Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Inflammation
Okadaic Acid
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Transcription Factor RelA
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Inflammation Mediators
I-kappa B Kinase
I-kappa B Proteins
NF-kappa B
Interleukin-1
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Tetradecanoylphorbol Acetate
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Cells, Cultured
Spirostans
Gene Expression Regulation
Saponins
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Diosgenin
Tomatine
Liliaceae
A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.
Solanaceous Alkaloids
Chlormadinone Acetate
Molecular Structure
Pregnanes
Cynanchum
Estrogen Antagonists
Rhizome
Magnetic Resonance Spectroscopy
Dracaena
Smilax
Buxaceae
Solanum
Dioscorea
Allium
Aromatase Inhibitors
Withanolides
Plant Extracts
Testolactone
Holarrhena
Estradiol
Anemarrhena
Hydroxysteroids
Stereoisomerism
Asparagus Plant
Spectrometry, Mass, Fast Atom Bombardment
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Solanum nigrum
Alveolectomy
Androstenes
Withania
Agave
Ophiopogon
Chloroquinolinols
8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.
Trillium
Gestrinone
Hemolytic Agents
Androstanols
Marsdenia
Solanaceae
Agavaceae
A plant family of the order Liliales, subclass Liliidae, class Liliopsida. Members of the family have narrow, lance-shaped, sometimes fleshy or toothed leaves that are clustered at the base of each plant. Most species have large flower clusters containing many flowers. The fruit is a capsule or berry.
Fritillaria
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Veratrum
Cyproterone Acetate
Subgingival Curettage
Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)
Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension. (1/7426)
OBJECTIVE: To investigate the usefulness of hydroxychloroquine (HCQ) dose-loading to increase the percentage of responders or rate of response in treating rheumatoid arthritis (RA). METHODS: Two hundred twelve patients with early RA (mean duration 1.5 years) were enrolled in a 24-week trial. Patients were stabilized with 1,000 mg naproxen/day and then began a 6-week, double-blind trial comparing treatment with HCQ at 400 mg/day (n = 71), 800 mg/day (n = 71), and 1,200 mg/day (n = 66), followed by 18 weeks of open-label HCQ treatment at 400 mg/day. RESULTS: All patients had mild, active disease at the time of initiation of HCQ treatment (31-43% rheumatoid factor positive; no previous disease-modifying antirheumatic drugs; mean swollen joint count 8.6-10.4). Based on the Paulus criteria, response during the 6-week double-blind portion of the study was 47.97%, 57.7%, and 63.6% in the 400 mg/day, 800 mg/day, and 1,200 mg/day groups, respectively (P = 0.052). Discontinuations for adverse events were dose related (3 in the 400 mg/day group, 5 in the 800 mg/day group, 6 in the 1,200 mg/day group). Most involved the gastrointestinal (GI) system, with the background naproxen treatment possibly contributing. Ocular abnormalities occurred in 17 of 212 patients (8%) but were not dose related. CONCLUSION: Dose-loading with HCQ increased the degree of response at 6 weeks in this group of patients with early, predominantly seronegative RA. Adverse GI events were dose related, while adverse ocular events were not. (+info)Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. (2/7426)
Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorigenesis. We have examined apoptosis induction by non-steroidal anti-inflammatory drugs (NSAIDs) in human gastric (AGS) cancer cells and the role of protein kinase C (PKC) and apoptosis-related oncogenes. After treatment with aspirin or indomethacin, cell growth was quantified by MTT assay, and apoptosis was determined by acridine orange staining, DNA fragmentation and flow cytometry. The mRNA and protein of p53, p21waf1/cip1 and c-myc was detected by Northern and Western blotting respectively. The influence of PKC on indomethacin-induced apoptosis was determined by co-incubation of 12-O-tetradecanoylphorbol 13-acetate (TPA). The role of c-myc was determined using its antisense oligonucleotides. The results showed that both aspirin and indomethacin inhibited cell growth and induced apoptosis of AGS cells in a dose- and time-dependent manner, without altering the cell cycle. Indomethacin increased c-myc mRNA and protein, whereas p53 and p21wafl/cip1 were unchanged. Down-regulation of c-myc by its antisense oligonucleotides reduced apoptosis induction by indomethacin. TPA could inhibit indomethacin-induced apoptosis and accumulate cells in G2/M. Overexpression of c-myc was inhibited by TPA and p21waf1/cip1 mRNA increased. In conclusion, NSAIDs induce apoptosis in gastric cancer cells which may be mediated by up-regulation of c-myc proto-oncogene. PKC activation can abrogate the effects of NSAIDs by decreasing c-myc expression. (+info)A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (3/7426)
The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted. (+info)Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. (4/7426)
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7.3 x 10(-6) mole fraction, which approached the stiochiometric limit of this assay. The true potency of LY315920 was defined using a deoxycholate/phosphatidylcholine assay with a mole fraction of 1.5 x 10(-6). LY315920 was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase. Human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells was inhibited by LY315920 with an IC50 of 0.79 microM. The release of TXA2 from these cells by N-formyl-methionyl-leucyl-phenylalanine or arachidonic acid was not inhibited. The i.v. administration of LY315920, 5 min before harvesting the bronchoalveolar lavage cells, resulted in the inhibition of sPLA2-induced production of TXA2 with an ED50 of 16.1 mg/kg. Challenge of guinea pig lung pleural strips with sPLA2 produced contractile responses that were suppressed in a concentration-dependent manner by LY315920 with an apparent KB of 83 +/- 14 nM. Contractile responses induced by arachidonic acid were not altered. Intravenous or oral administration of LY315920 to transgenic mice expressing the human sPLA2 protein inhibited serum sPLA2 activity in a dose-related manner over a 4-h time course. LY315920 is a potent and selective sPLA2 inhibitor and represents a new class of anti-inflammatory agent designated SPI. This agent is currently undergoing clinical evaluation and should help to define the role of sPLA2 in various inflammatory disease states. (+info)Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. (5/7426)
The marked analgesic efficacy of ketorolac in humans, relative to other nonsteroidal anti-inflammatory drugs (NSAIDs), has lead to speculation as to whether additional non-NSAID mechanism(s) contribute to its analgesic actions. To evaluate this possibility, we characterized (R,S)-ketorolac's pharmacological properties in vivo and in vitro using the nonselective cyclooxygenase (COX) inhibitors [indomethacin (INDO) and diclofenac sodium (DS)] as well as the selective COX-2 inhibitor, celecoxib, as references. The potency of racemic (R,S)-ketorolac was similar in tests of acetic acid-induced writhing, carrageenan-induced paw hyperalgesia, and carrageenan-induced edema formation in rats; ID50 values = 0.24, 0. 29, and 0.08 mg/kg, respectively. (R,S)-ketorolac's actions were stereospecific, with (S)-ketorolac possessing the biological activity of the racemate in the above tests. The analgesic potencies for (R,S)-, (S)-, and (R)-ketorolac, INDO, and DS were highly correlated with their anti-inflammatory potencies, suggesting a common mechanism. (R,S)-ketorolac was significantly more potent than INDO or DS in vivo. Neither difference in relative potency of COX inhibition for (R,S)-ketorolac over INDO and DS nor activity of (S)-ketorolac at a number of other enzymes, channels, or receptors could account for the differences in observed potency. The distribution coefficient for (R,S)-ketorolac was approximately 30-fold less than for DS or INDO, indicating that (R,S)-ketorolac is much less lipophilic than these NSAIDs. Therefore, the physicochemical and pharmacokinetics properties of (R,S)-ketorolac may optimize the concentrations of (S)-ketorolac at its biological target(s), resulting in greater efficacy and potency in vivo. (+info)Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (6/7426)
1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent scratching of the injected site with the forepaws and hindpaws. 2. Up to 100 microg of sodium deoxycholic acid induced no significant increase in vascular permeability at the injection site as assessed by a dye leakage method. 3. Bradykinin (BK) B2 receptor antagonists, FR173657 and Hoe140, significantly decreased the frequency of scratching induced by sodium deoxycholic acid. 4. Treatment with aprotinin to inhibit tissue kallikrein reduced the scratching behaviour induced by sodium deoxycholic acid, whereas treatment with soybean trypsin inhibitor to inhibit plasma kallikrein did not. 5. Although injection of kininase II inhibitor, lisinopril together with sodium deoxycholic acid did not alter the scratching behaviour, phosphoramidon, a neutral endopeptidase inhibitor, significantly increased the frequency of scratching. 6. Homogenates of the skin excised from the backs of mice were subjected to gel-filtration column chromatography followed by an assay of kinin release by trypsin from each fraction separated. Less kinin release from the fractions containing kininogen of low molecular weight was observed in the skin injected with sodium deoxycholic acid than in normal skin. 7. The frequency of scratching after the injection of sodium deoxycholic acid in plasma kininogen-deficient Brown Norway Katholiek rats was significantly lower than that in normal rats of the same strain, Brown Norway Kitasato rats. 8. These results indicate that BK released from low-molecular-weight kininogen by tissue kallikrein, but not from high-molecular-weight kininogen by plasma kallikrein, may be involved in the scratching behaviour induced by the injection of sodium deoxycholic acid in the rodent. (+info)The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. (7/7426)
To determine whether declining semen quality associated with health problems may be due to certain antibiotic or anti-inflammatory treatments, semen was collected 3 times per week for up to 42 d from 6 normal bulls after treatment with oxytetracycline, tilmicosin, dihydrostreptomycin, or phenylbutazone. No adverse effects on semen quality were observed. (+info)Pseudogout attack associated with chronic thyroiditis and Sjogren's syndrome. (8/7426)
A 66-year-old woman, diagnosed with chronic thyroiditis at age 63, presented with anorexia and fatigue. Therapy for the chronic thyroiditis consisted of levothyroxine sodium (100 microg/day). Her symptoms were attributed to the insufficient supply of levothyroxine sodium. Following a dosage increase to 150 microg/day, she suffered from an acute attack of pseudogout. Clinical features were complicated by Sjogren's syndrome, which appeared after treatment onset. Pseudogout was effectively treated by colchicine after administration of diclofenac sodium failed to alleviate the symptoms. Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjogren's syndrome has not been previously reported. (+info)
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Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats.<...
Abstract: Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2...
Protection of Ischemia-Reperfusion Induced Cell Death by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Rat Retina |...
Coxibs and Other Nonsteroidal Anti-Inflammatory Drugs in Animal Models of Cancer Chemoprevention | Cancer Prevention Research
Limited inhibitory effects of non-steroidal antiinflammatory drugs on in vitro osteogenic differentiation in canine cells.
Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers - Tabular View -...
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Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study | BMC Public Health | Full Text
Advanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review | Bentham Science
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Role of a nonsteroidal anti-inflammatory agent, ibuprofen, in coronary revascularization after acute myocardial infarction |...
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Cyclooxygenase 2 Polymorphism (Val511Ala), Nonsteroidal Anti-inflammatory Drug Use and Breast Cancer in African American Women ...
Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast...
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Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug...
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Iraqi Academic Scientific Journals - IASJ
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Intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs: Role of bile salts<...
Risks of gastrointestinal ulcers linked to aspirin use might outweigh its benefits for the heart
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Among them are serotonin, a neurotransmitter; indometacin, a non-steroidal anti-inflammatory agent; L-761,066, a COX-2 ...
Degenerative disc disease
... oral analgesia with non-steroidal anti-inflammatory agents (NSAIDS); and topical analgesia with lidocaine, ice and heat. ... anti-inflammatory medications such as nonsteroidal anti-inflammatory drugs, traction, or epidural steroid injection often ...
Benoxaprofen
Somerville KW, Hawkey CJ (January 1986). "Non-steroidal anti-inflammatory agents and the gastrointestinal tract". Postgraduate ... Doube A (July 1990). "Hepatitis and non-steroidal anti-inflammatory drugs". Annals of the Rheumatic Diseases. 49 (7): 489-90. ... Dahl SL, Ward JR (1982). "Pharmacology, clinical efficacy, and adverse effects of the nonsteroidal anti-inflammatory agent ... Benoxaprofen had a considerably anti-inflammatory, analgesic and also anti-pyretic activity in those tests. In all six animals ...
Diabetic retinopathy
Cochrane Eyes and Vision Group) (February 2015). "Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular ... steroidal anti‐inflammatory agents. Instead of laser surgery, some people require a vitrectomy to restore vision. A vitrectomy ... These three treatments are laser surgery, injection of corticosteroids or anti-VEGF agents into the eye, and vitrectomy. ... It is often more prudent to inject triamcinolone or anti-VEGF drugs. In some patients it results in a marked increase of vision ...
Amfenac
... a non-steroidal anti-inflammatory agent". Journal of Pharmacobio-dynamics. 11 (9): 612-9. doi:10.1248/bpb1978.11.612. PMID ... Amfenac, also known as 2-amino-3-benzoylbenzeneacetic acid, is a nonsteroidal anti-inflammatory drug (NSAID) with acetic acid ...
Cochrane Eyes and Vision
Sivaprasad, Sobha; Bunce, Catey; Crosby-Nwaobi, Roxanne (2012-02-15). "Non-steroidal anti-inflammatory agents for treating ... and antiviral agents for herpes simplex virus. "Cataract in the Adult Eye PPP - 2016". American Academy of Ophthalmology. 2016- ...
Oxaprozin
... two novel series of non-steroidal anti-inflammatory agents. This article was published in Nature in 1968. In December 1988, ... Two Novel Series of Non-steroidal Anti-inflammatory Agents". Nature. 219 (5150): 164. Bibcode:1968Natur.219..164B. doi:10.1038/ ... Wang, Runsheng (6 Aug 2015). "Comparative efficacy of non-steroidal anti-inflammatory drugs in ankylosing spondylitis: a ... Following the filing of the patent, the first description of oxaprozin exhibiting anti-inflammatory properties was outlined in ...
Estradiol sulfate
"Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents". Current Drug ...
Ruscus aculeatus
Ruscogenins function as anti-inflammatory agents and are also believed to cause constriction in veins. Currently the mode of ... The major phytochemicals in butcher's broom are steroidal saponins. Saponins occur naturally in plants as glycosides and have ... "Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear ... Sahu, N. P.; Banerjee, S.; Mondal, N. B.; Mandal, D. (2008), "Steroidal Saponins", Fortschritte der Chemie organischer ...
Ditazole
... is a non-steroidal anti-inflammatory agent with analgesic and antipyretic activity similar to phenylbutazone. It is ...
Meloxicam
"Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with ... Höglund OV, Dyall B, Gräsman V, Edner A, Olsson U, Höglund K (October 2018). "Effect of non-steroidal anti-inflammatory drugs ... Metacam is a prescription non-steroidal anti-inflammatory drug (NSAID) that is used to control pain and inflammation (soreness ... Meloxicam, sold under the brand name Mobic among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain ...
Pel-Ebstein fever
Treatment with non-steroidal anti-inflammatory agents or treatment of the underlying Hodgkin's (usually with chemotherapy) will ...
Mycoremediation
... anti-epileptic and non-steroidal anti-inflammatory drugs; X-ray contrast agents; polycyclic musk fragrances; and ingredients of ... X-ray contrast agents, and ingredients of personal care products, can be broken down in a non-toxic way. Mycoremediation is a ...
Wikipedia:WikiProject Medicine/Cochrane/Cochrane Review List/Musculoskeletal, Oral, Skin and Sensory
Done Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular oedema PMID 25686158 https://doi.org/10.1002/ ... Done Anti-tumour necrosis factor biological therapies for the treatment of uveitic macular oedema (UMO) for non-infectious ... Done Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema PMID 29669176 ... Done Anti-vascular endothelial growth factor for choroidal neovascularisation in people with pathological myopia PMID 27977064 ...
Ketorolac
Sivaprasad S, Bunce C, Crosby-Nwaobi R (February 2012). "Non-steroidal anti-inflammatory agents for treating cystoid macular ... "Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions". The Cochrane Database of ... "Prophylactic non-steroidal anti-inflammatory drugs for the prevention of macular oedema after cataract surgery". The Cochrane ... "Non-Steroidal Anti-Inflammatory Drugs and Aspirin Therapy for the Treatment of Acute and Recurrent Idiopathic Pericarditis". ...
Pleurisy
Non-steroidal anti-inflammatory drugs (NSAIDs), preferably indometacin, are usually employed as pain control agents. A number ... The extract is thought to inhibit the same enzyme, cyclooxygenase-2 (COX-2), as the non-steroidal anti-inflammatory drugs. ... A couple of medications are used to relieve pleurisy symptoms: Paracetamol (acetaminophen) or anti-inflammatory agents to ... 1999). "Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice". Life Sci ...
Oleocanthal
Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils". Organic ... Similar to classical non-steroidal anti-inflammatory drugs, it is a non-selective inhibitor of cyclooxygenase (COX). 50 g (more ... a natural anti-inflammatory agent in extra virgin olive oils". Chem Senses. 34 (4): 333-9. doi:10.1093/chemse/bjp006. PMC ... "Against this background, the in vivo anti-inflammatory effects of dietary oleocanthal cannot be as relevant as hypothesized by ...
Chamomile
... is not recommended to be taken with aspirin or non-salicylate NSAIDs (non-steroidal anti-inflammatory drugs), as it ... Apigenin, a phytochemical in chamomile, may interact with anticoagulant agents and nonsteroidal anti-inflammatory drugs, while ... Chamomile is under preliminary research for its potential anti-anxiety properties. There is no high-quality clinical evidence ... scentless or false chamomile Chamomile may be used as a flavoring agent in foods and beverages, mouthwash, soaps, or cosmetics ...
Diphenylphosphoryl azide
A new synthesis of some non-steroidal anti-inflammatory agents with the 2-arylpropionic acid skeleton by the use of diphenyl ...
HU-308
... antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs) Karsak M, ... inflammatory response, and apoptosis (programmed cell death). HU-308 is also classified as a non-steroidal anti-inflammatory ... HU-308 has shown interesting properties such as anti-inflammatory, analgesic, neuroprotective, antitumor and anti-osteoporitic ... The antinociceptive and anti-inflammatory effects of HU-308, but not Δ8THC or CBD, were mediated through CB2R, and reduces ...
Cystic kidney disease
Options include pain medication (except ibuprofen and other 'non-steroidal anti-inflammatory agents (NSAID's)' which may worsen ...
12-Hydroxyheptadecatrienoic acid
... other non-steroidal anti-inflammatory agents (NSAID) in humans. Synthetic BLT2 agonists may be useful for speeding the healing ... Opposition between the pro-inflammatory LTB4/BLT1 and anti-inflammatory actions of the 12-HHT/BLT2 axes occurs in another ... exerting an anti-inflammatory activity". Experimental & Molecular Medicine. 44 (6): 378-86. doi:10.3858/emm.2012.44.6.043. PMC ... and other agents. BLT2 may ultimately prove to have binding specificity for a similarly broad range of agents. The production ...
20-Hydroxyeicosatetraenoic acid
... enzymes which metabolize 20-HETE such as non-steroidal anti-inflammatory agents, opioids, gemfibrozil, Lasix, propanol, and ... Many agents stimulate cells and tissues to produce 20-HETE in vitro and in vivo. Androgens are particularly potent stimulators ... There are a variety of pharmacological agents which inhibit the synthesis of 20-HETE including various fatty acid analogs that ... This metabolism-induced inactivation may underlie the proposed roles of the cytochromes in dampening inflammatory responses and ...
Aceglutamide
... on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese Journal of Pharmacology. ... Tanaka, H; Shuto, K; Marumo, H (1982). "Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, ... 35-. ISBN 978-0-8155-1856-3. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ... and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor ...
Prevention of dementia
Hirohata M, Ono K, Naiki H, Yamada M (December 2005). "Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects ... It increases cerebral blood flow and is an anti-inflammatory agent, enhancing activity at the neuronal synapses in the brain. ... Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer's and Parkinson's diseases. The ... Etminan M, Gill S, Samii A (July 2003). "Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: ...
Anti-inflammatory
More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... "Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis". British Medical Journal (Clinical ... Nonsteroidal anti-inflammatory drugs[edit]. Main article: Nonsteroidal anti-inflammatory drug. Nonsteroidal anti-inflammatory ... Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs ...
Nonsteroidal anti-inflammatory drug
"Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury". Cochrane Database ... Jaturapatporn D, Isaac MG, McCleery J, Tabet N (February 2012). "Aspirin, steroidal and non-steroidal anti-inflammatory drugs ... "Non-steroidal anti-inflammatory drugs". British National Formulary. Retrieved 28 August 2019. Danelich IM, Wright SS, Lose JM, ... Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which ...
Idiopathic orbital inflammatory disease
... non-steroidal anti-inflammatory drugs, cytotoxic agents (chlorambucil, cyclophosphamide), corticosteroid sparing ... 121(4):491-9, 2003 Narla LD et al: Inflammatory Pseudotumor. RadioGraphics. 23(3):719-729, 2003 Belanger C et al: Inflammatory ... Idiopathic orbital inflammatory (IOI) disease, refers to a marginated mass-like enhancing soft tissue involving any area of the ... Idiopathic orbital inflammatory syndrome, also known as orbital pseudotumor, was first described by Gleason in 1903 and by ...
Nephrology
... nephrotoxins like radiologic contrast and non-steroidal anti-inflammatory drugs), antihypertensives, diet and weight ... Commonly used agents are prednisone, mycophenolate, cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and ... An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D ... Auto-immune and inflammatory kidney disease, such as vasculitis or transplant rejection, may be treated with immunosuppression ...
GABAA receptor positive allosteric modulator
This was shown when the anti-hyperalgesic action was reduced when administered in α2 and α3 mice in inflammatory pain and in ... In a rat brain slice preparation, the synthetic steroidal anesthetic alphaxalone (5α-pregnan-3α-ol-11,20 dione) enhanced both ... Sedative actions of benzodiazepines limit their usefulness as analgesic agents and they are therefore generally not considered ... Additionally, studies in α5 mice showed that the spinal α5-containing GABAA receptor has a minor role in inflammatory pain. An ...
Acute inhalation injury
These include β2-agonists, dopamine, insulin, allopurinol, and non-steroidal anti-inflammatory drugs (NSAIDs), such as ... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ... These agents are less likely to produce early warning signs (phosgene in low concentrations has a pleasant odor), are more ...
Drug class
Strictly speaking, and also historically, the wider class of anti-inflammatory drugs also comprises steroidal anti-inflammatory ... not all triglyceride lowering agents are PPAR agonists, and not all drugs that are used to treat atherosclerosis are ... "nonsteroidal anti-inflammatory drugs" (NSAIDs) is thus composed by one element ("anti-inflammatory") that designates the ... The class of nonsteroidal anti-inflammatory drugs (NSAIDs) is one such example. ...
Arachidonate 5-lipoxygenase
Aspirin and other non-steroidal anti-inflammatory drugs (NSAID) can cause NSAID-exacerbated diseases (N-ERD). These have been ... Alox5 and presumably human ALOX5 functions may vary widely depending on the agents stimulating their and types of metabolites ... leukotriene production involved in inflammatory response. • leukotriene biosynthetic process. • inflammatory response. • ... Alox5 enzyme some of which possess opposing activities like the pro-inflammatory chemotactic factors and the anti-inflammatory ...
Colostrum
... reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability". Clinical Science (London, ... turning it up when the body comes under attack from pathogens or other disease agents, and damping it when the danger is ... drugs and infectious microbes not only damages the gut but can lead to influx of damaging agents into the bloodstream. These ... through its immunoglobulin and other anti-microbial factors) and growth/healing factor constituents.[55] As pointed out by ...
Autoimmunity
The details of parasite immune modulation are not yet known, but may include secretion of anti-inflammatory agents or ... Steroidal or NSAID treatment limits inflammatory symptoms of many diseases. IVIG is used for CIDP and GBS. Specific ... Treatments for autoimmune disease have traditionally been immunosuppressive, anti-inflammatory, or palliative.[8] Managing ... 2002) injected an anti-MHC Class II antibody into mice expressing a single type of MHC Class II molecule (H-2b) to temporarily ...
Saline (medicine)
... non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics or topical anesthetics. Eye drops sometimes do not have medications ... Hypertonic saline-7% NaCl solutions are considered mucoactive agents and thus are used to hydrate thick secretions (mucus) in ...
Aspirin
... is used as an anti-inflammatory agent for both acute and long-term inflammation,[37] as well as for treatment of ... Verdoodt F, Friis S, Dehlendorff C, Albieri V, Kjaer SK (February 2016). "Non-steroidal anti-inflammatory drug use and risk of ... 1982). "Aspirin and similar analgesic and anti-inflammatory agents". Martindale: the extra pharmacopoeia (28th ed.). ... "FDA strengthens warning of heart attack and stroke risk for non-steroidal anti-inflammatory drugs". FDA. Archived from the ...
Hangover
Non-steroidal anti-inflammatory drugs such as aspirin or ibuprofen have been proposed as a treatment for the headaches ... Agents and Actions. 4 (2): 125-30. doi:10.1007/BF01966822. PMID 4842541.. ... "Anti-Hangover Tips". The Webtender. Retrieved 2010-03-26.. *^ McGregor NR (November 2007). "Pueraria lobata (Kudzu root) ...
Diabetic nephropathy
Some of the most commonly used nephrotoxic medications are non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.[43 ... Glycemic control is maintained mainly with insulin in patients with Type 1 DM and with hypoglycemic agents and/or insulin in ... it is recommended that only one agent is used in patients with DM who have hypertension or any signs of microalbuminuria or ... Although RAAS blockade using more than one agent may further reduce proteinuria, the risk of adverse events (such as ...
阿司匹林 - 維基百科,自由的百科全書
FDA Strengthens Warning of Heart Attack and Stroke Risk for Non-Steroidal Anti-Inflammatory Drugs. FDA. 2015-07-09 [2015-07-09] ... EF Reynolds (編). Aspirin and similar analgesic and anti-inflammatory agents. Martindale: The Extra Pharmacopoeia 28th: 234-82. ... Pharmacokinetic Solubility And Dissolution Profile of Non-Steroidal Anti-Inflammatory Drugs 2 (3). 2011.. ... Nonsteroidal anti-inflammatory drug-induced reactions and desensitization. J Asthma. 2004, 41 (4): 375-84. PMID 15281324. doi: ...
Colorectal cancer
Aspirin and other non-steroidal anti-inflammatory drugs decrease the risk.[2][11] Their general use is not recommended for this ... adding chemotherapy agents fluorouracil, capecitabine or oxaliplatin increases life expectancy. If the lymph nodes do not ... "Aspirin or Nonsteroidal Anti-inflammatory Drugs for the Primary Prevention of Colorectal Cancer". United States Department of ... Inflammatory bowel diseaseEdit. People with inflammatory bowel disease (ulcerative colitis and Crohn's disease) are at ...
COVID-19, a enciclopedia libre
"FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19". Drug Safety and Availability (en ... "International Journal of Antimicrobial Agents 55 (6): 105948. PMC 7156162. PMID 32201353. doi:10.1016/j.ijantimicag.2020.105948 ... Anti-tormenta de citocinas[editar , editar a fonte]. A tormenta de citocinas é unha condición médica que pode ser mortal e pode ... "Coronavirus, via libera dell'Aifa al farmaco anti-artrite efficace su 3 pazienti e a un antivirale: test in 5 centri" [ ...
WHO Model List of Essential Medicines
Non-opioids and non-steroidal anti-inflammatory medicines (NSAIMs)[edit]. A skeletal model of the chemical structure of aspirin ... Lipid-lowering agents[edit]. *Simvastatin[note 72]. Dermatological medicines (topical)[edit]. Antifungal medicines[edit]. * ... Not recommended for anti‐inflammatory use due to lack of proven benefit to that effect ... Anti-infective medicines[edit]. Anthelminthics[edit]. Intestinal anthelminthics[edit]. A skeletal model of the chemical ...
Prednisone
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... Steroidal: 6β-Hydroxy-7α-thiomethylspironolactone. *7α-Acetylthio-17α-hydroxyprogesterone ... Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties.[32][33] Prednisone is ... "Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...
Indometacin
Main article: Non-steroidal anti-inflammatory drug. Indometacin, a non-steroidal anti-inflammatory drug (NSAID), has similar ... A New Non-steroid Anti-inflammatory Agent". British Medical Journal. 2 (5363): 965-70. doi:10.1136/bmj.2.5363.965. PMC 1873102 ... Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription ... As an NSAID, indometacin is an analgesic, anti-inflammatory, and antipyretic. Clinical indications for indometacin include:. ...
Prostaglandin
Lethaby A, Duckitt K, Farquhar C (January 2013). "Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding". The ... but also neutralized the changes of the retina and the choroid thickness caused by the injection of pro-inflammatory agents. ... Tikhonovich MV, Erdiakov AK, Gavrilova SA (August 2018). "Nonsteroid anti-inflammatory therapy suppresses the development of ... Release of prostaglandins and other inflammatory mediators in the uterus cause the uterus to contract. These substances are ...
COX-2 inhibitor
"Non-steroidal anti-inflammatory drugs for acute gout". The Cochrane Database of Systematic Reviews. 9: CD010120. doi:10.1002/ ... "Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents". Journal of the ... "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of ... The existing nonsteroidal anti-inflammatory drugs (NSAIDs) differ in their relative specificities for COX-2 and COX-1; while ...
Mouth ulcer
... non-steroidal anti-inflammatory drugs, nicorandil[11] (may be prescribed for angina) and propylthiouracil (e.g. used for ... Agent. Example(s) Viral. chickenpox, hand, foot and mouth disease, herpangina, herpetic stomatitis, human immunodeficiency ... Phenol is used during dental treatment as a cavity sterilizing agent and cauterizing material, and it is also present in some ... Numerous aphthous ulcers could be indicative of an inflammatory autoimmune disease called Behçet's disease. This can later ...
Anti-inflammatory
More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... "Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis". British Medical Journal (Clinical ... Nonsteroidal anti-inflammatory drugsEdit. Nonsteroidal anti-inflammatory drugs (NSAIDs) alleviate pain by counteracting the ... "List of 63 Anti-Inflammatory Foods to Choose from for Natural Healing". The Natural Anti-Inflammatory Remedies. Retrieved ...
Anesthesia
On-demand pain medications typically include either opioid or non-steroidal anti-inflammatory drugs but can also make use of ... and inhalational anesthetic agents. For more invasive surgery, monitoring may also include temperature, urine output, blood ... as well as for accumulation of exhaled inhalational anesthetic agents, which might be deleterious to the health of operating ...
COVID-19, ang malayang ensiklopedya
"FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19". Drug Safety and Availability (sa ... International Journal of Antimicrobial Agents (sa wikang Ingles). 55 (3): 105924. doi:10.1016/j.ijantimicag.2020.105924. ISSN ... "Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents". The Journal of Hospital ...
Alzheimer's disease
Long-term usage of non-steroidal anti-inflammatory drugs (NSAIDs) were thought in 2007 to be associated with a reduced ... Another similar agent is bapineuzumab, an antibody designed as identical to the naturally induced anti-amyloid antibody.[260] ... effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology". CNS & Neurological Disorders Drug Targets. ... Memantine is a noncompetitive NMDA receptor antagonist first used as an anti-influenza agent. It acts on the glutamatergic ...
Indometatsiin - Vikipeedia
Indometatsiin on mittesteroidsete põletikuvastaste ainete (MSPVA, inglise keeles non-steroidal anti-inflammatory drug ehk NSAID ... A New Non-steroid Anti-inflammatory Agent". Br Med J 2 (5363): 965-70. PMC 1873102. PMID 14056924. doi:10.1136/bmj.2.5363.965. ...
Copper peptide GHK-Cu
Because of the anti-inflammatory properties, copper-peptides could replace corticosteroids or non-steroidal anti-inflammatory ... In the late 1980s, copper peptide GHK-Cu started attracting attention as a promising wound healing agent. Pioneers in this ... GHK peptide has anti-inflammatory properties. Even though an exact mechanism remains unclear, in a recent study GHK and its ... antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and ...
Polyestradiol phosphate
PEP may impair the effects of fibrates (e.g., bezafibrate) and certain nonsteroidal anti-inflammatory drugs (e.g., phenazone)[1 ... Steroidal: Alfatradiol. *Certain androgens/anabolic steroids (e.g., testosterone, testosterone esters, methyltestosterone, ... it very slowly releases the active agent estradiol over at least several months.[20][7] ... Treatment with estrogen has the highest incidence of gynecomastia, at 40 - 80%, anti-androgens, including flutamide, ...
Peptic ulcer and non-steroidal anti-inflammatory agents. | Gut
Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and ... was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of ... associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. ...
Emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology | British Journal of Ophthalmology
Fulminating necrotizing fasciitis after intramuscular injection of a corticoid. Contributing role of non-steroidal anti...
Influence of protein deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti...
... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ...
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti...
... while they preserve or augment their anti-inflammatory activity, thus addressing significant risk factors for atherogenesis. ... Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), α-lipoic acid and indole-3-acetic acid with thiomorpholine were ... Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti- ... of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory ...
A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory...
... application to the study of non-steroidal antiinflammatory agents. by Clyde A Takeguchi et al. ... 2,6-Di-tert-butyl-4-(2′-thenoyl)phenol(R-830): A novel nonsteroidal anti-inflammatory agent with antioxidant properties. * ... application to the study of non-steroidal antiinflammatory agents.. *. Clyde A Takeguchi, Charles J. Sih ... Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes.. *Christian ...
EP 2329849 A1 - Combination Of Alpha-2 Adrenergic Receptor Agonist And Non-steroidal Anti-inflammatory Agent For Treating Or...
Anti-Inflammatory Agents, Non-Steroidal | ISHAR Online
OBJECTIVE: To assess the effectiveness of conservative therapy in carpal tunnel syndrome. DATA SOURCES: A computer-aided search of MEDLINE and the Cochrane Collaboration was conducted for randomized controlled trials (RCTs) from January 1985 to May 2006. REVIEW METHODS: RCTs were included if: (1) the patients, with clinically and electrophysiologically confirmed carpal tunnel syndrome, had not previously undergone surgical release, (2) the efficacy of one or more conservative treatment options was evaluated, (3) the study was designed as a randomized controlled trial ...
Temat: 'Anti-Inflammatory Agents, Non-Steroidal' - OpacWWW - Prolib Integro
Anti. -. Inflammatory. Agents. , Non. -. Steroidal. */adverse effects Anti. -. Inflammatory. Agents. , Non. -. Steroidal. */ ... Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /adverse effects ; Anti. -. Inflammatory. Agents. , Non. -. Steroidal. / ... Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /chemistry ; Anti. -. Inflammatory. Agents. , Non. -. Steroidal. / ... Anti. -. Inflammatory. Agents. /*adverse effects Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /*adverse effects ...
Adapalene
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Anti-Inflammatory Agents, Non-Steroidal, Dermatologic Agents, ATC:D10AD03
Amodiaquine
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Amebicides, Anti-Inflammatory Agents, Non-Steroidal, Antimalarials, ATC:P01BA06
LISINOPRIL TABLETS, USPRx only
Non-steroidal Anti-inflammatory Agents: In some patients with comprised renal function who are being treated with non-steroidal ... Other Agents: Lisinopril has been used concomitantly with nitrates and/or digoxin without evidence of clinically significant ... Agents Increasing Serum Potassium: Lisinopril attenuates potassium loss caused by thiazide-type diuretics. Use of lisinopril ... anti-inflammatory drugs, the co-administration of lisinopril may result in further deterioration of renal function. These ...
DailyMed - LISINOPRIL- lisinopril tablet
Non-Steroidal Anti-Inflammatory Agents In a study in 36 patients with mild to moderate hypertension where the antihypertensive ... 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) 7.4 Dual Blockade ... 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who ... Hypoglycemia: Tell diabetic patients treated with oral antidiabetic agents or insulin starting an ACE inhibitor to monitor for ...
Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study. - PubMed...
Anti-Inflammatory Agents, Non-Steroidal. LinkOut - more resources. Full Text Sources. *Wiley ... Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study.. Ofori B1 ... Many women take non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain ...
Electronic Health Record (EHR)-Based Intervention for Gastroesophageal Reflux Disease (GERD) and Chronic Non-steroidal Anti...
Anti-Inflammatory Agents. Anti-Inflammatory Agents, Non-Steroidal. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents ... and Chronic Non-steroidal Anti-inflammatory Drug (NSAID) Use. The safety and scientific validity of this study is the ... and for gastroprotection for patients on chronic non-steroidal anti-inflammatory drugs (NSAIDs) at increased risk for upper GI ... nonsteroidal anti-inflammatory drugs. peptic ulcer. Diagnosed GERD. Atypical GERD symptoms. chronic NSAID therapy. Risk for ...
Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti...
Anti-Inflammatory Agents. Lansoprazole. Dexlansoprazole. Anti-Inflammatory Agents, Non-Steroidal. Anti-Ulcer Agents. ... Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Antirheumatic Agents. ... in patients with a history of gastric or duodenal ulcer who require long-term therapy of non-steroidal anti-Inflammatory drug ( ... for the Prevention of Recurrent Gastric or Duodenal Ulcers During Long-term Therapy of Non-steroidal Anti-inflammatory Drug ( ...
A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory...
Anti-Inflammatory Agents, Non-Steroidal. Anti-Inflammatory Agents. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents ... Active Comparator: Non-steroidal Anti-inflammatory Drug (NSAIDs) Participants will receive fixed dose combination of tramadol ... A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory ... plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants ...
Diclofenac Sodium Topical : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
More Resources for Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical. *Find Lowest Prices on ... How to use Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical. Read the Medication Guide provided by ... List Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical side effects by likelihood and severity. ... What should I know regarding pregnancy, nursing and administering Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents ...
Asacol HD (Mesalamine Delayed-Release Tablets, Oral): Side Effects, Interactions, Warning, Dosage & Uses
Nephrotoxic Agents, Including Non-Steroidal Anti-Inflammatory Drugs. The concurrent use of mesalamine with known nephrotoxic ... agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of renal reactions [see WARNINGS AND ... releasing mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon. Mesalamine (also ... as active inflammatory bowel disease is also associated with adverse pregnancy outcomes. ...
Delzicol (Mesalamine Delayed-Release Capsules): Side Effects, Interactions, Warning, Dosage & Uses
Nephrotoxic Agents, Including Non-Steroidal Anti-Inflammatory Drugs. The concurrent use of mesalamine with known nephrotoxic ... agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of renal reactions [see WARNINGS AND ... which dissolves at pH 7 or greater and releases mesalamine in the terminal ileum and beyond for topical anti-inflammatory ... as active inflammatory bowel disease is also associated with adverse pregnancy outcomes. ...
Non-steroidal anti-inflammatory a... preview & related info | Mendeley
Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. ... Grabosch, S. M., Shariff, O. M., Wulff, J. L., & Helm, C. W. (2014, April 9). Non-steroidal anti-inflammatory agents to induce ... Objectives: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including ...
Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory agents. | IMSEAR
Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory agents. ... Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory age ... Anti-Inflammatory Agents Language: English Year: 1985 Type: Article ... Anti-Inflammatory Agents Language: English Year: 1985 Type: Article ...
Micardis HCT - FDA prescribing information, side effects and uses
Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors. Telmisartan. Non-Steroidal Anti- ... Administration of a non-steroidal anti-inflammatory agent, including a selective COX‑2 inhibitor, can reduce the diuretic, ... Therefore, when MICARDIS HCT and non-steroidal anti-inflammatory agents including selective COX‑2 inhibitors are used ... aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). *potassium supplements or a salt substitute containing ...
WHO HQ Library catalog ›
Results of search for 'su:{Anti-inflammatory agents, Non-steroidal}'
Side Effects of Accupril (quinapril): Interactions & Warnings
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who are ... Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effects of ACE inhibitors. ... Other Agents. Drug interaction studies of Accupril with other agents showed:. *Multiple dose therapy with propranolol or ... Agents That Inhibit mTOR. Patients taking concomitant mTOR inhibitor (e.g. temsirolimus) therapy may be at increased risk for ...
Side Effects of Mavik (trandolapril): Interactions & Warnings
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who are ... Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effects of Mavik. ... Antidiabetic Agents. Concomitant use of ACE inhibitors and antidiabetic medicines (insulin or oral hypoglycemic agents) may ... Agents Increasing Serum Potassium. Trandolapril can attenuate potassium loss caused by thiazide diuretics and increase serum ...
Olmesartan Medoxomil - FDA prescribing information, side effects and uses
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who are ... Agents Increasing Serum Potassium. Concomitant use of olmesartan with other agents that block the renin-angiotensin system, ... Bile Acid Sequestering Agent Colesevelam. Concomitant administration of 40 mg Olmesartan Medoxomil and 3750 mg colesevelam ... Closely monitor blood pressure, renal function and electrolytes in patients on Olmesartan Medoxomil and other agents that ...
Non-Steroidal Anti-Inflammatory Drugs NSAIDs | GreenMedInfo | Toxic
This topic contains 105 study abstracts on Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) indicating it may contribute to ... Anti-Inflammatory Agents. Additional Keywords : Natural Substances Versus Drugs. Problem Substances : Non-Steroidal Anti- ... 21 Adverse Pharmacological Actions Researched for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Name. AC. CK. Focus. ... 4 Abstracts with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) & Rheumatoid Arthritis Research. [x] Remove Focus on Rheumatoid ...
Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal...
To evaluate this traditional medicinal effect, we investigated the anti-chronic infl … ... Keywords: Anti-chronic inflammatory activity; Cellular senescence; Homoisoflavone; Ophiopogon japonicus; SASP; Steroidal ... Anti-Inflammatory Agents / pharmacology * Anti-Inflammatory Agents / therapeutic use* * Cellular Senescence / drug effects* ... Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal ...
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Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft...
Jones P, Lamdin R, Dalziel SR Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft ... The best drug treatment for such injuries is not certain, although non-steroidal anti-inflammatory drugs (NSAIDs) are often ... The applicability of findings from these studies is in question because the dextropropoxyphene combination analgesic agents ...
NSAIDsDrugsTopicalNSAIDAnalgesicCytokinesMediatorsAspirinIbuprofenRheumatoid ArthritisPharmacologicalInhibitRatsMedicinal ChemistryMedicationsCombination with other antihypertensive agentsCompositionsAntihypertensive agentsInduceMicrovascularDrugPeptic ulcerDerivativesAcetaminophenPharmacologyClinicalTherapeuticReceptorsEffectsAcuteResponsesActivityPharmaceuticalComprisesStudy
NSAIDs31
- Many women take non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain controversial. (nih.gov)
- The purpose of the study is to examine the impact of augmented, high-quality physician-coordinated care executed via an electronic health record (EHR)-based intervention on quality of care for gastroesophageal reflux disease (GERD) and for gastroprotection for patients on chronic non-steroidal anti-inflammatory drugs (NSAIDs) at increased risk for upper GI tract ulcers and ulcer related complications. (clinicaltrials.gov)
- The purpose of this study is to compare the effectiveness of tramadol hydrochloride 37.5 milligram (mg) plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants with knee osteoarthritis (a progressive and degenerative joint disease, in which the joints become painful and stiff) whose pain was relieved after the add-on treatment of tramadol hydrochloride to NSAIDs. (clinicaltrials.gov)
- Objectives: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, to induce regression and prevent the progression of cervical intraepithelial neoplasia CIN. (mendeley.com)
- Aspirin and other nonsteroidal anti-inflammatory drugs ( NSAIDs ) may reduce the effects of ACE inhibitors. (medicinenet.com)
- Exposure to non-steroidal anti-inflammatory drugs (NSAIDs) is known to increase substantially the risk of upper gastrointestinal bleeding and perforation (UGIB). (nih.gov)
- The present study was designed to investigate human gastric blood flow during administration of non-steroidal anti-inflammatory drugs (NSAIDs) by harmonic flash echo imaging. (biomedsearch.com)
- The best drug treatment for such injuries is not certain, although non-steroidal anti-inflammatory drugs (NSAIDs) are often recommended. (painpluscpn.ca)
- The present invention relates generally to pharmaceutical preparations and medical treatment methods, and more particularly agents (i.e, urea and urea derivatives, nonsteroidal anti-inflammatory drugs (NSAIDS) and anti-metabolite drugs) used alone or in combinations with each other (or with other agents) to treat or prevent certain disorders of the eye. (google.com.au)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), both nonselective and cyclooxygenase-2-specific inhibitors, are commonly used medications for the relief of acute and chronic pain associated with a wide range of medical conditions. (nih.gov)
- We also reviewed the literature to assess the risks and effectiveness of nonsteroidal anti-inflammatory drugs (NSAIDs), which are often used as the "conventional" first-line treatment for similar musculoskeletal conditions. (chiro.org)
- Background: Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). (eurekaselect.com)
- Background Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of heart failure. (bmj.com)
- Introduction: Currently, the diagnosis of nonsteroidal antiinflammatory drugs (NSAIDs) hypersensivitity is based on patients´ clinical history and drug provocation tests, which are done in selected cases. (usp.br)
- Conditions › Back Pain › Low Back Pain › Non-steroidal Anti-inflammatory Drugs (NSAIDs) in the Treatm. (spineuniverse.com)
- Aspirin is the prototypical member of the group of medications known as non-steroidal anti-inflammatory drugs (NSAIDs) . (spineuniverse.com)
- A reduction in their local concentration could therefore explain the combined anti-inflammatory and analgesic properties of NSAIDs. (spineuniverse.com)
- Most NSAIDs do not decrease the production of lipoxygenase-produced leukotrienes (causes inflammation and allergic reactions), which are also believed to significantly contribute to the inflammatory response. (spineuniverse.com)
- A disparity between the anti-inflammatory and analgesic potencies of these agents in clinical practice has been observed, and recent data has suggested that pain relief from NSAIDs may in part be secondary to a more central anti-nociceptive component. (spineuniverse.com)
- With the recently expanded sales and marketing of over-thecounter ibuprofen and naproxen, additional increases in the already widespread use of nonsteroidal antiinflammatory drugs (NSAIDs) [3] is likely. (thefreelibrary.com)
- With the exception of acetaminophen and tramadol, the above analgesics, also classified as NSAIDs, are indicated for the treatment of acute or chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute pericarditis, and Kawasaki's disease. (thefreelibrary.com)
- The most common causes are bacteria and use of nonsteroidal anti-inflammatory drugs ( NSAIDs ). (medicalnewstoday.com)
- Epidemiological studies suggest reduced AD risk associates with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). (jneurosci.org)
- ABSTRACT: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and consumed drug classes, they are associated with a wide range of adverse effects, including NSAID-induced hypersensitivity reactions (NHRs). (uspharmacist.com)
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used analgesic, anti-inflammatory, and antipyretic medications on the market. (uspharmacist.com)
- To evaluate the effect of the topical steroid, fluorometholone, and the non-steroidal anti-inflammatory drugs (NSAIDs), nepafenac and ketorolac, on inflammatory cytokine expression of the ocular surface in the botulium toxin B-induced murine dry eye model. (molvis.org)
- Topical fluorometholone caused suppression of inflammatory cytokine expression on the ocular surface in the Botulium toxin B-induced murine dry eye model, while topical NSAIDs demonstrated no clearly beneficial effects. (molvis.org)
- Several epidemiological studies have demonstrated a reduced risk for AD in patients using nonsteroidal anti-inflammatory drugs (NSAIDs), prompting further inquiries about how NSAIDs might influence the development of AD pathology and inflammation in the CNS. (jneurosci.org)
- Background NSAIDs are popular and used as analgesics, antipyretics and anti-inflammatory agents for more than a century. (bmj.com)
- CSIs are equivalent to non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory agents. (mja.com.au)
- are they safer than non-steroidal anti-inflammatory drugs (NSAIDs) in patients with hypertension and renal impairment? (mja.com.au)
Drugs21
- Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity. (semanticscholar.org)
- Association of Aspirin and Other Nonsteroidal Anti - inflammatory Drugs With Vertebral Trabecular Bone: Data From Multiethnic Study of Atherosclerosis, a Population-Based Multicenter Cohort Study. (wroc.pl)
- Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study. (nih.gov)
- Nonsteroidal anti-inflammatory drugs (including diclofenac ) may rarely increase the risk for a heart attack or stroke . (webmd.com)
- Some nonsteroidal antiinflammatory drugs can significantly increase C-reactive protein levels. (greenmedinfo.com)
- Reduced conscious blood flow in the stomach during non-steroidal anti-inflammatory drugs administration assessed by flash echo imaging. (biomedsearch.com)
- Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. (painpluscpn.ca)
- Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. (springer.com)
- The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. (cancer.gov)
- Many drugs are available in the market for inflammatory diseases. (hindawi.com)
- Inflammatory diseases are mainly treated with nonsteroidal anti-inflammatory drugs and steroidal drugs [ 1 ]. (hindawi.com)
- To estimate peptic ulcer prevalence in 10 years-interval and compare the association with H. pylori and use of non-steroidal anti-inflammatory drugs. (scielo.br)
- Records assessment in two periods: A (1997-2000) and B (2007-2010), searching for peptic ulcer, H. pylori infection and non-steroidal anti-inflammatory drugs use. (scielo.br)
- Peptic ulcer occurred in 30.35% in A and in 20.19% in B. H. pylori infection occurred in 73.3% cases in A and in 46.4% in B. Non-steroidal anti-inflammatory drugs use was 3.5% in A and 13.3% in B. Neither condition occurred in 10.4% and 20.5% in A and B respectively. (scielo.br)
- Comparing both periods, we observed reduction of peptic ulcer associated to H. pylori ( P =0.000), increase of peptic ulcer related to non-steroidal anti-inflammatory drugs ( P =0.000) and idiopathic peptic ulcer ( P =0.002). (scielo.br)
- The concurrent association of H. pylori and non-steroidal anti-inflammatory drugs was also higher in B ( P =0.002). (scielo.br)
- After 10 years, the prevalence of peptic ulcer decreased, as well as ulcers related to H. pylori whereas ulcers associated to non-steroidal anti-inflammatory drugs increased. (scielo.br)
- Analgesic drugs comprise the largest category of pharmaceutical agents consumed by individuals in the United States. (thefreelibrary.com)
- One major concern is that the analgesic class of drugs accounted for more exposures reported to the American Association of Poison Control Centers in 1995 than did any other category of pharmaceutical agents (3). (thefreelibrary.com)
- Side effect issues could be overcome using alternative anti-inflammatory drugs directed against different inflammatory targets. (jneurosci.org)
- The availability of the COX-2-specific inhibitor (CSI) class of anti-inflammatory drugs, namely celecoxib and rofecoxib, has raised a number of questions. (mja.com.au)
Topical5
- The inner coat consists of an acrylic based resin, Eudragit S, which dissolves at pH 7 or greater, releasing mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon . (rxlist.com)
- DELZICOL (mesalamine) delayed-release capsules contain acrylic based resin, Eudragit S (methacrylic acid copolymer type B, NF), which dissolves at pH 7 or greater and releases mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon . (rxlist.com)
- Pre-operative use of the topical steroidal and non-steroidal anti-inflammatory agents to maintain intra-operative mydriasis during cataract surgery. (bvsalud.org)
- This paper summarizes the currently accepted concepts of the pathogenetic mechanisms underlying the morphological and functional changes in intranasal mucosa of the patients having a long history of the application of the long-acting topical vasoconstrictor agents. (bireme.br)
- This current study was designed to investigate whether topical fluorometholone, ketorolac and nepafenac inhibit inflammatory cytokine expression on the ocular surface in the BTX-B-induced murine dry eye model. (molvis.org)
NSAID4
- Diclofenac is known as a nonsteroidal anti-inflammatory drug (NSAID). (webmd.com)
- The dosing and cost of each NSAID varies significantly by chemical family and agent. (spineuniverse.com)
- The present invention is directed to a pharmaceutical composition and method for the treatment of rhinitis and cold-like symptoms which includes a non-steroidal anti-inflammatory drug (NSAID), a decongestant, and an antihistamine. (google.com)
- It has been found that an NSAID enhances the activity of a decongestant and an anti-histamine, thus permitting a reduction in either or both in administration of separate dosage forms. (google.com)
Analgesic2
- The applicability of findings from these studies is in question because the dextropropoxyphene combination analgesic agents used are no longer in general use. (painpluscpn.ca)
- Have analgesic, anti-inflammatory, and antipyretic activities. (medscape.com)
Cytokines4
- Synergistic enhancement of production of proinflammatory cytokines of human peripheral blood monocytes by anti-Sm and anti-RNP antibodies. (bioportfolio.com)
- In our previous study, the oxLDL/βGPI/anti-βGPI complex was demonstrated to further enhance the foam cell formation and migration of VSMC, as well as the expression of inflammatory cytokines, via th. (bioportfolio.com)
- The pro-inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were evaluated by immunohistochemistry. (molvis.org)
- The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits. (jneurosci.org)
Mediators5
- During an inflammatory response, mediators such as various inflammatory mediators are released into the rat paw tissue, such as prostaglandins (PGE2), leukotrienes (LTD4), nitric oxide (NO), and oxygen reactive species. (hindawi.com)
- These inflammatory mediators have potential to continue stimulating the inflammatory response and its perpetuation [ 2 ]. (hindawi.com)
- These events are induced by inflammatory mediators which bind to specific receptors on inflammatory and endothelial cells. (hindawi.com)
- Prostaglandins are active mediators of the inflammatory cascade, which also serve to sensitize peripheral nociceptors (nerve endings). (spineuniverse.com)
- COX-1 inhibition shifts the arachidonic acid pathway from the production of the protective anti-inflammatory prostaglandins toward the production of the proinflammatory mediators, eosinophils, and mast cells. (uspharmacist.com)
Aspirin3
- Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. (bmj.com)
- There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. (bmj.com)
- The most common antiplatelet agent prescribed is a small dose of aspirin (Aspec®, Cartia®, Cardiprin® and others). (dermnetnz.org)
Ibuprofen5
- Anti-inflammatory doses of ibuprofen: effect on neutrophils and exercise-induced muscle injury. (biomedsearch.com)
- The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2* production, and markers of muscle injury. (biomedsearch.com)
- In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise. (biomedsearch.com)
- Ibuprofen also decreased the numbers of ubiquitin-labeled dystrophic neurites and the percentage area per plaque of anti-phosphotyrosine-labeled microglia. (jneurosci.org)
- Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD. (jneurosci.org)
Rheumatoid Arthritis1
- Sulfasalazine (SSZ) is a commonly used drug in the treatment of inflammatory diseases such as rheumatoid arthritis and Crohn's disease. (tudelft.nl)
Pharmacological2
- Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. (pharmacycode.com)
- Induction of TH typically requires a multimodal approach, including the use of both pharmacological agents and physical techniques. (frontiersin.org)
Inhibit1
- Antiplatelet agents inhibit the production of thromboxane. (dermnetnz.org)
Rats3
- Influence of protein deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in rats. (aspetjournals.org)
- In the present study, we examined the anti-inflammatory effects of dried fruit methanol extract on carrageenan-induced hind paw edema in rats. (hindawi.com)
- Diosgenin Protects Rats from Myocardial Inflammatory Injury Induced by Ischemia-Reperfusion. (bioportfolio.com)
Medicinal Chemistry1
- Each issue of Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry affords the reader with timely reviews on current topics, which are invaluable to those engaged in particular areas of research and those wanting to update their knowledge in areas outside of their expertise. (benthamscience.com)
Medications1
- Because of the extensive use of these agents, adverse events that occur infrequently may still affect the overall risk/benefit ratio of this class of medications. (nih.gov)
Combination with other antihypertensive agents2
- Micardis HCT may be used alone or in combination with other antihypertensive agents. (drugs.com)
- Captopril is effective alone and in combination with other antihypertensive agents, especially thiazide -type diuretics . (wikidoc.org)
Compositions1
- Topically applicable compositions in the form of oil-in-water (O/W) emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable emulsifying system and at least one active agent of the family of steroidal anti-inflammatory agents, and are useful e.g., for the treatment of psoriasis. (freepatentsonline.com)
Antihypertensive agents1
- Olmesartan may be administered with other antihypertensive agents. (wikidoc.org)
Induce1
- These proinflammatory agents can then induce the overproduction of cysteinyl leukotrienes (CysLTs), which causes an increase of CysLTs receptor expression in the bronchial muscles, as well as the endothelial and epithelial cells. (uspharmacist.com)
Microvascular1
- Acute rat paw inflammation is caused by the migration of inflammatory cells into the microvascular system and fluid entering the interstitial tissue. (hindawi.com)
Drug7
- 10. The drug delivery device of claim 5 wherein said body is impermeable to said pharmaceutically active agent. (google.de)
- 12. The drug delivery device of claim 5 wherein said inner core comprises a semi-solid form, and said pharmaceutically active agent is disposed within said semi-solid form. (google.de)
- 15. The drug delivery device of claim 1 wherein said pharmaceutically active agent is nepafenac. (google.de)
- 17. The drug delivery device of claim 1 wherein said pharmaceutically active agent comprises eliprodil. (google.de)
- The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. (springer.com)
- 3. The resorbable drug delivery system of claim 1, wherein the binding agent is a hydrolyzed collagen or hydrolyzed elastin of a molecular weight of about 2500-4000. (google.com.au)
- The anti-inflammatory activity of the methanol extract of the dried fruits shows that the presence of potential constituents present in this extract may provide assistance in the drug discovery process. (hindawi.com)
Peptic ulcer1
- Peptic ulcer and non-steroidal anti-inflammatory agents. (bmj.com)
Derivatives1
- A pilot study to examine the effects of an anti-inflammatory supplement on eicosanoid derivatives in patients with chronic kidney disease. (greenmedinfo.com)
Acetaminophen1
- Tylenol (acetaminophen) is not an anti-inflammatory medicine and is not likely to help. (wikihow.com)
Pharmacology1
- Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory agents. (bvsalud.org)
Clinical2
- Check for active clinical trials using this agent. (cancer.gov)
- Anti-inflammatory therapy may be beneficial for dry eye treatment which has been reported in a series of animal and clinical trials. (molvis.org)
Therapeutic3
- 12. A method according to claim 1 wherein said agent is delivered into the posterior segment of the eye by initially administering the agent to the anterior segment of the eye in a form and dose that is sufficient to cause a therapeutic amount of the agent to distribute to the posterior segment. (google.com.au)
- The objective of this study is to assess whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET-CT could be an early predictive method of therapeutic response to anti-PD-1 imm. (bioportfolio.com)
- New therapeutic agents provide interesting new options for Patienten with difficult-to-treat gouty arthritis. (springer.com)
Receptors1
- 3. Use according to either of the preceding claims, characterized in that the bradykinin antagonist is chosen from optionally modified, natural or synthetic peptides, natural or synthetic chemical molecules, antisense nucleic acids, ribozymes, anti-bradykinin antibodies, soluble bradykinin receptors, anti-bradykinin-receptor antibodies or bradykinin receptor antagonists. (freepatentsonline.com)
Effects8
- Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes. (semanticscholar.org)
- A number of studies report anti-inflammatory effects from Zeel. (isharonline.org)
- Anti-arrhythmogenic and anti-inflammatory effects of troxerutin in ischemia/reperfusion injury of diabetic myocardium. (bioportfolio.com)
- Anti-proliferation and anti-metastatic effects of sevoflurane on human osteosarcoma U2OS and Saos-2 cells. (bioportfolio.com)
- To sum up, our results evidenced that sevoflurane exerted anti-proliferative and anti-metastatic effects on osteosarcoma cells by inactivating PI3K/AKT pathway. (bioportfolio.com)
- Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with Capecitabine (Cap) and/or Irinoteca. (bioportfolio.com)
- The biphasic effects of the oxLDL/βGPI/anti-βGPI complex on VSMC proliferation and apoptosis. (bioportfolio.com)
- Resveratrol: Review on its discovery, pharmacokinetics and anti-leukemia effects. (bioportfolio.com)
Acute1
- Experimental model of carrageenan-induced acute inflammation produces a range of inflammatory responses, due to the increase in the response to chemoattractants increasing PMN migration to the sites of inflammation [ 3 ]. (hindawi.com)
Responses1
- The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during is. (bioportfolio.com)
Activity2
- A murine IgG1 monoclonal anti-idiotype antibody, containing a variable antigen-binding region that functionally mimics the three-dimensional structure of a specific epitope on the ovarian cancer tumor-associated antigen CA-125, with potential antineoplastic activity. (cancer.gov)
- However, its anti-metastatic activity rem. (bioportfolio.com)
Pharmaceutical3
- 1. A topically applicable, physically and chemically stable pharmaceutical composition comprising an oil-in-water emulsion which contains: a. at least one steroidal anti-inflammatory agent, b. a pro-penetrating system which comprises at least one glycol and at least one additional pro-penetrating agent, c. at least one polymeric emulsifier other than an acrylate/C10-30 alkyl acrylate copolymer, formulated into a topically applicable, pharmaceutically acceptable vehicle therefor. (freepatentsonline.com)
- 2. The pharmaceutical composition/oil-in-water emulsion as defined by claim 1, said at least one steroidal anti-inflammatory agent comprising hydrocortisone, an anthranoid, betamethasone valerate and/or clobetasol propionate. (freepatentsonline.com)
- 4. The pharmaceutical composition/oil-in-water emulsion as defined by claim 1, said at least one pro-penetrating glycol being selected from the group consisting of a C1 to C6 alkylene or polyalkylene glycol and a glycol ether, and the at least one additional pro-penetrating agent being a glycol or a pro-penetrating agent selected from the family of fatty esters, fatty acids or fatty alcohols, or alcohols. (freepatentsonline.com)
Comprises4
- A. delivering into the posterior segment of the eye a therapeutically effective amount of an agent that comprises urea or a urea derivative or mixtures thereof. (google.com.au)
- 5. A method according to claim 3 wherein the agent delivered in Step A comprises 30 micrograms-7500 micrograms of urea per 50 micro liters to 100 microliters of solution. (google.com.au)
- 10. A method according to claim 1 wherein the agent delivered in Step A comprises approximately 300 micrograms of urea per 50 microliters of solution. (google.com.au)
- A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C2-16 α-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin. (google.com.au)
Study4
- A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory agents. (semanticscholar.org)
- This study was designed to investigate anti-arrhythmic and anti-inflammatory po. (bioportfolio.com)
- The present study was performed to elucidate the roles of serum anti-Sm antibodies in the pathogenesis of systemic lupus erythematosus (SLE). (bioportfolio.com)
- This is an open label, single-arm, phase IB treatment study to determine the safety of administering anti-PD1 monoclonal antibodies with AV-MEL-1 and to get some suggestion of efficacy, in. (bioportfolio.com)