A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The characteristic three-dimensional shape of a molecule.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
Antibodies produced by a single clone of cells.
Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.
A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).
A nucleoside consisting of the base guanine and the sugar deoxyribose.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Cytosine nucleotides which contain deoxyribose as the sugar moiety.
A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Adenine nucleotides which contain deoxyribose as the sugar moiety.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Use of plants or herbs to treat diseases or to alleviate pain.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
The structure of one molecule that imitates or simulates the structure of a different molecule.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
The rate dynamics in chemical or physical systems.
Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
A cell line derived from cultured tumor cells.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Substances that reduce or suppress INFLAMMATION.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Elements of limited time intervals, contributing to particular results or situations.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
An encapsulated lymphatic organ through which venous blood filters.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
Proteins prepared by recombinant DNA technology.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment. (1/7049)

AIM: To examine the effect of corticosteroid treatment on the expression of inducible nitric oxide synthase (iNOS) in the colon of patients with inflammatory bowel disease. METHODS: Four groups of patients were studied: (1) ulcerative colitis treated with high dose corticosteroids (six patients, 10 blocks); (2) ulcerative colitis patients who had never received corticosteroids (10 patients, 16 blocks); (3) Crohn's disease treated with high dose corticosteroids (12 patients, 24 blocks); (4) Non-inflammatory, non-neoplastic controls (four patients, six blocks). Full thickness paraffin sections of colons removed at surgery were immunostained with an antibody raised against the C terminal end of iNOS. Sections were assessed semiquantitatively for the presence and degree of inflammation and immunoreactivity for nitric oxide synthase. RESULTS: Cases of ulcerative colitis and Crohn's disease with active inflammation showed strong staining for nitric oxide synthase. The staining was diffuse in ulcerative colitis and patchy in Crohn's disease, in accordance with the distribution of active inflammation. Staining was seen in epithelial cells and was most intense near areas of inflammation such as crypt abscesses. Non-inflamed epithelium showed no immunoreactivity. Treatment with corticosteroids made no difference to the amount of nitric oxide synthase. CONCLUSIONS: Expression of nitric oxide synthase is increased in both ulcerative colitis and Crohn's disease and appears to be unaffected by treatment with corticosteroids. Disease severity necessitated surgery in all the cases included in this study, regardless of whether or not the patients had received long term corticosteroid treatment. It seems therefore that a high level of iNOS expression and, presumably, production of nitric oxide characterise cases which are refractory to clinical treatment; this suggests that specific inhibition of the enzyme may be a useful therapeutic adjunct.  (+info)

Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids. (2/7049)

Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.  (+info)

Pharmacological studies on root bark of mulberry tree (Morus alba L.) (3/7049)

Pharmacological studies were done on the root bark of mulberry tree and pharmacological effects were compared with the clinical effects of "Sohakuhi" in Chinese medicine. n-Butanol- and water-soluble fractions of mulberry root had similar effects except for those on the cadiovascular system. Both fractions showed cathartic, analgesic, diuretic, antitussive, antiedema, sedative, anticonvulsant, and hypotensive actions in mice, rats, guinea pigs and dogs. There appears to be a correlation between the experimental pharmacological results and the clinical applications of mulberry root found in the literature on Chinese medicine.  (+info)

Analysis of Chinese herbal creams prescribed for dermatological conditions. (4/7049)

OBJECTIVE: To determine whether Chinese herbal creams used for the treatment of dermatological conditions contain steroids. DESIGN: 11 herbal creams obtained from patients attending general and paediatric dermatology outpatient clinics were analysed with high resolution gas chromatography and mass spectrometry. SETTING: Departments of dermatology and clinical biochemistry. MAIN OUTCOME MEASURE: Presence of steroid. RESULTS: Eight creams contained dexamethasone at a mean concentration of 456 micrograms/g (range 64 to 1500 micrograms/g). All were applied to areas of sensitive skin such as face and flexures. CONCLUSION: Greater regulation needs to be imposed on Chinese herbalists to prevent illegal and inappropriate prescribing of potent steroids.  (+info)

Characteristics of spontaneous erythema appeared in hairless rats. (5/7049)

The hairless rat (WBN/Kob-Ht), a dominant mutant rat derived from the Wistar strain, rarely develops spontaneous erythema of a progressive nature on its skin. Erythema was first observed at 8 weeks of age and the incidence at 20 weeks of age was about 4% in both males and females. Histopathologically, erythema was characterised by dermatitis induced by an immunological reaction. Areas of erythema in the skin were decreased by treatment with dexamethasone (1 mg/kg) or ciclosporin (25 or 50 mg/kg). These results suggested that erythema on the hairless rat could be used as an animal model of spontaneous dermatitis.  (+info)

Topical psoriasis therapy. (6/7049)

Psoriasis is a common dermatosis, affecting from 1 to 3 percent of the population. Until recently, the mainstays of topical therapy have been corticosteroids, tars, anthralins and keratolytics. Recently, however, vitamin D analogs, a new anthralin preparation and topical retinoids have expanded physicians' therapeutic armamentarium. These new topical therapies offer increased hope and convenience to the large patient population with psoriasis.  (+info)

Altered leucocyte trafficking and suppressed tumour necrosis factor alpha release from peripheral blood monocytes after intra-articular glucocorticoid treatment. (7/7049)

OBJECTIVES: A generalised transient improvement may follow intra-articular administration of glucocorticoids to patients with inflammatory arthropathy. This may represent a systemic anti-inflammatory effect of glucocorticoid released from the joint, mediated through processes such as altered leucocyte trafficking or suppressed release of pro-inflammatory cytokines. Patients, who had received intra-articular injections of glucocorticoids were therefore studied for evidence of these two systemic effects. METHODS: Patients with rheumatoid arthritis were studied. Peripheral blood leucocyte counts, tumour necrosis factor alpha (TNF alpha) release by peripheral blood monocytes, blood cortisol concentrations, and blood methylprednisolone concentration were measured for 96 hours after intra-articular injection of methylprednisolone acetate. RESULTS: Measurable concentrations of methylprednisolone were present in blood for up to 96 hours after injection. Significant suppression of the hypothalamic-pituitary-adrenal axis persisted throughout this time. Altered monocyte and lymphocyte trafficking, as evidenced by peripheral blood monocytopenia and lymphopenia, was apparent by four hours after injection and resolved in concordance with the elimination of methylprednisolone. Granulocytosis was observed at 24 and 48 hours. Release of TNF alpha by endotoxin stimulated peripheral blood monocytes was suppressed at four hours and thereafter. Suppression was maximal at eight hours and was largely reversed by the glucocorticoid antagonist, mifepristone. CONCLUSIONS: After intra-articular injection of methylprednisolone, blood concentrations of glucocorticoid are sufficient to suppress monocyte TNF alpha release for at least four days and to transiently alter leucocyte trafficking. These effects help to explain the transient systemic response to intra-articular glucocorticoids. Suppression of TNF alpha is principally a direct glucocorticoid effect, rather than a consequence of other methylprednisolone induced changes to blood composition.  (+info)

A comparative study of the effects of ketotifen, disodium cromoglycate, and beclomethasone dipropionate on bronchial mucosa and asthma symptoms in patients with atopic asthma. (8/7049)

Asthma is a chronic inflammatory disorder of the airways that is characterized by infiltration of many inflammatory cells into the bronchial mucosa. We compared the effects of ketotifen, disodium cromoglycate (DSCG), and beclomethasone dipropionate (BDP) on inflammatory cells in the bronchial mucosa and on the asthma symptoms of patients with atopic asthma. In this 12-week parallel study, 32 patients were randomly allocated to either the ketotifen group (2 mg day-1, n = 13), DSCG group (8 mg day-1, n = 9) or BDP (400 micrograms day-1, n = 10). Each subject recorded daily asthma symptoms and peak expiratory flow (PEF). Before and after treatment, pulmonary function and bronchial responsiveness to methacholine were evaluated, and fibreoptic bronchoscopy and biopsy were performed before and after treatment. Biopsy specimens were obtained by bronchoscopy. We performed immunohistochemistry using specific monoclonal antibodies for activated eosinophils (EG2), mast cells (AA1), and T cells (CD3, CD4, and CD8). Our clinical findings showed significant improvement in symptom score and bronchial responsiveness (P < 0.01) each) in all groups. Both the DSCG and the BDP groups had significantly better symptom scores than the ketotifen group (P < 0.05, both groups). PEF significantly increased in the DSCG group in comparison to the ketotifen (P < 0.01) and BDP (P < 0.05) groups, FEV1% increased significantly in the DSCG (P < 0.01) and BDP (P < 0.05) groups in comparison to the ketotifen group. Compared with their baseline values, treatment significantly decreased EG2+ activated eosinophils, and CD3+ and CD4+ T cells, in each group (P < 0.01). Both the DSCG (P < 0.05) and the BDP groups (P < 0.01) exhibited significant decreases in AA1+ mast cell count, but this was not observed in the ketotifen group. Comparing before- and after-treatment values, only the DSCG group exhibited a significant decrease in the number of CD8+ T cells (P < 0.01). Ketotifen, DSCG, and BDP all showed anti-inflammatory activity as determined by examination of the bronchial mucosa of asthmatic patients; and both the DSCG and BDP groups had better clinical responses than the ketotifen group.  (+info)

(a) In vitro anti-inflammatory activities (COXI, II and LOXV inhibition activities) of the green mussel formulation compared with standard anti-inflammatory dru
The most frequent fungal threat to humans, Candida albicans, is a common cause oral and genital infection. The fungal infections are often worsened by overwhelming inflammatory responses in the body and cause high mortality among risk groups. Umeå University doctoral student Ava Hosseinzadeh has discovered two novel anti-inflammatory agents, an antioxidant and an anti-inflammatory molecule, which could be used to control the hyper-inflammatory responses to the fungal infection ...
Anti-Inflammatory Foods. Have you ever had an injury where you have to take anti-inflammatory medications? Or maybe you are clumsy and continuously hurt yourself by stubbing a toe on the bed post or running into a door at night. Either way, instead of just taking anti-inflammatory medication, there are foods you can eat that act as anti-inflammatory agents. Well, maybe not directly, but definitely by contrasting the enemy - foods that induce inflammation. There are foods that can actually slow down the progression of your healing when related to such. Two of them are high-fat and high-carbohydrate foods.. If you are recovering from an injury with inflammation, just stay away from both of those. They will slow your healing and deliberately un-hurry your anti-inflammatory meds. Instead, take the opposite approach and eat foods high in protein and nutrient-rich produce, along with some healthy fats. A meal including a Pineapple Salmon Dish, with a side of Spinach would be a good start. You can also ...
Dr. Weeks Comments: How do statins work? They are anti-inflammatory agents. Simple as that. The cholesterol lowering effect derives from anti-inflammation processes. Like aspirin. But unlike aspirin, they destroy the bodys essential energy source Co enyzme Q 10 (CoQ10). So, yes, statins are being marketed broadly - see below - (also against cancer) but anti-inflammatory agents which dont destroy CoQ 10 are better for you; and SOUL is the safest and most effective anti-inflammatory agent we know of at this time! Statins prevent cataracts, study suggests (August 31, 2013) - Statins lower the rate of cataract by 20 percent, according to new research. The risk of cataract was reduced by 50 percent when treatment was initiated in younger individuals (in their 40s) and the duration of therapy was longer (e.g. up to 14 years). … , full story. High dose statins prevents dementia, study suggests (August 31, 2013) - High doses of statins prevent dementia in older people, according to new research. ...
Synonyms for Anti-inflammatory agents in Free Thesaurus. Antonyms for Anti-inflammatory agents. 1 synonym for anti-inflammatory: anti-inflammatory drug. What are synonyms for Anti-inflammatory agents?
Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid
In an ovalbumin (OVA)-driven murine model of allergic pulmonary inflammation, we have shown previously that moderate-intensity aerobic exercise training attenuates inflammatory responses, disease progression, and NF-κB activation within the sensitized lung. Glucocorticoids (GCs), potent anti-inflammatory agents, have been shown to alter transcriptional events that are important in asthmatic pathogenesis, such as NF-κB activation. Notably, exercise training can alter the production and signaling capacity of endogenous GCs. Because GCs exert their anti-inflammatory effects through binding to intracellular glucocorticoid receptors (GRs), we examined the role of the GR in facilitating the anti-inflammatory effects of exercise. Results show that, in exercised OVA-sensitized mice, treatment with the GR antagonist RU486 blocked the exercise-induced reductions in cellular infiltration of the airways (p < .05), KC and soluble VCAM-1 protein levels in the bronchoalveloar lavage fluid (p < .05), and ...
EP is a simple aliphatic ester derived from pyruvic acid that has been shown to be an effective anti-inflammatory agent in a variety of in vivo and in vitro model systems (Fink,2003). It is well known that pyruvate is an ROS scavenger (Adickes and Andresen, 1943; Bunton, 1949; Melzer and Schmidt, 1988; Dobsak et al., 1999), and data are available suggesting that EP is as well (Varma et al., 1998; Tawadrous et al., 2002). NAC, a derivative of the amino acid l-cysteine, is both an ROS scavenger itself (Aruoma et al., 1989) and a precursor for the synthesis of the important endogenous antioxidant, GSH (Fernandez et al., 1999). Since redox-sensitive signaling pathways are thought to regulate the expression of various pro- and anti-inflammatory mediators involved in the innate immune response (Janssen-Heininger et al., 2000; Garg and Aggarwal, 2002; Haddad, 2002a), we sought to compare the pharmacological effects of similar concentrations of EP and the widely employed reagent, NAC.. Our studies ...
Inflammation is a beneficial mechanism that is usually triggered by injury or infection and is designed to return the body to homeostasis. However, uncontrolled or sustained inflammation can be deleterious and has been shown to be involved in the etiology of several diseases, including inflammatory bowel disorder and asthma. Therefore, effective anti-inflammatory signaling is important in the maintenance of homeostasis in the body. However, the inter-play between pro- and anti-inflammatory signaling is not fully understood. In the present study, we develop a mathematical model to describe integrated pro- and anti-inflammatory signaling in macrophages. The model incorporates the feedback effects of de novo synthesized pro-inflammatory (tumor necrosis factor alpha; TNF-a) and anti-inflammatory (interleukin-10; IL-10) cytokines on the activation of the transcription factor nuclear factor kappaB (NF-kB) under continuous lipopolysaccharide (LPS) stimulation (mimicking bacterial infection). In the ...
Walter and Eliza Hall Institute scientists have developed a new drug-like molecule that can halt inflammation and has shown promise in preventing the progression of multiple sclerosis (MS).
Anti-Inflammatory Treatment of Acute and Chronic Soft-Tissue Sports Injuries from Medscape Pharmacotherapy Louis C. Almekinders, MD, Associate
A series of ninety-seven diarylpentanoid derivatives were synthesized and evaluated for their anti-inflammatory activity through NO suppression assay using interferone gamma (IFN-γ)/lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Twelve compounds (9, 25, 28, 43, 63, 64, 81, 83, 84, 86, 88 and 97) exhibited greater or similar NO inhibitory activity in comparison with curcumin (14.7 ± 0.2 µM), notably compounds 88 and 97, which demonstrated the most significant NO suppression activity with IC50 values of 4.9 ± 0.3 µM and 9.6 ± 0.5 µM, respectively. A structure-activity relationship (SAR) study revealed that the presence of a hydroxyl group in both aromatic rings is critical for bioactivity of these molecules. With the exception of the polyphenolic derivatives, low electron density in ring-A and high electron density in ring-B are important for enhancing NO inhibition. Meanwhile, pharmacophore mapping showed that hydroxyl substituents at both meta- and para-positions of ring-B ...
The results of this study confirm that systemic administration of L salivarius 118 had an anti-inflammatory effect on colitis in IL-10 KO mice, demonstrating that the oral route is not mandatory for its effect. It is noteworthy that the anti-inflammatory effect was of comparable, but not superior, magnitude to that previously reported by us using the oral route of administration.9 Dosing and frequency of administration were arbitrary, with a compromise between exposure to the microbes while minimising stress to the animals. Whether alternative regimens would have a greater or lesser impact requires study. The results are not specific to this model, nor to intestinal inflammation, because the anti-inflammatory effect was also seen in a murine model of arthritis. This further supports an earlier observation that probiotic effects are not solely local, but may include systemic anti-inflammatory activity.9 The systemic nature of the probiotic activity is reflected in a decrease in proinflammatory ...
CLEVELAND -- A novel anti-inflammatory agent significantly decreased the risk of preterm birth in an animal model, investigators found.
Figures were anlyzed working with the two-tailed Students t-test in Microsoft Excel. Statistical importance was taken as p,.05. Cells were being lysed in
The use of steroids to treat atopic dermatitis (AD) often causes side effects; thus, the authors present a blend of plant-derived materials designed as an alternative treatment or an adjuvant therapeutic agent. Through in vitro and in vivo evaluations, the blend is shown to provide effective anti-inflammatory and AD-mitigating effects.
Systemic corticosteroidsThese are potent anti-inflammatory agents because of their effects on many cell types (eg, mast cells, eosinophils, neutrophils, macrophages, basophils, lymphocytes) and on the... more
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Researchers have found a way to manipulate programmed cell death, a normal process that goes awry in chronic inflammatory disorders, cancer and other diseases. A key step in preventing cell suicide is induction of a protein that collects and hoards iron, which cells need to make the harmful substances that induce death. Drugs that alter iron metabolism could provide effective anti-inflammatory therapy without the side effects that come with current treatments.
Inhaled CorticosteroidsSteroids are the most potent anti-inflammatory agents. Inhaled forms are topically active, poorly absorbed, and least likely to cause adverse effects. They are used for long-ter... more
Dexamethasone Injectable is a prescription anti-inflammatory used to treat bovine ketosis and other diseases known to be responsive to anti-inflammatory corticosteroids.
Ciprodex otic is used to treat bacterial ear infections. It contains a ciprofloxacin 0.3% and dexamethasone 0.1%. Ciprofloxacin is a quinolone-type antibiotic. Dexamethasone is an anti-inflammatory corticosteroid. - Stock Image C028/0256
I have been researching supplements like crazy! Trying to figure out what would be the best for my very active 19 year old jumper. He looks and acts like a 12 year old. I was using a combo product but have read an excerpt from John Lyons Perfect Horse DEC2007/Jan2008 issue that MSM is an effective anti-inflammatory but that a study in horses with hock arthritis showed it takes a dose of at least 20,000 mg a day to be effective. So it is best to buy it by itself so you can adjust the dosage! I will use Vita-Flex MSM ...
DPP-4 inhibitors have different effects on endothelial low grade inflammation and on the M1-M2 macrophage polarization under hyperglycemic conditions
Magnesium is an important mineral which is responsible for over 300 different metabolic processes within the body. It is a very effective anti-inflammatory mineral.
Citation : Pal, R.K. et al. (2012) Synthesis of 5, 6-dichloroindan-1-acids and their tetrazolyl derivatives as analgesic and anti-inflammatory agents. Medicinal Chemistry, 8 (5), pp. 874-882 ...
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The seeds of Vigna genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of V. vexillata demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of V. vexillata. One new sterol (1) and two new isoflavones (2,3) were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23), abscisic acid (25), and quercetin (40) displayed the most significant inhibition of superoxide anion generation and elastase release.
3bym: Structure-based design of novel 2-amino-6-phenyl-pyrimido[5,4:5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.
It is obvious from this discussion that GRPU is a complex disease with no firm understanding regarding genetics. Additionally, one study (Esson et al) has theorized that uveitis is not present in GRPU, based on histopathologic evaluation of eyes enucleated due to glaucoma. 4 However, other authors believe that uveitis is indeed present, and that the eyes from the Esson study showed little evidence of uveitis because the eyes had been treated with anti-inflammatory medication prior to their removal. It is Dr. McCallas opinion that because dogs with GRPU clinically respond favorably to anti-inflammatory medication, this is indirect evidence that inflammation is a component of the disease. It is obvious that in order to better understand GRPU, longterm studies of large numbers of dogs affected with GRPU are necessary. 2 There is no best treatment regimen; all treatment regimens used by veterinary ophthalmologists are based on their personal clinical experience with the disease and not on ...
The diversity of proteins in the blood that promote inflammation in people with type 1 diabetes and related kidney disease calls for personalized treatment | Immunology
Hello and welcome to our new Anti-Inflammatory Crystal Healing Technique.. This course consists of 13 sections, with detailed text and photos and supported by 50 videos.. A sampling of the videos can be found in our Blog section here.. Whether you are seeking to help yourself, or seeking to help others, you will find significant, state of the art information here. This is my original work. You will not be able to find anything like it anywhere else.. Although I have researched and developed this technique specifically to address chronic inflammation, a serious and pervasive dynamic of many of our modern-day health issues, you can also use this technique in cases of acute inflammation.. This is a comprehensive course, equivalent to a 3-Day Weekend Workshop. I have been teaching for 35 years now, and I have been careful to present the material to honor the way in which people learn most successfully - focusing on one learning objective at a time. To avoid overwhelming you with too many details at ...
Charles N. Serhan, Rong Yang, Kimberly Martinod, Kie Kasuga, Padmini S. Pillai, Timothy F. Porter, Sungwhan F. Oh, Matthew Spite ...
Adrien Gagnon GO Joints Anti-Inflammatory - Adrien Gagnon GO Joints Anti-Inflammatory is a very powerful anti-inflammatory. It relieves joint pa
Harnessing the anti-inflammatory function of macrophages using the Gas6 switch holds great potential where inflammation is a key underlying feature
Anti-Inflammatory property of a substance or treatment that reduces inflammation. Anti-inflammatory drugs make up one half of analgesics, remedying pain by reducing inflammation as opposed to opioids which affect the brain
This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results.
Greenmedinfo.com - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
The best anti-inflammatory supplements will reduce your inflammation and ease your pain naturally. Find anti-inflammatory herbs and better alternatives to aspirin and advil here.
Inflammation plays a role in the development of MS. Could an anti-inflammatory diet help prevent it or reduce the nerve damage it causes? While the jurys still out on those questions, anti-inflammatory foods are healthy additions to an MS diet.
Find great deals on sendisteroids.com for anti-inflammatory corticoteroids with our factory. Were known as one of professional anti-inflammatory corticoteroids manufacturers and suppliers in China. Please rest Assured to buy.
The kidney is responsible for filtering your blood 24/7. In order to keep it healthy, not only do you need a scientifically correct diet but one which does not pose excess stress on the nephrons. These ingredients naturally purify the blood and have an anti-inflammatory effect on the kidney. Extremely helpful for indiv
Fasting Improves Your Brain Function New research has indicated that fasting can significantly reduce the effects of aging on the brain. It has been known that bouts of intermittent fasting have a powerful anti-inflammatory effect on the entire...
The hallmarks indicate a combination of interferon supplementation and anti-inflammatory therapies could be used to treat critical COVID-19 patients.
Beat chronic inflammation by making a slight shift in your lifestyle, supplementing with anti-inflammatory herbs, and removing inflammatory foods from your diet.
Anti-inflammatory definition, acting to reduce certain signs of inflammation, as swelling, tenderness, fever, and pain. See more.
When preparing meals, individuals can choose anti-inflammatory foods such as pasture-raised chicken, grass fed beef and nitrate-free turkey bacon as a main dish, according to Dr. Frederick T. Sutter...
Study Flashcards On Anti-Inflammatory at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Anti-inflammatory agents[edit]. *Prednisolone. Local anesthetics[edit]. *Tetracaine. Miotics and antiglaucoma medicines[edit]. ... Non-opioids and non-steroidal anti-inflammatory medicines (NSAIMs)[edit]. A skeletal model of the chemical structure of aspirin ... Not recommended for antiinflammatory use due to lack of proven benefit to that effect ... Lipid-lowering agents[edit]. *Simvastatin[note 72]. Dermatological medicines (topical)[edit]. Antifungal medicines[edit]. * ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] ... Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease ... It is used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease.[2] It is generally used for ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... Rifaximin possesses anti-inflammatory and antibacterial properties and additionally, it is a nonabsorbable antibiotic that acts ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties.[32][33] Prednisone is ... "Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ... Prednisone is used for many different autoimmune diseases and inflammatory conditions, including asthma, gout, COPD, CIDP, ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... "Antimicrob Agents Chemother. 34 (6): 1227-31. doi:10.1128/AAC.34.6.1227. PMC 171789 . PMID 2393284.. ... "Antimicrob Agents Chemother. 23 (1): 138-41. doi:10.1128/AAC.23.1.138. PMC 184631 . PMID 6219616.. ... "Antimicrob Agents Chemother. 34 (4): 543-9. doi:10.1128/AAC.34.4.543. PMC 171641 . PMID 2344161.. ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... along with an anticaking agent such as cellulose) sprinkled on or mixed into the product. While not currently approved for use ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... The activated glucocorticoid receptor-glucocorticoid complex up-regulates the expression of anti-inflammatory proteins in the ... I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer ... Rhen T, Cidlowski JA (Oct 2005). "Antiinflammatory action of glucocorticoids--new mechanisms for old drugs". The New England ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... is an aminosalicylate anti-inflammatory drug[2] used to treat inflammatory bowel disease, including ulcerative colitis,[3][4][5 ...
1 V10A Anti-inflammatory agents *1.1 V10AA Yttrium (90Y) compounds. *1.2 V10AX Other anti-inflammatory therapeutic ... V10A Anti-inflammatory agents[szerkesztés]. V10AA Yttrium (90Y) compounds[szerkesztés]. V10AA01 Yttrium (90Y) citrate colloid. ... V10AX Other anti-inflammatory therapeutic radiopharmaceuticals[szerkesztés]. V10AX01 Phosphorus (32P) chromicphosphate colloid ... V10B Pain palliation (bone seeking agents)[szerkesztés]. V10BX Various pain palliation radiopharmaceuticals[szerkesztés]. ...
... is used as an anti-inflammatory agent for both acute and long-term inflammation,[37] as well as for treatment of ... 1982). "Aspirin and similar analgesic and anti-inflammatory agents". Martindale: the extra pharmacopoeia (28th ed.). ... Aspirin-modified PTGS2 produces lipoxins, most of which are anti-inflammatory.[139][verification needed] Newer NSAID drugs, COX ... "Nonsteroidal Anti-inflammatory Drugs: Aspirin". Merck Veterinary Manual. Archived from the original on 2016-12-18. Retrieved ...
pain: anti-inflammatory agents or analgesics should be taken. *swelling: intermittent ice will aid in eradicating this. ... Extrusion of sodium hypochlorite irrigating solution during a root canal procedure can cause a severe inflammatory reaction and ... paraesthesia: usually transient as a result of inflammatory swelling, and sensation will return to normal in 4 weeks ...
... has been investigated in animal models as a potential anti-inflammatory agent.[10] [11] Vinpocetine inhibits the up ... "Vinpocetine as a potent antiinflammatory agent". Proceedings of the National Academy of Sciences of the United States of ... "Vinpocetine inhibits glutamate release induced by the convulsive agent 4-aminopyridine more potently than several antiepileptic ...
... a new class of anti-inflammatory agents?". Current Medicinal Chemistry. 9 (6): 663-74. doi:10.2174/0929867023370707. PMID ... It has anti-inflammatory activity and also attenuates pain sensation.[7][8][9] in mammals. NAE 16:0 has also been identified in ... It has anti-proliferative effects on prostate cancer cell lines and promotes synaptogenesis.[14][15] ... "Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor- ...
Inhibits diverse inflammatory responses in animal models; structural model for developing anti-inflammatory agents[10][57][58] ... are less inflammatory, or inactive, or even anti-inflammatory and pro-resolving. ... Inhibition of COX-1 and/or the inducible COX-2 isoforms, is the hallmark of NSAIDs (non-steroidal anti-inflammatory drugs), ... PGA1, PGA2, PGJ2, Δ12-PGJ2, and 15-deox-Δ12,14-PGJ2 exhibit a wide range of anti-inflammatory and inflammation-resolving ...
9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3. Austin RJ, Maschera B, Walker A, ... It is believed that the action of corticosteroid anti-inflammatory agents is bound to inhibitive proteins of phospholipase A2, ... Reversing the activation of inflammatory proteins Activating the secretion of anti-inflammatory proteins Stabilizing cell ... Mometasone furoate can be used with formoterol for the treatment of asthma, due to its anti-inflammatory properties. People ...
Trichostatin A (TSA) and others are being investigated as anti-inflammatory agents. After the successful initial round of in ... Adcock IM (April 2007). "HDAC inhibitors as anti-inflammatory agents". British Journal of Pharmacology. 150 (7): 829-31. doi: ... HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. The prime example of this ... HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. More recently they are ...
"HDAC inhibitors as anti-inflammatory agents". Br. J. Pharmacol. 150 (7): 829-31. doi:10.1038/sj.bjp.0707166. PMC 2013887. PMID ... Thus, TSA has some potential as an anti-cancer drug. One suggested mechanism is that TSA promotes the expression of apoptosis- ... HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this ... "Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view". Curr Med ...
Stewart, William K.; Fleming, L. W. (1 October 1987). "Perthshire Pioneer of Anti-Inflammatory Agents". Scottish Medical ... He carried out research into the effect of salicin, an extract from willow bark and a known anti-rheumatic treatment. This work ... pharmacologist from Perthshire who pioneered the clinical use of thermometers and the use of salicin as an anti-inflammatory ...
EF Reynolds (編). Aspirin and similar analgesic and anti-inflammatory agents. Martindale: The Extra Pharmacopoeia 28th: 234-82. ... Nonsteroidal anti-inflammatory drug-induced reactions and desensitization. J Asthma. 2004, 41 (4): 375-84. PMID 15281324. doi: ... FDA Strengthens Warning of Heart Attack and Stroke Risk for Non-Steroidal Anti-Inflammatory Drugs. FDA. 2015-07-09 [2015-07-09] ... Pharmacokinetic Solubility And Dissolution Profile of Non-Steroidal Anti-Inflammatory Drugs 2 (3). 2011.. ...
... anti-inflammatory agents like corticosteroids and nonsteroidal anti-inflammatory drugs, antiandrogens, and antihistamines, ... The typical treatment is antifungal cream and anti-inflammatory agents.[3] Specifically ketoconazole or ciclopirox are ... "Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp". Cochrane Database of Systematic Reviews (5 ... Anti-inflammatory treatments[edit]. Topical corticosteroids have been shown to be effective in short-term treatment of ...
The typical treatment is antifungal cream and anti-inflammatory agents.[2] Specifically ketoconazole or ciclopirox are ... "Topical anti-inflammatory agents for seborrhoeic dermatitis of the face or scalp". Cochrane Database of Systematic Reviews. doi ... Anti-inflammatory treatments[edit]. Topical steroids have been shown to be effective in short-term treatment of serborrhoeic ... However, research studies suggest that some antihistamines have anti-inflammatory properties.[36] ...
... acts as an anti-inflammatory agent. Salicin is also commonly found in the bark of Populus species, and the leaves of ... It is also found in castoreum, which was used as an analgesic, anti-inflammatory, and antipyretic. The activity of castoreum ...
"Plant phenylpropanoids as emerging anti-inflammatory agents". Mini Reviews in Medicinal Chemistry. 11 (10): 823-35. doi:10.2174 ...
... is an antiinflammatory agent. More specifically, it is a nonsteroidal anti-inflammatory drug (NSAID) that acts via ... a new nonsteroidal anti-inflammatory agent". Journal of Pharmaceutical Sciences. 64 (9): 1469-75. doi:10.1002/jps.2600640909. ...
แกงหมูกระท้อน แกงคั่วกระท้อนกุ้ง Rasadah, M.A.; Khozirah, S.; Aznie, A.A.; Nik, M.M. (2004). "Anti-inflammatory agents from ... Several parts of the plant may have anti-inflammatory effects, and some chemical extracts from santol stems have shown anti- ... The partly ripe sour fruits are also used as a souring agent in sour broth dishes like sinigang. In Thai cuisine this fruit is ... "Plant anticancer agents, L. Cytotoxic triterpenes from Sandoricum koetjape stems".
Among them are serotonin, a neurotransmitter; indometacin, a non-steroidal anti-inflammatory agent; L-761,066, a COX-2 ...
Olkkola KT, Brunetto AV, Mattila MJ (1994). "Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents". Clinical ... Oxicam is a class of nonsteroidal anti-inflammatory drugs (NSAIDs) that bind closely to plasma proteins. Most oxicams are ...
... is used as an anti-inflammatory agent for both acute and long-term inflammation, as well as for treatment of ... 1982). "Aspirin and similar analgesic and anti-inflammatory agents". Martindale: the extra pharmacopoeia (28th ed.). ... Verdoodt F, Friis S, Dehlendorff C, Albieri V, Kjaer SK (February 2016). "Non-steroidal anti-inflammatory drug use and risk of ... "Nonsteroidal Anti-inflammatory Drugs: Aspirin". Merck Veterinary Manual. Archived from the original on 18 December 2016. ...
The herbage contains antibacterial and anti-inflammatory agents.[citation needed] The leaves of this plant are natural insect ... It is used as a massage oil and an agent of aromatherapy. It may also be diluted, placed in the palms of the hands, and inhaled ...
Competence in S. pneumoniae is induced by DNA-damaging agents such as mitomycin C, fluoroquinolone antibiotics (norfloxacin, ... Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall components are all major ... After S. pneumoniae colonizes the air sacs of the lungs, the body responds by stimulating the inflammatory response, causing ...
Three different PET contrast agents have been developed to image bacterial infections in vivo: [18F]maltose,[19] [18F] ... imaging of atherosclerosis to detect patients at risk of stroke is also feasible and can help test the efficacy of novel anti- ... to identify the infection-associated inflammatory response. ... These agents permit the visualization of neuroreceptor pools in ... PET/CT-System with 16-slice CT; the ceiling mounted device is an injection pump for CT contrast agent ...
... virus is classified as a biosafety level 4 agent, as well as a Category A bioterrorism agent by the Centers for Disease ... Viral replication triggers high levels of inflammatory chemical signals and leads to a septic state.[38] ... people to be careful of advertisements making unverified or fraudulent claims of benefits supposedly gained from various anti- ... Zubray G (2013). Agents of Bioterrorism: Pathogens and Their Weaponization. New York, NY, USA: Columbia University Press. pp. ...
Proposed mechanisms for tea tree oil's anti-acne effects include antibacterial action against C. acnes and anti-inflammatory ... Hormonal agents[edit]. In women, the use of combined birth control pills can improve acne.[100] These medications contain an ... This inflammatory cascade typically leads to the formation of inflammatory acne lesions, including papules, infected pustules, ... and an association between the use of anti-inflammatory medications in the third trimester and adverse effects to the ...
ofatumumab (HuMax-CD20) a fully human B cell-depleting agent.[53]. *Third-generation anti-CD20s such as obinutuzumab have a ... chronic inflammatory demyelinating polyneuropathy and autoimmune anemias.[16] The most dangerous, although among the most rare ... Other anti-CD20 monoclonals[edit]. The efficacy and success of Rituximab has led to some other anti-CD20 monoclonal antibodies ... T Shaw, J Quan, and M Totoritis, "B cell therapy for rheumatoid arthritis: the rituximab (anti-CD20) experience", Ann Rheum Dis ...
ofatumumab (HuMax-CD20) a fully human B cell-depleting agent.[55]. *Third-generation anti-CD20s such as obinutuzumab have a ... chronic inflammatory demyelinating polyneuropathy and autoimmune anemias.[16] The most dangerous, although among the most rare ... Other anti-CD20 monoclonalsEdit. The efficacy and success of Rituximab has led to some other anti-CD20 monoclonal antibodies ... The use of rituximab has not been proven to be efficacious in this setting and like all depleting agents, carries with it the ...
The company's anti-open-source sentiment was enforced by former CEO Steve Ballmer, who referred to Linux, a widely-used open- ... What is essentially the intellectual gift giving of talented programmers challenges the "self-interested-economic-agent ... the discussion forums of open-source projects the topic of gender diversity can be highly controversial and even inflammatory.[ ...
Pain associated with Lyme disease may be treated with nonsteroidal anti-inflammatory drugs (NSAIDs).[30] Corticosteroid joint ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... "Anti-vaxxers stopped the last Lyme disease vaccine. The FDA has just fast-tracked a new one". Newsweek. 25 July 2017. Archived ... The host inflammatory response to the bacteria in the skin causes the characteristic circular EM lesion.[61] Neutrophils, ...
... nephrotoxins like radiologic contrast and non-steroidal anti-inflammatory drugs), antihypertensives, diet and weight ... Commonly used agents are prednisone, mycophenolate, cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and ... An erythropoetin stimulating agent may be required to ensure adequate production of red blood cells, activated vitamin D ... Auto-immune and inflammatory kidney disease, such as vasculitis or transplant rejection, may be treated with immunosuppression ...
This was shown when the anti-hyperalgesic action was reduced when administered in α2 and α3 mice in inflammatory pain and in ... Sedative actions of benzodiazepines limit their usefulness as analgesic agents and they are therefore generally not considered ... Additionally, studies in α5 mice showed that the spinal α5-containing GABAA receptor has a minor role in inflammatory pain. An ... Although barbiturates fell out of favor, they continue to serve as a short-acting anesthetic and anti-epileptic drugs. ...
... which are believed to be involved in the pathophysiology of major depression and stimulates the release of anti-inflammatory ... Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... Moclobemide also has neuroprotective properties in its demonstrated anti-hypoxia or anti-ischemia effects; there is a ... moclobemide has been recommended as a first line agent for the treatment of depression in the elderly.[55] Due to the side ...
... an anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity". International ... It is also used as a mild laxative and is anti-inflammatory[13] and bactericidal.[14] ...
It is the causative agent of Johne's disease, which affects ruminants such as cattle, and suspected causative agent in human ... "Inflammatory Bowel Diseases. 11 (8): 782-3. doi:10.1097/01.MIB.0000179317.27132.24. PMID 16043998. Archived from the original ... Professor John Hermon-Taylor of Kings College London is developing a new vector type anti MAP vaccine which he claims is both ... It has long been suspected as a causative agent in Crohn's disease in humans,[4][5] but studies have been unable to show ...
He argued that journalists who urged the government to pass anti-discrimination laws were "of the same kidney and sometimes on ... agreed with his inflammatory call for the repatriation of non-whites already resident in Britain.[32] ... the disgruntled and the agent provocateur the power to pillory them for their private actions.[9] ... 83 per cent now felt immigration should be restricted (75 per cent before the speech) and 65 per cent favoured anti- ...
... long-acting agents are recommended.[2] Long-acting agents partly work by reducing hyperinflation.[74] If long-acting ... Chronic bacterial infections may also add to this inflammatory state.[68] The inflammatory cells involved include neutrophil ... and act as anti-inflammatories. They show promise in decreasing the rate of exacerbations, but do not appear to change a ... External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. ...
These include β2-agonists, dopamine, insulin, allopurinol, and non-steroidal anti-inflammatory drugs (NSAIDs), such as ... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ... These agents are less likely to produce early warning signs (phosgene in low concentrations has a pleasant odor), are more ...
April 22, 1988 Anti-Acne Drug Faulted in Birth *^ CDC. January 21, 2000 Accutane®-Exposed Pregnancies -- California, 1999 MMWR ... Several trials over inflammatory bowel disease claims have been held in the United States thus far, with many of them resulting ... The drug is associated with inflammatory bowel disease (IBD)-ulcerative colitis, but not Crohn's disease.[51] There are also ... "Isotretinoin use and the risk of inflammatory bowel disease: a case-control study". The American Journal of Gastroenterology ...
... a new anti-inflammatory metalloprotein drug evaluation of clinical efficacy and safety in inflammatory conditions of the ... An SOD-mimetic agent, TEMPOL, is currently in clinical trials for radioprotection and to prevent radiation-induced dermatitis.[ ... or as the veterinary anti-inflammatory drug "Orgotein".[4] Likewise, Brewer (1967) identified a protein that later became known ... Therefore, such antioxidants may be important new therapies for the treatment of inflammatory bowel disease.[45] ...
Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ... Corneal ulcer is an inflammatory or more seriously, infective condition of the cornea involving disruption of its epithelial ... These infectious agents produce proteases and collagenases which break down the corneal stroma. Complete loss of the stroma can ... However, larger or deeper ulcers often require the presence of blood vessels to supply inflammatory cells. White blood cells ...
Aronson, edited by Jeffrey K. (2008). Meyler's side effects of analgesics and anti-inflammatory drugs. Amsterdam: Elsevier ... "Antimicrobial agents for treating uncomplicated urinary tract infection in women". Cochrane Database of Systematic Reviews. 10 ... Vulvovaginitis, urethritis, pelvic inflammatory disease, interstitial cystitis[5]. Treatment. Antibiotics (nitrofurantoin or ... Methenamine is another agent used for this purpose as in the bladder where the acidity is low it produces formaldehyde to which ...
Due to its role in generating the activated form of NF-κB, an anti-apoptotic and pro-inflammatory regulator of cytokine ... is the first proteasome inhibitor to reach clinical use as a chemotherapy agent.[102] Bortezomib is used in the treatment of ... Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor cell types such as hepatocellular carcinoma.[81 ... Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G (November 2006). "Heat shock proteins 27 and 70: anti-apoptotic ...
The motor arc of the inflammatory reflex is termed the cholinergic anti-inflammatory pathway. ... helps remove infectious agents.[2] Also, mucus traps infectious agents.[2] The gut flora can prevent the colonization of ... The inflammatory response is characterized by the following symptoms: *redness of the skin, due to locally increased blood ... The inflammatory reflex is a prototypical neural circuit that controls cytokine production in the spleen.[13] Action potentials ...
A number of common microfungi are important agents of post-harvest spoilage, notably members of the genera Aspergillus, ... Expert Rev Anti Infect Ther. 8 (8): 957-64. doi:10.1586/eri.10.72. PMID 20695750.. ... and occupy damp or moldy buildings are at an increased risk of health problems such as inflammatory and toxic responses to mold ... "Housing interventions and control of asthma-related indoor biologic agents: a review of the evidence". J Public Health Manag ...
Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma»։ The Cochrane ... Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the ... 16,0 16,1 16,2 16,3 16,4 Scott J. P., Peters-Golden M. (September 2013)։ «Antileukotriene agents for the treatment of lung ... Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma»։ The Cochrane ...
Stewart JM (2003). "Bradykinin antagonists as anti-cancer agents". Current Pharmaceutical Design. 9 (25): 2036-42. doi:10.2174/ ... Bradykinin is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge), and therefore causes ... and bradykinin antagonists have been investigated as anti-cancer agents.[19] See also[edit]. *Hypotensive transfusion reaction ... On the basis of this finding, Squibb scientists developed the first of a new generation of highly-effective anti-hypertensive ...
Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of ... Wu H, Zhang Z, Li Y, Zhao R, Li H, Song Y, Qi J, Wang J (Oct 2010). "Time course of upregulation of inflammatory mediators in ... SCH-530,348 SCH530348 has been recently shown to attenuate the neutrophilic inflammatory response to Streptococcus pneumoniae ... which is important in the pathogenesis of inflammatory and fibrotic lung diseases. It is involved both in disruption and ...
... should be given to possibility of strep species as cause that are still sensitive to traditional anti-staphylococcus agents ... Perianal abscesses can be seen in patients with for example inflammatory bowel disease (such as Crohn's disease) or diabetes. ... In those cases of abscess which do require antibiotic treatment, Staphylococcus aureus bacteria is a common cause and an anti- ... The cytokines trigger an inflammatory response, which draws large numbers of white blood cells to the area and increases the ...
"Antimicrobial Agents and Chemotherapy. 38 (8): 1864-67. doi:10.1128/aac.38.8.1864. PMC 284652. PMID 7986023.. ... Wilson JC, von Itzstein M (July 2003). "Recent strategies in the search for new anti-influenza therapies". Current Drug Targets ... so symptoms are not entirely due to the inflammatory response.[98] This massive immune response might produce a life- ... The first influenza virus to be isolated was from poultry, when in 1901 the agent causing a disease called "fowl plague" was ...
In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... Anti-inflammatory: NSAIDs, corticosteroids. *Anti-allergy: mast cell inhibitors. *Anti-glaucoma: adrenergic agonists, beta- ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ... anti-allergics, antihistamines, NSAIDs, Corticosteroids For nutritionEdit. Tonics, electrolytes and mineral preparations ( ...
... that act as an anti-nociceptive agent with mild anti-inflammatory activity in mice.[10] These truxillic acids and their ... A Novel Strategy for Development of Anti-Inflammatory and Anti-Nociceptive Drugs". PLoS ONE. 7 (12): e50968. doi:10.1371/ ... derivatives have been known to have anti-inflammatory and anti-nociceptive effects in mice[11] and are active components of a ... The blockade of anandamide transport may, at least in part, be the mechanism through which these compounds exert their anti- ...
Newburg D.S. (2001) Overview: Immunomodulatory and Anti-Inflammatory Agents. In: Newburg D.S. (eds) Bioactive Components of ... More recently, anti-inflammatory components that attenuate the activity of these cellular components, thereby modulating the ... The protective role of human milk is augmented by multifunctional agents such as lactoferrin and free fatty acids that are part ...
... Anu Kajal, Suman Bala, Neha Sharma, Sunil Kamboj, and Vipin ... potential anti-inflammatory agents," Medicinal Chemistry Research, 2013. View at Publisher · View at Google Scholar ... benzamido moiety as antimicrobial and anti-inflammatory agents," Der Pharma Chemica, vol. 3, no. 5, pp. 146-154, 2011. View at ... "Synthesis and biological evaluation of some hydrazone derivatives as anti-inflammatory agents," Letters in Drug Design & ...
anti-inflammatory agents synonyms, anti-inflammatory agents pronunciation, anti-inflammatory agents translation, English ... dictionary definition of anti-inflammatory agents. anti-inflammatory agents. Translations. English: anti-inflammatory agents n ... CNS agents, pulmonary agents, endocrine agents, anti-inflammatory agents, and miscellaneous topics such as agents for obesity, ... anti-inflammatory agents. Also found in: Thesaurus, Medical.. Related to anti-inflammatory agents: Corticosteroids ...
5 Studies found for: Neuroma , Anti-Inflammatory Agents. Also searched for Anti Inflammatories. See Search Details ...
Nonsteroidal anti-inflammatory drugs (NSAIDs). Class Summary. These agents have analgesic and antipyretic activities. Their ... Nonsteroidal anti-inflammatory medications (NSAIDs) are frequently prescribed for this condition; caution patients to watch for ... Corticosteroid agents. Class Summary. A recent report suggested that short-term oral steroids may be beneficial in CTS. ... For relief of mild to moderately severe pain; inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase ...
... is a phototoxic inflammatory dermal reaction induced by exposure to certain light-sensitizing plant products followed by ... exposure to long-wave ultraviolet light (UV-A 320-380 nm). Both components (plant and light) are required; neither agent alone ... Nonsteroidal anti-inflammatory agents. Class Summary. Although most NSAIDs are used primarily for their anti-inflammatory ... These agents have anti-inflammatory properties and cause profound and varied metabolic effects. Corticosteroids modify the ...
View list of generic drugs that are classified under Anti-allergic And Anti-inflammatory Agents along with ICD Code. Find ... Anti-allergic And Anti-inflammatory Agents. ICD Code -Y43.0 Amlexanox This medication is an anti-allergic and anti-inflammatory ... agent, prescribed for aphthous ulcers or canker sores in people with normal immune systems. ...
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anti-Ulcer Agents : CK(213) : AC(84), ... Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Anti-metastatic : CK(634) : AC(414), Interleukin-6 ... Some Example Abstracts on Anti-Inflammatory Agents. The present review explores the potential anti-metastatic mechanisms of ... 452 Curated Medical Research astracts associated with Anti-Inflammatory Agents. FRIEND membership. $8 / month $75 / year FRIEND ...
Anti-Inflammatory & Anti-Allergy Agents is now published as Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry ( ... Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents. ISSN 1568-0142 (Print) Visit publication homepage ...
Indomethacin: A New Non-steroid Anti-inflammatory Agent Br Med J 1963; 2 :965 doi:10.1136/bmj.2.5363.965 ... Indomethacin: A New Non-steroid Anti-inflammatory Agent. Br Med J 1963; 2 doi: https://doi.org/10.1136/bmj.2.5363.965 ( ...
Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729). Additional Keywords : Anti-Inflammatory Agents, ... Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729). Additional Keywords : Anti-Inflammatory Agents, ... Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729). Additional Keywords : Anti-Inflammatory Agents, ... Pharmacological Actions : Anti-Inflammatory Agents : CK(12461) : AC(4729). Additional Keywords : Anti-Inflammatory Agents, ...
... Ji Qi,1 C. K. Tan,1 Saeed M. Hashimi ... "Toad Glandular Secretions and Skin Extractions as Anti-Inflammatory and Anticancer Agents," Evidence-Based Complementary and ...
"Melatonin as a new possible anti-inflammatory agent," Journal of Biological Regulators and Homeostatic Agents, vol. 11, pp. 157 ... Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation. Gaia Favero,1 Lorenzo Franceschetti,1 Francesca ... Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti- ... Experimental evidence suggests that melatonin exerts its anti-inflammatory effects by modulating both pro- and anti- ...
View list of generic drugs that are Therapeutically classified under Antiasthmatic agent and anti-inflammatory agent. Find ... Antiasthmatic Agent And Anti-inflammatory Agent - Drugs. On Medindia find the complete list of Antiasthmatic Agent And Anti- ... inflammatory Agent drugs with their available forms and strength. More information is available on each drug including their ...
... April 3, 2006. by Gloria Tsang Leave a Comment ... The author of this study suggested that Vitamin D3 may serve as a new anti-inflammatory agent for treatment of congestive heart ... After 9 months of supplementation, significantly higher levels of the anti-inflammatory agent, cytokine interleukin 10, were ... German researchers investigated the anti-inflammatory property of Vitamin D in over 100 patients with congestive heart failure ...
The anti-inflammatory components in breast milk are those bioactive substances that confer or increase the anti-inflammatory ...
They are now considered major actors in many chronic inflammatory diseases. However, no major drug focusing on this target is ... Inflammasomes are a family of proteins in charge of the initiation of inflammatory process during innate immune response. ... tremors and pain are efficaciously controlled by anti-inflammatory agents acting on the secondary steps of inflammatory ... This compound has antioxidant properties [37] and was recently described as an anti-inflammatory agent with direct effects on ...
The inventive pharmaceutical composition comprises a combination of tenatoprazole and one or more anti-inflammatory agents ... 2. The method of claim 1, wherein the anti-inflammatory agent is a nonsteroidal anti-inflammatory agent or a cyclooxygenase-2 ( ... The method of claim 11, wherein the anti-inflammatory agent is a nonsteroidal anti-inflammatory agent or a cyclooxygenase-2 ( ... a combination of tenatoprazole and one or more anti-inflammatory agents selected from non-steroid anti-inflammatory agents and ...
... began a Phase I clinical trial of a new inflammatory disease agent - the first compound to enter the clinic resulting from a ... began a Phase I clinical trial of a new inflammatory disease agent - the first compound to enter the clinic resulting from a ...
The impact of nonsteroidal anti-inflammatory drugs on blood pressure, with an emphasis on newer agents.. Armstrong EP1, Malone ... Both nonselective and selective nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to increase blood pressure (BP ...
This article is a literature review of the biochemical pathways of inflammatory pain, the potentially serious side effects of ... nonsteroidal drugs and commonly used and clinically studied natural alternative anti-inflammatory supplements. Although ... Natural anti-inflammatory agents for pain relief. Home/Pain Relief/Natural anti-inflammatory agents for pain relief ...
... anti-HIV, cardiovascular, local anaesthetic, anti-inflammatory, anticonvulsant and anti-diabetic. The therapeutic properties of ... An update on Anti-inflammatory Compounds: A Review by Ashwani Kumar Dhingra, Bhawna Chopra, Rameshwar Dass, Sanjeev Kumar ... An effective anti-inflammatory drug should be able to inhibit the development of inflammation without interfering in normal ... Anti-inflammatory studies showed statistically significant activity when compared to the control, indomethacin. The two most ...
The results showed that these analogs were superior to resveratrol in 1) anti-angiogenesis in vitro, 2) nitric oxide inhibition ... Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents () ... Synthesis and bioevaluation of novel heterostilbenes as potential anti-inflammatory and anti-angiogenic agents. Modern Research ... Pettit, G.R., Grealish, M.P., Jung, M.K., Hamel, E., Pettit, R K., Chapuis, J.C. and Schmidt, J.M. (2002) Antineoplastic agents ...
... discusses the use of anti-inflammatory agents in treating patients with bipolar disorder. ... QUESTION: Have anti-inflammatory agents been studied in treating bipolar depression? ANSWER: An excellent question. Both ... A recent meta-analysis found only a moderate benefit in adjunct use of varied anti-inflammatory strategies (nonsteroidal agents ... So, when everything is said and done, should we deploy anti-inflammatory strategies in the treatment of bipolar illness? ...
These results indicate that polarization of human iNKT cell responses to Th2-like or anti-inflammatory effects may best be ...
Inflammatory cells play important roles in tumor progression. Various immune cells including tumor-associated neutrophils, ... investigations and basic research using human immune cells or mouse models have revealed that non-steroidal anti-inflammatory ... Further basic studies examining the relationship between the inflammatory process and prostate cancer progression are warranted ... Main Inflammatory Cells and Potentials of Anti-Inflammatory Agents in Prostate Cancer ...
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes ... Anti-Inflammatory & Anti-Allergy Agents was launched in 2002 and later renamed in 2006 as Anti-Inflammatory & Anti-Allergy ... Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Anti-Inflammatory and ... Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in ...
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes ... Anti-Inflammatory & Anti-Allergy Agents was launched in 2002 and later renamed in 2006 as Anti-Inflammatory & Anti-Allergy ... Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Anti-Inflammatory and ... Anti-Allergy Agents. Volume 19, 4 Issues, 2020. ISSN: 1875-614X (Online). ISSN: 1871-5230 (Print). This journal supports open ...
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes ... Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, Volume 14. * Anti-Inflammatory & Anti-Allergy Agents in ... Anti-Inflammatory & Anti-Allergy Agents was launched in 2002 and later renamed in 2006 as Anti-Inflammatory & Anti-Allergy ... Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Anti-Inflammatory and ...
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes ... Anti-Inflammatory & Anti-Allergy Agents was launched in 2002 and later renamed in 2006 as Anti-Inflammatory & Anti-Allergy ... Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. Formerly: Current Medicinal Chemistry - Anti-Inflammatory and ... Tunctan was the Editor-in-Chief of this journal (Anti-Inflammatory and Anti-Allergy Agent in Medicinal Chemistry) (2004-2015), ...
  • Although most NSAIDs are used primarily for their anti-inflammatory effects, they are effective analgesics and are useful for the relief of mild to moderate pain. (medscape.com)
  • Both nonselective and selective nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to increase blood pressure (BP). (nih.gov)
  • Non-steroidal anti-inflammatory drugs (NSAIDs) exert their effects by inhibition of prostaglandin production. (nih.gov)
  • To determine whether race is a predictor of a patient's likelihood of being prescribed selective cyclooxygenase-2 inhibitors (COX-2s) versus other nonsteroidal anti-inflammatory agents (NSAIDs) in Medicaid managed care plans (MCO). (wiley.com)
  • Considerable effort has been devoted to the discovery of non-steroidal anti-inflammatory drugs ("NSAIDs") with reduced undesirable effects in the gastrointestinal ("GI") tract and the kidney, for example. (google.com)
  • Nonsteroidal Anti-inflammatory Agents (NSAIDs) accounted for the highest share of the market in 2015, which can be credited to highest penetration, higher demand due to low cost, and efficient pain relief. (researchandmarkets.com)
  • NSAIDs, colchicine, and corticosteroids are majorly used to treat acute gout, and urate-lowering agents are utilized in chronic gout treatment in combination with NSAIDs or Colchicine. (researchandmarkets.com)
  • Steroidal and nonsteroidal antiinflammatory drugs (NSAIDs), which are inhibitors of arachidonic acid (AA) pathway, both limit fibroblast activity and reduce inflammation. (arvojournals.org)
  • These results suggest that NSAIDs may be useful as both antiinflammatory and antiproliferative agents in preventing bleb failure after GFS. (arvojournals.org)
  • Inhibitors of the microsomal prostaglandin E(2) synthase-1 as alternative to non steroidal anti-inflammatory drugs (NSAIDs)--a critical review. (semanticscholar.org)
  • These include corticosteroids, high dose non-steroidal anti inflammatory drugs (NSAIDs), macrolides and possibly leukotriene antagonists. (cfmedicine.com)
  • This chapter describes the nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat inflammation, pain, and fever and the drugs used for hyperuricemia and gout. (mhmedical.com)
  • Tried or prescribed Nonsteroidal Anti-inflammatory Agents (NSAIDs) for Carpal Tunnel Syndrome? (foundhealth.com)
  • Read more details about Nonsteroidal Anti-inflammatory Agents (NSAIDs) . (foundhealth.com)
  • The present article primarily reviews recent evidence about the most advantageous antibiotic regimen to minimize endophthalmitis, and the utility of steroids or nonsteroidal anti-inflammatory drugs (NSAIDs) in management of both postoperative inflammation and cystoid macular edema. (blogspot.com)
  • Other studies demonstrate the anti-inflammatory effect of multiple perioperative topical NSAIDs. (blogspot.com)
  • New evidence clarifies the use of intracameral antibiotics, and other studies support a niche anti-inflammatory role for NSAIDs. (blogspot.com)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) alleviate pain by counteracting the cyclooxygenase (COX) enzyme. (wikipedia.org)
  • This 100% natural remedy combines two highly effective anti-inflammatory agents that work to reduce inflammation and swelling. (thefreedictionary.com)
  • The first step of inflammation is the production of the pro-inflammatory cytokines Interleukin-1β (IL-1β) and interleukin-18 (IL-18) and the immunoregulatory cytokines type 1 interferon-α and β (INFα and INFγ) when PAMPs are externally recognized. (mdpi.com)
  • 9. The method of claim 1, wherein the inflammatory disease is a rheumatic inflammation. (freepatentsonline.com)
  • 10. A method of treating pain and/or inflammation while avoiding digestive irritation comprising administering to a subject in need thereof a combination of tenatoprazole and one or more anti-inflammatory agents. (freepatentsonline.com)
  • An effective anti-inflammatory drug should be able to inhibit the development of inflammation without interfering in normal homeostasis. (chemweb.com)
  • Current approaches to overcome the inflammation include the use of immune selective anti-inflammatory derivatives, selective glucocorticoid receptor agonist, resolvins and protectins and TNF inhibitors. (chemweb.com)
  • and COX-2, which is induced by cytokines, mitogens and endotoxins in inflammatory cells, is responsible for the elevated production of prostaglandins during inflammation. (nih.gov)
  • Epidemiological investigations and basic research using human immune cells or mouse models have revealed that non-steroidal anti-inflammatory drugs, metformin, statins, soy isoflavones, and other diets are potential interventions for preventing progression of prostate cancer by suppressing inflammation. (mdpi.com)
  • Most of the studies have reported that chlorhexidine gluconate or essential oils provide significant anti-plaque and anti-septic benefits whereas triclosan represents unique clinical effects on reducing inflammation in addition to inhibiting the dental plaque biofilm. (eurekaselect.com)
  • An emerging body of evidence suggests that inflammation contributes to the development of major depression, but the results of clinical trials using various anti-inflammatory agents to treat the condition have proved inconclusive. (brightsurf.com)
  • These compounds are useful as anti-inflammatory agents in the treatment of inflammation and pain. (google.com)
  • In a study published in the journal BMC Complementary and Alternative Medicine , the leaf extracts of mbola ( Parinari curatellifolia ) an African medicinal plant, has a potent anti-inflammatory activity that can help prevent inflammation from causing further damage to your body . (naturalnews.com)
  • It is also used to fight inflammation, prompting the researchers to confirm if it does, indeed, have anti-inflammatory properties. (naturalnews.com)
  • Our findings suggest that BBB dysfunction induced by chronic ingestion of SFA is reversible with timely introduction and sustained treatment with agents that suppress inflammation. (unboundmedicine.com)
  • Stelios Loukides, Konstantinos Bartziokas, Jorgen Vestbo and Dave Singh, "Novel Anti-Inflammatory Agents in COPD: Targeting Lung and Systemic Inflammation", Current Drug Targets (2013) 14: 235. (eurekaselect.com)
  • The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. (biomedcentral.com)
  • N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. (biomedcentral.com)
  • This idea was in accordance with the view that chronic inflammation contributes to Alzheimer's disease, and drew attention to the therapeutic potential of anti-inflammatory drugs for the treatment of Abeta-elicited CAA. (inserm.fr)
  • Both compounds inhibit the bacterial endotoxin-induced maturation and migration of monocyte-derived dendritic cells (MoDCs), thereby prevending sustained and excessive inflammatory responses, which otherwise contribute to chronic inflammation and delayed wound healing. (ascenion.de)
  • During inflammation, enhanced vascular permeability coupled with migration of blood corpuscles into the inflammatory site/s causes oedema, erythema and pain. (biomedcentral.com)
  • Various inflammatory mediators, namely nitric oxide (NO), prostaglandin-2 (PGE-2), interleukins (ILs) and tumor necrosis factor (TNF-α) play an imperative role during the progress of inflammation [ 2 ]. (biomedcentral.com)
  • Inflammation is the local defensive response of living tissues to injury or due to any other chemical agents. (ijpsr.com)
  • Inflammation consists of two basic processes early inflammatory response later followed by healing. (ijpsr.com)
  • Animal models of inflammation are used to study pathogenesis of ailments and to evaluate potential anti-inflammatory drugs for clinical use. (ijpsr.com)
  • Inflammation is normal and necessary protective response to the harmful stimuli such as infectious agents, antigen-antibody reactions, thermal, chemical, physical agents, and ischemia 1, 2 . (ijpsr.com)
  • Inflammation cascades can lead to the development of diseases such as chronic asthma, arthritis, multiple sclerosis, inflammatory bowel disease, and psoriasis 3 . (ijpsr.com)
  • Prolonged or chronic inflammation leads to a progressive shift in the type of cells present at the site of inflammation and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process. (blogspot.gr)
  • Further evidence that inflammation may cause diabetes comes from studies suggesting that aspirin and other anti-inflammatory agents can reverse insulin resistance in mice, rats, and people, says Steven E. (freethesaurus.com)
  • Atherosclerosis-related inflammation is mediated by a complex cocktail of pro-inflammatory cytokines, chemokines, bioactive lipids, and adhesion molecules, and blocking the key pro-atherogenic inflammatory mechanisms can be beneficial for treatment of atherosclerosis. (inat.ru)
  • Neutrophils stimulate pro-inflammatory cytokines to maintain inflammatory response and stimulate systemic inflammation in form of fever . (turmericforhealth.com)
  • Use of turmeric for inflammation treats all of these symptoms efficiently in par with the anti-inflammatory drugs. (turmericforhealth.com)
  • Anti-inflammatory is the property of a substance or treatment that reduces inflammation or swelling. (wikipedia.org)
  • Anti-inflammatory drugs also called anti-inflammatories, make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system to block pain signaling to the brain. (wikipedia.org)
  • Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory cytokines. (hindawi.com)
  • Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions. (hindawi.com)
  • The pro-inflammatory cytokines IL-1β and IL-18 are produced under the control of inflammasomes, a family of proteins described for the first time in 2002 [ 1 ]. (mdpi.com)
  • A number of herbal drugs have been identified in the past that can target inflammatory cytokines. (chemweb.com)
  • Both depression and mania have been associated with elevation in the peripheral inflammatory cytokines. (psychcongress.com)
  • While patients who have suffered from bipolar disorder for less than three years show no elevation in inflammatory cytokines relative to healthy controls, there is a robust difference in patients who have had bipolar disorder for longer than 10 years. (psychcongress.com)
  • These findings lend credence to an assumed etiological role of inflammatory cytokines in pathophysiology of bipolar disorder. (psychcongress.com)
  • Prostaglandin E3 also inhibits the synthesis of TNF and IL-1 , both of which are inflammatory cytokines. (prolinesportsnutrition.com)
  • IL-8 was measured with other acute phase cytokines (tumor necrosis factor alpha [TNF-alpha], IL-6 and IL-1 beta) in 25 normal humans randomized to receive either intravenous endotoxin alone or endotoxin after oral administration of ibuprofen or pentoxifylline, agents that alter some of the inflammatory responses induced by endotoxin in vitro. (rupress.org)
  • Differential induction of pro- and anti-inflammatory cytokines in whole blood by bacteria: effects of antibiotic treatment. (asm.org)
  • The most promising anti-inflammatory compounds for treatment of atherosclerosis include non-specific anti-inflammatory drugs, phospholipase inhibitors, blockers of major inflammatory cytokines, leukotrienes, adhesion molecules, and pro-inflammatory signaling pathways, such as CCL2-CCR2 axis or p38 MAPK pathway. (inat.ru)
  • Curcumin inhibits the action of different enzymes , transcription factors, cytokines and adhesion molecules involved in the inflammatory pathway. (turmericforhealth.com)
  • 2. The method of claim 1, wherein the anti-inflammatory agent is a nonsteroidal anti-inflammatory agent or a cyclooxygenase-2 (COX-2) inhibitor. (freepatentsonline.com)
  • 3. The method of claim 2, wherein the nonsteroidal anti-inflammatory agent is selected from the group consisting of aspirin, diclofenac, etodolac, indometacin, naproxen, ibuprofen and piroxicam. (freepatentsonline.com)
  • Famprofazone (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan. (chemchart.com)
  • After 9 months of supplementation, significantly higher levels of the anti-inflammatory agent, cytokine interleukin 10, were found among patients in the Vitamin D group. (healthcastle.com)
  • Furthermore, one study has noted that an increase in a composite inflammatory cytokine measure, comprised of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α), preceded the onset of mania. (psychcongress.com)
  • Additionally, peripheral inflammatory cytokine levels may reflect illness duration. (psychcongress.com)
  • Minocycline, a tetracyclic antibiotic, has been shown to prevent inflammatory cytokine release and microglial activation in the CNS. (psychcongress.com)
  • Radiculopathy, a painful neuroinflammation that can accompany intervertebral disc herniation, is associated with locally increased levels of the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα). (duke.edu)
  • This leads to the nuclear translocation of the p50- p65 subunits of NF-κB, and further triggers pro-inflammatory cytokine gene expression. (eur.nl)
  • Altered cytokine responses caused by antiinflammatory therapy may have important implications for both host defense and injury during septicemia. (rupress.org)
  • These differences were less pronounced for the anti-inflammatory cytokine IL-1ra. (asm.org)
  • Animal experimentation and cocoa interventions in humans support the anti-inflammatory effect of cocoa compounds. (greenmedinfo.com)
  • An update on Anti-inflammatory Compounds: A Review by Ashwani Kumar Dhingra, Bhawna Chopra, Rameshwar Dass, Sanjeev Kumar Mittal (81-97) . (chemweb.com)
  • Compounds 7-12 and 18-23 showed good anti-inflammatory activity compared to a standard drug, indomethacin. (rsc.org)
  • The preliminary structure-activity relationship revealed that tryptophan, tyrosine, phenylalanine, proline and cysteine conjugated compounds showed excellent antimicrobial and anti-inflammatory activities. (rsc.org)
  • Molecular docking studies were performed for all the synthesised compounds, among which compounds 20 , 21 and 23 showed the highest docking scores for antimicrobial activity while compounds 9 , 20 and 22 showed the highest docking scores for anti-inflammatory activity. (rsc.org)
  • The results demonstrated that the compounds 3b, 4b, and 5b could serve as gastroprotective lead compounds for developing a novel class of potent as well as orally active anti-inflammatory and analgesic agents in the future research. (omicsonline.org)
  • These findings emphasize and validate the previous work of others and identify the most effective CAM anti-inflammatory, antibacterial compounds using these models. (biomedcentral.com)
  • The new compounds were evaluated for their antioxidant activity and for their ability to inhibit in vitro lipoxygenase as well as for their anti-inflammatory activity in vivo. (figshare.com)
  • In addition, the Company has other clinical and preclinical anti-inflammatory compounds, including AGI-1096, an oral agent for the prevention of organ transplant rejection. (marketwired.com)
  • All synthesized new compounds 1-9 along with compound III as a parent compound and Celecoxib as a reference, were assessed for their anti-inflammatory activity both in-vivo and in-vitro using the formalin-induced hind paw edema method and inhibition of albumin denaturation and red blood cells (RBCs) membrane stabilization, respectively. (readbyqxmd.com)
  • Both compounds possess antimicrobial and anti-inflammatory activity and are capable of efficiently neutralizing bacterial endotoxins. (ascenion.de)
  • Our lead compounds were then screened for anti-inflammatory activity. (elsevier.com)
  • Andrographolide might be useful as a treatment for various inflammatory diseases. (greenmedinfo.com)
  • Baicalein could be a lead compound for the modulation of inflammatory diseases as well as certain cancers. (greenmedinfo.com)
  • They are now considered major actors in many chronic inflammatory diseases. (mdpi.com)
  • Inflammasomes were initially reported for their role in rather marginal or quite benign pathologies such as periodic fevers and gout but are now considered key actors in many chronic inflammatory diseases. (mdpi.com)
  • His clinical and research interests particularly concern on the regulation of both the mucosal and systemic inflammatory responses in relation to gastrointestinal diseases and the development of novel anti-inflammatory strategies. (benthamscience.com)
  • Mechanical plaque control is the primary tool to prevent the progression of periodontal diseases, but adjunctive usage of anti-inflammatory mouth-rinses can be necessary for certain time periods for certain category of patients. (eurekaselect.com)
  • Although nitric oxide plays an important role in maintaining proper cardiovascular function, mainly because of its ability to lower blood pressure by relaxing and dilating your blood vessels, it is a pro-inflammatory chemical that contributes to the progression of inflammatory diseases. (naturalnews.com)
  • Thus, in the need of a more effective therapy for the treatment of inflammatory diseases, specific inhibition of IKKβ represents a rational alternative strategy to the current therapies. (eur.nl)
  • Global health initiatives are encumbered by a vast majority of the population suffering from non-communicable inflammatory diseases such as cardiovascular disease, neurodegeneration, diabetes, arthritis, ulcerative colitis/bowel disease and cancer. (biomedcentral.com)
  • AtheroGenics is focused on the discovery, development and commercialization of potential drug candidates for the treatment of chronic inflammatory diseases, including diabetes and coronary heart disease (atherosclerosis). (marketwired.com)
  • In the chronic state of inflammatory diseases, cellular signaling networks aimed at combating invading pathogens are often constitutively active and transmit their signals even in the absence of inflammatory agents. (semanticscholar.org)
  • Effect of antisecretory drugs and nitrates on the risk of ulcer bleeding associated with nonsteroidal anti-inflammatory drugs, antiplatelet agents, and anticoagulants," The American Journal of Gastroenterology , vol. 102, no. 3, pp. 507-515, 2007. (hindawi.com)
  • Useful measures include anti-inflammatory drugs and depigmenting agents. (medscape.com)
  • On Medindia find the complete list of Antiasthmatic Agent And Anti-inflammatory Agent drugs with their available forms and strength. (medindia.net)
  • The impact of nonsteroidal anti-inflammatory drugs on blood pressure, with an emphasis on newer agents. (nih.gov)
  • This article is a literature review of the biochemical pathways of inflammatory pain, the potentially serious side effects of nonsteroidal drugs and commonly used and clinically studied natural alternative anti-inflammatory supplements. (chiro.org)
  • Nur Balci and Nurcan Buduneli, "Anti-Inflammatory Agents in Mouth-Rinses For Periodontal Treatment", Clinical Anti-Inflammatory & Anti-Allergy Drugs (Discontinued) (2015) 2: 14. (eurekaselect.com)
  • Several studies have identified use of non-steroidal-anti-inflammatory drugs and statins for prevention of dementia, but their efficacy in slowing progression is not well understood. (unboundmedicine.com)
  • Expected entry of various new drugs, increasing adoption of drugs, and growing investment by key players for development of these agents are likely to drive the segment. (researchandmarkets.com)
  • Anti-inflammatory drugs might compensate this propensity. (eur.nl)
  • Inhibition activity of 8 synthetic molecules known as anti-allergy drugs on lipases have been investigated. (readbyqxmd.com)
  • Therefore, there is crucial need to search potent and safer molecules as elastase inhibitors and to develop better anti-inflammatory drugs in future. (readbyqxmd.com)
  • Due to side effects of Non Steroidal anti-inflammatory drugs (NSAID), an attempt was made to identify novel tetrasubstituted thiophene lead compound as potential anti-inflammatory and antioxidant agent. (readbyqxmd.com)
  • It is possible to reduce the excessive inflammatory response with a variety of drugs. (cfmedicine.com)
  • Thus, many anti-inflammatory drugs interfere with these dys- and hyperactivated cellular signaling networks or transcription factors. (semanticscholar.org)
  • 2018) Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation. (ascenion.de)
  • Significance and Impact of the Study: Such findings may indicate parallel administration of anti-inflammatory and anti listeriosis drugs. (elsevier.com)
  • Among these detrimental factors, neuroinflammation has been highlighted by epidemiologic studies suggesting that use of anti-inflammatory drugs could significantly reduce the incidence of AD. (edu.au)
  • In addition, we depict putative therapeutic capacity of anti-inflammatory drugs for AD prevention or treatment. (edu.au)
  • We also discuss pathogenic mechanisms by which astrocytes, microglia, T cells and microRNA participate in AD and the neuroprotective mechanisms of anti-inflammatory drugs. (edu.au)
  • Serious adverse effects of most of commercially available anti-inflammatory drugs largely encourage the development of new, target specific and less toxic anti-inflammatory agents from plants [ 7 ]. (biomedcentral.com)
  • Association of Aspirin and Other Nonsteroidal Anti - inflammatory Drugs With Vertebral Trabecular Bone: Data From Multiethnic Study of Atherosclerosis, a Population-Based Multicenter Cohort Study. (wroc.pl)
  • Non-steroidal anti-inflammatory drugs and steroids are often the standard treatment for chronic inflammatory conditions, but these drugs can cause health issues of their own if used for extended periods of time as well as side effects like gastric ulceration and, infrequently, myocardial infarction and stroke. (blogspot.gr)
  • Morria Biopharmaceuticals Plc is a biopharmaceutical company focusing on the development of anti-inflammatory agents termed Multi-Functional Anti-Inflammatory Drugs (MFAID). (freethesaurus.com)
  • Ongoing studies attempt evaluating therapeutic utility of these anti-inflammatory drugs for treatment of atherosclerosis. (inat.ru)
  • On the other hand, there are analgesics that are commonly associated with anti-inflammatory drugs but that have no anti-inflammatory effects. (wikipedia.org)
  • The inventive pharmaceutical composition comprises a combination of tenatoprazole and one or more anti-inflammatory agents selected from non-steroid anti-inflammatory agents and cyclooxygenase-2 inhibitors. (freepatentsonline.com)
  • EP Application No. 91310784.3 describes a class of 5-lipoxygenase inhibitors that are useful as anti-inflammatory agents. (google.com)
  • The first approach is phosphodiesterase inhibitors, such as roflumilast which provides additional clinical benefit either as a single agent or as an additive treatment to long-acting bronchodilators. (eurekaselect.com)
  • Novel leukotriene biosynthesis inhibitors (2012-2016) as anti-inflammatory agents. (semanticscholar.org)
  • Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents , neurotrophic factors, metal ion chelators, ion channel modulators and gene therapy. (freethesaurus.com)
  • Antileukotrines are anti-inflammatory agents which function as leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists (cysteinyl leukotriene receptors) and consequently oppose the function of these inflammatory mediators. (wikipedia.org)
  • These pathways include several molecular targets that are up-regulated in acute lung injury and down-regulated by anti-inflammatory and immunomodulatory agents, including statins, fibrates, and glitazones. (wiley.com)
  • Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a pooled analysis of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry . (brightsurf.com)
  • The present review explores the potential anti-metastatic mechanisms of curcumin. (greenmedinfo.com)
  • Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin, forestomach, and colon when it is administered during initiation and/or postinitiation stages. (aacrjournals.org)
  • Most studies have shown that curcumin can act as an anti-inflammatory agent and antioxidant 1 2 3 4 . (fitnessguru.com)
  • Curcumin C3 Complex® [curcuma longa L. (rhizome) 64-66:1 extract], anti-caking agent (magnesium stearate), bovine gelatin, BioPerine® (piper fruit 50:1 extract), colors (titanium dioxide, yellow iron oxide, red iron oxide). (fitnessguru.com)
  • Synthesis and evaluation of anti-inflammatory and analgesic activity of 3-[(5-substituted-1,3,4-oxadiazol-2-yl-thio)acetyl]-2 H -chromen-2-ones," Medicinal Chemistry Research , vol. 21, no. 1, pp. 16-26, 2012. (hindawi.com)
  • Thiosemicarbazones derived from 1-indanones as new anti- Trypanosoma cruzi agents," Bioorganic & Medicinal Chemistry , vol. 19, no. 22, pp. 6818-6826, 2011. (hindawi.com)
  • Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents is now published as Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents) . (ingentaconnect.com)
  • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new anti-inflammatory & anti-allergy agents. (benthamscience.com)
  • Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field. (benthamscience.com)
  • Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents was launched in 2002 and later renamed in 2006 as Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. (benthamscience.com)
  • Dr. Tunctan was the Editor-in-Chief of this journal (Anti-Inflammatory and Anti-Allergy Agent in Medicinal Chemistry) (2004-2015), published by Bentham Science Publishers. (benthamscience.com)
  • All the synthesized analogues ( 2-23 ) were screened for their in vitro antimicrobial and anti-inflammatory activities. (rsc.org)
  • Newburg D.S. (2001) Overview: Immunomodulatory and Anti-Inflammatory Agents. (springer.com)
  • Assessments of Immunomodulatory and Inflammatory effects against Induction of Entamoeba histolytica (HM1 IMS strain) crude extract Antigen in Complete Freund's Adjuvant Induced Rheumatoid Arthritis Female Wistar Rats by Swati Bagde, Vinod Singh (113-127) . (chemweb.com)
  • It is probably best known for its antibiotic properties, but it also has important antibacterial, antiviral, antifungal, anti-inflammatory, anti-cancer and immunomodulatory effects. (blogspot.gr)
  • inhibits inflammatory reactions and pain by decreasing activity of cyclooxygenase, which is responsible for prostaglandin synthesis. (medscape.com)
  • Inhibits inflammatory reactions and pain by decreasing prostaglandin synthesis. (medscape.com)
  • These results demonstrate that chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of chamomile as an effective anti-inflammatory agent. (spandidos-publications.com)
  • A natural antiinflammatory agent, prostaglandin E3 competitively inhibits the effects of the arachidonic acid conversion to prostaglandin E2, a highly inflammatory substance. (prolinesportsnutrition.com)
  • It also inhibits NF-kB, thus producing an anti-inflammatory effect. (blogspot.gr)
  • Based on these results, it is concluded that roxithromycin is active in reducing the acute inflammatory reaction in rat models through mechanisms different from conventional nonsteroidal antiinflammatory agents such as indomethacin. (nih.gov)
  • Exposure of human breast cancer cells to the anti-inflammatory agent indomethacin alters choline phospholipid metabolites and Nm23 expression. (nih.gov)
  • At the clinical level, inflammatory symptoms such as fevers, tremors and pain are efficaciously controlled by anti-inflammatory agents acting on the secondary steps of inflammatory response. (mdpi.com)
  • UK biotechnology company, Vernalis, received a boost yesterday after it revealed that it was set to benefit from an undisclosed milestone payment after Swiss partner, Serono, began a Phase I clinical trial of a new inflammatory disease agent - the first compound to enter the clinic resulting from a collaboration between the two firms. (pharmatimes.com)
  • The biological basis for the effectiveness of fish oil in treating arthritis has been well documented, with many positive clinical studies when compared with traditional pharmaceutical antiinflammatory agents. (prolinesportsnutrition.com)
  • These findings were presented in a Late Breaking Clinical Study oral presentation entitled, "Delay in Progression to Type 2 Diabetes in Patients with Cardiovascular Disease Treated with a Novel Anti-Inflammatory, Anti-Oxidant, AGI-1067: Evidence from ARISE" [ADA session number LBCS-01], by lead author Jean-Claude Tardif, M.D., ARISE Co-Principal Investigator and Director of Research, Professor of Medicine, Montreal Heart Institute, University of Montreal. (marketwired.com)
  • The Company's lead antioxidant and anti-inflammatory drug candidate, AGI-1067, is being studied in a Phase 3 clinical trial known as ANDES (AGI-1067 as a Novel Anti-Diabetic Agent Evaluation Study), for the treatment of Type 2 diabetes. (marketwired.com)
  • Corticosteroids have a very complex but impressive anti-inflammatory action in a number of clinical situations. (cfmedicine.com)
  • The different animal models (i.e. vascular permeability, UV-erythema in guinea pigs, Croton-oil ear edema in rats and mice, Paw edema in rats, Collagen Induced Arthritis, Adjuvant Induced Arthritis, and Papaya Latex Induced Arthritis) are used for evaluation of anti-inflammatory activity for pre clinical study. (ijpsr.com)
  • Clinical data were recorded in a standardised case report form and analysed for event association with anti-TNF alpha treatment. (qxmd.com)
  • VBL has pioneered the Lecinoxoid class of oral anti-inflammatory agents and VB-201 is the lead candidate from this program, which has entered Phase 2 clinical development in patients with psoriasis. (freethesaurus.com)
  • Therapeutic agents that specifically target some of the atherosclerosis-related inflammatory mechanisms have been evaluated in preclinical and clinical studies. (inat.ru)
  • The results showed that these analogs were superior to resveratrol in 1) anti-angiogenesis in vitro , 2) nitric oxide inhibition in vitro , and 3) inhibition of carrageenan-induced edema in vivo . (scirp.org)
  • It also was the only drug that showed inhibition at the antiinflammatory range in vivo. (arvojournals.org)
  • Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. (semanticscholar.org)
  • article{Schaible2013PotentIO, title={Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin. (semanticscholar.org)
  • Outstanding Anti-inflammatory Potential of Selected Asteraceae Species through the Potent Dual Inhibition of Cyclooxygenase-1 and 5-Lipoxygenase. (semanticscholar.org)
  • The inhibition of cyclooxygenase-2 (COX-2) is thought to mediate, in large part, the antipyretic, analgesic, and anti-inflammatory actions of tNSAIDs, while the simultaneous inhibition of cyclooxygenase-1 (COX-1) largely but not exclusively accounts for unwanted adverse effects in the GI tract. (mhmedical.com)
  • IC possibly produces anti-inflammatory activity through inhibition of TNF-α and NO production. (biomedcentral.com)
  • Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. (bmj.com)
  • Effect of steroids and nonsteroidal antiinflammatory agents on human ocular fibroblast. (arvojournals.org)
  • Sixty-three studies were identified that met the inclusion criteria, including six randomised controlled trials that described the effects of anti-inflammatory agents in combination, rectal steroids alone, rectal sucralfate, short chain fatty acid enemas and different types of thermal therapy. (nature.com)
  • Varasteh recommends, anti-inflammatory agents often are effective in the treatment of pelvic pain. (thefreedictionary.com)
  • These agents have been shown to be useful in the treatment of phytophototoxin plant poisoning. (medscape.com)
  • The author of this study suggested that Vitamin D3 may serve as a new anti-inflammatory agent for treatment of congestive heart failure. (healthcastle.com)
  • The invention is suitable for the treatment of painful and inflammatory manifestations. (freepatentsonline.com)
  • So, when everything is said and done, should we deploy anti-inflammatory strategies in the treatment of bipolar illness? (psychcongress.com)
  • A recent meta-analysis found only a moderate benefit in adjunct use of varied anti-inflammatory strategies (nonsteroidal agents, omega-3 fatty acids, N -acetylcysteine, and pioglitazone) in treatment of bipolar depression. (psychcongress.com)
  • In conclusion, due to a lack of replicated large-scale, longitudinal, randomized controlled trials, adjunct use of anti-inflammatory strategies for treatment of bipolar illness may not be ready for prime-time. (psychcongress.com)
  • And the effects are even stronger when these agents are added on to standard antidepressant treatment, the results show. (brightsurf.com)
  • The researchers therefore set out to review the available evidence and pool the data to see if anti-inflammatory agents work better than dummy (placebo) treatment either alone or when used as add-on therapy to standard antidepressant treatment. (brightsurf.com)
  • The pooled data analysis suggested that anti-inflammatory agents were better than placebo and enhanced the effects of standard antidepressant treatment. (brightsurf.com)
  • And the effects were even greater when one or other of these agents was added to standard antidepressant treatment. (brightsurf.com)
  • The researchers validated mbola's applications in traditional medicine, particularly in pain management and the treatment of inflammatory and tumor-related conditions, such as cancer. (naturalnews.com)
  • Clinically significant improvements in glycemic control were seen over a one year treatment period with AGI-1067 in patients already taking commonly used anti-diabetes medications. (marketwired.com)
  • The unique mechanism of action and encouraging effects on glycemic control with AGI-1067, when used in combination with existing oral anti-diabetic treatments or insulin, support its potential as a future treatment option for patients," said Russell M. Medford, M.D., Ph.D., President and Chief Executive Officer of AtheroGenics. (marketwired.com)
  • Corticosteroid treatment should be considered in patients with CF when other standard therapies have failed to control wheeze, when sputum production remains copious despite appropriate intravenous antibiotic treatment, or when inflammatory markers remain persistently elevated. (cfmedicine.com)
  • A call to all ECCO members was made to report on IBD patients afflicted with CVA during treatment with anti-TNF alpha agents. (qxmd.com)
  • Potential of anti-inflammatory agents for treatment of atherosclerosis. (inat.ru)
  • Benzydamine (also known as Tantum Verde and branded in some countries as Difflam and Septabene), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat. (chemchart.com)
  • Specifically, it is indicated for use in the treatment of steroid-responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye. (chemchart.com)
  • There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. (bmj.com)
  • As non-steroidal anti-inflammatory agents are commonly used and prescribed in emergency departments, it should be kept in mind that an acute dystonic reaction can develop against one of these agents, DKP. (thefreedictionary.com)
  • A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. (bmj.com)
  • METHODS: Two-month-old TGF-beta1 mice and littermate controls were orally administered pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, or ibuprofen, a non steroidal anti-inflammatory agent, for two months. (inserm.fr)
  • A total of nine Listeria monocytogenes strains (seven serotypes) were studied to ascertain whether the non-steroidal anti-inflammatory drug diclofenac (Dc) used in combination with the conventional antilisterial antibiotic gentamicin (Gm) or ampicillin (Am) synergistically augments the efficacy of the antibiotic in vitro. (elsevier.com)
  • Early work in this area demonstrated that the submandibular gland released a host of factors that regulate systemic inflammatory responses and modulate systemic immune and inflammatory reactions. (wikipedia.org)
  • Applied to skin and mucus membranes provides general anti-inflammatory activity via intracellular mechanisms. (medscape.com)
  • Linking human physiology to inflammatory mechanisms discovered in vitro or in animal models is essential to determine their importance. (duke.edu)
  • A third potential approach involves novel agents whose mechanism of action is closely related to COPD mechanisms and pathophysiology. (eurekaselect.com)
  • In this study we investigated the inhibitory effects of chamomile on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and explored its potential anti-inflammatory mechanisms using RAW 264.7 macrophages. (spandidos-publications.com)
  • The obtained results are important for our understanding of atherosclerosis-related inflammatory mechanisms and for designing randomized controlled studies assessing the effect of specific anti-inflammatory strategies on cardiovascular outcomes. (inat.ru)
  • In the present investigation, in order to identify GI-safe anti - inflammatory and analgesic agents, a series of novel 1, 2 and 5-substituted benzimidazole derivatives were synthesized and biologically evaluated. (omicsonline.org)
  • In general, the derivatives were found to be potent antioxidant or anti-inflammatory agents. (figshare.com)
  • The promising activity of coumarin derivatives as anti-inflammatory agents has motivated us to synthesize a new series of coumarin derivatives aiming to improve the anti-inflammatory activity and/or bioavailability. (readbyqxmd.com)
  • A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. (chemchart.com)
  • All isolated prenylated coumarins were assessed for their anti-inflammatory effects together with anti-HIV activities in vitro. (physiciansweekly.com)
  • For robust screening, we developed an in-vitro efficacy paradigm to ensure anti-inflammatory parameters were observed independent of cytotoxicity. (biomedcentral.com)
  • Dutta, NK , Mazumdar, K & Park, JH 2009, ' In vitro synergistic effect of gentamicin with the anti-inflammatory agent diclofenac against Listeria monocytogenes ', Letters in Applied Microbiology , vol. 48, no. 6, pp. 783-785. (elsevier.com)
  • Taken together these results demonstrate that avenanthramides are potent anti-inflammatory agents that appear to mediate the anti-irritant effects of oats. (thefreedictionary.com)
  • These effects may result in analgesic, antipyretic, and anti-inflammatory activities. (medscape.com)
  • These agents have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)
  • Anti-inflammatory effects and chemical study of a flavonoid-enriched fraction from adlay bran. (greenmedinfo.com)
  • This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological conditions and, then, focuses on its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammasome. (hindawi.com)
  • This paper reviews the main agents used in periodontology as a mouth-rinse in regards to anti inflammatory effects and other vehicles to inhibit the growth of supragingival plaque. (eurekaselect.com)
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. (duke.edu)
  • These findings indicate that the isolation and identification of these prenylated coumarins with pronounced anti-inflammatory effects as well as anti-HIV activities separated from the stems of C. lenis could be of great significance to the development of new anti-inflammatory and anti-HIV agents and their potential applications in the pharmaceutical industry. (physiciansweekly.com)
  • From the data available on human subjects treated with Fumaderm, MMF is an effective antipsoriatic agent with known effects on immune cells. (aspetjournals.org)
  • We hypothesized that MMF has direct antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes. (aspetjournals.org)
  • Our results support the notion that MMF has direct antiproliferative, prodifferentiative, and anti-inflammatory effects on keratinocytes, highlighting its potential use as a multifactorial antipsoriatic agent. (aspetjournals.org)
  • We hypothesized that ketamine, via N-methyl D-aspartate receptor blockade and anti-inflammatory effects, would reduce central nervous system injury during cardiopulmonary bypass. (biomedsearch.com)
  • This caution was taken given that many plants exert tumoricidal and anti-inflammatory effects at close range through similar signaling pathways, which could lead to false positives. (biomedcentral.com)
  • It may also slow the progression of multiple sclerosis.Taken orally as an anti-inflammatory, turmeric does not have the side-effects commonly associated with some modern pharmaceutical medicines. (blogspot.gr)
  • It has analgesic, anti-inflammatory, and antipyretic effects. (chemchart.com)
  • One SGP-T derivative is a three-amino acid sequence shown to be a potent anti-inflammatory molecule with systemic effects. (wikipedia.org)
  • Citroflavonoids have also been shown in the literature to be potent antioxidant and anti-inflammatory agents , properties that are also of great interest in skin care. (thefreedictionary.com)
  • A series of N-substituted-quinolinone-3-aminoamides and their hybrids containing the α-lipoic acid functionality were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity. (figshare.com)
  • ocular inflammatory conditions unresponsive to topical corticosteroids. (drugs.com)
  • The anti-inflammatory components in breast milk are those bioactive substances that confer or increase the anti-inflammatory response in a breastfeeding infant. (wikipedia.org)
  • As a natural anti-inflammatory, turmeric aids in giving relief to sufferers of arthritis, osteoarthritis, and rheumatoid arthritis. (blogspot.gr)
  • Ayurveda contains an age-long documented therapeutic use of turmeric as an anti-inflammatory agent. (turmericforhealth.com)
  • These agents have analgesic and antipyretic activities. (medscape.com)
  • it is effective as an antipyretic and analgesic agent at typical doses that partly inhibit COXs. (mhmedical.com)
  • More recently, anti-inflammatory components that attenuate the activity of these cellular components, thereby modulating the immune system of milk and of the infant, have been described. (springer.com)
  • Application of the solvent extraction technique to investigation of the anti-inflammatory activity of adlay bran. (greenmedinfo.com)
  • The antiinflammatory activity of a new 14-membered macrolide antibiotic, roxithromycin, was evaluated in various rat models including carrageenan- and poly-L-arginine-induced hind-paw oedema, croton oil inflamed ear assay and polyester sponge granuloma. (nih.gov)
  • Those who subsequenty die compared to those who survive show significantly higher inflammatory activity as registered by a number of markers (Downey et al, 2007). (cfmedicine.com)
  • The current study aimed to explore the anti-inflammatory activity (in vivo) of a crude ethanolic extract (EE) and the pure identified octadecahydro-picene-2,3,14,15-tetranone (IC) in the root bark of Z. nummularia . (biomedcentral.com)
  • EE (100 and 200 mg/kg, p.o.) and (IC) (400 and 600 μg/kg, p.o.) were subjected to in vivo anti-inflammatory assays to evaluate the anti-inflammatory activity and predict the probable mechanism(s) of action. (biomedcentral.com)
  • Suitable acute (carrageenan-induced paw edema, arachidonic acid-induced ear edema, xylene-induced ear edema) and chronic (cotton pellet granuloma) models were employed to investigate in vivo the anti-inflammatory activity. (biomedcentral.com)
  • Resuming or continuing anti-TNF alpha in IBD patients with CVA may be feasible and safe in selected cases, but careful weighing of IBD activity versus neurological status is prudent. (qxmd.com)
  • They also contain an abundance of omega-3 fatty acids that help reduce the levels of inflammatory markers in your body. (naturalnews.com)
  • AGI-1067 works by selectively inhibiting signaling pathways that are activated in response to oxidative stress and pro-inflammatory stimuli. (marketwired.com)
  • IKKi/IKKepsilon plays a key role in integrating signals induced by pro-inflammatory stimuli. (semanticscholar.org)
  • This study provides an update regarding the efficacy of agents with some anti-inflammatory actions for schizophrenia symptoms tested in randomized controlled trials (RCTs). (eur.nl)
  • Triphala has a promising anti-inflammatory effect in the inflamed paw of arthritis-induced rats. (greenmedinfo.com)
  • Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass: A pilot randomized, double-blind, placebo-controlled trial. (biomedsearch.com)
  • Scientists hope to find neuroprotective agents that will protect against nerve damage. (medicalnewstoday.com)
  • Bioactive prenylated coumarins as potential anti-inflammatory and anti-HIV agents from Clausena lenis. (physiciansweekly.com)
  • Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential. (asm.org)
  • Innate immunity underlies many of these inflammatory responses in health and disease. (duke.edu)
  • Insulin injections into nondiabetic obese people reduced their production of several inflammatory molecules and increased synthesis of certain anti-inflammatory agents , according to tests of blood samples by researchers at the State University of New York at Buffalo. (freethesaurus.com)
  • Ibuprofen, however, functioned as an anti-inflammatory agent, as judged by its ability to inhibit the influx of indium-111-labeled polymorphonuclear leukocytes and chromium-51 ( 51 Cr)-labeled platelets into the ischemic and reperfused heart. (springer.com)
  • The protective role of human milk is augmented by multifunctional agents such as lactoferrin and free fatty acids that are part of the innate immune system of milk and also make major contributions to the nutrition of the infant. (springer.com)
  • This medication is an anti-allergic and anti-inflammatory agent, prescribed for aphthous ulcers or canker sores in people with normal immune systems. (medindia.net)
  • Inflammasomes are a family of proteins in charge of the initiation of inflammatory process during innate immune response. (mdpi.com)
  • These berries help your immune system function properly, increasing your number of natural killer (NK) cells and lowering certain inflammatory markers linked to heart disease. (naturalnews.com)
  • Psoriasis is a common inflammatory hyperproliferative skin disorder that involves cross-talk between different cell types, including immune cells and keratinocytes. (aspetjournals.org)
  • 2016) Synthetic antimicrobial and LPS-neutralising peptides suppress inflammatory and immune repsonses in skin cells and promote keratinocyte migration. (ascenion.de)
  • A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. (blogspot.gr)
  • ImSAIDs work by altering the activation and migration of inflammatory cells, which are immune cells responsible for amplifying the inflammatory response. (wikipedia.org)
  • Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. (pharmacycode.com)
  • Management of inflammatory bowel disease with infliximab and other anti-tumor necrosis factor alpha therapies. (qxmd.com)
  • Development of inflammatory bowel disease during anti-TNF-α therapy for inflammatory rheumatic disease: a nationwide series. (qxmd.com)
  • Outcome after discontinuation of TNFα-blocking therapy in patients with inflammatory bowel disease in deep remission. (qxmd.com)
  • Risk of cerebrovascular accidents and ischemic heart disease in patients with inflammatory bowel disease: a systematic review and meta-analysis. (qxmd.com)
  • Increases in circulating IL-8 are part of the acute inflammatory response of humans to endotoxin. (rupress.org)
  • The poor outcome in patients with Bcc infection may reflect an excessive inflammatory response. (cfmedicine.com)
  • Initially only local ointments and creams containing antifungal agents may be prescribed. (news-medical.net)
  • If the infection is severe or recurs oral antifungal agents may be needed. (news-medical.net)
  • Along with an antifungal an anti-inflammatory agent or steroid cream hydrocortisone may be advised. (news-medical.net)
  • Abstract Despite the best efforts of influenza scientists, companies and health officials to prepare for the next pandemic, most of the world's people will not have access to affordable supplies of vaccines and antiviral agents. (wiley.com)
  • No disease modifying anti-osteoarthritic drug (DMOAD) has been approved. (duke.edu)
  • We thus studied the effect of anti-inflammatory drug administration in TGF-beta1-induced pathology. (inserm.fr)
  • This grant will allow us to explore the incorporation of these potent anti-inflammatory agents into drug-eluting stents. (freethesaurus.com)
  • The first patent relates to a new generation of anti-inflammatory agents which show improved pharmacokinetic and drug delivery characteristics but which work in the same way as the currently patented agents. (freethesaurus.com)
  • Inflammatory cells play important roles in tumor progression. (mdpi.com)
  • Further basic studies examining the relationship between the inflammatory process and prostate cancer progression are warranted. (mdpi.com)