Antibiotics, Antineoplastic
Antibiotic Prophylaxis
Microbial Sensitivity Tests
Drug Resistance, Bacterial
Drug Resistance, Microbial
Streptomyces
Antineoplastic Agents, Phytogenic
Aminoglycosides
Leukemia P388
Macrolides
Bacteria
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Gentamicins
Drug Screening Assays, Antitumor
Drug Utilization
Doxorubicin
beta-Lactams
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Antineoplastic Agents, Alkylating
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Neoplasms
Penicillins
A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)
Molecular Structure
Fermentation
Erythromycin
A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Ampicillin
Tetracycline
Staphylococcus aureus
Antineoplastic Combined Chemotherapy Protocols
Drug Resistance, Multiple, Bacterial
Lactones
Cephalosporins
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Phospholipid Ethers
Phospholipids which have an alcohol moiety in ethereal linkage with a saturated or unsaturated aliphatic alcohol. They are usually derivatives of phosphoglycerols or phosphatidates. The other two alcohol groups of the glycerol backbone are usually in ester linkage. These compounds are widely distributed in animal tissues.
Dose-Response Relationship, Drug
Tumor Cells, Cultured
Ellipticines
Gallium
Gloves, Protective
Coverings for the hands, usually with separations for the fingers, made of various materials, for protection against infections, toxic substances, extremes of hot and cold, radiations, water immersion, etc. The gloves may be worn by patients, care givers, housewives, laboratory and industrial workers, police, etc.
Bryostatins
Kanamycin
Anti-Infective Agents
Vancomycin
Cell Survival
Pseudomonas aeruginosa
Streptomycin
Gram-Negative Bacteria
Amaryllidaceae Alkaloids
Drug Evaluation, Preclinical
Depsipeptides
Drug Resistance, Multiple
Cefazolin
Penicillin G
A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.
Aster Plant
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Lactams
Occupational Exposure
Chloramphenicol
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
Chemistry
Chemical Phenomena
Tobramycin
Equipment Contamination
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Daunorubicin
Treatment Outcome
Drug Therapy, Combination
Paclitaxel
Neomycin
Magnetic Resonance Spectroscopy
Medical Secretaries
Physician's Practice Patterns
Lincomycin
Oncology Nursing
Azithromycin
Drug Administration Schedule
Cell Division
Structure-Activity Relationship
Decontamination
Amoxicillin
beta-Lactamases
Sulindac
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Protective Devices
Polymyxins
Culture Media
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Xenograft Model Antitumor Assays
Peptides, Cyclic
Leucomycins
Oxytetracycline
Staphylococcus
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Lethal Dose 50
Micromonospora
Ceftriaxone
Drug Resistance, Neoplasm
Thienamycins
Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.
Biofilms
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Anthraquinones
Bacteremia
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Protective Clothing
Mutation
Enzyme Inhibitors
Gram-Negative Bacterial Infections
Neoplasms, Experimental
Urinary Tract Infections
Drug Interactions
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Plasmids
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
6-Mercaptopurine
Phlebitis
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Prodrugs
Cefuroxime
Epothilones
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Inhibitory Concentration 50
Drug Evaluation
Tetracyclines
Physicochemical Phenomena
Carcinoma, Ehrlich Tumor
Bleomycin
Colony Count, Microbial
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Rifampin
A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Amikacin
Chemistry, Physical
Fluorouracil
Bacitracin
A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)
Metronidazole
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Neoplasm Transplantation
Chromatography, High Pressure Liquid
Amsacrine
Streptococcus pneumoniae
Actinomycetales
Gram-Positive Bacterial Infections
Environmental Monitoring
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Streptomyces coelicolor
Methotrexate
Penicillin V
Antifungal Agents
Drug Compounding
Topoisomerase II Inhibitors
Enterococcus
Community-Acquired Infections
Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.
Inappropriate Prescribing
Mice, Nude
Teicoplanin
Cephalexin
Ceftazidime
Anthracyclines
Staphylococcus epidermidis
Base Sequence
Enediynes
Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane. (1/4684)
-The clinical efficacy of anthracycline antineoplastic agents is limited by a high incidence of severe and usually irreversible cardiac toxicity, the cause of which remains controversial. In primary cultures of neonatal and adult rat ventricular myocytes, we found that daunorubicin, at concentrations /=10 micromol/L induced necrotic cell death within 24 hours, with no changes characteristic of apoptosis. To determine whether reactive oxygen species play a role in daunorubicin-mediated apoptosis, we monitored the generation of hydrogen peroxide with dichlorofluorescein (DCF). However, daunorubicin (1 micromol/L) did not increase DCF fluorescence, nor were the antioxidants N-acetylcysteine or the combination of alpha-tocopherol and ascorbic acid able to prevent apoptosis. In contrast, dexrazoxane (10 micromol/L), known clinically to limit anthracycline cardiac toxicity, prevented daunorubicin-induced myocyte apoptosis, but not necrosis induced by higher anthracycline concentrations (>/=10 micromol/L). The antiapoptotic action of dexrazoxane was mimicked by the superoxide-dismutase mimetic porphyrin manganese(II/III)tetrakis(1-methyl-4-peridyl)porphyrin (50 micromol/L). The recognition that anthracycline-induced cardiac myocyte apoptosis, perhaps mediated by superoxide anion generation, occurs at concentrations well below those that result in myocyte necrosis, may aid in the design of new therapeutic strategies to limit the toxicity of these drugs. (+info)Inhibition of angiogenesis induces chromaffin differentiation and apoptosis in neuroblastoma. (2/4684)
Inhibition of angiogenesis has been shown to reduce tumor growth, metastasis, and tumor microvascular density in experimental models. To these effects we would now like to add induction of differentiation, based on biological analysis of xenografted human neuroblastoma (SH-SY5Y, WAG rnu/rnu) treated with the angiogenesis inhibitor TNP-470. Treatment with TNP-470 (10 mg/kg s.c., n = 15) reduced the tumor growth by 66% and stereological vascular parameters (Lv, Vv, Sv) by 36-45%. The tumor cell apoptotic fraction increased more than threefold, resulting in a decrease in viable tumor cells by 33%. In contrast, the mean vascular diameter (29 microm) and the mean tumor cell proliferative index (49%) were unaffected. TNP-470-treated tumors exhibited striking chromaffin differentiation of neuroblastoma cells, observed as increased expression of insulin-like growth factor II gene (+88%), tyrosine hydroxylase (+96%), chromogranin A, and cellular processes. Statistical analysis revealed an inverse correlation between differentiation and angiogenesis. It is suggested that by inhibiting angiogenesis, TNP-470 induces metabolic stress, resulting in chromaffin differentiation and apoptosis in neuroblastoma. Such agonal differentiation may be the link between angiostatic therapy and tumor cell apoptosis. (+info)Novel selective inhibitors for human topoisomerase I, BM2419-1 and -2 derived from saintopin. (3/4684)
Compounds BM2419-1 and -2 were isolated from a culture broth of a fungus Paecilomyces sp. BM2419. It was shown that these novel compounds were artifacts derived from saintopin, a dual inhibitor of topoisomerase I and II by independent processes. In the human topoisomerase I inhibition assay using the recombinant Saccharomyces cerevisiae, BM2419-1 and -2 inhibited selectively the yeast growth dependent on human topoisomerase I induction with IC50 values of 0.3 ng/ml and 6.0 ng/ml, respectively. (+info)Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties. (4/4684)
A novel macrolide, apicularen A, was produced by several species of the genus Chondromyces. Initially it was discovered by bioassay-guided RP-HPLC-fractionation of culture extracts of Chondromyces robustus, strain Cm a13. Apicularen A showed no antimicrobial activity, but was highly cytotoxic for cultivated human and animal cells, with IC50 values ranging between 0.1 and 3 ng/ml. A cometabolite of apicularen A, the N-acetylglucosamine glycoside apicularen B, was distinctly less cytotoxic with IC50 values between 0.2 and 1.2 microg/ml, and showed weak activity against a few Gram-positive bacteria. Apicularen A is chemically closely related to the salicylihalamides A and B from the marine sponge Haliclona sp. (+info)BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties. (5/4684)
A new antifungal antibiotic, BE-31405, was isolated from the culture broth of a fungal strain, Penicillium minioluteum F31405. BE-31405 was isolated by adsorption on high porous polymer resin (Diaion HP-20), followed by solvent extraction, precipitation and crystallization. BE-31405 showed potent growth inhibitory activity against pathogenic fungal strains such as Candida albicans, Candida glabrata and Cryptococcus neoformans, but did not show cytotoxic activity against mammalian cells such as P388 mouse leukemia. The mechanism studies indicated that BE-31405 inhibited the protein synthesis of C. albicans but not of mammalian cells. (+info)Diperamycin, a new antimicrobial antibiotic produced by Streptomyces griseoaurantiacus MK393-AF2. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. (6/4684)
Antibacterial antibiotics, diperamycin (1) was produced in the culture broth of Streptomyces griseoaurantiacus MK393-AF2. Various spectroscopic analyses of 1 suggested that 1 belonged to a member of cyclic hexadepsipeptide antibiotic. Antibiotic 1 had potent inhibitory activity against various Gram-positive bacteria including Enterococcus seriolicida and methicillin-resistant Staphylococcus aureus. (+info)Induction of MDR1 gene expression by anthracycline analogues in a human drug resistant leukaemia cell line. (7/4684)
The effects of 4-demethoxydaunorubicin (idarubicin, IDA) and MX2, a new morpholino-anthracycline, on up-regulation of the MDR1 gene in the low-level multidrug resistant (MDR) cell line CEM/A7R were compared at similar concentrations (IC10, IC50 and IC90) over a short time exposure (4 and 24 h). The chemosensitivity of each drug was determined by a 3-day cell growth inhibition assay. Compared with epirubicin (EPI), IDA and MX2 were 17- and eightfold more effective in the CEM/A7R line respectively. No cross-resistance to 5-FU was seen in the CEM/A7R line. Verapamil (5 microM) and PSC 833 (1 microM), which dramatically reversed resistance to EPI in the CEM/A7R line, had no sensitizing effect on the resistance of this line to MX2, but slightly decreased resistance to IDA. The sensitivity to 5-FU was unchanged by these modulators. The induction of MDR1 mRNA expression by IDA, MX2 and 5-FU was analysed by Northern blotting and semiquantitatively assessed by scanning Northern blots on a phosphorimager. The relative level of MDR1 expression was expressed as a ratio of MDR1 mRNA to the internal RNA control glyceraldehyde-3-phosphate dehydrogenase (GAPDH). IDA, MX2 and 5-FU differentially up-regulated MDR1 mRNA in the CEM/A7R line in a dose-dependent manner. Both IDA and MX2 induced MDR1 expression within 4 h. 5-FU up-regulated MDR1 expression only when drug exposure was prolonged to 24 h. Based on MRK 16 binding, flow cytometric analysis of P-glycoprotein (Pgp) expression paralleled the increase in MDR1 mRNA levels. For the three anthracyclines, the increase in MDR1 expression was stable in cells grown in the absence of drug for more than 3 weeks after drug treatment. The induction of MDR1 expression by 5-FU was transient, associated with a rapid decrease in the increased Pgp levels which returned to baseline 72 h after the removal of 5-FU. This study demonstrates that MDR1 expression can be induced by analogues of anthracyclines not pumped by Pgp, and that this induction appears to be stable despite a 3-week drug-free period. (+info)Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. (8/4684)
We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1-5 at 4-week intervals. Dose was escalated from 2 mg m(-2) day(-1) to 20 mg m(-2) day(-1) in 20 patients. Drug pharmacokinetics was analysed with high performance liquid chromatography with UV-detection. Plasma collected during drug administration was tested in vitro for growth inhibition of a teniposide-resistant small-cell lung cancer (SCLC) cell line. The predominant toxicities were elevated liver transaminases (maximum common toxicity criteria (CTC) grade 4) and serum creatinine (maximum CTC grade 2). These showed only a limited increase with increasing doses, often recovered during drug administration and were fully reversible. Duration of elevated alanine-amino transferase (ALT) was dose-limiting in one patient at 20 mg m(-2). Other frequent toxicities were grade 1-2 nausea/vomiting, fever and mild fatigue. Mean fostriecin plasma half-life was 0.36 h (initial; 95% CI, 0-0.76 h) and 1.51 h (terminal; 95% CI, 0.41-2.61 h). A metabolite, most probably dephosphorylated fostriecin, was detected in plasma and urine. No tumour responses were observed, but the plasma concentrations reached in the patients were insufficient to induce significant growth inhibition in vitro. The maximum tolerated dose (MTD) has not been reached, because drug supply was stopped at the 20 mg m(-2) dose level. However, further escalation seems possible and is warranted to achieve potentially effective drug levels. Fostriecin has a short plasma half-life and longer duration of infusion should be considered. (+info)
Antitumour antibiotic | Article about Antitumour antibiotic by The Free Dictionary
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Effect of Association of Anticancer Antibiotics Upon Chromatin Structure
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Pirarubicin
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Rebeccamycin
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Plicamycin
... (INN, also known as mithramycin; trade name Mithracin) is an antineoplastic antibiotic produced by Streptomyces ... Majee, Sangita; Chakrabarti, Abhijit (1999). "Membrane interaction of an antitumor antibiotic, mithramycin, with anionic ...
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Bleomycin is an antineoplastic antibiotic drug isolated in 1966 from the actinomycete Streptomyces verticillus. Bleomycin forms ...
Bohemic acid
"The Toxicologic Evaluation of Marcellomycin-An Antineoplastic Anthracycline Antibiotic". Drug and Chemical Toxicology. 6 (1): ... Most of those components are antitumor agents and anthracycline antibiotics active against Gram-positive bacteria. Bohemic acid ... Chromatographical separation, in addition to the antibiotics pyrromycin and cinerubin A and B, reveals several individual ... The suffix -mycin is conventionally added to indicate antibiotics derived from actinobacteria or fungi. The individual ...
Drug resistance
... resulting in antibiotic resistance. Furthermore there is mounting concern over the abuse of antibiotics in the farming of ... Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in curing a ... there is a possibility that they might replace novel antibiotics. Antibiotic resistance Fecal bacteriotherapy Mass drug ... Bacteria are capable of not only altering the enzyme targeted by antibiotics, but also by the use of enzymes to modify the ...
Neuritis
Broad categories of medications associated with toxic effects on nerves include: antineoplastic agents, antibiotics, ... While antibiotics are effective at eradicating the bacterium, neurological sequelae of infection must be treated with ... While commonly self-limiting, treatment with antibiotics may hasten resolution of symptoms. Diphtheria, a once common childhood ...
Iatrogenesis
The evolution of antibiotic resistance in bacteria is iatrogenic as well. Bacterial strains resistant to antibiotics have ... Alkylating antineoplastic agents, for example, cause DNA damage, which is more harmful to cancer cells than regular cells. ... Antiseptics, anesthesia, antibiotics, better surgical techniques, evidence-based protocols and best practices continue to be ... Finland M (1979). "Emergence of antibiotic resistance in hospitals, 1935-1975". Rev. Infect. Dis. 1 (1): 4-22. doi:10.1093/ ...
Drug pollution
Antibiotics are widely produced and consumed to treat bacterial and fungal diseases. Since antibiotics are only partially ... Antineoplastic drugs are employed during chemotherapy all over the world. They pollute water courses and have 'mutagenic, ... There is an urgent push to eradicate antibiotics from the environment because they could cause a generation of antibiotics ... Antibiotics were found to reduce growth in algae, aquatic plants and environmental bacteria. Drug pollution still reminds to be ...
Kerria lacca
A recent study has shown that the anthraquinone component of lac dye also possess antineoplastic or anticancer effects. It is ... including antibiotic, antiviral, antifeedant effect. ... 2016). "Lac dye as a potential anti-neoplastic agent". Journal ...
Ribosome
A noteworthy counterexample, however, includes the antineoplastic antibiotic chloramphenicol, which successfully inhibits ... The same of mitochondria cannot be said of chloroplasts, where antibiotic resistance in ribosomal proteins is a trait to be ... Due to the differences in their structures, the bacterial 70S ribosomes are vulnerable to these antibiotics while the ... The differences in structure allow some antibiotics to kill bacteria by inhibiting their ribosomes, while leaving human ...
Nijmegen breakage syndrome
Prophylactic antibiotics are considered to prevent urinary tract infections as those with NBS often have congenital kidney ... In the treatment of malignancies, radiation therapy, alkylating antineoplastic agents, and epipodophyllotoxins are not used, ...
Philip J. Wyatt
They are also used to monitor smog and fly ash, and identify effective antibiotics to counter bacterial infections. "Get into a ... and monitoring for possible toxicity of AZT and antineoplastic drugs in patients. Nobel prize winner Robert H. Grubbs uses them ...
Nanoparticles for drug delivery to the brain
Antibiotics, antineoplastic agents, and a variety of CNS-active drugs, especially neuropeptides, are a few examples of ...
EPOCH (chemotherapy)
... an alkylating antineoplastic agent; Hydroxydaunorubicin, also known as doxorubicin: an anthracycline antibiotic that is able to ... This regimen requires the use of prophylactic antibiotics to prevent infectious complications, as well as the use of colony- ...
Sp1 transcription factor
Plicamycin, an antineoplastic antibiotic produced by Streptomyces plicatus, and Withaferin A, a steroidal lactone from Withania ...
Diarrhea
The classes of medications that are known to cause diarrhea are laxatives, antacids, heartburn medications, antibiotics, anti- ... Antibiotics can also cause diarrhea, and antibiotic-associated diarrhea is the most common adverse effect of treatment with ... In resource-poor countries, treatment with antibiotics may be beneficial. However, some bacteria are developing antibiotic ... Antibiotics, while rarely used, may be recommended in a few cases such as those who have bloody diarrhea and a high fever, ...
Azaserine
... is a naturally occurring serine derivative diazo compound with antineoplastic and antibiotic properties deriving from ...
Duocarmycin
Bizelesin is antineoplastic antibiotic which binds to the minor groove of DNA and induces interstrand cross-linking of DNA, ... a new antitumor antibiotic from Streptomyces". The Journal of Antibiotics. 41 (12): 1915-7. doi:10.7164/antibiotics.41.1915. ... They are notable for their extreme cytotoxicity and thus represent a class of exceptionally potent antitumour antibiotics. As ... represent a new class of highly potent antineoplastic compounds. The work of Dale L. Boger and others created a better ...
Environmental impact of pharmaceuticals and personal care products
Are the levels of antibiotics in the aquatic environment sufficient to promote antibiotic resistance? What is the effect of ... antineoplastics, and diagnostic contrast media.[2] Personal care products have four classes: fragrances, preservatives, ... Moreover, antibiotic resistant bacteria may also remain in sewage sludge and enter the food chain if the sludge is not ... It has also been proven that at even sub-inhibitory concentrations (e.g., one-fourth of the MIC), several antibiotics are able ...
Topoisomerase inhibitor
Bush, Karen (December 2010). "The coming of age of antibiotics: discovery and therapeutic value: Origins of antibiotic drug ... Chemistry, pharmacology, pharmacokinetics, adverse effects and use as an antineoplastic agent". Pharmacotherapy. 4 (2): 61-73. ... cause streptomyces to produce antibiotics. Quinolones are amongst the most commonly used antibiotics for bacterial infections ... These antibiotics are further divided into two group: actinomycin A and actinomycin B. It was shown that both actinomycin A and ...
Distamycin
... is a polyamide-antibiotic, which acts as a minor groove binder, binding to the small furrow of the double helix. ... Derivates from distamycin are used as alkylating antineoplastic agents to combat tumours. Derivates with fluorophores are used ... Distamycin is a pyrrole-amidine antibiotic and analogous to netropsin and the class of lexitropsins. As opposed to netropsin, ...
List of MeSH codes (D27)
... antineoplastic agents MeSH D27.505.954.248.025 - angiogenesis inhibitors MeSH D27.505.954.248.106 - antibiotics, antineoplastic ... antineoplastic agents, alkylating MeSH D27.505.954.248.169 - antineoplastic agents, hormonal MeSH D27.505.954.248.179 - ... MeSH D27.505.519.124 - alkylating agents MeSH D27.505.519.124.035 - antineoplastic agents, alkylating MeSH D27.505.519.155 - ... antibiotics, antifungal MeSH D27.505.954.122.187 - anti-infective agents, local MeSH D27.505.954.122.237 - anti-infective ...
List of MeSH codes (E02)
... antineoplastic combined chemotherapy protocols MeSH E02.319.162.150 - antibiotic prophylaxis MeSH E02.319.300.253 - delayed- ... antibiotic prophylaxis MeSH E02.319.913.500 - hirudin therapy MeSH E02.365.647.110 - cardiopulmonary resuscitation MeSH E02.365 ... antineoplastic combined chemotherapy protocols MeSH E02.190.044.080 - acupressure MeSH E02.190.044.105 - acupuncture analgesia ... antineoplastic combined chemotherapy protocols MeSH E02.319.310.075 - antiretroviral therapy, highly active MeSH E02.319. ...
Kounis syndrome
Drugs that have been found previously include analgesics such as aspirin and dipyrone, anesthetics, multiple antibiotics, ... anticoagulants such as heparin and Lepirudin, thrombolytics such as TPA, anti-platelet therapy including Clopidogrel, anti- ...
Jiangsu Hengrui Medicine
... cancer-treating antineoplastics, cardiovascular medication, painkillers, antibiotics, and related products. It is the largest ...
Index of oncology articles
... antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - antiretroviral therapy - antisense c-fos - ... aminoglycoside antibiotic - aminolevulinic acid - aminopterin - AML - amonafide - amoxicillin - amphotericin B - ampulla - ... anticancer antibiotic - anticarcinogenic - anticoagulant - anticonvulsant - antidepressant - antiemetic - antiestrogen - ... antithymocyte globulin - antituberculosis - antitumor antibiotic - Antiviral drug - anxiolytic - APC - APC vaccine - APC8015 - ...
Toxic encephalopathy
... anti- biotics, antineoplastic agents, and psychiatric medications. (Lerner, David P et al. Neurol Clin. 2020. Toxin-Induced ...
Index of HIV/AIDS-related articles
... antineoplastic - antiprotozoal - antiretroviral drugs - antisense drugs - antitoxins - Antiviral drug - aphasia - aphthous ... antibiotic - antibodies - antibody-dependent cell-mediated cytotoxicity (ADCC) - antibody-mediated immunity - antifungal ...
Bleomycin
The Journal of Antibiotics. 71: 97-103. doi:10.1038/ja.2017.93. PMID 28831149.. ... Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Romidepsin
doi:10.7164/antibiotics.47.301. PMID 7513682.. *^ Li KW, Wu J, Xing W, Simon JA (July 1996). "Total synthesis of the antitumor ... Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ... doi:10.7164/antibiotics.47.311. PMID 8175483.. *^ Ueda, H.; Manda, T.; Matsumoto, S.; Mukumoto, S.; Nishigaki, F.; Kawamura, I ... doi:10.7164/antibiotics.47.315. PMID 8175484.. *^ Greshock, Thomas J.; Johns, Deidre M.; Noguchi, Yasuo; Williams, Robert M. ( ...
Chemotherapy
Cytotoxic antibiotics[edit]. The cytotoxic antibiotics are a varied group of drugs that have various mechanisms of action. The ... Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. Several classification ... The increased use of antineoplastic agents in veterinary oncology also puts these workers at risk for exposure to these drugs.[ ... Antineoplastic Agents in Encyclopedia of Molecular Pharmacology, 2nd Edition, Volume 1. Eds. Offermanns S and Rosenthal W. ...
Antimetabolite
AntibioticsEdit. Antimetabolites may also be antibiotics, such as sulfanilamide drugs, which inhibit dihydrofolate synthesis in ... Antineoplastic+Antimetabolites at the US National Library of Medicine Medical Subject Headings (MeSH) ... Antitumor antibiotics are a class of antimetabolite drugs that are cell cycle nonspecific. They act by binding with DNA ... Anthracyclines are anti-tumor antibiotics that interfere with enzymes involved in copying DNA during the cell cycle. [4] ...
Drug discovery
Streptomyces isolates have been such a valuable source of antibiotics, that they have been called medicinal molds. The classic ... For certain therapy areas, such as antimicrobials, antineoplastics, antihypertensive and anti-inflammatory drugs, the numbers ... example of an antibiotic discovered as a defense mechanism against another microbe is penicillin in bacterial cultures ...
WHO Model List of Essential Medicines
8 Immunomodulators and antineoplastics *8.1 Immunomodulators for non-malignant disease. *8.2 Antineoplastics and supportive ... 6.2.1 Access group antibiotics. *6.2.2 Watch group antibiotics. *6.2.3 Reserve group antibiotics ... Immunomodulators and antineoplastics[edit]. Immunomodulators for non-malignant disease[edit]. *Adalimumabα[note 59] ...
Proton-pump inhibitor
Candidiasis is known to cause GI symptoms particularly in immunocompromised patients or those receiving steroids or antibiotics ...
Prednisone
"Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...
Photodynamic therapy
... field sterilisation after cancer surgery and for the control of antibiotic-resistant bacteria.[5] ... Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Medication
In the 1930s antibiotics emerged: first sulfa drugs, then penicillin and other antibiotics. Drugs increasingly became "the ... systemic antibiotics, topical antibiotics, hormones, desloughing agents, exudate absorbents, fibrinolytics, proteolytics, ... Antibiotics first arrived on the medical scene in 1932 thanks to Gerhard Domagk;[25] and were coined the "wonder drugs". The ... Management of pneumonia before antibiotics". JAMA. 220 (10): 1341-5. doi:10.1001/jama.1972.03200100053011. PMID 4553966.. ...
Immunosuppressive drug
Other cytotoxic antibiotics are anthracyclines, mitomycin C, bleomycin, mithramycin. Antibodies[edit]. Antibodies are sometimes ... Cytotoxic antibiotics[edit]. Among these, dactinomycin is the most important. It is used in kidney transplantations. ...
Trabectedin
... an antibiotic obtained by fermentation of the bacterium Pseudomonas fluorescens.[7] PharmaMar have entered into an agreement ... Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Cisplatin
Other drugs (such as the aminoglycoside antibiotic class) may also cause ototoxicity, and the administration of this class of ... Cisplatin is in the platinum-based antineoplastic family of medications.[1] It works in part by binding to DNA and inhibiting ... antibiotics in patients receiving cisplatin is generally avoided. The ototoxicity of both the aminoglycosides and cisplatin may ...
Bronchodilator
Some medications, such as seizure and ulcer medications and antibiotics containing erythromycin, can interfere with the way ...
Polyestradiol phosphate
Certain antibiotics (e.g., ampicillin, tetracyclines) may decrease estradiol levels by limiting enterohepatic recirculation of ...
Human tooth
Hypoplasia may also result from antineoplastic therapy. Destruction after development[edit]. Tooth destruction from processes ... Some medications, such as tetracycline antibiotics, may become incorporated into the structure of a tooth, causing intrinsic ...
Crosslinking of DNA
Mitomycin C (MMC) is from a class of antibiotics that are used broadly in chemotherapy, often with gastrointestinal related ... Intracellular chemotherapeutic agents / antineoplastic agents (L01). SPs/MIs. (M phase). Block microtubule assembly. *Vinca ...
Diarrhea
The classes of medications that are known to cause diarrhea are laxatives, antacids, heartburn medications, antibiotics, anti- ... treatment with antibiotics may be beneficial.[82] However, some bacteria are developing antibiotic resistance, particularly ... and antibiotic-associated diarrhea is the most common adverse effect of treatment with general antibiotics. ... While antibiotics are beneficial in certain types of acute diarrhea, they are usually not used except in specific situations.[ ...
Pharmacology
... aminoglycoside antibiotics). Most anti-cancer drugs have a narrow therapeutic margin: toxic side-effects are almost always ...
Silver nanoparticle
See also: Antineoplastic resistance. A major cause for the ineffectiveness of current chemotherapy treatments is multiple drug ... It has been noted that the introduction of silver nano particles has shown to have synergistic activity with common antibiotics ... "Synthesis and effect of silver nanoparticles on the antibacterial activity of different antibiotics against Staphylococcus ...
Fatty acid synthase
Inhibitors of this pathway (FASII) are being investigated as possible antibiotics.[14] ... "Fatty acid synthesis: a potential selective target for antineoplastic therapy". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6379-83 ...
Cold medicine
... medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults". The Cochrane Database of ...
Antiandrogen
AR antagonists have been found much less effective compared to established treatments like benzoyl peroxide and antibiotics.[ ... Hormonal antineoplastic drugs. *Prostate cancer. *Sex hormones. *Transgender and medicine. Hidden categories: *CS1 French- ...
Myxobacteria
Metabolites secreted by Sorangium cellulosum known as epothilones have been noted to have antineoplastic activity. This has led ... Myxobacteria produce a number of biomedically and industrially useful chemicals, such as antibiotics, and export those ... 48 (1): 21-5. doi:10.7164/antibiotics.48.21. PMID 7868385. The Myxobacteria Web Page Schwarmentwicklung und Morphogenese bei ...
Chemotherapy
The cytotoxic antibiotics are a varied group of drugs that have various mechanisms of action. The common theme that they share ... Antineoplastic drugs may also increase the risk of learning disabilities among children of health care workers who are exposed ... In the 1970s, antineoplastic (chemotherapy) drugs were identified as hazardous, and the American Society of Health-System ... A written policy needs to be in place in case of a spill of antineoplastic products. The policy should address the possibility ...
Antineoplastic Antibiotics - Pharmacology - Merck Veterinary Manual
Learn about the veterinary topic of Antineoplastic Antibiotics. Find specific details on this topic and related topics from the ... The anthracycline antibiotics, particularly doxorubicin, have become important antineoplastic antibiotics. These drugs ... The antineoplastic antibiotics are products of Streptomyces. The important drugs in this group include actinomycin D ( ... Actinomycin A was the first Streptomyces antibiotic isolated and was followed by related antibiotics, including actinomycin D. ...
Fumagillin | ā„99%(HPLC) | Selleck | Antineoplastic and Immunosuppressive Antibiotics
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... used as an antibiotic to treat microsporidiosis. Quality confirmed by NMR & HPLC. See customer reviews, validations & product ... Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to ... Fumagillin is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to ... Antineoplastic and Immunosuppressive Antibiotics. *Selection Antibiotics for Transfected Cell. *Antibiotics for Mammalian Cell ...
Staurosporine | ā„99%(HPLC) | Selleck | Antineoplastic and Immunosuppressive Antibiotics inhibitor
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Antineoplastic antibiotic | definition of antineoplastic antibiotic by Medical dictionary
What is antineoplastic antibiotic? Meaning of antineoplastic antibiotic medical term. What does antineoplastic antibiotic mean? ... Looking for online definition of antineoplastic antibiotic in the Medical Dictionary? antineoplastic antibiotic explanation ... antineoplastic antibiotic. Also found in: Dictionary, Thesaurus, Legal, Encyclopedia. antineoplastic antibiotic. a chemical ... antineoplastic antibiotic. Anticancer antibiotic, antitumor antibiotic Oncology Any of a group of anticancer drugs that block ...
Granulomatosis with Polyangiitis (GPA, formerly Wegener Granulomatosis) Medication: Corticosteroids, Antineoplastics,...
Antibiotics. Class Summary. Trimethoprim-sulfamethoxazole (TMP-SMZ) is recommended for prophylaxis against Pjiroveci pneumonia ... Antineoplastics, Monoclonal Antibody. Class Summary. Rituximab gained FDA approval for GPA in adults in 2011 and for children ... Antineoplastics, Alkylating. Class Summary. These agents have improved the prognosis of GPA. Cyclophosphamide is initiated with ...
Differential Diagnosis: Antineoplastic antibiotic, Multiple skin lesions
Pediatric Non-Hodgkin Lymphoma Medication: Antineoplastics, Other, PD-1/PD-L1 Inhibitors, Corticosteroids, Antibiotics, Other,...
Antineoplastics, Other. Class Summary. Cancer chemotherapy is based on an understanding of tumoral cell growth and on how drugs ... Antibiotics, Other. Class Summary. Therapy should cover all likely pathogens in the context of this clinical setting. ... Antineoplastic agents interfere with cell reproduction. Some agents are cell cycle specific, whereas others (eg, alkylating ... Nystatin is a fungicidal and fungistatic antibiotic obtained from Streptomyces noursei. It is effective against candidal ...
Doxorubicin | drug | Britannica.com
Doxorubicin and mitoxantrone Drug Interactions - Drugs.com
Anthracyline
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Antibiotics, Antineoplastic Agents, ATC:L01DB02
Daunorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction ... Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the ... antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor ...
STREPTOZOTOCIN
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Antibiotics, Antineoplastic Agents, ATC:L01AD04
Global Platinum Antineoplastics Market Highlights - 2015
... , provides the global Platinum Antineoplastics market valuation, ... 2. Platinum Antineoplastics - Marketed Products. 3. Global Platinum Antineoplastics Market Size. 3a. Platinum Antineoplastics ... Table 4: Platinum Antineoplastics - Key Late Stage Pipeline, 2015. Figure 1: Global Platinum Antineoplastics Market Size ($), ... 6. Platinum Antineoplastics - Key Late Stage Pipeline. 7. Research Methodology. Table 1: Platinum Antineoplastics: Marketed ...
Antineoplastic antibiotic synonyms, antineoplastic antibiotic antonyms - FreeThesaurus.com
Antonyms for antineoplastic antibiotic. 7 words related to antineoplastic antibiotic: antibiotic, antibiotic drug, ... antineoplastic, antineoplastic drug, cancer drug, Mithracin, mithramycin. What are synonyms for antineoplastic antibiotic? ... Words related to antineoplastic antibiotic. an antibiotic drug used as an antineoplastic in chemotherapy. Related Words. * ... antineoplastic antibiotic,type:0,children:[{name:antibiotic,type:4},{name:antibiotic drug,type:4},{name: ...
Precio augmentin 400 - Antibiotics/antineoplastics
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Antibiotics - Therapeutic Classfication
View list of generic drugs that are Therapeutically classified under Antibiotics. Find related prescribing information and ... antineoplastic antibiotic. Generic Name(S). Strength. Dosage Form. ICD Code. Plicamycin 2500 mcg. Injection. Y43.3. ... Antibiotics - Drugs. On Medindia find the complete list of Antibiotics drugs with their available forms and strength. More ... Bacteriostatic Antibiotic. Generic Name(S). Strength. Dosage Form. ICD Code. Fusidic acid 20mg/1gm, 2%/10gm. Cream, Ointment. ...
Bystolic side effects eyes - Antibiotics/antineoplastics
Learn the can eurax cream be bought over the counter secrets that will make yours come out perfect every time. A: Feeling tired may also aciclovir 800 mg comprimidos precio be a sign of low blood pressure, so aciclovir 200 mg tabletten dosierung the. Along with its needed effects, olmesartan (the active zovirax tablets prescription ingredient contained in Benicar) may is bentyl 20 mg a narcotic cause some unwanted effects. Lisinopril does list fatigue as a side effect experienced by at least 1 percent of patients during the study of the medication. Check with your doctor immediately digoxin toxicity aafp if any of the bystolic side effects eyes following side effects occur while taking amlodipine / benazepril. This eMedTV article lists common side effects seen with the drug, rare side effects, and bystolic side effects eyes side effects that you should report immediately to kamagra 100mg tablets your healthcare provider Note: Although not all of these side effects may occur, if they do occur ...
Exam III Antineoplastic Flashcards by Sel M | Brainscape
Study Exam III Antineoplastic flashcards from Sel M ... alkylating antibiotic; cell-cycle nonspecific, although most ... MOST ANTINEOPLASTIC DRUGS TARGET DIVIDING CELLS -SMALL RAPIDLY DIVIDING CELLS RESPOND BEST TO CHEMO. -NORMAL CELLS ALSO RAPIDLY ... Antibiotics: -Cytotoxins **bind with ________ to inhibit _____. -Attack cells in what 2 phases?. -Most effective for _____ ___ ...
Anti-Neoplastic Pharmaceutical Agents Market Estimated to Expand at a Robust CAGR over 2026 | Feb 25, 2019 - ReleaseWire
Segmentation by type of anti-neoplastic pharmaceutical agents,. Alkylating Agents. Antimetabolites. Antitumor Antibiotics. ... Anti-Neoplastic Pharmaceutical Agents Market: Key Players. Some of the key players in manufacturing of anti-neoplastic ... The global anti-neoplastic pharmaceutical agents market is segmented based on type of cancer, anti-neoplastic pharmaceutical ... Anti-neoplastic agents do not get stabilized in one part of the body, however they travel through body and help in destruction ...
NIOSHTIC-2 Publications Search - 20043812 - NIOSH Health and Safety Practices Survey of Healthcare Workers: training and...
... antineoplastic drugs, anesthetic gases, high level disinfectants, surgical smoke, aerosolized medications (pentamidine, ... Chemical-specific safe handling training was lowest for aerosolized antibiotics (52%, n=316), and surgical smoke (57%, n=4,747 ... antineoplastic drugs, anesthetic gases, high level disinfectants, surgical smoke, aerosolized medications (pentamidine, ... Antibiotics; Smoke-inhalation; Surgery; Professional-workers; Medical-personnel; Toxic-gases; Toxic-materials; Toxic-vapors; ...
Chemotherapeutic agents have different specific classifications. The following medications are antineoplastic antibiotics...
The following medications are antineoplastic antibiotics except:. A. Doxorubicin (Adriamycin). B. Fluorouracil (Adrucil). C. ... The following medications are antineoplastic antibiotics except:. Chemotherapeutic agents have different specific ... The following medications are antineoplastic antibiotics except: ...
Bleomycin A5 hydrochloride (CAS 55658-47-4) 90% purity (ab142406) |Abcam
China Antibiotics,Analgesic and Antipyretic,Antiparasitic Drugs,Antineoplastic,Digestive System Drugs,Vitamins,Manufacturer and...
Antibiotic food preservation - definition of antibiotic food preservation by The Free Dictionary
antibiotic food preservation synonyms, antibiotic food preservation pronunciation, antibiotic food preservation translation, ... English dictionary definition of antibiotic food preservation. n. A substance, such as penicillin or erythromycin, produced by ... antineoplastic antibiotic - an antibiotic drug used as an antineoplastic in chemotherapy. Azactam, aztreonam - an antibiotic ( ... antibiotic. [ĖƦntibaÉŖĖÉtÉŖk]. adj ā antibiotique. n ā antibiotique m. to be on antibiotics ā ĆŖtre sous antibiotiques. to take ...
Ć-lactam antibiotic - definition of Ć-lactam antibiotic by The Free Dictionary
Ć-lactam antibiotic synonyms, Ć-lactam antibiotic pronunciation, Ć-lactam antibiotic translation, English dictionary definition ... of Ć-lactam antibiotic. n. A substance, such as penicillin or erythromycin, produced by or derived from certain microorganisms ... antineoplastic antibiotic - an antibiotic drug used as an antineoplastic in chemotherapy. Azactam, aztreonam - an antibiotic ( ... antibiotic. (redirected from Ć-lactam antibiotic). Also found in: Thesaurus, Medical, Legal, Encyclopedia. anĀ·tiĀ·biĀ·otĀ·ic. (Änā² ...
Doxorubicin - LiverTox - NCBI Bookshelf
... idarubicin and valrubicin are structurally related cytotoxic antineoplastic antibiotics used in the therapy of several forms of ... Drug Class: Antineoplastic Agents. Other Drugs in the Subclass, Antibiotics, Cytotoxic: Bleomycin, Dactinomycin, Daunorubicin, ... including 2 attributed to antineoplastic agents, 1 to melphalan and 1 to gemtuzumab, but none to a cytotoxic antibiotic such as ... Doxorubicin, epirubicin, idarubicin and valrubicin are structurally related cytotoxic antineoplastic antibiotics used in the ...
Anthracycline drug targeting: cytoplasmic versus nuclear--a fork in the road. - PubMed - NCBI
daunorubicin (CHEBI:41977)
via carbohydrate-containing antibiotic ). Application(s):. antineoplastic agent A substance that inhibits or prevents the ... daunorubicin (CHEBI:41977) is a aminoglycoside antibiotic (CHEBI:22507) daunorubicin (CHEBI:41977) is a anthracycline (CHEBI: ... daunorubicin (CHEBI:41977) has role antineoplastic agent (CHEBI:35610) daunorubicin (CHEBI:41977) has role bacterial metabolite ...
Antibiotics - Structure, Properties, uses, Synthesis, Assay, Storage, Dosage forms, Dose | Synthesis and Drug Profile |...
DoxorubicinDaunorubicinInhibitorsAgentsAnthracycline antineoplastic antibioticChemotherapyAntitumor AntibioticsAntifungalBleomycinStreptomycesInhibits the growthIdarubicinAntitumourSemisynthetic antibioticsDactinomycinTumorsAminoglycosideDisinfectantsBacteriaCompoundsInjectionCytotoxic drugsCisplatinCephalosporinFungiDrugDosageMedicationTissuesToxic
Doxorubicin7
- The anthracycline antibiotics, particularly doxorubicin , have become important antineoplastic antibiotics. (merckvetmanual.com)
- Includes the antineoplastic drugs doxorubicin and daunorubicin. (thefreedictionary.com)
- Doxorubicin, epirubicin, idarubicin and valrubicin are structurally related cytotoxic antineoplastic antibiotics used in the therapy of several forms of lymphoma, leukemia, sarcoma and solid organ cancers. (nih.gov)
- Doxorubicin (dox" oh roo' bi sin), epirubicin (ep" i roo' bi sin), idarubicin (eye" da roo' bi sin) and valrubicin (val roo' bi sin) are cytotoxic, anthracycline antibiotics which are believed to act by intercalating between DNA base pairs and uncoiling the DNA helix, which results in inhibition of DNA synthesis and the normal DNA breaking and resealing action of DNA toposiomerase II. (nih.gov)
- A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. (cancer.gov)
- Some antineoplastic agents, such as cisplatin and doxorubicin, lead to increases in intracellular reactive oxygen species (ROS) that may contribute to their therapeutic effect ( 4 , 5 ). (aacrjournals.org)
- An analogue of the anthracycline antineoplastic antibiotic doxorubicin. (wikipedia.org)
Daunorubicin2
- Daunorubicin is an antineoplastic in the anthracycline class. (pharmacycode.com)
- 4'-Acetoxy N-(Trifluoroacetyl)daunorubicin-13C,d3 6,8,11-Triyl Triacetate is an intermediate in the synthesis of Daunorubicin-13C,d3 (D194502), an anthracycline antibiotic related to the rhodomycins. (trc-canada.com)
Inhibitors1
- Alkylating agents, antimetabolites, and antibiotics have all been considered inhibitors of wound healing. (medscape.com)
Agents26
- Antibiotics that are sufficiently nontoxic to the host are used as chemotherapeutic agents in the treatment of infectious diseases. (thefreedictionary.com)
- Antineoplastic agents interfere with cell reproduction. (medscape.com)
- Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
- What health effects can be caused by exposure to antineoplastic agents? (cdc.gov)
- Who might be exposed to antineoplastic agents in hospitals? (cdc.gov)
- When are workers most likely to be exposed to antineoplastic agents in hospitals? (cdc.gov)
- How can I protect myself from exposure to antineoplastic agents? (cdc.gov)
- More information about antineoplastic agents. (cdc.gov)
- Some of these antineoplastic agents are also being used for other purposes such as the treatment of nonmalignant diseases. (cdc.gov)
- The purpose of this brochure is to -- make you aware of the adverse health effects of antineoplastic agents, -- describe how you can be exposed to these agents, and -- provide and identify control methods and work practices to prevent or reduce your exposure to antineoplastic agents. (cdc.gov)
- If you experience any of these health problems when working with antineoplastic agents, report them to your supervisor or safety officer. (cdc.gov)
- Statistically significant genotoxic effects and genetic damage (for example, increased micronuclei formation and increases in sister chromatid exchange and chromo- somal aberrations) have been reported in hospital phar- macists and nurses exposed to antineoplastic agents. (cdc.gov)
- The adverse health effects associated with antineoplastic agents (cancer chemotherapy drugs, cytotoxic drugs) in cancer patients and some non-cancer patients treated with these drugs are well-documented. (bionity.com)
- The very nature of antineoplastic agents makes them harmful to healthy cells and tissues, as well as the cancerous cells. (bionity.com)
- However, for the healthcare workers that are exposed to antineoplastic agents as part of their work practice, precautions should be taken to eliminate or reduce exposure as much as possible. (bionity.com)
- Pharmacists that prepare these drugs or nurses that may prepare and/or administer them are the two occupational groups with the highest potential exposure to antineoplastic agents. (bionity.com)
- The increased use of antineoplastic agents in veterinary oncology also puts these workers at risk for exposure to these drugs. (bionity.com)
- What is the dermatologic preoperative evaluation and management of antineoplastic and immunosuppressive agents? (medscape.com)
- Many antineoplastic and immunosuppressive agents have been thought to retard wound healing. (medscape.com)
- However, the use of immunosuppressive or antineoplastic agents may predispose the patient to an even greater risk of infection, and physicians may consider the use of prophylactic antibiotics. (medscape.com)
- Pretreatment with vitamin C caused a dose-dependent attenuation of cytotoxicity, as measured by trypan blue exclusion and colony formation after treatment with all antineoplastic agents tested. (aacrjournals.org)
- Vitamin C treatment led to a dose-dependent decrease in apoptosis in cells treated with the antineoplastic agents that was not due to up-regulation of P-glycoprotein or vitamin C retention modulated by antineoplastics. (aacrjournals.org)
- All antineoplastic agents tested caused mitochondrial membrane depolarization that was inhibited by vitamin C. These findings indicate that vitamin C given before mechanistically dissimilar antineoplastic agents antagonizes therapeutic efficacy in a model of human hematopoietic cancers by preserving mitochondrial membrane potential. (aacrjournals.org)
- Conversely, some reports have suggested that vitamin C might potentiate the effects of some antineoplastic agents, such as arsenic trioxide ( 6 , 7 ). (aacrjournals.org)
- Most of those components are antitumor agents and anthracycline antibiotics active against Gram-positive bacteria. (wikipedia.org)
- Nearly all components of bohemic acid are anthracycline antibiotic agents active against Gram-positive bacteria, but not against Gram-negative bacteria, yeasts or fungi. (wikipedia.org)
Anthracycline antineoplastic antibiotic1
- The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. (cancer.gov)
Chemotherapy1
- Bleomycin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. (chemocare.com)
Antitumor Antibiotics1
- Antineoplastics (or "antitumor antibiotics", or "noncovalent DNA-binding drugs", or "cytotoxic antibiotics", see also neoplastics) are drugs that inhibit and combat the development of tumors . (bionity.com)
Antifungal1
- None of them showed antibiotic, antifungal or antitumor activity. (wikipedia.org)
Bleomycin1
- Bleomycin is classified as an "antitumor antibiotic. (chemocare.com)
Streptomyces3
- The antineoplastic antibiotics are products of Streptomyces . (merckvetmanual.com)
- Actinomycin A was the first Streptomyces antibiotic isolated and was followed by related antibiotics, including actinomycin D. Actinomycin D binds with double-stranded DNA and blocks the action of RNA polymerase, which prevents DNA transcription. (merckvetmanual.com)
- Antineoplastic antibiotic obtained from Streptomyces peucetius. (bioportfolio.com)
Inhibits the growth1
- An antibiotic that inhibits the growth and spread of neoplasms or malignant cells. (thefreedictionary.com)
Idarubicin1
- Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds. (cancer.gov)
Antitumour1
- Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. (pharmacycode.com)
Semisynthetic antibiotics1
- are semisynthetic antibiotics, resistant to Ć-lactamase(advantage over penicillins). (brainscape.com)
Dactinomycin1
- Dactinomycin, used in the treatment of Wilms' tumor, testicular carcinoma, choriocarcinoma, rhabdomyosarcoma, and some other sarcomas, exerts its antineoplastic effect by interfering with ribonucleic acid (RNA) synthesis. (thefreedictionary.com)
Tumors2
- Antineoplastics are used only with certain types of tumors. (thefreedictionary.com)
- In treating skin tumors, antineoplastics can be applied locally. (thefreedictionary.com)
Aminoglycoside2
- Examples of target-altering pathogens are Staphylococcus aureus, vancomycin-resistant enterococci and macrolide-resistant Streptococcus, while examples of antibiotic-modifying microbes are Pseudomonas aeruginosa and aminoglycoside-resistant Acinetobacter baumannii. (wikipedia.org)
- Permanent loss may result from aminoglycoside antibiotics, quinine, and antineoplastic drugs. (cdc.gov)
Disinfectants1
- Background: The Health and Safety Practices Survey of Healthcare Workers describes current practices used to minimize chemical exposures and barriers to using recommended personal protective equipment for the following: antineoplastic drugs, anesthetic gases, high level disinfectants, surgical smoke, aerosolized medications (pentamidine, ribavirin, and antibiotics), and chemical sterilants. (cdc.gov)
Bacteria4
- Furthermore there is mounting concern over the abuse of antibiotics in the farming of livestock, which in the European Union alone accounts for three times the volume dispensed to humans - leading to development of super-resistant bacteria. (wikipedia.org)
- Bacteria are capable of not only altering the enzyme targeted by antibiotics, but also by the use of enzymes to modify the antibiotic itself and thus neutralise it. (wikipedia.org)
- Center for Global Development "The overuse of antibacterial cleaning products in the home may be producing strains of multi-antibiotic-resistant bacteria. (wikipedia.org)
- An antibiotic effective against Gram-negative bacteria. (fiqhcouncil.org)
Compounds1
- Most of these compounds have been isolated from natural sources and antibiotics. (pharmacycode.com)
Injection2
- Rocephin ( ceftriaxone sodium ) for Injection is a cephalosporin antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms such as meningitis . (rxlist.com)
- It is possible to increase the effectiveness of the treatment and decrease the toxic effects of the preparation by special injection methods, when the antineoplastic is injected into the vessels that supply the tumor with blood. (thefreedictionary.com)
Cytotoxic drugs1
- Refractory secondary leukemia is more common when such drugs are given in combination with DNA-damaging antineoplastics, when patients have been heavily pretreated with cytotoxic drugs, or when epirubicin dosage has been escalated. (thefreedictionary.com)
Cisplatin1
- On the other hand, noise exposure and cisplatin, an antineoplastic agent, have a significant synergistic interaction with the effect being greatest in the high frequencies. (cdc.gov)
Cephalosporin1
- Rocephin is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or intramuscular administration. (rxlist.com)
Fungi1
- The suffix -mycin is conventionally added to indicate antibiotics derived from actinobacteria or fungi. (wikipedia.org)
Drug4
- Be aware that drug may be given with antibiotics. (thefreedictionary.com)
- The sample may have been biased as many patients receiving treatments frequently associated with drug-induced hyperpigmentation, such as antineoplastic drugs, are diagnosed and treated by other specialties, such as oncologists. (jabfm.org)
- Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in curing a disease or condition. (wikipedia.org)
- Because the drug is so specific, any mutation in these molecules will interfere with or negate its destructive effect, resulting in antibiotic resistance. (wikipedia.org)
Dosage4
- A multiparticulate, pharmaceutical dosage form containing at least one antibiotic which is sparingly wettable with aqueous media or sparingly soluble in aqueous media and a combination of carrageenan and tricalcium phosphate and optionally sucrose ester. (freepatentsonline.com)
- 15. A dosage form according to claim 1, further comprising at least one antibiotic selected from the group consisting of penicillins, cephalosporins and macrolides. (freepatentsonline.com)
- 16. A dosage form according to claim 15, wherein the at least one antibiotic is amoxicillin, clarithromycin, azithromycin (mono- or dihydrate) or cefixim, cefpodoxime or cefpodoxime proxetil. (freepatentsonline.com)
- 20. A dosage form according to claim 19, wherein, at a pH value of 6-7, the antibiotic is released in a quantity of at least 85% within 30 min. (freepatentsonline.com)
Medication1
- This medication is classified as an "anthracyline antitumor antibiotic. (chemocare.com)
Tissues2
- Treatment with antineoplastics is based on the differences between the biochemical properties of normal and tumoral tissues and is directed predominantly toward suppressing the accelerated reproduction of tumoral cells. (thefreedictionary.com)
- Antineoplastics also affect normal tissues when they act on a tumor. (thefreedictionary.com)
Toxic2
- Many antineoplastics are toxic and produce side effects that may or may not be associated with the mechanism of suppressing cell reproduction. (thefreedictionary.com)
- Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. (fiqhcouncil.org)