Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
A PEPTIC ULCER located in the DUODENUM.
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.
Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.
Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.
A lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa.
Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
A slow-growing mycobacterium that infects the skin and subcutaneous tissues, giving rise to indolent BURULI ULCER.
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
Material used for wrapping or binding any part of the body.
A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.
Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. Since the procedure leaves the vagal branches to the antrum and PYLORUS intact, it circumvents gastric drainage required with truncal vagotomy techniques.
Hydrochloric acid present in GASTRIC JUICE.
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.
Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)
Endoscopic examination, therapy or surgery of the interior of the stomach.
Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
The return of a sign, symptom, or disease after a remission.
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Impaired digestion, especially after eating.
The characteristic three-dimensional shape of a molecule.
Control of bleeding performed through the channel of the endoscope. Techniques include use of lasers, heater probes, bipolar electrocoagulation, and local injection. Endoscopic hemostasis is commonly used to treat bleeding esophageal and gastrointestinal varices and ulcers.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.
Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
Gastrointestinal symptoms resulting from an absent or nonfunctioning pylorus.
Antibodies produced by a single clone of cells.
A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.
Pathological processes in the ESOPHAGUS.
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
Elements of limited time intervals, contributing to particular results or situations.
Evaluation of the nature and extent of nursing problems presented by a patient for the purpose of patient care planning.
Equipment on which one may lie and sleep, especially as used to care for the hospital patient.
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
A variety of surgical reconstructive procedures devised to restore gastrointestinal continuity, The two major classes of reconstruction are the Billroth I (gastroduodenostomy) and Billroth II (gastrojejunostomy) procedures.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.
Use of plants or herbs to treat diseases or to alleviate pain.
A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)
A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).
The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)
A nucleoside consisting of the base guanine and the sugar deoxyribose.
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Material, usually gauze or absorbent cotton, used to cover and protect wounds, to seal them from contact with air or bacteria. (From Dorland, 27th ed)
Gastric analysis for determination of free acid or total acid.
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Cytosine nucleotides which contain deoxyribose as the sugar moiety.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.
A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)
Vomiting of blood that is either fresh bright red, or older "coffee-ground" in character. It generally indicates bleeding of the UPPER GASTROINTESTINAL TRACT.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Therapy with two or more separate preparations given for a combined effect.
Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.
The black, tarry, foul-smelling FECES that contain degraded blood.
Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.
Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Adenine nucleotides which contain deoxyribose as the sugar moiety.
Strips of elastic material used to apply pressure to body parts to control EDEMA and aid circulation.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
Substances that reduce the growth or reproduction of BACTERIA.
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
Research carried out by nurses that uses interviews, data collection, observation, surveys, etc., to evaluate nursing, health, clinical, and nursing education programs and curricula, and which also demonstrates the value of such evaluation.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Tumors or cancer of the STOMACH.
A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Death and putrefaction of tissue usually due to a loss of blood supply.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Anatomical and functional disorders affecting the foot.
A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Skin diseases caused by bacteria.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
A republic in western Africa, south of NIGER and between TOGO and NIGERIA. Its capital is Porto-Novo. It was formerly called Dahomey. In the 17th century it was a kingdom in the southern area of Africa. Coastal footholds were established by the French who deposed the ruler by 1892. It was made a French colony in 1894 and gained independence in 1960. Benin comes from the name of the indigenous inhabitants, the Bini, now more closely linked with southern Nigeria (Benin City, a town there). Bini may be related to the Arabic bani, sons. (From Webster's New Geographical Dictionary, 1988, p136, 310 & Room, Brewer's Dictionary of Names, 1992, p60)
An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3d ed)
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Substances that reduce or suppress INFLAMMATION.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.
Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.
The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.
Pathological development in the ILEUM including the ILEOCECAL VALVE.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.
Research carried out by nurses in the clinical setting and designed to provide information that will help improve patient care. Other professional staff may also participate in the research.
Invasion of the site of trauma by pathogenic microorganisms.
A genus of bacteria causing GRANULOMA INGUINALE and other granulomatous lesions.
Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.
Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
The structure of one molecule that imitates or simulates the structure of a different molecule.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
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Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (1/1640)

OBJECTIVE: To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease. DESIGN: Randomised, multicentre, double blind, controlled study. Patients with heartburn and normal endoscopy results or mild erosive changes received omeprazole 10 mg or 20 mg daily or ranitidine 150 mg twice daily for 2 weeks. Patients remaining symptomatic had omeprazole 10 mg or ranitidine dose doubled for another 2 weeks while omeprazole 20 mg was continued for 2 weeks. Patients who were symptomatic or mildly symptomatic were followed up for 12 months. Recurrences of moderate or severe heartburn during follow up were treated with the dose which was successful for initial symptom control. SETTING: Hospitals and primary care practices between 1994 and 1996. SUBJECTS: 677 patients with gastro-oesophageal reflux disease. MAIN OUTCOME MEASURES: Total time off active treatment, time to failure of intermittent treatment, and outcomes ranked from best to worst. RESULTS: 704 patients were randomised, 677 were eligible for analyses; 318 reached the end of the study with intermittent treatment without recourse to maintenance antisecretory drugs. The median number of days off active treatment during follow up was 142 for the entire study (281 for the 526 patients who reached a treatment related end point). Thus, about half the patients did not require treatment for at least 6 months, and this was similar in all three treatment groups. According to outcome, 378 (72%) patients were in the best outcome ranks (no relapse or one (or more) relapse but in remission until 12 months); 630 (93%) had three or fewer relapses in the intermittent treatment phase. Omeprazole 20 mg provided faster relief of heartburn. The results were similar in patients with erosive and non-erosive disease. CONCLUSIONS: Intermittent treatment is effective in managing symptoms of heartburn in half of patients with uncomplicated gastro-oesophageal reflux disease. It is simple and applicable in general practice, where most patients are seen.  (+info)

Can restrictions on reimbursement for anti-ulcer drugs decrease Medicaid pharmacy costs without increasing hospitalizations? (2/1640)

OBJECTIVE: To examine the impact of a policy restricting reimbursement for Medicaid anti-ulcer drugs on anti-ulcer drug use and peptic-related hospitalizations. DATA SOURCES/STUDY SETTING: In addition to U.S. Census Bureau data, all of the following from Florida: Medicaid anti-ulcer drug claims data, 1989-1993; Medicaid eligibility data, 1989-1993; and acute care nonfederal hospital discharge abstract data (Medicaid and non-Medicaid), 1989-1993. STUDY DESIGN: In this observational study, a Poisson multiple regression model was used to compare changes, after policy implementation, in Medicaid reimbursement for prescription anti-ulcer drugs as well as hospitalization rates between pre- and post-implementation periods in Medicaid versus non-Medicaid patients hospitalized with peptic ulcer disease. PRINCIPAL FINDINGS: Following policy implementation, the rate of Medicaid reimbursement for anti-ulcer drugs decreased 33 percent (p < .001). No associated increase occurred in the rate of Medicaid peptic-related hospitalizations. CONCLUSIONS: Florida's policy restricting Medicaid reimbursement for anti-ulcer drugs was associated with a substantial reduction in outpatient anti-ulcer drug utilization without any significant increase in the rate of hospitalization for peptic-related conditions.  (+info)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (3/1640)

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.  (+info)

Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. (4/1640)

Anti-ulcer effects of cetraxate, a new compound possessing anti-plasmin, anti-casein and anti-trypsin actions were investigated by using experimental gastric ulcer models in rats. Cetraxate, 300 mg/kg p.o. showed significant inhibitory effects of 65.3%, 70.0%, 30.2%, and 67.1% against aucte types of ulcers producing by aspirin, phenylbutazone, indomethacin, and pyloric ligature (Shay's ulcer), respectively. These effects were greater than those obtained by gefarnate and aluminum sucrose sulfate may be mainly attributed to the protecting action of this drug on gastric mucosa. Ctraxate further revealed remarkable inhibitory effects on chronic types of ulcers produced by acetic acid, clamping, and clamping-cortisone. In acetic acid ulcer in particular, cetraxate was found to have a dose-dependent inhibitory effect at doses over 50 mg/kg. Of test drugs including L-glutamine and methylmethionine sulfonium chloride, cetraxate showed the most remarkable inhibitory effect on beta-glucuronidase activity in ulcer tissue of these three types of ulcers. These findings suggest that cetraxate may prevent the connective tissue in the ulcer location from decomposition due to lysosomal enzymes such as beta-glucuronidase, thereby accelerating the recovery from ulcer.  (+info)

Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. (5/1640)

1. This study used intravital microscopy to investigate the receptors stimulated by amylin which shares around 50% sequence homology with the vasodilator calcitonin gene-related peptide (CGRP) in the hamster cheek pouch microvasculature in vivo. 2. Receptor agonists dilated arterioles (diameters 20-40 microm). The -log of the concentrations (+/- s.e.mean; n = 8) causing 50% increase in arteriole diameter were: human betaCGRP (10.8 +/- 0.3), human alphaCGRP (10.8 +/- 0.4), rat alphaCGRP (10.4 +/- 0.3). Rat amylin and the CGRP2 receptor selective agonist [Cys(ACM2,7]-human alphaCGRP were 100 fold less potent (estimates were 8.5 +/- 0.4 and 8.2 +/- 0.3 respectively). 3. The GCRP1 receptor antagonist, CGRP8-37 (300 nmol kg(-1); i.v.) reversibly inhibited the increase in diameter evoked by human alphaCGRP (0.3 nM) from 178 +/- 22% to 59 +/- 12% (n = 8; P < 0.05) and by rat amylin (100 nM) from 138 +/- 23% to 68 +/- 24% (n = 6; P < 0.05). CGRP8-37 did not inhibit vasodilation evoked by substance P (10 nM; n = 4: P > 0.05). 4. The amylin receptor antagonist, amylin8-37 (300 nmol kg(-1); i.v.) did not significantly inhibit the increase in diameter evoked by human alphaCGRP (0.3 nM) which was 112 +/- 26% in the absence, and 90 +/- 29% in the presence of antagonist (n = 4; P < 0.05); nor that evoked by rat amylin (100 nM) which was 146 +/- 23% in the absence and 144 +/- 32% in the presence of antagonist (n = 4; P > 0.05). 5. The agonist profile for vasodilatation and the inhibition of this dilatation by CGRP8-37, although not the amylin8-37 indicates that amylin causes vasodilatation through interaction with CGRP1 receptors in the hamster cheek pouch.  (+info)

Maleic acid and succinic acid in fermented alcoholic beverages are the stimulants of gastric acid secretion. (6/1640)

Alcoholic beverages produced by fermentation (e.g., beer and wine) are powerful stimulants of gastric acid output and gastrin release in humans. The aim of this study was to separate and specify the gastric acid stimulatory ingredients in alcoholic beverages produced by fermentation. Yeast-fermented glucose was used as a simple model of fermented alcoholic beverages; it was stepwise separated by different methods of liquid chromatography, and each separated solution was tested in human volunteers for its stimulatory action on gastric acid output and gastrin release. Five substances were detected by high-performance liquid chromatography and were analyzed by mass spectrometry and 1H-13C nuclear magnetic resonance spectroscopy. At the end of the separation process of the five identified substances, only the two dicarboxylic acids, maleic acid and succinic acid, had a significant (P < 0.05) stimulatory action on gastric acid output (76% and 70% of fermented glucose, respectively), but not on gastrin release. When given together, they increased gastric acid output by 100% of fermented glucose and by 95% of maximal acid output. We therefore conclude that maleic acid and succinic acid are the powerful stimulants of gastric acid output in fermented glucose and alcoholic beverages produced by fermentation, and that gastrin is not their mediator of action.  (+info)

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole. (7/1640)

BACKGROUND: Omeprazole has a greater intragastric pH elevating effect in Helicobacter pylori positive than negative subjects. Ammonia production by H pylori has been suggested as a probable mechanism. AIMS: To assess the effect of H pylori status on gastric acid secretion during omeprazole treatment, and to examine the possible role of ammonia neutralisation of intragastric acid in increased omeprazole efficacy in infected subjects. METHODS: Twenty H pylori positive and 12 H pylori negative healthy volunteers were examined before and six to eight weeks after commencing omeprazole 40 mg/day. On both occasions plasma gastrin and acid output were measured basally and in response to increasing doses of gastrin 17 (G-17). Gastric juice ammonium concentrations were also measured. RESULTS: Prior to omeprazole, measurements were similar in the H pylori positive and negative subjects. During omeprazole, median basal intragastric pH was higher in the H pylori positive (7.95) versus negative (3.75) subjects (p<0.002). During omeprazole basal, submaximal (180 pmol/kg/h G-17), and maximal acid outputs (800 pmol/kg/h G-17) were lower in H pylori positive subjects (0.0, 3.6, 6.0 mmol/h respectively) versus negative subjects (0.3, 14.2, 18.6 mmol/h) (p<0.03 for each). This effect was not explained by neutralisation by ammonia. CONCLUSION: The presence of H pylori infection leads to a more profound suppression of acid secretion during omeprazole treatment. The effect cannot be explained by neutralisation of intragastric acid by bacterial ammonia production and its precise mechanism has to be explained.  (+info)

Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels. (8/1640)

The anti-ulcer effects of nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester] were examined on water-immersion plus restraint stress-induced and aspirin-induced gastric ulcers in rats, compared with those of cimetidine. Nicorandil (3 and 10 mg/kg) given orally to rats dose-dependently inhibited the development of acid-related damage (water-immersion- and aspirin-induced gastric lesions) in the models. Cimetidine (50 mg/kg, p.o.) also had anti-ulcer effects in the same models. However, in the presence of glibenclamide (20 mg/kg, i.v.), an antagonist of K(ATP) channels, nicorandil did not inhibit the formation of gastric lesions. Nicorandil (10 mg/kg) given intraduodenally (i.d.), like cimetidine (50 mg/kg), significantly reduced the volume of the gastric content, total acidity and total acid output in the pylorus ligation model. Glibenclamide reversed the changes caused by i.d. nicorandil. I.v. infusion of nicorandil (20 microg/kg per min) significantly increased gastric mucosal blood flow, without affecting blood pressure and heart rate, but the increase in the blood flow was not observed after i.v. treatment with glibenclamide (20 mg/kg). These results indicate that nicorandil administered orally to rats produces the anti-ulcer effect by reducing the aggressive factors and by enhancing the defensive process in the mucosa through its K(ATP)-channel-opening property.  (+info)

1. Recently, some cases have been reported where intravenous use of omeprazole was followed by loss of vision. We followed up a cohort of close to 140,000 persons during periods of treatment and non-treatment with five anti-ulcer drugs.. 2. The relative risk of vascular disorders of the eye during use of omeprazole compared with non-use was 1.8 (95% CI 0.5-6.0). Use of other anti-ulcer drugs was associated with a similar risk of vascular disorders. The relative risk associated with current use of any anti-ulcer drug was 1.9 (95% CI 1.1-3.4). We did not find a single case of optic inflammatory disorder during treatment with any of the five anti-ulcer drugs.. 3. These results do not suggest a major increased risk for vascular or inflammatory disorders of the eye associated with use of omeprazole or other anti-ulcer drugs.. ...
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Chak, M. C. [翟敏莉]. (2004). A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-induced gastrointestinal effects. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_ ...
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Initially 500 microgramskg once daily (max. Per dose 20 mg), increased if necessary to 2 mgkg once daily (max. Per dose 40 mg), injection to be given over 5.
... a novel anti-gastric ulcer agent: tautomeric change of imidazole moiety upon complexation". Chem Pharm Bull. 38 (11): 3140-6. ... which has been clinically used to treat gastric ulcers. Its mechanism of action is believed to oxygen radical scavenging, anti- ... Forty-two patients with stage II-IV pressure ulcers for 4 or more weeks were allocated to 1 of 3 groups in order of recruitment ... Zinc L-carnosine (ZnC), which is clinically used as gastric ulcer treatment in Japan, has been suggested to have the potential ...
... is a systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting ... was achieved in patients with gastric ulcer and duodenal ulcer respectively. In patients with acute gastritis and acute gastric ... Hyeoyun (1989). "Peptic ulcers for the clinical effectiveness of Troxipide". Latest Med. 32 (2): 125-31. Dewan B, ... In patients with APDs like dyspepsia, gastritis, GERD and/or gastric ulcer, uncontrolled with acid inhibitors viz. proton pump ...
... an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese ... and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor ... Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. ... Ito, M; Yokochi, E; Kobayashi, C; Suzuki, Y (1982). "Studies on defensive factors of experimental ulcers (2). Increasing action ...
... antifungal agent), meloxicam and fentiazac (anti-inflammatory agents) and nizatidine (anti-ulcer agent). Consequently, ... A couple of the compounds that were analysed for in vivo anti-cancer activity contained thiazole derivatives that had been ... Thiazoles are found in a number of pharmacological compounds such as tiazofurin and dasatinib (antineoplastic agents), ...
Anti-Infective Effects of Sugar-Vaseline Mixture on Leg Ulcers O'Meara S, Martyn-St James M (May 2013). "Foam dressings for ... It is not certain which dressings and topical agents are most effective for healing venous leg ulcers. Silver-containing ... hence leg ulcers). They are the major occurrence of chronic wounds, occurring in 70% to 90% of leg ulcer cases. Venous ulcers ... A venous ulcer is typically shallow with irregular sloping edges whereas an arterial ulcer can be deep and has a 'punched out' ...
Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ... Refractory corneal ulcers are superficial ulcers that heal poorly and tend to recur. They are also known as indolent ulcers or ... Superficial ulcers involve a loss of part of the epithelium. Deep ulcers extend into or through the stroma and can result in ... Melting ulcers are a type of corneal ulcer involving progressive loss of stroma in a dissolving fashion. This is most commonly ...
... the use of anti-diabetic agents, the treatment of gout, the treatment of peptic ulcers, anxiolytic drugs, and the therapy of ...
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more ... A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal ... Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing ... Cytoprotection is a process by which chemical compounds provide protection to cells against harmful agents. ...
Examples of metallopharmaceuticals include: bismuth subsalicylate - a mild anti-diarrheal also used in treating peptic ulcers ... 2005). Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley and Sons. ISBN 978 ... Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents. The efficiency of metallopharmaceuticals ... "Silver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta- ...
Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis. „ ... Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents ... Helicobacter pylori and bleeding duodenal ulcer: prevalence of the infection and role of non-steroidal anti-inflammatory drugs ... Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, ...
Some anti-acne creams contain drying agents such as benzoyl peroxide (in concentrations of 2.5 - 10% ). Pressure sores are ... A known example of pressure sore is a bedsore called pressure ulcer. Add from When cleaning the stoma area, plain warm water ... Formulations with moisturising, anti-inflammatory, anti-microbial and wound healing properties are often used, but no preferred ... 2010 Draelos ZD Active agents in common skin care products - Plastic and Reconstructive Surgery, 2010 Blume-Peytavi U, Hauser M ...
Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ... Melting ulcersEdit. Melting ulcers are a type of corneal ulcer involving progressive loss of stroma in a dissolving fashion. ... Refractory corneal ulcersEdit. Main article: Recurrent corneal erosion. Refractory corneal ulcers are superficial ulcers that ... Superficial ulcers involve a loss of part of the epithelium. Deep ulcers extend into or through the stroma and can result in ...
A root extract is taken thrice daily for the treatment of gastric ulcers, and taken twice daily for the treatment of jaundice ... Its use as an antiinflammatory and analgesic agent has been supported by experiments in mice. The rhizome, cooked or raw, has ... Das BN, Biswas BK (2012). "Anti-inflammatory activity of the rhizome extract of Alpinia nigra". International Research Journal ...
These infectious agents produce proteases and collagenases which break down the corneal stroma. Complete loss of the stroma can ... Contains macroglobulins with anti-collagenase effects.. A combination of the above may be necessary early in the disease course ... Melting ulcers[edit]. Melting ulcers are a type of corneal ulcer involving progressive loss of stroma in a dissolving fashion. ... Refractory corneal ulcers are superficial ulcers that heal poorly and tend to recur. They are also known as indolent ulcers or ...
... is used as a mordant agent with dyes like alizarin, both alone and in combination. Together with aluminium ... It has therapeutic applications for its anti-itching, astringent, and antiseptic properties, and, as an over-the-counter ... while diluted forms are used as gargles for conditions like aphthous ulcers of the mouth, including with amino acid additives ... the aluminium acetates are used topically in humans as antiseptic agents, which also cause body tissues to shrink. Its ...
Further, like all medications, the agents have other associated toxicities, with side effects such as oral ulcers, peripheral ... Bellin is currently testing two anti-inflammatory drugs that are already on the market to see if they may be useful in ... Current immunosuppressive regimens are capable of preventing islet failure for months to years, but the agents used in these ... In addition, and somewhat ironically, the most commonly used agents (like calcineurin inhibitors and rapamycin) are also known ...
They are the most common prescribed class of topical anti allergy agent. Olopatadine (Patanol, Pazeo) and ketotifen fumarate ( ... Maxwell-Lyons sign, shield ulcer, cobblestones papillae, gelatinous thickening at the limbus, and Horner-Trantas dots are ... Treatment consists of antihistamine, mast cell stabilizers, dual mechanism anti-allergen agents, or topical antihistamines. ... Common agents include Staph. aureus, Mycobacterium tuberculosis, Chlamydia and Candida. A detailed history allows doctors to ...
... anti-inflammatory agents such as corticosteroids have not been shown to be beneficial in healing, but do have significant anti- ... It aids in healing and giving relief from pain of ischemic ulcers. Bypass can sometimes be helpful in treating limbs with poor ... There may be a benefit of using bone marrow-derived stem cells in healing ulcers and improving pain-free walking distance, but ... Debridement is done in necrotic ulcers. In gangrenous digits, amputation is frequently required. Above-knee and below-knee ...
Topical analgesics / anesthetics / anti-inflammatory agents. Reduce pain. Benzydamine hydrochloride mouthwash or spray,[13] ... Aphthous ulcers typically begin as erythematous macules (reddened, flat area of mucosa) which develop into ulcers that are ... Unlike true herpetic ulcers, herpetiforme ulcers are not preceded by vesicles (small, fluid filled blisters).[8] Herpetiforme ... Behçet's disease is a triad of mouth ulcers, genital ulcers and anterior uveitis.[7] The main feature of Behçet's disease is ...
Symptoms of oral cancer can include velvety red patches and white patches, loose teeth and non-healing mouth ulcers. The risk ... It mainly presents following radiotherapy to the jaw or as a complication in patients taking specific anti-angiogenic drugs. As ... Habits such as tobacco chewing/smoking and alcohol are the major causative agents, although human papillomavirus has also ... Oral cancers have a range of symptoms including red and white patches, ulcer and non-healing sockets. Another symptom that ...
... turning it up when the body comes under attack from pathogens or other disease agents, and damping it when the danger is ... through its immunoglobulin and other anti-microbial factors) and growth/healing factor constituents.[55] As pointed out by ... mechanisms have relevance for multiple conditions affecting all areas of the world and socioeconomic groups such as ulcers, ... drugs and infectious microbes not only damages the gut but can lead to influx of damaging agents into the bloodstream. These ...
... decubitus ulcers, infected pilonidal cyst or sinus, Meleney's ulcer infected diabetic (vascular or trophic) ulcers, bite wound ... Empiric use of agents effective against enterococci is recommended and agents effective against methicillin-resistant S. aureus ... Expert Rev Anti Infect Ther. 2007; 5:991-1006 "Solomkin JS, Mazuski JE, Bradley JS, Rodvold KA, Goldstein EJ, Baron EJ, O'Neill ... Because of the poor penetration of many antimicrobial agents through the blood-brain barrier, there are few agents available ...
... have anti-dyspeptic effects for non-ulcer dyspepsia with "encouraging safety profiles". A 2004 meta-analysis of the multiple ... Prokinetic agents would empirically seem to work well since delayed gastric emptying is considered a major pathophysiological ... In a small minority of cases it may be the first symptom of peptic ulcer disease (an ulcer of the stomach or duodenum) and, ... duodenal and gastric ulcers, and NSAID-induced ulcer healing and prevention, but not functional dyspepsia. However, evidence- ...
Agent. Example(s) Viral. chickenpox, hand, foot and mouth disease, herpangina, herpetic stomatitis, human immunodeficiency ... non-steroidal anti-inflammatory drugs, nicorandil[11] (may be prescribed for angina) and propylthiouracil (e.g. used for ... A mouth ulcer is an ulcer that occurs on the mucous membrane of the oral cavity.[1] Mouth ulcers are very common, occurring in ... Herpetiform ulcers begin as small blisters (vesicles) which break down into 2-3mm sized ulcers. Herpetiform ulcers appear in " ...
Water as a cleansing agent, especially in chronic wounds has been proposed and is widely used especially in the management of ... In vitro studies on clinical isolates of E. coli and S. epidermidis have demonstrated the anti-biofilm efficacy of PHMB. The ... ulcer healing patterns were evaluated. Within the first 3 months of treatment, a shorter time to healing was recorded in the ... Criteria by which a wound cleansing agent could be deemed suitable for use on wounds include: non-toxic to mammalian cells ...
Chemical warfare agents. Environ. Toxicol. Pharmacol. 2008, 26, 113-122 Vilensky, Joel A., and Kent Redman. "British anti- ... skin ulcers, basal cell carcinoma, and squamous cell carcinoma. Basic first aid for lewisite exposure is decontamination and ... "Ocular toxicity of chemical warfare agents." Handbook of Toxicology of Chemical Warfare Agents. Academic Press, 2015. 535-555 ... Lewisite immediately damages the skin, eyes, and respiratory tract and is a strong irritant and blistering agent. Due to its ...
Novichok agents are neurotoxic organophosphorus compounds and are considered more potent than VX gas, also a neurotoxic ... Cholinesterase inhibitors (ChEIs), also known as anti-cholinesterase, are chemicals that prevent the breakdown of the ... peptic ulcer disease, seizures, weight loss, rhinorrhea, salivation, muscle cramps, and fasciculations. ChEIs are indirect- ... Since November 2019 the group of ACheIs known as Novichoks have been banned as agents of warfare under the Chemical Weapons ...
Spagnolo P, Del Giovane C, Luppi F, Cerri S, Balduzzi S, Walters EH, D'Amico R, Richeldi L (2010). "Non-steroid agents for ... Zhou C, Liu F, Gallo PH, Baratz ME, Kathju S, Satish L (November 2016). "Anti-fibrotic action of pirfenidone in Dupuytren's ... on a gel form for the treatment of scars and fibrotic tissue and has proven to be effective in the treatment of skin ulcers ... Other research shows that pirfenidone may be an effective anti-fibrotic treatment for chronic liver fibrosis. "Esbriet 267 mg ...
Another Anti-TNF agent, etanercept, may be useful in people with mainly skin and mucosal symptoms.[26] ... genital ulcers (including anal ulcers and spots in the genital region and swollen testicles or epididymitis in men) ... However, some HSPs share a similarity in bacteria and humans.[13] The anti-HSP60 and anti-HSP65 antibodies that target HSPs ... High-dose corticosteroid therapy is often used for severe disease manifestations.[23] Anti-TNF therapy such as infliximab has ...
She is accused of being a spy for the Comintern, and working with such agents as Richard Sorge, who was among her lovers. Agnes ... She covered many topics, including the Anti-Japanese War as a major war correspondent. She was also in Xi'an during the Xi'an ... She died in the UK in 1950 after surgery for an ulcer. Her ashes were buried at the Babaoshan Revolutionary Cemetery in Beijing ... According to PBS, in her work as triple agent for Communists in China, India, and the Soviet Union, Smedley "was one of the ...
See also: Anti-diabetic medication. There are several classes of anti-diabetic medications available. Metformin is generally ... A second oral agent of another class or insulin may be added if metformin is not sufficient after three months.[87] Other ... Krentz AJ, Bailey CJ (February 2005). "Oral antidiabetic agents: current role in type 2 diabetes mellitus". Drugs. 65 (3): 385- ... As of 2015 there was no significant difference between these agents.[87] A 2018 review found that SGLT2 inhibitors may be ...
Hormonal agents[edit]. In women, the use of combined birth control pills can improve acne.[100] These medications contain an ... Proposed mechanisms for tea tree oil's anti-acne effects include antibacterial action against C. acnes and anti-inflammatory ... "Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. PMC 6325184. PMID 30397052.. ... Hassoun LA, Chahal DS, Sivamani RK, Larsen LN (June 2016). "The use of hormonal agents in the treatment of acne". Seminars in ...
Other agents causing ophthalmia neonatorum include Herpes simplex virus (HSV 2), Staphylococcus aureus, Streptococcus ...
ofatumumab (HuMax-CD20) a fully human B cell-depleting agent.[53]. *Third-generation anti-CD20s such as obinutuzumab have a ... myasthenia gravis and Epstein-Barr virus-positive mucocutaneous ulcers.[2][3][4][5] It is given by slow injection into a vein.[ ... Other anti-CD20 monoclonals[edit]. The efficacy and success of Rituximab has led to some other anti-CD20 monoclonal antibodies ... T Shaw, J Quan, and M Totoritis, "B cell therapy for rheumatoid arthritis: the rituximab (anti-CD20) experience", Ann Rheum Dis ...
ofatumumab (HuMax-CD20) a fully human B cell-depleting agent.[55]. *Third-generation anti-CD20s such as obinutuzumab have a ... myasthenia gravis and Epstein-Barr virus-positive mucocutaneous ulcers.[2][3][4][5] It is given by slow injection into a vein.[ ... Other anti-CD20 monoclonalsEdit. The efficacy and success of Rituximab has led to some other anti-CD20 monoclonal antibodies ... The use of rituximab has not been proven to be efficacious in this setting and like all depleting agents, carries with it the ...
Commonly used agents are prednisone, mycophenolate, cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and ... nephrotoxins like radiologic contrast and non-steroidal anti-inflammatory drugs), antihypertensives, diet and weight ... An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D ...
It is the causative agent of Johne's disease, which affects ruminants such as cattle, and suspected causative agent in human ... Professor John Hermon-Taylor of Kings College London is developing a new vector type anti MAP vaccine which he claims is both ... It has long been suspected as a causative agent in Crohn's disease in humans,[4][5] but studies have been unable to show ... One study concluded that MAP "may act as a causative agent, have a role in the context of secondary infection, which may ...
... anthelmintic agent, for the treatment of cough, respiratory diseases, skin diseases, wounds, ulcer, gout, and rheumatism.[8] ... "India-Tanzania-Thailand Scientists to Study 'Bitter Gourd' for anti-diabetes". zmescience.com. Retrieved 30 May 2017 ...
Calmette's and Guerin's anti-tuberculosis vaccineEdit. By the beginning of the 20th century, the improvement of the general ... Alphonse Laveran got the 1907 Nobel Prize for his research on the role of protozoans as disease agents (notably, his discovery ... diagnostic test for the detection of the Helicobacter pylori bacterium which is implicated in the formation of stomach ulcers. ... The anti-diphtheria serum which was able to agglutinate the bacteria and neutralize the toxin was supplied by a horse ...
These three anti-leprosy drugs are still used in the standard MDT regimens. None of them is used alone because of the risk of ... In 1873 G. H. Armauer Hansen in Norway discovered the causative agent of leprosy, Mycobacterium leprae. This was the first ... Given by enema may cause peri-anal ulcers and fissures. Given by injection the drug caused fever and other local reactions. ... The search for more effective anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s.[4] Later ...
Aronson, edited by Jeffrey K. (2008). Meyler's side effects of analgesics and anti-inflammatory drugs. Amsterdam: Elsevier ... "Antimicrobial agents for treating uncomplicated urinary tract infection in women". Cochrane Database of Systematic Reviews. 10 ... Methenamine is another agent used for this purpose as in the bladder where the acidity is low it produces formaldehyde to which ... Medications that commonly cause this problem include the chemotherapeutic agent cyclophosphamide with rates of 2 to 40%.[47] ...
In 2002, the United States Food and Drug Administration (FDA) approved ibritumomab tiuxetan (Zevalin), which is an anti-CD20 ... stomach or duodenal ulcers[13][14] This collateral radiation is commonly caused by non-targeted delivery (reflux) of the ... These medications were the first agents of what is known as radioimmunotherapy, and they were approved for the treatment of ... which is a combination of an iodine-131 labelled and an unlabelled anti-CD20 monoclonal antibody.[76] ...
... should be given to possibility of strep species as cause that are still sensitive to traditional anti-staphylococcus agents ... In those cases of abscess which do require antibiotic treatment, Staphylococcus aureus bacteria is a common cause and an anti- ... Chronic undermining burrowing ulcers. *Fournier gangrene. *Elephantiasis nostras. *Blistering distal dactylitis. *Botryomycosis ...
... single-arm pilot study in patients with severe plaque-type psoriasis treated with an oral anti-inflammatory agent, apremilast ... Orphan indications by the FDA include graft-versus-host disease, mycobacterial infection, recurrent aphthous ulcers, severe ... The discovery of the anti-inflammatory, anti-angiogenic and anti-tumor activities of thalidomide increased the interest of ... In vivo anti-tumor activity of thalidomide is believed to be due to the potent anti-angiogenic effect and also through changes ...
Ocular vascular disorder agents}}. *{{Ophthalmological anti-infectives}}. Project notice[edit]. The template for marking an ... Copyedit : Fungal keratitis, Blepharochalasis, Phthiriasis, Eye trauma, Optic neuropathy, Keratoglobus, Corneal ulcer, Cone ... Corneal ulcer, Corneal abrasion, Ocular tilt reaction ...
The choice of the antihypertensive agent is open as long as the blood pressure is controlled to desired level. However, ... Cyclophosphamide ( traded as endoxan & cytoxan )and Isotretinoin have commonly been used, often with anti-platelet/ ... This, too, suggests an immune pathology rather than direct interference by outside agents. ... Other agents such as mycophenolate mofetil, ciclosporin and mizoribine have also been tried with varying results. ...
The most common cause in patients with diagnosed, chronic hypertension who have discontinued anti hypertensive medications.[6] ... Several classes of antihypertensive agents are recommended, with the choice depending on the cause of the hypertensive crisis, ... With the usage of anti hypertensives, the rates of hypertensive emergencies has declined from 7% to 1% of patients with ... Risk factors for hypertensive emergency include age, obesity, noncompliance to anti hypertensive medications, female sex, ...
Nonsteroidal anti-inflammatory drugs Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically ... GI bleeds; ulcers; Reye syndrome; nephrotoxicity; blood dyscrasias (rarely); Stevens-Johnson syndrome (uncommon/rare) ... Psychotropic agents[edit]. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Main article: Nonsteroidal anti-inflammatory drug. Nonsteroidal anti-inflammatory drugs (usually abbreviated to NSAIDs), are a ...
These agents alter gut perception of fullness and can help relieve anxiety and apprehension. ... severe peptic ulcer disease, bowel obstruction or after certain types of abdominal surgery. ... such as antidepressants and anti-spasmodics, can contribute to reduced gut motility. Studies have shown that swallowing air ...
敗血症常規治療包括靜脈輸液及抗生素治療,通常需要在加護病房內進行生命徵象監測。升壓劑藥物(英语:Antihypotensive_agent)使用於輸液無法有效維持血壓時,而呼吸器(英语:Mechanical_ventilation)及透析治療能夠減輕肺臟 ... ulcers)及褥瘡的發生。使用胰島素嚴格
From the training course titled "Smallpox: Disease, Prevention, and Intervention" (www.bt.cdc.gov/agent/smallpox/training/ ... Durbach, Nadja (2005). Bodily Matters: The Anti-Vaccination Movement in England, 1853-1907. ISBN 978-0-8223-3423-1. .. ... Blindness results in approximately 35 percent to 40 percent of eyes affected with keratitis and corneal ulcer. Hemorrhagic ... The British used smallpox as a biological warfare agent at the Siege of Fort Pitt during the French and Indian Wars (1754-1763 ...
... stress ulcers, and pressure ulcers unless other conditions prevent such interventions.[10] Some people might benefit from tight ... "Expert Review of Anti-infective Therapy. 10 (6): 701-6. doi:10.1586/eri.12.50. PMC 3488423. PMID 22734959.. ... Paralytic agents are not suggested for use in sepsis cases in the absence of ARDS, as a growing body of evidence points to ... However, these agents may precipitate prolongation of the QT interval and consequently provoke a ventricular arrhythmia such as ...
Keratosis, ulcer, atrophy, and necrobiosis. *Vasculitis. *Fat. *Neutrophilic and eosinophilic *Congenital. *Neoplasms and ...
... treatment of duodenal ulcers caused by Helicobacter pylori, prevention of gastric ulcers in those on chronic NSAID therapy, and ... The second of two-deals is an agreement to study a combination treatment of MEDI4736 and Innate Pharma's Phase II anti-NKG2A ... AstraZeneca and Astex ally for anticancer agents Business Intelligence, 1 July 2005 ... In 2005, the company acquired KuDOS Pharmaceuticals, a UK biotech company, for £120m[14] and entered into an anti-cancer ...
A contrast medium, usually a radiocontrast agent such as barium sulfate mixed with water, is ingested or instilled into the ... Leakage of barium sulfate into the abdominal cavity may occur in people with duodenal ulcers or other perforations and may lead ... swallow studies are better than endoscopy at demonstrating the anatomic findings in gastroesophageal reflux disease after anti- ... ulcers, tumors, and gastrointestinal dysmotility, as well as to detect foreign bodies.[3][6] Although barium X-ray examinations ...
2005). "Anti-ulcer drugs promote IgE formation toward dietary antigens in adult patients". FASEB J. 19 (6): 656-658. doi: ... Patients who take these agents develop higher levels of immunoglobulin E against food, whether they had prior antibodies or not ... For ulcer treatment, a night-time dose is especially important - as the increase in gastric/duodenal pH promotes healing ... Short-term and maintenance therapy of gastric and duodenal ulcers. *Ranitidine can also be given with NSAIDs to reduce the risk ...
Recent reports on recombinant PYY 3-36 suggest that this agent may contribute to weight loss by suppressing appetite. ... stomachs had been removed because of cancer or large ulcers, and their esophagi had been attached directly to their small ... "Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans". Nature ...
... is used as an anti-inflammatory agent for both acute and long-term inflammation,[37] as well as for treatment of ... One common adverse effect is an upset stomach.[4] More significant side effects include stomach ulcers, stomach bleeding, and ... 1982). "Aspirin and similar analgesic and anti-inflammatory agents". Martindale: the extra pharmacopoeia (28th ed.). ... "Expert Review of Anti-Infective Therapy. 8 (2): 197-203. doi:10.1586/eri.09.109. PMC 2845298. PMID 20109049.. ...
... metal compounds are used as anti-microbial agents, but their antiviral activities have rarely been explored, the researchers ... Anti-ulcer drug shows promise in suppressing coronavirus. Generally, metal compounds are used as anti-microbial agents, but ... They identified RBC as a potent anti SARS-CoV-2 agent. RBC targets a protein called Nsp13, which is essential for SARS-CoV-2 to ... Generally, metal compounds are used as anti-microbial agents, but their antiviral activities have rarely been explored, the ...
Trading Company of Antiulcer & Antisecretory based in Gurgaon, India ... Our range of these products is considered as one of the efficient anti-ulcer agents. Generic Name. Combination. Strength / ...
Home / Treatment and Drugs / Stomach Care / Anti-Ulcer. Anti-Ulcer. *View. * List ... Immunity Agents. *Multivitamins. *Stress Management. *Daily Living *. Skin Care. *Acne/Pimples. *Anti-Aging ...
Chapter 14 Antihistamines and Anti-Ulcer Agents LEARNING OBJECTIVES Define histamines and their receptor functionality Define ...
Key words: Helicobacter pylori, Meckels Diverticulum ulcer, gastroesophageal reflux disease, peptic ulcer disease. ... we have given a detailed description of ulcer and its causative factors along with medicinal plants with antiulcer potency. ... The commercially available antiulcer drugs usually have various side effects. Due to these side effects, there is a need to ... less or no side effects and medicinal plants have always been the main source of new drugs for the treatment of gastric ulcer. ...
Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and ... was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of ... associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. ... There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) ...
Pasniciuc on gas x anti ulcer agent: It has no value for ulcer treatment. ... Ulcer (Definition) An ulcer is a discontinuity or a break in a body membrane that impedes the normal functioning of the organ ... Ulcers: H.pylori can cause gastritis and stomach ulcers so perhaps if you were symptomatic they want to decrease the acidity to ... Ulcers are further classified by their location. Ulcers are usually caused by infections, excessive acid production, stress, ...
The benzimidazole compound omeprazole, used widely for the treatment of peptic ulcer disease, inhibits the growth of Leishmania ... Antileishmanial Activity of the Antiulcer Agent Omeprazole. Suping Jiang, Juliana Meadows, Steven A. Anderson, Antony J. ... Antileishmanial Activity of the Antiulcer Agent Omeprazole. Suping Jiang, Juliana Meadows, Steven A. Anderson, Antony J. ... Antileishmanial Activity of the Antiulcer Agent Omeprazole. Suping Jiang, Juliana Meadows, Steven A. Anderson, Antony J. ...
Group E: 20 mg/kg Omeprazole + Ulcer. Group F: 20 mg/kg ranitidine + ulcer. Group G: 100 mg/kg cimetidine + ulcer. At the end ... Ulcer alone; Group B: 20 mg/kg Rabeprazole + Ulcer; Group C: 20 mg/kg Rabeprazole + 20 mg/kg Ranitidine + Ulcer. Group D: ... Ulcers were induced via oral administration of a mixture acid alcohol (Ethanol and HCl). Group A: ... Key words: Ulcer, acid-alcohol, Rabeprazole, Ranitidine, Omeprazole, Ranitidine, Wistar rats. ...
Daniel Vasella) concerning the new anti-ulcer agent, CS-526, an Acid Pump Antagonist (APA) that is currently under development ... Tie-up With Novartis AG Concerning New Anti-ulcer Agent CS-526. ... Basic Policy for Anti-Social Forces *Ube Group Compliance ... It has anti-Helicobacter pylori action, and according to the findings of non-clinical tests, it offers superior benefits in ...
Treating Zollinger-Ellison syndrome, ulcers caused by nonsteroidal anti-inflammatory drugs and gastroesophageal reflux disease ... Antiulcer Agents - Nexium Is a Top Performer. 4th May, 2014. Antiulcer therapies have made major advances in recent years with ... but the primary uses of the medication are treating GERD or acid reflux and stomach ulcers caused by anti-inflammatory ... Patients who took 40 mg and 20 mg of esomeprazole averaged ulcers in 1.5-percent of cases for 2,426 patients who took the ...
The Compounds 1e, 1j and 1d exhibited good gastro protective action as indicated by their low ulcer score. Overall, 1e was ... Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents. Author(s): ... Title:Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents ... Overall, 1e was obtained as lead compound with promising anti-inflammatory, antioxidant and antiulcer activities. ...
... as flavonoids and tannins for the treatment of peptic ulcer and it is evident that plant extracts have significant antiulcer ... Peptic ulcer is a gastro intestinal disorder due to an imbalance between the aggressive factors like acid, pepsin, Helicobacter ... Medicinal Plants as Anti-Ulcer Agents. Author(s): RT Lakshmi Srinivas¹*, S Mohana Lakshmi¹, S Neelufar Shama¹, G Koteswara ... Medicinal Plants as Anti-Ulcer Agents. J Pharmacogn Phytochem 2013;2(4):91-97. ...
For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer ... treatment with a reduced dose of nizatidine is effective as maintenance therapy following healing of active duodenal ulcers. ...
Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers; hypersecretory (increased acid secretion) ... For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). ... is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and ...
Gastric Ulcer Peptic Ulcer Gastrointestinal Diseases Digestive System Diseases Lansoprazole Anti-Ulcer Agents Gastrointestinal ... Anti-Ulcer Agents. Gastrointestinal Agents. Proton Pump Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological ... Peptic Ulcer. Gastrointestinal Diseases. Stomach Ulcer. Ulcer. Digestive System Diseases. Pathologic Processes. Duodenal ... Has any gastric ulcer of ,2 cm in any diameter or with ,3 separate gastric ulcers in total as evident by endoscopy within 14 ...
Fibrin Modulating Agents. Cytochrome P-450 CYP2C19 Inhibitors. Cytochrome P-450 Enzyme Inhibitors. Enzyme Inhibitors. Anti- ... Recurrent Peptic Ulcer [ Time Frame: 6 months ]. Number of participants with recurrent peptic ulcer within 6 months ... Ulcer. Peptic Ulcer. Pathologic Processes. Duodenal Diseases. Intestinal Diseases. Gastrointestinal Diseases. Digestive System ... Purinergic Agents. Neurotransmitter Agents. Molecular Mechanisms of Pharmacological Action. Physiological Effects of Drugs. ...
Anti-Ulcer Agents. Gastrointestinal Agents. Proton Pump Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological ... Ulcer. Stomach Ulcer. Pathologic Processes. Peptic Ulcer. Duodenal Diseases. Intestinal Diseases. Gastrointestinal Diseases. ... Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. This study looks at the prevention of ... No gastric or duodenal ulcer on baseline endoscopy.. *A clinical diagnosis of a chronic condition that requires daily NSAID ...
Anti-Ulcer Agents / economics * Anti-Ulcer Agents / therapeutic use* * Critical Illness * Enteral Nutrition ... Pathophysiology and prophylaxis of stress ulcer in intensive care unit patients J Crit Care. 2005 Mar;20(1):35-45. doi: 10.1016 ... Many clinicians prescribe intermittent infusions of H 2 RAs for stress ulcer prophylaxis, a practice that has not been approved ... The prophylactic regimen chosen to prevent stress ulcer bleeding should take into account the risk factors and underlying ...
Anti-Ulcer Agents. Gastrointestinal Agents. Proton Pump Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological ... Stomach Ulcer. Duodenal Ulcer. Ulcer. Pathologic Processes. Peptic Ulcer. Duodenal Diseases. Intestinal Diseases. ... Gastric Ulcer Duodenal Ulcer Rheumatoid Arthritis Osteoarthritis Lumbago Drug: Esomeprazole 20 mg Phase 3 ... for the Prevention of Gastric and/or Duodenal Ulcers Associated With Daily Nonsteroidal Anti-inflammatory Drug (NSAID) Use. ...
Supplier and Exporter of Anti Ulcer, GIT Agent & Antacid located in Surat, Gujarat, India. ... Troxipide is a systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting ... Ranitidine Injection is a medicine that is used for the treatment of Benign Duodenal Ulcer, Gastric Ulcer, Inflammation Of The ... Cimetidine Tablet is used for Excess Acid Secretion In the Stomach, Heartburn, Ulcer Formation In the Stomach, Ulcer Formation ...
Manufacturer of Antiulcer Agents API - Ecabet Sodium offered by Triveni Interchem Private Limited (Group Of Triveni Chemicals ... Stomach Ulcer API. Osteoporosis API. Puffiness API. API 5. API 4. Anticonvulsant API. ... Antiulcer Agents API. Offering you a complete choice of products which include ecabet sodium. ... Anti-Infectives API. Antiulcer Agents API. Type 2 Diabetes API. Schizophrenia API. Overactive Bladder API. Anaesthetic API. ...
... to treat the peptic ulcer, compounds with phosphodiesterase 5 inhibitor were not tested before Dr. Karakaya of Zonguldak ... Karaelmas University-who have reported that Vardenafil can be used to treat the NSAID-induced gastric ulcer. As per the claim ...
Methionine in itself has not been demonstrated as effective for treating peptic and duodenal ulcers. Its proponents claim that ... have further substantiated the claim that it can be used to treat peptic and duodenal ulcers.. Acetaminophen is a pain reliever ...
Anti-Ulcer Agents Research. [x] Remove Focus on Anti-Ulcer Agents. Filter by Study Type. Animal Study. ... Medicating with anti-histamines isnt a healthy option and can leave many feeling drowsy and fatigued. Luckily there are ... The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin.Aug ... natural remedies that are making waves for their powerful anti-histamine-like effects and abilities to suppress seasonal ...
Ulcers can develop in the esophagus, stomach or duodenum. Peptic ulcer (PU) disease represents a worldwide health problem due ... Out of this screening methods some are used widely such as pylorus ligation, NSAID induced ulcer, stress induced ulcer by ... In this present review we discuss the various screening methods used for the antiulcer drug development. ... Researchers develop various screening methods for the study of antiulcer drug development. ...
Anti-Asthmatic Agents, Anti-Inflammatory Agents, Anti-Ulcer Agents, Anticonvulsants, Antihypertensive Agents, Antimicrobial, ... Musa sapientum peel extracts have anti-ulcer and ulcer healing potential.Jun 30, 2013. ... Ulcers hurt! That burning, gnawing pain will make you want to reach for your ulcer meds fast. But, wait a minute. Not so fast. ... Diseases : Asthma, Cancers: All, Hyperlipidemia, Hypertension, Inflammation, Pain, Ulcers. Pharmacological Actions : Analgesics ...
... one week of antibacterial therapy without acid suppression heals the ulcers as well as omeprazole and reduces the rate of their ... pylori infection and gastric ulcers unrelated to the use of nonsteroidal antiinflammatory drugs, ... Anti-Bacterial Agents / therapeutic use* * Anti-Ulcer Agents / therapeutic use* * Confidence Intervals ... pylori infection and gastric ulcers unrelated to the use of nonsteroidal agents. ...
Pharmacological Actions : Anti-Ulcer Agents. [+] Hesperidin has therapeutic value in the treatment of recurrent aphthous ... Coeliac disease: oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.Jan 31, 2008. ... Myrtle is effective in decreasing the size of ulcers, pain severity and the level of erythema and exudation, and improving the ... Topical application of curcumin enhanced the wound-healing process of oral ulcer in an animal model.Sep 28, 2015. ...
... have a similar effect on preventing bleeding from artificial ulcers. An objective of this stud ... Anti-Ulcer Agents / therapeutic use*. Cimetidine / therapeutic use*. Female. Gastroscopy. Histamine H2 Antagonists / ... 0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Histamine H2 Antagonists; 0/Proton Pumps; 32828355LL/ ... Peptic Ulcer Hemorrhage / etiology, prevention & control*. Postoperative Complications. Prospective Studies. Proton Pumps / ...
Anti-Ulcer Agents; thiazolidinone derivatives Subjects:. 600 Technology , 01 Medical sciences , 15 Pharmacology. 500 Natural ... Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study. ... Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study. Letters in Drug Design ...
Compare risks and benefits of common medications used for NSAID-Induced Gastric Ulcer. Find the most popular drugs, view ... About NSAID-Induced Gastric Ulcer: Gastric Ulcers may be caused by non-steroidal anti-inflammatory agents. ... Drugs Used to Treat NSAID-Induced Gastric Ulcer. The following list of medications are in some way related to, or used in the ... Medications for NSAID-Induced Gastric Ulcer. *Medication List. ...
Anti-Ulcer Agents. Gastrointestinal Agents. Disclaimer: Information presented in this database is not meant as a substitute for ...
  • Treating Zollinger-Ellison syndrome, ulcers caused by nonsteroidal anti-inflammatory drugs and gastroesophageal reflux disease,[3] Nexium decreases stomach acid, prevents esophageal damage from acid back-flow and stops recurrences of stomach ulcers caused by H. pylori bacteria. (planetdrugsdirect.com)
  • Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. (clinicaltrials.gov)
  • What are nonsteroidal anti-inflammatory drugs (NSAIDs)? (medicinenet.com)
  • Nonsteroidal anti-inflammatory drugs ( NSAIDs ) are commonly prescribed medications for the inflammation of arthritis and other body tissues, such as in tendinitis and bursitis . (medicinenet.com)
  • The most common causes are bacteria and use of nonsteroidal anti-inflammatory drugs ( NSAIDs ). (medicalnewstoday.com)
  • A cohort of 1000 hypothetical patients presenting to a physician with symptoms suggestive of peptic ulcer disease who were not concurrently taking nonsteroidal anti-inflammatory drugs. (acpjc.org)
  • Cyanocobalamin demonstrates therapeutic activity against aphthous ulcers (canker sores). (greenmedinfo.com)
  • In conclusion, the results of this study have indicated that lansoprazole, PD- 136450 and TGFct are potent antisecretory and antiulcer agents which have great therapeutic importance. (uclan.ac.uk)
  • For example, bacteria that cause disease are agents of the specific diseases they cause, and medicine is a therapeutic agent. (tabers.com)
  • Anti-ulcer compositions are disclosed having therapeutic agents dispersed in a soluble matrix formed by melt spinning the therapeutic agent with a carrier and hydrogel. (google.com.au)
  • One embodiment includes use of gastric irritating bio-affecting agents in which case the composition is preventative as well as therapeutic. (google.com.au)
  • Nature is an attractive source of new therapeutic candidate compounds as a tremendous chemical diversity is found in millions of species of plants, animals, marine organisms, and microorganisms as potential medicinal agents. (springer.com)
  • Furthermore, gum arabic is reported to prevent development of indomethacin induced gastric ulcers in rats [ 10 ]. (alliedacademies.org)
  • Abbas AM, Sakr HF (2013) Effect of selenium and grape seed extract on indomethacin-induced gastric ulcers in rats. (springer.com)
  • Will Pepcid or Zantac (ranitidine) relieve the gas caused by my anti-inflammatory medication Diclofenac? (healthtap.com)
  • Group C: 20 mg/kg Rabeprazole + 20 mg/kg Ranitidine + Ulcer. (academicjournals.org)
  • 0.05) in the volume of gastric acid secreted for the groups that received the ranitidine and rabeprazole compared to group A (ulcer alone). (academicjournals.org)
  • This research showed that groups treated with a combination of rabeprazole and ranitidine has a better potency for the management of gastric ulcer patients. (academicjournals.org)
  • Ranitidine Injection is a medicine that is used for the treatment of Benign Duodenal Ulcer, Gastric Ulcer, Inflammation Of The Esophagus, Acid Peptic Disease and other conditions. (medzeellifescience.com)
  • The initial study deals with the comparison of the three compounds with omeprazole and ranitidine in terms of their ability to inhibit acid secretion and their activity in a range of experimental ulcer models. (uclan.ac.uk)
  • A number of drugs including proton pump inhibitors (Omeprazole) and histamine (H2) receptor antagonists (Ranitidine) are available for the treatment of peptic ulcer, but these drugs have shown incidence of relapses, side effects, and drug interactions. (scirp.org)
  • Ranitidine injection is used for patients with hypersecretory conditions, intractable ulcers, or for patients who cannot receive oral therapy. (ashp.org)
  • 2.Cimetidine, Ranitidine or Famotidine may be administered to treat peptic ulcers or hypersecretory states. (pharmainfo.net)
  • Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. (bmj.com)
  • OBJECTIVE: To evaluate the prophylactic effect of ranitidine 150 mg twice daily in patients requiring one of the following non-steroidal anti-inflammatory drugs: naproxen, piroxicam, diclofenac, and indomethacin. (bmj.com)
  • INTERVENTIONS: Ranitidine 150 mg twice daily or placebo (plus the selected non-steroidal anti-inflammatory drug) was prescribed within five days after the baseline endoscopy for two consecutive periods of four weeks. (bmj.com)
  • Patients with a history of peptic ulcer were particularly susceptible to recurrent ulceration, against which ranitidine offered some protection. (bmj.com)
  • CONCLUSIONS: Ranitidine 150 mg twice daily significantly reduced the incidence of duodenal ulceration but not gastric ulceration when prescribed concomitantly with one of four commonly used non-steroidal anti-inflammatory drugs. (bmj.com)
  • Ehsanullah R. S. , Page M. C. , Tildesley G. , Wood J. R. . Prevention of gastroduodenal damage induced by non-steroidal anti-inflammatory drugs: controlled trial of ranitidine. (bmj.com)
  • The influence of gum arabic on the antiulcer activity of ranitidine, a known antiulcer drug was also evaluated. (alliedacademies.org)
  • It also produced a significant protection in the development of the gastric ulcers in other gastric ulcer models and also potentiated the antiulcer effect of ranitidine. (alliedacademies.org)
  • The study also determined the influence gum arabic on the antiulcer effect of ranitidine, a histamine receptor (H2-receptor) blocker. (alliedacademies.org)
  • Approximately 15% of patients on long-term treatment with NSAIDs develop a peptic ulcer (ulceration of the stomach or duodenum). (medicinenet.com)
  • Patients with heart disease who are taking aspirin for prevention of heart attacks also are at risk, and the risk of bleeding ulcers doubles if aspirin is combined with other NSAIDs. (medicinenet.com)
  • By blocking the Cox-1 enzyme and disrupting the production of prostaglandins in the stomach, NSAIDs can cause ulcers and bleeding. (medicinenet.com)
  • Some NSAIDs have less effect on prostaglandins in the stomach than others, and, therefore, may have a lower risk of causing ulcers, but the increased risk of ulcers still exists. (medicinenet.com)
  • The chronic administration of non-steroidal antiinflammatory drugs (NSAIDs) is associated with the development of gastrointestinal adverse effects, such as gastric erosions, gastritis or duodenum ulcers (8, 24, 34) . (scielo.br)
  • However, more recently the focus has been on the bacteria Helicobacter pylori and non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen. (iherb.com)
  • It's also given to help prevent ulcers when an animal is receiving aspirin or NSAIDs. (medi-vet.com)
  • Antisecretory drugs are also the treatment of choice for NSAID- or aspirin-related peptic ulcers and are useful as preventive therapy in chronic users of NSAIDs and low-dose aspirin as antiplatelet therapy. (springer.com)
  • Yap PR, Goh KL (2015) Non-steroidal anti-inflammatory drugs (NSAIDs) induced dyspepsia. (springer.com)
  • Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophageal reflux disease. (academicjournals.org)
  • Among treatments for gastroesophageal reflux disease and stomach ulcers caused by excessive production of gastric acid, esomeprazole is one of the most popular and effective medications available. (planetdrugsdirect.com)
  • For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). (pharmacycode.com)
  • Famotidine, a competitive histamine H 2 -receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. (pharmacycode.com)
  • These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease . (rug.nl)
  • Numerous studies over the years have found DGL to be an effective anti-ulcer compound. (iherb.com)
  • It is an effective anti-ulcer agent and also has oxytocic properties. (nih.gov)
  • H. pylori and peptic ulcers. (academicjournals.org)
  • It has anti-Helicobacter pylori action, and according to the findings of non-clinical tests, it offers superior benefits in comparison with existing drugs. (ube-ind.co.jp)
  • TAK-438 is being tested to treat people who have stomach ulcers and also may or may not have Helicobacter pylori (HP) infection. (clinicaltrials.gov)
  • There is a strong association between infection with Helicobacter pylori and gastric ulcers that are unrelated to the use of nonsteroidal antiinflammatory medications. (nih.gov)
  • We studied the efficacy of antibacterial therapy without medication to suppress gastric acid for the treatment of patients with H. pylori infection and gastric ulcers unrelated to the use of nonsteroidal agents. (nih.gov)
  • Patients with gastric ulcers seen on endoscopy and with H. pylori infection confirmed by smear or culture were randomly assigned to receive either a one-week course of antibacterial agents (120 mg of bismuth subcitrate, 500 mg of tetracycline, and 400 mg of metronidazole, each given orally four times a day) or a four-week course of omeprazole (20 mg orally per day). (nih.gov)
  • H. pylori was detected in the 1 patient with a recurrent ulcer who had received antibacterial treatment and in 10 of the 12 patients with recurrent ulcers who had received omeprazole. (nih.gov)
  • In patients with H. pylori infection and gastric ulcers unrelated to the use of nonsteroidal antiinflammatory drugs, one week of antibacterial therapy without acid suppression heals the ulcers as well as omeprazole and reduces the rate of their recurrence. (nih.gov)
  • Since H. pylori bacteria is a common cause of ulcers, eradication of the bacteria with a combination of antibiotics also may promote ulcer healing. (medicinenet.com)
  • The earliest theory, known as the bacteriological hypothesis, suggests that some bacteria or viruses such as streptococcus sanguis , Streptococcus viridians , Helicobacter pylori , Herpes simplex , and Epstein-Barr between other microorganisms are the main etiologic agents responsible for the development of RAU. (hindawi.com)
  • The available treatments for peptic ulcer are essentially based on gastric acid suppression with antisecretory drugs and the eradication of H. pylori infection. (springer.com)
  • Proton pump inhibitor (PPI)-based triple therapies for 7 days are highly effective for the cure of H. pylori -positive peptic ulcers as well as for reducing ulcer recurrence. (springer.com)
  • Pilotto A, Franceschi M, Di Mario F. Helicobacter pylori-associated peptic ulcer disease in elderly patients. (springer.com)
  • Pilotto A. Helicobacter pylori-associated peptic ulcer disease in older patients: current management strategies. (springer.com)
  • Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients. (springer.com)
  • To estimate the economic effects of 2 immediate endoscopy and 3 initially noninvasive diagnostic and treatment strategies for peptic ulcer and Helicobacter pylori in patients with symptoms suggestive of peptic ulcer disease. (acpjc.org)
  • The purpose of this study is to assess the Safety and tolerability of D961H (Esomeprazole) 20 mg once daily for up to 52 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily nonsteroidal anti-inflammatory drug (NSAID) therapy by evaluating AE, clinical laboratory value and vital signs. (clinicaltrials.gov)
  • Though there are many compounds with different mode of action have been tested (and some of them are being used) to treat the peptic ulcer, compounds with phosphodiesterase 5 inhibitor were not tested before Dr. Karakaya of Zonguldak Karaelmas University -who have reported that Vardenafil can be used to treat the NSAID-induced gastric ulcer. (med-chemist.com)
  • Out of this screening methods some are used widely such as pylorus ligation, NSAID induced ulcer, stress induced ulcer by immobilization and water immersion, erosion by ethanol and acetic acid. (inventi.in)
  • Taking blood thinning medications ( anticoagulants ), such as warfarin ( Coumadin ), and heparin , does not cause NSAID -related ulcers, but rather they increase bleeding if NSAID-induced ulcers occur. (medicinenet.com)
  • A prior history of ulcers is the most important predictor of NSAID-induced ulcers. (medicinenet.com)
  • Capsicum annum L lyophilized fruit extract has a gastroprotective effect in experimentally-induced gastric ulcer in rats. (greenmedinfo.com)
  • the present study was envisaged to explore its effect on stomach in normal animals and on different experimentally induced gastric ulcer models in rats. (alliedacademies.org)
  • Can children use an anti acid like Tums (calcium carbonate) for frequent eructation with stomach contents coming in mouth? (healthtap.com)
  • Ulcers were induced via oral administration of a mixture acid alcohol (Ethanol and HCl). (academicjournals.org)
  • At the end of the treatment and induction, volume of gastric acid secreted, pH values, Ulcer index, stomach and body weights were analyzed statistically. (academicjournals.org)
  • Chairman and CEO: Dr. Daniel Vasella) concerning the new anti-ulcer agent, CS-526, an Acid Pump Antagonist (APA) that is currently under development, and its backup compound. (ube-ind.co.jp)
  • Your doctor might prescribe Nexium to treat various conditions , but the primary uses of the medication are treating GERD or acid reflux and stomach ulcers caused by anti-inflammatory medications . (planetdrugsdirect.com)
  • For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer. (pharmacycode.com)
  • Many clinicians prescribe intermittent infusions of H 2 RAs for stress ulcer prophylaxis, a practice that has not been approved for this indication and may not provide the necessary degree or duration of acid suppression required to prevent stress ulcer-related bleeding. (nih.gov)
  • Gastric ulcer is corrosive action of acid on the mucosa of the upper gastrointestinal tract. (inventi.in)
  • The second phase of the study deals with the activity of the three compounds against gastric ulcers induced by acid hypersecretion, indomethacin and stress. (uclan.ac.uk)
  • Acute gastric ulcers were induced in rats by the oral administration of acetylsalicylic acid. (scielo.br)
  • The gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by chemical agent with a maximum of 99.44% curation (250 mg.kg -1 body weight) in acetylsalicylic acid-induced ulcers. (scielo.br)
  • Neutralization of gastric acid with healing of ulcers and decrease in associated pain. (thefreedictionary.com)
  • The pH of gastric acid (1 to 3) would eat an ulcer right through the skin. (iherb.com)
  • In addition, the constant renewing of intestinal cells and the secretion of factors which neutralize the acid when it comes in contact with the stomach and intestinal linings also protect against ulcer formation. (iherb.com)
  • Contrary to popular opinion, over-secretion of gastric acid output is rarely a factor in gastric ulcers. (iherb.com)
  • In fact, patients with gastric ulcers tend to secrete normal or even reduced levels of gastric acid. (iherb.com)
  • In duodenal ulcer patients, almost half have increased gastric acid output. (iherb.com)
  • Even with an increase in gastric acid output, under normal circumstances, there are enough protective factors to prevent either gastric or duodenal ulcer formation. (iherb.com)
  • The activity was evaluated using induced gastric ulcer models (acetic acid and ethanol-induced gastric lesions in NEM or L-NAME pre-treated mice, and by ischemia/reperfusion). (biomedcentral.com)
  • Antiulcer agents and acid suppressants. (ashp.org)
  • It is known that one of the results of the blockade of the action ofhistamine at the H-2 receptor is the inhibition of the secretion of gastric acid and a compound which possesses this ability is therefore useful in the treatment of peptic ulcers and other conditions caused or exacerbated by gastric acidity. (patentgenius.com)
  • If the mucus layer is worn away and stops functioning effectively, the acid can damage the stomach tissue, causing an ulcer. (medicalnewstoday.com)
  • The antiulcer study was carried out in acetic acid induced chronic gastric, pylorus ligation induced gastric, ethanol induced gastric, stress induced gastric, and indomethacin induced gastric ulcers. (alliedacademies.org)
  • The Antiulcer Activities effects of myrrh or Commiphora molmol extract (CME) were assessed in rats. (scirp.org)
  • CME induced an antiulcer effect manifested by decreased volume and total acidity of gastric juice and increased mucus content and percentages of protec-tion from ulcer as well as partial amelioration of gross and histopathological lesions seen in stomach of ulcerated rats. (scirp.org)
  • In conclusion, the results denote that Commiphora molmol extract possess antiulcer effects in rats. (scirp.org)
  • The present study was designed to investigate (CME) extract on healing of peptic ulcer in rats inflicted with aspirin-induced gastric ulcer. (scirp.org)
  • The present study was undertaken to determine the effect of gum arabic on gastric ulcers in rats. (alliedacademies.org)
  • The current study aimed to investigate the antiulcer effect of moringa leaves and its aqueous extract on pro-inflammatory cytokines and inflammatory mediators in ulcerative rats. (springer.com)
  • Rats were treated with either moringa leaves (10%) or moringa extract (300 mg/kg body weight) for 4 weeks then treated with a single dose of aspirin to induce gastric ulcer. (springer.com)
  • This study confirms the gastro-protective influence of moringa leaves and its extract on aspirin-induced ulcer in rats as manifested by its significant reduction in inflammatory cytokines and normalization of gastric mucosal mucin and NO level. (springer.com)
  • We plan to enroll 300 clopidogrel users without baseline gastroduodenal ulcer at initial endoscopy. (clinicaltrials.gov)
  • No gastric or duodenal ulcer on baseline endoscopy. (clinicaltrials.gov)
  • PATIENTS--297 patients with rheumatoid arthritis or osteoarthritis over the age of 18 without lesions in the stomach and duodenum at baseline endoscopy (after one week without taking non-steroidal anti-inflammatory drugs). (bmj.com)
  • The cost-effectiveness advantage of noninvasive strategies relative to immediate endoscopy strategies were sensitive to 2 variables: the cost of the endoscopy and the probability of recurrent symptoms in patients without an ulcer. (acpjc.org)
  • The benzimidazole compound omeprazole, used widely for the treatment of peptic ulcer disease, inhibits the growth of Leishmania donovani , the causative agent of visceral leishmaniasis. (asm.org)
  • Group E: 20 mg/kg Omeprazole + Ulcer. (academicjournals.org)
  • At nine weeks, ulcer healing was confirmed in 43 of the patients receiving antibacterial therapy and in 37 of those receiving omeprazole (P = 1.0). (nih.gov)
  • One year after treatment, recurrent gastric ulcers were detected in 1 of 22 patients (4.5 percent) in the antibacterial-treatment group and in 12 of 23 (52.2 percent) in the omeprazole group (P = 0.001). (nih.gov)
  • G3) pretreated with Omeprazole (antiulcer drug) and groups (4), (5) and (6) were pretreated with CME at 125, 250 and 500 mg/kg b.wt, respective-ly for 2 weeks. (scirp.org)
  • Troxipide is a systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum. (medzeellifescience.com)
  • This study enabled us to assess the extent to which antisecretory activity per se compared with other actions such as wound healing (TGFa) or anxiolytic activity (PD-136450) contribute to ulcer healing. (uclan.ac.uk)
  • It was concluded that gum arabic have beneficial effect in preventing and healing of gastric ulcers due to both gastric antisecretory and cytoprotective effects. (alliedacademies.org)
  • All patients had symptoms severe enough to justify an empiric course of antisecretory agents and had no previously documented peptic ulcer disease. (acpjc.org)
  • Treatment of peptic ulcer disease. (academicjournals.org)
  • Peptic ulcer disease (PUD) is considered as one of the common diseases in the world. (phytojournal.com)
  • The prophylactic regimen chosen to prevent stress ulcer bleeding should take into account the risk factors and underlying disease state of individual patients to provide the best therapy to those most likely to benefit. (nih.gov)
  • Peptic ulcer (PU) disease represents a worldwide health problem due to morbidity, mortality and economic loss. (inventi.in)
  • Coeliac disease: oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. (greenmedinfo.com)
  • Corneal ulcers are a common human eye disease. (wikipedia.org)
  • Immune-mediated eye disease can cause ulcers at the border of the cornea and sclera. (wikipedia.org)
  • Probably a failing of the epithelial barrier must occur in parallel with an infection agent for activation of the disease. (hindawi.com)
  • Constipation limits use alone in the treatment of ulcer disease. (thefreedictionary.com)
  • In treatment of severe ulcer disease, guaiac stools, and emesis, monitor pH of gastric secretions. (thefreedictionary.com)
  • Gastric ulcer is a common disease with multiple etiologies. (biomedcentral.com)
  • The main goals for treating peptic ulcer disease in old age are to reduce recurrence of the disease and to prevent complications, especially bleeding and perforation. (springer.com)
  • Age, sex, arthritic disease, and type of non-steroidal anti-inflammatory drug used were comparable in the two treatment groups. (bmj.com)
  • Alternative management strategies for patients with suspected peptic ulcer disease. (acpjc.org)
  • In patients with symptoms suggesting peptic ulcer disease, the estimated costs per ulcer cured and per patient treated were lower when noninvasive management strategies were used. (acpjc.org)
  • A government-sponsored trial and clinical trials in Asia have concluded that both methods of treatment reduce rebleeding within 30 days after endoscopic treatments of peptic ulcers. (planetdrugsdirect.com)
  • Effect of a proton pump inhibitor or an H2-receptor antagonist on prevention of bleeding from ulcer after endoscopic submucosal dissection of early gastric cancer: a prospective randomized controlled trial. (biomedsearch.com)
  • OBJECTIVES: With conventional methods of endoscopic mucosal resection for early gastric cancer (EGC), proton pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs) have a similar effect on preventing bleeding from artificial ulcers. (biomedsearch.com)
  • High-dose pantoprazole continuous infusion is superior to somatostatin after endoscopic hemostasis in patients with peptic ulcer bleeding. (ashp.org)
  • Pantoprazole infusion as adjuvant therapy to endoscopic treatment in patients with peptic ulcer bleeding: prospective randomized controlled trial. (ashp.org)
  • Absence of abdominal pain in older persons with endoscopic ulcers: a prospective study. (springer.com)
  • Corneal ulcer is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. (wikipedia.org)
  • In developing countries, children afflicted by Vitamin A deficiency are at high risk for corneal ulcer and may become blind in both eyes, which may persist lifelong. (wikipedia.org)
  • In ophthalmology, a corneal ulcer usually refers to having an infectious cause while the term corneal abrasion refers more to physical abrasions. (wikipedia.org)
  • Sensitivity to light (photophobia) is also a common symptom of corneal ulcer. (wikipedia.org)
  • Many micro-organisms cause infective corneal ulcer. (wikipedia.org)
  • Fungal keratitis causes deep and severe corneal ulcer. (wikipedia.org)
  • Chlamydia trachomatis can also contribute to development of corneal ulcer. (wikipedia.org)
  • These include Rheumatoid arthritis, rosacea, systemic sclerosis which lead to a special type of corneal ulcer called Mooren's ulcer. (wikipedia.org)
  • Melting ulcers are a type of corneal ulcer involving progressive loss of stroma in a dissolving fashion. (wikipedia.org)
  • Several high-profile clinical studies have tested how well oral and intravenous esomeprazole works for patients who have bleeding peptic ulcers . (planetdrugsdirect.com)
  • Esomeprazole reduced occurrences of peptic ulcers significantly. (planetdrugsdirect.com)
  • Patients who took 40 mg and 20 mg of esomeprazole averaged ulcers in 1.5-percent of cases for 2,426 patients who took the medicine for 26 weeks. (planetdrugsdirect.com)
  • Esomeprazole with clopidogrel reduces peptic ulcer recurrence, compared with clopidogrel alone, in patients with atherosclerosis. (clinicaltrials.gov)
  • For example, the -profen in ibuprofen indicates "anti-inflammatory agents," the -prazole in esomeprazole indicates "antiulcer, benzimidazole derivatives," and the -mab in trastuzumab indicates that the drug is a monoclonal antibody. (drugpatentwatch.com)
  • Gastric ulcer is a deep defect in the gastric (stomach) wall penetrating the entire mucosal thickness and muscaris mucosa (Adeniyi et al. (academicjournals.org)
  • An ulcer in the gastrointestinal tract is a deep necrotic region penetrating the entire mucosal thickness and muscularis mucosae. (academicjournals.org)
  • Ulcer healing is an active process of filling the mucosal defect with proliferating and migrating epithelial and tissue cells. (academicjournals.org)
  • Methods of treating mucosal ulcer-bearing tissue and preparing the matrix are also disclosed. (google.com.au)
  • Peskar BM (2005) Role of cyclooxygenase isoforms in gastric mucosal defense and ulcer healing. (springer.com)
  • Even though many of these patients with ulcers do not have symptoms and are unaware of their ulcers, they are at risk of developing serious ulcer complications, such as bleeding or perforation of the stomach. (medicinenet.com)
  • The overall approach to the geriatric patient should include a comprehensive geriatric assessment that ensures multidimensional evaluation of the patient in order to better define the clinical risk of adverse outcomes in the older patient with peptic ulcer and its complications. (springer.com)
  • The designed compounds were synthesized by Claisen Schmidt condensation and evaluated for anti-inflammatory, antioxidant and antiulcer activities. (eurekaselect.com)
  • All the compounds were evaluated for their anti-inflammatory (carrageenan-induced rat paw edema assay), antioxidant (inhibition of lipid peroxidation) and antiulcer activity (indomethacin-induced gastric damage). (eurekaselect.com)
  • Of 10 compounds screened, compounds 1e and 1d exhibited promising anti-inflammatory activity with 68-70% inhibition at 100mg/kg , inhibition of lipid peroxidation with IC50 2.47 & 3.1 μg/ml respectively. (eurekaselect.com)
  • The Compounds 1e, 1j and 1d exhibited good gastro protective action as indicated by their low ulcer score. (eurekaselect.com)
  • Yes, a healthy diet, anti-inflammatory vitamins and related compounds may help you recover from everything, ranging from the inevitable daily wear and tear of our stressful lives to a debilitating injury, but no legally available supplement has actively promoted wound, bone and overall tissue healing. (ageforce.com)
  • These compounds may be subjected to further investigations for the development of antiulcer drugs. (biomedsearch.com)
  • To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. (bmj.com)
  • Aloe Vera gel is a beneficial treatment and cost effective for patients with chronic ulcers. (greenmedinfo.com)
  • These agents are also used to treat patients with wasting illnesses. (tabers.com)
  • Cheney (13) verified that the patients who utilized the fresh cabbage juice obtained a healing action for gastric disorders, particularly for the peptic ulcer, presenting healing effects of the lesion. (scielo.br)
  • As a group, patients with duodenal ulcers have twice as many parietal cells in their stomach compared to people without ulcers. (iherb.com)
  • Lowering of phosphate levels in patients with chronic renal failure.Adjunctive therapy in the treatment of peptic, duodenal, and gastric ulcers.Hyperacidity, indigestion, reflux esophagitis. (thefreedictionary.com)
  • conversely, the rates of gastric and duodenal ulcer hospitalization and mortality remain very high in older patients. (springer.com)
  • The aim of this article is to report the available data on clinical efficacy and tolerability of peptic ulcer treatments in elderly patients and provide recommendations for their optimal use in this special population. (springer.com)
  • The authors developed clear recommendations about the advantages of a noninvasive approach to managing patients suspected of having a peptic ulcer. (acpjc.org)
  • This study has presented the review of commonly used anti-ulcer plants which are used for the treatment or prevention of peptic ulcers and the other reported activities of these plants. (phytojournal.com)
  • The aim of the prospective, randomized study is to investigate the efficacy of PPI in prevention of ulcer recurrence for clopidogrel users. (clinicaltrials.gov)
  • Peptic ulcer and non-steroidal anti-inflammatory agents. (bmj.com)
  • A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. (bmj.com)
  • But its anti inflammatory properties are probably very limited. (healthtap.com)
  • Overall, 1e was obtained as lead compound with promising anti-inflammatory, antioxidant and antiulcer activities. (eurekaselect.com)
  • Alka N. Choudhary, Arun Kumar and Vijay Juy, "Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents", Letters in Drug Design & Discovery (2012) 9: 479. (eurekaselect.com)
  • Treatment of peptic ulcer with synthetic drugs such as proton pump inhibitors, H2 receptor antagonists and other non-steroidal anti-inflammatory drugs has shown adverse effects, relapses, drug interactions. (phytojournal.com)
  • Gastric Ulcers may be caused by non-steroidal anti-inflammatory agents. (drugs.com)
  • Used in cooking for its nutritional value also has known anti-inflammatory activity. (scielo.br)
  • However, larger or deeper ulcers often require the presence of blood vessels to supply inflammatory cells. (thefullwiki.org)
  • In Chinese herbal medicine , under the name of jiang huang , the turmeric rhizome is used in many different formulas as an anti-inflammatory pain reliever, especially for shoulder pain. (encyclopedia.com)
  • The leaves have been used as an anti-inflammatory agent, for kidney pain, stomach ulcers, and digestive ailments. (drugs.com)
  • Biological effects of rebamipide include cytoprotection, wound healing, and anti-inflammatory properties that are known to be universal for a variety of tissues in addition to gastrointestinal mucosa. (dovepress.com)
  • Glucocorticoids are primarily regulated by corticotropin (ACTH) and can have anti-inflammatory effects, as well as several metabolic and immunogenic effects, on the body. (aafp.org)
  • Tanaka A, Hase S, Miyazawa T, Takeuchi K (2002) Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage. (springer.com)
  • Specifically, the development of a duodenal or gastric ulcer is a result of some factor damaging the protective factors which line the stomach and duodenum. (iherb.com)
  • Several hundred plant genera are used medicinally mainly in the form of herbal preparation in indigenous system of medicine in different countries for the treatment of ulcers. (academicjournals.org)
  • Literatures suggest that polyherbal formulations of medicinal plants are considered to be potential source for the treatment of ulcers. (phytojournal.com)
  • The risk of ulcers is higher in the elderly and individuals with rheumatoid arthritis , and those also taking steroid-containing medications (for example, prednisone ), and individuals with a prior history of bleeding ulcers. (medicinenet.com)
  • The NICE guidelines recommends that everyone with a venous leg ulcer, even if healed, should be referred to a "vascular service" for venous duplex ultrasound and assessment for endovenous surgery. (wikipedia.org)
  • Venous leg ulcer pharmacological treatment options were searched in the English language from February 2020 to March 2020 using numerous databases and sites, such as PubMed. (woundsresearch.com)
  • 2 Venous leg ulcers can cultivate physical, financial, and psychological implications, such as pain and disability, 3 depression, 4,5 social isolation, 5 and decreased quality of life. (woundsresearch.com)
  • 6 Venous leg ulcers account for approximately 2% to 3% of total health care expenditure in developed countries. (woundsresearch.com)
  • Due to these side effects, there is a need to find new antiulcerogenic compound(s) with potentially less or no side effects and medicinal plants have always been the main source of new drugs for the treatment of gastric ulcer. (academicjournals.org)
  • In this review, we have given a detailed description of ulcer and its causative factors along with medicinal plants with antiulcer potency. (academicjournals.org)
  • Exploring Indian medicinal plants for anti ulcer activity. (academicjournals.org)
  • Combination of ayurvedic knowledge with modern medicine can produce better antiulcer drugs of natural origin from medicinal plants with fewer side effects. (phytojournal.com)
  • Thru the years, a great store of knowledge has been acquired concerning the development of gastric ulcer, and a broad spectrum of drugs for its treatment such as antacids, proton pump inhibitors, anticholinergics, and histamine receptor antagonists [ 5 ], has developed. (biomedcentral.com)
  • An ulcer of the cornea heals by two methods: migration of surrounding epithelial cells followed by mitosis (dividing) of the cells, and introduction of blood vessels from the conjunctiva . (thefullwiki.org)
  • The ulcer heals by the fourth day. (thefullwiki.org)
  • Moringa leaves and its extract markedly reduced ulcer index, gastric volume and total acidity. (springer.com)