Anti bacterial agents. Medical search

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.

The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)

Substances that reduce the growth or reproduction of BACTERIA.

A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections.

Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).

Bacteria which retain the crystal violet stain when treated by Gram's method.

Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.

Bacteria which lose crystal violet stain but are stained pink when treated by Gram's method.

Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.

Infections by bacteria, general or unspecified.

The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.

A publication issued at stated, more or less regular, intervals.

Individual's rights to obtain and use information collected or generated by others.

Autosomal recessive disorder caused by mutations in the mevalonate kinase gene. Because of the mutations cholesterol biosynthesis is disrupted and MEVALONIC ACID accumulates. It is characterized by a range of symptoms, including dysmorphic FACIES, psychomotor retardation, CATARACT, hepatosplenomegaly, CEREBELLAR ATAXIA, elevated IMMUNOGLOBULIN D, and recurrent febrile crises with FEVER; LYMPHADENOPATHY; ARTHRALGIA; EDEMA; and rash.

A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.

The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)

"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.

A species of gram-negative bacteria (currently incertae sedis) causing multisystem disease in CATTLE.

A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.

Heat and stain resistant, metabolically inactive bodies formed within the vegetative cells of bacteria of the genera Bacillus and Clostridium.

A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

The reproductive elements of lower organisms, such as BACTERIA; FUNGI; and cryptogamic plants.

Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.

An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.

A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.

Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.

Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)

Procedures carried out with regard to the teeth or tooth structures preparatory to specified dental therapeutic and surgical measures.

A plant genus of the LAMIACEAE family. It is known as a spice and medicinal plant.

A plant species of the genus OCIMUM, family LAMIACEAE. It is a condiment with carminative properties.

Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.

A group of DITERPENES cyclized into 3-ring PHENANTHRENES.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.

Spread and adoption of inventions and techniques from one geographic area to another, from one discipline to another, or from one sector of the economy to another. For example, improvements in medical equipment may be transferred from industrial countries to developing countries, advances arising from aerospace engineering may be applied to equipment for persons with disabilities, and innovations in science arising from government research are made available to private enterprise.

The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)

The fraudulent misrepresentation of the diagnosis and treatment of disease.

Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.

Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. (1/41157)

Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin. (+info)

Modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s. (2/41157)

A carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin, ampicillin, carbenicillin, and cephaloridine than that of the parent strain. The mutant was more resistant than the parent strain to all of the beta-lactam antibiotics tested, and 50% inhibition values for these compounds against membrane-bound model transpeptidase activity paralleled this increase. The resistance of the mutant to kanamycin, streptomycin, and chloramphenicol was unchanged. (+info)

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (3/41157)

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to the drug or a metabolic aberation of the host permitting the accumulation of hepatotoxic metabolites. The syndromes of hepatic disease produced by drugs have been classified hepatocellular, hepatocanalicular, mixed and canalicular. Measurement of serum enzyme activities has provided a powerful tool for studies of hepatotoxicity. Their measurement requires awareness of relative specificity, knowledge of the mechanisms involved, and knowledge of the relationship between known hepatotoxic states and elevated enzyme activities. (+info)

Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. (4/41157)

BACKGROUND: High-level gentamicin resistance in enterococci and staphylococci is conferred by AAC(6')-APH(2"), an enzyme with 6'-N-acetyltransferase and 2"-O-phosphotransferase activities. The presence of this enzyme in pathogenic gram-positive bacteria prevents the successful use of gentamicin C and most other aminoglycosides as therapeutic agents. RESULTS: In an effort to understand the mechanism of aminoglycoside modification, we expressed AAC(6')-APH(2") in Bacillus subtilis. The purified enzyme is monomeric with a molecular mass of 57 kDa and displays both the expected aminoglycoside N-acetyltransferase and O-phosphotransferase activities. Structure-function analysis with various aminoglycosides substrates reveals an enzyme with broad specificity in both enzymatic activities, accounting for AAC(6')-APH(2")'s dramatic negative impact on clinical aminoglycoside therapy. Both lividomycin A and paromomycin, aminoglycosides lacking a 6'-amino group, were acetylated by AAC(6')-APH(2"). The infrared spectrum of the product of paromomycin acetylation yielded a signal consistent with O-acetylation. Mass spectral and nuclear magnetic resonance analysis of the products of neomycin phosphorylation indicated that phosphoryl transfer occurred primarily at the 3'-OH of the 6-aminohexose ring A, and that some diphosphorylated material was also present with phosphates at the 3'-OH and the 3"'-OH of ring D, both unprecedented observations for this enzyme. Furthermore, the phosphorylation site of lividomycin A was determined to be the 5"-OH of the pentose ring C. CONCLUSIONS: The bifunctional AAC(6')-APH(2") has the capacity to inactivate virtually all clinically important aminoglycosides through N- and O-acetylation and phosphorylation of hydroxyl groups. The extremely broad substrate specificity of this enzyme will impact on future development of aminoglycosides and presents a significant challenge for antibiotic design. (+info)

Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. (5/41157)

BACKGROUND: Since the emergence of methicillin-resistant Staphylococcus aureus, the glycopeptide vancomycin has been the only uniformly effective treatment for staphylococcal infections. In 1997, two infections due to S. aureus with reduced susceptibility to vancomycin were identified in the United States. METHODS: We investigated the two patients with infections due to S. aureus with intermediate resistance to glycopeptides, as defined by a minimal inhibitory concentration of vancomycin of 8 to 16 microg per milliliter. To assess the carriage and transmission of these strains of S. aureus, we cultured samples from the patients and their contacts and evaluated the isolates. RESULTS: The first patient was a 59-year-old man in Michigan with diabetes mellitus and chronic renal failure. Peritonitis due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus peritonitis associated with dialysis. The removal of the peritoneal catheter plus treatment with rifampin and trimethoprim-sulfamethoxazole eradicated the infection. The second patient was a 66-year-old man with diabetes in New Jersey. A bloodstream infection due to S. aureus with intermediate resistance to glycopeptides developed after 18 weeks of vancomycin treatment for recurrent methicillin-resistant S. aureus bacteremia. This infection was eradicated with vancomycin, gentamicin, and rifampin. Both patients died. The glycopeptide-intermediate S. aureus isolates differed by two bands on pulsed-field gel electrophoresis. On electron microscopy, the isolates from the infected patients had thicker extracellular matrixes than control methicillin-resistant S. aureus isolates. No carriage was documented among 177 contacts of the two patients. CONCLUSIONS: The emergence of S. aureus with intermediate resistance to glycopeptides emphasizes the importance of the prudent use of antibiotics, the laboratory capacity to identify resistant strains, and the use of infection-control precautions to prevent transmission. (+info)

Bioterrorism alleging use of anthrax and interim guidelines for management--United States, 1998. (6/41157)

From October 30 through December 23, 1998, CDC received reports of a series of bioterroristic threats of anthrax exposure. Letters alleged to contain anthrax were sent to health clinics on October 30, 1998, in Indiana, Kentucky, and Tennessee. During December 17-23 in California, a letter alleged to contain anthrax was sent to a private business, and three telephone threats of anthrax contamination of ventilation systems were made to private and public buildings. All threats were hoaxes and are under investigation by the Federal Bureau of Investigation (FBI) and local law enforcement officials. The public health implications of these threats were investigated to assist in developing national public health guidelines for responding to bioterrorism. This report summarizes the findings of these investigations and provides interim guidance for public health authorities on bioterrorism related to anthrax. (+info)

Acinetobacter bacteremia in Hong Kong: prospective study and review. (7/41157)

The epidemiological characteristics of 18 patients with acinetobacter bacteremia were analyzed. Patients (mean age, 55.5 years) developed bacteremia after an average of 14.1 days of hospitalization. Fifteen of 16 patients survived bacteremia caused by Acinetobacter baumannii. Cultures of blood from the remaining two patients yielded Acinetobacter lwoffii. Most patients (78%) resided in the general ward, while four patients (22%) were under intensive care. Genotyping by arbitrarily primed polymerase chain reaction analysis and the temporal sequence of isolation were more useful than phenotyping by antimicrobial susceptibility in the determination of the source of bacteremia, and the intravascular catheter was the leading infection source (39% of cases). The possibility of an association of glucose with the pathogenesis of acinetobacter infection was raised. (+info)

Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. (8/41157)

New drugs are needed for preventing drug-resistant Plasmodium falciparum malaria. The prophylactic efficacy of azithromycin against P. falciparum in malaria-immune Kenyans was 83%. We conducted a double-blind, placebo-controlled trial to determine the prophylactic efficacy of azithromycin against multidrug-resistant P. falciparum malaria and chloroquine-resistant Plasmodium vivax malaria in Indonesian adults with limited immunity. After radical cure therapy, 300 randomized subjects received azithromycin (148 subjects, 750-mg loading dose followed by 250 mg/d), placebo (77), or doxycycline (75, 100 mg/d). The end point was slide-proven parasitemia. There were 58 P. falciparum and 29 P. vivax prophylaxis failures over 20 weeks. Using incidence rates, the protective efficacy of azithromycin relative to placebo was 71.6% (95% confidence interval [CI], 50.3-83.8) against P. falciparum malaria and 98.9% (95% CI, 93.1-99.9) against P. vivax malaria. Corresponding figures for doxycycline were 96.3% (95% CI, 85.4-99.6) and 98% (95% CI, 88.0-99.9), respectively. Daily azithromycin offered excellent protection against P. vivax malaria but modest protection against P. falciparum malaria. (+info)

Anti-Infective Agents in Medicinal Chemistry. 6 (1): 49-56. doi:10.2174/187152107779314179. Archived (PDF) from the original on ... Quinolones exert their antibacterial effect by preventing bacterial DNA from unwinding and duplicating.[60] Specifically they ... Anti-Infective Agents in Medicinal Chemistry. 6 (1): 49-56. doi:10.2174/187152107779314179.. ... Quinolones can be classified into generations based on their antibacterial spectrum.[81][82] The earlier-generation agents are ...

https://en.wikipedia.org/wiki/Fluoroquinolone-associated_disability

Anti-Infective Agents in Medicinal Chemistry. Bentham Science Publishers. 6 (1): 49-56. doi:10.2174/187152107779314179.. ... Quinolones exert their antibacterial effect by preventing bacterial DNA from unwinding and duplicating.[59] The majority of ... Anti-Infective Agents in Medicinal Chemistry. Bentham Science Publishers. 6 (1): 49-56. doi:10.2174/187152107779314179. ... Quinolones can be classified into generations based on their antibacterial spectrum.[79][80] The earlier-generation agents are ...

https://en.wikipedia.org/wiki/Adverse_effects_of_fluoroquinolones

... need DHFR to grow and multiply and hence inhibitors selective for bacterial DHFR have found application as antibacterial agents ... Regardless, trimethoprim and sulfamethoxazole in combination has been used as an antibacterial agent for decades.[37] ... Trimethoprim, an antibiotic, inhibits bacterial DHFR while methotrexate, a chemotherapy agent, inhibits mammalian DHFR. However ... Hawser S, Lociuro S, Islam K (March 2006). "Dihydrofolate reductase inhibitors as antibacterial agents". Biochemical ...

https://en.wikipedia.org/wiki/Dihydrofolate_reductase

Examples include anti-allergic, anti-inflammatory, antioxidant, anti-microbial (antibacterial, antifungal, and antiviral), anti ... Cushnie TP, Lamb AJ (2005). "Antimicrobial activity of flavonoids" (PDF). International Journal of Antimicrobial Agents. 26 (5 ... the ability to suppress bacterial virulence factors in numerous in vitro and a limited number of in vivo studies. Noteworthy ... Babu PV, Liu D, Gilbert ER (2013). "Recent advances in understanding the anti-diabetic actions of dietary flavonoids". The ...

https://en.wikipedia.org/wiki/Flavonoid

Lysobactin, a novel antibacterial agent produced by Lysobacter sp. II. Biological properties. J Antibiot (Tokyo) 41:1745-51. ... Bean rust biological control using bacterial agents. Crop Protection 20:395-402. Jochum, C. C., L. E. Osborne, and G. Y. Yuen. ... Lysobactin, a novel antibacterial agent produced by Lysobacter sp. I. Taxonomy, isolation and partial characterization. J ... A new anti-MRSA antibiotic complex, WAP-8294A. I. Taxonomy, isolation and biological activities. J Antibiot (Tokyo) 51:929-35. ...

https://en.wikipedia.org/wiki/Lysobacter

Anti-bacterial agent. Penicillin. The bacterial cell wall is composed of peptidoglycan. During bacterial growth the present ... Anti-fungi agent. Azole. Ergosterol is a sterol that forms the cell surface membrane of the fungi. Azole can inhibit its ... Anti-viral agent. Saquinavir. HIV protease is needed to cleave Gag-Pol polyprotein into 3 individual proteins so they can ...

https://en.m.wikipedia.org/wiki/Active_site

A number of wound dressings containing silver as an anti-bacterial have been cleared by the U.S. Food and Drug Administration ( ... "Antimicrobial Agents and Chemotherapy. 6 (5): 637-642. doi:10.1128/AAC.6.5.637. PMC 444706 . PMID 15825319.. ... likely due to the release of silver into the bacterial culture.[52] The antibacterial action of electrodes coated with silver ... Antibacterial cream[edit]. See also: Silver sulfadiazine. A 2012 systematic review reported that topical silver showed a ...

https://en.wikipedia.org/wiki/Colloidal_silver

In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ... Anti-allergy: mast cell inhibitors. *Anti-glaucoma: adrenergic agonists, beta-blockers, carbonic anhydrase inhibitors/ ... of new data on the development of novel antibiotics and antibacterials and on the use of biological agents for antibacterial ...

https://en.wikipedia.org/wiki/Medicines

Infectious complications: an appropriate course of antibacterial drugs can be taken according to the infectious agent. ... Spontaneous bacterial peritonitis can develop where there is ascites present. This is a frequent development in children but ... Proteinuria: the loss of proteins from the urine is caused by many pathological agents and infection by these agents has to be ... Treatment is with oral anticoagulants (not heparin as heparin acts via anti-thrombin 3 which is lost in the proteinuria so it ...

https://en.wikipedia.org/wiki/Nephrotic_syndrome

"Pharmacokinetics and pharmacodynamics of antibacterial agents". Infectious Disease Clinics of North America. 23 (4): 791-815, ... "Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action". Cellular ... The uricosuric agent probenecid proved to be suitable. When probenecid and penicillin are administered together, probenecid ... β-Lactam antibiotics inhibit the formation of peptidoglycan cross-links in the bacterial cell wall; this is achieved through ...

https://en.m.wikipedia.org/wiki/Penicillin

Mahajan, GB (2012). "Antibacterial agents from actinomycetes - a review". Frontiers in Bioscience. 4: 240-53. doi:10.2741/e373. ... Actinobacteria is one of the dominant bacterial phyla and contains one of the largest of bacterial genera, Streptomyces.[3] ... Pandey, B.; Ghimire, P.; Agrawal, V.P. (January 12-15, 2004). Studies on the antibacterial activity of the Actinomycetes ... Although some of the largest and most complex bacterial cells belong to the Actinobacteria, the group of marine Actinomarinales ...

https://en.m.wikipedia.org/wiki/Actinobacteria

Bacterial efflux pumps[edit]. Efflux pumps are proteinaceous transporters localized in the cytoplasmic membrane of all kinds of ... Cushnie, T.P. Tim; Cushnie, Benjamart; Lamb, Andrew J. (2014). "Alkaloids: An overview of their antibacterial, antibiotic- ... enhancing and antivirulence activities". International Journal of Antimicrobial Agents. 44 (5): 377-86. doi:10.1016/j. ... Bacterial efflux transporters are classified into five major superfamilies, based on their amino acid sequence and the energy ...

https://en.wikipedia.org/wiki/Efflux_(microbiology)

Zhanel, G.G (10 February 2016). "Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent". Drugs. 76 (5): 567-588. ... the first tetracycline-resistant bacterial pathogen was identified. Since then, tetracycline-resistant bacterial pathogens have ... "Antimicrobial Agents and Chemotherapy. 7 (1): 46-49. doi:10.1128/aac.7.1.46. ISSN 0066-4804. PMC 429070. PMID 1137358.. ... "Antimicrobial Agents and Chemotherapy. 60 (8): 4433-4441. doi:10.1128/AAC.00594-16. PMC 4958212. PMID 27246781.. ...

https://en.m.wikipedia.org/wiki/Tetracycline_antibiotics

Bacterial[edit]. Bacterial efflux transporters are classified into five major superfamilies, based on their amino acid sequence ... "Antimicrobial Agents and Chemotherapy. 53 (11): 4673-7. doi:10.1128/AAC.00853-09. PMC 2772354. PMID 19687245.. ... "Alkaloids: an overview of their antibacterial, antibiotic-enhancing and antivirulence activities". International Journal of ... This active efflux mechanism is responsible for various types of resistance to bacterial pathogens within bacterial species - ...

https://en.wikipedia.org/wiki/Efflux_

It is a good descaler, soap-scum remover, and a registered anti-bacterial agent. It is also economically beneficial as well as ... Lactic acid is used as a food preservative, curing agent, and flavoring agent.[41] It is an ingredient in processed foods and ... In winemaking, a bacterial process, natural or controlled, is often used to convert the naturally present malic acid to lactic ... Lactic acid is produced industrially by bacterial fermentation of carbohydrates (sugar, starch) or by chemical synthesis from ...

https://en.m.wikipedia.org/wiki/Α-Hydroxypropionic_acid

... a novel oxazolidinone antibacterial agent". Antimicrob. Agents Chemother. 53: 3236-9. doi:10.1128/AAC.00228-09. PMC 2715649 . ... Tedizolid has been approved by the U.S Food and Drug Administration on June 20, 2014, for the treatment of acute bacterial Skin ... "Analysis of the Phase 3 ESTABLISH Trials of Tedizolid versus Linezolid in Acute Bacterial Skin and Skin Structure Infections". ... "New FDA task force will support innovation in antibacterial drug development". September 2012.. ...

https://en.wikipedia.org/wiki/Tedizolid

Anderson, Rosaleen (2012). Antibacterial agents chemistry, mode of action, mechanisms of resistance, and clinical applications ... hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial ... Further advances in anti-infective researchEdit. The aftermath of World War II saw an explosion in the discovery of new classes ... Early anti-infective research: Salvarsan, Prontosil, Penicillin and vaccinesEdit. The development of drugs for the treatment of ...

https://en.m.wikipedia.org/wiki/Pharmaceutical_company

Agents Chemother. 23 (2): 267-72. doi:10.1128/aac.23.2.267. PMC 186035 . PMID 6340603. Gattas MV, Forteza R, Fragoso MA, ... The oxidation of -SH groups in the bacterial cytoplasmic membrane results in loss of the ability to transport glucose and also ... White WE, Pruitt KM, Mansson-Rahemtulla B (February 1983). "Peroxidase-Thiocyanate-Peroxide Antibacterial System Does Not ... OSCN− has also been identified as an antimicrobial agent in milk, saliva, tears, and mucus. OSCN− is considered as safe product ...

https://en.wikipedia.org/wiki/Hypothiocyanite

Common anti-bacterial agents that work by destroying vegetative cell walls do not affect endospores. Endospores are commonly ... Bacterial endospores are resistant to antibiotics, most disinfectants, and physical agents such as radiation, boiling, and ... Abel-Santos, E (editor) (2012). Bacterial Spores: Current Research and Applications. Caister Academic Press. ISBN 978-1-908230- ... Further information: Bacterial morphological plasticity. Under conditions of starvation, especially the lack of carbon and ...

https://en.m.wikipedia.org/wiki/Endospore

Examples of antibacterial sutures that are coated with the antibacterial agent triclosan include... In many institutions these ... Triclosan has been employed as a selective agent in molecular cloning. A bacterial host transformed by a plasmid harboring a ... This effect may also occur with chlorhexidine gluconate and PCMX, among other antibacterial agents.[46][47] Other studies have ... Triclosan (sometimes abbreviated as TCS) is an antibacterial and antifungal agent present in some consumer products, including ...

https://en.m.wikipedia.org/wiki/Triclosan

2007). "Antibacterial agents". In Murray, PR; et al. (eds.). Manual of Clinical Microbiology (9th ed.). Washington D.C.: ASM ... "Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action". Cellular ... Hence, there are two main modes of bacterial resistance to β-lactams: If the bacterium produces the enzyme β-lactamase or the ... Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used ...

https://en.wikipedia.org/wiki/Β-lactam_antibiotic

... a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721". Antimicrobial Agents ... As of 2014, bacterial resistance to linezolid has remained low. Linezolid is a member of the oxazolidinone class of medications ... Ford CW, Zurenko GE, Barbachyn MR (August 2001). "The discovery of linezolid, the first oxazolidinone antibacterial agent". ... Brickner SJ (1996). "Oxazolidinone antibacterial agents". Current Pharmaceutical Design. 2 (2): 175-94. Detailed review of the ...

https://en.wikipedia.org/wiki/Linezolid

Antibacterial therapeutic agents". Feigin & Cherry's textbook of pediatric infectious diseases (6th ed.). Philadelphia, PA: ... Need for the determination of chloramphenicol levels in the treatment of bacterial-purulent meningitis with chloramphenicol ... Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents". Goodman & Gilman's The Pharmacological Basis of ... Two pathophysiologic mechanisms are thought to play a role in the development of gray baby syndrome after exposure to the anti- ...

https://en.wikipedia.org/wiki/Gray_baby_syndrome

Melander RJ, Zurawski DV, Melander C (2018). "Narrow-Spectrum Antibacterial Agents". MedChemComm. 9: 12-21. doi:10.1039/ ... Low propensity for bacterial resistance development. Often, the exact species of bacteria causing the illness is unknown, in ...

https://en.wikipedia.org/wiki/Narrow-spectrum_antibiotic

ISBN 978-0-12-526451-8. Bryskier A. "Antibacterial Agents; Structure Activity Relationships" (PDF). p. 143. Archived from the ... The primary means of bacterial resistance to macrolides occurs by post-transcriptional methylation of the 23S bacterial ... Macrolide antibiotics do so by binding reversibly to the P site on the 50S subunit of the bacterial ribosome. This action is ... Classification of agents Pharmamotion. Author: Gary Kaiser. The Community College of Baltimore County. Retrieved on July 31, ...

https://en.wikipedia.org/wiki/Macrolide

"Targeting antibacterial agents by using drug-carrying filamentous bacteriophages". Antimicrobial Agents and Chemotherapy. 50 (6 ... The viral genome effectively replaces the bacterial genome, halting the bacterial infection. The bacterial cell causing the ... Purified recombinant phage enzymes can be used as separate antibacterial agents in their own right. Phage therapy also has the ... Shasha SM, Sharon N, Inbar M (February 2004). "[Bacteriophages as antibacterial agents]". Harefuah (in Hebrew). 143 (2): 121-25 ...

https://en.wikipedia.org/wiki/Phage_therapy

"Narrow-Spectrum Antibacterial Agents". MedChemComm. 9: 12-21. doi:10.1039/C7MD00528H. ISSN 2040-2503. PMC 5839511. PMID ... Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome ( ... Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. ISSN 1098-6596. PMC 6325184. PMID 30397052.. ... indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the ...

https://en.wikipedia.org/wiki/Antimicrobial_spectrum

Hiraki, J. (1995). "Basic and applied studies on ε-polylysine". Journal of Antibacterial Antifungal Agents. 23: 349-354. Mazia ... This eventually leads to the abnormal distribution of the cytoplasm causing damage to the bacterial cell that is produced by ... which offers a new way to deliver therapeutic agents specifically to the sites of injury after vascular damage. In 2010, ... which can be used either as surfactants or emulsifiers in the encapsulation of water-insoluble drugs or as antimicrobial agents ...

https://en.wikipedia.org/wiki/Polylysine

Agents with anti-pseudomonal activity, including doripenem, imipenem, and meropenem are not recommended in this population. ... Carbapenems are a class of highly effective antibiotic agents commonly used for the treatment of severe or high-risk bacterial ... Structure Activity Relationships "Antibacterial Agents; Structure Activity Relationships," André Bryskier MD; beginning at ... thus inhibiting bacterial cell wall synthesis. However, these agents individually exhibit a broader spectrum of activity ...

https://en.wikipedia.org/wiki/Carbapenem

Mechanism of Action of Antibacterial Agents. Berlin, Heidelberg: Springer Berlin Heidelberg. ISBN 3-642-46403-3.CS1 maint: ... extra text: authors list (link) Type strain of Streptomyces ederensis at BacDive - the Bacterial Diversity Metadatabase v t e. ...

https://en.wikipedia.org/wiki/Streptomyces_ederensis

Competence in S. pneumoniae is induced by DNA-damaging agents such as mitomycin C, fluoroquinolone antibiotics (norfloxacin, ... Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall components are all major ... Natural bacterial transformation involves the transfer of DNA from one bacterium to another through the surrounding medium. ... van de Beek, Diederik; de Gans, Jan; Tunkel, Allan R.; Wijdicks, Eelco F.M. (5 January 2006). "Community-Acquired Bacterial ...

https://en.wikipedia.org/wiki/S._pneumoniae

Three different PET contrast agents have been developed to image bacterial infections in vivo: [18F]maltose,[19] [18F] ... imaging of atherosclerosis to detect patients at risk of stroke is also feasible and can help test the efficacy of novel anti- ... PET has been widely used to image bacterial infections clinically by using fluorodeoxyglucose (FDG) to identify the infection- ... PET/CT-System with 16-slice CT; the ceiling mounted device is an injection pump for CT contrast agent ...

https://en.m.wikipedia.org/wiki/PET_scan

... virus is classified as a biosafety level 4 agent, as well as a Category A bioterrorism agent by the Centers for Disease ... balance as well as treating any bacterial infections that may develop.[33] Dialysis may be needed for kidney failure, and ... people to be careful of advertisements making unverified or fraudulent claims of benefits supposedly gained from various anti- ... Zubray G (2013). Agents of Bioterrorism: Pathogens and Their Weaponization. New York, NY, USA: Columbia University Press. pp. ...

https://en.m.wikipedia.org/wiki/Ebola_virus_disease

Hormonal agents[edit]. In women, the use of combined birth control pills can improve acne.[100] These medications contain an ... Proposed mechanisms for tea tree oil's anti-acne effects include antibacterial action against C. acnes and anti-inflammatory ... The anaerobic bacterial species Cutibacterium acnes (formerly Propionibacterium acnes) contributes to the development of acne, ... "Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. PMC 6325184. PMID 30397052.. ...

https://en.wikipedia.org/wiki/Acne_vulgaris

Other agents causing ophthalmia neonatorum include Herpes simplex virus (HSV 2), Staphylococcus aureus, Streptococcus ... Other bacterial ophthalmia neonatorum should be treated by broad spectrum antibiotics drops and ointment for two weeks. ...

https://en.wikipedia.org/wiki/Neonatal_conjunctivitis

"Anti-vaxxers stopped the last Lyme disease vaccine. The FDA has just fast-tracked a new one". Newsweek. 25 July 2017. Archived ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... In the US, the National Institutes of Health has supported research into bacterial persistence.[282] ... Dotters-Katz, S; Kuller, J; Heine, P (September 2013). "Arthropod-Borne Bacterial Diseases in Pregnancy". Obstetrical & ...

https://en.wikipedia.org/wiki/Lyme_disease

https://en.wikipedia.org/wiki/Bacterial_spore

It is the causative agent of Johne's disease, which affects ruminants such as cattle, and suspected causative agent in human ... Bacterial cultures were regarded as Gold standards for detection of MAP. Detection is very limited in fresh tissues, food, and ... Professor John Hermon-Taylor of Kings College London is developing a new vector type anti MAP vaccine which he claims is both ... It has long been suspected as a causative agent in Crohn's disease in humans,[4][5] but studies have been unable to show ...

https://en.wikipedia.org/wiki/Mycobacterium_avium_subspecies_paratuberculosis

Some diseases, such as tetanus, cause disease not by bacterial growth but by bacterial production of a toxin. Tetanus toxin is ... Pasteur isolated the infectious agent from anthrax. He then derived a vaccine by altering the infectious agent so as to make it ... "Anti-vaccinationists past and present". BMJ. 325 (7361): 430-32. doi:10.1136/bmj.325.7361.430. PMC 1123944 . PMID 12193361 ... Pasteur also isolated a crude preparation of the infectious agent for rabies. In a brave piece of rapid medicine development, ...

https://en.wikipedia.org/wiki/Artificial_induction_of_immunity

... long-acting agents are recommended.[2] Long-acting agents partly work by reducing hyperinflation.[74] If long-acting ... COPD develops as a significant and chronic inflammatory response to inhaled irritants.[9] Chronic bacterial infections may also ... and act as anti-inflammatories. They show promise in decreasing the rate of exacerbations, but do not appear to change a ... External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. ...

https://en.wikipedia.org/wiki/COPD

... followed by death allowing for evaluation of novel cytoprotective agents. Potential tissue reparative agents can be evaluated ... These include β2-agonists, dopamine, insulin, allopurinol, and non-steroidal anti-inflammatory drugs (NSAIDs), such as ... Those with significant lower airway involvement may develop bacterial infection. Importantly, victims suffering body surface ... Other inhaled agents may be directly toxic (e.g. cyanide, carbon monoxide), or cause harm simply by displacing oxygen and ...

https://en.wikipedia.org/wiki/Acute_inhalation_injury

April 22, 1988 Anti-Acne Drug Faulted in Birth *^ CDC. January 21, 2000 Accutane®-Exposed Pregnancies -- California, 1999 MMWR ... bacterial infection Blood and lymphatic system *Anemia. *Increased red blood cell sedimentation rate ...

https://en.wikipedia.org/wiki/Isotretinoin

Fungal corneal ulcers require intensive application of topical anti-fungal agents. Viral corneal ulceration caused by herpes ... Bacterial keratitis is caused by Staphylococcus aureus, Streptococcus viridans, Escherichia coli, Enterococci, Pseudomonas, ... These infectious agents produce proteases and collagenases which break down the corneal stroma. Complete loss of the stroma can ... Bacterial corneal ulcer require intensive fortified antibiotic therapy to treat the infection. ...

https://en.m.wikipedia.org/wiki/Corneal_ulcer

These three anti-leprosy drugs are still used in the standard MDT regimens. None of them is used alone because of the risk of ... In 1873 G. H. Armauer Hansen in Norway discovered the causative agent of leprosy, Mycobacterium leprae. This was the first ... intended to mitigate bacterial resistance.[5] The first trials of combined treatment were carried out in Malta in the 1970s. ... The search for more effective anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s.[4] Later ...

https://en.wikipedia.org/wiki/History_of_leprosy

Aronson, edited by Jeffrey K. (2008). Meyler's side effects of analgesics and anti-inflammatory drugs. Amsterdam: Elsevier ... Urine culture is deemed positive if it shows a bacterial colony count of greater than or equal to 103 colony-forming units per ... "Antimicrobial agents for treating uncomplicated urinary tract infection in women". Cochrane Database of Systematic Reviews. 10 ... Urinary tract infections are the most frequent bacterial infection in women.[17] They occur most frequently between the ages of ...

https://en.wikipedia.org/wiki/Urinary_Tract_Infections

Nudler E, Mironov AS (Jan 2004). "The riboswitch control of bacterial metabolism". Trends in Biochemical Sciences. 29 (1): 11-7 ... "A model of proto-anti-codon RNA enzymes requiring L-amino acid homochirality". Journal of Molecular Evolution. 73 (1-2): 10-22 ...

https://en.wikipedia.org/wiki/RNA_world

Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor cell types such as hepatocellular carcinoma.[81 ... Some prokaryotes, including many archaea and the bacterial order Actinomycetales, also share homologs of the 20S proteasome, ... is the first proteasome inhibitor to reach clinical use as a chemotherapy agent.[102] Bortezomib is used in the treatment of ... Due to its role in generating the activated form of NF-κB, an anti-apoptotic and pro-inflammatory regulator of cytokine ...

https://en.m.wikipedia.org/wiki/Proteasome

Finlay BB, McFadden G (February 2006). "Anti-immunology: evasion of the host immune system by bacterial and viral pathogens". ... helps remove infectious agents.[2] Also, mucus traps infectious agents.[2] The gut flora can prevent the colonization of ... When host cells die, either by programmed cell death (also called apoptosis) or by cell injury due to a bacterial or viral ... Gómez-Gómez L, Boller T (June 2000). "FLS2: an LRR receptor-like kinase involved in the perception of the bacterial elicitor ...

https://en.wikipedia.org/wiki/Innate_immune_system

The first strategy has been tested by looking at dose-response anti-tumor effects during autophagy-induced therapies. These ... it recruits autophagy adaptor such as NDP52 leading to the formation of an autophagosome and bacterial degradation.[64] ... cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent ... "Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion". Nature. 482 (7385): 414-8. doi ...

https://en.wikipedia.org/wiki/Autophagy_

Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of ... "Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection". Journal of ...

https://en.wikipedia.org/wiki/Coagulation_factor_II_receptor

... should be given to possibility of strep species as cause that are still sensitive to traditional anti-staphylococcus agents ... Abscesses are caused by bacterial infection, parasites, or foreign substances. Bacterial infection is the most common cause.[8] ... They are usually caused by a bacterial infection.[8] Often many different types of bacteria are involved in a single infection. ... In those cases of abscess which do require antibiotic treatment, Staphylococcus aureus bacteria is a common cause and an anti- ...

https://en.wikipedia.org/wiki/Abscess

"Antimicrobial Agents and Chemotherapy. 38 (8): 1864-67. doi:10.1128/aac.38.8.1864. PMC 284652. PMID 7986023.. ... Bleeding from the ears and petechial hemorrhages in the skin also occurred."[193] The majority of deaths were from bacterial ... Wilson JC, von Itzstein M (July 2003). "Recent strategies in the search for new anti-influenza therapies". Current Drug Targets ... The first influenza virus to be isolated was from poultry, when in 1901 the agent causing a disease called "fowl plague" was ...

https://en.m.wikipedia.org/wiki/Influenza

In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ... Anti-allergy: mast cell inhibitors. *Anti-glaucoma: adrenergic agonists, beta-blockers, carbonic anhydrase inhibitors/ ... anti-allergics, antihistamines, NSAIDs, Corticosteroids For nutritionEdit. Tonics, electrolytes and mineral preparations ( ...

https://en.m.wikipedia.org/wiki/Pharmaceutical

On beef meat pieces, PEA reduced the bacterial cell count by 90% after incubation of the PEA treated and E. coli contaminated ... antiparkinson agents (e.g., selegiline), and vasopressors (e.g., ephedrine), among others. Many of these psychoactive compounds ... and acts as a potent anti-microbial against certain pathogenic strains of Escherichia coli (e.g., the O157:H7 strain) at ... Lynnes T, Horne SM, Prüß BM (2014). "ß-Phenylethylamine as a novel nutrient treatment to reduce bacterial contamination due to ...

https://en.m.wikipedia.org/wiki/Phenethylamine

A peptidergic agent (or drug) is a chemical which functions to directly modulate the peptide systems in the body or brain. An ... According to the Handbook of Biologically Active Peptides, some groups of peptides include plant peptides, bacterial/antibiotic ... prohibited substances on the World Anti-Doping Agency (WADA) Prohibited List, and are therefore prohibited for use by ...

https://en.m.wikipedia.org/wiki/Polypeptide

In the US, it is the second-most-common bacterial sexually transmitted infections; chlamydia remains first.[64][65] According ... Resistance to cefixime has reached a level such that it is no longer recommended as a first-line agent in the United States, ... and gonococci and commensal Neisseria species can coexist for long time periods in the pharynx and share anti-microbial ... Culture (growing colonies of bacteria in order to isolate and identify them) and Gram-stain (staining of bacterial cell walls ...

https://en.wikipedia.org/wiki/Gonorrhea

... or the presence of IgA anti-TG2 and/or anti-endomysial intestinal deposits, might be specific markers for celiac disease. ... Bressan, Paola; Kramer, Peter (2016). "Bread and Other Edible Agents of Mental Disease". Frontiers in Human Neuroscience. 10. ... alternative diagnoses may be identified such as fructose intolerance or small intestinal bacterial overgrowth, or a better ...

https://en.wikipedia.org/wiki/Non-celiac_gluten_sensitivity

"Neutrophil secretion products regulate anti-bacterial activity in monocytes and macrophages". Clinical & Experimental ... Antimicrobial agents (Defensins and Eosinophil cationic protein). *Enzymes *Acid hydrolases: further digest bacteria ... bacterial) proteins, lysozyme to break down bacterial cell walls, and myeloperoxidase (used to generate toxic bacteria-killing ... Ernst J. D. and Stendahl O., (editors), Phagocytosis of Bacteria and Bacterial Pathogenicity, Cambridge University Press, 2006 ...

https://en.wikipedia.org/wiki/Granulocytopenia

Ing articulung iti tungkul ya keng biological agent. Para kareng computer viruses, lawen ye ing Computer virus.. Para keng ... Lulan palalam anti mung PDF. *Kopiang malyaring i-print. In other projects *Wikimedia Commons ... Bacteriophages (bacterial viruses). Template:Viruses Dalerayan. Mekua ya king "https://pam.wikipedia.org/w/index.php?title= ...

https://pam.wikipedia.org/wiki/Virus

Antibacterial agents, in the form of chemically-based antibiotics (i.e. non-viral agents), such as penicillin or tetracycline, ... The panel of bacteriophages may also be used in combination with a suitable earner as an antibacterial or antiseptic agent. ... methods of identifying and producing such panels of bacteriophages and to the use of such panels as antibacterial agents, ... and they may be used to treat the bacterial infection. Accordingly, a bacterial pathogens own prophages from within its own ...

http://www.freepatentsonline.com/y2008/0317715.html

... the anti-bacterial agent) in soaps over the years, has negatively effected the environment. A recent study (12697 signatures on ... The use of triclosan (the anti-bacterial agent) in soaps over the years, has negatively effected the environment. A recent ... Urge Bath & Body Works to stop using Anti-Bacterial Agents. *by: Wendy Armitage ...

https://www.thepetitionsite.com/617/283/362/urge-bath-body-works-to-stop-using-anti-bacterial-agents-in-their-hand-soap/

... pyrazolyl-benzimidazole complexes with remarkable antibacterial activity† Karim Chkirate,a Khalid Karrouchi,b ... Discovery of new antibacterial agents. A study performed in collaboration with Moroccan universities and highlighted on the ... In particular a normalized minimum inhibitory concentration as low as 6.25 μg mL−1 for the bacterial strains was recorded for ... Discovery of new antibacterial agents. A study performed in collaboration with Moroccan universities and highlighted on the ...

https://uclouvain.be/en/research-institutes/imcn/most/news/discovery-of-new-antibacterial-agents.html

If new regulations are put into action manufacturing companies companies will have to prove the effectiveness of antibacterial ... "What Makes Antibacterial Soap Antibacterial?" 2014). The bacteria would release a bacterial enzyme that would bind to a ... Antibacterial Agents in the Therapy of Urinary Tract Infection. 1716 Words , 7 Pages SECTION TWO 1. Which antibacterial agent(s ... Antibacterial Studies Of Some Bisindolizine Compounds. 2365 Words , 10 Pages * Antibacterial Agents in the Therapy of Urinary ...

https://www.bartleby.com/essay/Antibacterial-Agent-Ticlosan-PKXWWJEEC8BRS

... some of which can damage our health or encourage bacterial resistance to antibiotics ... Cleaning products contain a dizzying array of antibacterial compounds, ... What are antibacterial agents and should we avoid using them?. Cleaning products contain a dizzying array of antibacterial ... What is an antibacterial?. Antibacterials are compounds that interfere with the growth and reproduction of bacteria, and can be ...

https://www.newscientist.com/article/2116448-what-are-antibacterial-agents-and-should-we-avoid-using-them/

Pharmacological Actions : Anti-Bacterial Agents : CK(2894) : AC(1251). Additional Keywords : Anti-Bacterial Agents, Bacterial ... Anti-Inflammatory Agents : CK(20859) : AC(8334). Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Eye ... Anti-Inflammatory Agents : CK(20859) : AC(8334). Additional Keywords : Anti-Bacterial Agents, Anti-Inflammatory Agents, Otitis ... Pharmacological Actions : Anti-Bacterial Agents : CK(2894) : AC(1251). Additional Keywords : Anti-Bacterial Agents, eczema, ...

https://greenmedinfo.com/category/keywords/anti-bacterial-agents

... synthetic fluorocycline antibacterial agent that is structurally similar to tigecycline with two modifications to the D ... The lung bacterial density was determined 26 h post-infection. For S. pneumoniae, IV eravacycline doses of 3, 6, and 12 mg/kg ... Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent. *George G. Zhanel. 1,4,6. , ... Zhanel, G.G., Cheung, D., Adam, H. et al. Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent. Drugs 76, 567-588 ...

https://link.springer.com/article/10.1007/s40265-016-0545-8?error=cookies_not_supported&code=873ede04-4e33-47f6-876e-0ae59305a1b5

... namely selection for and spread of resistance across multiple bacterial species, and the detrimental effect they can have upon ... While broad spectrum antibiotics play an invaluable role in the treatment of bacterial infections, there are some drawbacks to ... If the causative agent of the infection is known, the use of narrow-spectrum antibacterial agents has the potential to mitigate ... Narrow-spectrum antibacterial agents R. J. Melander, D. V. Zurawski and C. Melander, Med. Chem. Commun., 2018, Advance Article ...

http://pubs.rsc.org/en/content/articlelanding/2018/md/c7md00528h/unauth

Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and ... Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. This review aims to ... In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. ... diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial ...

https://www.mdpi.com/1420-3049/20/5/8856

During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has ... The emergence of bacterial resistance to commercial antibiotics is an issue of global importance. ... The emergence of bacterial resistance to commercial antibiotics. is an issue of global importance. During the last two decades ... antibacterial agents. M. Patra, G. Gasser and N. Metzler-Nolte, Dalton Trans., 2012, 41, 6350 DOI: 10.1039/C2DT12460B ...

https://pubs.rsc.org/en/Content/ArticleLanding/2012/DT/c2dt12460b

Antibiotics remain the number one treatment method for bacterial agents, however, natural options do have some antibacterial ... Another potential natural anti-bacterial agent is oil derived from oregano. Recent studies conducted at Georgetown University ... Antibiotics remain the number one treatment method for bacterial agents, however, natural options do have some antibacterial ... there are some naturally occurring anti-bacterial agents which show promise, as well as one that should be avoided. ...

http://www.nutralegacy.com/blog/general-healthcare/a-few-natural-anti-bacterial-agents/

... improved VS antibacterial activity presumably via instability of the cell wall and enhanced transport of VS through bacterial ... Nonselective Mevalonate Kinase Inhibitor as a Novel Class of Antibacterial Agents. Mohammad Gharehbeglou,1 Ghasem Arjmand,2 ... Antibacterial effect of VS alone and in combination with glycine or EDTA was assessed on Escherichia coli and Pseudomonas ... Antibacterial effect of VS on E. coli was observed at higher concentration (both MLC and MIC were 8 mg/mL). However, ...

https://www.hindawi.com/journals/cholesterol/2015/147601/

All bacterial strains were grown in the presence of low concentrations (sub-minimum inhibitory concentrations or MICs) of ... Investigational Antibacterial Agent REP3123 Prevents Sporulation In Clostridium difficile. By Armen Hareyan G+ Sep 21 2007 - 4: ... REP3123 is a new narrow spectrum antibacterial agent that in vitro prevents the growth of C. difficile by in hibiting an ... Replidynes antibacterial candidate REP3123 is shown to in hibit growth and prevent spore-forming of the Gram-positive ...

https://www.emaxhealth.com/94/16253.html

... antibacterial,agent?,biological,biology news articles,biology news today,latest biology news,current biology news,biology ... New antibacterial strategies are needed because more and more bacteria...In the study which appears online on March 15 in ... Ga also prevented P. aeruginonsa forming biofilms, the multi-cellular bacterial communities responsible for chronic bacterial ... Gallium: A new antibacterial agent?. New antibacterial strategies are needed because more and more bacteria...In the study ...

http://www.bio-medicine.org/biology-news/Gallium-3A-A-new-antibacterial-agent-3F-4815-1/

... produced by a wide range of bacteria and which seem to play an important role in mediating competition within bacterial ... produced by a wide range of bacteria and which seem to play an important role in mediating competition within bacterial ... Common occurrence of antibacterial agents in human intestinal microbiota. Fatima Drissi, Sylvain Buffet, Didier Raoult and ... Citation: Drissi F, Buffet S, Raoult D and Merhej V (2015) Common occurrence of antibacterial agents in human intestinal ...

https://www.frontiersin.org/articles/10.3389/fmicb.2015.00441/full

Bacterial peptide deformylase, which catalyzes the removal of the N-formyl group from N-terminal methionine following ... However, agents to the present have suffered from major potential liabilities. Their in vitro activity has been limited to gram ... further pursuit of more potent and broader spectrum PDIs which are less susceptible to bacterial mechanisms of resistance is ... resistance after the entry of every new antimicrobial into the marketplace necessitates a constant supply of new agents to ...

https://www.dovepress.com/drug-forecast-ndash-the-peptide-deformylase-inhibitors-as-antibacteria-peer-reviewed-article-TCRM-recommendation1

... nano silver antibacterial agent online Wholesalers - choose nano silver antibacterial agent from 118 list of China nano silver ... Nano Silver Antibacterial Masterbatch , Injection Plastic PET PP Masterbatch ... of bacterial seeds. product: 1. Antibacterial ... fabric antibacterial agent , antibacterial agent , antibacterial agents , natural antibacterial agents , food antibacterial ... Nano siliver antibacterial agent and other antibacterial agent ...Nano siliver antibacterial agent and other antibacterial ...

http://www.burrillandco.com/buy-nano-silver-antibacterial-agent

... for Development of Therapeutics against Bacterial Pathogens" to discuss details and critical parameters of various PK/PD ... Considerations for Dose Selection and Clinical Pharmacokinetics/Pharmacodynamics for the Development of Antibacterial Agents In ... Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases CTX-M is the most prevalent family of ... FDA Public Workshop Summary: Advancing Animal Models for Antibacterial Drug Development The U.S. Food and Drug Administration ( ...

https://aac.asm.org/keyword/antibacterial

Therefore, inhibitors of DNA primase could provide antibiotic agents. Compounds that inhibit bacterial DnaG primase have been ... Bacterial primases have a markedly different structure than the human primase. Inhibition of primase activity is expected to ... The bacterial primase-an essential component in the replisome-is a promising but underexploited target for novel antibiotic ... selectively halt bacterial DNA replication. Evidence is growing that halting DNA replication has a bacteriocidal effect. ...

https://www.mdpi.com/2079-6382/7/3/72

In this study, we report that the iodo-thiocyanate complex (ITC) is an effective bactericidal agent with activity against ... In this study, we report that the iodo-thiocyanate complex is an effective bactericidal agent with activity against planktonic ... Agarose Gel Electrophoresis to Detect Bacterial DNA Damage. The potential of ITC as an agent that would induce bacterial DNA ... Antibacterial Potential of an Antimicrobial Agent Inspired by Peroxidase-Catalyzed Systems. Lilit Tonoyan1*, Gerard T. A. ...

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00680/full

Anti-bacterial potency * Laboratory investigations * Clinical observations * Adverse reactions * Practical aspects of using ... Anti-bacterial potency. Honey is produced from many different floral sources and its antimicrobial activity varies with origin ... Honey as a topical antibacterial agent for treatment of infected wounds Author(s) ... The antibacterial activity of honey. 1.The nature of the antibacterial activity. Bee World 1992; 73(1): 5-28.. 3. Brady NF, ...

http://www.worldwidewounds.com/2001/november/Molan/honey-as-topical-agent.html

The susceptibility of five bacterial species to seven dentinal bonding agents was examined in vitro. Agar diffusion tests using ... No antibacterial effect was noted for Prisma Universal Bond 2 and Superlux Universal Bond 2 systems. The primers of Gluma, ... No inhibition was seen after these resins were cured, whereas the antibacterial effect of XR-Bond on S sanguis and A viscosus ... Of all the compounds tested, Gluma cleanser and Gluma etchant showed the strongest growth inhibition for all bacterial strains ...

http://www.quintpub.com/journals/qi/abstract.php?iss2_id=864&article_id=9888&article=12&title=Antibacterial%20activity%20of%20dentinal%20bonding%20agents

High-throughput identification of chemical inhibitors of E. coli Group 2 capsule biogenesis as anti-virulence agents. Goller ... Lantos, Paul (Expert Rev Anti Infect Ther, 2011-07). The diagnosis of chronic Lyme disease has been embroiled in controversy ... Changing epidemiology of serious bacterial infections in febrile infants without localizing signs. Watt, K; Waddle, E; ... BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition with estimated 30% mortality. Clinical ...

https://dukespace.lib.duke.edu/dspace/browse?type=subject&value=Anti-Bacterial%20Agents

7 were observed as good antibacterial agents and compound 7 was found to be the most active against all the selected bacterial ... IV) QSAR Model for Antibacterial Activity against Enterococcus faecalis:. The observed and predicted antibacterial activity of ... III) QSAR Model for Antibacterial Activity against Pseudomonas aeruginosa:. The observed and predicted antibacterial activity ... II) QSAR Model for Antibacterial Activity against Staphylococcus aureus:. The observed and predicted antibacterial activity of ...

https://www.hindawi.com/journals/tswj/2014/732141/

Researchers have discovered that some of the carbohydrates in human milk not only possess antibacterial properties of their own ... Tags: bacterial infections, milk, proteins, nutrition, antibiotic resistance, bacteria , Industry News, Product Resource: ... Sugars in Human Mothers Milk Are Non-Toxic Antibacterial Agents. Sugars in Human Mothers Milk Are Non-Toxic Antibacterial ... exposing more of the bacteria to attack by antibacterial agents.Image credit: Steven Townsend / VanderbiltTo do so, the ...

https://www.labmanager.com/news/2017/08/sugars-in-human-mother-s-milk-are-non-toxic-antibacterial-agents

The antibacterial activity of the oils was tested against standard strain Escherichia coli ATCC 25922 as well as 60 other ... The considerable therapeutical problems of persistent infections caused by multidrug-resistant bacterial strains constitute a ... continuing need to find effective antimicrobial agents. The aim of this study was to demonstrate the activities of basil ( ... infections caused by multidrug-resistant bacterial strains constitute a continuing need to find effective antimicrobial agents ...

http://mdpi.com/1420-3049/18/8/9334

Cubist is currently developing IV and oral formulations of daptomycin to treat serious bacterial infections. In vitro data show ... Pharmaceuticals and Gilead Sciences Announce European Commercialization Agreement for Investigational Antibacterial Agent ... fungal and bacterial infections) and cancer. Gilead maintains research, development or manufacturing facilities in Foster City ... development and commercialization of novel antimicrobial drugs to combat serious and life-threatening bacterial and fungal ...

http://www.gilead.com/news/press-releases/2001/1/cubist-pharmaceuticals-and-gilead-sciences-announce-european-commercialization-agreement-for-investigational-antibacterial-agent-cidecin

He was able to detect over 100 different bacterial growths from the specimens. The thing is not all the bacteria were harmful. ... "which may support bacterial colonization and proliferation," according to the BBC. ...

https://worldtruth.tv/beards-the-antibacterial-agent-for-men/?amp=1

... an antibacterial, antifungal, and antiviral agent containing the same as the active agent; and an antibacterial, antifungal, ... and antiviral composition containing the above agent and a vehicle or a carrier. The agent has a wide antibacterial and ... Anti-bacterial color paste material and preparation method thereof CN104263035B (en) * 2014-09-24. 2016-08-31. 苏州冰心文化用品有限公司. ... US5792793A - Antibacterial, antifungal and antiviral agent - Google Patents. Antibacterial, antifungal and antiviral agent ...

https://patents.google.com/patent/US5792793A/en

... which can be used as antibacterial agents. Compounds described herein can be used for treating or preventing conditions caused ... can be useful as antibacterial agents for treating bacterial infections in a patient in need thereof, for example, in a human ... emulsifying agents, suspending agents, sweetening agents, flavouring agents, perfuming agents or mixtures thereof. ... However, there remains a need for novel ketolide derivatives, which can be used as antibacterial agents on a wide variety of ...

https://www.sumobrain.com/patents/wipo/Ketolide-derivatives-as-antibacterial-agents/WO2007060518A2.html

Antimicrobial Agents Lisette Vazquez October 27, 2013 Antimicrobial Agents Antimicrobial agents are utilized to kill microorganisms that cause infections. (bartleby.com)
The purpose of this paper is to explore the different types of antimicrobial agents and the differences between viral and bacterial infections. (bartleby.com)
Tetracyclines are broad-spectrum antibacterial agents that have been useful in the treatment of a variety of infections ranging from community-acquired respiratory tract infections to less severe conditions such as acne [ 1 , 2 ]. (springer.com)
Unfortunately, their widespread use in human and veterinary medicine as well as in agriculture has led to the development of substantial bacterial resistance and subsequently to decreased utility for indications such as intestinal, respiratory, and urinary tract infections [ 3 , 4 ]. (springer.com)
While broad spectrum antibiotics play an invaluable role in the treatment of bacterial infections, there are some drawbacks to their use, namely selection for and spread of resistance across multiple bacterial species, and the detrimental effect they can have upon the host microbiome. (rsc.org)
Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. (mdpi.com)
While antibiotics are still the best treatment for very serious bacterial infections, there are some naturally occurring anti-bacterial agents which show promise, as well as one that should be avoided. (nutralegacy.com)
However, colloidal silver (a liquid containing silver particles) products are on the market today as supplements that will supposedly fight several types of bacterial infections. (nutralegacy.com)
In preclinical studies, REP3123 was superior to two agents widely used to treat C. difficile infections, vancomycin and metronidazole, in preventing the organism from forming spores. (emaxhealth.com)
New antibacterial strategies are needed because more and more bacteria are antibiotic resistant and because antibiotics are not effective at eradicating chronic bacterial infections. (bio-medicine.org)
Ga also prevented P. aeruginonsa forming biofilms, the multi-cellular bacterial communities responsible for chronic bacterial infections, and killed both free-living bacteria and bacteria in biofilms. (bio-medicine.org)
Changing epidemiology of serious bacterial infections in febrile infants without localizing signs. (duke.edu)
Mother's milk, which consists of a complex and continually changing blend of proteins, fats and sugars, helps protect babies against bacterial infections. (labmanager.com)
The considerable therapeutical problems of persistent infections caused by multidrug-resistant bacterial strains constitute a continuing need to find effective antimicrobial agents. (mdpi.com)
Cubist is currently developing IV and oral formulations of daptomycin to treat serious bacterial infections. (gilead.com)
Cubist Pharmaceuticals is focused on becoming a global leader in the research, development and commercialization of novel antimicrobial drugs to combat serious and life-threatening bacterial and fungal infections. (gilead.com)
Also provided are processes for preparation of compounds described herein, pharmaceutical compositions thereof, and methods of treating bacterial infections. (sumobrain.com)
Cell envelope-active agents, particularly β-lactams, play a pivotal role in the treatment of bacterial infections and the extent to which their activity is affected by the emergence of multidrug-resistant organisms is of concern. (wiley.com)
Participants in this course will be introduced to evidence-based information related to the microbiology of odontogenic infections, the pharmacology of systemic antibacterial agents, and the rationale for the selection of an antibacterial agent for the treatment of odontogenic infections and for prophylactic therapy. (dentalcare.com)
Cotton textiles modified with citric acid as efficient anti-bacterial agent for prevention of nosocomial infections. (sigmaaldrich.com)
When antibacterial agents are used appropriately to treat complicated odontogenic infections or to prevent infections in high-risk patients, clinicians must accept the ecological consequences of antibacterial chemotherapy. (dentalcare.com)
However, when other therapeutic means are available, antibacterial agents should not be routinely prescribed to treat or to prevent infections. (dentalcare.com)
But he does recommend the antibacterial soap for patients with recurrent skin infections and says it helps to reduce bacteria colony counts. (baltimoresun.com)
Description Bacterial infections pose a major health concern worldwide, and the emergence of multi-drug resistant strains of bacteria has intensified the search for new antibiotic treatments with novel mechanisms of action. (rutgers.edu)
The use of metal ions to control bacterial infections remains of interest as drug-resistant bacteria are becoming increasingly common and dangerous to human health," Dr. Chung said. (washington.edu)
Severe bacterial infections represent an ever-increasing threat worldwide, which is aggravated by the continued appearance of multi-resistant bacteria and the lack of efficious antidotes. (ascenion.de)
Non-systemic bacterial infections causing chronic inflammations do represent a particular challenge for public health systems, emphasizing the urgent need for new therapeutic treatment options. (ascenion.de)
2018) Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds. (ascenion.de)
Tetracycline is used to treat many different bacterial infections, such as u. (rpsi.ir)
This review provides a narrative summary of anti-sense therapies, an approach to managing bacterial infections by pursuing specific molecular targets that disrupt the flow of information from deoxyribonucleic acid to ribonucleic acid to protein, leading to the loss of bacterial functions. (cdc.gov)
The discovery of the sulfonamides, the rst drugs to control systemic bacterial infections, had its origin in the investigation of organic dyes for chemotherapeutic purposes initiated by Paul Ehrlich and others in the rst decade of the 1900s. (scribd.com)
Antibacterial agent delivery is of great importance in medicine and dentistry since the bacterial infections are still one of the major reasons for hospitalization and mortality. (qmul.ac.uk)
Despite of the development of technique and pharmacy, more antimicrobial agents are optimized and utilized to treat infections, and their action of principal is better understood which lay a foundation for developing strategies for infection treatment. (qmul.ac.uk)
Antibacterial agents (ABAs) contribute significantly to reduce morbidity and mortality of bacterial infections as well as play a crucial role in the success of major advances in medicine such as organ transplants, advanced surgeries, cancer chemotherapy and cardiac surgery. (sljol.info)
β-lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. (wikipedia.org)

2014). The bacteria would release a bacterial enzyme that would bind to a substrate released by your body and start a chemical reaction infecting the cells with the bacteria it holds. (bartleby.com)
Triclosan specifically blocks the bacteria from binding to the active site on the enzyme ("What Makes Antibacterial Soap Antibacterial? (bartleby.com)
Antibacterials are compounds that interfere with the growth and reproduction of bacteria, and can be used to disinfect surfaces in the home. (newscientist.com)
Any product that claims to kill bacteria will contain chemicals that are antibacterial. (newscientist.com)
This review outlines the advantages and challenges of narrow-spectrum antibacterial agents, discusses the progress that has been made toward developing diagnostics to enable their use, and describes some of the narrow-spectrum antibacterial agents currently being investigated against some of the most clinically important bacteria including Clostridium difficile , Mycobacterium tuberculosis and several ESKAPE pathogens. (rsc.org)
The garlic derived agent could also turn up in antibacterial soaps and other similar products as a tool to combat the spread of bacteria. (nutralegacy.com)
Hydramacin works by sticking to the bacterial surface, promoting the clumping of nearby bacteria, then disrupting the bacterial membrane. (infectioncontroltoday.com)
This study was conducted to assess antibacterial effects of vanadyl sulfate (VS), one of the mevalonate kinase inhibitors to find a new target for killing bacteria. (hindawi.com)
Antibacterial effect of VS alone and in combination with glycine or EDTA was assessed on Escherichia coli and Pseudomonas aeruginosa as Gram-negative and Staphylococcus aureus and Enterococcus faecalis as Gram-positive bacteria using serial dilution method and minimum inhibitory concentrations (MICs) identified. (hindawi.com)
New antibacterial strategies are needed because more and more bacteria. (bio-medicine.org)
One approach to developing new antibacterial strategies, taken by researchers from the University of Washington, Seattle, is to limit the amount of iron (Fe), which is critical for bacterial growth, to which bacteria have access. (bio-medicine.org)
Bacteriocins are a diverse group of natural ribosomally synthesized antimicrobial peptides produced by a wide range of bacteria and which seem to play an important role in mediating competition within bacterial communities. (frontiersin.org)
bacteria, until all the bacteria have been eliminated, therefore, the silver nano particles are long-actingantibacterial agent . (burrillandco.com)
In this study, we report that the iodo-thiocyanate complex (ITC) is an effective bactericidal agent with activity against planktonic and biofilm cells of Gram-negative ( Escherichia coli and Pseudomonas aeruginosa ) and Gram-positive ( Staphylococcus aureus and methicillin-resistant S. aureus ) bacteria. (frontiersin.org)
In an experimental study conducted on burns created on the skin of pigs [25] , there were fewer bacterial colonies seen histologically in wounds treated with honey compared with those treated with sugar, fewer micro-pustules in the neo-epidermis, and fewer bacteria seen in the eschar of the honey-treated wounds. (worldwidewounds.com)
In the present work, novel series of seven benzamide substituted Mannich bases are prepared and further screened for the antibacterial activity against Gram negative bacteria ( Escherichia coli, Pseudomonas aeruginosa ) and Gram positive bacteria ( Enterococcus faecalis, Staphylococcus aureus ). (hindawi.com)
The image of the right shows that the biofilm breaks down when a Strep culture is dosed with human milk sugars, exposing more of the bacteria to attack by antibacterial agents. (labmanager.com)
So far, two broke down the bacterial biofilms and killed the bacteria, four broke down the biofilms but did not kill the bacteria and two killed the bacteria without breaking down the biofilms. (labmanager.com)
While the resistance of bacteria to traditional antibiotics is a major public health concern, the use of extremely potent antibacterial agents is limited by their lack of selectivity. (asm.org)
A similar immunotargeting of bacteria is not feasible due to the lack of a bacterial internalization process, making the use of an extracellular release mechanism necessary for a targeted antibacterial approach. (asm.org)
Janet Donohue, spokeswoman for the Soap and Detergent Association, explains that antibacterial soaps contain ingredients - the most common is triclosan - that actually kill the bacteria and leave a residue that helps keep bacteria from recurring. (baltimoresun.com)
In this study, we investigated the antibacterial effects of bilirubin on certain Gram-negative bacteria using both agar dilution and liquid microdilution methods. (alliedacademies.org)
Thus, we explored this topic by measuring the antibacterial effects of bilirubin on certain Gram-negative bacteria using both agar dilution and liquid microdilution methods. (alliedacademies.org)
Bacterial cell division remains a new, currently untargeted pathway making it highly desirable research area for discovering new ways to kill bacteria. (rutgers.edu)
Reducing the quantitative level of bacterial contamination in an open, acute or chronic, soft tissue wound below the critical level of 10(5) bacteria per gram of viable tissue is essential to delayed primary closure. (semanticscholar.org)
Recent studies convincingly showed that Pep19-2.5 (Aspidasept), a synthetic antimicrobial, anti-inflammatory and endotoxin-neutralizing peptide, efficiently neutralizes pathogenicity factors of Gram-negative and Gram-positive bacteria and protects against sepsis. (ascenion.de)
There is an urgent need for antibacterial medications and compositions containing these funds, which are effective against common oral pathogens and skin bacteria. (russianpatents.com)
Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. (medchemexpress.com)
There are data demonstrating that anti-sense therapies are capable of killing bacteria, silencing antimicrobial resistance mechanisms to restore sensitivity to conventional antibiotic agents, and to target virulence pathways such as biofilm production. (cdc.gov)
The evolution of pathogenic bacteria against commercially available antimicrobial agents has become a critical problem in modern era. (ijcmas.com)
Naturally occurring antibacterial agents are not able to overcome bacterial resistance, while Bacteriophages have a higher mutation and replication rate, so they can compete over the development of resistance of bacteria against antimicrobial agents. (ijcmas.com)
The bacteria-killing agent is added to a growing list of everyday consumer products, including liquid soaps, hand sanitizers, cosmetics, laundry soap and pesticides. (absolute-health.org)

In particular a normalized minimum inhibitory concentration as low as 6.25 μg mL −1 for the bacterial strains was recorded for C2 . (uclouvain.be)
Saudi honey inhibit the growth of bacterial strains and that honey can be used as complementary antimicrobial agent. (greenmedinfo.com)
However, the overuse of antibiotics has made them less effective and has led to the development of some antibiotic-resistant bacterial strains. (nutralegacy.com)
All bacterial strains were grown in the presence of low concentrations (sub-minimum inhibitory concentrations or MICs) of either REP3123, vancomycin or metronidazole. (emaxhealth.com)
At 0.5 times the MIC, REP3123 was the most effective agent at preventing the production of spores in all strains (equal to or less than 1% of spores after 96 hours of treatment). (emaxhealth.com)
Of all the compounds tested, Gluma cleanser and Gluma etchant showed the strongest growth inhibition for all bacterial strains. (quintpub.com)
The infectious diseases are widely managed by the antimicrobial agents but increase in resistance of microorganisms towards antimicrobial agents in the past few years has become a serious health care problem, and this has led to the necessity of designing of some novel, potent, and safe antimicrobial agents against resistant microbial strains. (hindawi.com)
The antibacterial activity of the oils was tested against standard strain Escherichia coli ATCC 25922 as well as 60 other clinical strains of Escherichia coli . (mdpi.com)
Single-copy gene fusions between the lacZ reporter gene and Escherichia coli strains containing promoters induced by cold shock ( cspA ), cytoplasmic stress ( ibp ), or protein misfolding in the cell envelope (P3 rpoH ) were constructed and tested to determine their ability to detect antibacterial agents while simultaneously providing information on their cellular targets. (asm.org)
Researchers in Italy and Britain have found that the main active ingredient in marijuana - tetrahydrocannabinol, or THC - and related compounds show promise as antibacterial agents, particularly against microbial strains that are already resistant to several classes of drugs. (wordpress.com)
All were effective against several common multiresistant bacterial strains, although, perhaps understandably, the researchers suggested that the nonpsychotropic cannabinoids might prove more promising for eventual use. (wordpress.com)

Are antibacterials the same as antibiotics? (newscientist.com)
Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. (mdpi.com)
The emergence of bacterial resistance to commercial antibiotics is an issue of global importance. (rsc.org)
When we have a bacterial infection, most of us turn to our physicians for a prescription for antibiotics. (nutralegacy.com)
Recent studies conducted at Georgetown University have discovered that one of the components of oregano - carvacrol - has been shown to treat bacterial infection as well or better than modern antibiotics. (nutralegacy.com)
Methionyl tRNA synthetase is a novel target that has not been previously exploited by antibiotics and REP3123 shows no cross-resistance to currently marketed antibacterial agents. (emaxhealth.com)
The basic motivation for the research was the growing problem of bacterial resistance to antibiotics, which the Center for Disease Control and Prevention estimates causes 23,000 deaths annually. (labmanager.com)
The increasing development of bacterial resistance to traditional antibiotics has reached alarming levels ( 2 , 3 ), spurring a strong need to develop new antimicrobial agents. (asm.org)
Long-term approaches rely on bacterial and phage genomics to discover new antibiotics that attack new protein targets which are essential to bacterial survival and therefore with no known resistance ( 1 , 8 ). (asm.org)
Bacterial resistance to antibiotics, particularly to multiple antibiotics, is becoming a cause for significant concern. (nih.gov)
Bacterial resistance to present-generation antibiotics is increasing drastically, which has become a major public health concern. (begellhouse.com)
The antibacterial efficiency of the mushroom extract against clinical pathogens, which were found to be multidrug resistant (MDR) to most of the tested antibiotics, was studied. (begellhouse.com)
That is also an important consideration at a time when growing bacterial resistance to antibiotics places greater urgency on the need to find antimicrobial alternatives, she noted. (washington.edu)
Before antibiotics, medical science had very little to offer a patient who was suffering from a bacterial infection. (coolwellbeing.org)
Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used group of antibiotics. (wikipedia.org)
β-lactam antibiotics are bactericidal, and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. (wikipedia.org)

During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has steadily declined and failed to meet the challenges posed by rapidly increasing resistance of the pathogens against common antibacterial drugs . (rsc.org)
In June 2017, The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, organized a workshop entitled "Pharmacokinetics-Pharmacodynamics (PK/PD) for Development of Therapeutics against Bacterial Pathogens" to discuss details and critical parameters of various PK/PD methods and identify approaches for linking human pharmacokinetic (PK) data and drug efficacy analyses. (asm.org)
Traditionally antibacterial agents have already been considered to haven't any significant therapeutic effect against fungal pathogens. (exposed-skin-care.net)
The current study suggests that the methanolic extract of P. ostreatus can be used as a promising antibacterial agent against MDR bacterial pathogens. (begellhouse.com)
A library of norbornane-based peptide mimetics have been synthesised and shown to exhibit antibacterial activity against a range of troublesome Gram-positive and Gram-negative bacterial pathogens. (edu.au)
These potential therapeutics have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. (psu.edu)
Identified compositions have been demonstrated to kill bacterial pathogens when added exogenously. (psu.edu)

Natural isothiocyanates represent a promising group of natural anti-infective compounds with activity against Pseudomonas aeruginosa biofilms. (greenmedinfo.com)
The antibacterial activity of melilot honey is created by hydrogen peroxide and other bioactive compounds. (greenmedinfo.com)
This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development. (rsc.org)
The compounds 5 , 6 , and 7 were found to be the most active antibacterial agents among all the synthesized compounds. (hindawi.com)
Unfortunately, although successfully obtaining analogs with good antibacterial activity, these compounds lacked desired solubility properties for further advancement. (rutgers.edu)
This led to the second generation of compounds that lacked a constitutive cationic charge while retaining the antibacterial activity seen with the previous analogs. (rutgers.edu)
Compounds from the second generation were found to be highly protein bound resulting in a significant loss of antibacterial activity when administered in the presence of protein. (rutgers.edu)
These findings emphasize and validate the previous work of others and identify the most effective CAM anti-inflammatory, antibacterial compounds using these models. (biomedcentral.com)
Both compounds possess antimicrobial and anti-inflammatory activity and are capable of efficiently neutralizing bacterial endotoxins. (ascenion.de)
Both compounds inhibit the bacterial endotoxin-induced maturation and migration of monocyte-derived dendritic cells (MoDCs), thereby prevending sustained and excessive inflammatory responses, which otherwise contribute to chronic inflammation and delayed wound healing. (ascenion.de)
Our lead compounds were then screened for anti-inflammatory activity. (elsevier.com)
With this in mind, the work covered in this thesis focused on the preparation of novel carbohydrate-based compounds as potential anti-bacterial agents, in particular targeted to mycobacterial infection. (edu.au)
For the purpose of investigating the requirement for a galactofuranose glycan moiety for anti-bacterial activity, the aglycons of the more active galactofuranosyl compounds (Chapter 2) were introduced onto alternate furanose sugars. (edu.au)
This series of compounds (containing either sulfenamide or sulfonamide functionality) were prepared to investigate the requirement of a carbohydrate moiety for anti-bacterial activity. (edu.au)
But the compounds may prove useful sooner as a topical agent against methicillin-resistant Staphylococcus aureus, or MRSA , to prevent the microbes from colonizing on the skin. (wordpress.com)
All the newly synthesized compounds were screened for its in vitro antibacterial activity against Pseudomonus aerugninasa, Straphylococcus aureus and E. coli using Gentamicin and tetracycline as a reference standard by paper disc diffusion method. (rroij.com)

Inhibition of the isoprenoid pathway might provide new tools to overcome bacterial resistance. (hindawi.com)
Peroxidase-catalyzed oxidation of (pseudo)halides yields reactive agents which oxidize microorganisms, damaging essential structural and functional components and causing inhibition of microbial metabolism and growth ( Thomas and Fishman, 1986 ). (frontiersin.org)
No inhibition was seen after these resins were cured, whereas the antibacterial effect of XR-Bond on S sanguis and A viscosus was not affected by light curing. (quintpub.com)
Traditional methods for screening potential antimicrobial agents rely on inhibition of bacterial growth and often require high concentrations of the compound being tested. (asm.org)
As a result, substances that possess antibacterial activity but are found in concentrations that are too low to cause growth inhibition may be overlooked. (asm.org)
Also, the antibacterial sulfones, eg, dapsone [80-08-8] (4), are believed to act in a similar fashion on enzymes involved with synthesis of folic acid, leading to bacterial growth inhibition. (scribd.com)

Are there any other natural anti-viral substances anyone can share? (nutralegacy.com)
As in cancer therapy, antibacterial targeted therapy could provide an opportunity to reintroduce toxic substances to the antibacterial arsenal. (asm.org)
The patent culminates several years of work in which the group studied a novel class of substances called titanates and peroxotitanates, which can inhibit bacterial growth when bound to metal ions. (washington.edu)
A more responsive antibacterial agent delivery system, which can release the active substances on demand to match the stages of diseases, is highly desirable. (qmul.ac.uk)

2. The series of products integrate safe and efficient inorganic antibiotic agent with unique slow-release technology. (himfr.com)
As an example for a potential systemic use for potent agents that are limited for topical use, we present antibody-targeted phage nanoparticles that carry a large payload of the hemolytic antibiotic chloramphenicol connected through the aminoglycoside neomycin. (asm.org)
What are 5 main antibiotic targets in a bacterial cell? (brainscape.com)
As a result of antibiotic use and misuse, bacterial drug resistance has become an increasing concern in human medicine. (asm.org)
Conventional antibiotic agents are overused, leading to decreased efficacy because of a rising incidence in antimicrobial resistance. (cdc.gov)
Further, conventional antibiotic agents result in widespread effects to human microbiota, which can lead directly to adverse events such as Clostridium difficile infection. (cdc.gov)
Anti-sense therapies show promise as a new class of antibiotic agents, providing molecular precision that leads to specific targeting of bacterial species and bacterial functions, including virulence mechanisms beyond the reach of current antibiotic agents. (cdc.gov)
Further, changing the sequence of an anti-sense oligonucleotide provides a method of dealing with antimicrobial resistance that is more time- and cost-flexible than the available options with current conventional antibiotic agents. (cdc.gov)
Immunologically mediated adverse reactions to any β-lactam antibiotic may occur in up to 10% of patients receiving that agent (a small fraction of which are truly IgE-mediated allergic reactions, see amoxicillin rash). (wikipedia.org)

The use of triclosan (the anti-bacterial agent) in soaps over the years, has negatively effected the environment. (thepetitionsite.com)
If new regulations are put into action manufacturing companies companies will have to prove the effectiveness of antibacterial soaps over water and soap. (bartleby.com)
Antibacterial Soap Dial antibacterial soap advertises that it is "over 10x more effective at killing disease-causing germs than ordinary liquid hand soaps"(1). (bartleby.com)
Various studies suggest that antibacterial soaps can be harmful and may lead to problems like super bugs, dry skin, and hand eczema. (bartleby.com)
Soaps: Antibacterial agents may be no better than a good scrubbing. (baltimoresun.com)
Do we really need antibacterial soaps (and household cleaners and sponges) the way all the marketers tell us? (baltimoresun.com)
Her hospital follows the guidelines of the Association for Practitioners of Infection Control, which recommends using antibacterial soaps in neonatal intensive-care units, critical-care units and operating rooms. (baltimoresun.com)
The Food and Drug Administration, which regulates antibacterial soaps, has convened an advisory committee to address the soap question. (baltimoresun.com)
Expert assails overuse of anti-bacterial soaps He fears. (baltimoresun.com)
The antimicrobial agent triclosan is used in consumer products including liquid soaps, hand sanitizers, cosmetics, laundry soap and pesticides. (absolute-health.org)

Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. (mdpi.com)
Photo credit: Zack Eagles / Vanderbilt By dosing strep cultures with a mixture of milk sugars and antimicrobial peptides from human saliva, the researchers also showed that the sugars' ability to break down biofilms can also enhance the effectiveness of the other antimicrobial agents that breast milk contains. (labmanager.com)

REP3123 is a new narrow spectrum antibacterial agent that in vitro prevents the growth of C. difficile by in hibiting an essential enzyme inthe bacterial cell called methionyl tRNA synthetase, which blocks the organism from synthesizing proteins. (emaxhealth.com)
The susceptibility of five bacterial species to seven dentinal bonding agents was examined in vitro. (quintpub.com)
The synthesized derivatives were authenticated by TLC, UV-Visible, FTIR, NMR, and mass spectroscopic techniques and further screened for in vitro antibacterial activity by test tube dilution method using amoxicillin and cefixime as standard drugs. (hindawi.com)
Bilirubin had no in vitro antibacterial effect on E. coli, K. pneumoniae, A. baumannii, or P. aeruginosa. (alliedacademies.org)
For robust screening, we developed an in-vitro efficacy paradigm to ensure anti-inflammatory parameters were observed independent of cytotoxicity. (biomedcentral.com)
In vitro fluoride release and the antibacterial effect of glass ionomers containing chlorhexidine gluconate. (semanticscholar.org)
In assays against M. smegmatis the Galf 9-heptadecyl thioglycoside was found to be the most active compound with an in vitro potency of 1 µg/mL, comparable to the frontline anti-TB drug ethambutol (1-4 µg/mL). (edu.au)
In addition, the thioglycoside displayed excellent broad spectrum Gram positive anti-bacterial activity in vitro, but was not active at concentrations below 64 µg/mL against a Gram negative organism. (edu.au)

the term 'inhibine number' was coined as a measure of the relative antibacterial potency of different honeys, it being the number of steps by which a honey could be diluted and still inhibit bacterial growth [24] . (worldwidewounds.com)

It is not surprising that some of the enzymes involved in isoprenoids biosynthesis could be targets for the development of novel antibacterial agents. (hindawi.com)
Since the early steps of isoprenoid biosynthesis pathway (mevalonate kinase) in eukaryotes resemble bacterial isoprenoid biosynthesis and regarding the fact that VS inhibits the mevalonate pathway in eukaryotic organisms [ 10 ], we examined the effect of VS as a nonselective mevalonate kinase inhibitor on bacterial isoprenoid biosynthesis and its impact on bacterial growth. (hindawi.com)

Gram-negative bacterial agents of sepsis were divided into four test groups according to their species. (alliedacademies.org)
Fruit extracts of both species displayed good broad spectrum antibacterial activity although S. australe extracts generally had greater efficacy than the S. leuhmannii extracts. (edu.au)
A better understanding of AMP-specific resistance demands studying multiple AMPs in a range of bacterial species. (nature.com)
The number of PBPs varies between bacterial species. (wikipedia.org)

Which antibacterial agent(s) would be effective in the therapy of Mr BT's urinary tract infection? (bartleby.com)
In a neutropenic murine thigh infection model, the pharmacodynamic parameter that demonstrated the best correlation with antibacterial response was the ratio of area under the plasma concentration-time curve over 24 h to the minimum inhibitory concentration (AUC 0-24h /MIC). (springer.com)
If the causative agent of the infection is known, the use of narrow-spectrum antibacterial agents has the potential to mitigate some of these issues. (rsc.org)
The current protocols and initiatives in infection control could be improved by the use of antimicrobial agents applied on cotton carbohydrate polymer. (sigmaaldrich.com)
Roxithromycin enhances the adhesive and chemotactic functions of these cells which in the presence of infection produce phagocytosis and bacterial lysis. (pharmacycode.com)
The Canadian Medical Association has called upon the federal government to ban the sale of household antibacterial products due to the risk of bacterial resistance and to recognize that soap and alcohol-based solutions are just as effective in preventing household infection. (absolute-health.org)

Such combination strategy could be broadly applicable to the improvement of existing antimicrobial methods or design/discover new effective antimicrobial agents/methods. (omicsonline.org)

Like other tetracyclines, eravacycline inhibits bacterial protein synthesis through binding to the 30S ribosomal subunit. (springer.com)
Bacterial peptide deformylase, which catalyzes the removal of the N-formyl group from N-terminal methionine following translation, is essential for bacterial protein synthesis, growth, and survival. (dovepress.com)

To prevent bacterial contamination between implant/abutment, different types of gels and ointments inside of implants are commonly used. (austinpublishinggroup.com)

With minimal projected side-effects, owing to the lack of Galf residues in mammalian systems, hydrolytically-stable Galf analogues were selected as promising targets for the development of potential therapeutic agents against Galf containing pathogenic micro-organisms. (edu.au)

Benzofuran bearing 1,3,5- trisubstituted pyrazoline exhibited antitubercular, antimicrobial and anti-inflammatory activities[19]. (rroij.com)

VS could inhibit the growth of S. aurous and E. coli , and adding glycine or EDTA improved VS antibacterial activity presumably via instability of the cell wall and enhanced transport of VS through bacterial cell wall. (hindawi.com)
Replidyne's antibacterial candidate REP3123 is shown to in hibit growth and prevent spore-forming of the Gram-positive Clostridium difficile (C. difficile) bacterium without inhibiting other key organisms that are essential for normal intestinal functioning. (emaxhealth.com)
LOUISVILLE, Colo., September 19, 2007 /PRNewswire-FirstCall/ -- Replidyne, Inc. announced today that in preclinical studies, its antibacterial candidate REP3123 is shown to inhibit growth and prevent spore-forming of the Gram-positive Clostridium difficile (C. difficile) bacterium without inhibiting other key organisms that are essential for normal intestinal functioning. (drugs.com)
Honeys selected to have a median level of antibacterial activity have been found to prevent growth of Staphylococcus aureus if diluted by a further 7-14 fold beyond the point where their osmolarity ceases to be inhibitory [20] . (worldwidewounds.com)
After incubation, zones of inhibited bacterial growth were measured. (quintpub.com)
A blue halo assay was developed to rapidly characterize the modes of action of antibacterial agents by visual inspection, and this assay was used to detect chloramphenicol secreted into the growth medium of Streptomyces venezuelae cultures. (asm.org)
Organic antibacterial agents are often complex toxic bactericides that have strong inhibitory effects on bacterial growth, such as organic acids, essential oils, and bacteriocins. (omicsonline.org)
Titanates could also be used in bandages, skin gels, mouthwashes and toothpaste to limit bacterial growth, said Dr. Whasun Oh Chung, one of the four researchers. (washington.edu)
In this way, can determine which substance has the best antibacterial effect and which concentration should be used inside implants to avoid bacterial growth. (austinpublishinggroup.com)
The government said that triclosan in waste water can interfere with the growth and reproduction of plants and animals in lakes and streams, but that there is no clear link between triclosan and antibacterial resistance, and no evidence that it poses a risk to humans. (absolute-health.org)

This study was undertaken to determine the interaction of tigecycline with 13 select antimicrobial agents against a wide variety of Gram-negative and Gram-positive bacterial isolates. (nih.gov)
Five bacterial isolates were collected from Sagar Hospital in Bangalore, India. (begellhouse.com)

He was able to detect over 100 different bacterial growths from the specimens. (worldtruth.tv)

one common component is called Triclosan ("What Makes Antibacterial Soap Antibacterial? (bartleby.com)
Inorganic agents, such as hypochlorite, alcohol, chlorine dioxide, hydrogen peroxide, triclosan, triclocarban, and some metal ions, are often less toxic and have received more and more recognition in the antibacterial product market in recent years [ 2 , 3 ]. (omicsonline.org)

The major antibacterial action of penicillins is derived from their ability to inhibit a number of bacterial enzymes, namely penicillin-binding proteins (PBPs), that are essential for peptidoglycan synthesis. (asmscience.org)

Honey is an ancient remedy for the treatment of infected wounds, which has recently been 'rediscovered' by the medical profession, particularly where conventional modern therapeutic agents are failing. (worldwidewounds.com)
The importance of the additional antibacterial activity of honey is demonstrated in comparisons between the therapeutic effects of honey and sugar. (worldwidewounds.com)

Antimicrobial peptides (AMPs) are short, structurally diverse peptides with a broad spectrum of antibacterial activities. (nature.com)

2018) Peptide drug stability: The anti-inflammatory drugs Pep19-2.5 and Pep19-4LF in cream formulation. (ascenion.de)

Dong X, Koo Y, Tang Y, Yun Y, Yang L (2015) Superior Antibacterial Activity of Photochemical Synthesized Ag-CNT Composites and their Synergistic Effects in Combination with other Antimicrobial Agents. (omicsonline.org)

Antibacterials can be classified into two main categories: non-residue and residue. (newscientist.com)
Non-residue antibacterials includes familiar disinfectants like alcohols, chlorine and peroxides. (newscientist.com)

Compounding this problem is the fact that no new chemical entity has been approved by the United States Food and Drug Administration for the treatment of bacterial diseases for more than 20 years ( 28 ). (asm.org)
Tickborne rickettsial diseases continue to cause severe illness and death in otherwise healthy adults and children, despite the availability of low-cost, effective antibacterial therapy. (cdc.gov)
This book contains precisely referenced chapters, emphasizing antibacterial agents with clinical practicality and alternatives to synthetic antibacterial agents through detailed reviews of diseases and their control using alternative approaches. (openaccessbooks.com)
The book aims at explaining bacterial diseases and their control via synthetic drugs replaced by chemicals obtained from different natural resources which present a future direction in the pharmaceutical industry. (openaccessbooks.com)

Bacterial suspensions of McFarland turbidity 0.5 were prepared, and 5-μl aliquots were spotted onto the agar plates within circles 5 mm in diameter (final bilirubin concentrations: 5, 10, and 15 mg/dl). (alliedacademies.org)

The Efficacy of Takip-Kohol (Centalla Asiatica) Leaves Extract as an Antibacterial Agent Against Escherichia Coli, Staphylococcus Aureus and Salmonella Enteritidis. (bartleby.com)
The discovery and antibacterial activity of coelomycin, a fully substituted 2,6-dioxo pyrazine, illustrates the application of the Staphylococcus aureus fitness test strategy to natural products discovery. (nih.gov)

Despite these current liabilities, further pursuit of more potent and broader spectrum PDIs which are less susceptible to bacterial mechanisms of resistance is still warranted. (dovepress.com)

Metals have long been known to have antibacterial properties, said Dr. Whasun Oh Chung, but when used in concentrations high enough to be effective, they also carry a risk of toxic side effects. (washington.edu)
Few studies have evaluated the efficiency of various antibacterial gels and its various concentrations. (austinpublishinggroup.com)

Eravacycline is an investigational, synthetic fluorocycline antibacterial agent that is structurally similar to tigecycline with two modifications to the D-ring of its tetracycline core: a fluorine atom replaces the dimethylamine moiety at C-7 and a pyrrolidinoacetamido group replaces the 2-tertiary-butyl glycylamido at C-9. (springer.com)

Honey is one of the most ancient medicinal agents, dating back at least to the Egyptians who used honey to dress wounds. (labroots.com)
The use of a topical antibacterial agent (silver sulfadiazine) on soft-tissue wounds]. (semanticscholar.org)
article{Bocchiotti1990TheUO, title={[The use of a topical antibacterial agent (silver sulfadiazine) on soft-tissue wounds]. (semanticscholar.org)

Plasma membrane agent. (brainscape.com)
AMPs frequently target the bacterial membrane by forming pores on it. (nature.com)

What is the major component of bacterial cell walls? (brainscape.com)

Under normal circumstances, peptidoglycan precursors signal a reorganisation of the bacterial cell wall and, as a consequence, trigger the activation of autolytic cell wall hydrolases. (wikipedia.org)

All nano silver antibacterial agent wholesalers & nano silver antibacterial agent manufacturers come from members. (himfr.com)
We doesn't provide nano silver antibacterial agent products or service, please contact them directly and verify their companies info carefully. (himfr.com)

Further study on the antibacterial effect of combination treatment of AgCNTs with oxidizing antimicrobial agents (NaOCl or H 2 O 2 ) to E. coli cells indicated a partial synergistic or a synergistic effect using the fractional inhibitory concentration (FIC) index test or isololograms. (omicsonline.org)
The inhibitory bioactivity of S. australe and S. leuhmannii fruit extracts against the bacterial panel validate the use by indigenous Australians of S. australe and S. leuhmannii as antiseptic agents and confirms their medicinal potential. (edu.au)

The protein identified by Joachim Grötzinger, Thomas Bosch and colleagues at the University of Kiel, hydramacin-1, is unusual (and also clinically valuable) as it shares virtually no similarity with any other known antibacterial proteins except for two antimicrobials found in another ancient animal, the leech. (infectioncontroltoday.com)
In the past, scientists have concentrated their search for the source of its antibacterial properties on the proteins it contains. (labmanager.com)
However, an interdisciplinary team of chemists and doctors at Vanderbilt University have discovered that some of the carbohydrates in human milk not only possess antibacterial properties of their own but also enhance the effectiveness of the antibacterial proteins also present. (labmanager.com)
FtsZ is a highly conserved, essential bacterial cell division protein that forms the dynamic Z-ring involved in recruitment of other essential proteins and serving as the constricting force for cell division. (rutgers.edu)
The results of the current research have successfully demonstrated that CA changes the bacterial metabolism through interactions with different biochemical families such as proteins, nucleic acids, lipids, and carbohydrates, which needs further validation by proteomics and transcriptomics studies. (uwaterloo.ca)

The invention also relates to an antibacterial composition and treatment methods. (russianpatents.com)
A new series of pyrazoline derivatives (4a-f) has been synthesized by ultrasonication methods and evaluated for its antibacterial and antifungal activity. (rroij.com)

Provided herein are ketolide derivatives, which can be used as antibacterial agents. (sumobrain.com)
As a result of this finding, a study of structure activity relationships (SAR) of galactofuranose derivatives as antibacterial agents has been undertaken. (edu.au)

As β-lactams are a cornerstone of anti-infective therapy, it is important to closely monitor the activity of the agents being used today and to aggressively pursue new strategies that can augment current drugs and thwart ever-emerging β-lactam resistance mechanisms that are continuously encountered. (wiley.com)
Although several drug classes are characterized by the presence of a sulfonamide function, eg, hypoglycemics, carbonic anhydrase inhibitors, saluretics, and tubular transport inhibitors, the antibacterial sulfonamides have become classied as the sulfa drugs. (scribd.com)

4. An antibacterial water treatment agent according to claim 1, wherein the polyethylene is a low-density polyethylene or high-density polyethylene. (patentsencyclopedia.com)
6. An antibacterial water treatment agent according to claim 1, wherein glass beads are contained in the antibacterial water treatment agent by 10 to 30 percent by weight. (patentsencyclopedia.com)

These results suggest that dandelion extracts have potential as antibacterial uropathogenic disease agents. (greenmedinfo.com)
Because of its limited potential for effectiveness and its risks, colloidal silver may not be the best choice for a natural anti-bacterial agent. (nutralegacy.com)
Another potential natural anti-bacterial agent is oil derived from oregano. (nutralegacy.com)
However, agents to the present have suffered from major potential liabilities. (dovepress.com)
Sienkiewicz M, Łysakowska M, Pastuszka M, Bienias W, Kowalczyk E. The Potential of Use Basil and Rosemary Essential Oils as Effective Antibacterial Agents. (mdpi.com)
Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resistance is a major concern. (nature.com)
The first two chapters of the thesis give a general introduction and literature review on the current use of antibacterial agents and the problems concerned, strategies already developed for antibacterial agent delivery, and the potential triggers to induce a smart release. (qmul.ac.uk)

A government study has found that a common anti-bacterial agent found in everything from toothpaste to toys is harmful to the environment, but safe for humans. (absolute-health.org)

We have found that simple physicochemical features dictate bacterial propensity to evolve resistance against AMPs. (nature.com)

Monotherapy having a fluoroquinolone agent was utilized as the infiltrate was little and the program have been indolent. (exposed-skin-care.net)

In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. (mdpi.com)
Honey is produced from many different floral sources and its antibacterial activity varies with origin and processing. (worldwidewounds.com)
Honey selected for clinical use should be evaluated on the basis of antibacterial activity levels determined by laboratory testing. (worldwidewounds.com)
The primers of Gluma, Denthesive, and Scotchbond 2 displayed antibacterial activity that, in some cases, was comparable to that of 0.2% chlorhexidine. (quintpub.com)
Mannich bases have gained importance due to their application in antibacterial activity [ 1 - 3 ]. (hindawi.com)
Antibacterial activity was also remarkable against S. aureus (4.25 log10 by conventional drying, 4.58 log10 by microwave drying) and against P. aeruginosa (1.93 log10 by conventional drying and 4.66 log10 by microwave drying). (sigmaaldrich.com)
Antibacterial activity against P. aeruginosa was higher in samples subjected to microwave than in conventional drying. (sigmaaldrich.com)
Antibacterial activity was reduced after 10 HDLW cycles but the compound was still effective. (sigmaaldrich.com)
This chapter provides an overview of the antibacterial agents currently marketed in the United States, with major emphasis on their mechanisms of action, spectra of activity, important pharmacologic parameters, and toxicities. (asmscience.org)
Although initial attempts at this were unsuccessful, continued efforts are being made to find a FtsZ inhibitor with improved potency, physiochemical properties, and a broader spectrum of antibacterial activity. (rutgers.edu)
In addition, the aglycon units incorporated were designed in order to identify the necessary characteristics for optimum anti-bacterial activity, and included aglycons both aromatic and aliphatic in character. (edu.au)
It shows antibacterial and antifungal activity by contact mechanism. (sarex.com)
The current research, by Giovanni Appendino of the University of the Eastern Piedmont and colleagues and published in The Journal of Natural Products, looked at the antibacterial activity of the five most common cannabinoids. (wordpress.com)
Over the last decades, many delivery systems have been established to deliver bacterial agents and maintain a sustained activity against them. (qmul.ac.uk)
When the chlorhexidine particles were incorporated into electrospun fibers, a sustained antibacterial activity was demonstrated. (qmul.ac.uk)

Anatomy2

Organisms12

Diseases3

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology1

Phenomena and Processes2

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture2

Information Science8

Health Care2

Geographicals1

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. (1/41157)

Modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s. (2/41157)

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (3/41157)

Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. (4/41157)

Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. (5/41157)

Bioterrorism alleging use of anthrax and interim guidelines for management--United States, 1998. (6/41157)

Acinetobacter bacteremia in Hong Kong: prospective study and review. (7/41157)

Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. (8/41157)

Bacteria

Tropaeolaceae

Stereoisomerism

Anti-Bacterial Agents

Minocycline

Microbial Sensitivity Tests

Gram-Positive Bacteria

Anti-Infective Agents

Gram-Negative Bacteria

beta-Lactamases

Bacterial Infections

Drug Resistance, Bacterial

beta-Lactams

Periodicals as Topic

Access to Information

Mevalonate Kinase Deficiency

Journal Impact Factor

Bibliometrics

Publishing

Peer Review, Research

Haemophilus somnus

Clostridium difficile

Spores, Bacterial

Metronidazole

Spores

Vancomycin

Enterocolitis, Pseudomembranous

Gallium

Gallium Radioisotopes

Newspapers

Tooth Preparation

Rosmarinus

Ocimum basilicum

Oils, Volatile

Ocimum

Diterpenes, Abietane

Escherichia coli

Daptomycin

Technology Transfer

Commerce

Quackery

Drug Approval

Intellectual Property

Europe

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods. (1/41157)

Modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of Pseudomonas aeruginosa 18s. (2/41157)

Various forms of chemically induced liver injury and their detection by diagnostic procedures. (3/41157)

Prodigious substrate specificity of AAC(6')-APH(2"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci. (4/41157)

Emergence of vancomycin resistance in Staphylococcus aureus. Glycopeptide-Intermediate Staphylococcus aureus Working Group. (5/41157)

Bioterrorism alleging use of anthrax and interim guidelines for management--United States, 1998. (6/41157)

Acinetobacter bacteremia in Hong Kong: prospective study and review. (7/41157)

Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. (8/41157)

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Broad Spectrum Antibiotics

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Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus...

Bioline International Official Site (site up-dated regularly)

Microbial resistance

Inapropriate use of antibiotics effective against gram positive microorganisms despite restrictive antibiotic policies in ICUs:...

Nosocomial acquisition of methicillin-resistant Staphyloccocus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL) *...