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Urinary tract infections in adults. (1/205)
Urinary tract infections remain a significant cause of morbidity in all age groups. Recent studies have helped to better define the population groups at risk for these infections, as well as the most cost-effective management strategies. Initially, a urinary tract infection should be categorized as complicated or uncomplicated. Further categorization of the infection by clinical syndrome and by host (i.e., acute cystitis in young women, acute pyelonephritis, catheter-related infection, infection in men, asymptomatic bacteriuria in the elderly) helps the physician determine the appropriate diagnostic and management strategies. Uncomplicated urinary tract infections are caused by a predictable group of susceptible organisms. These infections can be empirically treated without the need for urine cultures. The most effective therapy for an uncomplicated infection is a three-day course of trimethoprim-sulfamethoxazole. Complicated infections are diagnosed by quantitative urine cultures and require a more prolonged course of therapy. Asymptomatic bacteriuria rarely requires treatment and is not associated with increased morbidity in elderly patients. (+info)A trial comparing low-dose, short-course ciprofloxacin and standard 7 day therapy with co-trimoxazole or nitrofurantoin in the treatment of uncomplicated urinary tract infection. (2/205)
The study was undertaken to compare the safety and efficacy of twice-daily ciprofloxacin for 3 days with standard 7 day therapy with either co-trimoxazole or nitrofurantoin in the treatment of women with acute, uncomplicated urinary tract infections (UTI). This multicentre, prospective, randomized, double-blind trial compared oral ciprofloxacin (100 mg bd) for 3 days with co-trimoxazole (160/800 mg bd) or nitrofurantoin (100 mg bd) for 7 days. Bacteriological and clinical evaluations were performed at study entry, during therapy and 4-10 days and 4-6 weeks after the completion of therapy. The primary efficacy parameter was eradication of the causative organism 4-10 days following treatment. Of 713 women enrolled and evaluable for safety, 521 were evaluable for efficacy (168 ciprofloxacin, 174 co-trimoxazole, 179 nitrofurantoin). Escherichia coli (83%) was the most frequently isolated pathogen in all treatment groups. Bacteriological eradication was reported in 88% of ciprofloxacin patients, 93% of co-trimoxazole patients and 86% of nitrofurantoin patients. At the 4-6 week follow-up, ciprofloxacin had statistically significantly higher eradication rates (91%) than co-trimoxazole (79%; 95% confidence limit (CL) = -20.6%, -3.9%) and nitrofurantoin (82%; 95% CL = -17.1%, -0.9%). Clinical resolution 4-10 days after therapy and at the 4-6 week follow-up was similar among the three treatment groups. The overall incidence of treatment-emergent adverse events was not significantly different (P = 0.093) among the three drug regimens, although co-trimoxazole was associated with a greater number of adverse events than ciprofloxacin (P < or = 0.05). Ciprofloxacin also caused fewer episodes of nausea than either of the other agents (P < or = 0.01). (+info)Risk factors for resistance to "first-line" antimicrobials among urinary tract isolates of Escherichia coli in children. (3/205)
BACKGROUND: There are increasing concerns regarding antimicrobial resistance in Canada. Data are limited on the prevalence, patterns of resistance and risk factors associated with resistant organisms, including coliforms, in children. This study was done to address these issues as they relate to urinary tract isolates of Escherichia coli in a tertiary care pediatric centre in Ottawa. METHODS: A surveillance study was conducted from December 1992 to December 1994. Susceptibility testing of urinary tract isolates of E. coli was performed using a panel of antimicrobial agents. A case-control study was also conducted for subjects with isolates resistant to trimethoprim-sulfamethoxazole (T-S), this drug being used a representative "first-line" agent. RESULTS: A total of 1636 consecutive isolates were obtained from 967 subjects. Of the 1636 isolates, 736 (45.0%) were resistant to ampicillin, 514 (31.4%) were resistant to T-S, 363 (22.2%) were resistant to both ampicillin and T-S, and 27 (1.7%) were resistant to both ampicillin and gentamicin. In the case-control study 274 children with isolates resistant to T-S were matched with 274 children who had T-S-sensitive isolates obtained during the study period or the preceding or subsequent 6 months. Multivariate analyses indicated that subjects who had received antimicrobials for more than 4 weeks in the previous 6 months were about 23 times more likely to have isolates resistant to T-S than were subjects without this risk factor (odds ratio [OR] 23.4, 95% confidence interval [CI] 12.0-47.6). Children with genitourinary tract abnormalities were 2.4 times more likely to have resistant isolates than those without such abnormalities (95% CI 1.2-4.5). Compared with children who had no hospital admissions in the previous year, those with 1 admission in that period were more likely to have resistant isolates (OR 2.3, 95% CI 1.4-7.5), as were those with 2 or more admissions in that period (OR 3.2, 95% CI 1.1-4.8). Compared with children aged 2-6 years, children under 2 years of age were less likely to have resistant isolates (OR 0.3, 95% CI 0.2-0.8). INTERPRETATION: Selective antimicrobial pressure and multiple admissions to hospital were among the risk factors associated with antimicrobial resistance. The finding of a low but definite level of resistance to both ampicillin and gentamicin is important for the selection of empiric therapy for sepsis in neonates. The role of inexpensive first-line agents in the outpatient treatment and prevention of urinary tract infections requires re-examination, particularly in children who have recently received antimicrobial therapy. (+info)Recurrent cystitis in nonpregnant women. (4/205)
Consistent evidence from RCTs shows that antibiotic prophylaxis (either continuous or postcoital), using trimethoprim TMP-SMZ, nitrofurantoin, or a quinolone, reduces infection rates in women with high rates of recurrent cystitis (at least two per year). Limited evidence suggests that intermittent patient-administered treatment (taken at the onset of symptoms) is an effective alternative management strategy to continuous antibiotic prophylaxis in women with high rates of infection (at least two per year). Limited evidence suggests that long-term prophylaxis is likely to benefit women with a baseline rate of more than two infections per year over many years. However, long-term treatment has not yet been evaluated in RCTs. In women who experience recurrent, uncomplicated cystitis, there is no evidence to support routine investigation of the urinary tract with excretory urography, ultrasonography, cystoscopy, or voiding cystourethrography. No specific subgroups of women who would clearly benefit from investigation have yet been adequately defined. (+info)Factors associated with trimethoprim-resistant bacteria isolated from urine samples. (5/205)
Urine samples with trimethoprim-resistant or trimethoprim-sensitive Gram-negative bacteria and samples with no bacterial growth (NG) were identified. Age-sex matched community controls were generated with each trimethoprim-resistant case. These four groups were evaluated for exposure. Prior trimethoprim use was significantly more common in the trimethoprim-resistant group when compared with the trimethoprim-sensitive or the NG group. Prior hospitalization was significantly less common in the trimethoprim-resistant than the trimethoprim-sensitive group, but not with the NG group. Prior oestrogen exposure was associated with trimethoprim resistance. There were no associations found for diabetes or prior corticosteroid exposure. Community controls were found to be inappropriate controls for the study of trimethoprim-resistant bacteria in urine samples. (+info)Antimicrobial resistance patterns in urinary isolates from nursing home residents. Fifteen years of data reviewed. (6/205)
The antibiotic resistance patterns of gram-negative bacteria isolated from nursing home patients between 1983 and 1997 were analysed. Escherichia coli was the most prevalent isolate (48%) followed by Proteus spp. (26%) and other Enterobacteriaceae (20%). During the study period, the susceptibility of E. coli decreased for co-trimoxazole (79% to 62%), increased for nitrofurantoin (79% to 91%) and remained unchanged for amoxycillin (41%). Susceptibility to norfloxacin, available from 1990, decreased from 87% to 71%. Similar trends were observed when the susceptibilities of all gram-negative urinary pathogens were combined. The changes in susceptibility can probably be attributed to the empirical prescribing practices in the nursing homes studied. (+info)Variation by specialty in the treatment of urinary tract infection in women. (7/205)
To determine practicing physicians' strategies for diagnosing and managing uncomplicated urinary tract infection, we surveyed physicians in general internal medicine, family practice, obstetrics and gynecology, and emergency medicine in four states. Responses differed significantly by respondents' specialty. For example, nitrofurantoin was the antibiotic of first choice for 46% of obstetricians, while over 80% in the other specialties chose trimethoprim-sulfamethoxazole. Most surveyed said they do not usually order urine culture, but the percentage who do varied by specialty. Most use a colony count of 10(5) colony-forming units or more for diagnosis although evidence favors a lower threshold, and 70% continue antibiotic therapy even if the culture result is negative. This survey found considerable variation by specialty and also among individual physicians regarding diagnosis and treatment of urinary tract infection and also suggests that some of the new information from the literature has not been translated to clinical practice. (+info)Trimethoprim-sulfamethoxazole resistance among urinary coliform isolates. (8/205)
OBJECTIVE: A large majority of urinary tract infections are caused by coliform organisms. Trimethoprim-sulfamethoxazole (TMP-SMX) resistance among uropathogens is increasing in many areas. The objective of this study was to determine risk factors for TMP-SMX-resistant coliforms in patients with urinary tract infections. DESIGN: Retrospective case-control study. SETTING: Emergency department of a tertiary care university hospital. PATIENTS: We studied 448 emergency department patients aged 14 years or older with a urinary tract infection caused by a coliform organism. Cases consisted of all patients with a culture-documented urinary tract infection caused by a TMP-SMX-resistant coliform, while control patients were those with a TMP-SMX-sensitive organism. MEASUREMENTS AND MAIN RESULTS: A univariate analysis of clinical variables associated with TMP-SMX resistance was performed. Multiple logistic regression was performed to determine independent predictors of TMP-SMX resistance. Resistance to TMP-SMX was seen in 15% of isolates. Numerous variables were associated with TMP-SMX resistance on the univariate screen. Independent predictors of resistance were diabetes (odds ratio [OR] 3.1; 95% confidence interval [CI] 1.2, 8.4), recent hospitalization (OR 2.5; 95% CI 1.1, 5.7), current use of antibiotics (OR 4.5; 95% CI 2.0, 10.2), and recent use of TMP-SMX (OR 5.1; 95% CI 2.2, 11.5). When those with recent hospitalization were excluded from analysis, independent predictors were current use of any antibiotic (OR 3.5; 95% CI 1.4, 8. 4) and recent use of TMP-SMX (OR 5.9; 95% CI 2.4, 14.3). CONCLUSIONS: Coliforms resistant to TMP-SMX are common in our emergency department. Diabetes, recent hospitalization, and the use of antibiotics, particularly the use of TMP-SMX, are independent risk factors for TMP-SMX resistance. Clinicians should consider these findings when deciding on antimicrobial therapy for patients with urinary tract infections. (+info)
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- Zavicefta received European Commission approval for complicated urinary tract infections (cUTI), complicated intra-abdominal infections (cIAI), hospital acquired pneumonia/ventilator associated pneumonia (HAP/VAP) and 'treatment of aerobic gram negative infections in adult patients with limited treatment options on June 28, 2016. (businesswire.com)
- Nabriva Therapeutics is also developing CONTEPO™ (fosfomycin) for injection, a potential first-in-class epoxide antibiotic for complicated urinary tract infections (cUTI), including acute pyelonephritis. (nabriva.com)
- The US Food and Drug Administration (FDA) has approved the use of a new antibiotic, ceftolozane plus tazobactam (Zerbaxa), for the treatment of adults with complicated intra-abdominal infections and complicated urinary tract infections. (pharmaceutical-journal.com)
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- Use of anti-infective agents during lactation: Part 1--Beta-lactam antibiotics, vancomycin, quinupristin-dalfopristin, and linezolid. (nih.gov)
- The Surgical Infection Society recommends starting prophylactic antibiotics before surgery, using appropriate spectrum agents for less than 24 hours for nonperforated appendicitis and for less than 5 days for perforated appendicitis. (medscape.com)
- A combination of nasturtium herb and horseradish root is as effetive in treating acute sinusitis, acute bronchitis and acute urinary tract infections as comparable to treatment with standard antibiotics. (greenmedinfo.com)
- Zavicefta specifically addresses multi-drug resistant Gram-negative infections, including those resistant to carbapenem antibiotics, one of the most significant unmet medical needs in bacterial infections treated with hospital anti-infectives. (businesswire.com)
- Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression. (fpnotebook.com)
- Many antibiotics concentrate in the urine and may be used to treat urinary tract infections (UTIs) even when nonsusceptible by in vitro testing. (mhmedical.com)
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Antimicrobial Agents11
- During the past six decades antimicrobial agents have played a critical role in reducing the burden of communicable diseases all over the world. (who.int)
- Improper utilization of antimicrobial agents especially in high disease-burden settings and for non-therapeutic use as in the veterinary sector result in strong selection pressure that allows the resistant strain to grow and rapidly replace the susceptible isolates. (who.int)
- In that sense, antimicrobial resistance is a global challenge requiring concerted efforts at national and international levels to preserve the available antimicrobial agents. (who.int)
- This is possible through treatment policies such as combination therapy, rational prescription, patient adherence, strong regulatory mechanism and educational activities, along with an efficient surveillance system that monitors the emergence and spread of resistance, as well as the utilization of antimicrobial agents. (who.int)
- The regional strategy aims to give particular attention to interventions involving the introduction of legislation and policies governing the use of antimicrobial agents, establishing laboratory-based networks for surveillance of resistance and ensuring the rational use of these drugs at all levels of health-care settings. (who.int)
- The effective implementation of this strategy by various national disease control programmes will lead to reduction in the morbidity and mortality due to antimicrobial-resistant infection, and preserve the effectiveness of antimicrobial agents in the treatment and prevention of microbial infections. (who.int)
- Mankind's fight against these diseases is also largely dependent upon the efficacy of specific antimicrobial agents that, during the past seven decades, saved millions of lives, substantially reduced the burden of diseases and improved the quality and longevity of life. (who.int)
- Concomitant nonfungal infections were present in 85%, 90% had received antimicrobial agents, and 83.2% had urinary tract drainage devices. (elsevier.com)
- The MICs of various antimicrobial agents for such mutant strains increases with each additional mutation in the target sites. (cdc.gov)
- At the time of the survey, 103 (5.2%) of the 1,978 children were reported to be taking antimicrobial agents. (cdc.gov)
- It is also a natural antiseptic as it contains antimicrobial agents that kill bacteria. (33drugs.eu)
UTIs5
- We will include women aged ≥ 70 years with recurrent UTIs, defined as ≥ 3 episodes of antibiotic treated acute cystitis (acute symptoms specific/related to the urinary tract) during the last twelve months or ≥ 2 episodes during the last six months. (clinicaltrials.gov)
- Factors that might contribute to the development of UTIs include excessive immunosuppression, and instrumentation of the urinary tract (e.g. urethral catheters and ureteric stents). (nih.gov)
- Urinary tract infections (UTIs) are common in females, accounting for over 6 million patient visits to physicians per year in the United States. (medscape.com)
- Since bacterial clearance from the urinary tract is dependent on urine output, it was hypothesized that ACEi may also increase the risk of urinary tract infections (UTIs). (ox.ac.uk)
- Acute Uncomplicated Urinary Tract Infections (UTIs): 50 mg four times daily for seven days. (medicines.org.uk)
Potential applications as anti-infective2
- Cancer cell 5:489 501 regulator and potential applications as anti-infective isreal precription without get can metformin in agents , acute and well characterized in-vivo. (journeysmobilevet.com)
- Adrenaline can decrease the intraocular pressure during mini-percutaneous nephrolitholapaxy: An in-vitro pressure- measurement and potential applications as anti-infective agents , harrington m, carpenter mk, keirstead 23(2):419 414 hs (2001) human embryonic stem cells: Their advantages and limitations of laparoscopic skills such as in sickle cell disease (scd). (journeysmobilevet.com)
Uncomplicated urinary tract inf2
Pneumonia3
- Cotrimoxazole Tablets 960mg Cotrimoxazole Tablets 960mg are widely used to treat certain bacterial infections such as pneumonia, bronchitis and infections of the urinary tract, ears and intestines. (medicoremediesindia.net)
- [6] Nosocomial infections can cause severe pneumonia and infections of the urinary tract , bloodstream and other parts of the body. (wikipedia.org)
- This medication is a fluoroquinolone antibiotic, prescribed for certain types of bacterial infections such as pneumonia, urinary tract, skin, bones and joint infections. (medplusmart.com)
Bacteria10
- Urinary Tract Infection (UTI) occurs due to inflammation of the urinary tract including bladder, urethra and kidneys by invading gram-negative bacteria especially E. coli. (eurekaselect.com)
- Urinary Tract Infection: An Infection Caused by Gram-Negative Bacteria especially E. coli, Bacterial Diseases (2020) 1: 176. (eurekaselect.com)
- Nitrofurantoin, a nitrofuran antibacterial agent, is available in microcrystalline and macrocrystalline form to treat urinary tract infections caused by many gram-negative and some gram-positive bacteria. (pharmacycode.com)
- Oral nitrofuran antibacterial agent specifically used to treat urinary tract infections caused by many gram-negative and some gram-positive bacteria. (pdr.net)
- cases of Urosepsis with Actinobaculum schaalii and Aerococcus urinae.J. Aerococcus urinae and the other bacteria in the Aerococcus genus are emerging Another important part of research is the diagnosis of infective endocarditis, Aerococcal infections : - from bedside to bench and back. (netlify.app)
- Infective agents like bacteria, viruses and their toxins. (yamunapharmacy.com)
- Antimicrobial Activity of Five Essential Oils against Bacteria and Fungi Responsible for Urinary Tract Infections. (zanehellas.com)
- But they are not without their risks of side effects: as the name anti-biotic implies, these medications kill bacteria. (allergyresearchgroup.com)
- Infection to the urinary tract includes the kidneys, bladder, ureters or urethra is called urinary tract infection caused by bacteria. (drugcarts.com)
- Pyosan® Gum Paint contains Potassium Iodide and Iodine that acts as antiseptic and anti-infective that kills bacteria. (okdermo.com)
Cystitis4
- The leaves and leaf extracts from uva ursi are used in non-prescription medicinal products mainly to treat urinary tract infection, cystitis, kidney stones, and as a diuretic. (nih.gov)
- The leaves are used in medicinal products to treat urinary tract infection, cystitis, and kidney stones. (nih.gov)
- It is indicated for the treatment of uncomplicated urinary tract infections (i.e. cystitis) due to either E. coli or E. faecalis in women. (medscape.com)
- For the treatment of complicated urinary tract infection (UTI), including pyelonephritis, as well as cystitis† and pyelonephritis due to resistant gram-negative organisms. (pdr.net)
Drugs8
- One of the most critical factors that will facilitate elimination of these diseases is availability of effective antimicrobial drugs against the causative agents. (who.int)
- 3. Unfortunately in the recent past, the emergence and spread of resistance in several microorganisms have rendered the management of many infectious diseases difficult, using the common anti-infective drugs. (who.int)
- OpenUrlCrossRefSchwarz A, Perez-Canto A. Nephrotoxicity of antiinfective drugs. (food-planner.xyz)
- A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. (nih.gov)
- with red-tape and funding restrictions creating hindrances to the progress of anti-infective drugs through trial and regulatory approvals processes. (smi-online.co.uk)
- Reply to: impact of Chronic Hepatitis C virus co-infection on outcomes of infective endocarditis in people who inject drugs. (amedeo.com)
- he can t get fooled by believing that for a while, but the exercising stops, pain begins to mount immediately and last of these anti-malarial drugs are also called simply masochism, a term used frequently by sigmund freud expressed his ideas about erotogenic zones in a. (dsaj.org)
- To explore the possibilities of using linezolid and moxifloxacin drugs for the treatment of NTM disease, we have collected 98 NTM clinical isolates to detect and compare the minimal inhibitory concentration (MIC) of the two antiinfective drugs. (alliedacademies.org)
Aminoglycosides1
- Our experience with this case indicates that long-term use of a combination of β-lactam and aminoglycosides might represent a suitable management option for future infective endocarditis cases due to non-Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella spp. (curehunter.com)
Analgesics2
- Sometimes you have to use narcotic analgesics.Ivermectin is a medication used to treat parasite infestations.Ivermectin is an anthelmintic (anti-parasite) used to treat infections caused by certain parasites. (2pstart.com)
- Skin side effects of non-steroidal anti-inflammatory analgesics and so-called minor analgesics. (dbcls.jp)
Endocarditis10
- Aerococcus urinae is a rare cause of urinary tract infections, mainly in elderly men Here we present the first case of an A. urinae endocarditis diagnosed by Jun 6, 2017 ABSTRACT. (netlify.app)
- Introduction: Aerococcus urinae is a rare cause of infective endocarditis. (netlify.app)
- Granulicatella adiacens (2) treatment of patients with infective endocarditis (IE) should be directed by a 84 - Infectious diseases HANDOC: a handy score to determine the need for echocardiography in Aerococcus urinae Endocarditis: Not So Severe After All? (netlify.app)
- Aspects of infective endocarditis. (netlify.app)
- abstract = "Aerococcus urinae is an emerging pathogen that causes urinary tract infections, bacteremia and infective endocarditis. (netlify.app)
- English abstract · Humans A case of suspected infective endocarditis with Lactococcus garvieae: lack of in vitro synergy Aerococcus urinae Endocarditis: Not So Severe After All? (netlify.app)
- Item request has Five patients with A. urinae bacteremia were diagnosed with infective endocarditis. (netlify.app)
- [email protected] One of the rare bacterial species recently associated with biofilms and negative cultures in infective endocarditis is Aerococcus urinae. (netlify.app)
- Background: Aerococcus urinae has lately been acknowledged as a cause of infective endocarditis (IE) especially in older males with underlying urinary tract disorders. (netlify.app)
- Se hela listan på academic.oup.com A rare case of Aerococcus urinae infective endocarditis in an atypically young male: case report and review of the literature Joseph M. Yabes1*, Serafim Perdikis2, David B. Graham3 and Ana Markelz1 Abstract Background: Aerococcus urinae is a gram-positive, alpha-hemolytic coccus bacterium primarily implicated in less de Jong MF, Soetekouw R, ten Kate RW, et al. (netlify.app)
Recurrent Urinary Tract Inf2
- Recurrent urinary tract infection (UTI) in elderly women is a major driver of antibiotic prescription. (clinicaltrials.gov)
- D-mannose appears protective for recurrent urinary tract infection. (greenmedinfo.com)
Bladder3
- Muscarinic agonists are most commonly used when it is desirable to increase smooth muscle tone, especially in the GI tract, urinary bladder and the eye. (nih.gov)
- Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (nih.gov)
- Endoscopic diagnosis and treatment in urinary bladder pathology : handbook of endourology / edited by Petrisor A. Geavlete. (pitt.edu)
Antibacterial2
- Levofloxacin, the optically pure levorotatory isomer of ofloxacin, is a fluoroquinolone antibacterial agent. (nih.gov)
- The mechanism of action is not clear, but it appears that sulfasalazine and its metabolites have immunosuppressive , antibacterial, and anti-inflammatory effects. (wikipedia.org)
Substances2
- Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (nih.gov)
- Substances that prevent infectious agents or organisms from spreading or kill infectiou. (drugbank.com)
Antibiotic7
- Antibiotic agents are effective in decreasing the rate of postoperative wound infection and in improving outcome in patients with appendiceal abscess or septicemia. (medscape.com)
- Gentamicin is an aminoglycoside antibiotic used for gram-negative coverage, as well as in combination with an agent against gram-positive organisms and another one against anaerobes. (medscape.com)
- Methenamine hippurate acts via the production of formaldehyde from hexamine, which in turn acts as a bacteriostatic agent, therefore methenamine hippurate is not defined as an antibiotic. (clinicaltrials.gov)
- Individuals prescribed an antibiotic in primary care for a respiratory or urinary infection develop bacterial resistance to that antibiotic. (greenmedinfo.com)
- While recently approved antibiotic agents will likely help stem AMR crisis, novel approaches to the prevention and treatment of MDR infections are needed to ensure a viable antimicrobial armamentarium for the future. (smi-online.co.uk)
- Ciprofloxacin (Cipro) is another broad-spectrum antibiotic, effective in the treatment of mild infections of the urinary tract and sinuses. (thefreedictionary.com)
- And although this can be quite helpful, say, in the case of killing the E. coli that's causing a urinary tract infection before it can crawl up into the kidneys and wreak havoc there, antibiotic medications are not particularly discerning in what strains they kill, or where. (allergyresearchgroup.com)
Acute urinary tract infe1
- Acute Urinary Tract Infections: 3mg/kg day in four divided doses for seven days. (medicines.org.uk)
Topical6
- Bactericidal cationic quaternary ammonium surfactant used as a topical anti-infective agent. (bireme.br)
- Arbutin is usually known to be non-phenol, it is a safer alternative to the topical hydroquinone and penetration can be increased when combined with other dermatological agents. (capefearcouncilbsa.org)
- It is a topical anti-infective. (web.app)
- Silver Nitrate is a prescription topical solution used in treating wounds and burns on the skin as an anti-infective agent. (web.app)
- Topical application, in the form of creams, lotions, gels, solutions, etc., largely avoids side effects of the agents and permits high level concentrations of the agents. (justia.com)
- Pyosan® Gum Paint is a topical solution that contains antiseptic agents combined with tanning agents. (okdermo.com)
Medicinal Chemistry2
- Anti-Infective Agents in Medicinal Chemistry was launched in 2002 and later renamed in 2010 as Anti-Infective Agents. (benthamscience.com)
- Our strategies for creating new anti-infective agents involve interdisciplinary research in the continuum of organic, biological and medicinal chemistry. (hopkinsmedicine.org)
Cystic1
- Biofilms within the host are implicated in serious and persistent infectious diseases including cystic fibrosis, chronic otitis media, and urinary tract infection. (cegelskilab.com)
Disorders2
- Antidepressants are psychotropic agents used for some aggression and behavioral disorders. (ratguide.com)
- During this period, exposure an exposure assess- surface contamination picking objects, bending metal tubes, hammering) personal enclosure localised controls (e.G. These are the complexing agent and 170,000 to 540.0 particles: Thus, only patients behavioral disorders with depression, benzodiaze- depression. (equalitymi.org)
Symptomatic urinary5
- In this 2-year, multisite, randomized, placebo-controlled trial involving 607 children with vesicoureteral reflux that was diagnosed after a first or second febrile or symptomatic urinary tract infecton, we evaluated the efficacy of Trimethoprim-Sulfamethoxazole (TMP-SMZ) prophylaxis in preventing recurrences (primary outcome). (clinicaltrials.gov)
- There is substantial uncertainty in the diagnosis of symptomatic urinary infection in this population. (infectiousdiseaseadvisor.com)
- If acute localizing genitourinary signs or symptoms are not present, symptomatic urinary tract infection is unlikely in the non-catheterized resident. (infectiousdiseaseadvisor.com)
- Chronic genitourinary symptoms, such as incontinence, frequency, or nocturia, are consistent with symptomatic urinary infection only when there is acute deterioration. (infectiousdiseaseadvisor.com)
- Although loss of the estrogen effect on the genitourinary mucosa has been suggested to contribute to urinary infection in post-menopausal women, evidence to date does not support estrogen deficiency as an important factor contributing to bacteriuria or symptomatic urinary infection for female residents of nursing homes. (infectiousdiseaseadvisor.com)
Risk of urinary tract infe1
- This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of urinary tract infections. (greenmedinfo.com)
Infectious diseases3
- 2. Apart from public health disease control programmes, infectious diseases exert significant mortality and morbidity as outcomes of acute infectious diseases including diarrhoeal diseases, respiratory infections, sexually transmitted infections, urinary tract infections and wound infections acquired in communities or in hospital settings. (who.int)
- Included are the discovery and development of anti-infective agents and vaccines for the prevention and treatment of infectious diseases, antimicrobial resistance, and control strategies which cover all investigative aspects of vectors associated with disease transmission. (nih.gov)
- Reviews grant applications broadly focused on infectious diseases and immunology, addressing the immune system's role in host interactions with infectious agents and the mechanisms and treatment of diseases when the immune system has a major role, including autoimmunity, immune-mediated diseases, and immune tolerance. (nih.gov)
Treatment8
- The use of long-term antimicrobial prophylaxis is controversial, however, as it might increase the likelihood of infective organisms becoming resistant to treatment. (nih.gov)
- Angiotensin-converting enzyme inhibitor treatment and the development of urinary tract infections: a prescription sequence symmetry analysis. (ox.ac.uk)
- other anti-infectives are used for treatment of staphylococcal respiratory tract infections. (drugs.com)
- Oral bacitracin not recommended as a preferred or alternative agent for treatment of C. difficile infection (CDI) or CDAD. (drugs.com)
- For the treatment of and prophylaxis against acute or recurrent, uncomplicated lower urinary tract infections or pyelitis either spontaneous or following surgical procedures. (medicines.org.uk)
- Nitrofurantoin may be used with caution as short-course therapy only for the treatment of uncomplicated lower urinary tract infection in individual cases with an eGFR between 30-44 ml/min to treat resistant pathogens, when the benefits are expected to outweigh the risks. (medicines.org.uk)
- We expect final top-line data from our Phase 3 clinical trial for the treatment of complicated urinary tract infection (cUTI) in the third quarter of 2020. (sperotherapeutics.com)
- Actv 24, the latest in the anti-allergic treatment profile has gained acceptance within a short period of launch and has started gaining prescriptions among specialist. (jagsonpal.com)
Therapy6
- Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations. (greenmedinfo.com)
- Hemorrhage during warfarin therapy associated with cotrimoxazole and other urinary tract anti-infective agents: a population-based study. (food-planner.xyz)
- For long-term suppressive therapy for urinary tract infection (UTI) prophylaxis in patients predisposed to urinary tract infection. (pdr.net)
- This is Jagsonpal's newest addition among the anti-allergy therapy area that is gaining wide acceptance and provides relief from allergic symptoms like allergic rhinitis, seasonal allergies, along with relieving symptoms of swelling and itching. (jagsonpal.com)
- Previously untreated follicular, CD20-positive, B-cell NHL in combination with first line chemotherapy and, in patients achieving a complete or partial response to a rituximab product in combination with chemotherapy, as single-agent maintenance therapy. (nih.gov)
- Expert Review of Anti-infective Therapy (2015) 13 (2): 209. (aap.org)
Oral7
- Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as tablets for oral administration. (nih.gov)
- SPR994 is our oral carbapenem being developed to help patients with serious urinary tract infections go home and stay home from the hospital. (sperotherapeutics.com)
- Study 3 ) highlight the need to demonstrate potency of an oral versus and IV agent. (sperotherapeutics.com)
- Aerococcus urinae was first described as an Aerococcus-like organism (ALO) by Colman et al.in 1967 [2] and was found to differ from A. viridans by 16s rRNA sequencing [3].A. urinae is mainly We present the case of an elderly male who was initially seen in our hospital for a urinary tract infection that was treated with oral ciprofloxacin. (netlify.app)
- The manufac- turer recommends that levofloxacin oral solution (see colouring agents, as avourings, are used not the only variable in the preparation pro- cesses mostly results from these studies may not be administered in capsules. (equalitymi.org)
- Characterization of Herbal Antifungal Agent, Origanum vulgare against Oral Candida spp. (zanehellas.com)
- Evaluation of anti-enzyme properties of Origanum vulgare essential oil against oral Candida albicans. (zanehellas.com)
Renal3
- In addition to collecting follow-up data on urinary tract infections, renal scarring and antimicrobial resistance, quality of life, compliance, safety parameters, utilization of health resources, and change in VUR were assessed periodically throughout the study. (clinicaltrials.gov)
- Urinary tract infection (UTI) is the most common type of bacterial infection contracted by recipients of renal allografts in the post-transplantation period. (nih.gov)
- Maintain fluid intake and urinary output at proper levels to avoid renal toxicity. (drugs.com)
Nitrofurantoin1
- Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections. (fpnotebook.com)
Disinfectant properties1
- Arbutin is normally converted in the body to the form of hydroquinone, which is a phenolic agent that has antimicrobial, astringent, as well as disinfectant properties. (capefearcouncilbsa.org)
Upper urinary tract2
Inflammation1
- Inflammation is defined as the local response of human body tissues to injury due to any external or internal body agent. (yamunapharmacy.com)
Nosocomial2
- Although fungal urinary tract infections are an increasing nosocomial problem, the significance of funguria is still not clear. (elsevier.com)
- Se hizo un seguimiento retrospectivo de cohorte de las IAA en las UCI de cuatro hospitales, según las definiciones de infección nosocomial del Sistema Nacional de Vigilancia de Infecciones Nosocomiales de los Centros para el Control y la Prevención de Enfermedades (CDC-NNIS) y de la Red Nacional de Seguridad Sanitaria (NHSN), de los Estados Unidos de América. (scielosp.org)
Ofloxacin1
- Ofloxacin (urinary anti infectives) - Ofloxacin from licensed online pharmacy. (20m.com)
Commercialization4
- NEW YORK--( BUSINESS WIRE )--Pfizer Inc. (NYSE:PFE) today announced that it has entered into an agreement with AstraZeneca to acquire the development and commercialization rights to its late-stage small molecule anti-infectives business, primarily outside the United States. (businesswire.com)
- The agreement includes the commercialization and development rights to the newly approved EU drug Zavicefta™ (ceftazidime-avibactam), the marketed agents Merrem™/Meronem™ (meropenem) and Zinforo™ (ceftaroline fosamil), and the clinical development assets aztreonam-avibactam (ATM-AVI) and CXL. (businesswire.com)
- DUBLIN, Ireland , March 01, 2022 (GLOBE NEWSWIRE) -- Nabriva Therapeutics plc (NASDAQ: NBRV), a biopharmaceutical company engaged in the commercialization and development of innovative anti-infective agents to treat serious infections, today announced that it has granted a non-statutory stock option to purchase an aggregate of 12,000 ordinary shares of Nabriva Therapeutics as an inducement to a newly hired employee. (nabriva.com)
- Nabriva Therapeutics is a biopharmaceutical company engaged in the commercialization and development of innovative anti-infective agents to treat serious infections. (nabriva.com)
Organisms2
- It is used as a single agent and interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms. (medscape.com)
- A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. (fpnotebook.com)
Symptoms4
- Residents with a clinical presentation of severe sepsis (i.e., hemodynamic instability, acute onset of confusion) without localizing genitourinary signs or symptoms are unlikely to have a urinary source, unless underlying urologic abnormalities are present. (infectiousdiseaseadvisor.com)
- Anti-allergy medications are commonly used for preventing and relieving allergy symptoms. (jagsonpal.com)
- Include it in 1999/10 and published in their liver a form of deafness in primary care, the only factors that increase the hormonal synthesis (class i) reduce the mobility and urinary symptoms in which elements have continuously graded truth values (true or false) of its mechanism of action may be asked questions like if a more detailed questions. (dnaconnexions.com)
- Lower urinary tract symptoms and benign prostatic hyperplasia : from research to bedside / Giuseppe Morgia, Giorgio Ivan Russo. (pitt.edu)
Biofilms1
- Development of Phage Cocktails to Treat E. coli Catheter-Associated Urinary Tract Infection and Associated Biofilms. (viictr.org)
Urine1
- Prostate hypertrophy in men results in urinary retention and turbulent urethral urine flow, facilitating urinary infection. (infectiousdiseaseadvisor.com)
Respiratory tract1
- Learn how Baytril® (enrofloxacin) can help treat dermal, urinary and respiratory tract infections in dogs. (elancodvm.com)
Prophylaxis1
- This multicenter, randomized, double-blind, placebo-controlled trial was designed to determine whether daily antimicrobial prophylaxis is superior to placebo in preventing recurrence of urinary tract infection (UTI) in children with vesicoureteral reflux (VUR). (clinicaltrials.gov)
Drug Discovery2
- Recent Advances in Anti-Infective Drug Discovery publishes review and research articles, drug clinical trial studies and guest edited thematic issues on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. (benthamscience.com)
- The journal also covers recent research in fast emerging therapeutic areas/targets & therapeutic agents related to anti-infective drug discovery. (benthamscience.com)
Bone1
- Agents that destroy bone marrow activity. (nih.gov)
Therapeutic areas1
- As we continue to reshape our Essential Health portfolio, we are focusing on areas that further address global public health needs and that complement our core capabilities and experience in therapeutic areas, including anti-infectives. (businesswire.com)
Medicines2
- We are committed to looking for ways to enhance our portfolio around the world where we offer patients and healthcare professionals access to more than 60 anti-infective and anti-fungal medicines. (businesswire.com)
- The addition of AstraZeneca's complementary small molecule anti-infectives portfolio will help expand patient access to these important medicines and enhance our global expertise and offerings in this increasingly important area of therapeutics, in addition to providing the opportunity for near-term revenue growth," said John Young, group president, Pfizer Essential Health. (businesswire.com)