AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed Groups
Hyaline Membrane DiseaseBasement MembraneAnti-Glomerular Basement Membrane DiseaseGlomerular Basement MembraneKidney GlomerulusNephritis, HereditaryHematuriaCollagen Type IVGlomerulonephritisNephritis, InterstitialAutoantigensAutoantibodiesProteinuriaPodocytesLamininNephritisTolazolineMicroscopy, ElectronKidneyCollagenHeparitin SulfateHeparan Sulfate ProteoglycansFluorescent Antibody TechniqueGlomerulonephritis, MembranousGlomerular Filtration BarrierNephrotic SyndromeNephrosisInfant, NewbornGlomerulonephritis, MembranoproliferativeDiabetic NephropathiesImmune Complex DiseasesAntigen-Antibody ComplexGlomerular MesangiumInfant, PrematureFetal Organ MaturityCapillariesNephrosis, LipoidAnionsNegative StainingAlbuminuriaMembranesGlycosaminoglycansPuromycin AminonucleosideGlomerulosclerosis, Focal SegmentalProteoglycansCell MembraneImmunoglobulin GLupus NephritisChondroitin Sulfate ProteoglycansKidney TubulesKidney DiseasesMembrane LipidsAntibodiesRespiration, ArtificialMicroscopy, ImmunoelectronExtracellular MatrixPulmonary SurfactantsMicrobial CollagenaseComplement C3Nail-Patella SyndromeIntracellular MembranesDisease Models, AnimalImmunohistochemistryEpitheliumInfant, Premature, DiseasesFicollBiopsyMembrane PotentialsPermeabilityMembranes, ArtificialGestational AgeSerum SicknessPupil DisordersEndotheliumRats, Inbred StrainsAntigensHeparinoidsMicroscopy, Electron, TransmissionCattleLungAgrinDirofilaria immitisMembrane GlycoproteinsRespiratory Distress Syndrome, NewbornInfant, Low Birth WeightFibronectinsPlastic EmbeddingGlomerular Filtration RateDirofilariasisRabbitsPolyethyleneimineCells, CulturedEpithelial CellsSerum Albumin, BovineHexosaminesImmune SeraNeuraminic AcidsKidney CortexElectrophoresis, Polyacrylamide GelAntigen-Antibody Reactions
Hyaline Membrane Disease
A respiratory distress syndrome in newborn infants, usually premature infants with insufficient PULMONARY SURFACTANTS. The disease is characterized by the formation of a HYALINE-like membrane lining the terminal respiratory airspaces (PULMONARY ALVEOLI) and subsequent collapse of the lung (PULMONARY ATELECTASIS).
Basement Membrane
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
Anti-Glomerular Basement Membrane Disease
An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.
Glomerular Basement Membrane
The layer of EXTRACELLULAR MATRIX that lies between the ENDOTHELIUM of the glomerular capillaries and the PODOCYTES of the inner or visceral layer of the BOWMAN CAPSULE. It is the product of these two cell types. It acts as a physical barrier and an ion-selective filter.
Kidney Glomerulus
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
Nephritis, Hereditary
A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.
Hematuria
Presence of blood in the urine.
Collagen Type IV
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
Glomerulonephritis
Inflammation of the renal glomeruli (KIDNEY GLOMERULUS) that can be classified by the type of glomerular injuries including antibody deposition, complement activation, cellular proliferation, and glomerulosclerosis. These structural and functional abnormalities usually lead to HEMATURIA; PROTEINURIA; HYPERTENSION; and RENAL INSUFFICIENCY.
Nephritis, Interstitial
Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
Autoantigens
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Autoantibodies
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Proteinuria
The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
Podocytes
Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.
Laminin
Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.
Nephritis
Inflammation of any part of the KIDNEY.
Tolazoline
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
Microscopy, Electron
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Kidney
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Collagen
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Heparitin Sulfate
A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.
Heparan Sulfate Proteoglycans
Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
Fluorescent Antibody Technique
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Glomerulonephritis, Membranous
A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.
Glomerular Filtration Barrier
A specialized barrier in the kidney, consisting of the fenestrated CAPILLARY ENDOTHELIUM; GLOMERULAR BASEMENT MEMBRANE; and glomerular epithelium (PODOCYTES). The barrier prevents the filtration of PLASMA PROTEINS.
Nephrotic Syndrome
A condition characterized by severe PROTEINURIA, greater than 3.5 g/day in an average adult. The substantial loss of protein in the urine results in complications such as HYPOPROTEINEMIA; generalized EDEMA; HYPERTENSION; and HYPERLIPIDEMIAS. Diseases associated with nephrotic syndrome generally cause chronic kidney dysfunction.
Nephrosis
Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.
Infant, Newborn
An infant during the first month after birth.
Glomerulonephritis, Membranoproliferative
Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Immune Complex Diseases
Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.
Antigen-Antibody Complex
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Glomerular Mesangium
The thin membranous structure supporting the adjoining glomerular capillaries. It is composed of GLOMERULAR MESANGIAL CELLS and their EXTRACELLULAR MATRIX.
Infant, Premature
A human infant born before 37 weeks of GESTATION.
Fetal Organ Maturity
Functional competence of specific organs or body systems of the FETUS in utero.
Capillaries
The minute vessels that connect the arterioles and venules.
Nephrosis, Lipoid
A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.
Anions
Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.
Negative Staining
The technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created.
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
Membranes
Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.
Glycosaminoglycans
Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.
Puromycin Aminonucleoside
PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineoplastic properties and can cause nephrosis.
Glomerulosclerosis, Focal Segmental
A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Proteoglycans
Glycoproteins which have a very high polysaccharide content.
Cell Membrane
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Immunoglobulin G
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Lupus Nephritis
Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
Chondroitin Sulfate Proteoglycans
Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.
Kidney Tubules
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues.
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Antibodies
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Respiration, Artificial
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
Microscopy, Immunoelectron
Microscopy in which the samples are first stained immunocytochemically and then examined using an electron microscope. Immunoelectron microscopy is used extensively in diagnostic virology as part of very sensitive immunoassays.
Extracellular Matrix
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Pulmonary Surfactants
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Microbial Collagenase
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
Complement C3
A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.
Nail-Patella Syndrome
A syndrome of multiple abnormalities characterized by the absence or hypoplasia of the PATELLA and congenital nail dystrophy. It is a genetically determined autosomal dominant trait.
Intracellular Membranes
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
Disease Models, Animal
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Epithelium
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Infant, Premature, Diseases
Ficoll
A sucrose polymer of high molecular weight.
Biopsy
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Membrane Potentials
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Permeability
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Membranes, Artificial
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Gestational Age
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Serum Sickness
Immune complex disease caused by the administration of foreign serum or serum proteins and characterized by fever, lymphadenopathy, arthralgia, and urticaria. When they are complexed to protein carriers, some drugs can also cause serum sickness when they act as haptens inducing antibody responses.
Pupil Disorders
Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.
Endothelium
A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Antigens
Substances that are recognized by the immune system and induce an immune reaction.
Heparinoids
Heparin derivatives. The term has also been used more loosely to include naturally occurring and synthetic highly-sulphated polysaccharides of similar structure. Heparinoid preparations have been used for a wide range of applications including as anticoagulants and anti-inflammatories and they have been claimed to have hypolipidemic properties. (From Martindale, The Extra Pharmacopoeia, 30th, p232)
Microscopy, Electron, Transmission
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Cattle
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Lung
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Agrin
A protein component of the synaptic basal lamina. It has been shown to induce clustering of acetylcholine receptors on the surface of muscle fibers and other synaptic molecules in both synapse regeneration and development.
Dirofilaria immitis
A filarial parasite primarily of dogs but occurring also in foxes, wolves, and humans. The parasite is transmitted by mosquitoes.
Membrane Glycoproteins
Glycoproteins found on the membrane or surface of cells.
Respiratory Distress Syndrome, Newborn
A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
Infant, Low Birth Weight
An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less.
Fibronectins
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
Plastic Embedding
The infiltrating of histological specimens with plastics, including acrylic resins, epoxy resins and polyethylene glycol, for support of the tissues in preparation for sectioning with a microtome.
Glomerular Filtration Rate
The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.
Dirofilariasis
Infection with nematodes of the genus DIROFILARIA, usually in animals, especially dogs, but occasionally in man.
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Polyethyleneimine
Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Serum Albumin, Bovine
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Hexosamines
Immune Sera
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
Neuraminic Acids
Kidney Cortex
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
Electrophoresis, Polyacrylamide Gel
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Antigen-Antibody Reactions
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Erythrocyte Membrane
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Membrane Fluidity
The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Molecular Weight
The sum of the weight of all the atoms in a molecule.
Antibodies, Monoclonal
Antibodies produced by a single clone of cells.
Antibodies, Antinuclear
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Mice, Inbred C57BL
Diabetes Mellitus, Experimental
Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.
Microscopy, Fluorescence
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Fluorescent Antibody Technique, Indirect
A form of fluorescent antibody technique commonly used to detect serum antibodies and immune complexes in tissues and microorganisms in specimens from patients with infectious diseases. The technique involves formation of an antigen-antibody complex which is labeled with fluorescein-conjugated anti-immunoglobulin antibody. (From Bennington, Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
Cell Adhesion
Adherence of cells to surfaces or to other cells.
Glomerulonephritis, IGA
A chronic form of glomerulonephritis characterized by deposits of predominantly IMMUNOGLOBULIN A in the mesangial area (GLOMERULAR MESANGIUM). Deposits of COMPLEMENT C3 and IMMUNOGLOBULIN G are also often found. Clinical features may progress from asymptomatic HEMATURIA to END-STAGE KIDNEY DISEASE.
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Cell Membrane Permeability
A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.
Staining and Labeling
The marking of biological material with a dye or other reagent for the purpose of identifying and quantitating components of tissues, cells or their extracts.
Glycoproteins
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Infant, Very Low Birth Weight
An infant whose weight at birth is less than 1500 grams (3.3 lbs), regardless of gestational age.
Cerebral Hemorrhage
Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.
Lung Diseases
Pathological processes involving any part of the LUNG.
Rats, Inbred BN
Autoimmune Diseases
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Sclerosis
A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
Complement System Proteins
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Histocytochemistry
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Carbohydrates
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Antibody Specificity
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Time Factors
Elements of limited time intervals, contributing to particular results or situations.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Polysaccharide-Lyases
A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Goodpasture antigen: expression of the full-length alpha3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain. (1/267)

BACKGROUND: Tissue injury in Goodpasture (GP) syndrome (rapidly progressive glomerular nephritis and pulmonary hemorrhage) is mediated by antibasement membrane antibodies that are targeted to the alpha3(IV) chain of type IV collagen, one of five alpha(IV) chains that occur in the glomerular basement membrane. GP antibodies are known to bind epitopes within the carboxyl terminal noncollagenous domain (NC1) of the alpha3(IV) chain, termed the GP autoantigen. Whether epitopes also exist in the 1400-residue collagenous domain is unknown because studies to date have focused solely on the NC1 domain. A knowledge of GP epitopes is important for the understanding of the etiology and pathogenesis of the disease and for the development of therapeutic strategies. METHODS: A cDNA construct was prepared for the full-length human alpha3(IV) chain. The construct was stably transfected into human embryonic kidney 293 cells. The purified full-length r-alpha3(IV) chain was characterized by electrophoresis and electron microscopy. The capacity of this chain for binding of GP antibodies from five patients was compared with that of the human r-alpha3(IV)NC1 domain by competitive enzyme-linked immunosorbent assay. RESULTS: The r-alpha3(IV) chain was secreted from 293 cells as a single polypeptide chain that did not spontaneously undergo assembly into a triple-helical molecule. An analysis of GP-antibody binding to the full-length r-alpha3(IV) chain showed binding exclusively to the globular NC1 domain. CONCLUSION: The full-length human alpha3(IV) chain possesses the capacity to bind GP autoantibodies. The epitope(s) is found exclusively on the nontriple-helical NC1 domain of the alpha3(IV) chain, indicating the presence of specific immunogenic properties. The alpha3(IV) chain alone does not spontaneously undergo assembly into a triple-helical homotrimeric molecule, suggesting that coassembly with either the alpha4(IV) and/or the alpha5(IV) chain may be required for triple-helix formation.  (+info)

Identification of a clinically relevant immunodominant region of collagen IV in Goodpasture disease. (2/267)

BACKGROUND: The characteristic feature of Goodpasture disease is the occurrence of an autoantibody response to the noncollagenous domain of the alpha3 chain of type IV collagen [alpha3(IV)NC1] in the alveolar and glomerular basement membrane. These antibodies are associated with the development of a rapidly progressive glomerulonephritis, with or without lung hemorrhage, whereas autoantibodies specific for the other alpha chains of the heterotrimeric type IV collagen probably do not cause disease. In this study, we have investigated whether differences in fine specificity of autoimmune recognition of the alpha3(IV)NC1 correlate with clinical outcome. METHODS: For mapping of antibody binding to type IV collagen, chimeric collagen constructs were generated in which parts of the alpha3(IV)NC1 domain were replaced by the corresponding sequences of homologous nonreactive alpha1(IV). The different recombinant collagen chimeras allowed the analysis of antibody specificities in 77 sera from well-documented patients. RESULTS: One construct that harbors the aminoterminal third of the alpha3(IV)NC1 was recognized by all sera, indicating that it represents the dominant target of the B-cell response in Goodpasture disease. Seventy percent of the samples recognized other parts of the molecule as well. However, only reactivity to the N-terminus of the alpha3(IV)NC1 correlated with prognosis, that is, kidney survival after six months of follow-up. CONCLUSION: The results indicate the crucial importance of antibody recognition of this particular domain for the pathogenesis of Goodpasture disease, thereby opening new avenues for the development of better diagnostic and therapeutic procedures.  (+info)

Angiotensin II plays a pathogenic role in immune-mediated renal injury in mice. (3/267)

Several lines of evidence show the importance of angiotensin II (AII) in renal injuries, especially when hemodynamic abnormalities are involved. To elucidate the role of AII in immune-mediated renal injury, we studied anti-glomerular basement membrane (GBM) nephritis in AII type 1a receptor (AT1a)-deficient homozygous (AT1a-/-) and wild-type (AT1a+/+) mice. A transient activation of the renin-angiotensin system (RAS) was observed in both groups of mice at around day 1. A renal expression of monocyte chemoattractant protein-1 (MCP-1) was transiently induced at six hours in both groups, which was then downregulated at day 1. In the AT1a+/+ mice, after RAS activation, the glomerular expression of MCP-1 was exacerbated at days 7 and 14. Thereafter, severe proteinuria developed, and the renal expressions of transforming growth factor-beta1 (TGF-beta1) and collagen type I increased, resulting in severe glomerulosclerosis and interstitial fibrosis. In contrast, glomerular expression of MCP-1, proteinuria, and tissue damage were markedly ameliorated in the AT1a-/- mice. Because this amelioration is likely due to the lack of AT1a, we can conclude that AII action, mediated by AT1a, plays a pathogenic role in anti-GBM nephritis, in which AII may contribute to the exacerbation of glomerular MCP-1 expression. These results suggest the involvement of AII in immune-mediated renal injuries.  (+info)

P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation. (4/267)

P-selectin is a leukocyte adhesion receptor present in endothelial cells and platelets. We examined the role of P-selectin in the autologous phase of an accelerated model of anti-glomerular basement membrane (GBM) glomerulonephritis using P-selectin-deficient mice and chimeric mice expressing P-selectin only in platelets or endothelial cells. P-selectin-deficient mice exhibited more severe glomerular damage with increased interstitial mononuclear leukocytic infiltrates, and had significantly increased proteinuria and mortality when compared to wild-type mice. P-selectin on the endothelium was predominantly responsible for protection from the exacerbated disease, because chimeric mice with endothelial P-selectin, and not mice with platelet P-selectin, showed glomerular injury similar to that in wild-type animals. Levels of soluble circulating P-selectin were increased in nephritic wild-type mice and in chimeric mice with endothelial P-selectin, but not platelet P-selectin. Levels of soluble P-selectin, which has been shown to be anti-inflammatory in vitro, were inversely associated with the severity of disease. P-selectin was not expressed in the endothelium of the glomerulus or interstitium. Thus, the protective effect in wild-type mice may be accounted for, in part by soluble P-selectin shed by non-renal endothelial cells, although other endothelial P-selectin-dependent mechanisms cannot be ruled out.  (+info)

IL-1 up-regulates osteopontin expression in experimental crescentic glomerulonephritis in the rat. (5/267)

Osteopontin (OPN) is a macrophage chemotactic and adhesion molecule that acts to promote macrophage infiltration in rat anti-glomerular basement membrane (GBM) glomerulonephritis. The present study investigated the role of interleukin-1 (IL-1) in the up-regulation of renal OPN expression in this disease model. Accelerated anti-GBM glomerulonephritis was induced in groups of six rats. Animals were treated by a constant infusion of the IL-1 receptor antagonist or saline (control) over days -1 to 14 (induction phase) or days 7 to 21 (established disease). In normal rat kidney, OPN was expressed in a few tubules (<5%) and absent from glomeruli. During the development of rat anti-GBM disease (days 7 to 21), there was substantial up-regulation of OPN mRNA and protein expression in glomeruli (>5 cells per glomerular cross-section) and tubular epithelial cells (50-75% OPN-positive). Up-regulation of OPN expression was associated with macrophage accumulation within the kidney, severe proteinuria, loss of renal function, and severe histological damage including glomerular crescentic formation and tubulointerstitial fibrosis. In contrast, IL-1 receptor antagonist treatment of either the induction phase of disease or established disease significantly reduced OPN mRNA and protein expression in glomeruli (/75-85%, P < 0.001) and tubules (/45-60%, P < 0.001). The reduction in OPN expression was associated with significant inhibition of macrophage accumulation and progressive renal injury. In vitro, the addition of IL-1 to the normal rat tubular epithelial cell line NRK52E up-regulated OPN mRNA and protein levels, an effect that was dose-dependent and inhibited by the addition of IL-1 receptor antagonist, thus demonstrating that IL-1 can act directly to up-regulate renal OPN expression. In conclusion, this study provides in vivo and in vitro evidence that IL-1 up-regulates OPN expression in experimental kidney disease and support for the argument that inhibition of OPN expression is one mechanism by which IL-1 receptor antagonist treatment suppresses macrophage-mediated renal injury.  (+info)

Development of scarring and renal failure in a rat model of crescentic glomerulonephritis. (6/267)

BACKGROUND: The aim of this study was to develop and characterize a rat model of crescentic glomerulonephritis which progresses to glomerulosclerosis and renal failure. METHODS: Glomerulonephritis was induced in Wistar Kyoto rats by a single injection of rabbit anti-glomerular basement membrane antiserum. Albuminuria and serum creatinine were monitored. Kidneys were examined, from 2.5 h to 44 days, using light-microscopy and immunohistochemistry. To characterize the glomerular inflammatory infiltrate, glomeruli were digested to single cells and analysed by fluorescence-activated cell sorter (FACS) and by immunohistochemistry on cytospins. RESULTS: Rats developed albuminuria by 4 days and increased serum creatinine by day 18. Histology showed glomerular fibrinoid necrosis by day 4 and cellular crescents in a mean of 63% of glomeruli by day 11. By 6 weeks, rats had developed renal failure (mean creatinine >300 micromol/l) with 94% of the glomeruli showing glomerulosclerosis. The kidneys were also affected by severe interstitial nephritis and tubular loss. The glomeruli were infiltrated by monocytes/ macrophages (ED1+) and CD8+ (OX8+) cells. FACS analysis showed that CD8+ cells did not express T-cell markers (CD3, TCRalphabeta or TCRgammadelta) or the NK-cell marker (NKR-P1). FACS analysis of peripheral blood mononuclear cells demonstrated a population of monocytes reactive with OX8, and double-labelling of cytospin preparations of glomerular digests showed that a proportion of the CD8+ cells were a subset of ED1+ monocyte/macrophages. CONCLUSIONS: We have characterized a reproducible model of crescentic glomerulonephritis which rapidly progresses to chronic renal failure with glomerulosclerosis and tubulo-interstitial scarring. This model will be useful for testing new therapeutic approaches in crescentic glomerulonephritis.  (+info)

Increased susceptibility to immunologically mediated glomerulonephritis in IFN-gamma-deficient mice. (7/267)

It is postulated that IFN-gamma confers susceptibility to immunologically mediated tissue injury. To test this hypothesis, we compared the intensity of accelerated anti-glomerular basement membrane glomerulonephritis between wild-type (IFN-gamma+/+) and IFN-gamma gene knockout (IFN-gamma-/-) mice. This disease model is initiated by binding of heterologous (sheep) anti-glomerular basement membrane Abs to the glomeruli of mice preimmunized with sheep IgG. The secondary cellular and humoral immune responses to the planted Ag then lead to albuminuria and glomerular pathology. We found that IFN-gamma-/- mice or IFN-gamma+/+ mice injected with IFN-gamma-neutralizing Ab develop worse albuminuria and glomerular pathology than IFN-gamma+/+ mice. The humoral response to sheep IgG (serum mouse anti-sheep IgG titers and intraglomerular mouse IgG deposits) was comparable in the IFN-gamma+/+ and IFN-gamma-/- groups. In contrast, IFN-gamma-/- mice mounted a stronger cellular immune response (cutaneous delayed-type hypersensitivity reaction) to sheep IgG than IFN-gamma+/+ mice. These findings provide evidence that endogenous IFN-gamma has a protective role in immunologically mediated glomerulonephritis initiated by foreign Ags.  (+info)

Goodpasture disease. Characterization of a single conformational epitope as the target of pathogenic autoantibodies. (8/267)

Goodpasture disease is a prototype autoimmune disease characterized by the formation of autoantibodies against the heterotrimeric basement membrane collagen type IV, which causes a rapidly progressive glomerulonephritis. The pathogenic antibody response is directed to the non-collagenous (NC1) domain of the alpha3 chain of type IV collagen (alpha3(IV)NC1), but not to the homologous region of the alpha1(IV)NC1. To identify the conformation-dependent immunodominant epitope on the alpha3(IV)NC1, a variety of recombinant NC1 domains were constructed by replacing single residues of alpha3(IV) with the corresponding amino acids from the nonreactive alpha1(IV) chain. Replacement mutations were identified that completely destroyed the Goodpasture epitope in the alpha3(IV) chain. Based on the identification of these critical positions, the epitope was finally reconstructed within the frame of the alpha1(IV) chain. The substitution of nine discontinuous positions in the alpha1(IV)NC1 with amino acid residues from the alpha3 chain resulted in a recombinant construct that was recognized by all patients' sera (n = 20) but by none of the sera from healthy controls (n = 10). This provides, for the first time, the molecular characterization of a single immunodominant conformational epitope recognized by pathogenic autoantibodies in a human autoimmune disease, representing the basis for the development of new epitope-specific strategies in the treatment of Goodpasture disease.  (+info)

Anti-glomerular basement membrane disease superimposed on membranous nephropathy: a case report and review of the literature |...Anti-glomerular basement membrane disease superimposed on membranous nephropathy: a case report and review of the literature |...
Anti-glomerular basement membrane disease is a rare autoimmune disorder characterized by pulmonary hemorrhage, crescentic glomerulonephritis and the presence of circulating anti-glomerular basement membrane antibodies. The simultaneous occurrence of both anti-glomerular basement membrane disease and membranous nephropathy is rare. A 59-year-old Hispanic man presented with acute onset of nausea and vomiting and was found to have renal insufficiency. Work-up included a kidney biopsy, which revealed anti-glomerular basement membrane disease with underlying membranous nephropathy. He was treated with emergent hemodialysis, intravenous corticosteroids, plasmapheresis, and cyclophosphamide without improvement in his renal function. Simultaneous anti-glomerular basement membrane disease and membranous nephropathy is very rare. There have been 16 previous case reports in the English language literature that have been associated with a high mortality and morbidity, and a very high rate of renal failure resulting
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-4-237/tables/1
Pediatric anti-glomerular basement membrane glomerulonephritis<...
TY - JOUR. T1 - Pediatric anti-glomerular basement membrane glomerulonephritis. AU - Trivedi, V. A.. AU - Malter, J. S.. AU - Guillery, E.. PY - 1998/8/13. Y1 - 1998/8/13. UR - http://www.scopus.com/inward/record.url?scp=0031856041&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0031856041&partnerID=8YFLogxK. U2 - 10.1002/(SICI)1098-1101(1998)13:2,69::AID-JCA4,3.0.CO;2-6. DO - 10.1002/(SICI)1098-1101(1998)13:2,69::AID-JCA4,3.0.CO;2-6. M3 - Letter. C2 - 9704608. AN - SCOPUS:0031856041. VL - 13. JO - Journal of Clinical Apheresis. JF - Journal of Clinical Apheresis. SN - 0733-2459. IS - 2. ER - ...
https://utsouthwestern.pure.elsevier.com/en/publications/pediatric-anti-glomerular-basement-membrane-glomerulonephritis
Cerebral involvement in a patient with Goodpastures disease due to shortened induction therapy: a case report | Journal of...Cerebral involvement in a patient with Goodpastures disease due to shortened induction therapy: a case report | Journal of...
Goodpastures disease is a rare immunological disease with formation of pathognomonic antibodies against renal and pulmonary basement membranes. Cerebral involvement has been reported in several cases in the literature, yet the pathogenetic mechanism is not entirely clear. A 21-year-old Caucasian man with Goodpastures disease and end-stage renal disease presented with two generalized seizures after a period of mild cognitive disturbance. Blood pressure and routine laboratory tests did not exceed the patients usual values, and examination of cerebrospinal fluid was unremarkable. Cerebral magnetic resonance imaging (MRI) revealed multiple cortical and subcortical lesions on fluid-attenuated inversion recovery sequences. Since antiglomerular basement membrane antibodies were found to be positive with high titers, plasmapheresis was started. In addition, cyclophosphamide pulse therapy was given on day 13. Encephalopathy and MRI lesions disappeared during this therapy, and antiglomerular basement membrane
https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-3-120/figures/3
Circulating anti-glomerular basement membrane autoantibodies against α3(IV)NC1 undetectable by commercially available enzyme...Circulating anti-glomerular basement membrane autoantibodies against α3(IV)NC1 undetectable by commercially available enzyme...
AIM Cases with anti-glomerular basement membrane (GBM) disease have been reported with linear deposit of immunoglobulin G (IgG) along GBM, but have undetectable anti-GBM antibodies in circulation by enzyme linked immunosorbent assays (ELISA). We speculated that the structure of the antigens recognized by these antibodies may contribute to the negative results of ELISA. METHODS Sera from four patients were collected, with typical linear deposit of IgG along GBM but no anti-GBM reactivity by commercial ELISA kits. Circulating anti-GBM antibodies were detected by indirect immunofluorescence. Antigen specificity and its conformational structure was investigated by western-blot analysis, using recombinant human α1-α5(IV)NC1 and chimeric proteins E(A) and E(B) as antigens. RESULTS The presence of circulating anti-GBM antibodies were confirmed by indirect immunofluorescence with linear deposit of IgG towards cryptic epitopes along GBM on normal kidney sections. These antibodies did not recognize
https://www.semanticscholar.org/paper/Circulating-anti-glomerular-basement-membrane-auto-Jia-Qu/92aea8a60167ced685ae4d3b214315af7ed192c2
Glomerular basement membrane antibodies (anti-GBM) - ORGENTEC Autoimmunity BlogGlomerular basement membrane antibodies (anti-GBM) - ORGENTEC Autoimmunity Blog
Patients suffering from the Goodpasture syndrome develop autoantibodies that bind to a special type collagen, the so called Goodpasture antigen in the glomerular basement membrane of their kidneys that helps filter waste and extra fluid from the blood. Goodpasture syndrome can lead to rapidly progressive kidney failure along with lung disease.. The detection of these glomerular basement membrane antibodies (anti-GBM) in the sera of patients with suspected Goodpasture syndrome is the conclusive finding for the diagnosis of the disease.. A positive test for myeloperoxidase antibodies (anti-MPO) and a positive pANCA are also consistent with Goodpastures syndrome.. ...
https://autoimmunityblog.com/autoantibodies/from-g-to-p/glomerular-basement-membrane-antibodies-anti-gbm/
Mesangial IgA deposits indicate pathogenesis of anti-glomerular basement membrane disease. - PubMed - NCBIMesangial IgA deposits indicate pathogenesis of anti-glomerular basement membrane disease. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/22366925
Transforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit. - PubMed - NCBITransforming growth factor-beta production in anti-glomerular basement membrane disease in the rabbit. - PubMed - NCBI
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
https://www.ncbi.nlm.nih.gov/pubmed/1987768?dopt=Abstract
Antiglomerular basement membrane antibody mediated disease in the British Isles 1980-4. | The BMJ
Clinical and pathological data on 71 patients from throughout the British Isles who developed antiglomerular basement membrane antibody mediated nephritis in the period 1980-4 were studied. Two principle patterns of disease were recognised: young men presenting in their 20s with Goodpastures syndrome (glomerulonephritis and lung haemorrhage) and women presenting in their 60s with glomerulonephritis alone. The effect of treatment on prognosis of a total of 108 patients was also reviewed (the 71 patients plus patients seen before 1980 at Hammersmith Hospital). Treatment with prednisolone, cytotoxic drugs, and plasma exchange hastened the time to clearance of autoantibody and improved the outlook of patients who were not dependent on dialysis and those with lung haemorrhage. ...
https://www.bmj.com/content/292/6516/301
Goodpasture syndrome - WikipediaGoodpasture syndrome - Wikipedia
Goodpasture syndrome (GPS) is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure. It is thought to attack the alpha-3 subunit of type IV collagen, which has therefore been referred to as Goodpastures antigen. Goodpasture syndrome may quickly result in permanent lung and kidney damage, often leading to death. It is treated with immunosuppressant drugs such as corticosteroids and cyclophosphamide, and with plasmapheresis, in which the antibodies are removed from the blood. The disease was first described by an American pathologist Ernest Goodpasture of Vanderbilt University in 1919 and was later named in his honor. Play media The antiglomerular basement membrane (GBM) antibodies primarily attack the kidneys and lungs, although, generalized symptoms like malaise, weight loss, fatigue, fever, and chills are also common, as are joint aches and pains. 60 to 80% of those with the condition experience ...
https://en.wikipedia.org/wiki/Goodpasture_syndrome
Goodpastures syndrome • AARDAGoodpastures syndrome • AARDA
Goodpastures syndrome is a pulmonary-renal syndrome, which is a group of acute illnesses involving the kidneys and lungs. Goodpasture syndrome includes all of the following conditions:. Glomerulonephritis - inflammation of the glomeruli, which are tiny clusters of looping blood vessels in the kidneys that help filter wastes and extra water from the blood.. The presence of anti-glomerular basement membrane (GBM) antibodies; the GBM is part of the glomeruli and is composed of collagen and other proteins.. Bleeding in the lungs. ...
https://www.aarda.org/diseaseinfo/goodpastures-syndrome/
Medical Knowhow On Goodpastures Syndrome - Health Watch CenterMedical Knowhow On Goodpastures Syndrome - Health Watch Center
Your bodies have immune system and this system produces antibodies which are nothing other than proteins and they help to fight infections. However, when you are infected with Goodpastures Syndrome your body starts making antibodies that attack and damage your body. They mainly target the lining of your lungs and kidney and there is no particular reason why your antibodies begin to attack your own lungs and kidneys.. However there are some factors that are believed to trigger the disease. When you are exposed to viral lung infections, or you smoke or you are breathing in vapors from organic solvents, you stand a chance of being affected by the disease.. Caucasian people (mostly men) between ages 20 and 30 or above 60 suffer from this disease. If you have suffered from lupus erythematosus or Wegeners granulomatosis then your chance of contracting Goodpastures Syndrome is considerably more.. ...
http://healthwatchcenter.com/2014/12/medical-knowhow-on-goodpastures-syndrome/
Anti-glomerular basement membrane antibody-induced glomerulone...Anti-glomerular basement membrane antibody-induced glomerulone...
Anti-glomerular basement membrane antibody-induced glomerulonephritis with periglomerular granulomatous reaction and massive renal eosinophilic infiltration.: W
https://www.mysciencework.com/publication/show/anti-glomerular-basement-membrane-antibody-induced-glomerulonephritis-periglomerular-granulomatous-reaction-massive-ren-f9c9bd6b
Goodpasture SyndromeGoodpasture Syndrome
Goodpasture syndrome is a rare autoimmune disease that affects the lungs and kidneys. Normally, the immune system makes antibodies to fight off germs. With Goodpasture syndrome, however, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to glomerulonephritis and kidney failure.
http://healthlibrary.brighamandwomens.org/Search/85,P01478
Goodpasture Syndrome
Goodpasture syndrome is a rare autoimmune disease that affects the lungs and kidneys. Normally, the immune system makes antibodies to fight off germs. With Goodpasture syndrome, however, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to glomerulonephritis and kidney failure.
http://healthlibrary.agnesian.com/Search/85,P01478
Goodpasture SyndromeGoodpasture Syndrome
Goodpasture syndrome is a rare autoimmune disease that affects the lungs and kidneys. Normally, the immune system makes antibodies to fight off germs. With Goodpasture syndrome, however, the immune system mistakenly makes antibodies that attack the lungs and kidneys. This condition can quickly progress to glomerulonephritis and kidney failure.
http://healthlibrary.osfhealthcare.org/Library/DiseasesConditions/Adult/Kidney/85,P01478
Goodpasture disease - Symptoms, diagnosis and treatment | BMJ Best PracticeGoodpasture disease - Symptoms, diagnosis and treatment | BMJ Best Practice
Goodpasture disease is defined by the presence of autoantibodies to the alpha-3 chain of type IV collagen. It presents with rapidly progressive renal dysfunction often combined with lung hemorrhage. Simultaneous hemoptysis and renal failure (the pulmonary renal syndrome) has many causes, but wher...
https://bestpractice.bmj.com/topics/en-us/479
ORBi: Browsing ORBiORBi: Browsing ORBi
in Kidney International (1987), 31(1), 32-40. A proliferative glomerulonephritis was induced in rats pre-immunized with rabbit IgG by injecting intravenously a sub-nephrotoxic dose of rabbit anti-glomerular basement membrane (GBM) IgG (A rats). Most ... [more ▼]. A proliferative glomerulonephritis was induced in rats pre-immunized with rabbit IgG by injecting intravenously a sub-nephrotoxic dose of rabbit anti-glomerular basement membrane (GBM) IgG (A rats). Most rats (80%) developed a severe proteinuria (greater than 100 mg/24 hr) within two to five days after the injection of anti-GBM IgG. At the same time, microscopic examination of the kidneys revealed a glomerular infiltration by mononuclear phagocytes and a prominent decrease in the intensity of the colloidal iron reaction in glomeruli. A non-proliferative glomerular disease was induced in another group of rats (B rats) by intraperitoneal administration of aminonucleoside of puromycin. A marked proteinuria (greater than 100 mg/24 hr) ...
http://orbi.ulg.ac.be/browse?type=author&value=Dechenne,%20Charles%20p006178
Answer to medical mystery #172 - M.D. to beAnswer to medical mystery #172 - M.D. to be
Goodpasture syndrome (also known as anti-GBM disease) is characterized by the presence of auto-antibodies to a component of lung and kidney tissue. It is an exceptionally rare disease, which impacts approximately 1 in every million people, though it is more common in white European and Asian populations. Goodpasture syndrome most typically presents as a combinations of lung and kidney problems although it can present less frequently as an isolated issue with either organ system. A patient such as ours, who presents with both coughing and urinating blood (known as hemoptysis and hematuria respectively) should at least prompt the consideration of Goodpasture syndrome in the differential diagnosis. Other symptoms of lung or kidney disease include chest pain with cough, high blood pressure, and swelling of the legs, all of which our patient had on initial presentation. Other nonspecific findings include fever, rash, fatigue, and an enlarged liver and spleen, all of which occur in much more common ...
http://blog.timesunion.com/mdtobe/answer-to-medical-mystery-172/4618/
Treatment of anti-GBM antibody (Goodpastures) diseaseTreatment of anti-GBM antibody (Goodpastures) disease
Anti-GBM antibody disease is one of the three major forms of rapidly progressive (or crescentic) glomerulonephritis. Although some patients present with relatively mild renal insufficiency, this disorder is typically associated with severe renal inju
http://www.uptodate.com/contents/treatment-of-anti-gbm-antibody-goodpastures-disease
Wiley: Diagnostic Electron Microscopy: A Practical Guide to Interpretation and Technique - John Stirling, Alan Curry, Brian...Wiley: Diagnostic Electron Microscopy: A Practical Guide to Interpretation and Technique - John Stirling, Alan Curry, Brian...
John W. Stirling and Alan Curry. 1.1 The Role of Transmission Electron Microscopy (TEM) in Renal Diagnostics 1. 1.2 Ultrastructural Evaluation and Interpretation 2. 1.3 The Normal Glomerulus 3. 1.4 Ultrastructural Diagnostic Features 5. 1.5 Granular and Amorphous Deposits 6. 1.6 Organised Immune-Related Fibrils and Tubules 7. 1.7 Nonspecific Fibrils 11. 1.8 General and Nonspecific Inclusions and Deposits 11. 1.9 Fibrin 12. 1.10 Tubuloreticular Bodies (Tubuloreticular Inclusions) 12. 1.11 The Glomerular Basement Membrane 13. 1.12 The Mesangial Matrix 14. 1.13 Cellular Components of the Glomerulus 14. 1.14 Mesangial Cells 16. 1.15 The Capillary Lumen 16. 1.16 The Ultrastructural Pathology of the Major Glomerular Diseases 16. 1.17 Focal Segmental Glomerulosclerosis 17. 1.18 Pauci-Immune Glomerulonephritis (ANCA-Associated Glomerulonephritis) 18. 1.19 Anti-GBM Glomerulonephritis (Goodpasture Syndrome) 19. 1.20 Diseases with Structural GBM Changes 19. 1.21 Thin Basement Membrane Disease 21. 1.22 ...
http://www.wiley.com/WileyCDA/WileyTitle/productCd-1119973996,subjectCd-LSB0.html
A Case of Anti Glomerular Basement Membrane (GBM) Negative Goodpasture s Disease | OMICS InternationalA Case of Anti Glomerular Basement Membrane (GBM) Negative Goodpasture s Disease | OMICS International
Goodpastures disease is a fulminant rapidly progressive disease characterized by autoantibodies to the alpha-3 chain of type IV collagen (Goodpastures antigen). It can ..
https://www.omicsonline.org/open-access/a-case-of-anti-glomerular-basement-membrane-gbm-negative-goodpastures-disease-2161-105X.1000213.php?aid=32718
Pauci Antibody Anti-GBM Nephritis: A Case Report | OMICS InternationalPauci Antibody Anti-GBM Nephritis: A Case Report | OMICS International
Anti-glomerular basement membrane (GBM) disease is characterized by autoantibodies directed against the anti-GBM antigen, which is part of the non-collagenous domain of t..
https://www.omicsonline.org/open-access/pauci-antibody-antigbm-nephritis-a-case-report-2161-0959-1000230.php?aid=66663
Membranous Nephropathy with Crescents - AJKD BlogMembranous Nephropathy with Crescents - AJKD Blog
While membranous nephropathy (MN) is one of the most common forms of nephrotic syndrome in adults, it is rarely associated with the pathologic finding of crescents on kidney biopsy. Most reported cases are in the context of concomitant anti-neutrophil cytoplasmic antibody (ANCA) or anti-glomerular basement membrane (anti-GBM) antibody disease, or were documented prior to the…
https://ajkdblog.org/2014/06/05/membranous-nephropathy-with-crescents/
Type IV collagen - WikipediaType IV collagen - Wikipedia
The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture syndrome, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures. Goodpasture syndrome presents with nephritic syndrome and hemoptysis. Microscopic evaluation of biopsied renal tissue will reveal linear deposits of Immunoglobulin G by immunofluorescence. This is classically in young adult males. Mutations to the genes coding for collagen IV lead to Alport syndrome. This will cause thinning and splitting of the glomerular basement membrane. It will present as isolated hematuria, sensorineural hearing loss, and ocular disturbances and is passed on genetically, usually in an X-linked manner, although there are rarer autosomal forms. Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. Serum Collagen IV concentrations correlate ...
https://en.wikipedia.org/wiki/Type_IV_collagen
Browse disease by medical category - Moja klinikaBrowse disease by medical category - Moja klinika
Analgesic nephropathy:. Analgesic nephropathy is a chronic kidney disease that gradually leads to end-stage renal disease and the need for permanent dialysis or a kidney transplant.. Diabetic nephropathy:. Nephropathy is the deterioration of the kidneys. Th final stage of nephropathy is called end-stage renal disease, or ESRD.. End Stage Renal Disease (ESRD):. Renal failure refers to temporary or permanent damage to the kidneys that results in loss of normal kidney function.. Glomerulonephritis: Glomerulonephritis is a type of glomerular kidney disease in which the kidneys filters become inflamed and scarred, and slowly lose their ability to remove wastes and excess fluid from the blood to make urine.. Goodpasture syndrome:. Goodpasture syndrome is a rare, autoimmune disease that can affect the lungs and kidneys.. Hematuria (blood in the urine):. Hematuria is the presence of red blood cells (RBCs) in the urine.. Hemolytic uremic syndrome:. Hemolytic uremic syndrome is a rare condition that ...
http://mojaklinika.ba/en/bolesti_forme_lijecenja/po_disciplinama/bub/
Goodpasture Syndrome - Pulmonary Disorders - Merck Manuals Professional EditionGoodpasture Syndrome - Pulmonary Disorders - Merck Manuals Professional Edition
Goodpasture Syndrome - Pulmonary Disorders - Merck Manuals Professional EditionGoodpasture Syndrome - Pulmonary Disorders - Merck Manuals Professional Edition
Learn about the causes, symptoms, diagnosis & treatment of Diffuse Alveolar Hemorrhage and Pulmonary-Renal Syndrome from the Professional Version of the Merck Manuals.
http://www.merckmanuals.com/professional/pulmonary-disorders/diffuse-alveolar-hemorrhage-and-pulmonary-renal-syndrome/goodpasture-syndrome
What is the treatment for goodpasture syndrome? - Answered by top doctors on HealthTapWhat is the treatment for goodpasture syndrome? - Answered by top doctors on HealthTap
Dr. Bellot responded: Immunosuppression. Since the condition is produced by an abnormal immune response, the treatment is to reduce production of the |a href=/topics/antibody track_data={
https://www.healthtap.com/user_questions/155669-what-is-the-treatment-for-goodpasture-syndrome
Goodpasture Name Meaning, Family History, Family Crest & Coats of ArmsGoodpasture Name Meaning, Family History, Family Crest & Coats of Arms
View the Goodpasture surname, family crest and coat of arms. Discover the Goodpasture family history for the Dutch Origin. What is the origin of the name Goodpasture?
https://www.houseofnames.com/goodpasture-family-crest
With little hope for life-saving transplant, woman gets kidney in unique procedure | UIC TodayWith little hope for life-saving transplant, woman gets kidney in unique procedure | UIC Today
Schmidt will need to take drugs for the rest of her life to prevent organ rejection. But she no longer needs dialysis, and she left the hospital March 20 in good health to return home.. Eculizumab was used once before at UI Health two years ago to enable a kidney transplant for another patient who had high levels of antibodies. But that patients organ had come from a living donor. Schmidts transplant is the first in the U.S. to use the protocol with a deceased donors organ.. Schmidt had developed extremely high levels of circulating antibodies due to more than 20 blood transfusions she required since developing Goodpastures syndrome 14 years ago. The rare and sometimes lethal autoimmune disorder attacks the kidneys and lungs. In Schmidts case, it destroyed her kidney function, forcing her to undergo dialysis several times a week to clean wastes from her blood.. Blood transfusions had helped to flush harmful immune cells from Schmidts blood. But even though donated blood is matched by type ...
https://today.uic.edu/with-little-hope-for-life-saving-transplant-woman-gets-kidney-in-unique-procedure
What is patient involvement? - Kidney Research UKWhat is patient involvement? - Kidney Research UK
It is because of research that I am still alive. Without the work by researchers and patients collaborating over many decades to find new ways of doing things, I couldnt have been treated for Goodpastures syndrome, been kept alive on dialysis until I could receive a kidney transplant, and spent the last 12 years living my life. But the treatments are not perfect.. There is still more to do. As experts in living with kidney disease we have a huge role to play in helping research to be better, to change policy and to improve the lives of people living with kidney disease. ...
https://kidneyresearchuk.org/research/patient-involvement/what-is-patient-involvement/
Mutagenetix > Incidental...Mutagenetix > Incidental...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. ...
https://mutagenetix.utsouthwestern.edu/incidental/incidental_rec.cfm?mid=245546
Brigham Archives - Renal Fellow NetworkBrigham Archives - Renal Fellow Network
I recently presented the case of a middle-aged patient with ESRD secondary to Goodpasture syndrome. She presented with AKI 3 months after a kidney transplant. Her creatinine had normalized to 0.9mg/dl post-transplant. However, over the next few months…. ...
https://www.renalfellow.org/tag/brigham/
アブカムブログ: メンブレン抗体アレイ Membrane Antibody Arrayアブカムブログ: メンブレン抗体アレイ Membrane Antibody Array
新製品、キャンペーン、カタログ、イベントなど、最新の情報を随時更新: メンブレン抗体アレイ Membrane Antibody Array
http://www.abcam.co.jp/blog/index.cfm/2013/8/15/membrane_antibody_arrays
UIC Course Descriptions Fall 2010 | Pharmacology - PCOLUIC Course Descriptions Fall 2010 | Pharmacology - PCOL
A lecture, conference and laboratory course on human pharmacology. Drug mechanisms, toxicities and kinetics are presented as a foundation to therapeutic application. This is a College of Medicine course that does not follow the regular academic calendar. Credit is not given for PCOL 501 if the student has credit for PCOL 425. Prerequisite(s): Grade of C or better in GCLS 501 and grade of C or better in GCLS 503; or consent of the instructor ...
http://catalog.webhost.uic.edu/gcat/cat1214archive/course_descriptions/PCOL.html
KAKEN - Research Projects | The development of anti-glomerular nephritis drug (KAKENHI-PROJECT-62870094)KAKEN - Research Projects | The development of anti-glomerular nephritis drug (KAKENHI-PROJECT-62870094)
Principal Investigator：MUROTA Sei-itsu, Project Period (FY)：1987 - 1989, Research Category：Grant-in-Aid for Developmental Scientific Research, Research Field：Biological pharmacy
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62870094/
Ultimate Acoustics Acoustic Foam Edging - 2x2x24 (48 Pack) | Musicians FriendUltimate Acoustics Acoustic Foam Edging - 2x2x24 (48 Pack) | Musicians Friend
Get the guaranteed best price on Acoustic Treatments like the Ultimate Acoustics Acoustic Foam Edging - 2x2x24 (48 Pack) at Musicians Friend. Get a low price and free shipping on thousands of items.
https://www.musiciansfriend.com/accessories/ultimate-acoustics-acoustic-foam-edging--2x2x24-48-pack
Goodpasture syndrome | Definition of Goodpasture syndrome by Websters Online DictionaryGoodpasture syndrome | Definition of Goodpasture syndrome by Websters Online Dictionary
Looking for definition of Goodpasture syndrome? Goodpasture syndrome explanation. Define Goodpasture syndrome by Websters Dictionary, WordNet Lexical Database, Dictionary of Computing, Legal Dictionary, Medical Dictionary, Dream Dictionary.
http://www.webster-dictionary.org/definition/Goodpasture%20syndrome
Diffuse alveolar hemorrhage due to antibasement membrane antibody disease appearing with a polyglandular autoimmune syndrome<...
TY - JOUR. T1 - Diffuse alveolar hemorrhage due to antibasement membrane antibody disease appearing with a polyglandular autoimmune syndrome. AU - Moss, M.. AU - Neff, T. A.. AU - Colby, T. V.. AU - Schwarz, M. I.. AU - Zamora, M. R.. PY - 1994. Y1 - 1994. N2 - We describe a patient with type 3-C polyglandular autoimmune syndrome who presented with diffuse alveolar hemorrhage and normal renal function. The diagnosis of antibasement membrane antibody disease was established by immunofluorescent staining of transbronchial biopsy specimens. We suggest the incorporation of antibasement membrane antibody disease into the spectrum of diseases that define the polyglandular autoimmune syndromes.. AB - We describe a patient with type 3-C polyglandular autoimmune syndrome who presented with diffuse alveolar hemorrhage and normal renal function. The diagnosis of antibasement membrane antibody disease was established by immunofluorescent staining of transbronchial biopsy specimens. We suggest the ...
https://mayoclinic.pure.elsevier.com/en/publications/diffuse-alveolar-hemorrhage-due-to-antibasement-membrane-antibody
Serval - Alveolar hemorrhage in anti-basement membrane antibody disease: a series of 28 casesServal - Alveolar hemorrhage in anti-basement membrane antibody disease: a series of 28 cases
Anti-basement membrane antibody disease is a rare disorder characterized by the presence of autoantibodies binding to the alveolar and glomerular basement membranes, and mediating both alveolar hemorrhage and acute glomerulonephritis. We retrospectively analyzed 28 cases of anti-basement membrane antibody disease with alveolar hemorrhage proven by bronchoalveolar lavage. The median age of patients at diagnosis was 23 years; 68% were male, 89% were active smokers, and 36% were exposed to some other inhaled agent. At diagnosis, 46% had predominant pulmonary involvement with normal initial serum creatinine. Lung function tests disclosed a restrictive ventilatory defect in 28% (n = 11) and hypoxemia (moderate in 29% and severe in 29%, n = 21). Carbon monoxide transfer factor was elevated in only 25% (n = 12). Bronchoalveolar lavage was more sensitive than any other criterion for detecting alveolar hemorrhage. After onset of treatment, new hemoptysis or transient worsening of hypoxemia occu
https://serval.unil.ch/en/notice/serval:BIB_DBAF5D86F072
Goodpastures Syndrome Medical Definition | Merriam-Webster Medical DictionaryGoodpastures Syndrome Medical Definition | Merriam-Webster Medical Dictionary
Medical definition of Goodpastures syndrome: an autoimmune disorder of unknown cause that is characterized by the presence of circulating antibodies…
https://www.merriam-webster.com/medical/Goodpasture%27s%20syndrome
A solid phase immunoassay for anti-glomerular basement membrane and anti-alveolar basement membrane antibodiesA solid phase immunoassay for anti-glomerular basement membrane and anti-alveolar basement membrane antibodies
University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. ...
https://prism.ucalgary.ca/handle/1880/22310
Glomerular Basement Membrane Antibody PanelGlomerular Basement Membrane Antibody Panel
Glomerular Basement Membrane Antibody Panel,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
http://www.bio-medicine.org/medicine-products/Glomerular-Basement-Membrane-Antibody-Panel-22934-1/
Goodpasture Syndrome: Molecular Architecture and Function of Basement Membrane Antigen | SpringerLinkGoodpasture Syndrome: Molecular Architecture and Function of Basement Membrane Antigen | SpringerLink
In studies of victims from the influenza pandemic of 1918-1919, Ernest Goodpasture described the coexistence of fatal pulmonary hemorrhage and proliferative glomerulonephritis in a young man (25)....
https://link.springer.com/chapter/10.1007/978-1-4612-0485-5_9
Conjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritisConjugated Linoleic Acid in the treatment of murine autoimmune glomerulonephritis
Conjugated linoleic acid (CLA) has been shown to reduce inflammation via Peroxisome Proliferator-Activated Receptor (PPAR)-γ in inflammatory disorders such as Crohns Disease and Inflammatory Bowel Disease. We sought to determine whether CLA isomers would reduce inflammation via PPAR-γ in cultured mesangial cells, and in murine models of anti-glomerular basement membrane (anti-GBM) glomerulonephritis and Systemic Lupus Erythematosus (SLE). SV40-transformed mouse mesangial cells (MES13) were cultured with pure CLA isomers (c9,t11 or t10,c12-CLA or a 50:50 mixture prior to immune stimulation with lipopolysaccharide and interferon-γ. Next, cultured mesangial cells were transfected with small interfering RNA (siRNA) targeting PPAR-γ and treated with CLA isomers prior to immune stimulation. ELISA, qPCR, Western blot, and Griess reaction were performed to measure cytokine production, mRNA expression, induced nitric oxide synthase (iNOS) and nitrite production, respectively. Next, myeloid-specific ...
https://vtechworks.lib.vt.edu/handle/10919/77384
Fish oil slowed renal impairment in IgA nephropathy | Annals of Internal Medicine | American College of PhysiciansFish oil slowed renal impairment in IgA nephropathy | Annals of Internal Medicine | American College of Physicians
106 patients (mean age 37 y, 74% men) with biopsy-proved IgA nephropathy, a serum creatinine level ≤ 265 µmol/L, and a urinary protein excretion rate ≥ 1 g/d or a 25% increase in serum creatinine level over the preceding 6 months. Exclusion criteria were systemic lupus erythematosus, chronic liver disease, antiglomerular basement membrane glomerulonephritis, pregnancy, and lactation. 75 patients (71%) continued to receive treatment throughout the study ...
http://annals.org/aim/article-abstract/2535840/fish-oil-slowed-renal-impairment-iga-nephropathy
MEDLINE - Results of the search |page 1|
Anti-neutrophil cytoplasmatic antibody (ANCA)-associated glomerulonephritis, anti-glomerular basement membrane (GBM) glomerulonephritis and lupus nephritis are the most common causes of rapid progressive glomerulonephritis (RPGN) in the Western world. These aggressive forms of autoimmune kidney diseases significantly contribute to end-stage renal disease and are associated with high morbidity and mortality. Moreover, patients show significant heterogeneity with respect to clinical outcome and response to therapy. T cell infiltration is a morphological hallmark of RPGN and it is a critical driver of kidney injury. Different CD4 T cell subsets that are endowed with distinct regulatory and effector functions are involved in this detrimental inflammatory process. In particular, the identification and functional characterization of IL-17-expressing CD4 Th17 cells have substantially advanced our understanding of organ-specific autoimmunity. In experimental models of crescentic and proliferative GN, ...
http://bases.bireme.br/cgi-bin/wxislind.exe/iah/online/?IsisScript=iah/iah.xis&base=MEDLINE&lang=i&nextAction=lnk&isisFrom=1&count=10&exprSearch=Anti-Glomerular%20and%20Basement%20and%20Membrane%20and%20Disease
Rare, 1 in 2 Million Goodpasture Syndrome Hits Teenage Girl; Life Saved By Mom Giving Kidney to Daughter - Stanford Children...Rare, 1 in 2 Million Goodpasture Syndrome Hits Teenage Girl; Life Saved By Mom Giving Kidney to Daughter - Stanford Children...
About Stanford Childrens Health and Lucile Packard Childrens Hospital Stanford. Stanford Childrens Health, with Lucile Packard Childrens Hospital Stanford at its center, is the Bay Areas largest health care system exclusively dedicated to children and expectant mothers. As a top-ranked childrens hospital by U.S. News & World Report, we are a leader in providing world-class, nurturing care and achieving extraordinary outcomes in every pediatric and obstetric specialty. Stanford Childrens Health provides everything from specialty care to general pediatrics and can be accessed through more than 60 locations across Northern California and 100 locations in the U.S. western region. As the pediatric and obstetric teaching hospital for the world-renowned Stanford University School of Medicine, were cultivating the next generation of medical professionals and are at the forefront of scientific research to improve childrens health outcomes around the world. We are a nonprofit organization ...
http://www.stanfordchildrens.org/en/about/news/releases/2013/mom-saves-goodpasture-syndrome-daughter
Pregnancy in a Patient with Goodpasture Syndrome and Renal Transplantation | Carolina Population CenterPregnancy in a Patient with Goodpasture Syndrome and Renal Transplantation | Carolina Population Center
Since 1966, researchers at the Carolina Population Center have pioneered data collection and research techniques that move population science forward by emphasizing life course approaches, longitudinal surveys, the integration of biological measurement into social surveys, and attention to context and environment. We are also at the forefront of creating interdisciplinary training programs that integrate approaches from the social and biological sciences, building research capacity and training the next generation of scholars ...
https://www.cpc.unc.edu/resources/publications/bib/13779/
JCI - Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced...JCI - Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced...
Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that may be responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family, which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive ...
https://6jgc.com.www.mobile.jci.org/articles/view/36728/figure/2
JCI - Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced...JCI - Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced...
Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that may be responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family, which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive ...
https://www.jci.org/articles/view/36728/pdf
Regional Academy of Mantra and AstrologyRegional Academy of Mantra and Astrology
WIKI: Autoimmune diseases arise from an abnormal immune response of the body against substances and tissues normally present in the body (autoimmunity). This may be restricted to certain organs (e.g. in autoimmune thyroiditis) or involve a particular tissue in different places (e.g. Goodpastures disease which may affect the basement membrane in both the lung and the kidney). The treatment of autoimmune diseases is typically with immunosuppression--medication that decreases the immune response. A large number of autoimmune diseases are recognized. A major understanding of the underlying pathophysiology of happy autoimmune diseases has been the application of genome wide association scans that have identified a striking degree of genetic sharing among the autoimmune diseases.. This Webinar will also look into Immune-defficiency syndroms such as HIV/AIDS and into the root of auto-immune disorders.. Pricing information: Two webinars of EUR 19 € each or EUR 38 €. ...
http://www.rama-edu.com/_rama/
Glomerular Basement Membrane Antibodies, IgG, Serum - United Clinical Laboratories Test Catalog
This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturers instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements ...
http://ucl.testcatalog.org/show/GBM
Goodpastures (Anti-GBM disease)Goodpastures (Anti-GBM disease)
Pain management information for pain medicine healthcare professionals in treating and caring for their patients. Clinical Pain Advisor offers news, case studies and more.
http://www.clinicalpainadvisor.com/hospital-medicine/goodpastures-anti-gbm-disease/article/602230/
Goodpastures (Anti-GBM disease) - Renal and Urology NewsGoodpastures (Anti-GBM disease) - Renal and Urology News
Latest urology and nephrology news, research and treatment articles for urologists and nephrologists to stay updated. Clinical reviews on renal and urology treatments.
http://www.renalandurologynews.com/hospital-medicine/goodpastures-anti-gbm-disease/article/602225/
Type-IV collagen - wikidocType-IV collagen - wikidoc
Type-IV collagen is a type of collagen found primarily in the basal lamina. The C-terminus domain is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, type-IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina The alpha 3 protein constituent of type-IV collagen is thought to be the antigen implicated in goodpastures syndrome, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli. There are six human genes associated with it: ...
https://www.wikidoc.org/index.php/Type-IV_collagen
Gold Pharmacy: Viagra other prescription off!Gold Pharmacy: Viagra other prescription off!
Irradiation of the nose until the return is not considered in the peripheral zone with associated brain other viagra oedema, infarction, haemorrhage or disruption, andor the veins to the sagittal image mode. The jugulodigastric node located just below the anterior tibial vessels deep fibular nerve sural nerve and some syndromes hemihypertrophy, carolis and ehlersdanlos. Type serologic markers diseases highlights antigbm gn antigbm ab + antigbm disease incidence .Million anca goodpasture syndrome pulmonary symptoms preoperatively and treatment groups. The presence of a ct scan sensitivity and accuracy of about h, no beta emission, and a decrease table sexual potency rates. Excessive radiation to back active alternative must not miss diagnosis. Most of the abdominal inguinal ring. Studies demonstrated demyelination of the liver, within this historical background. Imaging is utilised to offset this effect. Bju int chong kt, hampson nb, corman jm. Viruses and intracellular domains, vascular ...
https://www.hsolc.org/apothecary/viagra-other/98/
Una insolita microangioite a decorso protratto: sindrome di Goodpasture estesa successivamente al miocardio.<...
TY - JOUR. T1 - Una insolita microangioite a decorso protratto. T2 - sindrome di Goodpasture estesa successivamente al miocardio.. AU - Mori, R.. AU - Corvaglia, A. G.. AU - Frustaci, A.. PY - 1992/11. Y1 - 1992/11. N2 - We describe a disease, started in a female young adult patient as an apparent pulmonary siderosis, followed nine years later by an extracapillary proliferative nephritis, which developed to uremia in a few months. Later an intra-myocardial vasculitis, responsible of heart failure, appeared. Immune-histochemistry and serological tests exclude a disease mediated by anti-GMB antibodies, and pathologic features suggest a vasculitis mainly affecting lungs and kidneys.. AB - We describe a disease, started in a female young adult patient as an apparent pulmonary siderosis, followed nine years later by an extracapillary proliferative nephritis, which developed to uremia in a few months. Later an intra-myocardial vasculitis, responsible of heart failure, appeared. Immune-histochemistry ...
https://moh-it.pure.elsevier.com/en/publications/an-unusual-chronic-microvasculitis-goodpastures-syndrome-with-lat
Measurement of intrarenal plasma flow with antiglomerular basement-membrane antibody.<...
TY - JOUR. T1 - Measurement of intrarenal plasma flow with antiglomerular basement-membrane antibody.. AU - Wallin, J. D.. AU - Rector, F. C.. AU - Seldin, D. W.. PY - 1971/12/1. Y1 - 1971/12/1. UR - http://www.scopus.com/inward/record.url?scp=0015186835&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0015186835&partnerID=8YFLogxK. M3 - Article. C2 - 4941907. AN - SCOPUS:0015186835. VL - 221. SP - 1621. EP - 1628. JO - American Journal of Physiology - Heart and Circulatory Physiology. JF - American Journal of Physiology - Heart and Circulatory Physiology. SN - 0363-6135. IS - 6. ER - ...
https://utsouthwestern.pure.elsevier.com/en/publications/measurement-of-intrarenal-plasma-flow-with-antiglomerular-basemen
anti-COL4A3 antibody | GeneTexanti-COL4A3 antibody | GeneTex
COL4A3 antibody (collagen, type IV, alpha 3 (Goodpasture antigen)) for ELISA, IHC-P, WB. Anti-COL4A3 pAb (GTX37323) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
http://www.genetex.com/Tumstatin-antibody-GTX37323.html
PCOL II EXAM II FlashcardsPCOL II EXAM II Flashcards
Inside a WBC we have a transcription factor called NFKB. In the cytosol, NFKB is normally inactivated by IKB. When a viral/bacteria protein stimulates an inflammatory response, the IKB is degraded and we have free NFKB. This translocates in the nucleus where is acts as a transcription factor, to increase cytokines, adhesion molecules, and COX-2. -Cytokines: fight pathogens but can also cause tissue damage. -Adhesion molecules: ICAM/VCAM: binds to the endothelial cells, which can then go into the tissue and fight the pathogen. -COX-2: AA is the subtrate for COX-2, which produces PGE. This causes dilation of the vessels, warmth, tenderness. ...
https://www.flashcardmachine.com/pcol-ii-examii.html
Addgene: Vector Database - pCol Ib-P9Addgene: Vector Database - pCol Ib-P9
Vector database is a digital collection of vector backbones assembled from publications and commercially available sources. This is a free resource for the scientific community that is compiled by Addgene.. This page is informational only - this vector is NOT available from Addgene - please contact the manufacturer for further details. ...
http://www.addgene.org/vector-database/2259/
Universitätsklinikum Halle(Saale): Anti-Glomeruläre Basalmembran-Antikörper (IgG)
Anti-GBM. , 7 EliA U/ml negativ 7 - 10 EliA U/ml grenzwertig , 10 EliA U/ml positiv. Quelle: PBL Flooroenzyme-Immunoassay FOR ANTI GBM ANTIBODIES Phadia GmbH 250-5514-021 ...
http://www.medizin.uni-halle.de/index.php?id=9194&L=818
Glomerular basement membraneGlomerular basement membrane
Goodpasture's syndrome is also known as anti-glomerular basement membrane disease. Capillaries become inflamed as a result of ... Glomerular basement membrane is secreted and maintained by podocyte cells. The glomular basement membrane contains three layers ... The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus. The glomerular endothelial cells, ... The glomerular basement membrane is a fusion of the endothelial cell and podocyte basal laminas, and is the main site of ...
https://en.wikipedia.org/wiki/Glomerular_basement_membrane
CyclophosphamideCyclophosphamide
Anti-glomerular Basement Membrane Antibody Disease)". StatPearls. Treasure Island, USA: StatPearls Publishing. PMID 29083697. ... Cyclophosphamide is used to treat cancers and autoimmune diseases. It is used to quickly control the disease. Due to its ... it remains an important treatment for life-threatening autoimmune diseases where disease-modifying antirheumatic drugs (DMARDs ... characterization and applicability to diverse experimental models of infectious diseases". BMC Infectious Diseases. 6 (1): 55. ...
https://en.wikipedia.org/wiki/Cyclophosphamide
Goodpasture syndromeGoodpasture syndrome
... also known as anti-glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement ... 2020). Review on anti-glomerular basement membrane disease or Goodpasture's syndrome. The Journal of Internal Medicine, 41(1), ... an initial environmental insult to the pulmonary vasculature is needed to allow the anti-glomerular basement membrane (anti-GBM ... The anti-glomerular basement membrane (GBM) antibodies primarily attack the kidneys and lungs, although, generalized symptoms ...
https://en.wikipedia.org/wiki/Goodpasture_syndrome
Rapidly progressive glomerulonephritisRapidly progressive glomerulonephritis
Serum analysis often aids in the diagnosis of a specific underlying disease. The presence of anti-glomerular basement membrane ... in the glomerular basement membrane (GBM). Some cases are associated with antibodies directed against the basement membrane of ... The majority of type I disease, however, features anti-GBM antibodies alone; these cases are considered idiopathic. ... decline in the glomerular filtration rate (GFR) within 3 months) with glomerular crescent formation seen in at least 50% or 75 ...
https://en.wikipedia.org/wiki/Rapidly_progressive_glomerulonephritis
List of MeSH codes (C12)List of MeSH codes (C12)
... anti-glomerular basement membrane disease MeSH C12.777.419.570.363.304.300 - goodpasture syndrome MeSH C12.777.419.570.363.608 ... reiter disease MeSH C12.777.809.186 - bladder calculi MeSH C12.777.809.503 - kidney calculi MeSH C12.777.809.851 - ureteral ... hartnup disease MeSH C12.777.419.815.279 - bartter syndrome MeSH C12.777.419.815.368 - cystinosis MeSH C12.777.419.815.368.210 ... kidney diseases, cystic MeSH C12.777.419.403.500 - medullary sponge kidney MeSH C12.777.419.403.750 - multicystic dysplastic ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C12)
Anti-glomerular basement membrane antibodyAnti-glomerular basement membrane antibody
Some sources consider "anti-GBM disease" and "Goodpasture disease" to be synonymous terms describing histological presentation ... glomerular basement membrane ped/117 at eMedicine antiglomerular+basement+membrane+antibody at the US National Library of ... Anti-glomerular basement membrane antibody (anti-GBM Ab) is an antibody which is found in Goodpasture's syndrome but not found ...
https://en.wikipedia.org/wiki/Anti-glomerular_basement_membrane_antibody
Alport syndromeAlport syndrome
... a disease shown to be a model for Alport syndrome. Fechtner syndrome Thin basement membrane disease "Diseases of the Kidney: ... Electron microscopy shows a characteristic sequence of changes from thinning of the glomerular basement membrane (GBM), ... "EdRen - Edinburgh Royal Infirmary Renal Unit - Alport anti-GBM disease". www.edren.org. Retrieved 2016-02-17. Tryggvason K, ... Basement membranes are thin, sheet-like structures that separate and support cells in many tissues. Type IV collagen '112' type ...
https://en.wikipedia.org/wiki/Alport_syndrome
Antinuclear antibodyAntinuclear antibody
Some anti-dsDNA antibodies are cross reactive with other antigens found on the glomerular basement membrane (GBM) of the kidney ... anti-Ro and anti-La antibodies correlate with early onset, increased disease duration, parotid gland enlargement, disease ... anti-La antibodies, anti-Sm antibodies, anti-nRNP antibodies, anti-Scl-70 antibodies, anti-dsDNA antibodies, anti-histone ... anti-Sm and anti-RNP antibodies were discovered in 1966 and 1971, respectively. In the 1970s, the anti-Ro/anti-SS-A and anti-La ...
https://en.wikipedia.org/wiki/Antinuclear_antibody
Diffuse proliferative nephritisDiffuse proliferative nephritis
... between endothelium and basement membrane). In due course, glomerular injury in DPGN gives rise to scarring (glomerulosclerosis ... Cationic deposits that cross the membrane are then deposited into sub-epithelial spaces. Then the disease advances and ... Immune-complexes are combinations of DNA, anti-dsDNA ubiquitin, and other proteins in DPGN that are associated with lupus ... This causes proteinuria by damaging the basement membrane and creating a loss of negative charge. These are anionic deposits ...
https://en.wikipedia.org/wiki/Diffuse_proliferative_nephritis
Nephritic syndromeNephritic syndrome
Antiglomerular basement membrane (anti-GBM) antibody - If positive, this is highly indicative of Goodpasture's syndrome and can ... Glomerular diseases, Syndromes affecting the kidneys). ... in the glomerular mesangium and glomerular basement membrane ... Glomerulonephritis is characterized by inflammation and thinning of the glomerular basement membrane and the occurrence of ... 50% decline in glomerular filtration rate (GFR) within 3 months) with glomerular crescent formation frequently seen on kidney ...
https://en.wikipedia.org/wiki/Nephritic_syndrome
Minimal change diseaseMinimal change disease
... immunologic response with abnormal secretion of lymphokines by T cells is thought to modify the glomerular basement membrane, ... This hypothesis is supported by recent findings of anti-nephrin antibodies isolated in minimal change disease. When albumin is ... Minimal change disease (also known as MCD, minimal change glomerulopathy, and nil disease, among others) is a disease affecting ... Due to the disease process, patients with minimal change disease are also at risk of blood clots and infections. For years, ...
https://en.wikipedia.org/wiki/Minimal_change_disease
Anti-neutrophil cytoplasmic antibodyAnti-neutrophil cytoplasmic antibody
Sinclair, D; Stevens, JM (Sep 2007). "Role of antineutrophil cytoplasmic antibodies and glomerular basement membrane antibodies ... In addition, in patients with active disease, treated with Rituximab, an anti-CD20 antibody which remove circulating B-cells, ... Although ANCA titres have been noted to have limited correlation with disease activity, except for kidney disease, and with ... Anti-neutrophil cytoplasmic antibodies (ANCAs) are a group of autoantibodies, mainly of the IgG type, against antigens in the ...
https://en.wikipedia.org/wiki/Anti-neutrophil_cytoplasmic_antibody
GlomerulonephritisGlomerulonephritis
Thin basement membrane disease is an autosomal dominant inherited disease characterized by thin glomerular basement membranes ... Anti-GBM, Complement levels, Anti-nuclear antibodies) Biopsy of the kidney Renal ultrasonography is useful for prognostic ... MGN is characterized by a thickened glomerular basement membrane without a hyperproliferation of the glomerular cells. ... In Goodpasture syndrome, IgG antibodies directed against the glomerular basement membrane trigger an inflammatory reaction, ...
https://en.wikipedia.org/wiki/Glomerulonephritis
Membranous glomerulonephritisMembranous glomerulonephritis
As the disease progresses, the deposits will eventually be cleared, leaving cavities in the basement membrane. These cavities ... The immune complexes are formed by binding of antibodies to antigens in the glomerular basement membrane. The antigens may be ... Testing for these anti-PLA2R has revolutionised diagnosis and treatment of this disease in antibody positive patients, and ... On electron microscopy, subepithelial deposits that nestle against the glomerular basement membrane seems to be the cause of ...
https://en.wikipedia.org/wiki/Membranous_glomerulonephritis
Anti-dsDNA antibodiesAnti-dsDNA antibodies
... of immune complexes that arise by indirect binding to DNA or nucleosomes that are adhered to the glomerular basement membrane ( ... Higher titres of anti-dsDNA antibodies are more suggestive of SLE and lower titres can be found in people without the disease. ... Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is ... The levels of circulating anti-dsDNA antibodies fluctuate with disease activity in SLE. Increases in titres of the antibodies ...
https://en.wikipedia.org/wiki/Anti-dsDNA_antibodies
LupusLupus
This finding is due to immune complex deposition along the glomerular basement membrane, leading to a typical granular ... which also appears in systemic sclerosis and mixed connective tissue disease), SS-A (or anti-Ro) and SS-B (or anti-La; both of ... The anti-dsDNA antibody titers also tend to reflect disease activity, although not in all cases. Other ANA that may occur in ... In the presence of autoreactive T cells, a chronic autoimmune disease may be the consequence. Anti-nRNP autoantibodies to nRNP ...
https://en.wikipedia.org/wiki/Lupus
TumstatinTumstatin
Since tumstatin is cleaved by MMP from the collagen in the basement membrane, it has been found that there are much lower ... tumstatin may have implications in treating the disease. It was found that VEGF is one of the mediators of glomerular ... Wang Shu-jing; Liu Xing-han; Ji Yu-bin; Chen Ning (6-8 July 2007). "The Effect of Tumstatin Anti-tumor Peptide on Proliferation ... Type-IV collagen is present in the basement membrane within normal lungs, and this is reduced in asthmatic patients. There are ...
https://en.wikipedia.org/wiki/Tumstatin
Ernest William GoodpastureErnest William Goodpasture
... as well as glomerular-capillary, basement membranes. After leaving Harvard in 1921, Goodpasture worked at the University of the ... Valentini, Rudolph P. Pediatric Anti-GBM Disease (Goodpasture Syndrome). Accessed 8-28-2009. Harris Riley Jr., "Ernest William ... ISBN 978-1-57736-251-7. Salama, A D; Levy J B; Lightstone L; Pusey C D (September 2001). "Goodpasture's disease". The Lancet. ... This technique made possible the development and production of a wide range of vaccines against viral diseases. Goodpasture was ...
https://en.wikipedia.org/wiki/Ernest_William_Goodpasture
Congenital nephrotic syndromeCongenital nephrotic syndrome
... which helps attach podocytes to the glomerular basement membrane. Patients with Pierson syndrome have eye abnormalities, ... Kidney diseases, Syndromes affecting the kidneys, Congenital disorders, Glomerular diseases). ... and non-steroidal anti-inflammatory drugs (like indomethacin) are used to slow the spilling of protein (albumin) in the urine. ... This disease is primarily caused by genetic mutations which result in damage to components of the glomerular filtration barrier ...
https://en.wikipedia.org/wiki/Congenital_nephrotic_syndrome
Thrombotic microangiopathyThrombotic microangiopathy
... of protein damages glomerular endothelial cells by creating voids in the endothelial wall and detaching the basement membrane ... underlying diseases (advanced HIV disease, graft-versus-host disease), and other classes of drug, particularly antifungal ... and anti-VEGF therapy. Bacterial toxins are the primary cause of one category of thrombotic microangiopathy known as HUS or ... The repression of the vascular endothelial growth factor (VEGF) can also cause glomerular TMA (damage to the glomerular ...
https://en.wikipedia.org/wiki/Thrombotic_microangiopathy
Neonatal Fc receptorNeonatal Fc receptor
January 2008). "Podocytes use FcRn to clear IgG from the glomerular basement membrane". Proceedings of the National Academy of ... Therapies seek to disrupt the IgG-FcRn interaction to increase the clearance of disease-causing IgG autoantibodies from the ... Nimmerjahn F, Ravetch JV (2008-01-01). "Anti-inflammatory actions of intravenous immunoglobulin". Annual Review of Immunology. ... Praetor A, Jones RM, Wong WL, Hunziker W (August 2002). "Membrane-anchored human FcRn can oligomerize in the absence of IgG". ...
https://en.wikipedia.org/wiki/Neonatal_Fc_receptor
PODXLPODXL
... epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other ... "Overexpression of the anti-adhesin podocalyxin is an independent predictor of breast cancer progression". Cancer Research. 64 ( ... "Expression of podocyte-associated molecules in acquired human kidney diseases". Journal of the American Society of Nephrology. ... Takeda T, McQuistan T, Orlando RA, Farquhar MG (Jul 2001). "Loss of glomerular foot processes is associated with uncoupling of ...
https://en.wikipedia.org/wiki/PODXL
HeparanaseHeparanase
van den Hoven MJ, Rops AL, Vlodavsky I, Levidiotis V, Berden JH, van der Vlag J (2007). "Heparanase in glomerular diseases". ... The enzyme degrades the heparan sulfate scaffold of the basement membrane and extracellular matrix. It is also associated with ... Heparanase has been shown to promote arterial thrombosis and stent thrombosis in mouse models due to the cleavage of anti- ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 4, Peripheral membrane proteins ...
https://en.wikipedia.org/wiki/Heparanase
Syndecan 1Syndecan 1
November 2007). "Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis". Kidney International. 72 (10): ... inflammatory bowel disease and experimental autoimmune encephalomyelitis In experimental colitis-induced colon carcinoma, ... The extracellular domain can be cleaved (shed) from the cell surface at a juxtamembrane site, converting the membrane-bound ... The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and ...
https://en.wikipedia.org/wiki/Syndecan_1
PerlecanPerlecan
Decreased perlecan in the glomerular basement membrane has a central role in the development of diabetic albuminuria. Perlecan ... It seems that there may be some overlap in diseases stemming from loss of heparan sulfate proteoglycan expression and loss of ... The theory put forward in this study is that perlecan plays an anti-proliferative role for VSMCs once a certain developmental ... which requires a pre-formed basement membrane. Collagen gels have promoted formation of a complete basement membrane by corneal ...
https://en.wikipedia.org/wiki/Perlecan
Margo CohenMargo Cohen
As a visiting scientist in England, she examined effects of diabetes on basement membranes. In Israel, Cohen discovered the ... Kennedy, Laurence; Pilar Solano, Maria; Meneghini, Luigi; Lo, Margaret; Cohen, Margo P. (2010). "Anti-glycation and anti- ... Its first FDA-approved diagnostic product was Albuwell, a test that detects diabetic kidney disease, followed by other ... October 8, 2001). "Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-bold beta1". Kidney ...
https://en.wikipedia.org/wiki/Margo_Cohen
IgA nephropathyIgA nephropathy
Other renal causes of isolated hematuria include thin basement membrane disease and Alport syndrome, the latter being a ... There are other diseases associated with glomerular IgA deposits, the most common being IgA vasculitis (formerly known as ... often with anti-platelet/anticoagulants in patients with Aggressive Berger's disease, however, the side effect profile of these ... It is the most common glomerular disease in the Far East and Southeast Asia, accounting for almost half of all the patients ...
https://en.wikipedia.org/wiki/IgA_nephropathy
Anti-glomerular basement membrane disease: MedlinePlus Medical EncyclopediaAnti-glomerular basement membrane disease: MedlinePlus Medical Encyclopedia
... anti-GBM diseases) is a rare disorder that can involve quickly worsening kidney failure and lung disease. ... Anti-glomerular basement membrane diseases (anti-GBM diseases) is a rare disorder that can involve quickly worsening kidney ... Anti-glomerular basement membrane disease and Goodpasture disease. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. ... These substances are called antiglomerular basement membrane antibodies. The glomerular basement membrane is a part of the ...
https://medlineplus.gov/ency/article/000142.htm
Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. -...Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. -...
Dive into the research topics of Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma ... Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression.. ...
https://abdn.pure.elsevier.com/en/publications/long-term-outcome-of-anti-glomerular-basement-membrane-antibody-d/fingerprints/
Acute Poststreptococcal Glomerulonephritis Workup: Approach Considerations, Hematologic and Blood Chemistry Studies, Urine...Acute Poststreptococcal Glomerulonephritis Workup: Approach Considerations, Hematologic and Blood Chemistry Studies, Urine...
It is a representative disease of acute nephritic syndrome in which inflammation of the glomerulus is manifested by ... Acute glomerulonephritis is a disease characterized by the sudden appearance of edema, hematuria, proteinuria, and hypertension ... glomerular basement membrane; C: complement; Anti-NAPlr-Ab: Anti-NAPlr-antibody. Courtesy of open access article, "The Role of ... mostly in the mesangial notch near the glomerular basement membrane reflection over mesangium. A positive correlation exists ...
https://www.medscape.com/answers/980685-87750/what-is-the-role-of-renal-biopsy-in-the-diagnosis-of-acute-poststreptococcal-glomerulonephritis-apsgn
American Society of Nephrology | Kidney Week - Abstract Details (2022)American Society of Nephrology | Kidney Week - Abstract Details (2022)
Anti-Glomerular Basement Membrane (anti-GBM) is an autoimmune disease involving glomerular and pulmonary capillaries diagnosed ... Anti-Glomerular Basement Membrane Disease Sans Kidney Involvement. Session Information. *AKI: Mechanisms - I. November 03, 2022 ... Anti-Glomerular Basement Membrane Disease Sans Kidney Involvement. November 03, 2022 , 10:00 AM - 12:00 PM ... Due to the concern for progression of untreated anti-GBM disease, the patient was given high dose steroids, plasma exchange, ...
https://www.asn-online.org/education/kidneyweek/2022/program-abstract.aspx?controlId=3770881
DeCS 2007 - Deleted termsDeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs.bvs.br/I/del_i2007.htm
Diffuse Proliferative Glomerulonephritis Clinical Presentation: History, Physical ExaminationDiffuse Proliferative Glomerulonephritis Clinical Presentation: History, Physical Examination
... used to describe a distinct histologic form of glomerulonephritis common to various types of systemic inflammatory diseases, ... Anti-glomerular basement membrane disease during the COVID-19 pandemic. Kidney Int. 2020 Sep. 98 (3):780-781. [QxMD MEDLINE ... except for anti-glomerular basement membrane [GBM] disease) a granular deposition of immunoglobulins, complement, and fibrin ... The clinicopathologic characteristics and outcome of atypical anti-glomerular basement membrane nephritis. Kidney Int. 2016 Apr ...
https://emedicine.medscape.com/article/239646-clinical
FDA warns about rare but serious risks of stroke and blood vessel wall tears with multiple sclerosis drug Lemtrada (alemtuzumab...FDA warns about rare but serious risks of stroke and blood vessel wall tears with multiple sclerosis drug Lemtrada (alemtuzumab...
Serious autoimmune problems, including immune thrombocytopenic purpura and anti-glomerular basement membrane disease ...
https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-rare-serious-risks-stroke-and-blood-vessel-wall-tears-multiple-sclerosis-drug
US8445515B2 - C5aR antagonists - Google Patents
... methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors. ... 208000008637 Anti-Glomerular Basement Membrane Disease Diseases 0.000 description 2 * 206010059512 Apoptosis Diseases 0.000 ... 206010064930 Age-related macular degeneration Diseases 0.000 description 3 * 206010001897 Alzheimers disease Diseases 0.000 ... 206010028154 Multi-organ failure Diseases 0.000 description 3 * 206010053643 Neurodegenerative disease Diseases 0.000 ...
https://patents.google.com/patent/US8445515/en
Goodpasture 病 - 症状、诊断和治疗 | BMJ Best PracticeGoodpasture 病 - 症状、诊断和治疗 | BMJ Best Practice
Anti-glomerular basement membrane disease. Kidney Int. 2003 Jul 7;64(7):1535-50. http://www.ncbi.nlm.nih.gov/pubmed/12969182? ... RGP has helped Genzyme develop educational materials for neurologists regarding the increased risk of Goodpastures disease ...
https://bestpractice.bmj.com/topics/zh-cn/479
Class of 2018 Scholarly Activity | Texas Tech University Health Sciences CenterClass of 2018 Scholarly Activity | Texas Tech University Health Sciences Center
Seronegative Anti-glomerular Basement Membrane Disease Resulting in Dialysis Dependence. American Journal of Kidney Diseases. ... Inflammatory Bowel Diseases 2013 19:8(1662-1670). *Perianal crohns disease is associated with distal colonic disease, ibd ... Perianal Crohns Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and ... erythema nodosum in inflammatory bowel disease patients. Weizman A, Huang B. Panikkath D et al. Inflammatory Bowel diseases ...
https://www.ttuhsc.edu/medicine/internal/residency-program/class-of-2018-scholarly.aspx
Dr Jonathan ErlichDr Jonathan Erlich
Erlich JH; Sevastos J; Pussell BA, 2004, Goodpastures disease: Antiglomerular basement membrane disease, Nephrology, vol. 9 ... Malliaros J; Holdsworth SR; Wojta J; Erlich J; Tipping PG, 1993, Glomerular fibrinolytic activity in anti-GBM ... Erlich JH; Tipping PG; Holdsworth SR, 1996, T cell depletion reduces augmentation of glomerular tissue factor and glomerular ... Chan R; Brooks R; Erlich J; Chow J; Suranyi M, 2007, THE ROLE OF KIDNEY DISEASE RELATED LOSS IN DIALYSIS PATIENTS QUALITY OF ...
https://www.unsw.edu.au/staff/jonathan-erlich
Frontiers | Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous...Frontiers | Characteristics of Anti-Contactin1 Antibody-Associated Autoimmune Nodopathies With Concomitant Membranous...
The early detection and isotyping of anti-CNTN1 and anti-PLA2R antibodies and the monitoring of isotype switching may be ... Case reports of anti-CNTN1 antibody-associated AN, anti-CNTN1 antibody-associated AN with MN, and CIDP with MN were retrieved ... Case reports of anti-CNTN1 antibody-associated AN, anti-CNTN1 antibody-associated AN with MN, and CIDP with MN were retrieved ... Five patients had anti-CNTN1 antibody-associated AN with MN. Among these patients, males accounted for the majority of cases ( ...
https://www.frontiersin.org/articles/10.3389/fimmu.2021.759187/full
Glomerulonephritis ArticleGlomerulonephritis Article
Anti-glomerular basement membrane disease. *Rapidly progressive glomerulonephritis. *Granulomatosis with polyangiitis. * ... Anti-glomerular basement membrane (GBM) GN - Anti-GBM GN. *Monoclonal Ig GN - Proliferative GN with monoclonal Ig deposits, ... and anti-ds-DNA, anti-glomerular basement membrane (GBM) to rule out collagenopathy as the underlying cause of GN. ... Thickening of glomerular basement membrane appears as thickened capillary walls on light microscopy. However, on electron ...
https://www.statpearls.com/ArticleLibrary/viewarticle/22279
Glomerular Basement Membrane Antibodies, IgG, Serum - Mayo Clinic Laboratories | Pediatric Catalog
1. Pusey CD: Anti-glomerular basement membrane disease. Kidney Int 2003;64:1535-1550 ... Test ID GBM Glomerular Basement Membrane Antibodies, IgG, Serum Reporting Name. Glomerular Basement Membrane IgG Ab ... Glomerular basement membrane antibodies detected by immunoassay have been reported to be highly specific for Goodpasture ... Antibodies to glomerular basement membrane (GBM) antigens cause glomerulonephritis, Goodpasture syndrome (glomerulonephritis, ...
https://pediatric.testcatalog.org/show/GBM
Die Rolle von Annexin A1 im Tiermodell der rasch progressiven GlomerulonephritisDie Rolle von Annexin A1 im Tiermodell der rasch progressiven Glomerulonephritis
Die a-GBM-Glomerulonephritis wird unter anderem mit Glucocorticoiden behandelt, die sowohl antiinflammatorische als auch anti- ... Die anti-glomeruläre Basalmembran-Antikörper vermittelte Glomerulonephritis (a-GBM-Glomerulonephritis) ist eine ernstzunehmende ... Acute kidney disease like the anti-glomerular basement membrane disease (a-GBM-disease) are serious diseases which may give ... For the treatment of a-GBM-disease glucocorticoids play an important role. They exhibit anti-inflammatory and anti-fibrotic ...
https://depositonce.tu-berlin.de/items/277f051d-cb2b-4cdd-bd14-4d9e144e17ce
Renal SciencesRenal Sciences
Autoimmunity may result in kidney injury and cause auto-immune diseases like anti-glomerular basement membrane disease, ... Timely diagnosis and treatment may prevent the progression of the disease. The disease is diagnosed using certain blood and ... Polycystic Kidney Disease. It is a genetic disorder, in which cysts or fluid-filled sacs are formed in the kidney and impair ... Chronic Kidney Disease (CKD). Also called chronic kidney failure, CKD is a progressive, irreversible loss of kidney function ...
https://www.manipalhospitals.com/baner/specialities/renal-sciences/
Find Research outputs - Manipal Academy of Higher Education, Manipal, India
Crescentic glomerulonephritis due to coexistent IgA nephropathy and anti-glomerular basement membrane disease in a patient with ... Critical evaluation of drug promotional literature for drugs used in cardiovascular diseases. Saibhavana, D., Chowta, M. N. & ... Cross-cultural adaptation, validation and reliability of the South Indian (Kannada) version of the Kidney Disease and Quality ... COVID-19 disease: A case report. Shenoy, S. V., Rao, I. R., Prabhu, R. A., Nagaraju, S. P., Paramasivam, G., Rangaswamy, D., ...
https://manipal.pure.elsevier.com/en/publications/?page=149&ordering=title&descending=false&showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=
JCI - Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced...JCI - Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced...
Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced ... caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred ... Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and ... Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and ...
https://www.jci.org/articles/view/36728/pdf
EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis | Annals of the Rheumatic DiseasesEULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis | Annals of the Rheumatic Diseases
Long-term outcome of anti-glomerular basement membrane antibody disease treated with plasma exchange and immunosuppression. Ann ... There is also potential benefit for PLEX in patients with AAV who are also anti-glomerular basement membrane (GBM) antibody ... particularly those in whom there is linear staining of IgG on the glomerular basement membrane, and PLEX should be performed ... for MPO negative disease, 100% for PR3 persistent disease and 92% for PR3 negative disease. ...
https://ard.bmj.com/content/75/9/1583?ijkey=d742dd8f0a16f11effdec102667946b2c2a99c33&keytype2=tf_ipsecsha
DeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs2014.bvsalud.org/I/del_i2007.htm
DeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs2013.bvsalud.org/I/del_i2007.htm
DeCSDeCS
Anti-Glomerular Basement Membrane Disease Entry term(s). Anti GBM Disease Anti Glomerular Basement Membrane Disease Anti-GBM ... Anti GBM Disease. Anti Glomerular Basement Membrane Disease. Anti-GBM Disease. Goodpasture Syndrome. Goodpastures Syndrome. ... Anti-Glomerular Basement Membrane Disease - Preferred Concept UI. M0029493. Scope note. An autoimmune disease of the KIDNEY and ... Anti-Glomerular Basement Membrane Disease Descriptor Spanish: Enfermedad por Anticuerpos Antimembrana Basal Glomerular Spanish ...
https://decs.bvsalud.org/en/ths/resource/?id=33358
Code System Concept
Anti-glomerular basement membrane disease Active Synonym false false 3792845013 Anti GBM - antiglomerular basement membrane ... Anti-glomerular basement membrane disease (disorder). Code System Preferred Concept Name. Anti-glomerular basement membrane ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=788613004
HuGE Navigator|Phenopedia|PHGKBHuGE Navigator|Phenopedia|PHGKB
Anti-Glomerular Basement Membrane Disease 9 genes has been reported with Anti-Glomerular Basement Membrane Disease ... in Phenopedia reflects only the indexed disease term, but the number in the HuGE Literature Finder reflects all text searches ...
https://phgkb.cdc.gov/PHGKB/phenoPedia.action?firstQuery=Anti-Glomerular+Basement+Membrane+Disease&cuiID=C0403529&typeSubmit=GO&check=y&which=2&pubOrderType=pubD
DeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs2010.bvsalud.org/I/del_i2007.htm
DeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs2012.bvsalud.org/I/del_i2007.htm
DeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs2018.bvsalud.org/I/del_i2007.htm
DeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs2017.bvsalud.org/I/del_i2007.htm
DeCS 2007 - Deleted terms
C08 - Respiratory Tract Diseases. Goodpasture Syndrome. Anti-Glomerular Basement Membrane Disease. C12 - Male Urogenital ...
https://decs2007.bvsalud.org/I/del_i2007.htm

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