Anti ulcer agents. Medical search

Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

A PEPTIC ULCER located in the DUODENUM.

Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.

An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.

Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.

Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.

A lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa.

Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.

A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).

Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

A slow-growing mycobacterium that infects the skin and subcutaneous tissues, giving rise to indolent BURULI ULCER.

A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.

Material used for wrapping or binding any part of the body.

A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.

Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. Since the procedure leaves the vagal branches to the antrum and PYLORUS intact, it circumvents gastric drainage required with truncal vagotomy techniques.

Hydrochloric acid present in GASTRIC JUICE.

The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)

A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.

Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.

An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.

Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)

Endoscopic examination, therapy or surgery of the interior of the stomach.

Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.

Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

The return of a sign, symptom, or disease after a remission.

A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Impaired digestion, especially after eating.

The characteristic three-dimensional shape of a molecule.

Control of bleeding performed through the channel of the endoscope. Techniques include use of lasers, heater probes, bipolar electrocoagulation, and local injection. Endoscopic hemostasis is commonly used to treat bleeding esophageal and gastrointestinal varices and ulcers.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.

Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.

Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.

A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.

A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.

The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.

Gastrointestinal symptoms resulting from an absent or nonfunctioning pylorus.

Antibodies produced by a single clone of cells.

A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.

Pathological processes in the ESOPHAGUS.

A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.

Elements of limited time intervals, contributing to particular results or situations.

Evaluation of the nature and extent of nursing problems presented by a patient for the purpose of patient care planning.

Equipment on which one may lie and sleep, especially as used to care for the hospital patient.

A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.

Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.

A variety of surgical reconstructive procedures devised to restore gastrointestinal continuity, The two major classes of reconstruction are the Billroth I (gastroduodenostomy) and Billroth II (gastrojejunostomy) procedures.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.

Use of plants or herbs to treat diseases or to alleviate pain.

A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)

A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).

The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)

A nucleoside consisting of the base guanine and the sugar deoxyribose.

A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.

Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

Material, usually gauze or absorbent cotton, used to cover and protect wounds, to seal them from contact with air or bacteria. (From Dorland, 27th ed)

Gastric analysis for determination of free acid or total acid.

A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.

Cytosine nucleotides which contain deoxyribose as the sugar moiety.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.

A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)

Vomiting of blood that is either fresh bright red, or older "coffee-ground" in character. It generally indicates bleeding of the UPPER GASTROINTESTINAL TRACT.

Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.

A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.

An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.

An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.

Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)

Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.

Therapy with two or more separate preparations given for a combined effect.

Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.

The black, tarry, foul-smelling FECES that contain degraded blood.

Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.

Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.

The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.

Adenine nucleotides which contain deoxyribose as the sugar moiety.

Strips of elastic material used to apply pressure to body parts to control EDEMA and aid circulation.

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)

A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.

7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.

Substances that reduce the growth or reproduction of BACTERIA.

A purine base and a fundamental unit of ADENINE NUCLEOTIDES.

Research carried out by nurses that uses interviews, data collection, observation, surveys, etc., to evaluate nursing, health, clinical, and nursing education programs and curricula, and which also demonstrates the value of such evaluation.

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Tumors or cancer of the STOMACH.

A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.

The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.

Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).

Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.

Death and putrefaction of tissue usually due to a loss of blood supply.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.

The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Anatomical and functional disorders affecting the foot.

A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).

The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.

Skin diseases caused by bacteria.

The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)

Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)

A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.

Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.

A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.

The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

A republic in western Africa, south of NIGER and between TOGO and NIGERIA. Its capital is Porto-Novo. It was formerly called Dahomey. In the 17th century it was a kingdom in the southern area of Africa. Coastal footholds were established by the French who deposed the ruler by 1892. It was made a French colony in 1894 and gained independence in 1960. Benin comes from the name of the indigenous inhabitants, the Bini, now more closely linked with southern Nigeria (Benin City, a town there). Bini may be related to the Arabic bani, sons. (From Webster's New Geographical Dictionary, 1988, p136, 310 & Room, Brewer's Dictionary of Names, 1992, p60)

An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3d ed)

A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Substances that reduce or suppress INFLAMMATION.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)

An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.

The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.

A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.

A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.

A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.

Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.

The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.

Pathological development in the ILEUM including the ILEOCECAL VALVE.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)

Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.

Research carried out by nurses in the clinical setting and designed to provide information that will help improve patient care. Other professional staff may also participate in the research.

Invasion of the site of trauma by pathogenic microorganisms.

A genus of bacteria causing GRANULOMA INGUINALE and other granulomatous lesions.

Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.

Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.

A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.

Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

The structure of one molecule that imitates or simulates the structure of a different molecule.

Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.

The segment of GASTROINTESTINAL TRACT that includes the ESOPHAGUS; the STOMACH; and the DUODENUM.

The rate dynamics in chemical or physical systems.

Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.

The relationship between the dose of an administered drug and the response of the organism to the drug.

A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.

Pathological processes of the VULVA.

The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.

The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.

The inferior part of the lower extremity between the KNEE and the ANKLE.

A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (1/1640)

OBJECTIVE: To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease. DESIGN: Randomised, multicentre, double blind, controlled study. Patients with heartburn and normal endoscopy results or mild erosive changes received omeprazole 10 mg or 20 mg daily or ranitidine 150 mg twice daily for 2 weeks. Patients remaining symptomatic had omeprazole 10 mg or ranitidine dose doubled for another 2 weeks while omeprazole 20 mg was continued for 2 weeks. Patients who were symptomatic or mildly symptomatic were followed up for 12 months. Recurrences of moderate or severe heartburn during follow up were treated with the dose which was successful for initial symptom control. SETTING: Hospitals and primary care practices between 1994 and 1996. SUBJECTS: 677 patients with gastro-oesophageal reflux disease. MAIN OUTCOME MEASURES: Total time off active treatment, time to failure of intermittent treatment, and outcomes ranked from best to worst. RESULTS: 704 patients were randomised, 677 were eligible for analyses; 318 reached the end of the study with intermittent treatment without recourse to maintenance antisecretory drugs. The median number of days off active treatment during follow up was 142 for the entire study (281 for the 526 patients who reached a treatment related end point). Thus, about half the patients did not require treatment for at least 6 months, and this was similar in all three treatment groups. According to outcome, 378 (72%) patients were in the best outcome ranks (no relapse or one (or more) relapse but in remission until 12 months); 630 (93%) had three or fewer relapses in the intermittent treatment phase. Omeprazole 20 mg provided faster relief of heartburn. The results were similar in patients with erosive and non-erosive disease. CONCLUSIONS: Intermittent treatment is effective in managing symptoms of heartburn in half of patients with uncomplicated gastro-oesophageal reflux disease. It is simple and applicable in general practice, where most patients are seen. (+info)

Can restrictions on reimbursement for anti-ulcer drugs decrease Medicaid pharmacy costs without increasing hospitalizations? (2/1640)

OBJECTIVE: To examine the impact of a policy restricting reimbursement for Medicaid anti-ulcer drugs on anti-ulcer drug use and peptic-related hospitalizations. DATA SOURCES/STUDY SETTING: In addition to U.S. Census Bureau data, all of the following from Florida: Medicaid anti-ulcer drug claims data, 1989-1993; Medicaid eligibility data, 1989-1993; and acute care nonfederal hospital discharge abstract data (Medicaid and non-Medicaid), 1989-1993. STUDY DESIGN: In this observational study, a Poisson multiple regression model was used to compare changes, after policy implementation, in Medicaid reimbursement for prescription anti-ulcer drugs as well as hospitalization rates between pre- and post-implementation periods in Medicaid versus non-Medicaid patients hospitalized with peptic ulcer disease. PRINCIPAL FINDINGS: Following policy implementation, the rate of Medicaid reimbursement for anti-ulcer drugs decreased 33 percent (p < .001). No associated increase occurred in the rate of Medicaid peptic-related hospitalizations. CONCLUSIONS: Florida's policy restricting Medicaid reimbursement for anti-ulcer drugs was associated with a substantial reduction in outpatient anti-ulcer drug utilization without any significant increase in the rate of hospitalization for peptic-related conditions. (+info)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (3/1640)

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa. (+info)

Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. (4/1640)

Anti-ulcer effects of cetraxate, a new compound possessing anti-plasmin, anti-casein and anti-trypsin actions were investigated by using experimental gastric ulcer models in rats. Cetraxate, 300 mg/kg p.o. showed significant inhibitory effects of 65.3%, 70.0%, 30.2%, and 67.1% against aucte types of ulcers producing by aspirin, phenylbutazone, indomethacin, and pyloric ligature (Shay's ulcer), respectively. These effects were greater than those obtained by gefarnate and aluminum sucrose sulfate may be mainly attributed to the protecting action of this drug on gastric mucosa. Ctraxate further revealed remarkable inhibitory effects on chronic types of ulcers produced by acetic acid, clamping, and clamping-cortisone. In acetic acid ulcer in particular, cetraxate was found to have a dose-dependent inhibitory effect at doses over 50 mg/kg. Of test drugs including L-glutamine and methylmethionine sulfonium chloride, cetraxate showed the most remarkable inhibitory effect on beta-glucuronidase activity in ulcer tissue of these three types of ulcers. These findings suggest that cetraxate may prevent the connective tissue in the ulcer location from decomposition due to lysosomal enzymes such as beta-glucuronidase, thereby accelerating the recovery from ulcer. (+info)

Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. (5/1640)

1. This study used intravital microscopy to investigate the receptors stimulated by amylin which shares around 50% sequence homology with the vasodilator calcitonin gene-related peptide (CGRP) in the hamster cheek pouch microvasculature in vivo. 2. Receptor agonists dilated arterioles (diameters 20-40 microm). The -log of the concentrations (+/- s.e.mean; n = 8) causing 50% increase in arteriole diameter were: human betaCGRP (10.8 +/- 0.3), human alphaCGRP (10.8 +/- 0.4), rat alphaCGRP (10.4 +/- 0.3). Rat amylin and the CGRP2 receptor selective agonist [Cys(ACM2,7]-human alphaCGRP were 100 fold less potent (estimates were 8.5 +/- 0.4 and 8.2 +/- 0.3 respectively). 3. The GCRP1 receptor antagonist, CGRP8-37 (300 nmol kg(-1); i.v.) reversibly inhibited the increase in diameter evoked by human alphaCGRP (0.3 nM) from 178 +/- 22% to 59 +/- 12% (n = 8; P < 0.05) and by rat amylin (100 nM) from 138 +/- 23% to 68 +/- 24% (n = 6; P < 0.05). CGRP8-37 did not inhibit vasodilation evoked by substance P (10 nM; n = 4: P > 0.05). 4. The amylin receptor antagonist, amylin8-37 (300 nmol kg(-1); i.v.) did not significantly inhibit the increase in diameter evoked by human alphaCGRP (0.3 nM) which was 112 +/- 26% in the absence, and 90 +/- 29% in the presence of antagonist (n = 4; P < 0.05); nor that evoked by rat amylin (100 nM) which was 146 +/- 23% in the absence and 144 +/- 32% in the presence of antagonist (n = 4; P > 0.05). 5. The agonist profile for vasodilatation and the inhibition of this dilatation by CGRP8-37, although not the amylin8-37 indicates that amylin causes vasodilatation through interaction with CGRP1 receptors in the hamster cheek pouch. (+info)

Maleic acid and succinic acid in fermented alcoholic beverages are the stimulants of gastric acid secretion. (6/1640)

Alcoholic beverages produced by fermentation (e.g., beer and wine) are powerful stimulants of gastric acid output and gastrin release in humans. The aim of this study was to separate and specify the gastric acid stimulatory ingredients in alcoholic beverages produced by fermentation. Yeast-fermented glucose was used as a simple model of fermented alcoholic beverages; it was stepwise separated by different methods of liquid chromatography, and each separated solution was tested in human volunteers for its stimulatory action on gastric acid output and gastrin release. Five substances were detected by high-performance liquid chromatography and were analyzed by mass spectrometry and 1H-13C nuclear magnetic resonance spectroscopy. At the end of the separation process of the five identified substances, only the two dicarboxylic acids, maleic acid and succinic acid, had a significant (P < 0.05) stimulatory action on gastric acid output (76% and 70% of fermented glucose, respectively), but not on gastrin release. When given together, they increased gastric acid output by 100% of fermented glucose and by 95% of maximal acid output. We therefore conclude that maleic acid and succinic acid are the powerful stimulants of gastric acid output in fermented glucose and alcoholic beverages produced by fermentation, and that gastrin is not their mediator of action. (+info)

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole. (7/1640)

BACKGROUND: Omeprazole has a greater intragastric pH elevating effect in Helicobacter pylori positive than negative subjects. Ammonia production by H pylori has been suggested as a probable mechanism. AIMS: To assess the effect of H pylori status on gastric acid secretion during omeprazole treatment, and to examine the possible role of ammonia neutralisation of intragastric acid in increased omeprazole efficacy in infected subjects. METHODS: Twenty H pylori positive and 12 H pylori negative healthy volunteers were examined before and six to eight weeks after commencing omeprazole 40 mg/day. On both occasions plasma gastrin and acid output were measured basally and in response to increasing doses of gastrin 17 (G-17). Gastric juice ammonium concentrations were also measured. RESULTS: Prior to omeprazole, measurements were similar in the H pylori positive and negative subjects. During omeprazole, median basal intragastric pH was higher in the H pylori positive (7.95) versus negative (3.75) subjects (p<0.002). During omeprazole basal, submaximal (180 pmol/kg/h G-17), and maximal acid outputs (800 pmol/kg/h G-17) were lower in H pylori positive subjects (0.0, 3.6, 6.0 mmol/h respectively) versus negative subjects (0.3, 14.2, 18.6 mmol/h) (p<0.03 for each). This effect was not explained by neutralisation by ammonia. CONCLUSION: The presence of H pylori infection leads to a more profound suppression of acid secretion during omeprazole treatment. The effect cannot be explained by neutralisation of intragastric acid by bacterial ammonia production and its precise mechanism has to be explained. (+info)

Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels. (8/1640)

The anti-ulcer effects of nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester] were examined on water-immersion plus restraint stress-induced and aspirin-induced gastric ulcers in rats, compared with those of cimetidine. Nicorandil (3 and 10 mg/kg) given orally to rats dose-dependently inhibited the development of acid-related damage (water-immersion- and aspirin-induced gastric lesions) in the models. Cimetidine (50 mg/kg, p.o.) also had anti-ulcer effects in the same models. However, in the presence of glibenclamide (20 mg/kg, i.v.), an antagonist of K(ATP) channels, nicorandil did not inhibit the formation of gastric lesions. Nicorandil (10 mg/kg) given intraduodenally (i.d.), like cimetidine (50 mg/kg), significantly reduced the volume of the gastric content, total acidity and total acid output in the pylorus ligation model. Glibenclamide reversed the changes caused by i.d. nicorandil. I.v. infusion of nicorandil (20 microg/kg per min) significantly increased gastric mucosal blood flow, without affecting blood pressure and heart rate, but the increase in the blood flow was not observed after i.v. treatment with glibenclamide (20 mg/kg). These results indicate that nicorandil administered orally to rats produces the anti-ulcer effect by reducing the aggressive factors and by enhancing the defensive process in the mucosa through its K(ATP)-channel-opening property. (+info)

Kaminski, James J.; Doweyko, Arthur M. (1997). "Antiulcer Agents. 6. Analysis of the in Vitro Biochemical and in Vivo Gastric ... and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are ... Nelson, Wendel L (2008). "Antihistamines and Related Antiallergic and Antiulcer Agents". In Lemke, Thomas L.; Williams, David A ... These new agents can in a reversible and competitive fashion inhibit the final step in the gastric acid secretion with respect ...

https://en.wikipedia.org/wiki/Discovery_and_development_of_proton_pump_inhibitors

... (BEX) is an anti-ulcer agent used in the treatment of acid-related disorders. It is unique in its inability to form ... Benexate is approved from treatment of gastric ulcer in Japan. The mechanism of action of benexate involves promotion of ... effect of inclusion compound formation on the antiulcer activity of benexate, the effective ingredient of benexate CD". Folia ... "Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers". Experimental and ...

https://en.wikipedia.org/wiki/Benexate

Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ... Refractory corneal ulcers are superficial ulcers that heal poorly and tend to recur. They are also known as indolent ulcers or ... Superficial ulcers involve a loss of part of the epithelium. Deep ulcers extend into or through the stroma and can result in ... Melting ulcers are a type of corneal ulcer involving progressive loss of stroma in a dissolving fashion. This is most commonly ...

https://en.wikipedia.org/wiki/Corneal_ulcer

Philip Agee, 72, American CIA agent, complications from perforated ulcer surgery. Raffaello de Banfield, 85, British composer. ... "Anti-pop-art artist, Holocaust survivor Lurie dead". Earth Times. January 8, 2008. Archived from the original on May 20, 2011. ... Yunus Mohamed, 57, South African lawyer and anti-Apartheid activist. Ken Nelson, 96, American record producer and member of the ... Martin, Douglas (January 17, 2008). "Milton Wolff, 92, Dies; Anti-Franco Leader". The New York Times. Retrieved October 4, 2017 ...

https://en.wikipedia.org/wiki/Deaths_in_January_2008

... a novel anti-gastric ulcer agent: tautomeric change of imidazole moiety upon complexation". Chem Pharm Bull. 38 (11): 3140-6. ... which has been clinically used to treat gastric ulcers. Its mechanism of action is believed to oxygen radical scavenging, anti- ... Forty-two patients with stage II-IV pressure ulcers for 4 or more weeks were allocated to 1 of 3 groups in order of recruitment ... Zinc L-carnosine (ZnC), which is clinically used as gastric ulcer treatment in Japan, has been suggested to have the potential ...

https://en.wikipedia.org/wiki/Zinc_L-carnosine

... is a systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting ... was achieved in patients with gastric ulcer and duodenal ulcer respectively. In patients with acute gastritis and acute gastric ... Hyeoyun (1989). "Peptic ulcers for the clinical effectiveness of Troxipide". Latest Med. 32 (2): 125-31. Dewan B, ... In patients with APDs like dyspepsia, gastritis, GERD and/or gastric ulcer, uncontrolled with acid inhibitors viz. proton pump ...

https://en.wikipedia.org/wiki/Troxipide

It has been used as an effective anti-inflammatory agent as well as for treating fever, wounds, ulcers, and diarrhoea. It also ...

https://en.wikipedia.org/wiki/Lysimachia_vulgaris

Several case reports showed that biological agents, such as anti-tumor necrosis factor alpha (anti-TNF) or monoclonal ... Xia, Annie; Dietrich-Ntoukas, Tina; Pleyer, Uwe (2022-01-20). "Effect of Anti-TNF Treatment on Mooren's Ulcer: A Case Series ... Mooren's ulcer is also defined as a special and the most common type of peripheral ulcerative keratitis (PUK). Symptoms of ... Mooren's ulcer is a rare idiopathic ocular disorder that may lead to blindness due to progressive destruction of the peripheral ...

https://en.wikipedia.org/wiki/Mooren's_ulcer

Anti-Infective Effects of Sugar-Vaseline Mixture on Leg Ulcers O'Meara S, Martyn-St James M (May 2013). "Foam dressings for ... It is not certain which dressings and topical agents are most effective for healing venous leg ulcers. Silver-containing ... A venous ulcer is typically shallow with irregular sloping edges whereas an arterial ulcer can be deep and has a 'punched out' ... Cochrane Wounds Group) (November 2012). "Topical agents or dressings for pain in venous leg ulcers". The Cochrane Database of ...

https://en.wikipedia.org/wiki/Venous_ulcer

... an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese ... and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor ... Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. ... Ito M, Yokochi E, Kobayashi C, Suzuki Y (April 1982). "[Studies on defensive factors of experimental ulcers (2). Increasing ...

https://en.wikipedia.org/wiki/Aceglutamide

... an anti-ulcer agent that can cause gynecomastia in men because of this effect). Clarithromycin and other macrolide antibiotics ... Initial treatment is with increased cleansing (at least twice daily) with an anti-acne or oil reducing scrub. If this doesn't ...

https://en.wikipedia.org/wiki/Masculinizing_hormone_therapy

... antifungal agent), meloxicam and fentiazac (anti-inflammatory agents) and nizatidine (anti-ulcer agent). Consequently, ... A couple of the compounds that were analysed for in vivo anti-cancer activity contained thiazole derivatives that had been ... Thiazoles are found in a number of pharmacological compounds such as tiazofurin and dasatinib (antineoplastic agents), ...

https://en.wikipedia.org/wiki/Cook–Heilbron_thiazole_synthesis

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more ... A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal ... Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing ... Cytoprotection is a process by which chemical compounds provide protection to cells against harmful agents. ...

https://en.wikipedia.org/wiki/Cytoprotection

... the use of anti-diabetic agents, the treatment of gout, the treatment of peptic ulcers, anxiolytic drugs, and the therapy of ...

https://en.wikipedia.org/wiki/Arthur_Obel

Their clinical use has been established as anti-glaucoma agents, diuretics, antiepileptics, in the management of mountain ... sickness, gastric and duodenal ulcers, idiopathic intracranial hypertension, neurological disorders, or osteoporosis. Carbonic ...

https://en.wikipedia.org/wiki/Carbonic_anhydrase_inhibitor

Another Anti-TNF agent, etanercept, may be useful in people with mainly skin and mucosal symptoms. Apremilast may also be used ... genital ulcers (including anal ulcers and spots in the genital region and swollen testicles or epididymitis in men) pathergy ... The anti-HSP60 and anti-HSP65 antibodies that target HSPs produced by Streptococci (including S. sanguinis and S. pyogenes) and ... They are a form of aphthous ulcers or non-scarring oral lesions. The oral lesions are similar to those found in inflammatory ...

https://en.wikipedia.org/wiki/Behçet's_disease

The company was investigating anti-spasmodic agents, similar to tropine, for treating gastrointestinal ailments when the ... It was then investigated for possible use in ulcer treatment, but was found unsuitable. At this time the United States military ... Agent 15'. Agent 15 is an alleged Iraqi incapacitating agent that is likely to be chemically identical to BZ or closely related ... The Psycho Agents by Reid Kirby Department of Defense-Agent BZ use in Hawaii April through June 1966. (CS1 maint: others, CS1 ...

https://en.wikipedia.org/wiki/3-Quinuclidinyl_benzilate

These infectious agents produce proteases and collagenases which break down the corneal stroma. Complete loss of the stroma can ... Contains macroglobulins with anti-collagenase effects. A combination of the above may be necessary early in the disease course ... Refractory corneal ulcers are superficial ulcers that heal poorly and tend to recur. They are also known as indolent ulcers or ... Superficial ulcers involve a loss of part of the epithelium. Deep ulcers extend into or through the stroma and can result in ...

https://en.wikipedia.org/wiki/Corneal_ulcers_in_animals

ISBN 978-0-85404-596-9. v t e (Drugs, Anti-infective agents, All stub articles, Pharmacology stubs). ... Examples of metallopharmaceuticals include: bismuth subsalicylate - a mild anti-diarrheal also used in treating peptic ulcers ... 2005). Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley and Sons. ISBN 978 ... Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents. The efficiency of metallopharmaceuticals ...

https://en.wikipedia.org/wiki/Metallopharmaceutical

Anti-aggregation agents such as apomorphine, or carbenoxolone. The latter has commonly been used as a treatment for peptic ... ulcers, but also displays neuroprotective properties, shown to improve cognitive functions such as verbal fluency and memory ... This is a common mechanism of action of anti-aggregation agents at large. Studies comparing synthetic to recombinant Aβ42 in ... 2017). "Lessons from Anti-Amyloid-β Immunotherapies in Alzheimer Disease: Aiming at a Moving Target". review. Neuro- ...

https://en.wikipedia.org/wiki/Amyloid_beta

"Anti-bridge campaigner dies". The Advertiser. AAP. December 2, 2007. Retrieved June 23, 2018. "Professor David Maybury-Lewis". ... Allan Berube, 61, American gay historian and writer, complications from stomach ulcers. José Luis Calva, 38, Mexican writer, ... Freddie Fields, 84, American Hollywood agent, producer and studio executive, lung cancer. Pat Hannigan, 71, Canadian ice hockey ... Jim Nevill, 80, British police officer, former head of Scotland Yard anti-terrorist squad. Alfons Maria Stickler, 97, Austrian ...

https://en.wikipedia.org/wiki/Deaths_in_December_2007

... and also stomach or duodenal ulcers. It also contains simethicone, an anti-foaming agent which helps eliminate bloating from ... Maalox Extra Strength + Anti-Gas tablets contain 1000 mg of calcium carbonate and 60 mg of simethicone. Maalox is used to treat ... Some may find certain Maalox medications, such as Maalox Multi-Action, to be a successful anti-diarrhea treatment due to the ... David Ferguson (2011-09-28). "'Maalox'-and-water solution used as anti-tear gas remedy by protesters". Raw Story. Archived from ...

https://en.wikipedia.org/wiki/Maalox

... and extracts have been examined as a possible anti-cancer agent. Ayurveda uses insects such as Termite for conditions such as ... and anti-inflammatory properties. Royal jelly is used to treat anaemia, gastrointestinal ulcers, arteriosclerosis, hypo- and ... Tick anti-hemostatics: targets for future vaccines and therapeutics. Trends Parasitol. 23, 397e407. Pierce, BA (2006). Genetics ... ISBN 978-0-300-11741-7. Munro, John H. (2007). Netherton, Robin; Owen-Crocker, Gale R. (eds.). The Anti-Red Shift - To the Dark ...

https://en.wikipedia.org/wiki/Human_interactions_with_insects

This discovery has led to the development of novel anti-tropomyosin compounds as potential anti-cancer agents. Tropomyosins ... have been implicated in the autoimmune disease ulcerative colitis, a disease of the colon that is characterised by ulcers or ... Smooth muscle may contract spontaneously or rhythmically and be induced by a number of physiochemical agents (hormones, drugs, ...

https://en.wikipedia.org/wiki/Tropomyosin

Jones P, Lamdin R, Dalziel SR (August 2020). "Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for ... Lanas A, Chan FK (August 2017). "Peptic ulcer disease". The Lancet. 390 (10094): 613-624. doi:10.1016/S0140-6736(16)32404-7. ... These agents may also cause kidney impairment, especially in combination with other nephrotoxic agents. Kidney failure is ... Most nonsteroidal anti-inflammatory drugs are weak acids, with a pKa of 3-5. They are absorbed well from the stomach and ...

https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug

A root extract is taken thrice daily for the treatment of gastric ulcers, and taken twice daily for the treatment of jaundice ... Its use as an antiinflammatory and analgesic agent has been supported by experiments in mice. The rhizome, cooked or raw, has ... Das BN, Biswas BK (2012). "Anti-inflammatory activity of the rhizome extract of Alpinia nigra". International Research Journal ...

https://en.wikipedia.org/wiki/Alpinia_nigra

Hollenbeck's agent said he had been suffering from a bleeding ulcer. Hollenbeck's body was discovered at about 11 a.m. after ... Regarding Condon, Hollenbeck critiqued anti-communists for going about their business the wrong way: Communists want nothing ... It ended up becoming a target for anti-communists, and subsequently it went out of business in 1948. Because of this ...

https://en.wikipedia.org/wiki/Don_Hollenbeck

These effects are dose-dependent, and in many cases severe enough to pose the risk of ulcer perforation, upper gastrointestinal ... Furthermore, to date all migraine-provoking agents have had vasodilating properties. In patients where the pain has been ... Recommended initial treatment for those with mild to moderate symptoms are simple analgesics such as non-steroidal anti- ... Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek ...

https://en.wikipedia.org/wiki/Migraine_treatment

... povidone-iodine paste is an effective agent for the treatment of diabetic ulcers with MRSA infection. Maintaining the necessary ... Moreover, the efficacy of vancomycin against MRSA is inferior to that of anti-staphylococcal beta-lactam antibiotics against ... diabetic ulcer, pressure ulcer, arterial insufficiency ulcer, venous ulcer). No conclusive evidence has been found about the ... The use of concurrent treatment with vancomycin or other beta-lactam agents may have a synergistic effect.: 637 Both CA-MRSA ...

https://en.wikipedia.org/wiki/Methicillin-resistant_Staphylococcus_aureus

Seasonal allergies can also be treated by drinking cups of tea containing rosemarynic acid: an anti-inflammatory agent found in ... and stomach ulcers. ...

https://en.wikipedia.org/wiki/Arabic_tea

Sippy prescribed patients with ulcers milk and alkali, on the theory that ulcers were caused by excessive gastric acid. Further ... Calcimimetic agents may be necessary, e.g. Cinacalcet.[citation needed] In mild cases of milk-alkali syndrome, full recovery is ... Angiotensin-converting enzyme (ACE) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) are also drugs associated ... Previously, milk-alkali syndrome was predominantly seen amongst males with ulcers. As new treatments for peptic ulcers arose, ...

https://en.wikipedia.org/wiki/Milk-alkali_syndrome

The preventive effect of indeloxazine hydrochloride to the sexual dysfunction caused by anti-androgenergic agent (allylestrenol ... Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek ... Yamanaka H, Kosaku N, Makino T, Shida K (September 1983). "[Fundamental and clinical study of the anti-prostatic effect of ... Iguchi H, Ikeuchi T, Kai Y, Yoshida H (March 1994). "[Influence of anti-androgen therapy for prostatic hypertrophy on lipid ...

https://en.wikipedia.org/wiki/Allylestrenol

"Anti-vaxxers stopped the last Lyme disease vaccine. The FDA has just fast-tracked a new one". Newsweek. 25 July 2017. Archived ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... Cellulitis most commonly develops around a wound or ulcer, is rarely circular, and is more likely to become swollen and tender ... Masuzawa T (December 2004). "Terrestrial distribution of the Lyme borreliosis agent Borrelia burgdorferi sensu lato in East ...

https://en.wikipedia.org/wiki/Lyme_disease

Although it is common practice nowadays to view missionaries as agents of western imperialism, Bliss comes across well in his ... In 1897 they killed two German missionaries in the province.: 21 Anti-foreign sentiments increased and led to killing of ... He treated conditions such as leg ulcers, scabies, erysipelas, consumption and malaria,: 60 but was unable to perform major ... Lutz, J. (1976). "Chinese nationalism and the anti-christian campaigns of the 1920s". Modern Asian Studies, 10(3), 395-416. " ...

https://en.wikipedia.org/wiki/Edward_Bliss

Hess continued to be an unapologetic Nazi and anti-Semite; this was usually ignored by those championing his release, who ... ISBN 0-261-63246-9. Milmo, Cahal (10 September 2013). "Adolf Hitler's Nazi deputy Rudolf Hess 'murdered by British agents' to ... when he was a patient at the British Military Hospital in West Berlin for a perforated ulcer. By this time, Wolf Rüdiger Hess ... and offering a negotiated peace or even an anti-Bolshevik partnership. Soviet leader Joseph Stalin believed that Hess's flight ...

https://en.wikipedia.org/wiki/Rudolf_Hess

... famciclovir is effective at treating this infection in cats without the side effects reported with other anti-viral agents. ... Conjunctivitis and corneal ulcers are treated with topical antibiotics for secondary bacterial infection. Lysine is commonly ... FHV-1 also has a predilection for corneal epithelium, resulting in corneal ulcers, often pinpoint or dendritic in shape. Other ...

https://en.wikipedia.org/wiki/Feline_viral_rhinotracheitis

It is the causative agent of African swine fever (ASF). The virus causes a hemorrhagic fever with high mortality rates in ... skin ulcers, and swollen joints. The clinical symptoms of ASFV infection are very similar to classical swine fever, and the two ... claimed that anti-Castro saboteurs, with at least the tacit backing of U.S. Central Intelligence Agency officials, allegedly ...

https://en.wikipedia.org/wiki/African_swine_fever_virus

... anti-ulcer effects, and antioxidant properties. The nipa palm of Asia (sugar, vinegar, alcohol, and fodder) and honey ... macropomum enter the Amazonian floodplains during annual floods egesting viable seeds thus acting as an important agent of ...

https://en.wikipedia.org/wiki/Wetland

... anti-imperialist, anti-colonialist and pro-democratic ideas. - Fidel Castro on the Bogotazo, 2009 In June 1947, Castro learned ... Requiring funding, Castro toured the U.S. in search of wealthy sympathizers, there being monitored by Batista's agents, who ... saying that his doctor had Castro reduce his cigar usage starting in 1980 and quit entirely in 1983 after a cancerous ulcer was ... Anti-capitalists, Anti-imperialism, Communist rulers, Collaborators with the Soviet Union, Cuban guerrillas, 20th-century Cuban ...

https://en.wikipedia.org/wiki/Fidel_Castro

Bellemore SM, Nikoopour E, Au BC, Krougly O, Lee-Chan E, Haeryfar SM, Singh B (2014). "Anti-atherogenic peptide Ep1.B derived ... Typically, the disease presents with skin lesions (e.g. nodules, tumors, papules, bruise-like patches, and/or ulcers) that most ... update on therapy especially novel agents". Annals of Hematology. 97 (4): 563-572. doi:10.1007/s00277-018-3259-z. PMID 29455234 ... "Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12". ...

https://en.wikipedia.org/wiki/Dendritic_cell

Some work was conducted during the war with the use of liquid forms of the pathogen agents but the results were unsatisfactory ... One victim, Jiand Chun Geng, suffered flesh-eating ulcers. Others suffered untreated infections that led to death. There were ... Coble, Parks M. (June 2007). "China's "New Remembering" of the Anti-Japanese War of Resistance, 1937-1945". The China Quarterly ... This unit was tasked with performing experiments into chemical agents that had the potential to be used and developed into ...

https://en.wikipedia.org/wiki/Kaimingjie_germ_weapon_attack

... oral anti-diabetics, colestyramine, dextromethorphan, mifepristone, corticosteroids, anti-platelet agents and selective ... have an active stomach or intestinal ulcer; have had an acute asthmatic attack, hives, rhinitis (inflammation of the inner ... Tenoxicam, sold under the brand name Mobiflex among others, is a nonsteroidal anti-inflammatory drug (NSAID). It is used to ... "Assessment report for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and cardiovascular risk" (PDF). European Medicines Agency ...

https://en.wikipedia.org/wiki/Tenoxicam

... anthelmintic agent, for the treatment of cough, respiratory diseases, skin diseases, wounds, ulcer, gout, and rheumatism. ... Yelchuri, Bala Murali Krishna (22 January 2012). "India-Tanzania-Thailand Scientists to Study 'Bitter Gourd' for anti-diabetes ...

https://en.wikipedia.org/wiki/Momordica_charantia

The use for sucralfate in peptic ulcer disease has diminished recently, but it is still the preferred agent for stress ulcer ... Sucralfate is used for the treatment of active duodenal ulcers not related to the use of nonsteroidal anti-inflammatory drugs ( ... Active duodenal ulcer not related to NSAID use Maintenance therapy for resolved duodenal ulcers Gastric ulcer not related to ... Stress ulcer prophylaxis-The use of sucralfate rather than H2 antagonists for stress ulcer prophylaxis, and measures to prevent ...

https://en.wikipedia.org/wiki/Sucralfate

Possible causes of such ulcers are: Restricted blood supply to the anastomosis (compared to the blood supply available to the ... esomeprazole A cytoprotectant and acid buffering agent, e.g. sucralfate Temporary restriction of the consumption of solid foods ... original stomach) Anastomosis tension Gastric acid The bacteria Helicobacter pylori Smoking Use of non-steroidal anti- ... Today thousands of "loops" are used for surgical procedures to treat gastric problems such as ulcers, stomach cancer, and ...

https://en.wikipedia.org/wiki/Gastric_bypass_surgery

These three anti-leprosy drugs are still used in the standard MDT regimens. None of them is used alone because of the risk of ... He tried the oil as an oral and topical agent in two cases of leprosy and reported significant improvements in an 1854 paper. ... Given by enema may cause peri-anal ulcers and fissures. Given by injection the drug caused fever and other local reactions. ... These three anti-leprosy drugs are still used in the standard MDT regimens. The word leprosy comes from ancient Greek Λέπρα [ ...

https://en.wikipedia.org/wiki/History_of_leprosy

It is deemed to be a first-line agent for short-term treatment of insomnia in people 55 years old or older. Positions on the ... A 2013 review by the National Cancer Institute found insufficient evidence for melatonin having anti-cancer effects. A 2022 ... mouth ulcers, dry mouth, hyperbilirubinaemia, dermatitis, night sweats, pruritus, rash, dry skin, pain in the extremities, ...

https://en.wikipedia.org/wiki/Melatonin_as_a_medication_and_supplement

A 2015 NICE review found the main side effect to be bleeding that occurred in about 38% of cases, and radiation-induced ulcer ... These medications were the first agents of what is known as radioimmunotherapy, and they were approved for the treatment of ... In 2002, the United States Food and Drug Administration (FDA) approved ibritumomab tiuxetan (Zevalin), which is an anti-CD20 ... of the radioactive agents being infused. Methods, techniques and devices are available to lower the occurrence of this type of ...

https://en.wikipedia.org/wiki/Radiation_therapy

see autoantibody). These anti-host DNA antibodies are able to stimulate pDCs which proceed to secrete IFN, furthering the ... Typically, the disease presents with skin lesions (e.g. nodules, tumors, papules, bruise-like patches, and/or ulcers) that most ... update on therapy especially novel agents". Annals of Hematology. 97 (4): 563-572. doi:10.1007/s00277-018-3259-z. PMID 29455234 ... which are critical anti-viral compounds mediating a wide range of effects and induce maturation of the pDC. For example, the ...

https://en.wikipedia.org/wiki/Plasmacytoid_dendritic_cell

Various steroid sparing agents e.g. sodium cromoglycate (a stabilizer of mast cell membranes), ketotifen (an antihistamine), ... "Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis". The New England Journal of Medicine. 383 (17): 1624-1634. ... acute appendicitis and giant refractory duodenal ulcer. Peripheral blood eosinophilia and elevated serum IgE are usual but not ...

https://en.wikipedia.org/wiki/Eosinophilic_gastroenteritis

Anti-inflammatory drugs and immunomodulatory agents such as dapsone, hydroxychloroquine, cyclosporine, interferon alfa, ... ulcers, necrosis, scarring) and concurrent or subsequent systemic symptoms (high-grade fever and/or malaise; less commonly, ... These treatments may include systemic corticosteroids, second generation H1 anti-histamines, and anti-pyretics similar to those ... Episodes of the disorder are sometimes triggered by: drugs (e.g. antimicrobial agents, biologics, antihypertensive agents, ...

https://en.wikipedia.org/wiki/Mosquito_bite_allergy

Her longtime agent and literary executor Marie Rodell spent nearly two years organizing and cataloging Carson's papers and ... Others, such as Yaakov Garb, suggest that in addition to not being a women's rights activist, Carson also had no anti- ... However, in January, a duodenal ulcer followed by several infections kept her bedridden for weeks, greatly delaying the ... That year, she took on a literary agent, Marie Rodell; they formed a close professional relationship that would last the rest ...

https://en.wikipedia.org/wiki/Rachel_Carson

Mallo, N.; Defelipe, A. P.; Folgueira, I.; Sueiro, R. A.; Lamas, J.; Leiro, J. M. (2017). "Combined antiparasitic and anti- ... The species was also identified as the causative agent of outbreaks of scuticociliatosis that occurred between summer 1999 and ... Infected fish show haemorrhagic ulcers on the skin (particularly around the operculum), abundant ascitic fluid in the abdominal ... Mallo, Natalia; Lamas, Jesús; Leiro, José M. (2014). "Alternative oxidase inhibitors as antiparasitic agents against ...

https://en.wikipedia.org/wiki/Philasterides_dicentrarchi

Loeb cited ulcers for his medical exemption from service during World War II, allegedly drinking large quantities of alcohol ... In New Hampshire, his major legacy is an anti-tax pledge that has been taken not only by all Republicans seeking gubernatorial ... Loeb refused to permit Gallowhur's agents from serving her, and he was jailed briefly for interfering. Gallowhur sued Loeb for ... Also in 1949, Loeb became the third president of American China Policy Association (ACPA), an anti-communist organization that ...

https://en.wikipedia.org/wiki/William_Loeb_III

... was initially developed as an antifungal agent. However, this use was abandoned when it was discovered to have potent ... The most commonly reported side effects of sirolimus treatment of LAM were mouth and lip ulcers, diarrhea, abdominal pain, ... Liu Y, Yang F, Qu L (2019). "Rapamycin: A Bacteria-Derived Immunosuppressant That Has Anti-atherosclerotic Effects and Its ... Rapamycin is used in biology research as an agent for chemically induced dimerization. In this application, rapamycin is added ...

https://en.wikipedia.org/wiki/Sirolimus

Although anti-trafficking campaigns over the past few years have led to improvements in some forms of trafficking, data ... Often, young women who are attempting to find legitimate work are tricked by agents with promises of a job. Once they have ... bleeding ulcers, and abscesses on legs. There is also the beating these women endure, which result in fractured bones, burns, ... The anti-trafficking campaigns aim at raising awareness about trafficking in women by addressing both the general population ...

https://en.wikipedia.org/wiki/Sex_trafficking_in_Europe

p. 1. "Anti-War March Draws 25,000 in Washington". Ogden Standard-Examiner. Ogden, Utah. November 28, 1965. p. 1. "Estimate ... Six Unknown Named Agents. The Court would rule that, although there was no specific federal law that permitted Bivens to file ... died of a perforated ulcer following a Carnegie Hall concert with Jimmy Dean's band. The musical Man of La Mancha opened off- ... The Sprint (Solid propellant rocket interceptor), a short-range anti-ballistic missile intended to intercept an incoming enemy ...

https://en.wikipedia.org/wiki/November_1965

At the end of the third series, Tom becomes the land agent for the estate at Violet's suggestion, owing to having grown up on a ... Unlike many Russian aristocrats after the Revolution, Prince Kuragin does not appear to be an anti-Semite; when he meets ... and the Earl of Grantham collapses from a perforated ulcer, ending the gathering while he is rushed to hospital. Chamberlain ... Gordon decides to leave, rather than commit to his claim, after learning the earl's agents will be investigating Peter Gordon's ...

https://en.wikipedia.org/wiki/List_of_Downton_Abbey_characters

Antiseptic A product that reduces the presence of infective agents. ARB Angiotensisn Receptor Blocker. An agent which ... Ulcer A break in the skin; a deep sore. People with diabetes may get ulcers from minor scrapes on the feet or legs, from cuts ... Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so ... Ulcers can become infected. Ultralente insulin A type of insulin that is long acting. Medical ultrasound Unit of insulin The ...

https://en.wikipedia.org/wiki/Glossary_of_diabetes

The first is in an anti-phagocytic polysaccharide capsule that protects the bacteria. By encapsulating the bacteria, ... Vibrio vulnificus often causes large, disfiguring ulcers that require extensive debridement or even amputation.[citation needed ... the causative agent of cholera. At least one strain of V. vulnificus is bioluminescent. Infection with V. vulnificus leads to ...

https://en.wikipedia.org/wiki/Vibrio_vulnificus

Prevention of gastric ulcers caused by nonsteroidal anti-inflammatory drugs : reports on individual drugs ... Browsing by Subject "Anti-Ulcer Agents". 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X. Y. Z. * 0 ...

https://extranet.who.int/iris/restricted/browse?authority=Anti-Ulcer+Agents&type=mesh

Desmodium gangeticum: a potent anti-ulcer agent.. Authors: Dharmani, Poonam. Mishra, Pushpesh Kumar. Maurya, Rakesh. Chauhan, ... Dharmani P, Mishra PK, Maurya R, Chauhan VS, Palit G. Desmodium gangeticum: a potent anti-ulcer agent. Indian Journal of ... Anti-ulcer effect of DG may be due to its cytoprotective effect along with antisecretory activity and could act as a potent ... induced gastric ulcer models in Sprague Dawley rats, and histamine (HST, 0.25 mg/kg) induced duodenal ulcer in guinea pigs. We ...

https://imsear.searo.who.int/handle/123456789/58311

Treatment and prophylaxis of peptic ulcer and gastric hypersecretory conditions such as Zollinger-Ellison syndrome. Histamine H ... antiulcer agents is a topic covered in the Daviss Drug Guide. To view the entire topic, please log in or purchase a ... "Antiulcer Agents." Daviss Drug Guide, 18th ed., F.A. Davis Company, 2023. Nursing Central Redesign, nursing.unboundmedicine. ... com/nursingcentral/view/Davis-Drug-Guide/50930/7/antiulcer_agents. Vallerand AHA, Sanoski CAC, Quiring CC. Antiulcer agents. ...

https://nursing.unboundmedicine.com/nursingcentral/view/Davis-Drug-Guide/50930/7/antiulcer_agents?refer=true

Manuka honey appears to be an effective antibacterial wound healing agent against MRSA-colonized leg ulcers. ... Pharmacological Actions : Anti-Bacterial Agents : CK(2894) : AC(1251). Additional Keywords : Antibiotic Resistance : CK(70) : ... Manuka honey appears to be an effective antibacterial wound healing agent against MRSA-colonized leg ulcers. - GreenMedInfo ... in leg ulcers, a means of reducing the bacterial bioburden of such ulcers, other than by the use of either topical or systemic ...

https://greenmedinfo.com/article/manuka-honey-appears-be-effective-antibacterial-wound-healing-agent-against-mr

Anti-Ulcer Agents / therapeutic use* * Esomeprazole / therapeutic use* * Esophageal pH Monitoring * Esophagus / pathology ...

https://pubmed.ncbi.nlm.nih.gov/21366805/?dopt=Abstract

An enantioselective high-performance liquid chromatographic method for the determination of E3810, a new anti-ulcer agent, in ... N2 - An enantioselective high-performance liquid chromatographic method for the determination of E3810, a new anti-ulcer agent ... AB - An enantioselective high-performance liquid chromatographic method for the determination of E3810, a new anti-ulcer agent ... Enantioselective high-performance liquid chromatographic assay for determination of the enantiomers of a new anti-ulcer agent, ...

https://tohoku.pure.elsevier.com/en/publications/enantioselective-high-performance-liquid-chromatographic-assay-fo

agent). The aqueous extract showed significant anti-ulcer activity in ethanol- ... ulcer activity in alcohol-induced ulcer model in experimental animals. Keywords: Antimicrobial and anti-ulcer activity, Ba ... Parameters like ulcer index, percent ulcer protection, total and free acidity were estimated for evaluation of anti-ulcer ... Effects of Lavandula stoechas L. aqueous extract on ulcer index: a; gastric ulcers, b; duodenal ulcers in ethanol-induced ulcer ...

https://www.researchgate.net/publication/344108661_Pharmacological_Evaluation_of_Lavandula_stoechas_L_for_Ethanol-induced_Gastric_Mucosal_Ulce

... so that they are usable for the treatment of gastric and/or duodenal ulcers. ... 239000003699 antiulcer agent Substances 0.000 description 2 * BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound data:image/ ... 208000007107 Stomach Ulcer Diseases 0.000 claims abstract description 5 * 125000000753 cycloalkyl group Chemical group 0.000 ... 208000000718 Duodenal Ulcer Diseases 0.000 claims abstract description 6 * 125000004428 fluoroalkoxy group Chemical group 0.000 ...

https://patents.google.com/patent/EP0254588A1/en

The search for new anti-ulcer agents from plants in Siberia and the Far East]. Eksp Klin Farmakol 1998;61:31-5. View abstract. ... Xing, J. F., Hou, J. Y., Dong, Y. L., and Wang, B. W. Effects on gastric secretion and anti-gastric ulcer action of sea ... In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J Ethnopharmacol 4-26- ... Teng, B. S., Lu, Y. H., Wang, Z. T., Tao, X. Y., and Wei, D. Z. In vitro anti-tumor activity of isorhamnetin isolated from ...

https://www.medicinenet.com/sea_buckthorn/supplements-vitamins.htm

Nonsteroidal Anti-inflammatory Agents (things like ibuprofen)-- tend to cause perforated ulcers. Banamine and aspirin are the ... In the absence of any of these agents, coat the bowel with milk, egg whites, vegetable oil and give a warm water enema. If your ... Cat scratch fever is an infection caused by a bacterial agent transmitted to the human via a cat scratch. * Conjunctivitis in ... Warfarin (Decon; Pindone): grain feeds used as rat/mouse poison, Also used as a prescription anti-coagulant for humans, various ...

http://www.faqs.org/faqs/cats-faq/health-care/

Peripheral Nervous System Agents. Physiological Effects of Drugs. Anti-Inflammatory Agents. Antirheumatic Agents. Anti-Ulcer ... Anti-Inflammatory Agents, Non-Steroidal. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents. ... Ulcer. Gastroenteritis. Gastrointestinal Diseases. Digestive System Diseases. Colonic Diseases. Intestinal Diseases. Pathologic ... Participants must not have had an inadequate response to Interleukin 12 p40 subunit antibody (anti-IL12p40) (e.g. ustekinumab) ...

https://clinicaltrials.gov/ct2/show/NCT04004611

Turning the resultant metal compound/carnosine into useful antioxidants which in turn can be anti-ulcer agents Protecting and ... Ulcers- Cats Claw helps heal ulcers, a very painful medical condition that attacks the lining of the stomach. Ulcers are a ... Act as anti-cancer agent in the body Stabilizes cell membranes and slows down lipid peroxidation to protect the process of ... Also, thyme extracts can also be employed as an anti - fungal agent on conditions such as Athletes foot and toenail fungal ...

https://vitanetonline.com/forums/search/length/1

Corneal Ulcers, Anti TNF Agents, Cyclopegics/ Ciliary Muscles Relaxants. On the basis of Application, the market is segmented ...

https://www.goerieblogs.com/anterior-uveitis-market-growth-demand-penetration-and-forecast/

Amlexanox is an anti-allergic and anti-inflammatory agent, prescribed for aphthous ulcers or canker sores in people with normal ... Amantadine is a synthetic (man-made) anti-viral and antiparkinson agent, prescribed for Parkinsons disease and also for ... Anti-Inhibitor Coagulant Complex- Vapor Heated Anti-Inhibitor Coagulant Complex- Vapor Heated is a freeze-dried sterile human ... Anti-Inhibitor Coagulant Complex- Heat Treated Anti-Inhibitor Coagulant Complex- Heat Treated is a clotting factor, prescribed ...

https://www.medindia.net/doctors/drug_information/home.asp

Nelson, E. A. and Bradley, M. D. Dressings and topical agents for arterial leg ulcers. Cochrane.Database.Syst.Rev. 2007;: ... A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga Fucus ... Antimicrob Agents Chemother 1988;32:1742-5. View abstract.. *Beress A, Wassermann O, Tahhan S, et al. ... Dressings and topical agents for donor sites of split-thickness skin grafts. JOURNAL 2009;0:0. ...

https://medlineplus.gov/spanish/druginfo/natural/726.html

... of patients with gastric ulcers who do not consume nonsteroidal anti-inflammatory agents (10). However, most H. pylori-infected ... Nevertheless, the possibility that peptic ulcer disease or gastric cancer might be caused by an infectious agent was generally ... Thus, the presence of H. pylori seems necessary for the production of duodenal ulcers, with the exception of ulcers attributed ... In addition, nearly all patients with duodenal ulcer disease have H. pylori gastritis, and ulcer relapse is exceptional after H ...

https://wwwnc.cdc.gov/eid/article/1/3/95-0302_article

... and thus authenticate the use of Nymphaea lotus as an antiulcer agent in traditional medicine.. ... Protective effects of the aqueous extract of Nymphaea lotus L. (Nymphaeaceae) against ethanol-induced gastric ulcers * LB John- ... shows that aqueous extract of Nymphaea lotus contains active ingredients with a therapeutic potential against gastric ulcers, ...

https://www.ajol.info/index.php/ijbcs/article/view/85222

... of patients on exemestane with gastric ulcer received concomitant treatment with non-steroidal anti-inflammatory agents and/or ... Other Estrogen-Containing Agents Advise patients that they should not take estrogen-containing agents while they are taking ... 5.3 Administration with Estrogen-Containing Agents Exemestane should not be coadministered with estrogen-containing agents as ... 5.3 Administration with Estrogen-Containing Agents 5.4 Laboratory Abnormalities 5.5 Use in Premenopausal Women 5.6 Embryo-Fetal ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=15e11379-e681-4f2b-bdd6-dbbe56e563b0&audience=professional

Anti-Ulcer Agents. Registry Number:. 1ISE2Y6ULA CAS Type 1 Name:. 4,8,12-Tetradecatrienoic acid, 5,9,13-trimethyl-, 3,7- ... A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function ... A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function ...

https://decs.bvsalud.org/en/ths/resource/?id=5918

Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue. ... Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/1992 - "It is effective in preventing NSAID-induced ulcers, and does ... not on anti-ulcer therapy or non-steroidal anti-inflammatory drugs) for GP review of eligibility. ". ... Drugs and Important Biological Agents (IBA) related to Ulcer: 1. Omeprazole (Esomeprazole)FDA LinkGeneric 01/01/1989 - "In ...

https://www.curehunter.com/public/keywordSummaryD014456.do

GI Anti-Ulcer Agents, anticholinergic. ChemblDrugs TTD TdgClinicalTrial TEND (1 More Sources) ...

https://dgidb.genome.wustl.edu/drugs/METHANTHELINE

... results supported that quercetin could be a potential therapeutic agent for pressure ulcers. ... Diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin. Exp. Pharmacol. Physiol. 2009, 36, 1149-1156 ... Group 1 was the control group and no topical agent was applied. Group 2 used a base cream only without an effective agent. ... They are oxidizing agents and mayor contributors to cell damage [6,7], but also have beneficial roles and, in particular, play ...

https://www.mdpi.com/2077-0383/10/16/3558

... ulcers; are taking anticoagulant agents, anti-inflammatory agents or antibiotics; or before having surgery. Take a few hours ...

https://www.victoriashealth.com/organika-organika-garcinia-plus-90-caps.html

Other Products in Anti Ulcer, GIT Agent & Antacid category. Digene Acidity & Gas Relief Orange Tablet. Physical Form : ... Recommended For : Antacid, Antiulcer. Dosage : AS DIRECTED BY PHYSICIAN. Drug Type : General Medicines. Suitable For : Suitable ... Recommended For : Antacid, Antiulcer. Dosage : AS DIRECTED BY PHYSICIAN. Drug Type : General Medicines. Suitable For : Suitable ... Recommended For : Antacid, Antiulcer. Dosage : AS DIRECTED BY PHYSICIAN. Drug Type : General Medicines. Suitable For : Suitable ...

https://www.medzeellifescience.com/l-ornithine-l-aspartate-pancreatin-tablet-6566499.html

1 Anti-Ulcer Agents --administratio.... *1 Biopsy. *1 Blood Glucose --analysis. *. < previous next > ... Duodenal ulcer dyspepsia in the first degree relatives of subjects with duodenal ulcer disease.. Raihan, A S; Hasan, M; Ali, S ... Predictors of duodenal ulcer healing in sucralfate treated patients.. Haq, S A; Rahman, M T; Hasan, M; Khan, A K. ... Factors influencing development of bulbar deformity in duodenal ulcer disease.. Haq, S A; Hasan, M; Rahman, M T; Khan, A K. ...

https://imsear.searo.who.int/handle/123456789/7/simple-search?query=&sort_by=score&order=desc&rpp=10&filter_field_1=author&filter_type_1=equals&filter_value_1=Khan%2C+A+K&filter_field_2=subject&filter_type_2=equals&filter_value_2=Humans&filter_field_3=author&filter_type_3=equals&filter_value_3=Hasan%2C+M&etal=0&subject_page=1

Anti-Ulcer Agents (‎1)‎. Capsules (‎1)‎Chemistry, Pharmaceutical (‎1)‎Drug Costs (‎1)‎Drug Stability (‎1)‎... View MoreDate ...

https://apps.who.int/iris/discover?filtertype_0=subject&filter_relational_operator_0=equals&filter_0=Tablets%2C+Enteric-Coated&filtertype=subject&filter_relational_operator=equals&filter=Anti-Ulcer+Agents

Advice for clinicians for diagnosing and treating aphthous ulcers. ... Topical analgesics/anti-inflammatory agents. *Topical analgesic pastes [e.g., 20% benzocaine] (to reduce ulcer pain): apply as ... 0.12% chlorhexidine mouthrinse (to reduce ulcer pain and duration of lesions): rinse b.i.d. for 2 weeks or until ulcers heal ... Benzydamine hydrochloride mouthrinse [e.g., Tantum®] (to reduce ulcer pain): apply q.i.d. for 2 weeks or until ulcers heal ...

https://jcda.ca/article/d48

A corneal ulcer occurs when there is a sore in the layer of the cornea. Symptoms of this include redness, drainage, visual ... Causes and Effects of Corneal Ulcers The most common ... If the corneal ulcer is severe, oral agents may also be ... If the doctor suspects a fungal infection topical anti-fungal medication may be needed. ... Prevention of Corneal Ulcers. The best way to avoid suffering from a corneal ulcer is protection of the eye. When doing any ...

https://blinkcharlotte.com/common-eye-conditions/corneal-ulcer/

H. pylori causes chronic active gastritis and is a major factor in the pathogenesis of duodenal ulcers and, to a lesser extent, gastric ulcers. (cdc.gov)
In addition, gastroenterologists and surgeons noted but could not explain the almost universal presence of antral gastritis in patients with duodenal ulcers and the frequent presence of atrophic gastritis in patients with gastric ulcer and cancer. (cdc.gov)
A similar reaction followed the subsequent demonstration that these Campylobacter -like bacteria were present in almost all patients with gastric and duodenal ulcers, and were generally associated with antral gastritis (9) . (cdc.gov)
Takecab (Vonoprazan Fumarate) is a prescription medicine used to treat gastric or duodenal ulcers, reflux esophagitis, and suppress the recurrence of gastric/duodenal ulcers associated with low-dose aspirin or nonsteroidal anti-inflammatory drug administration. (canadianpharmacyworld.com)
Helicobacter pylori has been shown to be the causative agent in chronic-active gastritis, and evidence has almost completely satisfied Koch's postulates for this organisms' pathogenicity in primary duodenal ulcers. (cdc.gov)

Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear. (researchgate.net)
It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. (lecturio.com)

Crohn's and Colitis can also cause recurrent mouth ulcers which is important to keep an eye on. (dentalhealth.org)
One of the symptoms of mouth cancer is the appearance of ulcers which can be deceiving as Colitis and Crohn's cause mouth ulcers too. (dentalhealth.org)
Podina plays a significant role in alleviating swollen gums, mouth ulcers and toothaches. (foodb.ca)

A pilot study indicated that applying kiwifruit on neuropathic diabetic foot ulcers led to a significant reduction in the size of the foot ulcers and faster wound healing. (greenmedinfo.com)
Diabetic foot ulcers are a common cause of morbidity and mortality in Nigeria . (bvsalud.org)
Deep wound swabs were collected from 71 consecutive diabetic patients admitted with foot ulcers into the medical wards of University of Nigeria Teaching Hospital , Enugu (26% of 274 total diabetes-related admissions). (bvsalud.org)
A recent study published in the Journal of Family Practice reports the case of a 79-year-old man with Type 2 diabetes who developed foot ulcers. (iqsoft.in)
They also recommend random controlled trials to determine efficacy and invite physicians to consider topical honey therapy for patients with refractory diabetic foot ulcers. (iqsoft.in)

It might have some activity against stomach and intestinal ulcers, and heartburn symptoms. (medicinenet.com)
The symptoms of an ulcer vary greatly depending on the location. (lifeafterjob.com)
Non-specific symptoms such as nausea and bloating are also associated with a stomach ulcer. (lifeafterjob.com)
By reducing the gastric acid content, the symptoms of a gastric or duodenal ulcer are relieved by Takecab. (canadianpharmacyworld.com)
The process of diagnosis will depend on your symptoms and the severity of your ulcer. (ulcertalk.com)
This study was conducted to assess the epidemiology and risk factors for acquisition of H. pylori among individuals with and without peptic ulcer symptoms in Owerri, Nigeria, in order to provide baseline data and create awareness for effective management and prevention of infection caused by this pathogen. (who.int)
All patients who are receiving long-term treatment with NSAID agents should be monitored as a precautionary measure (e.g., renal, hepatic function and blood counts).If abnormal liver function tests persist or worsen, clinical signs and symptoms consistent with liver disease develop or if other manifestations occur, Diclofenac sodium should be discontinued. (inceptapharma.com)
Our patient initially presented symptoms compatible with reflux esophagitis, such as heartburn sensation, but later developed high-intensity retrosternal pain and dysphagia, which subsequently correlated with the atypical endoscopic findings of circumferential ulcer with deepithelialization of the mid-esophagus confirmed in the histological examination. (scholars.direct)

Anti-ulcer effect of DG may be due to its cytoprotective effect along with antisecretory activity and could act as a potent therapeutic agent against peptic ulcer disease. (who.int)
These results shows that aqueous extract of Nymphaea lotus contains active ingredients with a therapeutic potential against gastric ulcers, and thus authenticate the use of Nymphaea lotus as an antiulcer agent in traditional medicine. (ajol.info)
Two key effects of curcumin that account for most of the therapeutic effects of this compound are its strong antioxidant and anti-inflammatory properties. (naturalsociety.com)

An overgrowth of the bacterium Helicobacter pylori can contribute to the development of stomach ulcers. (ulcertalk.com)
Helicobacter pylori , which is a causative agent of chronic gastritis, duodenal ulcer and gastric cancer, presently affects approximately one half of the world population. (who.int)
These results do not rule out the possibility of Helicobacter infection as a contributing agent or cofactor in the development of biliary diseases. (who.int)
La présence de l'ADN spécifique du genre Helicobacter (gènes codant l'ARN ribosomique 16S) a été déterminée au moyen de l'amplification en chaîne par polymérase nichée. (who.int)
Ces résultats ne permettent pas d'éliminer la possibilité d'une infection à Helicobacter comme agent favorisant l'apparition des maladies biliaires ou comme cofacteur de leur développement. (who.int)

Methods: We evaluated anti-ulcer potential of plant extract in ethanol-induced ulcer model in rats. (researchgate.net)

Millions of people suffer from gastritis on a daily basis and the problem is that if we leave it untreated, the damage caused to our stomach can generate extreme pain, ulcers, or even cancer. (ulcertalk.com)

Animal studies have shown that increasing melatonin levels by even small amounts can have a dramatic effect in both healing and preventing stress-induced ulcers. (ulcertalk.com)

Contact lens wearers are especially prone to corneal ulcers, especially if they wear their contacts while sleeping or while swimming. (blinkcharlotte.com)

Results: The methanolic extract of Lavandula stoechas L. showed antimicrobial activity against Proteus Mirabilis while the GCMS based analysis revealed the presence of 10 phytochemicals including camphor (antimicrobial agent). (researchgate.net)
The lesions are usually infected, and this study was carried out in Enugu State , Nigeria to determine the common bacterial pathogens that infect ulcers and their antimicrobial susceptibly patterns. (bvsalud.org)
Honey also has antimicrobial properties that can help reduce the spread of infection like stomach ulcers or viral diseases. (rantrovehoney.in)
Antimicrobial agents and chemotherapy 2015 Jun 59 (6): 3240-5. (cdc.gov)

This leads to a stomach ulcer, or gastric ulcer. (lifeafterjob.com)
This remedy has best natural treatment for stomach ulcer. (ulcertalk.com)

Research supports the use of turmeric to soothe the digestive tract and to treat stomach ulcers and ulcerative colitis. (conniepenningtonmd.com)

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever and to relieve pain and swelling in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. (medindia.net)
Horizon Pharma launched the new combination drug under the brand name Duexis in the United States in January 2011 and is marketing it as a more convenient alternative to taking a nonsteroidal anti-inflammatory drug (NSAID) along with a separate gastroprotective agent. (medscape.com)

METHODS: We report the case of an immunosuppressed patient who developed a hydroxyurea-induced leg ulcer with subclinical MRSA infection which was subsequently treated with topical application of manuka honey, without cessation of hydroxyurea or cyclosporin. (greenmedinfo.com)
The most common cause of a corneal ulcer is infection. (blinkcharlotte.com)
If the doctor suspects a fungal infection topical anti-fungal medication may be needed. (blinkcharlotte.com)
infection), avoidance of offending agents, and replacement of associated deficiencies. (lecturio.com)
An infection of the ulcer can also occur, which often leads to an accumulation of pus. (lifeafterjob.com)
For example, if an ulcer becomes infected due to a bacterial infection, the body sends defense cells to the ulcer. (lifeafterjob.com)
The sero-prevalence of H. pylori infection among the study participants was 72.4% (285/384) while the prevalence of ulcer by FOB test was 71.1% (273/384). (who.int)

Genetic and environmental predictors of chronic kidney disease in patients with type 2 diabetes and diabetic foot ulcer: a pilot study. (cdc.gov)
Becker chose amputate candidates for his research on chronic ulcers and NEVER lost a limb. (earthpulse.net)
The histopathological study showed an ulcer fund compatible with chronic ulcerated esophagitis with no epithelial representation in the sample (Figure 1d). (scholars.direct)

Manuka honey appears to be an effective antibacterial wound healing agent against MRSA-colonized leg ulcers. (greenmedinfo.com)
Antiulcer drugs are a class of drugs exclusive of the antibacterial agents, used to treat ulcers in the stomach and the upper part of the small intestine. (tropilab.com)
Withania somnifera has been used as an antioxidant, adaptogen, aphrodisiac, liver tonic, anti-inflammatory agent and astringent and more recently as an antibacterial, antihyperplycemic and antitumoral, as well as to treat ulcers and senile dementia ( Rastogi and Mehrotra, 1998 ). (scialert.net)
Withaferin A and 3-β-hydroxy-2, 3 dihydro withanolide F show promising antibacterial, antitumour, immunomodulating and anti-inflammatory properties. (scialert.net)
The active ingredient in turmeric is curcumin which is a natural antiseptic and antibacterial agent. (conniepenningtonmd.com)
A study of the use of free silver ions as an antibacterial and antifungal agent administered to infected local wounds has been conducted over the past two decades. (earthpulse.net)

Effective treatment for eczema, psoriasis, and skin ulcers is provided by karanja oil. (speakingtree.in)

However, the ability of RAGE to alter numerous cell signal pathways associated with both IL-6 expression and IL-6 cell signaling suggest that RAGE and IL-6 have important roles in both delayed diabetic wound healing and diabetic ulcers. (cdc.gov)

Sea buckthorn leaves and flowers are used for treating arthritis , gastrointestinal ulcers, gout , and skin rashes caused by infectious diseases such as measles . (medicinenet.com)

2. The patient has another disease/condition that requires constant use of non-topical analgesics and/or anti-inflammatory agents or, in the opinion of the investigator, disturbs the patient's perception of postoperative pain. (who.int)

It serves as a good blood cleanser, since it is antiseptic and anti-bacterial. (foodb.ca)

Helps fight against allergies, reduces inflammation and wounds including leg ulcers and sore throats. (rantrovehoney.in)
Treatment Disruption of the confirmed by taking a presence of ulcers, wounds, that something could be. (impelits.com)

The present study was designed to investigate anti-ulcerogenic property of ethanolic extract of Desmodium gangeticum (DG) against cold restraint (CRU, 2 hr cold restraint stress), aspirin (ASP, 150 mg/kg orally), alcohol (AL, absolute alcohol 1 ml/200gm) and pyloric ligation (PL, 4 hr pylorus ligation) induced gastric ulcer models in Sprague Dawley rats, and histamine (HST, 0.25 mg/kg) induced duodenal ulcer in guinea pigs. (who.int)
We targeted the gastro-protective potential and probable mechanism of OLM and its niosomal form against indomethacin (IND) induced-gastric ulcer in rats. (bvsalud.org)
In rats, it has inhibited ulcers. (dietarious.com)

BACKGROUND: With the everincreasing emergence of antibiotic-resistant pathogens, in particular methicillin-resistant Staphylococcus aureus (MRSA) in leg ulcers, a means of reducing the bacterial bioburden of such ulcers, other than by the use of either topical or systemic antibiotics, is urgently required. (greenmedinfo.com)
If, on the other hand, the ulcer is in the gastrointestinal tract, for example, circulatory disorders as well as bacterial causes and an imbalance in the digestive enzymes are possible causes. (lifeafterjob.com)
But even without bacterial colonization, an ulcer can begin to smell. (lifeafterjob.com)
Ginger has anti-bacterial and anti-inflammatory properties. (ulcertalk.com)
As we all honey contain anti-bacterial properties, so this may also help to reduce the risk of hyperacidity. (ulcertalk.com)
Naturally anti-bacterial Bhuvika Pungam oil Soap in Komarapalayam protects your skin from pathogenic microorganisms. (speakingtree.in)
Since the traditional fruit contains anti-bacterial properties and ability to inhibit both peptic and gastric stomach ulcers. (ulcertalk.com)
Its extract contains nearly 300 compounds that have antiviral [1], anti-bacterial, and anti-inflammatory properties. (apimemphis.com)

Beginning at the turn of the 20th century, similar spiral bacteria were found in gastrectomy specimens from patients with gastric cancer and peptic ulcer disease ( 3 , 4 ). (cdc.gov)
Nevertheless, the possibility that peptic ulcer disease or gastric cancer might be caused by an infectious agent was generally discounted. (cdc.gov)

It can also be used to treat gastric disorders, including ulcers. (rantrovehoney.in)

Patients who suffer from frequent, recurrent episodes of aphthous ulcers should be referred to either an oral medicine/oral pathology specialist or their physician to rule out any possible systemic association with recurrent aphthous stomatitis. (jcda.ca)

IMSEAR at SEARO: Desmodium gangeticum: a potent anti-ulcer agent. (who.int)
The observation made in 1975 that gram-negative bacteria were present in 80% of patients with gastric ulcer (5) was largely ignored by the scientific community which, at the time, was busily developing potent antiulcer agents (6) . (cdc.gov)
Olmesartan (OLM) has potent anti-oxidant and anti-inflammatory characters, yet having limited bioavailability. (bvsalud.org)
The role of IL-6 as a potent anti-inflammatory agent in irritant dermatitis is an important observation. (cdc.gov)
Turmeric is quickly becoming a well known potent anti-inflammatory spice. (naturalsociety.com)
Diclofenac is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID) with marked analgesic and antipyretic properties. (inceptapharma.com)

They are used as anti-ulcer agents and sometimes in place of histamine h2 antagonists for gastroesophageal reflux. (lecturio.com)

New research on the ability of Turneraceae (family to which Damiana belongs) to avoid ulceration of the gastric and duodenal mucosa, suggests that the flavonoids present in Damiana have a significant anti-ulcerogenic effect . (tropilab.com)
There have been many attempts over the years to find an effective treatment for oral ulceration and localized topical regimens are considered to be the standard treatment for mild cases of oral ulcers. (bvsalud.org)

If an ulcer does not heal well, part of the superficial tissue dies, which can cause the ulcer to turn black. (lifeafterjob.com)
If you have an ulcer which does not heal within 3 weeks, you should make an appointment with your dentist, so that he can look at it. (dentalhealth.org)

It was also used as an aphrodisiac, antidote for numerous toxic agents along with various pharmacological uses. (ayurvedicoils.com)

0.01) ulcers when compared with controls. (researchgate.net)
0.01) more improvement in ulcer scores at the end of the study compared with controls. (curehunter.com)

An ulcer (technical term: ulcer) refers to defects in the skin or the mucous membrane that also affects deeper tissue layers. (lifeafterjob.com)
The oral mucous membrane is prone to developing ulcers originating from traumatic or immunological processes. (bvsalud.org)

Acetaminophen and hydrocodone is a combination of non-opioid and narcotic or sleep-inducing agents used to treat moderate to severe pain associated with inflammation. (medindia.net)
SIGNIFICANCE: We explored OLM anti-ulcerative effects, implicating oxidative stress and inflammation improvement, mediated by the Nrf2/HO-1 signaling pathway and p38-MAPK translocation. (bvsalud.org)
This can lead to painful mouth sores, areas of inflammation and ulcers called stomatitis . (acco.org)
Honey is an anti-inflammatory and antioxidant, which means it helps to reduce the inflammation caused by allergies. (rantrovehoney.in)
Honey is a natural anti-inflammatory agent that can help with arthritis, allergies and skin inflammation. (rantrovehoney.in)

Numerous studies have found the anti-inflammatory herb licorice to be an effective anti-ulcer compound. (ulcertalk.com)
The mulberry tree (Morus macroura) fruit is attaining increased importance for its antioxidant and anti-inflammatory activity in addition to its high safety profile. (bvsalud.org)
Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions. (hindawi.com)
Because of its astringent and anti-inflammatory qualities, it may also be used for piles. (speakingtree.in)
Because of its anti-inflammatory properties, karanja oil is also beneficial for arthritis. (speakingtree.in)
The anti-inflammatory actions of the extract and the fraction may be due to an inhibitory effect on histamine and cyclooxygenase II. (tropilab.com)
Anti-inflammatory studies were conducted using a crude hydroalcoholic extract of the aerial parts of Turnera and its partitioned fractions, i.e. the aqueous, ethyl acetate and ethanolic fractions. (tropilab.com)
Coconut oil has been demonstrated to have anti-inflammatory, analgesic and fever-reducing properties. (crazygoodcreations.com)
Nonsteroidal anti-inflammatory drugs such as aspirin and ibuprofen, cortisone derivatives, and alcohol have all been linked to ulcer development. (ulcertalk.com)
Nonsteroidal anti-inflammatory drugs are used in patients with arthralgia and fatigue, but may be contraindicated in patients with renal disease. (medscape.com)
The tongues were removed, fixed, routinely processed for hematoxylin-eosin staining and analyzed by two blind, calibrated pathologists for the presence or absence of ulcer, inflammatory infiltrate and neutrophils. (bvsalud.org)
Conclusions: Oral ulcers treated with a papainbased gel exhibited the same inflammatory reaction and healing aspects as those of the nontreated control group. (bvsalud.org)
It is also a wonderful anti-inflammatory for joint pain such as osteoarthritis. (conniepenningtonmd.com)
1. Hypersensitivity or allergic reactions/conditions associated with ketorolac, pitofenone, fenpiverinium, any other components of IMPs, acetylsalicylic acid or other non-steroidal anti-inflammatory drugs. (who.int)
Anti-inflammatory effect - according to recent studies, both healthy individuals as well as patients with gastrointestinal complaints benefit of cayenne pepper supplementation. (dietarious.com)

After 5 h of disease induction, animals were sacrificed to get tissues for histological evaluation and ulcer index was measured. (researchgate.net)
Aim: The aim of the present study was to perform a histological evaluation of the antiinflammatory and healing properties of PapacarieTM applied to oral ulcers. (bvsalud.org)
The purpose of this study was to perform a histological evaluation of the antiinflammatory and healing properties of this papain-based gel applied to oral ulcers. (bvsalud.org)
Histological aspect of esophageal ulcer without epithelial representation. (scholars.direct)

If the corneal ulcer was caused by bacteria the doctor will likely prescribe a topical antibiotic for the eye. (blinkcharlotte.com)

Necrotic tissue usually develops on an ulcer after some time, when the body cannot close the defect again. (lifeafterjob.com)
It can be used as phytotherapic agent to remove damaged or necrotic tissue in the treatment of pressure ulcers, gangrene and eschars and as a debriding chemical agent. (bvsalud.org)

Depending on the aggressiveness of this problem you might experience stomach pain, abdominal bloating, burning sensations, ulcers, and much more. (ulcertalk.com)

DOI: 10.3201/eid1604.080483 destruction of skin and soft tissue with became a large ulcer 15 cm in diameter the formation of large ulcers ( 2 ). (cdc.gov)
If the ulcers can be found on the skin, poor blood circulation in the tissue is usually the reason for the defect. (lifeafterjob.com)
The other way around, an ulcer can become infected and thus bring pathogens into deeper tissue layers, where an abscess then develops. (lifeafterjob.com)
New tissue appeared within two weeks, with the ulcers healing completely in six to 12 months. (iqsoft.in)
Robert O. Becker: Regeneration of tissue in diabetic ulcer. (earthpulse.net)

In his book, The Green Pharmacy, medical botanist, James Duke, mentions that ginger contains 11 anti-ulcer compounds. (ulcertalk.com)
Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS . (bvsalud.org)

DG showed significant protection against CRU (68.37%), AL (88.87%), ASP (38.2%), PL (40.63%) and HST (63.15%) induced ulcer models, whereas standard drug omeprazole (OMZ) showed protection index of 83.86, 56.35, 70.31 and 84.21%, respectively in CRU, ASP, PL and HST models. (who.int)

Yet only 25% of physicians prescribe gastroprotective agents in patients at high risk for ulcers from their NSAIDs, and only 25% of patients continue taking the gastroprotective medication after their third refill, said Dr. Magelli. (medscape.com)
But he agreed that more needs to be done to address the problem of gastrointestinal bleeding in patients at risk for ulcers who are taking NSAIDs. (medscape.com)

Compared with patients taking only ibuprofen, half as many patients taking the combination drug had endoscopically observed ulcers after 24 weeks, researchers reported here at PAINWeek, a conference of pain specialists. (medscape.com)
She argued that a combination agent could also be cheaper for patients with medical benefits because they could get 1 prescription and owe only a single copayment of $20 per month. (medscape.com)
At the meeting, Dr. Magelli reported on the combined results of 2 clinical trials, REDUCE-1 and REDUCE-2 (Registration Endoscopic Studies to Determine Ulcer Formation of HZT-501 Compared with Ibuprofen: Efficacy and Safety Studies), in which a total of 930 patients took the combination agent and 452 took ibuprofen. (medscape.com)
About 6% of patients had prior ulcers, and 16% of the combination therapy group was taking low-dose aspirin, compared with 12.8% of the ibuprofen group. (medscape.com)
These results provide a promising step that might encourage further investigations of MFE as a protective agent in UC patients. (bvsalud.org)
Rituximab (anti-CD20 chimeric monoclonal antibody) has shown promise in controlling vasculitis, peripheral neuropathy, arthralgias, low-grade B cell lymphomas, renal disease, and fever, specifically in patients with hepatitis C virus/related mixed cryoglobulinemia that is refractory to or unsuitable for corticosteroids and antiviral therapy. (medscape.com)
In addition, patients with malabsorption syndrome, gall bladder problems, gastric ulcer, bleeding problems as well as those who are undergoing surgery, and those who have a history of hypersensitivity to herbal products should be cautious and consult with their physician before taking this supplement. (naturalsociety.com)

Treatment and prophylaxis of peptic ulcer and gastric hypersecretory conditions such as Zollinger-Ellison syndrome. (unboundmedicine.com)
Objectives: We aimed to evaluate the pharmacological potential of Lavandula stoechas L. extracts for anti-ulcer activity, and compare with the standard drugs and to explore novel treatment for peptic ulcer. (researchgate.net)
After 2 weeks of treatment, the for Disease Prevention and Control, Manila ulcerans disease (Buruli ulcer) is a size of the large ulcer had increased. (cdc.gov)
Food-borne tion treatment of rifampin/streptomy- of an ulcer on the left wrist. (cdc.gov)
It is highly recommended to begin treatment as soon as you observe the onset of stomach ulcers. (ulcertalk.com)
The accompanying page on drugs used in the treatment of pediatric cancers lists which of these side effects are more likely to be experienced with each chemotherapy agent. (acco.org)
Some chemotherapy agents are more likely than others to cause hair loss several weeks after starting treatment. (acco.org)
Teeth treatment with fluoride agents like gel or rinse. (gentledentalpc.com)
It is used as an anti-aging treatment as well. (bevu.in)

History - It is important for you to inform your doctor about your past medical and surgical history, your current regular medication especially blood thinning agents, such as aspirin, warfarin and drug allergy. (singhealth.com.sg)

Since propolis-containing products have been marketed and humans have used propolis for different purposes, the goal of this review is to discuss the potential of propolis for the development of new drugs, by comparing data from the literature that suggest candidate areas for the establishment of drugs against tumors, infections, allergy, diabetes, ulcers and with immunomodulatory action. (blogspot.com)

Corticosteroids (high-potency topical agents usually in combination with antifungal prophylaxis and/or systemic medication). (jcda.ca)

If the corneal ulcer is severe, oral agents may also be prescribed. (blinkcharlotte.com)
While mild to moderate ulcers may be healed with the remedies given here, severe cases need medical attention. (ulcertalk.com)
Despite its size, an oral ulcer can cause mild to severe pain. (bvsalud.org)

The animals were anesthetized, placed in prone position and ulcers were induced in the middle dorsum of the tongue through a 3-mm-diameter punch. (bvsalud.org)

Based on the clinical examination and on the patient's medical history, a diagnosis of aphthous ulcers is determined. (jcda.ca)
The diagnosis of an ulcer is usually a visual diagnosis. (lifeafterjob.com)

Our Canadian Pharmacy also carries other ulcer/GERD medications at huge savings. (canadianpharmacyworld.com)

It is an effective agent in controlling gum diseases. (gentledentalpc.com)

Anatomy16

Organisms14

Diseases52

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes27

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Information Science5

Named Groups1

Health Care17

Geographicals4

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (1/1640)

Can restrictions on reimbursement for anti-ulcer drugs decrease Medicaid pharmacy costs without increasing hospitalizations? (2/1640)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (3/1640)

Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. (4/1640)

Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. (5/1640)

Maleic acid and succinic acid in fermented alcoholic beverages are the stimulants of gastric acid secretion. (6/1640)

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole. (7/1640)

Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels. (8/1640)

Stomach Ulcer

Duodenal Ulcer

Peptic Ulcer

Leg Ulcer

Pressure Ulcer

Skin Ulcer

Peptic Ulcer Hemorrhage

Peptic Ulcer Perforation

Buruli Ulcer

Diabetic Foot

Helicobacter pylori

Anti-Ulcer Agents

Helicobacter Infections

Mycobacterium ulcerans

Cimetidine

Bandages

Tropaeolaceae

Vagotomy, Proximal Gastric

Gastric Acid

Gastric Juice

Omeprazole

Ranitidine

Stereoisomerism

Vagotomy

Gastritis

Stomach

Acetic Acid

Gastroscopy

Duodenoscopy

Histamine H2 Antagonists

Magnetic Resonance Spectroscopy

Nucleic Acid Conformation

Anti-Inflammatory Agents, Non-Steroidal

Recurrence

Gastrins

Plant Extracts

Pylorus

Molecular Structure

Dyspepsia

Molecular Conformation

Hemostasis, Endoscopic

Models, Molecular

Treatment Outcome

Gastrointestinal Hemorrhage

Proton Pump Inhibitors

Antacids

Venous Insufficiency

Hydrogen Bonding

Amoxicillin

Duodenum

Dumping Syndrome

Antibodies, Monoclonal

Bismuth

Guanine

Esophageal Diseases

Heterocyclic Compounds, Bridged-Ring

Time Factors

Nursing Assessment

Beds

Famotidine

2-Pyridinylmethylsulfinylbenzimidazoles

Endoscopy

Gastroenterostomy

Prospective Studies

Base Pairing

Phytotherapy

Stomatitis, Aphthous

India

Pachyrhizus

Debridement

Deoxyguanosine

Metronidazole

Clarithromycin

Chancroid

Antibodies

Occlusive Dressings

Gastric Acidity Determination

Lansoprazole

Immunoglobulin G

DNA