Antibodies, Antineutrophil Cytoplasmic
Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.
Vasculitis
Myeloblastin
Wegener Granulomatosis
A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Neutrophils
Antibodies
Peroxidase
Microscopic Polyangiitis
Churg-Strauss Syndrome
Polyarteritis Nodosa
A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.
Systemic Vasculitis
Antibody Specificity
Retinal Vasculitis
Vasculitis, Central Nervous System
Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)
Vasculitis, Leukocytoclastic, Cutaneous
Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Autoantibodies
Glomerulonephritis
Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
Fluorescent Antibody Technique, Indirect
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Serine Endopeptidases
Skin Diseases, Vascular
Propylthiouracil
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Antithyroid Agents
Neutrophil Infiltration
Antibodies, Antinuclear
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Cathepsin G
Antibody Formation
Immunoglobulin G
Antibodies, Neutralizing
Autoantigens
Endocarditis, Subacute Bacterial
Colitis, Ulcerative
Purpura, Schoenlein-Henoch
A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.
Immunosuppressive Agents
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Prednisolone
Autoimmune Diseases
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Lactoferrin
An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.
Antibody Affinity
A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.
N-Formylmethionine Leucyl-Phenylalanine
Cyclophosphamide
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Rheumatoid Vasculitis
Plasma Exchange
Antibodies, Anti-Idiotypic
Leukocyte Elastase
Antibodies, Monoclonal, Murine-Derived
Binding Sites, Antibody
Hemoptysis
Chemotaxis, Leukocyte
Antigen-Antibody Complex
Methimazole
Neutrophil Activation
The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.
Lysosomal-Associated Membrane Protein 2
Biopsy
Cells, Cultured
Immunoglobulin M
Cryoglobulinemia
Lupus Erythematosus, Systemic
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Scleritis
Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
Immunoglobulin A
Graves Disease
A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
Antibodies, Neoplasm
Anti-Glomerular Basement Membrane Disease
An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.
Fixatives
Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.
Eosinophilia-Myalgia Syndrome
A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Cathepsins
Sensitivity and Specificity
Receptors, IgG
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
Levamisole
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Cross Reactions
Immunoglobulins, Intravenous
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.
Phagocytosis
Antigens, CD18
Proctocolectomy, Restorative
Drug Contamination
Azathioprine
Amino Acid Sequence
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Inflammatory Bowel Diseases
Immunologic Factors
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
Blood Proteins
Kidney
Mucocutaneous Lymph Node Syndrome
An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.
Crohn Disease
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
Cholangitis, Sclerosing
Superoxides
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
Glucocorticoids
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Granulocytes
Immunoglobulin Fab Fragments
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Tissue Fixation
Hepatitis, Autoimmune
Interleukin-8
Cytoplasm
Antimicrobial Cationic Peptides
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Chemotactic Factors
Respiratory Burst
A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.
Rabbits
Treatment Outcome
Antigen-Antibody Reactions
Renal Insufficiency
Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
Macrophage-1 Antigen
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Neutralization Tests
The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).
Leukocyte Count
Antibodies, Blocking
Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)
Remission Induction
Behcet Syndrome
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Antibodies, Bispecific
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
Cryoglobulins
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Severity of Illness Index
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Follow-Up Studies
Formaldehyde
A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Pancreatic Elastase
Drug Therapy, Combination
Immunohistochemistry
Kidney Glomerulus
Single-Chain Antibodies
Disease Models, Animal
Immune Sera
Lung
Blotting, Western
Inflammation
Immunoenzyme Techniques
Antigens, CD
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Pulmonary Alveoli
Leukotriene B4
Purpura
Giant Cell Arteritis
A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)
Antibodies, Heterophile
Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.
Antibodies, Catalytic
Epitope Mapping
Prospective Studies
Antibodies, Monoclonal, Humanized
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Leukocytes
Complement System Proteins
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Antibodies, Antiphospholipid
Antigens, Surface
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Takayasu Arteritis
A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.
Cell Movement
Arthus Reaction
B-Lymphocytes
Base Sequence
Cattle
Disease Progression
Complement C5a
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Plasmapheresis
Hybridomas
Chemokine CXCL1
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Immunization
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Receptors, Interleukin-8B
Cell Adhesion Molecules
Monocytes
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Cytokines
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Rheumatoid Factor
Electrophoresis, Polyacrylamide Gel
Skin
Tomography, X-Ray Computed
Cell Degranulation
NADPH Oxidase
A flavoprotein enzyme that catalyzes the univalent reduction of OXYGEN using NADPH as an electron donor to create SUPEROXIDE ANION. The enzyme is dependent on a variety of CYTOCHROMES. Defects in the production of superoxide ions by enzymes such as NADPH oxidase result in GRANULOMATOUS DISEASE, CHRONIC.
Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts. (1/99)
(+info)Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors. (2/99)
(+info)CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis. (3/99)
(+info)Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: a matched-pair cohort study. (4/99)
(+info)Small vessel vasculitis. (5/99)
(+info)Spontaneous resolution of delayed onset large subclavian artery pseudoaneurysm. (6/99)
A 70-year-old woman with a history of end-stage renal disease secondary to anti-neutrophil cytoplasmic autoantibody-associated vasculitis had been receiving hemodialysis for 5 years. The patient underwent attempted right internal jugular vein cannulation for temporary hemodialysis catheter placement. Pulsating mass developed in the neck and angiography revealed a subclavian artery pseudoaneurysm 4 days later. The pseudoaneurysm disappeared spontaneously during the interval between the diagnosis and the planned surgical procedure. Such delayed onset and spontaneous resolution of subclavian artery pseudoaneurysm is uncommon. Close observation may be optimal if delayed onset of pseudoaneurysm occurs after small needle puncture with cessation of antiplatelet/anticoagulant administration. (+info)Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (7/99)
(+info)Prediction of ESRD in pauci-immune necrotizing glomerulonephritis: quantitative histomorphometric assessment and serum creatinine. (8/99)
(+info)
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HDCN: Article by Woywodt et al.
<b>Circulating endothelial cells</b> as markers for <b>ANCA-associated
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Article: To find glomerulonephritis you have to look for it (full text) - January 2017 - NJM
Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody-associated...
TREATMENT-RELATED DAMAGE IN THE ANCA-ASSOCIATED VASCULITIDES: AN ANALYSIS OF THE EUROPEAN VASCULITIS STUDY GROUP THERAPEUTIC...
Simple, readily available clinical indices predict early and late mortality among patients with ANCA-associated vasculitis |...
ANCA-associated Vasculitis - MPA - Clinical Pain Advisor
Malignancy Risk in ANCA-Associated Vasculitis is Lower With Rituximab | Population Health Learning Network
SOP: antibody-associated autoimmune encephalitis | Neurological Research and Practice | Full Text
Overlapping central and peripheral nervous system syndromes in MOG antibody-associated disorders - Nuffield Department of...
Antibody-associated autoimmune neurological disease - Nuffield Department of Clinical Neurosciences
Glucocorticoids Key in Vasculitis Trial | Medpage Today
plasma exchange Archives - Renal Fellow Network
Anti-Plasminogen 抗体 (Biotin) (ab48364) | アブカム
Anti-Neutrophil antibody [NIMP-R14] (ab2557) References
VFMCRP and ChemoCentryx provide topline results from ACCOLADE trial of avacopan in C3 glomerulopathy including improved...
ANCA-associated vasculitis after scrub typhus<...
Low serum complement 3 level is associated with severe ANCA-associated vasculitis at diagnosis<...
ANCA-Associated Vasculitis, An Issue of Rheumatic Disease Clinics, Volume 36-3 - 1st Edition
Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in...
T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells? | Arthritis Research &...
Avacopan Noninferior to Prednisone for ANCA-Associated Vasculitis - MPR
Interventions for renal vasculitis in adults<...
Evaluation of antibodies against human HSP60 in patients with MPO-ANCA associated glomerulonephritis: a cohort study | Journal...
Comparison Study of Two Rituximab Regimens in the Remission of ANCA Associated Vasculitis - Full Text View - ClinicalTrials.gov
ANCA Vasculitis
Rituximab-Induced Hypogammaglobulinemia and Infections in AQP4 and MOG Antibody-Associated Diseases | PracticeUpdate
380 Comparisons of fatigue, anxiety and depression in systemic lupus erythematosus, systemic sclerosis and anti-neutrophil...
USE OF A COMPUTERISED SYSTEM TO FACILITATE EVALUATION OF ANTI-NEUTROPHIL CYTOPLASM (ANCA ASSOCIATED) VASCULITIS (AAV) AND OTHER...
After 40 Years, NIH-Supported Researchers Identify Possible New Treatment for Severe Vasculitis | WebWire
anti-Neutrophil Cytosolic Factor 4, 40kDa (NCF4) (N-Term) antibody</span...
Granulomatosis with polyangiitis
Determination of anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and ... Seo P, Stone JH (July 2004). "The antineutrophil cytoplasmic antibody-associated vasculitides". The American Journal of ... It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in GPA. ... Lally, L; Spiera, R (2015). "Current landscape of antineutrophil cytoplasmic antibody-associated vasculitis: classification, ...
Eosinophilic granulomatosis with polyangiitis
"Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a systematic review". JAMA. 298 (6): 655-69. doi: ... and antineutrophil cytoplasmic antibodies (ANCA) against neutrophil granulocytes. The American College of Rheumatology 1990 ... The third stage consists of vasculitis, which can eventually lead to cell death and can be life-threatening. This condition is ... It is a type of systemic necrotizing vasculitis. Effective treatment of EGPA requires suppression of the immune system with ...
Myeloperoxidase
Antibodies are also known as anti-neutrophil cytoplasmic antibodies (ANCAs), though ANCAs have also been detected in staining ... "Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis". Current Opinion in ... Antibodies against MPO have been implicated in various types of vasculitis, most prominently three clinically and ... Neutrophil myeloperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as mucus ...
Kawasaki disease
It can also be classed as an autoimmune form of vasculitis. It is not associated with anti-neutrophil cytoplasmic antibodies, ... Kawasaki disease is also considered to be a primary childhood vasculitis, a disorder associated with vasculitis that mainly ... "necrotizing vasculitis - definition of necrotizing vasculitis". Free Online Medical Dictionary, Thesaurus and Encyclopedia. ... Under this classification scheme for systemic vasculitis, Kawasaki disease is considered to be a necrotizing vasculitis (also ...
Vasculitic neuropathy
... and anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides such as granulomatosis with polyangiitis (GPA), ... Some examples of systemic vasculitic disease are: IgA vasculitis, Hypocomplementemic urticarial vasculitis, polyarteritis ... Some patients with systemic vasculitis will have their multi-organ disease spread to the peripheral nervous system; this is ... Graf, Jonathan; Imboden, John (January 2019). "Vasculitis and peripheral neuropathy:". Current Opinion in Rheumatology. 31 (1 ...
Vasculitis
Several of these vasculitides are associated with antineutrophil cytoplasmic antibodies. These are: Granulomatosis with ... which is vascular damage caused by nuclear debris from infiltrating neutrophils. It typically presents as palpable purpura. ... Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group? Ann Rheum Dis A Brooke W Eastham ... Other possible findings are elevated antineutrophil cytoplasmic antibody (ANCA) levels and hematuria. Other organ functional ...
Systemic vasculitis
Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a ... drug in relation to symptoms Palpable purpura Maculopapular rash Skin biopsy showing neutrophils around vessel IgA vasculitis ( ... A systematic review of antineutrophil cytoplasmic antibody (ANCA) positive vasculitis identified best treatments depending on ... but not most other vasculitides. Antineutrophil cytoplasmic antibody (ANCA) may highly suggest granulomatosis with polyangiitis ...
Anti-neutrophil cytoplasmic antibody
Stegeman, CA (Nov 2005). "Predictive value of antineutrophil cytoplasmic antibodies in small-vessel vasculitis: is the glass ... Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the ... 1 images of pANCA and cANCA fluorescence images of ANCA Anti-Neutrophil+Cytoplasmic+Antibody at the US National Library of ... Jennette, JC; Xiao, H; Falk, RJ (May 2006). "Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies". ...
P-ANCA
... , or MPO-ANCA, or perinuclear anti-neutrophil cytoplasmic antibodies, are antibodies that stain the material around the ... These include lactoferrin, elastase, and cathepsin G. When the condition is a vasculitis, the target is usually MPO. However, ... They are a special class of anti-neutrophil cytoplasmic antibodies. This pattern occurs because the vast majority of the ... Focal necrotizing and crescentic glomerulonephritis Rheumatoid arthritis C-ANCA Anti-neutrophil cytoplasmic antibody (ANCA) ...
Microscopic polyangiitis
October 2002). "Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis ... Then, the large number of antibodies make it more likely that they will bind a neutrophil. Once bound, the neutrophil ... An important diagnostic test is the presence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) with myeloperoxidase ... Most recently, two different groups of investigators have demonstrated that anti-MPO antibodies alone can cause necrotizing and ...
Proteinase 3
It is also the target of anti-neutrophil cytoplasmic antibodies (ANCAs) of the c-ANCA (cytoplasmic subtype) class, a type of ... Hilhorst M, van Paassen P, Tervaert JW (October 2015). "Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis". ... Ohlsson K, Linder C, Rosengren M (July 1990). "Monoclonal antibodies specific for neutrophil proteinase 4. Production and use ... PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil ...
Rapidly progressive glomerulonephritis
It is thought that antineutrophil cytoplasmic antibodies (ANCA) interact with antigens in the cytoplasm of neutrophils to cause ... Jennette, J. Charles; Nachman, Patrick H. (2017-10-06). "ANCA Glomerulonephritis and Vasculitis". Clinical Journal of the ... and type III and idiopathic RPGN are frequently associated with anti-neutrophil cytoplasmic antibodies (ANCA)-positive serum. ... The presence of anti-glomerular basement membrane (GBM) antibodies suggests type I RPGN; antinuclear antibodies (ANA) may ...
Eosinophilia
Zhang J, Zhang HY, Chen SZ, Huang JY (2016). "Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and ... eosinophilic vasculitis, and eosinophilic ulcer of the oral mucosa. Other examples of organ-restricted hepereosinophilia ... Afflicted tissues exhibit acute inflammation involving eosinophils, neutrophils, monocytes, lymphocytes, and plasma cells. The ... nonsteroidal anti-inflammatory drugs (NSAIDs), some antipsychotics such as risperidone, and certain antibiotics. Phenibut, an ...
Ronald J. Falk
"Anti-Neutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase in Patients with Systemic Vasculitis and ... In contrast, normal-density neutrophils were activated by MPO-ANCA and monoclonal anti-PR3 antibody. Normal-density neutrophil ... "Anti-Neutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase in Patients with Systemic Vasculitis and ... "Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro". Proceedings ...
User:Jfdwolff
Anti-neutrophil cytoplasmic antibody, Antithrombin, C1-inhibitor, Cancer procoagulant, Cholesterylester transfer protein, ... Cerebral vasculitis (got onto DYK), Cholesterol embolism (got onto DYK), Chronic granulomatous disease, Chronic kidney disease ... Diagnostic tests - Anti-citrullinated protein antibody, Blood culture, CA19-9, Cardiotocography, D-dimer, Endoscopic retrograde ... Nomenclature of monoclonal antibodies (talk), GA1 - review started 10/02/2011. *Azathioprine (talk), GA1 - review started 31/08 ...
Actin
The blot was reacted with anti-β-actin antibody (for other details of the blot see the reference ) The use of actin as an ... However the use of antibodies directed against different actin isoforms allows identifying not only the cytoplasmic beta in the ... Parks QM, Young RL, Poch KR, Malcolm KC, Vasil ML, Nick JA (Apr 2009). "Neutrophil enhancement of Pseudomonas aeruginosa ... vasculitis, and other conditions. Further, due to actin's close association with the apparatus of muscular contraction its ...
Actin
The blot was reacted with anti-β-actin antibody (for other details of the blot see the reference [204]) ... β-cytoplasmic, γ1-cytoplasmic, γ2-enteric smooth). Although the amino acid sequences and in vitro properties of the isoforms ... A dominant point mutation has also been discovered that causes neutrophil granulocyte dysfunction and recurring infections. It ... vasculitis, and other conditions.[207] Further, due to actin's close association with the apparatus of muscular contraction its ...
Granulomatosis with polyangiitis
Determination of anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and ... Seo P, Stone JH (July 2004). "The antineutrophil cytoplasmic antibody-associated vasculitides". The American Journal of ... It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in GPA.[ ... Lally, L; Spiera, R (2015). "Current landscape of antineutrophil cytoplasmic antibody-associated vasculitis: classification, ...
Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis | Renato Alberto Sinico | Springer
The book covers all aspects of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis, a term covering different auto- ... Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis. Editors: Sinico, Renato Alberto, Guillevin, Loïc (Eds.) ... covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group ... Founder of the French Vasculitis Study Group (FVSG) counting over 600 French physicians and with strong international contacts ...
Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Evidence | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...
Overview | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...
... with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis ... Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis. ... with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis in adults. ...
The Pathogenesis of Antineutrophil Cytoplasmic Antibody Renal Vasculitis | IntechOpen
Neutrophils play a critical role in the pathogenesis of ANCA vasculitis. Not only are neutrophils the primary effector cells in ... The Pathogenesis of Antineutrophil Cytoplasmic Antibody Renal Vasculitis, Updates in the Diagnosis and Treatment of Vasculitis ... The Pathogenesis of Antineutrophil Cytoplasmic Antibody Renal Vasculitis, Updates in the Diagnosis and Treatment of Vasculitis ... The Pathogenesis of Antineutrophil Cytoplasmic Antibody Renal Vasculitis. By Sharon Lee Ford, Stephen Roger Holdsworth and ...
https://www.thefreelibrary.com/Nasal+Septal+Perforation+in+Propylthiouracil-Induced+Anti-Neutrophil...-a0588340497
Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis.(Case Report) ... by Case Reports in Rheumatology; Health, general Antibodies Health aspects Viral antibodies ... Anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) generally occurs in middle-aged and older adults, and ... myeloperoxidase-anti-neutrophil cytoplasmic antibody; MTX: methotrexate; PR3-ANCA: proteinase 3-anti-neutrophil cytoplasmic ...
Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis - Full Text...
... anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody ... Prevention of Relapses in Proteinase 3 (PR3)-Anti-neutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis. The safety ... The investigators have found that patients with PR3-ANCA-associated vasculitis who remain cytoplasmic anti-neutrophil ... The investigators have found that patients with PR3-ANCA-associated vasculitis who remain C-ANCA positive after induction of ...
Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - ONA
Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis. *Serum HPV Antibody Levels May Be a Biomarker for ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...
Clinical trial for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Microscopic Polyangiitis , Wegeners ... ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis is characterised by small vessel vasculitis and presence of ... Low-dose Glucocorticoid Vasculitis Induction Study Brief description of study. Previous reports suggested conventional ... B cell depletion therapy by rituximab is a new strategy for remission induction in ANCA-associated vasculitis. The RAVE and ...
Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Renal and Urology News
Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... Short-Course Rituximab Produces Long-Term Remissions of ANCA Vasculitis. *Anti-Neutrophils Cytoplasmic Antibodies (ANCA) ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)
Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis. *Churg Strauss vasculitis (Churg Strauss granulomatosis ( ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
Renal function and ear, nose, throat involvement in anti-neutrophil cytoplasmic antibody-associated vasculitis: prospective...
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / diagnosis* * Anti-Neutrophil Cytoplasmic Antibody-Associated ... throat involvement in anti-neutrophil cytoplasmic antibody-associated vasculitis: prospective data from the European Vasculitis ... whether ENT involvement is associated with renal biopsy findings and renal function in patients with ANCA-associated vasculitis ...
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017
ANCA Vasculitis) Global Clinical Trials Review, H1, 2017 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA ... Vasculitis) Global Clinical Trials Review, H1, 2017 Summary GlobalDatas clinical - Market research report and industry ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017. Summary. ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017. Lowest ...
Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis
Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type | Annals...
Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type ... Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type ... Objective To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated ... vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO) antibodies) predicts treatment ...
Thiopurinemethyltransferase (TPMT) genotype and TPMT activity in patients with anti-neutrophil cytoplasmic antibody-associated...
Azathioprine is used in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) to maintain ... genotype and TPMT activity in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: relation to ... genotype and TPMT activity in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: relation to ...
Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies.
Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies ... Anti-neutrophil cytoplasmic antibodies (ANCA) are thought to be pathogenic in ANCA associated vasculitis (AAV) by stimulating ... Anti-neutrophil cytoplasmic antibodies (ANCA) are thought to be pathogenic in ANCA associated vasculitis (AAV) by stimulating ... Anti-neutrophil cytoplasmic antibodies (ANCA) are thought to be pathogenic in ANCA associated vasculitis (AAV) by stimulating ...
Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome | BMJ Case Reports
Hydralazine induces myeloperoxidase and proteinase 3 anti-neutrophil cytoplasmic antibody vasculitis and leads to pulmonary ... Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis: prevalence among patients with high titers of ... antielastase antibody and antiphospholipid antibody.15 17 Antihistone antibody is commonly seen with drug-induced vasculitis ... Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet 1993;342:651-2.doi: ...
Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis:...
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy* * Chi-Square Distribution * Cohort Studies ... Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: ... Predictors of treatment resistance and relapse have been identified in patients with antineutrophil cytoplasmic antibody (ANCA ... associated vasculitis in the Glomerular Disease Collaborative Network (GDCN) in the southeastern US. This study was undertaken ...
Antineutrophil cytoplasmic antibodies - their role in pathogenesis, diagnosis and treatment monitoring of ANCA-associated...
... associated vasculitis (AAV) constitutes a group of rare diseases characterized by necrotizing inflammation of small blood ... 2016): Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type. ... 2012): Classification of antineutrophil cytoplasmic autoantibody vasculitides: the role of antineutrophil cytoplasmic ... 2018): Anti-neutrophil cytoplasmic antibodies and their clinical significance. Clin Rheumatol 37: 875-884.. Savige J, Trevisin ...
Purchase: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, 2018
Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 -...
Your ticket for the: Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ...
Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and...
Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and ... and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We sought to define pharmacodynamic biomarkers of ... Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and ... For AAV, 8 of 11 biomarkers of the anti-inflammatory response to glucocorticoids were validated (P-value
Severe Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic...
Pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: the influence of ANCA subtype ... Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic Antibodies (PR3 ... Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associate vasculitis ... and anti-MPO 0U/ml. Other studies, which included anti-glomerular basement membrane antibodies, ANA, complement, ...
Clinical characteristics of patients with vasculitis positive for anti-neutrophil cytoplasmic antibody targeting both...
Although a few patients with vasculitis have both MPO- ... vasculitis positive for anti-neutrophil cytoplasmic antibody ... Anti-neutrophil cytoplasmic antibody (ANCA) may target proteinase 3 (PR3) or myeloperoxidase (MPO). ... Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type. Ann ... Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopathic systemic vasculitis. EC/BCR ...
Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 -...
Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ...
Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a...
Background Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical ... Anti-neutrophil cytoplasmic autoantibody pathogenicity revisited: pathogenic versus non-pathogenic anti-neutrophil cytoplasmic ... ANCA anti-neutrophil cytoplasmic antibody, BVAS Birmingham Vasculitis Activity Score, EGPA eosinophilic granulomatosis with ... Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a ...
Anti-neutrophil cytoplasmic antibody - Wikipedia
Stegeman, CA (Nov 2005). "Predictive value of antineutrophil cytoplasmic antibodies in small-vessel vasculitis: is the glass ... Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the ... 1 images of pANCA and cANCA fluorescence images of ANCA Anti-Neutrophil+Cytoplasmic+Antibody at the US National Library of ... Jennette, JC; Xiao, H; Falk, RJ (May 2006). "Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies". ...
Granulomatosis with polyangiitis - Wikipedia
Determination of anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and ... Seo P, Stone JH (July 2004). "The antineutrophil cytoplasmic antibody-associated vasculitides". The American Journal of ... It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in GPA. ... Lally, L; Spiera, R (2015). "Current landscape of antineutrophil cytoplasmic antibody-associated vasculitis: classification, ...
ANCASystemic vasculitidesTreating anti-neutrophil cytoplasmic antibodMyeloperoxidaseGranulomatosis with polyangiitisBirmingham Vasculitis Activity ScoreClinicalImmunofluorescenceDiagnosisPauci-immune glomerulonephritisCyclophosphamideVessel vasculitisGlomerulonephritisRelapseEthanol-fixed neutrophilsPrimary systemic necrotizingLeukocytoclastic vasculitisInvolvementSmall vesselsGlucocorticoidsInflammation2018Wegener's GranulomatosisPathogenesisPatientsRheumatologyDiseaseHeterogeneousBiopsyPerinuclearActivate neutrophilsGroup of autoantibodiesFrench Vasculitis Study GroupCutaneousMonoclonal antibodyGranulocytesCANCAPolyarteritisSevereNecrotizingPulmonaryArteriolesInduction
ANCA145
- This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). (springer.com)
- With a special interest in kidney failure, glomerulonephritis, vasculitis, lupus, cryoglobulinemia, rare autoimmune diseases, autoantibodies such as ANCA and anti-DNA, Prof. Sinico works with numerous international journals, and is the author of more than 160 scientific publications. (springer.com)
- Anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) generally occurs in middle-aged and older adults, and AAV patients manifest heterogeneous symptoms, such as fever, weight loss, myalgia, skin vasculitis, and sinonasal involvement. (thefreelibrary.com)
- Together with a destructive nasal lesion and positive MPO-ANCA, she was diagnosed with AAV, particularly PTU-induced AAV, based on the classification of vasculitis proposed by Watts et al. (thefreelibrary.com)
- Treatment of patients with PR3-ANCA-associated vasculitis consists of two phases: remission induction with highly effective, but also relatively toxic, drugs and, secondly, after remission is achieved, maintenance therapy with less toxic drugs. (clinicaltrials.gov)
- The investigators have found that patients with PR3-ANCA-associated vasculitis who remain cytoplasmic anti-neutrophil cytoplasmic autoantibody (C-ANCA) positive after induction of remission have an increased risk to experience relapse of disease. (clinicaltrials.gov)
- The most common pattern is the cytoplasmic pattern utilizing indirect immunofluoresence (c-ANCA) and Proteinase-3 as the target antigen by solid phase ELISA test. (oncologynurseadvisor.com)
- Previous reports suggested conventional immunosuppressants such as cyclophosphamide could not reduce glucocorticoid dose in remission induction in ANCA-associated vasculitis because of lower remission rate and higher relapse rate. (centerwatch.com)
- B cell depletion therapy by rituximab is a new strategy for remission induction in ANCA-associated vasculitis. (centerwatch.com)
- In addition, recent retrospective observational studies reported low-dose glucocorticoid plus rituximab led to re-induction in severe relapsing ANCA-associated vasculitis. (centerwatch.com)
- Thus, the investigators aim to investigate whether rituximab can reduce glucocorticoid dose in induction remission in ANCA-associated vasculitis (to show non-inferiority for efficacy between low-dose and high-dose glucocorticoid plus rituximab). (centerwatch.com)
- ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis is characterised by small vessel vasculitis and presence of autoantibodies, ANCA. (centerwatch.com)
- Current standard therapy in induction remission for ANCA-associated vasculitis is combination of high-dose glucocorticoid and IV-cyclophosphamide. (centerwatch.com)
- We investigated whether ENT involvement is associated with renal biopsy findings and renal function in patients with ANCA-associated vasculitis (AAV). (nih.gov)
- GlobalData's clinical trial report, "Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017 provides an overview of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) clinical trials scenario. (marketresearch.com)
- This report provides top line data relating to the clinical trials on Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis). (marketresearch.com)
- ANCA-associated vasculitis (AAV) commonly affects those of working age. (ovid.com)
- Objective To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO) antibodies) predicts treatment response. (bmj.com)
- Methods Treatment responses were assessed among patients enrolled in the Rituximab in ANCA-associated Vasculitis trial according to both AAV diagnosis (granulomatosis with polyangiitis (GPA)/microscopic polyangiitis (MPA)) and ANCA type (PR3-AAV/MPO-AAV). (bmj.com)
- Hydralazine-induced antinuclear cytoplasmic antibody (ANCA) vasculitis (AAV) is a rare phenomenon with pulmonary-renal syndrome with the most severe presentation. (bmj.com)
- Anti-neutrophil cytoplasmic antibodies (ANCA) are thought to be pathogenic in ANCA associated vasculitis (AAV) by stimulating polymorphonuclear leukocytes (PMNs) to degranulate and produce reactive oxygen species (ROS). (lu.se)
- PMNs from 5 AAV patients and 5 HCs were stimulated with 10 different IgGs, purified from PR3-ANCA positive patients, and ROS production, degranulation and neutrophil extracellular trap (NET) formation was measured. (lu.se)
- Predictors of treatment resistance and relapse have been identified in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis in the Glomerular Disease Collaborative Network (GDCN) in the southeastern US. (nih.gov)
- Fijołek J, Wiatr E. Antineutrophil cytoplasmic antibodies - their role in pathogenesis, diagnosis and treatment monitoring of ANCA-associated vasculitis. (termedia.pl)
- The antineutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitides (AAV) comprise a group of diseases characterized by necrotizing vasculitis of small vessels, with frequent involvement of the kidneys, lungs, lack or paucity of immune deposits in the vessel wall, and the presence - in the majority of cases - of autoantibodies to neutrophil constituents [1]. (termedia.pl)
- Then, myeolproxidase (MPO) and proteinase (PR3) were recognized as the major autoantigens accounting for the perinuclear (p-ANCA) and cytoplasmic (c-ANCA) patterns, respectively [4, 5]. (termedia.pl)
- ANCA in serum were originally detected by indirect immunofluorescence (IIF), and a positive IIF staining of only neutrophils without lymphocytes distinguishes ANCA from other types of autoantibodies. (termedia.pl)
- Glucocorticoids are standard of care for many chronic inflammatory conditions, including juvenile dermatomyositis (JDM) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (luriechildrens.org)
- Pulmonary involvement is common in ANCA-associated vasculitis (AAV), but rarely manifests as pulmonary emphysema (13% of cases). (archbronconeumol.org)
- We report the case of a 32-year-old man, smoker of 13 pack-years, with no exposure to other toxic substances, no family history, and no significant clinical history, who was diagnosed with anti-proteinase 3 (PR3) c-ANCA vasculitis and severe pulmonary emphysema. (archbronconeumol.org)
- Anti-neutrophil cytoplasmic antibody (ANCA) may target proteinase 3 (PR3) or myeloperoxidase (MPO). (springer.com)
- Although a few patients with vasculitis have both MPO- and PR3-ANCA, the details of their clinical characteristics are not known. (springer.com)
- The objective of this study was to analyze the characteristics of patients with dual MPO- and PR3-ANCA-positive vasculitis. (springer.com)
- The medical records of patients with ANCA and vasculitis confirmed by biopsy were reviewed. (springer.com)
- Of 85 patients with ANCA and vasculitis included in this study, 67 (78.8%) had MPO-ANCA, 10 (11.8%) had PR3-ANCA, and 8 (9.4%) had both MPO- and PR3-ANCA. (springer.com)
- Patients with dual-ANCA-positive vasculitis had considerably more kidney dysfunction than patients with MPO− PR3+ AAV. (springer.com)
- Watts RA, Mahr A, Mohammad AJ, Gatenby P, Basu N, Flores-Suárez LF (2015) Classification, epidemiology and clinical subgrouping of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. (springer.com)
- Cornec D, Cornec-Le Gall E, Fervenza FC, Specks U (2016) ANCA-associated vasculitis-clinical utility of using ANCA specificity to classify patients. (springer.com)
- Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical service. (springer.com)
- Systemic vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA) encompasses granulomatosis with polyangiitis (GPA, previously known as Wegener's granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA, previously known as Churg-Strauss syndrome). (springer.com)
- ANCA-associated systemic vasculitis (AAV) has a prevalence of 14-30 patients per 100,000 [ 1 ] and its most frequent severe manifestations include rapidly progressive glomerulonephritis leading to dialysis-requiring renal failure and alveolar capillaritis leading to pulmonary haemorrhage. (springer.com)
- The best defined and most studied subgroup of these diseases are the anti-neutrophil cytoplasmic antibody (ANCA)-related small vessel vasculitides (AASV), which are characterized by a pauci-immune microscopic vasculitis and focal, necrotizing glomerulonephritis ( 1 ). (asnjournals.org)
- Evidence suggests that tumor necrosis factor α (TNFα) plays a central role in the pathogenesis of AASV in which ANCA activates neutrophils, leading to endothelial and vascular damage. (asnjournals.org)
- Although NETs are essential in innate immunity, an excessive formation of NETs has adverse effects, e.g., induction of anti-neutrophil cytoplasmic antibody (ANCA), to the hosts. (biomedcentral.com)
- Since ANCA can induce NET formation in the primed neutrophils, a positive feedback loop can be formed between NETs and ANCA, which is called "ANCA-NETs vicious cycle. (biomedcentral.com)
- Although the illness improved after cessation of hydralazine, MPO-ANCA-associated vasculitis relapsed 16 months later. (biomedcentral.com)
- MPO-ANCA is the major pathogenic autoantibody in ANCA-associated vasculitis (AAV). (biomedcentral.com)
- Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain. (biomedcentral.com)
- Anti-neutrophils cytoplasmic antibodies (ANCA) are associated with a group of necrotizing small vessel vasculitides that usually have a paucity of vascular deposition of immunoglobulin and complement. (infectiousdiseaseadvisor.com)
- This distinguishes ANCA associated disease from disease caused by anti-glomerular membrane antibodies and disease caused by immune complexes, both of which have deposition of pathogenic immune complexes in vessel walls. (infectiousdiseaseadvisor.com)
- ANCA associated vasculitides include Wegener granulomatosis (WG), Microscopic polyangiitis (MPA) and its renal limited form, and Churg-Strauss syndrome (CSS). (infectiousdiseaseadvisor.com)
- ANCA are the most important laboratory tests used to confirm the diagnosis of this group of vasculitides. (infectiousdiseaseadvisor.com)
- ANCA are a heterogeneous group of autoantibodies, including antibodies with specificity for proteinase 3 (PR3) and myeloperoxidase (MPO). (infectiousdiseaseadvisor.com)
- A C-ANCA pattern identified by indirect immunofluorescence staining of neutrophils (diffuse staining of the cytoplasm sparing the nuclei) usually correlates with PR3-ANCA. (infectiousdiseaseadvisor.com)
- Although a P-ANCA (peri-nuclear staining) is usually associated with MPO-ANCA, antibodies specific for elastase, cathepsin G, and lactoferrin are also associated with P-ANCA. (infectiousdiseaseadvisor.com)
- C-ANCA plus with anti-PR3 are sensitive markers for WG. (infectiousdiseaseadvisor.com)
- P-ANCA with anti-MPO reactivity is less frequently found in WG and is associated with less organ involvement. (infectiousdiseaseadvisor.com)
- In particular, P-ANCA may be difficult to interpret, because anti-nuclear antibodies (ANA) may produce similar staining patterns on neutrophil nuclei. (thecardiologyadvisor.com)
- Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is one of the systemic vasculitides and characterised by necrotising vasculitis in small-sized vessels including arterioles, venules and capillaries and occasionally arteries. (researchsquare.com)
- Diagnosis of vasculitis is based on the presence of histologic features and serological testing for antineutrophil cytoplasmic antibodies (ANCA). (eurekaselect.com)
- In patients with vasculitis, two types of ANCA have been identified: ANCA directed against the neutrophil serine protease proteinase-3 (PR3) which results in a cytoplasmic immunofluorescence pattern (c-ANCA) and ANCA directed against the neutrophil enzyme myeloperoxidase (MPO), which results in a perinuclear immunofluorescence pattern (p-ANCA). (eurekaselect.com)
- Question is if the presence of ANCA is the consequence of abnormal neutrophil adhesion, activation, and apoptosis. (eurekaselect.com)
- In the latter case it has to be postulated that ANCA autoantigens are expressed on the cell surface of viable, or activated, or early-apoptotic neutrophils. (eurekaselect.com)
- Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) are multisystem diseases of small blood vessels, collectively known as the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). (ox.ac.uk)
- Background: So far, there has been no tool to estimate activity at diagnosis and predict all-cause mortality in patients with ANCA-associated vasculitis (AAV). (elsevier.com)
- The purpose of this research study is to see if Eculizumab (Soliris®) can safely be used in addition to conventional therapy in patients with active ANCA (Antineutrophil Cytoplasmic Autoantibodies ) vasculitis and lead to a more rapid decrease in disease activity. (clinicaltrials.gov)
- ANCA vasculitis is an inflammation of the small vessels whereby ANCA antibodies inappropriately activate one's own white blood cells (neutrophils) and cause damage to the small blood vessels. (clinicaltrials.gov)
- Recent laboratory studies have identified that an important pathway of inflammation called the 'complement pathway' may play an important role in how Antineutrophil Cytoplasmic Autoantibodies (ANCA) cause damage to the blood vessels. (clinicaltrials.gov)
- In a mouse model of ANCA vasculitis, it has been shown that blocking C5 activation can block the development of vasculitis or greatly reduce its severity. (clinicaltrials.gov)
- The researchers in this study would like to see if taking eculizumab, in addition to the drugs usually used to treat ANCA vasculitis, would be beneficial in treating ANCA vasculitis. (clinicaltrials.gov)
- Currently, the conventional treatment of ANCA vasculitis consists of corticosteroids and cyclophosphamide. (clinicaltrials.gov)
- The study drug, eculizumab, is Food and Drug Administration (FDA) approved for indications other than ANCA vasculitis. (clinicaltrials.gov)
- It is an investigational drug and it is NOT FDA-approved for the treatment of ANCA vasculitis. (clinicaltrials.gov)
- Standard of care for ANCA vasculitis treatment- depends on severity of disease and individual characteristics and medical history of each patient so this won't be described here. (clinicaltrials.gov)
- For monitoring disease activity, we advise physicians to order ANCA / Cytoplasmic Neutrophil Antibodies, Serum or MPO / Myeloperoxidase Antibodies, IgG, Serum. (testcatalog.org)
- Antineutrophil cytoplasmic antibodies (ANCA) occur in patients with autoimmune vasculitis including Wegener granulomatosis (WG), microscopic polyangiitis (MPA), or organ-limited variants thereof such as pauci-immune necrotizing glomerulonephritis. (testcatalog.org)
- 1) ANCA react with enzymes in the cytoplasmic granules of human neutrophils including proteinase 3 (PR3), myeloperoxidase (MPO), elastase, and cathepsin G. (testcatalog.org)
- Positive results for proteinase 3 (PR3) antineutrophil cytoplasmic antibodies (ANCA) and cANCA or pANCA are consistent with the diagnosis of Wegener granulomatosis (WG), either systemic WG with respiratory and renal involvement or limited WG with more restricted end-organ involvement. (testcatalog.org)
- Positive results for MPO ANCA and pANCA are consistent with the diagnosis of autoimmune vasculitis including microscopic polyangiitis (MPA) or pauci-immune necrotizing glomerulonephritis. (testcatalog.org)
- The discovery that antineutrophil cytoplasmic antibodies (ANCA) are strongly associated with vasculitic disorders and their subsequent characterisation has led to improved understanding of the pathogenic mechanisms underlying vasculitis. (bmj.com)
- Antineutrophil cytoplasmic antibodies (ANCA) are circulating autoantibodies which identify a specific subpopulation of patients with systemic vasculitis. (bmj.com)
- These autoantibodies were originally detected by immunofluorescence and two distinct patterns were described: cytoplasmic or c-ANCA which are directed against proteinase-3, and perinuclear (p-ANCA) which is usually directed against myeloperoxidase although other antigenic targets, the nature and relevance of which will be discussed below, have been described. (bmj.com)
- In reality, therefore "ANCA" now refer to an increasing number of autoantibodies directed against targets within neutrophils and are associated, in general with clinically different, although often overlapping, diseases. (bmj.com)
- 2-5 Although up to 5% of patients with "classical" Wegener's granulomatosis are found to have p-ANCA, this antibody is usually associated with a number of other vasculitic syndromes including idiopathic necrotising and crescentic glomerulonephritis, Churg-Strauss syndrome, microscopic polyangiitis, and a growing list of other inflammatory disorders. (bmj.com)
- 1 8 There has been some recent interest in looking for ANCA in bronchoalveolar fluid of patients suspected of having pulmonary vasculitis in whom searches for serum ANCA antibodies have been fruitless. (bmj.com)
- Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis commonly involves kidney, lung, upper respiratory tract, skin, gastrointestinal and occasionally peripheral nervous system. (mec.pt)
- We present a case of a 21-year-old female with chronic kidney disease secondary to myeloperoxidase ANCA associated vasculitis, diagnosed at age 19. (mec.pt)
- 200 RU/mL), reinforcing our diagnostic hypothesis of central nervous system (CNS) recurrence of ANCA vasculitis. (mec.pt)
- This is a case of ANCA associated vasculitis that presented with kidney and lung but no CNS involvement and recurred with primarily cerebral disease. (mec.pt)
- Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a collection of relatively rare autoimmune diseases of unknown cause, characterized by inflammatory cell infiltration causing necrosis of small vessels, with few or no immune deposits 1-3 . (mec.pt)
- The introduction of immunosuppressive therapy for ANCA-associated vasculitis (AAV) has greatly improved outcomes, though patients now accumulate damage from vasculitis activity and adverse effects of treatment. (cdc.gov)
- Genetic variants in ANCA-associated vasculitis: a meta-analysis. (cdc.gov)
- Diagnosis and management of ANCA associated vasculitis. (radiopaedia.org)
- 2. Kamesh L, Harper L, Savage CO. ANCA-positive vasculitis. (radiopaedia.org)
- Management of ANCA-associated vasculitis: Current trends and future prospects. (radiopaedia.org)
- It was well known that propylthiouracil (PTU) could induce ANCA-associated vasculitis (AAV) and clinical evident vasculitis could resolve after cessation of PTU with or without immunosuppressive therapy. (scienceopen.com)
- Objective To identify biomarkers that distinguish between active antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and remission in a manner superior or complementary to established markers of systemic inflammation. (elsevier.com)
- Methods Markers of vascular injury and angiogenesis were measured before and after treatment in a large clinical trial in AAV: 163 subjects enrolled in the Rituximab in ANCA-Associated Vasculitis trial were screened for the present study. (elsevier.com)
- IgM ANCA in healthy individuals and in patients with ANCA-associated vasculitis. (nih.gov)
- IgM anti-neutrophil cytoplasmic antibodies (ANCA) have been reported in patients with ANCA-associated vasculitis (AAV). (nih.gov)
- The first aim of the study was to determine whether IgM ANCA was present in healthy individuals and in patients with ANCA-associated vasculitis. (nih.gov)
- Sera from healthy individuals and patients with AAV were tested for IgM ANCA by immunofluorescence on fixed neutrophils, immunoprecipitation, Western blot and ELISA. (nih.gov)
- We report the presence of low-level specific IgM ANCA in the sera of healthy individuals and in patients with ANCA-associated vasculitis. (nih.gov)
- Anti-neutrophil cytoplasmic antibody (ANCA) in necrotising vasculitides with renal involvement. (bvsalud.org)
- Anti-neutrophil cytoplasmic antibody (ANCA) was detected in sera of 20 out of 32 patients with necrotising vasculitides involving the kidneys and other organs. (bvsalud.org)
- A 77-year-old man developed severe renal insufficiency due to proteinase 3 anti-neutrophil cytoplasmic antibody PR3-ANCA-associated vasculitis, and was started on hemodialysis HD. (duhnnae.com)
- Objectives: ANCA-associated vasculitis (AAV) can affect all age groups. (elsevier.com)
- We adjusted associations for the type of AAV and the type of ANCA (anti-MPO, anti-PR3 or negative). (elsevier.com)
- Forty (31.3%) had associated systemic diseases, which included 10 with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and 8 with rheumatoid arthritis (RA). (docwirenews.com)
- Patients with ANCA-associated vasculitis had a tendency to develop scleritis first and had significantly worse visual prognoses compared to those with RA. (docwirenews.com)
- Approximately 30% of the patients with scleritis and episcleritis had complications involving systemic diseases, including ten patients with ANCA-associated vasculitis and 8 with RA. (docwirenews.com)
- ANCA-associated vasculitis was more often diagnosed after scleritis and patients suffered poorer visual prognoses than those with RA. (docwirenews.com)
- The study hypothesis is that a 'reinforced' pneumococcal combined vaccine strategy in patients with ANCA-associated vasculitides treated with rituximab will induce a better immune response than the current standard regimen, with an acceptable safety profile. (clinicaltrials.gov)
- Treatment of Relapses in ANCA-Associated Vasculitis. (nih.gov)
- Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterised by the autoinflammation and necrosis of blood vessel walls. (biomedcentral.com)
- Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) represents a group of systemic autoimmune diseases including Wegener's granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome and renal limited vasculitis [ 1 ]. (biomedcentral.com)
- Some patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) also have positivity of rheumatoid factor (RF). (biomedcentral.com)
- In this study, we used targeted serum proteomics to identify circulating biomarkers for prediction of disease activity and organ involvement in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (biomedcentral.com)
- ANCA have been shown to play a potential role in the pathogenesis of vasculitis [ 2 ]. (biomedcentral.com)
- To evaluate the safety and efficacy of belimumab as adjunctive therapy to maintain remission in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (ox.ac.uk)
- The primary end point was time to first protocol-specified event (PSE), with first PSE defined as a Birmingham Vasculitis Activity Score (BVAS) of ≥6, presence of ≥1 major BVAS item, or receipt of prohibited medications for any reason, resulting in treatment failure (adjusted for ANCA type [proteinase 3 (PR3) or myeloperoxidase (MPO)], disease stage at induction, and induction regimen). (ox.ac.uk)
- Vasculitis relapse in the placebo group (n = 8) occurred independent of the induction regimen, disease stage, or ANCA type. (ox.ac.uk)
- All vasculitis relapses in the belimumab group (n = 6) occurred in patients who had PR3-ANCA-associated vasculitis with cyclophosphamide-induced disease remission. (ox.ac.uk)
- Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). (beds.ac.uk)
- Some reports have demonstrated RPGN with the sequential appearance of ANCA then anti-GBM antibodies, suggesting that ANCA may induce the development of anti-GBM antibodies. (beds.ac.uk)
- The diagnosis was RPGN associated with anti-GBM nephritis and ANCA-associated vasculitis. (beds.ac.uk)
- This report shows that preceding NTM infection may have induced ANCA and anti-GBM antibodies and caused the development of RPGN. (beds.ac.uk)
- ANCA-associated vasculitis (AAV) is classified into granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), and is defined as small-vessel vasculitides. (beds.ac.uk)
- This is a case study of RPGN that was preceded by NTM infection, followed by an ANCA response and then later by an anti-GBM antibody response. (beds.ac.uk)
- Both ANCA and anti-GBM antibodies are autoantibodies that could induce RPGN. (beds.ac.uk)
- It is possible, therefore, that NTM-induced ANCA, followed by the subsequent production of anti-GBM antibodies can lead to RPGN. (beds.ac.uk)
- Small vessel vasculitis comprises antineutrophil cytoplasmic autoantibodies (ANCA) associated vasculitis, Churg-Strauss syndrome and microscopic polyangitis, they usually occur in the small blood vessels innervating organs such as kidneys and lungs. (researchandmarkets.com)
- Biologics are leading the drug class segment due to better clinical outcomes in patients suffering with ANCA associated vasculitis and promising biological drugs in the pipeline with enhanced drug safety and efficacy. (researchandmarkets.com)
- Small vessel vasculitis is anticipated to showcase impressive growth in the near future due to rising prevalence of ANCA associated small vessel vasculitis in the Mongolian population and rise in the occurrence of leukocytoclastic vasculitis with palpable purpura due to post viral syndromes and drugs. (researchandmarkets.com)
- They are detected as a blood test in a number of autoimmune disorders, but are particularly associated with systemic vasculitis, so called ANCA-associated vasculitides (AAV). (wikipedia.org)
- Immunofluorescence (IF) on ethanol-fixed neutrophils is used to detect ANCA, although formalin-fixed neutrophils may be used to help differentiate ANCA patterns. (wikipedia.org)
- cytoplasmic ANCA (c-ANCA), C-ANCA (atypical), perinuclear ANCA (p-ANCA) and atypical ANCA (a-ANCA), also known as x-ANCA. (wikipedia.org)
- c-ANCA shows cytoplasmic granular fluorescence with central interlobular accentuation. (wikipedia.org)
- C-ANCA (atypical) shows cytoplasmic staining that is usually uniform and has no interlobular accentuation. (wikipedia.org)
- p-ANCA has three subtypes, classical p-ANCA, p-ANCA without nuclear extension and granulocyte specific-antinuclear antibody (GS-ANA). (wikipedia.org)
- a-ANCA often shows combinations of both cytoplasmic and perinuclear staining. (wikipedia.org)
- Classical p-ANCA occurs with antibodies directed to MPO. (wikipedia.org)
- p-ANCA without nuclear extension occurs with antibodies to BPI, cathepsin G, elastase, lactoferrin and lysozyme. (wikipedia.org)
- Atypical ANCA are thought to be antigens similar to that of the p-ANCAs, however may occur due to differences in neutrophil processing. (wikipedia.org)
- This theory solves the paradox of how it could be possible for antibodies to be raised against the intracellular antigenic targets of ANCA. (wikipedia.org)
Systemic vasculitides5
- Loïc Guillevin is a specialist in internal medicine, involved for many years in the management and care of patients affected by systemic vasculitides, like eosinophilic granulomatosis with polyangitis syndrome, but also granulomatous polyangitis granulomatosis, classical or hepatitis B virus (HBV)-related polyarteritis nodosa, microscopic polyangiitis or mixed essential cryoglobulinemia. (springer.com)
- DCVAS Diagnostic and classification of the systemic vasculitides. (eurekaselect.com)
- This paper will review clinical aspects of pulmonary involvement in the systemic vasculitides and explores the impact which the discovery of auto-antibodies in these disorders has had on our understanding of their pathogenesis. (bmj.com)
- 5. Pesci A, Manganelli P. Respiratory system involvement in antineutrophil cytoplasmic-associated systemic vasculitides: clinical, pathological, radiological and therapeutic considerations. (radiopaedia.org)
- When using the influential classification known as the "Chapel Hill Consensus Conference", the terms "systemic vasculitis" or "primary systemic vasculitides" are commonly used. (wikipedia.org)
Treating anti-neutrophil cytoplasmic antibod1
- Evidence-based recommendations on rituximab (MabThera) with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis in adults. (nice.org.uk)
Myeloperoxidase6
- Falk RJ, Jennette JC (1998) Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. (springer.com)
- Franssen C, Gans R, Kallenberg C, Hageluken C, Hoorntje S (1998) Disease spectrum of patients with antineutrophil cytoplasmic autoantibodies of defined specificity: distinct differences between patients with anti-proteinase 3 and anti-myeloperoxidase autoantibodies. (springer.com)
- Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), which are extruded from activated neutrophils. (biomedcentral.com)
- If myeloperoxidase antibody or proteinase 3 antibody is ≥0.4 U, then cytoplasmic neutrophilic antibodies will be performed at an additional charge. (testcatalog.org)
- 1 8 Proteinase-3 and myeloperoxidase usually reside within azurophil granules in the neutrophil and are normally involved in host defence against invading organisms. (bmj.com)
- Myeloperoxidase (MPO) is a peroxidase enzyme most abundantly present in neutrophil granulocytes (a subtype of white blood cells). (news-medical.net)
Granulomatosis with polyangiitis5
- Witko-Sarsat, V. Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation. (eurekaselect.com)
- The serotype should be accompanied by the clinicopathologic variant if this can be determined: microscopic polyangiitis, granulomatosis with polyangiitis (Wegener), eosinophilic granulomatosis with polyangiitis (Churg Strauss), or renallimited vasculitis. (mec.pt)
- AAV includes eosinophilic granulomatosis with polyangiitis (EGPA), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and renal-limited vasculitis (RV). (biomedcentral.com)
- ANCAs are associated with small vessel vasculitides including granulomatosis with polyangiitis, microscopic polyangiitis, primary pauci-immune necrotizing crescentic glomerulonephritis (a type of renal-limited microscopic polyangiitis), eosinophilic granulomatosis with polyangiitis and drug induced vasculitides. (wikipedia.org)
- Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), is an extremely rare long-term systemic disorder that involves the formation of granulomas and inflammation of blood vessels (vasculitis). (wikipedia.org)
Birmingham Vasculitis Activity Score3
- Severe AAV was defined as Birmingham Vasculitis Activity Score (BVAS) ≥ 16. (elsevier.com)
- The primary outcome measure was the difference in marker level between screening and month 6 among patients whose disease was in remission (Birmingham Vasculitis Activity Score for Wegener's granulomatosis [BVAS/WG] score of 0) at month 6. (elsevier.com)
- The Birmingham Vasculitis Activity Score (BVAS) was higher ( P = 0.026) in the RF-positive subset than in the RF-negative subset. (biomedcentral.com)
Clinical6
- Vessels of any size can be involved which explains the diverse spectrum of clinical diseases attributed to vasculitis. (intechopen.com)
- 4 ] A clinical report of 'Vasculitis' originated from the mid-nineteenth century[ 5 ] and clinical descriptions of these diseases were published in the 1930s,[ 6 ] however it was not until the 1950s that Wegener's Granulomatosis, Churg Strauss Syndrome and Microscopic polyangiitis were identified as unique clinical entities. (intechopen.com)
- Persistent hematuria in patients with antineutrophil cytoplasmic antibody-associated vasculitis during clinical remission: chronic glomerular lesion or low-grade active renal vasculitis? (biomedcentral.com)
- Wiik, A. Antineutrophil cytoplasmic antibodies and associated diseases: a review of the clinical and laboratory features. (eurekaselect.com)
- 1. Russell KA, Wiegert E, Schroeder DR, et al: Detection of anti-neutrophil cytoplasmic antibodies under actual clinical testing conditions. (testcatalog.org)
- Vasculitis is a heterogeneous disease that has common clinical manifestation such as fibrinoid necrosis and inflammation of the blood vessels. (researchandmarkets.com)
Immunofluorescence1
- The interpretation of the antibody staining pattern using indirect immunofluorescence can be complicated by the presence of other antibodies. (thecardiologyadvisor.com)
Diagnosis6
- We again performed a biopsy of the perforated nasal septum for differential diagnosis, which revealed an infiltration of inflammatory cells, including neutrophils and lymphocytes, with no evidence of malignancy or granulomatous change. (thefreelibrary.com)
- Currently, they are widely considered as a laboratory test biomarker in the diagnosis of patients suspected with vasculitis. (termedia.pl)
- The Novel Fibrosis Index at Diagnosis May Predict All-cause Mortality in Patients With Antineutrophil Cytoplasmic Antibody-associated Vasculitis Without Substantial Liver Diseases. (researchsquare.com)
- Its detection was helpful in diagnosis and management of vasculitides with renal and extrarenal manifestations. (bvsalud.org)
- Methods: We included patients enrolled in the Diagnostic and Classification Criteria for Primary Systemic Vasculitis (DCVAS) study between October 2010 and January 2017 with a diagnosis of AAV. (elsevier.com)
- Determination of anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and negative ANCAs are not sufficient to reject the diagnosis. (wikipedia.org)
Pauci-immune glomerulonephritis1
- Shah S, Havill J, Rahman MH, Geetha D (2016) A historical study of American patients with anti-neutrophil cytoplasmic antibody negative pauci-immune glomerulonephritis. (springer.com)
Cyclophosphamide5
- Current standard of care for the initial treatment of AAV is glucocorticoids in combination with either cyclophosphamide (CYC) or the B cell depleting antibody, rituximab. (springer.com)
- Cyclophosphamide is typically given by vein every 4 weeks for at least 3 months, but sometimes longer depending on whether the vasculitis is still active or not. (clinicaltrials.gov)
- The current therapeutic regimen recommended by the European League against Rheumatism (EULAR) for anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is continuation of initially administered doses of glucocorticoids (GCs) in combination with cyclophosphamide (CYC) for 1 month followed by gradual tapering. (elsevier.com)
- Mycophenolate Mofetil Versus Cyclophosphamide for the Induction of Remission in Nonlife-Threatening Relapses of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Randomized, Controlled Trial. (nih.gov)
- Cyclophosphamide is still the drug of choice for the treatment of vasculitis used in combination with prednisolone globally, highly recommended in patients showing resistance to rituximab treatment. (researchandmarkets.com)
Vessel vasculitis7
- Necrotizing arteritis is common to many forms of vasculitis, but involvement of vessels smaller than arteries is unique to small vessel vasculitis. (intechopen.com)
- Magnetic resonance imaging showed diffuse cortico-subcortical lesions with T2 and proton density hypersignal suggesting recent ischemia, and segmental irregularities of various cerebral and vertebral arteries, consistent with small and medium size vessel vasculitis. (mec.pt)
- Large vessel vasculitis majorly consists of giant cell arteritis and Takayasu arteritis that are highly prevalent in Norway and Germany. (researchandmarkets.com)
- Medium vessel vasculitis comprises polyarteritis nodusa which affects in all age group and mostly half of diagnosed cases have been related to HBV infection. (researchandmarkets.com)
- Large vessel vasculitis dominated the disease type segment in 2017 on account of increasing number of immunocompromised patients suffering with large vessel vasculitis and rising prevalence of CD4 T cell mediated Takayasu vasculitis in the Caucasian population. (researchandmarkets.com)
- North America dominated the vasculitis treatment market owing to the rising prevalence of large vessel vasculitis such as giant cell arteritis and Takayasu arteritis, developed healthcare infrastructure and domicile to key players actively engaged in the drug discovery for vasculitis treatment. (researchandmarkets.com)
- Asia Pacific is set to register excellent growth during the forecast period due to increasing number of geriatric population suffering with small vessel vasculitis, proactive government initiatives to expedite the research activities related to vasculitis treatment and increasing disposable income making it affordable for the ailing patient to receive optimum treatment. (researchandmarkets.com)
Glomerulonephritis1
- Patients can present with a dry cough, hemoptysis, bilateral diffuse lung infiltrate revealed by a chest X ray, sinusitis, otitis, cutaneous vasculitis, or a rapidly progressive glomerulonephritis. (infectiousdiseaseadvisor.com)
Relapse3
- No relapse of vasculitis occurred during follow-up, even after withdrawal of immunosuppressive therapy. (scienceopen.com)
- For uncontrolled hyperthyroidism on presentation, six patients switched to methimazole and none of them experienced relapse of vasculitis. (scienceopen.com)
- Vasculitis relapse was defined as the PSE of either a BVAS activity score of ≥6 or receipt of prohibited medications for vasculitis. (ox.ac.uk)
Ethanol-fixed neutrophils2
- Autoantibodies to PR3 occur in patients with WG (both classical WG and WG with limited end-organ involvement) and produce a characteristic pattern of granular cytoplasmic fluorescence on ethanol-fixed neutrophils called the cANCA pattern. (testcatalog.org)
- Antibodies to MPO occur predominately in patients with MPA and produce a pattern of perinuclear cytoplasmic fluorescence on ethanol-fixed neutrophils called the pANCA pattern. (testcatalog.org)
Primary systemic necrotizing1
- The primary systemic necrotizing vasculitides are a group of life-threatening diseases that, untreated, have an 85% 2-yr mortality. (asnjournals.org)
Leukocytoclastic vasculitis1
- Skin biopsies show leukocytoclastic vasculitis when purpuric lesions are biopsied ( Figure 3 ). (oncologynurseadvisor.com)
Involvement2
- Localised or diffuse pulmonary infiltrates, lobar collapse, atelectasis, and alveolar haemorrhage are other common manifestations of pulmonary involvement in systemic vasculitis. (bmj.com)
- CNS involvement is an uncommon but serious complication and it often arises when vasculitis is active elsewhere 7,8 . (mec.pt)
Small vessels2
- This is a disease characterized by necrotizing vasculitis affecting small vessels. (infectiousdiseaseadvisor.com)
- There are several vasculitides that affect small vessels. (wikipedia.org)
Glucocorticoids1
- Patient perceptions of glucocorticoids in anti-neutrophil cytoplasmic antibody-associated vasculitis. (ox.ac.uk)
Inflammation6
- The vasculitides comprise a heterogeneous group of diseases characterized by inflammation and destruction of blood vessels. (intechopen.com)
- Ulcerations may demonstrate vasculitis, including granulomatous vasculitis or may show granulomatous inflammation without vasculitis. (oncologynurseadvisor.com)
- Furthermore, treatment with anti-TNFα therapy abrogates inflammation in an animal model of human renal vasculitis in vivo ( 8 ). (asnjournals.org)
- Granulomatous inflammation involves the respiratory track and necrotizing vasculitis affecting small to medium size vessels (venules and arterioles). (infectiousdiseaseadvisor.com)
- This is a disorder marked by eosinophil-rich and granulomatous inflammation involving the respiratory track and necrotizing vasculitis involving small to medium size vessels. (infectiousdiseaseadvisor.com)
- It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in GPA. (wikipedia.org)
20183
- Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis," Case Reports in Rheumatology , vol. 2018, Article ID 8192021, 4 pages, 2018. (hindawi.com)
- Vasculitis - Pipeline Insight, 2018' report offers comprehensive Insight of the pipeline (under development) therapeutics scenario and growth prospects across Vasculitis development. (researchandmarkets.com)
- Vasculitis Treatment Market - Growth, Future Prospects, Competitive Analysis, 2018 - 2026, the global vasculitis treatment market was valued at US$ 365.1 Mn in 2017 and expected to reach US$ 601.2 Mn by 2026, expanding at a CAGR of 5.7% from 2018 to 2026. (researchandmarkets.com)
Wegener's Granulomatosis3
- Ludemann J, Utecht B, Gross WL (1990) Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. (springer.com)
- The, T.H. Association between active Wegener's granulomatosis and anticytoplasmic antibodies. (eurekaselect.com)
- The lung is frequently involved in primary vasculitis especially in Wegener's granulomatosis. (bmj.com)
Pathogenesis1
- Tumor necrosis factor α (TNFα) plays an important role in the pathogenesis of anti-neutrophil cytoplasmic antibody-associated systemic vasculitis. (asnjournals.org)
Patients11
- Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies. (lu.se)
- 3] described similar patterns of autoantibodies in patients with systemic vasculitis (GPA) in 1985. (termedia.pl)
- Conclusion: TNFα blockade with infliximab was effective at inducing remission in 88% of patients with antibody-associated systemic vasculitis and permitted reduction in steroid doses. (asnjournals.org)
- We studied the safety and efficacy of TNFα inhibition with infliximab in the therapy of AASV for the control of disease flares (study I) and in the longer-term control of vasculitis in patients with persistent disease activity despite conventional therapy (study II). (asnjournals.org)
- Extra-renal organ manifestations and respiratory track granulomas occur more frequently in patients with anti-PR3 than those with anti-MPO. (infectiousdiseaseadvisor.com)
- The frequencies of polymorphonuclear leukocytes (PMN) ( a ), neutrophils ( b ), eosinophils ( c ), and basophils ( d ) were investigated in healthy blood donors (HBD) and anti-neutrophil cytoplasmic antibodies associated vasculitides (AAV) patients using flow cytometry. (biomedcentral.com)
- Results: In the comparison analysis, patients with severe AAV exhibited the higher neutrophil and platelet counts, creatinine, erythrocyte sedimentation rate and C-reactive protein, and the lower lymphocyte count, hemoglobin, and serum albumin than those without. (elsevier.com)
- Long-term outcomes of patients with propylthiouracil-induced anti-neutrophil cytoplasmic auto-antibody-associated vasculitis. (scienceopen.com)
- Results All patients had severe active vasculitis at screening (mean ± SD BVAS/WG score 8.6 ± 3.2). (elsevier.com)
- Damage accrual, measured with the Vasculitis Damage Index (VDI), was significantly higher in older patients, 12% of whom had a 6 month VDI ≥5, compared with 7% of younger patients (P = 0.01). (elsevier.com)
- Patients have CNS symptoms as well as cerebral vasculitis by angiography and leptomeningeal biopsy. (wikipedia.org)
Rheumatology1
- The initial classification system proposed by the American College of Rheumatology attempted to classify vasculitis according to standardized criteria. (intechopen.com)
Disease8
- While the immunological basis of disease for vasculitis was recognized over thirty years ago,[ 1 ] a standardized classification system was only adopted nearly twenty years later. (intechopen.com)
- 2 ] The subsequent system described by the Chapel Hill Conference on the Nomenclature of Systemic Vasculitis[ 3 ] introduced a system which coupled contemporary commonly used disease names and the size of vessel(s) involved. (intechopen.com)
- 7 ] In the 1980s it was appreciated that the small vessel vasculitides represented a clinically distinct form of disease. (intechopen.com)
- Infliximab is a promising new therapy for vasculitis both as a component of initial therapy and in the management of refractory disease. (asnjournals.org)
- Compassionate-use studies have reported improvements in disease activity in AASV using both the anti-TNFα monoclonal antibody infliximab ( 9-11 ⇓ ⇓ ) and the soluble p75 receptor etanercept. (asnjournals.org)
- Antineutrophil cytoplasmic antibody associated vasculitis (AAV) is a fatal disease. (researchsquare.com)
- University of Tsukuba-led team reveals the association between a gene variant and a lung disease in the form of systemic vasculitis particularly prevalent in the Japanese, potentially providing a target for future therapies. (news-medical.net)
- Low levels of IgM auto-antibodies have been reported in health and disease. (nih.gov)
Heterogeneous1
- Anti-neutrophil cytoplasmic antibody-associated vasculitides refer to a group of heterogeneous autoimmune diseases characterized by necrotizing vasculitides and positive anti-neutrophil antibody titers. (radiopaedia.org)
Biopsy1
- Histological findings of the biceps muscle biopsy, which showed muscle damage by MRI, showed necrotizing vasculitis of the medium-sized artery without small or capillary lesions. (beds.ac.uk)
Perinuclear1
- and of low titre and cytoplasmic or perinuclear type in systemic polyarteritis (6/12), renal limited polyarteritis (5/9) and pulmonary renal syndrome (1/2). (bvsalud.org)
Activate neutrophils1
- In vitro studies have found that ANCAs can activate neutrophils, increase their adherence to endothelium, and induce their degranulation that can damage endothelial cells. (wikipedia.org)
Group of autoantibodies1
- Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes. (wikipedia.org)
French Vasculitis Study Group2
- Founder of the French Vasculitis Study Group (FVSG) counting over 600 French physicians and with strong international contacts. (springer.com)
- This study was undertaken to evaluate the applicability of those predictors in an independent cohort followed up by the French Vasculitis Study Group. (nih.gov)
Cutaneous3
- Other extra-renal symptoms may include cutaneous vasculitis or mononeuritis multiplex. (infectiousdiseaseadvisor.com)
- Systemic features can include cutaneous vasculitis lesions, neuropathy, paranasal sinus abnormality, or pulmonary infiltrates. (infectiousdiseaseadvisor.com)
- Arthritis: Pain or swelling (60%), often initially diagnosed as rheumatoid arthritis Skin: subcutaneous nodules (granulomas) on the elbow, purpura, various others (see cutaneous vasculitis) Nervous system: occasionally sensory neuropathy (10%) and rarely mononeuritis multiplex Heart, gastrointestinal tract, brain, other organs: rarely affected. (wikipedia.org)
Monoclonal antibody1
- Eculizumab is a monoclonal antibody that targets a key component of the complement pathway named C5, and blocks its activation. (clinicaltrials.gov)
Granulocytes1
- The typical ANCAs in GPA are those that react with proteinase 3, an enzyme prevalent in neutrophil granulocytes. (wikipedia.org)
CANCA1
- Cytoplasmic-staining ANCAs that react with the enzyme proteinase 3 (cANCA) in neutrophils (a type of white blood cell) are associated with GPA. (wikipedia.org)
Polyarteritis1
- WG must be differentiated from other systemic vasculitis syndromes including Churg-Strauss granulomatosis, polyarteritis nodosum, and others. (oncologynurseadvisor.com)
Severe1
- As the treatment of severe COVID-19 is very difficult, the researchers from the Korea Research Institute of Biosciences and Biotechnology (KRIBB) suggested that DNase-1 can be utilized to dissolve the neutrophil extracellular traps (NETs), hence halting the further progression of COVID-19. (news-medical.net)
Necrotizing3
- Based on the above findings, the patient was diagnosed with PAN, a necrotizing vasculitis confined to medium-sized arteries. (beds.ac.uk)
- Necrotizing vasculitis also called Systemic necrotizing vasculitus ( SNV ) [1] is a category of vasculitis , [2] comprising vasculitides that present with necrosis . (wikipedia.org)
- Systemic necrotizing vasculitis and aneurysm formation affecting both medium and small arteries. (wikipedia.org)
Pulmonary1
- Imaging of pulmonary vasculitis. (radiopaedia.org)
Arterioles2
- These vasculitides affect arterioles, capillaries, and venules which can involve virtually any organ with varying degrees of severity. (radiopaedia.org)
- Systemic vasculitis of medium and small arteries, including venules and arterioles. (wikipedia.org)
Induction1
- NET induction activity was high in Sera A, B, and C but not in D. Additionally, we demonstrated the presence of anti-NET antibody (ANETA) in Sera B and C but not in A or D. (biomedcentral.com)