Anti inflammatory agents. Medical search

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

A specific inhibitor of phosphoserine/threonine protein phosphatase 1 and 2a. It is also a potent tumor promoter. (Thromb Res 1992;67(4):345-54 & Cancer Res 1993;53(2):239-41)

Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)

A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.

Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.

The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).

A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.

A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.

A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.

The characteristic three-dimensional shape of a molecule.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.

A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.

Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.

A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).

A nucleoside consisting of the base guanine and the sugar deoxyribose.

Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

Cytosine nucleotides which contain deoxyribose as the sugar moiety.

A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)

Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.

Adenine nucleotides which contain deoxyribose as the sugar moiety.

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.

An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.

The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.

The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.

Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Use of plants or herbs to treat diseases or to alleviate pain.

The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.

Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)

Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.

Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)

The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.

Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)

The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)

Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.

A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.

A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.

A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.

Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)

The structure of one molecule that imitates or simulates the structure of a different molecule.

Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.

INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

The rate dynamics in chemical or physical systems.

Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.

A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)

Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.

INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.

The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)

The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.

A cell line derived from cultured tumor cells.

A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.

A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.

Immunoglobulins produced in a response to BACTERIAL ANTIGENS.

Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.

The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.

Elements of limited time intervals, contributing to particular results or situations.

The processes triggered by interactions of ANTIBODIES with their ANTIGENS.

Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)

DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.

Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

An encapsulated lymphatic organ through which venous blood filters.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.

The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.

Proteins prepared by recombinant DNA technology.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).

A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment. (1/7049)

AIM: To examine the effect of corticosteroid treatment on the expression of inducible nitric oxide synthase (iNOS) in the colon of patients with inflammatory bowel disease. METHODS: Four groups of patients were studied: (1) ulcerative colitis treated with high dose corticosteroids (six patients, 10 blocks); (2) ulcerative colitis patients who had never received corticosteroids (10 patients, 16 blocks); (3) Crohn's disease treated with high dose corticosteroids (12 patients, 24 blocks); (4) Non-inflammatory, non-neoplastic controls (four patients, six blocks). Full thickness paraffin sections of colons removed at surgery were immunostained with an antibody raised against the C terminal end of iNOS. Sections were assessed semiquantitatively for the presence and degree of inflammation and immunoreactivity for nitric oxide synthase. RESULTS: Cases of ulcerative colitis and Crohn's disease with active inflammation showed strong staining for nitric oxide synthase. The staining was diffuse in ulcerative colitis and patchy in Crohn's disease, in accordance with the distribution of active inflammation. Staining was seen in epithelial cells and was most intense near areas of inflammation such as crypt abscesses. Non-inflamed epithelium showed no immunoreactivity. Treatment with corticosteroids made no difference to the amount of nitric oxide synthase. CONCLUSIONS: Expression of nitric oxide synthase is increased in both ulcerative colitis and Crohn's disease and appears to be unaffected by treatment with corticosteroids. Disease severity necessitated surgery in all the cases included in this study, regardless of whether or not the patients had received long term corticosteroid treatment. It seems therefore that a high level of iNOS expression and, presumably, production of nitric oxide characterise cases which are refractory to clinical treatment; this suggests that specific inhibition of the enzyme may be a useful therapeutic adjunct. (+info)

Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids. (2/7049)

Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids. (+info)

Pharmacological studies on root bark of mulberry tree (Morus alba L.) (3/7049)

Pharmacological studies were done on the root bark of mulberry tree and pharmacological effects were compared with the clinical effects of "Sohakuhi" in Chinese medicine. n-Butanol- and water-soluble fractions of mulberry root had similar effects except for those on the cadiovascular system. Both fractions showed cathartic, analgesic, diuretic, antitussive, antiedema, sedative, anticonvulsant, and hypotensive actions in mice, rats, guinea pigs and dogs. There appears to be a correlation between the experimental pharmacological results and the clinical applications of mulberry root found in the literature on Chinese medicine. (+info)

Analysis of Chinese herbal creams prescribed for dermatological conditions. (4/7049)

OBJECTIVE: To determine whether Chinese herbal creams used for the treatment of dermatological conditions contain steroids. DESIGN: 11 herbal creams obtained from patients attending general and paediatric dermatology outpatient clinics were analysed with high resolution gas chromatography and mass spectrometry. SETTING: Departments of dermatology and clinical biochemistry. MAIN OUTCOME MEASURE: Presence of steroid. RESULTS: Eight creams contained dexamethasone at a mean concentration of 456 micrograms/g (range 64 to 1500 micrograms/g). All were applied to areas of sensitive skin such as face and flexures. CONCLUSION: Greater regulation needs to be imposed on Chinese herbalists to prevent illegal and inappropriate prescribing of potent steroids. (+info)

Characteristics of spontaneous erythema appeared in hairless rats. (5/7049)

The hairless rat (WBN/Kob-Ht), a dominant mutant rat derived from the Wistar strain, rarely develops spontaneous erythema of a progressive nature on its skin. Erythema was first observed at 8 weeks of age and the incidence at 20 weeks of age was about 4% in both males and females. Histopathologically, erythema was characterised by dermatitis induced by an immunological reaction. Areas of erythema in the skin were decreased by treatment with dexamethasone (1 mg/kg) or ciclosporin (25 or 50 mg/kg). These results suggested that erythema on the hairless rat could be used as an animal model of spontaneous dermatitis. (+info)

Topical psoriasis therapy. (6/7049)

Psoriasis is a common dermatosis, affecting from 1 to 3 percent of the population. Until recently, the mainstays of topical therapy have been corticosteroids, tars, anthralins and keratolytics. Recently, however, vitamin D analogs, a new anthralin preparation and topical retinoids have expanded physicians' therapeutic armamentarium. These new topical therapies offer increased hope and convenience to the large patient population with psoriasis. (+info)

Altered leucocyte trafficking and suppressed tumour necrosis factor alpha release from peripheral blood monocytes after intra-articular glucocorticoid treatment. (7/7049)

OBJECTIVES: A generalised transient improvement may follow intra-articular administration of glucocorticoids to patients with inflammatory arthropathy. This may represent a systemic anti-inflammatory effect of glucocorticoid released from the joint, mediated through processes such as altered leucocyte trafficking or suppressed release of pro-inflammatory cytokines. Patients, who had received intra-articular injections of glucocorticoids were therefore studied for evidence of these two systemic effects. METHODS: Patients with rheumatoid arthritis were studied. Peripheral blood leucocyte counts, tumour necrosis factor alpha (TNF alpha) release by peripheral blood monocytes, blood cortisol concentrations, and blood methylprednisolone concentration were measured for 96 hours after intra-articular injection of methylprednisolone acetate. RESULTS: Measurable concentrations of methylprednisolone were present in blood for up to 96 hours after injection. Significant suppression of the hypothalamic-pituitary-adrenal axis persisted throughout this time. Altered monocyte and lymphocyte trafficking, as evidenced by peripheral blood monocytopenia and lymphopenia, was apparent by four hours after injection and resolved in concordance with the elimination of methylprednisolone. Granulocytosis was observed at 24 and 48 hours. Release of TNF alpha by endotoxin stimulated peripheral blood monocytes was suppressed at four hours and thereafter. Suppression was maximal at eight hours and was largely reversed by the glucocorticoid antagonist, mifepristone. CONCLUSIONS: After intra-articular injection of methylprednisolone, blood concentrations of glucocorticoid are sufficient to suppress monocyte TNF alpha release for at least four days and to transiently alter leucocyte trafficking. These effects help to explain the transient systemic response to intra-articular glucocorticoids. Suppression of TNF alpha is principally a direct glucocorticoid effect, rather than a consequence of other methylprednisolone induced changes to blood composition. (+info)

A comparative study of the effects of ketotifen, disodium cromoglycate, and beclomethasone dipropionate on bronchial mucosa and asthma symptoms in patients with atopic asthma. (8/7049)

Asthma is a chronic inflammatory disorder of the airways that is characterized by infiltration of many inflammatory cells into the bronchial mucosa. We compared the effects of ketotifen, disodium cromoglycate (DSCG), and beclomethasone dipropionate (BDP) on inflammatory cells in the bronchial mucosa and on the asthma symptoms of patients with atopic asthma. In this 12-week parallel study, 32 patients were randomly allocated to either the ketotifen group (2 mg day-1, n = 13), DSCG group (8 mg day-1, n = 9) or BDP (400 micrograms day-1, n = 10). Each subject recorded daily asthma symptoms and peak expiratory flow (PEF). Before and after treatment, pulmonary function and bronchial responsiveness to methacholine were evaluated, and fibreoptic bronchoscopy and biopsy were performed before and after treatment. Biopsy specimens were obtained by bronchoscopy. We performed immunohistochemistry using specific monoclonal antibodies for activated eosinophils (EG2), mast cells (AA1), and T cells (CD3, CD4, and CD8). Our clinical findings showed significant improvement in symptom score and bronchial responsiveness (P < 0.01) each) in all groups. Both the DSCG and the BDP groups had significantly better symptom scores than the ketotifen group (P < 0.05, both groups). PEF significantly increased in the DSCG group in comparison to the ketotifen (P < 0.01) and BDP (P < 0.05) groups, FEV1% increased significantly in the DSCG (P < 0.01) and BDP (P < 0.05) groups in comparison to the ketotifen group. Compared with their baseline values, treatment significantly decreased EG2+ activated eosinophils, and CD3+ and CD4+ T cells, in each group (P < 0.01). Both the DSCG (P < 0.05) and the BDP groups (P < 0.01) exhibited significant decreases in AA1+ mast cell count, but this was not observed in the ketotifen group. Comparing before- and after-treatment values, only the DSCG group exhibited a significant decrease in the number of CD8+ T cells (P < 0.01). Ketotifen, DSCG, and BDP all showed anti-inflammatory activity as determined by examination of the bronchial mucosa of asthmatic patients; and both the DSCG and BDP groups had better clinical responses than the ketotifen group. (+info)

The anti-inflammatory components in breast milk are those bioactive substances that confer or increase the anti-inflammatory ...

https://en.wikipedia.org/wiki/Anti_inflammatory_agents_in_breast_milk

2001 an-Mar;124(1-3):201-4. (Anti-inflammatory agents). ... Immune Selective Anti-Inflammatory Derivatives (ImSAIDs) are a ... The ImSAIDs represent a new category of anti-inflammatory and are unrelated to steroid hormones or non steroidal anti- ... class of peptides that have anti-inflammatory properties. ImSAIDs work by altering the activation and migration of inflammatory ... One SGP-T derivative is a three amino acid sequence shown to be a potent anti-inflammatory molecule with systemic effects. This ...

https://en.wikipedia.org/wiki/Immune-selective_anti-inflammatory_derivative

NSAIDs are used as anti- inflammatory, antipyretic and analgesic agents. They can be administered through different routes, ... "Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system". Prostaglandins & Other Lipid Mediators ... Glucocorticoids are potent anti- inflammatory drugs. They are mainly administered via oral and pulmonary route. Oral ... Kim, Soo Young; Chang, Yoon-Jung; Cho, Hye Min; Hwang, Ye-Won; Moon, Yoo Sun (2015-09-21). "Non-steroidal anti-inflammatory ...

https://en.wikipedia.org/wiki/Prostaglandin_inhibitors

Prostaglandins, Anti-inflammatory agents). ... Studies indicated the anti-inflammatory actions of the ... Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG (2000). "Anti-inflammatory cyclopentenone prostaglandins ... Kim WJ, Kim JH, Jang SK (2007). "Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A ... and the two epoxyisoprostanes are suggested to be models for the development of novel anti-inflammatory and anti-cancer drugs. ...

https://en.wikipedia.org/wiki/Cyclopentenone_prostaglandins

Cullen E (May 1984). "Novel anti-inflammatory agents". Journal of Pharmaceutical Sciences. 73 (5): 579-89. doi:10.1002/jps. ... Nonsteroidal anti-inflammatory drugs, COX-2 inhibitors, Triazines, Phenol ethers, All stub articles, Musculoskeletal system ...

https://en.wikipedia.org/wiki/Anitrazafen

ATC codes, Anti-inflammatory agents). ... ATC code M01 Anti-inflammatory and antirheumatic products is a ...

https://en.wikipedia.org/wiki/ATC_code_M01

9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3. Austin RJ, Maschera B, Walker A, ... It is believed that the action of corticosteroid anti-inflammatory agents is bound to inhibitive proteins of phospholipase A2, ... Reversing the activation of inflammatory proteins Activating the secretion of anti-inflammatory proteins Stabilizing cell ... Mometasone furoate can be used with formoterol for the treatment of asthma, due to its anti-inflammatory properties. People ...

https://en.wikipedia.org/wiki/Mometasone

Trichostatin A (TSA) and others are being investigated as anti-inflammatory agents. After the successful initial round of in ... Adcock IM (April 2007). "HDAC inhibitors as anti-inflammatory agents". British Journal of Pharmacology. 150 (7): 829-31. doi: ... HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. The prime example of this ... HDIs have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptics. More recently they are ...

https://en.wikipedia.org/wiki/Histone_deacetylase_inhibitor

"HDAC inhibitors as anti-inflammatory agents". Br. J. Pharmacol. 150 (7): 829-31. doi:10.1038/sj.bjp.0707166. PMC 2013887. PMID ... Thus, TSA has some potential as an anti-cancer drug. One suggested mechanism is that TSA promotes the expression of apoptosis- ... HDIs have multiple effects on non-histone effector molecules, so the anti-cancer mechanisms are truly not understood at this ... "Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view". Curr Med ...

https://en.wikipedia.org/wiki/Trichostatin_A

Stewart, William K.; Fleming, L. W. (1 October 1987). "Perthshire Pioneer of Anti-Inflammatory Agents". Scottish Medical ... He carried out research into the effect of salicin, an extract from willow bark and a known anti-rheumatic treatment. This work ... pharmacologist from Perthshire who pioneered the clinical use of thermometers and the use of salicin as an anti-inflammatory ...

https://en.wikipedia.org/wiki/Thomas_John_MacLagan

Hepcidin itself is also an anti-inflammatory agent. In the murine model very low levels of iron restrict hepcidin synthesis, ... Treatment is usually started by administering drugs with high anti-inflammatory effects, such as prednisone. Once the ... Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine, Crohn's disease and ... Inflammatory bowel disease-22 World Inflammatory Bowel Disease Day GBD 2015 Disease and Injury Incidence and Prevalence ...

https://en.wikipedia.org/wiki/Inflammatory_bowel_disease

"Plant phenylpropanoids as emerging anti-inflammatory agents". Mini Reviews in Medicinal Chemistry. 11 (10): 823-35. doi:10.2174 ... inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose- ...

https://en.wikipedia.org/wiki/Lignan

... is an antiinflammatory agent. More specifically, it is a nonsteroidal anti-inflammatory drug (NSAID) that acts via ... a new nonsteroidal anti-inflammatory agent". Journal of Pharmaceutical Sciences. 64 (9): 1469-75. doi:10.1002/jps.2600640909. ... Nonsteroidal anti-inflammatory drugs, Imidazoles, Trifluoromethyl compounds, Phenol ethers, All stub articles, Musculoskeletal ...

https://en.wikipedia.org/wiki/Flumizole

"แกงหมูกระท้อน". แกงคั่วกระท้อนกุ้ง Rasadah, M.A.; Khozirah, S.; Aznie, A.A.; Nik, M.M. (2004). "Anti-inflammatory agents from ... Several parts of the plant may have anti-inflammatory effects, and some chemical extracts from santol stems have shown anti- ... The partly ripe sour fruits are also used as a souring agent in sour broth dishes like sinigang. In Thai cuisine this fruit is ... "Plant anticancer agents, L. Cytotoxic triterpenes from Sandoricum koetjape stems

https://en.wikipedia.org/wiki/Sandoricum_koetjape

Among them are serotonin, a neurotransmitter; indometacin, a non-steroidal anti-inflammatory agent; L-761,066, a COX-2 ...

https://en.wikipedia.org/wiki/Nenitzescu_indole_synthesis

Olkkola KT, Brunetto AV, Mattila MJ (February 1994). "Pharmacokinetics of oxicam nonsteroidal anti-inflammatory agents". ... Oxicam is a class of non-steroidal anti-inflammatory drugs (NSAIDs), meaning that they have anti-inflammatory, analgesic, and ... Nonsteroidal anti-inflammatory drugs, Sultams, All stub articles, Musculoskeletal system drug stubs). ...

https://en.wikipedia.org/wiki/Oxicam

It is anti-inflammatory agent as well. GW501516 Elafibranor Peroxisome proliferator-activated receptor "Cayman Chemical GW0742 ... vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity". Journal of Hypertension. 33 ( ...

https://en.wikipedia.org/wiki/GW0742

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 11 (3): 230-237. doi:10.2174/1871523011202030230. PMID 23173575 ... 11 July 2018). Frontiers in Clinical Drug Research - Anti-Allergy Agents, Volume 3. Bentham Science Publishers. pp. 30-. ISBN ... As of 2004, doxylamine and diphenhydramine, which are both over-the-counter medications, were the agents most commonly used to ... Culpepper L, Wingertzahn MA (2015). "Over-the-Counter Agents for the Treatment of Occasional Disturbed Sleep or Transient ...

https://en.wikipedia.org/wiki/Doxylamine

... is used as an anti-inflammatory agent for both acute and long-term inflammation, as well as for treatment of ... Aspirin, along with several other agents with anti-inflammatory properties, has been repurposed as an add-on treatment for ... Thus, notwithstanding the biological rationale, the clinical perspectives of aspirin and anti-inflammatory agents in the ... Thus, notwithstanding the biological rationale, the clinical perspectives of aspirin and anti-inflammatory agents in the ...

https://en.wikipedia.org/wiki/Aspirin

The herbage contains antibacterial and anti-inflammatory agents.[citation needed] The leaves of this plant are natural insect ... It is used as a massage oil and an agent of aromatherapy. It may also be diluted, placed in the palms of the hands, and inhaled ...

https://en.wikipedia.org/wiki/Salvia_stenophylla

Sullivan GW (November 2003). "Adenosine A2A receptor agonists as anti-inflammatory agents". Current Opinion in Investigational ... Flow cytometry studies with anti-A2A receptor monoclonal antibodies". Molecular Pharmacology. 55 (3): 614-24. PMID 10051547. ...

https://en.wikipedia.org/wiki/Adenosine_A2A_receptor

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 12 (3): 223-8. doi:10.2174/1871523011312030003. PMID 23651231. ...

https://en.wikipedia.org/wiki/Nail_biting

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 5 (2): 139-146. doi:10.2174/187152306776872442. Grünfeld, JP; ... Newer agents such as anti Vascular Endothelial Growth Factor (anti VEGF) are also associated with similar injuries, as well as ... The pain medicines which can cause kidney problems include aspirin, acetaminophen, and nonsteroidal anti-inflammatory drugs ( ... Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation ...

https://en.wikipedia.org/wiki/Kidney_disease

"Role of RCP006 as an anti-inflammatory agent". Roskamp Institute. Archived from the original on 2011-10-23. Retrieved 2011-09- ... Many natural products (including anti-oxidants) that have been promoted to have anti-cancer and anti-inflammatory activity have ... resulting in reduced levels of the anti-inflammatory, pro-autophagy, anti-insulin resistance protein sirtuin 1. NF-κB increases ... Vidal PM, Lemmens E, Dooley D, Hendrix S (February 2013). "The role of "anti-inflammatory" cytokines in axon regeneration". ...

https://en.wikipedia.org/wiki/NF-κB

Antigout agents, Carboxamides, Chloroarenes, Hepatotoxins, Indole ethers at the benzene ring, Nonsteroidal anti-inflammatory ... A New Non-steroid Anti-inflammatory Agent". British Medical Journal. 2 (5363): 965-70. doi:10.1136/bmj.2.5363.965. PMC 1873102 ... Indometacin, a non-steroidal anti-inflammatory drug (NSAID), has similar mode of action when compared to other drugs in this ... Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription ...

https://en.wikipedia.org/wiki/Indometacin

Hart, F. Dudley; Boardman, P. L. (19 October 1963). "Indomethacin: A New Non-steroid Anti-inflammatory Agent". BMJ. 2 (5363): ... Under the auspices of the Royal College of Physicians, he delivered in 1975 the Bradshaw Lecture on Inflammatory disease and ...

https://en.wikipedia.org/wiki/Francis_Dudley_Hart

Anti-Inflammatory & Anti-Allergy Agents. 3 (3): 207-216. doi:10.2174/1568014043355348. James NT, Meek GA (January 1976). " ... Studies involving carbon monoxide have been conducted in many laboratories throughout the world for its anti-inflammatory and ... "CO as a therapeutic agent: discovery and delivery forms". Chinese Journal of Natural Medicines. 18 (4): 284-295. doi:10.1016/ ...

https://en.wikipedia.org/wiki/Gasotransmitter

Kontogiorgis CA, Hadjipavlou-Litina DJ (January 2002). "Non steroidal anti-inflammatory and anti-allergy agents". Current ... The anti-IL-20 antibody has been shown to reduce the severity of RA in rats, mitigate bone destruction, and more. The anti-IL- ... Due to the clear association of IL-20 with RA, anti-IL-20 antibody is now in a clinical trial for RA. Anti-IL-20 monoclonal ... Hsu YH, Chen WY, Chan CH, Wu CH, Sun ZJ, Chang MS (August 2011). "Anti-IL-20 monoclonal antibody inhibits the differentiation ...

https://en.wikipedia.org/wiki/Interleukin_20

Anti-Inflammatory & Anti-Allergy Agents. 3 (3): 207-216. doi:10.2174/1568014043355348. Yoon, Y.; Song, U.; Hong, S.H.; Kim, J.Q ... Navin, K.T.; Toshio, H.A.; Daigo, S.I.; Hatsuyo, K.; Hisako, M.; Taku, T.S.; Akihisa, A. (2002). "Anti-Atherosclerotic Effect ... A rise in salivary levels is indicative of diets rich in leafy vegetables which are often abundant in anti-hypertensive diets ... mediators to dampen and reverse inflammatory responses by neutralizing and then speeding the clearance of pro-inflammatory ...

https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide

3296-. ISBN 978-0-8155-1856-3. Scherrer R (2 December 2012). Anti-inflammatory Agents Part I: Chemistry and Pharmacology. ...

https://en.wikipedia.org/wiki/Tralonide

The lipoxins and epi-lipoxins are potent anti-inflammatory agents and may contribute to the overall activities of the two COX's ... Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin production by PTGS1 (COX-1) and PTGS2 (COX-2). NSAIDs ... Tikhonovich, Marina V.; Erdiakov, Aleksei K.; Gavrilova, Svetlana A. (2017-06-21). "Nonsteroid anti-inflammatory therapy ... PTGS2 is linked with the inflammatory system and has been observed in inflammatory leukocytes. It has been noted that there is ...

https://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase_2

The anti-proprietary party dispatched him to England again to continue the struggle against the Penn family proprietorship. ... Franklin became a national hero in America as an agent for several colonies when he spearheaded an effort in London to have the ... and churned out effective and inflammatory propaganda." By the time Franklin arrived in Philadelphia on May 5, 1775, after his ... One early proponent that Franklin was a member of the Hellfire Club and a double agent is the historian Donald McCormick, who ...

https://en.wikipedia.org/wiki/Benjamin_Franklin

The FBI agent conducting the background check examination then called the wrong agency while making the inquiry into the drug ... It views women as trophies which are to be traded among men." Jamelle Bouie wrote in Slate, "Make any list of anti-black ... He left the church, reportedly after making another "racially inflammatory statement" over the victims' bodies. The entire ... D]eadly acts of terrorism by virulent racists and anti-government extremists have been more common in the United States than ...

https://en.wikipedia.org/wiki/Charleston_church_shooting

Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 ( ... The H5N1 influenza virus, also known as bird flu, has resistance to interferon and other anti-viral cytokines that is ... which are important for initiating synthesis of many inflammatory proteins. RNA interference technology tools such as siRNA or ... In a typical scenario, a virus-infected cell will release interferons causing nearby cells to heighten their anti-viral ...

https://en.wikipedia.org/wiki/Interferon

E.scaber modulates inflammatory responses by inhibiting the production of TNFα and IL-1β. Elephantopus scaber contains ... Different parts of the plant are used in traditional medicine of India as an astringent agent, cardiac tonic, and diuretic, and ... dihydro-deoxy elephantopin and 8-hydroxyl naringenin are the most important bioactive compounds responsible for anti-bacterial ...

https://en.wikipedia.org/wiki/Elephantopus_scaber

Analgesics, such as nonsteroidal anti-inflammatory drugs, may be used relieve pain. Ischial bursitis may be treated with ... An x-ray (using injected contrast agent) may be used to identify the formation of calluses. Ischial bursitis is usually treated ...

https://en.wikipedia.org/wiki/Ischial_bursitis

He obtained his Ph.D. degree in the mid-1970s working on the crystal structure determinations and design of anti-inflammatory ... inhibitors of target enzymes and potent antagonists of target receptors for eventually leading to useful therapeutic agents. He ... of lactoferrin protein with COX-2-specific non-steroidal anti-inflammatory drugs (NSAIDs)". Archives of Biochemistry and ...

https://en.wikipedia.org/wiki/Tej_P._Singh

Angiotensin-converting enzyme (ACE) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) are also drugs associated ... Calcimimetic agents may be necessary, e.g. Cinacalcet.[citation needed] In mild cases of milk-alkali syndrome, full recovery is ... For mild cases of MAS, the only intervention needed is to withdraw the offending agent. By having the person stop taking any ... as well as how to reverse the syndrome by discontinuing the offending agent and seeking medical attention. ...

https://en.wikipedia.org/wiki/Milk-alkali_syndrome

Segal suggested an HIV therapy of anti-inflammatory aspirin or ultraviolet radiation of the patient's blood in order to reduce ... Vasili Mitrokhin and two former members of East Germany's secret police revealed that Segal was a Soviet disinformation agent ...

https://en.wikipedia.org/wiki/Jakob_Segal

He gave him a copy of his pamphlet My Political Awakening, which contained anti-Semitic, nationalist, anti-capitalist, and anti ... However, after an inflammatory speech he gave on 27 February, Hitler was barred from public speaking by the Bavarian ... In July 1919 he was appointed Verbindungsmann (intelligence agent) of an Aufklärungskommando (reconnaissance unit) of the ... Anti-Americanism, Anti-Slavic sentiment, Anti-black racism in Germany, Antisemitism in Germany, Antiziganism, Articles ...

https://en.wikipedia.org/wiki/Adolf_Hitler

One agent code-named Baker, who claimed to have been present, confirmed that a campaign of violence had been discussed, as did ... Whatever inflammatory rhetoric may have been used by Congress leaders, there is no evidence that they planned to match their ... Sir Arthur Benson was also put under pressure to act against African anti-Federal parties and declare a State of Emergency in ... Henry Chipembere and Kanyama Chiume led to demands within Congress for an escalation of anti-government protests and a more ...

https://en.wikipedia.org/wiki/Nyasaland_emergency_of_1959

Aaseth has studies the effects of disease-modifying agents including anti-TNF-alpha drugs and also selenium compounds. Some of ... Oxidative stress accompanied by a low-grade inflammatory response appears to aggravate cardiovascular morbidity. Rheumatic ... Protective measures include the therapeutic use of new iron chelating agents, which have been studied by Aaseth and co-workers ... Analyst, 123(1), 3-6. Aaseth J (1983). Recent advance in the therapy of metal poisonings with chelating agents. Human ...

https://en.wikipedia.org/wiki/Jan_Aaseth

... s have been investigated as possible anti-inflammatory agents and evaluated on their anti-cancer and anti-oxidant ... antinociceptive and anti-inflammatory effects of porphyrins". Bioorganic & Medicinal Chemistry. 23 (10): 2529-2537. doi:10.1016 ... June 2021). "Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity". Bioconjugate ...

https://en.wikipedia.org/wiki/Porphyrin

Pain associated with Lyme disease may be treated with nonsteroidal anti-inflammatory drugs (NSAIDs). Corticosteroid joint ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... "Anti-vaxxers stopped the last Lyme disease vaccine. The FDA has just fast-tracked a new one". Newsweek. 25 July 2017. Archived ... The host inflammatory response to the bacteria in the skin causes the characteristic circular EM lesion. Neutrophils, however, ...

https://en.wikipedia.org/wiki/Lyme_disease

... sodium hypochlorite is used to remove all traces of nerve agent or blister agent from Personal Protection Equipment after an ... Sodium hypochlorite in solution exhibits broad spectrum anti-microbial activity and is widely used in healthcare facilities in ... Conger K (15 November 2013). "Inflammatory skin damage in mice blocked by bleach solution, study finds". Stanford School of ... 50% sodium hypochlorite is also used to neutralize any accidental releases of the nerve agent in the toxic areas. Lesser ...

https://en.wikipedia.org/wiki/Sodium_hypochlorite

In May 2017, Stephen Sedley said: "Anti-Semitism, where it manifests itself in discriminatory acts or inflammatory speech, is ... It turns out they were an agent in the Israeli Embassy", referring to The Lobby. In June 2019, Labour peer Peter Hain and ... I expect nothing less from an anti-racist party and an anti-racist leader." He continued, "There are many threats to Jews - and ... Finlay, Joseph (26 March 2018). "Jeremy Corbyn is an anti-racist, not an anti-Semite". The Times of Israel. Retrieved 1 March ...

https://en.wikipedia.org/wiki/Antisemitism_in_the_UK_Labour_Party

No agents from this class have successfully completed human clinical trials due to their unacceptable side effect profiles. ... Lynch JJ, Wade CL, Mikusa JP, Decker MW, Honore P (February 2005). "ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia ... epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain". Pain. 86 (1-2): 113-8. doi:10.1016/s0304- ... May 1998). "ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via ...

https://en.wikipedia.org/wiki/Tebanicline

The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression ... Stancato LF, Silverstein AM, Gitler C, Groner B, Pratt WB (April 1996). "Use of the thiol-specific derivatizing agent N- ... Coutinho AE, Chapman KE (March 2011). "The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent ... Kino T, Chrousos GP (June 2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS- ...

https://en.wikipedia.org/wiki/Glucocorticoid_receptor

Muscarinic antagonists (anti-cholinergics): Blocking the muscarinic acetylcholine receptors in pulmonary smooth muscle tissue ... While a different cause, this has very similar symptoms, namely the immunological reaction involving release of inflammatory ... for people with emphysema and there are several anticholinergic medications that in combination with mucous thinning agents ... During an episode of this type of bronchoconstriction, the levels of inflammatory mediators, particularly leukotrienes, ...

https://en.wikipedia.org/wiki/Bronchoconstriction

... protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects". J Neurochem. 113 (6): 1659-1675. ... Herraiz, T; Guillén, H (2011). "Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and ... a new anti-Parkinson drug?". Expert Rev Neurother. 11 (6): 845-860. doi:10.1586/ern.11.1. PMID 21651332. S2CID 24899640. ... and reduced expression of inflammatory cytokines. In studies of primary mesencephalic dopaminergic neuron cell cultures, the ...

https://en.wikipedia.org/wiki/9-Methyl-β-carboline

Since anti-pathogen inhibitors generally target only one enzyme, such drugs are highly specific and generally produce few side ... Zhang L, He J, Bai L, Ruan S, Yang T, Luo Y (July 2021). "Ribosome-targeting antibacterial agents: Advances, challenges, and ... Inhibitors of Janus kinases block the production of inflammatory cytokines and hence these inhibitors are used to treat a ... Dalhoff A (February 2021). "Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore ...

https://en.wikipedia.org/wiki/Enzyme_inhibitor

... for having subscribed to an anti-"White" petition. With support from the anti-Austrian Englishman Stephen "Mazar Pașa" Lakeman ... Distanced from the group, and acting as Romanian diplomatic agent in Pest, Radu Ionescu censured such projects: "People of ... Babeș denounced Românul for having published inflammatory articles against him, claiming that their pseudonymous author, ... The anti-Rosettist joke is again taken up in Caragiale's other main comedy, O scrisoare pierdută, with the matured National ...

https://en.wikipedia.org/wiki/Românul

If scarring is the main reason, anti-fibrotic and anti-inflammatory therapy has to be intensified in the second procedure. ... If 5-FU was used during surgery or if no anti-fibrotic agent was applied, 5 mg 5-FU daily can be injected in the 7-14 ... Topical medications consist typically of antibiotic drops four times per day and anti-inflammatory therapy e.g. with ...

https://en.wikipedia.org/wiki/Trabeculectomy

This was shown when the anti-hyperalgesic action was reduced when administered in α2 and α3 mice in inflammatory pain and in ... Sedative actions of benzodiazepines limit their usefulness as analgesic agents and they are therefore generally not considered ... Additionally, studies in α5 mice showed that the spinal α5-containing GABAA receptor has a minor role in inflammatory pain. An ... Although barbiturates fell out of favor, they continue to serve as a short-acting anesthetic and anti-epileptic drugs. ...

https://en.wikipedia.org/wiki/GABAA_receptor_positive_allosteric_modulator

Meclofenamate sodium (MS) is known for its anti-inflammatory activity, and apart from this, Boctor et al. [37] reported that it ... For patients with metastatic prostate cancer that has spread to their bones, doctors use a variety of bone-modifying agents to ... "A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence". Journal of the ... The Times also noted an "anti-male bias in cancer funding" with a four-to-one discrepancy in the United Kingdom by both the ...

https://en.wikipedia.org/wiki/Prostate_cancer

Butyrate also possesses anti-inflammatory effects to decrease colonic inflammation such as ulcerative colitis. One study ... it is hypothesized that butyrate can act as a protective agent against colon cancer and various inflammatory bowel diseases. ... "Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease". Gut. 47 (3): 397-403. ... specifically identified the transcription factor NF-kB as a target of butyrate to decrease the number of pro-inflammatory ...

https://en.wikipedia.org/wiki/Butyrate_kinase

Moore RA, Chi CC, Wiffen PJ, Derry S, Rice AS (October 2015). "Oral nonsteroidal anti-inflammatory drugs for neuropathic pain ... Note NO mention of MS "Service-Connected Disability Compensation For Exposure To Agent Orange" (PDF). Vietnam Veterans of ... Few studies have examined whether nonsteroidal anti-inflammatory drugs are effective in treating peripheral neuropathy. There ... as in some inflammatory neuropathies, such as Guillain-Barré syndrome; or may show focal sensory disturbance or weakness, such ...

https://en.wikipedia.org/wiki/Peripheral_neuropathy

The production of anti-inflammatory proteins, and the degeneration of mRNA encoding inflammatory proteins, can also be ... Possible causative agents include radiation therapy of the chest, exposure to medications used during chemo-therapy, the ... Some degree of pulmonary fibrosis may be evident in a CT which is indicative of chronic pulmonary inflammatory processes. ... These all share similar symptoms, but differ in causative agents. Diagnosis of pneumonitis remains challenging, but several ...

https://en.wikipedia.org/wiki/Pneumonitis

Topical anti-inflammatory agents. Class Summary. This industrial solvent has been used with mixed results. ... These agents act by competitive inhibition of histamine at the H1 receptor. They may control itching by blocking effects of ...

https://www.medscape.com/answers/1102860-174627/which-medications-in-the-drug-class-topical-anti-inflammatory-agents-are-used-in-the-treatment-of-macular-amyloidosis

Anti-inflammatory agents. Class Summary. IgA pemphigus is characterized histologically by inflammatory cell (neutrophil) ... Anti-inflammatory agents theoretically block the inflammatory process and improve the disease conditions. [41, 43] ... Anti-inflammatory agents theoretically block the inflammatory process and improve the disease conditions. ... Dapsone is used alone or in conjunction with other anti-inflammatory medications for treating IgA pemphigus. Consult a ...

https://emedicine.medscape.com/article/1063776-medication

1517 Studies found for: PREDNISOLONE AND Pred Forte AND Anti-Inflammatory Agents ...

https://www.clinicaltrials.gov/ct2/results/browse?term=PREDNISOLONE+AND+Pred+Forte+AND+Anti-Inflammatory+Agents&brwse=cond_alpha_all

Concern over the scale of morbidity associated with the use of oral non-steroidal anti-inflammatory drugs (NSAIDs), ... Anti-Inflammatory Agents, Non-Steroidal / administration & dosage* * Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics ... Transdermal non-steroidal anti-inflammatory agents Br J Clin Pract. 1995 Jan-Feb;49(1):33-5. ... Concern over the scale of morbidity associated with the use of oral non-steroidal anti-inflammatory drugs (NSAIDs), ...

https://pubmed.ncbi.nlm.nih.gov/7742182/?dopt=Abstract

Purchase Anti-inflammatory Agents Part I - 1st Edition. Print Book & E-Book. ISBN 9780126239010, 9780323150156 ... Receptor Site for Classical Antiinflammatory Agents. VI. Latent Antiinflammatory Agents. VII. Two Nonclassical Antiinflammatory ... Part II explores the nonsteroidal anti-inflammatory agents that are peripheral analgesics and anti-pyretic. Other chapters ... Anti-inflammatory Agents Part I. Holiday Sale. :. Save up to 25% on print and eBooks with FREE shipping. No promo code needed. ...

https://www.elsevier.com/books/anti-inflammatory-agents-part-i/scherrer/978-0-12-623901-0

Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti- ... This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological ... Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular ... multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory ...

https://www.hindawi.com/journals/ije/2017/1835195/

2 Abstracts with Anti-Inflammatory Agents: Non-Steroidal Research. Filter by Study Type. Animal Study. ... Pharmacological Actions : Analgesics, Anti-Inflammatory Agents: Non-Steroidal. Additional Keywords : Natural Substances Versus ... 2 Substances Researched for Anti-Inflammatory Agents: Non-Steroidal Name. AC. CK. Focus. ... Researchers have declared that tart cherries have the "highest anti-inflammatory content of any food." They can help you manage ...

https://greenmedinfo.com/pharmacological-action/anti-inflammatory-agents-non-steroidal

... anti-inflammatory.html. Embed article link: (copy HTML code below):. Systemic enzymes work as anti-inflammatory agents. ... anti-inflammatory medication is prescribed by doctors all over the world, but the best natural anti-inflammatory agents are ... Systemic enzymes work as anti-inflammatory agents. Wednesday, July 20, 2011 by: Alex Malinsky aka RawGuru. Tags: enzymes, anti- ... For people that are in need of a safe anti-inflammatory, systemic enzymes are the wonderful method of treatment.. Sources. http ...

https://www.naturalnews.com/033051_enzymes_anti-inflammatory.html

... are structurally similar and have anti-inflammatory functions that resemble those of nonsteroidal anti-inflammatory agents. ... Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections. Ehrenpreis, Eli D. MD; Kruchko, David H. DO ... ibuprofen\r, nonsteroidal anti-inflammatory agents\r, aminosalicylates\r, COVID-19\r, irritable bowel disease. ... Rapid Review: Nonsteroidal Anti-inflammatory Agents and Aminosalicylates in COVID-19 Infections : Journal of Clinical ...

https://journals.lww.com/jcge/Abstract/2020/08000/Rapid_Review__Nonsteroidal_Anti_inflammatory.5.aspx

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Class Summary. These agents have analgesic, anti-inflammatory, and antipyretic ... Antianxiety Agents. Class Summary. These agents are indicated for patients who may experience significant anxiety before a ... It inhibits inflammatory reactions and pain by decreasing the activity of the enzyme COX, which results in prostaglandin ... It is commonly used in combination with an agent against gram-positive organisms and one that covers anaerobes. The drug is ...

https://emedicine.medscape.com/article/189563-medication

Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms ... Anti-inflammatory agents can effectively and safely curb major depressive symptoms. October 28, 2019. Anti-inflammatory agents ... Anti-inflammatory agents included: non-steroidal anti-inflammatory drugs (NSAIDs); omega 3 fatty acids; drugs that curb ... But anti inflammatory agents didnt seem to improve quality of life, although this might have been because of the small number ...

https://www.brightsurf.com/news/article/102819495527/anti-inflammatory-agents-can-effectively-and-safely-curb-major-depressive-symptoms.html

Guidelines for Using Anti-Inflammatory Agents in the Management of Asthma. Feb 7, 2007 , Asthma , ... Alternative agents for anti-inflammatory treatment of asthma. J Allergy Clin Immunol. 1998;102:S23-S35.. 7. Szefler SJ. Risks ... Corticosteroids are considered to be the most potent and effective anti-inflammatory agents currently available.8 ... Daily anti-inflammatory medications:. High-dose inhaled corticosteroid with spacer and face mask, AND. Oral steroids to be ...

https://rtmagazine.com/disorders-diseases/chronic-pulmonary-disorders/asthma/guidelines-for-using-anti-inflammatory-agents-in-the-management-of-asthma/

Crystal structure of the complex formed between groupII phospholipase A2 and anti-inflammatory agent 2-[(2,6-Dichlorophenyl) ... Crystal structure of the complex formed between group II phospholipase A2 and anti-inflammatory agent 2-[(2,6-Dichlorophenyl) ... Crystal structure of the complex formed between groupII phospholipase A2 and anti-inflammatory agent 2-[(2,6-Dichlorophenyl) ...

https://www.rcsb.org/structure/1SV9

... responsible for inhibition of pro-inflammatory enzymes. Out of these four boswellic acids, acetyl-11-keto-β-boswellic acid is ... Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview. Author(s): MZ Siddiqui. DOI: 10.4103/0250-474X.93507 ... Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract." Immunomodulatory ... extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory ...

https://www.ijpsonline.com/abstract/boswellia-serrata-a-potential-antiinflammatory-agent-an-overview-82.html

Ketorolac Tromethamine ophthalmic solutions and tablets are indicated for the temporary relief of ocular itching due to seasonal allergic conjunctivitis and for the treatment of postoperative inflammation in patients who have undergone cataract extraction.

https://www.accutome.com/ketorolac-drops-0-5-10ml

Effects of Some Nonsteroidal Anti-Inflammatory Agents on Experimental Radiation Pneumonitis Nicholas J. Gross; Nicholas J. ... Nicholas J. Gross, Nathaniel O. Holloway, K. Roy Narine; Effects of Some Nonsteroidal Anti-Inflammatory Agents on Experimental ... and that nonsteroidal anti-inflammatory agents, particularly those that affect lipoxygenase products, may offer equal or better ... We explored the possibility that this effect was due to their well-known anti-inflammatory actions by giving various ...

https://meridian.allenpress.com/radiation-research/article-abstract/127/3/317/39111/Effects-of-Some-Nonsteroidal-Anti-Inflammatory?redirectedFrom=fulltext

Srimal R. C., Dhawan B. N. Pharmacology of diferuloylmethane (curcumin), a non-steroidal anti-inflammatory agent. J. Pharm. ... Curcumin, a naturally occurring anti-inflammatory agent and antioxidant, has been shown to inhibit tumors in several organs, ... Our results also demonstrate for the first time that curcumin, a naturally occurring anti-inflammatory agent and antioxidant, ... Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of ...

https://aacrjournals.org/cancerres/article/59/3/597/505802/Chemopreventive-Effect-of-Curcumin-a-Naturally

... anti-inflammatory drugs Menu button for Aerosolized Agents - metered-dose inhalers: anti-inflammatory drugs"> * 1. Dosage ... Aerosolized Agents - metered-dose inhalers: anti-cholinergic drugs * Aerosolized Agents - metered-dose inhalers: ... Aerosolized Agents - metered-dose inhalers: beta2 adrenergic drugs (long-acting) * Aerosolized Agents - metered-dose inhalers: ...

https://www.txvendordrug.com/about/manuals/retrospective-drug-use-criteria-handbook/c-3-drug-use-criteria/aerosolized-agents-metered-dose-inhalers-anti-inflammatory-drugs

From: RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non- ...

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4641-x/tables/3

Anti-Inflammatory Agents) , Personal Care & Cosmetics formulations, data sheets, MSDS search, specifications and request ... It acts as a skin conditioning agent with soothing anti-inflammatory properties. This product appears as a white or pale ... It acts as a skin conditioning agent with soothing anti-inflammatory properties. This product appears as a white or pale ... Vitamin E Acetate is an excellent anti-oxidant and anti-inflammatory. It has good moisturization properties, and leaves skin ...

https://www.ulprospector.com/en/na/PersonalCare/Products/25679/Esters/Functionalities/2305/Anti-Inflammatory-Agents/Product

Our coverage of anti inflammatory agents news, knowledge and opinion is widely. ... anti inflammatory agents. Echemi shares information about anti inflammatory agents. Our coverage of anti inflammatory agents ... peptides anti aging fourth state anti inflammatory agents anti aging science anti static plastic ... anti inflammatory juice synthesis reaction example industrial chemical company all matter made anti inflammatory agents ...

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Trends and demographic patterns in biologic and corticosteroid prescriptions for inflammatory bowel disease: findings from ...

https://jim.bmj.com/keyword/anti-inflammatory-agents-non-steroidal

Nonsteroidal Anti-inflammatory Agents. Class Summary. These agents inhibit growth of adenomatous polyps and cause regression of ... and anti-inflammatory, are mostly mediated by inhibition of prostaglandin synthesis. This agent may be considered for off-label ... Sulindac is a sulfoxide, which is metabolized to the anti-inflammatory sulfide metabolite and a sulfone metabolite. Both ... This agent inhibits primarily COX-2. COX-2 has been found to be up-regulated in a variety of premalignant disorders and ...

https://emedicine.staging.medscape.com/article/1664300-medication

Topical anti-inflammatory agents. Class Summary. This agent is an industrial solvent. ... These agents act by competitive inhibition of histamine at the H1 receptor. They may control itching by blocking effects of ...

https://www.staging.medscape.com/answers/1102672-201399/what-is-role-of-medications-in-the-treatment-of-lichen-amyloidosis

Efficacy of medrysone as anti-inflammatory agent. Indian Journal of Ophthalmology. 1985 Sep-Oct; 33(5): 295-7. ...

https://imsear.searo.who.int/handle/123456789/71931

... Outras Variações. 1. Anti-inflammatory and anti- ... Anti-inflammatory and anti-allergy agents in medicinal chemistry (Online).-- (2006) -.-- ISSN 1875-614X. ...

http://portalrev.enfermagem.bvs.br/index.php?mfn=9715&about=access%E2%8C%A9=en

... Pasqualina Laganà. Writing - ... Objective: The aim of this article is to highlight antibacterial, antifungal, and anti-inflammatory activities of various ... Objective: The aim of this article is to highlight antibacterial, antifungal, and anti-inflammatory activities of various ... and anti-inflammatory, antibacterial, antiviral, and antifungal activities.. ...

https://www.iris.unict.it/handle/20.500.11769/483940

As these two research suggested, both δ- and γ-tocotrienols may be effective, long-term anti-inflammatory agents to reduce the ...

https://malaysia.healthtoday.net/natural-anti-inflammatory-agent/

Anti-Inflammatory Agents. Antiemetics. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. ... If anti-HBV therapy in relation with prior infection was started before initiation of IMP, the anti-HBV therapy and monitoring ... Patient can be eligible if anti-HBc IgG positive (with or without positive anti-HBs) but HBsAg and HBV DNA are negative. ... Immunogenicity: Incidence of anti-drug antibodies (ADA) [ Time Frame: Up to approximately 24 months ]. Number of participants ...

https://clinicaltrials.gov/show/NCT04270409

Publications Which contain the keyword: Anti-inflammatory agents. Synthesis and anti-inflammatory study of novel N-substituted ... 2018-10-18 13:25:27 Keywords Acridines; Bis-acridine;, Hexahydroacridinones;, Anti-inflammatory agents, ... 2018-10-05 14:10:22 Keywords Acridines, Bis-acridine, Hexahydroacridinones, Anti-inflammatory agents, ... Synthesis and Anti-inflammatory Study of Novel N-substituted Hydro-acridine-1,8-diones and Bis-hexahydroacridine-1,8-dione ...

https://staffsites.sohag-univ.edu.eg/stuff/home/tags/8063/1048

Concern over the scale of morbidity associated with the use of oral non-steroidal anti-inflammatory drugs (NSAIDs), particularly in the elderly, has led to the development of alternative strategies for the relief of musculoskeletal and joint pain. (nih.gov)
Ibuprofen phenylalanine derivatives 1-17 as new safe nonsteroidal anti-inflammatory drugs (NSAIDs) agents were synthesized and characterized depending on spectroscopic and analytical analyses. (ekb.eg)
In one study of 250 people with pain from degenerative disc disease, 59% of the participants were able to substitute fish oil for nonsteroidal anti-inflammatory drugs ( NSAIDs ). (medicalnewstoday.com)
The findings suggest that THC-7-oic acid probably acts by mechanisms similar to the NSAIDs and that the above mentioned experimental conditions can greatly influence the outcome of studies with this agent. (semanticscholar.org)
and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn). (medlineplus.gov)

Moreover, in vivo anti-inflammatory evaluation for some newly synthesized compounds has been investigated. (sohag-univ.edu.eg)
The in vivo anti-inflammatory activity revealed that the compounds possessed moderate to excellent anti-inflammatory activity. (bvsalud.org)
All compounds were evaluated for their in vivo anti-inflammatory and analgesic activities in mice. (hacettepe.edu.tr)

Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a pooled analysis of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry . (brightsurf.com)

We explored the possibility that this effect was due to their well-known anti-inflammatory actions by giving various nonsteroidal inhibitors of arachidonate metabolism to groups of mice that had received 19 Gy to the thorax (bilaterally). (allenpress.com)
Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile. (bvsalud.org)
Major obstacles faced by the use of nonsteroidal anti-inflammatory drugs ( NSAID ) are their gastrointestinal toxicity induced by non-selective inhibition of both cyclooxygenases (COX) 1 and 2 and their cardiotoxicity associated with a certain class of COX-2 selective inhibitors. (bvsalud.org)
In summary, we discovered a novel class of selective COX-1 inhibitors that could be effectively used as potential anti-inflammatory agents . (bvsalud.org)

In the current COVID-19 pandemic, there has been concern regarding the use of ibuprofen and other nonsteroidal anti-inflammatory agents by COVID-19 infected patients. (lww.com)
Using a carrageenan-induced mice of hind paw edoema, we investigated the synthesized compounds' potential anti-inflammatory activity in contrast to their parent molecule, ibuprofen. (ekb.eg)
In an effort to establish new candidates with improved analgesic and anti-inflammatory activities and lower ulcerogenic risk, a series of thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one derivatives of ibuprofen were synthesized. (hacettepe.edu.tr)

These agents have analgesic, anti-inflammatory, and antipyretic properties. (medscape.com)
Explain the differences between anti-inflammatory x antipyretic x analgesic agents. (essaypanther.com)

Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin, forestomach, and colon when it is administered during initiation and/or postinitiation stages. (aacrjournals.org)
Apoptotic, antioxidant and anti-inflammatory agent. (abcam.com)
From the blog section of your webpage titled "Can Crocin Protect as an Antioxidant and Anti-inflammatory Agent Against Coronavirus (COVID-19)? (fda.gov)

Omega-3 fatty acids , which are abundant in fatty fish such as cod, are among the most potent anti-inflammatory supplements. (medicalnewstoday.com)
Like many prescription anti-inflammatory medications, omega-3 fatty acids and fish oil may increase the risk of bleeding. (medicalnewstoday.com)

Since 5-ASAs are a mainstay treatment for inflammatory bowel disease, the authors review the pharmacology of both classes of drugs and discuss the potential relevance of 5-ASAs in the ongoing discussion of medication use in patients infected with COVID-19. (lww.com)

Synthesis and anti-inflammatory study of novel N-substituted hydroacridine-1,8-diones and bis-hexahydroacridine-1,8-dione derivatives. (sohag-univ.edu.eg)

To ward off the pain of inflammation, anti-inflammatory medication is prescribed by doctors all over the world, but the best natural anti-inflammatory agents are systemic enzymes (also known as metabolic enzymes). (naturalnews.com)
Why are systemic enzymes safer than over the counter pain killers and anti-inflammatory therapies? (naturalnews.com)
Individuals seeking systemic enzyme therapy as an anti-inflammatory treatment should speak to their doctors about which brands are the most effective and should follow the directions on the label. (naturalnews.com)
For people that are in need of a safe anti-inflammatory, systemic enzymes are the wonderful method of treatment. (naturalnews.com)

Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. (ijpsonline.com)
Anti-inflammatory medications help fight pain and chronic inflammation . (medicalnewstoday.com)
Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: allergic corneal marginal ulcers, herpes zoster ophthalmicus, anterior segment inflammation, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, chorioretinitis, optic neuritis, iritis and iridocyclitis. (nih.gov)
Asthma is a chronic inflammatory disease of the airways. (biomedcentral.com)

Recent studies suggest that the pathogenesis of different inflammatory diseases also involves the inflammasomes, intracellular multiprotein complexes that mediate activation of inflammatory caspases thereby inducing the secretion of proinflammatory cytokines. (hindawi.com)
Melatonin is an important antioxidant and also a widespread anti-inflammatory molecule, modulating both pro- and anti-inflammatory cytokines in different pathophysiological conditions. (hindawi.com)

This volume examines the anti-inflammatory drugs used to alter the inflammatory response in diseases of unknown cause. (elsevier.com)
Other chapters review colchicine and allopurinol as anti-inflammatory drugs for gout. (elsevier.com)
Non-steroidal anti-inflammatory drugs : views and expert opinions of an IARC Working Group on the Evaluation of Cancer Preventive Agents, Lyon, 2-8 April 1997. (who.int)
Compounds 5, 6, 12, 16 and 17 were investigated as anti-inflammatory and analgesic drugs. (ekb.eg)
Nonsteroidal anti-inflammatory drugs (HR = 1.45, 95% CI = 1.22, 1.72) and loop diuretics (HR = 1.33 95% CI = 1.08, 1.63) were associated with risk of progressive hearing loss over 10 years. (cdc.gov)

A portion of the work done by investigators interested in separating the medicinal properties of marijuana from its psychoactive effects is reviewed, finding several marijuana constituents, the carboxylic acid metabolites of tetrahydrocannabinol, and synthetic analogs are free of cannabimimetic central nervous system activity, do not produce behavioral changes in humans, and are effective antiinflammatory and analgesic agents. (semanticscholar.org)

Dapsone is used alone or in conjunction with other anti-inflammatory medications for treating IgA pemphigus. (medscape.com)
Olsalazine is in a class of medications called anti-inflammatory agents. (medlineplus.gov)

Topical anti-inflammatory agents should be used with caution in cases of microbial keratitis at least until effective antibiotic therapy has been instituted. (elsevier.com)

Objective: The aim of this article is to highlight antibacterial, antifungal, and anti-inflammatory activities of various phenolic compounds normally found in certain foods. (unict.it)
Compounds 5 and 6 are the best drug analogues and these compounds could be promising for anti-inflammatory agents. (ekb.eg)
The compounds carrying a 3-phenyl-2-propenylidene (1a), (biphenyl-4-yl) methylidene (1f) and (1-methylpyrrol-2-yl)methylidene (1n) at the 6th position of the fused ring have been evaluated as potential analgesic/anti-inflammatory agents without a gastrointestinal side effect. (hacettepe.edu.tr)

Part II explores the nonsteroidal anti-inflammatory agents that are peripheral analgesics and anti-pyretic. (elsevier.com)

These agents act by competitive inhibition of histamine at the H1 receptor. (medscape.com)
The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes. (ijpsonline.com)
N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. (biomedcentral.com)

Some research suggests that zinc is a potent anti-inflammatory that may support the immune system and reduce several markers of inflammation. (medicalnewstoday.com)
Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. (nih.gov)
Crocin, the unique water-soluble carotenoid with potent … anti-inflammation effects, could be a promising natural agent to boost immune system and body defense against COVID-19. (fda.gov)

This agent inhibits depolarization of type C sensory neurons by blocking sodium channels. (medscape.com)
This agent inhibits primarily COX-2. (medscape.com)

Colchicine decreases leukocyte motility and phagocytosis in inflammatory responses. (medscape.com)

14 and 3 had pain aggravated by hunger and the use of non steroidal anti-inflammatory agents. (bvsalud.org)

Part I discusses the factors that cause the inflammation and explores the interaction of these causative agents with those therapies found to be clinically effective. (elsevier.com)
This is not the only function of enzymes, though, as they also work to decrease inflammation - a function that has allowed them to become a very popular natural anti-inflammatory treatment. (naturalnews.com)
An emerging body of evidence suggests that inflammation contributes to the development of major depression, but the results of clinical trials using various anti-inflammatory agents to treat the condition have proved inconclusive. (brightsurf.com)
The inflammation process is activated when there is tissue damage caused by injury or trauma, it includes series of collective events to execute the inflammatory response. (microbiologynotes.org)
In this article, we describe some of the most effective anti-inflammatory supplements that people may wish to try, depending on the cause of their inflammation. (medicalnewstoday.com)
The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. (biomedcentral.com)

This agent is an industrial solvent. (medscape.com)

Antiviral agent. (abcam.com)

Nevertheless, they conclude: "The results of this systematic review suggest that anti-inflammatory agents play an antidepressant role in patients with major depressive disorder and are reasonably safe. (brightsurf.com)

4 ] [ 8 ] Some important considerations for the choice and dose of antithrombotic agents are the urgency for need of invasive procedures (e.g., for patients in the intensive care unit [ICU]), considerations for management of acute impairment of renal and liver function, and drug-drug interactions between investigational COVID-19 therapies and antithrombotic agents. (thieme-connect.de)
The most prominent drug-drug interactions with investigational COVID-19 therapies and antiplatelet agents include those occurring between lopinavir/ritonavir and agents such as clopidogrel (may need dose increase) or ticagrelor (may need dose reduction). (thieme-connect.de)
For fibrinolytic agents, which might need to be used for high-risk pulmonary embolism, ischemic stroke, and ST-elevation myocardial infarction (STEMI), there is no known risk of serious drug-drug interaction with the investigational therapies being studied in COVID-19. (thieme-connect.de)

This review, first, gives an overview concerning the growing importance of melatonin in the inflammatory-mediated pathological conditions and, then, focuses on its roles and its protective effects against the activation of the inflammasomes and, in particular, of the NLRP3 inflammasome. (hindawi.com)
And the effects are even stronger when these agents are added on to standard antidepressant treatment, the results show. (brightsurf.com)
The pooled data analysis suggested that anti-inflammatory agents were better than placebo and enhanced the effects of standard antidepressant treatment. (brightsurf.com)
And the effects were even greater when one or other of these agents was added to standard antidepressant treatment. (brightsurf.com)
The effects of other anti-inflammatory agents on microbial keratitis are unknown, but if these agents do not intensify the infection, they may be useful in the initial management of microbial keratitis by limiting ulceration and thus the size of the resultant corneal scar. (elsevier.com)
Any compound that has anti-inflammatory effects. (ebi.ac.uk)
These agents have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)
Sulfasalazine elicits anti-inflammatory effects. (medscape.com)

Finally, this volume ends with a discussion on the anti-inflammatory activity of some proteolytic enzymes of vegetable, animal, fungal, and bacterial origin. (elsevier.com)

In pneumococcal keratitis, neither anti-inflammatory agent worsened the disease. (elsevier.com)

IMSEAR at SEARO: Efficacy of medrysone as anti-inflammatory agent. (who.int)
Efficacy may be due to anti-inflammatory properties. (medscape.com)

Aspirin (ASP) is a commonly used analgesic and anti-inflammatory agent. (cdc.gov)

These agents modulate events leading to inflammatory reactions. (medscape.com)

Noni fruit puree compares favorably in analgesic and anti-inflammatory activity to tramadol and hydrocortisone, respectively, in an animal model of arthritis. (greenmedinfo.com)

Additionally, dose adjustment would be necessary for agents such as vitamin K antagonists (VKAs), apixaban, and betrixaban. (thieme-connect.de)
4 ] VKAs potentially have major drug interactions when prescribed with investigatory agents such as ribavirin, interferon, methylprednisolone, and azithromycin, which often necessitates close international normalized ratio (INR) monitoring, dose adjustment, or using alternative options. (thieme-connect.de)

Thus, based on these observations, herein we report the evaluation of anti-inflammatory activity, drug action, ulcerogenicity and cytotoxicity of a series of 5-adamantylthiadiazole-based thiazolidinone derivatives. (bvsalud.org)

PANTROFINA® BETA can be easily incorporated in the oil phase of all cosmetic preparations and is suitable as soothing agent for every personal care and make-up products. (ulprospector.com)

Anti-inflammatory agents theoretically block the inflammatory process and improve the disease conditions. (medscape.com)
When combined with effective antibiotic therapy, neither anti-inflammatory agent worsened the disease. (elsevier.com)
Drug-induced disease may be treated merely by withdrawal of the offending agent. (medscape.com)
These agents are used to improve the clinical and immunologic aspects of the disease. (medscape.com)

Periodontal host modulation with antiproteinase, anti-inflammatory, and bone-sparing agents. (bvsalud.org)

Whole genome analysis of lung, sampled 24 hours after challenge, showed expression changes of not only genes belonging to several Gene Ontology groups with up-regulation of inflammatory-associated genes and those associated with lung remodeling but also genes involved in downsizing these processes. (cdc.gov)

These agents were 52% more effective in reducing symptom severity, overall, and 79% more effective in eliminating symptoms than placebo, as measured by an average fall in depression scales of 55. (brightsurf.com)
As these two research suggested, both δ- and γ-tocotrienols may be effective, long-term anti-inflammatory agents to reduce the serious symptoms of RA. (healthtoday.net)

From the blog section of your webpage titled "Crocin as a Neuroprotective Agent Against Stroke. (fda.gov)

This text also presents an illustrative classification of some debilitating inflammatory conditions and the available therapy. (elsevier.com)

Anatomy7

Organisms14

Diseases6

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes33

Disciplines and Occupations3

Information Science4

Named Groups1

Health Care2

Geographicals2

Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment. (1/7049)

Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids. (2/7049)

Pharmacological studies on root bark of mulberry tree (Morus alba L.) (3/7049)

Analysis of Chinese herbal creams prescribed for dermatological conditions. (4/7049)

Characteristics of spontaneous erythema appeared in hairless rats. (5/7049)

Topical psoriasis therapy. (6/7049)

Altered leucocyte trafficking and suppressed tumour necrosis factor alpha release from peripheral blood monocytes after intra-articular glucocorticoid treatment. (7/7049)

A comparative study of the effects of ketotifen, disodium cromoglycate, and beclomethasone dipropionate on bronchial mucosa and asthma symptoms in patients with atopic asthma. (8/7049)

Inflammation

Okadaic Acid

Lipopolysaccharides

Transcription Factor RelA

Tumor Necrosis Factor-alpha

Inflammation Mediators

I-kappa B Kinase

I-kappa B Proteins

NF-kappa B

Interleukin-1

Tetradecanoylphorbol Acetate

Macrophages

Cells, Cultured

Gene Expression Regulation

Tropaeolaceae

Stereoisomerism

Magnetic Resonance Spectroscopy

Nucleic Acid Conformation

Molecular Conformation

Molecular Structure

Models, Molecular

Hydrogen Bonding

Guanine

Heterocyclic Compounds, Bridged-Ring

Base Pairing

Pachyrhizus

Deoxyguanosine

Plant Extracts

Deoxycytosine Nucleotides

Guanosine

DNA

G-Quadruplexes

Antibodies

Immunoglobulin G

Oligodeoxyribonucleotides

India

Deoxyadenine Nucleotides

Inosine

Enzyme-Linked Immunosorbent Assay

7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

Freund's Adjuvant

Crystallography, X-Ray

Sulfolobus solfataricus

DNA Adducts

Plants, Medicinal

Molecular Sequence Data

X-Ray Diffraction

Phytotherapy

Base Composition

Alkenes

Deoxyadenosines

Nucleosides

Antibody Specificity

Hepatitis C Antibodies

Immunoglobulin M

Isomerism

2-Acetylaminofluorene

Base Sequence

Oxytocics

Solutions

Protons

DNA Polymerase beta

Benzo(a)pyrene

Dinucleoside Phosphates

Structure-Activity Relationship

Photochemistry

Oligonucleotides

Binding Sites

Bacteriorhodopsins

Glycosides

Molecular Mimicry

Immunoglobulin Fab Fragments

Hepatitis C

Kinetics

Spectrum Analysis, Raman

Thermodynamics

Antibodies, Antinuclear

Hepatitis B

Nucleotides

Mice, Inbred ICR