Ceftriaxone: A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Cefotaxime: Semisynthetic broad-spectrum cephalosporin.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Cephalosporins: A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.Antibiotic Prophylaxis: Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.Meningitis, Pneumococcal: An acute purulent infection of the meninges and subarachnoid space caused by Streptococcus pneumoniae, most prevalent in children and adults over the age of 60. This illness may be associated with OTITIS MEDIA; MASTOIDITIS; SINUSITIS; RESPIRATORY TRACT INFECTIONS; sickle cell disease (ANEMIA, SICKLE CELL); skull fractures; and other disorders. Clinical manifestations include FEVER; HEADACHE; neck stiffness; and somnolence followed by SEIZURES; focal neurologic deficits (notably DEAFNESS); and COMA. (From Miller et al., Merritt's Textbook of Neurology, 9th ed, p111)Cephalosporin Resistance: Non-susceptibility of an organism to the action of the cephalosporins.Drug Resistance, Bacterial: The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Cefixime: A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.beta-Lactams: Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Penicillins: A group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics. (Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1065)Streptococcus pneumoniae: A gram-positive organism found in the upper respiratory tract, inflammatory exudates, and various body fluids of normal and/or diseased humans and, rarely, domestic animals.Penicillin Resistance: Nonsusceptibility of an organism to the action of penicillins.Neisseria gonorrhoeae: A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.Gonorrhea: Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.Bacterial Infections: Infections by bacteria, general or unspecified.Lactams: Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.Cefuroxime: Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, GONORRHEA, and HAEMOPHILUS.Aminoglycosides: Glycosylated compounds in which there is an amino substituent on the glycoside. Some of them are clinically important ANTIBIOTICS.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Gentamicins: A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Drug Resistance, Multiple, Bacterial: The ability of bacteria to resist or to become tolerant to several structurally and functionally distinct drugs simultaneously. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Excitatory Amino Acid Transporter 2: A glutamate plasma membrane transporter protein found in ASTROCYTES and in the LIVER.Meningitis: Inflammation of the coverings of the brain and/or spinal cord, which consist of the PIA MATER; ARACHNOID; and DURA MATER. Infections (viral, bacterial, and fungal) are the most common causes of this condition, but subarachnoid hemorrhage (HEMORRHAGES, SUBARACHNOID), chemical irritation (chemical MENINGITIS), granulomatous conditions, neoplastic conditions (CARCINOMATOUS MENINGITIS), and other inflammatory conditions may produce this syndrome. (From Joynt, Clinical Neurology, 1994, Ch24, p6)beta-Lactamases: Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.Gram-Negative Bacteria: Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Antibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.Penicillin G: A penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-positive bacteria and against gram-negative cocci. It has also been used as an experimental convulsant because of its actions on GAMMA-AMINOBUTYRIC ACID mediated synaptic transmission.Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.Ceftazidime: Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Gram-Positive Bacteria: Bacteria which retain the crystal violet stain when treated by Gram's method.Cefazolin: A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.Chloramphenicol: An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)Drug Utilization: The utilization of drugs as reported in individual hospital studies, FDA studies, marketing, or consumption, etc. This includes drug stockpiling, and patient drug profiles.Erythromycin: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.Macrolides: A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.Meningitis, Haemophilus: Infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.Community-Acquired Infections: Any infection acquired in the community, that is, contrasted with those acquired in a health care facility (CROSS INFECTION). An infection would be classified as community-acquired if the patient had not recently been in a health care facility or been in contact with someone who had been recently in a health care facility.Meningitis, Bacterial: Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.Endocarditis, Bacterial: Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.Netilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.Tetracycline: A naphthacene antibiotic that inhibits AMINO ACYL TRNA binding during protein synthesis.Fluoroquinolones: A group of QUINOLONES with at least one fluorine atom and a piperazinyl group.Serum Bactericidal Test: Method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.beta-Lactam Resistance: Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets.Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.Thienamycins: Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum. Thienamycin and its more stable derivatives are proposed for use in combinations with enzyme inhibitors.Cefotiam: One of the CEPHALOSPORINS that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.Bacterial Proteins: Proteins found in any species of bacterium.Enterobacteriaceae: A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.Sulbactam: A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.Cefoperazone: Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It has been proposed especially against Pseudomonas infections.Injections, Intramuscular: Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.Pneumococcal Infections: Infections with bacteria of the species STREPTOCOCCUS PNEUMONIAE.Doxycycline: A synthetic tetracycline derivative with similar antimicrobial activity.Ceftizoxime: A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed)Penicillin-Binding Proteins: Bacterial proteins that share the property of binding irreversibly to PENICILLINS and other ANTIBACTERIAL AGENTS derived from LACTAMS. The penicillin-binding proteins are primarily enzymes involved in CELL WALL biosynthesis including MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PEPTIDE SYNTHASES; TRANSPEPTIDASES; and HEXOSYLTRANSFERASES.Pseudomonas aeruginosa: A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.Salmonella Infections: Infections with bacteria of the genus SALMONELLA.Imipenem: Semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains. It is stable to beta-lactamases. Clinical studies have demonstrated high efficacy in the treatment of infections of various body systems. Its effectiveness is enhanced when it is administered in combination with CILASTATIN, a renal dipeptidase inhibitor.Colony Count, Microbial: Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.Piperacillin: Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Surgical Wound Infection: Infection occurring at the site of a surgical incision.Trimethoprim-Sulfamethoxazole Combination: This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.Cefonicid: A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.Cross Infection: Any infection which a patient contracts in a health-care institution.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)Typhoid Fever: An acute systemic febrile infection caused by SALMONELLA TYPHI, a serotype of SALMONELLA ENTERICA.Salmonella: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.Skin Diseases, Infectious: Skin diseases caused by bacteria, fungi, parasites, or viruses.Klebsiella: A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary tract and several other types of human infection.Tobramycin: An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.Amikacin: A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.Pneumonia, Pneumococcal: A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.Spectinomycin: An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of gonorrhea.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Cerebrospinal Fluid: A watery fluid that is continuously produced in the CHOROID PLEXUS and circulates around the surface of the BRAIN; SPINAL CORD; and in the CEREBRAL VENTRICLES.Staphylococcal Infections: Infections with bacteria of the genus STAPHYLOCOCCUS.
Antibiotics, such as ceftriaxone and doxycycline. Colitis Proctitis Online Medical dictionary "Proctitis, Proctocolitis, and ...
Ceftriaxone is an antibiotic commonly employed today. Hydrocortisone can sometimes reverse the adrenal insufficiency. Plastic ... from meningococci bacteria in the bloodstream is a medical emergency and requires emergent treatment with adequate antibiotics ...
Ceftriaxone, a third-generation cephalosporin antibiotic, may be as effective as penicillin-based treatment. It is recommended ... Syphilis can be effectively treated with antibiotics. The preferred antibiotic for most cases is benzathine benzylpenicillin ... More research is needed into how much antibiotic to give and when to give it. In 2012, about 0.5% of adults were infected with ... Walker, GJ (2001). "Antibiotics for syphilis diagnosed during pregnancy". The Cochrane Database of Systematic Reviews (3): ...
Initially, broad-spectrum antibiotics are given, such as ceftriaxone. As culture results become available, treatment can be ... Long-term antibiotics may be necessary to completely eradicate the infection. If the condition does not quickly improve with ... However, it is difficult for antibiotics to penetrate to the interior of the mastoid process and so it may not be easy to cure ... If ear infections are treated in a reasonable amount of time, the antibiotics will usually cure the infection and prevent its ...
Treatment if infected is with antibiotics such as: doxycycline, penicillin, or ceftriaxone. Weil's disease and severe pulmonary ... and use of antibiotics increases antibiotics resistance. Pre-exposure prophylaxis may be beneficial for individuals traveling ... The antibiotic doxycycline, when used in an effort to prevent infection among travellers, is of unclear benefit. Vaccines for ... Effective antibiotics include penicillin G, ampicillin, amoxicillin and doxycycline. In more severe cases cefotaxime or ...
Other antibiotics active against Y. enterocolitica include trimethoprim-sulfamethoxasole, fluoroquinolones, ceftriaxone, and ...
Appropriate antibiotics may include ceftriaxone, ciprofloxacin, levofloxacin, or ampicillin/sulbactam. As of 2005, there is ... Pseudomonas has natural resistance to many antibiotics and has been known to acquire resistance to every antibiotic except for ... Empiric antibiotics should take into account both the risk factors a particular individual has for resistant bacteria as well ... Treatment of VAP with a single antibiotic has been reported to result in similar outcomes as with a combination of more than ...
... ceftriaxone and rifampin. Health officials are hesitant in using systemic antibiotics like rifampin. Although they may help in ... Premature use of this antibiotic without further studies (and the use of rifampin to treat sporadic cases) could result in a ... Blood cultures taken before antibiotic administration Serum or urine antigen detection[CDC] H. influenzae biogroup aegyptius is ... treating the BPF clone, more studies should be done before this antibiotic is applied to more cases. ...
Lab tests found it to be resistant to high concentrations of ceftriaxone, as well as most of the other antibiotics tested. ... Due to resistance to penicillins, standard treatment is with the third generation cephalosporin ceftriaxone. Antibiotic ... and may be prevented by antibiotic treatment of the mother before birth and the application of antibiotic eye gel on the eyes ... Antibiotic resistance in gonorrhea has been noted beginning in the 1940s. Gonorrhea was treated with penicillin, but doses had ...
Initial treatment typically include antibiotics such as vancomycin, ceftriaxone, or ceftazidime. Surgery may also be done to ... After a good response to intravenous antibiotics, patients can be switched to oral antibiotics. The duration of oral ... A replacement prosthesis is usually not inserted at the time of removal to allow antibiotics to clear infection of the region. ... Patients that cannot have surgery may try long-term antibiotic therapy in order to suppress the infection. Close follow up with ...
... is an antibiotic useful to treat a number of bacterial infections. This includes otitis media, strep throat, pneumonia ... In the United States it is a second line treatment to ceftriaxone for gonorrhea. It is taken by mouth. Common side effects ... Cefixime is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary ... Cefixime is contraindicated in patients with known sensitivity or allergies to cephalosporin class of antibiotics. As Cefixime ...
As of 2010, injectable ceftriaxone is one of the few effective antibiotics. This is typically given in combination with either ... Resistance has developed to many previously used antibiotics and higher doses of ceftriaxone are occasionally required. ... The silver-based treatment was used until the first antibiotics came into use in the 1940s. The exact time of onset of ... "Antibiotic-resistant gonorrhoea on the rise, new drugs needed". World Health Organization. 7 July 2017. Archived from the ...
... penicillin and cephalosporin Beta-lactam antibiotic products include 16 varieties of API and intermediates. The ... The cephalosporin series includes intermediate 7-ACA, cefazolin sodium, cefazolin acid and ceftriaxone sodium. Meropenem API is ... is one of China's largest producers of bulk antibiotic active pharmaceutical ingredients. CSPC Zhongrun produces both ...
Ceftriaxone, cefotaxime, and ceftazidime have failed even more often, despite the organism's susceptibility to the antibiotic ... Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common ... Beta-lactam antibiotics are typically used to treat a broad spectrum of Gram-positive and Gram-negative bacteria. Beta- ... A broader set of β-lactam antibiotics are susceptible to hydrolysis by these enzymes. An increasing number of ESBLs not of TEM ...
Intravenous antibiotics such as ceftriaxone and possibly vancomycin or clindamycin is then given. Corticosteroids are also ... The antibiotic rifampin may also be used to prevent the disease among those who have been exposed to the disease and are at ... In addition, people should be given antibiotics, such as second- or third-generation cephalosporins, either alone or in ... Zoorob, R; Sidani, MA; Fremont, RD; Kihlberg, C (1 November 2012). "Antibiotic use in acute upper respiratory tract infections ...
Treatment involves a course of antibiotics to cover the appropriate organisms, typically ceftriaxone plus azithromycin. ...
If joint swelling persists or returns, a second round of antibiotics may be considered. Outside of that, a prolonged antibiotic ... Intravenous administration of ceftriaxone is recommended as the first choice in these cases; cefotaxime and doxycycline are ... guided by in vitro antibiotic sensitivities, including tetracycline antibiotics, amoxicillin, cefuroxime axetil, intravenous ... Antibiotics are the primary treatment. The specific approach to their use is dependent on the individual affected and the stage ...
Recommended antibiotics in those who are young and sexually active are ceftriaxone and doxycycline. Among those who are older ... In chronic epididymitis, a four- to six-week course of antibiotics may be prescribed to ensure the complete eradication of any ... antibiotics are used if an infection is suspected. The treatment of choice is often azithromycin and cefixime to cover both ...
Resistance to a number of other previously effective antibiotics is common. Paratyphoid affects about 6 million people a year. ... Major control treatments for paratyphoid fever include ciprofloxacin for ten days, ceftriaxone/cefotaxime for 14 days, or ... With proper testing and diagnosis, the mortality rate falls to less than 1%. Antibiotics such as azithromycin are particularly ... Control requires treatment of antibiotics and vaccines prescribed by a doctor. ...
Treatments were generally unaffordable, costing as much as 15 days wages for a course of the antibiotic ceftriaxone. The public ...
Ceftriaxone, an antibiotic, has been shown to induce/enhance the expression of EAAT2, resulting in reduced glutamate activity. ... Ceftriaxone has been shown to reduce the development and expression of tolerance to opiates and other drugs of abuse. EAAT2 may ... Lee SG, Su ZZ, Emdad L, Gupta P, Sarkar D, Borjabad A, Volsky DJ, Fisher PB (May 2008). "Mechanism of ceftriaxone induction of ... Translational activators of EAAT2/GLT-1, such as ceftriaxone and LDN/OSU-0212320, have been described to have significant ...
... of choice for HACEK organisms in endocarditis is the third generation cephalosporin and β-Lactam antibiotic ceftriaxone. ...
Appropriate antibiotics, such as ceftriaxone, may be given to kill the bacteria but are not necessary in most cases. ... Antibiotic resistance rates are increasing throughout the world, so health care providers should check current recommendations ... In those at high risk or in whom the disease has spread outside the intestines, antibiotics are recommended. Salmonellosis is ... The country eradicated salmonella without vaccines and antibiotics by focusing on eliminating the infection from "breeder ...
Antibiotic sensitivity can also be tested with these cultures, making them useful in the selection of antibiotic treatment. ... a dose of intravenous ceftriaxone is often prescribed. Trimethoprim/sulfamethoxazole or amoxicillin/clavulanate orally for 14 ... a short course of antibiotics may be taken as soon as symptoms begin or long-term antibiotics may be used as a preventative ... taking a short course of antibiotics when each infection occurs is associated with the lowest antibiotic use. A prolonged ...
It has also been shown to be susceptible to ampicillin & ceftriaxone. The many home remedies or natural treatments for urinary ... by testing for susceptibility to the antibiotic novobiocin. S. saprophyticus is novobiocin-resistant, whereas S. epidermidis is ...
Antibiotic ointment is typically applied to the newborn's eyes within 1 hour of birth as prevention against gonococcal ... Single injection of ceftriaxone IM or IV should be given to infants born to mothers with untreated gonococcal infection. ... Antibiotic ointment is typically applied to the newborn's eyes within 1 hour of birth as prevention against gonococcal ... Other bacterial ophthalmia neonatorum should be treated by broad spectrum antibiotics drops and ointment for two weeks. ...
Ceftriaxone Sodium injection, Ceftriaxone Injection manufacturer, Ceftriaxone Sodium injection suppliers, Ceftriaxone Sodium ... Ceftriaxone is contraindicated in patients with known hypersensitivity to beta-lactam antibiotics. In patients hypersensitive ... Ceftriaxone Sodium injection. Home › Pharmaceutical Medicine › Human Medicine › Pharmaceutical Injection › Ceftriaxone Sodium ... We deal in the Ceftriaxone Sodium injection, which is an incredible broad-spectrum bactericidal cephalosporin antibiotic. It is ...
The strains of Neisseria gonorrhoeae are fast becoming resisted to Ceftriaxone and cefixime, which are very effective control ... These developments show promise being a means to counteract the bacterial effectiveness against existing antibiotics. The ... The strains of Neisseria gonorrhoeae are fast becoming resisted to Ceftriaxone and cefixime, which are very effective control ... These developments show promise being a means to counteract the bacterial effectiveness against existing antibiotics. The ...
Aggregated GC have a higher survival rate when treated with ceftriaxone than non-aggregated GC, with bacteria in the core of ... This study demonstrates that the aggregation of N. gonorrhoeae can reduce the susceptibility to antibiotics, and suggests that ... We examined the effect of aggregation on GC antibiotic susceptibility and the relationship between bacterial aggregate size and ... Inhibiting aggregation may be a potential way of increasing the efficacy of ceftriaxone treatment, consequently reducing ...
Long-term antibiotics after ceftriaxone did not improve quality of life in persistent Lyme disease John Meyerhoff, MD ... Meyerhoff J. Long-term antibiotics after ceftriaxone did not improve quality of life in persistent Lyme disease. Ann Intern Med ... In patients with persistent symptoms of Lyme disease, does longer-term antibiotic treatment after ceftriaxone improve health- ... Duration of Antibiotic Therapy for Early Lyme Disease: A Randomized, Double-Blind, Placebo-Controlled Trial Annals of Internal ...
The antibiotic ceftriaxone was recently reported to induce excitatory amin … ... Induction of Nrf2 and xCT Are Involved in the Action of the Neuroprotective Antibiotic Ceftriaxone in Vitro Jan Lewerenz 1 , ... Induction of Nrf2 and xCT Are Involved in the Action of the Neuroprotective Antibiotic Ceftriaxone in Vitro Jan Lewerenz et al. ... The antibiotic ceftriaxone was recently reported to induce excitatory amino acid transporter 2 and to prolong the survival of ...
Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic ... Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic ... Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic ... Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic ...
... and neurologic impairment after standard 2-4 week antibiotic treatment. While the causes for this post-treatment Lyme disease ... We found that ceftriaxone pulse dosing could only eradicate planktonic log phase B. burgdorferi spirochetal forms and round ... We found that ceftriaxone pulse dosing could only eradicate planktonic log phase B. burgdorferi spirochetal forms and round ... Moreover, we found that not all drugs are suitable for pulse dosing, with bactericidal drugs ceftriaxone and cefuroxime being ...
Ask questions and get answers about Ceftriaxone. Our support group helps people share their own experience. 17 questions, 23 ... 17, 2016 - Antibiotics taken orally are as effective - and doubtless much more welcome - than intravenous antibiotics for ... Ceftriaxone Patient Information at Drugs.com. *Ceftriaxone Information for Consumers. *Ceftriaxone Information for Healthcare ... Ceftriaxone - I have been prescribed a six week course of therapy via PICC line to treat an?. Posted 4 Apr 2017 • 1 answer ...
No association between resistance mutations, empiric antibiotic, and mortality in ceftriaxone-resistant Escherichia coli and ... No association between resistance mutations, empiric antibiotic, and mortality in ceftriaxone-resistant Escherichia coli and ... empiric antibiotic, and mortality in ceftriaxone-resistant Escherichia coli and Klebsiella pneumoniae bacteremia. Scientific ... A post-hoc analysis on 123 patients with ceftriaxone-resistant Escherichia coli and Klebsiella pneumoniae bacteremia treated ...
Classification: HYDROLASE/Antibiotic. *Organism(s): Mycobacterium tuberculosis H37Rv. *Expression System: Escherichia coli ... Ceftriaxone. C18 H18 N8 O7 S3. VAAUVRVFOQPIGI-TYHRLYECSA-N. Ligand Interaction. ... Beta-Lactamase, mixed with Ceftriaxone, needles crystal form, 500ms. *DOI: 10.2210/pdb6B6E/pdb ...
Ceftriaxone Injection: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Antibiotics such as ceftriaxone injection will not work for colds, flu, or other viral infections.Using antibiotics when they ... tell your doctor and pharmacist if you are allergic to ceftriaxone; carbapenem antibiotics; other cephalosporin antibiotics ... Ceftriaxone injection is in a class of medications called cephalosporin antibiotics. It works by killing bacteria. ...
Ceftriaxone official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, ... Ceftriaxone for injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or ... Ceftriaxone showed no potential for mutagenic activity in these studies.. Impairment of Fertility Ceftriaxone produced no ... Ceftriaxone concentrations in urine are shown in Table 2.. Table 2. Urinary Concentrations of Ceftriaxone After Single Dose ...
We identified the isolate and nucleic acid amplification testing (NAAT) specimen as the ceftriaxone-resistant strain multilocus ... a case of Neisseria gonorrhoeae associated with ceftriaxone treatment failure was identified in Alberta, Canada. ... Phenotypic and genetic antibiotic susceptibility testing for ceftriaxone-resistant Neisseria gonorrhoeae isolate, Alberta, ... Lefebvre B, Martin I, Demczuk W, Deshaies L, Michaud S, Labbé A-C, et al. Ceftriaxone-Resistant Neisseria gonorrhoeae, Canada, ...
Ceftriaxone (Rocephin). Ceftriaxone is a third-generation cephalosporin with broad-spectrum gram-negative activity; it has ... The Role of Antibiotics in Inflammatory Bowel Disease. Curr Treat Options Gastroenterol. 2005 Jun. 8(3):223-228. [Medline]. ... Antibiotics. Empiric antimicrobial therapy must be comprehensive and should cover all likely pathogens in the context of the ... Which medications in the drug class Antibiotics are used in the treatment of Colitis?. Updated: Oct 02, 2017 ...
Ceftriaxone Sodium is supplied as a dry powder form equivalent to either 1 g or 2 g of ceftriaxone. Ceftriaxone Sodium is a ... potential of Ceftriaxone Sodium is similar to that of other cephalosporins.. Ceftriaxone is excreted via both biliary and renal ... The drug chamber is filled with ceftriaxone sodium, a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for ... Ceftriaxone Sodium contains approximately 83 mg (3.6 mEq) of sodium per gram of ceftriaxone activity.. The diluent chamber ...
... ceftriaxone) is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria i ... Anti Biotic * Anti Allergy * Liver Disease * Anti Cancer * Diabetese * Hormones * Skin Care * Cardiovascular * Muscle Relaxant ... Rocephin (ceftriaxone) is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. Rocephin ... Rocephin (ceftriaxone) is a cephalosporin (SEF a low spor in) antibiotic. It works by fighting bacteria in your body. ...
Ceftriaxone is a cephalosporin antibiotic and was administered intravenously via a central venous catheter twice a day. ... Ceftriaxone-a semi-synthetic, third generation cephalosporin antibiotic-may increase the level of a protein that decreases ... Active Comparator: Ceftriaxone Two thirds of participants were assigned to 4 grams of ceftriaxone per day. This is a blinded ... Drug: ceftriaxone Participants will be randomly assigned to receive treatment with ceftriaxone or placebo for at least 12 ...
Ceftriaxone for Injection, USP is a sterile, semisynthetic, broad-spectrum cephalosporin antibiotic for intravenous or ... CEFTRIAXONE FOR INJECTION, USP. 1 gram/Vial EQUIVALENT TO 1 GRAM CEFTRIAXONE. FOR IV OR IM USE Single Dose Vial. PROTECT FROM ... CEFTRIAXONE FOR INJECTION, USP. 2 grams/Vial EQUIVALENT TO 2 GRAMS CEFTRIAXONE. FOR IV OR IM USE Single Dose Vial. PROTECT FROM ... CEFTRIAXONE FOR INJECTION, USP. 250 mg/Vial. EQUIVALENT TO 250 MG CEFTRIAXONE. FOR IV OR IM USE Single Dose Vial. PROTECT FROM ...
Mainstay of treatment for SBP is use of proper antibiotics. Although, several antibiotics including cefotaxime, ceftriaxone, or ... Mainstay of treatment for SBP is use of proper antibiotics. Although, several antibiotics including cefotaxime, ceftriaxone, or ... Drug Information available for: Cefotaxime Ceftriaxone Ceftriaxone sodium Ciprofloxacin Ciprofloxacin hydrochloride U.S. FDA ... Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of SBP in Patients With LC. The safety ...
Ceftriaxone (Rocephin). *View full drug information. Third-generation cephalosporin with broad-spectrum, gram-negative activity ... Antibiotics. Class Summary. Therapy must cover all likely pathogens in the context of this clinical setting. Antibiotic ...
Ceftriaxone (Rocephin). *View full drug information. Third-generation cephalosporin with broad-spectrum, gram-negative activity ... Antibiotics. Class Summary. Therapy must cover all likely pathogens in the context of the clinical setting. ... Aminoglycoside antibiotic for gram-negative coverage. Used in combination with both an agent against gram-positive organisms ... Administering prophylactic antibiotics, while not decisively validated by scientific studies, should be a consideration. ...
Find patient medical information for Ceftriaxone Injection on WebMD including its uses, side effects and safety, interactions, ... Before using ceftriaxone, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as ... Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such ... ceftriaxone 2 gram solution for injection. color. light yellow. shape. No data.. imprint. No data.. This medicine is a light ...
Antibiotic therapy was continued, and because of the failure of medical therapy, a mastoidectomy was planned for treatment day ... The patient was admitted to the hospital, and treatment with 2 g intravenous ceftriaxone once daily was initiated. Ceftriaxone ... ceftriaxone disodium salt and a vial of ceftriaxone sodium BP. The sample contained only 0.455 g of the drug, not 1 g as stated ... Second, it is not known whether the antibiotic that was tested came from the same lot that was used to treat this patient. ...
Ceftriaxone-metronidazole. Home / Ceftriaxone-metronidazole. As an alternative to Cefuroxime-Metronidazole, the combination of ... dosage: Ceftriaxone 2000mg 1dd (IV) + Metronidazole 500mg 3dd (IV). *dosage for children (,18jr): *Ceftriaxone 100mg/kg/day, ... total number of doses: in arm A (48h): 2 doses Ceftriaxone and 6 doses Metronidazole, in arm B (5d): 5 doses Ceftriaxone and 15 ... APPIC: Antibiotics following aPPendectomy In Complex appendicitis. Short versus standard course postoperative antibiotic ...
... whether broad-spectrum antibiotics, such as meropenem, influence the dissemination of multidrug-resistant (MDR) bacteria during ... whether broad-spectrum antibiotics, such as meropenem, influence the dissemination of multidrug-resistant (MDR) bacteria during ... it has been suggested that antibiotic prophylaxis may be beneficial in certain clinical conditions such as acute pancreatitis ( ... it has been suggested that antibiotic prophylaxis may be beneficial in certain clinical conditions such as acute pancreatitis ( ...
  • What conditions does Ceftriaxone Vial treat? (webmd.com)
  • To determine whether the patient's treatment failure and subsequent death might be related to the ceftriaxone product administered, a sealed vial similar to the one administered to the patient was analyzed at the University of Ottawa, Canada, and was found to contain only 0.455 g of the drug, not 1 g as stated by the manufacturer. (cdc.gov)
  • Each vial contains an almost white or yellowish-orange crystalline powder equivalent to ceftriaxone 1 g. (medbroadcast.com)
  • Each vial contains white to pale yellow powder equivalent to ceftriaxone 250 mg. (medbroadcast.com)
  • One dose of ceftriaxone was as effective as ampicillin/ cloxacillin in preventing post-caesarean section complications and is easier to administer. (who.int)
  • The combination of ceftriaxone with trovafloxacin considerably improved the killing rates (−0.67 ± 0.16 Δlog 10 CFU/ml · h) and was slightly superior to ceftriaxone with vancomycin (killing rate, −0.53 ± 0.22 Δlog 10 CFU/ml · h), the regimen most commonly used in clinical practice. (asm.org)
  • Our aim was to evaluate the clinical profile, treatment, and outcome of ceftriaxone-associated postrenal acute renal failure (PARF) in children. (aappublications.org)
  • 1 Clinical studies have demonstrated that ceftriaxone can cause biliary pseudolithiasis, 2 , 3 nephrolithiasis, 4 - 7 and bladder sludge, 8 especially in children. (aappublications.org)
  • During the late 1990s, the FDA suddenly decided to require "better" statistical power for clinical trials of antibiotics by requiring companiesto enroll about twice as many subjects, making trials much lengthier and prohibitively expensive - yet no more medically relevant. (nypost.com)
  • After countless meetings with the FDA over a three-year period, he finally convinced the agency to postpone its new clinical requirements so that Wyeth could continue the development of its antibiotic Tigacyl, which would have otherwise been dropped. (nypost.com)
  • A previous study showed that four rounds of ceftriaxone pulse dosing treatment eradicated B. burgdorferi persisters in vitro using a relatively young late log phase culture (5 day old). (frontiersin.org)
  • In vitro, synergy was demonstrated between ceftriaxone and trovafloxacin by the checkerboard method (fractional inhibitory concentration index, 0.5) and by time-killing assays over 8 h. (asm.org)
  • We evaluated the in vitro microbiological efficacy of a generic ceftriaxone product against several clinically significant organisms collected from sterile sites. (scielo.org.za)
  • Participants will be randomly assigned to receive treatment with ceftriaxone (2/3 of participants) or placebo (1/3 of participants) for at least 12 months. (clinicaltrials.gov)
  • Due to precipitation of ceftriaxone in bile, biliary sludging, gallstones, and cholecystitis are also possible, if less common.It should not be used in newborns due to the risks of bilirubin encephalopathy and ceftriaxone-calcium precipitation. (made-in-china.com)
  • Be aware that drug mustn't be given with or within 48 hours of calcium-containing I.V. solutions, including calcium-containing continuous infusions such as parenteral nutrition, because of risk of precipitation of ceftriaxone calcium salt (particularly in neonates). (thefreedictionary.com)
  • b iliary penetration of antibiotics is not the issue- no antibiotic penetrates an obstructed biliary tract for at least 1 day following relief of obstruction. (aimed.net.au)
  • Approximately 33% to 67% of ceftriaxone is excreted unmetabolized in the urine, whereas the remainder is excreted through biliary elimination. (aappublications.org)
  • In this paper we present an interesting case report of a 28-day-old neonate with spontaneous severe epidural hematoma who developed biliary pseudolithiasis related to the use of ceftriaxone. (dovepress.com)
  • Ceftriaxone is recommended as the primary drug for treatment of meningitis and is available in the public health system in Uganda ( 2 ). (cdc.gov)
  • Antibiotic treatment was considered inappropriate on the basis of a wrong dosage regimen, wrong indication, or both based on the British National Formulary. (springer.com)