebrovascular disease (mean+/-SD age, 39+/-11 years). Stenotic or occlusive lesions of the large brain-supplying arteries were excluded by color-coded duplex and transcranial imaging. BFV and CRC were also measured in an age-matched group of 10 healthy control subjects. Patients were classified according to clinical, laboratory, and neurophysiological parameters. We also performed cerebral MRI (n=25) and rheumatological blood tests (n=26). RESULTS: Baseline BFV and CRC both were significantly reduced in HIV-infected patients as compared with control subjects (P<0.05, Student's t test). These findings did not correlate with duration of seropositivity, helper cell count, or other clinical, rheumatological, and neuroradiological findings. CONCLUSIONS: Our findings support the hypothesis of a cerebral vasculopathy etiologically associated with HIV infection. (+info)Anti-phospholipid antibodies and CD5+ B cells in HIV infection. (3/381)
This cross-sectional study evaluates the correlation between anti-phospholipid antibodies and CD5+ B cells in 110 patients infected with HIV-1. There were 89.1% of the patients who had IgG antibodies against cardiolipin and phosphatidylserine. The prevalence of IgM and IgA antibodies was < 22%. AIDS was associated with lower frequencies of IgM antibodies against cardiolipin (P = 0.05) and IgG-antibodies against cardiolipin and phosphatidylserine (P = 0.011). Drug users had higher IgM antibodies against phospholipids than patients from other risk groups (P = 0.02). A history of thromboembolic events was not accompanied by higher levels of anti-phospholipid antibodies (P > 0.2). No correlation between anti-phospholipid antibodies and CD5+ B cells was detected. Percentage part of CD5+ B lymphocytes was elevated in all patients and absolute CD4+ T lymphocyte counts and HIV p24 antigen were inversely correlated. In advanced disease a significant reduction of anti-phospholipid antibodies was contrasted with persistent elevation of CD5+ B lymphocytes. These observations may reflect immunological dysfunction involving apoptosis and endothelial damage rather than polyclonal B cell hyperstimulation. A possible explanation would be that in HIV infection an increased rate of spontaneous apoptosis in peripheral blood lymphocytes is accompanied by functional and structural changes of mitochondria. Therefore, structurally altered mitochondrial phospholipids could serve as antigen to induce specific humoral immune responses. (+info)Antibodies to adult human endothelial cells cross-react with oxidized low-density lipoprotein and beta 2-glycoprotein I (beta 2-GPI) in systemic lupus erythematosus. (4/381)
Cardiovascular manifestations are common in systemic lupus erythematosus (SLE). Oxidized low-density lipoprotein (oxLDL) is implicated in cardiovascular disease, especially atherosclerosis, and cross-reacts with antibodies to cardiolipin (aCL). beta 2-GPI is a plasma protein participating in the coagulating cascade, and is also cofactor for aCL, and some aCL have been shown to be directed against beta 2-GPI and/or complexes between beta 2-GPI and phospholipids. Lysophosphatidylcholine (LPC) is a phospholipid present both in oxLDL and in damaged endothelium, and we recently showed that LPC is involved in the antigenicity of oxLDL. Antibodies to endothelial cells (aEC) correlate with diseases activity in SLE and vasculitis, and we recently showed that aEC are enhanced in cardiovascular disease such as borderline hypertension and early atherosclerosis. aEC were determined using EC from adult V. Saphena Magna. Antibody levels were determined by ELISA. aEC of IgG type were enhanced in 184 patients with SLE compared with 85 healthy controls. There was a close correlation between aoxLDL, aCL, aLPC, a beta 2-GPI and aEC. Binding of sera to EC was competitively inhibited by beta 2-GPI, LPC and oxLDL. Taken together, the data indicate that EC share antigenic epitopes with beta 2-GPI and with oxLDL, especially LPC. Phospholipids in EC membranes may thus be antigenic epitopes. beta 2-GPI may bind to these phospholipids, and become an autoantigen. LPC is formed by oxidation of phospholipids and/or proinflammatory factors leading to activation of phospholipase A2, and the findings indicate the potential role of both lipid oxidation and phospholipase A2 in SLE. (+info)Conformationally altered beta 2-glycoprotein I is the antigen for anti-cardiolipin autoantibodies. (5/381)
Anti-cardiolipin autoantibodies (aCL) induce thrombosis and recurrent fetal death. These antibodies require a 'cofactor', identified as beta 2-glycoprotein I (beta 2-GPI), to bind phospholipids. We show here that aCL can bind beta 2-GPI in the absence of phospholipid. Binding of aCL to beta 2-GPI is dependent upon the beta 2-GPI being immobilized on an appropriate surface including cardiolipin, irradiated polystyrene and nitrocellulose membrane. This effect cannot be explained by increased antigen density of beta 2-GPI immobilized on these surfaces. Rather, conformational changes that occur following the interaction of beta 2-GPI with phospholipid render this protein antigenic to aCL. Liquid-phase beta 2-GPI was not antigenic for aCL. Thus, aCL cannot bind circulating beta 2-GPI. These findings may explain why patients with aCL can remain healthy for many years but then undergo episodes of thrombosis or fetal loss without changes in their circulating aCL profile, as the triggering event for these pathologies can be predicted to be one that renders beta 2-GPI antigenic for aCL. (+info)A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus. (6/381)
OBJECTIVE: To prospectively analyze the association between changes in cognitive function and circulating anticardiolipin antibodies (aCL) over a period of 5 years in patients with systemic lupus erythematosus (SLE). METHODS: Cognitive function was assessed in 51 unselected female SLE patients at baseline and after a mean followup of 64.5 months (range 52-71 months), using standardized tests of cognitive function, i.e., the Wechsler Adult Intelligence Scale-Revised, the Wechsler Memory Scale-Revised, and the California Verbal Learning Test. Circulating IgG, IgA, and IgM aCL and anti-double-stranded DNA (anti-dsDNA) antibody levels were determined by enzyme-linked immunosorbent assay on 4-7 occasions over the same time period. Persistent antibody reactivity was defined as levels more than 2 standard deviations (moderately positive) and more than 5 standard deviations (highly positive) above the mean for normal controls over the duration of the study. Changes in overall cognitive performance and in raw scores on individual cognitive tests were compared in patients who were persistently positive or negative for aCL. RESULTS: At baseline 11 patients (22%) were cognitively impaired, compared with 7 (14%) at followup. Between 16% and 37% of patients had persistently elevated aCL levels of different isotypes. There was no significant difference in the prevalence of overall cognitive impairment in patients who were persistently positive for aCL compared with those who were not. In contrast, over the period of study, patients who had persistent IgG aCL positivity had a reduction in psychomotor speed, and patients who had persistent IgA aCL positivity had a reduction in conceptual reasoning and executive ability. Similar associations with anti-dsDNA antibodies were not found. CONCLUSION: These results suggest that IgG and IgA aCL may be responsible for long-term subtle deterioration in cognitive function in patients with SLE. (+info)A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus. (7/381)
OBJECTIVE: To determine the relationship between persistently raised anticardiolipin antibody (aCL) levels and neuropsychological performance in patients with systemic lupus erythematosus (SLE). METHODS: Forty-five patients with SLE underwent a detailed neuropsychological assessment on 2 occasions 12-18 months apart. Serum samples stored since the time of previous assessments as well as samples obtained 6 months to 2 years before the first neuropsychological assessment were tested for IgG aCL levels. Patients were divided into 4 groups according to the number of times their aCL levels were elevated (never, once, twice, 3 times). A wide-ranging battery of new neuropsychological tests was utilized, and the results were compared with double-stranded DNA (dsDNA) antibody levels, C3 levels, and results of magnetic resonance imaging (MRI). RESULTS: Analysis of variance revealed that the group with persistently elevated aCL levels performed less well than the other groups. At the first neuropsychological assessment, poorer performance by this group was noted for letter cancellation (P = 0.02), trail making task B (P = 0.04), and digit span (P = 0.03). At the second assessment, letter cancellation (P = 0.01), trail making task A (P = 0.03), trail making task B (P = 0.01), word fluency (P = 0.01), and reaction time (P = 0.05) were impaired. In contrast, no significant differences in neuropsychological test results were identified with respect to DNA antibody or C3 levels. MRI abnormalities were associated with both persistent elevation of aCL levels and low C3 levels. CONCLUSION: Levels of IgG aCL that were persistently elevated over a 2-3-year period (as opposed to never or occasionally elevated) were associated with significantly poorer performance in cognitive function by patients with SLE. Tasks requiring speed of attention and concentration appear to be particularly affected. (+info)A possible role for activated protein C resistance in patients with first and second trimester pregnancy failure. (8/381)
Thrombophilia was recently suggested as a possible factor in recurrent pregnancy losses. We studied prospectively 125 patients (mean age 31.4 +/- 5.6 years) with one or more first or second trimester pregnancy losses for the prevalence of activated protein C resistance (APCR). Proteins C and S antigens, antithrombin III, anticardiolipin, and lupus anti-coagulant were also evaluated. Patients with uterine malformations, hormonal abnormalities, chromosomal translocations and infectious causes were excluded. A control group of 125 women with no past fetal loss were matched with the study group. Whenever the APC-sensitivity ratio (APC-SR) was +info)
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Anticardiolipin antibodies[edit]. Anti-cardiolipin antibodies can be detected using an enzyme-linked immunosorbent assay (ELISA ... since β2-glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a ... Antiphospholipid syndrome is an autoimmune disease, in which "antiphospholipid antibodies" (anticardiolipin antibodies and ... Patients with both Lupus anticoagulant antibodies and moderate/high titre anticardiolipin antibodies show a greater risk of ...
HLA-DR4
"HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with ... "HLA class II alleles associations of anticardiolipin antibodies". Lupus. 9 (1): 47-55. doi:10.1177/096120330000900109. PMID ... DRB1*04:02: drug-triggered/idiopathic pemphigus vulgaris, type 1 diabetes, SLE associated anti-cardiolipin and anti-β2 ... glycoprotein I. DRB1*04:03: polycystic ovary syndrome, SLE associated anti-cardiolipin and anti-β2 glycoprotein I. DRB1*04:04: ...
Livedo reticularis
... a rare manifestation of Graves hyperthyroidism associated with anticardiolipin antibodies". South. Med. J. 97 (6): 601-3. doi: ... or blood tests for antibodies associated with antiphospholipid syndrome or systemic lupus erythematosus. Other than identifying ... "Livedo Vasculopathy Associated with IgM Anti-phosphatidylserine-prothrombin Complex Antibody". Acta Dermato Venereologica. 90 ( ... sarcoidosis and Sjögren's syndrome Livedo vasculopathy associated with IgM antiphosphatidylserine-prothrombin complex antibody ...
STING-associated vasculopathy with onset in infancy
... and anticardiolipin antibodies.[citation needed] The erythrocyte sedimentation rate and C reactive protein levels tend to be ...
Takayasu's arteritis
Takayasu arteritis is not associated with ANCA, rheumatoid factor, ANA, and anticardiolipin antibodies. Most people with ...
Osteonecrosis of the jaw
... anticardiolipin antibodies, thrombophilia, and hypofibrinolysis". J Lab Clin Med. 127 (5): 481-8. doi:10.1016/S0022-2143(96) ...
Cerebritis
The two antibodies implicated are anticardiolipin and lupus anticoagulant. Anticardiolipin antibodies attach to the endothelial ... Anti-neuronal antibodies. The three identified anti-neuronal antibodies postulated in CNS involvement are the lympho-cytotoxic ... These antibodies also correlate with cognitive and visual spatial defects. Second, the anti-neuronal membrane antibodies are ... These antibodies are seen in 90% of SLE patients with psychosis. Antiphospholipid antibodies. ...
Venereal Disease Research Laboratory test
Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... It therefore detects anti-cardiolipin antibodies (IgG, IgM or IgA), visualized through foaming of the test tube fluid, or " ... The syphilis anti-cardiolipin antibodies are beta-2 glycoprotein independent, whereas those that occur in antiphospholipid ... "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but ...
Apolipoprotein H
Shi W, Chong BH, Hogg PJ, Chesterman CN (1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of ... Kumar KS, Jyothy A, Prakash MS, Rani HS, Reddy PP (2002). "Beta2-glycoprotein I dependent anticardiolipin antibodies and lupus ... systemic lupus erythematosus (SLE)). Positivity for anti-cardiolipin antibodies in diagnostic tests for autoimmune ... glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody ...
Cardiolipin
These antibodies are usually picked up in young women with recurrent spontaneous abortions. In anti-cardiolipin-mediated ... Patients with anti-cardiolipin antibodies (Antiphospholipid syndrome) can have recurrent thrombotic events even early in their ... Hokama Y, Campora CE, Hara C, Kuribayashi T, Le Huynh D, Yabusaki K. Anticardiolipin antibodies in the sera of patients with ... Anti-cardiolipin antibodies can also be increased in numerous other conditions, including systemic lupus erythematosus, malaria ...
Catastrophic antiphospholipid syndrome
An Enzyme-Linked ImmunoSorbent Assay (ELISA) test is done to detect anticardiolipin antibodies' presence in the blood. ... Positive test are often repeated due to the fact that antilipid antibodies can be present in the body for short stints due to ... The syndrome is caused by antiphospholipid antibodies that target a group of proteins in the body that are associated with ... These antibodies activate endothelial cells, platelets, and immune cells, ultimately causing a large inflammatory immune ...
Libman-Sacks endocarditis
In SLE, LSE has been linked to pericarditis, presence of anticardiolipin antibodies, arterial and venous thromboses, and ...
HLA-DR52
2000). "HLA class II alleles associations of anticardiolipin and antibeta2GPI antibodies in a large series of European patients ... acute necrotizing encephalopathy DRB3*0301 is weakly associated with anticardiolipin antibodies in SLE DRB3*0301:DRB1*1302 may ... "Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly ... serum IgG antibodies to Chlamydia pneumoniae with essential hypertension, ...
Systemic lupus erythematosus
Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis.[ ... Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE ... These antibodies clump into antibody-protein complexes which stick to surfaces and damage blood vessels in critical areas of ... Simplest classification tree: SLE is diagnosed if a person has an immunologic disorder (anti-DNA antibody, anti-Smith antibody ...
Lupus
Another autoantibody finding in SLE is the anti-cardiolipin antibody, which can cause a false positive test for syphilis.[ ... Subtypes of antinuclear antibodies include anti-Smith and anti-double stranded DNA (dsDNA) antibodies (which are linked to SLE ... and anti-histone antibodies (which are linked to drug-induced lupus). Anti-dsDNA antibodies are highly specific for SLE; they ... The anti-dsDNA antibody titers also tend to reflect disease activity, although not in all cases. Other ANA that may occur in ...
Lupus headache
... headaches in SLE and associated Raynaud's phenomenon and/or anti-cardiolipin antibodies. Further studies are needed however to ... Annese V, Tomietto P, Venturini P, D'Agostini S, Ferraccioli G (2006). "[Migraine in SLE: role of antiphospholipid antibodies ...
Mixed connective tissue disease
The presence of anticardiolipin antibodies is a more serious risk factor for the disease, as well as the presence of more ... Anti-RNP antibodies in elevated levels, especially antibodies against protein 68 kD. Absence of severe renal or CNS disease. ... SLE, scleroderma, and in MCTD have antibodies against anti-U1-snRNP at differing percentages. These antibodies are in most MCTD ... Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody. After the ...
Steven Krilis
"Identification of a region of β2-glycoprotein I critical for lipid binding and anti-cardiolipin antibody cofactor activity" ( ... "A phospholipid-beta 2-glycoprotein I complex is an antigen for anticardiolipin antibodies occurring in autoimmune disease but ... and a region recognized by anticardiolipin antibodies" (1994) Journal of Immunology, 152 (2), pp. 653-659. Cited 195 times. ... McNeil, H.P., Chesterman, C.N., Krilis, S.A. "Immunology and clinical importance of antiphospholipid antibodies" (1991) ...
Acute esophageal necrosis
Aortic dissection Anti-cardiolipin antibodies CMV infection Herpetic infection Hyperglycemia Hypersensitivity to broad-spectrum ...
Amaurosis fugax
... syndrome Polycythemia Hypercoagulability Protein C deficiency Antiphospholipid antibodies Anticardiolipin antibodies Lupus ... "Amaurosis fugax associated with antiphospholipid antibodies". Annals of Neurology. 25 (3): 228-32. doi:10.1002/ana.410250304. ...
Thrombophilia
... anti-cardiolipin antibodies, and anti-β2-glycoprotein 1 antibodies; it is therefore regarded as an autoimmune disease. In some ... The risk is determined by the subtype of antibody detected, by the antibody titer (amount of antibodies), whether multiple ... anti-cardiolipin antibody, anti-β2 glycoprotein 1 antibody, activated protein C resistance, fibrinogen tests, factor V Leiden ... Recurrent miscarriage is an indication for thrombophilia screening, particularly antiphospholipid antibodies (anti-cardiolipin ...
ACLA
... is an acronym that may refer to: Anti-cardiolipin antibodies Allegheny County Library Association, a library association ...
ACA
... acid Advisory Committee for Aeronautics Anterior cerebral artery Anti-cardiolipin antibodies Anti-centromere antibodies ...
Dilute Russell's viper venom time
... the other component being the serological testing for anticardiolipin antibodies and anti-β2 glycoprotein-I antibodies using ... Antiphospholipid antibody syndrome is an important marker for recurrent thrombosis, and often warrants indefinite anticoagulant ... This makes the test sensitive to the presence of lupus anticoagulants, because these antibodies interfere with the clot- ... The dRVVT is one component of a workup of a suspected antiphospholipid antibody, ...
Lupus anticoagulant
... lupus anticoagulant is generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and ... In vivo, the antibodies are thought to interact with platelet membrane phospholipids, increasing adhesion and aggregation of ... Its name is a misnomer, as it is actually a prothrombotic antibody. Lupus anticoagulant in living systems cause an increase in ... The name derives from their properties in vitro, as these antibodies increase laboratory coagulation tests such as the ...
ACL
... a common occurrence among participants of several sports Anti-cardiolipin antibodies Administration for Community Living Adult ...
Lupus and pregnancy
... and anticardiolipin antibodies. Neonatal lupus is the occurrence of lupus symptoms in an infant born from a mother with lupus, ... Women pregnant and known to have anti-Ro (SSA) or anti-La antibodies (SSB) often have echocardiograms during the 16th and 30th ... are recommended to be screened for antiphospholipid antibodies, both the lupus anticoagulant (the RVVT and sensitive PTT are ...
Behçet's disease
A meta-analysis published in 2020 identified that the prevalence of antiphospholipid antibodies including anticardiolipin (Odds ... The anti-HSP60 and anti-HSP65 antibodies that target HSPs produced by Streptococci (including S. sanguinis and S. pyogenes) and ... Tanaka, T.; Yamakawa, N.; Koike, N.; Suzuki, J.; Mizuno, F.; Usui, M. (June 1999). "Behçet's disease and antibody titers to ... Islam, Md Asiful (2020). "Prevalence of antiphospholipid antibodies in Behçet's disease: A systematic review and meta-analysis ...
Anti-apolipoprotein antibodies
... also called anti-β2 glycoprotein I antibodies, comprise a subset of anti-cardiolipin antibodies and lupus anticoagulant. These ... Shi W, Chong BH, Hogg PJ, Chesterman CN (1993). "Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein I of ... This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies that specifically ... 2000). "HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European ...
Anti-nuclear antibody
... anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone antibodies, antibodies to ... Anti-mitochondrial antibody. *Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA ... This pattern is associated with anti-dsDNA antibodies, antibodies to nucleosomal components, and anti-histone antibodies. There ... antibodies are antibodies to components of the nuclear membrane and are found in primary biliary cirrhosis (PBC). Each antibody ...
Antibody
Anti-mitochondrial antibody. *Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA ... Antibody mimetic[edit]. Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens. They are ... Asymmetrical antibodies[edit]. Heterodimeric antibodies, which are also asymmetrical and antibodies, allow for greater ... How Lymphocytes Produce Antibody from Cells Alive!. *Antibody applications Fluorescent antibody image library, University of ...
Anti-SSA/Ro autoantibodies
Anti-mitochondrial antibody. *Anti-cardiolipin. Anti-cytoplasm antibody. *Anti-neutrophil cytoplasmic *C-ANCA ... Approximately only 0.1 to 0.5 percent of the general population has the antibody.[citation needed] ... Franceschini F, Cavazzana I (February 2005). "Anti-Ro/SSA and La/SSB antibodies". Autoimmunity. 38 (1): 55-63. doi:10.1080/ ... Immunofluorescence pattern of SS-A and SS-B antibodies. Produced using serum from a patient on HEp-20-10 cells with a FITC ...
抗體 - 維基百科,自由的百科全書
抗心磷脂(英語:Anti-cardiolipin antibodies). 抗細胞質抗體. *抗中性白血球細胞質抗體/ANCA(英語:Anti-neutrophil cytoplasmic antibody) *C-ANCA(英語:C-ANCA) ... 抗體(antibody),又稱免疫球蛋白(immunoglobulin,簡稱Ig)[1],是一種主要由漿細胞分泌,被免疫系統用來鑑別與中和外來物質如細菌、病毒等病原體的大型Y形蛋
List of MeSH codes (D12.776)
... antibodies, antiphospholipid MeSH D12.776.377.715.548.114.323.210.100 - antibodies, anticardiolipin MeSH D12.776.377.715. ... antibodies MeSH D12.776.377.715.548.114.071 - antibodies, anti-idiotypic MeSH D12.776.377.715.548.114.107 - antibodies, ... antibodies, bispecific MeSH D12.776.377.715.548.114.143 - antibodies, blocking MeSH D12.776.377.715.548.114.167 - antibodies, ... antibodies, helminth MeSH D12.776.377.715.548.114.191 - antibodies, heterophile MeSH D12.776.377.715.548.114.224 - antibodies, ...
List of MeSH codes (D12.776.124)
... antibodies, antiphospholipid MeSH D12.776.124.486.485.114.323.210.100 - antibodies, anticardiolipin MeSH D12.776.124.486. ... antibodies, antiphospholipid MeSH D12.776.124.790.651.114.323.210.100 - antibodies, anticardiolipin MeSH D12.776.124.790. ... antibodies MeSH D12.776.124.486.485.114.071 - antibodies, anti-idiotypic MeSH D12.776.124.486.485.114.089 - antibodies, ... antibodies, bispecific MeSH D12.776.124.486.485.114.143 - antibodies, blocking MeSH D12.776.124.486.485.114.167 - antibodies, ...
Undifferentiated connective tissue disease
The presence of the autoantibodies anti-dsDNA, anti-Sm, and anti-cardiolipin has been shown to correlate with the development ... antibodies. It is estimated that up to 25 percent of people with systemic autoimmune disease could be considered to have UCTD. ...
Anti-mitochondrial antibody
Anti-cardiolipin antibodies are another type of AMA, and cardiolipin is found on the inner mitochondrial membrane. A cause of ... M1 - cardiolipin (Anti-cardiolipin antibodies, ACA) M2 - branched-chain alpha-keto acid dehydrogenase complex M3 - outer ... had anti-transglutaminase antibodies, usually associated with coeliac disease. Antibodies Mitochondrion MedlinePlus ... and non-species-specific anti-organelle antibody detected by immunofluorescence: the mitochondrial antibody number 5. Clin Exp ...
Anticardiolipin Antibodies - Heart Disease - MedHelp
Anticardiolipin antibodies are the result of an autoimmune disorder where your body makes antibodies against its own tissues. ... Anticardiolipin Antibodies Tracey__0 I am a 25 year old woman. I consider myself to be physically and mentally fit, I guess ... Whether you are at risk of death from this disorder is hard to determine, but most patients with anticardiolipin antibodies are ... these chemicals cannot prevent clots from developing in the placental blood vessels from the anticardiolipin antibodies. These ...
Anticardiolipin antibodies and COVID-19
A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute ... On lab workup, it was found that she was "positive (for) anticardiolipin IgM and anticardiolipin IgG phospholipid antibodies". ... Anticardiolipin antibodies and COVID-19. News-Medical. https://www.news-medical.net/news/20200610/Anticardiolipin-antibodies- ... A new study has shown that anticardiolipin antibodies are associated with the novel coronavirus infection or severe acute ...
Anti-cardiolipin antibodies - Wikipedia
They are a form of anti-mitochondrial antibody. In SLE, anti-DNA antibodies and anti-cardiolipin antibodies may be present ... Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including ... Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with ... because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. Anti- ...
Anticardiolipin Antibody Medical Definition | Merriam-Webster Medical Dictionary
... an antibody that is directed against phospholipids and especially cardiolipin and is associated with increased risk for ... recurring arterial and venous thromboses -called also anticardiolipin. ... Share anticardiolipin antibody. Post the Definition of anticardiolipin antibody to Facebook Share the Definition of anticardio ... Comments on anticardiolipin antibody. What made you want to look up anticardiolipin antibody? Please tell us where you read or ...
Anti-Cardiolipin Antibody, IgM
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative ... Anti-Cardiolipin Antibodies, IgG & IgM. 2. Anti-Cardiolipin Antibody, IgG. 3. Adenovirus Antibody, IgG. 4. Adenovirus Antibody ... Anti-dsDNA Antibody, IgG. 7. Anti-GBM Antibody, IgA (IFA). 8. Anti-GBM Antibody, IgG (IFA). 9. Anti-GBM Antibody, IgG (ELISA). ... Anti-Glomerular Basement Membrane Antibody, IgA (IFA). 11. Anti-Glomerular Basement Membrane Antibody, IgG (ELISA). ...
Anticardiolipin Antibody: Reference Range, Interpretation, Collection and Panels
... antibody is important in diagnosing antiphospholipid syndrome (APS). According to the Second International Anti-cardiolipin ... encoded search term (Anticardiolipin Antibody) and Anticardiolipin Antibody What to Read Next on Medscape. Related Conditions ... Anticardiolipin (aCL) antibody of immunoglobulin G (IgG) and/or immunoglobulin M (IgM) isotype present in serum (,40 GPL or MPL ... Consensus guidelines on anti-cardiolipin antibody testing and reporting. Pathology. 2004 Feb. 36(1):63-8. [Medline]. ...
anticardiolipin antibodies - Lupus - HealingWell.com Forum
This time the lupus anticoagulant came back negative, but this time the anticardiolipin antibodies came back pos. Doc says to ... HealingWell.com Forum , Diseases & Conditions , Lupus , anticardiolipin antibodies Select A Location. ****** Top of the Forum ... These together can help greatly with some lesser symptoms such as brain fog when it is due to these antibodies.. I would be far ... Either the anticardiolipin tests or the lupus anticoagulant can be positive at any time or negative. Thats why both tests are ...
Degos' disease: association with anticardiolipin antibodies and the lupus anticoagulant. | The BMJ
Lupus anticoagulant, anticardiolipin antibodies and hepatitis C virus infection in thalassaemia
Anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) have been detected in patients with hepatitis C virus (HCV) ... Lupus anticoagulant, anticardiolipin antibodies and hepatitis C virus infection in thalassaemia Br J Haematol. 1998 Sep;102(4): ... Anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) have been detected in patients with hepatitis C virus (HCV) ... None of patients developed any complications related to antiphospholipid antibodies (APL); therefore the clinical significance ...
Anticardiolipin antibodies in women with recurrent abortion
A high level of anticardiolipin antibody activity was detected among 19.23% of the habitual aborters but in none of the ... Daboubi, M.K. (2001). Anticardiolipin antibodies in women with recurrent abortion. EMHJ - Eastern Mediterranean Health ... Enzyme-linked immunosorbent assay was used for detection of anticardiolipin antibodies in a group of 26 patients defined as ... The present study sought to determine whether the level of anticardiolipin antibodies in women with recurrent abortion differed ...
Anticardiolipin Antibodies and Hypercoagulability | Annals of Internal Medicine | American College of Physicians
Anticardiolipin Antibodies and Hypercoagulability Matthew H. Liang, MD; Charles H. Hennekens, MD; Meir J. Stampfer, MD ... Anticardiolipin Antibodies and Hypercoagulability. Ann Intern Med. 1993;118:986-987. doi: 10.7326/0003-4819-118-12-199306150- ... Hess lists several potential reasons why we were not able to detect an association between anticardiolipin antibodies and risk ... Although an association between anticardiolipin antibodies and ischemic stroke cannot be ruled out, as we noted in our paper, ...
Livedoid vasculitis with anticardiolipin antibodies: improvement with danazol - Wakelin - 1998 - British Journal of Dermatology...
Idiopathic intracranial hypertension and anticardiolipin antibodies | Journal of Neurology, Neurosurgery & Psychiatry
1998) Anticardiolipin antibodies are frequently present in patients with idiopathic intracranial hypertension. Arch Neurol 55: ... Israeli prevalence of anticardiolipin antibodies was 3%-5%; APCR 5%-8%; protein C deficiency ,1%; protein S deficiency ,1%, ... The association of idiopathic intracranial hypertension (IIH) or pseudotumour cerebri (PTC) with anticardiolipin antibodies ( ... Anticardiolipin IgG and IgM antibodies were determined by a semiquantitative ELISA assay (Reads,USA). ...
Idiopathic intracranial hypertension and anticardiolipin antibodies | Journal of Neurology, Neurosurgery & Psychiatry
Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia | Annals of Internal Medicine | American College of Physicians
Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia Cesare Masala, MD; Maurizio Sorice, MD; Maria A. Di Prima, MD; ... To the Editor: Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with ... We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among ... Anticardiolipin Antibodies and Pneumocystis carinii Pneumonia. Ann Intern Med. 1989;110:749. doi: https://doi.org/10.7326/0003- ...
Anticardiolipin antibodies in patients with primary immunodeficiency diseases. | Annals of the Rheumatic Diseases
Thirty (21%) had raised anticardiolipin antibody levels compared with only three in 98 age matched controls. The highest ... The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. ... while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. This ...
High Levels of Anticardiolipin Antibodies in Patients with Abnormal Embryo Morphology Who Attended an In Vitro Fertilization...
Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease | Clinical Science
Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease. TJ Hendra, EN Harris, RC Trembath, GRV Hughes, JS ... Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease. TJ Hendra, EN Harris, RC Trembath, GRV Hughes, JS ... Anticardiolipin Antibody Levels in Diabetics with Coronary Artery Disease Message Subject (Your Name) has forwarded a page to ...
Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population
... and anticardiolipin antibodies (ACA) and their relationship to each other in a healthy population of 499 blood donors. Plasma ... Prevalence of lupus anticoagulant and anticardiolipin antibodies in a healthy population Aust N Z J Med. 1990 Jun;20(3):231-6. ... This study was designed to explore the incidence of lupus anticoagulant (LA) and anticardiolipin antibodies (ACA) and their ... Neither ACA nor LA were associated with antinuclear antibodies (ANA) or rheumatoid factor (Rh factor). Thus, in a healthy ...
Inhibitory effects of anticardiolipin antibodies on lymphocyte proliferation and neutrophil phagocytosis. | Annals of the...
... in the presence of anticardiolipin antibodies). The suppression of lymphocyte proliferation by anticardiolipin antibodies was ... Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles ... These newly found activities of anticardiolipin antibodies were mediated by the non-specific membranotropic property of the ... These results suggest that anticardiolipin antibodies exert inhibitory effects on both lymphocytes and phagocytes in addition ...
A case of optic neuritis associated with anticardiolipin antibodies]. | Harvard Catalyst Profiles | Harvard Catalyst
Anticardiolipin Antibodies Testing | Online Lab Testing
IgM anticardiolipin antibodies in human serum or plasma. Order the test online through Personalabs today! ... Anticardiolipin antibodies, IgA, quantitative - TC - 7352. Anticardiolipin antibodies, IgG, quantitative. Anticardiolipin ... Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome. Individuals with the ... This test measures the level of IgA, IgG, IgM anticardiolipin antibodies in human serum or plasma. Order the test online ...
Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase...
Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase ... Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase ... Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly ... Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL ...
IgG Anticardiolipin Antibody Titer |40 GPL and the Risk of Subsequent Thrombo-occlusive Events and Death | Stroke
Antiphospholipid Antibodies in Stroke Study (APASS) group. Anticardiolipin antibodies are an independent risk factor for first ... Matsuura E. Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. J Immunol. 1992;148:3885-3891. ... Antiphospholipid Antibodies in Stroke Study (APASS) group. Anticardiolipin antibodies and the risk of recurrent thrombo- ... Comparison of the effects of anticardiolipin antibodies from patients with the antiphospholipid antibody syndrome and with ...
Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis |...
Affinity-purified anticardiolipin antibody (ACA) preparation. The ACAs of IgG and IgM classes were purified from a reactive ... Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis ... Development of a novel magnetic particle-based agglutination immunoassay for anticardiolipin antibody detection in syphilis ... Analytical sensitivity determined with IgM anticardiolipin antibody (ACA) was 2.6 µg/mL for both NT-MAA and RPR, while IgG ACA ...
Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid...
In conclusion, anticardiolipin antibodies are frequently found in patients with chronic hepatitis C and in these patients they ... Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid ... Anticardiolipin antibodies in chronic hepatitis C: implication of hepatitis C virus as the cause of the antiphospholipid ... In this study anticardiolipin antibodies (immunoglobulin G [IgG] isotype) were determined in serum from 100 patients with ...
Porcine Anti-Cardiolipin antibody (IgM) Quant ELISA Kit | Custom | LSBio
It is a Custom assay which can detect Anti-Cardiolipin antibody (IgM) down to 0.375 Nanograms per millilter. ... Anti-Cardiolipin antibody (IgM) ELISA Kit LS-F41209 is a 96-Well enzyme-linked immunosorbent assay for the Quantitative ... Popular Anti-Cardiolipin antibody (IgM) Elisa Kits. Human Anti-Cardiolipin antibody (IgM) ELISA Kit (Indirect ELISA) - LS- ... Guinea pig Anti-Cardiolipin antibody (IgM) ELISA Kit (Custom ELISA) - LS-F41208 ...
Anti-Cardiolipin/Anti-Phospholipid Antibodies (ACA/APA)
... ELISA method for quantitative determination of Anti-Cardiolipin / Anti ... Rat Antibodies Rat Cytokines Rat ELISA Antibody Pairs Rat ELISA KIts Rat ELISPOT Kits Rat ELISPOT Antibody Pairs ... Human Antibody Human Cytokine Flurospot Kit Human ELISA Antibody pair Human ELISA Kits Human ELISPOT Antibody pairs Human ... Monkey Antibodies Monkey ELISA Antibody Pair Monkey ELISA kit Monkey ELISPOT Antibody Pair Monkey ELISPOT Kit Monkey Cytokine ...
KAKEN - Research Projects | Anticardiolipin antibody and the development of arterial and venous thrombosis. (KAKENHI-PROJECT...
Publications] T.Koike.: Anticardiolipin antibodies and β_2-glycoprotein I. Clin Immunol Immunopathol. 72. 187-192 (1994). *. ... Publications] T.Koike.: Anticardiolipin antibodies and β2-glycoprotein I. Clin Immunol Immunopathol.72. 187-192 (1994). *. ... Publications] T.Koike: Anticardiolipin antibodies and beta2-glycoprotein I. Clin Immunol Immunopathol. 72. 187-192 (1994). * ... Publications] Y.Kita,T.Sumida,I.Iwamoto,Y.Yoshida,T.Koike: V gene analysis of anti-cardiolipin antibodies from (NZW x BXSB) Fl ...
HDCN: Review of abstract by Abu-Shakra et al.
<B>Anticardiolipin antibodies</B> in systemic <B>lupus erythematosus</B>:
...
Anticardiolipin antibodies in systemic lupus erythematosus: clinical and laboratory correlations Am J Med (Dec) 99:624-628 1995 ... Prolonged PTT should be used rather than elevated anticardiolipin antibodies for identifying SLE patients with a high risk of ... A prospective cohort study in a single center examined the link between anticardiolipin antibodies and features of the ... These results contrast with findings in patients with anticardiolipin antibodies without SLE (primary antiphospholipid syndrome ...
ThrombosisCardiolipinSystemicSerumImmunoglobulinELISARecurrentAcquired immunodePhospholipidsAutoantibodiesGlycoproteinTypes of antibodiesPositive for anticardiolipin antibodiesAssociation between anticardiolipin antibodyMiscarriagesAssaysRheumatoidAntiphospholipid antibodies in the bClinicalAntinuclearHigh titersPrevalenceLevels of antiphospholipid antibodiesPregnancyThromboticAntigensACLAProteinsTitersAnticoagulantsBackground AnticardiolipinAPTTIschemic strokeAutoimmune diseasesFetalCofactorSignificancePresence of lupusBody makes antibodiesDetectionDetectArterial and venousQuantitative
Thrombosis32
- Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis. (wikipedia.org)
- Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and pregnancy morbidity in the presence of antiphospholipid antibodies (APLA). (medscape.com)
- Circulating anticardiolipin autoantibodies (aCL-Abs) may be associated with recurrent abortions, deep vein thrombosis, systemic lupus erythematosus, and cerebrovascular accidents. (bmj.com)
- Individuals with the antiphospholipid antibody syndrome (APS) have an increased risk for stroke, myocardial infarction, venous thrombosis, thromboembolism, thrombocytopenia, and/or recurrent miscarriages. (personalabs.com)
- In conclusion, anticardiolipin antibodies are frequently found in patients with chronic hepatitis C and in these patients they may be implicated in the occurrence of thrombosis and in the development of thrombocytopenia. (cun.es)
- Anticardiolipin antibody and the development of arterial and venous thrombosis. (nii.ac.jp)
- A prospective cohort study in a single center examined the link between anticardiolipin antibodies and features of the antiphospholipid syndrome (thrombocytopenia, prolonged PTT, positive direct Coombs test, arterial and venous thrombosis, spontaneous abortions, vasculitic skin ulcers, livedo reticularis, and renal disease) in SLE patients. (hdcn.com)
- Prolonged PTT should be used rather than elevated anticardiolipin antibodies for identifying SLE patients with a high risk of thrombosis. (hdcn.com)
- The link between prolonged PTT and thrombosis may indicate that only those antibodies with lupus anticaogulant activity are pathogenic. (hdcn.com)
- These results contrast with findings in patients with anticardiolipin antibodies without SLE (primary antiphospholipid syndrome), in whom the presence of antibodies is predictive of thrombosis. (hdcn.com)
- The diagnostic criteria require one clinical event (i.e. thrombosis or pregnancy complication) and two antibody blood tests spaced at least three months apart that confirm the presence of either lupus anticoagulant or anti-β 2 -glycoprotein-I (since β 2 -glycoprotein-I antibodies are a subset of anti-cardiolipin antibodies, an anti-cardiolipin assay can be performed as a less specific proxy). (wikipedia.org)
- Clinically important antiphospholipid antibodies (those that arise as a result of the autoimmune process) are associated with thrombosis and vascular disease. (wikipedia.org)
- Presence of these antibodies increases the risk of arterial thrombosis, venous thrombosis, thrombocytopenia and recurrent miscarriage. (machaondiagnostics.com)
- Persistently elevated levels of ACL antibodies are associated with an increased risk of vascular thrombosis and obstetrical complications [3, 4]. (machaondiagnostics.com)
- IgA antiphospholipid antibodies are an independent risk factor for thrombosis. (machaondiagnostics.com)
- The presence of anticardiolipin antibodies increases the risk of blood clots, which can form in both arteries and veins, giving rise to conditions like stroke and deep vein thrombosis (DVT). (fertilitysmarts.com)
- Antiphospholipid syndrome (or antiphospholipid antibody syndrome) is a disorder of coagulation which causes thrombosis in both arteries and veins, as well as recurrent miscarriage. (dailystrength.org)
- Antiphospholipid syndrome (APS) is an autoimmune disease, characterized by thrombosis and pregnancy complications with persistently elevated levels of antiphospholipid antibodies (aPL). (intechopen.com)
- This new approach in the diagnosis of APS leads to the assessment of the risk of thrombosis considering the results of different aPL (lupus anticoagulants (LA), anticardiolipin antibodies (aCL), antibodies against β2GPI (anti-β2GPI), and phosphatidylserine-dependent antiprothrombin antibodies (aPS/PT) (isotypes IgG and IgM). (intechopen.com)
- Anticardiolipin antibodies which are antiphospholipid antibodies by decreasing the prostacyclin production may damage the vascular endothelium and cause thrombosis in the vessels. (elsevier.com)
- Antiphospholipid syndrome (APS or APLS) or antiphospholipid antibody syndrome is a disorder of coagulation that causes blood clots ( thrombosis ) in both arteries and veins as well as pregnancy-related complications such as miscarriage , stillbirth , preterm delivery , or severe preeclampsia . (thefullwiki.org)
- Identification of these cases prompted a retrospective analysis for the presence of IgG anticardiolipin antibody, the most useful laboratory marker of vascular thrombosis in the antiphospholipid syndrome. (nih.gov)
- Anticardiolipin IgG was present in 2/21 (8.8%) recipients who developed a hepatic vessel thrombosis following liver transplantation, compared to 7/111 (6.3%) (p=0.59) in whom transplantation was not complicated by hepatic vessel thrombosis. (nih.gov)
- The presence of IgG anticardiolipin antibody was uncommon in recipients following liver transplantation and was not associated with an increased risk of hepatic vessel thrombosis. (nih.gov)
- The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and obstetric complications (miscarriages, stillbirths). (clinicaltrials.gov)
- The primary aim of this study was to evaluate the incidence of first thrombotic event (deep venous thrombosis (DVT), pulmonary embolism (PE), myocardial infarction (MI), stroke or transient ischaemic attack (TIA) in a nationwide antiphospholipid antibody (aPL) carrier cohort. (nih.gov)
- The antiphospholipid (anticardiolipin) syndrome (APS) is characterized by recurrent venous or arterial thrombosis (clots), recurrent fetal loss, and thrombocytopenia (a reduction in the number of platelets). (healthcentral.com)
- Such antibodies are often found in association with pathological conditions, including thrombosis (clotting), fetal loss, and thrombocytopenia (low platelets). (healthcentral.com)
- Some studies have shown that patients with increased levels of these types of antibodies have a greater risk of thrombosis (blood clot formation), recurrent fetal loss, thrombocytopenia (decreases in blood platelets), hemolytic anemia (decrease in red blood cells), and neurological disorders. (readabstracts.com)
- objective: To measure the accuracy of anticardiolipin antibodies (aCL) in identifying a history of thrombosis among patients with systemic lupus erythematosus (SLE) or the primary antiphospholipid syndrome (PAPS). (uthscsa.edu)
- Nevertheless, the negativity to classic aPL criteria does not imply that other antibodies may be present or involved in the onset of thrombosis. (haematologica.org)
- The 14th International Congress on Antiphospholipid Antibodies Task Force criteria for identifying APS requires testing for cardiolipin antibodies, lupus anticoagulant, and beta-2 glycoprotein antibodies when one of two clinical problems exist, blood clots (thrombosis) or pregnancy morbidity. (labcorp.com)
Cardiolipin26
- Anti-cardiolipin antibodies (ACA) are antibodies often directed against cardiolipin and found in several diseases, including syphilis, antiphospholipid syndrome, livedoid vasculitis, vertebrobasilar insufficiency, Behçet's syndrome, idiopathic spontaneous abortion, and systemic lupus erythematosus (SLE). (wikipedia.org)
- This is in contrast to rheumatoid arthritis with systemic sclerosis (scleroderma) because anti-cardiolipin antibodies are present in both conditions, and therefore may tie the two conditions together. (wikipedia.org)
- Anti-cardiolipin antibodies can be classified in two ways: As IgM, IgG or IgA As β2-glycoprotein dependent or independent In autoimmune disease, ACA are beta-2 glycoprotein dependent In syphilis, ACA are beta-2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory test β2-glycoprotein I has been identified as Apolipoprotein H and is required for the recognition of ACA in autoimmune disease. (wikipedia.org)
- Misra and colleagues (1) reported an increased incidence of anticardiolipin antibodies in patients with infectious mononucleosis and postulated the existence of cross-reactions between infectious (viral) antigens and cardiolipin. (annals.org)
- The presence of antibodies to cardiolipin was determined (by an ELISA) in 143 patients with primary immunodeficiency diseases. (bmj.com)
- Anticardiolipin antibodies purified from serum from patients with systemic lupus erythematosus (SLE) by cardiolipin micelles were studied for their effects on lymphocytes and neutrophils. (bmj.com)
- Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL)-coated latex beads mixed together with beta 2-GPI but were unaffected by addition of excess beta 2-GPI, CL micelles, or CL-coated latex beads alone. (rupress.org)
- LS-F41209 is a 96-well enzyme-linked immunosorbent assay (ELISA) for the Quantitative detection of Porcine Anti-Cardiolipin antibody (IgM). (lsbio.com)
- It is based upon a Custom assay principle and can be used to detect levels of Anti-Cardiolipin antibody (IgM) as low as 0.225 nanograms per millilter. (lsbio.com)
- Serum anti-GQ1b antibodies and IgM anti-cardiolipin antibody were positive. (alliedacademies.org)
- Our case suggests that MFS presenting with proptosis and pain may be associated with serum anti-GQ1b antibodies and IgM anti-cardiolipin antibody. (alliedacademies.org)
- Anti-cardiolipin antibodies are implicated in the pathogenesis of thrombotic diseases and systemic lupus erythematosus (SLE) [ 3 ]. (alliedacademies.org)
- described a Japanese MFS patient with low titer of serum anti-GQ1b antibodies and increased IgG anti-cardiolipin antibody [ 6 ]. (alliedacademies.org)
- Results: Mean level of anti cardiolipin antibody (ACLA) in patients and control groups were 0.192±0.11 and 0.087±0.200 optical density (OD) respectively. (ac.ir)
- What is Anti-Cardiolipin Antibody (ACA)? (fertilitysmarts.com)
- Definition - What does Anti-Cardiolipin Antibody (ACA) mean? (fertilitysmarts.com)
- Anti-cardiolipin antibody (ACA) is a type of antiphospholipid antibody (a blood protein) directed against the fat-like component of the mitochondrial cell membrane called cardiolipin. (fertilitysmarts.com)
- Anti-cardiolipin antibody testing and reporting practices among laboratories participating in a large external Quality Assurance Program. (lww.com)
- In particular, the disease is characterised by antibodies against cardiolipin ( anti-cardiolipin antibodies ) and β 2 glycoprotein I . (thefullwiki.org)
- Antiphospholipid syndrome is tested for in the laboratory using both liquid phase coagulation assays ( lupus anticoagulant ) and solid phase ELISA assays ( anti-cardiolipin antibodies ). (thefullwiki.org)
- The testing of antibodies to the possible individual targets of aPL such as β 2 Glycoprotein 1 and antiphosphatidyl serine is currently under debate as testing for anticardiolipin appears to be currently sensitive and specific for diagnosis of APS even though cardiolipin is not considered an in vivo target for antiphospholipid antibodies. (thefullwiki.org)
- Alterations in the level of anticoagulant proteins, disturbances of endothelial cell function, and the presence of cardiolipin antibodies and Factor V Leiden mutation may increase the cumulative thrombotic risk in MPD besides the risk imposed by platelet activation. (cdc.gov)
- Objective To explore the relationship between serum anti - cardiolipin antibodies ( ACA ) and recurrent cerebral infarction ( RCI),and to provide the clinical evidence for the prevention and treatment of RCI. (bvsalud.org)
- However, older patients had a higher incidence of antibodies against cardiolipin, a fat that is present in the membranes surrounding cells. (readabstracts.com)
- Anticardiolipin antibodies (aCL) are specialized proteins that specifically bind and inactivate the phosphate-containing compound cardiolipin. (readabstracts.com)
- Cardiolipin antibodies (IgG, IgM, and sometimes IgA) are frequently ordered since they are the most common antiphospholipid antibodies. (labcorp.com)
Systemic15
- Anticardiolipin antibodies (ACA) and lupus anticoagulant (LA) have been detected in patients with hepatitis C virus (HCV) infection and have been associated in autoimmune diseases (i.e. systemic lupus erythematosus) with an increased risk of thromboembolic events. (nih.gov)
- The appearance of anticardiolipin antibodies (aCL) in patients with systemic lupus erythematosus (SLE) and other collagen diseases is associated with variety of clinical features, including arterial and venous thromboembolic manifestation, recurrent fetal loss and thrombocytopenia. (nii.ac.jp)
- T Koike: 'Antibodies to β_2-glycoprotein I and clinical manifestaton in patients with systemic lupus erythematousus. (nii.ac.jp)
- Anticardiolipin antibodies (aCL) are found in sera of patients with systemic lupus erythematosus (SLE) and related connective tissue diseades. (nii.ac.jp)
- A previous study showed a reduction in antiphospholipid antibodies among patients with systemic lupus erythematosus who received belimumab. (rheumatologyadvisor.com)
- This post-hoc analysis evaluated the effect of belimumab 10 mg/kg vs placebo on antiphospholipid antibodies (aPL) titers in patients with systemic lupus erythematosus (SLE). (rheumatologyadvisor.com)
- Chatzidionysiou K, Samoli E, Sfikakis PP, Tektonidou MG. Effect of belimumab treatment on antiphospholipid antibodies levels: post-hoc analysis based on two randomised placebo-controlled trials in systemic lupus erythematosus [published online November 11, 2019]. (rheumatologyadvisor.com)
- McHugh, NJ & Maddison, PJ 1989, ' HLA-DR antigens and anticardiolipin antibodies in patients with systemic lupus erythematosus ', Arthritis & Rheumatism , vol. 32, no. 12, pp. 1623-1624. (bath.ac.uk)
- Antibodies against PLs have been commonly found in patients with autoimmune diseases such as systemic lupus erythematosus and primary antiphospholipid syndrome, in which clinical manifestations (mainly thrombotic events) have been directly attributed to antibodies against PLs. (cdc.gov)
- Reticulate and stellate acral pigmentation associated with systemic lupus erythematosus and high titers of circulating anticardiolipin antibodies: a possible association with acral microlivedo. (elsevier.com)
- A Hispanic man with a twenty-eight year history of systemic lupus erythematosus (SLE) and a high titer of anticardiolipin IgG antibodies was noted to have reticulate and stellate acral pigmentation. (elsevier.com)
- HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. (cdc.gov)
- Our objective was to determine the HLA-DPB1 allele associations of anticardiolipin (aCL) and anti-beta2GPI (a(beta)2GPI) antibodies, and of clinical manifestations of the antiphospholipid syndrome (APS), in systemic lupus erythematosus (SLE). (cdc.gov)
- Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by arterial and venous thrombotic manifestations and/or pregnancy-related complications in patients with persistently high antiphospholipid antibodies (aPL), the most common being represented by anticardiolipin antibodies (aCL), anti-beta 2 glycoprotein-I (aβ2GPI), and lupus anticoagulant (LAC). (haematologica.org)
- 3 This definition was derived from clinical observation of recurrent miscarriages, central nervous system disease, and recurrent venous thromboembolism (VTE) in patients with systemic lupus erythematosus (SLE) and serum positivity for anticardiolipin antibodies (aCL) and lupus anticoagulant (LAC). (haematologica.org)
Serum11
- The presence of serum anticardiolipin (aCL) antibody without clinical symptoms does not support a diagnosis of antiphospholipid syndrome (APS). (medscape.com)
- This test measures the level of IgA, IgG, IgM anticardiolipin antibodies in human serum or plasma. (personalabs.com)
- In this study anticardiolipin antibodies (immunoglobulin G [IgG] isotype) were determined in serum from 100 patients with chronic hepatitis C and 52 healthy controls. (cun.es)
- Here we report the first Chinese patient with MFS who showed proptosis and pain and had serum anti-GQ1b antibodies and IgM anticardiolipin antibody. (alliedacademies.org)
- Miller Fisher syndrome (MFS) is a variant of Guillain-Barre syndrome (GBS) characterized by acute onset of ophthalmoplegia, ataxia and areflexia, and positive serum anti- GQ1b antibodies. (alliedacademies.org)
- Persistent elevation of IgG anticardiolipin antibodies (aCL) was found in his serum and may be a marker of endothelial damage associated with either VWF or the patient's coincidental valvular heart disease. (bath.ac.uk)
- An antibody found in the serum of patients with rheumatoid arthritis but not in those with other joint or soft tissue diseases. (thefreedictionary.com)
- An antibody that cross-reacts with smooth muscle collagen and the gluten in wheat, found in the serum of people with celiac sprue and some related autoimmune diseases. (thefreedictionary.com)
- An antibody formed against the chemical components of nerves, found in the serum of those with Guillain-Barré syndrome. (thefreedictionary.com)
- An antibody formed against the gluten in wheat, found in the serum of people with celiac sprue. (thefreedictionary.com)
- One 5ml non-anticoagulated serum sample for Anticardiolipin testing. (guysandstthomas.nhs.uk)
Immunoglobulin4
- Anticardiolipin Antibodies and Immunoglobulin M and A in Graves' Disease', Iranian Journal of Medical Sciences , 30(1), pp. 6-9. (ac.ir)
- Although belimumab did not show any significant effect over time on anticardiolipin (aCL) antibodies immunoglobulin G (IgG) or immunoglobulin M (IgM), the drug did have an effect on IgG and IgA in patients receiving concomitant antimalarials, according to study results published in Annals of the Rheumatic Diseases . (rheumatologyadvisor.com)
- There are three different types of ACA, including IgG, IgM, and IgA (Ig is the short form for immunoglobulin, which means antibody). (fertilitysmarts.com)
- an immunoglobulin molecule having a specific amino acid sequence that gives each antibody the ability to adhere to and interact only with the antigen that induced its synthesis. (thefreedictionary.com)
ELISA7
- Anticardiolipin IgG and IgM antibodies were determined by a semiquantitative ELISA assay (Reads,USA). (bmj.com)
- Epitopes described in False positive ELISA tests for anticardiolipin antibodies in sera from patients with repeated abortion, rheumatologic disorders and primary biliary cirrhosis: correlation with elevated polyclonal IgM and implications for patients with repeated abortion. (iedb.org)
- ELISA is the test used to detect these antibodies, IgM and IgG isotypes. (medscape.com)
- Measurement of Anticardiolipin Antibody Levels of anticardiolipin antibody were determined with use of an ELISA according to the modified method of Loizou et al. (healthdocbox.com)
- In 11/61 leprosy sera increased levels of IgG antibodies against β 2 -GPI were found by ELISA. (elsevier.com)
- Leprosy anti-β 2 -GPI antibodies appear to be a separate antibody population recognizing only β 2 -GPI adsorbed on the ELISA plate. (elsevier.com)
- aCL and a(beta)2GPI antibodies were measured by ELISA. (cdc.gov)
Recurrent11
- The present study sought to determine whether the level of anticardiolipin antibodies in women with recurrent abortion differed from that in the general population. (who.int)
- The data cited by Dr. Anand [1] suggest that when treatment is warranted, warfarin may be more effective than aspirin in preventing recurrent thrombotic events in patients with elevated antiphospholipid antibody levels. (annals.org)
- Among these, the presence of IgM ACA more strongly predicts the occurrence of recurrent miscarriages and is a better indicator of pregnancy outcome than other types of antibodies. (fertilitysmarts.com)
- PROBLEM: Anticardiolipin antibodies (aCL) are commonly associated with recurrent pregnancy loss, though the mechanism is uncertain. (elsevier.com)
- Anticardiolipin Antibody test is done for multiple reasons, but primarily for detection of blood clots and autoimmune diseases such as rheumatoid arthritis, lupus and also recurrent miscarriages. (1mg.com)
- These antibodies increase the risk of developing recurrent inappropriate blood clots in both veins and arteries. (labtestsonline.org)
- Patient(s): with recurrent fetal miscarriage who were positive for anticardiolipin antibody and normal fertile women. (healthdocbox.com)
- These include recurrent fetal miscarriage, intrauterine fetal growth retardation, and preeclampsia, in connection with positivity for antiphospholipid antibodies. (healthdocbox.com)
- It is also possible that HLA antigen systems are associated with recurrent fetal miscarriage in patients who are positive for antiphospholipid antibodies. (healthdocbox.com)
- Several reports based on serologic HLA typing have pointed out the positive association between patients with recurrent fetal miscarriage who are positive for antiphospholipid antibodies and specific HLA alleles (13, 14). (healthdocbox.com)
- Antiphospholipid antibodies are also associated with low platelet counts ( thrombocytopenia ) and with the risk of recurrent miscarriages (especially in the second and third trimester), premature labor, and pre-eclampsia . (labtestsonline.org)
Acquired immunode1
- We observed that in the acquired immunodeficiency syndrome (AIDS), anticardiolipin antibodies occurred almost exclusively among those patients who had active P. carinii pneumonia (2). (annals.org)
Phospholipids8
- Antiphospholipid syndrome is an autoimmune disease , in which "antiphospholipid antibodies" (anticardiolipin antibodies and lupus anticoagulant) react against proteins that bind to anionic phospholipids on plasma membranes . (wikipedia.org)
- Antiphospholipid (APL) antibodies are group of antibodies directed against epitopes on plasma proteins that are uncovered by binding of these proteins to anionic phospholipids on plasma membranes. (medscape.com)
- Antiphospholipid syndrome (APS) is a condition in which antibodies that normally function to protect us from offending agents, start attacking the body's own tissues - phospholipids in this case. (fertilitysmarts.com)
- In these patients, antibodies against PLs are specific for a neoepitope constituted by the union of β 2 GPI, a lipid-binding coagulation inhibitor, to the cellular membrane phospholipids ( 2 ). (cdc.gov)
- Antiphospholipid antibody (aPL) is an antibody that reacts with negatively charged phospholipids, molecules which are common constituents of cell membranes. (healthcentral.com)
- Antiphospholipid antibodies are a group of immune proteins ( antibodies ) that the body mistakenly produces against itself in an autoimmune response to phospholipids. (labtestsonline.org)
- People with antibodies to phospholipids (aPL) may have a very high risk of forming blood clots. (umm.edu)
- In this condition, your body makes antibodies that attack a kind of fat (phospholipids) in cells. (ahealthyme.com)
Autoantibodies4
- Patients with selective IgA deficiency also showed a high prevalence of this autoantibody (32%), while patients with severe defects in antibody production showed a low prevalence or did not have such autoantibodies. (bmj.com)
- Antiphospholipid antibodies are a type of autoantibodies that have been implicated in the occurrence of thrombocytopenia and thrombotic events and have been described in autoimmune disorders and diverse viral diseases. (cun.es)
- Autoantibodies called antinuclear antibodies (ANA) are detectable in most, although not all, patients with SLE. (adam.com)
- Particular autoantibodies are associated with SLE, but the older group less frequently developed antibodies against DNA (the body's genetic molecules) as well as another antibody known as anti-Ro. (readabstracts.com)
Glycoprotein19
- Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. (wikipedia.org)
- Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. (rupress.org)
- Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly bind to beta 2-glycoprotein I (beta 2-GPI), which is adsorbed to an oxidized polystyrene surface. (rupress.org)
- T Koike: 'Human β_2-glycoprotein I as an anticardiolipin cofactor determined using delated mutants expressed by a basculovirus system. (nii.ac.jp)
- Sieven A.Krihs: 'Epitope specificity of monoclonal anti-β_2-glycoprotein I antibodies derived from patients with the antiphospholipid syndrome. (nii.ac.jp)
- G.R.V.Hughes: 'β_2-glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. (nii.ac.jp)
- Anticardiolipin antibodies and β_2-glycoprotein I.' Clin Immunol Immunopathol. (nii.ac.jp)
- Publications] Igarashi.M., E.Matsuura, H.Nagae, K.Ichikawa, D.A.Triplett, T.Koike: 'Human beta2-glycoprotein I as an anticardiolipin cofactor determined using delated mutants expressed by a basculovirus system. (nii.ac.jp)
- Publications] Min-Xia Wang.D.A.Kandiah, K.Ichikawa, M.Khamashta, G.Hughes, T.Koike, R.Roubey, Steven A.Krilis: 'Epitope specificity of monoclonal anti-beta2-glycoprotein I antibodies derived from pstients with the antiphospholipid syndrome. (nii.ac.jp)
- Publications] Igarashi,M.,et al: 'Expression of anticardiolipin cofactor,human β_2-glycoprotein I,by a recombinant baculovirus/insect cell system. (nii.ac.jp)
- Publications] Matsuura,E.,et al: 'Molecular definition of human β_2-glycoprotein I(β_2-GPI)by cDNA cloning and inter-species differences of β_2-GPI in alternation of anticardiolipin binding. (nii.ac.jp)
- Publications] Koike, T., Matuura, E.: 'Anticardiolipin antibody and beta2-glycoprotein I : in Intractable Vasculitis Syndromes. (nii.ac.jp)
- The most commonly used tests to detect APL include lupus anticoagulant (LAC), anticardiolipin (ACL) antibodies, and anti-β 2 -glycoprotein I antibodies. (medscape.com)
- Per antiphospholipid syndrome diagnostic criteria, these anti-β 2 -glycoprotein I antibodies of IgG and/or IgM isotype should be present in the in plasma, in a titer greater than the 99th percentile to be considered a positive test result. (medscape.com)
- Fingerprint Dive into the research topics of 'Anticardiolipin Antibodies in Patients With Pregnancy Loss Induce Factor Xa Production in the Presence of (β2‐Glycoprotein I'. Together they form a unique fingerprint. (elsevier.com)
- Anticardiolipin antibody (ACA) includes beta2-glycoprotein I-dependent (β2-GPI-dependent) and β2-GPI-independent forms. (ovid.com)
- Anticardiolipin (aCL), anti-β 2 -glycoprotein I (anti-β 2 -GPI), anti-prothrombin (aPT) and anti-annexin V (aANXV) antibodies are anti-phospholipid antibodies (aPL) with different antigenic and diagnostic specificities. (biomedcentral.com)
- The most frequently detectable aPL are anticardiolipin antibodies (aCL), antiβ2-glycoprotein I antibodies (anti-β2-GPI), and lupus anticoagulant (LAC). (haematologica.org)
- Beta-2 glycoprotein 1 testing may be ordered along with the other antiphospholipid antibodies to detect their presence and to provide the healthcare practitioner with additional information. (labcorp.com)
Types of antibodies1
- the two types of antibodies act independently. (wikipedia.org)
Positive for anticardiolipin antibodies2
- I've tested positive for anticardiolipin antibodies. (healthtap.com)
- Four out of 20 patients (20%) were positive for anticardiolipin antibodies. (elsevier.com)
Association between anticardiolipin antibody1
- BACKGROUND AND PURPOSE: The association between anticardiolipin antibody (aCL) and ischemic stroke is controversial, and there are few case-control studies of Asian populations. (elsevier.com)
Miscarriages2
- This was done to clarify the role of the HLA class II antigens in patients positive for anticardiolipin antibody who repeatedly have fetal miscarriages. (healthdocbox.com)
- Antiphospholipid syndrome (APS) , also called Hughes syndrome, is a recognized group of signs and symptoms that includes the formation of blood clots, miscarriages, platelet deficiency (thrombocytopenia), and the presence of one or more antiphospholipid antibodies. (labtestsonline.org)
Assays2
- We studied the effect of β 2 -GPI on binding of antibodies in sera from patients with leprosy and patients with the antiphospholipid syndrome (APS) to CL in enzyme-linked immunosorbent assays (ELISAs). (elsevier.com)
- Moreover, the assays to measure the levels of these antibodies have not yet been standardized. (haematologica.org)
Rheumatoid6
- Neither ACA nor LA were associated with antinuclear antibodies (ANA) or rheumatoid factor (Rh factor). (nih.gov)
- This study evaluated anticardiolipin and rheumatoid factor, such as IgA and IgM antibodies in patients with Graves' disease. (ac.ir)
- Patients and methods: Anticardiolipin and rheumatoid factor were measured in sera of 84 patients (29 male, 55 female) with evidence of Graves' disease and 41 healthy individuals (15 male, 26 female) with negative history of hyperthyroidism and other autoimmune diseases. (ac.ir)
- Antinuclear antibodies also occur in patients with rheumatoid arthritis, Sjögren's syndrome, and scleroderma. (thefreedictionary.com)
- IgG and IgM anticardiolipin antibodies following treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis. (duke.edu)
- OBJECTIVE: To assess the occurrence of anticardiolipin antibodies (aCL) in patients with early rheumatoid arthritis (RA) receiving treatment with infliximab plus methotrexate (MTX) versus MTX alone. (duke.edu)
Antiphospholipid antibodies in the b1
- [5] Some studies have shown the presence of antiphospholipid antibodies in the blood and spinal fluid of patients with psychological symptoms. (wikipedia.org)
Clinical5
- In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE. (cdc.gov)
- Despite three decades of research, the pathophysiological basis of the association between clinical disease and antiphospholipid antibodies (aPL) remains uncertain. (ispub.com)
- That aPL are associated with clinical disease in non-autoimmune patients supports the notion that the antibodies are pathogenic ( 1 ). (ispub.com)
- This research is in continuous development as the clinical relevance of these antibodies is far from being completely clarified. (haematologica.org)
- In this review, we will discuss criteria for defining the SN-APS, the new potential non-criteria antibodies implied in SN-APS and its clinical management. (haematologica.org)
Antinuclear2
- Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortion. (wikipedia.org)
- A doctor will base an SLE diagnosis on certain specific criteria including symptom history and the results of blood tests for antinuclear antibodies. (adam.com)
High titers1
- Reticulate and stellate acral pigmentation should be considered a possible manifestation of SLE and high titers of anticardiolipin antibodies, or a consequence of therapy. (elsevier.com)
Prevalence3
- The overall prevalence of antibodies gradually increased with age, reaching 23.7% in the age group 35-45 years. (who.int)
- The prevalence of anti-β 2 -GPI and aANXV antibodies did not differ between patient groups. (biomedcentral.com)
- The prevalence of antiphospholipid antibodies (aPL) in the general population is difficult to estimate due to the lack of population-based studies. (haematologica.org)
Levels of antiphospholipid antibodies1
- Low levels of antiphospholipid antibodies may be associated with HIV , Lyme disease , and some cancers. (labtestsonline.org)
Pregnancy4
- Enzyme-linked immunosorbent assay was used for detection of anticardiolipin antibodies in a group of 26 patients defined as habitual aborters [at least three consecutive spontaneous abortions], and in a control group of 26 patients each of whom had had at least one live birth without pregnancy wastage. (who.int)
- The presence of antiphospholipid antibodies (aPL) in the absence of blood clots or pregnancy-related complications does not indicate APS (see below for the diagnosis of APS). (wikipedia.org)
- Yesterday I lost another pregnancy of multiples to antiphospholipid antibody syndrome. (dailystrength.org)
- Anticardiolipin Antibodies and Pregnancy . (healthcentral.com)
Thrombotic5
- In patients with no evidence of liver disease and a history of thrombotic events, hepatitis C markers were absent in all cases who tested negatively for anticardiolipin antibodies (n = 37), but were present in 16.7% of those positive for anticardiolipin (n = 36) (P = .01). (cun.es)
- Occult HCV infection is present in a significant proportion of patients with thrombotic disorders and positive for anticardiolipin (the antiphospholipid syndrome). (cun.es)
- Persistent antiphospholipid antibody (aPL) in asymptomatic carriers as a risk factor for future thrombotic events: a nationwide prospective study. (nih.gov)
- 1 patient had posi- non-central nervous system thrombotic events (e.g., tive antiphospholipid antibodies. (cdc.gov)
- In kidney transplant recipients, anticardiolipin (ACL) antibodies without antiphospholipid syndrome (APS) are found in up to 38% of patients and could be associated with thrombotic events (TEs). (cepia.team)
Antigens3
- cytotoxic antibody any specific antibody directed against cellular antigens, which when bound to the antigen, activates the complement pathway or activates killer cells, resulting in cell lysis. (thefreedictionary.com)
- Antibodies neutralize or destroy antigens in several ways. (thefreedictionary.com)
- In a normal immune system, the body produces proteins (antibodies) to fight viruses, toxins and other potentially harmful foreign substances (antigens). (adam.com)
ACLA1
- The incidence and significance of IgG and IgM anticardiolipin in antibodies (aCLa) in patients with acute rheumatic fever (ARF), chronic rheumatic heart disease (CRHD) and streptococcal pharyngitis have been investigated in order to determine whether these antibodies play an important role in the pathogenesis and if they are markers that can be used to confirm disease activity. (ege.edu.tr)
Proteins2
- Antiphospholipid syndrome (APS) is an autoimmune disorder , meaning that the body's immune system makes proteins known as antibodies that mistakenly attack its own cells or tissues. (labtestsonline.org)
- But in APS, antibodies attack the lipid-proteins found in the outermost layer of cells (cell membranes) and platelets. (labtestsonline.org)
Titers1
- antibodies against β 2 GPI were undetectable, and only IgG anticardiolipin was still detected at lower titers (+33). (cdc.gov)
Anticoagulants2
- The presence of lupus anticoagulants and anticardiolipin antibodies (aCL) has been associated with young victims of myocardial infarction (heart attack). (healthcentral.com)
- Lupus anticoagulants are antibodies against substances in the lining of cells. (umm.edu)
Background Anticardiolipin2
- Background Anticardiolipin antibodies (aCL) have been associated with an increased risk of stroke and thrombo-occlusive events. (ahajournals.org)
- Background Anticardiolipin antibodies (ACL-Ab) are associated with various neurologic syndromes, but idiopathic intracranial hypertension (IIH) has only rarely been reported in this context. (jamanetwork.com)
APTT1
- The patient on initial screening will typically have been found to have a prolonged APTT that does not correct in an 80:20 mixture with normal human plasma (50:50 mixes with normal plasma are insensitive to all but the highest antibody levels). (thefullwiki.org)
Ischemic stroke2
- Dr. Hess lists several potential reasons why we were not able to detect an association between anticardiolipin antibodies and risk for ischemic stroke. (annals.org)
- Although an association between anticardiolipin antibodies and ischemic stroke cannot be ruled out, as we noted in our paper, the null findings are consistent with another prospective study among survivors of acute myocardial infarction [2] . (annals.org)
Autoimmune diseases1
- SLE is one of the autoimmune diseases in which antibodies are inappropriately made against the body's own molecules. (readabstracts.com)
Fetal1
- Pregnant patients who have anticardiolipin antibodies are at increased risk for miscarriage, fetal growth retardation and stillbirth. (healthcentral.com)
Cofactor1
- Publications] Matsuura,E.,et al: 'Heterogeneity of anticardiolipin antibodies defined by the anticardiolipin cofactor. (nii.ac.jp)
Significance1
- Anticardiolipin and Lupus Anticoagulant Testing and Significance. (machaondiagnostics.com)
Presence of lupus1
- The antiphospholipid syndrome is characterised by arterial and venous thromboses affecting small and large vessels, together with the presence of lupus anticoagulant and anticardiolipin antibodies. (nih.gov)
Body makes antibodies1
- Anticardiolipin antibodies are the result of an autoimmune disorder where your body makes antibodies against its own tissues. (medhelp.org)
Detection2
- Due to a lack of sustainable in vitro culture techniques for T. pallidum , unavailability of Food and Drug Administration (FDA)-cleared molecular tests and limitations associated with direct detection tests such as dark field microscopy, indirect serological tests that detect non-treponemal and treponemal antibodies remain the mainstay for routine syphilis detection. (bmj.com)
- In order to improve APS diagnosis, several new approaches in aPL detection have recently been suggested, such as multiline immunodot assay, detection of aPL by flow cytometry using beads with particular surface properties, and the newly developed automated BioPlex system technology for parallel detection of aCL and anti-β2GPI antibodies of IgG, IgA, and IgM isotypes. (intechopen.com)
Detect1
- After a complete medical history including your family history and a physical examination, your physician will order blood tests that can detect antiphospholipid antibodies, including lupus anticoagulant and anticardiolipin antibodies. (healthcentral.com)
Arterial and venous1
- We have evaluated the risk factors for arterial and venous thromboses in a wide variety of renal patients with both glomerular and non‐glomerular diseases, including the presence of nephrotic syndrome, inborn and acquired coagulation defects (i.e., factor V Leiden, MTHFR gene mutation, 20210 prothrombin gene mutation, and antiphospholipid antibodies), corticosteroid treatment, and dyslipidemia. (intechopen.com)
Quantitative2
- The quantitative measurement of anticardiolipin (aCL) antibody is important in diagnosing antiphospholipid syndrome (APS). (medscape.com)
- Twenty patients with eclampsia were studied for the presence of anticardiolipin antibodies by the standard microflocculation test (quantitative) used in the VDRL. (elsevier.com)