A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Tests involving inhalation of allergens (nebulized or in dust form), nebulized pharmacologically active solutions (e.g., histamine, methacholine), or control solutions, followed by assessment of respiratory function. These tests are used in the diagnosis of asthma.
Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Drugs that are used to treat asthma.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
Measurement of the maximum rate of airflow attained during a FORCED VITAL CAPACITY determination. Common abbreviations are PEFR and PFR.
A short-acting beta-2 adrenergic agonist that is primarily used as a bronchodilator agent to treat ASTHMA. Albuterol is prepared as a racemic mixture of R(-) and S(+) stereoisomers. The stereospecific preparation of R(-) isomer of albuterol is referred to as levalbuterol.
Agents causing the narrowing of the lumen of a bronchus or bronchiole.
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.
Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Antigen-type substances that produce immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Hypersensitivity reactions which occur within minutes of exposure to challenging antigen due to the release of histamine which follows the antigen-antibody reaction and causes smooth muscle contraction and increased vascular permeability.
A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
Measurement of volume of air inhaled or exhaled by the lung.
Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).
Devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments.
The structural changes in the number, mass, size and/or composition of the airway tissues.
Any tests done on exhaled air.
Any hindrance to the passage of air into and out of the lungs.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Any arthropod of the subclass ACARI except the TICKS. They are minute animals related to the spiders, usually having transparent or semitransparent bodies. They may be parasitic on humans and domestic animals, producing various irritations of the skin (MITE INFESTATIONS). Many mite species are important to human and veterinary medicine as both parasite and vector. Mites also infest plants.
An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
The volume of air that is exhaled by a maximal expiration following a maximal inspiration.
Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.
The act of BREATHING out.
A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
Antigens from the house dust mites (DERMATOPHAGOIDES), mainly D. farinae and D. pteronyssinus. They are proteins, found in mite feces or mite extracts, that can cause ASTHMA and other allergic diseases such as perennial rhinitis (RHINITIS, ALLERGIC, PERENNIAL) and atopic dermatitis (DERMATITIS, ATOPIC). More than 11 groups of Dermatophagoides ALLERGENS have been defined. Group I allergens, such as Der f I and Der p I from the above two species, are among the strongest mite immunogens in humans.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Spasmodic contraction of the smooth muscle of the bronchi.
A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.
Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.
Substances that reduce or suppress INFLAMMATION.
Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.
Unsaturated pregnane derivatives containing two keto groups on side chains or ring structures.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Drugs that selectively bind to and activate beta-adrenergic receptors.
The rate of airflow measured during a FORCED VITAL CAPACITY determination.
A biologically active principle of SRS-A that is formed from LEUKOTRIENE D4 via a peptidase reaction that removes the glycine residue. The biological actions of LTE4 are similar to LTC4 and LTD4. (From Dictionary of Prostaglandins and Related Compounds, 1990)
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Species of European house dust mite, in the family PYROGLYPHIDAE. It is the most commonly found house dust mite.
Measurement of rate of airflow over the middle half of a FORCED VITAL CAPACITY determination (from the 25 percent level to the 75 percent level). Common abbreviations are MMFR and FEF 25%-75%.
A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts.
Family of house dust mites, in the superfamily Analgoidea, order Astigmata. They include the genera Dermatophagoides and Euroglyphus.
A group of compounds that are derivatives of beta-methylacetylcholine (methacholine).
A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
A muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antiarrhythmic.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
An adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.
Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A small aerosol canister used to release a calibrated amount of medication for inhalation.
A form of hypersensitivity affecting the respiratory tract. It includes ASTHMA and RHINITIS, ALLERGIC, SEASONAL.
Endoscopic examination, therapy or surgery of the bronchi.
Derivatives of the steroid androstane having two double bonds at any site in any of the rings.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)
Analogs and derivatives of atropine.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
The characteristic three-dimensional shape of a molecule.
Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.
A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.
Antibodies produced by a single clone of cells.
Elements of limited time intervals, contributing to particular results or situations.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
Spirometric technique in which the volume of air breathed in the right and left lung is recorded separately.
The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
The relationship between the dose of an administered drug and the response of the organism to the drug.
A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.
Compressed gases or vapors in a container which, upon release of pressure and expansion through a valve, carry another substance from the container. They are used for cosmetics, household cleaners, and so on. Examples are BUTANES; CARBON DIOXIDE; FLUOROCARBONS; NITROGEN; and PROPANE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
Insects of the order Dictyoptera comprising several families including Blaberidae, BLATTELLIDAE, Blattidae (containing the American cockroach PERIPLANETA americana), Cryptocercidae, and Polyphagidae.
The fertilizing element of plants that contains the male GAMETOPHYTES.
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
Virus diseases caused by the PICORNAVIRIDAE.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
Compounds bind to and activate ADRENERGIC BETA-2 RECEPTORS.
A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate hypersensitivity and inflammation. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and central nervous system as well as the gastrointestinal tract and the immune system.
AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives.
A beta-2 adrenergic agonist used in the treatment of ASTHMA and BRONCHIAL SPASM.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
The airflow rate measured during the first liter expired after the first 200 ml have been exhausted during a FORCED VITAL CAPACITY determination. Common abbreviations are MEFR, FEF 200-1200, and FEF 0.2-1.2.
Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.
A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).
Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
A pulmonary ventilation rate faster than is metabolically necessary for the exchange of gases. It is the result of an increased frequency of breathing, an increased tidal volume, or a combination of both. It causes an excess intake of oxygen and the blowing off of carbon dioxide.
A nucleoside consisting of the base guanine and the sugar deoxyribose.
A genus of PICORNAVIRIDAE inhabiting primarily the respiratory tract of mammalian hosts. It includes over 100 human serotypes associated with the COMMON COLD.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.
Cytosine nucleotides which contain deoxyribose as the sugar moiety.
A CC-type chemokine with specificity for CCR3 RECEPTORS. It is a chemoattractant for EOSINOPHILS.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Fluid obtained by THERAPEUTIC IRRIGATION or washout of the nasal cavity and NASAL MUCOSA. The resulting fluid is used in cytologic and immunologic assays of the nasal mucosa such as with the NASAL PROVOCATION TEST in the diagnosis of nasal hypersensitivity.
Immunosuppression by the administration of increasing doses of antigen. Though the exact mechanism is not clear, the therapy results in an increase in serum levels of allergen-specific IMMUNOGLOBULIN G, suppression of specific IgE, and an increase in suppressor T-cell activity.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. They are widespread, with clinically important roles in SKELETAL MUSCLE; LIVER; and vascular, bronchial, gastrointestinal, and genitourinary SMOOTH MUSCLE.
A condition characterized by infiltration of the lung with EOSINOPHILS due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents.
Derivatives of ACETIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxymethane structure.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Group of chemokines with adjacent cysteines that are chemoattractants for lymphocytes, monocytes, eosinophils, basophils but not neutrophils.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
The dissociation of molecules in the air into positive and negative ions under the influence of an electric field.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
The act of BREATHING in.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Asthma attacks caused, triggered, or exacerbated by OCCUPATIONAL EXPOSURE.
A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Acidic water usually pH 2.5 to 4.5, which poisons the ecosystem and adversely affects plants, fishes, and mammals. It is caused by industrial pollutants, mainly sulfur oxides and nitrogen oxides, emitted into the atmosphere and returning to earth in the form of acidic rain water.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes their proliferation and differentiation. It also acts on T-lymphocytes, MAST CELLS, and several other hematopoietic lineage cells.
Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.
The contamination of indoor air.
The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990)
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
The volume of air remaining in the LUNGS at the end of a maximal expiration. Common abbreviation is RV.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)
Adenine nucleotides which contain deoxyribose as the sugar moiety.
The maximum volume of air that can be inspired after reaching the end of a normal, quiet expiration. It is the sum of the TIDAL VOLUME and the INSPIRATORY RESERVE VOLUME. Common abbreviation is IC.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Difficult or labored breathing.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.
The major metabolite in neutrophil polymorphonuclear leukocytes. It stimulates polymorphonuclear cell function (degranulation, formation of oxygen-centered free radicals, arachidonic acid release, and metabolism). (From Dictionary of Prostaglandins and Related Compounds, 1990)
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
Compounds that accept electrons in an oxidation-reduction reaction. The reaction is induced by or accelerated by exposure to electromagnetic radiation in the spectrum of visible or ultraviolet light.
The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Helium. A noble gas with the atomic symbol He, atomic number 2, and atomic weight 4.003. It is a colorless, odorless, tasteless gas that is not combustible and does not support combustion. It was first detected in the sun and is now obtained from natural gas. Medically it is used as a diluent for other gases, being especially useful with oxygen in the treatment of certain cases of respiratory obstruction, and as a vehicle for general anesthetics. (Dorland, 27th ed)
Skin tests in which the sensitizer is injected.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.

A comparative study of the effects of ketotifen, disodium cromoglycate, and beclomethasone dipropionate on bronchial mucosa and asthma symptoms in patients with atopic asthma. (1/1287)

Asthma is a chronic inflammatory disorder of the airways that is characterized by infiltration of many inflammatory cells into the bronchial mucosa. We compared the effects of ketotifen, disodium cromoglycate (DSCG), and beclomethasone dipropionate (BDP) on inflammatory cells in the bronchial mucosa and on the asthma symptoms of patients with atopic asthma. In this 12-week parallel study, 32 patients were randomly allocated to either the ketotifen group (2 mg day-1, n = 13), DSCG group (8 mg day-1, n = 9) or BDP (400 micrograms day-1, n = 10). Each subject recorded daily asthma symptoms and peak expiratory flow (PEF). Before and after treatment, pulmonary function and bronchial responsiveness to methacholine were evaluated, and fibreoptic bronchoscopy and biopsy were performed before and after treatment. Biopsy specimens were obtained by bronchoscopy. We performed immunohistochemistry using specific monoclonal antibodies for activated eosinophils (EG2), mast cells (AA1), and T cells (CD3, CD4, and CD8). Our clinical findings showed significant improvement in symptom score and bronchial responsiveness (P < 0.01) each) in all groups. Both the DSCG and the BDP groups had significantly better symptom scores than the ketotifen group (P < 0.05, both groups). PEF significantly increased in the DSCG group in comparison to the ketotifen (P < 0.01) and BDP (P < 0.05) groups, FEV1% increased significantly in the DSCG (P < 0.01) and BDP (P < 0.05) groups in comparison to the ketotifen group. Compared with their baseline values, treatment significantly decreased EG2+ activated eosinophils, and CD3+ and CD4+ T cells, in each group (P < 0.01). Both the DSCG (P < 0.05) and the BDP groups (P < 0.01) exhibited significant decreases in AA1+ mast cell count, but this was not observed in the ketotifen group. Comparing before- and after-treatment values, only the DSCG group exhibited a significant decrease in the number of CD8+ T cells (P < 0.01). Ketotifen, DSCG, and BDP all showed anti-inflammatory activity as determined by examination of the bronchial mucosa of asthmatic patients; and both the DSCG and BDP groups had better clinical responses than the ketotifen group.  (+info)

Incorporating quality of life data into managed care formulary decisions: a case study with salmeterol. (2/1287)

Pharmacy and Therapeutics committees of managed care organizations have traditionally developed formularies by limiting the numbers and kinds of pharmaceuticals they purchase, with the goal of cutting costs. These attempts to manage pharmaceutical costs do not take into account the interrelationship of the costs of various components of care; thus, drug costs may decrease, but expenditures for utilization of other resources may increase. Cost-minimization and basic cost-effectiveness studies, on which many prior- authorization and formulary programs are based, only evaluate only the cost of the drug and its effectiveness. However, with the heightened competition in the healthcare market, emphasis is increasingly being laid on patient satisfaction and outcomes. Cost-utility analysis is a potentially superior pharmacoeconomic tool because it evaluate the effect of drug therapy on quality of life; however, data from such analyses are seldom readily available to the committees that evaluate a drug's potential effects on the entire healthcare system. The purpose of this review is to stress the importance of approaching formulary management from a wider perspective and to emphasize that the results of cost-utility studies should be proactively evaluated and incorporated into decisions regarding formularies. This is especially important for symptom-intensive diseases, such as asthma, in which the quality of life can be notably impaired. Cost-utility analyses should be conducted for all newer therapies, such as salmeterol, which are highly effective and which have a positive impact on quality of life, to determine the overall effect on the managed care plan's budget.  (+info)

Long-term management of asthma: how to improve outcomes. (3/1287)

Improved clinical outcomes in asthma patients have been demonstrated in several clinical trials that applied the National Institutes of Health (NIH) guidelines for the long-term management of asthma. Environmental control, objective monitoring, drug therapy, and partnership in patient education are the major components of optimal management. Inhaled antiinflammatory agents are of major importance for long-term control in patients with persistent asthma. Adequate patient education is absolutely essential for excellent, cost-effective care of patients with asthma. Improved outcomes in adults with asthma have been demonstrated at clinics initiated and managed by pharmacists. Further trials are needed with large numbers of patients in managed care organizations.  (+info)

Effects of an asthma management program on the asthmatic member: patient-centered results of a 2-year study in a managed care organization. (4/1287)

OBJECTIVE: To report the results of a 2-year pilot program of asthma education based on National Heart, Lung, and Blood Institute treatment guidelines. PATIENTS AND METHODS: Asthmatic members (n = 6698) of a managed care organization received education about their condition directly or through their primary care physician. Medical and pharmacy administrative claims data were reviewed to measure acute asthma events and prescribed therapies in the first (the baseline) and second years of the study. The claims data were augmented by member surveys from a stratified random sample of 2734 asthmatic patients who were members (6 years of age or older) in the baseline year. RESULTS: Compared with the first year, asthmatic members received fewer inpatient services and the proportion of asthmatic members prescribed oral inhaled corticosteroids increased 30% in the second year. Health-related quality of life, measured with validated general and disease-specific instruments; satisfaction with the quality of care; exposure to patient education; knowledge of the disease; and member's confidence in their ability to manage their disease showed statistically significant improvements during the follow-up year of the program for both adult and child asthmatic members. CONCLUSION: For asthmatic members of this health plan, a comprehensive asthma health management program improved processes of care and outcomes.  (+info)

Hyperbaric oxygen increases plasma exudation in rat trachea: involvement of nitric oxide. (5/1287)

This study investigates the microvascular permeability changes in tracheal tissue of rats exposed to hyperbaric oxygen (HBO). Rats, following exposure to HBO or ambient air (control animals) for 1.5, 3 and 6 h, were prepared for recording of nitric oxide exhaled (FENO) in air using a chemiluminescence analyser. The level of FENO was not statistically different in the two groups. Plasma exudation, evaluated by measuring the leakage of Evans blue (EB) dye into the tracheal tissue, was significantly elevated (48, 86 and 105% at 1.5, 3 and 6 h, respectively) in HBO-treated rats. Plasma exudation in the trachea of control rats was significantly increased (42%, P<0.05) by NG-nitro-L-arginine methyl ester (L-NAME), whereas it was significantly reduced (31%, P<0.05) in rats exposed to HBO for 3 h. N-acetylcysteine (NAC) and flunisolide significantly prevented the increase in plasma leakage in HBO-treated rats. In contrast, indomethacin was devoid of anti-exudative activity in these experiments. Western immunoblot showed a significant increase in the level of inducible nitric oxide synthase (iNOS) protein in the tracheal homogenates of HBO-treated rats, as compared to basal levels. These results indicate that nitric oxide (NO) is involved in the maintenance of microvascular permeability in tracheal tissue of rats. The protective effect observed with the steroid seems to support this hypothesis. Furthermore, the beneficial action of NAC underlines that reactive oxygen species participate in the microvascular permeability changes observed in tracheal tissue of rats exposed to HBO.  (+info)

Persistent cough: is it asthma? (6/1287)

The aim of this study was to determine if children in the community with persistent cough can be considered to have asthma. A validated questionnaire was given to the parents of 1245 randomly selected children aged 6-12 years. Atopy was measured with skin prick tests. Children with persistent cough had less morbidity and less atopy compared with children with wheeze. Although the syndrome commonly referred to as "cough variant asthma" could not be shown in this study, a significant number of children with persistent cough had been diagnosed as having asthma and were treated with asthma medications including inhaled corticosteroids. Studies are urgently needed to determine the appropriate treatment for children with persistent cough.  (+info)

Effect of the leukotriene receptor antagonist pranlukast on cellular infiltration in the bronchial mucosa of patients with asthma. (7/1287)

BACKGROUND: It has been reported that pranlukast reduces the antigen induced immediate and late phase asthmatic responses, airway hyperreactivity to acetylcholine, and pulmonary eosinophil accumulation in guinea pigs. A study was undertaken to test the hypothesis that pranlukast may reduce the number of inflammatory cells in the bronchial mucosa of patients with asthma. METHODS: A double blind, placebo controlled study was performed in 17 mild to moderate asthmatic subjects to examine changes in inflammatory cell infiltration in response to pranlukast (225 mg orally twice per day for four weeks). Comparisons of the mean daily beta 2 agonist use, symptom score, FEV1 percentage predicted, and airway methacholine responsiveness were made before and after treatment. Using fibreoptic bronchoscopy, bronchial biopsy specimens were obtained before and after treatment with either pranlukast (n = 10) or placebo (n = 7). Immunohistology was performed using monoclonal antibodies for CD3, CD4, CD8, CD68, NP57, AA1, EG1, EG2, gamma GTP and CD19. RESULTS: When the pranlukast and placebo treated groups were compared there were decreases in beta 2 agonist use, symptom score, and airway methacholine responsiveness after pranlukast but no increase in FEV1 was seen. The clinical response in patients treated with pranlukast was accompanied by a reduction in CD3 (median difference -37, 95% confidence interval (CI) -69 to -1; p < 0.05), CD4 (median difference -28, 95% CI -49 to -8; p < 0.01), AA1 (median difference -15, 95% CI -26 to 0; p < 0.05) and EG2 positive cells (95% CI -35 to 0; p < 0.05), but not in EG1 positive eosinophils, gamma GTP positive cells, and CD19 positive plasma cells. CONCLUSIONS: These results support the view that pranlukast may act by inhibition of bronchial inflammation in patients with asthma.  (+info)

Systemic activity of inhaled and swallowed beclomethasone dipropionate and the effect of different inhaler devices. (8/1287)

Inhaled glucocorticoids such as beclomethasone dipropionate, which are used in the treatment of asthma, may be associated with systemic adverse effects. To determine whether any systemic absorption following the inhalation of beclomethasone was a result of drug being absorbed from the lung (inhaled fraction) or the gastrointestinal tract (swallowed fraction), we studied normal subjects after the inhalation or swallowing of 2 mg beclomethasone dipropionate. Systemic activity was assessed using early morning cortisol suppression. Both inhaled and swallowed fractions produced significant systemic activity, the degree of which depended on the inhaler device used. Systemic activity was greater using a dry powder inhaler (52%) than using a metered dose inhaler with a large volume spacer (28%). These findings suggest that to limit potential adverse effects from high-dose beclomethasone dipropionate it is better to use a metered dose aerosol with large volume spacer than a dry powder.  (+info)

New York City, NY: March, 2020 - Published via (Wired Release) - The research report on the international Preventive Asthma Drugs market is a compilation of intelligent, broad studies research so one can assist players and stakeholders to make informed business choices in future. It gives precise and reliable sugges...
BACKGROUND: Improved adherence to inhaled corticosteroids (ICS) is recognized as an important factor in reduced morbidity, mortality and consumption of health care resources. The present study was designed to replicate previous reports of patient adherence with fluticasone/salmeterol in a single inhaler (FSC), fluticasone and salmeterol in separate inhalers (FP+SAL), fluticasone and montelukast (FP+MON), fluticasone alone (FP) and montelukast alone (MON).. METHODS: A 24-month observational retrospective study was conducted using administrative claims data. Subjects were 12 years old with 24 months of continuous enrollment; had 1 asthma claim (ICD-9: 493), 1 short-acting beta(2)-agonist claim, and 1 FSC, FP, SAL, or MON claim. Outcomes included asthma medication refill rates and persistence measured by treatment days. This study was designed with a unique population of patients with asthma from different health plans to validate previous findings.. RESULTS: A total of 3,503 subjects were ...
About Us - Contact Us Google+ Advertise: 2 million page views AllergyCases.org: Case-based Curriculum of Allergy and Immunology Disclaimer: All opinions expressed here are those of their authors and not of their employer. The information provided here is for educational purposes only and is not intended to provide medical advice. By accessing the web site, the visitors acknowledge that there is no physician-patient relationship between them and the authors. Patient Information ...
This is a Phase II, multicenter, randomized, double blind, placebo controlled, multiple-dose study designed to evaluate the efficacy, safety, and tolerability of subcutaneously administered HAE1 in subjects 12-75 years old with moderate to severe asthma whose symptoms are inadequately controlled with moderate to high-dose ICS and LABA ...
The latest from http://brainblogger.com! Life expectancy has increased dramatically in the last few decades, particularly in the most developed countries. And thats a wonderful thing. But this increase has brought a number of new challenges in health and healthcare, specifically in age-related conditions, such as neurological conditions. One of the great challenges in medical research…
Corticosteroids. These medications can be given in a variety of ways. Some of them are inhaled, while others may be taken as a pill or liquid, or even as an injection. The steroids taken by mouth can have more side effects than those that are inhaled. Inhaled steroids are safe and effective controller medications and should be taken every day. Consult your childs doctor about the best choice for your child ...
The 2015 ACT Scores are out and five years after the introduction and implementation of Common Core, the scores are stagnant.
Information about Warren Wilson College ACT scores. Completion of a college degree program can qualify you to enter the workforce immediately. To get started, browse degree programs and certificate courses online.
Are you a leader? Admissions officers want to know. OK, youve taken the first step: Youve got a list of schools -- some safety, some fit, some reach -- based on your grades and your SAT or ACT scores. But now things have gotten confusing. There...
The majority pediatric asthma patients in Shanghai are mild persistent asthma. These patients require controller medications every day to achieve and maintain control. Leukotriene receptor antagonist is one of the options which have been recommended to use as a mono controller therapy. Patient satisfaction and compliance was better with montelukast, attributed to oral intake and convenience. Owing to its easy and simple oral once a day administration montelukast was found to be advantageous over ICS. On the other hand, recent studies have shown that there is a considerable degree of airway remodeling in peripheral airways in patients with mild asthma.The new information points out the need for large, long term studies on the treatment of mild persistent asthma, with an emphasis on exacerbations, remodeling, and the relationship between these outcomes and markers of asthma control. TGF-β participates in the initiation and propagation of inflammatory and immune responses in the airways. The ...
BackgroundMany patients and healthcare professionals believe that work-related psychosocial stress, such as job strain, can make asthma worse, but this is not corroborated by empirical evidence. We investigated the associations between job strain and the incidence of severe asthma exacerbations in working-age European men and women. MethodsWe analysed individual-level data, collected between 1985 and 2010, from 102 175 working-age men and women in 11 prospective European studies. Job strain (a combination of high demands and low control at work) was self-reported at baseline. Incident severe asthma exacerbations were ascertained from national hospitalization and death registries. Associations between job strain and asthma exacerbations were modelled using Cox regression and the study-specific findings combined using random-effects meta-analyses. ResultsDuring a median follow-up of 10years, 1 109 individuals experienced a severe asthma exacerbation (430 with asthma as the primary diagnostic ...
If you want to manage asthma symptoms, you have to use anti-inflammatory medications which work on long-term. Anti-inflammatory asthma drug works by interfering with the activity and chemistry of immune cells such as mast cells which cause inflammation in the airway walls. Anti-inflammatory asthma drug also helps rest the airway muscles that narrow and constrict during broncho-spasms.. Anti-inflammatory asthma drugs prevent and reduce swelling, inflammation and mucus in the airways. They also stop the symptoms such as wheeze, cough and breathlessness. They should be taken on regular basis and are slow acting.. There are two types of anti-inflammatory asthma drugs: steroidal and non-steroidal. The most common steroids include beclomethasone, flunisolide, fluticasone and budesonide. The non-steroids include sodium cromoglycate and nedocromil.. Corticosteroid inhalers:. Corticosteroid asthma drugs are the most effective preventers. This asthma drug works by reducing and preventing airway ...
TY - JOUR. T1 - The Role of the Six-minute Walk Test, Pulmonary Function Test, and Asthma Control Test in Asthmatic Patients-a Preliminary Report. AU - Chen, Shiau-Yee. AU - Hsu, Han Lin. AU - Lin, Jiu Jenq. AU - 余, 明治(Ming-Chi Yu). AU - 江, 玲玲(Ling-Ling Chiang). AU - 李, 俊年(Chun-Nie Lee). PY - 2010. Y1 - 2010. N2 - Purpose: Asthma control is the main concern for related professionals when approaching asthmatic patients. In this study, we selected three different tools to understand asthma control status in patients with asthma.Methods: Twenty-six patients with asthma were recruited in the study. These patients underwent pulmonary function testing with spirometry and the six-minute walk test, and completed an asthma control questionnaire (Asthma Control Test, ACT). In statistical analysis, the Spearman rank correlation and Pearson correlation coefficient were used for correlation between measured variables. For explanation, potential prediction variables were entered into a ...
The University of Sydney in Australia is currently performing asthma research and is trying to stop the destructive cells responsible for the inflammatory response from being produced. These cells are stimulated by chemical messengers called cytokines and current medications, for example steroids which help to reduce the concentration of cytokines and stop the inflammatory response.. Steroids also have an effect on a number of other tissues in the body and are known to produce side effects. Asthma research at the university is undergoing on how the cytokines are produced and how they can stop production and also inflammatory response.. Woolcock Institute of Medical Research is conducting an asthma research on the long-term effects of asthmatic episodes on the lining of the airways and how the inflammatory response can affect and how current medications work.. They are trying to develop a non-invasive method that will allow them to determine the degree of scarring and how this affects the ...
asthma medications - MedHelps asthma medications Center for Information, Symptoms, Resources, Treatments and Tools for asthma medications. Find asthma medications information, treatments for asthma medications and asthma medications symptoms.
TY - JOUR. T1 - Management of asthma exacerbations. AU - Chestnutt, Mark. PY - 2002/1/1. Y1 - 2002/1/1. N2 - The 1997 Expert Panel Report 2 from the National Asthma Education and Prevention Program* details principles and goals for managing asthma exacerbations, based on scientific literature and the opinion of the panel. The panels recommendations are summarized here, along with approaches to the evaluation and management of patients with asthma exacerbations. Methods to assess and classify the severity of asthma exacerbations are discussed, and treatment objectives for mild, moderate, and severe exacerbations are presented, along with a discussion of postinfectious acute airway hyperresponsiveness. A review of pharmacologic agents used in the treatment of asthma exacerbations is also included. Key points in the management of asthma exacerbations include the notion that early treatment is the best strategy for management. Important elements of early treatment include recognition of early signs ...
AIMS: This retrospective, observational cohort study aimed to compare treatment outcomes and healthcare costs in the year after initiation of maintenance treatment with budesonide/formoterol or salmeterol/fluticasone in a German healthcare setting. METHODS: Data on German asthma patients initiating treatment with budesonide/formoterol or salmeterol/fluticasone between June 2001 and June 2005 were obtained from the IMS Disease Analyzer database. The primary outcome was the probability of treatment success, defined according to short-acting beta(2)-agonist prescriptions and switches or addition of controller medications, during the postindex year. A secondary definition of treatment success included hospitalisations and oral corticosteroid (OCS) prescriptions. Secondary outcomes included severe asthma exacerbations, defined as >or=1 OCS prescription, asthma-related hospitalisation and/or referral. The effect of treatment on costs was estimated using generalised linear models, adjusting for patient ...
As co-Editors in Chief (and Professor Canonica as President of Interasma), it is our pleasure to welcome our colleagues to this first issue of the journal Asthma Research and Practice (ARP) [1]. This will be an open-access online journal, and thus easily accessible to a large audience. The aims and scope of ARP will be to publish original research articles and state of the art reviews focusing on risk factors, diagnosis and management of asthma at all ages. Since asthma is a disease that comprises diverse endotypes and is often accompanied by co-morbidities, we expect and welcome manuscripts on topics such as obese asthma, exercise-induced asthma, asthma-COPD overlap syndrome, occupational asthma, and others [2, 3]. Although existing journals in fields as diverse as paediatrics, internal medicine, allergy and pulmonology include articles on asthma, we believe that a journal entirely dedicated to asthma is both valuable and necessary. Moreover, we are committed to have a section devoted ...
As a long-term advocate for children with asthma and their families, Visionary Consulting Partners, LLC (Visionary) anticipates the release of new national guidelines for the diagnosis, treatment, and management of asthma in August of 2019. The most recent iteration of guidelines was published in 2007 by the National Asthma Education and Prevention Program (NAEPP) Committee, coordinated by the National Heart, Lung, and Blood Institute (NHLBI). The 2007 National Asthma Education and Prevention Program Guidelines for the Diagnosis and Management of Asthma provided an evidence-based foundation for physicians, respiratory therapists, pharmacists, researchers, and educators to diagnose, treat, and manage asthma in patients. In 2014, an Asthma Expert Working Group was convened by the NHLBI with the goal of determining the need and scope of an update to these guidelines. Currently, the group is working to identify critical findings across systematic reviews, meta-analyses, and clinical trials to inform ...
Asthma is one of the most common diseases amongst children. Blood eosinophil count and neutrophil-lymphocyte ratio (NLR) are known as markers for phenotyping asthma. This study was performed to investigate blood eosinophil count and NLR as predictors of hospitalization in pediatric asthma exacerbations. In this cross-sectional study, children admitted to hospital ward for more severe asthma exacerbation were compared with non-hospitalized children with moderate to severe asthma exacerbation whose asthma exacerbation was managed in emergency department or outpatient clinic. We investigated patients characteristic and factors associated with hospitalization. A total of 211 children with moderate to severe asthma exacerbation (mean age $$5.76 \pm 3.28$$ years old) were enrolled in the study including 91 hospitalized patients and 120 non-hospitalized patients. For the prediction of
The Asthma USA survey showed that uncontrolled asthma had significant medical consequences. Adults with uncontrolled asthma were more prone to need treatment with oral corticosteroids, visit the emergency room, or be hospitalized, compared with patients with well-controlled asthma.. Children with uncontrolled asthma also were in the same situation. Earlier studies have shown that uncontrolled asthma can put patients at risk for increased asthma symptoms, sudden asthma attacks, hospitalization, and even death.. The survey included >81,500 households that were assessed using the Asthma Control Test (ACT). Of the >10,000 adults with self-reported asthma taking the ACT, 41% had a score of 19 or less, which indicates uncontrolled asthma. The survey also examined scores from the Childhood Asthma Control Test and ACT in >3000 children respondents between the ages of 4 and 17. The results indicated that 31% of the children with asthma between the ages of 4 and 11 and 25% of those between the ages of 12 ...
BACKGROUND: Asthma is a common chronic disease affecting patients health status and quality of life. Although recent guidelines focus on asthma control, asthma remains poorly controlled in many patients even under specialist care. Asthma Control Test™ (ACT) is a short, simple, patient-based tool that provides consistent assessment of asthma.OBJECTIVE: The aim of this study was to estimate the relationship of ACT with objective measures of lung function and inflammation such as forced expiratory volume in 1st second (FEV(1)) and exhaled nitric oxide (FeNO) in outpatients admitted for initial diagnosis of asthma and at follow-up.METHODS: One hundred and sixty (104 women and 56 men, mean age 39.7 ± 16.6 years) asthmatic patients with newly diagnosed asthma were included in the study. Patients completed the ACT questionnaire and underwent a detailed clinical examination, FeNO measurement, and prebronchodilator spirometry before (visit 1) and 4-12 weeks after initiation of treatment (visit ...
About Severe Asthma. Asthma affects 315 million individuals worldwide, and up to 10% of asthma patients have severe asthma, which may be uncontrolled despite high doses of standard-of-care asthma controller medicines and can require the use of chronic oral corticosteroids (OCS).. Severe, uncontrolled asthma is debilitating and potentially fatal with patients experiencing frequent exacerbations and significant limitations on lung function and quality of life. Severe, uncontrolled asthma has an eight times higher risk of mortality than severe asthma.. Severe, uncontrolled asthma can lead to a dependence on OCS, with systemic steroid exposure potentially leading to serious short- and long-term adverse effects, including weight gain, diabetes, osteoporosis, glaucoma, anxiety, depression, cardiovascular disease and immunosuppression. There is also a significant physical and socio-economic burden of severe, uncontrolled asthma with these patients accounting for 50% of asthma-related costs.. About the ...
A stranger would never guess my friend Catrina has asthma. She plays three varsity sports, sings along to entire musicals without losing her breath, and overall leads an active, nonstop life. Because of the incredible advancements in asthma treatment, Catrina seems practically indistinguishable from someone without asthma. Even I have never seen her reach for her inhaler. It is only because of our close friendship that I know she takes medicine to control her asthma and frequently visits an allergist. How has asthma treatment come so far? The use of animals in asthma research has lead to many groundbreaking discoveries that have benefited asthma sufferers like Catrina. Early asthma studies relied on animal research, and so does the current research that develops the kind of new medicines that Catrina uses today.. Asthma is defined by the National Institutes of Health as a chronic lung disease that inflames and narrows the airways, with symptoms of recurring periods of wheezing, tightness, ...
Despite the regular treatment with inhaled corticosteroids (ICS) or ICS plus long-acting beta2-agonists, permits to control de majority of asthmatics, a significant proportion of patients does not respond to this treatment. This review was aimed to explore the role of psychological factors associated to the unsuccessful fulfilment of optimal levels of asthma control, especially in patients suffering from severe asthma. The results of a Medline search were 5510 articles addressed to different psychological key concepts, constructs and variables. This review will highlight how some selected psychological factors may have a burden on asthma management. Evidences are now available about the link between asthma (in terms of severity and control), some psychological aspects (subjective perception, alexithymia, coping style) and mental health (anxiety, depression). Taking into account this most probably bidirectional influence, a screening of mental symptoms and psychological aspects related to asthma, could
Based on the modified GINA criteria, of the 397 children in the sample, 143 (36%) had intermittent asthma; 160 (40%) had mild persistent asthma; 51 (12.8%) had moderate persistent asthma; and 43 (10.8%) had severe persistent asthma. In 60 children, occasional limitation of daily activities was the indicator of greatest severity. Taking into account that responses to the remaining questions were not related to more severe asthma, a decision for more conservative categorization was made, and these children were classified as having mild persistent asthma. Based on the ISAAC questionnaire, 90 of the 397 children (22.3%) provided positive responses to questions assessing symptom severity, whereas 307 (77.3%) replied in the negative.. Comparison of both asthma severity criteria according to data from the second survey (Table 2) shows that, the greater the severity of the disease according to GINA criteria, the greater the proportion of children with more severe symptoms as assessed by ISAAC. No ...
Injections may be a helpful add-on treatment for certain people with severe allergic asthma. Learn more about how it works, how much it costs, and some of the potential side effects.
Asthma is a chronic disease of the air passages of the lungs which inflames and narrows them, causing continuous attacks of breathlessness, bronchospasm and reversible airflow obstruction. Asthma is considered to be one of the most common disease to affect the population worldwide, it is also a life threatening dise...
About Severe Asthma. Asthma affects 315 million individuals worldwide, and up to 10% of asthma patients have severe asthma which may be uncontrolled despite high doses of standard-of-care asthma controller medicines and can require the use of chronic OCS.. Severe, uncontrolled asthma is debilitating and potentially fatal with patients experiencing frequent exacerbations and significant limitations on lung function and quality of life. Severe, uncontrolled asthma has higher risk of mortality than severe asthma.. Severe, uncontrolled asthma can lead to a dependence on OCS, with systemic steroid exposure potentially leading to serious short- and long-term adverse effects, including weight gain, diabetes, osteoporosis, glaucoma, anxiety, depression, cardiovascular disease and immunosuppression. There is also a significant physical and socio-economic burden of severe, uncontrolled asthma with these patients accounting for 50% of asthma-related costs.. About Fasenra (benralizumab). Fasenra is a ...
TY - JOUR. T1 - Quantifying asthma symptoms in adults. T2 - The Lara Asthma Symptom Scale. AU - Wood, Pamela Runge. AU - Smith, Brad. AU - ODonnell, Louise. AU - Galbreath, Autumn Dawn. AU - Lara, Marielena. AU - Forkner, Emma. AU - Peters, Jay I.. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Background: Accurate assessment of asthma symptoms is critical in research and clinical settings. A multidimensional asthma control questionnaire could provide more accurate information about asthma symptoms than global assessments, which often overestimate asthma control. Objective: We sought to evaluate the efficacy of the Lara Asthma Symptom Scale (LASS) in adults with persistent asthma. Methods: Participants were 18 to 64 years of age with persistent asthma. Data were collected at baseline, 6 months, and 12 months. We described the construct and predictive validity of the LASS by comparing it with measures of pulmonary function (FEV1), asthma-specific quality of life (Junipers Asthma Quality of Life ...
TY - JOUR. T1 - Measures of asthma control. AU - Bime, Christian. AU - Nguyen, Jessica. AU - Wise, Robert A.. PY - 2012/1/1. Y1 - 2012/1/1. N2 - Purpose of Review: Over the past decade, the concept of asthma control as distinct from asthma severity has been clearly defined. Well controlled asthma is the goal of therapy in all asthma patients. This review is a comprehensive description of the tools currently available for a methodical assessment of different aspects of asthma control in clinical practice and research. Recent Findings: Several questionnaires for assessing asthma control have been extensively validated in adults. In children, validation data are less extensive. Considerable overlap exists between asthma control measures and measures of asthma-specific quality of life. Asthma-specific quality-of-life questionnaires have been used as primary outcome measures in major clinical trials evaluating asthma therapy. Biomarkers that reflect eosinophilic inflammation of the airways are used ...
By Jaclyn Chasse N.D.. Over 22 million Americans have asthma and it is one of the most common pediatric chronic diseases, affecting about 6 million children. Asthma is a condition characterized by cough, difficulty breathing, wheezing and chest tightness. Asthma has several underlying pathological mechanisms including bronchoconstriction, bronchial hyperreactivity, and underlying inflammation and airway edema.. The National Asthma Education and Prevention Program (NAEPP) first published guidelines for care in 1991 and published the most recent update in 2007. One of the key clinical activities recommended by the NAEPP is the development of a written asthma action plan in partnership with the patient. An asthma action plan is a written tool which outlines appropriate care for an asthma patient. The stoplight tool is on example of a written asthma action plan that categorizes severity of asthma into a red, yellow, or green zone. Each zone corresponds with a different stage of asthma and outlines ...
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The trial was a cross-sectional cohort study of patients enrolled in the Pediatric Asthma Care Patient Outcomes Research Team II (PAC-PORT), a multicenter randomized trial of asthma care improvement strategies. PAC-PORT included 42 different practices in three geographic locations. Participants were identified through searches for pharmacy claims for asthma medication use and claims that identified hospitalizations, emergency department visits, and ambulance encounters in children three to 15 years of age who were diagnosed with asthma.. Children who met the criteria for mild or moderate persistent asthma were included in the study. The main outcome measures were asthma symptom days, use of reliever and controller medications, and adequacy of control as determined by face-to-face interviews. The term asthma symptom dayswas defined as the number of days in the preceding two weeks on which the child had cough, wheezing, or limitation in activity.. Of the 638 children who qualified for the study, ...
Asthma is a chronic inflammatory disease from the airway that comprises a number of etiologies and inflammatory phenotypes. antibody towards the alpha subunit from the interleukin-4 receptor, in individuals with consistent, moderate-to-severe asthma and raised eosinophil levels. Strategies We enrolled sufferers with consistent, moderate-to-severe asthma and a bloodstream eosinophil count number of at least 300 cells per microliter or a sputum eosinophil degree of at least 3% who utilized medium-dose to high-dose inhaled glucocorticoids plus long-acting beta-agonists (LABAs). We implemented dupilumab (300 mg) or placebo subcutaneously once every week. Sufferers had been instructed to discontinue LABAs at week 4 also to taper and discontinue inhaled glucocorticoids during weeks 6 through 9. Sufferers received the analysis medication for 12 weeks or until a protocol-defined asthma exacerbation happened. The principal end stage was the incident of the asthma exacerbation; supplementary end factors ...
This.2 GINA has the Asthma Control Test is recommended. Overall, it is the implementation of effective, GINA guideline-defined treatment strategy for asthma
Jason Lang, MD, MPH. Summary. BACKGROUND: Poorly controlled asthma especially in children remains a major public health problem. Many children with poor asthma control experience gastroesophageal reflux (GERD). The effect of mild GERD on asthma remains controversial despite studies involving proton-pump inhibitors (PPIs) assessing their effect on asthma.. GAP: Past inconsistent findings regarding the effect of PPIs on asthma control may have resulted from ineffective dosing strategies of proton-pump inhibitors employed in these studies. Drug levels and efficacy vary widely in the population and depend on genetics. Dosing in children which adjusts for the gene CYP2C19 may improve efficacy and reduce side-effects leading to improved asthma control.. HYPOTHESES:. #1: Our group hypothesizes that genotype-tailored lansoprazole dosing will reduce asthma symptoms in children with mild symptoms of GERD compared to placebo.. #2: CYP2C19 and ABCB1 genetic variants influence the pharmacokinetics (drug ...
Human translational asthma research is supported by the Parkes Family foundation, as well as individual Division investigators. The Parkes family founded the Mary Parkes Asthma Center, which became affiliated with the Pulmonary Division in 1995. We started a Severe Asthma Clinic in 2007 with the goal of providing expert evidenced-based care using non-invasive biomarkers to guide therapy and accelerate research. The Severe Asthma Clinic is staffed by Drs. Michael Larj, Sandhya Khurana, and the Mary Parkes Asthma Research Fellow.. A major theme of basic asthma research is to define the cellular and molecular mechanisms for dysregulated immune responses in asthma. Specific areas of interest include: (i) activation of lung dendritic cells by ambient air pollution and allergen particles, (ii) the role of transcription factors in T cell activation and allergic immune responses, and (iii) molecular mechanisms regulating oxidative stress. Laboratory-based investigators include Dr. Steve Georas, Dr. Jia ...
The overall goal of the Severe Asthma Research Program (SARP) is to develop a new paradigm for the understanding of severe asthma and its sub-phenotypes, in chi...
At-risk patients to target for special review. · Children with frequent consultations for respiratory infections. · Children over 5 years old with persistent asthma symptoms. · Asthma patients with psychiatric disease or learning disabilities. · Patients using large quantities of ?-2 agonists. Monitor asthma control through regular checks on the proportion of patients with asthma:. lwho have no or few current symptoms. lwho are able to use their prescribed inhalers effectively. lwho use inhaled steroids. lwith normal lung function (PEF greater than 80 per cent). lwith actual/best PEF greater than 85 per cent. lwith an asthma action plan. Organisation of care. Practices should use a structured record including inhaler technique, morbidity, PEF, current treatment and action plans Source: Thorax (February) ...
The study objective is to investigate the safety and effectiveness of Spiriva Respimat in patients with mild to moderate persistent asthma under real-world use
SATURDAY, Oct. 12, 2019 (HealthDay News) -- Fall can be a challenging time of the year for kids with asthma, an expert says.. Although asthma can flare up for a number of reasons, a lot of people with allergies also have asthma, and asthma can be triggered by allergies. So the fall is a tough time for asthmatic sufferers, said Dr. Gaurav Kumar, a pediatrician at LifeBridge Health in Baltimore.. While many kids do well with their asthma during the summer, problems often accompany the return to school. You go from taking these outdoor summer vacations to now being in a classroom again, Kumar explained. So now youre in contact with people in closed spaces. And of course, what happens is germs are more likely to spread that way. So you could get colds from friends who have colds, and then that becomes a trigger for asthma. Parents need to make sure their childs asthma is under control. If a child stopped taking preventive asthma medications regularly during the summer, they should resume ...
SATURDAY, Oct. 12, 2019 (HealthDay News) -- Fall can be a challenging time of the year for kids with asthma, an expert says.. Although asthma can flare up for a number of reasons, a lot of people with allergies also have asthma, and asthma can be triggered by allergies. So the fall is a tough time for asthmatic sufferers, said Dr. Gaurav Kumar, a pediatrician at LifeBridge Health in Baltimore.. While many kids do well with their asthma during the summer, problems often accompany the return to school. You go from taking these outdoor summer vacations to now being in a classroom again, Kumar explained. So now youre in contact with people in closed spaces. And of course, what happens is germs are more likely to spread that way. So you could get colds from friends who have colds, and then that becomes a trigger for asthma. Parents need to make sure their childs asthma is under control. If a child stopped taking preventive asthma medications regularly during the summer, they should resume ...
SATURDAY, Oct. 12, 2019 (HealthDay News) -- Fall can be a challenging time of the year for kids with asthma, an expert says.. Although asthma can flare up for a number of reasons, a lot of people with allergies also have asthma, and asthma can be triggered by allergies. So the fall is a tough time for asthmatic sufferers, said Dr. Gaurav Kumar, a pediatrician at LifeBridge Health in Baltimore.. While many kids do well with their asthma during the summer, problems often accompany the return to school. You go from taking these outdoor summer vacations to now being in a classroom again, Kumar explained. So now youre in contact with people in closed spaces. And of course, what happens is germs are more likely to spread that way. So you could get colds from friends who have colds, and then that becomes a trigger for asthma. Parents need to make sure their childs asthma is under control. If a child stopped taking preventive asthma medications regularly during the summer, they should resume ...
The two trials, published in the journal The Lancet, looked at the safety and efficacy of benralizumab as an add-on therapy for patients with severe, uncontrolled asthma - a group of patients who have few treatment options available and high rates of hospitalisation.. Additional therapeutic options to control severe asthma are urgently needed and our findings support the use of benralizumab as an add-on therapy for the treatment of severe asthma with persistent eosinophilia, said one of the researchers J. Mark FitzGerald from University of British Columbia, Vancouver, Canada.. Eosinophils are a type of white blood cell and part of the immune system controlling the mechanism associated with allergy and asthma.. Many patients with severe, uncontrolled asthma have high levels of eosinophils in the blood and airways (known as eosinophilia) which is associated with frequent asthma exacerbations, high symptom burden and impaired lung function.. Cytokine interleukin-5 (IL-5) is the main driver of ...
Background - Asthma is an inflammatory condition often punctuated by episodic symptomatic worsening, and accordingly, patients with asthma might have waxing and waning adherence to controller therapy.Objective - We sought to measure changes in inhaled corticosteroid (ICS) adherence over time and to estimate the effect of this changing pattern of use on asthma exacerbations.Methods - ICS adherence was estimated from electronic prescription and fill information for 298 participants in the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity.
If you are an individual or represent an organization that prefers to receive by email the registration form that you can download or print out, or for more information, please contact [email protected] or Ashley Kissinger, AE-C, at 510.620.3644. CDPH is registering for sessions in Californias Central Valley and will consider registrations for other California areas if resources allow. Please share these promotional flyers. ...
The Particulars: Research shows that chronic asthma and cardiovascular disease (CVD) share a common inflammatory pathophysiology. However, few studies have explored the potential association between persistent asthma-defined as requiring daily controller medications-and an increased risk of CVD.. Data Breakdown: Researchers compared the rates of CVD over 9 years among patients with persistent asthma, intermittent asthma, or no asthma for a study. Among those with persistent asthma, 84.1% were alive and free from CVD, compared with a 91.1% rate for those with intermittent asthma and a 90.2% rate for those without asthma. Patients with persistent asthma had about a 60.0% higher risk of CVD events that those without asthma.. Take Home Pearl: There appears to be a strong association between persistent asthma and risk for CVD. ...
Background: Asthma is the chronic inflammation of airways characterized by eosinophilic infiltration, mucus overproduction, airway hyper-responsiveness and airway remodeling. These changes are induced mostly by cytokines which are produced by T helper (Th) 2 cells. Recently, the role of interleukin-23 (IL-23) in the pathogenesis of adultallergic asthma has been studied. Objective: To explore IL-23 serum levels and its expression in persistent asthma compared with healthy children younger than five years old. Method: Blood samples of 40 children with mild and severe persistent asthma were compared to 34 healthy children regarding IL-23 serum levels and gene expression using enzyme-linked immunosorbentassay (ELISA) and real time quantitative polymerase chain reaction (PCR). Results: The IL-23 gene expression level was significantly different in the 25 children with mild persistent asthma and the 15 children with severe persistent asthma compared to the control group (p=0.001).There was no significant
Poor asthma control, as measured by the ACT, C-ACT or ACQ, is associated with reduced lung function, increased risk of exacerbations and elevated exhaled nitric oxide fraction, and is lower in children not regularly using inhaled corticosteroid maintenance therapy [17, 18, 23-27]. Children with asthma and allergic rhinitis have poorer asthma control and a higher risk of exacerbations than those without allergic rhinitis [28, 29]. Children whose parents are concerned about the usefulness and side-effects of inhaled corticosteroid therapy also have poorer asthma control [30], and this association is caused by poor adherence to inhaled corticosteroids [31]. Follow-up studies have shown that changes in composite measures of asthma control reflect changes in the overall clinical assessment of asthma control by physicians, and the need to step up therapy [32]. No studies have assessed whether repeated structured assessment of asthma control by composite control measures helps to improve asthma control ...
1 Reported any of the following during the past year: asthma medication use, asthma symptoms, or MD visits for asthma. 2 Reported none of the following during the past year: asthma medication use, asthma symptoms, or MD visits for asthma. 3 Aged ≥ 18 years. ± Sample size excludes DK/Refused. § Standard error. † Confidence interval. N/A: Estimate not available (N/A) if the unweighted sample size for the denominator was , 50 or if the relative standard error was , 0.30 ...
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Asthma Action Plan. You and your doctor write an Asthma Action Plan together. It is a written plan that will help you stay away from triggers and take medicine to control your asthma symptoms. Learn more about an Asthma Action Plan. Always keep a copy with you.. Asthma Control Test:. The Asthma Control Test (ACT) has questions for a person with asthma. Take the ACT and see if your asthma is under control. Share the results with your doctor. Page Updated: 12/7/2017 ...
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AUSTIN, Texas-A developmental biologist at The University of Texas at Austin has received a $450,000 grant from the Sandler Program for Asthma Research given to innovative scientists willing to step away from their area of research and tackle the rid
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Asthma preventer or controller medications are used to control asthma and lower the risk of disease exacerbations. These are typically inhaled corticosteroids, which may be delivered with a long-acting beta-agonist (LABA) or separately.
It is also an anti-asthmatic agent and a demethylized metabolite of caffeine. Small open-label trials suggest that theophylline ... Several xanthines and non-xanthines are under development as potential anti-parkinsonism agents, which are selective for A2A ... Some effects were found to be due to enhanced activity of natural killer cells and also due to enhanced efficacy of anti-PD-1 ... adenosine receptor ligands as anti-inflammatories and many more. Several attempts have been made by using virtual screening to ...
... anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents. A patent application for 4- ... A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. ...
Ciclosporin has been touted as a therapeutic option in moderate to severe asthmatic patients as a corticosteroid sparing agent ... These efforts probed the anti-inflammatory and immunosuppressive properties of ciclosporin after regional deposition of drug in ... It was originally used to prevent transplant rejection of solid organs but has also found use as an orally administered agent ... Evans, DJ; Cullinan, P; Geddes, DM (2001). "Cyclosporin as an oral corticosteroid sparing agent in stable asthma". Cochrane ...
... mimics the asthmatic hypersensitivity to agents that cause bronchoconstriction by increasing airway narrowing responses to ... Nixon, Jennifer B; Kim, Kyung-Su; Lamb, Patricia W; Bottone, Frank G; Eling, Thomas E (2004). "15-Lipoxygenase-1 has anti- ... This stimulation appears due to a direct interaction of these agents on TRPV1 although reports disagree on the potencies of the ... "Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation ...
... exacerbation of asthmatic bronchoconstriction and related symptoms, In extremely rare instances, asthmatic symptoms in response ... a sulfur dioxide-related agent, or an agent whose levels in alcohol beverages correlated positively with those of sulfur ... and by nonsteroidal anti-inflammatory drugs (NSAID) other than aspirin. The study suggested the salicylate-"contaminates" in ... tested the effects of alcoholic beverage consumption on the respiratory symptoms of 11 asthmatic subjects who gave a history of ...
When medications such as NSAIDs or aspirin block the COX-1 enzyme, production of thromboxane and some anti-inflammatory ... Ledford DK, Wenzel SE, Lockey RF (2014). "Aspirin or other nonsteroidal inflammatory agent exacerbated asthma". The Journal of ... Eosinophils isolated from the blood of aspirin-induced asthma subjects (as well as severe asthmatic patients) greatly ... March 2014). "Cross-reactivity to Acetaminophen and Celecoxib According to the Type of Nonsteroidal Anti-inflammatory Drug ...
... or etamiphyllin (INN) is a xanthine intended for use as an anti-asthma agent. It has shown poor to absent effects ... Vazquez, C; Labayru, T; Rodriguez-Soriano, J (1984). "Poor bronchodilator effect of oral etamiphylline in asthmatic children". ...
... tocolytic agents MeSH D27.505.954.796 - respiratory system agents MeSH D27.505.954.796.050 - anti-asthmatic agents MeSH D27.505 ... anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122.085 - anti-bacterial agents MeSH D27.505 ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tranquilizing agents MeSH D27.505.696.277.950.015 - anti-anxiety agents MeSH D27.505.696.277.950.025 - antimanic agents MeSH ...
... eicosanoids most often act as autocrine signaling agents to impact their cells of origin or as paracrine signaling agents to ... Inhibition of COX-1 and/or the inducible COX-2 isoforms, is the hallmark of NSAIDs (non-steroidal anti-inflammatory drugs), ... isolated from severe and aspirin-intolerant asthmatics was greater than that from healthy volunteers and mild asthmatic ... Heat-PGE2 is also a potent pyretic agent. Aspirin and NSAIDS-drugs that block the COX pathways and stop prostanoid synthesis- ...
Hyperforin has been shown to exhibit anti-inflammatory, anti-tumor, antibiotic and anti-depressant functions (PMID 17696442, ... Agents such as montelukast and zafirlukast block the actions of cysteinyl leukotrienes at the CysLT1 receptor on target cells ... These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients ... Anti-inflammatory mechanisms of hyperforin have been described as inhibition of cyclooxygenase-1 (but not COX-2) and 5- ...
Nonsteroidal anti-inflammatory agents/analgesics (NSAIAs), Nonsteroidal anti-inflammatory medicines (NSAIMs). Use. Pain, fever ... exacerbations of asthmatic and rhinitis (see aspirin-induced asthma) symptoms in individuals with a history of asthma or ... These agents may also cause kidney impairment, especially in combination with other nephrotoxic agents. Kidney failure is ... "Medications - non-steroidal anti-inflammatory drugs". Retrieved 2 February 2018.. *^ Lee A, Cooper MG, Craig JC, Knight JF, ...
These include for adults: antihistamines, antihistamine-decongestant combinations, benzonatate, anti asthmatic-expectorant- ... Agents whose purpose is to suppress coughing. Cold medicine. Cough medicine often contains cough suppressants and expectorants. ... Chang, AB; Peake, J; McElrea, MS (16 April 2008). "Anti-histamines for prolonged non-specific cough in children". The Cochrane ... anti inflammatories, and anticholinergics - and for children: antihistamines, decongestants for clearing the nose, or ...
Fluticasone works as a potent anti-inflammatory agent, inhibiting multiple cell types such as mast cells, eosinophils, ... and bone mineral density in asthmatic children when inhaled fluticasone is used for up to three months.[10] ... Fluticasone, a corticosteroid, is the anti-inflammatory component of the combination which decreases inflammation in the lungs ...
Nagata K (2004). "CRTH2". Journal of Biological Regulators and Homeostatic Agents. 17 (4): 334-7. PMID 15065763.. ... Mice genetically engineered to be deficient in DP2 (i.e. DP2−/-) mice are defective in mounting asthmatic responses in models ... and increased production of an anti-inflammatory cytokine (IL-10).[8] ... reduces allergen-induced airway responses in allergic asthmatics". Clinical & Experimental Allergy. 44 (8): 1044-52. doi: ...
There are also increased levels of MMP in the lungs of asthmatics. Since tumstatin is cleaved by MMP from the collagen in the ... Wang Shu-jing; Liu Xing-han; Ji Yu-bin; Chen Ning (6-8 July 2007). "The Effect of Tumstatin Anti-tumor Peptide on Proliferation ... Tumstatin is a protein fragment cleaved from collagen that serves as both an antiangiogenic and proapoptotic agent. It has ... Type-IV collagen is present in the basement membrane within normal lungs, and this is reduced in asthmatic patients. ...
External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. ... The treatment of EIB has been extensively studied in asthmatic subjects over the last 30 years, but not so in EIB.[ ... Some physicians prescribe inhaled anti-inflammatory mists such as corticosteroids or leukotriene antagonists, and mast cell ... However, there is no evidence supporting different treatment for EIB in asthmatic athletes and nonathletes.[16] ...
The first is named the early asthmatic response, and the latter the late asthmatic response. Bronchioconstriction can occur as ... Muscarinic antagonists (anti-cholinergics): Blocking the muscarinic acetylcholine receptors in pulmonary smooth muscle tissue ... In combination with mucous thinning agents such as Guaifenesin significant improvement in breathing can be accomplished. More ... Unlike the SABAs, these medications do not provide relief of acute symptoms or asthmatic attacks, and their benefits are ...
August 2002). "Long-term management of atopic dermatitis in infants with topical pimecrolimus, a nonsteroid anti-inflammatory ... Clinical research studies where the NHP has been utilized include investigations into erythropoiesis-stimulating agents, ... A randomised clinical trial to evaluate the effectiveness of an educational intervention developed for adult asthmatics in a ... "Systematic review of the impact of erythropoiesis-stimulating agents on fatigue in dialysis patients". Nephrology, Dialysis, ...
The potential of Dz13 as a therapeutic agent derives from the fact that inactivation of c-Jun can have an effect on downstream ... Anti-cancer effects have been also demonstrated in models of prostate cancer, breast cancer and osteosarcoma. Clinical trials ... Krug, N. et al (2015) Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med. 372(21):1987-95 ... 25(55): 7260-6. Tan, M.L. et al (2010) Direct anti-metastatic efficacy by the DNA enzyme Dz13 and downregulated MMP-2, MMP-9 ...
Triple therapy is then of all three groups and should the need arise then to add in a fourth agent, to consider either a ... Asthmatics have been reported to have worsening symptoms when using beta blockers. Benign prostatic hyperplasia may be improved ... Some indirect anti-adrenergics are rarely used in treatment-resistant hypertension: guanethidine - replaces norepinephrine in ... Antihypertensive+Agents at the US National Library of Medicine Medical Subject Headings (MeSH) Law M, Wald N, Morris J (2003 ...
Commonly taken twice a day with an anti-inflammatory medication, they maintain open airways and prevent asthma symptoms, ... TSG12 is a specific transgelin-2 (TG2)-agonist that relaxes airway smooth muscle cells and reduces asthmatic pulmonary ... Sathe NA, Krishnaswami S, Andrews J, Ficzere C, McPheeters ML (July 2015). "Pharmacologic Agents That Promote Airway Clearance ... airways and open up the airways in asthmatic lung tissues, researchers have identified a drug called TSG12. ...
"World Anti-Doping Agency. Retrieved 7 September 2017.. *^ a b Tortora, Gerard J.; Anagnostakos, Nicholas P. (1987). Principles ... External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. ... Burke, TV; Küng, M; Burki, NK (1989). "Pulmonary gas exchange during histamine-induced bronchoconstriction in asthmatic ...
"Sufjan Stevens , Asthmatic Kitty Records". "Bea Arthur , Jewish Women's Archive". "Sean Baker Tells Students There's 'No Set ... director of Anti-Defamation League Alice Mary Higgins, independent senator and member of the Irish Parliament Janine Jackson, ... New York real estate agent Bernard L. Schwartz Bradford Shellhammer, entrepreneur and designer, founding editor of Queerty ...
Howe biographer Julie M. Fenster describes the anti-Hearst campaign as a "personal turning point" for Howe, in which he got his ... He encouraged her to express herself in print as well, and acted for a time as her literary agent. After Franklin's 1932 ... Born to a wealthy family in Indianapolis, Indiana, Howe was a small, sickly, and asthmatic child. The family moved to Saratoga ... Roosevelt was successful, marking him as the new leader of the anti-Tammany "insurgents". Howe interviewed Roosevelt for the ...
Fruit acids, such as malic acid and tartaric acid, contribute to flavor enhancement and act as anti-microbial agents (suppress ... of asthmatics are also at risk of suffering an adverse reaction. Given that about 10% of the population suffers from asthma, ... Consequently, the FDA requires food manufactures and processors to disclose the presence of sulfiting agents in concentrations ...
Anti-leukotriene agents may be effective alone for adolescents and adults, however there is no clear research suggesting which ... Alcohol may worsen asthmatic symptoms in up to a third of people. This may be even more common in some ethnic groups such as ... Leukotriene receptor antagonists (anti-leukotriene agents such as montelukast and zafirlukast) may be used in addition to ... For adults or adolescents who have persistent asthma that is not controlled very well, the addition of anti-leukotriene agents ...
"Part 6: Advanced Cardiovascular Life Support Section 6: Pharmacology II: Agents to Optimize Cardiac Output and Blood Pressure ... "Nebulized racemic epinephrine used in the treatment of severe asthmatic exacerbation: a case report and literature review" ... World Anti-Doping Agency prohibited substances. *Peripherally selective drugs. *Respiratory therapy. Hidden categories: *CS1: ... contrast agents, medicines or people with a history of anaphylactic reactions to known triggers. A single dose is recommended ...
... long-acting agents are recommended.[2] Long-acting agents partly work by reducing hyperinflation.[74] If long-acting ... The 2018 NICE guidelines recommend use of ICS in people with asthmatic features or features suggesting steroid responsiveness. ... and act as anti-inflammatories. They show promise in decreasing the rate of exacerbations, but do not appear to change a ... External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. ...
Homozygous variants for this five repeat promoter region in a study of 624 asthmatic children in Ankara, Turkey were much more ... Aspirin and other non-steroidal anti-inflammatory drugs (NSAID) can cause NSAID-exacerbated diseases (N-ERD). These have been ... Alox5 and presumably human ALOX5 functions may vary widely depending on the agents stimulating their and types of metabolites ... have turned out to be effective anti-inflammatory drugs. Furthermore, blockers of LTC4, LTD4, and LTE4 synthesis (i.e. ALOX5 ...
Bronchoconstriction leads to asthmatic attacks and severe dyspnea, and bradycardia combined with marked hypotension and ... Muscarinic antagonists are often called parasympatholytics because they have the same effect as agents that block ... Treatment of the crude aldehyde with allyl bromide and zinc powder in water with NH4Cl as catalyst resulted in an anti:syn ...
... mimics the asthmatic hypersensitivity to agents that cause bronchoconstriction by increasing airway narrowing responses to ... Nixon, Jennifer B; Kim, Kyung-Su; Lamb, Patricia W; Bottone, Frank G; Eling, Thomas E (2004). "15-Lipoxygenase-1 has anti- ... This stimulation appears due to a direct interaction of these agents on TRPV1 although reports disagree on the potencies of the ... "Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation ...
World Anti-Doping Agency (September 19, 2005). "The World Anti-Doping Code: The 2006 Prohibited List International Standard" ( ... Agents specifically labeled for glaucoma *Betaxolol,[84] carteolol,[84] levobunolol,[84] timolol,[84] metipranolol[88] ... asthma guidelines recommend against the use of non-selective beta blockers in asthmatics, while allowing for the use of ... Agents with intrinsic sympathomimetic action (ISA) *Acebutolol,[81] pindolol,[81] labetalol,[81] mepindolol,[82] oxprenolol,[75 ...
Research indicates possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via downstream ... As tianeptine was the only agent known to both reduce free serotonin in plasma and enhance uptake in platelets, they decided to ... Institute of Experimental Medicine in Caracas published the results of a 52-week randomized controlled trial of asthmatic ... "The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist". Transl Psychiatry. 4: e411 ...
Three virus families, Influenzavirus A, B, and C are the main infective agents that cause influenza. During periods of cooler ... It is recommended that asthmatics and COPD patients be vaccinated against flu before the flu season. People with asthma can ... HIV patient who has been exposed to other people with influenza should see a physician to determine if there is a need for anti ... Each year flu related complications in the USA affect close to 100,000 asthmatics, and millions more are seen in the emergency ...
Triple therapy is then of all three groups and should the need arise then to add in a fourth agent, to consider either a ... Some indirect anti-adrenergics are rarely used in treatment-resistant hypertension: *guanethidine - replaces norepinephrine in ... Asthmatics have been reported to have worsening symptoms when using beta blockers. ... Aldosterone receptor antagonists are not recommended as first-line agents for blood pressure,[35] but spironolactone and ...
It is used as an anti-caking agent in powdered foods such as spices and non-dairy coffee creamer. It is the primary component ... Children, asthmatics of any age, those with allergies, and the elderly (all of whom have reduced lung capacity) can be affected ... Silica is a common additive in food production, where it is used primarily as a flow agent in powdered foods, or to adsorb ... Colloidal silica is also used as a wine, beer, and juice fining agent.[19] ...
... as an anti-fungal remedy, an anti-tumor drug and as a general ingredient to be used in protein engineering.[36] ... Zhu Z, Zheng T, Homer RJ, Kim YK, Chen NY, Cohn L, Hamid Q, Elias JA (June 2004). "Acidic mammalian chitinase in asthmatic Th2 ... Possible future applications of chitinases are as food additives to increase shelf life, therapeutic agent for asthma and ... Hunter MM, McKay DM (January 2004). "Review article: helminths as therapeutic agents for inflammatory bowel disease". ...
External agents/. occupational. lung disease. Pneumoconiosis Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's ... Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), particularly those that inhibit cyclooxygenase 1 (COX1), can ... "Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: A meta-analysis of the literature". The Journal ...
... with various oxidizing agents resulted in the evolution of N2 and CO2 gases. Using KBrO3 as the oxidizing agent resulted in the ... In this usage, a car Anti-lock Braking System (ABS) will qualify as an active-safety device, while both its seatbelts and ... However, some people with asthma may develop a potentially lethal asthmatic attack from inhaling the dust. ... as a Non-Azide Gas Generator for Safer Driving-the Thermal Behavior of the Sr Complex with Various Oxidizing Agents". ...
Although many ingredients do not contribute to the smell of a perfume, many perfumes include colorants and anti-oxidants to ... Evidence in peer-reviewed journals shows that some fragrances can cause asthmatic reactions in some individuals, especially ... it remains one of the few animalic fragrancing agents around which little controversy now exists. ...
For example, if gene splicing unites two pathogenic agents and the resulting novel organism infects a population. One study ... CD8+ cell noncytotoxic anti-HIV response, and the cytokines IL-10 and IL-16. median plasma levels of RANTES, a chemokine that ... epidemiologic studies indicating that children living along major trucking thoroughfares are at increased risk for asthmatic ... Uncovering the Associations Between Anti-gay Experiences, Psychosocial Issues, and HIV Risk. AIDS and Behavior epub ahead of ...
The particles act as a thixotropic thickening agent, or as an anti-caking agent, and can be treated to make them hydrophilic or ... Children, asthmatics of any age, those with allergies, and the elderly (all of whom have reduced lung capacity) can be affected ... It is used primarily as a flow or anti-caking agent in powdered foods such as spices and non-dairy coffee creamer, or powders ... Colloidal silica is used as a fining agent for wine, beer, and juice, with the E number reference E551. In cosmetics, silica is ...
The use of concurrent treatment with vancomycin or other beta-lactam agents may have a synergistic effect. Both CA-MRSA and HA- ... Moreover, the efficacy of vancomycin against MRSA is inferior to that of anti-staphylococcal beta-lactam antibiotics against ... severe asthmatics; etc.) Diabetics Intravenous drug users Regular contact with someone who has injected drugs in the past year ... This left vancomycin as the only effective agent available at the time. However, strains with intermediate (4-8 μg/ml) levels ...
"Anti-Asthmatic Agents" by people in Harvard Catalyst Profiles by year, and whether "Anti-Asthmatic Agents" was a major or minor ... "Anti-Asthmatic Agents" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Anti-Asthmatic Agents*Anti-Asthmatic Agents. *Agents, Anti-Asthmatic. *Anti Asthmatic Agents ... Below are the most recent publications written about "Anti-Asthmatic Agents" by people in Profiles. ...
Experimental study of a potential anti-asthmatic agent: SCH 15280.. L Diamond, G K Adams, B Bleidt and B Williams ... Experimental study of a potential anti-asthmatic agent: SCH 15280.. L Diamond, G K Adams, B Bleidt and B Williams ... Experimental study of a potential anti-asthmatic agent: SCH 15280.. L Diamond, G K Adams, B Bleidt and B Williams ... Experimental study of a potential anti-asthmatic agent: SCH 15280. Message Subject (Your Name) has forwarded a page to you from ...
Anti-Asthmatic Agents/chemical synthesis*. *Anti-Asthmatic Agents/chemistry. *Anti-Asthmatic Agents/pharmacology ... Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a ...
Anti-Asthmatic Agents - therapeutic use Asthma - diagnosis - epidemiology - therapy Cohort Studies Disease Management Female ... Anti-Asthmatic Agents - therapeutic use Asthma - diagnosis - drug therapy - physiopathology Data Mining Electronic Health ... data to create a real-world reference population of uncontrolled asthmatic patients to supplement the concurrent control/ ...
Anti-Asthmatic Agents - therapeutic use Asthma - diagnosis - drug therapy - epidemiology Attitude of Health Personnel ... Bronchodilator Agents - therapeutic use Chi-Square Distribution Confidence Intervals Cross-Sectional Studies Family Practice - ...
Have a diagnosis of aspirin or nonsteroidal anti-inflammatory drug-induced asthma ... A Prospective, Randomized, Double-Blind Study of the Efficacy of Omalizumab (Xolair) in Atopic Asthmatics With Good Lung ... A Prospective, Randomized, Double-Blind Study of the Efficacy of Omalizumab (Xolair) in Atopic Asthmatics With Good Lung ...
Anti-Asthmatic Agents. Respiratory System Agents. To Top. *For Patients and Families ... Beneficial Effects of Lactobacillus Reuteri DSM 17938 Supplementation on Asthmatic Children. The safety and scientific validity ... During the entire trial period the number of asthmatic exacerbations and the use of beta-2 antagonists will be monitored by a ... During the entire trial period the number of asthmatic exacerbations and the use of beta-2 antagonists will be monitored by a ...
... non-steroidal anti-inflammatory agents) or suggest an ongoing illness (such as antibiotics) ... Ozone can cause acute airway inflammation in both asthmatics and normal volunteers. However, in asthmatics ozone can cause ... aspirin or non-steroidal anti-inflammatory agents, corticosteroids, lactose, polyethylene glycol). *Positive pregnancy test at ... Effect of Ozone on Airway Inflammation in Allergic Asthmatics Treated With Omalizumab. The safety and scientific validity of ...
Anti-Asthmatic Agents. Respiratory System Agents. Leukotriene Antagonists. Hormone Antagonists. Hormones, Hormone Substitutes, ... Mild to moderate asthmatic children. Asthmatic children with pre-budesonide FEV1/FVC ≥ 80% will be included. ... The asthmatic children with and without food allergy will be given placebo and montelukast following one another in a cross ... Severe asthmatic children. *Any lung disease except asthma (i.e. cystic fibrosis, bronchiectasia, primary ciliary dyskinesia). ...
Anti-Asthmatic Agents / therapeutic use * Asthma / classification* * Asthma / drug therapy * Child * Child, Preschool ...
For prevention of acute bronchospasm which follows exercise, exposure to cold, dry air, or environmental agents, the usual ...
Anti-asthmatic Agents. Drugs that are used to treat asthma.. Orciprenaline. A beta-adrenergic agonist used in the treatment of ... If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the ... Home » Topics » Asthma » Research » The Effect of Single Dose Paracetamol on the Lower Airways of Asthmatic and Healthy ... The goal of this research is to identify and quantify the effect of single dose of paracetamol on lung functions of asthmatic ...
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the ... If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the ... Home » Topics » Relvar Ellipta » Research » Efficacy of QVAR vs Flovent Diskus on Small Airways in Poorly Controlled Asthmatic ... Efficacy of QVAR vs Flovent Diskus on Small Airways in Poorly Controlled Asthmatic Adolescents/Adult Patients. 2014-08-27 03:54 ...
Anti-Asthmatic Agents / administration & dosage* * Anti-Asthmatic Agents / pharmacokinetics * Asthma / diagnostic imaging ... Background: Fixed combination fluticasone-salmeterol is the most used anti-inflammatory asthma treatment in North America, yet ... Methods: A crossover study was conducted in asthmatic patients with commercial formulations of fluticasone-salmeterol and HFA ... delivered to asthmatic patients and examine the drug distribution within the lungs. The results were compared with the ...
Used in the management of symptoms of asthma. Also used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy ...
Anti-Inflammatory Agents. Additional Keywords : Phytotherapy, Plant Extracts. [+] Perilla seed oil demonstrates anti-asthmatic ... Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Gastroprotective. Problem Substances : Indomethacin, Non- ... Pharmacological Actions : Anti-Allergic Agents, Antidepressive Agents, Antimicrobial, Antioxidants. Additional Keywords : ... Pharmacological Actions : Anti-Bacterial Agents. Additional Keywords : Gene Expression Regulation, Multidrug Resistance, Plant ...
Anti-Asthmatic Agents*/adverse effects. *Anti-Asthmatic Agents*/therapeutic use. *Asthma*/drug therapy ...
Pharmacological Actions : Anti-Asthmatic Agents, Immunomodulatory. [+] O. humifusa supplementation might play an important role ... Pharmacological Actions : Anti-Apoptotic, Anti-Inflammatory Agents, Pancreato Protective Agents. Additional Keywords : Plant ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Neuroprotective Agents. Additional Keywords : Plant Extracts ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Apoptotic, Chemopreventive, Cyclooxygenase 2 Inhibitors. ...
Anti-Allergic Agents. Anti-Asthmatic Agents. Respiratory System Agents. To Top. *For Patients and Families ...
Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent. / Lawson, Edward C ... Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent. Bioorganic and ... Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent. ... title = "Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent", ...
Bronchodilator Agents. Autonomic Agents. Peripheral Nervous System Agents. Physiological Effects of Drugs. Anti-Asthmatic ... Respiratory System Agents. Free Radical Scavengers. Antioxidants. Neurotransmitter Agents. Endothelium-Dependent Relaxing ... However, it is unknown if the simultaneous use of sildenafil plus, at least, 3 classes of antihypertensive agents in patients ... However, it is unknown if the simultaneous use of sildenafil plus, at least, 3 classes of antihypertensive agents in patients ...
... anti-androgen agents; anti-anemic agents; anti-anginal agents; anti-anxiety agents; anti-arthritic agents; anti-asthmatic ... anti-emetic agents; anti-epileptic agents; anti-estrogen agents; anti-fibrinolytic agents; anti-fungal agents; anti-glaucoma ... anti-rheumatic agents; anti-schistosomal agents; anti-seborrheic agents; anti-spasmodic agents; anti-tartar and anti-calculus ... anti-keratinizing agents; anti-malarial agents; antimicrobial agents; anti-migraine agents; anti-mitotic agents; anti-mycotic ...
Pharmacological Actions : Anti-Asthmatic Agents. [+] Anti-cervical carcinoma effect of Portulaca oleracea L. polysaccharides by ... Pharmacological Actions : Anti-Inflammatory Agents, Hepatoprotective, Hypoglycemic Agents, Hypolipidemic, Interleukin-1 beta ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Hypoglycemic Agents, Interleukin-6 Downregulation, Tumor ... Pharmacological Actions : Anti-Inflammatory Agents, Interleukin-6 Downregulation, NF-kappaB Inhibitor, Tumor Necrosis Factor ( ...
It is also an anti-asthmatic agent and a demethylized metabolite of caffeine. Small open-label trials suggest that theophylline ... Several xanthines and non-xanthines are under development as potential anti-parkinsonism agents, which are selective for A2A ... Some effects were found to be due to enhanced activity of natural killer cells and also due to enhanced efficacy of anti-PD-1 ... adenosine receptor ligands as anti-inflammatories and many more. Several attempts have been made by using virtual screening to ...
... anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents. A patent application for 4- ... A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. ...
  • The aim of this study was to evaluate the feasibility of using electronic health record (EHR) data to create a real-world reference population of uncontrolled asthmatic patients to supplement the concurrent control/placebo group in long-term studies of asthma. (arctichealth.org)
  • However, in asthmatics ozone can cause episodes of worsening of asthma. (clinicaltrials.gov)
  • To do this we will examine the response to ozone in a group of asthmatics treated with omalizumab, a medicine available and approved for use in people with asthma, or a placebo control. (clinicaltrials.gov)
  • It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA. (bioportfolio.com)
  • Fixed combination fluticasone-salmeterol is the most used anti-inflammatory asthma treatment in North America, yet no studies report the actual respiratory tract dose or the distribution of drug within the lungs. (nih.gov)
  • From a number of potent α 4 β 1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route. (elsevier.com)
  • From a number of potent α4β1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route. (elsevier.com)
  • Compared to childhood-onset asthma, adult-onset asthma tends to be more continuous, while childhood asthma often is marked by asthmatic episodes followed by asthma-free periods. (thefreedictionary.com)
  • These agents are used to treat bronchospasm in acute asthmatic episodes, and used to prevent bronchospasm associated with exercise-induced asthma or nocturnal asthma. (medscape.com)
  • They are used for the preventive treatment of nocturnal asthma or exercise-induced asthmatic symptoms, for example. (medscape.com)
  • Salmeterol is the only single-agent LABA available in the United States that is approved for asthma. (medscape.com)
  • For the treatment of asthma, wheezing, and chronic asthmatic bronchitis. (drugbank.ca)
  • However, the proportion of 25OHD sufficient levels among asthmatics according to the Global Initiative for Asthma treatment steps 2, 3, and 4 was significantly different (8.6%, 16.6%, and 43.7%, respectively, p = 0.046). (cdc.gov)
  • Moreover, smoking may predict successful responses to some anti-asthma treatment, but not others, and improved phenotyping of patients with asthma who smoke will become increasingly important for the design of future clinical trials and for drug development. (ersjournals.com)
  • Ginkgolides were found to lack direct bronchodilating activity in clinical studies, but may have a role in the treatment of asthma due to their demonstrated anti-PAF activity. (townsendletter.com)
  • This study is designed to investigate the anti-asthmatic potential of KILE and monitor the accompanying histopathological and immunobiochemical changes that occur in an animal model of bronchial asthma using ovalbumin sensitized guinea pigs. (scirp.org)
  • During the past 10 years, pharmacological agents that specifically inhibit the LO-mediated signaling pathways are now commercially available to treat inflammatory diseases such as asthma, arthritis, and psoriasis. (aacrjournals.org)
  • Most asthmatic children in the Salvador urban area have persistent asthma. (scielo.br)
  • Purslane (P. olecracea) has a bronchodilatory effect in airways of asthmatic patients. (greenmedinfo.com)
  • Anti-Asthmatic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Broad reviews from 2006 have been focusing on adenosine receptors as therapeutic targets, adenosine receptor antagonists as potential therapeutics, antagonist for A2A-receptors, adenosine receptor ligands as anti-inflammatories and many more. (wikipedia.org)
  • 3 Although many authors have raised concerns about the use in international sports of prescribed substances such as β2-agonists, 4 non-steroidal anti-inflammatory drugs (NSAIDs), 5 - 7 corticosteroids, 8 and nutritional supplements, 9 10 only little is known about the magnitude of their current use. (bmj.com)
  • Ozone can cause acute airway inflammation in both asthmatics and normal volunteers. (clinicaltrials.gov)
  • This is most commonly used in rescue therapy for acute asthmatic symptoms. (medscape.com)
  • It has no anti-inflammatory action and is not indicated in the treatment of acute bronchospastic episodes. (medscape.com)
  • This review assessed the efficacy and safety of nebulisers, pressurised metered-dose inhalers and dry powder inhalers as delivery systems for beta-agonists, anticholinergic agents and corticosteroids. (york.ac.uk)
  • To compare the efficacy and safety of nebulisers, pressurised metered-dose inhalers (MDIs) with or without a spacer or holding chamber, and dry powder inhalers (DPIs) as delivery systems for beta-agonists, anticholinergic agents and corticosteroids. (york.ac.uk)
  • The medications delivered were mainly beta2-agonists, though there were some studies of corticosteroid and anticholinergic agents. (york.ac.uk)
  • To characterize the dose of fluticasone-salmeterol hydrofluoroalkane-134a (HFA) (particle size, 2.7 μm) delivered to asthmatic patients and examine the drug distribution within the lungs. (nih.gov)
  • A crossover study was conducted in asthmatic patients with commercial formulations of fluticasone-salmeterol and HFA beclomethasone radiolabeled with technetium Tc 99m. (nih.gov)
  • However, it is unknown if the simultaneous use of sildenafil plus, at least, 3 classes of antihypertensive agents in patients with resistant arterial hypertension may have a synergic effect on the patients blood pressure. (clinicaltrials.gov)
  • Hypothesis: The investigators hypothesize that the sildenafil, besides the anti-ischemic effect, will improve the patients hemodynamic status and, moreover, that it will occur a modulation of this effect by the T-786C polymorphism. (clinicaltrials.gov)
  • Three patients with TS who experienced incomplete responses to conventional anti-TS drugs but noted a significant amelioration of symptoms when smoking marijuana. (ukcia.org)
  • Boswellia serrata, a potent inhibitor of leukotriene production, has been successful in a clinical trial with asthmatic patients. (townsendletter.com)
  • The results of this study indicate that a dose of 2 gm/ day of Nigella sativa might be a beneficial adjuvant to oral hypoglycemic agents in type 2 diabetic patients. (mercola.com)
  • Other medications are available for special situations, other therapies (allergy shots, bronchial thermoplasty) in selected patients and lifestyle changes (treatment of gastroesophageal reflux disease, and weight loss in obese asthmatics) in others. (chieftain.com)
  • Pharmacologic management includes the use of control agents such as inhaled corticosteroids, inhaled cromolyn or nedocromil, long-acting bronchodilators, theophylline, leukotriene modifiers, and more recent strategies such as the use of anti-immunoglobulin E (IgE) antibodies (omalizumab), IL-5 monoclonal antibodies (mepolizumab, benralizumab), IL-4 receptor alpha monoclonal antibody (dupilumab), and long-acting antimuscarinic agents (LAMA) such as tiotropium. (medscape.com)
  • At the enrollment period all children have to show asthmatic symptoms and to be under antileukotrienes treatment (Montelukast 5mg/die) based on the GINA Guidelines. (clinicaltrials.gov)
  • To search the effects of montelukast on the airway inflammation including FEV1%, FEV1%/FVC, the provocholine® (methacoline chloride powder for inhalation) challenge tests, the leukotriene levels in the exhaled breath condensate in asthmatic children with and without food allergy aged 6-18 years old. (clinicaltrials.gov)
  • The asthmatic children with and without food allergy will be given placebo and montelukast following one another in a cross over design. (clinicaltrials.gov)
  • We here highlight the unique relationship between pharmacokinetics and anti-asthmatic activity of chalcone 4, a CXCL12 neutraligand. (ersjournals.com)
  • Other adults may be sensitive to aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen), or other drugs. (thefreedictionary.com)
  • CBD was found to be more effective than aspirin as an anti-inflammatory agent. (ukcia.org)
  • Removing medications that can cause problems in asthmatics, such as aspirin, non-steroidal anti-inflammatory agents and beta-blockers can prove helpful. (chieftain.com)
  • In persistent asthmatic and healthy control children, the 25OHD levels were measured using radioimmunoassay and SNPs (FokI, ApaI, and TaqI) were analyzed by a PCR-RFLP assay. (cdc.gov)
  • Asthmatics tend to have high leukotriene levels which cause bronchial restriction. (medindia.net)
  • The high intake of medication in international football - especially of non-steroidal anti-inflammatory drugs - is alarming and should be addressed. (bmj.com)
  • Recently published data on medication use in professional footballers indicate a high intake of both supplements 12 and non-steroidal anti-inflammatory drugs. (bmj.com)
  • Overall, the five drug classes mentioned most frequently for emergency department visits during 2004 were narcotic analgesics (30.7 million), non-steroidal anti-inflammatory drugs (25.2 million), non-narcotic analgesics (15.2 million), sedatives and hypnotics (10.4 million), and cephalosporins (8.2 million). (aahd.us)
  • The potential use of CBD as an anti-epileptic drug and its possible potentiating effect on other drugs are discussed. (ukcia.org)
  • This review discusses the clinical effects and the putative mode of anti-inflammatory action unrelated to H 1 receptor blockade of this class of drugs. (springer.com)
  • Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. (greenmedinfo.com)
  • Fluticasone propionate powder for inhalation administered twice daily to poorly controlled asthmatics. (bioportfolio.com)
  • Frusemide can also be used as a new antiasthmatic drug when administered by inhalation. (bmj.com)
  • To compare 25-hydroxyvitamin D (25OHD) levels and the frequency of 3 SNPs in the VDR gene between asthmatic and healthy children. (cdc.gov)
  • About 75 asthmatic (median age: 9.1 years) and 227 healthy children (10.3 years) were studied. (cdc.gov)
  • 25OHD sufficiency status was similar in asthmatic and healthy children (p = 0.57). (cdc.gov)
  • Other uses for the derivatives are: anti-asthmatic, antibacterial, anti-fungal, anti-malarial, antiviral and anti-inflammatory agents. (wikipedia.org)
  • Rosemaric acid exhibits anti-oxidant, anti-inflammatory, and analgesic effects. (medindia.net)
  • The traditional use of Cannabis as an analgesic, anti-asthmatic, and anti-rheumatic drug is well established. (ukcia.org)
  • Here, the seeds were used in conjunction with regular anti-diabetic medications. (mercola.com)
  • Some effects were found to be due to enhanced activity of natural killer cells and also due to enhanced efficacy of anti-PD-1 and anti-CTLA4 antibodies. (wikipedia.org)
  • The goal of this research is to identify and quantify the effect of single dose of paracetamol on lung functions of asthmatic and healthy subjects. (bioportfolio.com)
  • Experimental study of a potential anti-asthmatic agent: SCH 15280. (aspetjournals.org)
  • This Brazilian study Investigates the possible anti-psychotic activity of CBD by studying the effect of this cannabinoid on animal models used in research with potential anti-psychotic properties. (ukcia.org)
  • Conclusion: This study demonstrates the anti-asthmatic potential of KILE during prolonged administration by the oral route. (scirp.org)
  • According to a recent animal study published in July 2011 , cumin appears to have anti-stress properties. (mercola.com)
  • This study provides scientific support for the anti-stress, antioxidant, and memory-enhancing activities of cumin extract and substantiates that its traditional use as a culinary spice in foods is beneficial and scientific in combating stress and related disorders. (mercola.com)
  • A study published earlier this year concluded that black cumin's anti-diabetic effects appear to be rooted in its ability to improve insulin sensitivity. (mercola.com)
  • Anti-nociceptive and anti-inflammatory effects of the methanolic extract of Opuntia humifusa stem. (greenmedinfo.com)
  • Two health benefits that may be of particular interest to a majority of people are its anti-diabetic and anti-asthmatic effects. (mercola.com)
  • In addition, both in vitro and animal studies suggest that second-generation antihistamines may also show anti-inflammatory effects unrelated to H 1 receptor antagonism. (springer.com)
  • Several xanthines and non-xanthines are under development as potential anti-parkinsonism agents, which are selective for A2A receptors. (wikipedia.org)
  • Magnesium has a potential of being a bronchodilating agent. (medindia.net)
  • RWJ 22108 (N-benzyl-N-methylaminoethyl 9-(2-chloro-6-fluorophenyl)-2,3,4,5,6,9-hexahydro-7-methyl-1,1-dioxothiacyclohepteno-[3,2-b]pyridine-8-carboxylate) is a new bronchoselective calcium entry blocker with potential use as an antiasthmatic agent. (elsevier.com)
  • A variety of derivatives of 4-aminoquinoline are antimalarial agents useful in treating erythrocytic plasmodial infections. (wikipedia.org)
  • This graph shows the total number of publications written about "Anti-Asthmatic Agents" by people in Harvard Catalyst Profiles by year, and whether "Anti-Asthmatic Agents" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Anti-Asthmatic Agents" by people in Profiles. (harvard.edu)
  • An aqueous extract of purslane has anti-anging activity. (greenmedinfo.com)
  • Agents that block LO-catalyzed activity may be effective in preventing cancer by interfering with signaling events needed for tumor growth. (aacrjournals.org)
  • These well-characterized agents, representing two general drug effect mechanisms, are considered good candidates for clinical chemoprevention studies. (aacrjournals.org)
  • A beta blocking agent used to treat hypertension and aid in the management of heart failure. (drugbank.ca)
  • Thus, for example, the finding of pANCA in a systemic vasculitic condition arising initially as an asthmatic condition and found to also manifest tissue and blood eosinophilia makes a strong case for the diagnosis of CSD (which invariably involves the lungs). (medscape.com)
  • Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=285649&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=285649&idtype=1&closed=1" closed clinical trials using this agent. (fpnotebook.com)
  • A number of studies have also indicated that cumin may be helpful for asthmatics. (mercola.com)
  • and (5) for diabetes, hypoglycemic agents (261,000). (aahd.us)
  • Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylna. (nih.gov)