Antibodies, Antineutrophil Cytoplasmic: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Myeloblastin: A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.Wegener Granulomatosis: A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.Microscopic Polyangiitis: A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.Churg-Strauss Syndrome: Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.Polyarteritis Nodosa: A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.Systemic Vasculitis: A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Retinal Vasculitis: Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.Vasculitis, Central Nervous System: Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Propylthiouracil: A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Antithyroid Agents: Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.Neutrophil Infiltration: The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Arteritis: INFLAMMATION of any ARTERIES.Cathepsin G: A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Endocarditis, Subacute Bacterial: ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.Purpura, Schoenlein-Henoch: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Lactoferrin: An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.Antibodies, Fungal: Immunoglobulins produced in a response to FUNGAL ANTIGENS.N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.Epitopes: Sites on an antigen that interact with specific antibodies.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Rheumatoid Vasculitis: Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ULCERS, peripheral GANGRENE, and MONONEURITIS MULTIPLEX.Nose Diseases: Disorders of the nose, general or unspecified.Plasma Exchange: Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Leukocyte Elastase: An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Antibodies, Monoclonal, Murine-Derived: Antibodies obtained from a single clone of cells grown in mice or rats.Binding Sites, Antibody: Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.Hemoptysis: Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.Lung Diseases: Pathological processes involving any part of the LUNG.Chemotaxis, Leukocyte: The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.Neutrophil Activation: The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.Lysosomal-Associated Membrane Protein 2: An abundant lysosomal-associated membrane protein that has been found to shuttle between LYSOSOMES; ENDOSOMES; and the PLASMA MEMBRANE. Loss of expression of lysosomal-associated membrane protein 2 is associated with GLYCOGEN STORAGE DISEASE TYPE IIB.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Cryoglobulinemia: A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.HIV Antibodies: Antibodies reactive with HIV ANTIGENS.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Scleritis: Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).Antibodies, Neoplasm: Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.Anti-Glomerular Basement Membrane Disease: An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.Antibodies, Protozoan: Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.Fixatives: Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.Eosinophilia-Myalgia Syndrome: A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cathepsins: A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Mice, Inbred BALB CLevamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Bronchiectasis: Persistent abnormal dilatation of the bronchi.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Antigens, CD18: Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Hemorrhage: Bleeding or escape of blood from a vessel.Proctocolectomy, Restorative: A surgical procedure involving the excision of the COLON and RECTUM and the formation of an ILEOANAL RESERVOIR (pouch). In patients with intestinal diseases, such as ulcerative colitis, this procedure avoids the need for an OSTOMY by allowing for transanal defecation.Recurrence: The return of a sign, symptom, or disease after a remission.Drug Contamination: The presence of organisms, or any foreign material that makes a drug preparation impure.Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.Immunologic Factors: Biologically active substances whose activities affect or play a role in the functioning of the immune system.Necrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Cell Adhesion: Adherence of cells to surfaces or to other cells.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.Superoxides: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Tissue Fixation: The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.Hepatitis, Autoimmune: A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Antimicrobial Cationic Peptides: Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.Chemotactic Factors: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.Respiratory Burst: A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antigen-Antibody Reactions: The processes triggered by interactions of ANTIBODIES with their ANTIGENS.Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.Macrophage-1 Antigen: An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN. The antigen, which is an integrin, functions both as a receptor for complement 3 and in cell-cell and cell-substrate adhesive interactions.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Adrenal Cortex HormonesAntibodies, Blocking: Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Antibodies, Bispecific: Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.Cryoglobulins: Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Syndrome: A characteristic symptom complex.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Formaldehyde: A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)Pancreatic Elastase: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.Single-Chain Antibodies: A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)Purpura: Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).Giant Cell Arteritis: A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Antibodies, Heterophile: Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.Antibodies, Catalytic: Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.Epitope Mapping: Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Complement System Proteins: Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).Kinetics: The rate dynamics in chemical or physical systems.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Antibodies, Antiphospholipid: Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Takayasu Arteritis: A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Arthus Reaction: A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.Antigens: Substances that are recognized by the immune system and induce an immune reaction.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Complement C5a: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.Cytoplasmic Granules: Condensed areas of cellular material that may be bounded by a membrane.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Molecular Weight: The sum of the weight of all the atoms in a molecule.Plasmapheresis: Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.Hybridomas: Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.ZymosanChemokine CXCL1: A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Receptors, Interleukin-8B: High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Cell Degranulation: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.

Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts. (1/99)

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Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors. (2/99)

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CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis. (3/99)

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Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: a matched-pair cohort study. (4/99)

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Small vessel vasculitis. (5/99)

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Spontaneous resolution of delayed onset large subclavian artery pseudoaneurysm. (6/99)

A 70-year-old woman with a history of end-stage renal disease secondary to anti-neutrophil cytoplasmic autoantibody-associated vasculitis had been receiving hemodialysis for 5 years. The patient underwent attempted right internal jugular vein cannulation for temporary hemodialysis catheter placement. Pulsating mass developed in the neck and angiography revealed a subclavian artery pseudoaneurysm 4 days later. The pseudoaneurysm disappeared spontaneously during the interval between the diagnosis and the planned surgical procedure. Such delayed onset and spontaneous resolution of subclavian artery pseudoaneurysm is uncommon. Close observation may be optimal if delayed onset of pseudoaneurysm occurs after small needle puncture with cessation of antiplatelet/anticoagulant administration.  (+info)

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (7/99)

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Prediction of ESRD in pauci-immune necrotizing glomerulonephritis: quantitative histomorphometric assessment and serum creatinine. (8/99)

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*Eosinophilic granulomatosis with polyangiitis

Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody-associated vasculitis: a ... and antineutrophil cytoplasmic antibodies (ANCA) against neutrophil granulocytes. The American College of Rheumatology 1990 ... The third stage consists of vasculitis, which can eventually lead to cell death and can be life-threatening. This condition is ... It is a type of systemic necrotizing vasculitis. Effective treatment of EGPA requires suppression of the immune system with ...

*Anti-neutrophil cytoplasmic antibody

Stegeman, CA (Nov 2005). "Predictive value of antineutrophil cytoplasmic antibodies in small-vessel vasculitis: is the glass ... Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the ... images of pANCA and cANCA fluorescence images of ANCA Anti-Neutrophil Cytoplasmic Antibody at the US National Library of ... Jennette, JC; Xiao, H; Falk, RJ (May 2006). "Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies". ...

*Granulomatosis with polyangiitis

Determination of Anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and ... Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a ... It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in GPA. ... "The antineutrophil cytoplasmic antibody-associated vasculitides". Am. J. Med. 117 (1): 39-50. doi:10.1016/j.amjmed.2004.02.030 ...

*P-ANCA

... , or MPO-ANCA, or Perinuclear Anti-Neutrophil Cytoplasmic Antibodies, are antibodies that stain the material around the ... These include lactoferrin; elastase; and cathepsin G. When the condition is a vasculitis, the target is usually MPO. However, ... They are a special class of Anti-Neutrophil Cytoplasmic Antibodies. This pattern occurs because the vast majority of the ... Focal necrotizing and crescentic glomerulonephritis Rheumatoid arthritis C-ANCA Anti-Neutrophil Cytoplasmic Antibody (ANCA) ...

*Necrotizing vasculitis

Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a ... drug in relation to symptoms palpable purpura maculopapular rash skin biopsy showing neutrophils around vessel IgA vasculitis ( ... A systematic review of antineutrophil cytoplasmic antibody (ANCA) positive vasculitis identified best treatments depending on ... but not most other vasculitides. Antineutrophil cytoplasmic antibody (ANCA) may highly suggest granulomatosis with polyangiitis ...

*Myeloperoxidase

Antibodies are also known as anti-neutrophil cytoplasmic antibodies (ANCAs), though ANCAs have also been detected in staining ... "Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis". Current Opinion in ... Antibodies against MPO have been implicated in various types of vasculitis, most prominently three clinically and ... Neutrophil verdoperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and ...

*Microscopic polyangiitis

October 2002). "Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis ... Then, the large number of antibodies make it more likely that they will bind a neutrophil. Once bound, the neutrophil ... An important diagnostic test is the presence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) with myeloperoxidase ... Most recently, two different groups of investigators have demonstrated that anti-MPO antibodies alone can cause necrotizing and ...

*Rapidly progressive glomerulonephritis

... and type III and idiopathic RPGN are frequently associated with anti-neutrophil cytoplasmic antibodies (ANCA)-positive serum. ... the systemic disease is an ANCA-associated vasculitis such as granulomatosis with polyangiitis, microscopic polyangiitis or ... antineutrophil cytoplasmic antibodies specificity is determined via (ELISA), with pANCA(antibody) directed against MPO Serum ... The presence of anti-Glomerular basement membrane (GBM) antibodies suggests type I RPGN; antinuclear antibodies (ANA) may ...

*Ronald J. Falk

"Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and ... March 2012). "Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody ... Falk, RJ; Terrell, RS; Charles, LA; Jennette, JC (June 1990). "Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to ... As an investigator, Falk studies kidney diseases caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs), which are a ...

*Hypereosinophilia

Zhang J, Zhang HY, Chen SZ, Huang JY (2016). "Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and ... eosinophilic vasculitis, and eosinophilic ulcer of the oral mucosa. Other examples of organ-restricted hepereosinophilia ... Afflicted tissues exhibit acute inflammation involving eosinophils, neutrophils, monocytes, lymphocytes, and plasma cells. The ... elevated blood levels of IgM antibodies, and clonal expansion of T cells. Similar to lymphocyte=variant hypereosinophilia, the ...
H1 2017 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review Report provides top level data related to the clinical trials by Region, Country (G7 & E7), Trial Status, Trial Phase, Sponsor Type and End point status.
ContextImmunosuppressive therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis have greatly advanced patient survival but have turned A
Evidence-based recommendations on rituximab (MabThera) with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis
Evidence-based recommendations on rituximab (MabThera) with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis
Background Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical service. Therapies for AAV are imperfect with many patients failing to...
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
Wet-lab validated real-time PCR primer assays for your biological pathway of interest. Select your gene target of interest using an interactive pathway map, and select your plate.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides are a heterogeneous group of diseases corresponding to necrotising inflammation of small vessels with a wide range of clinical presentations. At least two of the diseases are believed to exhibit a common ground of pathophysiological mechanisms. These are granulomatosis with polyangiitis (GPA, formerly known as Wegeners granulomatosis) and microscopic polyangiitis (MPA). ANCA directed against proteinase 3 (PR3) are preferentially associated with GPA, and anti-myeloperoxidase (MPO) ANCA are associated mainly with MPA and eosinophilic GPA (formerly known as Churg-Strauss syndrome). Anti-MPO and anti-PR3 antibodies can activate neutrophils in vitro. In vivo data are available for humans and mice on the pathogenicity of anti-MPO but it is more controversial for PR3-ANCA. A recent genome-wide association study of patients with ANCA-associated vasculitides confirmed the genetic contribution to the pathogenesis of these conditions, with ...
Objective. Treatment resistance and relapse in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are major challenges for physicians. The aim of this study was to assess the risk factors for treatment resistance and relapse in a single-center cohort of Chinese patients with AAV.. Methods. Four hundred thirty-nine consecutive patients with AAV were recruited for inclusion in this study. The value of various clinical and pathologic parameters for the prediction of treatment resistance and relapse was analyzed.. Results. Treatment resistance occurred in 47 (10.7%) of 439 patients and was independently associated with a higher serum creatinine level (odds ratio [OR] 1.087, 95% confidence interval [95% CI] 1.001-1.180, P = 0.047), a higher erythrocyte sedimentation rate (OR 1.009, 95% CI 1.001-1.018, P = 0.025), therapy with corticosteroids plus cyclophosphamide (OR 0.115, 95% CI 0.051-0.256, P = 0.000), and the presence of muscle pain (OR 0.249, 95% CI 0.083-0.747, P = 0.013). ...
We report the first case of renal antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis treated with autologous mesenchymal stromal cells (MSCs). A 73-year-old man was admitted to the hospital for malaise, weight loss, and oliguria. His se
The next 3 papers were recently published in NDT. M Huber et al first discuss "Should belatacept be the centrepiece of renal transplantation?". Then J Perl et al report on "Association between changes in quality of life and mortality in hemodialysis patients: results from the DOPPS". And JF Sanders et al report on "Extended versus standard azathioprine maintenance therapy in newly diagnosed proteinase-3 anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody-positive after induction of remission: a randomized clinical trial ...
Plasminogen antibody (Biotin) (plasminogen) for ELISA, WB. Anti-Plasminogen pAb (GTX79699) is tested in Human samples. 100% Ab-Assurance.
Results During the 2650 person-years observation period, 50 cancers were diagnosed in 46 patients. SIR (95% CI) were 1.58 (1.17 to 2.08) for cancers at all sites, 1.30 (0.90 to 1.80) for cancers at all sites excluding non-melanoma skin cancer (NMSC), 2.41 (0.66 to 6.17) for bladder cancer, 3.23 (0.39 to 11.65) for leukaemia, 1.11 (0.03 to 6.19) for lymphoma and 2.78 (1.56 to 4.59) for NMSC. Subgroup SIR for cancers at all sites were 1.92 (1.31 to 2.71) for GPA and 1.20 (0.71 to 1.89) for MPA.. ...
Introduction: Evidence from a number of open-label, uncontrolled studies has suggested that rituximab may benefit patients with autoimmune diseases who are refractory to standard-of-care. The objective of this study was to evaluate the safety and clinical outcomes of rituximab in several standard-of-care-refractory autoimmune diseases (within rheumatology, nephrology, dermatology and neurology) other than rheumatoid arthritis or non-Hodgkins lymphoma in a real-life clinical setting. Methods: Patients who received rituximab having shown an inadequate response to standard-of-care had their safety and clinical outcomes data retrospectively analysed as part of the German Registry of Autoimmune Diseases. The main outcome measures were safety and clinical response, as judged at the discretion of the investigators. Results: A total of 370 patients (299 patient-years) with various autoimmune diseases (23.0% with systemic lupus erythematosus, 15.7% antineutrophil cytoplasmic antibody-associated ...
Purpose: Combined use of cyclophosphamide (CYC) and glucocorticoids (GCS) has been the standard of care for remission induction for ANCA-associated vasculitis (AAV) for decades. Uncontrolled studies suggest rituximab (RTX) may be effective for AAV, and its use may avoid some of the toxicities associated with CYC therapy. This trial compares the efficacy of RTX to that of CYC for AAV.. Method: A multicenter, randomized, double-blind, placebo-controlled trial was conducted to determine if treatment with RTX (375 mg/m2 i.v. weekly x 4) was not inferior to CYC (2 mg/kg/d p.o.) for inducing remission in severe AAV. Once remission was achieved, CYC was replaced by azathioprine between months 3-6. All patients received the same GCS treatment protocol: 1-3 g i.v. methylprednisolone followed by prednisone 1 mg/kg/d p.o. reduced to 40 mg/d by month 1, and then tapered and discontinued completely by month 6. The primary endpoint was disease remission in the absence of prednisone therapy at month 6. ...
Mouse monoclonal Plasminogen antibody [3C2] validated for ELISA, IHC, Flow Cyt, Other and tested in Human. Referenced in 2 publications and 1 independent…
--Oral presentation at the American Society of Nephrology Kidney Week 2016 to highlight Phase II AAV CLEAR trial results--. --Oral presentation at the American College of Rheumatology 2016 Annual Meeting to highlight Phase II AAV CLASSIC trial results--. MOUNTAIN VIEW, Calif., Nov. 07, 2016-- ChemoCentryx, Inc.,, today announced oral presentations at two upcoming...
MOUNTAIN VIEW, Calif., June 2, 2014 (GLOBE NEWSWIRE) -- ChemoCentryx, Inc., (Nasdaq:CCXI) reported today additional Phase II data related to CCX168, an orally administered inhibitor that targets the receptor for the complement protein known as C5a (C5aR). Data were presented in an oral presentation at the 51
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国内在庫あります!FITC標識済みシープ・ポリクローナル抗体 ab27617 交差種: Hu 適用: ICC/IF…Plasminogen抗体一覧 一次抗体にFITCを直接標識し、操作時間の短縮と低いバックグラウンドを実現。
The abstract of this paper is available from the Lancet. However, you must register at the Lancet site first as a non-subscriber (you can get there via the journals page of HDCN ...
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OBJECTIVES: To study serum levels of leptin and ghrelin in ANCA-associated vasculitis (AAV). METHODS: Thirty-seven patients with AAV (21 patients with active AAV at initial presentation and during follow-up, 16 patients with AAV in long-term remission) and 21 matched healthy controls were included. Serum levels of leptin and ghrelin were measured at 0, 6 and 12 months by radioimmunoassay. Disease activity was gauged by Birmingham Vasculitis Activity Score (BVAS), CRP and circulating endothelial cells (CECs). RESULTS: Leptin levels were significantly lower in patients than in healthy controls (9.1 +/- 6.1 vs 22.3 +/- 22.4 ng/ml; P , 0.05). The difference persisted when corrected for BMI. Leptin levels increased significantly after 6 (27.8 +/- 21.9 ng/ml; P , 0.001) and 12 months (24.6 +/- 21.0 ng/ml; P , 0.001). Ghrelin levels were significantly elevated in patients compared with controls (402.6 +/- 112.9 vs 294.8 +/- 70.9 pmol/l; P , 0.005) and declined to normal values at 12 months (306.4 +/- ...
The primary safety objective of this study is to evaluate the safety and tolerability of CCX168 in subjects with AAV on background cyclophosphamide or rituximab treatment.. The primary efficacy objective is to evaluate the efficacy of CCX168 based on the Birmingham Vasculitis Activity Score (BVAS) version 3.. The secondary objectives of this study include assessment of the feasibility of reducing or eliminating the use of corticosteroids in the treatment of subjects with ANCA-associated vasculitis without the need for rescue corticosteroid measures and the effect of CCX168 on several disease parameters. ...
In this study, we investigated the mechanism of platelet activation in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), as well as the activation of the alternative complement pathway by platelets in AAV. CD62P and platelet-leukocyte aggregates in AAV patients were tested by flow cytometry. Platelets were stimulated by plasma from active AAV patients. The effect of the thrombin-protease-activated receptors (PARs) pathway was evaluated by blocking thrombin or PAR1 antagonists. After platelets were activated by plasma from AAV patients, Ca/Mg-Tyrodes buffer and Mg-EGTA buffer were used to measure complement activation in liquid phase and on the surface of platelets. The levels of CD62P-expressing platelets and platelet-leukocyte aggregates were significantly higher in active AAV patients than those in remission and normal controls. Platelets were activated by plasma from active AAV patients (percentage of CD62P-expressing platelets, 97.7 ± 3% vs. 1 ± 0.2%, p | 0
Most patients with ANCA-associated vasculitis will not present with visual or other overt signs of renal involvement: macroscopic haematuria is usually absent as one of the presenting symptoms and proteinuria is frequently mild, not leading to the clinical signs of nephrotic syndrome. This is also nicely illustrated by the paper by Houben as only 21 of the patients from their cohort were diagnosed by the renal department. This means that patients present with combinations of other signs and symptoms and are referred to other disciplines. Renal involvement, therefore, has to be actively investigated once the diagnosis of ANCA-associated vasculitis is suspected. This means that in every patient in whom the diagnosis of ANCA-associated vasculitis is seriously considered, assessment of renal function (serum creatinine, estimated glomerular filtration rate (eGFR), 24-hour urine creatinine clearance) and urinalysis (erythrocyturia and if present urinary microscopy for glomerular erythrocyturia and/or ...
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Two UNC School of Medicine faculty authored an editorial in the July 15, 2010 New England Journal of Medicine commenting on results from two clinical trials using the drug Rituximab to treat small-vessel vasculitis, a rare autoimmune disease.. The trials took place in the United States "" Rituximab in ANCA-Associated Vasculitis (RAVE) -- and in Europe -- Rituximab versus cyclophosphamide in ANCA-Associated renal vasculitis (RITUXIVAS). Both trials showed that rituximab was effective in inducing a remission, compared with intravenous cytoxan, used in the RITUXIVAS trial, or oral cyclophosphamide, used in the RAVE trial.. Rituximab is used to treat non-Hodgkins lymphoma by targeting a specific protein on the surface of B lymphocytes, a type of immune cell. A different B-cell protein is the target of vasculitis.. Ronald J. Falk, MD, professor of medicine and director of the UNC Kidney Center, and Charles Jennette, MD, professor and chair of the department of pathology and laboratory medicine, are ...
Despite their limitations, the current animal models of ANCA vasculitis are likely to be useful for further elucidation of mechanisms and factors involved in disease pathogenesis and for identifying targets for treatment. In this respect, the murine model is likely to be useful in identifying therapeutic targets at the point of acute vascular injury, whereas the EAV rat model may be more useful in identifying therapies that can be administered over a more prolonged period of time to disrupt the MPO-specific immune response. The most pressing current need is the development of a reliable model of anti-Pr3-associated vasculitis. In addition, we believe that the following issues will be important to address over the coming 5 to 10 years:. The crucial role of neutrophils in ANCA-SVV pathogenesis is well established but other effector cells are likely to contribute as well. Besides neutrophils, ANCAs can activate monocytes in vitro to produce oxygen radicals [51], proinflammatory cytokines, and ...
The main result of our analysis is that in AAV patients with predominant renal and pulmonary involvement, comorbidity score independently predicted short term survival. It also proved to be a predictor of infectious mortality. On protocolized immunosuppressive therapy, patients, who had high BVAS at baseline, had significantly poorer short term survival and more frequent relapses than subjects with lower than median score. When analyzing early and late mortality separately, BVAS did not predict outcome in univariable analysis.. BVAS, originally designed to standardize disease assessment in AAV, shows good correlation with clinical activity of the disease [8]. Flossmann et al. documented, that BVAS was a significant predictor of mortality by analyzing the data of patients recruited for randomized controlled trials. Patients in that study were somewhat different from the ones enrolled in ours, since the median BVAS was lower, renal function was less severely compromised, and subjects with ...
Abstract OBJECTIVE: The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors and a major cause of morbidity and mortality in the western world. Despite the fact th..
Antibody-mediated and paraneoplastic autoimmune encephalitides (AE) present with a broad spectrum of clinical symptoms. They often lead to progressing inflammatory changes of the central nervous system with subacute onset and can cause persistent brain damage. Thus, to promptly start the appropriate and AE-specific therapy, recognition of symptoms, initiation of relevant antibody diagnostics and confirmation of the clinical diagnosis are crucial, in particular as the diseases are relatively rare. This standard operating procedure (SOP) should draw attention to the clinical presentation of AE, support the diagnostic approach to patients with suspected AE and guide through the necessary steps including therapeutic decisions, tumour screening and exclusion of differential diagnoses. Based on existing diagnostic algorithms, treatment recommendations and personal experiences, this SOP gives an overview of clinical presentation, diagnostic procedures and therapy in AE. Additional information is provided
SAN DIEGO -- Mycophenolate mofetil (CellCept) proved non-inferior to cyclophosphamide (Cytoxan) for treating ANCA-associated vasculitis in a regimen that permitted use of glucocorticoids, but not in o
国内在庫あります!Biotin標識済みウサギ・ポリクローナル抗体 ab48364 交差種: Ms 適用: WB,IP,RIA…Plasminogen抗体一覧 一次抗体にBiotinを直接標識し、操作時間の短縮と低いバックグラウンドを実現。
Anti-Neutrophil antibody [NIMP-R14] (ab2557) has been cited in 70 publications. References for Human, Mouse in IF, IHC, IHC-Fr, IHC-P
TY - JOUR. T1 - Low serum complement 3 level is associated with severe ANCA-associated vasculitis at diagnosis. AU - Choi, Hyeok. AU - Kim, Youhyun. AU - Jung, Seung Min. AU - Song, Jason Jungsik. AU - Park, Yong Beom. AU - Lee, Sang Won. PY - 2019/2/15. Y1 - 2019/2/15. N2 - Objectives: We investigated whether low serum C3 level can cross-sectionally estimate severe antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in immunosuppressive drug-naïve patients at diagnosis. Methods: We retrospectively reviewed the medical records of 139 patients with AAV, who were first classified as AAV at Severance Hospital. We obtained clinical and laboratory data including serum complement 3 (C3) level and calculated Birmingham vasculitis activity score (BVAS) at diagnosis. We stratified AAV patients into three groups according to the tertile of BVAS and defined the lower limit of the highest tertile as the cutoff for severe AAV (BVAS at diagnosis ≥ 16) at diagnosis. Low serum C3 level was ...
Complement 5a and its receptor C5aR (CD88) are involved in the pathogenesis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.. This is a randomized, double-blind, active-controlled Phase 3 study to evaluate the safety and efficacy of the orally-administered, selective C5aR inhibitor CCX168 (avacopan) in inducing and sustaining remission in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treated concomitantly with Rituximab or Cyclophosphamide/Azathioprine. ...
Childhood systemic vasculitides are a group of rare diseases with multi-organ involvement and potentially devastating consequences. After establishment of new classification criteria (Ankara consensus conference in 2008), it is now time to establish measures for proper definition of activity and damage in childhood primary vasculitis. By comparison to adult vasculitis, there is no consensus for indices of activity and damage assessment in childhood vasculitis. Assessment of disease activity is likely to become a major area of interest in pediatric rheumatology in the near future. After defining the classification criteria for primary systemic childhood vasculitis, the next step was to perform a validation study using the original Birmingham vasculitis activity score as well as the disease extent index to measure disease activity in childhood vasculitis. Presently, there are efforts in place to develop a pediatric vasculitis activity score. This paper reviews the current understanding about the
An elderly woman w/ history of IDA, aortic aneurysm + AI, and monoclonal gammopathy presents with SOB, found to have rapidly progressive anemia, AKI, and R,L pulmonary infiltrate concerning for a pulmonary-renal syndrome. She was ultimately diagnosed with ANCA vasculitis with +MPO, possibly related to hydralazine use and with some SLE overlap. Despite steroids and cytoxan, her renal failure progressed quickly requiring dialysis, and she ultimately transitioned to comfort care several months after the initial diagnosis ...
Results We included 857 patients (77% women), age 18-85 years, disease duration 0-58 years. Persons with SLE were younger 47(34-57) than persons with SSc 60(52-69) p,0.001 and AAV 62(49-69) p,0.001, and they had longer disease duration 10 (2-20) than both the SSc 2 (0-8) p,0.001 and the AAV 3 (0-8) p,0.001 groups.. SLE patients reported a higher anxiety level and more impact of fatigue on all analysed subscales compared to the AAV patients, and all but impact on daily activities compared to SSc. SSc and AAV had a similar pattern on all analysed components (Table 1).. Among persons with disease duration less than a year, SLE still scored highest on all components of fatigue, but interestingly AAV patients reported similar figures to SLE regarding the severity and distress of fatigue (Table 2). ...
Investigators have made a major advance in treating people with a severe form of vasculitis, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, a rare but devastating disease of blood...
Allows fully automated detection of clinically relevant antibodies (anti-MPO, anti-PR3 and anti-GBM) associated with systemic small vessel vasculitis on the BioPlex 2200 system
Reactivity: Cow (Bovine), Dog (Canine) Host: Rabbit Clone: Polyclonal 1 image 1 PubMed reference | Order NCF4 antibody (ABIN2782428).
BACKGROUND The treatment approaches to antineutrophil cytoplasmic autoantibody (ANCA) small vessel vasculitis expose patients to the risks associated with long-term use of corticosteroids and cytotoxic agents. In an effort to explore approaches to minimize risks, we conducted a pilot efficacy and safety study of mycophenolate mofetil (MMF) in the treatment of subjects with nonlife-threatening recurrent or cyclophosphamide-resistant ANCA-vasculitis. METHODS MMF was initiated at 500 mg orally twice daily and gradually increased to a target dose of 1000 mg twice daily for a duration of 24 weeks. Concomitant therapy with corticosteroids was allowed. The Birmingham Vasculitis Activity Score (BVAS) was used to assess disease activity and treatment efficacy. ANCA titres, serum creatinine and adverse events were secondary measures of efficacy and/or toxicity. RESULTS Twelve subjects were enrolled in the study. Treatment with MMF led to an improvement in disease activity as measured by the BVAS at 24 weeks
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Cutaneous small-vessel vasculitis, also known as hypersensitivity vasculitis, cutaneous leukocytoclastic vasculitis, hypersensitivity angiitis, cutaneous leukocytoclastic angiitis, cutaneous necrotizing vasculitis and cutaneous necrotizing venulitis, is inflammation of small blood vessels (usually post-capillary venules in the dermis), characterized by palpable purpura. It is the most common vasculitis seen in clinical practice. "Leukocytoclastic" refers to the damage caused by nuclear debris from infiltrating neutrophils in and around the vessels. Initially red to pink, flat spots (formally, "macules") and raised bumps (formally, "papules") may be seen on the skin. Once fully developed, the classic appearance is "non-blanching, palpable purpura". This appears as deep red to purple spots that feel raised to the touch. Purpura refers to the red-purple discolored spots, while palpable implies that these spots can be felt as raised from the surrounding skin. Additionally, when gently pressed, the ...
Background Myeloperoxidase (MPO) anti-neutrophil cytoplasm autoantibody (ANCA)-associated vasculitis commonly causes life-threatening pulmonary alveolar hemorrhage or fibrosis. autoantibodies against endothelial cell such as VCAM-1. Then VCAM-1 mediates the adhesion of lymphocytes and monocytes to vascular endothelium. 1 Anti-neutrophil cytoplasm autoantibody (ANCA)-linked illnesses are autoimmune circumstances seen as a necrotizing irritation of small arteries with considerably higher mortality prices than various other autoimmune illnesses (Jones et al. 2010 Nakaya et al. 2013 In ANCA-associated vasculitis (AAV) especially in myeloperoxidase (MPO)-particular ANCA-positive situations the clinical research have been generally centered on renal lesions (Jennette and Falk 2014 Nonetheless it has become apparent that pulmonary lesions such as for example alveolar hemorrhage or fibrosis show up concurrently to renal lesions (Zhang et al. 2014 Furthermore there is really as well as proof to recommend ...
ISBN : 9781632413819. Publisher : haylemedical. Language : English. Category : Rheumatology. Publication Year : 2015. Price : USD 124.95. Description : Latest information regarding the treatment as well as diagnosis of the disease of vasculitis has been illuminated in this profound book. Vasculitis is an inflammatory disease which affects the blood vessels. It can be idiopathic or secondary to other conditions. Infections may also resemble idiopathic vasculitis, and the differential diagnosis requires principal attention from the practicing physicians. Vasculitides are common diseases. Moreover, few vasculitides like ANCA-associated vasculitis, giant cell arteritis, and, cutaneous vasculitis are quite common in everyday practice. Vasculitis can result in failure of organs in patients and prove to be fatal. Hence, it should be diagnosed as soon as possible by physicians of varying specialties for a timely decision on appropriate treatment method. Lately, the field of pathophysiology and treatment ...
Low daily doses of oral prednisone during long-term maintenance therapy was associated with a higher rate of relapse in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in Japan, a study reports.
Dr. Ronald Falk presented the annual NIH Astute Clinician Lecture in early November in the NIH Clinical Center. Falk was introduced by Dr. Francis Collins, director of the NIH, who reflected on his experience learning alongside Falk in medical school.. "I found out during the four years of medical school Ron Falk was an exceptionally intelligent, thoughtful, hard-working, dedicated guy who was going to be undoubtedly a leading physician in the nation. And that turned out to be true," said Collins.. Falk is the chair of the Department of Medicine and a Nan and Hugh Cullman eminent professor at the University of North Carolina Chapel Hill. Through his lecture, "Perspective on Autoimmunity: A View from the ANCA Vasculitis Looking Glass," Falk discussed Anti-Neutrophil Cytoplasmic Autoantibodies (ANCA) vasculitis, a type of autoimmune swelling caused by autoantibodies. A persons immune system helps to fight germs by using normal antibodies in the blood. But some people have abnormal antibodies, ...
Churg-Strauss Syndrome (CSS) is a rare disorder associated with increased number of eosinophils in the blood, extravascular granulomas, and system small vessel vasculitis.
... is redness and swelling (inflammation) of the system of small tubes that carry blood throughout your body (vessels, arteries, veins and capillaries). This inflammation can cause these tubes to become weak and narrow, leading to a blockage which will cut off blood supply to an area of the body. Vasculitis can affect any area of the body, leading to damage of any organ or tissue.. The symptoms of vasculitis vary depending on which organ or tissue is affected. Symptoms may include a rash, muscle weakness, fever, weight loss, general fatigue, kidney failure, heart attack or stroke. Vasculitis can be diagnosed by your doctor using a combination of your health history, physical exam, blood and urine tests to look for signs of inflammation or organ damage, imaging tests (x-ray, CT or MRI) to look for inflammation and organ damage, and removal of a small piece of affected tissue (biopsy) to look for signs of vasculitis.. Treatment options depends on which tissue or organ is affected. In some ...
The V-PPRN seeks to transform how clinical research in vasculitis is conducted by directly engaging patients, investigators, care providers, and health systems to develop research methods to electronically collect health records and patient-reported data on a large number of patients with various forms of vasculitis.. The goal of the V-PPRN research program is to conduct high-quality studies that will improve the care and the health of patients with vasculitis by exploring research questions that matter most to patients and advance medical knowledge about vasculitis.. ...
Vasculitis occurs if your immune system attacks your blood vessels by mistake. What causes this to happen isnt fully known.. A recent or chronic (ongoing) infection may prompt the attack. Your body also may attack its own blood vessels in reaction to a medicine.. Sometimes an autoimmune disorder triggers vasculitis. Autoimmune disorders occur if the immune system makes antibodies (proteins) that attack and damage the bodys own tissues or cells. Examples of these disorders include lupus, rheumatoid arthritis, and scleroderma. You can have these disorders for years before developing vasculitis.. Vasculitis also may be linked to certain blood cancers, such as leukemia and lymphoma. ...
The most common glomerular disease in the ,80 age group is ANCA associated vasculitis and usually anti MPO in nature. This is now well established. A Recent paper in Kidney International retrospectively looks at treatment of this entity in this age group. Many of us would not treat given the heavy immunosuppresive burden and anticipating increase risk. The investigators in this study, looked at 78 cases that were biopsy proven ANCA vasculitis and showed that the patients with treatment with the agents had a significant lower incidence of ESRD 1 year biopsy with significant p value. No difference in terms of mortality between the two groups in one year. When followed for 2 years, the immunosuppresive group had a better advantage ...
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Sept. 23 to 29 is vasculitis awareness week. Vasculitis is inflammation of a blood vessel(s). The symptoms and complications that occur from vasculitis depend on which vessels are affected and the extent of the inflammation.
Sept. 23 to 29 is vasculitis awareness week. Vasculitis is inflammation of a blood vessel(s). The symptoms and complications that occur from vasculitis depend on which vessels are affected and the extent of the inflammation.
Sept. 23 to 29 is vasculitis awareness week. Vasculitis is inflammation of a blood vessel(s). The symptoms and complications that occur from vasculitis depend on which vessels are affected and the extent of the inflammation.
Sept. 23 to 29 is vasculitis awareness week. Vasculitis is inflammation of a blood vessel(s). The symptoms and complications that occur from vasculitis depend on which vessels are affected and the extent of the inflammation.
Sept. 23 to 29 is vasculitis awareness week. Vasculitis is inflammation of a blood vessel(s). The symptoms and complications that occur from vasculitis depend on which vessels are affected and the extent of the inflammation.
Sept. 23 to 29 is vasculitis awareness week. Vasculitis is inflammation of a blood vessel(s). The symptoms and complications that occur from vasculitis depend on which vessels are affected and the extent of the inflammation.
As part of the Vasculitis & U Day, there will be a question and answer session led by Consultant Rheumatologist Dr Chetan Mukhtyar. If anyone in the VUK community would like to ask any questions...
My husband had a biopsy when his kidney function was declining. He was in hospital at the time as the eGFR had gone down rapidly to 15. If they had done the biopsy at an earlier stage they would have discovered that he had Anca vasculitis and they might have been able to save his kidneys. As it was they tried giving him high doses of strong steroids but it was too little too late and he ended up on dialysis. I would ask if its possible for them to do a biopsy to find out exactly whats going on with your kidneys. It could be something simple or something that can be treated before it gets any worse. Dont let them put you off ...
So much to figure out. So much to remember and to trust. I used to be much better at this. All that coping with a rare chronic illness does get in the way now. Suddenly I am in a situation where the doctor produces the evidence, explains procedures in precise sentences, expertly circling shadows in the MRI printout, almost bored he stresses how often he has performed this surgery in the past. Whereas the usual scenario is that baffled questioning look. ANCA vasculitis, yes I heard of that one but never met a patient etc. And I usually provide the prompts and watch them taking notes or doing a rapid search online.. So strange being a normal patient with a common and garden sequestered disc that had to be removed from the spinal canal to release the trapped nerve and halt the advancing paralysis of my right leg.. Last night after surgery as I was lying flat on my back attached to various tubes I was unable to sleep for sheer delight that I did it and that the most awful pain was gone. I silently ...
When the immune system attacks the blood vessels by mistake, the condition is called vasculitis. There are some autoimmune disorders also that can make the immune system make antibodies that attack the bodys own tissues or cells.
Vasculitis is an inflammation of your blood vessels. Vasculitis causes changes in the walls of your blood vessels, including thickening, weakening, narrowing and scarring.
Vasculitis disease occurs due to inflammation of blood vessels. The vasculitis symptoms are characterized based on the organ that is affected.
AESKULISA® Vasculitis Test Kits Vasculitis comprises of varying diseases that have in common an inflammation of the blood vessels. For rapid and...
Related Articles Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis: unpredictable, but predictive of renal outcome. Rheumatology (Oxford). 2019 Jan 01;58(1):103-109 Authors: Wester Trejo MAC, Floßmann ...
Results Active vasculitis samples showed decreased proportions of Bm1 (7.8% vs 11%; p = 0.041), Bm2 (0.2% vs 0.7%; p = 0.002), and Bm3/Bm4 (0.1% vs 0.3%; p = 0.006), compared with controls; Bm2 cells were the most frequently occurring B cells but they were not significantly different in active vasculitis (74% vs 62%; p = 0.083). In patients with remission the proportion of CD25+ B cells was increased compared to controls (48% vs 29%, respectively; p = 0.006) and also compared to active vasculitis (23%; p = 0.006). The proportion of CD86+ B cells was also increased (31%) compared to active vasculitis (8%; p = 0.001), and to controls (6%; p = 0.0003). In multivariate analysis, Bm2 cells and CD25+27- B cells were independently influencing the patient group. ...
The vasculitis encompasses a group of diseases in which an inflammation of the blood vessels that carry blood to an organ occurs.
Undoubtedly the most severe and life-threatening of my illnesses, my trials through the affliction that is Vasculitis is still very real and present. I have tried my hardest to be regular and authentic in the last two years as I tackle the effects of this illness on my life. Yet here I am surprisingly for…
New research suggests that a newer drug works no better than an older, cheaper medication for patients who need long-term treatment for a type of vasculitis, a
Can you name the Vasculitis Test your knowledge on this science quiz to see how you do and compare your score to others. Quiz by thespazz
醫學系「免疫與感染學 V 」模組 Vasculitis 魏正宗 中山醫學大學附設醫院過敏免疫風濕科主任 Tel: 04 24729595 ext 34314; Email: [email protected]
Was retested due to positive p-anca result. Consultant requested my health centre retest after 3 months . Went, done the bloods, rang for result today to be told not done due to technical issues! Eh...
"Vasculitis" . Remedios para el síndrome de Sjógren. , sin otros trastornos asociados. El síndrome de Sjógren secundario tiene lugar junto a otros trastornos autoinmunes, como lupus eritematoso sistémico, artritis reumatoide, esclerodermia, vasculitis o polimiositis
We appreciate our colleagues comments and are glad that our analysis has stimulated further thought among clinicians. We agree with Dr. Padhan that Wegener granulomatosis may be difficult to differentiate from tuberculous infection. However, studies suggest that the presence of both positive cytoplasmic ANCA by immunofluorescence and proteinase 3 enzyme-linked immunosorbent assay has a low prevalence in tuberculosis (1). Even in those rare patients in whom the diagnosis of Wegener granulomatosis is doubted and the balance of evidence favors ANCA-associated vasculitis, we believe that patients should be treated with pulse cyclophosphamide rather than with daily oral cyclophosphamide. The cumulative dose of cyclophosphamide when administered in a pulse dose is half that of the oral regimen. For example, a person who weighs 70 kg receives a 1-g pulse of cyclophosphamide over 2 weeks compared with 2 g of the oral regimen. In persons with suspected latent tuberculosis or a history of tuberculosis, ...
Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes. They are detected as a blood test in a number of autoimmune disorders, but are particularly associated with systemic vasculitis, so called ANCA-associated vasculitides. Immunofluorescence (IF) on ethanol-fixed neutrophils is used to detect ANCA, although formalin-fixed neutrophils may be used to help differentiate ANCA patterns. ANCA can be divided into four patterns when visualised by IF; cytoplasmic ANCA (c-ANCA), C-ANCA (atypical), perinuclear ANCA (p-ANCA) and atypical ANCA (a-ANCA), also known as x-ANCA. c-ANCA shows cytoplasmic granular fluorescence with central interlobular accentuation. c-ANCA (atypical) shows cytoplasmic staining that is usually uniform and has no interlobular accentuation. p-ANCA has three subtypes, classical p-ANCA, p-ANCA without nuclear extension ...
Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of
OBJECTIVES: We report a patient with potassium channel antibody-associated non-paraneoplastic limbic encephalitis (NPLE) in whom repeated fluorodeoxyglucose-positron emission tomography (FDG-PET) and magnetic resonance imaging (MRI) are correlated with epileptic activity and memory performance during the course of disease. CASE SUMMARY: A 32-year-old woman suffered from prolonged global amnesia after two generalized tonic-clonic seizures due to NPLE. Initially, MRI showed swelling of the left hippocampus. In FDG-PET, however, bitemporomesial hypermetabolism was seen corresponding to frequent bitemporal independent seizure patterns. Also neuropsychological impairments pointed to a bitemporal involvement at this early stage. In parallel with improved control of electrographic seizure patterns, improvement was seen in FDG-PET and in memory performance. During the whole course, MRI showed only left-sided abnormalities, which correlated with a permanent verbal memory impairment. CONCLUSION: FDG-PET was more
Time courses of changes in the Birmingham vasculitis activity score (BVAS), myeloperoxidase-anti-neutrophil cytoplasmic antibodies (MPO-ANCA) titer, and serum c
CpG oligodeoxynucleotide stimulates production of anti-neutrophil cytoplasmic antibodies in ANCA associated vasculitis. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
OMERACT is an independent initiative of international rheumatology health professionals interested in the development and validation of outcome measures in rheumatic diseases. Individual OMERACT groups hold consensus conferences every two years. The ongoing work of this OMERACT group has been to employ a data-driven approach to developing a core set of domains to shape standardized outcome measures for clinical trials of large vessel vasculitis treatments.. The comprehensive review of the literature conducted by this working group several years ago demonstrated a lack of standardized outcome measures for large vessel vasculitis.2,3 No broadly accepted definitions of important outcomes, such as disease activity or response to therapy, exist, Dr. Aydin explains. She also notes randomized controlled trials conducted for treatments targeting large vessel vasculitis diseases, such as Takayasus arteritis and giant cell arteritis, have usually based definitions of relapse and remission on the presence ...
Antineutrophil Cytoplasmic Antibodies: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for WEGENER GRANULOMATOSIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.
An antineutrophil cytoplasmic antibody is a type of protein that is produced by the bodys immune system and is associated with a...
Background and objectives: Microscopic polyangiitis (MPA) is a systemic small-vessel vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCA), often targeting myeloperoxidase (MPO). Cyclophosphamide (CYC) plus corticosteroids (CS) is considered standard therapy for patients with renal involvement, but treatment response is not satisfactory in all patients and CYC has well recognized toxicity. This prospective pilot trial explored whether mycophenolate mofetil (MMF) represents an effective alternative to CYC for induction and maintenance of remission in MPA with mild to moderate renal involvement.. Design, setting, participants, & measurements: Seventeen P-ANCA/MPO-ANCA-positive patients with MPA with mild to moderate renal involvement received MMF (1000 mg orally, twice daily) and CS (intravenous methylprednisolone, 1 to 3 g, followed by oral prednisone at 1 mg/kg per day). Oral CS were discontinued by month 6; MMF was continued through month 18. The primary outcome measure was ...
The Vasculitis Foundation is a membership-based organization and partners with patients, family members, friends, medical professionals and the international research community to advocate for early diagnosis, leading edge treatment and ultimately a cure for all types of vasculitis. Join Today!. Membership in the Vasculitis Foundation means that you are committed to the vasculitis community - to learning all the latest information about vasculitis, to supporting vasculitis research, to encouraging vasculitis patients and their family members, and participating in advocacy efforts led by the Vasculitis Foundation. Your membership shows your commitment to raising awareness about vasculitis and the Vasculitis Foundation.. ...
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Vasculitis is a term for a group of rare diseases that have in common inflammation of blood vessels. These vessels include arteries and veins. There are many types of vasculitis, and they may vary greatly in symptoms, severity and duration. Most types of vasculitis are rare, and the causes are generally not known. Vasculitis affects persons of both sexes and all ages. A few forms of vasculitis affect certain groups of people. For instance, Kawasaki disease occurs only in children. IgA Vasculitis (Henoch-Schönlein) is much more common in children than adults. On the other hand, giant cell arteritis occurs only in adults over 50 years old.. Vasculitis can result in poor blood flow to tissues throughout the body, such as the lungs, nerves and skin. Thus, vasculitis has a wide range of signs and symptoms (what you see and feel), such as:. ...
Interestingly, Aevm2 in an MRL allele, which governed susceptibility to vasculitis in the lower limbs with significant linkage, also showed a weak association with vasculitis in aortic branches (with a suggestive linkage in QTL analysis [LOD score 2.2]). Thus, it seems that Aevm2 might be a susceptibility locus common to vasculitis both in lower limbs and in aortic branches, although it may dominantly affect vasculitis in lower limbs. Moreover, it is worth noting that Aaom1 (13.3 cM) and Arvm1 (19.8 cM), which are the susceptibility loci to vasculitis in aortic branches and kidneys, respectively, are located close to one another on chromosome 4. This might suggest that development of vasculitis in these tissues is closely associated. However, the number of F2 mice tested in this study (n = 266) is insufficient to evaluate the statistical difference between genotype and phenotype overlap of vasculitis in each combination of tissue distribution.. We also found sex differences in the vasculitis ...
Free resource for searching and exporting immune epitopes. Includes more than 95% of all published infectious disease, allergy, autoimmune, and transplant epitope data.
Glomerulonephritis and small vessel vasculitis caused by antl-neutrophil cytoplasmic autoantibodies (ANCA) is the most common cause for rapidly progressive glom...
Wegeners granulomatosis (WG), microscopic polyangiitis (MPA) and Churg- Strauss syndrome (CSS) are small to medium-vessel vasculitides that, because of their frequent association with antineutrophil cytoplasmic antibodies (ANCA), are usually referred to as ANCA-associated systemic vasculitides (AASV). These diseases are challenging to diagnose and to treat. The diagnosis of AASV is made on the basis of clinical findings, biopsy of the involved organ and the presence of ANCA in the serum. Lung disease is a very common and important clinical feature of AASV.. Vasculitis in the lung usually involves the small vessels -arteries, capillaries and venules. Distinguishing the ANCA-associated vasculitides from other forms of vasculitis or nonvasculitic processes (such as infection) can be particularly difficult. ANCA are associated with small sized vessel vasculitis ; one subtype is an antibody against myeloperoxidase (MPO), which stains in a perinuclear pattern (P-ANCA) indirect immunofluorescence ...
Looking for online definition of Cytoplasmic Antineutrophil Cytoplasmic Antibody in the Medical Dictionary? Cytoplasmic Antineutrophil Cytoplasmic Antibody explanation free. What is Cytoplasmic Antineutrophil Cytoplasmic Antibody? Meaning of Cytoplasmic Antineutrophil Cytoplasmic Antibody medical term. What does Cytoplasmic Antineutrophil Cytoplasmic Antibody mean?
Although a new classification algorithm for systemic vasculitides was proposed by Watts et al. and the Chapel Hill Consensus Conference (CHCC) was updated in 2012, there are currently no validated diagnostic criteria for systemic vasculitides. The Diagnostic and Classification Criteria for Vasculitis study (DCVAS) is a global study to develop and improve the diagnostic criteria for systemic vasculitides. The epidemiology of systemic vasculitides differs widely among countries. For example, in the case of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, patients with microscopic polyangiitis (MPA) and with positivity for MPO-ANCA are predominant in Asian countries, whereas patients with granulomatosis with polyangiitis (GPA) and with positivity for PR3-ANCA are predominant in northern Europe and the United States ...
AIMS--To study the effect of proctocolectomy on the antineutrophil cytoplasmic antibody (ANCA) titres in association with ulcerative colitis. METHODS--Serum samples were taken from 15 patients with ulcerative colitis immediately before and at a mean of 24 months after proctocolectomy. Indirect immunofluorescence for ANCA and enzyme immunoassays for myeloperoxidase and proteinase-3 antibodies were employed. A liver biopsy was taken from every patient during the proctocolectomy, and serum liver enzyme activities were also determined. RESULTS--Before proctocolectomy, 13 of the 15 patients had perinuclear antineutrophil cytoplasmic antibodies (p-ANCA). Additionally, one patient had a low tire of classical cytoplasmic ANCA and one had granulocyte specific antinuclear antibodies. After proctocolectomy, the ANCA titres decreased in 10 patients, in two of whom they became negative. The titres remained the same in four patients with positive ANCA and increased twofold in one patient. Only one patient was ...
The Vasculitis Service at CUH treats patients with all forms of systemic vasculitis, including ANCA-associated small vessel vasculitis (Granulomatosis with polyangiitis (formerly called Wegeners granulomatosis), microscopic polyangiitis and polyarteritis nodosa), Churg-Strauss syndrome and Takayasus arteritis.. Our multi-disciplinary team includes Physicians in Renal Medicine, Rheumatology, Respiratory Medicine, Immunology and Neurology working in collaboration with colleagues in ENT Surgery and Histopathology to diagnose patients and manage these complex diseases.. The Vasculitis Service participates in research on new treatments and diagnostic techniques in vasculitis. We work together with other colleagues interested in the field within Ireland and in Europe and are major contributors to Irish Rare Kidney Disease Biobank and Registry of the Vasculitis Rare Disease Working Group of the UK and Ireland.. We operate a dedicated multi-disciplinary clinic for patients with vasculitis.. Referrals ...

Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody...Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody...

Renal failure is also uncommon as an adverse event of anti-epidermal growth factor receptor antibody. A 67-year-old Japanese ... However, there are few reports of purpura induced by anti-epidermal growth factor receptor antibody. ... A skin biopsy was performed to evaluate the purpuric lesions on his left leg and leukocytoclastic vasculitis was diagnosed. ... This is the first reported case of leukocytoclastic vasculitis followed by purpura and acute renal failure associated with ...
more infohttps://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-018-1877-7

Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisNasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

... Yusho Ishii, ... "Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis," Case Reports ...
more infohttps://www.hindawi.com/journals/crirh/2018/8192021/cta/

Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - ONAWegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - ONA

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis. *Serum HPV Antibody Levels May Be a Biomarker for ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
more infohttp://www.oncologynurseadvisor.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592194/

Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis. *Churg Strauss vasculitis (Churg Strauss granulomatosis ( ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
more infohttp://www.psychiatryadvisor.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592195/

Evidence | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...Evidence | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...

... with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis ... Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis. ...
more infohttps://www.nice.org.uk/guidance/ta308/evidence

Overview | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...Overview | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...

... with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis ... Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis. ... with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis in adults. ...
more infohttps://www.nice.org.uk/guidance/ta308?UNLID=13594526120202179250

Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Renal and Urology NewsWegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Renal and Urology News

Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... Short-Course Rituximab Produces Long-Term Remissions of ANCA Vasculitis. *Anti-Neutrophils Cytoplasmic Antibodies (ANCA) ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
more infohttps://www.renalandurologynews.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592193/

Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitisMarkers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis

ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by ... Fatigue (OR 7.1, 95% CI 1.5, 33.1), depression (OR 4.4, 95% CI 1.8, 10.8), severe disease damage [Vasculitis Damage Index (VDI ...
more infohttps://insights.ovid.com/rheml/201405000/00126062-201405000-00029

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017

ANCA Vasculitis) Global Clinical Trials Review, H1, 2017 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA ... Vasculitis) Global Clinical Trials Review, H1, 2017 Summary GlobalDatas clinical - Market research report and industry ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017. Summary. ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017. Lowest ...
more infohttps://www.marketresearch.com/GlobalData-v3648/Anti-Neutrophil-Cytoplasmic-Antibody-Associated-10860479/

Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...

Clinical trial for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Microscopic Polyangiitis , Wegeners ... ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis is characterised by small vessel vasculitis and presence of ... Low-dose Glucocorticoid Vasculitis Induction Study Brief description of study. Previous reports suggested conventional ... B cell depletion therapy by rituximab is a new strategy for remission induction in ANCA-associated vasculitis. The RAVE and ...
more infohttps://www.centerwatch.com/clinical-trials/listings/173745/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-low-dose-glucocorticoid-vasculitis-induction/?geo_lat=35.4437078&geo_lng=139.6380256&radius=10

Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...

Clinical trial for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Microscopic Polyangiitis , Wegeners ... ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis is characterised by small vessel vasculitis and presence of ... Low-dose Glucocorticoid Vasculitis Induction Study Brief description of study. Previous reports suggested conventional ... B cell depletion therapy by rituximab is a new strategy for remission induction in ANCA-associated vasculitis. The RAVE and ...
more infohttps://www.centerwatch.com/clinical-trials/listings/173745/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-low-dose-glucocorticoid-vasculitis-induction/?geo_lat=43.0620958&geo_lng=141.3543763&radius=10

Purchase: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, 2018Purchase: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, 2018

Report Name : Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, 2018 ...
more infohttps://www.reportsnreports.com/purchase.aspx?name=1810263

Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster...Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster...

Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster ... Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster ...
more infohttps://ard.bmj.com/content/72/6/1003.responses

Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type | Annals...Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type | Annals...

Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type ... Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type ... Objective To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated ... vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO) antibodies) predicts treatment ...
more infohttp://ard.bmj.com/content/early/2015/11/30/annrheumdis-2015-208073.full

Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 -...Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 -...

Your ticket for the: Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ...
more infohttps://www.vasculitisfoundation.org/feed-items/clinical-trials-on-global-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-anca-vasculitis-market-h2-2018-fashion-herald/

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and...Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and...

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and ... and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We sought to define pharmacodynamic biomarkers of ... Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and ... For AAV, 8 of 11 biomarkers of the anti-inflammatory response to glucocorticoids were validated (P-value more infohttps://www.luriechildrens.org/en/research/publications/serum-biomarkers-of-glucocorticoid-response-and-safety-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-and-juvenile-dermatomyositis/

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated VasculitisAnti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis

Anti-neutrophils cytoplasmic antibodies (ANCA) are associated with a group of necrotizing small vessel vasculitides that ... Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis LabMed. Anti-Neutrophils Cytoplasmic Antibodies (ANCA) ... Exclusion tests may include complement C3 and C4, anti-GBM, ANA, anti-dsDNA, anti-Sm/RNP, and anti-SSA/SSB. ... because anti-nuclear antibodies (ANA) may produce similar staining patterns on neutrophil nuclei. A P-ANCA pattern should not ...
more infohttp://www.infectiousdiseaseadvisor.com/labmed/anti-neutrophils-cytoplasmic-antibodies-anca-associated-vasculitis/article/614958/

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated VasculitisAnti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis

Anti-neutrophils cytoplasmic antibodies (ANCA) are associated with a group of necrotizing small vessel vasculitides that ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). *Survival in SLE-Related Pulmonary ... Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis LabMed. Anti-Neutrophils Cytoplasmic Antibodies (ANCA) ... Exclusion tests may include complement C3 and C4, anti-GBM, ANA, anti-dsDNA, anti-Sm/RNP, and anti-SSA/SSB. ...
more infohttps://www.thecardiologyadvisor.com/labmed/anti-neutrophils-cytoplasmic-antibodies-anca-associated-vasculitis/article/614959/

Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 -...Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 -...

Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ...
more infohttps://www.vasculitisfoundation.org/feed-items/global-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-anca-vasculitis-clinical-trials-review-h2-2018-researchandmarkets-com-tullahoma-news-and-guardian/

Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a...Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a...

Background Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical ... Anti-neutrophil cytoplasmic autoantibody pathogenicity revisited: pathogenic versus non-pathogenic anti-neutrophil cytoplasmic ... ANCA anti-neutrophil cytoplasmic antibody, BVAS Birmingham Vasculitis Activity Score, EGPA eosinophilic granulomatosis with ... Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a ...
more infohttps://rd.springer.com/article/10.1186/s12891-015-0796-7

Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Neurology AdvisorWegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Neurology Advisor

Close more info about Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) ... Close more info about Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
more infohttps://www.neurologyadvisor.com/decision-support-in-medicine/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/

Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated...Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated...

... induction of anti-neutrophil cytoplasmic antibody (ANCA), to the hosts. Since ANCA can induce NET formation in the primed ... which are extruded from activated neutrophils. Although NETs are essential in innate immunity, an excessive formation of NETs ... neutrophils, a positive feedback loop can be formed between NETs and ANCA, which is called ... Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), ...
more infohttps://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-018-0953-y

Anti-neutrophil cytoplasmic antibody-associated vasculitis Pathway Map - PrimePCR | Life Science | Bio-RadAnti-neutrophil cytoplasmic antibody-associated vasculitis Pathway Map - PrimePCR | Life Science | Bio-Rad

Anti-neutrophil cytoplasmic antibody-associated vasculitis H96. Anti-neutrophil cytoplasmic antibody-associated vasculitis H384 ... Anti-neutrophil cytoplasmic antibody-associated vasculitis M96. Anti-neutrophil cytoplasmic antibody-associated vasculitis M384 ... Anti-neutrophil cytoplasmic antibody-associated vasculitis. print Email " style="padding-top:-15px;"> ... Anti-neutrophil cytoplasmic antibody-associated vasculitis H96 Predesigned 96-well panel for use with SYBR® Green ...
more infohttps://www.bio-rad.com/en-us/prime-pcr-assays/pathway/cardiovascular-diseases/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis

Severe Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic...Severe Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic...

Pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: the influence of ANCA subtype ... Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic Antibodies (PR3 ... Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associate vasculitis ... and anti-MPO 0U/ml. Other studies, which included anti-glomerular basement membrane antibodies, ANA, complement, ...
more infohttp://archbronconeumol.org/en-severe-pulmonary-emphysema-in-young-articulo-S1579212918301496

Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis. *Churg Strauss vasculitis (Churg Strauss granulomatosis ( ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...
more infohttps://www.endocrinologyadvisor.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592196/
  • Panitumumab is the first human combinatorial antibody for the treatment of metastatic colorectal carcinoma. (biomedcentral.com)
  • Panitumumab is a fully humanized antibody for the treatment of RAS wild-type metastatic colorectal carcinoma (mCRC). (biomedcentral.com)
  • In vitro studies have found that ANCAs can activate neutrophils, increase their adherence to endothelium, and induce their degranulation that can damage endothelial cells. (wikipedia.org)
  • It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs. (wikipedia.org)
  • These vasculitides affect arterioles, capillaries, and venules which can involve virtually any organ with varying degrees of severity. (radiopaedia.org)
  • NET induction activity was high in Sera A, B, and C but not in D. Additionally, we demonstrated the presence of anti-NET antibody (ANETA) in Sera B and C but not in A or D. (biomedcentral.com)
  • 2) hydralazine-induced reversal of epigenic silencing of MPO and proteinase3 (PR3) leading to increased expression of neutrophil autoantigens and (3) a break in tolerance in slow versus fast acetylators of hydralazine. (bmj.com)
  • Other more recent reports of widespread livedo and acral purpura due to vascular coagulation similar to that seen in livedoid vasculitis but with a much more rapid, widespread and intense onset have been linked to cocaine laced with levamasole. (oncologynurseadvisor.com)
  • The identified efficacy biomarkers may be useful as objective outcome measures for early phase proof-of-concept studies when assessing novel anti-inflammatory drugs in JDM and AAV, and likely in other inflammatory disorders. (luriechildrens.org)