Anti hiv agents. Medical search

A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.

Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).

Development of neutralizing antibodies in individuals who have been exposed to the human immunodeficiency virus (HIV/HTLV-III/LAV).

Studies of the number of cases where human immunodeficiency virus (HIV) is present in a specific population at a designated time. The presence in a given individual is determined by the finding of HIV antibodies in the serum (HIV SEROPOSITIVITY).

Immune status consisting of non-production of HIV antibodies, as determined by various serological tests.

Short course antiretroviral regimens to reduce maternal transmission of HIV.(1/7501)

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HIV-associated nephropathy is a late, not early, manifestation of HIV-1 infection. (2/7501)

BACKGROUND: Human immunodeficiency virus-associated nephropathy (HIVAN) can be the initial presentation of HIV-1 infection. As a result, many have assumed that HIVAN can occur at any point in the infection. This issue has important implications for appropriate therapy and, perhaps, for pathogenesis. Since the development of new case definitions for acquired immunodeficiency syndrome (AIDS) and better tools to assess infection, the relationship of HIVAN to the time of AIDS infection has not been addressed. In this study, we reassessed the stage of infection at the time of HIVAN diagnosis in 10 patients, and we reviewed all previously published cases applying the new case definitions to assess stage of infection. METHODS: HIVAN was confirmed by kidney biopsy in HIV seropositive patients with azotemia and/or proteinuria. CD4+ cell count and plasma HIV-1 RNA copy number were measured. We also reviewed all published cases of HIVAN to determine if AIDS-defining conditions, by current Centers for Disease Control definitions, were present in patients with biopsy-proven HIVAN. RESULTS: Twenty HIV-1 seropositive patients with proteinuria and an elevated creatinine concentration were biopsied. HIVAN was the single most common cause of renal disease. CD4+ cell count was below 200/mm3 in all patients with HIVAN, fulfilling Centers for Disease Control criteria for an AIDS-defining condition. HIV-1 plasma RNA was detectable in all patients with HIVAN. In reviewing previous reports, an AIDS-defining condition was present in virtually all patients with HIVAN. CONCLUSION: HIVAN develops late, not early, in the course of HIV-1 infection following the development of AIDS. This likely accounts for the poor prognosis noted in previous publications and has implications for pathogenesis. In addition, given the detectable viral RNA levels, highly active antiretroviral therapy is indicated in HIVAN. Highly active antiretroviral therapy may improve survival as well as alter the natural history of HIVAN. (+info)

Clinical experience and choice of drug therapy for human immunodeficiency virus disease. (3/7501)

To determine if providers experienced in the management of human immunodeficiency virus (HIV) disease preferred different treatment regimens than providers with less experience, we analyzed data from a national survey of primary care providers' preferred regimens for the management of 30 HIV-related medical conditions. We mailed questionnaires to 999 correct addresses of providers in > 20 cities in the United States in May 1996. We received 524 responses (response rate, 52%). We found a statistically significant association between the number of HIV-infected patients cared for by the provider and the likelihood that the provider would report prescribing highly active antiretroviral therapy and multidrug combinations for treatment of opportunistic infections. Providers with few HIV-infected patients were substantially less likely to report using new therapeutic regimens or new diagnostic tools. We concluded that the preferred regimens of experienced providers are more likely to be consistent with the latest information on treatment for HIV disease than are those of less experienced providers. (+info)

Issues in the treatment of active tuberculosis in human immunodeficiency virus-infected patients. (4/7501)

Most HIV-infected patients with tuberculosis can be treated satisfactorily with standard regimens with expectations of good results. Treatment of tuberculosis in these patients has been complicated by the introduction of HAART, which relies on drugs that interfere with the most potent class of antituberculous medications. Rifampin-free regimens or regimens that employ rifabutin may be acceptable strategies for patients who are receiving protease inhibitors, although these regimens have not been rigorously evaluated in patients with AIDS. At present, there is good reason to believe that a 6-month course of a rifabutin-containing regimen or a 9-12-month course of a regimen of streptomycin, isoniazid, and pyrazinamide should be adequate therapy for most patients with drug-susceptible disease. As the treatment of HIV infection with antiretroviral agents evolves, the treatment of tuberculosis in patients with AIDS is likely to evolve as well. This will require careful coordination of antituberculosis and antiretroviral therapies. (+info)

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (5/7501)

8-Difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyp hen yl)-1- piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) has recently been identified as a potent and selective inhibitor of human immunodeficiency virus type 1 (HIV-1) transcription. In this study, we examined several combinations of K-12 and other antiretroviral agents for their inhibitory effects on HIV-1 replication in acutely and chronically infected cell cultures. Combinations of K-12 and a reverse transcriptase (RT) inhibitor, either zidovudine, lamivudine, or nevirapine, synergistically inhibited HIV-1 replication in acutely infected MT-4 cells. The combination of K-12 and the protease inhibitor nelfinavir (NFV) also synergistically inhibited HIV-1, whereas the synergism of this combination was weaker than that of the combinations with the RT inhibitors. K-12 did not enhance the cytotoxicities of RT and protease inhibitors. Synergism of the combinations was also observed in acutely infected peripheral blood mononuclear cells. The combination of K-12 and cepharanthine, a nuclear factor kappa B inhibitor, synergistically inhibited HIV-1 production in tumor necrosis factor alpha-stimulated U1 cells, a promonocytic cell line chronically infected with the virus. In contrast, additive inhibition was observed for the combination of K-12 and NFV. These results indicate that the combinations of K-12 and clinically available antiretroviral agents may have potential as chemotherapeutic modalities for the treatment of HIV-1 infection. (+info)

A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients. (6/7501)

The effects of multiple opportunistic infection medications on stavudine pharmacokinetics were evaluated. Ten patients with CD4 counts of less than 200 cells/mm3 received stavudine (40 mg twice daily) in combination with one to three other drugs used to treat opportunistic infections. Serial blood samples for stavudine concentrations were collected after 1 week of therapy on each regimen and assayed for stavudine by using a validated high-pressure liquid chromatography method. Although the maximum concentration of drug in serum was significantly decreased when the drug was given in combination with three opportunistic infection medications, the area under the concentration-time curve did not significantly differ across various treatment regimens. Stavudine exposure was not significantly altered by multiple concomitant medications. Side effects were minor throughout the 3-month study period. The tolerability of stavudine, combined with its lack of drug interactions, makes it an attractive agent for use as part of a combination regimen. (+info)

Lack of absorption of didanosine after rectal administration in human immunodeficiency virus-infected patients. (7/7501)

The feasibility of rectal administration of didanosine (DDI) was studied in six human immunodeficiency virus-infected patients. After oral intake of a DDI solution (100 mg/m2 of body surface area) combined with an antacid (Maalox), pharmacokinetic parametric values were in accordance with previously published data; the mean +/- standard deviation for terminal half-life was 59.5 +/- 15.0 min, that for peak concentration was 5.2 +/- 3.9 mumol/liter, and that for the area under the time-concentration curve (AUC) was 494 +/- 412 min.mumol/liter. After rectal administration of a similarly prepared DDI solution (100 mg/m2 of body surface area), plasma DDI levels were below the detection limit (0.1 mumol/liter) at all time points in five of the six patients, and in the remaining patient the AUC after rectal application was only 5% of that after oral administration. We conclude that oral administration of DDI cannot be easily replaced by rectal application. (+info)

Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine. (8/7501)

The replication of recombinant multidrug-resistant HIV-1 clones modeled on clinically derived resistant HIV-1 strains from patients receiving long-term combination therapy with zidovudine (AZT) plus 2',3'-dideoxycytidine was found to regain sensitivity to AZT and stavudine (D4T) as a consequence of a pharmacologically induced decrease in de novo dTMP synthesis. The host-cell system used was phytohemagglutinin-stimulated peripheral blood mononuclear cells; dTMP and dTTP depletion were induced by single exposures to a low level of the thymidylate synthase inhibitor 5-fluorouracil (5-FU) or its deoxynucleoside, 2'-deoxy-5-fluorouridine. The host-cell response to the latter was biphasic: a very rapid decrease in the rate of de novo dTMP formation and, consequently, in intracellular dTTP pools, followed by slower recovery in both indices over 3 to 24 h. With the additional presence of AZT or D4T, however, replication of the multidrug-resistant HIV-1 strains remained inhibited, indicating dependence of HIV DNA chain termination by AZT-5'-monophosphate or 2',3'-didehydro-2', 3'-dideoxythymidine-5'-monophosphate in these resistant strains on simultaneous inhibition of host-cell de novo synthesis of thymidine nucleotides. No effect on viability of control (uninfected) phytohemagglutinin-stimulated/peripheral blood mononuclear cells was noted on 6-day exposures to 5-FU or 2'-deoxy-5-fluorouridine alone or in combination with AZT or D4T, even at drug levels severalfold higher than those used in the viral inhibition studies. These studies may provide useful information for the potential clinical use of AZT/5-FU or D4T/5-FU combinations for the prevention or reversal of multidrug resistance associated with long-term dideoxynucleoside combination therapy. (+info)

... with both molecules showing promising anti-HIV activity. GS-CA1 functions by binding directly to the HIV capsid. This bonding ... April 2016). "Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication". Antimicrobial Agents and Chemotherapy. 60 (4): ... Ebselen shows anti-HIV activity in infected cell lines. Uracil based scaffolds such as bispyrimidine dione and tetrapyrimidine ... Because of this, drugs that specifically inhibit the HIV capsid are being developed in order to reduce the replication of HIV, ...

https://en.wikipedia.org/wiki/HIV_capsid_inhibition

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. International Journal of Antimicrobial Agents ... They are highly effective against HIV and have, since the 1990s, been a key component of anti-retroviral therapies for HIV/AIDS ... In common usage HIV usually implies HIV-1. HIV-1 protease is one of the best known aspartic proteases, and an attractive target ... The Stanford HIV RT and Protease Sequence Database (also called the "HIV Drug Resistance Database") was formed in 1998 with HIV ...

https://en.wikipedia.org/wiki/Discovery_and_development_of_HIV-protease_inhibitors

Reviriego, C (July 2011). "Chemokine CCR2/CCR5 Receptor Antagonist Anti-HIV Agent". Drugs of the Future. 36 (7): 511-7. doi: ... cite journal}}: Cite journal requires ,journal= (help) CROI 2013: CCR5/CCR2 Inhibitor Cenicriviroc Has Both Anti-HIV and Anti- ... HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks ... Inhibition of CCR2 may have an anti-inflammatory effect.[citation needed] A double-blind, randomized, placebo-controlled ...

https://en.wikipedia.org/wiki/Cenicriviroc

Zhang, Heping; Zembower, David; Chen, Zhidong (1997). "Structural analogues of the michellamine anti-HIV agents. Importance of ... Michellamine B is particularly active against the NID-DZ strain of HIV-2, which is mainly found in West Africa. The National ... Additionally, novel alkaloids korupensamines A, B, C and D, with anti-malarial activity, have been isolated from the plant. ... atropisomeric alkaloids which have been found to inhibit HIV viral replication. ...

https://en.wikipedia.org/wiki/Ancistrocladus_korupensis

Zhang, Heping; Zembower, David; Chen, Zhidong (October 1997). "Structural analogues of the michellamine anti-HIV agents. ... They have a broad range of effectiveness in vitro across most HIV strains, particularly the HIV-2 strain, which is found ... Michellamines are a group of atropisomeric alkaloid which have been found to be HIV viral replication inhibitors in vitro. It ... michellamine B is the most active against the NID-DZ strain of HIV-2. Michellamine A and B occur naturally in Ancistrocladus ...

https://en.wikipedia.org/wiki/Michellamine

Jung M, Lee S, Kim H (June 2000). "Recent studies on natural products as anti-HIV agents". Current Medicinal Chemistry. 7 (6): ... This process has been proven through test on several envelop viruses such as HIV and HSV. Also, the isoforms of the fatty acid ... Activity-structure relationships to design new bioactive agents". Combinatorial Chemistry & High Throughput Screening. 6 (6): ... anti-mycoplasma and hemolytic activities. The structure of the main congener consists of a peptide loop of seven amino acids (L ...

https://en.wikipedia.org/wiki/Surfactin

Zhan, Peng; Li, Zhenyu; Liu, Xinyong (September 2010). "Cosalane and its analogues: a unique class of anti-HIV agents". Mini ... a Novel Anti-HIV Agent Which Inhibits Multiple Features of Virus Reproduction". Journal of Medicinal Chemistry. 37 (19): 3040- ... synthesis and evaluation of 6-aryl-indenoisoquinolone derivatives dual targeting ERα and VEGFR-2 as anti-breast cancer agents ... Some of the compounds his group prepared include: the antileukemic agent nitidine chloride (III); corydaline, which possesses ...

https://en.wikipedia.org/wiki/Mark_Cushman

New York: W.H. Freeman (1997). Cragg, G. M.; Newman, D. J. (2003). "Plants as a source of anti-cancer and anti-HIV agents". ... they discovered the anti-HIV/AIDS properties of prostratin found in the bark of the mamala tree of Samoa. He was elected as ...

https://en.wikipedia.org/wiki/Paul_Alan_Cox

Anti-acne preparations, Anti-inflammatory agents, Hepatotoxins, Neuroprotective agents, NMDA receptor antagonists, PARP ... Copeland KF, Brooks JI (15 April 2010). "A Novel Use for an Old Drug: The Potential for Minocycline as Anti-HIV Adjuvant ... Minocycline significantly reduces concentrations of the anti-HIV drug atazanavir in the body. Minocycline is quickly and nearly ... Joks R, Durkin HG (December 2011). "Non-antibiotic properties of tetracyclines as anti-allergy and asthma drugs". Pharmacol. ...

https://en.wikipedia.org/wiki/Minocycline

Drug-resistant viruses are an inevitable consequence of prolonged exposure of HIV-1 to anti-HIV drugs. In the summer of 1981 ... This compound had been prepared in 1964 as a potential anti-cancer agent but was shown to be ineffective. In 1974 zidovudine ... The reverse transcriptase of HIV-1 has been the main foundation for the development of anti-HIV drugs. The first nucleoside ... "Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV", International Journal of Antimicrobial ...

https://en.wikipedia.org/wiki/Discovery_and_development_of_nucleoside_and_nucleotide_reverse-transcriptase_inhibitors

It is a potential antichagonistic agent and has shown to possess neuroprotective effects as well. It is also found to have anti ... It has shown significant antiviral activity against human hepatitis B virus, HIV and SARS-CoV. Cubebin Marcotullio, Maria; ... Cao, Xue-li; Xu, Jing; Bai, Ge; Zhang, Hong; Liu, Yan; Xiang, Jun-feng; Tang, Ya-lin (June 2013). "Isolation of anti-tumor ... It has also shown to reduce LPS induced nitric oxide production from macrophages.The anti-inflammatory property of hinokinin is ...

https://en.wikipedia.org/wiki/Hinokinin

Other diarylpyrimidine-analogues are currently being used as anti-HIV agents, notably rilpivirine. In 2009, the prescribing ... Muresan-Pop, M.; Macavei, S.; Turza, A.; Borodi, G. (2021-11-01). "New solvates and a salt of the anti-HIV compound etravirine ... "Appendix A: Key to Acronyms". Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. ... Rajput, Lalit; Sanphui, Palash; Desiraju, Gautam R. (2013-08-07). "New Solid Forms of the Anti-HIV Drug Etravirine: Salts, ...

https://en.wikipedia.org/wiki/Etravirine

Trichostatin A (TSA) and others are being investigated as anti-inflammatory agents. After the successful initial round of in ... "Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy". ... Adcock IM (April 2007). "HDAC inhibitors as anti-inflammatory agents". British Journal of Pharmacology. 150 (7): 829-31. doi: ... The goal is for HDAC inhibitors to flush HIV from the reservoirs it builds within the DNA of infected cells, followed by a ...

https://en.wikipedia.org/wiki/Histone_deacetylase_inhibitor

... a model for in vitro testing of potential anti-HIV drugs". Comp. Immunol. Microbiol. Infect. Dis. 24 (2): 113-22. doi:10.1016/ ... Agents Chemother. 31 (9): 1369-74. doi:10.1128/aac.31.9.1369. PMC 174944. PMID 2445282. Salvatori D, Vincenzetti S, Maury G, ... "HIV-1-associated central nervous system dysfunction." Krebs FC, Ross H, McAllister J, Wigdahl B. Frank KB, McKernan PA, Smith ... The relationship of visna and HIV as lentiviruses was first published in 1985 by visna researcher Janice E. Clements and ...

https://en.wikipedia.org/wiki/Visna-maedi_virus

"Histone deacetylase inhibitors as anti-neoplastic agents". Cancer Letters. 280 (2): 192-200. doi:10.1016/j.canlet.2009.03.013. ... Depletion of Latent HIV in CD4 Cells - Full Text View - ClinicalTrials.gov Batty N, Malouf GG, Issa JP (August 2009). " ... In addition, a clinical trial is studying valproic acid effects on the latent pools of HIV in infected persons. HDIs are ... Histone deacetylase inhibitors (HDIs) have a long history of use in psychiatry and neurology as mood stabilizers and anti- ...

https://en.wikipedia.org/wiki/Histone_deacetylase

Novel 3,28-Disubstituted Betulinic Acid Derivatives as Potent Anti-HIV Agents Aims/Hypothesis Out-licensing. iptechex ... The effects of betulinic acid as an anticancer agent in breast cancer is found to be cannabinoid receptor dependent. Betulinic ... C-3 esterification of betulinic acid led to the discovery of bevirimat, an HIV-1 maturation inhibitor patented by Rhone-Poulenc ... Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory ...

https://en.wikipedia.org/wiki/Betulinic_acid

Percudani R, Montanini B, Ottonello S (September 2005). "The anti-HIV cyanovirin-N domain is evolutionarily conserved and ... Agents Chemother. 47 (8): 2518-2525. doi:10.1128/aac.47.8.2518-2525.2003. PMC 166092. PMID 12878514. Wlodawer A, Botos I, Boyd ... "Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides". J. Biol. Chem. 277 ( ... Mori T, O'keefe BR, Smee DF, Turpin JA, Saucedo CJ, Gustafson KR, Blakeslee D, Buckheit R, Boyd MR (2003). "Potent anti- ...

https://en.wikipedia.org/wiki/CVNH_domain

McMahon, Moira (21 June 2007). "The Anti-Hepatitis B Drug Entecavir Inhibits HIV-1 Replication and Can Select HIV-1 Variants ... "Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents" (PDF). Panel on Antiretroviral ... but is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select ... 1992). "4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl purines and pyrimidines, a new class of anti-herpesvirus agents". ...

https://en.wikipedia.org/wiki/Entecavir

... s have been investigated as possible anti-inflammatory agents and evaluated on their anti-cancer and anti-oxidant ... June 2021). "Penetrating the Blood-Brain Barrier with New Peptide-Porphyrin Conjugates Having anti-HIV Activity". Bioconjugate ... Several porphyrin-peptide conjugates were found to have antiviral activity against HIV in vitro. Although not commercialized, ... antinociceptive and anti-inflammatory effects of porphyrins". Bioorganic & Medicinal Chemistry. 23 (10): 2529-2537. doi:10.1016 ...

https://en.wikipedia.org/wiki/Porphyrin

The discovery of FTC was first published in 1992 in Antimicrobial Agents and Chemotherapy as another new anti-HIV compound. The ... Schinazi is best known for his involvement in the discovery and/or development of innovative anti-HIV, HBV, and HCV drugs on ... This drug became one of the most successful antiviral agents used to combat HIV as part of fixed-dose combinations (including ... Antimicrobial Agents and Chemotherapy. 36 (3): 672-6. doi:10.1128/AAC.36.3.672. PMC 190578. PMID 1320365. "At gathering of HIV/ ...

https://en.wikipedia.org/wiki/Raymond_F._Schinazi

1990). "Anti-AIDS agents, 2: Inhibitory effects of tannins on HIV reverse transcriptase and HIV replication in H9 lymphocyte ... HPLC determination Tannins, including gallo and ellagic acid (epigallitannins), are inhibitors of HIV replication. 1,3,4-Tri-O- ... Two compounds, punicalin and punicacortein C, inhibited purified HIV reverse transcriptase. Hydrolysable tannins have shown ... galloylquinic acid, 3,5-di-O-galloyl-shikimic acid, 3,4,5-tri-O-galloylshikimic acid, punicalin, punicalagin inhibited HIV ...

https://en.wikipedia.org/wiki/Hydrolysable_tannin

... a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults". Antimicrobial Agents and Chemotherapy. 42 (9 ... For HIV-1 infection, tenofovir is indicated in combination with other antiretroviral agents for people 2 years of age and older ... In 1997 researchers from Gilead and the University of California, San Francisco demonstrated that tenofovir exhibits anti-HIV ... It does not cure HIV/AIDS or hepatitis B. It is available by mouth as a tablet or powder. Common side effects include nausea, ...

https://en.wikipedia.org/wiki/Tenofovir_disoproxil

Two years later the etiology agent for AIDS, the HIV was described. HIV is a retrovirus and has two major serotypes, HIV-1 and ... De Clercq E (April 2009). "Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV". International ... The perfect anti-HIV drug chemical should be effective against drug resistance mutation. Understanding the target RT enzyme and ... Bal TR, Anand B, Yogeeswari P, Sriram D (October 2005). "Synthesis and evaluation of anti-HIV activity of isatin beta- ...

https://en.wikipedia.org/wiki/Discovery_and_development_of_non-nucleoside_reverse-transcriptase_inhibitors

Other agents that have been proposed to target polyomavirus BK, such as cidofovir, fluoroquinolones, leflunomide, and statins ... For example, in severely immunocompromised HIV-patients, previously called AIDS-patients, immunologic function can be restored ... by treatment with highly active anti-retroviral therapy. In kidney transplant recipients who are treated with immunosuppressive ... Also, some of these agents may cause severe long-lasting side effects.[citation needed] Huang, Gang; Chen, Li-Zhong; Qiu, Jiang ...

https://en.wikipedia.org/wiki/Decoy_cells

A new class of potent anti-HIV agents". Tetrahedron Letters. 40 (15): 2969-2972. doi:10.1016/S0040-4039(99)00339-1.{{cite ... It exhibits anti-HIV activity in vitro. Xie FG, Li CJ, Yang JZ, Luo YM, Zhang DM (2012). "[data unknown/missing]" [Study on ...

https://en.wikipedia.org/wiki/Hypoglaunine

Unfortunately, cancers treated with a variety of anti-cancer drugs can develop resistance to other cytotoxic agents. Drug ... She has worked on new drugs for the treatment of HIV, which work by blocking the action of ZMPSTE24. Hrycyna studies the post- ... "New clue for HIV drug side effects: study". Reuters. 2007-07-17. Retrieved 2019-04-04. Hrycyna, Christine. "Structure, Function ... Whilst it is understood that P-glycoproteins are important in the movement of pharmalogical agents, their mechanism as a drug ...

https://en.wikipedia.org/wiki/Christine_A._Hrycyna

The method has been applied in the combination of anti-cancer drugs, anti-HIV agents, drug-radiation, and traditional Chinese ... With colleagues, T.C. Chou is inventor/co-inventor of 40 U.S. Patents, mainly for anticancer agents. He was induced to Johns ... where Dm equals to the anti-log of the x-intercept. This unique theory holds true for all dose-effect curves that follows the ...

https://en.wikipedia.org/wiki/Ting-Chao_Chou

that inhibits HIV-1 replication in vitro. During phase II clinical trials there was some indication of a decreased mean viral ... Dexelvucitabine is a failed experimental agent for the management of human immunodeficiency virus infection. It is a cytidine ... Ryder, Neil S (2007-12-01). "Discontinued drugs in 2006: anti-infectives". Expert Opinion on Investigational Drugs. 16 (12): ... Antimicrobial Agents and Chemotherapy. 51 (6): 2130-2135. doi:10.1128/aac.01543-06. ISSN 0066-4804. PMC 1891415. PMID 17403996 ...

https://en.wikipedia.org/wiki/Dexelvucitabine

However, ingenol has been reported to encourage anti-HIV and anti-leukemia cellular activity that protects T-cells. In folk ... A 1961 study found that latex from various Euphorbia species, including E. candelabrum, is a potent tumor-promoting agent. ... Hong, Kee-Jong; Lee, Hak Sung; Kim, Yeong-Shik; Kim, Sung Soon (September 2011). "Ingenol Protects Human T Cells From HIV-1 ... malaria and HIV infections. It has the ability to be mixed with fat and applied topically to heal wounds, sores, and warts. E. ...

https://en.wikipedia.org/wiki/Euphorbia_candelabrum

They were able to show that indinavir, when used with two other anti-HIV drugs, could significantly reduce the HIV viral load. ... 97 patients were randomly assigned to one of the three groups: indinavir monotherapy, AZT and lamivudine, or all three agents. ... Indinavir does not cure HIV/AIDS, but it can extend the length of a person's life for several years by slowing the progression ... Consequently, HIV viruses cannot reproduce, causing a decrease in the viral load. Commercially sold indinavir is indinavir ...

https://en.wikipedia.org/wiki/Indinavir

... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P. Q. R. S. T. U. V. W. X ... HIV in the WHO African Region Progress towards achieving Universal Access to priority health sector interventions: 2013 UPDATE ... Male circumcision for HIV prevention - implementing the 2017-2021 framework for voluntary medical male circumcision 27 February ...

https://apps.who.int:80/iris/handle/10665/1638/browse?authority=Anti-HIV+Agents&type=mesh

https://apps.who.int/iris/handle/10665/1638/browse?authority=Anti-HIV+Agents&type=mesh

https://extranet.who.int/iris/restricted/handle/10665/1638/browse?locale-attribute=en&type=mesh&authority=Anti-HIV+Agents

The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM ... concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 r … ... 3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. ... Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents Farmaco. 2004 Jan;59(1):33-9. doi: 10.1016/j.farmac. ...

https://pubmed.ncbi.nlm.nih.gov/14751314/

... and the International HIV/AIDS Alliance. by UNAIDS , World Health Organization , International HIV/AIDS Alliance. ... Text; Format: print Publication details: Genève : ONUSIDA, 2003Title translated: Handbook on access to HIV/AIDS-related ... by UNAIDS , World Health Organization , International HIV/AIDS Alliance.. Series: ONUSIDA collection meilleures pratiques. ... Handbook on access to HIV/AIDS-related treatment : a collection of information, tools and other resources for NGOs, CBOs ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=ccl=su%3A%7BAnti-HIV%20agents%7D&sort_by=relevance_dsc&count=20&limit=su-to:Needs%20assessment

of HIV/AIDS.. Series: Perspectives and practice in antiretroviral treatmentMaterial type: Text; Format: print Publication ... of HIV/AIDS.. Series: Traitements antirétroviraux : perspectives et réalitéMaterial type: Text; Format: print Publication ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=ccl=su%3A%7BAnti-HIV%20agents%7D&sort_by=relevance_dsc&count=20&limit=au:Schwartl%C3%A0nder,%20Bernhard

Founded in 2006, Affinity Biosciences is committed to providing the best quality primary antibody|secondary antibody|peptide|reagent kit|inhibitor|antibody customization|antibody query for the world, the phosphorylated antibody has become the name card of the affinity brand. - Affinity Biosciences,Cell Signal Transduction Research

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Antiviral Agents. Anti-Infective Agents. Anti-HIV Agents. Anti-Retroviral Agents. To Top ... HIV- negative test at time of enrollment (per testing algorithm). *No clinical symptoms of acute HIV infection including fever ... Proportion of men who have sex with men, female sex workers and young women at high risk of HIV enrolled into a HIV combination ... Demonstrating Effective Delivery of Daily Oral HIV Pre-Exposure Prophylaxis as Part of HIV Combination Prevention Intervention ...

https://clinicaltrials.gov/ct2/show/NCT02755350

In: AIDS: anti-HIV agents, therapies and vaccines. Ann N Y Acad Sci 1990;616:287--98. ... Antiretroviral Agents for PEP Antiretroviral agents from three classes of drugs are available for the treatment of HIV ... Panel on Clinical Practices for Treatment of HIV Infection. Guidelines for the use of antiretroviral agents in HIV-infected ... HIV p24 antigen EIA or tests for HIV RNA or HCV RNA) for routine HIV or HCV screening of source persons are not recommended. ...

http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5011a1.htm

Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected ... Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing ag ... and two thiol-based reducing agents [glutathione (GSH) and N-acetyl-L-cysteine (NAC)] against human immunodeficiency virus (HIV ... had no effect on RT concentrations and did not potentiate the anti-HIV effect of AA. These results further support the potent ...

https://pesquisa.bvsalud.org/portal/resource/pt/mdl-1720598

... excellent response to nonsteroidal anti-inflammatory agents (NSAIDS) ... Human immunodeficiency virus [HIV] (2 types occur, both with noninflammatory, sterile joint fluid) ... Staphylococcus aureus remains the most common infectious agent in people who abuse intravenous drugs. However, a high rate of ...

https://emedicine.medscape.com/article/236299-differential

HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retrovir... ... HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drug paraphernalia, and mother-to- ... This is the first agent in the new anti-HIV class called fusion inhibitors. Indicated for use in combination with other ... Antiretroviral Agent, Fusion Inhibitor. Class Summary. These agents disrupt the ability of HIV to fuse with and infect healthy ...

https://www.medscape.com/answers/211316-6887/which-medications-in-the-drug-class-cyp3a4-inhibitors-are-used-in-the-treatment-of-hiv-infection-and-aids

They do not cure HIV, but fight the infection. Learn more about these medicines. ... There are several different types of HIV medicines. ... ClinicalTrials.gov: Anti-HIV Agents (National Institutes of ... How do HIV medicines work?. HIV medicines reduce the amount of HIV (viral load) in your body, which helps by:. *Giving your ... What are HIV PrEP and PEP medicines?. HIV medicines are not just used for treatment. Some people take them to prevent HIV. PrEP ...

https://medlineplus.gov/hivaidsmedicines.html

... patients agreed to begin appropriate second-line and third-line anti-TB treatment. All anti-TB treatment regimens were ... early drug susceptibility testing for first-line and second line agents; improvement in adherence for second-line TB drugs; ... For HIV, these include more rapid HIV testing for early initiation of ART, appropriate monitoring of CD4 T-cell counts, HIV ... HIV status was not associated with a higher mortality rate or culture conversion, but among HIV-infected XDR TB patients, ...

https://wwwnc.cdc.gov/eid/article/19/3/12-0998_article

Anti-HIV Agents [‎3]‎. Anti-Retroviral Agents [‎3]‎. * * Browsing Publications by Subject * IRIS Home ...

https://extranet.who.int/iris/restricted/handle/10665/1638/browse?rpp=20&etal=-1&sort_by=-1&type=mesh&starts_with_previous=K&starts_with=A&order=ASC

... , Acute Retroviral Syndrome, Acute HIV Infection, HIV New Diagnosis, Primary HIV Infection. ... HIV related disease. *Occult infection (especially if CD4 Count, 200 cells). *Anti-microbial agents (Drug Reaction in HIV). * ... HIV Presentation. Aka: HIV Presentation, Acute Retroviral Syndrome, Acute HIV Infection, HIV New Diagnosis, Primary HIV ... Infezione acuta con HIV. Dutch. HIV-seroconversieziekte, acute infectie met HIV, Acuut HIV-infectiesyndroom, acute HIV-infectie ...

https://fpnotebook.com/legacy/HIV/Exam/HvPrsntn.htm

Public Health Service Guidelines for the Management of Health-Care Worker Exposures to HIV and Recommendations for Postexposure ... In: AIDS: anti-HIV agents, therapies and vaccines. Ann N Y Acad Sci 1990;100;616:287-98. * Tsai C-C, Follis KE, Sabo A, et al. ... Human immunodeficiency virus (HIV) postexposure prophylaxis (PEP) following occupational HIV exposure: findings from the HIV ... for reporting unusual or severe toxicity to anti- retroviral agents) CDC (for reporting HIV Telephone: (404)639-6425 ...

https://wonder.cdc.gov/wonder/prevguid/m0052722/m0052722.asp

indicating that it may have therapeutic value in the treatment of HIV Infections, Genital Herpes, and Herpes Labialis ... Anti-Bacterial Agents, Anti-Inflammatory Agents, Antihypertensive Agents, Antioxidants, Antiviral Agents, Immunomodulatory ... Pharmacological Actions : Anti-Fibrotic, Anti-Inflammatory Agents, Antioxidants, NF-kappaB Inhibitor, Renoprotective ... Pharmacological Actions : Anti-Inflammatory Agents, Anticholesteremic Agents, Hypolipidemic, NF-kappaB Inhibitor, Tumor ...

https://greenmedinfo.com/substance/prunella-vulgaris

239000002259 anti human immunodeficiency virus agent Substances 0.000 claims description 10 * 230000036436 anti-hiv Effects ... 102000000642 HIV Integrase Human genes 0.000 title description 4 * 108010002459 HIV Integrase Proteins 0.000 title description ... 239000003443 antiviral agent Substances 0.000 claims description 3 * 238000006243 chemical reaction Methods 0.000 description ... 239000007800 oxidant agent Substances 0.000 description 6 * KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances data:image/svg+xml ...

https://patents.google.com/patent/EP3187225B1/en

Anti-Infective Agents Medicine & Life Sciences 92% * HIV-1 Medicine & Life Sciences 78% ... Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment. Results: SDS (≥0.1%) was virucidal against ... Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment. Results: SDS (≥0.1%) was virucidal against ... Infectivity of HIV-1 and HIV-1 load in breast milk were determined after treatment. Results: SDS (≥0.1%) was virucidal against ...

https://pennstate.pure.elsevier.com/en/publications/inactivation-of-hiv-1-in-breast-milk-by-treatment-with-the-alkyl-

We recommend that HIV programs urgently synergize with social protection sectors and address these children with HIV testing ... This paper estimates the country burden of HIV in older children and investigates the prevalence of HIV in orphans and ... The empirical data from almost 10,000 OVC under 18 years showed 11.9% were HIV-positive, the majority of whom were between 5 ... There is a large population of children living with HIV in Ethiopia, the magnitude of which has not been previously recognized ...

https://msh.org/resources/the-missed-hiv-positive-children-of-ethiopia/

Drug therapies for these complications include anti-infective agents to treat maternal infection and prevent neonatal diseases ... antiretrovirals to reduce perinatal HIV-1 transmission from the mother to the fetus; corticosteroids to prevent fetal lung ... Oxytocin is a uterotonic agent, and it induces or augments labor. Pain is a frequent occurrence that requires drug therapy at ...

https://www.medscape.com/viewarticle/533480_1

HIV, Anti-HIV Agents/standards, Anti-HIV Agents/therapeutic use, AIDS-Related Opportunistic Infections/prevention & control, ... Seção da página Medical News Today que publica notícias sobre HIV e AIDS: medicamentos anti-retrovirais, medidas preventivas, ... It presents informations about the HIV and the transmission of leishmania and the change of the epidemiology of visceral ... AIDS-Related Opportunistic Infections, HIV, Leishmaniasis/epidemiology, Epidemiology The identification and variability of the ...

https://bvsalud.org/portal-lis/en/lis-search?q=VIH+AND+sida&filter=descriptor:AIDS-Related+Opportunistic+Infections

... or anti-PD-L2 agent.. * Known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies). ... Received prior therapy with an anti-PD-1, anti-PD-L1, ... with use of disease modifying agents, corticosteroids or ...

https://moffitt.org/clinical-trials-and-studies/clinical-trial-20419

CytoDyn Announces Positive Interim Results From Its Treatment Substitution Study in Patients With HIV - read this article along ... CytoDyn intends to continue to develop PRO 140 as a therapeutic anti-viral agent in persons infected with HIV. For more ... HIV). The Company has one of the leading mAbs under development for HIV infection, PRO 140, which is a Late Stage 2 humanized ... As only HIV patients who have R5 virus exclusively can benefit from PRO 140, each patient is required to take a DNA Trofile ...

https://www.biospace.com/article/releases/cytodyn-announces-positive-interim-results-from-its-treatment-substitution-study-in-patients-with-hiv-/

Mice treated with 120 mg/kg of geraniol for four weeks showed increased anti-oxidative defenses with no signs of liver toxicity ... Mice treated with 120 mg/kg of geraniol for 4 weeks showed increased anti-oxidati... ... Geraniol is a natural monoterpene showing anti-inflammatory, antioxidant, neuroprotective and anticancer effects. No ... Geraniol is a natural monoterpene showing anti-inflammatory, antioxidant, neuroprotective and anticancer effects. No ...

https://www.frontiersin.org/articles/10.3389/fphar.2018.00018/full

keywords = "Adolescent, Adult, Anti-HIV Agents, Atazanavir Sulfate, Australia, Europe, Female, Glomerular Filtration Rate, HIV ... AU - Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) Study ... Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) Study, Zaccarelli, M., Antinori, A., Acinapura, R. A., & DOffizi, ... Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) Study, Zaccarelli, M, Antinori, A, Acinapura, RA & DOffizi, G 2016 ...

https://moh-it.pure.elsevier.com/en/publications/cumulative-and-current-exposure-to-potentially-nephrotoxic-antire

... gene expression and antioxidant and anti-pigmentation properties using cell proliferation assay, Western blotting analysis, ... numerous researchers have suggested that EGCG could be used as an anti-HIV agent, anti-inflammatory compound, or protector from ... epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent. AIDS 2002, 16, 939-941. [Google Scholar] [CrossRef] [ ... but also as an anti-wrinkle agent.. When skin is exposed to UV, oxidative stress, or environmental pollutants, free radical and ...

https://www.mdpi.com/1422-0067/19/1/173/htm

DG03107 Anti-HIV agent. DG01656 HIV reverse transcriptase inhibitor. Transporter substrate. DG02860 SLC22A8 substrate. ... DG03107 Anti-HIV agent. D01199 Emtricitabine. Antimicrobials [BR:br08307]. Antivirals. Genome replication inhibitor. HIV ... DG03107 Anti-HIV agent. DG01656 HIV reverse transcriptase inhibitor. D01199 Emtricitabine. Transporter substrate. DG02860 ... Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI). Emtricitabine. D01199 Emtricitabine (JAN/ ...

https://www.kegg.jp/entry/D01199

Handbook on access to HIV/AIDS-related treatment : a collection of information, tools and other resources for NGOs, CBOs andPLHA groups / produced by UNAIDS, WHO, and the International HIV/AIDS Alliance. (who.int)
International HIV/AIDS Alliance. (who.int)
Without treatment, HIV can gradually destroy the immune system and advance to AIDS. (medlineplus.gov)
Not everyone with HIV develops AIDS. (medlineplus.gov)
Background: Reducing transmission of HIV-1 through breast milk is needed to help decrease the burden of pediatric HIV/AIDS in society. (elsevier.com)
Seção da página Medical News Today que publica notícias sobre HIV e AIDS: medicamentos anti-retrovirais, medidas preventivas, opções de tratamento e co-infecções, incluindo tuberculose. (bvsalud.org)
Dr. Nader Pourhassan, President and CEO, commented, "Currently, there are over 30 drugs approved for HIV/AIDS treatment, but all are believed to have common problems such as drug resistance, side effects with long-term morbidities and a requirement for daily, life-long adherence. (biospace.com)
Patients should be counseled that oral contraceptives do not protect against transmission of HIV (AIDS) and other sexually trans mitted diseases (STDs ) such as Chlamydia, genital herpes, genital warts, gonorrhea, hepatitis B, and syphilis. (nih.gov)
Brockmeyer NH, Mertins L, Goos M. Pharmacokinetic interaction of antimicrobial agents with levomethadone in drug-addicted AIDS patients. (adicciones.es)
He is a HIV/AIDS denialist [2] who believes nutritional deficiencies are the causative agents of all illnesses, and has accordingly promoted fringe, diet-based treatment regimes for curing AIDS and other illnesses. (wikipedia.org)
The objective of this study was to assess traditional, complementary, and alternative medicine (TCAM) utilization pattern among HIV/AIDS patients on antiretroviral therapy at University of Gondar Comprehensive Specialized Hospital. (hindawi.com)
TCAM utilization among HIV/AIDS patients on ART was common and different sources and types were used alongside ART, with improvement reported by most. (hindawi.com)
Patients with HIV/AIDS commonly look for some kind of alternative or complementary therapy parallel to their conventional therapy. (hindawi.com)
Different CAM modalities are taken by HIV/AIDS patients in addition to the principal ART regimen. (hindawi.com)
TM practices are commonly employed in the management of HIV/AIDS and HIV related illnesses in Ethiopia either using plant medicines or faith healing. (hindawi.com)
Despite the observed widespread use of TCAM in the management of HIV/AIDS in Ethiopia, studies documenting this practice among patients on ART are almost nonexistent based on the literature review done. (hindawi.com)
While patients on anti-retroviral therapy (ART) won't develop full-blown AIDS, lurking HIV can lead to more insidious effects such as accelerated aging, heart attacks or diabetes that start earlier in life than people without HIV and other inflammatory dysfunctions. (ucsf.edu)
The Foundation for AIDS Research (amfAR) is funding an ambitious effort based in San Francisco to eliminate HIV from those who are infected. (ucsf.edu)
The Foundation for AIDS Research's (amfAR) $20 million grant to seek a cure for HIV aims to accomplish four broad goals: chart, understand, record and eradicate elusive reservoirs of HIV-harboring T cells. (ucsf.edu)
Current HIV-AIDS treatments center on antiretroviral drugs that, when taken in combination for all of a patient's life, can prevent the growth of the virus but not kill or cure it. (sciencecodex.com)
The HIV-AIDS pandemic persists. (sciencecodex.com)
They integrated university-, government-, and industry-based researchers from the United States and Canada in a combined effort to define the testable prospects of this novel treatment strategy for HIV-AIDS. (sciencecodex.com)
According to the Joint United Nations Program on HIV/AIDS (UNAIDS) report, around 30.8 million adults and 3.4 million children were living with HIV at the end of 2010. (scirp.org)
The primary goal of Highly Active Anti-Retroviral Therapy (HAART) is to prolong life, reduce HIV related mortality and morbidity in people living with HIV/AIDS. (scirp.org)
Eliminating HIV & AIDS in India: A roadmap to zero new HIV infections, zero discrimination & zero AIDS-related deaths. (edu.au)
Agents used to treat AIDS and/or stop the spread of the HIV infection. (bvsalud.org)
According to Dr. Dlamini, "AMR puts at risk decades of advances to control infectious diseases such as malaria, HIV/AIDS, tuberculosis, and sexually transmitted infections. (who.int)
Six infectious diseases -- pneumonia, tuberculosis, diarrheal diseases, malaria, measles and HIV/AIDS -- account for half of all premature deaths worldwide. (malaria.com)
Blood specimens are processed, stored, and shipped to the Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention. (cdc.gov)
An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
The severe immune plants is that suppression of the patients in whom it has been used deficiency that is characteristic of immune response can allow occult as an antineoplastic agent ( IARC, AIDS results from a deficiency in tumours or metastatic tumour cel s 2012b ). (who.int)
This is a qualitative study based on the testimony of directors of organizations addressing HIV/AIDS and people living with HIV/AIDS in the Dominican Republic. (bvsalud.org)
Although the manifestations of stigma and discrimination related to HIV/AIDS have decreased in the Dominican Republic in comparison to past decades, ignorance and lack of supervision from government authorities foster that people with HIV do not receive adequate health services and the protection of their right to employment. (bvsalud.org)
In any effort being made to prevent the spread of HIV/AIDS it is evident that stigma and the associated discrimination are obstacles for prevention programs. (bvsalud.org)
Patients with HIV/AIDS are also at increased risk of developing Kaposi sarcoma. (bvsalud.org)
The aim of this article is to present two cases of Kaposi sarcoma in the hard palate of HIV/AIDS male patients. (bvsalud.org)
Kaposi sarcoma is one of the first recognized opportunistic diseases in HIV infection and is still the most common malignancy associated with AIDS 32 . (bvsalud.org)

Effective antiretroviral therapy is the most important intervention in terms of improving longevity and preventing opportunistic infections in patients with human immunodeficiency virus (HIV) infection. (medscape.com)
The loss of these cells makes it hard for your body to fight off infections and certain HIV-related cancers. (medlineplus.gov)
Even though there is still some HIV in your body, your immune system should be strong enough to fight off infections and certain HIV-related cancers. (medlineplus.gov)
The study also notes increases in HIV-1 infections in several U.S. cities in the U.S. and worldwide. (sciencecodex.com)
At the end of 2012, an estimated 1.2 million people aged 13 and older were living with HIV infection in the United States, including 156,300 (12.8 percent) whose infections were not diagnosed, according to the Centers for Disease Control. (sciencecodex.com)
These properties can lower susceptibility to infections associated to the formation of stomach ulcers, as well as viruses like HIV. (davidwolfe.com)
Encourages diagnostic testing for monkeypox, HIV, and other sexually transmitted infections in every sexually active person for whom monkeypox is suspected. (cdc.gov)
As a result of drug resistance, antibiotics and other antimicrobial agents become ineffective, and infections become difficult or impossible to treat, increasing the risk of disease spread, severe illness, and death. (who.int)
4 It is being investigated for use in HIV-1 infections. (drugbank.com)

High mortality rates have been reported for patients co-infected with extensively drug-resistant tuberculosis (XDR-TB) and HIV, but treatment outcomes have not been reported. (cdc.gov)
It presents information on the concomitant therapy for HIV and tuberculosis with rifamycins. (bvsalud.org)
Achieving development goals for HIV, tuberculosis and malaria in sub-Saharan Africa through integrated antenatal care: barriers and challenges. (edu.au)
ADRs were high among HIV-positive patients (82.9%), mainly due to anti-tuberculosis drugs. (who.int)
M. tuberculosis kills more people than any other single infectious agent. (who.int)
Due to demographic factors, socio-economic trends, neglected tuberculosis control in many countries, and in addition, the HIV epidemic, there are many more smear-positive pulmonary tuberculosis cases, often undiagnosed and/or untreated. (who.int)
Implementing Collaborative TB-HIV Activities: A Programmatic Guide, from the International Union Against Tuberculosis and Lung Disease. (cdc.gov)
HIV), tuberculosis and syphilis (REIS et al. (bvsalud.org)

The objectives of the study were to determine the AMR patterns of Neisseria gonorrhoeae clinical isolates to antimicrobial agents in patients with HIV or high risk of HIV acquisition, to compare the concordance of disk diffusion and agar dilution as methods for determining AMR to N. gonorrhoeae, and to describe methodological challenges to carrying out AMR testing. (cam.ac.uk)
So, just like with virtually all antimicrobial agents, resistance developed to these same second-line drugs. (cdc.gov)
In this capacity, he coordinated agency efforts that addressed emerging resistance to antimicrobial agents. (cdc.gov)
Dr. Bell is also a clinical assistant professor of pediatric infectious diseases at Emory University School of Medicine, co-chairs the U.S. Federal Interagency Task Force on Antimicrobial Resistance, and is a member of the U.S. Food and Drug Administration's Anti-Infective Drug Advisory Committee, and the American Veterinary Medical Association's Committee on Antimicrobial Resistance. (cdc.gov)
AMR (Anti-Microbial Resistance) occurs when bacteria, viruses, fungi, and parasites no longer respond to antimicrobial agents. (who.int)
Program and abstracts of the 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA . Washington, DC: American Society for Microbiology, 2002. (nursingcenter.com)

Daily oral PrEP will be delivered to men who have sex with men (MSM), female sex workers (FSWs) and young women (YW) as part of a defined package of HIV combination prevention intervention for 12 months in 5 sites in Kenya. (clinicaltrials.gov)
The actual cost of delivering HIV combination prevention which includes PrEP will also be assessed and cost effectiveness modeled. (clinicaltrials.gov)
5 sites (2 government and 3 non-governmental) have been purposively selected for the demonstration because they serve high risk populations, have existing HIV prevention services and have adequate cohort of HIV negative clients who are potential candidates for PrEP. (clinicaltrials.gov)
HIV prevention packages, provider training, quality management and service delivery guidelines and standard operating guidelines will be developed. (clinicaltrials.gov)
Introduction: Pre-exposure prophylaxis (PrEP) is an evolving new approach to prevention of sexually transmitted HIV-1 that employs antiretroviral (ARV) agents prior to potential HIV-1 exposure in an attempt to reduce the likelihood of HIV-1 infection postexposure. (semanticscholar.org)
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. (semanticscholar.org)
A longitudinal cohort study of HIV 'treatment as prevention' in gay, bisexual and other men who have sex with men: the Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) study protocol. (edu.au)
Allocative and implementation efficiency in HIV prevention and treatment for people who inject drugs. (edu.au)
A 'test and treat' prevention strategy in Australia requires innovative HIV testing models: a cohort study of repeat testing among 'high-risk' men who have sex with men. (edu.au)
Working Together with Businesses: Guidance on TB and TB/HIV Prevention, Diagnosis, Treatment and Care in the Workplace, from the World Health Organization, UNAIDS, and the International Labour Organization. (cdc.gov)

In contrast, infection fector cells or from blockage of intra- of action associated with oncogenic with certain pathogens, such as hu- cel ular pathways essential for anti- viruses, may escape immune sur- man immunodeficiency virus type 1 gen recognition or of other elements veillance in immunosuppressed indi- (HIV-1) or malaria parasites, is per- of the immune response. (who.int)
This is a new technology: no adenovirus vector vaccines for other diseases are yet widely available, though vaccines for HIV, influenza, Ebola and malaria using this platform are in clinical trials and an Ebola vaccine has been briefly deployed. (allianceforscience.org)

Staphylococcus aureus remains the most common infectious agent in people who abuse intravenous drugs. (medscape.com)
Many of the antiretroviral drugs that have been approved for HIV-infected adults and adolescents are gaining FDA approval for use in younger children. (medscape.com)
Recommendations for PEP have been modified to include a basic 4-week regimen of two drugs (zidovudine and lamivudine) for most HIV exposures and an expanded regimen that includes the addition of a protease inhibitor (indinavir or nelfinavir) for HIV exposures that pose an increased risk for transmission or where resistance to one or more of the antiretroviral agents recommended for PEP is known or suspected. (cdc.gov)
Since the provisional recommendations were released, several new antiretroviral drugs have been approved by the Food and Drug Administration (FDA), and more information is available about the use and safety of antiretroviral agents in exposed HCWs (7-10). (cdc.gov)
Active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). (moffitt.org)
FICO P TABLET is a combination of Aceclofenac and Paracetamol, which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs. (netmeds.com)
The data demonstrate that CRF63_02A6 HIV-1 isolated strains and infectious molecular clones are relevant and complementary tools for assessing efficacy of developing drugs aimed at suppressing HIV- 1, including non-nucleoside-resistant virus reverse transcriptase inhibitors. (semanticscholar.org)
Despite the absence of clinical evidences regarding some potential anti-SARS-CoV-2 drugs, preliminar information reported by researchers suggest anyhow further studies in order to evaluate the clinical effects as well as the possibility to synthesize derivatives with stronger antiretroviral properties. (thieme-connect.de)
By integrating into the genome of immune cells, known as memory T cells, HIV stays hidden as a piece of DNA in cellular reservoirs that drugs find difficult to destroy. (ucsf.edu)
The discovery raises the hope that HIV may not be able to develop resistance against this novel class of drugs," said study co-author Paul Palumbo of Dartmouth's Geisel School of Medicine. (sciencecodex.com)
Regulatory guidelines for developing new antiviral drugs for HIV focus on inhibiting viral production and avoid using agents that kill cells that are actively or latently HIV-infected. (sciencecodex.com)
That's why this group of researchers is focused on developing protocols for already approved drugs used for other medical treatments that show promise in eradicating HIV-infected cells, and on testing new combinations of those drugs for novel treatment protocols. (sciencecodex.com)
In addition, they are not only the targets of ~30% of all approved drugs but also the main coreceptors for HIV infection. (uni-ulm.de)
In Morocco, TDM is not routinely used, yet low levels of anti-TB drugs can be associated with poorer treatment outcomes.Methods: We retrospectively checked our archives for patients with active TB for whom TDM was performed during 2014. (bvsalud.org)
And since then, about 10 different classes of anti-TB drugs have been developed. (cdc.gov)
In fact, in those outbreaks, death was strongly associated with drug-resistance to the two main, first-line anti-TB drugs. (cdc.gov)
So, the new definition of XDR TB is TB that's resistant to the 2 main first-line drugs - isoniazid and rifampin - and, in addition, is resistant to the two most important groups of second-line drugs - fluoroquinolones and injectable agents. (cdc.gov)
Although nonsteroidal anti-inflammatory drugs are the traditional mainstay of therapy, data suggest that colchicine, administered at a dosage of 0.6 mg twice daily for 90 days, is more likely to prevent recurrent idiopathic pericarditis. (medscape.com)
The anti-infective drugs market will jump to $66 billion by 2013, according to a recently published report. (malaria.com)
Anti-infective drugs include: anti-viral therapeutics, antibiotics, anti-fungal agents and prophylactic treatments such as vaccines. (malaria.com)
Patients infected with the human immunodeficiency virus (HIV-1) undergo extensive therapy with antiretroviral nucleoside analog drugs, among which Zidovudine (AZT) is used the most frequently. (cdc.gov)
According to the indictment, from at least May 2011 until February 2019, Lee wrote prescriptions for Serostim to HIV patients, who obtained the drugs and used their Medicare Part D benefits to pay for the drugs. (lawfuel.com)
8. Previous administration of any antiretroviral drugs (e.g., antiretroviral drugs for HIV, HBV, or HCV) within 7 days before randomization. (who.int)
Prophylactic anti-epileptic drugs (AEDs) were initiated in 44 (79%) patients. (who.int)
5,6] therapeutic anti-epileptic drugs (AEDs) use within the PICU. (who.int)
Anticholinergic agents may potentially alter the absorption of some concomitantly administered drugs due to effects of gastrointestinal motility. (nih.gov)

The Lancet HIV , 6 (8), e552-e558. (elsevier.com)

These results further support the potent antiviral activity of ascorbate and suggest its therapeutic value in controlling HIV infection in combination with thiols . (bvsalud.org)
Major aim of the Institute of Molecular Virology, headed by Jan Münch and Frank Kirchhoff, is achieving a better understanding of the molecular properties of HIV-1 and other pathogenic viruses with the ultimate aim to improve preventive and therapeutic strategies. (uni-ulm.de)
Poxviruses are currently being developed as vaccine vectors and cancer therapeutic agents. (researchgate.net)
as vaccine vectors and cancer therapeutic agents. (researchgate.net)

The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs). (nih.gov)
Attachment inhibitors bind to a specific protein on the outer surface of HIV. (medlineplus.gov)
The aim of this study was to screen a number of relevant polyphenols to develop a rational approach for designing PAP 248-286 aggregation inhibitors as potential anti-HIV agents. (simulations-plus.com)
Some arylpyridodiazepine and thidiazepine derivatives are highly selective HIV-1 inhibitors [ 13 ]. (ijpsonline.com)
However, limited evidence exists for other clinically approved anti-retroviral protease inhibitors that may bind more efficiently to Mpro from SARS-CoV-2 and block its replication. (openaire.eu)

Ca-ascorbate reduced extracellular HIV reverse transcriptase (RT) activity by about the same magnitude as the equivalent dose of AA. (bvsalud.org)
Increasing Prevalence of Synonymous Mutations K65K and K66K in HIV-1 subtype B reverse transcriptase. (edu.au)

Qualilife diagnostic operates under the medical guidance of Dr. Roopa Viswanathan, who is responsible for study interpretations in accordance to the current CLSI, IDSA and BSAC guidelines for diagnosis of infectious diseases and anti-microbial testing. (qualilifediagnostics.com)
At Qualilife Diagnostics, a state- of- the- art centre has been developed which caters not only to the diagnosis of culprit infectious agent, but also suggests the appropriate patient management option. (qualilifediagnostics.com)

In addition, this report outlines several special circumstances (e.g., delayed exposure report, unknown source person, pregnancy in the exposed person, resistance of the source virus to antiretroviral agents, or toxicity of the PEP regimen) when consultation with local experts and/or the National Clinicians' Post-Exposure Prophylaxis Hotline ([PEPline] 1-888-448-4911) is advised. (cdc.gov)
The U.S. Public Health Service (PHS) has published previous guidelines for the management of HIV exposures that included considerations for postexposure prophylaxis (PEP) ( 3 -- 5 ). (cdc.gov)
PrEP (pre-exposure prophylaxis) is for people who don't already have HIV but are at very high risk of getting it. (medlineplus.gov)
PEP (post-exposure prophylaxis) is for people who have possibly been exposed to HIV. (medlineplus.gov)
it includes recommendations for HIV postexposure prophylaxis (PEP) and discusses the scientific rationale for PEP. (cdc.gov)
The decision to recommend HIV postexposure prophylaxis must take into account the nature of the exposure (e.g., needlestick or potentially infectious fluid that comes in contact with a mucous membrane) and the amount of blood or body fluid involved in the exposure. (cdc.gov)
In January 1990, CDC issued a statement on the management of HIV exposures that included considerations for zidovudine (ZDV) use for postexposure prophylaxis (PEP) (1). (cdc.gov)
There was considerable variation in the approach to both prophylaxis and maintenance therapy of PTS in terms of choice of agent, dosage, frequency of drug monitoring and approach to subtherapeutic levels. (who.int)

At that time, data were insufficient to assess the efficacy of ZDV as a prophylactic agent in humans or the toxicity of this drug in persons not infected with HIV. (cdc.gov)

The major protease (Mpro) of SARS-CoV-2 is considered a promising target for drug interventions, based on results from related CoVs with lopinavir (LPV) an HIV protease inhibitor, that that can inhibit the Mpro of 2002 SARS-CoV. (openaire.eu)

Since publication of the 1998 HIV exposure guidelines ( 5 ), several new antiretroviral agents have been approved by the Food and Drug Administration (FDA), and more information is available about the use and safety of HIV PEP ( 6--11 ). (cdc.gov)
In addition, questions exist regarding considerations about PEP regimens when the source person's virus is known or suspected to be resistant to one or more of the antiretroviral agents that might be used for PEP. (cdc.gov)
Antiretroviral agents with long-acting properties have potential to improve treatment outcomes substantially for people living with HIV. (elsevier.com)
Inopha is supplier of Bictegravir API powder, raw material of drug to treat HIV infection in combination with other antiretroviral agents. (inopha.net)

Is currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of treatment. (mountsinai.org)
6. Allergic to the investigational agent or any components of the formulation. (who.int)
and six exclusion requirements: energetic CNS disease, leptomeningeal seeding (LMS), prior usage of docetaxel, autoimmune disease, steroid make use of above a particular dose described in the trial, and encounter with an investigational agent. (ecologicalsgardens.com)
In August 2019, Nektar Therapeutics and Bristol-Myers Squibb announced that the US FDA has granted Breakthrough Therapy Designation for investigational agent bempegaldesleukin (NKTR-214) in combination with Bristol-Myers Squibb's Opdivo® (nivolumab) for the treatment of patients with previously untreated unresectable or metastatic melanoma. (secunderabadchronicle.in)

Occupational exposures should be considered urgent medical concerns to ensure timely postexposure management and administration of HBIG, hepatitis B vaccine, and/or HIV PEP. (cdc.gov)
Since the founding of the American colonies, anti-vaccine sentiments have been widely expressed," notes Dr. Peter J. Hotez, co-director of the Texas Children's Hospital Center for Vaccine Development. (nbcnews.com)
Dr. Paul Offit, director of the Vaccine Education Center at Children's Hospital of Philadelphia, pinpoints the birth of the modern American anti-vaccine movement in 1982 with the release of the production, which he says led to a flood of lawsuits against pharmaceutical companies and advocacy groups spreading misinformation that vaccines do more harm than good. (nbcnews.com)
Medications have been discovered that slow down the HIV virus, but neither a cure or a vaccine for HIV has been discovered that worked. (tribulation101.com)
Safety and immunogenicity of a polyvalent peptide C4-V3 HIV vaccine in conjunction with IL-12. (rush.edu)
A sound rationale needed for phase III HIV-1 vaccine trials. (rush.edu)

The project will be undertaken in 3 counties of Kenya (Nairobi, Kisumu and Homa Bay) that have high HIV prevalence. (clinicaltrials.gov)
This paper estimates the country burden of HIV in older children and investigates the prevalence of HIV in orphans and vulnerable children (OVC) households. (msh.org)
After Haiti, the Dominican Republic has the highest numbers in HIV prevalence in the Caribbean and Latin American region. (bvsalud.org)
According to the demographic and health survey of 2002 carried out by ENDESA (Spanish acronym for the Demographic and Health Survey), HIV prevalence is of 1% between the ages of 15-49. (bvsalud.org)

The findings, published May 18 in the scientific journal PLOS ONE , point to development of a promising HIV treatment that could destroy the HIV DNA harbored in HIV-infected cells. (sciencecodex.com)

Antimicrob.Agents Chemother. (tocris.com)

A higher number of deaths occurred among HIV-positive patients not receiving antiretroviral therapy and among patients who did not show sputum culture conversion. (cdc.gov)

Pharmacokinetic interactions of zidovudine and methadone on intravenous drug-using patients with HIV infection. (adicciones.es)
VBDS is rare in patients with HIV infection, and only one case has been reported in the literature, that of an HIV patient with advanced disease and cytomegalovirus infection. (health.am)

Dotting the Three I's for collaborative TB-HIV activities: evaluation of a pilot programme in Kathmandu, Nepal. (edu.au)

We aimed to investigate the mechanism by which EGCG promotes skin hydration by measuring hyaluronic acid synthase ( HAS ) and hyaluronidase ( HYAL ) gene expression and antioxidant and anti-pigmentation properties using cell proliferation assay, Western blotting analysis, luciferase assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and reverse transcription polymerase chain reaction (RT-PCR) analysis. (mdpi.com)
Quantifying adaptive and innate immune responses in HIV-infected participants using a novel high throughput assay. (edu.au)
The VITROS Anti-HBs Quantitative assay is performed using the VITROS Anti-HBs Quantitative Reagent Pack and VITROS Immunodiagnostic Products Anti-HBs Calibrators on the VITROS ECi/ECiQ Immunodiagnostic System. (cdc.gov)
CDC guidelines recommend testing for HIV infection with a US Food and Drug Administration (FDA)-approved antigen/antibody immunoassay that detects HIV-1 and HIV-2 antibodies and the HIV-1 p24 antigen, with supplemental testing after a reactive assay result to differentiate between HIV-1 and HIV-2 antibodies. (medscape.com)

Known history of Human Immunodeficiency Virus (HIV) (HIV 1/2 antibodies). (moffitt.org)
If supplemental testing for HIV-1/HIV-2 antibodies shows nonreactive or indeterminant results (or if acute HIV infection or recent exposure is suspected or reported), an HIV-1 nucleic acid test is recommended to differentiate acute HIV-1 infection from a false-positive test result. (medscape.com)
Zhai Y, Zhong Z, Zariffard M, Spear GT, Qiao L. Bovine papillomavirus-like particles presenting conserved epitopes from membrane-proximal external region of HIV-1 gp41 induced mucosal and systemic antibodies. (rush.edu)

It has been studied and shown to possess antiviral activity against HIV, CMV, RSV, H1N1 and SARS-CoV . (dadamo.com)
In addition, acetylcysteine has inhibited viral stimulation by reactive oxygen intermediates, thereby producing antiviral activity in HIV patients. (wellnesscenter.net)

Nowhere is this threat more pressing than in South Africa, where drug-resistant TB and HIV have converged in a deadly syndemic defined by increased incidences of TB and HIV ( 4 ), endemic transmission of drug-resistant TB strains ( 5 ), high mortality rates ( 6 ), and poor treatment outcomes ( 7 ). (cdc.gov)
Frequency and Env determinants of HIV-1 subtype C strains from antiretroviral therapy-naive subjects that display incomplete inhibition by maraviroc. (edu.au)
TMC-310911 has shown marked activity against a variety of HIV-1 strains, including multi-PI-resistant strains, and may be less likely to generate resistance, making it a potentially desirable therapy for both treatment-naive and PI-experienced patients. (drugbank.com)

BACKGROUND: Whether or not the association between some antiretrovirals used in HIV infection and chronic kidney disease is cumulative is a controversial topic, especially in patients with initially normal renal function. (elsevier.com)
Therefore, VBDS should be considered in all HIV patients with chronic cholestasis, especially those with a history of nevirapine use. (health.am)

As elsewhere, due to scarcity of data and limited awareness of HIV infection, especially in older children, the HIV epidemic among Ethiopian children appears neglected in national programs (children ART coverage is of only 12% in 2013). (msh.org)
In response to the epidemic, tremendous efforts have been done to control the infection starting from the first HIV case. (scirp.org)
Facing the changes in the spread of the epidemic I propose some reflections on gender and HIV, and suggest how to reinforce existing positive initiatives and the adoption of new ones. (bvsalud.org)
HIV stigma and discrimination are a constant reason for pain and sadness for HIV positive people and they contribute to silence, and as a consequence, the expansion of the epidemic. (bvsalud.org)
The purpose of this paper is to present two cases of Kaposi sarcoma in its epidemic form in HIV positive patients. (bvsalud.org)

LOS ANGELES - Powered by LawFuel - A doctor who operates a medical clinic in West Hollywood where he specializes in treating HIV patients has been taken into custody pursuant to federal charges that allege he engaged in a long-running scheme to defraud health insurance companies in connection with the brand-name human growth hormone Serostim. (lawfuel.com)

BACKGROUND: Voriconazole (VRZ) is a second-generation triazole antifungal agent with broad-spectrum activity. (bvsalud.org)

It presents informations about the HIV and the transmission of leishmania and the change of the epidemiology of visceral leishmaniasis. (bvsalud.org)
Interestingly, the points anti-vaxxers made in the 1800s are not much different from points being made today," notes Elizabeth Jacobs, a professor of epidemiology and biostatistics at the University of Arizona. (nbcnews.com)
Epidemiology of HPV Genotypes among HIV Positive Women in Kenya: A Systematic Review and Meta-Analysis. (edu.au)

Resistance commonly develops when treating HIV with widely used antiretrovirals. (sciencecodex.com)
The anti-HIV effect of deferiprone persisted after the drug was stopped - "an effect quite different from all current antiretrovirals," the researchers said. (sciencecodex.com)

Despite the invention of several chemotherapeutic agents, still treatment of cancer is a major challenge, because of multi-drug resistance, toxicity or poor bioavailability. (researchsquare.com)

Immune globulin and antiviral agents (e.g., interferon with or without ribavirin) are not recommended for PEP of hepatitis C. For HCV postexposure management, the HCV status of the source and the exposed person should be determined, and for HCP exposed to an HCV positive source, follow-up HCV testing should be performed to determine if infection develops. (cdc.gov)
Although preventing blood exposures is the primary means of preventing occupationally acquired human immunodeficiency virus (HIV) infection, appropriate postexposure management is an important element of workplace safety. (cdc.gov)

In cases of HIV -associated pericarditis, appropriate antibiotics or antivirals for targeting the infection should be used. (medscape.com)
TMC-310911 is currently being investigated, in combination with other HIV therapies and antivirals, as a potential treatment for COVID-19 caused by SARS-CoV-2. (drugbank.com)

The treatment of HIV with medicines is called antiretroviral therapy (ART). (medlineplus.gov)
82 (73%) were HIV positive and 50 (61%) were receiving antiretroviral therapy. (cdc.gov)
The global epicenter of the XDR TB and HIV syndemic is KwaZulu-Natal Province in South Africa, where nearly 400 XDR TB patients, 70% co-infected with HIV, were admitted to a provincial TB referral hospital for initiation of therapy during 2003-2008 ( 9 ). (cdc.gov)
Received prior therapy with an anti-PD-1, anti-PD-L1, or anti-PD-L2 agent. (moffitt.org)
In a patient on suppressive anti-retroviral therapy, it's very hard to even find the virus. (ucsf.edu)
Given the significant cross talk between angiogenesis and the immune response, combined therapy with lenvatinib and pemrolizumab in advanced gastroesophageal cancer patient will provide improved outcomes compared to standard treatment with currently approved agents. (mountsinai.org)
She was diagnosed with HIV infection in 2000 and had not been on highly active anti-retroviral therapy (HAART) since 2003, but recently started triple drug therapy to minimize risk of vertical transmission with zidovudine, lamivudine and nevirapine 4 wk prior to presentation. (health.am)
Typically, symptoms improve within days of initiation of anti-inflammatory therapy. (medscape.com)
If chest pain persists after 2 weeks of treatment, a different agent or combination therapy should be considered. (medscape.com)
The Food and Drug Administration has approved Serostim for use only by HIV patients with wasting or cachexia who are also receiving antiretroviral therapy. (lawfuel.com)
5. With any serious infection requiring systemic anti-infective therapy within 14 days before randomization. (who.int)
A patient with impaired immune system like HIV, or one who is undergoing radiation therapy has higher chances of SJS. (targetwoman.com)
This is an open label single-arm phase II study to evaluate the combination therapy of the antibody drug conjugate, sacituzumab govitecan, and the anti-PD-L1 antibody, atezolizumab, in patients with triple negative breast cancer . (survivornet.com)
A New York Times Article says that 12 people of 75 who began combination antiretroviral therapy soon after becoming infected may have been "functionally cured" of HIV according to a French study. (tribulation101.com)
The pivotal study evaluated the combination of KEYTRUDA, Merck's anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, versus chemotherapy (treatment of physician's choice of doxorubicin or paclitaxel) for patients with advanced endometrial carcinoma following at least one prior platinum-based regimen in any setting. (merck.com)

Oral FTC-TDF provided protection against the acquisition of HIV infection among the subjects and Detectable blood levels strongly correlated with the prophylactic effect. (semanticscholar.org)

The identification of new ARV agents with potent activity against multidrug-resistant HIV remains an unmet and urgent challenge in the field of PrEP. (semanticscholar.org)

It is used to treat HIV disease. (reference.md)
This 1993 photograph depicted Dr. James Hughes (Lt), former head of the Centers for Disease Control and Prevention's (CDC) former National Center for Infectious Diseases (NCID), and Dr. William L. Roper (Rt), former Director of the CDC (1990 - 1993), presenting a CDC Achievement Award to Dr. David M. Bell, who was former Chief of what had been the HIV Information Branch. (cdc.gov)
For most patients with intact immune systems, monkeypox is a self-limited illness that does not require anti-viral treatment to clear disease. (cdc.gov)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the ongoing pandemic of 2019 CoV disease (COVID-19), which is already responsible for far more deaths than were reported during the previous public health emergencies of international concern provoked by two related pathogenic coronaviruses (CoVs) from 2002 and 2012. (openaire.eu)
HIV disease is caused by infection with HIV-1 or HIV-2, which are retroviruses in the Retroviridae family, Lentivirus genus. (medscape.com)
Around 1980's another infectious disease raised its ugly head, HIV-Human Immunodeficiency Virus! (qualilifediagnostics.com)
Development of Kaposi sarcoma in the oral cavity also has prognostic implications for untreated HIV patients, who are found to have higher death rates than patients affected only by cutaneous disease. (bvsalud.org)
Six percent of children with HIV (+) develop the disease, and 8% of seropositive women. (bvsalud.org)
Three research teams involved in the Models of Infectious Disease Agent Study, supported by NIH's National Institute of General Medical Sciences (NIGMS), responded to this need. (nih.gov)

This report updates and consolidates all previous U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and other body fluids that might contain hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
Avoiding occupational blood exposures is the primary way to prevent transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) in health-care settings ( 1 ). (cdc.gov)
To the best of the authors' knowledge, this is the first reported case of nevirapine induced cholestatic hepatitis in a patient with HIV leading to severe ductopenia and VBDS. (health.am)

To elucidate the action of vitamin C on pathogenic human retroviruses , we investigated and compared the effects of noncytoxic concentrations of ascorbic acid (AA), its calcium salt (Ca-ascorbate), and two thiol -based reducing agents [ glutathione (GSH) and N-acetyl-L-cysteine (NAC)] against human immunodeficiency virus ( HIV )-1 replication in chronically infected T lymphocytes . (bvsalud.org)

HIV stands for human immunodeficiency virus. (medlineplus.gov)
In this report, human milk was artificially infected by adding to it HIV-1 (cell-free or cell-associated) and treated with ≤1% SDS (≤10 mg /ml). (elsevier.com)
SDS was virucidal against HIV-1 in human milk and could be removed from breast milk if necessary. (elsevier.com)
VANCOUVER, Wash., July 31, 2014 (GLOBE NEWSWIRE) -- CytoDyn Inc. (OTCQB:CYDY), a biotechnology company focused on the development of new therapies for combating infection with human immunodeficiency virus (HIV), today announced positive interim results from its Phase 2b treatment substitution study. (biospace.com)
Compounds reported in our paper have shown a safety profile for human and a potential anti-SARS-CoV2 activity. (thieme-connect.de)
Treatment that targets the DNA in HIV-infected cells has been challenging because the persistent, incurable human immunodeficiency virus is able to insert its own DNA into the DNA of any infected cell while disabling that cell's ability to die to save other cells from a viral invasion. (sciencecodex.com)
Human semen is principal vehicle for transmission of HIV-1 and other enveloped viruses. (simulations-plus.com)
For example, the US Department of Health and Human Services and British HIV Association Treatment Guidelines list EFV as the preferred agent over NVP. (scirp.org)
Lee allegedly engaged in a scheme to divert Serostim - an injectable human growth hormone that is FDA-approved for HIV-positive patients - from legitimate HIV patients to other people who purchased the drug for its purported anti-aging properties. (lawfuel.com)
Lee allegedly re-sold the Serostim for a significant profit to other patients who were not HIV-positive, and who used the human growth hormone to build muscle and for other cosmetic purposes. (lawfuel.com)
Human immunodeficiency virus (HIV) is a blood-borne virus typically transmitted via sexual intercourse, shared intravenous drug paraphernalia, and during the birth process or via human milk (vertical transmission). (medscape.com)
Electron microscopy of human immunodeficiency virus (HIV)-1 virions. (medscape.com)

Pharmacokinetic variability of zidovudine in HIV-infected individuals: subgroup analysis and drug interactions. (adicciones.es)

The PHS working group decided to issue updated recommendations for the management of occupational exposure to HIV. (cdc.gov)
This report updates and consolidates the previous PHS guidelines and recommendations for occupational HBV, HCV, and HIV exposure management for HCP. (cdc.gov)
This information, along with data on ZDV efficacy in preventing perinatal transmission (3) and evidence that PEP prevented or ameliorated retroviral infection in some studies in animals (4), prompted a Public Health Service (PHS) interagency working group *, with expert consultation (5), in June 1996 to issue provisional recommendations for PEP for HCWs after occupational HIV exposure (6). (cdc.gov)
Exposure to the direct-acting DNA damaging agent bleomycin indicated that these responses were specific for the AZT exposures and not general responses to DNA damage. (cdc.gov)

Of the five patients who demonstrated a rebound in their viral load, one patient has been retested and the test results concluded the patient had a "Dual/Mixed Tropic" HIV-1 virus and should have been excluded from the study. (biospace.com)

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of primary effusion lymphoma (PEL) a rapidly progressing malignancy mostly arising in HIV-infected patients. (biotech2012.org)

from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)

This report describes treatment outcomes, adverse events, and risk factors for death among patients in South Africa with XDR TB, most of whom were co-infected with HIV. (cdc.gov)

A cohort of 2100 PrEP users (female sex workers aged 18 and above, men who have sex with men aged 18 and above, young women at high HIV risk aged 15 -29) will be followed over 12 months to assess biological and behavioral outcomes through laboratory and survey assessments. (clinicaltrials.gov)
To our knowledge there are no published reports of outcomes for patients co-infected with XDR TB and HIV at the end of TB treatment. (cdc.gov)
Her research focuses on clinical outcomes of transplantation in people living with HIV and older adults. (yale.edu)

Rifamycins and Anti-Diabetic Agents: Drug-Drug Interactions, from the Heartland National TB Center. (cdc.gov)

We have previously reported that alkyl sulfates (i.e., sodium dodecyl sulfate, SDS) are microbicidal against HIV-1 at low concentrations, are biodegradable, have little/no toxicity and are inexpensive. (elsevier.com)
Mice treated with 120 mg/kg of geraniol for 4 weeks showed increased anti-oxidative defenses with no signs of liver toxicity. (frontiersin.org)

There are four types: classic, endemic, iatrogenic and HIV-associated. (bvsalud.org)

Two sets of blood cultures and a urine culture, immunological tests, syphilis, and HIV serologies are drawn. (medpagetoday.com)
The patient was HIV positive since 2008 and was initially diagnosed with tertiary syphilis. (bvsalud.org)

Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study Day 1 or who has not recovered (i.e. (mountsinai.org)
His current role is Global Products Manager and Global Alliance Manager for Tralokinumab, an anti-IL-13 monoclonal antibody for the treatment of patients with severe asthma presently undergoing phase III clinical trials. (eurekaselect.com)

Diseases2

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Health Care1

Short course antiretroviral regimens to reduce maternal transmission of HIV.(1/7501)

HIV-associated nephropathy is a late, not early, manifestation of HIV-1 infection. (2/7501)

Clinical experience and choice of drug therapy for human immunodeficiency virus disease. (3/7501)

Issues in the treatment of active tuberculosis in human immunodeficiency virus-infected patients. (4/7501)

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (5/7501)

A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients. (6/7501)

Lack of absorption of didanosine after rectal administration in human immunodeficiency virus-infected patients. (7/7501)

Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine. (8/7501)

Heterocyclic Compounds, Bridged-Ring

HIV Infections

HIV Seropositivity

HIV Seroprevalence

HIV Seronegativity

Short course antiretroviral regimens to reduce maternal transmission of HIV.(1/7501)

HIV-associated nephropathy is a late, not early, manifestation of HIV-1 infection. (2/7501)

Clinical experience and choice of drug therapy for human immunodeficiency virus disease. (3/7501)

Issues in the treatment of active tuberculosis in human immunodeficiency virus-infected patients. (4/7501)

Inhibition of human immunodeficiency virus type 1 replication by combination of transcription inhibitor K-12 and other antiretroviral agents in acutely and chronically infected cells. (5/7501)

A multiple drug interaction study of stavudine with agents for opportunistic infections in human immunodeficiency virus-infected patients. (6/7501)

Lack of absorption of didanosine after rectal administration in human immunodeficiency virus-infected patients. (7/7501)

Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine. (8/7501)

A Study to Compare the Efficacy of Efavirenz versus Ritonavir-boosted Protease Inhibitor Based Initial Antiretroviral Therapy...

Recent Studies on Natural Products as Anti-HIV Agents: Ingenta Connect

Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1...

Browsing by Title Early antiretroviral therapy reduces the incidence of otorrhea in a randomized study of early and deferred...

Effect of class-specific therapy interruption on persistence of HIV type 1 antiretroviral resistance<...

Virological failure and development of new resistance mutations according to CD4 count at combination antiretroviral therapy...

Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and Adolescents - Full Text View -...

Atazanavir Used in Combination With Other Anti-HIV Drugs in HIV-Infected Infants, Children, and Adolescents - Full Text View -...

Higher CNS Penetration-Effectiveness of Long-term Combination Antiretroviral Therapy Is Associated With Better HIV-1 Viral...

NIH Guide: PRECLINICAL PHARMACOLOGICAL STUDIES OF ANTITUMOR AND ANTI-HIV AGENTS

Outcomes of second-line antiretroviral therapy among children living with HIV: a global cohort analysis<...

China: rapid rise in drug-resistant HIV among people not previously on treatment | Avert

Antiretroviral Combination Therapy Summary and Recommendations

Image Gallery : The Prevalence of Transmitted Antiretroviral Drug Resistance in Treatment-Naive HIV-Infected Individuals in...

What is atazanavir sulfate? | Anti-HIV Agent - Sharecare

Conference on Retroviruses and Opportunistic Infections Archives - Columbia University Medical Center

Antiretroviral treatment of adult HIV infection: 2008 Recommendations of the international AIDS society-USA panel<...

Phase III Data Show Emtricitabine Maintains Viral Load Suppression as Part of Once-Daily, Protease-Sparing Anti-HIV Regimen |...

Two-Year Clinical and Immune Outcomes in Human Immunodeficiency Virus-Infected Children Who Reconstitute CD4 T Cells Without...

Meeting Coverage - Conference on Retroviruses and Opportunistic Infections CROI 2018

Prevention of HIV-1 Infection with Early Antiretroviral Therapy | 3ie

HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal...

CROI 2015: Conference on Retroviruses and Opportunistic Infections | BC Centre for Excellence in HIV/AIDS

Five-year outcomes of initial patients treated in Botswanas National Antiretroviral Treatment Program

PPT - International AIDS Society-USA

Time trends in antiretroviral treatment use in Australia, 1997-2000 - Murdoch Research Repository

NIH initiates antiretroviral trial in pregnant women with HIV - Drug Development Technology

Approval of Fulyzaq (Crofelemer) to Relieve Symptoms of Diarrhea in HIV/AIDS Patients Taking Antiretroviral Therapy - TheBody...

北京大学医学部机构知识库([email protected]): Neamine-heterocycle conjugates as potential anti-HIV agents

Risks and benefits of structured antiretroviral drug therapy interruptions in HIV-1 infection

Choice of initial antiretroviral drugs and treatment outcomes among HIV-infected patients in sub-Saharan Africa: systematic...

Impact of etravirine on hospitalization rate between 2005 and 2011 among heavily treated HIV-1-infected individuals on failing...

Guideline on When to Start Antiretroviral Therapy and on Pre-exposure Prophylaxis for HIV. September 2015

antiretroviral arv drugs wholesalers and antiretroviral arv drugs traders

Efavirenz (Sustiva, Stocrin)

Long-term Virologic Response and Genotypic Resistance Mutations in HIV-1 Infected Kenyan Children on Combination Antiretroviral...

19th Conference on Retroviruses and Opportunistic Infections Report: prevention/PrEP, eradication, the brain, new HIV...

Brief Report: Limited Evolution of HIV Antiretroviral Drug Resistance-Associated Mutations During the Performance of Drug...

Efavirenz liquid formulation in human immunodeficiency virus-infected children<...

Metabolic and Cardiovascular Complications of Highly Active Antiretroviral Therapy for HIV Infection | Bentham Science

Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for...

Adenovirus viremia in human immunodeficiency virus-infected children. - Semantic Scholar

Renal Function Impairment and Associated Risk Factors among Human Immunodeficiency Virus Positive Individuals at Flege Hiwot...

Effect of highly active antiretroviral therapy on time to acquired immunodeficiency syndrome or death using marginal structural...

Emtricitabine/tenofovir disoproxil fumarate generic. Price of emtricitabine/tenofovir disoproxil fumarate. Uses, Dosage, Side...

Serval - Effect of antiretroviral therapy on viral load, CD4 cell count, and progression to acquired immunodeficiency syndrome...

Immune Complexes in Pediatric Human Immunodeficiency Virus Infection<...

Cervicovaginal HIV-1 shedding in women taking antiretroviral therapy in Burkina Faso: a longitudinal study<...

Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment...

Early response to highly active antiretroviral therapy in HIV-1-infected Kenyan children.

Impact of highly active antiretroviral therapy on the molecular epidemiology of newly diagnosed HIV infections

Antidepressant treatment and adherence to combination antiretroviral therapy among patients with AIDS and diagnosed depression<...

Improvement in lipoatrophy associated with highly active antiretroviral therapy in human immunodeficiency virus-infected...

Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil...

Alleles of the gene encoding IL-1?? may predict control of plasma viraemia in HIV-1 patients on highly active antiretroviral...

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Highly Active Antiretroviral Therapies Are Effective against HIV-1 Cell-to-Cell Transmission | proLékárníky.cz

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HIV capsid inhibition

Discovery and development of HIV-protease inhibitors

Cenicriviroc

Ancistrocladus korupensis

Michellamine

Surfactin