Anti neutrophil cytoplasmic antibody associated vasculitis. Medical search

Antibodies, Antineutrophil Cytoplasmic: Autoantibodies directed against cytoplasmic constituents of POLYMORPHONUCLEAR LEUKOCYTES and/or MONOCYTES. They are used as specific markers for GRANULOMATOSIS WITH POLYANGIITIS and other diseases, though their pathophysiological role is not clear. ANCA are routinely detected by indirect immunofluorescence with three different patterns: c-ANCA (cytoplasmic), p-ANCA (perinuclear), and atypical ANCA.Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Myeloblastin: A polymorphonuclear leukocyte-derived serine protease that degrades proteins such as ELASTIN; FIBRONECTIN; LAMININ; VITRONECTIN; and COLLAGEN. It is named for its ability to control myeloid cell growth and differentiation.Wegener Granulomatosis: A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: Group of systemic vasculitis with a strong association with ANCA. The disorders are characterized by necrotizing inflammation of small and medium size vessels, with little or no immune-complex deposits in vessel walls.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.Microscopic Polyangiitis: A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.Churg-Strauss Syndrome: Widespread necrotizing angiitis with granulomas. Pulmonary involvement is frequent. Asthma or other respiratory infection may precede evidence of vasculitis. Eosinophilia and lung involvement differentiate this disease from POLYARTERITIS NODOSA.Polyarteritis Nodosa: A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.Systemic Vasculitis: A heterogeneous group of diseases characterized by inflammation and necrosis of the blood vessel walls.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Retinal Vasculitis: Inflammation of the retinal vasculature with various causes including infectious disease; LUPUS ERYTHEMATOSUS, SYSTEMIC; MULTIPLE SCLEROSIS; BEHCET SYNDROME; and CHORIORETINITIS.Vasculitis, Central Nervous System: Inflammation of blood vessels within the central nervous system. Primary vasculitis is usually caused by autoimmune or idiopathic factors, while secondary vasculitis is caused by existing disease process. Clinical manifestations are highly variable but include HEADACHE; SEIZURES; behavioral alterations; INTRACRANIAL HEMORRHAGES; TRANSIENT ISCHEMIC ATTACK; and BRAIN INFARCTION. (From Adams et al., Principles of Neurology, 6th ed, pp856-61)Vasculitis, Leukocytoclastic, Cutaneous: Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Glomerulonephritis: Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.Fluorescent Antibody Technique, Indirect: A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Propylthiouracil: A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534)Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Antithyroid Agents: Agents that are used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.Neutrophil Infiltration: The diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Arteritis: INFLAMMATION of any ARTERIES.Cathepsin G: A serine protease found in the azurophil granules of NEUTROPHILS. It has an enzyme specificity similar to that of chymotrypsin C.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Antibodies, Neutralizing: Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Endocarditis, Subacute Bacterial: ENDOCARDIUM infection that is usually caused by STREPTOCOCCUS. Subacute infective endocarditis evolves over weeks and months with modest toxicity and rare metastatic infection.Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.Purpura, Schoenlein-Henoch: A systemic non-thrombocytopenic purpura caused by HYPERSENSITIVITY VASCULITIS and deposition of IGA-containing IMMUNE COMPLEXES within the blood vessels throughout the body, including those in the kidney (KIDNEY GLOMERULUS). Clinical symptoms include URTICARIA; ERYTHEMA; ARTHRITIS; GASTROINTESTINAL HEMORRHAGE; and renal involvement. Most cases are seen in children after acute upper respiratory infections.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Lactoferrin: An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.Antibody Affinity: A measure of the binding strength between antibody and a simple hapten or antigen determinant. It depends on the closeness of stereochemical fit between antibody combining sites and antigen determinants, on the size of the area of contact between them, and on the distribution of charged and hydrophobic groups. It includes the concept of "avidity," which refers to the strength of the antigen-antibody bond after formation of reversible complexes.Antibodies, Fungal: Immunoglobulins produced in a response to FUNGAL ANTIGENS.N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.Epitopes: Sites on an antigen that interact with specific antibodies.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Rheumatoid Vasculitis: Necrotizing VASCULITIS of small and medium size vessels, developing as a complication in RHEUMATOID ARTHRITIS patients. It is characterized by peripheral vascular lesions, cutaneous ULCERS, peripheral GANGRENE, and MONONEURITIS MULTIPLEX.Nose Diseases: Disorders of the nose, general or unspecified.Plasma Exchange: Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Leukocyte Elastase: An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Antibodies, Monoclonal, Murine-Derived: Antibodies obtained from a single clone of cells grown in mice or rats.Binding Sites, Antibody: Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES.) They are formed from parts of the variable regions of FAB FRAGMENTS.Hemoptysis: Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.Lung Diseases: Pathological processes involving any part of the LUNG.Chemotaxis, Leukocyte: The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.Methimazole: A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.Neutrophil Activation: The process in which the neutrophil is stimulated by diverse substances, resulting in degranulation and/or generation of reactive oxygen products, and culminating in the destruction of invading pathogens. The stimulatory substances, including opsonized particles, immune complexes, and chemotactic factors, bind to specific cell-surface receptors on the neutrophil.Lysosomal-Associated Membrane Protein 2: An abundant lysosomal-associated membrane protein that has been found to shuttle between LYSOSOMES; ENDOSOMES; and the PLASMA MEMBRANE. Loss of expression of lysosomal-associated membrane protein 2 is associated with GLYCOGEN STORAGE DISEASE TYPE IIB.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Cryoglobulinemia: A condition characterized by the presence of abnormal quantities of CRYOGLOBULINS in the blood. Upon cold exposure, these abnormal proteins precipitate into the microvasculature leading to restricted blood flow in the exposed areas.HIV Antibodies: Antibodies reactive with HIV ANTIGENS.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Scleritis: Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.Immunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Graves Disease: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).Antibodies, Neoplasm: Immunoglobulins induced by antigens specific for tumors other than the normally occurring HISTOCOMPATIBILITY ANTIGENS.Anti-Glomerular Basement Membrane Disease: An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.Antibodies, Protozoan: Immunoglobulins produced in a response to PROTOZOAN ANTIGENS.Fixatives: Agents employed in the preparation of histologic or pathologic specimens for the purpose of maintaining the existing form and structure of all of the constituent elements. Great numbers of different agents are used; some are also decalcifying and hardening agents. They must quickly kill and coagulate living tissue.Eosinophilia-Myalgia Syndrome: A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Cathepsins: A group of lysosomal proteinases or endopeptidases found in aqueous extracts of a variety of animal tissues. They function optimally within an acidic pH range. The cathepsins occur as a variety of enzyme subtypes including SERINE PROTEASES; ASPARTIC PROTEINASES; and CYSTEINE PROTEASES.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Mice, Inbred BALB C Levamisole: An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Bronchiectasis: Persistent abnormal dilatation of the bronchi.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Antigens, CD18: Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Hemorrhage: Bleeding or escape of blood from a vessel.Proctocolectomy, Restorative: A surgical procedure involving the excision of the COLON and RECTUM and the formation of an ILEOANAL RESERVOIR (pouch). In patients with intestinal diseases, such as ulcerative colitis, this procedure avoids the need for an OSTOMY by allowing for transanal defecation.Recurrence: The return of a sign, symptom, or disease after a remission.Drug Contamination: The presence of organisms, or any foreign material that makes a drug preparation impure.Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.Immunologic Factors: Biologically active substances whose activities affect or play a role in the functioning of the immune system.Necrosis: The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Cell Adhesion: Adherence of cells to surfaces or to other cells.Mucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.Superoxides: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Granulocytes: Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Tissue Fixation: The technique of using FIXATIVES in the preparation of cytologic, histologic, or pathologic specimens for the purpose of maintaining the existing form and structure of all the constituent elements.Hepatitis, Autoimmune: A chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES.Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.Cytoplasm: The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)Antimicrobial Cationic Peptides: Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.Chemotactic Factors: Chemical substances that attract or repel cells. The concept denotes especially those factors released as a result of tissue injury, microbial invasion, or immunologic activity, that attract LEUKOCYTES; MACROPHAGES; or other cells to the site of infection or insult.Respiratory Burst: A large increase in oxygen uptake by neutrophils and most types of tissue macrophages through activation of an NADPH-cytochrome b-dependent oxidase that reduces oxygen to a superoxide. Individuals with an inherited defect in which the oxidase that reduces oxygen to superoxide is decreased or absent (GRANULOMATOUS DISEASE, CHRONIC) often die as a result of recurrent bacterial infections.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antigen-Antibody Reactions: The processes triggered by interactions of ANTIBODIES with their ANTIGENS.Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.Macrophage-1 Antigen: An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN. The antigen, which is an integrin, functions both as a receptor for complement 3 and in cell-cell and cell-substrate adhesive interactions.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Neutralization Tests: The measurement of infection-blocking titer of ANTISERA by testing a series of dilutions for a given virus-antiserum interaction end-point, which is generally the dilution at which tissue cultures inoculated with the serum-virus mixtures demonstrate cytopathology (CPE) or the dilution at which 50% of test animals injected with serum-virus mixtures show infectivity (ID50) or die (LD50).Leukocyte Count: The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.Adrenal Cortex Hormones Antibodies, Blocking: Antibodies that inhibit the reaction between ANTIGEN and other antibodies or sensitized T-LYMPHOCYTES (e.g., antibodies of the IMMUNOGLOBULIN G class that compete with IGE antibodies for antigen, thereby blocking an allergic response). Blocking antibodies that bind tumors and prevent destruction of tumor cells by CYTOTOXIC T-LYMPHOCYTES have also been called enhancing antibodies. (Rosen et al., Dictionary of Immunology, 1989)Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Antibodies, Bispecific: Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.Cryoglobulins: Abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when SERUM is cooled below 37 degrees Celsius. It is characteristic of CRYOGLOBULINEMIA.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Syndrome: A characteristic symptom complex.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Formaldehyde: A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)Pancreatic Elastase: A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.Single-Chain Antibodies: A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Immune Sera: Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Pulmonary Alveoli: Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.Leukotriene B4: The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)Purpura: Purplish or brownish red discoloration, easily visible through the epidermis, caused by hemorrhage into the tissues. When the size of the discolorization is >2-3 cm it is generally called Ecchymoses (ECCHYMOSIS).Giant Cell Arteritis: A systemic autoimmune disorder that typically affects medium and large ARTERIES, usually leading to occlusive granulomatous vasculitis with transmural infiltrate containing multinucleated GIANT CELLS. The TEMPORAL ARTERY is commonly involved. This disorder appears primarily in people over the age of 50. Symptoms include FEVER; FATIGUE; HEADACHE; visual impairment; pain in the jaw and tongue; and aggravation of pain by cold temperatures. (From Adams et al., Principles of Neurology, 6th ed)Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Antibodies, Heterophile: Antibodies elicited in a different species from which the antigen originated. These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification.Antibodies, Catalytic: Antibodies that can catalyze a wide variety of chemical reactions. They are characterized by high substrate specificity and share many mechanistic features with enzymes.Epitope Mapping: Methods used for studying the interactions of antibodies with specific regions of protein antigens. Important applications of epitope mapping are found within the area of immunochemistry.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Leukocytes: White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).Complement System Proteins: Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).Kinetics: The rate dynamics in chemical or physical systems.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Antibodies, Antiphospholipid: Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Takayasu Arteritis: A chronic inflammatory process that affects the AORTA and its primary branches, such as the brachiocephalic artery (BRACHIOCEPHALIC TRUNK) and CAROTID ARTERIES. It results in progressive arterial stenosis, occlusion, and aneurysm formation. The pulse in the arm is hard to detect. Patients with aortitis syndrome often exhibit retinopathy.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Arthus Reaction: A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.Antigens: Substances that are recognized by the immune system and induce an immune reaction.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Complement C5a: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.Cytoplasmic Granules: Condensed areas of cellular material that may be bounded by a membrane.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Molecular Weight: The sum of the weight of all the atoms in a molecule.Plasmapheresis: Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.Hybridomas: Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.Zymosan Chemokine CXCL1: A CXC chemokine with specificity for CXCR2 RECEPTORS. It has growth factor activities and is implicated as a oncogenic factor in several tumor types.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Receptors, Interleukin-8B: High-affinity G-protein-coupled receptors for INTERLEUKIN-8 present on NEUTROPHILS; MONOCYTES; and T-LYMPHOCYTES. These receptors also bind several other CXC CHEMOKINES.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Cell Degranulation: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.

Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts. (1/99)

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Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors. (2/99)

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CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis. (3/99)

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Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: a matched-pair cohort study. (4/99)

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Small vessel vasculitis. (5/99)

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Spontaneous resolution of delayed onset large subclavian artery pseudoaneurysm. (6/99)

A 70-year-old woman with a history of end-stage renal disease secondary to anti-neutrophil cytoplasmic autoantibody-associated vasculitis had been receiving hemodialysis for 5 years. The patient underwent attempted right internal jugular vein cannulation for temporary hemodialysis catheter placement. Pulsating mass developed in the neck and angiography revealed a subclavian artery pseudoaneurysm 4 days later. The pseudoaneurysm disappeared spontaneously during the interval between the diagnosis and the planned surgical procedure. Such delayed onset and spontaneous resolution of subclavian artery pseudoaneurysm is uncommon. Close observation may be optimal if delayed onset of pseudoaneurysm occurs after small needle puncture with cessation of antiplatelet/anticoagulant administration. (+info)

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (7/99)

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Prediction of ESRD in pauci-immune necrotizing glomerulonephritis: quantitative histomorphometric assessment and serum creatinine. (8/99)

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Eosinophilic granulomatosis with polyangiitis

Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody-associated vasculitis: a ... and antineutrophil cytoplasmic antibodies (ANCA) against neutrophil granulocytes. The American College of Rheumatology 1990 ... The third stage consists of vasculitis, which can eventually lead to cell death and can be life-threatening. This condition is ... It is a type of systemic necrotizing vasculitis. Effective treatment of EGPA requires suppression of the immune system with ...

Anti-neutrophil cytoplasmic antibody

Stegeman, CA (Nov 2005). "Predictive value of antineutrophil cytoplasmic antibodies in small-vessel vasculitis: is the glass ... Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the ... images of pANCA and cANCA fluorescence images of ANCA Anti-Neutrophil Cytoplasmic Antibody at the US National Library of ... Jennette, JC; Xiao, H; Falk, RJ (May 2006). "Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies". ...

Granulomatosis with polyangiitis

Determination of Anti-neutrophil cytoplasmic antibodies (ANCAs) can aid in the diagnosis, but positivity is not conclusive and ... Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a ... It is now widely presumed that the anti-neutrophil cytoplasmic antibodies (ANCAs) are responsible for the inflammation in GPA. ... "The antineutrophil cytoplasmic antibody-associated vasculitides". Am. J. Med. 117 (1): 39-50. doi:10.1016/j.amjmed.2004.02.030 ...

P-ANCA

... , or MPO-ANCA, or Perinuclear Anti-Neutrophil Cytoplasmic Antibodies, are antibodies that stain the material around the ... These include lactoferrin; elastase; and cathepsin G. When the condition is a vasculitis, the target is usually MPO. However, ... They are a special class of Anti-Neutrophil Cytoplasmic Antibodies. This pattern occurs because the vast majority of the ... Focal necrotizing and crescentic glomerulonephritis Rheumatoid arthritis C-ANCA Anti-Neutrophil Cytoplasmic Antibody (ANCA) ...

Necrotizing vasculitis

Bosch X, Guilabert A, Espinosa G, Mirapeix E (2007). "Treatment of antineutrophil cytoplasmic antibody associated vasculitis: a ... drug in relation to symptoms palpable purpura maculopapular rash skin biopsy showing neutrophils around vessel IgA vasculitis ( ... A systematic review of antineutrophil cytoplasmic antibody (ANCA) positive vasculitis identified best treatments depending on ... but not most other vasculitides. Antineutrophil cytoplasmic antibody (ANCA) may highly suggest granulomatosis with polyangiitis ...

Myeloperoxidase

Antibodies are also known as anti-neutrophil cytoplasmic antibodies (ANCAs), though ANCAs have also been detected in staining ... "Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis". Current Opinion in ... Antibodies against MPO have been implicated in various types of vasculitis, most prominently three clinically and ... Neutrophil verdoperoxidase has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and ...

Microscopic polyangiitis

October 2002). "Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis ... Then, the large number of antibodies make it more likely that they will bind a neutrophil. Once bound, the neutrophil ... An important diagnostic test is the presence of perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) with myeloperoxidase ... Most recently, two different groups of investigators have demonstrated that anti-MPO antibodies alone can cause necrotizing and ...

Rapidly progressive glomerulonephritis

... and type III and idiopathic RPGN are frequently associated with anti-neutrophil cytoplasmic antibodies (ANCA)-positive serum. ... the systemic disease is an ANCA-associated vasculitis such as granulomatosis with polyangiitis, microscopic polyangiitis or ... antineutrophil cytoplasmic antibodies specificity is determined via (ELISA), with pANCA(antibody) directed against MPO Serum ... The presence of anti-Glomerular basement membrane (GBM) antibodies suggests type I RPGN; antinuclear antibodies (ANA) may ...

Ronald J. Falk

"Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and ... March 2012). "Anti-LAMP-2 antibodies are not prevalent in patients with antineutrophil cytoplasmic autoantibody ... Falk, RJ; Terrell, RS; Charles, LA; Jennette, JC (June 1990). "Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to ... As an investigator, Falk studies kidney diseases caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs), which are a ...

Hypereosinophilia

Zhang J, Zhang HY, Chen SZ, Huang JY (2016). "Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and ... eosinophilic vasculitis, and eosinophilic ulcer of the oral mucosa. Other examples of organ-restricted hepereosinophilia ... Afflicted tissues exhibit acute inflammation involving eosinophils, neutrophils, monocytes, lymphocytes, and plasma cells. The ... elevated blood levels of IgM antibodies, and clonal expansion of T cells. Similar to lymphocyte=variant hypereosinophilia, the ...

Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody...

Renal failure is also uncommon as an adverse event of anti-epidermal growth factor receptor antibody. A 67-year-old Japanese ... However, there are few reports of purpura induced by anti-epidermal growth factor receptor antibody. ... A skin biopsy was performed to evaluate the purpuric lesions on his left leg and leukocytoclastic vasculitis was diagnosed. ... This is the first reported case of leukocytoclastic vasculitis followed by purpura and acute renal failure associated with ...

https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-018-1877-7

Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

... Yusho Ishii, ... "Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis," Case Reports ...

https://www.hindawi.com/journals/crirh/2018/8192021/cta/

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - ONA

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis. *Serum HPV Antibody Levels May Be a Biomarker for ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...

http://www.oncologynurseadvisor.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592194/

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis. *Churg Strauss vasculitis (Churg Strauss granulomatosis ( ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...

http://www.psychiatryadvisor.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592195/

Evidence | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...

https://www.nice.org.uk/guidance/ta308/evidence

Overview | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...

... with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis ... Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis. ... with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis in adults. ...

https://www.nice.org.uk/guidance/ta308?UNLID=13594526120202179250

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Renal and Urology News

Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). Are You Confident of the Diagnosis ... Short-Course Rituximab Produces Long-Term Remissions of ANCA Vasculitis. *Anti-Neutrophils Cytoplasmic Antibodies (ANCA) ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...

https://www.renalandurologynews.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592193/

Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis

ANCA-associated vasculitis (AAV) commonly affects those of working age. Since survival rates have been transformed by ... Fatigue (OR 7.1, 95% CI 1.5, 33.1), depression (OR 4.4, 95% CI 1.8, 10.8), severe disease damage [Vasculitis Damage Index (VDI ...

https://insights.ovid.com/rheml/201405000/00126062-201405000-00029

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017

ANCA Vasculitis) Global Clinical Trials Review, H1, 2017 Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA ... Vasculitis) Global Clinical Trials Review, H1, 2017 Summary GlobalDatas clinical - Market research report and industry ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017. Summary. ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017. Lowest ...

https://www.marketresearch.com/GlobalData-v3648/Anti-Neutrophil-Cytoplasmic-Antibody-Associated-10860479/

Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...

Clinical trial for Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Microscopic Polyangiitis , Wegeners ... ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis is characterised by small vessel vasculitis and presence of ... Low-dose Glucocorticoid Vasculitis Induction Study Brief description of study. Previous reports suggested conventional ... B cell depletion therapy by rituximab is a new strategy for remission induction in ANCA-associated vasculitis. The RAVE and ...

https://www.centerwatch.com/clinical-trials/listings/173745/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-low-dose-glucocorticoid-vasculitis-induction/?geo_lat=35.4437078&geo_lng=139.6380256&radius=10

Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...

Purchase: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, 2018

Report Name : Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, ... Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, 2018 ...

https://www.reportsnreports.com/purchase.aspx?name=1810263

Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster...

Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster ... Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster ...

https://ard.bmj.com/content/72/6/1003.responses

Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type | Annals...

Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type ... Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type ... Objective To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated ... vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO) antibodies) predicts treatment ...

http://ard.bmj.com/content/early/2015/11/30/annrheumdis-2015-208073.full

Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 -...

Your ticket for the: Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ... Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 - ...

https://www.vasculitisfoundation.org/feed-items/clinical-trials-on-global-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-anca-vasculitis-market-h2-2018-fashion-herald/

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and...

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and ... and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We sought to define pharmacodynamic biomarkers of ... Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and ... For AAV, 8 of 11 biomarkers of the anti-inflammatory response to glucocorticoids were validated (P-value

https://www.luriechildrens.org/en/research/publications/serum-biomarkers-of-glucocorticoid-response-and-safety-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-and-juvenile-dermatomyositis/

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis

Anti-neutrophils cytoplasmic antibodies (ANCA) are associated with a group of necrotizing small vessel vasculitides that ... Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis LabMed. Anti-Neutrophils Cytoplasmic Antibodies (ANCA) ... Exclusion tests may include complement C3 and C4, anti-GBM, ANA, anti-dsDNA, anti-Sm/RNP, and anti-SSA/SSB. ... because anti-nuclear antibodies (ANA) may produce similar staining patterns on neutrophil nuclei. A P-ANCA pattern should not ...

http://www.infectiousdiseaseadvisor.com/labmed/anti-neutrophils-cytoplasmic-antibodies-anca-associated-vasculitis/article/614958/

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis

Anti-neutrophils cytoplasmic antibodies (ANCA) are associated with a group of necrotizing small vessel vasculitides that ... Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis). *Survival in SLE-Related Pulmonary ... Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis LabMed. Anti-Neutrophils Cytoplasmic Antibodies (ANCA) ... Exclusion tests may include complement C3 and C4, anti-GBM, ANA, anti-dsDNA, anti-Sm/RNP, and anti-SSA/SSB. ...

https://www.thecardiologyadvisor.com/labmed/anti-neutrophils-cytoplasmic-antibodies-anca-associated-vasculitis/article/614959/

Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 -...

Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ... Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 - ...

https://www.vasculitisfoundation.org/feed-items/global-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-anca-vasculitis-clinical-trials-review-h2-2018-researchandmarkets-com-tullahoma-news-and-guardian/

Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a...

Background Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical ... Anti-neutrophil cytoplasmic autoantibody pathogenicity revisited: pathogenic versus non-pathogenic anti-neutrophil cytoplasmic ... ANCA anti-neutrophil cytoplasmic antibody, BVAS Birmingham Vasculitis Activity Score, EGPA eosinophilic granulomatosis with ... Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a ...

https://rd.springer.com/article/10.1186/s12891-015-0796-7

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Neurology Advisor

Close more info about Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) ... Close more info about Wegeners granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) ... a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status". J Cutan Pathol. vol. ... "Functional characterization of antineutrophil cytoplasmic antibodies in patients with cocaine-induced midline destructive ...

https://www.neurologyadvisor.com/decision-support-in-medicine/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/

Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated...

... induction of anti-neutrophil cytoplasmic antibody (ANCA), to the hosts. Since ANCA can induce NET formation in the primed ... which are extruded from activated neutrophils. Although NETs are essential in innate immunity, an excessive formation of NETs ... neutrophils, a positive feedback loop can be formed between NETs and ANCA, which is called ... Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), ...

https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-018-0953-y

Anti-neutrophil cytoplasmic antibody-associated vasculitis Pathway Map - PrimePCR | Life Science | Bio-Rad

Anti-neutrophil cytoplasmic antibody-associated vasculitis H96. Anti-neutrophil cytoplasmic antibody-associated vasculitis H384 ... Anti-neutrophil cytoplasmic antibody-associated vasculitis M96. Anti-neutrophil cytoplasmic antibody-associated vasculitis M384 ... Anti-neutrophil cytoplasmic antibody-associated vasculitis. print Email " style="padding-top:-15px;"> ... Anti-neutrophil cytoplasmic antibody-associated vasculitis H96 Predesigned 96-well panel for use with SYBR® Green ...

https://www.bio-rad.com/en-us/prime-pcr-assays/pathway/cardiovascular-diseases/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis

Severe Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic...

Pulmonary involvement in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: the influence of ANCA subtype ... Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic Antibodies (PR3 ... Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associate vasculitis ... and anti-MPO 0U/ml. Other studies, which included anti-glomerular basement membrane antibodies, ANA, complement, ...

http://archbronconeumol.org/en-severe-pulmonary-emphysema-in-young-articulo-S1579212918301496

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)

https://www.endocrinologyadvisor.com/dermatology/wegeners-granulomatosis-anti-neutrophil-cytoplasmic-antibody-anca-associated-vasculitis/article/592196/

A skin biopsy was performed to evaluate the purpuric lesions on his left leg and leukocytoclastic vasculitis was diagnosed. (biomedcentral.com)
This is the first reported case of leukocytoclastic vasculitis followed by purpura and acute renal failure associated with panitumumab. (biomedcentral.com)

Renal failure is also uncommon as an adverse event of anti-epidermal growth factor receptor antibody. (biomedcentral.com)

However, there are few reports of purpura induced by anti-epidermal growth factor receptor antibody. (biomedcentral.com)

Panitumumab is the first human combinatorial antibody for the treatment of metastatic colorectal carcinoma. (biomedcentral.com)
Panitumumab is a fully humanized antibody for the treatment of RAS wild-type metastatic colorectal carcinoma (mCRC). (biomedcentral.com)

The most common pattern is the cytoplasmic pattern utilizing indirect immunofluoresence (c-ANCA) and Proteinase-3 as the target antigen by solid phase ELISA test. (oncologynurseadvisor.com)
ANCA-associated vasculitis (AAV) commonly affects those of working age. (ovid.com)
GlobalData's clinical trial report, "Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017 provides an overview of Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) clinical trials scenario. (marketresearch.com)
This report provides top line data relating to the clinical trials on Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis). (marketresearch.com)
Previous reports suggested conventional immunosuppressants such as cyclophosphamide could not reduce glucocorticoid dose in remission induction in ANCA-associated vasculitis because of lower remission rate and higher relapse rate. (centerwatch.com)
B cell depletion therapy by rituximab is a new strategy for remission induction in ANCA-associated vasculitis. (centerwatch.com)
In addition, recent retrospective observational studies reported low-dose glucocorticoid plus rituximab led to re-induction in severe relapsing ANCA-associated vasculitis. (centerwatch.com)
Thus, the investigators aim to investigate whether rituximab can reduce glucocorticoid dose in induction remission in ANCA-associated vasculitis (to show non-inferiority for efficacy between low-dose and high-dose glucocorticoid plus rituximab). (centerwatch.com)
ANCA (anti-neutrophil cytoplasmic antibody)-associated vasculitis is characterised by small vessel vasculitis and presence of autoantibodies, ANCA. (centerwatch.com)
Current standard therapy in induction remission for ANCA-associated vasculitis is combination of high-dose glucocorticoid and IV-cyclophosphamide. (centerwatch.com)
Objective To evaluate whether the classification of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) according to ANCA type (anti-proteinase 3 (PR3) or anti-myeloperoxidase (MPO) antibodies) predicts treatment response. (bmj.com)
Methods Treatment responses were assessed among patients enrolled in the Rituximab in ANCA-associated Vasculitis trial according to both AAV diagnosis (granulomatosis with polyangiitis (GPA)/microscopic polyangiitis (MPA)) and ANCA type (PR3-AAV/MPO-AAV). (bmj.com)
Glucocorticoids are standard of care for many chronic inflammatory conditions, including juvenile dermatomyositis (JDM) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). (luriechildrens.org)
Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical service. (springer.com)
Systemic vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA) encompasses granulomatosis with polyangiitis (GPA, previously known as Wegener's granulomatosis), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA, previously known as Churg-Strauss syndrome). (springer.com)
ANCA-associated systemic vasculitis (AAV) has a prevalence of 14-30 patients per 100,000 [ 1 ] and its most frequent severe manifestations include rapidly progressive glomerulonephritis leading to dialysis-requiring renal failure and alveolar capillaritis leading to pulmonary haemorrhage. (springer.com)
Anti-neutrophils cytoplasmic antibodies (ANCA) are associated with a group of necrotizing small vessel vasculitides that usually have a paucity of vascular deposition of immunoglobulin and complement. (infectiousdiseaseadvisor.com)
This distinguishes ANCA associated disease from disease caused by anti-glomerular membrane antibodies and disease caused by immune complexes, both of which have deposition of pathogenic immune complexes in vessel walls. (infectiousdiseaseadvisor.com)
ANCA associated vasculitides include Wegener granulomatosis (WG), Microscopic polyangiitis (MPA) and its renal limited form, and Churg-Strauss syndrome (CSS). (infectiousdiseaseadvisor.com)
ANCA are the most important laboratory tests used to confirm the diagnosis of this group of vasculitides. (infectiousdiseaseadvisor.com)
ANCA are a heterogeneous group of autoantibodies, including antibodies with specificity for proteinase 3 (PR3) and myeloperoxidase (MPO). (infectiousdiseaseadvisor.com)
A C-ANCA pattern identified by indirect immunofluorescence staining of neutrophils (diffuse staining of the cytoplasm sparing the nuclei) usually correlates with PR3-ANCA. (infectiousdiseaseadvisor.com)
Although a P-ANCA (peri-nuclear staining) is usually associated with MPO-ANCA, antibodies specific for elastase, cathepsin G, and lactoferrin are also associated with P-ANCA. (infectiousdiseaseadvisor.com)
C-ANCA plus with anti-PR3 are sensitive markers for WG. (infectiousdiseaseadvisor.com)
P-ANCA with anti-MPO reactivity is less frequently found in WG and is associated with less organ involvement. (infectiousdiseaseadvisor.com)
In particular, P-ANCA may be difficult to interpret, because anti-nuclear antibodies (ANA) may produce similar staining patterns on neutrophil nuclei. (thecardiologyadvisor.com)
Although NETs are essential in innate immunity, an excessive formation of NETs has adverse effects, e.g., induction of anti-neutrophil cytoplasmic antibody (ANCA), to the hosts. (biomedcentral.com)
Since ANCA can induce NET formation in the primed neutrophils, a positive feedback loop can be formed between NETs and ANCA, which is called "ANCA-NETs vicious cycle. (biomedcentral.com)
Although the illness improved after cessation of hydralazine, MPO-ANCA-associated vasculitis relapsed 16 months later. (biomedcentral.com)
MPO-ANCA is the major pathogenic autoantibody in ANCA-associated vasculitis (AAV). (biomedcentral.com)
Pulmonary involvement is common in ANCA-associated vasculitis (AAV), but rarely manifests as pulmonary emphysema (13% of cases). (archbronconeumol.org)
We report the case of a 32-year-old man, smoker of 13 pack-years, with no exposure to other toxic substances, no family history, and no significant clinical history, who was diagnosed with anti-proteinase 3 (PR3) c-ANCA vasculitis and severe pulmonary emphysema. (archbronconeumol.org)
Diagnosis and management of ANCA associated vasculitis. (radiopaedia.org)
2. Kamesh L, Harper L, Savage CO. ANCA-positive vasculitis. (radiopaedia.org)
Management of ANCA-associated vasculitis: Current trends and future prospects. (radiopaedia.org)
Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA) are multisystem diseases of small blood vessels, collectively known as the anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). (ox.ac.uk)
Hydralazine-induced antinuclear cytoplasmic antibody (ANCA) vasculitis (AAV) is a rare phenomenon with pulmonary-renal syndrome with the most severe presentation. (bmj.com)
They are detected as a blood test in a number of autoimmune disorders, but are particularly associated with systemic vasculitis, so called ANCA-associated vasculitides. (wikipedia.org)
Immunofluorescence (IF) on ethanol-fixed neutrophils is used to detect ANCA, although formalin-fixed neutrophils may be used to help differentiate ANCA patterns. (wikipedia.org)
cytoplasmic ANCA (c-ANCA), C-ANCA (atypical), perinuclear ANCA (p-ANCA) and atypical ANCA (a-ANCA), also known as x-ANCA. (wikipedia.org)
c-ANCA shows cytoplasmic granular fluorescence with central interlobular accentuation. (wikipedia.org)
c-ANCA (atypical) shows cytoplasmic staining that is usually uniform and has no interlobular accentuation. (wikipedia.org)
p-ANCA has three subtypes, classical p-ANCA, p-ANCA without nuclear extension and granulocyte specific-antinuclear antibody (GS-ANA). (wikipedia.org)
a-ANCA often shows combinations of both cytoplasmic and perinuclear staining. (wikipedia.org)
Classical p-ANCA occurs with antibodies directed to MPO. (wikipedia.org)
p-ANCA without nuclear extension occurs with antibodies to BPI, cathepsin G, elastase, lactoferrin and lysozyme. (wikipedia.org)
Atypical ANCA are thought to be antigens similar to that of the p-ANCAs, however may occur due to differences in neutrophil processing. (wikipedia.org)
This theory solves the paradox of how it could be possible for antibodies to be raised against the intracellular antigenic targets of ANCA. (wikipedia.org)

Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the cytoplasm of neutrophil granulocytes (the most common type of white blood cell) and monocytes. (wikipedia.org)

5. Pesci A, Manganelli P. Respiratory system involvement in antineutrophil cytoplasmic-associated systemic vasculitides: clinical, pathological, radiological and therapeutic considerations. (radiopaedia.org)
Granulomatosis with polyangiitis is part of a larger group of vasculitic syndromes called systemic vasculitides or necrotizing vasculopathies, all of which feature an autoimmune attack by an abnormal type of circulating antibody termed ANCAs (antineutrophil cytoplasmic antibodies) against small and medium-size blood vessels. (wikipedia.org)

The interpretation of the antibody staining pattern using indirect immunofluorescence can be complicated by the presence of other antibodies. (thecardiologyadvisor.com)

Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis," Case Reports in Rheumatology , vol. 2018, Article ID 8192021, 4 pages, 2018. (hindawi.com)

Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), which are extruded from activated neutrophils. (biomedcentral.com)

In vitro studies have found that ANCAs can activate neutrophils, increase their adherence to endothelium, and induce their degranulation that can damage endothelial cells. (wikipedia.org)

ANCAs are associated with small vessel vasculitides including granulomatosis with polyangiitis (previously known as Wegener's granulomatosis), microscopic polyangiitis, primary pauci-immune necrotizing crescentic glomerulonephritis (a type of renal-limited microscopic polyangiitis), eosinophilic granulomatosis with polyangiitis (previously known as Churg-Strauss syndrome) and drug induced vasculitides. (wikipedia.org)

Evidence-based recommendations on rituximab (MabThera) with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis in adults. (nice.org.uk)
Current standard of care for the initial treatment of AAV is glucocorticoids in combination with either cyclophosphamide (CYC) or the B cell depleting antibody, rituximab. (springer.com)

Patients can present with a dry cough, hemoptysis, bilateral diffuse lung infiltrate revealed by a chest X ray, sinusitis, otitis, cutaneous vasculitis, or a rapidly progressive glomerulonephritis. (infectiousdiseaseadvisor.com)
Other extra-renal symptoms may include cutaneous vasculitis or mononeuritis multiplex. (infectiousdiseaseadvisor.com)
Systemic features can include cutaneous vasculitis lesions, neuropathy, paranasal sinus abnormality, or pulmonary infiltrates. (infectiousdiseaseadvisor.com)
Arthritis: Pain or swelling (60%), often initially diagnosed as rheumatoid arthritis Skin: nodules on the elbow, purpura, various others (see cutaneous vasculitis) Nervous system: occasionally sensory neuropathy (10%) and rarely mononeuritis multiplex Heart, gastrointestinal tract, brain, other organs: rarely affected. (wikipedia.org)
If the person has kidney failure or cutaneous vasculitis, a biopsy is obtained from the kidneys. (wikipedia.org)

GS-ANA are antibodies directed to granulocyte specific nuclear antigens. (wikipedia.org)
Although IF can be used to screen for many ANCAs, ELISA is used to detect antibodies to individual antigens. (wikipedia.org)

The typical ANCAs in GPA are those that react with proteinase 3, an enzyme prevalent in neutrophil granulocytes. (wikipedia.org)
Cytoplasmic-staining ANCAs that react with the enzyme proteinase 3 (cANCA) in neutrophils (a type of white blood cell) are associated with GPA. (wikipedia.org)

Patient perceptions of glucocorticoids in anti-neutrophil cytoplasmic antibody-associated vasculitis. (ox.ac.uk)

Anti-neutrophil cytoplasmic antibody-associated vasculitides refer to a group of heterogeneous autoimmune diseases characterized by necrotizing vasculitides and positive anti-neutrophil antibody titers. (radiopaedia.org)

Neutrophil apoptosis, or programmed cell death, is vital in controlling the duration of the early inflammatory response, thus restricting damage to tissues by the neutrophils. (wikipedia.org)

WG must be differentiated from other systemic vasculitis syndromes including Churg-Strauss granulomatosis, polyarteritis nodosum, and others. (oncologynurseadvisor.com)

It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs. (wikipedia.org)

These vasculitides affect arterioles, capillaries, and venules which can involve virtually any organ with varying degrees of severity. (radiopaedia.org)

Skin biopsies show leukocytoclastic vasculitis when purpuric lesions are biopsied ( Figure 3 ). (oncologynurseadvisor.com)

Extra-renal organ manifestations and respiratory track granulomas occur more frequently in patients with anti-PR3 than those with anti-MPO. (infectiousdiseaseadvisor.com)

NET induction activity was high in Sera A, B, and C but not in D. Additionally, we demonstrated the presence of anti-NET antibody (ANETA) in Sera B and C but not in A or D. (biomedcentral.com)

2) hydralazine-induced reversal of epigenic silencing of MPO and proteinase3 (PR3) leading to increased expression of neutrophil autoantigens and (3) a break in tolerance in slow versus fast acetylators of hydralazine. (bmj.com)

Other more recent reports of widespread livedo and acral purpura due to vascular coagulation similar to that seen in livedoid vasculitis but with a much more rapid, widespread and intense onset have been linked to cocaine laced with levamasole. (oncologynurseadvisor.com)

The identified efficacy biomarkers may be useful as objective outcome measures for early phase proof-of-concept studies when assessing novel anti-inflammatory drugs in JDM and AAV, and likely in other inflammatory disorders. (luriechildrens.org)

Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts. (1/99)

Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcgamma receptors. (2/99)

CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis. (3/99)

Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody-associated vasculitides: a matched-pair cohort study. (4/99)

Small vessel vasculitis. (5/99)

Spontaneous resolution of delayed onset large subclavian artery pseudoaneurysm. (6/99)

Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis. (7/99)

Prediction of ESRD in pauci-immune necrotizing glomerulonephritis: quantitative histomorphometric assessment and serum creatinine. (8/99)

Eosinophilic granulomatosis with polyangiitis

Anti-neutrophil cytoplasmic antibody

Granulomatosis with polyangiitis

P-ANCA

Necrotizing vasculitis

Myeloperoxidase

Microscopic polyangiitis

Rapidly progressive glomerulonephritis

Ronald J. Falk

Hypereosinophilia

Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody...

Nasal Septal Perforation in Propylthiouracil-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - ONA

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)

Evidence | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...

Overview | Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated...

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Renal and Urology News

Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H1, 2017

Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...

Low-dose Glucocorticoid Vasculitis Induction Study | Clinical Research Trial Listing ( Anti-Neutrophil Cytoplasmic Antibody...

Purchase: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Global Clinical Trials Review, H2, 2018

Revisiting the classification of clinical phenotypes of anti-neutrophil cytoplasmic antibody-associated vasculitis: a cluster...

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Clinical Trials On Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Market, H2, 2018 -...

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and...

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis

Anti-Neutrophils Cytoplasmic Antibodies (ANCA) Associated Vasculitis

Global Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (ANCA Vasculitis) Clinical Trials Review, H2, 2018 -...

Benefits of an expanded use of plasma exchange for anti-neutrophil cytoplasmic antibody-associated vasculitis within a...

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis) - Neurology Advisor

Anti-neutrophil extracellular trap antibody in a patient with relapse of anti-neutrophil cytoplasmic antibody-associated...

Anti-neutrophil cytoplasmic antibody-associated vasculitis Pathway Map - PrimePCR | Life Science | Bio-Rad

Severe Pulmonary Emphysema in a Young Patient With Vasculitis Associated with Proteinase-3 Anti-Neutrophil Cytoplasmic...

Wegener's granulomatosis (anti-neutrophil cytoplasmic antibody, ANCA-associated vasculitis)

Leukocytoclastic vasculitis2

Renal1

Purpura1

Treatment2

ANCA48

Autoantibodies1

Systemic vasculitides2

Immunofluorescence1

Rheumatology1

Myeloperoxidase1

Activate neutrophils1

Granulomatosis with polyangiitis1

Rituximab2

Cutaneous vasculitis5

Antigens2

Proteinase2

Glucocorticoids1

Autoimmune diseases1

Apoptosis1

Syndromes1

Blood vessels1

Arterioles1

Lesions1

Respiratory1

Induction1

Hydralazine1

Vascular1

Studies1