Anti inflammatory agents non steroidal. Medical search

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)

Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)

A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Cholestane derivatives containing a fused lactone ring at the 16,17-position and a spiroglycosidic linkage at C-22. Members include sarsaponin, DIOSGENIN and yamogenin.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.

Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)

A spirostan found in DIOSCOREA and other plants. The 25S isomer is called yamogenin. Solasodine is a natural derivative formed by replacing the spiro-ring with a nitrogen, which can rearrange to SOLANINE.

An alkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. (From The Merck Index, 11th ed)

A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.

Alkaloids, mainly tropanes, elaborated by plants of the family Solanaceae, including Atropa, Hyoscyamus, Mandragora, Nicotiana, Solanum, etc. Some act as cholinergic antagonists; most are very toxic; many are used medicinally.

An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Saturated derivatives of the steroid pregnane. The 5-beta series includes PROGESTERONE and related hormones; the 5-alpha series includes forms generally excreted in the urine.

A plant genus of the family ASCLEPIADACEAE. Members contain steroidal glycosides and cytotoxic phenanthroindolizidine N-oxide alkaloids.

The family of steroids from which the androgens are derived.

Compounds which inhibit or antagonize the action or biosynthesis of estrogenic compounds.

Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

A plant genus of the family LILIACEAE. The common name of "dragon's blood" is also used for CROTON and Daemonorops (ARECACEAE).

A plant genus of the family SMILACACEAE. Members contain smiglasides (phenylpropanoid glycosides) and steroidal saponins. Commercially it is sometimes adulterated with HEMIDESMUS, which would affect experimental results.

A plant family of the order Euphorbiales, subclass Rosidae, class Magnoliopsida. Leaves are alternate, simple, and leathery. Fruits are one- or two-seeded capsules or drupes (stony-pitted fleshy fruits).

A plant genus of the family SOLANACEAE. Members contain SOLANACEOUS ALKALOIDS. Some species in this genus are called deadly nightshade which is also a common name for ATROPA BELLADONNA.

A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.

A genus of the plant family Liliaceae (sometimes classified as Alliaceae) in the order Liliales. Many produce pungent, often bacteriostatic and physiologically active compounds and are used as VEGETABLES; CONDIMENTS; and medicament, the latter in traditional medicine.

Compounds that inhibit AROMATASE in order to reduce production of estrogenic steroid hormones.

Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

An antineoplastic agent that is a derivative of progesterone and used to treat advanced breast cancer.

A plant genus of the family APOCYNACEAE. Members contain holarrhenine (a steroidal alkaloid) and TRICHOTHECENES.

The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.

A plant genus of the family LILIACEAE. Members contain anemarans (POLYSACCHARIDES), hinokiresinol, mangiferin (a xanthone), and timosaponin (a steroidal saponin).

Steroids in which one or more hydroxy groups have been substituted for hydrogen atoms either within the ring skeleton or on any of the side chains.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

The characteristic three-dimensional shape of a molecule.

A plant genus in the family LILIACEAE (sometimes placed in Asparagaceae) that contains ECDYSTEROIDS and is an ingredient of Siotone. The shoots are used as a vegetable and the roots are used in FOLK MEDICINE.

A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.

A plant species of the genus SOLANUM, family SOLANACEAE that contains steroidal glycosides.

Subtotal or complete excision of the alveolar process of the maxilla or mandible. (Dorland, 28th ed)

Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.

A plant genus of the family SOLANACEAE. Members contain withanolides. Withania somnifera is the source of ashwagandha and aswal.

A genus known for fibers obtained from their leaves: sisal from A. sisalana, henequen from A. fourcroyoides and A. cantala, or Manila-Maguey fiber from A. cantala. Some species provide a sap that is fermented to an intoxicating drink, called pulque in Mexico. Some contain agavesides.

A plant genus of the family LILIACEAE. Members contain steroidal glycosides and provide an ingredient of shengmaisan (DRUGS, CHINESE HERBAL).

8-Hydroxyquinolinols chlorinated on the number 5 and/or 7 carbon atom(s). They are antibacterial, antiprotozoal, and antidiarrheal, especially in amebiasis, and have also been used as antiseborrheics. The compounds are mostly used topically, but have been used also as animal feed additives. They may cause optic and other neuropathies and are most frequently administered in combination with other agents.

A plant genus of the family LILIACEAE that is a short plant with a distinct whorl of 3 broad leaves.

A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.

A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.

A class of organic compounds known as STEROLS or STEROIDS derived from plants.

Substances that are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.

A plant genus of the family LILIACEAE that contains CARDIAC GLYCOSIDES.

Androstanes and androstane derivatives which are substituted in any position with one or more hydroxyl groups.

A plant genus of the family ASCLEPIADACEAE. Members contain pregnane glycosides (marsdekoiside & marstomentosides, maryal) and hainaneosides (SAPONINS).

A plant family of the order Solanales, subclass Asteridae. Among the most important are POTATOES; TOMATOES; CAPSICUM (green and red peppers); TOBACCO; and BELLADONNA.

A plant family of the order Liliales, subclass Liliidae, class Liliopsida. Members of the family have narrow, lance-shaped, sometimes fleshy or toothed leaves that are clustered at the base of each plant. Most species have large flower clusters containing many flowers. The fruit is a capsule or berry.

A plant genus of the family LILIACEAE. Members of this genus produce imperialine, a steroidal alkaloid which acts at muscarinic receptors.

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

Unsaturated derivatives of PREGNANES.

A plant genus of the family LILIACEAE with roots that contain VERATRUM ALKALOIDS used as emetics, parasiticides, antihypertensives. It is the main ingredient of Boicil.

A plant genus of the family LILIACEAE. Members contain steroidal saponins.

An agent with anti-androgen and progestational properties. It shows competitive binding with dihydrotestosterone at androgen receptor sites.

A mixture of alpha-chaconine and alpha-solanine, found in SOLANACEAE plants.

Removal of degenerated and necrotic epithelium and underlying connective tissue of a periodontal pocket in an effort to convert a chronic ulcerated wound to an acute surgical wound, thereby insuring wound healing and attachment or epithelial adhesion, and shrinkage of the marginal gingiva. The term is sometimes used in connection with smoothing of a root surface or ROOT PLANING. (Jablonski; Illustrated Dictionary of Dentistry, 1982)

Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension. (1/7426)

OBJECTIVE: To investigate the usefulness of hydroxychloroquine (HCQ) dose-loading to increase the percentage of responders or rate of response in treating rheumatoid arthritis (RA). METHODS: Two hundred twelve patients with early RA (mean duration 1.5 years) were enrolled in a 24-week trial. Patients were stabilized with 1,000 mg naproxen/day and then began a 6-week, double-blind trial comparing treatment with HCQ at 400 mg/day (n = 71), 800 mg/day (n = 71), and 1,200 mg/day (n = 66), followed by 18 weeks of open-label HCQ treatment at 400 mg/day. RESULTS: All patients had mild, active disease at the time of initiation of HCQ treatment (31-43% rheumatoid factor positive; no previous disease-modifying antirheumatic drugs; mean swollen joint count 8.6-10.4). Based on the Paulus criteria, response during the 6-week double-blind portion of the study was 47.97%, 57.7%, and 63.6% in the 400 mg/day, 800 mg/day, and 1,200 mg/day groups, respectively (P = 0.052). Discontinuations for adverse events were dose related (3 in the 400 mg/day group, 5 in the 800 mg/day group, 6 in the 1,200 mg/day group). Most involved the gastrointestinal (GI) system, with the background naproxen treatment possibly contributing. Ocular abnormalities occurred in 17 of 212 patients (8%) but were not dose related. CONCLUSION: Dose-loading with HCQ increased the degree of response at 6 weeks in this group of patients with early, predominantly seronegative RA. Adverse GI events were dose related, while adverse ocular events were not. (+info)

Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. (2/7426)

Apoptosis plays a major role in gastrointestinal epithelial cell turnover, ulcerogenesis and tumorigenesis. We have examined apoptosis induction by non-steroidal anti-inflammatory drugs (NSAIDs) in human gastric (AGS) cancer cells and the role of protein kinase C (PKC) and apoptosis-related oncogenes. After treatment with aspirin or indomethacin, cell growth was quantified by MTT assay, and apoptosis was determined by acridine orange staining, DNA fragmentation and flow cytometry. The mRNA and protein of p53, p21waf1/cip1 and c-myc was detected by Northern and Western blotting respectively. The influence of PKC on indomethacin-induced apoptosis was determined by co-incubation of 12-O-tetradecanoylphorbol 13-acetate (TPA). The role of c-myc was determined using its antisense oligonucleotides. The results showed that both aspirin and indomethacin inhibited cell growth and induced apoptosis of AGS cells in a dose- and time-dependent manner, without altering the cell cycle. Indomethacin increased c-myc mRNA and protein, whereas p53 and p21wafl/cip1 were unchanged. Down-regulation of c-myc by its antisense oligonucleotides reduced apoptosis induction by indomethacin. TPA could inhibit indomethacin-induced apoptosis and accumulate cells in G2/M. Overexpression of c-myc was inhibited by TPA and p21waf1/cip1 mRNA increased. In conclusion, NSAIDs induce apoptosis in gastric cancer cells which may be mediated by up-regulation of c-myc proto-oncogene. PKC activation can abrogate the effects of NSAIDs by decreasing c-myc expression. (+info)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (3/7426)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted. (+info)

Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. (4/7426)

LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7.3 x 10(-6) mole fraction, which approached the stiochiometric limit of this assay. The true potency of LY315920 was defined using a deoxycholate/phosphatidylcholine assay with a mole fraction of 1.5 x 10(-6). LY315920 was 40-fold less active against human, group IB, pancreatic sPLA2 and was inactive against cytosolic PLA2 and the constitutive and inducible forms of cyclooxygenase. Human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells was inhibited by LY315920 with an IC50 of 0.79 microM. The release of TXA2 from these cells by N-formyl-methionyl-leucyl-phenylalanine or arachidonic acid was not inhibited. The i.v. administration of LY315920, 5 min before harvesting the bronchoalveolar lavage cells, resulted in the inhibition of sPLA2-induced production of TXA2 with an ED50 of 16.1 mg/kg. Challenge of guinea pig lung pleural strips with sPLA2 produced contractile responses that were suppressed in a concentration-dependent manner by LY315920 with an apparent KB of 83 +/- 14 nM. Contractile responses induced by arachidonic acid were not altered. Intravenous or oral administration of LY315920 to transgenic mice expressing the human sPLA2 protein inhibited serum sPLA2 activity in a dose-related manner over a 4-h time course. LY315920 is a potent and selective sPLA2 inhibitor and represents a new class of anti-inflammatory agent designated SPI. This agent is currently undergoing clinical evaluation and should help to define the role of sPLA2 in various inflammatory disease states. (+info)

Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. (5/7426)

The marked analgesic efficacy of ketorolac in humans, relative to other nonsteroidal anti-inflammatory drugs (NSAIDs), has lead to speculation as to whether additional non-NSAID mechanism(s) contribute to its analgesic actions. To evaluate this possibility, we characterized (R,S)-ketorolac's pharmacological properties in vivo and in vitro using the nonselective cyclooxygenase (COX) inhibitors [indomethacin (INDO) and diclofenac sodium (DS)] as well as the selective COX-2 inhibitor, celecoxib, as references. The potency of racemic (R,S)-ketorolac was similar in tests of acetic acid-induced writhing, carrageenan-induced paw hyperalgesia, and carrageenan-induced edema formation in rats; ID50 values = 0.24, 0. 29, and 0.08 mg/kg, respectively. (R,S)-ketorolac's actions were stereospecific, with (S)-ketorolac possessing the biological activity of the racemate in the above tests. The analgesic potencies for (R,S)-, (S)-, and (R)-ketorolac, INDO, and DS were highly correlated with their anti-inflammatory potencies, suggesting a common mechanism. (R,S)-ketorolac was significantly more potent than INDO or DS in vivo. Neither difference in relative potency of COX inhibition for (R,S)-ketorolac over INDO and DS nor activity of (S)-ketorolac at a number of other enzymes, channels, or receptors could account for the differences in observed potency. The distribution coefficient for (R,S)-ketorolac was approximately 30-fold less than for DS or INDO, indicating that (R,S)-ketorolac is much less lipophilic than these NSAIDs. Therefore, the physicochemical and pharmacokinetics properties of (R,S)-ketorolac may optimize the concentrations of (S)-ketorolac at its biological target(s), resulting in greater efficacy and potency in vivo. (+info)

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (6/7426)

1. Subcutaneous injection of sodium deoxycholic acid into the anterior of the back of male ddY mice elicited dose-dependent scratching of the injected site with the forepaws and hindpaws. 2. Up to 100 microg of sodium deoxycholic acid induced no significant increase in vascular permeability at the injection site as assessed by a dye leakage method. 3. Bradykinin (BK) B2 receptor antagonists, FR173657 and Hoe140, significantly decreased the frequency of scratching induced by sodium deoxycholic acid. 4. Treatment with aprotinin to inhibit tissue kallikrein reduced the scratching behaviour induced by sodium deoxycholic acid, whereas treatment with soybean trypsin inhibitor to inhibit plasma kallikrein did not. 5. Although injection of kininase II inhibitor, lisinopril together with sodium deoxycholic acid did not alter the scratching behaviour, phosphoramidon, a neutral endopeptidase inhibitor, significantly increased the frequency of scratching. 6. Homogenates of the skin excised from the backs of mice were subjected to gel-filtration column chromatography followed by an assay of kinin release by trypsin from each fraction separated. Less kinin release from the fractions containing kininogen of low molecular weight was observed in the skin injected with sodium deoxycholic acid than in normal skin. 7. The frequency of scratching after the injection of sodium deoxycholic acid in plasma kininogen-deficient Brown Norway Katholiek rats was significantly lower than that in normal rats of the same strain, Brown Norway Kitasato rats. 8. These results indicate that BK released from low-molecular-weight kininogen by tissue kallikrein, but not from high-molecular-weight kininogen by plasma kallikrein, may be involved in the scratching behaviour induced by the injection of sodium deoxycholic acid in the rodent. (+info)

The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. (7/7426)

To determine whether declining semen quality associated with health problems may be due to certain antibiotic or anti-inflammatory treatments, semen was collected 3 times per week for up to 42 d from 6 normal bulls after treatment with oxytetracycline, tilmicosin, dihydrostreptomycin, or phenylbutazone. No adverse effects on semen quality were observed. (+info)

Pseudogout attack associated with chronic thyroiditis and Sjogren's syndrome. (8/7426)

A 66-year-old woman, diagnosed with chronic thyroiditis at age 63, presented with anorexia and fatigue. Therapy for the chronic thyroiditis consisted of levothyroxine sodium (100 microg/day). Her symptoms were attributed to the insufficient supply of levothyroxine sodium. Following a dosage increase to 150 microg/day, she suffered from an acute attack of pseudogout. Clinical features were complicated by Sjogren's syndrome, which appeared after treatment onset. Pseudogout was effectively treated by colchicine after administration of diclofenac sodium failed to alleviate the symptoms. Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjogren's syndrome has not been previously reported. (+info)

Among them are serotonin, a neurotransmitter; indometacin, a non-steroidal anti-inflammatory agent; L-761,066, a COX-2 ...

https://en.wikipedia.org/wiki/Nenitzescu_indole_synthesis

Kontogiorgis CA, Hadjipavlou-Litina DJ (January 2002). "Non steroidal anti-inflammatory and anti-allergy agents". Current ... The anti-IL-20 antibody has been shown to reduce the severity of RA in rats, mitigate bone destruction, and more. The anti-IL- ... Due to the clear association of IL-20 with RA, anti-IL-20 antibody is now in a clinical trial for RA. Anti-IL-20 monoclonal ... Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS (August 2011). "Anti-IL-20 monoclonal antibody inhibits the differentiation ...

https://en.wikipedia.org/wiki/Interleukin_20

... oral analgesia with non-steroidal anti-inflammatory agents (NSAIDS); and topical analgesia with lidocaine, ice and heat. ... anti-inflammatory medications such as nonsteroidal anti-inflammatory drugs, traction, or epidural steroid injection can provide ...

https://en.wikipedia.org/wiki/Degenerative_disc_disease

Dahl SL, Ward JR (1982). "Pharmacology, clinical efficacy, and adverse effects of the non-steroidal anti-inflammatory agent ... Somerville KW, Hawkey CJ (January 1986). "Non-steroidal anti-inflammatory agents and the gastrointestinal tract". Postgraduate ... It is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, and was marketed under the brand name Opren ... Unlike other non-steroidal anti-inflammatory drugs, benoxaprofen acts directly on mononuclear cells. It inhibits their ...

https://en.wikipedia.org/wiki/Benoxaprofen

Ruscogenins function as anti-inflammatory agents and are also believed to cause constriction in veins. Currently the mode of ... The major phytochemicals in butcher's broom are steroidal saponins. Saponins occur naturally in plants as glycosides and have ... "Possible mechanism of the anti-inflammatory activity of ruscogenin: role of intercellular adhesion molecule-1 and nuclear ... Sahu, N. P.; Banerjee, S.; Mondal, N. B.; Mandal, D. (2008), "Steroidal Saponins", Fortschritte der Chemie organischer ...

https://en.wikipedia.org/wiki/Ruscus_aculeatus

Cochrane Eyes and Vision Group) (February 2015). "Topical non-steroidal anti-inflammatory agents for diabetic cystoid macular ... steroidal anti‐inflammatory agents. Instead of laser surgery, some people require a vitrectomy to restore vision. A vitrectomy ... Injection of anti-VEGF drugs or steroids can reduce diabetic retinopathy progression in around half of eyes treated; however, ... It is often more prudent to inject triamcinolone or anti-VEGF drugs. In some patients it results in a marked increase of vision ...

https://en.wikipedia.org/wiki/Diabetic_retinopathy

... a non-steroidal anti-inflammatory agent". Journal of Pharmacobio-Dynamics. 11 (9): 612-9. doi:10.1248/bpb1978.11.612. PMID ... Amfenac, also known as 2-amino-3-benzoylbenzeneacetic acid, is a nonsteroidal anti-inflammatory drug (NSAID) with acetic acid ... Nonsteroidal anti-inflammatory drugs, 2-Aminobenzophenones, Acetic acids, All stub articles, Musculoskeletal system drug stubs) ...

https://en.wikipedia.org/wiki/Amfenac

Sivaprasad, Sobha; Bunce, Catey; Crosby-Nwaobi, Roxanne (2012-02-15). "Non-steroidal anti-inflammatory agents for treating ... and antiviral agents for herpes simplex virus. "Cataract in the Adult Eye PPP - 2016". American Academy of Ophthalmology. 2016- ...

https://en.wikipedia.org/wiki/Cochrane_Eyes_and_Vision

... two novel series of non-steroidal anti-inflammatory agents. This article was published in Nature in 1968. In December 1988, ... Two Novel Series of Non-steroidal Anti-inflammatory Agents". Nature. 219 (5150): 164. Bibcode:1968Natur.219..164B. doi:10.1038/ ... Wang, Runsheng (6 Aug 2015). "Comparative efficacy of non-steroidal anti-inflammatory drugs in ankylosing spondylitis: a ... Following the filing of the patent, the first description of oxaprozin exhibiting anti-inflammatory properties was outlined in ...

https://en.wikipedia.org/wiki/Oxaprozin

"Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents". Current Drug ...

https://en.wikipedia.org/wiki/Estradiol_sulfate

Jones P, Lamdin R, Dalziel SR (August 2020). "Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for ... Jaturapatporn D, Isaac MG, McCleery J, Tabet N (February 2012). "Aspirin, steroidal and non-steroidal anti-inflammatory drugs ... Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases ... Danelich IM, Wright SS, Lose JM, Tefft BJ, Cicci JD, Reed BN (May 2015). "Safety of non-steroidal anti-inflammatory drugs in ...

https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug

... is a non-steroidal anti-inflammatory agent with analgesic and antipyretic activity similar to phenylbutazone. It is ...

https://en.wikipedia.org/wiki/Ditazole

Topical or oral non-steroidal anti-inflammatory agents may be used to avoid steroid-induced complications like secondary ... muscarinic agents such as pilocarpine, hyperosmotic agents such as mannitol and carbonic anhydrase inhibitors such as ... It is sometimes considered as a secondary inflammatory glaucoma. Ocular hypertension (IOP 30 - 70 mmHg) with open angle of ...

https://en.wikipedia.org/wiki/Posner–Schlossman_syndrome

... anti-epileptic and non-steroidal anti-inflammatory drugs; X-ray contrast agents; polycyclic musk fragrances; and ingredients of ... X-ray contrast agents, and ingredients of personal care products, can be broken down in a non-toxic way. Mycoremediation is a ...

https://en.wikipedia.org/wiki/Mycoremediation

"Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with ... Höglund OV, Dyall B, Gräsman V, Edner A, Olsson U, Höglund K (October 2018). "Effect of non-steroidal anti-inflammatory drugs ... Metacam is a prescription non-steroidal anti-inflammatory drug (NSAID) that is used to control pain and inflammation (soreness ... In Europe the product is licensed for other anti-inflammatory benefits including relief from both acute and chronic pain in ...

https://en.wikipedia.org/wiki/Meloxicam

Non-steroidal anti-inflammatory drugs (NSAIDs), preferably indometacin, are usually employed as pain control agents. A number ... The extract is thought to inhibit the same enzyme, cyclooxygenase-2 (COX-2), as the non-steroidal anti-inflammatory drugs. ... A couple of medications are used to relieve pleurisy symptoms: Paracetamol (acetaminophen) or anti-inflammatory agents to ... 1999). "Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice". Life Sci ...

https://en.wikipedia.org/wiki/Pleurisy

Treatment with non-steroidal anti-inflammatory agents or treatment of the underlying Hodgkin's (usually with chemotherapy) will ...

https://en.wikipedia.org/wiki/Pel–Ebstein_fever

Treatment is symptomatic and includes the administration of non-steroidal anti-inflammatory agents or the application of heat ...

https://en.wikipedia.org/wiki/Bornholm_disease

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most recurrently used classes of drug clinically, indicated for ... Chemotherapeutic agents are drugs that are used in chemotherapy for the treatment of cancer. Many of these agents are known to ... non-steroidal anti-inflammatory drugs (NSAIDs) and loop diuretics. While these drugs target on different body systems, they ... Vane, J. R.; Botting, R. M. (1998-12-03). "Anti-inflammatory drugs and their mechanism of action". Inflammation Research. 47: ...

https://en.wikipedia.org/wiki/Ototoxic_medication

Naproxen is a non-steroidal anti-inflammatory drug while cromolyn is an anti-allergic agent which acts as a mast cell ... Curcumin has wide pharmacological activities: anti-inflammatory, anti-microbial, hypoglycemic, anti-oxidant, and wound healing ... Curcumin's mechanism of action is anti-inflammatory; it inhibits the nuclear transcriptional activator kappa B (NF-KB) that is ... Kohli K, Ali J, Ansari MJ, Raheman Z (2005). "Curcumin: A natural antiinflammatory agent". Indian Journal of Pharmacology. 37 ( ...

https://en.wikipedia.org/wiki/GSK-3

... is not recommended to be taken with aspirin or non-salicylate NSAIDs (non-steroidal anti-inflammatory drugs), as it ... Apigenin, a phytochemical in chamomile, may interact with anticoagulant agents and nonsteroidal anti-inflammatory drugs, while ... Chamomile is under preliminary research for its potential anti-anxiety properties. There is no high-quality clinical evidence ... scentless or false chamomile Chamomile may be used as a flavoring agent in foods and beverages, mouthwash, soaps, or cosmetics ...

https://en.wikipedia.org/wiki/Chamomile

Naturally Occurring Non-steroidal Anti-inflammatory and Anti-oxidant Agent Derived from Extra Virgin Olive Oils". Organic ... Similar to classical non-steroidal anti-inflammatory drugs, it is a non-selective inhibitor of cyclooxygenase (COX). 50 g (more ... a natural anti-inflammatory agent in extra virgin olive oils". Chem Senses. 34 (4): 333-9. doi:10.1093/chemse/bjp006. PMC ... "Against this background, the in vivo anti-inflammatory effects of dietary oleocanthal cannot be as relevant as hypothesized by ...

https://en.wikipedia.org/wiki/Oleocanthal

A new synthesis of some non-steroidal anti-inflammatory agents with the 2-arylpropionic acid skeleton by the use of diphenyl ...

https://en.wikipedia.org/wiki/Diphenylphosphoryl_azide

... on the non-steroidal anti-inflammatory drug-induced exacerbation of gastric ulcer in rats". Japanese Journal of Pharmacology. ... Tanaka H, Shuto K, Marumo H (April 1982). "Effect of N-acetyl-L-glutamine aluminum complex (KW-110), an antiulcer agent, ... 35-. ISBN 978-0-8155-1856-3. Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and ... and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor ...

https://en.wikipedia.org/wiki/Aceglutamide

... non-steroidal anti-inflammatory drugs, cytotoxic agents (chlorambucil, cyclophosphamide), corticosteroid sparing ... 121(4):491-9, 2003 Narla LD et al: Inflammatory Pseudotumor. RadioGraphics. 23(3):719-729, 2003 Belanger C et al: Inflammatory ... Idiopathic orbital inflammatory (IOI) disease refers to a marginated mass-like enhancing soft tissue involving any area of the ... Idiopathic orbital inflammatory syndrome, also known as orbital pseudotumor, was first described by Gleason in 1903 and by ...

https://en.wikipedia.org/wiki/Idiopathic_orbital_inflammatory_disease

Options include pain medication (except ibuprofen and other 'non-steroidal anti-inflammatory agents (NSAID's)' which may worsen ...

https://en.wikipedia.org/wiki/Cystic_kidney_disease

... anion transporter 3/solute carrier family 22 member 8 so is likely to interact with non-steroidal anti-inflammatory agents and ...

https://en.wikipedia.org/wiki/Tafamidis

... other non-steroidal anti-inflammatory agents (NSAID) in humans. Synthetic BLT2 agonists may be useful for speeding the healing ... Opposition between the pro-inflammatory LTB4/BLT1 and anti-inflammatory actions of the 12-HHT/BLT2 axes occurs in another ... exerting an anti-inflammatory activity". Experimental & Molecular Medicine. 44 (6): 378-86. doi:10.3858/emm.2012.44.6.043. PMC ... and other agents. BLT2 may ultimately prove to have binding specificity for a similarly broad range of agents. The production ...

https://en.wikipedia.org/wiki/12-Hydroxyheptadecatrienoic_acid

... enzymes which metabolize 20-HETE such as non-steroidal anti-inflammatory agents, opioids, gemfibrozil, Lasix, propanol, and ... Many agents stimulate cells and tissues to produce 20-HETE in vitro and in vivo. Androgens are particularly potent stimulators ... There are a variety of pharmacological agents which inhibit the synthesis of 20-HETE including various fatty acid analogs that ... This metabolism-induced inactivation may underlie the proposed roles of the cytochromes in dampening inflammatory responses and ...

https://en.wikipedia.org/wiki/20-Hydroxyeicosatetraenoic_acid

Hirohata M, Ono K, Naiki H, Yamada M (December 2005). "Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects ... It increases cerebral blood flow and is an anti-inflammatory agent, enhancing activity at the neuronal synapses in the brain. ... Non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the risk of developing Alzheimer's and Parkinson's diseases. The ... Etminan M, Gill S, Samii A (July 2003). "Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: ...

https://en.wikipedia.org/wiki/Prevention_of_dementia

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin production by PTGS1 (COX-1) and PTGS2 (COX-2). NSAIDs ... The lipoxins and epi-lipoxins are potent anti-inflammatory agents and may contribute to the overall activities of the two COX's ... Tikhonovich, Marina V.; Erdiakov, Aleksei K.; Gavrilova, Svetlana A. (2017-06-21). "Nonsteroid anti-inflammatory therapy ... PTGS2 is linked with the inflammatory system and has been observed in inflammatory leukocytes. It has been noted that there is ...

https://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase_2

... of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs)". Archives of Biochemistry and ... inhibitors of target enzymes and potent antagonists of target receptors for eventually leading to useful therapeutic agents. He ... He obtained his Ph.D. degree in the mid-1970s working on the crystal structure determinations and design of anti-inflammatory ...

https://en.wikipedia.org/wiki/Tej_P._Singh

Angiotensin-converting enzyme (ACE) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) are also drugs associated ... Calcimimetic agents may be necessary, e.g. Cinacalcet.[citation needed] In mild cases of milk-alkali syndrome, full recovery is ... For mild cases of MAS, the only intervention needed is to withdraw the offending agent. By having the person stop taking any ... as well as how to reverse the syndrome by discontinuing the offending agent and seeking medical attention. ...

https://en.wikipedia.org/wiki/Milk-alkali_syndrome

This was shown when the anti-hyperalgesic action was reduced when administered in α2 and α3 mice in inflammatory pain and in ... In a rat brain slice preparation, the synthetic steroidal anesthetic alphaxalone (5α-pregnan-3α-ol-11,20 dione) enhanced both ... Sedative actions of benzodiazepines limit their usefulness as analgesic agents and they are therefore generally not considered ... Additionally, studies in α5 mice showed that the spinal α5-containing GABAA receptor has a minor role in inflammatory pain. An ...

https://en.wikipedia.org/wiki/GABAA_receptor_positive_allosteric_modulator

Non-steroidal anti-inflammatory drug (NSAID) residues risk causing rare, but potentially fatal side-effects in humans. There is ... Many chemical agents used for animal euthanasia leave residues in the meat which may be harmful to humans, and have caused ... A non-steroidal anti-inflammatory drug (NSAID) commonly used for the treatment of musculoskeletal disorders in horses. ...

https://en.wikipedia.org/wiki/2013_horse_meat_scandal

Antipsychotic drugs Anticonvulsants Non-steroidal anti-inflammatory drugs (e.g. Antihistamine) Opioid Medical marijuana ... Vallejos, Ximena; Wu, Christine (2017-04-01). "Flibanserin: A Novel, Nonhormonal Agent for the Treatment of Hypoactive Sexual ... Steroidal anti-androgens are a class of steroid drugs that inhibit the actions of androgens. Cyproterone acetate, a 17- ... and steroidal anti-androgens. GnRH agonists are a group of drugs intended to activate GnRH receptors in the anterior pituitary ...

https://en.wikipedia.org/wiki/Drugs_and_sexual_desire

"Assessment report for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and cardiovascular risk" (PDF). European Medicines Agency ... oral anti-diabetics, colestyramine, dextromethorphan, mifepristone, corticosteroids, anti-platelet agents and selective ... Tenoxicam, sold under the brand name Mobiflex among others, is a nonsteroidal anti-inflammatory drug (NSAID). It is used to ... or other allergic reactions caused by Aspirin or other nonsteroidal anti-inflammatory drugs (for example diclofenac, ibuprofen ...

https://en.wikipedia.org/wiki/Tenoxicam

The main COX inhibitors are the non-steroidal anti-inflammatory drugs. The classical COX inhibitors are not selective and ... "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents". Nature. 384 (6610): 644-8. Bibcode: ... These acids can be turned into some anti-inflammatory prostacyclins by COX instead of pro-inflammatory prostaglandins. ... "Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of ...

https://en.wikipedia.org/wiki/Cyclooxygenase

These include β2-agonists, dopamine, insulin, allopurinol, and non-steroidal anti-inflammatory drugs (NSAIDs), such as ... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ... These agents are less likely to produce early warning signs (phosgene in low concentrations has a pleasant odor), are more ...

https://en.wikipedia.org/wiki/Acute_inhalation_injury

Anastomosis tension Gastric acid The bacteria Helicobacter pylori Smoking Use of non-steroidal anti-inflammatory drugs This ... condition can be treated with: Proton pump inhibitors, e.g. esomeprazole A cytoprotectant and acid buffering agent, e.g. ...

https://en.wikipedia.org/wiki/Gastric_bypass_surgery

... anti-inflammatory agents MeSH D27.505.954.158.030 - anti-inflammatory agents, non-steroidal MeSH D27.505.954.158.030.500 - ... anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122.085 - anti-bacterial agents MeSH D27.505 ... antirheumatic agents MeSH D27.505.954.329.030 - anti-inflammatory agents, non-steroidal MeSH D27.505.954.329.337 - gout ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D27)

Anti-inflammatory agents, Immunosuppressants, Selective glucocorticoid receptor modulators). ... Selective glucocorticoid receptor agonists (SEGRAs) are historically and typically steroidal in structure while selective ... and a number of other pro-inflammatory proteins. Hence the anti-inflammatory effects of glucocorticoids results from both ... Hence, these mice were responsive to the anti-inflammatory effects of dexamethasone but were resistant to at least some of the ...

https://en.wikipedia.org/wiki/Selective_glucocorticoid_receptor_modulator

Strictly speaking, and also historically, the wider class of anti-inflammatory drugs also comprises steroidal anti-inflammatory ... and not all drugs used to treat atherosclerosis are triglyceride-lowering agents. A drug class is typically defined by a ... The drug class of "nonsteroidal anti-inflammatory drugs" (NSAIDs) is thus composed by one element ("anti-inflammatory") that ... "anti-rheumatic drug") that indicates its therapeutic use. Nonsteroidal anti-inflammatory drug (NSAID) Disease-modifying ...

https://en.wikipedia.org/wiki/Drug_class

... some doctors recommend the use of non-steroidal anti-inflammatory drugs (NSAIDs) or child-safe pain-relief treatments ... Teething gels work as a numbing agent to dull the nerves in the gums so that the pain is less noticeable. It is important to ... "The symptoms of elevated temperature and facial rash could be explainable by infection with the HHV-6 agent, which is ... the risks and adverse effects from inappropriate or prolonged use of pharmacological agents outweigh their potential benefits ...

https://en.wikipedia.org/wiki/Teething

"Modern Non-Steroidal Anti-Inflammatory Drug and Interferon Inductor Amizon: Prospects of Application" (PDF). Institute of ... Antimicrobial Agents and Chemotherapy. 65 (4). doi:10.1128/AAC.02605-20. PMC 8097484. PMID 33558285. РІШЕННЯ [Decision]. ДСІВУ ...

https://en.wikipedia.org/wiki/Enisamium_iodide

Bofill Rodriguez, M; Lethaby, A; Farquhar, C (19 September 2019). "Non-steroidal anti-inflammatory drugs for heavy menstrual ... line Intrauterine device with progesterone Second Line Tranexamic acid an antifibrinolytic agent Nonsteroidal anti-inflammatory ... appear to be more effective than anti-inflammatory treatment like NSAIDs, but are less effective than LNG-IUS. Tranexamic acid ... Pelvic inflammatory disease Adenomyosis - extension of the endometrial tissue into the outer muscular wall of the uterus which ...

https://en.wikipedia.org/wiki/Heavy_menstrual_bleeding

Commercially, pseudopterosins are found in skin creams as topical anti-inflammatory agents. Elisabethatriene (2) has been ... with a mechanism of action different from the common non-steroidal anti-inflammatory drugs, NSAIDs. ... The proposed synthesis of artificial anti-inflammatory metabolites is modeled after pseudopterosins and is based on the ... Pseudopterosins have anti-inflammatory and analgesic activity, ...

https://en.wikipedia.org/wiki/Pseudopterosin_A

... and non-steroidal anti-inflammatory drugs (NSAIDs). Bile acid diarrhea is found in 41% of patients with collagenous colitis and ... Studies of a number of other agents including antidiarrheals, bismuth subsalicylate (Pepto-Bismol), mesalazine/mesalamine ( ... Inflammatory cells are increased both in the surface epithelium ("intraepithelial lymphocytes") and in the lamina propria. The ... Anti-TNF inhibitors. split ileostomy, diverting ileostomy, and subtotal colectomy are options for management of steroid- ...

https://en.wikipedia.org/wiki/Microscopic_colitis

... pylori even prevents bleeding from ulcers that is caused by aspirin and non-steroidal anti-inflammatory drugs. 2002 The ... A study is published in China about the effectiveness of treating PUD with an antibacterial agent. July 31: The New York Times ... Bismuth is an antibacterial agent, although this is not recognized by Ramsey. J. Robin Warren first observes H. pylori in a ... 1972 The first report of successfully using furazolidone (an antibacterial agent) to treat PUD in China. 1974 Morozov observes ...

https://en.wikipedia.org/wiki/Timeline_of_peptic_ulcer_disease_and_Helicobacter_pylori

... a new non-steroidal analgesic anti-inflammatory drug]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). ... Anti-inflammatory agents). ... is a nonsteroidal anti-inflammatory drug (NSAID) used for its ... analgesic and anti-inflammatory actions. It is often prescribed for rheumatoid arthritis, lower back pain, frozen shoulder, and ... 2017). "Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo ...

https://en.wikipedia.org/wiki/Mofezolac

Biedermann T, Hartmann K, Sing A, Przybilla B (2002). "Hypersensitivity to non-steroidal anti-inflammatory drugs and chronic ... Gonçalves AQ, Viana Jda C, Pires EM, Bóia MN, Coura JR, Silva EF (2007). "The use of the antifungal agent miconazole as an ... Carbarsone was available as an anti-infective compound in the United States as late as 1991, and was suggested as a possible ... One study investigated the subtypes found in patients with irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), ...

https://en.wikipedia.org/wiki/Blastocystosis

Chemical agents involved in the defense systems of these organisms often exhibit antibacterial, anti-inflammatory, and ... Unlike many non-steroidal anti-inflammatory drugs, Δ9,12-capnellene-8β,10α-diol is advantageous in its selectivity for the COX ... anti-inflammatory and anti-tumor properties. Δ9(12)-capnellene, also referred to simply as capnellene in the literature, is a ... Capnella imbricata is a rich source of many non-isoprenoid sesquiterpenes, which all share the cis,anti,cis-tricyclo[6.3.0.02,6 ...

https://en.wikipedia.org/wiki/Capnellene

... a particularly toxic non-steroidal anti-inflammatory drug with analgesic as well as antipyretic properties that had been ... a chronic nerve damage syndrome similar to that caused by certain nerve agents. Unwary imbibers suffered a form of paralysis ...

https://en.wikipedia.org/wiki/Patent_medicine

... or nonsteroidal anti-inflammatory drugs), a potassium level should be checked after two weeks of use to test for hyperkalemia. ... is a synthetic steroidal 17α-spirolactone, or more simply a spirolactone. It is an analogue of other spirolactones like ... oil-based drospirenone microcrystal suspensions-evaluation of physicochemical stability and influence of stabilising agents". ... and nonsteroidal anti-inflammatory drugs to further increase potassium levels. This may increase the risk of hyperkalemia (high ...

https://en.wikipedia.org/wiki/Drospirenone

Since many cases of toothache are inflammatory in nature, over the counter non-steroidal anti-inflammatory drugs (NSAIDs) may ... such as the sedative agent used and whether a rubber dam was used. The success rate of root canal treatment also depends on the ... As the pocket deepens, the balance is disrupted, and an acute inflammatory response results, forming pus. The debris and ... such as inflammatory mediators).: 532-534 The pain pathway is mostly transmitted via myelinated Aδ (sharp or stabbing pain) and ...

https://en.wikipedia.org/wiki/Toothache

McGettigan, Patricia; Henry, David (2011-09-27). "Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic ... Rofecoxib is a selective COX-2 inhibitor, or "coxib". Though the class of coxibs includes several agents, there are varying ... compared to patients on the comparator non-steroidal anti-inflammatory drug (NSAID), Naprosyn (naproxen)." This led to the ... "Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant ...

https://en.wikipedia.org/wiki/Rofecoxib

Cundiff DK, Manyemba J, Pezzullo JC (January 2006). Cundiff DK (ed.). "Anticoagulants versus non-steroidal anti-inflammatories ... Chronic inflammatory diseases and some autoimmune diseases, such as inflammatory bowel disease, systemic sclerosis, Behçet's ... which involves injecting a peripheral vein of the affected limb with a contrast agent and taking X-rays, to reveal whether the ... Risk factors include recent surgery, older age, active cancer, obesity, infection, inflammatory diseases, antiphospholipid ...

https://en.wikipedia.org/wiki/Deep_vein_thrombosis

Non-steroidal anti-inflammatory drugs such as aspirin or ibuprofen have been proposed as a treatment for the headaches ... Agents and Actions. 4 (2): 125-30. doi:10.1007/BF01966822. PMID 4842541. S2CID 5924137. Korsten MA, Matsuzaki S, Feinman L, ... "Anti-Hangover Tips". The Webtender. Retrieved 26 March 2010. McGregor NR (November 2007). "Pueraria lobata (Kudzu root) ...

https://en.wikipedia.org/wiki/Hangover

Concern over the scale of morbidity associated with the use of oral non-steroidal anti-inflammatory drugs (NSAIDs), ... Anti-Inflammatory Agents, Non-Steroidal / administration & dosage* * Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics ... Transdermal non-steroidal anti-inflammatory agents Br J Clin Pract. 1995 Jan-Feb;49(1):33-5. ... Concern over the scale of morbidity associated with the use of oral non-steroidal anti-inflammatory drugs (NSAIDs), ...

https://pubmed.ncbi.nlm.nih.gov/7742182/?dopt=Abstract

2 Abstracts with Anti-Inflammatory Agents: Non-Steroidal Research. Filter by Study Type. Animal Study. ... Pharmacological Actions : Analgesics, Anti-Inflammatory Agents: Non-Steroidal. Additional Keywords : Natural Substances Versus ... 2 Substances Researched for Anti-Inflammatory Agents: Non-Steroidal Name. AC. CK. Focus. ... Researchers have declared that tart cherries have the "highest anti-inflammatory content of any food." They can help you manage ...

https://greenmedinfo.com/pharmacological-action/anti-inflammatory-agents-non-steroidal

Aspirin, NSAIDs, and anti-thrombotics. Aspirin and nonsteroidal anti-inflammatory agents (NSAIDs) are very common causes of ... Non-steroidal Anti-inflammatory Drug. Aspirin (Acetylsalicylic acid, ASA, Bayer Advanced Aspirin). *View full drug information ... Prokinetic Agents. Class Summary. The use of the prokinetics agent to empty the stomach of retained blood or clots to improve ... FDA labeling of NSAIDs: Review of nonsteroidal anti-inflammatory drugs in cardiovascular disease. Trends Cardiovasc Med. 2016 ...

https://www.medscape.com/answers/187857-194437/which-medications-in-the-drug-class-proton-pump-inhibitors-are-used-in-the-treatment-of-upper-gastrointestinal-bleeding-ugib

Trends and demographic patterns in biologic and corticosteroid prescriptions for inflammatory bowel disease: findings from ...

https://jim.bmj.com/keyword/anti-inflammatory-agents-non-steroidal

Results of search for su:{Anti-inflammatory agents, Non-steroidal} Refine your search. *. Availability. * Limit to currently ... Non-steroidal anti-inflammatory drugs : views and expert opinions of an IARC Working Group on the Evaluation of Cancer ... by IARC Working Group on the Evaluation of Cancer Preventive Agents (1997) Lyon, France , International Agency for Research on ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BAnti-inflammatory%20agents%2C%20Non-steroidal%7D

7.1 Nephrotoxic Agents, Including Non-Steroidal Anti-Inflammatory Drugs. The concurrent use of mesalamine with known ... nephrotoxic agents, including nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of nephrotoxicity. Monitor ... The mechanism of action of mesalamine is not fully understood, but appears to be a topical anti-inflammatory effect on colonic ... releasing mesalamine for topical anti-inflammatory action in the colon. Mesalamine (also referred to as 5-aminosalicylic acid ...

https://www.drugs.com/pro/zaldyon.html

https://www.staging.medscape.com/answers/187857-194434/which-medications-in-the-drug-class-non-steroidal-anti-inflammatory-drug-are-used-in-the-treatment-of-upper-gastrointestinal-bleeding-ugib

Effect of some non-steroidal anti-inflammatory agents on blood sugar level and on insulin-induced hypoglycaemia in albino rats. ... Effect of some non-steroidal anti-inflammatory agents on blood sugar level and on insulin-induced hypoglycaemia in albino rats ...

https://imsear.searo.who.int/handle/123456789/108424

7.1 Agents Increasing Serum Potassium 7.2 Lithium 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase ... 7.3 Non-Steroidal Anti-Inflammatory Agents Including Selective Cyclooxygenase-2 Inhibitors. Losartan Potassium In patients who ... The administration of a non-steroidal anti-inflammatory agent including a selective COX-2 inhibitor can reduce the diuretic, ... Therefore, when losartan potassium and hydrochlorothiazide and non-steroidal anti-inflammatory agents including selective COX-2 ...

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=4458c120-3064-2f39-e054-00144ff8d46c&type=display

... riot control agents, and lachrymators, is to produce immediate discomfort and eye closure to render the victim incapable of ... Nonsteroidal anti-inflammatory agents (NSAIDs). Class Summary. NSAIDs have analgesic, anti-inflammatory, and antipyretic ... Respiratory agents: irritant gases, riot control agents, incapacitants, and caustics. Crit Care Clin. 2005 Oct. 21(4):719-37, ... encoded search term (Irritants - Riot Control Agents) and Irritants - Riot Control Agents What to Read Next on Medscape ...

https://emedicine.medscape.com/article/833315-medication

Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: Novel non-steroidal anti-inflammatory agents with ... at the 6th position of the fused ring have been evaluated as potential analgesic/anti-inflammatory agents without a ... In an effort to establish new candidates with improved analgesic and anti-inflammatory activities and lower ulcerogenic risk, a ... All compounds were evaluated for their in vivo anti-inflammatory and analgesic activities in mice. Furthermore, the ulcerogenic ...

https://avesis.hacettepe.edu.tr/yayin/0fb4203e-3ad3-4b8d-bc36-19beda2ca59a/thiazolo3-2-b-1-2-4-triazole-56h-one-substituted-with-ibuprofen-novel-non-steroidal-anti-inflammatory-agents-with-favorable-gastrointestinal-tolerance

Anti-Inflammatory Agents. Antirheumatic Agents. Anti-Inflammatory Agents, Non-Steroidal. Analgesics, Non-Narcotic. Analgesics. ... Sensory System Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Gastrointestinal Agents. ...

https://clinicaltrials.gov/ct2/show/NCT03915964

Anti-Inflammatory Agents, Non-Steroidal. en. dc.subject.mesh. Clozapine. en. dc.subject.mesh. Angiotensin-Converting Enzyme ...

https://extranet.who.int/iris/restricted/handle/10665/57619?show=full

... have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical ... Non-steroidal anti-inflammatory agents in the management of Colles fractures. The British journal of clinical practice. 1988; ... Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are ... "anti-inflammatory agents" "non-steroidal", "bone", and "animals" (the complete search strategy is provided in supplementary ...

https://www.researchsquare.com/article/rs-50680/v1

Anti-Inflammatory Agent, Non-Steroidal; Cyclooxygenase Inhibitor; Metabolite; Platelet Aggregation Inhibitor; Salicylate; ... A non-steroidal anti-inflammat ory drug with cyclooxygenase inhibitor activity. ChEBI CHEBI:15365. ... Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an anti-inflammatory compound ... Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an anti-inflammatory compound ...

http://www.chemspider.com/Chemical-Structure.2157.html?rid=74f710ba-367d-4ddd-b759-5d0da1548079&page_num=0

A non-steroidal anti-inflammatory, cell permeable, antipyretic agent.. View Price and Availability. ...

https://www.sigmaaldrich.com/GB/en/product/sigma/i7378

Anti-Inflammatory Agents, Non-Steroidal. Orner GA, Dashwood W-M, Blum CA, G Díaz D, Li Q, Dashwood RH. 2003. Suppression of ...

https://lpi.oregonstate.edu/biblio?f%5Bauthor%5D=6231&o=asc&page=1&s=keyword

... non-steroidal anti-inflammatory agent Substances 0.000 description 7 * 229940021182 non-steroidal anti-inflammatory drugs Drugs ... 239000002260 anti-inflammatory agent Substances 0.000 description 4 * 229940121363 anti-inflammatory agents Drugs 0.000 ... 239000003755 preservative agent Substances 0.000 description 3 * 239000007940 sugar coated tablet Substances 0.000 description ... 239000006172 buffering agent Substances 0.000 claims description 13 * BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class ...

https://patents.google.com/patent/EP1890680B1/en

Chemopreventive agents inhibit the development of cancer either by impeding DNA damage, which leads to malignancy or by ... The success of using chemopreventive agents for protecting the high risk populations from cancer indicates that the strategy is ... In this review, we have addressed the mechanism of chemopreventive and anticancer effects of several natural agents. ... piperlongumine have demonstrated inhibitory effects on cancer cells indicating that they may serve as chemopreventive agents. ...

https://www.mdpi.com/1422-0067/20/20/4981

Dosage testing and comparison with an non-steroidal anti-inflammatory agent. Ann Cardiol Angeiol 1994; 43: 160-166 ... Non-steroidal anti-inflammatory drugs reduce the risk of an extension of SVT or its recurrence and they reduce pain. A surgical ... A pilot randomized double-blind comparison of a low-molecular-weight heparin, a nonsteroidal anti-inflammatory agent, and ... comparison of low-molecular-weight-heparin and combined therapy of low-molecular-weight heparin with an anti-inflammatory agent ...

https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1238-6645

Non-Steroidal Anti-Inflammatory Agents (NSAIDs) 6. Messenger RNA (mRNA) 7. Nitric Oxide Synthase (NO Synthase) ... Bio-Agent Context: Research Results. *Amino Acids, Peptides, and Proteins*Proteins: 90489*Protein Isoforms: 9625*Isoenzymes: ... 01/01/2014 - "The inhibitory effect of CHQ on SERCA isoforms may be beneficial in therapeutic approaches aimed at anti-tumor ...

https://www.curehunter.com/public/keywordSummaryD020033.do

The risk, however, is halved compared with conventional non-steroidal anti-inflammatory agents (NSAIAs). Case reports suggest ... Where there is a clear need for an anti-inflammatory agent, they may be prescribed cautiously for patients with a history of ... Medicines Control Agency (MCA)/Committee on Safety of Medicines (CSM). Non-steroidal anti-inflammatory drugs (NSAIDs) and ... Risk of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994; 343:1075-1078. ...

https://www.medsafe.govt.nz/profs/PUarticles/COX2GI.htm

A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium ... Info Anti-Inflammatory Agents. * Info Anti-Inflammatory Agents, Non-Steroidal. * Info Antirheumatic Agents ...

https://druginfo.nlm.nih.gov/drugportal/name/Diclofenac

... systemic agents, laser and photodynamic therapy, and cryosurgery. ... These can be broadly categorized as topical agents, dressings, ... Anti-inflammatory agents (e.g. corticosteroids and non- ... steroidal lotion, gels, creams and lotions) to reduce inflammation. *Antipruritic agents (e.g. antihistamines and local ... Topical Agents. Topical agents are the most commonly used type of therapy used by dermatologists. They may be delivered in ...

https://www.news-medical.net/health/Dermatologic-Therapy.aspx

Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms ... Anti-inflammatory agents included: non-steroidal anti-inflammatory drugs (NSAIDs); omega 3 fatty acids; drugs that curb ... Anti-inflammatory agents can effectively and safely curb major depressive symptoms. October 28, 2019. Anti-inflammatory agents ... But anti inflammatory agents didnt seem to improve quality of life, although this might have been because of the small number ...

https://www.brightsurf.com/news/article/102819495527/anti-inflammatory-agents-can-effectively-and-safely-curb-major-depressive-symptoms.html

Non-steroidal anti-inflammatory drug, NSAIDIndications:Joint syndrome : rheumatoid arthritis, arthritis, ancylosing spondilit, ... This is an analgesic, antipyretic and anti-inflammatory agent. Non-steroidal anti-inflammatory drug, NSAID. Indications:. Joint ...

https://www.newlondonpharmacy.com/products/niflugel-niflumic-acid-2-5

Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs ... for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for ...

https://patentscope.wipo.int/search/en/detail.jsf?docId=PH218128437

Non-Steroidal Anti-Inflammatory Agents 10% * Local Anesthetics 10% 8 Downloads (Pure) ... Similar Effects of Exercise Therapy, Nonsteroidal Anti-inflammatory Drugs, and Opioids for Knee Osteoarthritis Pain: A ...

https://portal.findresearcher.sdu.dk/en/persons/jthorlund/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle

... treatment with a non-steroidal anti-inflammatory agent within the previous 2 days; treatment with aspirin within 14 days prior ... None of the patients received any antifibrinolytic agent prior to surgery.. Management of anesthesia. The following ... This is because APTEM is useful when predicting the effects of antifibrinolytic agents on hyperfibrinolysis [41]. Moreover, ... Furthermore, the effects of antifibrinolytic agents on systemic hemostasis must be investigated in viscoelastic studies. ...

https://medsci.org/v15p0788.htm

Concern over the scale of morbidity associated with the use of oral non-steroidal anti-inflammatory drugs (NSAIDs), particularly in the elderly, has led to the development of alternative strategies for the relief of musculoskeletal and joint pain. (nih.gov)
NSAIDs have analgesic, anti-inflammatory, and antipyretic activities. (medscape.com)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): increased risk of renal impairment and reduced diuretic, natriuretic, and antihypertensive effects. (nih.gov)
or exp Analgesics/) OR (NSAIDS.mp or exp Anti-Inflammatory Agents, Non-Steroidal/) OR (anti-inflammatory agents, non-steroidal.mp. (bestbets.org)
There are three general classes of drugs commonly used in the treatment of rheumatoid arthritis: non-steroidal anti-inflammatory agents (NSAIDs), corticosteroids, and disease modifying anti-rheumatic drugs (DMARDs). (hopkinsarthritis.org)
Aspirin is the oldest drug of the non-steroidal class, but because of its high rate of GI toxicity, a narrow window between toxic and anti-inflammatory serum levels, and the inconvenience of multiple daily doses, aspirin's use as the initial choice of drug therapy has largely been replaced by other NSAIDs. (hopkinsarthritis.org)
Nephrotoxic agents, including non-steroidal anti-inflammatory drugs (NSAIDs): May increase the risk of renal reactions. (pediatriconcall.com)
Substantial evidence indicates that aspirin and related non-steroidal anti-inflammatory drugs (NSAIDs) have potential as chemopreventative/therapeutic agents. (spandidos-publications.com)
Abundant evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, are anti-tumorigenic and can prevent CRC ( 2 - 6 and refs. (spandidos-publications.com)
In addition, we examined associations between neuropathy at baseline and use of specific classes of antihypertensive medications and non-steroidal anti-inflammatory agents (NSAIDs) in year 3. (jabfm.org)
Non-steroidal anti-inflammatory agents (NSAIDs) like ibuprofen or naproxen and pain relievers such as acetaminophen may also help. (handandwristinstitute.com)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are useful for preventing and relieving pain. (bvsalud.org)
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been prescribed extensively throughout the world. (medscape.com)
Antimicrobial agents were the most commonly prescribed followed by NSAIDs/analgesics. (who.int)
Nonsteroidal anti-inflammatory drugs (NSAIDs) have often been administered to decrease the incidence of inflammatory complications, especially pain, caused by surgical extraction of third molars. (bvsalud.org)
Mild cases of RP are usually treated with non-steroidal anti-inflammatory drugs (NSAIDs) or low doses of systemic corticosteroids. (medscape.com)
Gastrointestinal (GI) intolerance of non-steroidal anti-inflammatory drugs (NSAIDs), lactose intolerance and simply not liking something are not allergies. (patient.info)
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. (nih.gov)
Treatment usually consists of rest, non-steroidal anti-inflammatory drugs (NSAIDs), ice, stretching, strengthening and progressive return to function or sport. (goldenhillspt.com)

Non-steroidal anti-inflammatory drugs : views and expert opinions of an IARC Working Group on the Evaluation of Cancer Preventive Agents, Lyon, 2-8 April 1997. (who.int)
Background: Non-steroidal anti-inflammatory drugs (NSAID) have excellent anti-inflammatory and analgesic properties and are extensively used to treat post-traumatic or surgical musculoskeletal pain. (researchsquare.com)
Non-steroidal anti-inflammatory drugs (NSAID) have been extensively used to treat post-traumatic and surgical musculoskeletal pain because of the excellent anti-inflammatory and analgesic properties of cyclooxygenase (COX) inhibitors (1-5). (researchsquare.com)
All of these drugs also have mild to moderate analgesic properties independent of their anti-inflammatory effect. (hopkinsarthritis.org)
Intriguingly, the authors found that a variety of anti-inflammatory agents, including steroidal and non-steroidal anti-inflammatory drugs, increased waking activity during the day. (harvard.edu)
The purpose of this pilot study was to evaluate the effectiveness of two COX-2 selective non-steroidal anti-inflammatory drugs on pain control after open flap debridement. (bvsalud.org)
Anti-inflammatory experiments were performed using non-steroidal anti-inflammatory drugs as reference drugs. (vietketnoi.net)
Non-steroidal anti-inflammatory drugs have been used as they are non-biological anti-inflammatory drugs. (vietketnoi.net)
Nonsteroidal anti-inflammatory drugs have been reported to suppress inflammation induced by various agents in experimental animal models. (vietketnoi.net)
Nonsteroidal anti-inflammatory drugs are commonly used in the treatment or management of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis and for its anti-inflammatory and analgesic effects. (vietketnoi.net)
Nonsteroidal anti-inflammatory drugs work to reduce inflammation, swelling, and pain in joints by inhibiting synthesis. (vietketnoi.net)
In this volume on non-steroidal anti-inflammatory drugs the following drugs are reviewed: Aspirin, Sulindac, Piroxicam and Indomethacin. (who.int)
These include interventions for primary prevention with pharmacological or immunological agents, foods, and behaviour changes (e.g. non-steroidal anti-inflammatory drugs, vitamin D, and increased physical activity), as well as interventions for secondary prevention (e.g. screening for cancers of the cervix, breast, or colorectum). (who.int)
Severe RP may require high-dose systemic corticosteroids, perhaps along with disease-modifying antirheumatic drugs (DMARDs) as steroid-sparing agents or for more severe disease. (medscape.com)
Participants were treated with either 2 mg or 4 mg of Oluminant each day or a placebo, plus conventional therapies including DMARDs, non-steroidal anti-inflammatory drugs, and 10 mg prednisone or less per day and directly compared. (thearthritisconnection.com)
The worst part was not getting any meaningful answers, I was given a cocktail of pain medications and steroidal anti-inflammatory drugs. (blessedjourneyherbals.com)
Kenacort is an anti-inflammatory corticosteroid drugs that is an inverse agonist at all the histamine H1 receptor. (canadadrugsinc.com)
Colorectal Cancer Survivors' Receptivity toward Genomic Testing and Targeted Use of Non-Steroidal Anti-Inflammatory Drugs to Prevent Cancer Recurrence. (cdc.gov)
A clinical diagnosis of acute herpes zoster on the left ophthalmic branch of the trigeminal nerve was confirmed by a dermatologist, and the patient was treated with acyclovir (400 mg, five times a day) and non-steroidal anti-inflammatory drugs for 1 week. (springeropen.com)

A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. (nih.gov)
Cannabis also acts as a powerful anti-inflammatory without NSAID side effects. (420magazine.com)
In addition, a non-steroidal anti-inflammatory drug (NSAID) or a narcotic may be given to relieve pain and inflammation. (vcahospitals.com)
Diclofenac is a potent Non-Steroidal Anti-Inflammatory Drug (NSAID) with marked analgesic and antipyretic properties. (inceptapharma.com)
All patients who are receiving long-term treatment with NSAID agents should be monitored as a precautionary measure (e.g., renal, hepatic function and blood counts).If abnormal liver function tests persist or worsen, clinical signs and symptoms consistent with liver disease develop or if other manifestations occur, Diclofenac sodium should be discontinued. (inceptapharma.com)

Acts as an analgesic, antipyretic, and anti-inflammatory agent. (medscape.com)
A non-steroidal anti-inflammatory, cell permeable, antipyretic agent. (sigmaaldrich.com)
In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. (bvsalud.org)

Different techniques have been suggested to manage immediate inflammatory response associated with impacted third molar surgery, include closing the surgical site with or without the use of a drain, use of physical therapy methods such as cryotherapy and bandage therapy and the use of medications such as analgesics, corticosteroids and antibiotics [7-10]. (bvsalud.org)

Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a pooled analysis of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry . (brightsurf.com)
They also identify a potential mechanism of action of these agents and shed light on the chemical structures that may be important for the antitumour effects of aspirin. (spandidos-publications.com)

Group E animals received a nonsteroidal anti-inflammatory drug (diclofenac) as a reference drug 100 mg/kg. (vietketnoi.net)

In an effort to establish new candidates with improved analgesic and anti-inflammatory activities and lower ulcerogenic risk, a series of thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one derivatives of ibuprofen were synthesized. (hacettepe.edu.tr)

An emerging body of evidence suggests that inflammation contributes to the development of major depression, but the results of clinical trials using various anti-inflammatory agents to treat the condition have proved inconclusive. (brightsurf.com)
The major effect of these agents is to reduce acute inflammation thereby decreasing pain and improving function. (hopkinsarthritis.org)
Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase and lipoxygenase pathways, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalamine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon. (pediatriconcall.com)
In this review, we revisit the literature on surgical stress, and outline the mechanisms by which surgical stress, including ischemia/reperfusion injury, activation of sympathetic nervous system, inflammation, systemically hypercoagulable state, immune suppression and effects of anesthetic agents, promotes tumor metastasis. (biomedcentral.com)
Cyclooxygenase-2 (COX-2) is induced during the inflammatory response and produces prostaglandins that mediate pain and inflammation. (medscape.com)
In an effort to find new herbal sources for the treatment of inflammation, current studies in ivy have been tested for its anti-inflammatory properties using 2% formalin to induce inflammation. (vietketnoi.net)
Septic arthritis occurs when bacteria or another infectious agent is introduced into one (or more) joints, leading to painful inflammation. (vcahospitals.com)

Case reports suggest that COX-2 inhibitors, like NSAIAs, may exacerbate inflammatory bowel disease and cause intestinal strictures. (medsafe.govt.nz)
Ulcerative colitis (inflammatory bowel disease). (pediatriconcall.com)

The drug may be used with MTX or other DMARDs but should not be combined with other JAK inhibitors or biologic agents. (thearthritisconnection.com)

COX-2 responds to tissue trauma and produces prostaglandins involved in the inflammatory response and pain mediation 5 . (bvsalud.org)

The injection form of the drug is very helpful for the treatment of pain and stiffness in a range of inflammatory condition, the drug is injected for rheumatoid arthritis, osteoarthritis and acute gouty arthritis. (canadadrugsinc.com)

or exp Cyclooxygenase Inhibitors/) OR (anti-inflammatory agents.mp. (bestbets.org)

Analgesia includes non-steroidal anti-inflammatory agents which help in reducing pain. (physio-pedia.com)

Pain can be of excruciating severity and may require both non-steroidal anti-inflammatory agents and major narcotics of the opiate class. (420magazine.com)
Cannabis does not cure Sickle Cell but is a highly effective agent in managing pain. (420magazine.com)
Cervical radiculopathy can be treated with anti-inflammatories as well as pain relievers. (handandwristinstitute.com)
14 and 3 had pain aggravated by hunger and the use of non steroidal anti-inflammatory agents. (bvsalud.org)
This type of surgery inflicts traumas to the highly vascularized region of the impaction, leading to inflammatory complications, also referred to as 'sequelae', because they are common occurrences and include pain, swelling and trismus [3]. (bvsalud.org)
These agents bind with opioid receptor sites in the dorsal horn of the spinal cord, resulting in modulation of pain signals at the spinal cord level. (medscape.com)
Other options include natural anti-inflammatories, immune modulating herbs, and non-narcotic pharmaceutical medications, as well as non-steroidal pain treatment injections. (andersonnaturalmedicine.net)
It is probably more common than tendinitis because often times tendon pain is not accompanied by the classic inflammatory signs of swelling, redness, and warmth. (goldenhillspt.com)
Click to view Terramycin Plus detailed prescribing information Antihistamine creams, which can also be called anti-itch creams, are used to relieve pain and itching due to insect bites, minor cuts and burns, and resolve rashes due to an allergy or plants such. (pridemenj.com)

Nevertheless, they conclude: "The results of this systematic review suggest that anti-inflammatory agents play an antidepressant role in patients with major depressive disorder and are reasonably safe. (brightsurf.com)
We present four clinical reports that illustrate the clinical uses of GMA with the medical device Adacolumn ® in patients with different backgrounds and immune-mediated inflammatory arthritis. (drugsincontext.com)
Filgotinib was further evaluated between July 2016 and June 2018 at 114 locations around the world in patients with moderately to severely active RA resistant to previous therapy with biologic agents and found to be very effective at controlling the disease according to the results of a clinical trial published in the July 23/30 issue of the Journal of the American Medical Association . (thearthritisconnection.com)
Vitamin D possesses anti-inflammatory and immunomodulatory effects in patients with breast cancer, and the mechanism of action of vitamin D in patients with breast cancer is discussed' - See vitamin D at Amazon.com . (qualitycounts.com)

These agents suppress gastric acid secretion by specifically inhibiting the H+/K+/ATPase enzyme system at the secretory surface of gastric parietal cells. (medscape.com)
Such studies have generally focused on use of steroidal and nonsteroidal anti-inflammatory agents that presumably suppress the alveolitis that is believed to precede fibrosis. (cdc.gov)

Dimitroglou Y, Rachiotis G, Hadjichristodoulou C. Exposure to the riot control agent CS and potential health effects: a systematic review of the evidence. (medscape.com)
Revisiting Risk and Benefit in Early Oncology Trials in the Era of Precision Medicine: A Systematic Review and Meta-Analysis of Phase I Trials of Targeted Single-Agent Anticancer Therapies. (cdc.gov)

Anti-inflammatory or immunosuppressive- 2.5-10 mg/kg/day or 75-300 mg/m 2 /day in 3-4 divided doses. (drugguide.com)

Bronchodilators and anti-inflammatory environmental irritants, viral infections, agents were the most common medications prescribed. (cdc.gov)

[ 65 ] Current anti- H pylori regimens include a variety of drug combinations. (medscape.com)
For example, a tuberculosis drug called iproniazid also happened to make people happier and therefore became the first marketed anti-depressant. (harvard.edu)
Drug therapy of immune-mediated inflammatory arthropathies is not always satisfactory, and there is a risk of adverse events. (drugsincontext.com)

Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin, forestomach, and colon when it is administered during initiation and/or postinitiation stages. (aacrjournals.org)

Each participant had undergone one to several previous conventional therapies and/or biologic agents. (thearthritisconnection.com)
A small clinical study in moderate-to-severely active RA and a prior inadequate response or intolerance to biologic agents evaluated once-daily filgotinib 100mg, 200mg, or placebo for 24 weeks. (thearthritisconnection.com)

The Working Group conducts a critical review of the pertinent scientific literature and performs an evaluation of the potential of each agent or intervention to prevent cancer in humans. (who.int)
National and international health agencies use the IARC Monographs to guide and support their actions to prevent exposure to agents that are carcinogenic , probably carcinogenic , and possibly carcinogenic to humans. (who.int)

Diagnostic tools include food allergy testing, measuring white blood cell counts, and tests to explore inflammatory markers and toxic agents, such as heavy metals or organic substances. (andersonnaturalmedicine.net)
The most important initial treatment is removing the inflammatory substances themselves. (andersonnaturalmedicine.net)

Topical agents are the most commonly used type of therapy used by dermatologists. (news-medical.net)
Amoxicillin alone or in combination was the most commonly prescribed antimicrobial agents followed by cefuroxime. (who.int)
Commonly used IT analgesic agents specifically in the perioperative setting include local anesthetics, opioids, and adjuncts such as epinephrine. (medscape.com)

ref>Queiroz RD, Carvalho RT, Queiroz Szeles PR, Janovsky C, Cohen M. [https://www.scielo.br/j/rbort/a/CMqTg3cpszfK3JjtShsgQVG/abstract/?lang=en Return to sport after surgical treatment for pubalgia among professional soccer players]. (physio-pedia.com)

Nurses began to occupy new elements, promoting investigation into new ways a position of therapeutic agents, no longer solely and means of care(3). (bvsalud.org)

And the effects are even stronger when these agents are added on to standard antidepressant treatment, the results show. (brightsurf.com)
The researchers therefore set out to review the available evidence and pool the data to see if anti-inflammatory agents work better than dummy (placebo) treatment either alone or when used as add-on therapy to standard antidepressant treatment. (brightsurf.com)
The pooled data analysis suggested that anti-inflammatory agents were better than placebo and enhanced the effects of standard antidepressant treatment. (brightsurf.com)
And the effects were even greater when one or other of these agents was added to standard antidepressant treatment. (brightsurf.com)
In addition, several groups have used this model to evaluate agents for the treatment of pulmonary fibrosis. (cdc.gov)
Carro Martínez AV, Montolio Chiva L, Robustillo Villarino M. Granulocyte and monocyte/macrophage apheresis for the treatment of immune-mediated inflammatory arthropathies: case reports. (drugsincontext.com)

The marked reduction of inflammatory symptoms by ivy leaf extract shows the potential of this medicinal herb with anti-inflammatory, arthritis, rheumatism, gout. (vietketnoi.net)
Gout is a type of inflammatory arthritis, and it is brought on by an excessive buildup of a crystal known as uric acid. (careforyoo.com)

The risk, however, is halved compared with conventional non-steroidal anti-inflammatory agents (NSAIAs). (medsafe.govt.nz)

However, anti-histamine creams are better for individual bites. (pridemenj.com)

Inflammatory signaling pathways had been thought to increase sleep amount during infection, but the zebrafish data suggests that immune signals may also regulate normal waking activity. (harvard.edu)
Abu Bakar MH, Shariff KA, Tan JS, Lee LK (2020) Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways. (mitophysiology.org)

The objective of the Handbooks programme is the preparation of critical reviews and evaluations of evidence on the cancer-preventive and other relevant properties of a wide range of potential cancer-preventive agents and strategies by international working groups of experts. (who.int)
Cancer prevention builds on the identification and evidence-based evaluation of agents and interventions (including chemopreventive agents, personal interventions, cancer screening, and policy measures) that reduce the risk of developing cancer. (who.int)
Agents and interventions are selected for evaluation based on (i) the feasibility of the intervention and (ii) the availability of some published scientific evidence of cancer-preventive effects. (who.int)
Evidence-based primary cancer prevention builds on the identification and evaluation of environmental causes of cancer (including chemicals, complex mixtures, physical agents, biological agents, occupational exposures, and other exposures of everyday life). (who.int)
Agents are selected for evaluation based on (i) evidence of human exposure and (ii) some published scientific evidence of cancer-causing effects, which together combine into the potentially preventable cancer burden. (who.int)

Intrathecal (IT), often referred to as "spinal," anesthesia refers to the delivery of anesthetic agents to the subarachnoid layer of the spinal column into cerebrospinal fluid (CSF) surrounding the spinal cord. (medscape.com)

Antimicrobial agents (e.g. antibiotic, antifungal, insecticide, antiseptic agents) to prevent or eradicate infections of infestations. (news-medical.net)
OBJECTIVE: This study aimed to assess the bacterial profile of urinary tract infections, their susceptibility to antimicrobial agents, and associated factors in under-five children at Hiwot Fana Specialized University Hospital, eastern Ethiopia. (bvsalud.org)

Dressings are often needed as part of dermatologic therapy to protect areas of the skin, enhance healing, improve absorption of topical agents and protect the clothing of the patient. (news-medical.net)
Occlusive dressings allow less airflow and help to increase the absorption and effectiveness of topical agents applied to the area. (news-medical.net)

Agents increasing serum potassium: Risk of hyperkalemia. (nih.gov)
Vitamin D: an essential adjuvant therapeutic agent in breast cancer - J Int Med Res 2022 Jul - 'Low serum levels of vitamin D have been reported as a risk factor for breast cancer. (qualitycounts.com)

Withania somnifera has been used as an antioxidant, adaptogen, aphrodisiac, liver tonic, anti-inflammatory agent and astringent and more recently as an antibacterial, antihyperplycemic and antitumoral, as well as to treat ulcers and senile dementia ( Rastogi and Mehrotra, 1998 ). (scialert.net)

In essence, the research suggests that lithium is a brain anti-aging nutrient. (tahomaclinicblog.com)

Noni fruit puree compares favorably in analgesic and anti-inflammatory activity to tramadol and hydrocortisone, respectively, in an animal model of arthritis. (greenmedinfo.com)
In comparison to many hydrocortisone formulas, this formula has stronger anti-itch power. (pridemenj.com)

CNS, hemodynamic, pulmonary, and hepatic dysfunction may occur with certain agents, but the relationship to prostaglandin production remains uncertain. (medscape.com)

These agents were 52% more effective in reducing symptom severity, overall, and 79% more effective in eliminating symptoms than placebo, as measured by an average fall in depression scales of 55. (brightsurf.com)

Microbes and their derivatives by producing antigens and other inflammatory factors may trigger infection and inflammatory responses. (shengsci.com)

Beta -adrenergic agonists, 2 inflammatory agents. (cdc.gov)
Tenormin is a beta-adrenergic blocking agent. (canadianbopharmacy.com)

All compounds were evaluated for their in vivo anti-inflammatory and analgesic activities in mice. (hacettepe.edu.tr)
Using a syngeneic colorectal tumour model in mice, we found that, while both agents significantly inhibited tumour growth in vivo, this effect was particularly pronounced for F-DiA. These data identify two compounds that are active against colorectal cancer in vitro and in vivo. (spandidos-publications.com)

Surgery promotes tumor cell migration in a complex fashion involving inflammatory factors, catecholamines, and pro-metastatic enzymes. (biomedcentral.com)

The medicinal ivy leaf extract has been tested for its anti-inflammatory properties. (vietketnoi.net)
Withaferin A and 3-β-hydroxy-2, 3 dihydro withanolide F show promising antibacterial, antitumour, immunomodulating and anti-inflammatory properties. (scialert.net)

IMSEAR at SEARO: Effect of some non-steroidal anti-inflammatory agents on blood sugar level and on insulin-induced hypoglycaemia in albino rats. (who.int)
The compounds carrying a 3-phenyl-2-propenylidene (1a), (biphenyl-4-yl) methylidene (1f) and (1-methylpyrrol-2-yl)methylidene (1n) at the 6th position of the fused ring have been evaluated as potential analgesic/anti-inflammatory agents without a gastrointestinal side effect. (hacettepe.edu.tr)
We also studied the modulating effect of this agent on apoptosis in the tumors. (aacrjournals.org)
However, these agents cannot be universally recommended for prevention purposes due to their potential side-effect profiles. (spandidos-publications.com)
For all assays, F-DiA had a more rapid and significant effect than DiA, identifying this agent as particularly active against colorectal cancer. (spandidos-publications.com)
Ivy leaves are not only famous for cough remedies, liver detoxification but it also has a great effect in fighting inflammatory problems of the body. (vietketnoi.net)

Anatomy3

Organisms24

Diseases1

Chemicals and Drugs38

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes4

Technology, Industry, Agriculture1

Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension. (1/7426)

Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. (2/7426)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (3/7426)

Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. (4/7426)

Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. (5/7426)

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (6/7426)

The effect of streptomycin, oxytetracycline, tilmicosin and phenylbutazone on spermatogenesis in bulls. (7/7426)

Pseudogout attack associated with chronic thyroiditis and Sjogren's syndrome. (8/7426)

Anti-Inflammatory Agents, Non-Steroidal

Inflammation

Okadaic Acid

Lipopolysaccharides

Transcription Factor RelA

Tumor Necrosis Factor-alpha

Inflammation Mediators

I-kappa B Kinase

I-kappa B Proteins

NF-kappa B

Interleukin-1

Steroids

Tetradecanoylphorbol Acetate

Macrophages

Cells, Cultured

Spirostans

Gene Expression Regulation

Saponins

Glycosides

Diosgenin

Tomatine

Liliaceae

Solanaceous Alkaloids

Chlormadinone Acetate

Molecular Structure

Pregnanes

Cynanchum

Androstanes

Estrogen Antagonists

Rhizome

Magnetic Resonance Spectroscopy

Dracaena

Smilax

Buxaceae

Solanum

Dioscorea

Allium

Aromatase Inhibitors

Withanolides

Plant Extracts

Testolactone

Holarrhena

Estradiol

Anemarrhena

Hydroxysteroids

Stereoisomerism

Molecular Conformation

Asparagus Plant

Spectrometry, Mass, Fast Atom Bombardment

Solanum nigrum

Alveolectomy

Androstenes

Withania

Agave

Ophiopogon

Chloroquinolinols

Trillium

Tropaeolaceae

Gestrinone

Phytosterols

Hemolytic Agents

Convallaria

Androstanols

Marsdenia

Solanaceae

Agavaceae

Fritillaria

Estrogens

Pregnenes

Veratrum

Hosta

Cyproterone Acetate

Solanine

Subgingival Curettage

Dose-loading with hydroxychloroquine improves the rate of response in early, active rheumatoid arthritis: a randomized, double-blind six-week trial with eighteen-week extension. (1/7426)

Non-steroidal anti-inflammatory drug-induced apoptosis in gastric cancer cells is blocked by protein kinase C activation through inhibition of c-myc. (2/7426)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (3/7426)

Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. (4/7426)

Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. (5/7426)

Reduction of sodium deoxycholic acid-induced scratching behaviour by bradykinin B2 receptor antagonists. (6/7426)