Anti inflammatory agents non steroidal. Medical search

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)

Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)

A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Cholestane derivatives containing a fused lactone ring at the 16,17-position and a spiroglycosidic linkage at C-22. Members include sarsaponin, DIOSGENIN and yamogenin.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.

Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)

A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.

An alkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. (From The Merck Index, 11th ed)

A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.

Alkaloids, mainly tropanes, elaborated by plants of the family Solanaceae, including Atropa, Hyoscyamus, Mandragora, Nicotiana, Solanum, etc. Some act as cholinergic antagonists; most are very toxic; many are used medicinally.

An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.

A plant genus of the family ASCLEPIADACEAE. Members contain steroidal glycosides and cytotoxic phenanthroindolizidine N-oxide alkaloids.

The family of steroids from which the androgens are derived.

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.

Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

A plant genus of the family LILIACEAE. The common name of "dragon's blood" is also used for CROTON and Daemonorops (ARECACEAE).

A plant genus of the family SMILACACEAE. Members contain smiglasides (phenylpropanoid glycosides) and steroidal saponins. Commercially it is sometimes adulterated with HEMIDESMUS, which would affect experimental results.

A plant family of the order Euphorbiales, subclass Rosidae, class Magnoliopsida. Leaves are alternate, simple, and leathery. Fruits are one- or two-seeded capsules or drupes (stony-pitted fleshy fruits).

A plant genus of the family SOLANACEAE. Members contain SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for ATROPA BELLADONNA.

A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.

A genus of the plant family Liliaceae (sometimes classified as Alliaceae) in the order Liliales. Many produce pungent, often bacteriostatic and physiologically active compounds and are used as VEGETABLES; CONDIMENTS; and medicament, the latter in traditional medicine.

Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.

Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.

A plant genus of the family APOCYNACEAE. Members contain holarrhenine (a steroidal alkaloid) and TRICHOTHECENES.

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

A plant genus of the family LILIACEAE. Members contain anemarans (POLYSACCHARIDES), hinokiresinol, mangiferin (a xanthone), and timosaponin (a steroidal saponin).

Steroids in which one or more hydroxy groups have been substituted for hydrogen atoms either within the ring skeleton or on any of the side chains.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The characteristic three-dimensional shape of a molecule.

A plant genus in the family LILIACEAE (sometimes placed in Asparagaceae) that contains ECDYSTEROIDS and is an ingredient of Siotone. The shoots are used as a vegetable and the roots are used in FOLK MEDICINE.

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

A plant species of the genus SOLANUM, family SOLANACEAE that contains steroidal glycosides.

Subtotal or complete excision of the alveolar process of the maxilla or mandible. (Dorland, 28th ed)

Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.

A plant genus of the family SOLANACEAE. Members contain withanolides. Withania somnifera is the source of ashwagandha and aswal.

A genus known for fibers obtained from their leaves: sisal from A. sisalana, henequen from A. fourcroyoides and A. cantala, or Manila-Maguey fiber from A. cantala. Some species provide a sap that is fermented to an intoxicating drink, called pulque in Mexico. Some contain agavesides.

A plant genus of the family LILIACEAE. Members contain steroidal glycosides and provide an ingredient of shengmaisan (DRUGS, CHINESE HERBAL).

8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.

A plant genus of the family LILIACEAE that is a short plant with a distinct whorl of 3 broad leaves.

A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.

A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.

A class of organic compounds known as STEROLS or STEROIDS derived from plants.

Substances that are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.

A plant genus of the family LILIACEAE that contains CARDIAC GLYCOSIDES.

Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.

A plant genus of the family ASCLEPIADACEAE. Members contain pregnane glycosides (marsdekoiside & marstomentosides, maryal) and hainaneosides (SAPONINS).

A plant family of the order Solanales, subclass Asteridae. Among the most important are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.

A plant family of the order Liliales, subclass Liliidae, class Liliopsida. Members of the family have narrow, lance-shaped, sometimes fleshy or toothed leaves that are clustered at the base of each plant. Most species have large flower clusters containing many flowers. The fruit is a capsule or berry.

A plant genus of the family LILIACEAE. Members of this genus produce imperialine, a steroidal alkaloid which acts at muscarinic receptors.

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

Unsaturated derivatives of PREGNANES.

A plant genus of the family LILIACEAE with roots that contain VERATRUM ALKALOIDS used as emetics, parasiticides, antihypertensives. It is the main ingredient of Boicil.

A plant genus of the family LILIACEAE. Members contain steroidal saponins.

An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.

A mixture of alpha-chaconine and alpha-solanine, found in SOLANACEAE plants.

Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)

Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension. (1/7426)

OBJECTIVE: To investigate the usefulness of hydroxychloroquine (HCQ) dose-loading to increase the percentage of responders or rate of response in treating rheumatoid arthritis (RA). METHODS: Two hundred twelve patients with early RA (mean duration 1.5 years) were enrolled in a 24-week trial. Patients were stabilized with 1,000 mg naproxen/day and then began a 6-week, double-blind trial comparing treatment with HCQ at 400 mg/day (n = 71), 800 mg/day (n = 71), and 1,200 mg/day (n = 66), followed by 18 weeks of open-label HCQ treatment at 400 mg/day. RESULTS: All patients had mild, active disease at the time of initiation of HCQ treatment (31-43% rheumatoid factor positive; no previous disease-modifying antirheumatic drugs; mean swollen joint count 8.6-10.4). Based on the Paulus criteria, response during the 6-week double-blind portion of the study was 47.97%, 57.7%, and 63.6% in the 400 mg/day, 800 mg/day, and 1,200 mg/day groups, respectively (P = 0.052). Discontinuations for adverse events were dose related (3 in the 400 mg/day group, 5 in the 800 mg/day group, 6 in the 1,200 mg/day group). Most involved the gastrointestinal (GI) system, with the background naproxen treatment possibly contributing. Ocular abnormalities occurred in 17 of 212 patients (8%) but were not dose related. CONCLUSION: Dose-loading with HCQ increased the degree of response at 6 weeks in this group of patients with early, predominantly seronegative RA. Adverse GI events were dose related, while adverse ocular events were not. (+info)

Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. (2/7426)

Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorigenesis. We have examined apoptosis induction by non-steroidal anti-inflammatory drugs (NSAIDs) in human gastric (AGS) cancer cells and the role of protein kinase C (PKC) and apoptosis-related oncogenes. After treatment with aspirin or indomethacin, cell growth was quantified by MTT assay, and apoptosis was determined by acridine orange staining, DNA fragmentation and flow cytometry. The mRNA and protein of p53, p21waf1/cip1 and c-myc was detected by Northern and Western blotting respectively. The influence of PKC on indomethacin-induced apoptosis was determined by co-incubation of 12-O-tetradecanoylphorbol 13-acetate (TPA). The role of c-myc was determined using its antisense oligonucleotides. The results showed that both aspirin and indomethacin inhibited cell growth and induced apoptosis of AGS cells in a dose- and time-dependent manner, without altering the cell cycle. Indomethacin increased c-myc mRNA and protein, whereas p53 and p21wafl/cip1 were unchanged. Down-regulation of c-myc by its antisense oligonucleotides reduced apoptosis induction by indomethacin. TPA could inhibit indomethacin-induced apoptosis and accumulate cells in G2/M. Overexpression of c-myc was inhibited by TPA and p21waf1/cip1 mRNA increased. In conclusion, NSAIDs induce apoptosis in gastric cancer cells which may be mediated by up-regulation of c-myc proto-oncogene. PKC activation can abrogate the effects of NSAIDs by decreasing c-myc expression. (+info)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (3/7426)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted. (+info)

Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. (4/7426)

LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7.3 x 10(-6) mole fraction, which approached the stiochiometric limit of this assay. The true potency of LY315920 was defined using a deoxycholate/phosphatidylcholine assay with a mole fraction of 1.5 x 10(-6). LY315920 was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase. Human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells was inhibited by LY315920 with an IC50 of 0.79 microM. The release of TXA2 from these cells by N-formyl-methionyl-leucyl-phenylalanine or arachidonic acid was not inhibited. The i.v. administration of LY315920, 5 min before harvesting the bronchoalveolar lavage cells, resulted in the inhibition of sPLA2-induced production of TXA2 with an ED50 of 16.1 mg/kg. Challenge of guinea pig lung pleural strips with sPLA2 produced contractile responses that were suppressed in a concentration-dependent manner by LY315920 with an apparent KB of 83 +/- 14 nM. Contractile responses induced by arachidonic acid were not altered. Intravenous or oral administration of LY315920 to transgenic mice expressing the human sPLA2 protein inhibited serum sPLA2 activity in a dose-related manner over a 4-h time course. LY315920 is a potent and selective sPLA2 inhibitor and represents a new class of anti-inflammatory agent designated SPI. This agent is currently undergoing clinical evaluation and should help to define the role of sPLA2 in various inflammatory disease states. (+info)

Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. (5/7426)

The marked analgesic efficacy of ketorolac in humans, relative to other nonsteroidal anti-inflammatory drugs (NSAIDs), has lead to speculation as to whether additional non-NSAID mechanism(s) contribute to its analgesic actions. To evaluate this possibility, we characterized (R,S)-ketorolac's pharmacological properties in vivo and in vitro using the nonselective cyclooxygenase (COX) inhibitors [indomethacin (INDO) and diclofenac sodium (DS)] as well as the selective COX-2 inhibitor, celecoxib, as references. The potency of racemic (R,S)-ketorolac was similar in tests of acetic acid-induced writhing, carrageenan-induced paw hyperalgesia, and carrageenan-induced edema formation in rats; ID50 values = 0.24, 0. 29, and 0.08 mg/kg, respectively. (R,S)-ketorolac's actions were stereospecific, with (S)-ketorolac possessing the biological activity of the racemate in the above tests. The analgesic potencies for (R,S)-, (S)-, and (R)-ketorolac, INDO, and DS were highly correlated with their anti-inflammatory potencies, suggesting a common mechanism. (R,S)-ketorolac was significantly more potent than INDO or DS in vivo. Neither difference in relative potency of COX inhibition for (R,S)-ketorolac over INDO and DS nor activity of (S)-ketorolac at a number of other enzymes, channels, or receptors could account for the differences in observed potency. The distribution coefficient for (R,S)-ketorolac was approximately 30-fold less than for DS or INDO, indicating that (R,S)-ketorolac is much less lipophilic than these NSAIDs. Therefore, the physicochemical and pharmacokinetics properties of (R,S)-ketorolac may optimize the concentrations of (S)-ketorolac at its biological target(s), resulting in greater efficacy and potency in vivo. (+info)

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (6/7426)

1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent scratching of the injected site with the forepaws and hindpaws. 2. Up to 100 microg of sodium deoxycholic acid induced no significant increase in vascular permeability at the injection site as assessed by a dye leakage method. 3. Bradykinin (BK) B2 receptor antagonists, FR173657 and Hoe140, significantly decreased the frequency of scratching induced by sodium deoxycholic acid. 4. Treatment with aprotinin to inhibit tissue kallikrein reduced the scratching behaviour induced by sodium deoxycholic acid, whereas treatment with soybean trypsin inhibitor to inhibit plasma kallikrein did not. 5. Although injection of kininase II inhibitor, lisinopril together with sodium deoxycholic acid did not alter the scratching behaviour, phosphoramidon, a neutral endopeptidase inhibitor, significantly increased the frequency of scratching. 6. Homogenates of the skin excised from the backs of mice were subjected to gel-filtration column chromatography followed by an assay of kinin release by trypsin from each fraction separated. Less kinin release from the fractions containing kininogen of low molecular weight was observed in the skin injected with sodium deoxycholic acid than in normal skin. 7. The frequency of scratching after the injection of sodium deoxycholic acid in plasma kininogen-deficient Brown Norway Katholiek rats was significantly lower than that in normal rats of the same strain, Brown Norway Kitasato rats. 8. These results indicate that BK released from low-molecular-weight kininogen by tissue kallikrein, but not from high-molecular-weight kininogen by plasma kallikrein, may be involved in the scratching behaviour induced by the injection of sodium deoxycholic acid in the rodent. (+info)

The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. (7/7426)

To determine whether declining semen quality associated with health problems may be due to certain antibiotic or anti-inflammatory treatments, semen was collected 3 times per week for up to 42 d from 6 normal bulls after treatment with oxytetracycline, tilmicosin, dihydrostreptomycin, or phenylbutazone. No adverse effects on semen quality were observed. (+info)

Pseudogout attack associated with chronic thyroiditis and Sjogren's syndrome. (8/7426)

A 66-year-old woman, diagnosed with chronic thyroiditis at age 63, presented with anorexia and fatigue. Therapy for the chronic thyroiditis consisted of levothyroxine sodium (100 microg/day). Her symptoms were attributed to the insufficient supply of levothyroxine sodium. Following a dosage increase to 150 microg/day, she suffered from an acute attack of pseudogout. Clinical features were complicated by Sjogren's syndrome, which appeared after treatment onset. Pseudogout was effectively treated by colchicine after administration of diclofenac sodium failed to alleviate the symptoms. Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjogren's syndrome has not been previously reported. (+info)

... anti-epileptic and non-steroidal anti-inflammatory drugs; X-ray contrast agents; polycyclic musk fragrances; and ingredients of ... X-ray contrast agents, and ingredients of personal care products, can be broken down in a non-toxic way. Mycoremediation is a ...

https://en.wikipedia.org/wiki/Mycoremediation

Hirohata M, Ono K, Naiki H, Yamada M (December 2005). "Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects ... It increases cerebral blood flow and is an anti-inflammatory agent, enhancing activity at the neuronal synapses in the brain. ... Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer's and Parkinson's diseases. The ... Etminan M, Gill S, Samii A (July 2003). "Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: ...

https://en.wikipedia.org/wiki/Prevention_of_dementia

... is a nonsteroidal anti-inflammatory drug (NSAID) used as an analgesic, antipyretic, and anti-inflammatory agent. It is a ... Hirate K, Uchida A, Ogawa Y, Arai T, Yoda K (April 2006). "Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits ...

https://en.wikipedia.org/wiki/Zaltoprofen

Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils". Organic ... Similar to classical non-steroidal anti-inflammatory drugs, it is a non-selective inhibitor of cyclooxygenase (COX). 50 g (more ... a natural anti-inflammatory agent in extra virgin olive oils". Chem Senses. 34 (4): 333-9. doi:10.1093/chemse/bjp006. PMC ... "Against this background, the in vivo anti-inflammatory effects of dietary oleocanthal cannot be as relevant as hypothesized by ...

https://en.wikipedia.org/wiki/Oleocanthal

... on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese Journal of Pharmacology. ... Tanaka, H; Shuto, K; Marumo, H (1982). "Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, ... 35-. ISBN 978-0-8155-1856-3. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ... and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor ...

https://en.wikipedia.org/wiki/Aceglutamide

Done Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular oedema PMID 25686158 https://doi.org/10.1002/ ... Done Anti-tumour necrosis factor biological therapies for the treatment of uveitic macular oedema (UMO) for non-infectious ... Done Anti-vascular endothelial growth factor combined with intravitreal steroids for diabetic macular oedema PMID 29669176 ... Done Anti-vascular endothelial growth factor for choroidal neovascularisation in people with pathological myopia PMID 27977064 ...

https://en.wikipedia.org/wiki/Wikipedia:WikiProject_Medicine/Cochrane/Cochrane_Review_List/Musculoskeletal,_Oral,_Skin_and_Sensory

... other non-steroidal anti-inflammatory agents (NSAID) in humans.[34][22] Synthetic BLT2 agonists may be useful for speeding the ... Opposition between the pro-inflammatory LTB4/BLT1 and anti-inflammatory actions of the 12-HHT/BLT2 axes occurs in another ... exerting an anti-inflammatory activity". Experimental & Molecular Medicine. 44 (6): 378-86. doi:10.3858/emm.2012.44.6.043. PMC ... and other agents.[23] BLT2 may ultimately prove to have binding specificity for a similarly broad range of agents. ...

https://en.wikipedia.org/wiki/12-Hydroxyheptadecatrienoic_acid

Salicylic acid is a non-steroidal anti-inflammatory drug (NSAID) almost identical to aspirin. In fact, aspirin's mechanism of ... It is often incorrectly thought to be a drying agent; however, this is not true. Salicylic acid works as a keratolytic, ... "Anti-Inflammatory Activity of Aspirin - It's All About Salicylic Acid". American Chemical Society. Archived from the original ... comedolytic, and bacteriostatic agent, causing the cells of the epidermis to shed more readily, opening clogged pores and ...

https://en.wikipedia.org/wiki/Carmex

More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... "Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis". British Medical Journal (Clinical ... Anti-inflammatory (or antiinflammatory) is the property of a substance or treatment that reduces inflammation or swelling. Anti ... Nonsteroidal anti-inflammatory drugsEdit. Nonsteroidal anti-inflammatory drugs (NSAIDs) alleviate pain by counteracting the ...

https://en.m.wikipedia.org/wiki/Anti-inflammatory

Nonsteroidal anti-inflammatory agents/analgesics (NSAIAs), Nonsteroidal anti-inflammatory medicines (NSAIMs). Use. Pain, fever ... 2012). "Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease". Cochrane ... "Medications - non-steroidal anti-inflammatory drugs". Retrieved 2 February 2018.. *^ Lee A, Cooper MG, Craig JC, Knight JF, ... February 2015). "Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer's disease: a systematic review and meta- ...

https://en.m.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug

These are the non-steroidal anti-inflammatory drugs (NSAIDS). Aspirin irreversibly disrupts platelet function by inhibiting ... Platelets release platelet-derived growth factor (PDGF), a potent chemotactic agent; and TGF beta, which stimulates the ... Anti-inflammatory drugs[edit]. Some drugs used to treat inflammation have the unwanted side effect of suppressing normal ... Berridge, Michael J. (1 October 2014). "Module 11: Cell Stress, Inflammatory Responses and Cell Death". Cell Signalling Biology ...

https://en.wikipedia.org/wiki/Thrombocytopathy

The free radical induction theory, discussed below, proposes that 5-ASA is serving not just as an anti-inflammatory agent, but ... 5-ASA is related to the systemic non-steroidal anti-inflammatory drugs (NSAIDs), such as Aspirin and Ibuprofen. ... Oral anti-inflammatory drugs require four to six weeks to work. Once remission is induced, maintenance levels can be used: ... The anti-inflammatory action in all these drugs is produced by 5-aminosalicylic acid (5-ASA), the active ingredient in ...

https://en.wikipedia.org/wiki/Management_of_ulcerative_colitis

The details of parasite immune modulation are not yet known, but may include secretion of anti-inflammatory agents or ... Steroidal or NSAID treatment limits inflammatory symptoms of many diseases. IVIG is used for CIDP and GBS. Specific ... Treatments for autoimmune disease have traditionally been immunosuppressive, anti-inflammatory, or palliative.[8] Managing ... 2002) injected an anti-MHC Class II antibody into mice expressing a single type of MHC Class II molecule (H-2b) to temporarily ...

https://en.wikipedia.org/wiki/Autoimmune

These are the non-steroidal anti-inflammatory drugs (NSAIDS). Aspirin irreversibly disrupts platelet function by inhibiting ... Platelets release platelet-derived growth factor (PDGF), a potent chemotactic agent; and TGF beta, which stimulates the ... Anti-inflammatory drugsEdit. Some drugs used to treat inflammation have the unwanted side effect of suppressing normal platelet ... Simplistically, bound and activated platelets degranulate to release platelet chemotactic agents to attract more platelets to ...

https://en.m.wikipedia.org/wiki/Platelet

Jaturapatporn D, Isaac MG, McCleery J, Tabet N (February 2012). "Aspirin, steroidal and non-steroidal anti-inflammatory drugs ... A Nonsteroid Antiinflammatory Agent". Pharmaceutical Chemistry Journal. 11 (12): 1706-1711. doi:10.1007/BF00778304.. ... "Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer's disease: a systematic review and meta-analysis of ... "Anti-inflammatory drugs and risk of Alzheimer's disease: an updated systematic review and meta-analysis". Journal of ...

https://en.m.wikipedia.org/wiki/Mefenamic_acid

It is used as a topical and ophthalmic anti-inflammatory drug in the treatment of skin and eye conditions, respectively. 11β- ... Endrisone (INN) (brand name Aldrisone), or endrysone (USAN), is a synthetic, steroidal glucocorticoid which is or has been ... 486-. ISBN 978-1-4757-2085-3. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties ...

https://en.wikipedia.org/wiki/Endrisone

... nephrotoxins like radiologic contrast and non-steroidal anti-inflammatory drugs), antihypertensives, diet and weight ... An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D ... Auto-immune and inflammatory kidney disease, such as vasculitis or transplant rejection, may be treated with immunosuppression ... Commonly used agents are prednisone, mycophenolate, cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and ...

https://en.wikipedia.org/wiki/Nephrology

This was shown when the anti-hyperalgesic action was reduced when administered in α2 and α3 mice in inflammatory pain and in ... In a rat brain slice preparation, the synthetic steroidal anesthetic alphaxalone (5α-pregnan-3α-ol-11,20 dione) enhanced both ... Sedative actions of benzodiazepines limit their usefulness as analgesic agents and they are therefore generally not considered ... Additionally, studies in α5 mice showed that the spinal α5-containing GABAA receptor has a minor role in inflammatory pain. An ...

https://en.wikipedia.org/wiki/GABAA_receptor_positive_allosteric_modulator

These include β2-agonists, dopamine, insulin, allopurinol, and non-steroidal anti-inflammatory drugs (NSAIDs), such as ... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ... These agents are less likely to produce early warning signs (phosgene in low concentrations has a pleasant odor), are more ...

https://en.wikipedia.org/wiki/Acute_inhalation_injury

Some drugs, especially non steroidal anti-inflammatory drugs, can trigger pseudoporphyria in the presence of ultraviolet light ... Agents associated with pseudoporphyria are as follows: Propionic acid derivatives (NSAIDs) - naproxen, diflunisal, ketoprofen, ... reports suggest that a connective tissue disorder may be a predisposing factor in patients using nonsteroidal anti-inflammatory ... As recognition of pseudoporphyria increases and the number of new medications expands, the list of etiologic agents associated ...

https://en.wikipedia.org/wiki/Pseudoporphyria

Often this is first attempted with non-steroidal anti-inflammatory medications, but the long-term use of Non-steroidal anti- ... Targeted anatomic administration of one of these anti-TNF agents, etanercept, a patented treatment method, has been suggested ... The targeted anatomic use of a potent anti-inflammatory anti-TNF therapeutics is being investigated. The number of spinal ... non-steroidal anti-inflammatory (NSAID) medications, membrane stabilizers, antidepressants, spinal cord stimulation, and ...

https://en.wikipedia.org/wiki/Failed_back_syndrome

Their medicinal value is due to their expectorant, and corticoid and anti-inflammatory effects. Steroid saponins, for example, ... Here the aglycone part is a steroidal nucleus. These glycosides are found in the plant genera Digitalis, Scilla, and ... Saponins are also natural ruminal antiprotozoal agents that are potential to improve ruminal microbial fermentation reducing ... and antiinflammatory effects. These glycosides contain an aglycone group that is a derivative of anthraquinone. They have a ...

https://en.wikipedia.org/wiki/Glycoside

... anti-inflammatory agents MeSH D27.505.954.158.030 - anti-inflammatory agents, non-steroidal MeSH D27.505.954.158.030.500 - ... anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122.085 - anti-bacterial agents MeSH D27.505 ... antirheumatic agents MeSH D27.505.954.329.030 - anti-inflammatory agents, non-steroidal MeSH D27.505.954.329.337 - gout ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)

... non-steroidal-anti-inflammatory) regimens have only transient effects on platelet COX-1 and have been found to be associated " ... Ratti, S; Quarato, P; Casagrande, C; Fumagalli, R; Corsini, A (1998). "Picotamide, an antithromboxane agent, inhibits the ... "Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant ... Cavar I (2011). "Anti-thromboxane B2 antibodies protect against acetaminophen-induced liver injury in mice". Journal of ...

https://en.wikipedia.org/wiki/Thromboxane_inhibitors

Some of the most commonly used nephrotoxic medications are non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.[43 ... Glycemic control is maintained mainly with insulin in patients with Type 1 DM and with hypoglycemic agents and/or insulin in ... it is recommended that only one agent is used in patients with DM who have hypertension or any signs of microalbuminuria or ... Although RAAS blockade using more than one agent may further reduce proteinuria, the risk of adverse events (such as ...

https://en.wikipedia.org/wiki/Diabetic_nephropathy

Non steroidal Anti Inflammatory Drugs They inhibit prostaglandin E2 formation (PGE2) that is produced by neutrophils, ... Enamel Matrix Protein These agents not only help improve wound healing but also stimulate regeneration of the lost bone, ... Currently Emdogain is the only approved host modulatory agent of this type. Growth Factors Bone Morphogenic Proteins Michael G ...

https://en.wikipedia.org/wiki/Host_modulatory_therapy

"Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a ... "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents". Nature. 384 (6610): 644-8. doi: ... FitzGerald GA (March 2002). "Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: ... it is not anti-inflammatory. Daniel L. Simmons' group suggested this was because of the presence of a variant of COX-1, which ...

https://en.wikipedia.org/wiki/COX-3

FDA Strengthens Warning of Heart Attack and Stroke Risk for Non-Steroidal Anti-Inflammatory Drugs. FDA. 2015-07-09 [2015-07-09] ... EF Reynolds (編). Aspirin and similar analgesic and anti-inflammatory agents. Martindale: The Extra Pharmacopoeia 28th: 234-82. ... Pharmacokinetic Solubility And Dissolution Profile of Non-Steroidal Anti-Inflammatory Drugs 2 (3). 2011.. ... Nonsteroidal anti-inflammatory drug-induced reactions and desensitization. J Asthma. 2004, 41 (4): 375-84. PMID 15281324. doi: ...

https://zh.wikipedia.org/zh-hant/阿斯匹林

Inhibits diverse inflammatory responses in animal models; structural model for developing anti-inflammatory agents[10][57][58] ... Inhibition of COX-1 and/or the inducible COX-2 isoforms, is the hallmark of NSAIDs (non-steroidal anti-inflammatory drugs), ... are less inflammatory, or inactive, or even anti-inflammatory and pro-resolving. ... PGA1, PGA2, PGJ2, Δ12-PGJ2, and 15-deox-Δ12,14-PGJ2 exhibit a wide range of anti-inflammatory and inflammation-resolving ...

https://en.wikipedia.org/wiki/Eicosanoid

Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and ... was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of ... associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. ...

http://gut.bmj.com/content/27/8/929

The emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology. ... Emerging roles of topical non-steroidal anti-inflammatory agents in ophthalmology. Free ...

http://bjo.bmj.com/content/80/12/1117.1

Contributing role of non-steroidal anti-inflammatory agents] ... Contributing role of non-steroidal anti-inflammatory agents] ...

https://pubmed.ncbi.nlm.nih.gov/8146835/

... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ... deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in ...

http://jpet.aspetjournals.org/content/217/3/776

... while they preserve or augment their anti-inflammatory activity, thus addressing significant risk factors for atherogenesis. ... Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), α-lipoic acid and indole-3-acetic acid with thiomorpholine were ... Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti- ... of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory ...

https://www.semanticscholar.org/paper/Amides-of-non-steroidal-anti-inflammatory-drugs-can-Theodosis-Nobelos-Kourti/12b13103450b8d4c18fd313b6dc1bb082e685cbe

... application to the study of non-steroidal antiinflammatory agents. by Clyde A Takeguchi et al. ... 2,6-Di-tert-butyl-4-(2′-thenoyl)phenol(R-830): A novel nonsteroidal anti-inflammatory agent with antioxidant properties. * ... application to the study of non-steroidal antiinflammatory agents.. *. Clyde A Takeguchi, Charles J. Sih ... Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes.. *Christian ...

https://www.semanticscholar.org/paper/A-rapid-spectrophotometric-assay-for-prostaglandin-Takeguchi-Sih/dc15017fdc845c01ad8e0521ac65fe4c6446e182

Combination Of Alpha-2 Adrenergic Receptor Agonist And Non-steroidal Anti-inflammatory Agent For Treating Or Preventing An ...

https://www.lens.org/lens/patent/EP_2329849_A1/family

OBJECTIVE: To assess the effectiveness of conservative therapy in carpal tunnel syndrome. DATA SOURCES: A computer-aided search of MEDLINE and the Cochrane Collaboration was conducted for randomized controlled trials (RCTs) from January 1985 to May 2006. REVIEW METHODS: RCTs were included if: (1) the patients, with clinically and electrophysiologically confirmed carpal tunnel syndrome, had not previously undergone surgical release, (2) the efficacy of one or more conservative treatment options was evaluated, (3) the study was designed as a randomized controlled trial ...

http://isharonline.org/tags/anti-inflammatory-agents-non-steroidal

Anti. -. Inflammatory. Agents. , Non. -. Steroidal. */adverse effects Anti. -. Inflammatory. Agents. , Non. -. Steroidal. */ ... Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /adverse effects ; Anti. -. Inflammatory. Agents. , Non. -. Steroidal. / ... Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /chemistry ; Anti. -. Inflammatory. Agents. , Non. -. Steroidal. / ... Anti. -. Inflammatory. Agents. /*adverse effects Anti. -. Inflammatory. Agents. , Non. -. Steroidal. /*adverse effects ...

https://katalog.ue.wroc.pl/eds/search?q=%22Anti-Inflammatory+Agents%2C+Non-Steroidal%22&index=4

... and inflammatory processes all of which represent important features in the pathology of acne vulgaris. ...

http://pharmacycode.com/Adapalene.html

... has been used as both an antimalarial and an anti-inflammatory agent for more than 40 years. Amodiaquine is at least as ...

http://pharmacycode.com/Amodiaquine.html

Non-steroidal Anti-inflammatory Agents: In some patients with comprised renal function who are being treated with non-steroidal ... Other Agents: Lisinopril has been used concomitantly with nitrates and/or digoxin without evidence of clinically significant ... Agents Increasing Serum Potassium: Lisinopril attenuates potassium loss caused by thiazide-type diuretics. Use of lisinopril ... anti-inflammatory drugs, the co-administration of lisinopril may result in further deterioration of renal function. These ...

https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=26558

Non-Steroidal Anti-Inflammatory Agents In a study in 36 patients with mild to moderate hypertension where the antihypertensive ... 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) 7.4 Dual Blockade ... 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who ... Hypoglycemia: Tell diabetic patients treated with oral antidiabetic agents or insulin starting an ACE inhibitor to monitor for ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8ad5c56-0368-fbb5-290d-c32d19b8ab06

More Resources for Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical. *Find Lowest Prices on ... How to use Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical. Read the Medication Guide provided by ... List Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents (NSAID), Topical side effects by likelihood and severity. ... What should I know regarding pregnancy, nursing and administering Diclofenac Sodium Gel Non-Steroidal Anti-Inflammatory Agents ...

https://www.webmd.com/drugs/2/drug-22221-4289/diclofenac-sodium-topical/diclofenac-3-topical/details

Nephrotoxic Agents, Including Non-Steroidal Anti-Inflammatory Drugs. The concurrent use of mesalamine with known nephrotoxic ... agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of renal reactions [see WARNINGS AND ... releasing mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon. Mesalamine (also ... as active inflammatory bowel disease is also associated with adverse pregnancy outcomes. ...

https://www.rxlist.com/asacol-hd-drug.htm

Nephrotoxic Agents, Including Non-Steroidal Anti-Inflammatory Drugs. The concurrent use of mesalamine with known nephrotoxic ... agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of renal reactions [see WARNINGS AND ... which dissolves at pH 7 or greater and releases mesalamine in the terminal ileum and beyond for topical anti-inflammatory ... as active inflammatory bowel disease is also associated with adverse pregnancy outcomes. ...

https://www.rxlist.com/delzicol-drug.htm

Anti-Inflammatory Agents, Non-Steroidal. LinkOut - more resources. Full Text Sources. *Wiley ... Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study.. Ofori B1 ... Many women take non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain ...

https://www.ncbi.nlm.nih.gov/pubmed/16929547?dopt=Abstract

Anti-Inflammatory Agents. Anti-Inflammatory Agents, Non-Steroidal. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents ... and Chronic Non-steroidal Anti-inflammatory Drug (NSAID) Use. The safety and scientific validity of this study is the ... and for gastroprotection for patients on chronic non-steroidal anti-inflammatory drugs (NSAIDs) at increased risk for upper GI ... nonsteroidal anti-inflammatory drugs. peptic ulcer. Diagnosed GERD. Atypical GERD symptoms. chronic NSAID therapy. Risk for ...

https://clinicaltrials.gov/ct2/show/NCT00691171

Anti-Inflammatory Agents. Lansoprazole. Dexlansoprazole. Anti-Inflammatory Agents, Non-Steroidal. Anti-Ulcer Agents. ... Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Antirheumatic Agents. ... in patients with a history of gastric or duodenal ulcer who require long-term therapy of non-steroidal anti-Inflammatory drug ( ... for the Prevention of Recurrent Gastric or Duodenal Ulcers During Long-term Therapy of Non-steroidal Anti-inflammatory Drug ( ...

https://clinicaltrials.gov/ct2/show/NCT01452750?recr=Open&cond=%22Duodenal+Ulcer%22&rank=8

Anti-Inflammatory Agents, Non-Steroidal. Anti-Inflammatory Agents. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents ... Active Comparator: Non-steroidal Anti-inflammatory Drug (NSAIDs) Participants will receive fixed dose combination of tramadol ... A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory ... plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants ...

https://www.clinicaltrials.gov/ct2/show/NCT00635349?term=TRAMADOL&

Non-steroidal anti-inflammatory agents to induce regression and prevent the progression of cervical intraepithelial neoplasia. ... Grabosch, S. M., Shariff, O. M., Wulff, J. L., & Helm, C. W. (2014, April 9). Non-steroidal anti-inflammatory agents to induce ... Objectives: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including ...

https://www.mendeley.com/catalogue/f24423ef-483d-3ad8-97f0-4cc8321bb2e4/

Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors. Telmisartan. Non-Steroidal Anti- ... Administration of a non-steroidal anti-inflammatory agent, including a selective COX‑2 inhibitor, can reduce the diuretic, ... Therefore, when MICARDIS HCT and non-steroidal anti-inflammatory agents including selective COX‑2 inhibitors are used ... aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). *potassium supplements or a salt substitute containing ...

https://www.drugs.com/pro/micardis-hct.html

Results of search for su:{Anti-inflammatory agents, Non-steroidal} No results found! No results found for that in WHO HQ ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BAnti-inflammatory%20agents,%20Non-steroidal%7D

Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenas e-2 Inhibitors (COX-2 Inhibitors ). *In patients who ... There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen, indomethacin, ... Closely monitor blood pressure, renal function and electrolytes in patients on Zestril and other agents that affect the RAS. ... Concomitant administration of Zestril and antidiabetic medicines (insulins, oral hypoglycemic agents) may cause an increased ...

https://www.medicinenet.com/side_effects_of_lisinopril/side-effects.htm

Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors). In patients who are ... Closely monitor blood pressure, renal function and electrolytes in patients on Perindopril erbumine and other agents that ... Formal interaction studies of Perindopril erbumine have not been carried out with antihypertensive agents other than thiazides ... In patients undergoing surgery or during anesthesia with agents that produce hypotension, Perindopril erbumine may block ...

https://www.drugs.com/pro/perindopril.html

This topic contains 105 study abstracts on Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) indicating it may contribute to ... Anti-Inflammatory Agents. Additional Keywords : Natural Substances Versus Drugs. Problem Substances : Non-Steroidal Anti- ... 21 Adverse Pharmacological Actions Researched for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Name. AC. CK. Focus. ... 4 Abstracts with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) & Rheumatoid Arthritis Research. [x] Remove Focus on Rheumatoid ...

http://www.greenmedinfo.com/toxic-ingredient/non-steroidal-anti-inflammatory-drugs-nsaids?ed=4226

https://en.wikipedia.org/wiki/Mycoremediation

To evaluate this traditional medicinal effect, we investigated the anti-chronic infl … ... Keywords: Anti-chronic inflammatory activity; Cellular senescence; Homoisoflavone; Ophiopogon japonicus; SASP; Steroidal ... Anti-Inflammatory Agents / pharmacology * Anti-Inflammatory Agents / therapeutic use* * Cellular Senescence / drug effects* ... Anti-inflammatory activities of Ophiopogonis Radix on hydrogen peroxide-induced cellular senescence of normal human dermal ...

https://pubmed.ncbi.nlm.nih.gov/29961188/

Jones P, Lamdin R, Dalziel SR Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft ... The best drug treatment for such injuries is not certain, although non-steroidal anti-inflammatory drugs (NSAIDs) are often ... The applicability of findings from these studies is in question because the dextropropoxyphene combination analgesic agents ...

https://www.painpluscpn.ca/Home/Article/98529

Many women take non-steroidal anti-inflammatory drugs (NSAIDs) during pregnancy but the risks for the infant remain controversial. (nih.gov)
The purpose of the study is to examine the impact of augmented, high-quality physician-coordinated care executed via an electronic health record (EHR)-based intervention on quality of care for gastroesophageal reflux disease (GERD) and for gastroprotection for patients on chronic non-steroidal anti-inflammatory drugs (NSAIDs) at increased risk for upper GI tract ulcers and ulcer related complications. (clinicaltrials.gov)
The purpose of this study is to compare the effectiveness of tramadol hydrochloride 37.5 milligram (mg) plus acetaminophen 325 mg maintenance with that of non-steroidal anti-inflammatory drugs (NSAIDs) maintenance in participants with knee osteoarthritis (a progressive and degenerative joint disease, in which the joints become painful and stiff) whose pain was relieved after the add-on treatment of tramadol hydrochloride to NSAIDs. (clinicaltrials.gov)
Objectives: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, to induce regression and prevent the progression of cervical intraepithelial neoplasia CIN. (mendeley.com)
There have been reports that aspirin and other nonsteroidal anti-inflammatory drugs ( NSAIDS ) such as ibuprofen , indomethacin , and naproxen may reduce the effects of ACE inhibitors. (medicinenet.com)
The best drug treatment for such injuries is not certain, although non-steroidal anti-inflammatory drugs (NSAIDs) are often recommended. (painpluscpn.ca)
The present study was designed to investigate human gastric blood flow during administration of non-steroidal anti-inflammatory drugs (NSAIDs) by harmonic flash echo imaging. (biomedsearch.com)
The present invention relates generally to pharmaceutical preparations and medical treatment methods, and more particularly agents (i.e, urea and urea derivatives, nonsteroidal anti-inflammatory drugs (NSAIDS) and anti-metabolite drugs) used alone or in combinations with each other (or with other agents) to treat or prevent certain disorders of the eye. (google.com.au)
Nonsteroidal anti-inflammatory drugs (NSAIDs), both nonselective and cyclooxygenase-2-specific inhibitors, are commonly used medications for the relief of acute and chronic pain associated with a wide range of medical conditions. (nih.gov)
We also reviewed the literature to assess the risks and effectiveness of nonsteroidal anti-inflammatory drugs (NSAIDs), which are often used as the "conventional" first-line treatment for similar musculoskeletal conditions. (chiro.org)
Background Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of heart failure. (bmj.com)
Introduction: Currently, the diagnosis of nonsteroidal antiinflammatory drugs (NSAIDs) hypersensivitity is based on patients´ clinical history and drug provocation tests, which are done in selected cases. (usp.br)
Background: Transdermal route of delivery of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) has several advantages over other routes like reduced adverse effects, less systemic absorption, and avoidance of first-pass effect and degradation in the gastrointestinal tract (GIT). (eurekaselect.com)
Conditions › Back Pain › Low Back Pain › Non-steroidal Anti-inflammatory Drugs (NSAIDs) in the Treatm. (spineuniverse.com)
Aspirin is the prototypical member of the group of medications known as non-steroidal anti-inflammatory drugs (NSAIDs) . (spineuniverse.com)
A reduction in their local concentration could therefore explain the combined anti-inflammatory and analgesic properties of NSAIDs. (spineuniverse.com)
Most NSAIDs do not decrease the production of lipoxygenase-produced leukotrienes (causes inflammation and allergic reactions), which are also believed to significantly contribute to the inflammatory response. (spineuniverse.com)
A disparity between the anti-inflammatory and analgesic potencies of these agents in clinical practice has been observed, and recent data has suggested that pain relief from NSAIDs may in part be secondary to a more central anti-nociceptive component. (spineuniverse.com)
With the recently expanded sales and marketing of over-thecounter ibuprofen and naproxen, additional increases in the already widespread use of nonsteroidal antiinflammatory drugs (NSAIDs) [3] is likely. (thefreelibrary.com)
With the exception of acetaminophen and tramadol, the above analgesics, also classified as NSAIDs, are indicated for the treatment of acute or chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute pericarditis, and Kawasaki's disease. (thefreelibrary.com)
The most common causes are bacteria and use of nonsteroidal anti-inflammatory drugs ( NSAIDs ). (medicalnewstoday.com)
Epidemiological studies suggest reduced AD risk associates with long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs). (jneurosci.org)
Several epidemiological studies have demonstrated a reduced risk for AD in patients using nonsteroidal anti-inflammatory drugs (NSAIDs), prompting further inquiries about how NSAIDs might influence the development of AD pathology and inflammation in the CNS. (jneurosci.org)
ABSTRACT: Although nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed and consumed drug classes, they are associated with a wide range of adverse effects, including NSAID-induced hypersensitivity reactions (NHRs). (uspharmacist.com)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used analgesic, anti-inflammatory, and antipyretic medications on the market. (uspharmacist.com)
CSIs are equivalent to non-steroidal anti-inflammatory drugs (NSAIDs) as anti-inflammatory agents. (mja.com.au)
are they safer than non-steroidal anti-inflammatory drugs (NSAIDs) in patients with hypertension and renal impairment? (mja.com.au)
To evaluate the effect of the topical steroid, fluorometholone, and the non-steroidal anti-inflammatory drugs (NSAIDs), nepafenac and ketorolac, on inflammatory cytokine expression of the ocular surface in the botulium toxin B-induced murine dry eye model. (molvis.org)
Topical fluorometholone caused suppression of inflammatory cytokine expression on the ocular surface in the Botulium toxin B-induced murine dry eye model, while topical NSAIDs demonstrated no clearly beneficial effects. (molvis.org)
There are three general classes of drugs commonly used in the treatment of rheumatoid arthritis: non-steroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying anti-rheumatic drugs (DMARDs). (hopkinsarthritis.org)
Aspirin is the oldest drug of the non-steroidal class, but because of its high rate of GI toxicity, a narrow window between toxic and anti-inflammatory serum levels, and the inconvenience of multiple daily doses, aspirin's use as the initial choice of drug therapy has largely been replaced by other NSAIDs. (hopkinsarthritis.org)

Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity. (semanticscholar.org)
Association of Aspirin and Other Nonsteroidal Anti - inflammatory Drugs With Vertebral Trabecular Bone: Data From Multiethnic Study of Atherosclerosis, a Population-Based Multicenter Cohort Study. (wroc.pl)
Risk of congenital anomalies in pregnant users of non-steroidal anti-inflammatory drugs: A nested case-control study. (nih.gov)
Nonsteroidal anti-inflammatory drugs (including diclofenac ) may rarely increase the risk for a heart attack or stroke . (webmd.com)
Some nonsteroidal antiinflammatory drugs can significantly increase C-reactive protein levels. (greenmedinfo.com)
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury. (painpluscpn.ca)
Reduced conscious blood flow in the stomach during non-steroidal anti-inflammatory drugs administration assessed by flash echo imaging. (biomedsearch.com)
Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. (springer.com)
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. (cancer.gov)
Many drugs are available in the market for inflammatory diseases. (hindawi.com)
Inflammatory diseases are mainly treated with nonsteroidal anti-inflammatory drugs and steroidal drugs [ 1 ]. (hindawi.com)
Analgesic drugs comprise the largest category of pharmaceutical agents consumed by individuals in the United States. (thefreelibrary.com)
One major concern is that the analgesic class of drugs accounted for more exposures reported to the American Association of Poison Control Centers in 1995 than did any other category of pharmaceutical agents (3). (thefreelibrary.com)
Side effect issues could be overcome using alternative anti-inflammatory drugs directed against different inflammatory targets. (jneurosci.org)
The availability of the COX-2-specific inhibitor (CSI) class of anti-inflammatory drugs, namely celecoxib and rofecoxib, has raised a number of questions. (mja.com.au)
All of these drugs also have mild to moderate analgesic properties independent of their anti-inflammatory effect. (hopkinsarthritis.org)

Diclofenac is known as a nonsteroidal anti-inflammatory drug (NSAID). (webmd.com)

The inner coat consists of an acrylic based resin, Eudragit S, which dissolves at pH 7 or greater, releasing mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon . (rxlist.com)
DELZICOL (mesalamine) delayed-release capsules contain acrylic based resin, Eudragit S (methacrylic acid copolymer type B, NF), which dissolves at pH 7 or greater and releases mesalamine in the terminal ileum and beyond for topical anti-inflammatory action in the colon . (rxlist.com)
IMSEAR at SEARO: Pre-operative use of the topical steroidal and non-steroidal anti-inflammatory agents to maintain intra-operative mydriasis during cataract surgery. (who.int)
This paper summarizes the currently accepted concepts of the pathogenetic mechanisms underlying the morphological and functional changes in intranasal mucosa of the patients having a long history of the application of the long-acting topical vasoconstrictor agents. (bireme.br)
This current study was designed to investigate whether topical fluorometholone, ketorolac and nepafenac inhibit inflammatory cytokine expression on the ocular surface in the BTX-B-induced murine dry eye model. (molvis.org)

The purpose of this study is to evaluate the efficacy of TAK-438, once daily (QD), compared to AG-1749 (Lansoprazole) in patients with a history of gastric or duodenal ulcer who require long-term therapy of non-steroidal anti-Inflammatory drug (NSAID). (clinicaltrials.gov)
A Phase 3, Multicenter, Randomized, Double-blind, AG-1749-controlled, Parallel-group, Comparison Study to Evaluate the Efficacy and Safety of TAK-438 (10 mg or 20 mg, Orally, Once Daily) for the Prevention of Recurrent Gastric or Duodenal Ulcers During Long-term Therapy of Non-steroidal Anti-inflammatory Drug (NSAID). (clinicaltrials.gov)
The dosing and cost of each NSAID varies significantly by chemical family and agent. (spineuniverse.com)
The present invention is directed to a pharmaceutical composition and method for the treatment of rhinitis and cold-like symptoms which includes a non-steroidal anti-inflammatory drug (NSAID), a decongestant, and an antihistamine. (google.com)
It has been found that an NSAID enhances the activity of a decongestant and an anti-histamine, thus permitting a reduction in either or both in administration of separate dosage forms. (google.com)

Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. (bmj.com)
There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. (bmj.com)
The most common antiplatelet agent prescribed is a small dose of aspirin (Aspec®, Cartia®, Cardiprin® and others). (dermnetnz.org)

During an inflammatory response, mediators such as various inflammatory mediators are released into the rat paw tissue, such as prostaglandins (PGE2), leukotrienes (LTD4), nitric oxide (NO), and oxygen reactive species. (hindawi.com)
These inflammatory mediators have potential to continue stimulating the inflammatory response and its perpetuation [ 2 ]. (hindawi.com)
These events are induced by inflammatory mediators which bind to specific receptors on inflammatory and endothelial cells. (hindawi.com)
Prostaglandins are active mediators of the inflammatory cascade, which also serve to sensitize peripheral nociceptors (nerve endings). (spineuniverse.com)
COX-1 inhibition shifts the arachidonic acid pathway from the production of the protective anti-inflammatory prostaglandins toward the production of the proinflammatory mediators, eosinophils, and mast cells. (uspharmacist.com)

Anti-inflammatory doses of ibuprofen: effect on neutrophils and exercise-induced muscle injury. (biomedsearch.com)
The purpose of the study was to determine the effect of anti-inflammatory doses of ibuprofen on neutrophils, neutrophil O2* production, and markers of muscle injury. (biomedsearch.com)
In conclusion, anti-inflammatory doses of ibuprofen reduced CK activity but not the neutrophil response or other indirect markers of muscle injury during recovery from eccentric arm exercise. (biomedsearch.com)
Ibuprofen also decreased the numbers of ubiquitin-labeled dystrophic neurites and the percentage area per plaque of anti-phosphotyrosine-labeled microglia. (jneurosci.org)
Thus, the anti-inflammatory drug ibuprofen, which has been associated with reduced AD risk in human epidemiological studies, can significantly delay some forms of AD pathology, including amyloid deposition, when administered early in the disease course of a transgenic mouse model of AD. (jneurosci.org)

Sulfasalazine (SSZ) is a commonly used drug in the treatment of inflammatory diseases such as rheumatoid arthritis and Crohn's disease. (tudelft.nl)
Global health initiatives are encumbered by a vast majority of the population suffering from non-communicable inflammatory diseases such as cardiovascular disease, neurodegeneration, diabetes, arthritis, ulcerative colitis/bowel disease and cancer. (biomedcentral.com)

Have analgesic, anti-inflammatory, and antipyretic activities. (medscape.com)

Synergistic enhancement of production of proinflammatory cytokines of human peripheral blood monocytes by anti-Sm and anti-RNP antibodies. (bioportfolio.com)
In our previous study, the oxLDL/βGPI/anti-βGPI complex was demonstrated to further enhance the foam cell formation and migration of VSMC, as well as the expression of inflammatory cytokines, via th. (bioportfolio.com)
The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits. (jneurosci.org)
The pro-inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) were evaluated by immunohistochemistry. (molvis.org)

The present study was performed to elucidate the roles of serum anti-Sm antibodies in the pathogenesis of systemic lupus erythematosus (SLE). (bioportfolio.com)

Experimental model of carrageenan-induced acute inflammation produces a range of inflammatory responses, due to the increase in the response to chemoattractants increasing PMN migration to the sites of inflammation [ 3 ]. (hindawi.com)
Given the known limitations in Western medicine to treat a broad range of inflammatory related illness as well as the emergence of antibiotic resistance, there is a renewed interest in complementary and alternative medicines (CAMs) to achieve these means. (biomedcentral.com)

12. A method according to claim 1 wherein said agent is delivered into the posterior segment of the eye by initially administering the agent to the anterior segment of the eye in a form and dose that is sufficient to cause a therapeutic amount of the agent to distribute to the posterior segment. (google.com.au)
The objective of this study is to assess whether FDG (18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose) PET-CT could be an early predictive method of therapeutic response to anti-PD-1 imm. (bioportfolio.com)
New therapeutic agents provide interesting new options for Patienten with difficult-to-treat gouty arthritis. (springer.com)

A derivative of acetyl salicylic acid recently synthesized, acid 5-(2,4-difluorenil)-salicylate (diflunisal), seems to be endowed with an elevated anti-phlogistic and analgesic activity 1-4 . (springer.com)
Significant pain relief occurred within 2 days of the initiation of treatment, and maximum anti-inflammatory and analgesic activity, evident within 2 weeks, was sustained throughout the 12-week study. (curehunter.com)

To evaluate this traditional medicinal effect, we investigated the anti-chronic inflammatory effect of Radix Ophiopogonis on senescent cells. (nih.gov)

The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. (springer.com)

Micardis HCT may be used alone or in combination with other antihypertensive agents. (drugs.com)
Captopril is effective alone and in combination with other antihypertensive agents, especially thiazide -type diuretics . (wikidoc.org)

10. The drug delivery device of claim 5 wherein said body is impermeable to said pharmaceutically active agent. (google.de)
12. The drug delivery device of claim 5 wherein said inner core comprises a semi-solid form, and said pharmaceutically active agent is disposed within said semi-solid form. (google.de)
15. The drug delivery device of claim 1 wherein said pharmaceutically active agent is nepafenac. (google.de)
17. The drug delivery device of claim 1 wherein said pharmaceutically active agent comprises eliprodil. (google.de)
3. The resorbable drug delivery system of claim 1, wherein the binding agent is a hydrolyzed collagen or hydrolyzed elastin of a molecular weight of about 2500-4000. (google.com.au)
The anti-inflammatory activity of the methanol extract of the dried fruits shows that the presence of potential constituents present in this extract may provide assistance in the drug discovery process. (hindawi.com)

Topically applicable compositions in the form of oil-in-water (O/W) emulsions contain a pro-penetrating system including at least one glycol and at least one additional pro-penetrating agent, a suitable emulsifying system and at least one active agent of the family of steroidal anti-inflammatory agents, and are useful e.g., for the treatment of psoriasis. (freepatentsonline.com)

These proinflammatory agents can then induce the overproduction of cysteinyl leukotrienes (CysLTs), which causes an increase of CysLTs receptor expression in the bronchial muscles, as well as the endothelial and epithelial cells. (uspharmacist.com)

Masazumi Ikeda , Synthesis of ketoprofen, a potent non-steroidal anti-inflammatory agent, and its Sila analogue, El-Minia Med. (who.int)

Non-steroidal chemical compounds with abortifacient activity. (nih.gov)
Steroidal compounds with abortifacient activity. (nih.gov)
These findings emphasize and validate the previous work of others and identify the most effective CAM anti-inflammatory, antibacterial compounds using these models. (biomedcentral.com)

Peptic ulcer and non-steroidal anti-inflammatory agents. (bmj.com)

Acute systemic inflammatory response syndrome arising from infection can lead to multiple organ failure and death, with greater susceptibility occurring in immunocompromised individuals. (biomedcentral.com)

Because of the extensive use of these agents, adverse events that occur infrequently may still affect the overall risk/benefit ratio of this class of medications. (nih.gov)

Tylenol (acetaminophen) is not an anti-inflammatory medicine and is not likely to help. (wikihow.com)

Influence of protein deficiency of lysosome stabilizing and paw edema suppressant activity of steroidal and nonsteroidal anti-inflammatory agents in rats. (aspetjournals.org)
In the present study, we examined the anti-inflammatory effects of dried fruit methanol extract on carrageenan-induced hind paw edema in rats. (hindawi.com)
Diosgenin Protects Rats from Myocardial Inflammatory Injury Induced by Ischemia-Reperfusion. (bioportfolio.com)

A murine IgG1 monoclonal anti-idiotype antibody, containing a variable antigen-binding region that functionally mimics the three-dimensional structure of a specific epitope on the ovarian cancer tumor-associated antigen CA-125, with potential antineoplastic activity. (cancer.gov)
However, its anti-metastatic activity rem. (bioportfolio.com)

Acute rat paw inflammation is caused by the migration of inflammatory cells into the microvascular system and fluid entering the interstitial tissue. (hindawi.com)
The major effect of these agents is to reduce acute inflammation thereby decreasing pain and improving function. (hopkinsarthritis.org)

A. delivering into the posterior segment of the eye a therapeutically effective amount of an agent that comprises urea or a urea derivative or mixtures thereof. (google.com.au)

A pilot study to examine the effects of an anti-inflammatory supplement on eicosanoid derivatives in patients with chronic kidney disease. (greenmedinfo.com)

Check for active clinical trials using this agent. (cancer.gov)
Anti-inflammatory therapy may be beneficial for dry eye treatment which has been reported in a series of animal and clinical trials. (molvis.org)

3. Use according to either of the preceding claims, characterized in that the bradykinin antagonist is chosen from optionally modified, natural or synthetic peptides, natural or synthetic chemical molecules, antisense nucleic acids, ribozymes, anti-bradykinin antibodies, soluble bradykinin receptors, anti-bradykinin-receptor antibodies or bradykinin receptor antagonists. (freepatentsonline.com)

Anti-inflammatory effects of 5-HT3 receptor antagonists in interleukin-1beta stimulated primary human chondrocytes. (semanticscholar.org)
A number of studies report anti-inflammatory effects from Zeel. (isharonline.org)
Anti-arrhythmogenic and anti-inflammatory effects of troxerutin in ischemia/reperfusion injury of diabetic myocardium. (bioportfolio.com)
Anti-proliferation and anti-metastatic effects of sevoflurane on human osteosarcoma U2OS and Saos-2 cells. (bioportfolio.com)
To sum up, our results evidenced that sevoflurane exerted anti-proliferative and anti-metastatic effects on osteosarcoma cells by inactivating PI3K/AKT pathway. (bioportfolio.com)
Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with Capecitabine (Cap) and/or Irinoteca. (bioportfolio.com)
The biphasic effects of the oxLDL/βGPI/anti-βGPI complex on VSMC proliferation and apoptosis. (bioportfolio.com)
Resveratrol: Review on its discovery, pharmacokinetics and anti-leukemia effects. (bioportfolio.com)
This caution was taken given that many plants exert tumoricidal and anti-inflammatory effects at close range through similar signaling pathways, which could lead to false positives. (biomedcentral.com)

For example, using Mucor hiemalis, the breakdown of products which are toxic in traditional water treatment, such as phenols and pigments of wine distillery wastewater, X-ray contrast agents, and ingredients of personal care products, can be broken down in a non-toxic way. (wikipedia.org)

Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (nih.gov)

Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. (pharmacycode.com)

BACKGROUND Diosgenin, a phytosteroid sapogenin, has anti-inflammatory properties shown to reduce myocardial ischemia-reperfusion injury (MIRI). (bioportfolio.com)

Data validation studies establish hydrocortisone and dexamethasone as suppressing multiple pro-inflammatory processes, where L-NIL suppressed NO2-, but had no effect on iNOS expression or IL-6. (biomedcentral.com)

The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during is. (bioportfolio.com)

This is an open label, single-arm, phase IB treatment study to determine the safety of administering anti-PD1 monoclonal antibodies with AV-MEL-1 and to get some suggestion of efficacy, in. (bioportfolio.com)

Anti-Inflammatory Agents, Non-Steroidal

Inflammation

Okadaic Acid

Lipopolysaccharides

Transcription Factor RelA

Tumor Necrosis Factor-alpha

Inflammation Mediators

I-kappa B Kinase

I-kappa B Proteins

NF-kappa B

Interleukin-1

Steroids

Tetradecanoylphorbol Acetate

Macrophages

Cells, Cultured

Spirostans

Gene Expression Regulation

Saponins

Glycosides

Diosgenin

Tomatine

Liliaceae

Solanaceous Alkaloids

Chlormadinone Acetate

Molecular Structure

Pregnanes

Cynanchum

Androstanes

Estrogen Antagonists

Rhizome

Magnetic Resonance Spectroscopy

Dracaena

Smilax

Buxaceae

Solanum

Dioscorea

Allium

Aromatase Inhibitors

Withanolides

Plant Extracts

Testolactone

Holarrhena

Estradiol

Anemarrhena

Hydroxysteroids

Stereoisomerism

Molecular Conformation

Asparagus Plant

Spectrometry, Mass, Fast Atom Bombardment

Solanum nigrum

Alveolectomy

Androstenes

Withania

Agave

Ophiopogon

Chloroquinolinols

Trillium

Tropaeolaceae

Gestrinone

Phytosterols

Hemolytic Agents

Convallaria

Androstanols

Marsdenia

Solanaceae

Agavaceae

Fritillaria

Estrogens

Pregnenes

Veratrum

Hosta

Cyproterone Acetate

Solanine

Subgingival Curettage