Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Duodenal Ulcer: A PEPTIC ULCER located in the DUODENUM.Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.Pressure Ulcer: An ulceration caused by prolonged pressure on the SKIN and TISSUES when one stays in one position for a long period of time, such as lying in bed. The bony areas of the body are the most frequently affected sites which become ischemic (ISCHEMIA) under sustained and constant pressure.Skin UlcerPeptic Ulcer Hemorrhage: Bleeding from a PEPTIC ULCER that can be located in any segment of the GASTROINTESTINAL TRACT.Peptic Ulcer Perforation: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.Buruli Ulcer: A lesion in the skin and subcutaneous tissues due to infections by MYCOBACTERIUM ULCERANS. It was first reported in Uganda, Africa.Diabetic Foot: Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Anti-Ulcer Agents: Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Mycobacterium ulcerans: A slow-growing mycobacterium that infects the skin and subcutaneous tissues, giving rise to indolent BURULI ULCER.Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.Bandages: Material used for wrapping or binding any part of the body.Tropaeolaceae: A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.Vagotomy, Proximal Gastric: Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. Since the procedure leaves the vagal branches to the antrum and PYLORUS intact, it circumvents gastric drainage required with truncal vagotomy techniques.Gastric Acid: Hydrochloric acid present in GASTRIC JUICE.Gastric Juice: The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Ranitidine: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Vagotomy: The interruption or removal of any part of the vagus (10th cranial) nerve. Vagotomy may be performed for research or for therapeutic purposes.Gastritis: Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.Stomach: An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Gastroscopy: Endoscopic examination, therapy or surgery of the interior of the stomach.Duodenoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the duodenum.Histamine H2 Antagonists: Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Recurrence: The return of a sign, symptom, or disease after a remission.Gastrins: A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Pylorus: The region of the STOMACH at the junction with the DUODENUM. It is marked by the thickening of circular muscle layers forming the pyloric sphincter to control the opening and closure of the lumen.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Dyspepsia: Impaired digestion, especially after eating.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Hemostasis, Endoscopic: Control of bleeding performed through the channel of the endoscope. Techniques include use of lasers, heater probes, bipolar electrocoagulation, and local injection. Endoscopic hemostasis is commonly used to treat bleeding esophageal and gastrointestinal varices and ulcers.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Regeneration: The physiological renewal, repair, or replacement of tissue.Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Proton Pump Inhibitors: Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.Antacids: Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.Venous Insufficiency: Impaired venous blood flow or venous return (venous stasis), usually caused by inadequate venous valves. Venous insufficiency often occurs in the legs, and is associated with EDEMA and sometimes with VENOUS STASIS ULCERS at the ankle.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Duodenum: The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.Dumping Syndrome: Gastrointestinal symptoms resulting from an absent or nonfunctioning pylorus.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Bismuth: A metallic element that has the atomic symbol Bi, atomic number 83 and atomic weight 208.98.GuanineEsophageal Diseases: Pathological processes in the ESOPHAGUS.Heterocyclic Compounds, Bridged-Ring: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Nursing Assessment: Evaluation of the nature and extent of nursing problems presented by a patient for the purpose of patient care planning.Beds: Equipment on which one may lie and sleep, especially as used to care for the hospital patient.Clione: A genus of small, shell-less, marine mollusks in the family Clione, superorder GASTROPODA. These pteropod (possessing a foot developed into wing-like organ for swimming) sea slugs feed exclusively on another pteropod mollusk, Limacina.2-Pyridinylmethylsulfinylbenzimidazoles: Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.Endoscopy: Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.Gastroenterostomy: A variety of surgical reconstructive procedures devised to restore gastrointestinal continuity, The two major classes of reconstruction are the Billroth I (gastroduodenostomy) and Billroth II (gastrojejunostomy) procedures.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Base Pairing: Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Stomatitis, Aphthous: A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)IndiaPachyrhizus: A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).Debridement: The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)Deoxyguanosine: A nucleoside consisting of the base guanine and the sugar deoxyribose.Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).Clarithromycin: A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.Chancroid: Acute, localized autoinoculable infectious disease usually acquired through sexual contact. Caused by HAEMOPHILUS DUCREYI, it occurs endemically almost worldwide, especially in tropical and subtropical countries and more commonly in seaports and urban areas than in rural areas.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Occlusive Dressings: Material, usually gauze or absorbent cotton, used to cover and protect wounds, to seal them from contact with air or bacteria. (From Dorland, 27th ed)Gastric Acidity Determination: Gastric analysis for determination of free acid or total acid.Lansoprazole: A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Deoxycytosine Nucleotides: Cytosine nucleotides which contain deoxyribose as the sugar moiety.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Haemophilus ducreyi: A species of HAEMOPHILUS that appears to be the pathogen or causative agent of the sexually transmitted disease, CHANCROID.Guanosine: A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)Hematemesis: Vomiting of blood that is either fresh bright red, or older "coffee-ground" in character. It generally indicates bleeding of the UPPER GASTROINTESTINAL TRACT.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Pentagastrin: A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Magnesium Hydroxide: An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.G-Quadruplexes: Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)Gastrointestinal Diseases: Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Duodenitis: Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.Melena: The black, tarry, foul-smelling FECES that contain degraded blood.Mycobacterium Infections, Nontuberculous: Infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae.Pepsinogens: Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Amputation: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Oligodeoxyribonucleotides: A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.Deoxyadenine Nucleotides: Adenine nucleotides which contain deoxyribose as the sugar moiety.Compression Bandages: Strips of elastic material used to apply pressure to body parts to control EDEMA and aid circulation.Inosine: A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)Glycyrrhiza: A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Nursing Evaluation Research: Research carried out by nurses that uses interviews, data collection, observation, surveys, etc., to evaluate nursing, health, clinical, and nursing education programs and curricula, and which also demonstrates the value of such evaluation.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Stomach Neoplasms: Tumors or cancer of the STOMACH.Sulfolobus solfataricus: A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Rectal Diseases: Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Organometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Foot Diseases: Anatomical and functional disorders affecting the foot.Gefarnate: A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.Tongue DiseasesHydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Duodenal Diseases: Pathological conditions in the DUODENUM region of the small intestine (INTESTINE, SMALL).Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Skin Diseases, Bacterial: Skin diseases caused by bacteria.Base Composition: The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Deoxyadenosines: Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.Cysteamine: A mercaptoethylamine compound that is endogenously derived from the COENZYME A degradative pathway. The fact that cysteamine is readily transported into LYSOSOMES where it reacts with CYSTINE to form cysteine-cysteamine disulfide and CYSTEINE has led to its use in CYSTINE DEPLETING AGENTS for the treatment of CYSTINOSIS.Drug Incompatibility: The quality of not being miscible with another given substance without a chemical change. One drug is not of suitable composition to be combined or mixed with another agent or substance. The incompatibility usually results in an undesirable reaction, including chemical alteration or destruction. (Dorland, 27th ed; Stedman, 25th ed)Aluminum Hydroxide: A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc.Isomerism: The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.ShoesDiabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)Benin: A republic in western Africa, south of NIGER and between TOGO and NIGERIA. Its capital is Porto-Novo. It was formerly called Dahomey. In the 17th century it was a kingdom in the southern area of Africa. Coastal footholds were established by the French who deposed the ruler by 1892. It was made a French colony in 1894 and gained independence in 1960. Benin comes from the name of the indigenous inhabitants, the Bini, now more closely linked with southern Nigeria (Benin City, a town there). Bini may be related to the Arabic bani, sons. (From Webster's New Geographical Dictionary, 1988, p136, 310 & Room, Brewer's Dictionary of Names, 1992, p60)Witchcraft: An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3d ed)2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Lissamine Green Dyes: Green dyes containing ammonium and aryl sulfonate moieties that facilitate the visualization of tissues, if given intravenously. They have mostly been used in the study of kidney physiology.Urease: An enzyme that catalyzes the conversion of urea and water to carbon dioxide and ammonia. EC 3.5.1.5.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.DNA Polymerase beta: A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Dinucleoside Phosphates: A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Zollinger-Ellison Syndrome: A syndrome that is characterized by the triad of severe PEPTIC ULCER, hypersecretion of GASTRIC ACID, and GASTRIN-producing tumors of the PANCREAS or other tissue (GASTRINOMA). This syndrome may be sporadic or be associated with MULTIPLE ENDOCRINE NEOPLASIA TYPE 1.Eye Infections, Bacterial: Infections in the inner or external eye caused by microorganisms belonging to several families of bacteria. Some of the more common genera found are Haemophilus, Neisseria, Staphylococcus, Streptococcus, and Chlamydia.Hyperbaric Oxygenation: The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.Ileal Diseases: Pathological development in the ILEUM including the ILEOCECAL VALVE.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.PhotochemistryOligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Skin, Artificial: Synthetic material used for the treatment of burns and other conditions involving large-scale loss of skin. It often consists of an outer (epidermal) layer of silicone and an inner (dermal) layer of collagen and chondroitin 6-sulfate. The dermal layer elicits new growth and vascular invasion and the outer layer is later removed and replaced by a graft.Clinical Nursing Research: Research carried out by nurses in the clinical setting and designed to provide information that will help improve patient care. Other professional staff may also participate in the research.Wound Infection: Invasion of the site of trauma by pathogenic microorganisms.Calymmatobacterium: A genus of bacteria causing GRANULOMA INGUINALE and other granulomatous lesions.Eye Infections, Fungal: Infection by a variety of fungi, usually through four possible mechanisms: superficial infection producing conjunctivitis, keratitis, or lacrimal obstruction; extension of infection from neighboring structures - skin, paranasal sinuses, nasopharynx; direct introduction during surgery or accidental penetrating trauma; or via the blood or lymphatic routes in patients with underlying mycoses.Electrocoagulation: Procedures using an electrically heated wire or scalpel to treat hemorrhage (e.g., bleeding ulcers) and to ablate tumors, mucosal lesions, and refractory arrhythmias. It is different from ELECTROSURGERY which is used more for cutting tissue than destroying and in which the patient is part of the electric circuit.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Bacteriorhodopsins: Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)Bungarus: A genus of poisonous snakes of the subfamily Elapinae of the family ELAPIDAE. They comprise the kraits. Twelve species are recognized and all inhabit southeast Asia. They are considered extremely dangerous. (Moore: Poisonous Snakes of the World, 1980, p120)Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Molecular Mimicry: The structure of one molecule that imitates or simulates the structure of a different molecule.Mucin-1: Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Upper Gastrointestinal Tract: The segment of GASTROINTESTINAL TRACT that includes the ESOPHAGUS; the STOMACH; and the DUODENUM.Kinetics: The rate dynamics in chemical or physical systems.Pepsin A: Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Mice, Inbred BALB CIschemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Ghana: A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.Vulvar Diseases: Pathological processes of the VULVA.Secretory Rate: The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.

Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. (1/1640)

OBJECTIVE: To assess intermittent treatment over 12 months in patients with symptomatic gastro-oesophageal reflux disease. DESIGN: Randomised, multicentre, double blind, controlled study. Patients with heartburn and normal endoscopy results or mild erosive changes received omeprazole 10 mg or 20 mg daily or ranitidine 150 mg twice daily for 2 weeks. Patients remaining symptomatic had omeprazole 10 mg or ranitidine dose doubled for another 2 weeks while omeprazole 20 mg was continued for 2 weeks. Patients who were symptomatic or mildly symptomatic were followed up for 12 months. Recurrences of moderate or severe heartburn during follow up were treated with the dose which was successful for initial symptom control. SETTING: Hospitals and primary care practices between 1994 and 1996. SUBJECTS: 677 patients with gastro-oesophageal reflux disease. MAIN OUTCOME MEASURES: Total time off active treatment, time to failure of intermittent treatment, and outcomes ranked from best to worst. RESULTS: 704 patients were randomised, 677 were eligible for analyses; 318 reached the end of the study with intermittent treatment without recourse to maintenance antisecretory drugs. The median number of days off active treatment during follow up was 142 for the entire study (281 for the 526 patients who reached a treatment related end point). Thus, about half the patients did not require treatment for at least 6 months, and this was similar in all three treatment groups. According to outcome, 378 (72%) patients were in the best outcome ranks (no relapse or one (or more) relapse but in remission until 12 months); 630 (93%) had three or fewer relapses in the intermittent treatment phase. Omeprazole 20 mg provided faster relief of heartburn. The results were similar in patients with erosive and non-erosive disease. CONCLUSIONS: Intermittent treatment is effective in managing symptoms of heartburn in half of patients with uncomplicated gastro-oesophageal reflux disease. It is simple and applicable in general practice, where most patients are seen.  (+info)

Can restrictions on reimbursement for anti-ulcer drugs decrease Medicaid pharmacy costs without increasing hospitalizations? (2/1640)

OBJECTIVE: To examine the impact of a policy restricting reimbursement for Medicaid anti-ulcer drugs on anti-ulcer drug use and peptic-related hospitalizations. DATA SOURCES/STUDY SETTING: In addition to U.S. Census Bureau data, all of the following from Florida: Medicaid anti-ulcer drug claims data, 1989-1993; Medicaid eligibility data, 1989-1993; and acute care nonfederal hospital discharge abstract data (Medicaid and non-Medicaid), 1989-1993. STUDY DESIGN: In this observational study, a Poisson multiple regression model was used to compare changes, after policy implementation, in Medicaid reimbursement for prescription anti-ulcer drugs as well as hospitalization rates between pre- and post-implementation periods in Medicaid versus non-Medicaid patients hospitalized with peptic ulcer disease. PRINCIPAL FINDINGS: Following policy implementation, the rate of Medicaid reimbursement for anti-ulcer drugs decreased 33 percent (p < .001). No associated increase occurred in the rate of Medicaid peptic-related hospitalizations. CONCLUSIONS: Florida's policy restricting Medicaid reimbursement for anti-ulcer drugs was associated with a substantial reduction in outpatient anti-ulcer drug utilization without any significant increase in the rate of hospitalization for peptic-related conditions.  (+info)

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (3/1640)

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.  (+info)

Anti-ulcer effects of 4'-(2-carboxyetyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (cetraxate) on various experimental gastric ulcers in rats. (4/1640)

Anti-ulcer effects of cetraxate, a new compound possessing anti-plasmin, anti-casein and anti-trypsin actions were investigated by using experimental gastric ulcer models in rats. Cetraxate, 300 mg/kg p.o. showed significant inhibitory effects of 65.3%, 70.0%, 30.2%, and 67.1% against aucte types of ulcers producing by aspirin, phenylbutazone, indomethacin, and pyloric ligature (Shay's ulcer), respectively. These effects were greater than those obtained by gefarnate and aluminum sucrose sulfate may be mainly attributed to the protecting action of this drug on gastric mucosa. Ctraxate further revealed remarkable inhibitory effects on chronic types of ulcers produced by acetic acid, clamping, and clamping-cortisone. In acetic acid ulcer in particular, cetraxate was found to have a dose-dependent inhibitory effect at doses over 50 mg/kg. Of test drugs including L-glutamine and methylmethionine sulfonium chloride, cetraxate showed the most remarkable inhibitory effect on beta-glucuronidase activity in ulcer tissue of these three types of ulcers. These findings suggest that cetraxate may prevent the connective tissue in the ulcer location from decomposition due to lysosomal enzymes such as beta-glucuronidase, thereby accelerating the recovery from ulcer.  (+info)

Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. (5/1640)

1. This study used intravital microscopy to investigate the receptors stimulated by amylin which shares around 50% sequence homology with the vasodilator calcitonin gene-related peptide (CGRP) in the hamster cheek pouch microvasculature in vivo. 2. Receptor agonists dilated arterioles (diameters 20-40 microm). The -log of the concentrations (+/- s.e.mean; n = 8) causing 50% increase in arteriole diameter were: human betaCGRP (10.8 +/- 0.3), human alphaCGRP (10.8 +/- 0.4), rat alphaCGRP (10.4 +/- 0.3). Rat amylin and the CGRP2 receptor selective agonist [Cys(ACM2,7]-human alphaCGRP were 100 fold less potent (estimates were 8.5 +/- 0.4 and 8.2 +/- 0.3 respectively). 3. The GCRP1 receptor antagonist, CGRP8-37 (300 nmol kg(-1); i.v.) reversibly inhibited the increase in diameter evoked by human alphaCGRP (0.3 nM) from 178 +/- 22% to 59 +/- 12% (n = 8; P < 0.05) and by rat amylin (100 nM) from 138 +/- 23% to 68 +/- 24% (n = 6; P < 0.05). CGRP8-37 did not inhibit vasodilation evoked by substance P (10 nM; n = 4: P > 0.05). 4. The amylin receptor antagonist, amylin8-37 (300 nmol kg(-1); i.v.) did not significantly inhibit the increase in diameter evoked by human alphaCGRP (0.3 nM) which was 112 +/- 26% in the absence, and 90 +/- 29% in the presence of antagonist (n = 4; P < 0.05); nor that evoked by rat amylin (100 nM) which was 146 +/- 23% in the absence and 144 +/- 32% in the presence of antagonist (n = 4; P > 0.05). 5. The agonist profile for vasodilatation and the inhibition of this dilatation by CGRP8-37, although not the amylin8-37 indicates that amylin causes vasodilatation through interaction with CGRP1 receptors in the hamster cheek pouch.  (+info)

Maleic acid and succinic acid in fermented alcoholic beverages are the stimulants of gastric acid secretion. (6/1640)

Alcoholic beverages produced by fermentation (e.g., beer and wine) are powerful stimulants of gastric acid output and gastrin release in humans. The aim of this study was to separate and specify the gastric acid stimulatory ingredients in alcoholic beverages produced by fermentation. Yeast-fermented glucose was used as a simple model of fermented alcoholic beverages; it was stepwise separated by different methods of liquid chromatography, and each separated solution was tested in human volunteers for its stimulatory action on gastric acid output and gastrin release. Five substances were detected by high-performance liquid chromatography and were analyzed by mass spectrometry and 1H-13C nuclear magnetic resonance spectroscopy. At the end of the separation process of the five identified substances, only the two dicarboxylic acids, maleic acid and succinic acid, had a significant (P < 0.05) stimulatory action on gastric acid output (76% and 70% of fermented glucose, respectively), but not on gastrin release. When given together, they increased gastric acid output by 100% of fermented glucose and by 95% of maximal acid output. We therefore conclude that maleic acid and succinic acid are the powerful stimulants of gastric acid output in fermented glucose and alcoholic beverages produced by fermentation, and that gastrin is not their mediator of action.  (+info)

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole. (7/1640)

BACKGROUND: Omeprazole has a greater intragastric pH elevating effect in Helicobacter pylori positive than negative subjects. Ammonia production by H pylori has been suggested as a probable mechanism. AIMS: To assess the effect of H pylori status on gastric acid secretion during omeprazole treatment, and to examine the possible role of ammonia neutralisation of intragastric acid in increased omeprazole efficacy in infected subjects. METHODS: Twenty H pylori positive and 12 H pylori negative healthy volunteers were examined before and six to eight weeks after commencing omeprazole 40 mg/day. On both occasions plasma gastrin and acid output were measured basally and in response to increasing doses of gastrin 17 (G-17). Gastric juice ammonium concentrations were also measured. RESULTS: Prior to omeprazole, measurements were similar in the H pylori positive and negative subjects. During omeprazole, median basal intragastric pH was higher in the H pylori positive (7.95) versus negative (3.75) subjects (p<0.002). During omeprazole basal, submaximal (180 pmol/kg/h G-17), and maximal acid outputs (800 pmol/kg/h G-17) were lower in H pylori positive subjects (0.0, 3.6, 6.0 mmol/h respectively) versus negative subjects (0.3, 14.2, 18.6 mmol/h) (p<0.03 for each). This effect was not explained by neutralisation by ammonia. CONCLUSION: The presence of H pylori infection leads to a more profound suppression of acid secretion during omeprazole treatment. The effect cannot be explained by neutralisation of intragastric acid by bacterial ammonia production and its precise mechanism has to be explained.  (+info)

Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels. (8/1640)

The anti-ulcer effects of nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester] were examined on water-immersion plus restraint stress-induced and aspirin-induced gastric ulcers in rats, compared with those of cimetidine. Nicorandil (3 and 10 mg/kg) given orally to rats dose-dependently inhibited the development of acid-related damage (water-immersion- and aspirin-induced gastric lesions) in the models. Cimetidine (50 mg/kg, p.o.) also had anti-ulcer effects in the same models. However, in the presence of glibenclamide (20 mg/kg, i.v.), an antagonist of K(ATP) channels, nicorandil did not inhibit the formation of gastric lesions. Nicorandil (10 mg/kg) given intraduodenally (i.d.), like cimetidine (50 mg/kg), significantly reduced the volume of the gastric content, total acidity and total acid output in the pylorus ligation model. Glibenclamide reversed the changes caused by i.d. nicorandil. I.v. infusion of nicorandil (20 microg/kg per min) significantly increased gastric mucosal blood flow, without affecting blood pressure and heart rate, but the increase in the blood flow was not observed after i.v. treatment with glibenclamide (20 mg/kg). These results indicate that nicorandil administered orally to rats produces the anti-ulcer effect by reducing the aggressive factors and by enhancing the defensive process in the mucosa through its K(ATP)-channel-opening property.  (+info)

*Leishmaniasis

The cutaneous form presents with skin ulcers, while the mucocutaneous form presents with ulcers of the skin, mouth, and nose, ... Expert review of anti-infective therapy. 11 (1): 79-98. doi:10.1586/eri.12.148. PMID 23428104. "Neglected Tropical Diseases". ... and in 1898 published the first accurate description of the causative agent, correctly described the parasite's relation to ... Mucocutaneous leishmaniasis causes both skin and mucosal ulcers with damage primarily of the nose and mouth. Visceral ...

*Discovery and development of proton pump inhibitors

Kaminski, James J.; Doweyko, Arthur M. (1997). "Antiulcer Agents. 6. Analysis of the in Vitro Biochemical and in Vivo Gastric ... and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are ... Nelson, Wendel L (2008). "Antihistamines and Related Antiallergic and Antiulcer Agents". In Lemke, Thomas L.; Williams, David A ... These new agents can in a reversible and competitive fashion inhibit the final step in the gastric acid secretion with respect ...

*Cinitapride

... (trade names Cintapro, Pemix) is a gastroprokinetic agent and antiulcer agent of the benzamide class which is ... non-ulcer dyspepsia and delayed gastric emptying. Benzamide Gastroprokinetic agent Robert M, Salvà M, Segarra R, et al. (July ...

*Aceglutamide

... an antiulcer agent, on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese ... and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor ... Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminum is used in the treatment of ulcers. ... Ito, M; Yokochi, E; Kobayashi, C; Suzuki, Y (1982). "Studies on defensive factors of experimental ulcers (2). Increasing action ...

*Hormone replacement therapy (female-to-male)

... an anti-ulcer agent that can cause gynecomastia in men because of this effect). Biaxin and other 'erythromycin type' ... Initial treatment is with increased cleansing (at least twice daily) with an anti-acne or oil reducing scrub. If this doesn't ...

*Troxipide

... is a systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting ... was achieved in patients with gastric ulcer and duodenal ulcer respectively. In patients with acute gastritis and acute gastric ... Hyeoyun (1989). "Peptic ulcers for the clinical effectiveness of Troxipide". Latest Med. 32 (2): 125-31. Dewan B, ... In patients with APDs like dyspepsia, gastritis, GERD and/or gastric ulcer, uncontrolled with acid inhibitors viz. proton pump ...

*Corneal ulcer

Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ... Refractory corneal ulcers are superficial ulcers that heal poorly and tend to recur. They are also known as indolent ulcers or ... Superficial ulcers involve a loss of part of the epithelium. Deep ulcers extend into or through the stroma and can result in ... Melting ulcers are a type of corneal ulcer involving progressive loss of stroma in a dissolving fashion. This is most commonly ...

*List of MeSH codes (D16)

... anti-ulcer agents MeSH D27.505.954.483.396 --- cathartics MeSH D27.505.954.483.508 --- cholagogues and choleretics MeSH D27.505 ... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ...

*Carbonic anhydrase inhibitor

Their clinical use has been established as anti-glaucoma agents, diuretics, antiepileptics, in the management of mountain ... sickness, gastric and duodenal ulcers, neurological disorders, or osteoporosis. Carbonic anhydrase inhibitors are primarily ...

*Cytoprotection

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more ... For example, a gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing ... Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing ... Cytoprotection is a process by which chemical compounds provide protection to cells against harmful agents. ...

*Metallopharmaceutical

Examples of metallopharmaceuticals include: bismuth subsalicylate - a mild anti-diarrheal also used in treating peptic ulcers ... 2005). Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley and Sons. ISBN 978 ... Most commonly metallopharmaceuticals are used as anticancer or antimicrobial agents. The efficiency of metallopharmaceuticals ... "Silver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta- ...

*Amyloid beta

Anti-aggregation agents such as apomorphine, or carbenoxolone. The latter has commonly been used as a treatment for peptic ... ulcers, but also displays neuroprotective properties, shown to improve cognitive functions such as verbal fluency and memory ... This is a common mechanism of action of anti-aggregation agents at large. Studies comparing synthetic to recombinant Aβ42 in ... Selective Aβ42 lowering agents (e. g. tarenflurbil). These modulate γ-secretase to reduce Aβ42 production in favor of other ( ...

*Tropomyosin

This discovery has led to the development of novel anti-tropomyosin compounds as potential anti-cancer agents. Tropomyosins ... have been implicated in the autoimmune disease ulcerative colitis, a disease of the colon that is characterised by ulcers or ... Smooth muscle may contract spontaneously or rhythmically and be induced by a number of physiochemical agents (hormones, drugs, ...

*Behçet's disease

Another Anti-TNF agent, etanercept, may be useful in people with mainly skin and mucosal symptoms. Interferon alpha-2a may also ... genital ulcers (including anal ulcers and spots in the genital region and swollen testicles or epididymitis in men) pathergy ... The anti-HSP60 and anti-HSP65 antibodies that target HSPs produced by Streptococci (including S. sanguinis and S. pyogenes) and ... They are a form of aphthous ulcers or non-scarring oral lesions. The oral lesions are similar to those found in inflammatory ...

*Idoxuridine

... is an anti-herpesvirus antiviral drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough ... Initially developed as an anticancer drug, idoxuridine became the first antiviral agent in 1962. Idoxuridine is mainly used ... Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while ...

*Resorcinol

It can be included as an anti-dandruff agent in shampoo or in sunscreen cosmetics.[citation needed] It has also been employed ... in the treatment of gastric ulcers in doses of 125 to 250 mg in pills, and is said to be analgesic and haemostatic in its ... It condenses with acids or acid chlorides, in the presence of dehydrating agents, to oxyketones, e.g., with zinc chloride and ... Resorcinol is also a common scaffold that is found in a class of anticancer agents, some of which (luminespib, ganetespib, KW- ...

*Migraine treatment

These effects are dose-dependent, and in many cases severe enough to pose the risk of ulcer perforation, upper gastrointestinal ... Furthermore, to date all migraine-provoking agents have had vasodilating properties. In patients where the pain has been ... Recommended initial treatment for those with mild to moderate symptoms are simple analgesics such as non-steroidal anti- ... Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek ...

*Cyanamide

The anti-ulcer drug cimetidine is generated using such reactivity. Related reactions exploit the bifunctionality of cyanamide ... Cyanamide, under the trade name Dormex, is a common agricultural rest-breaking agent applied in spring to stimulate uniform ... cyanamide behaves as a dehydration agent and thus can induce condensation reactions. Alcohols, thiols, and amines react ...

*Feline viral rhinotracheitis

... famciclovir is effective at treating this infection in cats without the side effects reported with other anti-viral agents. ... Conjunctivitis and corneal ulcers are treated with topical antibiotics for secondary bacterial infection. Lysine is commonly ... FHV-1 also has a predilection for corneal epithelium, resulting in corneal ulcers, often pinpoint or dendritic in shape. Other ...

*Benoxaprofen

285, p.1241 (30 October 1982) Somerville, K.W.; Hawkey, C.J.: Non-steroidal anti-inflammatory agents and the gastrointestinal ... Gastrointestinal side effects of benoxaprofen are bleeding, diarrhoea, abdominal pain, anorexia (symptom), mouth ulcers and ... Benoxaprofen had a considerably anti-inflammatory, analgesic and also anti-pyretic activity in those tests. In all six animals ... and adverse effects of non-steroidal anti-inflammatory agent benoxaprofen. Abstract Halsey, P.; Cardoe, N.: Benaxoprofen: side- ...

*Ebrotidine

... has anti-Helicobacter pylori activity via inhibition of the urease enzyme and the proteolytic and mucolytic ... Ebrotidine has been shown to be as effective as ranitidine for the treatment of gastric or duodenal ulcers or erosive reflux ... However, its activity is synergistic with a number of antibacterial agents. Ebrotidine counteracts the inhibitory effects of H ... oesophagitis, with significantly better ulcer healing rates (albeit inexplicably) in those who smoke. Patel SS, Wilde MI (Jun ...

*Alpinia nigra

A root extract is taken thrice daily for the treatment of gastric ulcers, and taken twice daily for the treatment of jaundice ... Its use as an antiinflammatory and analgesic agent has been supported by experiments in mice. The rhizome, cooked or raw, has ... Das BN, Biswas BK (2012). "Anti-inflammatory activity of the rhizome extract of Alpinia nigra". International Research Journal ...

*Bhasma

Perhaps this is to remove the excess amounts of agents used in shodhan or maran stage. Such agents may adversely affect the ... While mercury does have anti-microbial properties, and used to be widely used in Western medicine, its toxicity does not ... Neem is an antiseptic (Puranik and Dhamankar, 1964h). Zinc is antiseptic, astringent and has ulcer healing property (Block et ...

*Prostaglandin EP3 receptor

DG-041, a highly selective EP3 antagonist, has been proposed to warrant further study as anti-thrombosis agent. GR 63799X, MB- ... A partial list of these includes: Misoprostol, an EP3 and EP4 receptor agonist, is in clinical use to prevent ulcers, to induce ... It is considered to be an efficient and safe treatment for gastric and duodenal ulcers. ONO-9054 (Sepetoprost), a dual an EP3/ ... They are in development primarily as anti-thrombotics, i.e. drugs to treat pathological blood clotting in humans. EP3 is ...

*Anti-inflammatory

Antileukotrines are anti-inflammatory agents which function as leukotriene-related enzyme inhibitors (arachidonate 5- ... Agrawal N (June 1991). "Risk factors for gastrointestinal ulcers caused by nonsteroidal anti-inflammatory drugs (NSAIDs)". ... More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... Those following an anti-inflammatory diet will avoid refined oils and sugars, and show a preference for so-called anti- ...

*Edward Bliss

Anti-foreign sentiments increased and led to killing of foreigners and Chinese Christians. In fact, in the Shanxi province, ... Although it is common practice nowadays to view missionaries as agents of western imperialism, Bliss comes across well in his ... He treated conditions such as leg ulcers, scabies, erysipelas, consumption and malaria, but was unable to perform major surgery ... In this time period, anti-foreign feeling increased also, as the United States seemingly supported Japanese attempts to gain ...

*Arabic tea

Seasonal allergies can also be treated by drinking cups of tea made from rosemarynic acid, an anti-inflammatory agent found in ... and stomach ulcers. With high antioxidants and vitamins, peppermint helps enhance immunity and health. ...
1. Recently, some cases have been reported where intravenous use of omeprazole was followed by loss of vision. We followed up a cohort of close to 140,000 persons during periods of treatment and non-treatment with five anti-ulcer drugs.. 2. The relative risk of vascular disorders of the eye during use of omeprazole compared with non-use was 1.8 (95% CI 0.5-6.0). Use of other anti-ulcer drugs was associated with a similar risk of vascular disorders. The relative risk associated with current use of any anti-ulcer drug was 1.9 (95% CI 1.1-3.4). We did not find a single case of optic inflammatory disorder during treatment with any of the five anti-ulcer drugs.. 3. These results do not suggest a major increased risk for vascular or inflammatory disorders of the eye associated with use of omeprazole or other anti-ulcer drugs.. ...
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Chak, M. C. [翟敏莉]. (2004). A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-induced gastrointestinal effects. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_ ...
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Results A total of 364 patients (79.9% men; mean age, 67.1 years) comprised the full analysis set (esomeprazole, n=182; placebo, n=182). There was a statistically significant difference in the time to ulcer recurrence between esomeprazole and placebo (HR 0.09; 96.65% CI 0.02 to 0.41; p,0.001). The estimated ulcer-free rate at week 12 was 99.3% (esomeprazole) and 89.0% (placebo). The high estimated ulcer-free rate for esomeprazole was maintained through to week 48 (98.3% vs 81.2% of placebo-treated patients). No factors, other than female gender, reduced time to ulcer recurrence in addition to the effect of esomeprazole (p,0.001). Treatment with esomeprazole was generally well tolerated.. ...
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Omeprazole supplementation may aid in the bodies healthy function of the gastric region. Omeprazole aids the bodys natural functions in the reducing gastric acid and the general acidity of the stomach. Omeprazole may aid in the reduction of discomfort in animals with high acidity in the stomach. Diet plays a major role in the acidity levels in animals and why proper diet along with Omeprazole supplementation is the best approach to lessening discomfort related to acidity in animals. Our convenient once a day dosing of this supplement can be completed in tandem with your horses normal training schedule.. Administration: Make sure the horses mouth contains no feed before administration of Omeprazole paste. You may dose between ½ tube and 1 full tube every day. After delivering the dose, cap the tube and store the contents in a cool dry place for use the next day. You should observe the treated animal briefly after supplementation of the omeprazole paste to ensure that part of the dose is not ...
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Omeprazole is a medication used to treat GERD, ulcers, H. pylori infections, and other conditions. This eMedTV resource lists the various available omeprazole capsule strengths and offers tips and precautions for taking omeprazole caps.
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Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidines gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on the 8th day of dosing with either ranitidine bismuth citrate 800 mg twice daily or ranitidine 300 mg twice daily (double blind, randomised, parallel groups). Fasting and postprandial plasma gastrin and plasma pepsinogen I and II concentrations were measured, and a 13C-urea breath test was performed before and on the 8th day of dosing. The 13C-urea breath tests were positive in 21 patients before dosing and remained positive in nine of nine of the ranitidine dosed patients, whereas only two of 12 patients treated with ranitidine bismuth citrate remained positive. The expected rise in meal stimulated plasma gastrin with ranitidine was seen in the 12 patients who received ranitidine ...
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Ranitidine Bismuth Citrate (ra-NI-ti-deen BIZ-muth SIT-rate) Treats duodenal ulcers caused by infections from bacteria called H pylori. Given with an antibiotic called clarithromycin (Biaxin®).
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Like the delayed-release, enteric-coated, oral PPI formulations, IR-OME may prolong the elimination of drugs that are metabolized by oxidation in the liver, such as diazepam (Valium, Roche), (Coumadin candian, Bristol-Myers Squibb), and (Pfizer). Increased International Normalized Ratios (INRs) and prothrombin times have been reported in patients receiving concomitant warfarin and omeprazole therapy. These increases may lead to abnormal bleeding and possibly death. Therefore, patients taking canadian warfarin and omeprazole concomitantly should be monitored closely for INRs and pro-thrombin times.. In studies of once-daily omeprazole 40 mg and (e.g., Abbott) 500 mg every eight hours administered to healthy men, the steady-state plasma concentrations of omepra-zole were increased: the Cmax by 30%, the AUC0-24 by 89%, and the half-life by 34%).. INDICATIONS. As summarized in Table 1, IR-OME is indicated for the short-term treatment (four to eight weeks) of active duodenal ulcer, heartburn, and ...
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Objective - To compare the effects of oral administration of omeprazole and ranitidine on gastric squamous ulceration in Thoroughbreds in race training. Design - Modified crossover study. Animals - 60 Thoroughbreds in race training with gastric squamous mucosal ulceration. Procedure - Horses were randomly allocated into 3 groups. Group 1 received no treatment for 28 days followed by administration of omeprazole (4 mg/kg [1.8 mg/lb], PO, once daily) for 28 days; group 2 received omeprazole (4 mg/kg, PO, once daily) for 28 days followed by no treatment for 28 days; and group 3 received ranitidine (6.6 mg/kg [3.0 mg/lb], PO, q 8 h) for 28 days followed by administration of omeprazole (4 mg/kg, PO, once daily) for 28 days. Ulceration was assessed endoscopically at days 0, 28,42, and 56. Lesions were scored from 0 (no ulceration) to 3 (severe ulceration). Results - After the initial 28 days of treatment, the decrease in ulcer severity was significantly greater after omeprazole treatment than after ...
The safety and effectiveness of pantoprazole for short-term treatment (up to eight weeks) of erosive esophagitis (EE) associated with GERD have been established in pediatric patients 1 year through 16 years of age. Effectiveness for EE has not been demonstrated in patients less than 1 year of age. In addition, for patients less than 5 years of age, there is no appropriate dosage strength in an age-appropriate formulation available. Therefore, pantoprazole is indicated for the short-term treatment of EE associated with GERD for patients 5 years and older. The safety and effectiveness of pantoprazole for pediatric uses other than EE have not been established. 1 year through 16 years of age Use of pantoprazole in pediatric patients 1 year through 16 years of age for short-term treatment (up to eight weeks) of EE associated with GERD is supported by: a) extrapolation of results from adequate and well-controlled studies that supported the approval of pantoprazole for treatment of EE associated with ...
Lansoprazole is used short-term (4-8 weeks) to treat duodenal ulcer and erosive esophagitis. It may used long term to treat Zollinger-Ellison syndrome, a problem with too much acid being secreted. Lansoprazole capsules should be taken before eating. The capsules are delayed release meaning they work over time. The capsules should be swallowed whole and not crushed, opened or chewed. If you are taking theophylline, you may need your dosage checked when you start and stop lansoprazole to ensure your dose is effective. If you are taking sucralfate, it should be taken 30 minutes after taking lansoprazole. The most common side effects reported were diarrhea, nausea and abdominal pain. These occurred in fewer than 5% of patients. If your symptoms return after completing your course of therapy, talk to your physician for further evaluation.. ...
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There will be three cohorts in this Phase I, single-center, open-label, crossover study:. Cohort A (omeprazole): This is a open-label, non-randomized, one-sequence crossover study design, in which 20 healthy male subjects will be enrolled and administered a single oral dose of 40 mg omeprazole once daily for 8 days (Days 1-8) plus a single oral dose of 200 mg avanafil on Day 8. On Days 7 and 8, avanafil and/or omeprazole doses will be administered following an overnight fast of at least 10 hours.. All subjects will be confined at the Clinical Research Unit the day prior to the omeprazole administration on Day 7 and will remain confined for approximately 13 hours following the dosing on Day 8. Blood samples for determination of plasma omeprazole concentrations will be obtained from all subjects at 0 (10 minutes pre-dose), 20, 40 minutes and 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10 and 12 hours post-dose on Days 7 and 8. Pre-dose blood samples for determination of omeprazole will also be taken in the ...
Results: In the pyloric ligation model, the untreated control has shown 4.3 mEq/l of acidity, whereas the ranitidine-treated standard group shown 2 mEq/l and P. betle has shown 2.5 mEq/l acidity, respectively. In the stress-induced antiulcer model, the activity was more prominent, in the untreated control, there was 26 number of sores present, whereas the standard group showed only one number of ulcer sore, and in the P. betle treated group, there was four number of ulcer sores present. ...
This study sought to determi ne if high-dose omeprazole i nfusio n could improve the co ntrol of rebleedi ng i n patie nts with comorbid ill nesses a nd bleedi ng peptic ulcers. After achievi ng hemos
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Famotidine, a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and pathological hypersecretory conditions. Famotidine inhibits many of the isoenzymes of the hepatic CYP450 enzyme system. Other actions of Famotidine include an increase in gastric bacterial flora such as nitrate-reducing organisms ...
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TY - JOUR. T1 - Investigation of antiulcer activities of imidazo[1,2-α]pyridinyl-2-alkylaminobenzoxazoles and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles with electron-topological (ET) method. AU - Huang, Hsu Shan. AU - Chiou, Jeng Fong. AU - Chiu, Hui Fen. AU - Chen, Rong Fu. AU - Lai, Yu Liang. PY - 2002. Y1 - 2002. N2 - The study presents structure-activity considerations of a series of imidazo[1,2-α]pyridiny-2-alkylaminobenzoxazoles(I) and 5,6,7,8-tetahydroimidazo[1,2-α]pyridinylbenzoxazoles (II) investigated for anti-stress ulcer activity with the electron-topological method. A series of 39 compounds including 24 active and 15 weakly active was studied. It is shown that the fragment determined by the electron-topological method in an active molecule is responsible for anti-stress ulcer activity. Quantitative structure-activity relationships with electron topological approach of these compounds are discussed in terms of the statistical program STATGRAF-7.0.. AB - The study ...
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Your doctor might prescribe Nexium to treat various conditions, but the primary uses of the medication are treating GERD or acid reflux and stomach ulcers caused by anti-inflammatory medications. Esomeprazole also heals damaged stomach and esophageal linings, and long-acting Nexium can be swallowed in capsule form, ingested through a feeding tube or mixed with water or food by breaking apart the capsules and mixing the granules in soft foods like applesauce.[3]. Typical dosage is one capsule daily, and you shouldnt chew the granules so that you benefit from the time-released properties of the medication. Esomeprazole therapy might take several weeks before you experience significant relief. You should call your doctor if you experience side effects or your symptoms get worse, but dont stop taking the medicine if your condition improves until your doctor tells you to do so.. ...
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Illegally manufactured omeprazole products which many horse owners assume are legitimate generics of ULCERGARD have underperformed versus the FDA-approved product and have been found to vary widely in the amount of omeprazole they actually contain.3,4 In fact, when a product manufactured under the name of GastroMax3 was evaluated by UC Davis, it contained less than two-thirds of the omeprazole than its label claimed.5. When it comes to stability and efficacy, compounded omeprazole pastes simply dont measure up. In a 60-day study of five compounded pastes, formulations started as low as 63% of labeled concentration on day 0, and dipped to as low as 17% by day 60, and were ineffective in promoting the healing of stomach ulcers in horses.3 If its not stable in a lab environment, how could it possibly survive a barn setting? GASTROGARD concentrations remained stable throughout the study.. What this means is that if you are using an illegally manufactured product, you are likely not getting all of ...
Illegally manufactured omeprazole products which many horse owners assume are legitimate generics of ULCERGARD have underperformed versus the FDA-approved product and have been found to vary widely in the amount of omeprazole they actually contain.3,4 In fact, when a product manufactured under the name of GastroMax3 was evaluated by UC Davis, it contained less than two-thirds of the omeprazole than its label claimed.5. When it comes to stability and efficacy, compounded omeprazole pastes simply dont measure up. In a 60-day study of five compounded pastes, formulations started as low as 63% of labeled concentration on day 0, and dipped to as low as 17% by day 60, and were ineffective in promoting the healing of stomach ulcers in horses.3 If its not stable in a lab environment, how could it possibly survive a barn setting? GASTROGARD concentrations remained stable throughout the study.. What this means is that if you are using an illegally manufactured product, you are likely not getting all of ...
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The following criteria are the definitions for LETE in this study: 1. LETE in the On-Demand Setting: LETE occurs in the on-demand setting if 2 successive No Response ratings are recorded after 2 successive BeneFIX drug infusions in the absence of confounding factors. 2. LETE in the Prophylaxis Setting: LETE occurs in the prophylaxis setting if there is a spontaneous bleed within 48 hours (≤ 48 hours) after a regularly scheduled prophylactic dose of BeneFIX in the absence of confounding factors. 3. LETE (Low Recovery): LETE can also be lower than expected recovery of FIX in the opinion of the investigator following infusion of BeneFIX in the absence of confounding factors. Each reported occurrence of low recovery LETE was listed ...
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It is commonly known, accepted, and promoted in the equine nutrition and veterinary world that the capacity of feeds and forages to counteract changes in gastric pH (stomach acid) plays an important role in the prevention of gastric ulcers in horses. This ability to resist changes in pH is called buffering capacity. Lucerne hay has been shown in multiple studies to be effective in reducing the severity of ulcers in horses by providing superior buffering capacity compared to other forages ...
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Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Chiu on omeprazole diazepam interaction: No interaction with Valtrex and xanax (alprazolam).
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Members Mark Omeprazole is the name of the medication. It comes in the form of a tablet, and should be taken by mouth. It belongs to a class of medications called Proton Pump Inhibitor.
Equaline Omeprazole is the name of the medication. It comes in the form of a tablet, and should be taken by mouth. It belongs to a class of medications called Proton Pump Inhibitor.
China Omeprazole CAS 73590-58-6 Manufacturer, Omeprazole covalently binds to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.
Apr 21, · omeprazole and acid reflux; 3 users. I went to my doctor and was told to take omeprazole 20mg once a day. I took it for two weeks ad didnt feel any.
This is a temporary file and hence do not link it from a website, instead link the URL of this page if you wish to link the PDF file ...
Ang Omeprazole ay ginagamit panggamot sa acidic tiyan, Gastroesophageal kati sakit, Pagkain pipe nakapagpapagaling at sa iba pang kundisyon.
AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer. METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment. RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P,0.05). By per protocol analysis, the eradication rates were 80% and 83%, respectively, in patients treated for 1 or 2 wk (P,0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for ...
I am troubled by Laine and colleagues conclusion that there is little support for the use of H. pylori eradication therapy in patients with nonulcer dyspepsia (1). Since infected persons have a two- to sixfold increased risk for gastric cancer and certain types of lymphoma, isnt it reasonable to therefore offer curative therapy? Do we really have longitudinal studies of sufficient duration to know the actual long-term risks associated with continued H. pylori infection? In the same issue, the findings of Ohkusa and associates that precancerous gastric lesions improved after eradication of H. pylori(2) certainly support the premise of long-term benefit ...
Factors affecting Helicobacter pylori eradication rate with omeprazole (OME), clarithromycin (CL), and amoxicillin (AMO) have not been extensively studied. We have investigated the effect of age, sex,
BACKGROUND/AIMS A two-year, prospective, nationwide multicenter study was undertaken to evaluate the effect of Helicobacter pylori eradication on the development of reflux esophagitis (RE) and gastroesophageal reflux disease (GERD) symptoms in the Korean population. METHODS In total, 1,489 subjects without RE were enrolled at the outpatient clinics of 12 tertiary hospitals nationwide, and 452 subjects underwent follow-up (F/U) for 2 years to evaluate the development of RE and GERD symptoms. RESULTS RE was found in 33 subjects (7.3% of 452 subjects) and 14 subjects (7.3% of 192 subjects) during the first and second year of F/U, respectively. H. pylori status was not associated with the development of RE. RE was found in six (9.0%) of 67 H. pylori-negative patients, in 26 (11.2%) of 233 eradicated subjects and in eight (7.0%) of 114 noneradicated subjects (p=0.532). Multivariate analysis showed that age ≥60 years (odds ratio [OR], 7.11; 95% confidence interval [CI], 1.92 to 26.41), alcohol
Treatment with amoxicillin and omeprazole resulted in encouraging Helicobacter pylori eradication rates in pilot studies that included medium term follow up. These results were evaluated in a prospective, randomised and controlled study. Forty patients with active duodenal ulcer disease and H pylori colonisation of the gastric mucosa were randomly assigned to receive either omeprazole (20 mg twice daily) and amoxicillin suspension (500 mg four times daily) for two weeks (group I) or bismuth subsalicylate (600 mg three times daily), metronidazole (400 mg three times daily), tetracycline (500 mg three times daily), and ranitidine (300 mg in the evening) for two weeks (group II). Study medication was followed in both groups by a four week treatment course with 300 mg ranitidine up to the final examination. One patient from each group was lost to follow up. H pylori was eradicated in 78.9% of group I and 84.2% of group II (p = 1.00). All ulcers in patients on omeprazole plus amoxicillin healed but ...
Objective: To determine the prescribing patterns for proton pump inhibitors and to estimate the economic cost of their use in a group of patients affiliated with the Colombian Health System. Methods: This is a descriptive observational study. Data for analysis consisted of prescriptions dispensed between October 1st, 2010 and October 31st, 2010 and were collected from a systematic database of 4.2 million members. Socio-demographic variables were considered along with the defined daily dose, comedication, convenience of the indication for proton pump inhibitor use and costs. Results: In this study, 113,560 prescriptions were dispensed in 89 cities, mostly to women (57.6%) with a mean age of 54.4 ± 18.7 years; the drugs were omeprazole (n=111,294; 97.81%), esomeprazole (n=1,378; 1.2%), lansoprazole (n=524; 0.4%), pantoprazole and rabeprazole. The indication for 87,349 of the formulas (76.9%) was justified and statistically associated with the use of NSAIDs, antithrombotics, corticosteroids, ...
PROTON PUMP INHIBITORS PROTON PUMP INHIBITORS Are prodrugs. Active drug - Sulfenamide. MOA: Act by irreversibly inhibiting H+ K+ ATPase in gastric parietal cells. Steps of proton pump inhibition: Prodrugs reach parietal cells --| Sulfenamide (active moiety) formed --| Trapped inside parietal cell. Inhibits both basal acid output (nocturnal acid secretion) & meal-stimulated acid output (maximal acid output). Drugs: Omeprazole, pantoprazole, esomeprazole, lansoprazole & rabeprazole General drug properties: Weak bases & destroyed easily by gastric acid. Hence, protected as enteric coated tablets. Coating dissolves in intestinal juice (alkaline medium) & prodrugs are absorbed. Drug administration: Given orally in early morning, empty stomach (just before breakfast). Pantoprazole, esomeprazole & lansoprazole - Given as i.v. Short t1/2, yet inhibits acid secretion for |24 hours. Referred as

African Journal of Plant Science - scope of medicinal flora as effective anti ulcer agentsAfrican Journal of Plant Science - scope of medicinal flora as effective anti ulcer agents

Key words: Helicobacter pylori, Meckels Diverticulum ulcer, gastroesophageal reflux disease, peptic ulcer disease. ... we have given a detailed description of ulcer and its causative factors along with medicinal plants with antiulcer potency. ... The commercially available antiulcer drugs usually have various side effects. Due to these side effects, there is a need to ... less or no side effects and medicinal plants have always been the main source of new drugs for the treatment of gastric ulcer. ...
more infohttp://academicjournals.org/journal/AJPS/article-abstract/D2FB58440449

Gas x anti ulcer agent - What Does the Doctor Say?Gas x anti ulcer agent - What Does the Doctor Say?

Pasniciuc on gas x anti ulcer agent: It has no value for ulcer treatment. ... Ulcer (Definition) An ulcer is a discontinuity or a break in a body membrane that impedes the normal functioning of the organ ... Ulcers: H.pylori can cause gastritis and stomach ulcers so perhaps if you were symptomatic they want to decrease the acidity to ... Ulcers are further classified by their location. Ulcers are usually caused by infections, excessive acid production, stress, ...
more infohttps://www.healthtap.com/topics/gas-x-anti-ulcer-agent

Tie-up With Novartis AG Concerning New Anti-ulcer Agent CS-526 | UBE INDUSTRIES,LTD.Tie-up With Novartis AG Concerning New Anti-ulcer Agent CS-526 | UBE INDUSTRIES,LTD.

Daniel Vasella) concerning the new anti-ulcer agent, CS-526, an Acid Pump Antagonist (APA) that is currently under development ... Tie-up With Novartis AG Concerning New Anti-ulcer Agent CS-526. ... Basic Policy for Anti-Social Forces *Ube Group Compliance ... It has anti-Helicobacter pylori action, and according to the findings of non-clinical tests, it offers superior benefits in ...
more infohttps://www.ube-ind.co.jp/ube/en/news/2003/2003_11.html

Journal of Physiology and Pathophysiology - evaluation of the cytoprotective effects of anti-ulcer agents in acid-alcohol...Journal of Physiology and Pathophysiology - evaluation of the cytoprotective effects of anti-ulcer agents in acid-alcohol...

Group E: 20 mg/kg Omeprazole + Ulcer. Group F: 20 mg/kg ranitidine + ulcer. Group G: 100 mg/kg cimetidine + ulcer. At the end ... Ulcer alone; Group B: 20 mg/kg Rabeprazole + Ulcer; Group C: 20 mg/kg Rabeprazole + 20 mg/kg Ranitidine + Ulcer. Group D: ... Ulcers were induced via oral administration of a mixture acid alcohol (Ethanol and HCl). Group A: ... Key words: Ulcer, acid-alcohol, Rabeprazole, Ranitidine, Omeprazole, Ranitidine, Wistar rats. ...
more infohttps://academicjournals.org/journal/JPAP/article-full-text/CC0E84D61015

Antiulcer Agents - Nexium Is a Top Performer | PlanetDrugsDirect.comAntiulcer Agents - Nexium Is a Top Performer | PlanetDrugsDirect.com

Treating Zollinger-Ellison syndrome, ulcers caused by nonsteroidal anti-inflammatory drugs and gastroesophageal reflux disease ... Antiulcer Agents - Nexium Is a Top Performer. 4th May, 2014. Antiulcer therapies have made major advances in recent years with ... but the primary uses of the medication are treating GERD or acid reflux and stomach ulcers caused by anti-inflammatory ... Patients who took 40 mg and 20 mg of esomeprazole averaged ulcers in 1.5-percent of cases for 2,426 patients who took the ...
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Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents | Bentham...Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents | Bentham...

The Compounds 1e, 1j and 1d exhibited good gastro protective action as indicated by their low ulcer score. Overall, 1e was ... Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents. Author(s): ... Title:Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents ... Overall, 1e was obtained as lead compound with promising anti-inflammatory, antioxidant and antiulcer activities. ...
more infohttp://www.eurekaselect.com/97537

Hacip
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        Anti-Ulcer Agents,  Histamine H2 Antagonists,  ATC:A02BA03Hacip - Anti-Ulcer Agents, Histamine H2 Antagonists, ATC:A02BA03

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers; hypersecretory (increased acid secretion) ... For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). ... is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and ...
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Weimok
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        Anti-Ulcer Agents,  Histamine H2 Antagonists,  ATC:A02BA03Weimok - Anti-Ulcer Agents, Histamine H2 Antagonists, ATC:A02BA03

Famotidine is used to treat stomach and duodenal (upper small intestine) ulcers; hypersecretory (increased acid secretion) ... For the treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD). ... is used to treat gastrointestinal disorders such as gastric or duodenal ulcer, gastroesophageal reflux disease, and ...
more infohttp://pharmacycode.com/Weimok.html

Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study.   - ePrints@CFTRINovel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study. - [email protected]

Anti-Ulcer Agents; thiazolidinone derivatives Subjects:. 600 Technology , 01 Medical sciences , 15 Pharmacology. 500 Natural ... Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study. ... Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study. Letters in Drug Design ...
more infohttp://ir.cftri.com/10436/

Comparitive activities and mechanisms of action of three novel antiulcer agents  - CLOK - Central Lancashire Online KnowledgeComparitive activities and mechanisms of action of three novel antiulcer agents - CLOK - Central Lancashire Online Knowledge

The second phase of the study deals with the activity of the three compounds against gastric ulcers induced by acid ... Antiulcer agents, notably inhibitors of gastric acid secretion, have been the most successful category of drugs to be ... Chandranath, Swaminathan Irwin (2000) Comparitive activities and mechanisms of action of three novel antiulcer agents. Doctoral ... 136450 and TGFct are potent antisecretory and antiulcer agents which have great therapeutic importance. ...
more infohttp://clok.uclan.ac.uk/21028/

Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft - Full...Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft - Full...

Anti-Ulcer Agents. Gastrointestinal Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Gastric Ulcer Induced by Antiplatelet Agent Ulcer of the Gastrointestinal Tract Proton Pump Inhibitor Drug: Pantoprazole Phase ... Ulcer. Stomach Ulcer. Peptic Ulcer. Pathologic Processes. Duodenal Diseases. Intestinal Diseases. Gastrointestinal Diseases. ... Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft (DACAB ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03038009?term=Myocardial&

Peptic ulcer and non-steroidal anti-inflammatory agents. | GutPeptic ulcer and non-steroidal anti-inflammatory agents. | Gut

Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and ... was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of ... associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. ... There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) ...
more infohttp://gut.bmj.com/content/27/8/929

Pycnogenol Pine Bark | GreenMedInfo | Substance | Natural MedicinePycnogenol Pine Bark | GreenMedInfo | Substance | Natural Medicine

Anti-Ulcer Agents Research. [x] Remove Focus on Anti-Ulcer Agents. Filter by Study Type. Animal Study. ... Medicating with anti-histamines isnt a healthy option and can leave many feeling drowsy and fatigued. Luckily there are ... The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin.Aug ... natural remedies that are making waves for their powerful anti-histamine-like effects and abilities to suppress seasonal ...
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Lansoprazole - LiverTox - NCBI BookshelfLansoprazole - LiverTox - NCBI Bookshelf

... and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer ... Drug Class: Antiulcer Agents. Other Drugs in the Subclass, Proton Pump Inhibitors: Esomeprazole, Omeprazole, Pantoprazole, ... The typical dose in adults with peptic ulcer disease is 15 mg daily for 4 to 8 weeks and similar dose chronically for ... Higher doses are recommended for more severe cases of gastrointestinal reflux and peptic ulcer disease, and doses of up to 120 ...
more infohttps://www.ncbi.nlm.nih.gov/books/NBK548452/

The Effect of Stomach Acid on Foscarnet - Full Text View - ClinicalTrials.govThe Effect of Stomach Acid on Foscarnet - Full Text View - ClinicalTrials.gov

Anti-Ulcer Agents. Gastrointestinal Agents. Histamine H2 Antagonists. Histamine Antagonists. Histamine Agents. Neurotransmitter ... Anti-Infective Agents. Reverse Transcriptase Inhibitors. Nucleic Acid Synthesis Inhibitors. Enzyme Inhibitors. Anti-Retroviral ... Agents. Molecular Mechanisms of Pharmacological Action. Physiological Effects of Drugs. Antiviral Agents. ...
more infohttps://clinicaltrials.gov/show/NCT00000964?order=220

Efficacy and Safety of Dexlansoprazole Modified Release Formulation to Treat Heartburn - Full Text View - ClinicalTrials.govEfficacy and Safety of Dexlansoprazole Modified Release Formulation to Treat Heartburn - Full Text View - ClinicalTrials.gov

Anti-Ulcer Agents. Gastrointestinal Agents. Proton Pump Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological ... Chronic (,12 doses per month) use of nonsteroidal anti-inflammatory drugs (NSAIDs) or cyclo-oxygenase-2 (COX-2) inhibitors ... History of gastric, duodenal or esophageal surgery except simple oversew of an ulcer. ...
more infohttps://www.clinicaltrials.gov/ct/show/NCT00251745

A Drug-Drug Interaction Study of the Effect of Rabeprazole, Itraconazole or Fluconazole on the Pharmacokinetics of Vismodegib -...A Drug-Drug Interaction Study of the Effect of Rabeprazole, Itraconazole or Fluconazole on the Pharmacokinetics of Vismodegib -...

Anti-Ulcer Agents. Gastrointestinal Agents. Proton Pump Inhibitors. Cytochrome P-450 CYP2C9 Inhibitors. Cytochrome P-450 ... Antifungal Agents. Anti-Infective Agents. 14-alpha Demethylase Inhibitors. Cytochrome P-450 Enzyme Inhibitors. Enzyme ... Participation in any other investigational study drug or biological agent trial in which receipt of investigational study drug ... including gastric or duodenal ulcers), Zollinger-Ellison syndrome, Barretts esophagus, urological, neurological, or ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT01772290?term=vismodegib&rank=52

Appropriate acid suppression for the management of gastro-oesophageal reflux disease.  - PubMed - NCBIAppropriate acid suppression for the management of gastro-oesophageal reflux disease. - PubMed - NCBI

Anti-Ulcer Agents/administration & dosage. *Anti-Ulcer Agents/pharmacology. *Anti-Ulcer Agents/therapeutic use* ... Preliminary meta-analysis shows that the healing rate of erosive oesophagitis at 8 weeks by antisecretory agents is directly ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/1397746?dopt=Abstract

BPC 157 Special BOGO Order PageBPC 157 Special BOGO Order Page

BPC-157 is a naturally occurring anti-ulcer agent. Initially described in the early 1990 (Sikiric 1993), Pentadecapeptide BPC ... heal (stress-induced) ulcers and fistulas as they are increasingly common due to our stressful (this refers to stress as ... 157 has been identified as an endogenous antiulcer peptidergic agent - in other words: BPC-157 is small peptide (only 15 amino ... The problem, however, is that each of these studies simulated the oral administration of the agent by injecting the peptide ...
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View the content page [c]View the content page [c]

Kaminski, James J.; Doweyko, Arthur M. (1997). "Antiulcer Agents. 6. Analysis of the in Vitro Biochemical and in Vivo Gastric ... and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those that occur in cancer cells and are ... Nelson, Wendel L (2008). "Antihistamines and Related Antiallergic and Antiulcer Agents". In Lemke, Thomas L.; Williams, David A ... Direct comparison of pantoprazole sodium with other anti-secretory drugs showed that it was significantly more effective than H ...
more infohttp://www.let.rug.nl/~gosse/termpedia2/termpedia.php?language=dutch_general&density=7&link_color=000000&termpedia_system=perl_db&url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FDiscovery_and_development_of_proton_pump_inhibitors

Evaluation of antiulcerogenic activity of aqueous extract of Brassica oleracea var. capitata (cabbage) on Wistar rat gastric...Evaluation of antiulcerogenic activity of aqueous extract of Brassica oleracea var. capitata (cabbage) on Wistar rat gastric...

Headings: Anti-ulcer agents. Stomach ulcer. Brassica. Rats. RESUMO. CONTEXTO: O repolho (Brassica oleracea var. capitata) é uma ... capitata (AEB), investigating its healing action in model of ulcer induced by non-steroidal anti-inflammatory drugs. This ... The gastroprotective activity as evidenced by its significant inhibition in the formation of ulcers induced by chemical agent ... The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 2000;14:581-91. [ Links ]. ...
more infohttp://www.scielo.br/scielo.php?pid=S0004-28032011000400011&script=sci_arttext

Cayenne | GreenMedInfo | Substance | Natural Medicine | AlternativeCayenne | GreenMedInfo | Substance | Natural Medicine | Alternative

Pharmacological Actions : Anti-Ulcer Agents. Additional Keywords : Plant Extracts, Superiority of Natural Substances versus ... Capsicum frutescens and Curcuma longa had anti-oxidant and anti-glycation potentials. Aug 31, 2014. ... Capsicum annum L lyophilized fruit extract has a gastroprotective effect in experimentally-induced gastric ulcer in rats.Mar 31 ...
more infohttp://www.greenmedinfo.com/substance/cayenne

Design, synthesis, and urease inhibition studies of some 1,3,4-oxadiazoles and 1,2,4-triazoles derived from mandelic acid.Design, synthesis, and urease inhibition studies of some 1,3,4-oxadiazoles and 1,2,4-triazoles derived from mandelic acid.

Anti-Ulcer Agents. Drug Design. Enzyme Inhibitors / chemical synthesis, pharmacology. Humans. Inhibitory Concentration 50. ... 0/Anti-Ulcer Agents; 0/Enzyme Inhibitors; 0/Mandelic Acids; 0/Oxadiazoles; 0/Triazoles; 288-88-0/1,2,4-triazole; 90-64-2/ ... Previous Document: Interleukin-27, an anti-HIV-1 cytokine, inhibits replication of hepatitis C virus.. Next Document: Allergic ... These compounds may be subjected to further investigations for the development of antiulcer drugs.. ...
more infohttp://www.biomedsearch.com/nih/Design-synthesis-urease-inhibition-studies/20235688.html

Ranitidine hydrochloride solid | Sigma-AldrichRanitidine hydrochloride solid | Sigma-Aldrich

H2 histamine receptor antagonist; anti-ulcer agent. Packaging 1, 5 g in poly bottle ...
more infohttps://www.sigmaaldrich.com/catalog/product/SIGMA/R101?lang=en®ion=US

Maalox | definition of Maalox by Medical dictionaryMaalox | definition of Maalox by Medical dictionary

Therapeutic: antiulcer agents. Pharmacologic: antacids. Pregnancy Category: C. Indications. Useful in a variety of GI ... Neutralization of gastric acid with healing of ulcers and decrease in associated pain. ...
more infohttps://medical-dictionary.thefreedictionary.com/Maalox
  • It has anti-Helicobacter pylori action, and according to the findings of non-clinical tests, it offers superior benefits in comparison with existing drugs. (ube-ind.co.jp)
  • An ulcer is a lesion on a body surface (outer or inner) in which the epithelium and at least some of the underlying connective tissue has been lost specifically to necrosis (cell death) rather than just mechanical or chemical injury. (healthtap.com)
  • Cheney (13) verified that the patients who utilized the fresh cabbage juice obtained a healing action for gastric disorders, particularly for the peptic ulcer, presenting healing effects of the lesion. (scielo.br)
  • The proposed study was designed to establish the relative efficacy and mechanisms of action of three novel agents using both in vitro and in vivo models. (uclan.ac.uk)
  • This study enabled us to assess the extent to which antisecretory activity per se compared with other actions such as wound healing (TGFa) or anxiolytic activity (PD-136450) contribute to ulcer healing. (uclan.ac.uk)
  • Does 5month abdominal pain (controlled w/ anti emetic and lansoprazole) usually indicate something serious in 20yr old? (healthtap.com)
  • The results show that lansoprazole was the most potent antisecretory agent compared to other two drugs. (uclan.ac.uk)
  • In conclusion, the results of this study have indicated that lansoprazole, PD- 136450 and TGFct are potent antisecretory and antiulcer agents which have great therapeutic importance. (uclan.ac.uk)
  • Clinically apparent liver injury due to dexlansoprazole and lansoprazole, however, generally calls for prompt withdrawal of the agent. (nih.gov)
  • The results suggest that pycnogenol has an adjuvant effect on the healing of venous ulcers, similar to diosmin/hesperidin. (greenmedinfo.com)
  • Literature from anaesthetic screenings led attention to the potential antiviral compound pyridylthioacetamide which after further examination pointed the focus on an anti-secretory compound with unknown mechanisms of action called timoprazole . (rug.nl)
  • To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. (bmj.com)
  • Initially described in the early 1990 ( Sikiric 1993 ), Pentadecapeptide BPC 157 has been identified as an endogenous antiulcer peptidergic agent - in other words: BPC-157 is small peptide (only 15 amino acids) that occurs naturally in our gastric juice, where its main function seems to be to kickstart and accelerate the renewal and repair of the constantly assaulted lining of our intestinal tract. (ageforce.com)
  • Anxiolytic drug is otherwise known as anti-anxiety drugs, which are used to treat anxiety disorders, like depression, panic disorders, phobias and many personality disorders. (uclan.ac.uk)
  • and moreover, there are currently four such agents in the world list of top 25 best selling drugs. (uclan.ac.uk)
  • Ulcer healing is an active process of filling the mucosal defect with proliferating and migrating epithelial and tissue cells. (academicjournals.org)
  • The typical dose in adults with peptic ulcer disease is 15 mg daily for 4 to 8 weeks and similar dose chronically for maintenance therapy. (nih.gov)