AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, Agriculture
Anti-Inflammatory Agents, Non-SteroidalInflammationOkadaic AcidLipopolysaccharidesTranscription Factor RelATumor Necrosis Factor-alphaInflammation MediatorsI-kappa B KinaseI-kappa B ProteinsNF-kappa BInterleukin-1SteroidsTetradecanoylphorbol AcetateMacrophagesCells, CulturedSpirostansGene Expression RegulationSaponinsGlycosidesDiosgeninTomatineLiliaceaeSolanaceous AlkaloidsChlormadinone AcetateMolecular StructurePregnanesCynanchumAndrostanesEstrogen AntagonistsRhizomeMagnetic Resonance SpectroscopyDracaenaSmilaxBuxaceaeSolanumDioscoreaAlliumAromatase InhibitorsWithanolidesPlant ExtractsTestolactoneHolarrhenaEstradiolAnemarrhenaHydroxysteroidsStereoisomerismMolecular ConformationAsparagus PlantSpectrometry, Mass, Fast Atom BombardmentSolanum nigrumAlveolectomyAndrostenesWithaniaAgaveOphiopogonChloroquinolinolsTrilliumTropaeolaceaeGestrinonePhytosterolsHemolytic AgentsConvallariaAndrostanolsMarsdeniaSolanaceaeAgavaceaeFritillariaEstrogensPregnenesVeratrumHostaCyproterone AcetateSolanineSubgingival Curettage
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Okadaic Acid
A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)
Lipopolysaccharides
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Transcription Factor RelA
A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Inflammation Mediators
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
I-kappa B Kinase
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
I-kappa B Proteins
A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.
NF-kappa B
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
Interleukin-1
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
Steroids
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Tetradecanoylphorbol Acetate
A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Spirostans
Cholestane derivatives containing a fused lactone ring at the 16,17-position and a spiroglycosidic linkage at C-22. Members include sarsaponin, DIOSGENIN and yamogenin.
Gene Expression Regulation
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Saponins
A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Diosgenin
A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.
Tomatine
An alkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. (From The Merck Index, 11th ed)
Liliaceae
A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.
Solanaceous Alkaloids
Alkaloids, mainly tropanes, elaborated by plants of the family Solanaceae, including Atropa, Hyoscyamus, Mandragora, Nicotiana, Solanum, etc. Some act as cholinergic antagonists; most are very toxic; many are used medicinally.
Chlormadinone Acetate
An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.
Molecular Structure
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Pregnanes
Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.
Cynanchum
A plant genus of the family ASCLEPIADACEAE. Members contain steroidal glycosides and cytotoxic phenanthroindolizidine N-oxide alkaloids.
Androstanes
The family of steroids from which the androgens are derived.
Estrogen Antagonists
Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.
Rhizome
Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.
Magnetic Resonance Spectroscopy
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Dracaena
A plant genus of the family LILIACEAE. The common name of "dragon's blood" is also used for CROTON and Daemonorops (ARECACEAE).
Smilax
A plant genus of the family SMILACACEAE. Members contain smiglasides (phenylpropanoid glycosides) and steroidal saponins. Commercially it is sometimes adulterated with HEMIDESMUS, which would affect experimental results.
Buxaceae
A plant family of the order Euphorbiales, subclass Rosidae, class Magnoliopsida. Leaves are alternate, simple, and leathery. Fruits are one- or two-seeded capsules or drupes (stony-pitted fleshy fruits).
Solanum
A plant genus of the family SOLANACEAE. Members contain SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for ATROPA BELLADONNA.
Dioscorea
A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.
Allium
A genus of the plant family Liliaceae (sometimes classified as Alliaceae) in the order Liliales. Many produce pungent, often bacteriostatic and physiologically active compounds and are used as VEGETABLES; CONDIMENTS; and medicament, the latter in traditional medicine.
Aromatase Inhibitors
Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.
Withanolides
Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.
Plant Extracts
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Testolactone
An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.
Holarrhena
A plant genus of the family APOCYNACEAE. Members contain holarrhenine (a steroidal alkaloid) and TRICHOTHECENES.
Estradiol
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
Anemarrhena
A plant genus of the family LILIACEAE. Members contain anemarans (POLYSACCHARIDES), hinokiresinol, mangiferin (a xanthone), and timosaponin (a steroidal saponin).
Hydroxysteroids
Steroids in which one or more hydroxy groups have been substituted for hydrogen atoms either within the ring skeleton or on any of the side chains.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Molecular Conformation
The characteristic three-dimensional shape of a molecule.
Asparagus Plant
A plant genus in the family LILIACEAE (sometimes placed in Asparagaceae) that contains ECDYSTEROIDS and is an ingredient of Siotone. The shoots are used as a vegetable and the roots are used in FOLK MEDICINE.
Spectrometry, Mass, Fast Atom Bombardment
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Solanum nigrum
A plant species of the genus SOLANUM, family SOLANACEAE that contains steroidal glycosides.
Alveolectomy
Subtotal or complete excision of the alveolar process of the maxilla or mandible. (Dorland, 28th ed)
Androstenes
Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.
Withania
A plant genus of the family SOLANACEAE. Members contain withanolides. Withania somnifera is the source of ashwagandha and aswal.
Agave
A genus known for fibers obtained from their leaves: sisal from A. sisalana, henequen from A. fourcroyoides and A. cantala, or Manila-Maguey fiber from A. cantala. Some species provide a sap that is fermented to an intoxicating drink, called pulque in Mexico. Some contain agavesides.
Ophiopogon
A plant genus of the family LILIACEAE. Members contain steroidal glycosides and provide an ingredient of shengmaisan (DRUGS, CHINESE HERBAL).
Chloroquinolinols
8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.
Trillium
A plant genus of the family LILIACEAE that is a short plant with a distinct whorl of 3 broad leaves.
Tropaeolaceae
A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.
Gestrinone
A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.
Phytosterols
A class of organic compounds known as STEROLS or STEROIDS derived from plants.
Hemolytic Agents
Substances that are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.
Convallaria
A plant genus of the family LILIACEAE that contains CARDIAC GLYCOSIDES.
Androstanols
Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.
Marsdenia
A plant genus of the family ASCLEPIADACEAE. Members contain pregnane glycosides (marsdekoiside & marstomentosides, maryal) and hainaneosides (SAPONINS).
Solanaceae
A plant family of the order Solanales, subclass Asteridae. Among the most important are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.
Agavaceae
A plant family of the order Liliales, subclass Liliidae, class Liliopsida. Members of the family have narrow, lance-shaped, sometimes fleshy or toothed leaves that are clustered at the base of each plant. Most species have large flower clusters containing many flowers. The fruit is a capsule or berry.
Fritillaria
A plant genus of the family LILIACEAE. Members of this genus produce imperialine, a steroidal alkaloid which acts at muscarinic receptors.
Estrogens
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Pregnenes
Unsaturated derivatives of PREGNANES.
Veratrum
A plant genus of the family LILIACEAE with roots that contain VERATRUM ALKALOIDS used as emetics, parasiticides, antihypertensives. It is the main ingredient of Boicil.
Hosta
A plant genus of the family LILIACEAE. Members contain steroidal saponins.
Cyproterone Acetate
An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.
Solanine
A mixture of alpha-chaconine and alpha-solanine, found in SOLANACEAE plants.
Subgingival Curettage
Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)

Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension. (1/7426)

OBJECTIVE: To investigate the usefulness of hydroxychloroquine (HCQ) dose-loading to increase the percentage of responders or rate of response in treating rheumatoid arthritis (RA). METHODS: Two hundred twelve patients with early RA (mean duration 1.5 years) were enrolled in a 24-week trial. Patients were stabilized with 1,000 mg naproxen/day and then began a 6-week, double-blind trial comparing treatment with HCQ at 400 mg/day (n = 71), 800 mg/day (n = 71), and 1,200 mg/day (n = 66), followed by 18 weeks of open-label HCQ treatment at 400 mg/day. RESULTS: All patients had mild, active disease at the time of initiation of HCQ treatment (31-43% rheumatoid factor positive; no previous disease-modifying antirheumatic drugs; mean swollen joint count 8.6-10.4). Based on the Paulus criteria, response during the 6-week double-blind portion of the study was 47.97%, 57.7%, and 63.6% in the 400 mg/day, 800 mg/day, and 1,200 mg/day groups, respectively (P = 0.052). Discontinuations for adverse events were dose related (3 in the 400 mg/day group, 5 in the 800 mg/day group, 6 in the 1,200 mg/day group). Most involved the gastrointestinal (GI) system, with the background naproxen treatment possibly contributing. Ocular abnormalities occurred in 17 of 212 patients (8%) but were not dose related. CONCLUSION: Dose-loading with HCQ increased the degree of response at 6 weeks in this group of patients with early, predominantly seronegative RA. Adverse GI events were dose related, while adverse ocular events were not.  (+info)

Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. (2/7426)

Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorigenesis. We have examined apoptosis induction by non-steroidal anti-inflammatory drugs (NSAIDs) in human gastric (AGS) cancer cells and the role of protein kinase C (PKC) and apoptosis-related oncogenes. After treatment with aspirin or indomethacin, cell growth was quantified by MTT assay, and apoptosis was determined by acridine orange staining, DNA fragmentation and flow cytometry. The mRNA and protein of p53, p21waf1/cip1 and c-myc was detected by Northern and Western blotting respectively. The influence of PKC on indomethacin-induced apoptosis was determined by co-incubation of 12-O-tetradecanoylphorbol 13-acetate (TPA). The role of c-myc was determined using its antisense oligonucleotides. The results showed that both aspirin and indomethacin inhibited cell growth and induced apoptosis of AGS cells in a dose- and time-dependent manner, without altering the cell cycle. Indomethacin increased c-myc mRNA and protein, whereas p53 and p21wafl/cip1 were unchanged. Down-regulation of c-myc by its antisense oligonucleotides reduced apoptosis induction by indomethacin. TPA could inhibit indomethacin-induced apoptosis and accumulate cells in G2/M. Overexpression of c-myc was inhibited by TPA and p21waf1/cip1 mRNA increased. In conclusion, NSAIDs induce apoptosis in gastric cancer cells which may be mediated by up-regulation of c-myc proto-oncogene. PKC activation can abrogate the effects of NSAIDs by decreasing c-myc expression.  (+info)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (3/7426)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted.  (+info)

Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. (4/7426)

LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7.3 x 10(-6) mole fraction, which approached the stiochiometric limit of this assay. The true potency of LY315920 was defined using a deoxycholate/phosphatidylcholine assay with a mole fraction of 1.5 x 10(-6). LY315920 was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase. Human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells was inhibited by LY315920 with an IC50 of 0.79 microM. The release of TXA2 from these cells by N-formyl-methionyl-leucyl-phenylalanine or arachidonic acid was not inhibited. The i.v. administration of LY315920, 5 min before harvesting the bronchoalveolar lavage cells, resulted in the inhibition of sPLA2-induced production of TXA2 with an ED50 of 16.1 mg/kg. Challenge of guinea pig lung pleural strips with sPLA2 produced contractile responses that were suppressed in a concentration-dependent manner by LY315920 with an apparent KB of 83 +/- 14 nM. Contractile responses induced by arachidonic acid were not altered. Intravenous or oral administration of LY315920 to transgenic mice expressing the human sPLA2 protein inhibited serum sPLA2 activity in a dose-related manner over a 4-h time course. LY315920 is a potent and selective sPLA2 inhibitor and represents a new class of anti-inflammatory agent designated SPI. This agent is currently undergoing clinical evaluation and should help to define the role of sPLA2 in various inflammatory disease states.  (+info)

Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. (5/7426)

The marked analgesic efficacy of ketorolac in humans, relative to other nonsteroidal anti-inflammatory drugs (NSAIDs), has lead to speculation as to whether additional non-NSAID mechanism(s) contribute to its analgesic actions. To evaluate this possibility, we characterized (R,S)-ketorolac's pharmacological properties in vivo and in vitro using the nonselective cyclooxygenase (COX) inhibitors [indomethacin (INDO) and diclofenac sodium (DS)] as well as the selective COX-2 inhibitor, celecoxib, as references. The potency of racemic (R,S)-ketorolac was similar in tests of acetic acid-induced writhing, carrageenan-induced paw hyperalgesia, and carrageenan-induced edema formation in rats; ID50 values = 0.24, 0. 29, and 0.08 mg/kg, respectively. (R,S)-ketorolac's actions were stereospecific, with (S)-ketorolac possessing the biological activity of the racemate in the above tests. The analgesic potencies for (R,S)-, (S)-, and (R)-ketorolac, INDO, and DS were highly correlated with their anti-inflammatory potencies, suggesting a common mechanism. (R,S)-ketorolac was significantly more potent than INDO or DS in vivo. Neither difference in relative potency of COX inhibition for (R,S)-ketorolac over INDO and DS nor activity of (S)-ketorolac at a number of other enzymes, channels, or receptors could account for the differences in observed potency. The distribution coefficient for (R,S)-ketorolac was approximately 30-fold less than for DS or INDO, indicating that (R,S)-ketorolac is much less lipophilic than these NSAIDs. Therefore, the physicochemical and pharmacokinetics properties of (R,S)-ketorolac may optimize the concentrations of (S)-ketorolac at its biological target(s), resulting in greater efficacy and potency in vivo.  (+info)

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (6/7426)

1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent scratching of the injected site with the forepaws and hindpaws. 2. Up to 100 microg of sodium deoxycholic acid induced no significant increase in vascular permeability at the injection site as assessed by a dye leakage method. 3. Bradykinin (BK) B2 receptor antagonists, FR173657 and Hoe140, significantly decreased the frequency of scratching induced by sodium deoxycholic acid. 4. Treatment with aprotinin to inhibit tissue kallikrein reduced the scratching behaviour induced by sodium deoxycholic acid, whereas treatment with soybean trypsin inhibitor to inhibit plasma kallikrein did not. 5. Although injection of kininase II inhibitor, lisinopril together with sodium deoxycholic acid did not alter the scratching behaviour, phosphoramidon, a neutral endopeptidase inhibitor, significantly increased the frequency of scratching. 6. Homogenates of the skin excised from the backs of mice were subjected to gel-filtration column chromatography followed by an assay of kinin release by trypsin from each fraction separated. Less kinin release from the fractions containing kininogen of low molecular weight was observed in the skin injected with sodium deoxycholic acid than in normal skin. 7. The frequency of scratching after the injection of sodium deoxycholic acid in plasma kininogen-deficient Brown Norway Katholiek rats was significantly lower than that in normal rats of the same strain, Brown Norway Kitasato rats. 8. These results indicate that BK released from low-molecular-weight kininogen by tissue kallikrein, but not from high-molecular-weight kininogen by plasma kallikrein, may be involved in the scratching behaviour induced by the injection of sodium deoxycholic acid in the rodent.  (+info)

The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. (7/7426)

To determine whether declining semen quality associated with health problems may be due to certain antibiotic or anti-inflammatory treatments, semen was collected 3 times per week for up to 42 d from 6 normal bulls after treatment with oxytetracycline, tilmicosin, dihydrostreptomycin, or phenylbutazone. No adverse effects on semen quality were observed.  (+info)

Pseudogout attack associated with chronic thyroiditis and Sjogren's syndrome. (8/7426)

A 66-year-old woman, diagnosed with chronic thyroiditis at age 63, presented with anorexia and fatigue. Therapy for the chronic thyroiditis consisted of levothyroxine sodium (100 microg/day). Her symptoms were attributed to the insufficient supply of levothyroxine sodium. Following a dosage increase to 150 microg/day, she suffered from an acute attack of pseudogout. Clinical features were complicated by Sjogren's syndrome, which appeared after treatment onset. Pseudogout was effectively treated by colchicine after administration of diclofenac sodium failed to alleviate the symptoms. Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjogren's syndrome has not been previously reported.  (+info)

Peptic ulcer and non-steroidal anti-inflammatory agents. | GutPeptic ulcer and non-steroidal anti-inflammatory agents. | Gut
Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. By contrast, duodenal ulcer was unrelated to these drugs. Too few patients used paracetamol for any conclusion to be drawn on its role.. ...
http://gut.bmj.com/content/27/8/929
Direct medical costs of serious gastrointestinal ulcers attributable to non steroidal anti-inflammatory drugs in the...Direct medical costs of serious gastrointestinal ulcers attributable to non steroidal anti-inflammatory drugs in the...
TY - CONF. T1 - Direct medical costs of serious gastrointestinal ulcers attributable to non steroidal anti-inflammatory drugs in the Netherlands. AU - Vonkeman, Harald E.. AU - Klok, Rogier M.. AU - Postma, Maarten J.. AU - Brouwers, Jacobus R.B.J.. AU - van de Laar, Mart A.F.J.. PY - 2006/11/10. Y1 - 2006/11/10. N2 - Purpose: The occurrence and prevention of gastrointestinal ulcers attributable to the use of non-steroidal anti-inflammatory drugs (NSAIDs) has become a major health care issue. Analysis of cost effectiveness of preventive strategies has been hampered by a lack of recent cost of illness studies. The aim of this study was to determine direct medical costs of serious gastrointestinal ulcers attributable to NSAIDs from the societal perspectiveMethods: From November 2001 until December 2003 all consecutive patients who were hospitalized due to gastropathy attributable to NSAIDs (serious event) were identified. Data was retrieved on the number of days hospitalized, and on the number and ...
https://research.utwente.nl/en/publications/direct-medical-costs-of-serious-gastrointestinal-ulcers-attributa/
Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)
All information about the latest scientific publications of the Clínica Universidad de Navarra. Hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs)
http://www.cun.es/en/research/scientific-publications/hypersensitivity-to-aspirin-and-other-nonsteroidal-anti-inflammatory-drugs-nsaids
Prescriptions for Cyclooxygenase-2 Inhibitors and Other Nonsteroidal Anti-inflammatory Agents in a Medicaid Managed Care...Prescriptions for Cyclooxygenase-2 Inhibitors and Other Nonsteroidal Anti-inflammatory Agents in a Medicaid Managed Care...
Objective. To determine whether race is a predictor of a patients likelihood of being prescribed selective cyclooxygenase-2 inhibitors (COX-2s) versus other nonsteroidal anti-inflammatory agents (NSAIDs) in Medicaid managed care plans (MCO).. Design. All medical and prescription claims for Medicaid MCO enrollees receiving at least one prescription for a COX-2 or NSAID between January 2000 and June 2002 were retrieved. Selected for study were adults claiming at least one COX-2 prescription or NSAID prescription with a minimum 30 days of supply after June 2000; having 60 total days of supply or more over the study period was also required for study inclusion. The probability of being prescribed a COX-2 was estimated as a logistic function of patient age, gender, race, city/suburban/rural residence, and history of rheumatoid arthritis, osteoarthritis, chronic back pain, acute pains, gastrointestinal problems, use of anticoagulants or corticosteroids, and comorbidities.. Results. Of the 16,868 ...
http://onlinelibrary.wiley.com/doi/10.1111/j.1526-4637.2005.05011.x/full
GastroHep News StoryGastroHep News Story
The relative risk for use of the cyclo-oxygenase-2 inhibitors celecoxib, rofecoxib, and for other non-steroidal anti-inflammatory drugs was assessed.. The doctors identified a total of 3083 cases of acute pancreatitis and 30,830 population controls.. For current use, the relative risk estimate for celecoxib was 1.4, and 1.3 for rofecoxib.. The overall relative risk for other non-steroidal anti-inflammatory drugs was 2.7.. However, the team noted substantial variation in risk between the individual drugs.. The highest relative risk was for diclofenac, and the lowest for naproxen.. Dr Sorensens team concluded, Cyclo-oxygenase-2 selective inhibitors are associated with a lower risk of acute pancreatitis than most other non-steroidal anti-inflammatory drugs. ...
https://www.gastrohep.com/news/news.asp?id=54438
Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs? | The BMJAre selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs? | The BMJ
Selective cyclo-oxygenase 2 (COX 2) inhibitors, including celecoxib (Celebrex) and rofecoxib (Vioxx), are hypothesised to have a lower risk of gastrointestinal complications than traditional non-steroidal anti-inflammatory drugs.1 In September 2000 the celecoxib long term arthritis safety study, better known as CLASS, was published in JAMA.2 This trial, widely cited and distributed, concluded that a COX 2 inhibitor was associated with a lower incidence of complications than traditional non-steroidal anti-inflammatory drugs. What was much less widely publicised were criticisms that contradicted this conclusion.. CLASS was reported as a three arm trial comparing celecoxib 800 mg/day with ibuprofen 2400 mg/day and diclofenac 150 mg/day in osteoarthritis or rheumatoid arthritis. Clinically relevant upper gastrointestinal ulcer complications (bleeding, perforation, or obstruction) and symptomatic ulcers during the first six months of treatment were described as the two main outcome measures, ...
https://www.bmj.com/content/324/7349/1287.full
Safety of meloxicam in patients with aspirin/non-steroidal anti-inflammatory drug-induced urticaria and angioedema | Read by...Safety of meloxicam in patients with aspirin/non-steroidal anti-inflammatory drug-induced urticaria and angioedema | Read by...
It has been proposed that aspirin (ASA) and other non-steroidal anti-inflammatory drug (NSAID)-induced urticaria (UR)/angioedema (AE) are mediated through inhibition of cyclooxygenase-1 (COX-1) enzymes. Therefore, drugs with COX-2 selectivity may be well tolerated in such patients. We investigated the safety of preferential COX-2 inhibitor meloxicam in subjects with UR or AE type intolerance reaction to classical ASA/NSAIDs. Subjects with reliable or documented history of UR/AE due to classical ASA/NSAIDs underwent a single-blinded, placebo-controlled oral challenge with a cumulative dose of 7.5 mg meloxicam on 2 separate days. One-quarter and three-quarter divided doses of placebo and the active drug were given at 1-h intervals. A total of 116 patients (86 women and 30 men, mean age 39.6 ± 12.7 years) were enrolled to the study. The rate of atopy was 25.9%. Mean duration of drug reaction was 87.4 ± 110.8 (1-720) months. Almost half of the patients were multi-reactors. The most comorbid ...
https://read.qxmd.com/read/21039786/safety-of-meloxicam-in-patients-with-aspirin-non-steroidal-anti-inflammatory-drug-induced-urticaria-and-angioedema
Non-steroidal anti-inflammatory drug - wikidocNon-steroidal anti-inflammatory drug - wikidoc
Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs, are drugs with analgesic, antipyretic and anti-inflammatory effects - they reduce pain, fever and inflammation. The term non-steroidal is used to distinguish these drugs from steroids, which (among a broad range of other effects) have a similar eicosanoid-depressing, anti-inflammatory action. As analgesics, NSAIDs are unusual in that they are non-narcotic. NSAIDs are sometimes also referred to as non-steroidal anti-inflammatory agents/analgesics (NSAIAs) or non-steroidal anti-inflammatory medicines (NSAIMs). The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen partly because they are available over-the-counter in many areas. Paracetamol (acetaminophen) has negligible anti-inflammatory activity, and is strictly speaking not an NSAID. Beginning in 1829, with the isolation of salicin from the folk remedy willow bark, NSAIDs have become an important part of the pharmaceutical treatment of pain ...
https://wikidoc.org/index.php/Nonsteroidal_anti-inflammatory_drug
Prediagnostic nonsteroidal anti-inflammatory drug use and lung cancer survival in the VITAL study<...Prediagnostic nonsteroidal anti-inflammatory drug use and lung cancer survival in the VITAL study<...
TY - JOUR. T1 - Prediagnostic nonsteroidal anti-inflammatory drug use and lung cancer survival in the VITAL study. AU - Brasky, Theodore M.. AU - Baik, Christina S.. AU - Slatore, Christopher G.. AU - Alvarado, Mariela. AU - White, Emily. PY - 2012/10. Y1 - 2012/10. N2 - Introduction: Inflammation is important for lung oncogenesis. Use of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to improve colorectal cancer survival. However, few studies have examined the association in lung cancer patients. Methods: The VITamins And Lifestyle (VITAL) cohort includes Washington State residents, aged 50 to 76 years, who completed a baseline questionnaire between 2000 and 2002. Participants responded on the frequency and duration of use of individual NSAIDs in the previous 10 years. Subjects of this study were 785 members of the cohort, who were identified with incident lung cancer from baseline through 2007 through linkage to a population-based cancer registry. Participants were followed for ...
https://ohsu.pure.elsevier.com/en/publications/prediagnostic-nonsteroidal-anti-inflammatory-drug-use-and-lung-ca-2
Synthesis, characterization, and biological activities of a Cu(II) complex with the non-steroidal antiinflammatory drug...Synthesis, characterization, and biological activities of a Cu(II) complex with the non-steroidal antiinflammatory drug...
Synthesis, characterization, and biological activities of a Cu(II) complex with the non-steroidal antiinflammatory drug flufenamic acid
https://figshare.com/articles/Synthesis_characterization_and_biological_activities_of_a_Cu_II_complex_with_the_non-steroidal_antiinflammatory_drug_flufenamic_acid/5472532
Protein binding of non-steroidal antiinflammatory drugs in rheumatoid arthritis<...Protein binding of non-steroidal antiinflammatory drugs in rheumatoid arthritis<...
TY - JOUR. T1 - Protein binding of non-steroidal antiinflammatory drugs in rheumatoid arthritis. AU - Wanwimolruk, Sompon. AU - Birkett, D. J.. AU - Brooks, P. M.. PY - 1981. Y1 - 1981. UR - http://www.scopus.com/inward/record.url?scp=0019802653&partnerID=8YFLogxK. M3 - Article. AN - SCOPUS:0019802653. VL - 11. SP - 719. JO - Australian and New Zealand Journal of Medicine. JF - Australian and New Zealand Journal of Medicine. SN - 0004-8291. IS - 6. ER - ...
https://researchnow.flinders.edu.au/en/publications/protein-binding-of-non-steroidal-antiinflammatory-drugs-in-rheuma
Non-steroidal Anti-inflammatory Drugs (NSAID) Market Division Including Snapshot That Provides Overall Information of Various...Non-steroidal Anti-inflammatory Drugs (NSAID) Market Division Including Snapshot That Provides Overall Information of Various...
In our aim to provide our erudite clients with the best research material with absolute in-depth information of the market, our new report on Global Non-steroidal Anti-inflammatory Drugs Market is confident in meeting their needs and expectations. The 2017 market research report on Global Non-steroidal Anti-inflammatory Drugs Market is an in-depth study and analysis of the market by our industry experts with unparalleled domain knowledge.. The report will shed light on many critical points and trends of the industry which are useful for our esteemed clients. The report covers a vast expanse of information including an overview, comprehensive analysis, definitions and classifications, applications, and expert opinions, among others. With the extent of information filled in the report, the presentation and style of the Global Non-steroidal Anti-inflammatory Drugs (NSAID) Market report is a noteworthy.. The Global Non-steroidal Anti-inflammatory Drugs (NSAID) Industry report provides key ...
http://www.globaltechnologyreport.com/story/117984/nonsteroidal-antiinflammatory-drugs-nsaid-market-division-including-snapshot-that-provides-overall-information-of-various-segments-and-subsegments.html
Pregabalin Confers No Added Benefit to a Non-steroid Anti-inflammatory Drug and Acetaminophen Regimen in Outpatient Breast...Pregabalin Confers No Added Benefit to a Non-steroid Anti-inflammatory Drug and Acetaminophen Regimen in Outpatient Breast...
Pregabalin Confers No Added Benefit to a Non-steroid Anti-inflammatory Drug and Acetaminophen Regimen in Outpatient Breast Cancer Surgery: A Randomized Controlled Trial Abstract.
https://www.omicsonline.org/peer-reviewed/pregabalin-confers-no-added-benefit-to-a-nonsteroid-antiinflammatory-drugand-acetaminophen-regimen-in-outpatient-breast-cancer-sur-24022.html
Emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology | British Journal of OphthalmologyEmerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology | British Journal of Ophthalmology
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
http://bjo.bmj.com/content/80/12/1117.1
The effect of nonsteroidal anti-inflammatory drugs on tissue healing | SpringerLinkThe effect of nonsteroidal anti-inflammatory drugs on tissue healing | SpringerLink
Purpose Non-selective (NSAIDs) and selective (COX-2) nonsteroidal anti-inflammatory drugs are commonly used for their analgesic and anti-inflammatory effects. Their role after orthopaedic surgery has...
https://link.springer.com/article/10.1007%2Fs00167-012-2095-2
Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats.<...Effect of nonsteroidal antiinflammatory drugs on fracture healing: a laboratory study in rats.<...
TY - JOUR. T1 - Effect of nonsteroidal antiinflammatory drugs on fracture healing. T2 - a laboratory study in rats.. AU - Altman, R. D.. AU - Latta, L. L.. AU - Keer, R.. AU - Renfree, K.. AU - Hornicek, F. J.. AU - Banovac, K.. PY - 1995. Y1 - 1995. N2 - We studied the effects of two nonsteroidal antiinflammatory drugs (NSAIDs) on fracture healing in rats: ibuprofen (30 mg/kg/day) and indomethacin (1 mg/kg/day). Femoral fractures were induced via a three-point bending technique. NSAIDs were administered orally for 4 or 12 weeks. Control animals received no medication. In each group a minimum of six animals were killed at the following intervals: 2, 4, 6, 8, 10, and 12 weeks postfracture. Fracture healing was determined by mechanical testing and histologic evaluation. The bending strength of each fractured femur was expressed as a percentage of the strength of the intact, contralateral femur. Histologic evaluation was performed on serial longitudinal sections stained with hematoxylin and eosin ...
https://mayoclinic.pure.elsevier.com/en/publications/effect-of-nonsteroidal-antiinflammatory-drugs-on-fracture-healing
Abstract: Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2...Abstract: Platelet function is inhibited by non-selective non-steroidal anti-inflammatory drugs but not by cyclo-oxygenase-2...
Interaction with platelet function by non-steroidal anti-inflammatory drugs (NSAIDs) is related to the inhibition of cyclo-oxygenase-1 (COX-1). In pat
http://www.prohealth.com/library/showarticle.cfm?libid=8374
Protection of Ischemia-Reperfusion Induced Cell Death by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Rat Retina |...Protection of Ischemia-Reperfusion Induced Cell Death by Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Rat Retina |...
Abstract: : Purpose: The degeneration of retinal neurons results in loss of vision. It has been known that Non Steroidal Anti-Inflammatory Drugs (NSAIDs) can protect the neuron from ischemic damage. The purpose of this study was to investigate the protective effect of NSAIDs in the rat retinal ischemia. Methods: Retinal ischemia in Sprague Dawley rats was induced by high intraocular pressure at 160 mmHg for 60 minutes after intra-ocular injection of saline, aspirin (5 to 20 mM), sulfasalazine (1 to 5 mM) or sulindac (0.01 to 0.1 mM). For morphological study, the retinas were embedded in epon 24 hours after ischemic injury. To determine neuronal survivorship in the retinal layers, the number of viable neurons was counted in 100µm X 25µm square and examined. Results: The intravitreal injections of aspirin, sulfasalazine or sulindac attenuated the ischemic neuronal degeneration in dose dependent. The protective effect of aspirin at concentration of 20 mM was observed to be 73%5.4 and 80%2.5 in ...
http://iovs.arvojournals.org/article.aspx?articleid=2418307
Coxibs and Other Nonsteroidal Anti-Inflammatory Drugs in Animal Models of Cancer Chemoprevention | Cancer Prevention ResearchCoxibs and Other Nonsteroidal Anti-Inflammatory Drugs in Animal Models of Cancer Chemoprevention | Cancer Prevention Research
NOTE: The calculations below are standard scaling factors that would be used for the FDA. They do not take into account specific pharmacokinetics of individual agents which can only properly be done after gavage dosing.. HEDs were calculated as follows, using 100 ppm (100 μg/g diet) as an example. Rats, which eat 15 g food daily, would consume 1.5 mg drug; for a 250 g rat, the daily weight-based dose would be 6 mg drug/kg body weight. Dividing by the rat-to-human scaling factor of 6, the HED is 1 mg/kg body weight; for an 80 kg human this is 80 mg. Mice, which eat 4 g food daily, would consume 0.4 mg drug; for a 25 g mouse, the daily weight-based dose would be 16 mg drug/kg body weight. Dividing by the mouse-to-human scaling factor of 12, the HED is 1.33 mg/kg body weight; for an 80 kg human this is 106 mg.. Abbreviation: HED, human equivalent dose.. ...
https://cancerpreventionresearch.aacrjournals.org/content/4/11/1728.figures-only
Limited inhibitory effects of non-steroidal antiinflammatory drugs on in vitro osteogenic differentiation in canine cells.Limited inhibitory effects of non-steroidal antiinflammatory drugs on in vitro osteogenic differentiation in canine cells.
Cyclooxygenase (COX)-2 participates essentially in bone healing, demonstrated by COX-2 knockout mice that showed delayed fracture repair. Considerable controversy still exists on inhibitory effects of COX-2 inhibitors on bone healing in clinical case
http://www.biomedsearch.com/nih/Limited-inhibitory-effects-non-steroidal/24059095.html
Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers - Tabular View -...Natural History of Non-steroidal Anti-inflammatory Drug and Non-Helicobacter Pylori in Bleeding Peptic Ulcers - Tabular View -...
Non-steroidal Anti-inflammatory Drugs (NSAID), Non-Helicobacter pylori (HP) bleeding peptic ulcers are relatively common in the West (11%-44%). It is uncommon in Hong Kong (4%). Significant number of these patients with non-NSAID, non-Hp bleeding ulcers had co-morbid illness and many had life-threatening conditions. Our recent study showed that there is an increasing incidence of non-steroidal anti-inflammatory drugs (NSAID), non-Helicobacter pylori (Hp) bleeding peptic ulcers. There is no datum on the natural course of these patients and this is our aim to have this observational study ...
https://clinicaltrials.gov/ct2/show/record/NCT00153712
Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs<...Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs<...
TY - JOUR. T1 - Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs. AU - Puhl, Ana C.. AU - Milton, Flora A.. AU - Cvoro, Aleksandra. AU - Sieglaff, Douglas H.. AU - Campos, Jéssica C.L.. AU - Bernardes, Amanda. AU - Filgueira, Carly S.. AU - Lindemann, Jan Lammel. AU - Deng, Tuo. AU - Neves, Francisco A R. AU - Polikarpov, Igor. AU - Webb, Paul. PY - 2015. Y1 - 2015. N2 - Non-steroidal anti-inflammatory drugs (NSAIDs) display anti-inflammatory, antipyretic and analgesic properties by inhibiting cyclooxygenases and blocking prostaglandin production. Previous studies, however, suggested that some NSAIDs also modulate peroxisome proliferator activated receptors (PPARs), raising the possibility that such off target effects contribute to the spectrum of clinically relevant NSAID actions. In this study, we set out to understand how peroxisome proliferator activated receptor-γ (PPARγ/PPARG) interacts with NSAIDs using X-ray ...
https://scholars.houstonmethodist.org/en/publications/mechanisms-of-peroxisome-proliferator-activated-receptor-%CE%B3-regula
Epidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study | BMC Public Health | Full TextEpidemiology of non-steroidal anti-inflammatory drugs consumption in Spain. The MCC-Spain study | BMC Public Health | Full Text
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used despite their risk of gastrointestinal bleeding or cardiovascular events. We report the profile of people taking NSAIDs in Spain, and we include demographic factors, health-related behaviours and cardiovascular disease history. Four thousand sixtyparticipants were selected using a pseudorandom number list from Family Practice lists in 12 Spanish provinces. They completed a face-to-face computerized interview on their NSAID consumption, demographic characteristics, body mass index, alcohol and tobacco consumption and medical history. In addition, participants completed a self-administered food-frequency and alcohol consumption questionnaire. Factors associated with ever and current NSAID consumption were identified by logistic regression. Women consumed more non-aspirin NSAIDs (38.8% [36.7-41.0]) than men (22.3 [20.5-24.2]), but men consumed more aspirin (11.7% [10.3-13.2]) than women (5.2% [4.3-6.3]). Consumption of non-aspirin NSAIDs
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-018-6019-z
Advanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review | Bentham ScienceAdvanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review | Bentham Science
Title:Advanced Drug Delivery Systems for Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs: A Review. VOLUME: 15 ISSUE: 8. Author(s):Lalit Kumar, Shivani Verma, Mehakjot Singh, Tammana Chalotra and Puneet Utreja*. Affiliation:Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, I. K. Gujral Punjab Technical University, Jalandhar-Punjab 144601, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021, Faculty of Pharmaceutical Sciences, Department of Pharmaceutics, PCTE Group of Institutes, Ludhiana, Punjab 142021. Keywords:Dendrimer, liposomes, nanocarrier, nanofibers, transdermal, niosomes, ethosomes.. Abstract:Background: Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like ...
http://www.eurekaselect.com/162817/article
Non-Steroidal Anti-Inflammatory Drugs as Anti-Amyloidogenic Compounds | Bentham ScienceNon-Steroidal Anti-Inflammatory Drugs as Anti-Amyloidogenic Compounds | Bentham Science
Title: Non-Steroidal Anti-Inflammatory Drugs as Anti-Amyloidogenic Compounds. VOLUME: 14 ISSUE: 30. Author(s):Mie Hirohata, Kenjiro Ono and Masahito Yamada. Affiliation:Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan.. Keywords:Alzheimers disease, amyloid β-peptide (Aβ), amyloidosis, α-synuclein fibrils, central nervous system, neuroinflammation, non-steroidal anti-inflammatory drugs (NSAIDs), protein-misfolding disorders. Abstract: Amyloidosis is a clinical disorder caused by deposition of proteins that abnormally self-assemble into insoluble fibrils and impair organ function. More than 20 unrelated precursor proteins lose their native structure and misfold, leading to the formation of amyloid fibrils. The latter share cross-β core structure in vivo and in vitro and gain abnormal functions. Local amyloid deposition occurs in the central nervous system in Alzheimers disease (AD) and cerebral amyloid ...
https://www.eurekaselect.com/67977/article/non-steroidal-anti-inflammatory-drugs-anti-amyloidogenic-compounds?tracking-code=4
Role of a nonsteroidal anti-inflammatory agent, ibuprofen, in coronary revascularization after acute myocardial infarction |...Role of a nonsteroidal anti-inflammatory agent, ibuprofen, in coronary revascularization after acute myocardial infarction |...
The efficacy of using a nonsteroidal anti-inflammatory agent such as ibuprofen for the salvage of ischemic and reperfused myocardium was investigated by examining its ability to improve global and...
https://link.springer.com/article/10.1007/BF01907014
Anti Viral - Melora (Brand name: mobic) Buy Cheap online Price: 0.28 - Anti Viral, Mobic is a non steroidal anti...Anti Viral - Melora (Brand name: mobic) Buy Cheap online Price: 0.28 - Anti Viral, Mobic is a non steroidal anti...
Buy Cheap on line Anti Viral - Melora (Brand name: mobic) - Mobic is a non steroidal anti-inflammatory drug that is used in the treatment of arthritis.
https://sex-ru.org/categories/Anti-Viral/Mobic/Melora
Cyclooxygenase 2 Polymorphism (Val511Ala), Nonsteroidal Anti-inflammatory Drug Use and Breast Cancer in African American Women ...Cyclooxygenase 2 Polymorphism (Val511Ala), Nonsteroidal Anti-inflammatory Drug Use and Breast Cancer in African American Women ...
Although a previous report from a study of colon cancer suggested that the Val511Ala polymorphism had an effect on colon cancer risk comparable in magnitude (OR ≈ 0.6) to the protective effect that has been reported consistently for aspirin and other NSAIDs, our results showed no association between this polymorphism and breast cancer. We also found no evidence suggesting that the Val511Ala polymorphism modified the relationship between NSAID use and breast cancer; ORs ,1 were observed for NSAID users regardless of genotype. This suggests that the role of COX2 may be different in breast cancer than colon cancer, a notion that is supported by data on NSAID use and breast cancer. Although most epidemiologic studies (3, 7-10) have reported inverse associations between NSAID use and breast cancer, the body of literature is less consistent than it is for colon cancer and the magnitude of the associations with aspirin/NSAID use have tended to be weaker than those reported for colon cancer.. The ...
https://cebp.aacrjournals.org/content/14/12/3013?ijkey=dcd51da5d503fa47bfcfdaba14712c714d549715&keytype2=tf_ipsecsha
Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast...Regular and low-dose aspirin, other non-steroidal anti-inflammatory medications and prospective risk of HER2-defined breast...
In 1995 − 1996, participants in the California Teachers Study completed a baseline questionnaire on family history of cancer and other conditions, use of NSAIDs, menstrual and reproductive history, self-reported weight and height, living environment, diet, alcohol use, and physical activity. In 2005-2006, 57,164 participants provided some updated information, including use of NSAIDs and 1457 of these participants developed invasive breast cancer before January 2013. Multivariable Cox proportional hazards regression models provided hazard rate ratios (HRR) for the association between NSAID use and risk of invasive breast cancer as well as hormone receptor- and HER2-defined subtypes.. ...
http://breastcancercare.org/research-clinical-trials/research/regular-and-low-dose-aspirin-other-non-steroidal-anti-inflammatory-medications-and-prospective-risk-of-her2-defined-breast-cancer-the-california-teachers-study/
Treatment and chemoprevention of NSAID-associated gastrointestinal com | TCRMTreatment and chemoprevention of NSAID-associated gastrointestinal com | TCRM
Treatment and chemoprevention of NSAID-associated gastrointestinal complications Edward J Frech1,2, Mae F Go1,21GI Section, George E Wahlen Department of Veterans Affairs Medical Center; 2Division of Gastroenterology, University of Utah School of Medicine, Salt Lake City, Utah, USAAbstract: The use of non-steroidal anti-inflammatory drugs has become ubiquitous worldwide and remains a common source of gastrointestinal morbidity. Antisecretory medications, particularly proton pump inhibitors, are effective in the treatment and prevention of NSAID-related gastrointestinal complications, including peptic ulcer disease and non-ulcer dyspepsia. A careful assessment of patients risk factors for developing NSAID-related gastrointestinal complications should be undertaken prior to initiation of any NSAIDs. Patients who are considered at risk for developing gastrointestinal complications should receive concurrent antisecretory medical therapy to minimize the risk for GI complications.Keywords: NSAIDs, peptic
https://www.dovepress.com/treatment-and-chemoprevention-of-nsaid-associated-gastrointestinal-com-peer-reviewed-article-TCRM
Torts Today: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or...Torts Today: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or...
The U.S. Food and Drug Administration (FDA) is strengthening an existing label warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) increase the chance of a heart attack or stroke. Based on our comprehensive review of new safety information, we are requiring updates to the drug labels of all prescription NSAIDs. As is the case with current prescription NSAID labels, the Drug Facts labels of over-the-counter (OTC) non-aspirin NSAIDs already contain information on heart attack and stroke risk. We will also request updates to the OTC non-aspirin NSAID Drug Facts labels ...
http://tortstoday.blogspot.com/2015/07/fda-strengthens-warning-that-non.html
NSAID Archives - Marie Spano, MS, RD, CSCS, CSSDNSAID Archives - Marie Spano, MS, RD, CSCS, CSSD
NSAIDs (non steroidal anti-inflammatory drugs) like ibuprofen (Advil) and indomethacin may speed up the breakdown of cartilage in osteoarthritic joints. They might also inhibit tissue repair. But, not all studies show NSAIDs damage cartilage. It may depend on the specific NSAID. The best study Ive seen to date (and also published in a very reputable journal) found older adults (a group that commonly has osteoarthritis) who used NSAIDs including diclofenac, ibuprofen, naproxen, ketoprofen and piroxican for an extended period of time had higher risk of cartilage defects and nonsignificant loss of cartilage compared to nonusers.. Osteoarthritis is very common (athletes, older adults, those who are overweight, those who have been very active their whole life) and is wear and tear arthritis; symptoms include joint pain and stiffness.. If you have mild osteoarthritis look for other solutions including curcumin, glucosamine and chondroitin sulfate, and boswella serrata AKBA.. ...
http://www.mariespano.com/tag/nsaid/
non-steroidal anti-inflammatory drugnon-steroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs-but also referred to as nonsteroidal anti-inflammatory agents/analgesics (NSAIAs)
https://homecuresforgout.org/non-steroidal-anti-inflammatory-drug/?wiki-maping=Suxibuzone
non-steroidal anti-inflammatory drugnon-steroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drugs, usually abbreviated to NSAIDs-but also referred to as nonsteroidal anti-inflammatory agents/analgesics (NSAIAs)
https://homecuresforgout.org/non-steroidal-anti-inflammatory-drug/?wiki-maping=Premature_birth
piroxicam Archives - Marie Spano, MS, RD, CSCS, CSSDpiroxicam Archives - Marie Spano, MS, RD, CSCS, CSSD
NSAIDs (non steroidal anti-inflammatory drugs) like ibuprofen (Advil) and indomethacin may speed up the breakdown of cartilage in osteoarthritic joints. They might also inhibit tissue repair. But, not all studies show NSAIDs damage cartilage. It may depend on the specific NSAID. The best study Ive seen to date (and also published in a very reputable journal) found older adults (a group that commonly has osteoarthritis) who used NSAIDs including diclofenac, ibuprofen, naproxen, ketoprofen and piroxican for an extended period of time had higher risk of cartilage defects and nonsignificant loss of cartilage compared to nonusers.. Osteoarthritis is very common (athletes, older adults, those who are overweight, those who have been very active their whole life) and is wear and tear arthritis; symptoms include joint pain and stiffness.. If you have mild osteoarthritis look for other solutions including curcumin, glucosamine and chondroitin sulfate, and boswella serrata AKBA.. ...
http://www.mariespano.com/tag/piroxicam/
Advances in Equine Medicine - Horse IllustratedAdvances in Equine Medicine - Horse Illustrated
Fortunately, therapeutic options for numerous conditions are available for horses, and new treatments continue to reach the market regularly. One noteworthy medication introduced over the past decade is diclofenac (trade name Surpass). A topical non-steroidal anti-inflammatory drug (NSAID) approved in 2004, diclofenac now gives veterinarians the option to localize treatment of osteoarthritis to a specific joint instead of administering broad, systematic treatment.. Another recent addition to the equine NSAID arsenal is firocoxib (trade name Equioxx). A non-steroidal anti-inflammatory agent like phenylbutazone (bute) or flunixin meglumine (Banamine), this oral medication came to the U.S. market in 2007 for use in treatment of pain associated with osteoarthritis. Noted for being less harmful to the gastrointestinal tract, firocoxib has given veterinarians another option when treating horses with OA pain.. Gastric ulcers have been in the spotlight for the past few decades as a potentially insidious ...
https://www.horseillustrated.com/horse-health-advances-in-equine-medicine
How to reduce GI bleeding and ulcers in patients taking NSAIDsHow to reduce GI bleeding and ulcers in patients taking NSAIDs
Youll see a lot of attention focused on how to reduce GI bleeding and ulcers in patients taking NSAIDs. ... Learn more with Prescribers Letter.
https://prescriber.therapeuticresearch.com/Content/Articles/PRL/1998/Feb/How-to-reduce-GI-bleeding-and-ulcers-in-patients-taking-NSAIDs
Dosage effects of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID)...Dosage effects of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID)...
BACKGROUND: A histamine-2 receptor antagonist (H2RA) is one of the common gastroprotective co-therapies used with non-steroidal anti-inflammatory drugs (NSAIDs) for the prevention or treatment of peptic ulcers (PUs). To date, no study has directly compared the prophylactic effectiveness between high-dose and low-dose H2RA. OBJECTIVE: Our objective was to compare the effectiveness of high-dose versus low-dose H2RAs in the primary prophylaxis of PUs among short-term NSAID users. METHODS: A retrospective cohort study was conducted using the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong. Patients aged 18 years or above who received a single prescription of oral NSAID with oral H2RA were identified within the study period (1 January 2009-31 December 2012). Patients with a history of or risk factors for PU in the corresponding 2 years prior to the index date (of the first NSAID prescription) were excluded. Log binomial regression analysis was used to calculate the relative risk of PU among
https://www.ndorms.ox.ac.uk/publications/942979/
Dosage effects of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID)...Dosage effects of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID)...
BACKGROUND: A histamine-2 receptor antagonist (H2RA) is one of the common gastroprotective co-therapies used with non-steroidal anti-inflammatory drugs (NSAIDs) for the prevention or treatment of peptic ulcers (PUs). To date, no study has directly compared the prophylactic effectiveness between high-dose and low-dose H2RA. OBJECTIVE: Our objective was to compare the effectiveness of high-dose versus low-dose H2RAs in the primary prophylaxis of PUs among short-term NSAID users. METHODS: A retrospective cohort study was conducted using the Clinical Data Analysis and Reporting System (CDARS) in Hong Kong. Patients aged 18 years or above who received a single prescription of oral NSAID with oral H2RA were identified within the study period (1 January 2009-31 December 2012). Patients with a history of or risk factors for PU in the corresponding 2 years prior to the index date (of the first NSAID prescription) were excluded. Log binomial regression analysis was used to calculate the relative risk of PU among
https://www.ndorms.ox.ac.uk/publications/942979
Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug...Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug...
OBJECTIVE. Enteric bacteria play a significant role in the pathogenesis of non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal damage. However, the association between small intestinal bacterial overgrowth (SIBO) and NSAID-induced small intestinal damage remains unclear. The aim of …
https://pubmed.ncbi.nlm.nih.gov/24417613/
Jens RA Journey: February 2012Jens RA Journey: February 2012
In ancient times, it was believed throughout the world that the root cause of ailments was the bodys buildup of toxins. This accumulation of toxins and incomplete processes of food in the gastrointestinal tract can be thought to be a source of decreased immunity. This concept of toxicity, food allergens and environmental toxic sources lead to a creation of immune complications, which in turn creates the many symptoms in patients suffering from arthritis. Natural therapy, including taking supplements and herbs, and taking care of your intestinal tract, can increase your chances of becoming symptom free. Its important to understand that taking non-steroidal anti-inflammatory agents(NSAIDS) make the lining of your intestinal tract weaker, thus, giving you leaky gut which leads to worsening of disease. The intestinal tracts position and processes are integral in keeping your body healthy because it is the bodys first line of defense. Keeping awareness of what can induce GI inflammation will be ...
http://jensrajourney.blogspot.com/2012/02/
Jens RA Journey: 2012Jens RA Journey: 2012
In ancient times, it was believed throughout the world that the root cause of ailments was the bodys buildup of toxins. This accumulation of toxins and incomplete processes of food in the gastrointestinal tract can be thought to be a source of decreased immunity. This concept of toxicity, food allergens and environmental toxic sources lead to a creation of immune complications, which in turn creates the many symptoms in patients suffering from arthritis. Natural therapy, including taking supplements and herbs, and taking care of your intestinal tract, can increase your chances of becoming symptom free. Its important to understand that taking non-steroidal anti-inflammatory agents(NSAIDS) make the lining of your intestinal tract weaker, thus, giving you leaky gut which leads to worsening of disease. The intestinal tracts position and processes are integral in keeping your body healthy because it is the bodys first line of defense. Keeping awareness of what can induce GI inflammation will be ...
http://jensrajourney.blogspot.com/2012/
Plus itPlus it
OBJECTIVE: To evaluate the prophylactic effect of ranitidine 150 mg twice daily in patients requiring one of the following non-steroidal anti-inflammatory drugs: naproxen, piroxicam, diclofenac, and indomethacin. In addition, risk factors were studied in order to help in targeting of such treatment to specific groups of patients. DESIGN: Double blind, placebo controlled, randomised, parallel group with endoscopic assessments at 0, 4, and 8 weeks. SETTING: Multicentre outpatient study at secondary referral centres in five European countries. PATIENTS--297 patients with rheumatoid arthritis or osteoarthritis over the age of 18 without lesions in the stomach and duodenum at baseline endoscopy (after one week without taking non-steroidal anti-inflammatory drugs). Those taking other antirheumatic agents, concomitant ulcerogenic drugs, or treatment for peptic ulcers within the previous 30 days were excluded. Age, sex, arthritic disease, and type of non-steroidal anti-inflammatory drug used were ...
http://www.bmj.com/content/297/6655/1017
Iraqi Academic Scientific Journals - IASJIraqi Academic Scientific Journals - IASJ
ABSTRACT:BACKGROUND:Non Steroidal Anti-Inflammatory drugs (NSAIDs) are used to treat musculoskeletal disorders, inflammation and to control pain. Virtually all (NSAIDs) are capable of producing liver injury ranging from mild reversible elevation of liver enzymes to severe hepatic failure.OBJECTIVE:To estimate the hepatic risk associated with the use of some NSAIDs. SUBJECT AND METHOD:80 osteoarthritic patients were on diclofenac acid (voltarin) tablets 75 mg, 60 of them were female and 20 were male, laboratory estimation of serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), serum alkaline phosphatase activity and total serum bilirubin (TSB) were done. For comparison age and sex matched 96 apparently healthy persons serve as controls.RESULTS:27 (33.75 %) of the diclofenac treated patients had some impairment of liver function tests, 66.6 % of the liver injury found in patients aged more than 50 years and 88.8 % had occurred in females. hepatocelluar injury characterize ...
https://www.iasj.net/iasj/article/49021
Nonsteroidal anti-inflammatory drugs in Alzheimers disease | NeurologyNonsteroidal anti-inflammatory drugs in Alzheimers disease | Neurology
Finally, because patients may have been taking aspirin in low doses for cardiac or stroke prophylaxis rather than the larger doses used for anti- inflammatory purposes, and because other studies involving anti-inflammatories did not include aspirin as an NSAID, we conducted additional analyses excluding patients taking aspirin or aspirin-containing medications. This reduced the NSAID group to 21 patients; the non-NSAID group remained unchanged at 177 patients. After covarying for years ill, analyses revealed that the NSAID group performed better than did the non-NSAID group on the MMSE (NSAID residualized mean = 17.32, non-NSAID mean = 14.16, p = 0.017) and the Boston Naming Test (NSAID residualized mean = 17.63, non-NSAID mean = 13.91, p = 0.05).. Discussion. The results of this study support a protective role for anti-inflammatory medications in the cognitive impairment of patients clinically diagnosed with AD. Even after correcting for disease duration, patients taking NSAIDs had higher ...
https://n.neurology.org/content/45/1/51?ijkey=399e1fbfd58c92b902ab68354bee2e8a2e993bdb&keytype2=tf_ipsecsha
Zantac Tablets 150mg | Medicines.ieZantac Tablets 150mg | Medicines.ie
4.1 Therapeutic indications. In the treatment of duodenal ulcer and benign gastric ulcer including that associated with non-steroidal anti-inflammatory agents. Prevention of non-steroidal anti-inflammatory drug (including aspirin) associated duodenal ulcers, especially in patients with a history of peptic ulcer disease. Zantac Tablets are also indicated for treatment of post-operative ulcer, reflux oesophagitis, Zollinger-Ellison syndrome and other conditions where reduction of gastric acid secretion is likely to be beneficial.. Children (3 to 18 years). · Short term treatment of peptic ulcer · Treatment of gastro-oesophageal reflux, including reflux oesophagitis and symptomatic relief of gastro-oesophageal reflux disease. 4.2 Posology and Method of Administration. Adults (including the elderly) / Adolescents (12 years and over) The usual initial dosage is 150mg bd or 300mg nocte. This may be increased to ranitidine 300mg twice daily without an increased incidence of unwanted effects. ...
https://www.medicines.ie/medicines/zantac-tablets-150mg-34289/company-info/page-1/per-page-25
DJD | Cherrydown VetsDJD | Cherrydown Vets
Drugs a) NSAIDs. The cornerstone of DJD treatment is Non Steroidal Anti-Inflammatory Drugs (NSAIDS). They have both anti-inflammatory and analgesic (pain killing) effects. All NSAIDs have the potential to cause side effects in some animals. These include: - Gastro-intestinal side effects such as vomiting and diarrhoea can occur. More seriously ulceration of the gastro-intestinal tract can occur. This causes vomit with blood in it, black tar like faeces (malaena), and can be fatal if left untreated. - Exacerbation of degradation of the articular cartilage by increasing cartilage breakdown or by reducing glycosaminoglycan synthesis. Thus, the drug that is most commonly used for treating DJD has been shown to speed up the progress and deterioration of the disease. - Kidney toxicity. Nsaids can be damaging to kidneys especially where there is existing kidney disease or when there is risk of low blood pressure such as dehydration, heart disease, general anaesthetic - Affect blood clotting - Liver ...
https://www.cherrydownvets.co.uk/news/tag/djd/
Association between nonsteroidal anti-inflammatory drug use and major adverse cardiovascular events in patients with end-stage...Association between nonsteroidal anti-inflammatory drug use and major adverse cardiovascular events in patients with end-stage...
TY - JOUR. T1 - Association between nonsteroidal anti-inflammatory drug use and major adverse cardiovascular events in patients with end-stage renal disease. T2 - a population-based cohort study. AU - Liao, Yu Chen. AU - Chang, Chuen Chau. AU - Chen, Ta Liang. AU - Liu, Chih Chung. AU - Chen, Hsi Hsien. AU - Lee, Yuan Wen. N1 - Funding Information: This study was supported by a Grant from the Taiwan Ministry of Health and Welfare (CCMP102-RD-015). This study was based in part on data from the Taiwan National Health Insurance Research Database provided by the National Health Insurance Administration, Ministry of Health and Welfare and managed by National Health Research Institutes. The interpretations and conclusions contained herein do not represent those of the National Health Insurance Administration, Ministry of Health and Welfare or of the National Health Research Institutes. This manuscript was edited by Wallace Academic Editing. Publisher Copyright: © 2020, Italian Society of Nephrology. ...
https://tmu.pure.elsevier.com/zh/publications/association-between-nonsteroidal-anti-inflammatory-drug-use-and-m
Do non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes? | AVESİSDo non-steroidal anti-inflammatory drugs induce sister chromatid exchanges in T lymphocytes? | AVESİS
The genetic toxicity of non-steroidal anti-inflammatory drugs was investigated using the sister chromatid exchange technique in cultured human lymphocytes. A total of 48 patients were treated with non-steroidal anti-inflammatory drugs (ibuprofen, ketoprofen, naproxen, indomethacin, diclofenac or acetylsalicylic acid) for 2 weeks, The average numbers of sister chromatid exchanges in cultured lymphocytes from the patients, before and after treatment with these drugs, did not differ significantly (P > 0.05), These results indicate that treatment with non-steroidal anti-inflammatory drugs for 2 weeks does not induce sister chromatid exchanges in T lymphocytes. ...
https://avesis.erciyes.edu.tr/yayin/55161f73-3b8c-4a4b-b2b0-66888b6d0dfc/do-non-steroidal-anti-inflammatory-drugs-induce-sister-chromatid-exchanges-in-t-lymphocytes
소장자료상세 - 연세대학교 의학도서관소장자료상세 - 연세대학교 의학도서관
General Considerations on Anatomy and Pathogenesis of Scleral Inflammation -- Classification and Clinical Presentations -- Associated Systemic Diseases -- Infectious Scleritis -- Diagnostic Approach to Scleritis -- Complications and their Management -- Management with Non-Steroidal Anti-Inflammatory Agents -- Management with Steroids: Local and Systemic -- Management with Immunosuppressive Therapy and Biologics ...
https://ymlib.yonsei.ac.kr/en/catalog/search/book-detail/?rurl=%2Fen%2Fcatalog%2Fsearch%2F%3Fquery%3DOphthalmology%26si%3DTOTAL%26st%3DFRNT%26bk_3%3Djttj2017jttj%26sortkey%3Dpublisher%26sortorder%3DASC%26&cid=CAT000000392000
Intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs: Role of bile salts<...Intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs: Role of bile salts<...
TY - JOUR. T1 - Intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs. T2 - Role of bile salts. AU - Petruzzelli, Michele. AU - Vacca, Michele. AU - Moschetta, Antonio. AU - Cinzia Sasso, Rosa. AU - Palasciano, Giuseppe. AU - van Erpecum, Karel J.. AU - Portincasa, Piero. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2007/5. Y1 - 2007/5. N2 - The strong analgesic, anti-inflammatory effects of non-steroidal anti-inflammatory drugs (NSAIDs) are hampered by high occurrence of gastrointestinal side effects. Therapeutic actions of NSAIDs result from cyclooxygenase (COX) enzymes inhibition with reduced synthesis of prostaglandins, major modulators of inflammation. Since prostaglandins also regulate key events in gut homeostasis -mucosal secretion, blood flow, epithelial regeneration - COX inhibition has been accepted as the reason for NSAID gastrointestinal toxicity. Several findings challenge this theory: first, intestinal damage by NSAIDs occurs also in ...
https://utsouthwestern.pure.elsevier.com/en/publications/intestinal-mucosal-damage-caused-by-non-steroidal-anti-inflammato
Risks of gastrointestinal ulcers linked to aspirin use might outweigh its benefits for the heartRisks of gastrointestinal ulcers linked to aspirin use might outweigh its benefits for the heart
Sonia Hernández-Díaz and Luis García Rodríguez analysed two anonymous databases of patient information, the General Practice Research Database in the UK and the Base de Datos para la Investigación Farmacoepidemiológica en Atención Primaria in Spain, to characterise patients taking low-dose aspirin as a preventive measure against heart attack, in terms of major gastrointestinal risk factors. Risk factors for upper gastrointestinal tract complications include advanced age, male sex, prior ulcer history and use of other non-steroidal anti-inflammatory drugs (NSAIDs). The researchers then estimated the excess gastrointestinal risk caused by aspirin use in patients with and without these risk factors. Hernández-Díaz and García Rodríguez find that 88% of aspirin users are over 60 and that 52-54% of them are male. From 3.8% to 5.9% of them have a history of gastrointestinal ulcer. Across all risk groups, aspirin use is responsible for an extra 5-6 cases of upper gastrointestinal tract ...
http://www.innovations-report.com/html/reports/medicine-health/report-70858.html
Regular Aspirin Use Linked to Age-Related Macular DegenerationRegular Aspirin Use Linked to Age-Related Macular Degeneration
A new study found that regular aspirin use is significantly associated with an increased incidence of neovascular AMD, a leading cause of blindness in older people.. Researchers at the Center for Vision Research from the Westmead Millennium Institute for Medical Research (WMI), a close affiliate of the University of Sydney, have found that regular aspirin consumption is associated with an increased risk of neovascular age-related macular degeneration (AMD) - a leading cause of blindness in older people.. The research shows that the risk appears to be independent of a history of smoking, which is also a known preventable risk factor for AMD.. Aspirin is one of the most widely used medications in the world with more than 100 billion tablets consumed each year. Aspirin is commonly used in the prevention of cardiovascular disease, such as myocardial infarction (heart attack) and ischemic stroke.. While a five-year European study published last year suggested that regular aspirin use (defined as once ...
https://scitechdaily.com/regular-aspirin-use-linked-to-age-related-macular-degeneration/
Non steroidal | definition of Non steroidal by Medical dictionaryNon steroidal | definition of Non steroidal by Medical dictionary
Looking for online definition of Non steroidal in the Medical Dictionary? Non steroidal explanation free. What is Non steroidal? Meaning of Non steroidal medical term. What does Non steroidal mean?
https://medical-dictionary.thefreedictionary.com/Non+steroidal
Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-steroidal Anti-inflammatory Drugs - Full Text...Total Antioxidant Effects of Esomeprazole in Dyspeptic Patients Receiving Non-steroidal Anti-inflammatory Drugs - Full Text...
An extensive meta-analysis has confirmed that dyspeptic symptoms are common in individuals using non-steroidal anti-inflammatory drugs (NSAIDs) (1). Both esomeprazole 20 mg daily and esomeprazole 40 mg daily have been shown to be more effective than placebo for the control of upper gastrointestinal symptoms in patients receiving NSAIDs (2).. The mechanisms by which H, K-ATPase inhibitors protect against NSAID gastropathy remain unclear, although it is known that their use is more clinically effective than the use of the H2-receptor antagonist, ranitidine (3).. The biochemical basis for NSAID gastropathy is not fully understood (6). One potential mechanism for the development of gastric damage in individuals receiving NSAIDs is oxidative stress related to depletion of gastric antioxidants. A recent endoscopic study in patients supports the hypothesis that NSAID use associated with gastric bleeding decreases gastric mucosal glutathione levels (7), a major cellular micronutrient antioxidant ...
https://clinicaltrials.gov/show/NCT00443963
Health News Report: NIH study finds regular aspirin use may reduce ovarian cancer riskHealth News Report: NIH study finds regular aspirin use may reduce ovarian cancer risk
Among study participants who reported whether or not they used aspirin regularly: 18 percent used aspirin, 24 percent used non-aspirin NSAIDs, and 16 percent used acetaminophen. The researchers determined that participants who reported daily aspirin use had a 20 percent lower risk of ovarian cancer than those who used aspirin less than once per week. For non-aspirin NSAIDs, which include a wide variety of drugs, the picture was less clear: the scientists observed a 10 percent lower ovarian cancer risk among women who used NSAIDs at least once per week compared with those who used NSAIDs less frequently. However, this finding did not fall in a range that was significant statistically. In contrast to the findings for aspirin and NSAIDs, use of acetaminophen, which is not an anti-inflammatory agent, was not associated with reduced ovarian cancer risk ...
http://healthnewsreport.blogspot.com/2014/02/nih-study-finds-regular-aspirin-use-may.html
Which medications in the drug class Nonsteroidal anti-inflammatory drugs are used in the treatment of Carpal Tunnel Syndrome?Which medications in the drug class Nonsteroidal anti-inflammatory drugs are used in the treatment of Carpal Tunnel Syndrome?
Nonsteroidal anti-inflammatory drugsNSAIDs provide pain relief and reduction of inflammation. Reducing inflammation in the structures passing through the carpal tunnel decreases pressure and provides ... more
https://www.medscape.com/answers/327330-86568/which-medications-in-the-drug-class-nonsteroidal-anti-inflammatory-drugs-are-used-in-the-treatment-of-carpal-tunnel-syndrome
Utilization of gastroprotective strategies for nonsteroidal anti-infla | TCRMUtilization of gastroprotective strategies for nonsteroidal anti-infla | TCRM
Utilization of gastroprotective strategies for nonsteroidal anti-inflammatory drug-induced gastrointestinal events in a major teaching hospital Hooi Leng Lee,1 Siew Siang Chua,1 Sanjiv Mahadeva2 1Department of Pharmacy, 2Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia Background and purpose: Clinical guidelines recommend the prescribing of gastroprotective strategies in nonsteroidal anti-inflammatory drug (NSAID) users with risk factors for gastrointestinal (GI) ulcer or ulcer complications. However, these guidelines are not often translated into clinical practice. Therefore, the aim of this study was to investigate the utilization of gastroprotective strategies for NSAID-induced upper GI events in at-risk users in a major teaching hospital. Patients and methods: A cross-sectional, observational, pharmacy-based study was conducted in a major Asian institution with both primary and secondary health care services. This study involved the screening of
https://www.dovepress.com/utilization-of-gastroprotective-strategies-for-nonsteroidal-anti-infla-peer-reviewed-article-TCRM
Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study | RTINon-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study | RTI
OBJECTIVES: To investigate the cardiovascular safety of non-steroidal anti-inflammatory drugs (NSAIDs) and estimate the risk of hospital admission for heart failure with use of individual NSAIDs. DESIGN: Nested case-control study. SETTING: Five population based healthcare databases from four European countries (the Netherlands, Italy, Germany, and the United Kingdom). PARTICIPANTS:
https://www.rti.org/publication/non-steroidal-anti-inflammatory-drugs-and-risk-heart-failure-four-european-countries
UK Study Tests Form of Ibuprofen as Coronavirus Treatment - Laopdr News GazetteUK Study Tests Form of Ibuprofen as Coronavirus Treatment - Laopdr News Gazette
A form of ibuprofen called flarin is being studied in Britain to see if it is effective for treating COVID-19 respiratory symptoms caused by the coronavirus.. Also called lipid ibuprofen, flarin has anti-inflammatory effects and is designed to shield the stomach from irritation when taken.. The study, LIBERATE Trial in COVID-19, aims to test flarin on 230 people who have been hospitalized due to COVID-19 and have acute respiratory failure. Only patients who are 18 or older are eligible.. COVID-19 patients who have shown hypersensitivity to other non-steroidal anti-inflammatory drugs (NSAIDS) do not qualify for the study.. Ibuprofen received attention in March, when French Health Minister Olivier Veran tweeted that NSAIDS, which include ibuprofen, could aggravate COVID-19 symptoms.. Since then, the World Health Organization, European Medicines Agency and other groups said there was not enough evidence to prove ibuprofen would worsen COVID-19 symptoms.. The sponsor of the LIBERATE study is Kings ...
https://www.laopdrnewsgazette.com/uk-study-tests-form-of-ibuprofen-as-coronavirus-treatment/
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http://hleb.kitunebi.com/image/online/naproxen.html
Ibuprofen Vs. Paracetamol: Which Is Better? | Get Rid Of GoutIbuprofen Vs. Paracetamol: Which Is Better? | Get Rid Of Gout
The only similarity that the two has is that they both have side effects and they both have the capacity of relieving pain. Take not, they relieve only pain. The similarity ends in here. On the other hand, the difference between the two is a lot.. Ibuprofen may treat the inflammation and pain even though it needs a larger dosage to treat the former one. The paracetamol, however, can treat the pain and nut the inflammation. it has the capacity to do so but there is a need for larger dosage, which may cause harm.. Both ibuprofen and paracetamol have their own share of side effects. The ibuprofen, just like any other Non-Steroidal Anti-inflammatory Drugs may impose ulcer, cardiovascular illnesses, and a number of allergic reactions. On the other hand, paracetamol may cause the liver to get damage and even asthma.. If you observe, paracetamol is less effective than the ibuprofen. However, it has lesser side effects. On the other hand, the long-term dependence or the overdose on paracetamol may be ...
https://getridgout.com/ibuprofen-vs-paracetamol-which-is-better/
Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis - InpharmD™Secukinumab Inhibition of Interleukin-17A in Patients with Psoriatic Arthritis - InpharmD™
Tony Sampson, Mercer University College of Pharmacy It is suggested that psoriatic arthritis is a chronic inflammatory autoimmune disease that targets both skin and nail and affects approximately 0.005 percent of the general population. [1] According to The American College of Rheumatology, current treatment for psoriatic arthritis includes non steroidal anti-inflammatory drugs, disease modifying anti-rheumatic…
https://blog.inpharmd.com/2015/10/07/secukinumab-inhibition-of-interleukin-17a-in-patients-with-psoriatic-arthritis/
Glycomet (Metformin) Order now just for 0.181667 per pill $ cheaprx.biz.stGlycomet (Metformin) Order now just for 0.181667 per pill $ cheaprx.biz.st
A concomitant use of metformin with forms of sulphonyl carbamide and insulin can result in hypoglycemia. Ethanol increases a risk of lacticacidemia, therefore you should avoid consuming alcohol. Cimetidine (Tagamet) is able to reduce the elimination of metformin from the body which results in increasing of the metformin amount in the blood by 40%. This may intensify side effects of metformin such as lacticemia. Derivatives of MAO inhibitors, β2-adrenergic receptor agonists, angiotensin-converting-enzyme inhibitors, cyclophosphamide, clonbratum, oxytetracycline, non steroidal anti-inflammatory drugs can potentiate the hypoglycemic effect of metformin. Chlorpromazine neuroleptic inhibits insulin release which can lead to the increasing of the metformin dosage applied only in case of total controlling of glucose level in the blood serum ...
http://cheaprx.biz.st/order-glycomet-online-en.html
Patent US4867985 - Spheroids - Google PatentsPatent US4867985 - Spheroids - Google Patents
A controlled release pharmaceutical composition contains a number of spheroids, the spheroids containing a water-insoluble drug dispersed in a controlled release matrix. The matrix contains between 70% and 99.5% (by weight) of microcrystalline cellulose, between 0.5% and 4% (by weight) of a cellulose derivative and, optionally, up to 26% of a sugar or a sugar alcohol. The water insoluble drug must dissolve in water (pH 5) at 20 C. to a concentration of less than 1.0 mg ml-1, preferably less than 0.5 mg ml-1. Preferred drugs are non-steroidal anti-inflammatory agents, especially fenprofen calcium, ibuprofen, ketoprofen, naproxen, diclofenac sodium, fenbufen, flurbiprofen, indomethancin, oxyphenbutazone, phenylbutazone or piroxicam.
http://www.google.com.au/patents/US4867985
Ketorolac Overview - Galen ReasonerKetorolac Overview - Galen Reasoner
Ketorolac is a non-steroidal anti-inflammatory agent demonstrating analgesic and anti-inflammatory activity. Ketorolac inhibits the cyclo-oxygenase enzyme essential for biosynthesis of prostaglandins. Ketorolac has been shown to reduce prostaglandin levels in the aqueous humour after topical ophthalmic administration.
https://www.galenreasoner.com/substances/ketorolac
Formulation of Ibuprofen Beads by Ionotropic GelationFormulation of Ibuprofen Beads by Ionotropic Gelation
Microencapsulation has become a common technique in the production of controlled release dosage forms. Many results have been reported, concerning the use of alginate beads as controlled release drug formulations. Alginate has a unique gel-forming property in the presence of multivalent cations, in an aqueous medium. Ibuprofen is an excellent analgesic and antipyretic, non-steroidal anti-inflammatory agent with a high therapeutic index. Formulation of ibuprofen in beads could reduce its gastric ulcerogenicity. Hence, in this study the formation of Ca-alginate ibuprofen beads, through ionotropic gelation has been investigated. For this purpose, different cross- linking agents including: Ca2+, Ba2+, Mn2+, Co2+, Sn2+ and Pb2+, were used for bead preparation. Next, characterization of the beads, size distribution, encapsulation efficiency of ibuprofen within the beads, the bead swelling and the drug release kinetic were investigated. Results showed that only Ca ion is suitable for the formation of ibuprofen
http://ijpr.sbmu.ac.ir/article_761.html
Analgin | LekhimAnalgin | Lekhim
Individual hypersensitivity to metamizole sodium and other pyrazolone derivatives. The attacks of asthma, rhinitis, conjunctivitis caused by acetylsalicylic acid or other non-steroidal anti-inflammatory drugs in history. Violation of blood (agranulocytosis, cytostatic or infectious neutropenia). Liver and/or kidney failure. Hereditary haemolytic anemia associated with deficiency gpyukozo-6-phosphate dehydrogenase. Abdominal pain of unknown origin. Anemia, leukopenia. Kidney diseases: pyelonephritis, glomerulonephritis, incl history. Should not be administered intravenously in patients with systolitic blood pressure below 100 mm Hg. Polytrauma. Shock.. ...
https://www.lekhim.ua/en/product/analgin
Flurbiprofen Drug Information - Indications, Dosage, Side Effects and PrecautionsFlurbiprofen Drug Information - Indications, Dosage, Side Effects and Precautions
Flurbiprofen(Ansaid) generic is a non-steroidal anti-inflammatory agent (NSAIA), prescribed for pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), inflammation of eye, dysmenorrhea. It prevents the production of irritant chemicals that cause pain, fever, and inflammation.
https://www.medindia.net/doctors/drug_information/flurbiprofen.htm
Dysmenorrhea - FemmePharmaDysmenorrhea - FemmePharma
Estimates indicate 50% of all women worldwide experience primary dysmenorrhea during or around the time of their period, and some prevalence rates indicate that as many as 90% of all women experience dysmenorrhea at some time in their lives. In the United States, it has been estimated that 100 million work hours are lost per year due to dysmenorrhea, which could translate into $2 billion in lost work productivity.. More than half of all women who experience primary dysmenorrhea indicate that their pain is moderate to severe in nature. Multiple treatments have been used throughout recent history to ameliorate dysmenorrhea, including herbal supplements, aspirin, non-steroidal anti-inflammatory agents, prescription pain medications and oral contraceptives.. In keeping with our dedication to developing pharmaceutical agents to treat diseases and disorders of women, FemmePharma Global Healthcare, Inc. is pursuing research and development of novel drug compounds to treat both primary dysmenorrhea and ...
http://femmepharma.com/about-us/development/dysmenorrhea/
Effects of the Nonsteroidal Anti-Inflammatory Drug Nepafenac on Sodium Channels in Cultured Mice Trigeminal Sensory Neurons |...Effects of the Nonsteroidal Anti-Inflammatory Drug Nepafenac on Sodium Channels in Cultured Mice Trigeminal Sensory Neurons |...
Purpose: : To investigate whether the ocular analgesic effects of nepafemac, a non-steroidal antiinflammatory drug, are mediated by a blockade of sodium currents in corneal peripheral endings of mouse trigeminal ganglion neurons. Methods: : Whole-cell patch-clamp recordings of sodium currents were made from adult mice trigeminal ganglion neurons. Neurons were isolated by a mechano-enzymatic dissociation procedure and kept in culture for 24-48 h. All recordings were performed at room temperature in small to medium size neurons. Drugs were applied by a gravity perfusion system. The effects of nepafenac and its active metabolite amfenac were compared with equivalent doses of diclofenac. Results: : Nepafenac (1-50 µM) had no effect on sodium currents. The active metabolite, amfenac (50 µM), produced a transient enhancement followed by a slow, modest decline, that did not reverse upon wash of the drug. In contrast, diclofenac (50 µM) produced a robust, reversible inhibition of sodium currents. ...
http://iovs.arvojournals.org/article.aspx?articleid=2392452
Other highlights in the July 6 Journal of the National Cancer Institute - RedorbitOther highlights in the July 6 Journal of the National Cancer Institute - Redorbit
A new study has found that long-duration regular use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen) may be associated with a reduced risk of prostate cancer. Use of aspirin and other NSAIDs has been consistently associated with a reduced risk of colorectal cancer in epidemiological studies, and aspirin reduced risk of colorectal polyp recurrence in two randomized trials. There has also been some evidence from laboratory and epidemiological studies that NSAIDs might influence prostate carcinogenesis, although the association is unclear. To determine whether use of NSAIDs is associated with a reduced risk of prostate cancer, Eric J. Jacobs, Ph.D., of the American Cancer Society in Atlanta, and colleagues studied more than 70,000 men participating in the American Cancer Societys Cancer Prevention Study II Nutrition Cohort. During the follow-up from 1992 to 1993 through August 2001, 4,853 cases of prostate cancer were diagnosed among these men. Current use of ...
http://www.redorbit.com/news/health/165433/other_highlights_in_the_july_6_journal_of_the_national/
DailyMed - LISINOPRIL AND HYDROCHLOROTHIAZIDE tabletDailyMed - LISINOPRIL AND HYDROCHLOROTHIAZIDE tablet
Hypotension - Patients on Diuretic Therapy: Patients on diuretics, and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril. The possibility of hypotensive effects with lisinopril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with lisinopril. If it is necessary to continue the diuretic, initiate therapy with lisinopril at a dose of 5 mg daily, and provide close medical supervision after the initial dose for at least two hours and until blood pressure has stabilized for at least an additional hour (See WARNINGS and DOSAGE AND ADMINISTRATION) When a diuretic is added to the therapy of a patient receiving lisinopril, an additional antihypertensive effect is usually observed (See DOSAGE AND ADMINISTRATION).. Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cd62e287-b648-459a-9414-621686c6b607
TROPINE MODULATORS OF 5-HT3 RECEPTOR - Patent applicationTROPINE MODULATORS OF 5-HT3 RECEPTOR - Patent application
0090]The compounds disclosed herein can also be administered in combination with other classes of compounds, including, but not limited to, anti-retroviral agents; CYP3A inhibitors; CYP3A inducers; protease inhibitors; adrenergic agonists; anti-cholinergics; mast cell stabilizers; xanthines; leukotriene antagonists; glucocorticoids treatments; local or general anesthetics; non-steroidal anti-inflammatory agents (NSAIDs), such as naproxen; antibacterial agents, such as amoxicillin; cholesteryl ester transfer protein (CETP) inhibitors, such as anacetrapib; anti-fungal agents, such as isoconazole; sepsis treatments, such as drotrecogin-α; steroidals, such as hydrocortisone; local or general anesthetics, such as ketamine; norepinephrine reuptake inhibitors (NRIs) such as atomoxetine; dopamine reuptake inhibitors (DARIs), such as methylphenidate; serotonin-norepinephrine reuptake inhibitors (SNRIs), such as milnacipran; sedatives, such as diazepham; norepinephrine-dopamine reuptake inhibitor ...
http://www.patentsencyclopedia.com/app/20100087364
Nuvo Research announces scientific presentation at the Annual Meeting of the American Medical Society for Sports Medicine |...Nuvo Research announces scientific presentation at the Annual Meeting of the American Medical Society for Sports Medicine |...
About SIS Shoulder impingement syndrome (SIS) is a common cause of shoulder pain and dysfunction and is typically caused by an impingement of the rotator cuff tendon. Persistent shoulder pain is a common reason for consulting with a primary care physician. Shoulder pain in adults aged ,70 years is estimated to be between 7% and 27%. The goals of treatment are to reduce pain and improve function so patients may fully participate in physical rehabilitation. In addition to physical therapy, the two most common medications used to treatment pain in SIS are non-steroidal anti-inflammatory agents (NSAIDs) and corticosteroid injections. About Synera Synera (lidocaine 70 mg/tetracaine 70 mg) topical patch is a combination amide and ester local anesthetic topical patch indicated for use on intact skin to provide local dermal analgesia for superficial venous access and superficial dermatological procedures such as excision, electrodessication and shave biopsy of skin lesions. Important Risk Information In ...
http://news.sys-con.com/node/2623639
Publication : USDA ARSPublication : USDA ARS
Citation: Smith, D.J., Huwe, J.K., Lorentzsen, M.K., Harrington, G.E. 2004. Biotransformation of [14c]-phenylbutazone after oral or intravenous administration to cattle. [abstract] American Chemical Society National Meeting, Philadelphia, PA, 8/22-26/2004, Picogram No. 67, Abstract No. 124. Interpretive Summary: Technical Abstract: Phenylbutazone (PBZ) is a non-steroidal anti-inflammatory agent that is sometimes used in an off-label manner by livestock producers. No withdrawal period has been established for phenylbutazone and no marker compound or tissue exists for PBZ in cattle. The objective of this study was to identify PBZ metabolites in cattle and to determine the identity of PBZ related residues in tissues. Urine samples were filtered, chromatographed, and metabolites analyzed by quadrapole time-of-flight MS. Tissue residues were extracted prior to analysis. Parent phenylbutazone was the major excretory product in cattle urine. Two ring-hydroxylated (phenolic) and three metabolites ...
https://www.ars.usda.gov/research/publications/publication/?seqNo115=166832
International Society for Cellular Medicine | www.cellmedsoc.orgInternational Society for Cellular Medicine | www.cellmedsoc.org
Pharmaceutical marketing also puts great pressure on physicians to use new products. The medical journal Hospital Practice pointed out that pharmaceutical company competition leads to very aggressive promotion and inundation of the physician with data supporting the use of each new drug. Such marketing may dilute opposing scientific information that is not as well publicised. Ultimately drugs may be withdrawn, but only after substantial harm has been done. For example, benoxaprofen, a non-steroidal anti-inflammatory agent (NSAID) was introduced and heavily marketed in 1982, but then withdrawn after cases of fatal liver toxicity were reported in Great Britain. Zomepirac sodium was also aggressively marketed as a safe analgesic, but withdrawn after a year and numerous reports of fatal anaphylaxis17. The cardiac drugs flecainide and encainide, heavily promoted to control abnormal heart rhythms, were then withdrawn years later after scientific studies showed they caused fatal arrythmias and that ...
http://www.cellmedsoc.org/health_news/hazards.htm
BRITISH MEDICAL JOURNAL Archives | Frank Magliochetti - Healthcare ReportBRITISH MEDICAL JOURNAL Archives | Frank Magliochetti - Healthcare Report
NSAIDs May Prevent the Development of Colorectal Cancer after Polyp Removal This post focuses on a recent study published in the British Medical Journal that suggests that NSAIDs may help prevent colorectal cancer after polyp removal - This post goes into more detail on the study. Frank Magliochetti Taking non-steroidal anti-inflammatory drugs (NSAIDs) may prevent the recurrence of advanced neoplasia, a type of polyp that is the precursor of colorectal cancer, after the surgical removal of pre-existing polyps. Recurrence rates of benign polyps and advanced neoplasia are quite high, so clinicians are eager to find easy-to-follow treatments to reduce recurrence. A team of scientists from across the United States recently collaborated with Mayo Clinic researchers to determine how well NSAIDs, aspirin and other supplements prevent the recurrence of precancerous or cancerous polyps. The results of the study, published in the British medical journal BMJ suggest NSAIDs may offer the greatest ...
http://frankmagliochettireport.com/index.php/tag/british-medical-journal/
Standalone Transoral Vertebroplasty for Treatment of Painful Metastatic C2 Lesion: A Case Report | Archives of Neuroscience |...Standalone Transoral Vertebroplasty for Treatment of Painful Metastatic C2 Lesion: A Case Report | Archives of Neuroscience |...
Metastatic involvement of the spine may present with pathologic fractures, deformity, neurologic deficit due to vertebral canal compromise, and pain. Pain is usually managed with non-steroidal anti-inflammatory agents, corticosteroid injections, calcitonin, etc. Since the introduction of percutaneous vertebroplasty in 1984, it has proven as an effective armamentarium in the management of painful metastatic spine lesions. Herein, we present a case of breast cancer with osteolytic C2 metastasis, for whom trans-oral vertebroplasty without posterior fusion resulted in long-standing pain control and maintenance of normal motions and stability. A 41-year-old woman, a known case of breast cancer with severe neck pain for three months, was admitted due to an osteolytic lesion in C2. The pain was incapacitating and resistant to conservative measures. Standalone transoral vertebroplasty resulted in pain control and a three-year follow-up showed durable control of pain. After positioning the patient and insertion
https://sites.kowsarpub.com/ans/articles/86148.html
SUBSTITUTED ETHANOLAMINES - Patent applicationSUBSTITUTED ETHANOLAMINES - Patent application
0156]The compounds disclosed herein can also be administered in combination with other classes of compounds, including, but not limited to, sepsis treatments, such as drotrecogin-α; antibacterial agents, such as ampicillin; antifungal agents such as terbinafine; anticoagulants, such as bivalirudin; thrombolytics, such as streptokinase; non-steroidal anti-inflammatory agents, such as aspirin; antiplatelet agents, such as clopidogrel; norepinephrine reuptake inhibitors (NRIs) such as atomoxetine; dopamine reuptake inhibitors (DARIs), such as methylphenidate; serotonin-norepinephrine reuptake inhibitors (SNRIs), such as milnacipran; sedatives, such as diazepham; norepinephrine-dopamine reuptake inhibitor (NDRIs), such as bupropion; serotonin-norepinephrine-dopamine-reuptake-inhibitors (SNDRIs), such as venlafaxine; monoamine oxidase inhibitors, such as selegiline; hypothalamic phospholipids; endothelin converting enzyme (ECE) inhibitors, such as phosphoramidon; opioids, such as tramadol; ...
http://www.patentsencyclopedia.com/app/20100009950
Finadyne oral paste - single syringeFinadyne oral paste - single syringe
Finadyne oral paste is off-white paste containing flunixin, non-steroidal anti-inflammatory agent used for alleviation of pain and inflammation in horses.
http://eastkentequine.uk/prescription-medication/pain_relief/finadyne_paste_syringe
XRAYS: Does aspirin lower a womans breast cancer risk?XRAYS: Does aspirin lower a womans breast cancer risk?
Women who take aspirin regularly may have a reduced risk of breast cancer. However, previous studies have reported mixed results-some suggest risk is lowered with aspirin while others do not see a protective effect. Few of these studies have looked at whether this potential benefit of aspirin is linked to specific types of breast cancer. This study found a modest reduction in breast cancer risk for women who took a low-dose aspirin at least three times per week, but only for one subtype of breast cancer. Women who took aspirin were less likely to develop ER/PR-positive/Her2- negative breast cancer, the most common type of breast cancer. This study found no breast cancer risk reduction for women who used regular-dose aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDS). (8/29/17)
http://www.facingourrisk.org/XRAYS/aspirin-and-breast-cancer-risk
HKU Scholars Hub: Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are...HKU Scholars Hub: Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are...
Background: Many patients who have had upper gastrointestinal bleeding continue to take low-dose aspirin for cardiovascular prophylaxis or other non-steroidal antiinflammatory drugs (NSAIDs) for musculoskeletal pain. It is uncertain whether infection with Helicobacter pylori is a risk factor for bleeding in such patients. Methods: We studied patients with a history of upper gastrointestinal bleeding who were infected with H. pylori and who were taking low-dose aspirin or other NSAIDs. We evaluated whether eradication of the infection or omeprazole treatment was more effective in preventing recurrent bleeding. We recruited patients who presented with upper gastrointestinal bleeding that was confirmed by endoscopy. Their ulcers were healed by daily treatment with 20 mg of omeprazole for eight weeks or longer. Then, those who had been taking aspirin were given 80 mg of aspirin daily, and those who had been taking other NSAIDs were given 500 mg of naproxen twice daily for six months. The patients in ...
http://repository.hku.hk/handle/10722/162562
Deracoxib | VCA Animal HospitalDeracoxib | VCA Animal Hospital
Deracoxib is a non-steroidal anti-inflammatory agent that is often used to relieve pain and inflammation after orthopedic surgery in dogs. It is also indicated for the treatment of chronic pain and lameness associated with osteoarthritis in dogs.
https://vcahospitals.com/know-your-pet/deracoxib
Immunomodulation of TLR2 and TLR4 by G2013 (alfa-L-Guluronic acid) in CVID PatientsImmunomodulation of TLR2 and TLR4 by G2013 (alfa-L-Guluronic acid) in CVID Patients
Background: Common variable immunodeficiency (CVID) is a primary immune disorder associated with hypogammaglobulinemia, recurrent infections and autoimmune diseases. CVID patients are frequently in contact with infectious pathogens leading to the activation of innate immunity through Toll-like receptors (TLR) affecting adaptive immunity. The aim of the present study was to test the immunomedulatory effect of small molecule G2013, a novel designed non-steroidal anti-inflammatory agent in CVID. Materials and Methods: After blood sampling from 16 CVID patients and 16 age- and sex-matched healthy controls, peripheral blood mononuclear cells (PBMCs) were isolated and treated with/without lipopolysaccharide (LPS), lipopolyteichoic acid (LTA), and G2013. Assessing the immunomodulatory effect of G2013, flowcytometry was done for quantify the protein expression of TLR2 and TLR4. Gene expressions of signaling molecules involved in the TLR2 and TLR4 pathways were assessed by real-time PCR. ELISA performed
http://ijp.mums.ac.ir/article_8745.html
Most recent papers with the keyword fibromyalgia in Diabetes Mellitus | Read by QxMDMost recent papers with the keyword fibromyalgia in Diabetes Mellitus | Read by QxMD
To evaluate glucose metabolism and/or insulin resistance (IR) in 96 patients with Fibromyalgia (FM), associated or not to cognitive impairment. We investigated glucose metabolism in 96 FM patients. Enrolled patients were divided into two groups: 48 patients with memory deficit (group A) and 48 without memory deficit (control group). We evaluated glucose and insulin levels after a 2 h-Oral-Glucose-Tolerance-Test (2 h-OGTT) and insulin resistance (IR) by the homeostasis model assessment formula (HOMA). Body Mass Index (BMI), waist-to-hip-ratio (WHR), anxiety level, fasting plasma insulin and Non-Steroidal Anti-Inflammatory agents use were higher in patients with FM with memory impairment; while age, sex, waist circumference, education level, fasting plasma glucose, glycate hemoglobin, triglycerides, blood lipid profile, C- Reactivity-Protein (CRP), blood pressure and smoking habits were similar in both groups ...
https://www.readbyqxmd.com/keyword/65244
Refill Prescription - 3Refill Prescription - 3
Millions of people throughout the world commonly take ibuprofen for minor aches and pains without thinking about the side effects the medication can have and other nonsteroidal anti-inflammatory drugs (NSAIDs) with an increased risk of cardiovascular problems, including heart attack and stroke, reports MedlinePlus. Learn more from WebMD about which medications might cause high blood pressure or interfere with your hypertension drugs. NSAIDs can also raise your risk for heart attack or stroke, especially in higher doses. Common NSAIDs that Decongestants may make your blood pressure and heart rate rise. It conducts the effects Do not take two doses together to make up for a painful dose.. ...
http://cuztomize.info/rell-prescription/index3.php
Pel-Ebstein fever - WikipediaPel-Ebstein fever - Wikipedia
Pel-Ebstein fever, also known as Ebstein-Cardarelli fever, is a rarely seen condition noted in patients with Hodgkins lymphoma in which the patient experiences fevers which cyclically increase then decrease over an average period of one or two weeks. A cyclic fever may also be associated with other conditions, but it is not called Pel-Ebstein fever unless the fever is associated with Hodgkins. The cause is currently unknown although speculation centers on host immune response - particularly the cyclical release of cytokines, lymph node necrosis, and damaged stromal cells. Treatment with non-steroidal anti-inflammatory agents or treatment of the underlying Hodgkins (usually with chemotherapy) will help the symptoms. The condition is named after Wilhelm Ebstein and P.K. Pel who both published papers in 1887 noting the phenomenon. Both doctors published in the same journal, though Pel published first by several months. Interestingly, a long-term dispute persisted between Pel and Ebstein on the ...
https://en.wikipedia.org/wiki/Pel-Ebstein_fever
Patent Publication November 4, 1981, Page 1Patent Publication November 4, 1981, Page 1
Directory of patents published on November 4, 1981 (1,499 patents): Method for winding several turns of wire on a case, in particular for the winding of deviation rings for cathode ray tubes, machine for carrying out the method and winding obtained by the method.; Solid state control for motor-generator welder.; Brake magnet for magnetic rail brakes of rail vehicles.; Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them.; Article carrier
http://patent.ipexl.com/date/19811104_1.html
Non steroidal anti inflammatory drugs naproxen | NSAIDs: Non-Steroidal Anti-Inflammatory Drugs - Spine-healthNon steroidal anti inflammatory drugs naproxen | NSAIDs: Non-Steroidal Anti-Inflammatory Drugs - Spine-health
NSAIDs have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects. Although different NSAIDs have different structures, they all work by blocking cyclooxygenase (COX) enzymes. There are two main
http://bdsb.steroids-australia.net/non-steroidal-anti-inflammatory-drugs-naproxen.html
Alginate-Graphene Oxide Biocomposite Sorbent for Rapid and Selective Extraction of Non-Steroidal Anti-Inflammatory Drugs Using...Alginate-Graphene Oxide Biocomposite Sorbent for Rapid and Selective Extraction of Non-Steroidal Anti-Inflammatory Drugs Using...
Alginate-Graphene Oxide Biocomposite Sorbent for Rapid and Selective Extraction of Non-Steroidal Anti-Inflammatory Drugs Using Micro-Solid Phase Extraction
https://jurnal.ugm.ac.id/ijc/article/view/38168
Analgesics and Ovarian Cancer Survival - The ASCO PostAnalgesics and Ovarian Cancer Survival - The ASCO Post
In a prospective cohort study reported in The Lancet Oncology, Melissa A. Merritt, PhD, of the University of Hawaii Cancer Centers Epidemiology Program, and colleagues found evidence that recent use of aspirin or nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) after diagnosis appears to improve ovarian cancer-specific survival.. The study involved data from the prospective Nurses Health Study (NHS) and Nurses Health Study II (NHSII) whose participants have completed biennial questionnaires since 1976 and 1989. Between June 1976 and May 2012 for the NHS and between June 1989 and May 2013 for NHSII, a total of 1,789 participants were diagnosed with epithelial ovarian cancer and 1,143 (64%) were eligible for inclusion in the current study; of these, 1,031 (90%) were included in the prediagnosis exposure analysis and 964 (84%) in the postdiagnosis analysis. Eligible participants had confirmed invasive stage I to III epithelial ovarian cancer and had data available on analgesic use. The ...
https://ascopost.com/issues/october-10-2018/analgesics-and-ovarian-cancer-survival/
The End of Modern Medicine? | GreenMedInfo | Blog EntryThe End of Modern Medicine? | GreenMedInfo | Blog Entry
Treating Pain is Becoming . . . a Pain. Modern medicines vulnerability in treating infection is not the only weakness that science has exposed recently. It has been a very bad couple of years for painkillers. Modern medicines failure to manage pain has been exposed. Important recent studies have cast serious doubt on the effectiveness and safety of painkillers.. Aspirin & Other Non-Steroidal Antiinflammatory Drugs (NSAID) Aspirin is a serious cause of ulcers and gastrointestinal bleeding. A meta-analysis of 24 controlled studies revealed that even taking a low dose of aspirin does not reduce the risk of gastrointestinal bleeding (BMJ 2000;321:1183-7). 28% of people who take low dose aspirin to prevent heart disease develop an ulcer (Ailementary Pharmacology & Therapeutics 2005;22:795-801).. Whats worse is that, despite this risk, aspirin doesnt even live up to its reputation for preventing heart disease. A recent study of people with multiple risk factors for atherosclerosis, including high ...
https://www.greenmedinfo.com/blog/end-modern-medicine
Indomethancin - Tocolytic Agents, Cardiovascular Agents, Anti-inflammatory Agents, Nonsteroidal...Indomethancin - Tocolytic Agents, Cardiovascular Agents, Anti-inflammatory Agents, Nonsteroidal...
Indomethacin, like other drugs of its class, is not free of side effects. The side effects of these drugs can cause discomfort and rarely, there are more serious side effects, such as gastrointestinal bleeding, which may result in hospitalization and even fatal outcomes. NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) are often essential agents in the management of arthritis, but they also may be commonly employed for conditions which are less serious. Physicians may wish to discuss with their patients the potential risks and likely benefits of NSAID treatment, particularly when the drugs are used for less serious conditions where treatment without NSAIDs may represent an acceptable alternative to both the patient and physician.. ...
https://pharmacycode.com/Indomethancin.html
Silent peptic ulcer disease: frequency, factors leading to silence, and implications regarding the pathogenesis of visceral...Silent peptic ulcer disease: frequency, factors leading to silence, and implications regarding the pathogenesis of visceral...
The results of this study suggest that silent peptic ulcer disease is common in Taiwan. Dyspeptic symptoms because of peptic ulcer disease may be influenced by intrinsic (body mass index and ulcer characters) and extrinsic (habitual tea drinking) factors. Non-steroidal anti-inflammatory drug use and …
https://pubmed.ncbi.nlm.nih.gov/15229422/?dopt=Abstract
Nenitzescu indole synthesisNenitzescu indole synthesis
Among them are serotonin, a neurotransmitter; indometacin, a non-steroidal anti-inflammatory agent; L-761,066, a COX-2 ...
https://en.wikipedia.org/wiki/Nenitzescu_indole_synthesis
Degenerative disc diseaseDegenerative disc disease
... oral analgesia with non-steroidal anti-inflammatory agents (NSAIDS); and topical analgesia with lidocaine, ice and heat. ... anti-inflammatory medications such as nonsteroidal anti-inflammatory drugs, traction, or epidural steroid injection often ...
https://en.wikipedia.org/wiki/Degenerative_disc_disease
BenoxaprofenBenoxaprofen
Somerville KW, Hawkey CJ (January 1986). "Non-steroidal anti-inflammatory agents and the gastrointestinal tract". Postgraduate ... Doube A (July 1990). "Hepatitis and non-steroidal anti-inflammatory drugs". Annals of the Rheumatic Diseases. 49 (7): 489-90. ... Dahl SL, Ward JR (1982). "Pharmacology, clinical efficacy, and adverse effects of the nonsteroidal anti-inflammatory agent ... Benoxaprofen had a considerably anti-inflammatory, analgesic and also anti-pyretic activity in those tests. In all six animals ...
https://en.wikipedia.org/wiki/Benoxaprofen
Diabetic retinopathyDiabetic retinopathy
Cochrane Eyes and Vision Group) (February 2015). "Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular ... steroidal anti‐inflammatory agents. Instead of laser surgery, some people require a vitrectomy to restore vision. A vitrectomy ... These three treatments are laser surgery, injection of corticosteroids or anti-VEGF agents into the eye, and vitrectomy. ... It is often more prudent to inject triamcinolone or anti-VEGF drugs. In some patients it results in a marked increase of vision ...
https://en.wikipedia.org/wiki/Diabetic_retinopathy
AmfenacAmfenac
... a non-steroidal anti-inflammatory agent". Journal of Pharmacobio-dynamics. 11 (9): 612-9. doi:10.1248/bpb1978.11.612. PMID ... Amfenac, also known as 2-amino-3-benzoylbenzeneacetic acid, is a nonsteroidal anti-inflammatory drug (NSAID) with acetic acid ...
https://en.wikipedia.org/wiki/Amfenac
Cochrane Eyes and VisionCochrane Eyes and Vision
Sivaprasad, Sobha; Bunce, Catey; Crosby-Nwaobi, Roxanne (2012-02-15). "Non-steroidal anti-inflammatory agents for treating ... and antiviral agents for herpes simplex virus. "Cataract in the Adult Eye PPP - 2016". American Academy of Ophthalmology. 2016- ...
https://en.wikipedia.org/wiki/Cochrane_Eyes_and_Vision
OxaprozinOxaprozin
... two novel series of non-steroidal anti-inflammatory agents. This article was published in Nature in 1968. In December 1988, ... Two Novel Series of Non-steroidal Anti-inflammatory Agents". Nature. 219 (5150): 164. Bibcode:1968Natur.219..164B. doi:10.1038/ ... Wang, Runsheng (6 Aug 2015). "Comparative efficacy of non-steroidal anti-inflammatory drugs in ankylosing spondylitis: a ... Following the filing of the patent, the first description of oxaprozin exhibiting anti-inflammatory properties was outlined in ...
https://en.wikipedia.org/wiki/Oxaprozin
Estradiol sulfateEstradiol sulfate
"Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents". Current Drug ...
https://en.wikipedia.org/wiki/Estradiol_sulfate
Ruscus aculeatusRuscus aculeatus
Ruscogenins function as anti-inflammatory agents and are also believed to cause constriction in veins. Currently the mode of ... The major phytochemicals in butcher's broom are steroidal saponins. Saponins occur naturally in plants as glycosides and have ... "Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear ... Sahu, N. P.; Banerjee, S.; Mondal, N. B.; Mandal, D. (2008), "Steroidal Saponins", Fortschritte der Chemie organischer ...
https://en.wikipedia.org/wiki/Ruscus_aculeatus
DitazoleDitazole
... is a non-steroidal anti-inflammatory agent with analgesic and antipyretic activity similar to phenylbutazone. It is ...
https://en.wikipedia.org/wiki/Ditazole
MeloxicamMeloxicam
"Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with ... Höglund OV, Dyall B, Gräsman V, Edner A, Olsson U, Höglund K (October 2018). "Effect of non-steroidal anti-inflammatory drugs ... Metacam is a prescription non-steroidal anti-inflammatory drug (NSAID) that is used to control pain and inflammation (soreness ... Meloxicam, sold under the brand name Mobic among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain ...
https://en.wikipedia.org/wiki/Meloxicam
Pel-Ebstein feverPel-Ebstein fever
Treatment with non-steroidal anti-inflammatory agents or treatment of the underlying Hodgkin's (usually with chemotherapy) will ...
https://en.wikipedia.org/wiki/Pel–Ebstein_fever
MycoremediationMycoremediation
... anti-epileptic and non-steroidal anti-inflammatory drugs; X-ray contrast agents; polycyclic musk fragrances; and ingredients of ... X-ray contrast agents, and ingredients of personal care products, can be broken down in a non-toxic way. Mycoremediation is a ...
https://en.wikipedia.org/wiki/Mycoremediation
Wikipedia:WikiProject Medicine/Cochrane/Cochrane Review List/Musculoskeletal, Oral, Skin and SensoryWikipedia:WikiProject Medicine/Cochrane/Cochrane Review List/Musculoskeletal, Oral, Skin and Sensory
Done Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular oedema PMID 25686158 https://doi.org/10.1002/ ... Done Anti-tumour necrosis factor biological therapies for the treatment of uveitic macular oedema (UMO) for non-infectious ... Done Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema PMID 29669176 ... Done Anti-vascular endothelial growth factor for choroidal neovascularisation in people with pathological myopia PMID 27977064 ...
https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Cochrane/Cochrane_Review_List/Musculoskeletal,_Oral,_Skin_and_Sensory
KetorolacKetorolac
Sivaprasad S, Bunce C, Crosby-Nwaobi R (February 2012). "Non-steroidal anti-inflammatory agents for treating cystoid macular ... "Topical non-steroidal anti-inflammatory drugs for analgesia in traumatic corneal abrasions". The Cochrane Database of ... "Prophylactic non-steroidal anti-inflammatory drugs for the prevention of macular oedema after cataract surgery". The Cochrane ... "Non-Steroidal Anti-Inflammatory Drugs and Aspirin Therapy for the Treatment of Acute and Recurrent Idiopathic Pericarditis". ...
https://en.wikipedia.org/wiki/Ketorolac
PleurisyPleurisy
Non-steroidal anti-inflammatory drugs (NSAIDs), preferably indometacin, are usually employed as pain control agents. A number ... The extract is thought to inhibit the same enzyme, cyclooxygenase-2 (COX-2), as the non-steroidal anti-inflammatory drugs. ... A couple of medications are used to relieve pleurisy symptoms: Paracetamol (acetaminophen) or anti-inflammatory agents to ... 1999). "Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice". Life Sci ...
https://en.wikipedia.org/wiki/Pleurisy
OleocanthalOleocanthal
Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils". Organic ... Similar to classical non-steroidal anti-inflammatory drugs, it is a non-selective inhibitor of cyclooxygenase (COX). 50 g (more ... a natural anti-inflammatory agent in extra virgin olive oils". Chem Senses. 34 (4): 333-9. doi:10.1093/chemse/bjp006. PMC ... "Against this background, the in vivo anti-inflammatory effects of dietary oleocanthal cannot be as relevant as hypothesized by ...
https://en.wikipedia.org/wiki/Oleocanthal
ChamomileChamomile
... is not recommended to be taken with aspirin or non-salicylate NSAIDs (non-steroidal anti-inflammatory drugs), as it ... Apigenin, a phytochemical in chamomile, may interact with anticoagulant agents and nonsteroidal anti-inflammatory drugs, while ... Chamomile is under preliminary research for its potential anti-anxiety properties. There is no high-quality clinical evidence ... scentless or false chamomile Chamomile may be used as a flavoring agent in foods and beverages, mouthwash, soaps, or cosmetics ...
https://en.wikipedia.org/wiki/Chamomile
Diphenylphosphoryl azideDiphenylphosphoryl azide
A new synthesis of some non-steroidal anti-inflammatory agents with the 2-arylpropionic acid skeleton by the use of diphenyl ...
https://en.wikipedia.org/wiki/Diphenylphosphoryl_azide
HU-308HU-308
... antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs) Karsak M, ... inflammatory response, and apoptosis (programmed cell death). HU-308 is also classified as a non-steroidal anti-inflammatory ... HU-308 has shown interesting properties such as anti-inflammatory, analgesic, neuroprotective, antitumor and anti-osteoporitic ... The antinociceptive and anti-inflammatory effects of HU-308, but not Δ8THC or CBD, were mediated through CB2R, and reduces ...
https://en.wikipedia.org/wiki/HU-308
Cystic kidney diseaseCystic kidney disease
Options include pain medication (except ibuprofen and other 'non-steroidal anti-inflammatory agents (NSAID's)' which may worsen ...
https://en.wikipedia.org/wiki/Cystic_kidney_disease
12-Hydroxyheptadecatrienoic acid12-Hydroxyheptadecatrienoic acid
... other non-steroidal anti-inflammatory agents (NSAID) in humans. Synthetic BLT2 agonists may be useful for speeding the healing ... Opposition between the pro-inflammatory LTB4/BLT1 and anti-inflammatory actions of the 12-HHT/BLT2 axes occurs in another ... exerting an anti-inflammatory activity". Experimental & Molecular Medicine. 44 (6): 378-86. doi:10.3858/emm.2012.44.6.043. PMC ... and other agents. BLT2 may ultimately prove to have binding specificity for a similarly broad range of agents. The production ...
https://en.wikipedia.org/wiki/12-Hydroxyheptadecatrienoic_acid
20-Hydroxyeicosatetraenoic acid20-Hydroxyeicosatetraenoic acid
... enzymes which metabolize 20-HETE such as non-steroidal anti-inflammatory agents, opioids, gemfibrozil, Lasix, propanol, and ... Many agents stimulate cells and tissues to produce 20-HETE in vitro and in vivo. Androgens are particularly potent stimulators ... There are a variety of pharmacological agents which inhibit the synthesis of 20-HETE including various fatty acid analogs that ... This metabolism-induced inactivation may underlie the proposed roles of the cytochromes in dampening inflammatory responses and ...
https://en.wikipedia.org/wiki/20-Hydroxyeicosatetraenoic_acid
AceglutamideAceglutamide
... on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese Journal of Pharmacology. ... Tanaka, H; Shuto, K; Marumo, H (1982). "Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, ... 35-. ISBN 978-0-8155-1856-3. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ... and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor ...
https://en.wikipedia.org/wiki/Aceglutamide
Prevention of dementiaPrevention of dementia
Hirohata M, Ono K, Naiki H, Yamada M (December 2005). "Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects ... It increases cerebral blood flow and is an anti-inflammatory agent, enhancing activity at the neuronal synapses in the brain. ... Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer's and Parkinson's diseases. The ... Etminan M, Gill S, Samii A (July 2003). "Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: ...
https://en.wikipedia.org/wiki/Prevention_of_dementia
Anti-inflammatoryAnti-inflammatory
More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... "Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis". British Medical Journal (Clinical ... Nonsteroidal anti-inflammatory drugs[edit]. Main article: Nonsteroidal anti-inflammatory drug. Nonsteroidal anti-inflammatory ... Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs ...
https://en.wikipedia.org/wiki/Anti-inflammatory
Nonsteroidal anti-inflammatory drugNonsteroidal anti-inflammatory drug
"Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury". Cochrane Database ... Jaturapatporn D, Isaac MG, McCleery J, Tabet N (February 2012). "Aspirin, steroidal and non-steroidal anti-inflammatory drugs ... "Non-steroidal anti-inflammatory drugs". British National Formulary. Retrieved 28 August 2019. Danelich IM, Wright SS, Lose JM, ... Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which ...
https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug
Idiopathic orbital inflammatory diseaseIdiopathic orbital inflammatory disease
... non-steroidal anti-inflammatory drugs, cytotoxic agents (chlorambucil, cyclophosphamide), corticosteroid sparing ... 121(4):491-9, 2003 Narla LD et al: Inflammatory Pseudotumor. RadioGraphics. 23(3):719-729, 2003 Belanger C et al: Inflammatory ... Idiopathic orbital inflammatory (IOI) disease, refers to a marginated mass-like enhancing soft tissue involving any area of the ... Idiopathic orbital inflammatory syndrome, also known as orbital pseudotumor, was first described by Gleason in 1903 and by ...
https://en.wikipedia.org/wiki/Idiopathic_orbital_inflammatory_disease
NephrologyNephrology
... nephrotoxins like radiologic contrast and non-steroidal anti-inflammatory drugs), antihypertensives, diet and weight ... Commonly used agents are prednisone, mycophenolate, cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and ... An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D ... Auto-immune and inflammatory kidney disease, such as vasculitis or transplant rejection, may be treated with immunosuppression ...
https://en.wikipedia.org/wiki/Nephrologist
GABAA receptor positive allosteric modulatorGABAA receptor positive allosteric modulator
This was shown when the anti-hyperalgesic action was reduced when administered in α2 and α3 mice in inflammatory pain and in ... In a rat brain slice preparation, the synthetic steroidal anesthetic alphaxalone (5α-pregnan-3α-ol-11,20 dione) enhanced both ... Sedative actions of benzodiazepines limit their usefulness as analgesic agents and they are therefore generally not considered ... Additionally, studies in α5 mice showed that the spinal α5-containing GABAA receptor has a minor role in inflammatory pain. An ...
https://en.wikipedia.org/wiki/GABAA_receptor_positive_allosteric_modulator
Acute inhalation injuryAcute inhalation injury
These include β2-agonists, dopamine, insulin, allopurinol, and non-steroidal anti-inflammatory drugs (NSAIDs), such as ... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ... These agents are less likely to produce early warning signs (phosgene in low concentrations has a pleasant odor), are more ...
https://en.wikipedia.org/wiki/Acute_inhalation_injury
Drug classDrug class
Strictly speaking, and also historically, the wider class of anti-inflammatory drugs also comprises steroidal anti-inflammatory ... not all triglyceride lowering agents are PPAR agonists, and not all drugs that are used to treat atherosclerosis are ... "nonsteroidal anti-inflammatory drugs" (NSAIDs) is thus composed by one element ("anti-inflammatory") that designates the ... The class of nonsteroidal anti-inflammatory drugs (NSAIDs) is one such example. ...
https://en.m.wikipedia.org/wiki/Drug_class
Arachidonate 5-lipoxygenaseArachidonate 5-lipoxygenase
Aspirin and other non-steroidal anti-inflammatory drugs (NSAID) can cause NSAID-exacerbated diseases (N-ERD). These have been ... Alox5 and presumably human ALOX5 functions may vary widely depending on the agents stimulating their and types of metabolites ... leukotriene production involved in inflammatory response. • leukotriene biosynthetic process. • inflammatory response. • ... Alox5 enzyme some of which possess opposing activities like the pro-inflammatory chemotactic factors and the anti-inflammatory ...
https://en.m.wikipedia.org/wiki/5-Lipoxygenase
ColostrumColostrum
... reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability". Clinical Science (London, ... turning it up when the body comes under attack from pathogens or other disease agents, and damping it when the danger is ... drugs and infectious microbes not only damages the gut but can lead to influx of damaging agents into the bloodstream. These ... through its immunoglobulin and other anti-microbial factors) and growth/healing factor constituents.[55] As pointed out by ...
https://en.m.wikipedia.org/wiki/Colostrum
AutoimmunityAutoimmunity
The details of parasite immune modulation are not yet known, but may include secretion of anti-inflammatory agents or ... Steroidal or NSAID treatment limits inflammatory symptoms of many diseases. IVIG is used for CIDP and GBS. Specific ... Treatments for autoimmune disease have traditionally been immunosuppressive, anti-inflammatory, or palliative.[8] Managing ... 2002) injected an anti-MHC Class II antibody into mice expressing a single type of MHC Class II molecule (H-2b) to temporarily ...
https://en.wikipedia.org/wiki/Autoimmune
Saline (medicine)Saline (medicine)
... non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics or topical anesthetics. Eye drops sometimes do not have medications ... Hypertonic saline-7% NaCl solutions are considered mucoactive agents and thus are used to hydrate thick secretions (mucus) in ...
https://en.wikipedia.org/wiki/Saline_
AspirinAspirin
... is used as an anti-inflammatory agent for both acute and long-term inflammation,[37] as well as for treatment of ... Verdoodt F, Friis S, Dehlendorff C, Albieri V, Kjaer SK (February 2016). "Non-steroidal anti-inflammatory drug use and risk of ... 1982). "Aspirin and similar analgesic and anti-inflammatory agents". Martindale: the extra pharmacopoeia (28th ed.). ... "FDA strengthens warning of heart attack and stroke risk for non-steroidal anti-inflammatory drugs". FDA. Archived from the ...
https://en.wikipedia.org/wiki/Acetylsalicylic_acid
HangoverHangover
Non-steroidal anti-inflammatory drugs such as aspirin or ibuprofen have been proposed as a treatment for the headaches ... Agents and Actions. 4 (2): 125-30. doi:10.1007/BF01966822. PMID 4842541.. ... "Anti-Hangover Tips". The Webtender. Retrieved 2010-03-26.. *^ McGregor NR (November 2007). "Pueraria lobata (Kudzu root) ...
https://en.wikipedia.org/wiki/Hangover
Diabetic nephropathyDiabetic nephropathy
Some of the most commonly used nephrotoxic medications are non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.[43 ... Glycemic control is maintained mainly with insulin in patients with Type 1 DM and with hypoglycemic agents and/or insulin in ... it is recommended that only one agent is used in patients with DM who have hypertension or any signs of microalbuminuria or ... Although RAAS blockade using more than one agent may further reduce proteinuria, the risk of adverse events (such as ...
https://en.wikipedia.org/wiki/Diabetic_nephropathy
阿司匹林 - 維基百科，自由的百科全書阿司匹林 - 維基百科，自由的百科全書
FDA Strengthens Warning of Heart Attack and Stroke Risk for Non-Steroidal Anti-Inflammatory Drugs. FDA. 2015-07-09 [2015-07-09] ... EF Reynolds (編). Aspirin and similar analgesic and anti-inflammatory agents. Martindale: The Extra Pharmacopoeia 28th: 234-82. ... Pharmacokinetic Solubility And Dissolution Profile of Non-Steroidal Anti-Inflammatory Drugs 2 (3). 2011.. ... Nonsteroidal anti-inflammatory drug-induced reactions and desensitization. J Asthma. 2004, 41 (4): 375-84. PMID 15281324. doi: ...
https://zh.wikipedia.org/zh-hant/阿斯匹林
Colorectal cancerColorectal cancer
Aspirin and other non-steroidal anti-inflammatory drugs decrease the risk.[2][11] Their general use is not recommended for this ... adding chemotherapy agents fluorouracil, capecitabine or oxaliplatin increases life expectancy. If the lymph nodes do not ... "Aspirin or Nonsteroidal Anti-inflammatory Drugs for the Primary Prevention of Colorectal Cancer". United States Department of ... Inflammatory bowel diseaseEdit. People with inflammatory bowel disease (ulcerative colitis and Crohn's disease) are at ...
https://en.m.wikipedia.org/wiki/Colon_cancer
COVID-19, a enciclopedia libreCOVID-19, a enciclopedia libre
"FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19". Drug Safety and Availability (en ... "International Journal of Antimicrobial Agents 55 (6): 105948. PMC 7156162. PMID 32201353. doi:10.1016/j.ijantimicag.2020.105948 ... Anti-tormenta de citocinas[editar , editar a fonte]. A tormenta de citocinas é unha condición médica que pode ser mortal e pode ... "Coronavirus, via libera dell'Aifa al farmaco anti-artrite efficace su 3 pazienti e a un antivirale: test in 5 centri" [ ...
https://gl.wikipedia.org/wiki/COVID-19
WHO Model List of Essential MedicinesWHO Model List of Essential Medicines
Non-opioids and non-steroidal anti-inflammatory medicines (NSAIMs)[edit]. A skeletal model of the chemical structure of aspirin ... Lipid-lowering agents[edit]. *Simvastatin[note 72]. Dermatological medicines (topical)[edit]. Antifungal medicines[edit]. * ... Not recommended for anti‐inflammatory use due to lack of proven benefit to that effect ... Anti-infective medicines[edit]. Anthelminthics[edit]. Intestinal anthelminthics[edit]. A skeletal model of the chemical ...
https://en.wikipedia.org/wiki/List_of_World_Health_Organization_Essential_Medicines
PrednisonePrednisone
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... Steroidal: 6β-Hydroxy-7α-thiomethylspironolactone. *7α-Acetylthio-17α-hydroxyprogesterone ... Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties.[32][33] Prednisone is ... "Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ...
https://en.wikipedia.org/wiki/Deltasone
IndometacinIndometacin
Main article: Non-steroidal anti-inflammatory drug. Indometacin, a non-steroidal anti-inflammatory drug (NSAID), has similar ... A New Non-steroid Anti-inflammatory Agent". British Medical Journal. 2 (5363): 965-70. doi:10.1136/bmj.2.5363.965. PMC 1873102 ... Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription ... As an NSAID, indometacin is an analgesic, anti-inflammatory, and antipyretic. Clinical indications for indometacin include:. ...
https://en.m.wikipedia.org/wiki/Indomethacin
ProstaglandinProstaglandin
Lethaby A, Duckitt K, Farquhar C (January 2013). "Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding". The ... but also neutralized the changes of the retina and the choroid thickness caused by the injection of pro-inflammatory agents. ... Tikhonovich MV, Erdiakov AK, Gavrilova SA (August 2018). "Nonsteroid anti-inflammatory therapy suppresses the development of ... Release of prostaglandins and other inflammatory mediators in the uterus cause the uterus to contract. These substances are ...
https://en.m.wikipedia.org/wiki/Prostaglandin
COX-2 inhibitorCOX-2 inhibitor
"Non-steroidal anti-inflammatory drugs for acute gout". The Cochrane Database of Systematic Reviews. 9: CD010120. doi:10.1002/ ... "Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents". Journal of the ... "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of ... The existing nonsteroidal anti-inflammatory drugs (NSAIDs) differ in their relative specificities for COX-2 and COX-1; while ...
https://en.wikipedia.org/wiki/COX_inhibitor
Mouth ulcerMouth ulcer
... non-steroidal anti-inflammatory drugs, nicorandil[11] (may be prescribed for angina) and propylthiouracil (e.g. used for ... Agent. Example(s) Viral. chickenpox, hand, foot and mouth disease, herpangina, herpetic stomatitis, human immunodeficiency ... Phenol is used during dental treatment as a cavity sterilizing agent and cauterizing material, and it is also present in some ... Numerous aphthous ulcers could be indicative of an inflammatory autoimmune disease called Behçet's disease. This can later ...
https://en.wikipedia.org/wiki/Mouth_ulcer
Anti-inflammatoryAnti-inflammatory
More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... "Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis". British Medical Journal (Clinical ... Nonsteroidal anti-inflammatory drugsEdit. Nonsteroidal anti-inflammatory drugs (NSAIDs) alleviate pain by counteracting the ... "List of 63 Anti-Inflammatory Foods to Choose from for Natural Healing". The Natural Anti-Inflammatory Remedies. Retrieved ...
https://en.m.wikipedia.org/wiki/Anti-inflammatory
AnesthesiaAnesthesia
On-demand pain medications typically include either opioid or non-steroidal anti-inflammatory drugs but can also make use of ... and inhalational anesthetic agents. For more invasive surgery, monitoring may also include temperature, urine output, blood ... as well as for accumulation of exhaled inhalational anesthetic agents, which might be deleterious to the health of operating ...
https://en.wikipedia.org/wiki/Anesthesia
COVID-19, ang malayang ensiklopedyaCOVID-19, ang malayang ensiklopedya
"FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19". Drug Safety and Availability (sa ... International Journal of Antimicrobial Agents (sa wikang Ingles). 55 (3): 105924. doi:10.1016/j.ijantimicag.2020.105924. ISSN ... "Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents". The Journal of Hospital ...
https://tl.m.wikipedia.org/wiki/Coronavirus_disease_2019
Alzheimers diseaseAlzheimer's disease
Long-term usage of non-steroidal anti-inflammatory drugs (NSAIDs) were thought in 2007 to be associated with a reduced ... Another similar agent is bapineuzumab, an antibody designed as identical to the naturally induced anti-amyloid antibody.[260] ... effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology". CNS & Neurological Disorders Drug Targets. ... Memantine is a noncompetitive NMDA receptor antagonist first used as an anti-influenza agent. It acts on the glutamatergic ...
https://en.m.wikipedia.org/wiki/Alzheimer's
Indometatsiin - VikipeediaIndometatsiin - Vikipeedia
Indometatsiin on mittesteroidsete põletikuvastaste ainete (MSPVA, inglise keeles non-steroidal anti-inflammatory drug ehk NSAID ... A New Non-steroid Anti-inflammatory Agent". Br Med J 2 (5363): 965-70. PMC 1873102. PMID 14056924. doi:10.1136/bmj.2.5363.965. ...
https://et.wikipedia.org/wiki/Indometatsiin
Copper peptide GHK-CuCopper peptide GHK-Cu
Because of the anti-inflammatory properties, copper-peptides could replace corticosteroids or non-steroidal anti-inflammatory ... In the late 1980s, copper peptide GHK-Cu started attracting attention as a promising wound healing agent. Pioneers in this ... GHK peptide has anti-inflammatory properties. Even though an exact mechanism remains unclear, in a recent study GHK and its ... antioxidant and anti-inflammatory effects, stimulation of collagen and glycosaminoglycan synthesis in skin fibroblasts and ...
https://en.wikipedia.org/wiki/Copper_peptide_GHK-Cu
Polyestradiol phosphatePolyestradiol phosphate
PEP may impair the effects of fibrates (e.g., bezafibrate) and certain nonsteroidal anti-inflammatory drugs (e.g., phenazone)[1 ... Steroidal: Alfatradiol. *Certain androgens/anabolic steroids (e.g., testosterone, testosterone esters, methyltestosterone, ... it very slowly releases the active agent estradiol over at least several months.[20][7] ... Treatment with estrogen has the highest incidence of gynecomastia, at 40 - 80%, anti-androgens, including flutamide, ...
https://en.wikipedia.org/wiki/Polyestradiol_phosphate
Peptic ulcer and non-steroidal anti-inflammatory agents. | GutPeptic ulcer and non-steroidal anti-inflammatory agents. | Gut
Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and ... was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of ... associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. ...
http://gut.bmj.com/content/27/8/929
Emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology | British Journal of OphthalmologyEmerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology | British Journal of Ophthalmology
The emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology. ... Emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology. Free ...
http://bjo.bmj.com/content/80/12/1117.1
Fulminating necrotizing fasciitis after intramuscular injection of a corticoid. Contributing role of non-steroidal anti...Fulminating necrotizing fasciitis after intramuscular injection of a corticoid. Contributing role of non-steroidal anti...
Contributing role of non-steroidal anti-inflammatory agents] ... Contributing role of non-steroidal anti-inflammatory agents] ...
https://pubmed.ncbi.nlm.nih.gov/8146835/
Influence of protein deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti...Influence of protein deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti...
... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ...
http://jpet.aspetjournals.org/content/217/3/776
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti...Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti...
... while they preserve or augment their anti-inflammatory activity, thus addressing significant risk factors for atherogenesis. ... Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), α-lipoic acid and indole-3-acetic acid with thiomorpholine were ... Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti- ... of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory ...
https://www.semanticscholar.org/paper/Amides-of-non-steroidal-anti-inflammatory-drugs-can-Theodosis-Nobelos-Kourti/12b13103450b8d4c18fd313b6dc1bb082e685cbe
A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory...A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory...
... application to the study of non-steroidal antiinflammatory agents. by Clyde A Takeguchi et al. ... 2,6-Di-tert-butyl-4-(2′-thenoyl)phenol(R-830): A novel nonsteroidal anti-inflammatory agent with antioxidant properties. * ... application to the study of non-steroidal antiinflammatory agents.. *. Clyde A Takeguchi, Charles J. Sih ... Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes.. *Christian ...
https://www.semanticscholar.org/paper/A-rapid-spectrophotometric-assay-for-prostaglandin-Takeguchi-Sih/dc15017fdc845c01ad8e0521ac65fe4c6446e182
EP 2329849 A1 - Combination Of Alpha-2 Adrenergic Receptor Agonist And Non-steroidal Anti-inflammatory Agent For Treating Or...EP 2329849 A1 - Combination Of Alpha-2 Adrenergic Receptor Agonist And Non-steroidal Anti-inflammatory Agent For Treating Or...
Combination Of Alpha-2 Adrenergic Receptor Agonist And Non-steroidal Anti-inflammatory Agent For Treating Or Preventing An ...
https://www.lens.org/lens/patent/EP_2329849_A1/family
Anti-Inflammatory Agents, Non-Steroidal | ISHAR OnlineAnti-Inflammatory Agents, Non-Steroidal | ISHAR Online
OBJECTIVE: To assess the effectiveness of conservative therapy in carpal tunnel syndrome. DATA SOURCES: A computer-aided search of MEDLINE and the Cochrane Collaboration was conducted for randomized controlled trials (RCTs) from January 1985 to May 2006. REVIEW METHODS: RCTs were included if: (1) the patients, with clinically and electrophysiologically confirmed carpal tunnel syndrome, had not previously undergone surgical release, (2) the efficacy of one or more conservative treatment options was evaluated, (3) the study was designed as a randomized controlled trial ...
http://isharonline.org/tags/anti-inflammatory-agents-non-steroidal
Temat: Anti-Inflammatory Agents, Non-Steroidal - OpacWWW - Prolib IntegroTemat: 'Anti-Inflammatory Agents, Non-Steroidal' - OpacWWW - Prolib Integro
Anti. -. Inflammatory. Agents. , Non. -. Steroidal. */adverse effects Anti. -. Inflammatory. Agents. , Non. -. Steroidal. */ ... Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /adverse effects ; Anti. -. Inflammatory. Agents. , Non. -. Steroidal. / ... Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /chemistry ; Anti. -. Inflammatory. Agents. , Non. -. Steroidal. / ... Anti. -. Inflammatory. Agents. /*adverse effects Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /*adverse effects ...
https://katalog.ue.wroc.pl/eds/search?q=%22Anti-Inflammatory+Agents%2C+Non-Steroidal%22&index=4
Adapalene - Anti-Inflammatory Agents, Non-Steroidal, Dermatologic Agents, ATC:D10AD03Adapalene - Anti-Inflammatory Agents, Non-Steroidal, Dermatologic Agents, ATC:D10AD03
... and inflammatory processes all of which represent important features in the pathology of acne vulgaris. ...
http://pharmacycode.com/Adapalene.html
Amodiaquine - Amebicides, Anti-Inflammatory Agents, Non-Steroidal, Antimalarials, ATC:P01BA06Amodiaquine - Amebicides, Anti-Inflammatory Agents, Non-Steroidal, Antimalarials, ATC:P01BA06
... has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. Amodiaquine is at least as ...
http://pharmacycode.com/Amodiaquine.html
LISINOPRIL TABLETS, USPRx onlyLISINOPRIL TABLETS, USPRx only
Non-steroidal Anti-inflammatory Agents: In some patients with comprised renal function who are being treated with non-steroidal ... Other Agents: Lisinopril has been used concomitantly with nitrates and/or digoxin without evidence of clinically significant ... Agents Increasing Serum Potassium: Lisinopril attenuates potassium loss caused by thiazide-type diuretics. Use of lisinopril ... anti-inflammatory drugs, the co-administration of lisinopril may result in further deterioration of renal function. These ...
https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=26558
DailyMed - LISINOPRIL- lisinopril tabletDailyMed - LISINOPRIL- lisinopril tablet
Non-Steroidal Anti-Inflammatory Agents In a study in 36 patients with mild to moderate hypertension where the antihypertensive ... 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) 7.4 Dual Blockade ... 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who ... Hypoglycemia: Tell diabetic patients treated with oral antidiabetic agents or insulin starting an ACE inhibitor to monitor for ...
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8ad5c56-0368-fbb5-290d-c32d19b8ab06
Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study. - PubMed...Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study. - PubMed...
Anti-Inflammatory Agents, Non-Steroidal. LinkOut - more resources. Full Text Sources. *Wiley ... Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study.. Ofori B1 ... Many women take non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain ...
https://www.ncbi.nlm.nih.gov/pubmed/16929547?dopt=Abstract
Electronic Health Record (EHR)-Based Intervention for Gastroesophageal Reflux Disease (GERD) and Chronic Non-steroidal Anti...Electronic Health Record (EHR)-Based Intervention for Gastroesophageal Reflux Disease (GERD) and Chronic Non-steroidal Anti...
Anti-Inflammatory Agents. Anti-Inflammatory Agents, Non-Steroidal. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents ... and Chronic Non-steroidal Anti-inflammatory Drug (NSAID) Use. The safety and scientific validity of this study is the ... and for gastroprotection for patients on chronic non-steroidal anti-inflammatory drugs (NSAIDs) at increased risk for upper GI ... nonsteroidal anti-inflammatory drugs. peptic ulcer. Diagnosed GERD. Atypical GERD symptoms. chronic NSAID therapy. Risk for ...
https://clinicaltrials.gov/ct2/show/NCT00691171
Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti...Efficacy and Safety of TAK-438 for the Prevention of Recurrent Gastric or Duodenal Ulcers During Therapy of Non-steroidal Anti...
Anti-Inflammatory Agents. Lansoprazole. Dexlansoprazole. Anti-Inflammatory Agents, Non-Steroidal. Anti-Ulcer Agents. ... Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Antirheumatic Agents. ... in patients with a history of gastric or duodenal ulcer who require long-term therapy of non-steroidal anti-Inflammatory drug ( ... for the Prevention of Recurrent Gastric or Duodenal Ulcers During Long-term Therapy of Non-steroidal Anti-inflammatory Drug ( ...
https://clinicaltrials.gov/ct2/show/NCT01452750?recr=Open&cond=%22Duodenal+Ulcer%22&rank=8
A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory...A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory...
Anti-Inflammatory Agents, Non-Steroidal. Anti-Inflammatory Agents. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents ... Active Comparator: Non-steroidal Anti-inflammatory Drug (NSAIDs) Participants will receive fixed dose combination of tramadol ... A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory ... plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants ...
https://www.clinicaltrials.gov/ct2/show/NCT00635349?term=TRAMADOL&
Diclofenac Sodium Topical : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMDDiclofenac Sodium Topical : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
More Resources for Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical. *Find Lowest Prices on ... How to use Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical. Read the Medication Guide provided by ... List Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical side effects by likelihood and severity. ... What should I know regarding pregnancy, nursing and administering Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents ...
https://www.webmd.com/drugs/2/drug-22221-4289/diclofenac-sodium-topical/diclofenac-3-topical/details
Asacol HD (Mesalamine Delayed-Release Tablets, Oral): Side Effects, Interactions, Warning, Dosage & UsesAsacol HD (Mesalamine Delayed-Release Tablets, Oral): Side Effects, Interactions, Warning, Dosage & Uses
Nephrotoxic Agents, Including Non-Steroidal Anti-Inflammatory Drugs. The concurrent use of mesalamine with known nephrotoxic ... agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of renal reactions [see WARNINGS AND ... releasing mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon. Mesalamine (also ... as active inflammatory bowel disease is also associated with adverse pregnancy outcomes. ...
https://www.rxlist.com/asacol-hd-drug.htm
Delzicol (Mesalamine Delayed-Release Capsules): Side Effects, Interactions, Warning, Dosage & UsesDelzicol (Mesalamine Delayed-Release Capsules): Side Effects, Interactions, Warning, Dosage & Uses
Nephrotoxic Agents, Including Non-Steroidal Anti-Inflammatory Drugs. The concurrent use of mesalamine with known nephrotoxic ... agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of renal reactions [see WARNINGS AND ... which dissolves at pH 7 or greater and releases mesalamine in the terminal ileum and beyond for topical anti-inflammatory ... as active inflammatory bowel disease is also associated with adverse pregnancy outcomes. ...
https://www.rxlist.com/delzicol-drug.htm
Non-steroidal anti-inflammatory a... preview & related info | MendeleyNon-steroidal anti-inflammatory a... preview & related info | Mendeley
Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. ... Grabosch, S. M., Shariff, O. M., Wulff, J. L., & Helm, C. W. (2014, April 9). Non-steroidal anti-inflammatory agents to induce ... Objectives: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including ...
https://www.mendeley.com/catalogue/f24423ef-483d-3ad8-97f0-4cc8321bb2e4/
Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory agents. | IMSEARComparative pharmacology of tromaril with other common non-steroidal anti-inflammatory agents. | IMSEAR
Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory agents. ... Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory age ... Anti-Inflammatory Agents Language: English Year: 1985 Type: Article ... Anti-Inflammatory Agents Language: English Year: 1985 Type: Article ...
https://search.bvsalud.org/gim/resource/en/sea-16928
Micardis HCT - FDA prescribing information, side effects and usesMicardis HCT - FDA prescribing information, side effects and uses
Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors. Telmisartan. Non-Steroidal Anti- ... Administration of a non-steroidal anti-inflammatory agent, including a selective COX‑2 inhibitor, can reduce the diuretic, ... Therefore, when MICARDIS HCT and non-steroidal anti-inflammatory agents including selective COX‑2 inhibitors are used ... aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). *potassium supplements or a salt substitute containing ...
https://www.drugs.com/pro/micardis-hct.html
WHO HQ Library catalog › Results of search for su:{Anti-inflammatory agents, Non-steroidal}WHO HQ Library catalog › Results of search for 'su:{Anti-inflammatory agents, Non-steroidal}'
Results of search for su:{Anti-inflammatory agents, Non-steroidal} No results found! No results found for that in WHO HQ ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BAnti-inflammatory%20agents,%20Non-steroidal%7D
Side Effects of Accupril (quinapril): Interactions & WarningsSide Effects of Accupril (quinapril): Interactions & Warnings
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who are ... Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effects of ACE inhibitors. ... Other Agents. Drug interaction studies of Accupril with other agents showed:. *Multiple dose therapy with propranolol or ... Agents That Inhibit mTOR. Patients taking concomitant mTOR inhibitor (e.g. temsirolimus) therapy may be at increased risk for ...
https://www.medicinenet.com/side_effects_of_accupril_quinapril/side-effects.htm
Side Effects of Mavik (trandolapril): Interactions & WarningsSide Effects of Mavik (trandolapril): Interactions & Warnings
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who are ... Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effects of Mavik. ... Antidiabetic Agents. Concomitant use of ACE inhibitors and antidiabetic medicines (insulin or oral hypoglycemic agents) may ... Agents Increasing Serum Potassium. Trandolapril can attenuate potassium loss caused by thiazide diuretics and increase serum ...
https://www.medicinenet.com/side_effects_of_mavik_trandolapril/side-effects.htm
Olmesartan Medoxomil - FDA prescribing information, side effects and usesOlmesartan Medoxomil - FDA prescribing information, side effects and uses
Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who are ... Agents Increasing Serum Potassium. Concomitant use of olmesartan with other agents that block the renin-angiotensin system, ... Bile Acid Sequestering Agent Colesevelam. Concomitant administration of 40 mg Olmesartan Medoxomil and 3750 mg colesevelam ... Closely monitor blood pressure, renal function and electrolytes in patients on Olmesartan Medoxomil and other agents that ...
https://www.drugs.com/pro/olmesartan-medoxomil.html
Non-Steroidal Anti-Inflammatory Drugs NSAIDs | GreenMedInfo | ToxicNon-Steroidal Anti-Inflammatory Drugs NSAIDs | GreenMedInfo | Toxic
This topic contains 105 study abstracts on Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) indicating it may contribute to ... Anti-Inflammatory Agents. Additional Keywords : Natural Substances Versus Drugs. Problem Substances : Non-Steroidal Anti- ... 21 Adverse Pharmacological Actions Researched for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Name. AC. CK. Focus. ... 4 Abstracts with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) & Rheumatoid Arthritis Research. [x] Remove Focus on Rheumatoid ...
http://www.greenmedinfo.com/toxic-ingredient/non-steroidal-anti-inflammatory-drugs-nsaids?ed=4226
Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal...Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal...
To evaluate this traditional medicinal effect, we investigated the anti-chronic infl … ... Keywords: Anti-chronic inflammatory activity; Cellular senescence; Homoisoflavone; Ophiopogon japonicus; SASP; Steroidal ... Anti-Inflammatory Agents / pharmacology * Anti-Inflammatory Agents / therapeutic use* * Cellular Senescence / drug effects* ... Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal ...
https://pubmed.ncbi.nlm.nih.gov/29961188/
PAIN+ CPN | Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft...PAIN+ CPN | Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft...
Jones P, Lamdin R, Dalziel SR Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft ... The best drug treatment for such injuries is not certain, although non-steroidal anti-inflammatory drugs (NSAIDs) are often ... The applicability of findings from these studies is in question because the dextropropoxyphene combination analgesic agents ...
https://www.painpluscpn.ca/Home/Article/98529
NSAIDsDrugsTopicalNSAIDAnalgesicCytokinesMediatorsAspirinIbuprofenRheumatoid ArthritisPharmacologicalInhibitRatsMedicinal ChemistryMedicationsCombination with other antihypertensive agentsCompositionsAntihypertensive agentsInduceMicrovascularDrugPeptic ulcerDerivativesAcetaminophenPharmacologyClinicalTherapeuticReceptorsEffectsAcuteResponsesActivityPharmaceuticalComprisesStudy
NSAIDs31
  • Many women take non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain controversial. (nih.gov)
  • The purpose of the study is to examine the impact of augmented, high-quality physician-coordinated care executed via an electronic health record (EHR)-based intervention on quality of care for gastroesophageal reflux disease (GERD) and for gastroprotection for patients on chronic non-steroidal anti-inflammatory drugs (NSAIDs) at increased risk for upper GI tract ulcers and ulcer related complications. (clinicaltrials.gov)
  • The purpose of this study is to compare the effectiveness of tramadol hydrochloride 37.5 milligram (mg) plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants with knee osteoarthritis (a progressive and degenerative joint disease, in which the joints become painful and stiff) whose pain was relieved after the add-on treatment of tramadol hydrochloride to NSAIDs. (clinicaltrials.gov)
  • Objectives: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, to induce regression and prevent the progression of cervical intraepithelial neoplasia CIN. (mendeley.com)
  • Aspirin and other nonsteroidal anti-inflammatory drugs ( NSAIDs ) may reduce the effects of ACE inhibitors. (medicinenet.com)
  • Exposure to non-steroidal anti-inflammatory drugs (NSAIDs) is known to increase substantially the risk of upper gastrointestinal bleeding and perforation (UGIB). (nih.gov)
  • The present study was designed to investigate human gastric blood flow during administration of non-steroidal anti-inflammatory drugs (NSAIDs) by harmonic flash echo imaging. (biomedsearch.com)
  • The best drug treatment for such injuries is not certain, although non-steroidal anti-inflammatory drugs (NSAIDs) are often recommended. (painpluscpn.ca)
  • The present invention relates generally to pharmaceutical preparations and medical treatment methods, and more particularly agents (i.e, urea and urea derivatives, nonsteroidal anti-inflammatory drugs (NSAIDS) and anti-metabolite drugs) used alone or in combinations with each other (or with other agents) to treat or prevent certain disorders of the eye. (google.com.au)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), both nonselective and cyclooxygenase-2-specific inhibitors, are commonly used medications for the relief of acute and chronic pain associated with a wide range of medical conditions. (nih.gov)
  • We also reviewed the literature to assess the risks and effectiveness of nonsteroidal anti-inflammatory drugs (NSAIDs), which are often used as the "conventional" first-line treatment for similar musculoskeletal conditions. (chiro.org)
  • Background: Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). (eurekaselect.com)
  • Background Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of heart failure. (bmj.com)
  • Introduction: Currently, the diagnosis of nonsteroidal antiinflammatory drugs (NSAIDs) hypersensivitity is based on patients´ clinical history and drug provocation tests, which are done in selected cases. (usp.br)
  • Conditions › Back Pain › Low Back Pain › Non-steroidal Anti-inflammatory Drugs (NSAIDs) in the Treatm. (spineuniverse.com)
  • Aspirin is the prototypical member of the group of medications known as non-steroidal anti-inflammatory drugs (NSAIDs) . (spineuniverse.com)
  • A reduction in their local concentration could therefore explain the combined anti-inflammatory and analgesic properties of NSAIDs. (spineuniverse.com)
  • Most NSAIDs do not decrease the production of lipoxygenase-produced leukotrienes (causes inflammation and allergic reactions), which are also believed to significantly contribute to the inflammatory response. (spineuniverse.com)
  • A disparity between the anti-inflammatory and analgesic potencies of these agents in clinical practice has been observed, and recent data has suggested that pain relief from NSAIDs may in part be secondary to a more central anti-nociceptive component. (spineuniverse.com)
  • With the recently expanded sales and marketing of over-thecounter ibuprofen and naproxen, additional increases in the already widespread use of nonsteroidal antiinflammatory drugs (NSAIDs) [3] is likely. (thefreelibrary.com)
  • With the exception of acetaminophen and tramadol, the above analgesics, also classified as NSAIDs, are indicated for the treatment of acute or chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute pericarditis, and Kawasaki's disease. (thefreelibrary.com)
  • The most common causes are bacteria and use of nonsteroidal anti-inflammatory drugs ( NSAIDs ). (medicalnewstoday.com)
  • Epidemiological studies suggest reduced AD risk associates with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). (jneurosci.org)
  • ABSTRACT: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and consumed drug classes, they are associated with a wide range of adverse effects, including NSAID-induced hypersensitivity reactions (NHRs). (uspharmacist.com)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used analgesic, anti-inflammatory, and antipyretic medications on the market. (uspharmacist.com)
  • To evaluate the effect of the topical steroid, fluorometholone, and the non-steroidal anti-inflammatory drugs (NSAIDs), nepafenac and ketorolac, on inflammatory cytokine expression of the ocular surface in the botulium toxin B-induced murine dry eye model. (molvis.org)
  • Topical fluorometholone caused suppression of inflammatory cytokine expression on the ocular surface in the Botulium toxin B-induced murine dry eye model, while topical NSAIDs demonstrated no clearly beneficial effects. (molvis.org)
  • Several epidemiological studies have demonstrated a reduced risk for AD in patients using nonsteroidal anti-inflammatory drugs (NSAIDs), prompting further inquiries about how NSAIDs might influence the development of AD pathology and inflammation in the CNS. (jneurosci.org)
  • Background NSAIDs are popular and used as analgesics, antipyretics and anti-inflammatory agents for more than a century. (bmj.com)
  • CSIs are equivalent to non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory agents. (mja.com.au)
  • are they safer than non-steroidal anti-inflammatory drugs (NSAIDs) in patients with hypertension and renal impairment? (mja.com.au)
Drugs21
  • Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity. (semanticscholar.org)
  • Association of Aspirin and Other Nonsteroidal Anti - inflammatory Drugs With Vertebral Trabecular Bone: Data From Multiethnic Study of Atherosclerosis, a Population-Based Multicenter Cohort Study. (wroc.pl)
  • Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study. (nih.gov)
  • Nonsteroidal anti-inflammatory drugs (including diclofenac ) may rarely increase the risk for a heart attack or stroke . (webmd.com)
  • Some nonsteroidal antiinflammatory drugs can significantly increase C-reactive protein levels. (greenmedinfo.com)
  • Reduced conscious blood flow in the stomach during non-steroidal anti-inflammatory drugs administration assessed by flash echo imaging. (biomedsearch.com)
  • Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. (painpluscpn.ca)
  • Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. (springer.com)
  • The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. (cancer.gov)
  • Many drugs are available in the market for inflammatory diseases. (hindawi.com)
  • Inflammatory diseases are mainly treated with nonsteroidal anti-inflammatory drugs and steroidal drugs [ 1 ]. (hindawi.com)
  • To estimate peptic ulcer prevalence in 10 years-interval and compare the association with H. pylori and use of non-steroidal anti-inflammatory drugs. (scielo.br)
  • Records assessment in two periods: A (1997-2000) and B (2007-2010), searching for peptic ulcer, H. pylori infection and non-steroidal anti-inflammatory drugs use. (scielo.br)
  • Peptic ulcer occurred in 30.35% in A and in 20.19% in B. H. pylori infection occurred in 73.3% cases in A and in 46.4% in B. Non-steroidal anti-inflammatory drugs use was 3.5% in A and 13.3% in B. Neither condition occurred in 10.4% and 20.5% in A and B respectively. (scielo.br)
  • Comparing both periods, we observed reduction of peptic ulcer associated to H. pylori ( P =0.000), increase of peptic ulcer related to non-steroidal anti-inflammatory drugs ( P =0.000) and idiopathic peptic ulcer ( P =0.002). (scielo.br)
  • The concurrent association of H. pylori and non-steroidal anti-inflammatory drugs was also higher in B ( P =0.002). (scielo.br)
  • After 10 years, the prevalence of peptic ulcer decreased, as well as ulcers related to H. pylori whereas ulcers associated to non-steroidal anti-inflammatory drugs increased. (scielo.br)
  • Analgesic drugs comprise the largest category of pharmaceutical agents consumed by individuals in the United States. (thefreelibrary.com)
  • One major concern is that the analgesic class of drugs accounted for more exposures reported to the American Association of Poison Control Centers in 1995 than did any other category of pharmaceutical agents (3). (thefreelibrary.com)
  • Side effect issues could be overcome using alternative anti-inflammatory drugs directed against different inflammatory targets. (jneurosci.org)
  • The availability of the COX-2-specific inhibitor (CSI) class of anti-inflammatory drugs, namely celecoxib and rofecoxib, has raised a number of questions. (mja.com.au)
Topical5
  • The inner coat consists of an acrylic based resin, Eudragit S, which dissolves at pH 7 or greater, releasing mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon . (rxlist.com)
  • DELZICOL (mesalamine) delayed-release capsules contain acrylic based resin, Eudragit S (methacrylic acid copolymer type B, NF), which dissolves at pH 7 or greater and releases mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon . (rxlist.com)
  • Pre-operative use of the topical steroidal and non-steroidal anti-inflammatory agents to maintain intra-operative mydriasis during cataract surgery. (bvsalud.org)
  • This paper summarizes the currently accepted concepts of the pathogenetic mechanisms underlying the morphological and functional changes in intranasal mucosa of the patients having a long history of the application of the long-acting topical vasoconstrictor agents. (bireme.br)
  • This current study was designed to investigate whether topical fluorometholone, ketorolac and nepafenac inhibit inflammatory cytokine expression on the ocular surface in the BTX-B-induced murine dry eye model. (molvis.org)
NSAID4
  • Diclofenac is known as a nonsteroidal anti-inflammatory drug (NSAID). (webmd.com)
  • The dosing and cost of each NSAID varies significantly by chemical family and agent. (spineuniverse.com)
  • The present invention is directed to a pharmaceutical composition and method for the treatment of rhinitis and cold-like symptoms which includes a non-steroidal anti-inflammatory drug (NSAID), a decongestant, and an antihistamine. (google.com)
  • It has been found that an NSAID enhances the activity of a decongestant and an anti-histamine, thus permitting a reduction in either or both in administration of separate dosage forms. (google.com)
Analgesic2
  • The applicability of findings from these studies is in question because the dextropropoxyphene combination analgesic agents used are no longer in general use. (painpluscpn.ca)
  • Have analgesic, anti-inflammatory, and antipyretic activities. (medscape.com)
Cytokines4
  • Synergistic enhancement of production of proinflammatory cytokines of human peripheral blood monocytes by anti-Sm and anti-RNP antibodies. (bioportfolio.com)
  • In our previous study, the oxLDL/βGPI/anti-βGPI complex was demonstrated to further enhance the foam cell formation and migration of VSMC, as well as the expression of inflammatory cytokines, via th. (bioportfolio.com)
  • The pro-inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were evaluated by immunohistochemistry. (molvis.org)
  • The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits. (jneurosci.org)
Mediators5
  • During an inflammatory response, mediators such as various inflammatory mediators are released into the rat paw tissue, such as prostaglandins (PGE2), leukotrienes (LTD4), nitric oxide (NO), and oxygen reactive species. (hindawi.com)
  • These inflammatory mediators have potential to continue stimulating the inflammatory response and its perpetuation [ 2 ]. (hindawi.com)
  • These events are induced by inflammatory mediators which bind to specific receptors on inflammatory and endothelial cells. (hindawi.com)
  • Prostaglandins are active mediators of the inflammatory cascade, which also serve to sensitize peripheral nociceptors (nerve endings). (spineuniverse.com)
  • COX-1 inhibition shifts the arachidonic acid pathway from the production of the protective anti-inflammatory prostaglandins toward the production of the proinflammatory mediators, eosinophils, and mast cells. (uspharmacist.com)
Aspirin3
  • Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. (bmj.com)
  • There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. (bmj.com)
  • The most common antiplatelet agent prescribed is a small dose of aspirin (Aspec®, Cartia®, Cardiprin® and others). (dermnetnz.org)
Ibuprofen5
  • Anti-inflammatory doses of ibuprofen: effect on neutrophils and exercise-induced muscle injury. (biomedsearch.com)
  • The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2* production, and markers of muscle injury. (biomedsearch.com)
  • In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise. (biomedsearch.com)
  • Ibuprofen also decreased the numbers of ubiquitin-labeled dystrophic neurites and the percentage area per plaque of anti-phosphotyrosine-labeled microglia. (jneurosci.org)
  • Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD. (jneurosci.org)
Rheumatoid Arthritis1
  • Sulfasalazine (SSZ) is a commonly used drug in the treatment of inflammatory diseases such as rheumatoid arthritis and Crohn's disease. (tudelft.nl)
Pharmacological2
  • Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. (pharmacycode.com)
  • Induction of TH typically requires a multimodal approach, including the use of both pharmacological agents and physical techniques. (frontiersin.org)
Inhibit1
  • Antiplatelet agents inhibit the production of thromboxane. (dermnetnz.org)
Rats3
  • Influence of protein deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in rats. (aspetjournals.org)
  • In the present study, we examined the anti-inflammatory effects of dried fruit methanol extract on carrageenan-induced hind paw edema in rats. (hindawi.com)
  • Diosgenin Protects Rats from Myocardial Inflammatory Injury Induced by Ischemia-Reperfusion. (bioportfolio.com)
Medicinal Chemistry1
  • Each issue of Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry affords the reader with timely reviews on current topics, which are invaluable to those engaged in particular areas of research and those wanting to update their knowledge in areas outside of their expertise. (benthamscience.com)
Medications1
  • Because of the extensive use of these agents, adverse events that occur infrequently may still affect the overall risk/benefit ratio of this class of medications. (nih.gov)
Combination with other antihypertensive agents2
  • Micardis HCT may be used alone or in combination with other antihypertensive agents. (drugs.com)
  • Captopril is effective alone and in combination with other antihypertensive agents, especially thiazide -type diuretics . (wikidoc.org)
Compositions1
  • Topically applicable compositions in the form of oil-in-water (O/W) emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable emulsifying system and at least one active agent of the family of steroidal anti-inflammatory agents, and are useful e.g., for the treatment of psoriasis. (freepatentsonline.com)
Antihypertensive agents1
  • Olmesartan may be administered with other antihypertensive agents. (wikidoc.org)
Induce1
  • These proinflammatory agents can then induce the overproduction of cysteinyl leukotrienes (CysLTs), which causes an increase of CysLTs receptor expression in the bronchial muscles, as well as the endothelial and epithelial cells. (uspharmacist.com)
Microvascular1
  • Acute rat paw inflammation is caused by the migration of inflammatory cells into the microvascular system and fluid entering the interstitial tissue. (hindawi.com)
Drug7
  • 10. The drug delivery device of claim 5 wherein said body is impermeable to said pharmaceutically active agent. (google.de)
  • 12. The drug delivery device of claim 5 wherein said inner core comprises a semi-solid form, and said pharmaceutically active agent is disposed within said semi-solid form. (google.de)
  • 15. The drug delivery device of claim 1 wherein said pharmaceutically active agent is nepafenac. (google.de)
  • 17. The drug delivery device of claim 1 wherein said pharmaceutically active agent comprises eliprodil. (google.de)
  • The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. (springer.com)
  • 3. The resorbable drug delivery system of claim 1, wherein the binding agent is a hydrolyzed collagen or hydrolyzed elastin of a molecular weight of about 2500-4000. (google.com.au)
  • The anti-inflammatory activity of the methanol extract of the dried fruits shows that the presence of potential constituents present in this extract may provide assistance in the drug discovery process. (hindawi.com)
Peptic ulcer1
  • Peptic ulcer and non-steroidal anti-inflammatory agents. (bmj.com)
Derivatives1
  • A pilot study to examine the effects of an anti-inflammatory supplement on eicosanoid derivatives in patients with chronic kidney disease. (greenmedinfo.com)
Acetaminophen1
  • Tylenol (acetaminophen) is not an anti-inflammatory medicine and is not likely to help. (wikihow.com)
Pharmacology1
  • Comparative pharmacology of tromaril with other common non-steroidal anti-inflammatory agents. (bvsalud.org)
Clinical2
  • Check for active clinical trials using this agent. (cancer.gov)
  • Anti-inflammatory therapy may be beneficial for dry eye treatment which has been reported in a series of animal and clinical trials. (molvis.org)
Therapeutic3
  • 12. A method according to claim 1 wherein said agent is delivered into the posterior segment of the eye by initially administering the agent to the anterior segment of the eye in a form and dose that is sufficient to cause a therapeutic amount of the agent to distribute to the posterior segment. (google.com.au)
  • The objective of this study is to assess whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET-CT could be an early predictive method of therapeutic response to anti-PD-1 imm. (bioportfolio.com)
  • New therapeutic agents provide interesting new options for Patienten with difficult-to-treat gouty arthritis. (springer.com)
Receptors1
  • 3. Use according to either of the preceding claims, characterized in that the bradykinin antagonist is chosen from optionally modified, natural or synthetic peptides, natural or synthetic chemical molecules, antisense nucleic acids, ribozymes, anti-bradykinin antibodies, soluble bradykinin receptors, anti-bradykinin-receptor antibodies or bradykinin receptor antagonists. (freepatentsonline.com)
Effects8
  • Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes. (semanticscholar.org)
  • A number of studies report anti-inflammatory effects from Zeel. (isharonline.org)
  • Anti-arrhythmogenic and anti-inflammatory effects of troxerutin in ischemia/reperfusion injury of diabetic myocardium. (bioportfolio.com)
  • Anti-proliferation and anti-metastatic effects of sevoflurane on human osteosarcoma U2OS and Saos-2 cells. (bioportfolio.com)
  • To sum up, our results evidenced that sevoflurane exerted anti-proliferative and anti-metastatic effects on osteosarcoma cells by inactivating PI3K/AKT pathway. (bioportfolio.com)
  • Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with Capecitabine (Cap) and/or Irinoteca. (bioportfolio.com)
  • The biphasic effects of the oxLDL/βGPI/anti-βGPI complex on VSMC proliferation and apoptosis. (bioportfolio.com)
  • Resveratrol: Review on its discovery, pharmacokinetics and anti-leukemia effects. (bioportfolio.com)
Acute1
  • Experimental model of carrageenan-induced acute inflammation produces a range of inflammatory responses, due to the increase in the response to chemoattractants increasing PMN migration to the sites of inflammation [ 3 ]. (hindawi.com)
Responses1
  • The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during is. (bioportfolio.com)
Activity2
  • A murine IgG1 monoclonal anti-idiotype antibody, containing a variable antigen-binding region that functionally mimics the three-dimensional structure of a specific epitope on the ovarian cancer tumor-associated antigen CA-125, with potential antineoplastic activity. (cancer.gov)
  • However, its anti-metastatic activity rem. (bioportfolio.com)
Pharmaceutical3
  • 1. A topically applicable, physically and chemically stable pharmaceutical composition comprising an oil-in-water emulsion which contains: a. at least one steroidal anti-inflammatory agent, b. a pro-penetrating system which comprises at least one glycol and at least one additional pro-penetrating agent, c. at least one polymeric emulsifier other than an acrylate/C10-30 alkyl acrylate copolymer, formulated into a topically applicable, pharmaceutically acceptable vehicle therefor. (freepatentsonline.com)
  • 2. The pharmaceutical composition/oil-in-water emulsion as defined by claim 1, said at least one steroidal anti-inflammatory agent comprising hydrocortisone, an anthranoid, betamethasone valerate and/or clobetasol propionate. (freepatentsonline.com)
  • 4. The pharmaceutical composition/oil-in-water emulsion as defined by claim 1, said at least one pro-penetrating glycol being selected from the group consisting of a C1 to C6 alkylene or polyalkylene glycol and a glycol ether, and the at least one additional pro-penetrating agent being a glycol or a pro-penetrating agent selected from the family of fatty esters, fatty acids or fatty alcohols, or alcohols. (freepatentsonline.com)
Comprises4
  • A. delivering into the posterior segment of the eye a therapeutically effective amount of an agent that comprises urea or a urea derivative or mixtures thereof. (google.com.au)
  • 5. A method according to claim 3 wherein the agent delivered in Step A comprises 30 micrograms-7500 micrograms of urea per 50 micro liters to 100 microliters of solution. (google.com.au)
  • 10. A method according to claim 1 wherein the agent delivered in Step A comprises approximately 300 micrograms of urea per 50 microliters of solution. (google.com.au)
  • A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C2-16 α-hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed collagen or hydrolyzed elastin. (google.com.au)
Study4
  • A rapid spectrophotometric assay for prostaglandin synthetase: application to the study of non-steroidal antiinflammatory agents. (semanticscholar.org)
  • This study was designed to investigate anti-arrhythmic and anti-inflammatory po. (bioportfolio.com)
  • The present study was performed to elucidate the roles of serum anti-Sm antibodies in the pathogenesis of systemic lupus erythematosus (SLE). (bioportfolio.com)
  • This is an open label, single-arm, phase IB treatment study to determine the safety of administering anti-PD1 monoclonal antibodies with AV-MEL-1 and to get some suggestion of efficacy, in. (bioportfolio.com)
LISINOPRIL TABLETS, USPRx only
LISINOPRIL TABLETS, USPRx only (dailymed.nlm.nih.gov)
DailyMed - LISINOPRIL- lisinopril tablet
DailyMed - LISINOPRIL- lisinopril tablet (dailymed.nlm.nih.gov)
ENALAPRIL MALEATE TABLETS USP, 2.5 mg, 5 mg, 10 mg and 20 mg0026002700280029Rx only
ENALAPRIL MALEATE TABLETS USP, 2.5 mg, 5 mg, 10 mg and 20 mg0026002700280029Rx only (dailymed.nlm.nih.gov)
Diclofenac Sodium Topical : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Diclofenac Sodium Topical : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD (webmd.com)
Delzicol (Mesalamine Delayed-Release Capsules): Side Effects, Interactions, Warning, Dosage & Uses
Delzicol (Mesalamine Delayed-Release Capsules): Side Effects, Interactions, Warning, Dosage & Uses (rxlist.com)
Hyzaar (Losartan Potassium-Hydrochlorothiazide): Uses, Dosage, Side Effects, Interactions, Warning
Hyzaar (Losartan Potassium-Hydrochlorothiazide): Uses, Dosage, Side Effects, Interactions, Warning (rxlist.com)
Side Effects of Accupril (quinapril): Interactions & Warnings
Side Effects of Accupril (quinapril): Interactions & Warnings (medicinenet.com)
These highlights do not include all the information needed to use CANASA safely and effectively. See full prescribing...
These highlights do not include all the information needed to use CANASA safely and effectively. See full prescribing... (dailymed.nlm.nih.gov)
Perindopril - FDA prescribing information, side effects and uses
Perindopril - FDA prescribing information, side effects and uses (drugs.com)
Prinivil - FDA prescribing information, side effects and uses
Prinivil - FDA prescribing information, side effects and uses (drugs.com)
Teveten (Eprosartan Mesylate): Side Effects, Interactions, Warning, Dosage & Uses
Teveten (Eprosartan Mesylate): Side Effects, Interactions, Warning, Dosage & Uses (rxlist.com)
Eprosartan - FDA prescribing information, side effects and uses
Eprosartan - FDA prescribing information, side effects and uses (drugs.com)
Diovan (Valsartan): Uses, Dosage, Side Effects, Interactions, Warning
Diovan (Valsartan): Uses, Dosage, Side Effects, Interactions, Warning (rxlist.com)
Avalide (Irbesartan-Hydrochlorothiazide): Side Effects, Interactions, Warning, Dosage & Uses
Avalide (Irbesartan-Hydrochlorothiazide): Side Effects, Interactions, Warning, Dosage & Uses (rxlist.com)
Atacand (Candesartan Cilexetil): Uses, Dosage, Side Effects, Interactions, Warning
Atacand (Candesartan Cilexetil): Uses, Dosage, Side Effects, Interactions, Warning (rxlist.com)
These highlights do not include all the information needed to use LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE TABLETS safely and...
These highlights do not include all the information needed to use LOSARTAN POTASSIUM AND HYDROCHLOROTHIAZIDE TABLETS safely and... (dailymed.nlm.nih.gov)