A name originally applied to a group of skin diseases characterized by the formation of fine, branny scales, but now used only with a modifier. (Dorland, 27th ed)

Bioterrorism alleging use of anthrax and interim guidelines for management--United States, 1998. (1/6962)

From October 30 through December 23, 1998, CDC received reports of a series of bioterroristic threats of anthrax exposure. Letters alleged to contain anthrax were sent to health clinics on October 30, 1998, in Indiana, Kentucky, and Tennessee. During December 17-23 in California, a letter alleged to contain anthrax was sent to a private business, and three telephone threats of anthrax contamination of ventilation systems were made to private and public buildings. All threats were hoaxes and are under investigation by the Federal Bureau of Investigation (FBI) and local law enforcement officials. The public health implications of these threats were investigated to assist in developing national public health guidelines for responding to bioterrorism. This report summarizes the findings of these investigations and provides interim guidance for public health authorities on bioterrorism related to anthrax.  (+info)

Ciprofloxacin decreases the rate of ethanol elimination in humans. (2/6962)

BACKGROUND: Extrahepatic ethanol metabolism is postulated to take place via microbial oxidation in the colon, mediated by aerobic and facultative anaerobic bacteria. AIMS: To evaluate the role of microbial ethanol oxidation in the total elimination rate of ethanol in humans by reducing gut flora with ciprofloxacin. METHODS: Ethanol was administered intravenously at the beginning and end of a one week period to eight male volunteers. Between ethanol doses volunteers received 750 mg ciprofloxacin twice daily. RESULTS: A highly significant (p=0.001) reduction in the ethanol elimination rate (EER) was detected after ciprofloxacin medication. Mean (SEM) EER was 107.0 (5.3) and 96.9 (4.8) mg/kg/h before and after ciprofloxacin, respectively. Faecal Enterobacteriaceae and Enterococcus sp. were totally absent after medication, and faecal acetaldehyde production capacity was significantly (p<0.05) decreased from 0.91 (0.15) to 0.39 (0.08) nmol/min/mg protein. Mean faecal alcohol dehydrogenase (ADH) activity was significantly (p<0. 05) decreased after medication, but ciprofloxacin did not inhibit human hepatic ADH activity in vitro. CONCLUSIONS: Ciprofloxacin treatment decreased the ethanol elimination rate by 9.4%, with a concomitant decrease in intestinal aerobic and facultative anaerobic bacteria, faecal ADH activity, and acetaldehyde production. As ciprofloxacin has no effect on liver blood flow, hepatic ADH activity, or cytochrome CYP2E1 activity, these effects are probably caused by the reduction in intestinal flora.  (+info)

Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (3/6962)

The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia.  (+info)

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (4/6962)

8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection.  (+info)

Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. (5/6962)

The effect of inoculum size (N0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its predictability, killing and regrowth kinetics of Staphylococcus aureus and Escherichia coli exposed to monoexponentially decreasing concentrations of trovafloxacin (as a single dose) and ciprofloxacin (two doses at a 12-h interval) were compared at N0 = 10(6) and 10(9) CFU/ml (S. aureus) and at N0 = 10(6), 10(7), and 10(9) CFU/ml (E. coli). A series of pharmacokinetic profiles of trovafloxacin and ciprofloxacin with respective half-lives of 9.2 and 4 h were simulated at different ratios of area under the concentration-time curve (AUC) to MIC (in [micrograms x hours/milliliter]/[micrograms/milliliter]): 58 to 466 with trovafloxacin and 116 to 932 with ciprofloxacin for S. aureus and 58 to 233 and 116 to 466 for E. coli, respectively. Although the effect of N0 was more pronounced for E. coli than for S. aureus, only a minor increase in minimum numbers of surviving bacteria and an almost negligible delay in their regrowth were associated with an increase of the N0 for both organisms. The N0-induced reductions of the intensity of the antimicrobial effect (IE, area between control growth and the killing-regrowth curves) were also relatively small. However, the N0 effect could not be eliminated either by simple shifting of the time-kill curves obtained at higher N0s by the difference between the higher and lowest N0 or by operating with IEs determined within the N0-adopted upper limits of bacterial numbers (IE's). By using multivariate correlation and regression analyses, linear relationships between IE and log AUC/MIC and log N0 related to the respective mean values [(log AUC/MIC)average and (log N0)average] were established for both trovafloxacin and ciprofloxacin against each of the strains (r2 = 0.97 to 0.99). The antimicrobial effect may be accurately predicted at a given AUC/MIC of trovafloxacin or ciprofloxacin and at a given N0 based on the relationship IE = a + b [(log AUC/MIC)/(log AUC/MIC)average] - c [(log N0)/(log N0)average]. Moreover, the relative impacts of AUC/MIC and N0 on IE may be evaluated. Since the c/b ratios for trovafloxacin and ciprofloxacin against E. coli were much lower (0.3 to 0.4) than that for ampicillin-sulbactam as examined previously (1.9), the inoculum effect with the quinolones may be much less pronounced than with the beta-lactams. The described approach to the analysis of the inoculum effect in in vitro dynamic models might be useful in studies with other antibiotic classes.  (+info)

In vitro activities of cephalosporins and quinolones against Escherichia coli strains isolated from diarrheic dairy calves. (6/6962)

The in vitro activities of several cephalosporins and quinolones against 195 strains of Escherichia coli isolated from diary calves affected by neonatal diarrhea were determined. One hundred thirty-seven of these strains produced one or more potential virulence factors (F5, F41, F17, cytotoxic necrotizing factor, verotoxin, and the eae gene), but the remaining 58 strains did not produce any of these factors. From 11 to 18% of the E. coli strains were resistant to cephalothin, nalidixic acid, enoxacin, and enrofloxacin. However, cefuroxime, cefotaxime, and cefquinome were highly effective against the E. coli isolates tested. Some significant differences (P < 0.05) in resistance to quinolones between the strains producing potential virulence factors and nonfimbriated, nontoxigenic, eae-negative strains were found. Thus, eae-positive, necrotoxigenic, and verotoxigenic (except for nalidixic acid) E. coli strains were significantly more sensitive to nalidixic acid, enoxacin, and enrofloxacin than nonfimbriated, nontoxigenic, eae-negative strains. Moreover, eae-positive strains were significantly more sensitive to enoxacin and enrofloxacin than F5-positive strains. Thus, the result of this study suggest that the bovine E. coli strains that produce some potential virulence factors are more sensitive to quinolones than those that do not express these factors.  (+info)

Influences of urinary pH on ciprofloxacin pharmacokinetics in humans and antimicrobial activity in vitro versus those of sparfloxacin. (7/6962)

The impact of acidification and alkalinization of urine on the pharmacokinetics of ciprofloxacin was investigated after single 200-mg oral doses were administered to nine healthy male volunteers. In addition, the effect of human urine on the MICs of ciprofloxacin and sparfloxacin against some common urinary tract pathogens such as Escherichia coli and Pseudomonas aeruginosa was investigated. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbonate, respectively. Plasma ciprofloxacin levels in all subjects were adequately described in terms of two-compartment model kinetics with first-order absorption. Acidification and alkalinization treatments had no effect on ciprofloxacin absorption, distribution, or elimination. The total amount of unchanged ciprofloxacin excreted over 24 h under acidic conditions was 88.4 +/- 14.5 mg (mean +/- standard deviation) (44.2% of the oral dose) and 82.4 +/- 16.5 mg (41.2% of the oral dose) under alkaline conditions, while the total amount of unchanged drug excreted over 24 h in volunteers receiving neither sodium bicarbonate nor ammonium chloride was 90.53 +/- 9.8 mg (45.2% of the oral dose). The mean renal clearance of ciprofloxacin was 16.78 +/- 2.67, 16.08 +/- 3.2, and 16.31 +/- 2.67 liters/h with acidification, alkalinization, and control, respectively. Renal clearance and concentrations of ciprofloxacin in urine were not correlated with urinary pH. The antibacterial activity of ciprofloxacin and sparfloxacin against E. coli NIHJ JC-2 and P. aeruginosa ATCC 27853 was affected by human urine and in particular by its pH. The activities of both quinolones against E. coli NIHJ JC-2 were lower at lower urinary pH and rather uniform, while in the case of P. aeruginosa ATCC 27853 ciprofloxacin was more active than sparfloxacin.  (+info)

Cloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IV. (8/6962)

The topoisomerase IV subunit A gene, parC homolog, has been cloned and sequenced from Pseudomonas aeruginosa PAO1, with cDNA encoding the N-terminal region of Escherichia coli parC used as a probe. The homolog and its upstream gene were presumed to be parC and parE through sequence homology with the parC and parE genes of other organisms. The deduced amino acid sequence of ParC and ParE showed 33 and 32% identity with that of the P. aeruginosa DNA gyrase subunits, GyrA and GyrB, respectively, and 69 and 75% identity with that of E. coli ParC and ParE, respectively. The putative ParC and ParE proteins were overexpressed and separately purified by use of a fusion system with a maltose-binding protein, and their enzymatic properties were examined. The reconstituted enzyme had ATP-dependent decatenation activity, which is the main catalytic activity of bacterial topoisomerase IV, and relaxing activities but had no supercoiling activity. So, the cloned genes were identified as P. aeruginosa topoisomerase IV genes. The inhibitory effects of quinolones on the activities of topoisomerase IV and DNA gyrase were compared. The 50% inhibitory concentrations of quinolones for the decatenation activity of topoisomerase IV were from five to eight times higher than those for the supercoiling activities of P. aeruginosa DNA gyrase. These results confirmed that topoisomerase IV is less sensitive to fluoroquinolones than is DNA gyrase and may be a secondary target of new quinolones in wild-type P. aeruginosa.  (+info)

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The presence anti-infectives in environmental waters is of interest because of their potential role in the dissemination of anti-infective resistance in bacteria and other harmful effects on non-target species such as algae and shellfish. Since no information on global trends regarding the contamination caused by these bioactive substances is yet available, we decided to investigate the impact of income inequality between countries on the occurrence of anti-infectives in surface waters. In order to perform such study, we gathered concentration values reported in the peer-reviewed literature between 1998 and 2014 and built a database. To fill the gap of knowledge on occurrence of anti-infectives in African countries, we also collected 61 surface water samples from Ghana, Kenya, Mozambique and South Africa, and measured concentrations of 19 anti-infectives. A mixed one-way analysis of covariance (ANCOVA) model, followed by Turkey-Kramer post hoc tests was used to identify potential differences in ...
Anti-infective Drugs Market Global Industry Analysis, Size, Share, Growth, Trends, and Forecast 2017-2025. Anti-infective Drugs Market: OverviewThis report studies the current as well as future prospects of the global anti-infective drugs market. Stakeholders of this report include companies and intermediaries engaged in the manufacture, commercial
Press Release issued Sep 1, 2017: Looking at the current trends, the market for veterinary anti-infectives is focused towards livestock and companion animals which are in direct interaction with humans. With time, veterinary anti-infectives have advanced into different drug classes so as to facilitate the sector in a better manner. To study further, a new research report has been added to the wide online collection managed by Market Research Reports Search Engine (MRRSE). The report is titled Veterinary Anti-Infectives Market: Global Industry Analysis (2012-2016) and Forecast (2017-2025), which encloses data related to the global scenario and offers actionable insights on various aspects influencing the market with the availability of statistical analysis.
Chemotherapy Chemotherapy is the treatment of a disease or condition with chemicals that have a specific effect on its cause, such as a microorganism or cancer cell. The first modern therapeutic chemical was derived from a synthetic dye.
LARK LABORATORIES (INDIA) LIMITED - Exporter, Manufacturer & Supplier of Anti-Biotics Parasiticidals & Anti-Infectives based in New Delhi, India
Following the discovery of a number of very active antibacterial compounds and the submission of patent applications (now granted), we sought a commercial partner for the development. After a substantial search led by our Research & Knowledge Exchange Services team, a licence was granted to Pharma Integra which was able to raise funds to establish a new, Scottish-based company, MGB Biopharma.. MGB Biopharma began operations in 2010. Its funded by a syndicate of some of Scotlands leading business angels, in co-operation with Scottish Enterprise. The MGB Biopharma and Strathclyde partnership is concerned with discovering and developing new anti-infective drugs, in particular antibacterial drugs based upon Strathclydes IP.. MGB Biopharma undertakes the development of clinical candidate molecules selected from the Strathclyde collection. So far, one compound, MGB-BP-3, is in clinical development for the oral treatment of Clostridium difficile infections (CDI); it has successfully completed an ...
Cempra, Inc. is a clinical-stage pharmaceutical company focused on developing differentiated anti-infectives for acute care and community settings to meet critical medical needs in the treatment of infectious diseases. Cempras two lead product candidates are currently in advanced clinical development. Solithromycin has been evaluated in two Phase 3 clinical trials for community-acquired bacterial pneumonia (CABP). Cempra is currently seeking approval for CABP for both intravenous and oral capsule formulations from the U.S. Food and Drug Administration. Solithromycin is licensed to strategic commercial partner Toyama Chemical Co., Ltd., a subsidiary of FUJIFILM Holdings Corporation, for certain exclusive rights in Japan. Cempra is contracted with BARDA for the development of solithromycin for pediatric use and has commenced enrollment in a global Phase 2/3 trial to evaluate the safety and efficacy of solithromycin versus standard of care antibiotics in children and adolescents from two months to ...
Basilea Pharmaceutica AG / Basilea reports presentation of new data on investigational anti-infectives isavuconazole, ceftobiprole and BAL30072 at ICAAC . Processed and transmitted by Thomson Reuters ONE. The issuer is solely responsible for the content of this announcement. Basel, Switzerland, September 11, 2012 - Basilea Pharmaceutica Ltd
Compare ophthalmic steroids with anti-infectives. View important safety information, ratings, user reviews, popularity and more...
Gram-negative bacteria possess a unique and complex cell envelope, composed of an inner and outer membrane separated by an intermediate cell wall-containing periplasm. This tripartite structure acts intrinsically as a significant biological barrier, often limiting the permeation of anti-infectives, and so preventing such drugs from reaching their target. Furthermore, identification of the specific permeation-limiting envelope component proves difficult in the case of many anti-infectives, due to the challenges associated with isolation of individual cell envelope structures in bacterial culture. The development of an in vitro permeation model of the Gram-negative inner membrane, prepared by repeated coating of physiologically-relevant phospholipids on Transwell®filter inserts, is therefore reported, as a first step in the development of an overall cell envelope model. Characterization and permeability investigations of model compounds as well as anti-infectives confirmed the suitability of the ...
Anti-Infective Agents is an essential journal for all infectious disease researchers in industry, academia and the health services.
Anti-Infective Agents is an essential journal for all infectious disease researchers in industry, academia and the health services....
SAN FRANCISCO, August 1, 2016 /PRNewswire/ -- Anti-Infective Agents Market Worth $111.4 Billion By 2024: Grand View Research, Inc.
Anti-infective agents are drugs utilized to exert effect on invading foreign organisms on the body, especially those which can cause infection.
Ceragenix Pharmaceuticals, Inc. is a biopharmaceutical company headquartered in Denver, Colorado that develops prescription therapies based on a platform of proprietary surface active technologies-skin Barrier Repair Technology (BRT) and Cerageninis, a new class of broad spectrum anti-infectives. The company discovers, develops and commercializes anti-infective drugs based on its proprietary class of compounds, Ceragenins. Active against a range of gram positive and gram negative bacteria, these agents are being developed as anti-infective medical device coatings and as therapeutics for antibiotic-resistant organisms. Ceragenix developed EpiCeram. It is a topical non-steroidal skin care cream based on the research of Peter Elias for the treatment of atopic dermatitis (eczema). Ceragenixs second platform technology addresses multidrug resistant bacterial and viral infections. The anti-infective technology is based on the research of Dr. Paul B. Savage, Professor and Associate Chair of ...
Note: This eBook sample comprises of the Cover Page, Title Page, End User License Agreement, Foreword, Preface, Table of Contents, Editors Biography and the first three pages of each chapter. These sample images are in low resolution to optimise the file size and are only to provide an overview about the scope of the eBook and highlight the layout and presentation. These images are only for website preview and not for any other use ...
TY - JOUR. T1 - Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents. AU - Conlon, JM. AU - Mechkarska, M. AU - Lukic, ML. AU - Flatt, Peter. PY - 2014/5/2. Y1 - 2014/5/2. N2 - Frog skin constitutes a rich source of peptides with a wide range of biological properties. These include host-defense peptides with cytotoxic activities against bacteria, fungi, protozoa, viruses, and mammalian cells. Several hundred such peptides from diverse species have been described. Although attention has been focused mainly on antimicrobial activity, the therapeutic potential of frog skin peptides as anti-infective agents remains to be realized and no compound based upon their structures has yet been adopted in clinical practice. Consequently, alternative applications are being explored. Certain naturally occurring frog skin peptides, and analogs with improved therapeutic properties, show selective ...
Basel, Switzerland, March 6, 2009 - Basilea s novel antibiotic BAL30072 demonstrates unrivalled activity against some of the most difficult to treat multi-resis
The combination of multiple therapeutic modalities with synergetic effects is a promising approach to enhance antibacterial efficiency and possibly decrease the needed concentration of bactericidal reagents. In new work, scientists report a path to achieve efficient localized bacterial eradication and anti-infective therapy by combining the advantages of 2D graphene and metal organic framework (MOF)-derived carbon nanomaterials. This proposed MOF-derived 2D carbon nanosheets (2D-CNs) can form aggregations spontaneously under NIR irradiation and meanwhile exhibit localized triple bactericidal modalities.
/PRNewswire/ -- Europe and Asia Pacific are growing regions in this market, but North America is the most lucrative among the other regions. This can be...
Beximco Pharmaceuticals Ltd (BPL) is a leading manufacturer of pharmaceutical formulations and Active Pharmaceutical Ingredients (APIs) in Bangladesh. BPL is the largest exporter of generic drugs in the country and its state-of-the-art manufacturing facilities are already certified by major global regulatory authorities like TGA, GCC and ANVISA, while awaiting audits and approvals by US FDA and UKMHRA.
Beximco Pharmaceuticals Ltd (BPL) is a leading manufacturer of pharmaceutical formulations and Active Pharmaceutical Ingredients (APIs) in Bangladesh. BPL is the largest exporter of generic drugs in the country and its state-of-the-art manufacturing facilities are already certified by major global regulatory authorities like TGA, GCC and ANVISA, while awaiting audits and approvals by US FDA and UKMHRA.
In the treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above ...
Switzer Lifescience Pvt. Ltd. is to provide value through pioneering work, research & development and quality pharmaceuticals across the globe.
NSMEDS.COM offers antiinfectives prescription drugs online with no script needed. Buy cheap generic antiinfectives drugs and save up to 90%. Free shipping worldwide available.
Free Online Library: Ruthigen Announces First Patient Enrollment in the Phase 1/2 Human Clinical Trial of RUT58-60, a Broad-Spectrum Anti-Infective Drug Candidate Designed for Prophylactic Use During Invasive Surgery. by PR Newswire; Business News, opinion and commentary Antibiotics Product development Clinical trials
The present invention relates to bi-substrate inhibitor molecules combining (i) a pyridine, pyridinium or dihydropyridine-type structure allied to active metabolites of isoniazide, or related structures, and (ii) a hydrophobic substituent. The invention also relates to the method for preparing said molecules, to the pharmaceutical compositions containing said molecules, and to the use thereof as inhibitors of enoyl reductase for the preparation of a drug, especially an anti-infective drug for the treatment of tuberculosis.
Mepron is intended for people with have Pneumocystis jiroveci (formerly P. carinii) pneumonia (PCP), who do not tolerate the other drugs for PCP. It w
US patent # 6410059): Cow Urine is scientifically proven to enhance the anti-microbial effects of antibiotic and antifungal agents. The invention relates to a novel use of Cow Urine as activity enhancer and availability facilitator for bioactive molecules, including anti-infective agents. The invention has direct implication in drastically reducing the dosage of antibiotics, drugs and anti-infective agent while increasing the efficiency of absorption of bio-active molecules, thereby reducing the cost of treatment and also the side-effects due to toxicity ...
This is a competitive renewal of our grant application 5R01AI055475-09 (titled Synthesis of Antibiotics). We are expanding the scope of our investigations to in...
Kruse W, Eggert-Kruse W, Rampmaier J, et al. Dosage frequency and drug-compliance behavior - a comparative study on compliance with a medication to be taken twice or four times daily. Eur J Clin Pharmacol 1991; 41: 589-92PubMedCrossRefGoogle Scholar ...
Reactions to Furoxone have been reported including a fall in blood pressure, urticaria, fever, arthralgia, and a vesicular morbilliform rash. Other adverse effects can include a brown discoloration of the urine; hemolysis can occur in G6PDH-deficient patients. The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors ...
Reactions to Furoxone have been reported including a fall in blood pressure, urticaria, fever, arthralgia, and a vesicular morbilliform rash. Other adverse effects can include a brown discoloration of the urine; hemolysis can occur in G6PDH-deficient patients. The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors ...
Before taking Daraprim, it is important for your doctor to know about any allergies or other medical conditions you have to ensure Daraprims safety a
Anti-infective drugs have been one of the most effective health interventions in the history of modern medicine, but evolving resistance to these drugs among many infectious agents, especially bacteria, is a threat to humanity, says the second statement. It highlights two threats in particular: the steady rise worldwide of untreatable tuberculosis infections, and Enterobacteria, a common bacterial infection spread in hospital settings that has recently become resistant to last-resort antibiotics. The statement includes six recommendations to combat drug resistance through better global surveillance, more responsible use of anti-infective drugs, enhanced prevention of infection, and the discovery of new drugs. Developing countries need to be full partners in this effort because drug resistance more acutely affects them, the statement adds ...
Birex SE® is a surface cleaner and disinfectant. As a broad spectrum antimicrobial, it is effective againstMycobacterium TB (10 minutes), HIV-1 (1 minute), staphylococcus, salmonella, pseudomonas, streptococcus, drug resistant organisms like MRSA, and H1N1 (swine flu). Birex SE complies with OSHAs Bloodborne Pathogens Standard and meets 2003 CDC guidelines for hospital disinfectants (intermediate level ...
Free Online Library: Antimicrobial use and antimicrobial resistance: a population perspective. (Perspectives). by Emerging Infectious Diseases; Health, general Anti-infective agents Physiological aspects Antibiotics Drug resistance in microorganisms Microbial drug resistance
What is Bimoxyl LA? Bimoxyl LA is a is a broad spectrum antimicrobial injection, containing 150mg/ml amoxicillin (as amoxicillin trihydrate Ph.Eur.) B...
|p|These findings suggest that 82.4% of aerobic surgical isolates were susceptible to a concentration of garenoxacin | or = 1.0 mg/L, whereas 84.5% of the anaerobic isolates were susceptible to a garenoxacin concentration | or = 1.0 mg/L. Garenoxacin may be a valuable surgical anti-infective for|/p| …
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Infectious diseases are becoming a major menace to the state of health worldwide, with difficulties in effective treatment especially of nosocomial infections caused by Gram-negative bacteria being increasingly reported. Inadequate permeation of anti-infectives into or across the Gram-negative bacterial cell envelope, due to its intrinsic barrier function as well as barrier enhancement mediated by resistance mechanisms, can be identified as one of the major reasons for insufficient therapeutic effects. Several in vitro, in silico, and in cellulo models are currently employed to increase the knowledge of anti-infective transport processes into or across the bacterial cell envelope; however, all such models exhibit drawbacks or have limitations with respect to the information they are able to provide ...
Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery ...
Start Over You searched for: Formats Text ✖Remove constraint Formats: Text Collections Medicine in the Americas, 1610-1920 ✖Remove constraint Collections: Medicine in the Americas, 1610-1920 Copyright Public domain ✖Remove constraint Copyright: Public domain Subjects Anti-Infective Agents, Local ✖Remove constraint Subjects: Anti-Infective Agents, Local Subjects Phenols ✖Remove constraint Subjects: Phenols ...
Xellia Pharmaceuticals Focuses On Innovation In Anti-infectives With Formation Of Scientific Advisory Board - read this article along with other careers information, tips and advice on BioSpace
Heerlen, NL - Royal DSM, the global Life Sciences and Materials Sciences company, announces today that it has established the 50/50 global joint venture for its business group DSM Anti-Infectives with...
Title: New Fluoroquinolones: A Class of Potent Antibiotics. VOLUME: 5 ISSUE: 11. Author(s):Marcus V. N. De Souza. Affiliation:FioCruz-Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos-Far-Manguinhos, Rua Sizenando Nabuco, 100, Manguinhos, 21041-250 - Rio de Janeiro-RJ, Brazil.. Keywords:fluoroquinolones, fluorine, microbiological activity, antibiotics. Abstract: The discovery of antibiotics opened a new era in the treatment against several pathogenic microorganisms that can disable or kill humans. The appearance of the fluoroquinolones (based on nalidixic acid, 4-quinolone-3-carboxylates), in the early 1980s, gave a new impetus in the treatment of infectious diseases. Despite these favourable properties, the earlier fluoroquinolones had limited potency against some clinically important organisms, especially Gram-positive pathogens so that the development of resistance to these organisms has become a serious problem. Thus the development of new fluoroquinolones with a better ...
0182] This is the first report of a cationic nanosuspension which exerts excellent broad spectrum antimicrobial effect, as well as good in vitro biocompatibility and superior selectivity, and easy retrievability and reusability. Other antimicrobial nanosuspensions have been based on leachable active materials such as Ag. The MBC and selectivity values of the GO-QC nanohybrid are higher than other reported values for cationic nanoparticles. The nanosuspension disclosed herein is broad spectrum antimicrobial, non-contaminating and biocompatible. The GO-QC nanohybrid has better. MBC and selectivity values compared with the individual components (GO or QC alone) which probably results from the high areal charge density. The latter and the insoluble form of the nanohybrid result in the superior reusability of the nanohybrid, which have hitherto not been demonstrated or observed with solution forms of cationic polymers. Further, this suspension also demonstrates the electrostatic-based membrane ...
It is estimated that by 2050, 10 million deaths may occur every year due to treatment resistant pathogens. Our focused team of infectious diseases physicians, operations and commercial experts are ready to help you develop the important anti-infective agents that will solve this public health crisis.
TY - JOUR. T1 - In vitro antimicrobial activity of sparfloxacin and its therapeutic efficacy on respiratory infections. AU - Watanabe, Akira. AU - Aonuma, Seiichi. AU - Kitamura, Naoto. AU - Shoji, Satoru. AU - Kikuchi, Hiroaki. AU - Tokue, Yutaka. AU - Honda, Yoshihiro. AU - Motomiya, Masakichi. PY - 1991/1/1. Y1 - 1991/1/1. N2 - The in vitro antimicrobial activity of sparfloxacin, a new quinolone agent for oral use, was measured and its therapeutic efficacy on respiratory infections was evaluated. The minimum inhibitory concentrations (MICs) of sparfloxacin (SPFX), ofloxacin (OFLX) and ciprofloxacin (CPFX) against 20 strains each of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens and Pseudomonas aeruginosa were determined by a micro-broth dilution method using the Dynatech MIC 2000 system. As shown by MICs, sparfloxacin was the most active of the 3 agents tested against Staphylococcus aureus, Escherichia coli and Enterobacter cloacae. ...
TY - JOUR. T1 - Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations in quinolone-resistant Escherichia coli isolated from humans and swine in Denmark. AU - Cavaco, Lina. AU - Frimodt-Møller, Niels. AU - Hasman, Henrik. AU - Guardabassi, Luca. AU - Nielsen, Lene. AU - Aarestrup, Frank Møller. PY - 2008. Y1 - 2008. N2 - Prevalence of quinolone resistance mechanisms and associations to minimum inhibitory concentrations (MICs) of nalidixic acid (NAL) and ciprofloxacin (CIP) were investigated in 124 Escherichia coli isolated from humans (n = 85) and swine (n = 39) in Denmark. The collection included 59 high-level CIP-resistant isolates (MIC ,= 4) from human (n = 51) and pig origin (n = 8) and 65 low-level CIP-resistant isolates (MIC ,= 0.125) from human (n = 34) and pig origin (n = 31). Resistance by target modification was screened by PCR amplification and sequencing, of the quinolone resistance determining regions (QRDRs) of gyrA, gyrB, parC, and ...
cin (E. Gotuzzo et al. personal communication) or cipro- floxacin ,,5] no more effective than the subcutaneous Looking for online definition of Ketalar in Sparfloxacin provides an alternative to ciprofloxacin for patients with acute Ciprofloxacin, a fluoroquinolone, is an extremely broad spectrum antimicrobial of foreign origin. TableResistance to clprofloxacln in 40 clinical Isolates of Escherlchla call The side effects, order cipro online no prescription to my knowledge, have been Influence of Verapamil, a known P-gp inhibitor on ciprofloxacin Includes 1947 patient rankings on scale of 1-5, comments, side effects, dosage, sex, age, time taken. Page 1 Source : santecheznous.comdruggetdrugCipro. Within the next month, the liver function test results decreased to near normal and the patient was asymptomatic. using ciprofloxacin for the prevention of spontaneous Prozac better than ole antibiotic, generic name for ciprobay cipro alternative Psychologists still debate about how, purchase cipro and ...
A series of new 4-thiazolidinone derivatives was synthesized, characterized by spectral techniques, and screened for antimicrobial activity. All the compounds were evaluated against five Gram-positive bacteria, two Gram-negative bacteria, and two fungi, at concentrations of 50, 100, 200, 400, 800, and 1600 |i|µ|/i|g/mL, respectively. Minimum inhibitory concentrations of all the compounds were also determined and were found to be in the range of 100–400 |i|µ|/i|g/mL. All the compounds showed moderate-to-good antimicrobial activity. Compounds|b| 4a|/b| [2-(4-fluoro-phenyl)-3-(4-methyl-5,6,7,8-tetrahydro-quinazolin-2-yl)-thiazolidin-4-one] and|b| 4e|/b| [3-(4,6-dimethyl-pyrimidin-2-yl)-2-(2-methoxy-phenyl)-thiazolidin-4-one] were the most potent compounds of the series, exhibiting marked antimicrobial activity against|i| Pseudomonas fluorescens|/i|,|i| Staphylococcus aureus,|/i| and the fungal strains. Thus, on the basis of results obtained, it may be concluded that
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The incidence of invasive fungal infection is increasing worldwide, and pulmonary infections in particular have become a major clinical challenge and threat to patients at risk. Most fungal pathogens causing pulmonary infections in humans are ubiquitous in the environment and inhalation is the most common route of acquisition, although pulmonary involvement in disseminated infections originating from other foci may occur. This chapter provides an overview on current diagnostic approaches and therapeutic strategies for the most common pulmonary fungal infections. Effective host defence against pulmonary fungal infections strongly depends on an efficient interaction between different parts of the innate and acquired immunity. Therefore, patients with innate and/or acquired/drug-induced impairment of the immune system and critically ill patients are at highest risk. Furthermore, genetic variations and polymorphisms of genes encoding for different constituents of the immune system seem to increase ...
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Active, clinically significant viral, bacterial, or fungal infection, or any major episode of infection requiring hospitalization or treatment with parenteral anti-infectives within 4 weeks of Screening, or completion of oral anti-infectives within 2 weeks before or during Screening, or a history of recurrent infections (ie, 3 or more of the same type of infection in a 12-month rolling period). Vaginal candidiasis, onychomycosis, and genital or oral herpes simplex virus considered by the Investigator to be sufficiently controlled would not be exclusionary ...
Heerlen, NL, Royal DSM N.V., the global Life Sciences and Materials Sciences company headquartered in the Netherlands, North China Pharmaceutical Group Corporation Ltd. (NCPC GroupCo) of Shijiazhuang,...
In the past 15-20 years, advances in antibody engineering have facilitated the generation and isolation of monoclonal antibodies (mAbs) to a wide array of antigens. Consequently, mAbs have become essential therapeutic tools and currently dominate the global protein therapeutics market. The engineering of anti-infective antibodies, however, has proven quite a challenge, despite the fact that antibodies were naturally evolved to fight infections. The identification of suitable antigens, the mode of administration and the high cost associated with the production of antibody therapeutics are some of the major hurdles for the progress of anti-infective antibodies. This dissertation addresses issues concerning the development of anti-infective antibodies against two different pathogens: SARS coronavirus (CoV) and two pathogenic species of Burkholderia bacteria. To investigate the role of affinity in viral neutralization and evolution of escape mutants, we first sought to isolate an antibody with high ...
Our systematic review about the safety of ciprofloxacin is the first review that has pooled together all reported suspected AEs due to ciprofloxacin use in paediatric patients. Ciprofloxacin is contraindicated in paediatrics because juvenile animals developed arthropathy after use.4 However, our review has identified over 16 000 children who have received ciprofloxacin. It is likely that the number of children who have received ciprofloxacin in practice is significantly greater than this.. Our review confirms that musculoskeletal toxicity is the most frequently reported AE following the use of ciprofloxacin. There is, however, a wide range of toxicity that has been reported and it is important to recognise that, like all anti-infective agents, ciprofloxacin can be associated with a broad spectrum of AEs. The toxicity profile in table 2 is pooled safety data of reported suspected AEs by individual authors; however, these AEs may not be adverse drug reactions in all cases. From our review, there ...
In case you are not aware, bacterial infections have been the cause of many deaths since time immemorial. The truth is, it is really hard to even comprehend just how many millions of people have died just because of infections from these microscopic organisms. Fortunately for us as we live in age where we have highly effective antibiotic drugs that can helps us fight off bacterial infections. One of the most highly recommended and trusted antibiotic is ciprofloxacin. If you buy ciprofloxacin, you are sure to effectively purge the infection out of your system. Of course, if you buy ciprofloxacin, make sure that you also strictly follow the directions given to you by your doctor so you can effectively treat the condition or disease caused by the bacteria.. If you will buy ciprofloxacin, you are basically buying a drug that is an anti-infective agent. Ciprofloxacin is under the class of antibiotics called fluoroquinolone and is an ideal treatment for infections that are of bacterial in origin. Your ...
Find more about the effect of several anti-infection agents against Exophiala dermatitidis and its ability to form biofilms in CF patients and others.
Amoxicillin D4 (Amoxycillin D4) is a deuterium labeled Amoxicillin. Amoxicillin is an antibiotic with good oral absorption and broad spectrum antimicrobial activity. - Mechanism of Action & Protocol.
Baytril® 100 is a sterile, ready-to-use injectable antimicrobial solution that contains enrofloxacin, a broad-spectrum fluoroquinolone antimicrobial agent.
Electrochemically activated solutions (ECAS) are generated by electrolysis of NaCl solutions, and demonstrate broad spectrum antimicrobial activity and high environmental compatibility. The biocidal efficacy of ECAS at the point of production is widely reported in the literature, as are its credentials as a
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Introduction. In low and middle income countries diagnostic, financial and infrastructural constraints mean the risk of emerging antimicrobial resistance is high. This can lead to excessive or inappropriate use of anti-infectives, and so the implementation of appropriate policies to regulate their use and curb the emergence of resistant microbial threats is consequently more important now than ever. As recognised in the Goal 3 of the WHOs Sustainable Development Goals, concerted effort is required to tackle this threat, and to highlight the challenges and developments within antimicrobial drug policies in low and middle income countries.. Aims and Scope. We are proud to present a cross-journal series to highlight the challenges and developments made within antimicrobial drug policies in low and middle income countries. We invite both reviews and original research in this collection which brings together in one place articles on this topic.. Manuscripts should be formatted according to ...
Todays post from naturalhealth365.com (see link below) returns to an old chestnut on this blog that remains relevant because of the increasing numbers of people ending up with nerve damage due to use of fluoroquinolone antibiotics. These really are antibiotics with a sting in the tail and it can be some time before the side effects appear but if you have an infection and are prescribed antibiotics by your doctor, check that they dont belong to the fluoroquinolone group (a list of common brand names appears in the article), especially if you already have, or are prone to neuropathy. There are always alternatives and you should seriously discuss these with your doctor. Further articles on the subject can be found by using the search button to the right of this blog. If in doubt, remember that the American FDA doesnt issue warnings aboiut drugs lightly - they certainly warn you about fluoroquinolones! ...
Studies on Some Plant Extracts for Their Antimicrobial Potential against Certain Pathogenic Microorganisms. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
TY - JOUR. T1 - Declining susceptibilities of gram-negative bacteria to the fluoroquinolones. T2 - Effects on pharmacokinetics, pharmacodynamics, and clinical outcomes. AU - Labreche, Matthew J.. AU - Frei, Chris. PY - 2012/11/1. Y1 - 2012/11/1. N2 - Purpose. Published evidence of rising gram-negative bacterial resistance to fluoroquinolone therapy is reviewed, with a focus on the potential need for revising pharmacokinetic-pharmacodynamic (PK-PD) targets in order to maintain acceptable clinical outcomes. Summary. With a more than threefold increase in fluoroquinolone use among U.S. adults since the introduction of second- and third-generation (i.e., respiratory) fluoroquinolones 15 years ago, surveillance data indicate a decline in some gram-negative organisms susceptibility to this antimicrobial class. These trends have raised concerns that the need to attain higher organism-specific minimum inhibitory concentrations (MICs) may lead to worse patient outcomes, even when MIC values are below ...
When we think of food as medicine, right at the top of this list should be the health building power of fermented foods. Our gastrointestinal microbiome thrives with the support of friendly, health-promoting bacteria that only properly cultured fermented foods and property selected and manufactured probiotics supplements can provide. (See more). Yolanda Sanz et al. (2010) in Probiotics as Drugs Against Human Gastrointestinal Pathogens in Frontiers in Anti-infective Drug Discovery, 1, 107-123, focus on the healthy immune stimulating function that good bacteria can provide.. Sanz et al. nicely summarize the possible mechanisms, the action of probiotics against gastrointestinal pathogens. These categories include (1) modification of the environmental conditions, (2) competition for nutrients and adhesion sites, (3) production of antimicrobial compounds, (4) modulation of the immune and non-immune defense mechanisms of the host, and (5) regulation of the intestinal neuromuscular function.. But ...
Indian drug maker Ranbaxy Laboratories Ltd. has a launched a generic version of the anti-infective drug clarithromycin in the U.K. after winning a patent infringement lawsuit brought by U.S.-based Abbott Laboratories.
Read the findings of drug resistance and drug surveillance studies in our antimicrobial studies publications. You can look through years of research.
San Francisco Bay Area based LiveLeaf is pioneering health solutions that harness the biochemical foundations of plant immunity to balance microbiome interactions with our immune systems the way nature intended. Our patented technology transforms abundant polyphenols found in many sustainably-cultivated food plants into ingredients with unprecedented immunologic potency. Our lead LiveXtract® has been safety-proven and performance-validated in commercial human and animal supplement products. It is now being developed into novel anti-infective drugs free of side effects and bacterial resistance concerns that limit the future of todays antibiotics.. ...
(2017) Dar et al. Adv. Biomed. Pharma. The purpose of this work was to evaluate the antimicrobial potential of endophytic fungi isolated from different high value medicinal plants of Kashmir valley. Evaluation of some endophytes has bee...
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A JAMA Network Open study details the costs incurred after price increases in anti-infective drugs, while a JGIM study analyzes state legislative action on....
[07-26-2016] The U.S. Food and Drug Administration (FDA) approved changes to the labels of fluoroquinolone antibacterial drugs for systemic use (i.e., taken by mouth or by injection).
Methenamine: An anti-infective agent most commonly used in the treatment of urinary tract infections. Its anti-infective action derives from the slow release of formaldehyde by hydrolysis at acidic pH. (From Martindale, The Extra Pharmacopoeia, 30th ed, p173)
Ciprofloxacin Assay. Ciprofloxacin is an antibiotic that binds DNA topoisomerases and blocks the DNA replication process in. bacteria. The MicroGram Ciprofloxacin Assay Kit is designed for measurement of low micrograms of. ciprofloxacin. The assay is based on increase of fluorescence at 470 nm of the assay reagent in the. presence of ciprofloxacin. The assay kit can be used for measurement of ciprofloxacin concentrations in. drug discovery, drug development and pharmaceutical samples. The assay is not compatible with biological. samples containing amino acids or other molecules or buffers with amines.. ...
Discuss the indications for use of the major classes of anti-infectives, including the penicillins, cephalosporins, tetracyclines, aminoglycosides, macrolides, antifungals, sulfonamides, vancomycin, antiviral agents, antituberculars, chloramphenicol, clindamycin, metronidazole, and monoclonal antibodies ...
Orbifloxacin is a fluoroquinolone with broad-spectrum antimicrobial activity, and belongs to the third generation of quinolones. Regarding the quality control of medicines, a validated microbiological assay for determination of orbifloxacin in pharmaceutical formulations has not as yet been reported. For this purpose, this paper reports the development and validation of a simple, sensitive, accurate and reproducible agar diffusion method to quantify orbifloxacin in tablet formulations. The assay is based on the inhibitory effect of orbifloxacin upon the strain of Staphylococcus aureus ATCC 25923 used as test microorganism. The results were treated statistically by analysis of variance and were found to be linear (r = 0.9992) in the selected range of 16.0-64.0 μg/mL, precise with relative standard deviation (RSD) of repeatability intraday = 2.88%, intermediate precision RSD = 3.33%, and accurate (100.31%). The results demonstrated the validity of the proposed bioassay, which allows reliable orbifloxacin
The discovery of penicillin by Fleming in 1928 led to the development of antibiotics and represents one of the remarkable achievements in the field of pharmaceutics. Antibiotics allow a potent treatment in the fight against severe infectious diseases such as endocarditis or pneumonia. As a result of their administration, it was possible that, according to the German Federal Statistical Office, the bacterial infections as cause of death in 2012 were far behind cancer and cardiovascular disease. Due to rare new approval of antibiotics and especially the increase in the resistance of bacteria responsible usage of existing antibiotics is becoming increasingly important. Therefore optimised dosing guidelines in the form of patient subgroup-adapted dosage regimens represent a time- and cost-saving method for the use of anti-infectives. In our Dept., the establishment of dosing regimens is based on the pharmacokinetic (PK) and pharmacodynamic (PD) relationships. The basis of the PK/PD models primarily ...
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The flow rate is about 1.5 mL per minute. Chromatograph the Resolution solution, and record the peak responses as directed for Procedure: the retention time for ciprofloxacin is between 6.4 and 10.8 minutes; the relative retention times are about 0.7 for ciprofloxacin ethylenediamine analog and 1.0 for ciprofloxacin; and the resolution, R, between the ciprofloxacin ethylenediamine analog peak and the ciprofloxacin peak is not less than 6. Chromatograph the Standard preparation, and record the peak responses as directed for Procedure: the column efficiency, determined from the ciprofloxacin peak, is not less than 2500 theoretical plates; the tailing factor for the ciprofloxacin peak is not more than 2.0; and the relative standard deviation for replicate injections is not more than 1.5 ...
Anti-Infective Agents. 18 (3): 233-238. doi:10.2174/2211352517666190531110829. S2CID 191139942. "What Is E. Coli?". WebMD. ...
Antifungals, Anti-infective agents, British inventions). ... a new antifungal agent from the novel orotomide class". www.asm ... Oliver, J.; Law, D.; Sibley, G.; Kennedy, A.; Birch, M. "F901318, a Novel Antifungal Agent from the Orotomide Class: Discovery ... The discovery was formally announced at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) 55th ... April 2018). "Pharmacodynamics of the Novel Antifungal Agent F901318 for Acute Sinopulmonary Aspergillosis Caused by ...
Current Perspectives on Anti-Infective Agents. Bentham Science Publishers. pp. 229-230. ISBN 978-981-14-3272-9. The Medical ... Tiekink, Edward R.T.; Gielen, Marcel (2005). Metallotherapeutic Drugs and Metal-based Diagnostic Agents : The Use of Metals in ...
Anti-Infective Agents in Medicinal Chemistry. 6 (1): 49-56. doi:10.2174/187152107779314179. Archived from the original (PDF) on ... Anti-Infective Agents in Medicinal Chemistry. 6 (1): 49-56. doi:10.2174/187152107779314179. Archived (PDF) from the original on ... The earlier-generation agents are, in general, more narrow-spectrum than the later ones, but no standard is employed to ... It has been recommended that fluoroquinolones not be used as a first-line agent for community-acquired pneumonia, instead ...
Anti-Infective Agents in Medicinal Chemistry. 6 (2): 133-144. doi:10.2174/187152107780361670. ISSN 1871-5214. Pubchem. " ... Anti-Infective Agents in Medicinal Chemistry. 6 (2): 133-144. doi:10.2174/187152107780361670. Retrieved 2018-10-07. " ... Greenwood, D.; Irving, W.L. (2012-01-01). Antimicrobial agents. Medical Microbiology. pp. 54-68. doi:10.1016/B978-0-7020-4089- ... Synthesis and structure of clindamycin, a potent antibacterial agent". Journal of Medicinal Chemistry. 13 (4): 616-619. doi: ...
Anti-Infective Agents in Medicinal Chemistry. 8 (4): 345-366. doi:10.2174/187152109789760199. ISSN 1871-5214. CREEK, DARREN J ... Antiprotozoal agents, Biocides, All stub articles, Antiinfective agent stubs). ... As a result, agents effective against one pathogen may not be effective against another. Antiprotozoal agents can be grouped by ... Antiprotozoal agents (ATC code: ATC P01) is a class of pharmaceuticals used in treatment of protozoan infection. A paraphyletic ...
Lee, V. J. (2007-01-01), Taylor, John B.; Triggle, David J. (eds.), "7.22 - Anti-Gram Positive Agents of Natural Product ... Expert Review of Anti-Infective Therapy. 4 (6): 939-45. doi:10.1586/14787210.4.6.939. PMID 17181409. S2CID 12881565. Scheinfeld ... Fulco P, Wenzel RP (December 2006). "Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent". ...
"Minor groove binders as anti-infective agents". Pharmacology & Therapeutics. 139 (1): 12-23. doi:10.1016/j.pharmthera.2013.03. ... Derivates from distamycin are used as alkylating antineoplastic agents to combat tumours. Derivates with fluorophores are used ... "Hybrid molecules between distamycin a and active moieties of antitumor agents". Bioorganic & Medicinal Chemistry. 15 (1): 17-35 ...
"Progress Towards Host-Directed Anti-Infective Agents , Department of Chemistry , Columbian College of Arts & Sciences , The ... His research looks to develop antibacterial agents and technologies for bioenergy. In 2020, he was named by Cell Press as one ... At MIT, he worked with Robert T. Sauer on antibacterial agents that can impede protein turnover in bacteria. Sello has ...
... combining nanoparticles with antibiotics and other antimicrobial agents". Expert Review of Anti-Infective Therapy. 9 (11): 1035 ...
Expert Review of Anti-Infective Therapy. 6, 685-711 (2008). Park CH, Robicsek A, Jacoby GA, Sahm D, Hooper DC. Prevalence in ... Antimicrobial Agents and Chemotherapy. 40, 2080-2086 (1996). Yun-Song Y, Xiao-Xing D, Zhi-Hui Z, Ya-Gang C, Lan-Juan L. First ... Antimicrobial Agents and Chemotherapy. 47, 559-562 (2003). Park YJ, Yu JK, Lee S, Oh EJ, Woo GJ. Prevalence and diversity of ... Infectious Agents and Disease. 2 (4), 272-274 (1993). Zogaj X, Bokranz W, Nimtz M, Romling U. Production of cellulose and curli ...
Wuthiekanun V, Peacock SJ (June 2006). "Management of melioidosis". Expert Review of Anti-infective Therapy. 4 (3): 445-55. doi ... Agents Chemother. 54 (8): 3113-20. doi:10.1128/AAC.01803-09. PMC 2916348. PMID 20498323. Norris MH, Kang Y, Lu D, Wilcox BA, ... B. pseudomallei is intrinsically resistant to many antimicrobial agents by virtue of its efflux pump mechanism. This mediates ... Rose, L. J.; O'Connell, H. (2009-05-01). "UV Light Inactivation of Bacterial Biothreat Agents". Applied and Environmental ...
... an antifungal agent for the topical treatment of superficial candidiasis". Expert Review of Anti-Infective Therapy. 11 (4): 347 ... Amphotericin B has been replaced by safer agents in most circumstances, but is still used, despite its side effects, for life- ... The "azole" class of antifungal agents inhibit the enzyme that performs these demethylation steps in the biosynthetic pathway ...
O'Keeffe J, Doyle S, Kavanagh K (December 2003). "Exposure of the yeast Candida albicans to the anti-neoplastic agent ... den Boer M, Davidson RN (April 2006). "Treatment options for visceral leishmaniasis". Expert Review of Anti-Infective Therapy. ... Neuromuscular-blocking agents: Amphorectin B-induced hypokalemia may potentiate the effects of certain paralytic agents. ... This is amphotericin B's primary effect as an antifungal agent. It has been found that the amphotericin B/ergosterol ...
"Most-recognized brands: Anti-infectives, December 2013". Drugs.com. Geddes AM, Klugman KP, Rolinson GN (December 2007). " ... Alice Yan; Toh Han Shih (16 July 2013). "Shanghai travel agent's revenue surge led to arrests in GSK bribery case". South China ... "FDA Adds Boxed Warning for Heart-related Risks to Anti-Diabetes Drug Avandia. Agency says drug to remain on market, while ... The drugs involved were Kytril, an antiemetic; Bactroban, used to treat skin infections; Paxil, the anti-depressant; and ...
Panipenem/betamipron Finch RG (2003). Antibiotic and chemotherapy: anti-infective agents and their use in therapy. Elsevier ...
When infection attacks the body, anti-infective drugs can suppress the infection. Several broad types of anti-infective drugs ... First, the catalog of infectious agents has grown to the point that virtually all of the significant infectious agents of the ... Second, an infectious agent must grow within the human body to cause disease; essentially it must amplify its own nucleic acids ... Not all infectious agents cause disease in all hosts. For example, less than 5% of individuals infected with polio develop ...
v t e (Anti-infective agents, All stub articles, Antiinfective agent stubs). ... Guadinomines are anti-infective compounds produced by Streptomyces sp. K01-0509. Guadinomine B is the most potent known ...
"Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections". Nature Reviews. Microbiology. 5 (6 ...
A course of oral antibiotics or anti-infective agents will be prescribed. Additionally, a urinary analgesic such as ... An IV antibiotic or other anti-infective medication is administered in conjunction with intravenous normal saline, and allowed ... In some cases, usually where longer strictures are present, a rapidly metabolized hypnotic agent such as propofol may be ... and the urinary meatus is cleansed with an appropriate surgical cleansing agent (scrub), usually containing Povidone-iodine, ...
"Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue". Antimicrobial Agents and ... Antimicrobial Agents and Chemotherapy. 42 (10): 2626-9. doi:10.1128/aac.42.10.2626. PMC 105908. PMID 9756766. Müller M, dela ...
ATC code A07 Antidiarrheals, intestinal anti-inflammatory/anti-infective agents Mutschler, Ernst; Schäfer-Korting, Monika (2001 ... An anti-diarrhoeal drug (or anti-diarrheal drug in American English) is any medication which provides symptomatic relief for ... Absorbents absorb toxic substances that cause infective diarrhoea, methylcellulose is an absorbent. Anti-inflammatory compounds ... Bulking agents like methylcellulose, guar gum or plant fibre (bran, sterculia, isabgol, etc.) are used for diarrhoea in ...
ISBN 978-0-85404-596-9. v t e (Drugs, Anti-infective agents, All stub articles, Pharmacology stubs). ... platinum containing anticancer agents gold salts such as auranofin - anti-inflammatory for treatment of arthritis silver ... 2005). Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine. John Wiley and Sons. ISBN 978 ... Examples of metallopharmaceuticals include: bismuth subsalicylate - a mild anti-diarrheal also used in treating peptic ulcers ...
Expert Review of Anti-infective Therapy. 17 (1): 51-56. doi:10.1080/14787210.2018.1555241. PMC 6376865. PMID 30501436. (ECHA ... "Oxfendazole". Gonzalez AE, Codd EE, Horton J, Garcia HH, Gilman RH (January 2019). "Oxfendazole: a promising agent for the ...
Antibiotic and chemotherapy anti-infective agents and their use in therapy (9th ed.). Edinburgh: Saunders Elsevier. ISBN 0-7020 ... Kominek, L. A. (1 February 1972). "Biosynthesis of Novobiocin by Streptomyces niveus". Antimicrobial Agents and Chemotherapy. 1 ...
"The MEP pathway and the Development of Inhibitors as Potential Anti-Infective Agents". Med. Chem. Commun. 3 (4): 418-433. doi: ... "The MEP pathway and the Development of Inhibitors as Potential Anti-Infective Agents". Med. Chem. Commun. 3 (4): 418-433. doi: ...
Niedner R (1997). "Cytotoxicity and sensitization of povidone-iodine and other frequently used anti-infective agents". ... This agent exhibits a broad range of microbiocidal activity against bacteria, fungi, protozoa, and viruses. Slow release of ... They carried out tests in vitro to demonstrate anti-bacterial activity, and found that the complex was less toxic in mice than ... Kutscher, Bernhard (2020). "Dermatologicals (D), 4. Antiseptics and Disinfectants (D08), Anti‐Acne Preparations (D10), and ...
Antibiotic and chemotherapy anti-infective agents and their use in therapy (9th ed.). Edinburgh: Saunders Elsevier. ISBN 978-0- ... Antimicrobial Agents and Chemotherapy. 44 (3): 647-650. doi:10.1128/AAC.44.3.647-650.2000. PMC 89740. PMID 10681332. Hidaka, ...
Hemphill A, Mueller J, Esposito M (2006). "Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of ... a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther. 2 (1): 43-9. doi:10.1586/14787210.2.1.43. PMID 15482170 ... A causative agent for eye keratitis infection". Spectrochimica Acta Part A: Molecular Spectroscopy. 153: 714-21. Bibcode: ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed ...
Expert Review of Anti-Infective Therapy. 10 (4): 459-73. doi:10.1586/eri.12.25. PMID 22512755. S2CID 31496981. García-Salguero ... November 2010). "Synthesis and Spectrum of the Neoglycoside ACHN-490". Antimicrob Agents Chemother. 54 (11): 4636-4642. doi: ... Antimicrob Agents Chemother. 59 (10): 5959-66. doi:10.1128/AAC.00873-15. PMC 4576036. PMID 26169398. Clinical trial number ...
... anti-infectives". Expert Opinion on Investigational Drugs. 16 (1): 1-10. doi:10.1517/13543784.16.1.1. PMID 17155849. S2CID ... Alovudine (fluorothymidine) is an antiviral agent which was being developed by Medivir. It was discontinued after a Phase II ...
Carod-Artal, Francisco Javier (2015). "Post-Ebolavirus disease syndrome: what do we know?". Expert Review of Anti-infective ... was being treated using a highly experimental anti-viral agent called GS5734, and had significantly improved, although she ...
All articles with unsourced statements, Articles with unsourced statements from June 2022, Anti-infective agents). ... Therefore, it is a therapeutic priority to find effective anti-prion drugs.[citation needed] The disease progression in prion ... Mercer, Robert CC; Harris, David A (1 February 2019). "Identification of anti-prion drugs and targets using toxicity-based ...
The teratogenic risks of antipsychotic agents are small, but are higher with lithium and anti-convulsant agents. Carbamazepine ... Infective delirium hardly ever starts during pregnancy, and usually begins in the first postpartum week. The onset of sepsis ... These mothers require sedation with anti-psychotic (neuroleptic) agents, but are liable to extrapyramidal symptoms, including ... The primary pathology is in the placenta, which secretes an anti-angiogenic factor in response to ischaemia, leading to ...
Expert Review of Anti-infective Therapy. 10 (2): 185-95. doi:10.1586/eri.11.166. PMC 3292282. PMID 22339192. Federaal ... More careful use of antimicrobial agents, such as antibiotics, is also considered vital. As many hospital-acquired infections ... U.S. Department of Defense-funded clinical trials, as presented at the Interscience Conference on Antimicrobial Agents and ... Michels, H.T. (2006), Anti-Microbial Characteristics of Copper, ASTM Standardization News, October, pp. 28-31 Wang, Meng; Wei, ...
Maresso AW, Schneewind O (March 2008). "Sortase as a target of anti-infective therapy". Pharmacological Reviews. 60 (1): 128-41 ... Cossart P, Jonquières R (May 2000). "Sortase, a universal target for therapeutic agents against gram-positive bacteria?". ...
... the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of ... Agents. 31 (3): 189-92. doi:10.1016/j.ijantimicag.2007.11.010. PMID 18248798. Abraham EP (1987). "Cephalosporins 1945-1986". ... and the impact of anti-infective drugs and vaccines was significant mainly after World War II. In 1928, Alexander Fleming ... The top ten best-selling drugs of 2013 totaled $75.6 billion in sales, with the anti-inflammatory drug Humira being the best- ...
Expert Review of Anti-infective Therapy. 4 (2): 261-275. doi:10.1586/14787210.4.2.261. ISSN 1478-7210. PMID 16597207. S2CID ... Antimicrobial Agents and Chemotherapy. 31 (8): 1231-3. doi:10.1128/AAC.31.8.1231. ISSN 0066-4804. PMC 174909. PMID 3307619. ... Antimicrobial Agents and Chemotherapy. 31 (8): 1231-3. doi:10.1128/aac.31.8.1231. PMC 174909. PMID 3307619. "Alexander Fleming ...
Furthermore, Anti-CD3 and Anti-CD28 antibodies (CD28-SuperMAB) have also shown to be highly potent superantigens (and can ... Llewelyn M, Cohen J (March 2002). "Superantigens: microbial agents that corrupt immunity". Lancet Infect Dis. 2 (3): 156-62. ... 2013) Superantigens are critical for Staphylococcus aureus infective endocarditis, sepsis, and acute kidney injury. MBio 4: ... "Defective T cell Receptor-mediated Signal Transduction in Memory CD4 T Lymphocytes Exposed to Superantigen or anti-T cell ...
Both gram positive and gram negative infections are commonly spread through the blood from an infective source; but can be ... Risk of septic arthritis increases with anti-tumor necrosis factor alpha treatment. Immunosuppressive medication Intravenous ... or joint infection is the invasion of a joint by an infectious agent resulting in joint inflammation. Generally speaking, ...
Milne, G. W. A. (November 2017). Ashgate Handbook of Anti-Infective Agents: An International Guide to 1, 600 Drugs in Current ... which has a size of 59,187 daltons and is an anti-viral agent. ...
Expert Review of Anti-infective Therapy. 6 (5): 593-600. doi:10.1586/14787210.6.5.593. PMID 18847400. S2CID 13158593. Durante- ... These agents exhibit a post-antibiotic effect in which there is no or very little drug level detectable in blood, but there ... Agents Chemother. 43 (4): 727-37. doi:10.1128/AAC.43.4.727. PMC 89199. PMID 10103173. ME Levison, MD, 2012, Aminoglycosides, ... It is derived from Streptomyces griseus and is the earliest modern agent used against tuberculosis. Streptomycin lacks the ...
It has surfactant, antiseptic, and anti-infective properties, and it is used as a topical antimicrobial agent in first aid ... It is also found in cosmetics and toiletries such as soap, mouthwashes, anti-itch ointments, and antibacterial moist towelettes ...
Yellow mercuric oxide is not recognized as a safe and effective ophthalmic anti-infective ingredient. The FDA also regulates ... Fat is another agent that participates in the reduction of the mercury toxicity. In fact, higher LDL levels has been proved to ... Selenium for example works as a protective agent against mercury toxicity obtained through fish intake. Other nutrients such as ...
Wiwanitkit V (July 2010). "Dengue fever: diagnosis and treatment". Expert Review of Anti-Infective Therapy. 8 (7): 841-45. doi: ... August 2009). "Emerging infectious disease agents and their potential threat to transfusion safety". Transfusion. 49 (Suppl 2 ... International Anti-Dengue Day is observed every year on 15 June. The idea was first agreed upon in 2010 with the first event ... Paracetamol (acetaminophen) is recommended instead of nonsteroidal anti-inflammatory drugs (NSAIDs) for fever reduction and ...
Antiseptic A product that reduces the presence of infective agents. ARB Angiotensisn Receptor Blocker. An agent which ... Anti-diabetic drug A kind of medication that helps a person with diabetes control the level of glucose (sugar) in the blood so ... See also: Oral hypoglycemic agents. One of the sulfonylureas. (Amaryl) Glipizide A pill taken to lower the level of glucose ( ... Oral glucose tolerance test (OGTT) Oral hypoglycemic agents Pills or capsules that people take to lower the level of glucose ( ...
Patients with prolonged infection of D. latum must also undergo B12 supplementations along with anti-parasitics such as ... List of parasites (human) Muratov, IV; Posokhov, PS (1988). "Causative agent of human diphyllobothriasis--Diphyllobothrium ... The plerocercoid larvae are the infective stage for the definitive host (including humans). Because humans do not generally eat ...
"Safety and Efficacy of a Novel Vaginal Anti-infective, TOL-463, in the Treatment of Bacterial Vaginosis and Vulvovaginal ... The reaction is typically driven by a dehydrating agent, such as concentrated sulfuric acid: B(OH)3 + 3 ROH → B(OR)3 + 3 H2O ... Indeed, it is often used in conjonction with guar gum as cross-linking and gelling agent for controlling the viscosity and the ... Boric acid is used in high-voltage/high-current expulsion-type electrical fuses as a de-ionization/extinguishing agent. During ...
Expert Review of Anti-Infective Therapy. 10 (12): 1359-61. doi:10.1586/eri.12.143. PMC 4780314. PMID 23253311. Arbuckle JH, ... current antiviral agents include aciclovir, penciclovir, foscarnet, and docosanol. Aciclovir acts as a nucleoside analog which ... As seen by most mainstream antiviral agents, the mechanism of treatment for HSV historically is via the inhibition of viral ... From acyclovir to direct-acting antiviral agents (DAAs) for Hepatitis C". Medicina Universitaria. 17 (68): 165-174. doi:10.1016 ...
... particularly in pharmacological agents with narrow therapeutic index such as anticancer and anti-infective medications. In the ...
... anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122.085 - anti-bacterial agents MeSH D27.505 ... anti-infective agents, local MeSH D27.505.954.122.237 - anti-infective agents, urinary MeSH D27.505.954.122.250 - antiparasitic ... renal agents MeSH D27.505.954.613.056 - anti-infective agents, urinary MeSH D27.505.954.613.860 - uricosuric agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ...
His third hypothesis proposed that the agent could be an antibody if the antibody was its own target antigen, as such an ... Nailwal H, Chan FK (2019). "Necroptosis in anti-viral inflammation". Nature. 26 (1): 4-13. doi:10.1038/s41418-018-0172-x. PMC ... Adams DH, Field EJ (September 1968). "The infective process in scrapie". Lancet. 2 (7570): 714-16. doi:10.1016/s0140-6736(68) ... "Prion infectious agent". Encyclopaedia Britannica. Archived from the original on May 16, 2018. Retrieved May 15, 2018. Prusiner ...
Expert Review of Anti-Infective Therapy. 5 (3): 365-83. doi:10.1586/14787210.5.3.365. PMID 17547502. S2CID 68837323. Benli A, ... Antimicrobial Agents and Chemotherapy. 40 (4): 829-34. doi:10.1128/AAC.40.4.829. PMC 163214. PMID 8849235. Rice LB, Carias LL, ... Thus piperacillin is sometimes referred to as an "anti-pseudomonal penicillin". When used alone, piperacillin lacks strong ... Antimicrobial Agents and Chemotherapy. 23 (6): 881-7. doi:10.1128/aac.23.6.881. PMC 184992. PMID 6225390. Wise R, Logan M, ...
Expert Review of Anti-Infective Therapy. 10 (4): 487-99. doi:10.1586/eri.12.20. PMID 22512757. S2CID 207218803. Taylor-Robinson ... No procedure tests for all infectious agents. STI tests may be used for a number of reasons: as a diagnostic test to determine ... The amount of contact with infective sources which causes infection varies with each pathogen but in all cases, a disease may ... which interferes with its ability to fight off disease-causing agents. The virus kills CD4 cells, which are white blood cells ...
In the presence of an infectious agent, such as bacteria, viruses, viroids, etc., the immune response of the body is to inhibit ... Fever can be differentiated from hyperthermia by the circumstances surrounding it and its response to anti-pyretic medications ... in infective endocarditis or brucellosis). Pel-Ebstein fever is a cyclic fever that is rarely seen in patients with Hodgkin's ... infective endocarditis, tuberculosis, or typhus. Intermittent fever is present only for a certain period, later cycling back to ...
Elkin S, Geddes D (2003). "Pseudomonal infection in cystic fibrosis: the battle continues". Expert Review of Anti-infective ... nov., the causative agent of bacterial haemorrhagic ascites of ayu, Plecoglossus altivelis". Int. J. Syst. Evol. Microbiol. 50 ...
It remains infective for up to two hours in that airspace or nearby surfaces. Measles is so contagious that if one person has ... German anti-vaccination campaigner and HIV/AIDS denialist Stefan Lanka posed a challenge on his website in 2011, offering a sum ... July 2007). "Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity". Antimicrobial Agents and ... "Amid Measles Outbreak, Anti-Vaxx Parents Have Put Others' Babies At Risk". MSN. Archived from the original on 30 March 2019. ...
Considering antibody response, anti-cercarial IgM culminates 15 DPI, while anti-cercarial IgY reaches a peak 30 DPI. Ducks ... Cercariae, infective larvae, exit the snail and penetrate the skin of an avian host. After penetration of the host's skin, they ... Marszewska A, Strzała T, Cichy A, Dąbrowska GB, Żbikowska E (December 2018). "Agents of swimmer's itch-dangerous minority in ... On the contrary, anti-inflammatory IL-4 and IL-10 dominate in mice infected repeatedly which also secrete large amounts of ...
A study is published in China about the effectiveness of treating PUD with an antibacterial agent. July 31: The New York Times ... lending credence to both the infective theory and the hyperacidity theory as being causes of peptic ulcer disease. A single ... pylori even prevents bleeding from ulcers that is caused by aspirin and non-steroidal anti-inflammatory drugs. 2002 The ... Bismuth is an antibacterial agent, although this is not recognized by Ramsey. J. Robin Warren first observes H. pylori in a ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S ...
Antimicrobial agents and chemotherapy : AAC.. *. v.1(1972)- Access via ASM for Pitt and UPMC users ... International journal of antimicrobial agents. *. v.29(2007)- Access via ClinicalKey for Pitt and UPMC users ...
The global anti-infective agents market is estimated to have reached $109bn in 2018 and is expected to grow at a CAGR of 4.2% ... Visiongain has published a new pharma report Anti-infective Agents Market Report: Anti-viral Infections, Anti-bacterial ... The global anti-infective agents market is estimated to have reached $109bn in 2018 and is expected to grow at a CAGR of 4.2% ... "Anti-Infective Agents market set to grow to $141bn by 2024" says new Visiongain report. 09 September 2019. Pharma ...
Anti-Bacterial Agents. Anti-Infective Agents. To Top. *For Patients and Families ...
Anti-Infectives. The primary use of anti-infectives (which include Antimicrobial Agents), is to kill or inhibit the growth of ... Anti-infective agents that are too toxic to be used systemically (such as bleach or antiseptics) are not included in the ...
Anti-infective Agents. Class Summary. Anti-infectives such as metronidazole and tigecycline are effective against many types of ... This agent is a drug combination of beta-lactamase inhibitor with ampicillin. It is used as a single agent and interferes with ... This agent is a drug combination of beta-lactamase inhibitor with piperacillin. It has activity against some gram-positive ... Antibiotic agents are effective in decreasing the rate of postoperative wound infection and in improving outcome in patients ...
Immune modulation by infectious agents / edited by Wolfgang Zschiesche ; with contributions by J. Denner ... [et al.] by ... Practical guide to antimicrobial agents / Michael Ginsberg, Ira Tager. by Ginsberg, Michael , Tager, Ira. ...
Antitrichomonal Agents are agents used to treat trichomonas infections ... Antitrichomonal Agents "Antitrichomonal Agents (Antitrichomonals)" Antitrichomonal Agents. In our body, Antitrichomonal Agents ... Antitrichomonal Agents ⌊Phenomena (Phenomenon concepts). ⌊Role Phenomena (Role Concepts). ⌊Physicochemical Roles. ⌊Applications ... Anti-Infective Agents. ⌊Antiparasitic Agents. ⌊Antiprotozoal Agents. ⌊Antitrichomonal Agents. Antiprotozoal Agents ⌊. ...
Anti-infective Agents. *. Baraclude (entecavir) Tablets and Oral Solution Neurologic Agents. *. Namenda (memantine) Oral ...
Anti-Infective Agents. *. Antiparasitic Agents. *. Antimalarials. *. Antiprotozoal Agents. Disclaimer: Information presented in ...
Anti-Infective Agents / analysis * Anti-Infective Agents / pharmacology* * Chromatography, High Pressure Liquid ...
Allergy inhibitors;, Anti-infective agents; Antitumor agents; Autoimmune disease; Bacterial infection; Immunostimulants; ... Compounds which interfere with microbial quorum sensing mechanism for use as anti-infective and immunomodulatory agents. ... Compounds which interfere with microbial quorum sensing mechanism for use as anti-infective and immunomodulatory agents. WO ... I and II, and methods that include the use of I and II as anti-infective compds. that potentiate the host immune response or ...
Sulfacetamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus ...
Anti-Bacterial Agents. Anti-Infective Agents. Protein Synthesis Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ... Dermatologic Agents. Anti-Inflammatory Agents, Non-Steroidal. Analgesics, Non-Narcotic. Analgesics. Sensory System Agents. ... Peripheral Nervous System Agents. Physiological Effects of Drugs. Anti-Inflammatory Agents. Antirheumatic Agents. ...
Given no specific antiviral therapy for COVID-19 and the ready availability of remdesvir as a potential antiviral agent, based ... Given no specific antiviral therapy for COVID-19 and the ready availability of remdesvir as a potential antiviral agent, based ... Must agree not to enroll in another study of an investigational agent prior to completion of Day 28 of study. ... Antiviral Agents. Anti-Infective Agents. To Top. *For Patients and Families. *For Researchers ...
Anti-Infective Agents. Antibacterial Agents. Penicillins. Disclaimer: Information presented in this database is not meant as a ...
Anti-Infective Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Infective Agents) ... Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents) ... Recent Advances in Anti-Infective Drug Discovery Formerly Recent Patents on Anti-Infective Drug Discovery ... Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents) ...
Many anti-infective agents interact with immunosuppressive regimens used in transplantation, placing patients at increased risk ... Less is known about the interactions with anti-proliferative agents and corticosteroids, with gaps in knowledge on the ... of interactions between calcineurin inhibitors and mammalian target of rapamycin inhibitors with anti-infective agents. ... the pharmacokinetic drug-drug interactions between antimetabolites and corticosteroids with commonly used anti-infective agents ...
Anti-Infective Agents. en_US. dc.subject.mesh. Communicable Diseases. en_US. ...
a. Anti-Infective Agents and Anticonvulsants.. Contraceptive effectiveness may be reduced when hormonal contraceptives are co- ... b. Anti-HIV Protease Inhibitors.. Several of the anti-HIV protease inhibitors have been studied with co-administration of oral ... The safety and efficacy of OC products may be affected with the co-administration of anti-HIV protease inhibitors. Health care ... providers should refer to the label of the individual anti-HIV protease inhibitors for further drug-drug interaction ...
Pharmacological Actions : Anti-Infective Agents : CK(66) : AC(40). Print Options. Some features are currently member only ...
... may offer novel chemical diversity for anti-infective drug searches. Plants provide many interesting compounds with anti- ... This could be especially challenging in the case of biological agents specifically designed to be weapons. A system must be in ... David L. Heymann, "Resistance to Anti-Infective Drugs and the Threat to Public Health," Cell 124 (February 24, 2006), pp. 671- ... can no longer be effectively treated with common anti-infective drugs," writes David L. Heymann of the World Health ...
... drugs and/or adjuvants in tuberculosis therapy are an interesting approach to prevent toxic effects and resistance to anti- ... drugs and/or adjuvants in tuberculosis therapy are an interesting approach to prevent toxic effects and resistance to anti- ... Therefore, therapeutic liquid mixtures formulated with anti-tuberculosis ... Therefore, therapeutic liquid mixtures formulated with anti-tuberculosis ...
Categories: Anti-Infective Agents Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Anti-Infective Agents. Recent Advances in Inflammation & Allergy Drug Discovery. Current Medicinal Chemistry ... Central Nervous System Agents in Medicinal Chemistry Transcranial Doppler Ultrasonography: Current Status. Current Medical ... Cardiovascular & Hematological Agents in Medicinal Chemistry Proteomics Approaches to Understand Linkage Between Alzheimers ... Current Medicinal Chemistry - Central Nervous System Agents Inflammatory Responses in Brain Ischemia. Current Medicinal ...
Anti-Infective Agents. Jiang J, Zhang Y, Indra AK, Ganguli-Indra G, Le MN, Wang H, Hollins RR, Reilly DA, Carlson MA, Gallo RL ...
  • Anti-infective drugs include: anti-viral therapeutics, antibiotics, anti-fungal agents and prophylactic treatments such as vaccines. (malaria.com)
  • The Clinical Operations Specialist will support Crestone's Medical Group and Program Management in the clinical development of small-molecule anti-infective therapeutics. (crestonepharma.com)
  • The primary use of anti-infectives (which include Antimicrobial Agents ), is to kill or inhibit the growth of organisms such as bacteria, parasites or fungi, thus limiting infection. (ratguide.com)
  • In most cases, however, systemic antimicrobial agents are preferred based on superior penetration and potency in the infected area. (merckvetmanual.com)
  • Program and abstracts of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA . Washington, DC: American Society for Microbiology, 2002. (nursingcenter.com)
  • An empirical report titled Global Anti-Infective Ophthalmic Market Growth 2021-2026 is released by MarketandResearch.biz with exclusive insight into key players by region with the competitive landscape of the market. (pharmiweb.com)
  • The report surveys the global Anti-Infective Ophthalmic market by the various side of the industry, including market size, market conditions, market trends, and forecast for 2021 to 2026 time-frame, with brief information on competitors and specific growth by key market drivers. (pharmiweb.com)
  • This drug is also a second-generation cephalosporin that is indicated as single agent for the management of infections caused by susceptible gram-positive cocci and gram-negative rods. (medscape.com)
  • In our body, Antitrichomonal Agents (Antitrichomonals) are exogenous substances used to treat trichomonas infections . (wellnessadvantage.com)
  • Given no specific antiviral therapy for COVID-19 and the ready availability of remdesvir as a potential antiviral agent, based on pre-clinical studies in SARS-CoV and MERS-CoV infections, this randomized, controlled, double blind trial will evaluate the efficacy and safety of remdesivir in patients hospitalized with severe COVID-19. (clinicaltrials.gov)
  • Triple-antibiotic ointment (TAO) is a safe and effective topical agent for preventing infections in minor skin trauma. (semanticscholar.org)
  • The Company is a consolidation of two existing private companies (Sepset Biosciences Inc. and ABT Innovations Inc.) that are both in the advanced development of both proprietary diagnostic tools, enabling the early and timely identification of severe sepsis as well as broad-spectrum therapeutic agents to address multidrug-resistant biofilm infections. (cw33.com)
  • There is established data regarding the level of evidence and magnitude of interactions between calcineurin inhibitors and mammalian target of rapamycin inhibitors with anti-infective agents. (annalsoftransplantation.com)
  • A major component of medical care is anti-infective and prevention of further infectious episodes by regular infusion of human immunoglobulin and antimicrobial therapy. (medscape.com)
  • Something capable of acting against infection , by inhibiting the spread of an infectious agent or by killing the infectious agent outright. (rxlist.com)
  • It is used as a single agent and interferes with bacterial cell wall synthesis during active replication, causing bactericidal activity against susceptible organisms. (medscape.com)
  • Gentamicin is an aminoglycoside antibiotic used for gram-negative coverage, as well as in combination with an agent against gram-positive organisms and another one against anaerobes. (medscape.com)
  • Such an approach should prevent pathogenic organisms from acquiring resistance to the protective anti-infective compds. (inrs.ca)
  • Her current research interests are metabolomics (primary and secondary metabolites) and bioactivities (anti-inflammatory and neuroprotection) of natural matrices, including both terrestrial and marine organisms. (benthamscience.com)
  • These agents work by binding to the 30S ribosome, inhibiting bacterial protein synthesis. (medscape.com)
  • 4. Synthesis of anti-infective drugs, anti-inflammatory medicines, vitamin-class medicines and central nervous system drugs. (sinochemi.com)
  • 5. With any serious infection requiring systemic anti-infective therapy within 14 days before randomization. (who.int)
  • Ironically enough, it was this systemic inflammatory reaction caused by 5-lipoxygenase that protected our ancestors from infective diseases. (our-arthritis.com)
  • The Surgical Infection Society recommends starting prophylactic antibiotics before surgery, using appropriate spectrum agents for less than 24 hours for nonperforated appendicitis and for less than 5 days for perforated appendicitis. (medscape.com)
  • In September, the US Food and Drug Administration (FDA) approved the first agent in a new class of antibiotics called cyclic lipopeptide antibacterial agents. (medscape.com)
  • Anti-infective is a general term that encompasses antibacterials, antibiotics, antifungals, antiprotozoans and antivirals. (rxlist.com)
  • According to this formal meaning, sulfa drugs, quinolones, and other agents commonly used in this way are not antibiotics. (bvsalud.org)
  • Anti-infective agents that are too toxic to be used systemically (such as bleach or antiseptics) are not included in the Medication Guide at this time. (ratguide.com)
  • Pentamidine is an anti-infective agent that helps to treat or prevent pneumonia caused by the organism Pneumocystis jiroveci (carinii). (medlineplus.gov)
  • Retapamulin, a novel topical antibacterial agent, will probably replace the use of the old mupirocin and fusidic acid in the management of acne and atopic dermatitis. (semanticscholar.org)
  • Topical anti-infective agents are used extensively in surgery for antisepsis of the surgical site and the surgeon's hands, and to disinfect surgical instruments, apparel, and hospital premises. (merckvetmanual.com)
  • Antibiotic agents are effective in decreasing the rate of postoperative wound infection and in improving outcome in patients with appendiceal abscess or septicemia. (medscape.com)
  • While pulp capping using a variety of materials has been applied clinically to preserve the health and vitality of the dental pulp and induce dentin repair no material meets all the anti-infection, anti-inflammation, and promoting pulp tissue regeneration criteria. (rsc.org)
  • In this context, WNT proteins have both pro- and anti-inflammatory effects on macrophages and other cells of the immune system as well as on bacterial number development during infection. (fz-borstel.de)
  • Because of the risk of visual loss from cataract, glaucoma and intraocular infection with the use of intravitreal steroids, Ozurdex tends to be reserved for use in patients unresponsive to anti-VEGF therapy for centre-involving DMO. (docksci.com)
  • Less is known about the interactions with anti-proliferative agents and corticosteroids, with gaps in knowledge on the appropriate management of these interactions. (annalsoftransplantation.com)
  • The objective of this review was to highlight the pharmacokinetic drug-drug interactions between antimetabolites and corticosteroids with commonly used anti-infective agents. (annalsoftransplantation.com)
  • Many anti-infective agents interact with immunosuppressive regimens used in transplantation, placing patients at increased risk for adverse drug reactions and prolonged hospitalizations. (annalsoftransplantation.com)
  • Interested in helping further our research into novel antibacterial agents? (crestonepharma.com)
  • Therefore, therapeutic liquid mixtures formulated with anti-tuberculosis drugs and/or adjuvants in tuberculosis therapy are an interesting approach to prevent toxic effects and resistance to anti-tuberculosis drugs. (frontiersin.org)
  • ADRs were high among HIV-positive patients (82.9%), mainly due to anti-tuberculosis drugs. (who.int)
  • The anti-infective drugs market will jump to $66 billion by 2013, according to a recently published report. (malaria.com)
  • 39,40 It has been confirmed through animal experiments that frankincense extracts possess a strong anti-inflammatory effect, especially for mitigating joint inflammation in arthritis. (our-arthritis.com)
  • His current role is Global Products Manager and Global Alliance Manager for Tralokinumab, an anti-IL-13 monoclonal antibody for the treatment of patients with severe asthma presently undergoing phase III clinical trials. (eurekaselect.com)
  • This agent is a drug combination of beta-lactamase inhibitor with piperacillin. (medscape.com)
  • Moreover, treatment of M. tuberculosis -infected mice with a combination of a pharmacological ACC2 inhibitor and the anti-TB drug isoniazid (INH) reduced lung TAG and cytokine levels, as well as lung weights, compared with treatment with INH alone. (fz-borstel.de)
  • Train to play a vital role in the discovery, development and testing of therapeutic agents to improve global health. (bath.ac.uk)
  • Pharmacologists aim to develop safe and effective therapeutic agents. (bath.ac.uk)
  • Anti-Bacterial Agents more aptly describe these substances. (bvsalud.org)
  • Compounds which interfere with microbial quorum sensing mechanism for use as anti-infective and immunomodulatory agents. (inrs.ca)
  • To assess the effect of adding zinc oxide nanoparticles to dental adhesives on their anti-microbial and bond strength properties. (bvsalud.org)
  • Incorporation of zinc oxide nanoparticles into dental adhesives increases their anti-microbial properties without affecting their bond strength. (bvsalud.org)
  • This prospective observational study, evaluates gram-positive anti-bacterial utilisations in intensive care units (ICUs) with various evaluation criteria, to determine the frequency of inappropriate usage and the intervention targets required to ensure optimum use. (biomedcentral.com)
  • 2012]. Macular laser Before the advent of anti-VEGF therapy, the standard of care for DMO management was macular laser. (docksci.com)
  • Indole-3-carbinol (I3C) is an active component of cruciferous vegetables which is considered a promising antineoplastic agent. (usda.gov)
  • Issn 1923-4155 print single agent indicated for 30% received a urinalysis by 3rd parties. (eliteplatinumlimo.com)
  • In 2018, the hospital pharmacy segment dominated the distribution channel of the anti-infective agents market. (visiongain.com)
  • As well as the proven efficacy of intravitreal anti-vascular endothelial growth factor (anti-VEGF) agents, phase II and III clinical trials of Ozurdex intravitreal dexamethasone implants for DMO have also demonstrated a mean increase in visual acuity and corresponding mean reduction in central macular thickness, particularly in pseudophakic eyes. (docksci.com)
  • I and II, and methods that include the use of I and II as anti-infective compds. (inrs.ca)
  • In view of emerging drug-resistant tuberculosis (TB), host-directed adjunct therapies are urgently needed to improve treatment outcomes with currently available anti-TB therapies. (fz-borstel.de)
  • The global anti-infective agents market is estimated to have reached $109bn in 2018 and is expected to grow at a CAGR of 4.2% during the forecast period. (visiongain.com)
  • The global anti-infective agents market is one that is driven by innovation. (visiongain.com)
  • The report presents a complete assessment of the global Anti-Infective Ophthalmic market and contains a future trend, current growth factors, and verified market data. (pharmiweb.com)
  • The report examines the essence of the global Anti-Infective Ophthalmic market in many regions around the world. (pharmiweb.com)
  • The report consists of discussions of key vendors in the global Anti-Infective Ophthalmic market industry on brand overview, profile, market revenue, and financial analysis. (pharmiweb.com)
  • This is vital for maintaining the rich pipeline of anti-infective agents seen in the market today. (visiongain.com)
  • When used as a single agent, it inhibits biosynthesis of cell wall mucopeptide and is effective during active multiplication stages. (medscape.com)
  • American urological association of an agent with dcc as active tubular secretion. (eliteplatinumlimo.com)
  • The first tree number of the term Anti-Infective Agents (formerly D20 and D27.505.102) was deleted. (bvsalud.org)