A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The characteristic three-dimensional shape of a molecule.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
Antibodies produced by a single clone of cells.
Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.
A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).
A nucleoside consisting of the base guanine and the sugar deoxyribose.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Cytosine nucleotides which contain deoxyribose as the sugar moiety.
A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Adenine nucleotides which contain deoxyribose as the sugar moiety.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Use of plants or herbs to treat diseases or to alleviate pain.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
The structure of one molecule that imitates or simulates the structure of a different molecule.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
The rate dynamics in chemical or physical systems.
Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
A cell line derived from cultured tumor cells.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Substances that reduce or suppress INFLAMMATION.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Elements of limited time intervals, contributing to particular results or situations.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
An encapsulated lymphatic organ through which venous blood filters.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
Proteins prepared by recombinant DNA technology.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The sum of the weight of all the atoms in a molecule.
Computer-based representation of physical systems and phenomena such as chemical processes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast. (1/477)

BACKGROUND: Inflammatory and immunological responses of vascular cells have been shown to play a significant role in the progression of atheromatous formation. Tranilast [N-(3,4-dimethoxycinnamoyl) anthranillic acid] inhibits release of cytokines and chemical mediators from various cells, including macrophages, leading to suppression of inflammatory and immunological responses. This study tested whether tranilast may suppress atheromatous formation in Watanabe heritable hyperlipidemic (WHHL) rabbits. METHODS AND RESULTS: WHHL rabbits (2 months old) were given either 300 mg x kg-1 x d-1 of tranilast (Tranilast, n=12) or vehicle (Control, n=13) PO for 6 months. Tranilast treatment was found to suppress the aortic area covered with plaque. Immunohistochemical analysis showed that there was no difference in the percentage of the RAM11-positive macrophage area and the frequency of CD5-positive cells (T cells) in intimal plaques between Tranilast and Control. Major histocompatibility complex (MHC) class II expression in macrophages and interleukin-2 (IL-2) receptor expression in T cells, as markers of the immunological activation in these cells, was suppressed in atheromatous plaque by tranilast treatment. Flow cytometry analysis of isolated human and rabbit peripheral blood mononuclear cells showed that an increase in expression both of MHC class II antigen on monocytes by incubation with interferon-gamma and of IL-2 receptor on T cells by IL-2 was suppressed by the combined incubation with tranilast. CONCLUSIONS: The results indicate that tranilast suppresses atherosclerotic development partly through direct inhibition of immunological activation of monocytes/macrophages and T cells in the atheromatous plaque.  (+info)

Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery. (2/477)

BACKGROUND: Activation of vascular chymase plays a major role in myointimal hypertrophy after vascular injury by augmenting the production of angiotensin (ANG) II. Because chymase is synthesized mainly in mast cells, we assumed that the chymase-dependent ANG II formation could be downregulated by tranilast, a mast cell-stabilizing antiallergic agent. We have assessed inhibitory effects of tranilast on neointima formation after balloon injury in the carotid artery of dogs, which share a similar ANG II-forming chymase with humans, and further explored the pathophysiological significance of vascular chymase. METHODS AND RESULTS: Either tranilast (50 mg/kg BID) or vehicle was orally administered to beagles for 2 weeks before and 4 weeks after balloon injury. Four weeks after the injury, remarkable neointima was formed in the carotid arteries of vehicle-treated dogs. Chymase mRNA levels and chymaselike activity of vehicle-treated injured arteries were increased 10.2- and 4.8-fold, respectively, those of uninjured arteries. Angiotensin-converting enzyme (ACE) activity was slightly increased in the injured arteries, whereas ACE mRNA levels were not. Tranilast treatment completely prevented the increase in chymaselike activity, reduced the chymase mRNA levels by 43%, and decreased the carotid intima/media ratio by 63%. In vehicle-treated injured arteries, mast cell count in the adventitia showed a great increase, which was completely prevented by the tranilast treatment. Vascular ACE activity and mRNA levels were unaffected by tranilast. CONCLUSIONS: Tranilast suppressed chymase gene expression, which was specifically activated in the injured arteries, and prevented neointima formation. Suppression of the chymase-dependent ANG II-forming pathway may contribute to the beneficial effects of tranilast.  (+info)

Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. (3/477)

To investigate the roles of calcium-binding proteins in degranulation, we used three anti-allergic drugs, amlexanox, cromolyn and tranilast, which inhibit IgE-mediated degranulation of mast cells, as molecular probes in affinity chromatography. All of these drugs, which have different structures but similar function, scarcely bound to calmodulin in bovine lung extract, but bound to the same kinds of calcium-binding proteins, such as the 10-kDa proteins isolated in this study, calcyphosine and annexins I-V. The 10-kDa proteins obtained on three drug-coupled resins and on phenyl-Sepharose were analysed by reversed-phase HPLC. It was found that two characteristic 10-kDa proteins, one polar and one less polar, were bound with all three drugs, although S100A2 (S100L), of the S100 family, was bound with phenyl-Sepharose. The cDNA and deduced amino acid sequence proved our major polar protein to be identical with the calcium-binding protein in bovine amniotic fluid (CAAF1, S100A12). The cDNA and deduced amino acid sequence of the less-polar protein shared 95% homology with human and mouse S100A13. In addition, it was demonstrated that the native S100A12 and recombinant S100A12 and S100A13 bind to immobilized amlexanox. On the basis of these findings, we speculate that the three anti-allergic drugs might inhibit degranulation by binding with S100A12 and S100A13.  (+info)

Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers. (4/477)

AIMS: To study whether desensitization occurs after long-term administration of the 1-adrenoceptor partial agonist xamoterol and, if so, whether this can be influenced by ketotifen. METHODS: In a double-blind, randomized design 10 young, healthy males received ketotifen (2 x 1 mg day(-1) p.o.) or placebo for 3 weeks with xamoterol (2 x 200 mg day(-1) p.o.) administered concomitantly during the last 2 weeks. 'l1-adrenoceptor mediated responses were assessed as exercise-induced tachycardia and isoprenaline-induced shortening of heart rate corrected electromechanical systole (QS2c); isoprenaline-induced tachycardia was measured as a mixed beta1-/beta2-adrenoceptor-mediated effect. RESULTS: The first dose of xamoterol significantly increased resting heart rate and systolic blood pressure and significantly shortened QS2c. The last dose of xamoterol after 2 weeks of treatment still produced the same responses. Ketotifen did not influence these effects of xamoterol on resting haemodynamics. The first dose of xamoterol caused a rightward shift of the exercise- and isoprenaline-induced tachycardia (mean dose ratios+/-s.e.mean: 1.20+/-0.05 and 2.46+/-0.23) and the isoprenaline-evoked shortening of QS2c (dose ratio 3.59+/-0.68). This rightward shift was even more pronounced after 2 weeks xamoterol treatment. This additional rightward shift after 2 weeks of xamoterol was not affected by ketotifen (mean difference (95% CI) of log transformed dose ratios between placebo and ketotifen: exercise tachycardia 0.001 (-0.03; 0.04); isoprenaline tachycardia 0.03 (-0.15; 0.21); isoprenaline induced shortening of QS2c 0.13 (-0.22; 0.48)). CONCLUSIONS: In humans xamoterol is a partial beta1-adrenoceptor agonist with positive chrono- and inotropic effects at rest and antagonistic properties under conditions of beta-adrenoceptor stimulation. These effects were well maintained after chronic dosing with no signs of beta1-adrenoceptor desensitization. Ketotifen does not change the beta-adrenoceptor mediated responses of xamoterol after chronic dosing.  (+info)

Comparison of intranasal triamcinolone acetonide with oral loratadine in the treatment of seasonal ragweed-induced allergic rhinitis. (5/477)

A double-blind, randomized, multicenter, parallel-group controlled study compared the efficacy and safety of intranasal triamcinolone acetonide (220 micrograms/day) and oral loratadine (10 mg/day) in patients with at least two seasons of ragweed-induced seasonal allergic rhinitis. A 28-day screening period, including a 5-day baseline period, preceded a 4-week treatment period. Reduction in rhinitis symptom scores was evident in both groups as early as day 1, with no significant between-group differences during week 1. At weeks 2, 3, and 4, patients treated with triamcinolone acetonide were significantly (P < 0.05) more improved in total nasal score, nasal itch, nasal stuffiness, and sneezing than were patients treated with loratadine. At weeks 3 and 4, rhinorrhea and ocular symptoms were significantly (P < 0.05) more improved from baseline among triamcinolone acetonide patients compared with loratadine patients. There was no significant between-group difference in relief from postnasal drip at any time point. Physicians' global evaluations significantly (P = 0.002) favored triamcinolone acetonide at the final visit, with moderate to complete relief of symptoms attained by 68% of triamcinolone acetonide patients and 59% of loratadine patients. Over the 4-week treatment period, triamcinolone acetonide patients had significantly greater improvement in total nasal score, nasal itch, nasal stuffiness, sneezing, and ocular symptoms. Both treatments were well tolerated, with headache being the most frequently reported drug-related adverse effect in both the triamcinolone acetonide (15%) and loratadine (11%) groups. These results indicate that triamcinolone acetonide is more effective than oral loratadine in relieving the symptoms of ragweed-induced seasonal allergic rhinitis.  (+info)

Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. (6/477)

Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. Despite a steady increase in the incidence, morbidity, and mortality from asthma, no current treatment can reduce or prevent asthma for a prolonged period. We examined the ability of unmethylated CpG oligodeoxynucleotides (ODN), which are potent inducers of Th1 cytokines, to prevent the inflammatory and physiological manifestations of asthma in mice sensitized to ragweed allergen. Administration of CpG ODN 48 h before allergen challenge increased the ratio of IFN-gamma to IL-4 secreting cells, diminished allergen-induced eosinophil recruitment, and decreased the number of ragweed allergen-specific IgE-producing cells. These effects of CpG ODN were sustained for at least 6 wk after its administration. Furthermore, there was a vigorous Th1 memory response to the recall Ag, inhibition of peribronchial and perivascular lung inflammation, and inhibition of bronchial hyperresponsiveness 6 wk after administration of CpG ODN. Administration of CpG ODN in IFN-gamma -/- mice failed to inhibit eosinophil recruitment, indicating a critical role of IFN-gamma in mediating these effects. This is the first report of a treatment that inhibits allergic lung inflammation in presensitized animals for a prolonged period and thus has relevance to the development of an effective long term treatment for asthma.  (+info)

Adhesive explant culture of allergic nasal mucosa: effect of emedastine difumarate, an anti-allergic drug. (7/477)

Allergic reaction of the nose comprises of an immediate and a late reaction. To evaluate nasal allergic reactions, many experiments have been performed by investigators. In this study, we performed a new tissue culture technique (adhesive explant culture) to analyze the migration of cells into the culture medium from the cultured allergic nasal mucosa in response to an allergen. Basophilic cells (mast cells and basophils) and eosinophils, which were released into the culture medium after the allergen challenge, were evaluated by the analysis of histamine and eosinophil cationic protein (ECP) content in the culture medium. Histamine and basophilic cells in the culture medium were more abundant in the immediate phase (within 30 min) after challenge than in the late phase (from 30 min to 10 hr). On the other hand, ECP and eosinophils in the culture medium were more abundant in the late phase than in the immediate phase. The increase of histamine content in both phases were not inhibited by pre-treatment of emedastine difumarate (EME), an anti-allergic drug. However, the increase of ECP in the late phase was inhibited by pre-treatment with EME. Moreover, the number of EG2-positive cells was also decreased by pre-treatment with EME. These results suggest that EME might lower the activation of eosinophils in the late phase of the allergic reaction. The present study also indicates that this adhesive explant culture system is useful model for studying the cellular allergic responses to drugs ex vivo.  (+info)

Effect of an orally active Th1/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice. (8/477)

We have found a novel anti-allergic agent, M50367, which suppresses IgE biosynthesis and eosinophil accumulation in vivo. In this study, we evaluated the ability of M50367 to modulate Th1/Th2 balance in Th2-background BALB/c mice and to inhibit airway hyperresponsiveness in a murine model of atopic asthma. Oral M50367 at 3-30 mg/kg/day exhibited 51 to 73% reduction of IL-4/IL-5 production and 2- to 5-fold augmentation of IFN-gamma production by Ag-stimulated cultured splenocytes of the mice sensitized with DNP-Ascaris. These alterations in Th1/Th2 cytokine production were accompanied by 55-85% suppression of plasma IgE level. Oral M50367 at a dose of 10 mg/kg/day significantly inhibited Ig-independent peritoneal eosinophilia by 54%, which was induced by repeated i.p. injections of Ascaris suum extract. To develop airway hyperresponsiveness caused by allergic airway inflammation, BALB/c mice were sensitized with i.p. OVA injections, followed three times by OVA inhalation. Oral M50367 significantly inhibited the increase in airway reactivity to acetylcholine, together with the elevation of plasma IgE level and pulmonary eosinophilia, which were observed in vehicle-treated mice 1 day after the last inhalation. Moreover, M50367 treatment reduced IL-4 and IL-5 production and tended to enhance IFN-gamma production, not only by cultured splenocytes, but also in bronchoalveolar lavage fluid. These results suggest that M50367 has a modulating ability of Th1/Th2 balance to down-regulate Th2 response in the circulating system as well as at the sites of inflammation, and may be beneficial for the treatment of allergic disorders such as atopic asthma.  (+info)

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The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated protein kinase inhibitor, SB 239063 [trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole], was investigated in vivo and in vitro. SB 239063 had an IC50 of 44 nM for inhibition of recombinant purified human p38α. In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-α production (IC50 values = 0.12 and 0.35 μM, respectively). A role for p38 kinase in cytokine-associated inflammation in the mouse was shown by p38 activation in the lung and inhibition of lipopolysaccharide-induced tumor necrosis factor-α production by SB 239063 (ED50 = 5.8 mg/kg p.o.). Antiallergic activity was demonstrated by essential abolition (∼93% inhibition) of inhaled ovalbumin (OA)-induced airway eosinophilia by SB 239063 (12 mg/kg p.o.), measured by bronchoalveolar lavage (BAL) in OA-sensitized mice. In addition, p38 ...
Methods: Female Balb/c mice were sensitized with 200 μl 0.5% DNCB for three days. After sensitization, mice were challenged with 200 μl 1% DNCB on the same dorsal skin and also 20 μl 1% DNCB on each ear every 3 days, and orally administrated by gavage with DCE (0.6, 1.2 and 2.4 g/kg) daily from day 14 to day 29 for 16 consecutive days. At the end of experiment, the clinical scores for AD on the mice were calculated to evaluate the therapeutic effect of DCE; and serum, ears and dorsal skin of the mice were collected for mechanistic study. The anti-allergic activity of DCE was also evaluated using antigen-induced RBL-2H3 cell line. The release of selected cytokines, chemokines and β-hexosaminidase was measured to determine the anti-allergic activity of DCE. In addition, intracellular Ca2+ level, MAPKs and Lyn phosphorylations were further investigated to reveal its anti-allergic molecular mechanisms ...
Guest Editors who wish to submit an issue proposal to Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry are requested to complete the following online form. The proposal of thematic issue will then be immediately forwarded to the Editor-in-Chief/Co-Editors/Executive Editor(s) of Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry who will then inform Guest Editors with a decision about the submitted proposal.. ...
Clinical Anti-Inflammatory & Anti-Allergy Drugs publishes original research, expert reviews, drug clinical trials and thematic issues in all core areas of translational and clinical anti-inflammatory & anti-allergy drug research.
Allergies can be topical, respiratory, or digestive, and result in an immune system overreaction to a substance. This can release histamines, which cause wheezing, rashes, sneezing, vomiting, and even anaphylactic shock. People can be allergic to specific foods, plants, animals, and chemicals. Human studies are lacking, and more research is necessary on the anti-allergy potential of various herbs.. Hay fever is a seasonal allergy to pollens and fungi in the air, and can irritate the nose, throat, and eyes. ...
The anti-allergy drug FPL 52757 (Fisons Ltd. ,) 6,8-diethyl-5-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid produced mild and reversible hepatotoxicity in some patients during clinical trials. The purpose of this work was to elucidate the mechanism by which FPL 52757 caused hepato-toxicity. However, since further humans could not be tested the work is limited to animal models. Toxicity studies showed that the beagle dog was the only animal species of ten tested which was readily susceptible to the hepatotoxic effect of the compound. In this project hepatotoxicity could not be demonstrated in ferrets or rats in special studies designed to reduce resistance to drug-induced hepatotoxicity. Similarly, hepatic microsomal enzyme induction in dogs by pretreatment with phenobarbitone and protection against cytotoxicity by pretreatment with methionine provided no evidence for involvement of a reactive metabolite in the hepatoxicity. Work by Fisons and additional studies in this project showed that the ...
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INDICATIONS. Haridra has many medicinal properties - it is a well-known herb that helps in combating allergy effectively. It has anti-inflammatory and anti-allergic activity. It helps in faster wound healing and has blood-purifying properties. It also acts as a carminative, stomachic, appetizer and tonic.. INSTRUCTIONS. Take exactly as recommended by your Health Provider.. If you miss a dose of Haridra and you are using it regularly, use it as soon as possible. Do not use 2 doses at once.. DOSAGE. Take 1 capsule twice a day after meals.. STORAGE. Store at the room temperature away from moisture and sunlight. Keep out of reach of children.. SAFETY INFORMATION. There are no know precautions for using Haridra.. SIDE EFFECTS. Haridra isnt known to have any side effects if taken as per the prescribed dosage. ...
Adenosine potentiated anaphylactic histamine release from isolated rat mast cells in a dose-dependent manner between 10−8 and 10−5 M. Adenosine was found to be present during a normal incubation of...
Allergic disease decreases the daily quality of life of many people, and can increase the number of working days lost owing to sick leave. Associated symptoms with allergic disease depend on the origin of the disease, and can either be allergic, non-allergic and purulent, or can cause rhinitis as a result of a common cold. Treatment depends on the origin of the rhinitis. However, an antihistamine is indicated in most instances. Combination treatment includes sympathomimetic drugs (either local or systemic) and corticosteroid medication (when indicated, and in most instances, used locally). The article provides an overview of the nature and the management of allergic disease and the histamine 1 antihistamines.
A variety of anti-allergy medications are generally administered. ACEI edema appears to be an allergic reaction, but it is not mediated by mast cell degranulation; therefore, the efficacy of usually effective anti-allergy drugs such as epinephrine, antihistamines, and corticosteroids is unlikely and remains unproven. No randomized controlled blinded studies have compared these medications, probably because most physicians quickly give all three. The edema generally lasts 24-72 hours and spontaneously subsides if the ACEI is halted. Standard anti-allergy medications have not been noted to be harmful, but no current evidence recommends for or against using any of them to treat ACEI angioedema.. Angioedema of the upper airway and larynx can be life-threatening. It is an ominous finding indicative of a severe process, and often requires ICU admission. The authors suggest the early use of fiber optic examination to determine the presence and extent of laryngeal involvement, and note that no patient ...
Tranilast is is an antiallergic drug. In-vitro it reduces collagen synthesis in fibroblasts,[2] and inhibits growth of neurofibroma cells. In-vitro it inhibits the production of interleukin-6 in endothelial cells ...
Olopatadine 0.2% is a well-tolerated, safe, and effective antihistamine/mast cell stabilizer for treating mild to severe allergic conjunctivitis in children and adults.
Sujiaonori, a river alga growing in the Kochi prefecture, Japan, contains several bioactive compounds such as sulfated polysaccharides (ulvans), ω-3 fatty acids, and vitamins. Dietary intake of this alga-based supplement has been reported to increase circulatory adiponectin, a salutary hormone that is reported to be associated with healthy longevity and prevents a number of cardiovascular and metabolic disorders. This report highlights the anti-allergic and skin health enhancing effects of Sujiaonori-derived ulvan (Tosalvan) and supplement, respectively. RBL-2H3 cell line was used to investigate the anti-allergic effect of algal SP through the evaluation of β-hexosaminidase activity. Algal sulfated polysaccharides or SP (Tosalvan, Yoshino SP) were extracted from powders of dried alga samples provided by local food manufacturers. Report on the effect of daily dietary intake of Sujiaonori-based supplement on skin health is part of a four-week clinical investigation that, in comparison with a supplement
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If you struggle with allergy symptoms like a stuffy, runny nose, sneezing, irritable eyes or an itchy throat, youre not alone - around one in five people in Australian and New Zealand suffer from allergic rhinitis.[1]. ...
Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma ...
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Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to something in the environment that usually causes little or no problems to most people. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing and a runny nose, shortness of breath or swelling. Food intolerances and food poisoning are separate conditions.
While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known. We examined the effect of 70% ethanol extract of Chaga mushroom (EE) and its dichloromethane (DF) and aqueous (AF) fractions using a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and found that only EE and DF ameliorated allergy symptoms to a significant extent. The in vivo mast cell-stabilizing activity was also found only in EE and DF whereas the activities to suppress Th2 and Th17 immune responses and cOVA-specific IgE production in the small intestine were observed in all three treatment regimens, implying that inhibition of the mast cell function by lipophilic compounds was vital for the therapeutic effect ...
At recommended doses, has a pronounced anti-inflammatory, anti-edema and anti-allergic effect. Anti-inflammatory effect is realized by the interaction of the drug with the receptors glucocorticosteroids. Inhibits proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils, reduces the production and release of mediators of inflammation and other testosterone cypionate vs enanthate biologically active agents (including histamine, prostaglandins, leukotrienes,… ...
It has been used for many centuries as a treatment for ailments. It is also used to reduce cholesterol and blood pressure. It is believed to have anti-allergic properties, and is used as a remedy for arteriosclerosi. It also relieves spasms of the smooth muscle in the walls of the internal organs, making it valuable for gallbladder problems. Researchers have found it to be mildly antiseptic as well.. ...
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Title:Anti-inflammatory and Anti-Allergic Properties of Donkey's and Goat's Milk. VOLUME: 14 ISSUE: 1. Author(s):Felicita Jirillo and Thea Magrone. Affiliation:University of Bari, Policlinico, Piazza G. Cesare, 11-70124, Bari, Italy.. Keywords:Allergy, cow, donkey, elderly, goat, microbiota, milk.. Abstract:Nowadays, donkeys and goats milk consumption has been reevaluated for its potential benefits to human health. For example, in infants with intolerance to cows milk, donkeys milk represents a good alternative due to its chemical characteristics similar to those of human milk. On the other hand, goats milk in virtue of its higher content in short chain, medium chain, mono and polyunsaturated fatty acids than that of cows milk, is more digestible than the bovine counterpart. From an immunological point of view, donkeys milk is able to induce release of inflammatory and anti-inflammatory cytokines from normal human peripheral blood lymphomononuclear cells, thus maintaining a ...
Probiotic bacteria exert positive effects on human health. Among a wide range of health beneficial effects, the anti-allergic effect is an important one. One indication of allergic reaction is the increase in IgE level in our body. The mechanism initialized by probiotic bacteria leads to the decrease of IgE level that ultimately inhibits the allergic reactions. The present study is aimed to screen anti-allergic effect of native probiotics isolated from nectar. The probiotic bacteria were isolated from the nectar sample collected from Rangpur district of Bangladesh. The isolated probiotic bacteria were then subjected to morphological and biochemical tests. These morphological and biochemical tests allowed us to ensure that the isolated bacteria were the probiotic type. Then animal trial was conducted using these probiotic isolates. In the study, mice were used as the animal model. At the end of the trial, the blood samples isolated from different mice groups were analyzed. It has been found that, ...
TY - JOUR. T1 - Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice. AU - Shieh, Ying Hua. AU - Huang, Huei Mei. AU - Wang, Ching Chiung. AU - Lee, Chen Chen. AU - Fan, Chia Kwung. AU - Lee, Yueh Lun. PY - 2015. Y1 - 2015. N2 - Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and traditional medicine. Zerumbone was shown to possess anticarcinogenic, anti-inflammatory, and antioxidant properties. However, the antiallergic activity and the underlying mechanism of zerumbone have not been reported. Herein, we investigated the immunomodulatory effects of zerumbone on antigen-presenting dendritic cells (DCs) in vitro and its potential therapeutic effects against ovalbumin (OVA)-induced T helper 2 (Th2)-mediated asthma in mice. In the presence of zerumbone, lipopolysaccharide-activated bone marrow-derived DCs enhanced T cell proliferation ...
Reilly SM, Chiang SH, Decker SJ, et al. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21. PMID: 23396211.. Bell J. Amlexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig. 2005;25(9):555-66. PMID: 17532700.. Landriscina M, Prudovsky I, Mouta Carreira C, et al. Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro. J Biol Chem. 2000 Oct 20;275(42):32753-62. PMID: 10921913.. Shishibori T, Oyama Y, Matsushita O, Yet al. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Biochem J. 1999 Mar 15;338 ( Pt 3):583-9. PMID: 10051426.. Makino H, Saijo T, Ashida Y, et al. Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of ...
Top Quality 99% Amlexanox Cas:68302-57-8 Amlexanox English name: Amlexanox Amlexanox CAS Number: 68302-57-8 Amlexanox Molecular formula: C16H14N2O4 Amlexanox Molecular weight: 298.29 Amlexanox EINECS number: Amlexanox Related categories:...
Epinastine 0.05% eye drops are used for ocular itching associated with conjunctivitis. Order at our pharmacy and save upto $56.98.
Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population.
The present study is to investigate the effect of cornuside on mast cell-mediated allergic response, as well as its possible mechanisms of action.To test the anti-allergic effects of cornuside in vivo, local extravasation was induced by local injection of anti-dinitrophenyl immunoglobulin E (IgE) followed by intravenous antigenic challenge in passive cutaneous anaphylaxis model rats. Mast cell via ...
KIOM-MA128, a novel herbal medicine, has been reported to exert some beneficial effects on various biological events, such as atopic dermatitis, inflammation and cancer. The aim of this study is to investigate how KIOM-MA128 regulates the allergic response. We measured the activity of β-hexosaminidase and the levels of allergic mediators in the conditioned media of antigen/IgE (Ag/IgE)-activated RBL-2H3 mast cells. We examined the levels of proteins associated with both the FcεRI and arachidonate cascades. Finally, we established the passive cutaneous anaphylaxis (PCA) model in mice to confirm the anti-allergic effects of KIOM-MA128 in vivo. KIOM-MA128 dose-dependently inhibited degranulation and the production of the allergic mediators described above, with no significant cytotoxicity. In the arachidonate cascade, KIOM-MA128 significantly reduced both cytosolic phospholipase A2 (cPLA2) phosphorylation and cyclooxygenase-2 (COX-2) expression. Moreover, in the FcεRI cascade, KIOM-MA128 not only
Phenergan contains the medicine promethazine, and is used to treat a wide range of symptoms ranging from combat allergic symptoms to being used as a sleep aid. Predator Nutrition
Quercetin is a naturally occuring flavonoid. Quercetin has antioxidant, antiviral and anti-allergy effects. The antioxidant effect is attributed to the cathechol-B-ring and the location of the hydroxyl substitutions. Quercetin has demonstrated activity against some viruses. This is attributed to quercetins ability to reduce the infectivity of viruses and blocking viral replication. Quercetin has also been shown to have a positive effect on the human immune system. Possibly by increasing neutrophil chemotaxis, macrophage phagocytosis, natural killer cell lytic activity, and mitogen-stimulated lymphocyte proliferation. Quercetin has also been shown to have anti-allergy effects attributed to the fact that it may affect mast cell proliferation and secretory granule development.. ...
Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. Each volume presents insightful updates on pharmaceutical research and development for clinical researchers and healthcare professionals involved in obesity treatment programs.. The fourth volume of this series covers 6 reviews on anti-obesity treatment strategies including updates on obesity and cancer ...
Oxatomide IUPAC nomenclature 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-1,3-dihydro-2H-benzimidazol-2-one Classification H1-receptor antihistamine Piperazine antihistamine Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 426.6 g/mol 2 Physical appearance N/A 3 Melting point 153.6oC 4 Solubility N/A 5 Octanol/water partition coefficient N/A 5 […]. ...
NaturalNews) Spirulina is considered one of natures most perfect foods because it performs such a broad spectrum of activities in the body. Its nutritional profile shows it can replace many more expensive supplements, and its research profile reveals its dedication to promoting good health. Several animal studies have documented the ability of spirulina to arrest the development of cancer progression, reduce risk of cancer initiation, and boost the immune system. Spirulina has anti-viral and anti-allergic effects, and is a natural antihistamine. Recently, spirulina has been found effective at lowering the immune response when it has become overactive, a function that may make it effective against autoimmune diseases such as multiple sclerosis.. Spirulinas credentials date back more than three billion years. Spirulina are microscopic coiled blue-green algae that have been around for the past 3.6 billion years or so. Spirulina and other blue-green algae were the generators of the oxygen found in ...
Prednisolone is a hormone drug which provides an action to most functions of the body. It shows an anti-inflammatory, and anti-allergic action. Buy Prednisolone online.
Bacopa is a great tranquilizing, memory and learning enhancing, cerebral activator, anti-ulcer, neurotonic, immuno-modulator, adaptogen,antispasmodic, anti-asthmatic ayurvedic herb. Other benefits are anti-allergic action, and free radicals scavenging effect as herbal supplement in Epilepsy, anxiety and depression. Know its beneficial actions on brain, learning skills, anxiety, depression, stress, epileps memory, mental deficiency, Alzheimers disease,and ADHD children. http://www.holistic-herbalist.com/bacopa.html ...
What is Cortisol?. Cortisol is a steroid and a stress hormone. Production of cortisol is stimulated when stress is triggered. Cortisol plays an important role in the different metabolic processes in the body. Through its increased distribution in stress situations, it is able to provide energy by consuming sugar, fat and protein reserves. By immune processes cortisol also helps with its anti-inflammatory and anti-allergic effect, and has an important function in maintaining the health of the body.. Excessively low cortisol levels. It is well known that chronic stress is unhealthy - and stress is in turn the most important impulse that causes the increase of the distribution of cortisol. If the cortisol levels are too high, symptoms can include immunodeficiencies, depression, physical exhaustion, metabolic disorders, diabetes, obesity and sleeping disorders. Excessively high cortisol levels can indeed cause unpleasant symptoms.. Just the same, excessively low cortisol levels can interfere with ...
The risk of hyponatremia is not particularly high. Beware more of dehydration than hyponatremia. Nevertheless, you should not drink constantly. Its a good idea to have a drink at the pace of the drink points on the marathon route.. If a beginner runs the marathon very slowly, there is less heat in the body and less fluid is consumed. If you always drink a couple of cups at resting places and then drink some extra of your own drinks just in case, you may have too much fluid load.. When sweating on a hot day, also non-fitness enthusiasts should take care of hydration properly. And beware, you need to be careful with alcohol, as it drains your body.. Excess weight and several drugs may increase the symptoms of heat. These include, for example, anti-allergic drugs, beta-blockers, antidotes, and de-icing agents. Avoid taking any drugs like aspirin, ibuprofen and naproxen (NSAIDS) before or during a race if at all possible. These drugs increase the risk for exercise-associated hyponatremia and acute ...
Alan G. Kabat, OD, discusses why olopatadine 0.2% is his preferred anti-allergy medication for managing mild-to-moderate seasonal allergic conjunctivitis.
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Consultant Immunologist at Epsom and St Helier, Dr Grant Hayman said: The symptoms of hay fever can be unpleasant, but are quite common. There are a number of things you can do to help lessen the symptoms, such as wearing wraparound glasses to keep pollen out of your eyes, drying bed linen indoors during the pollen season and keeping the windows closed if at all possible.. If you are feeling very uncomfortable then I would recommend speaking to your pharmacist. They can give advice and suggest the best treatments, like antihistamine tablets, anti-allergy eye drops and/or steroid nasal sprays. If your symptoms get worse or do not get better after taking medication from your local pharmacist, get in touch with your GP.. For hay fever sufferers who also have asthma, the symptoms can be more severe and can often lead to tightness in the chest, shortness of breath and wheezing and coughing. If you have asthma, make sure you carry your reliever inhaler and know what to do if your symptoms get ...
Antiallergic medications are used to inhibit hypersensitivity in the allergy-predisposed individuals. They are blocking histamine receptors, responsible for allergic response development.
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M-Brace Vega Aligner Patella Stabilizer is designed to stabilize the motion of the knee joint, keeping it aligned during flexion and extension movements. Constructed entirely from breathable materials, the next-to-skin layer is made from anti-bacterial and anti-allergy fabric. Its complex structure, equipped with patella stabilizer, offers comfortable containment of the patellar compartment ...
Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: R1 is hydrogen, C1-6 alkyl or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydroxy, nitro, cyano, C2-10 acyloxy, NR6 R7 wherein R6 and R7 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl; or COR8 wherein R8 is hydroxy, C1-6 alkoxy or NR9 R10 wherein R9 and R10 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen, halogen, CF3, C1-4 alkoxy, C1-4 alkyl or any of the groups listed for R3 ; and R5 is hydrogen, C1-4 alkyl or benzyl optionally substituted in the phenyl ring by halogen, CF3, C1-4 alkoxy or C1-4 alkyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory and/or anti-allergy activity, and their use as pharmaceuticals.
As an active athlete, I had breathing problems, i.e. inadequate nasal airflow, on exercise in particular. This in turn led to frequent and deliberate blowing my nose and headache; I had a feeling of reduced airflow. I tried all the nasal hygiene products available and anti-allergy treatments, without success. The more so, my condition worsened from year to year. Then I visited Klapan Polyclinic at mid-August 2009 and was operated on within 2 weeks. I am very grateful to Professor Klapan and his surgical team, nurses in particular, for all their kindness, cordiality and assistance. The best of all, however, is the feeling that now, after the surgery, all my problems have vanished and I can normally breathe on both nostrils. The difference is most pronounced during my high-exercise trainings, when my nose works even better. In a word, the service offered to me by Klapan Polyclinic has substantially changed my life and I thank them all from the bottom of my heart, bless them!. R. I., pupil, born ...
It shut out pollen and the fine particles of the exhaust gas and is effective in an anti-allergy measure.. * There is not it in the genuine disposable item, and recycling is possible. ...
A selected ion monitoring method for the estimation of an anti-allergy compound isamaxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable analogue containing nine deuterium atoms
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Ciclesonide is a corticosteroid. It prevents the release of substances in the body that cause inflammation. Ciclesonide is used to prevent asthma attacks in adults and children who are at least 12 years. Ciclesonide may also be used for purposes not listed in this medication guide.
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment ...
Local treatment of antiseptic and anti-allergic rhinitis NASAL WAY Adult: 1 spray in each nostril 4 to 6 times a day. Child: 1 spray in each nostril 2 to 3 times a day. Infant: 1. Spraying in each nostril 1 to 2 times a day. The nasal sprays are done with the bottle in a vertical position.
Ceasing exposure to known allergens is the first step in anti-allergic treatment. Disposing of the allergen isnt constantly conceivable, as on account of dust sensitivities. Pharmaceuticals Different medications can alleviate the symptoms of rhinitis. Some are taken orally, others are nasal showers or eye drops (eye drops). On the off chance that over-the-counter items dont […]. ...
Ze Xie is also known as Alisma. The sweet, bland and cold herb has been used in TCM as anti-pyretic , as anti-bacterial, hypoglycemic, hypotensive, anti tumor, anti-allergic, etc., as it eliminates water, clear Heat, diuretic, etc., by enchaining the functions of bladder and kidney channels. Ingredients 1. Alisol A、B、C 2. Alosol A monoacetate 3. …. ...
It was my first on-line order! I always scared to lost money, to receive bad-quality product or that my parcel will be lost by post. But everything was good! My parcel arrived in selected day, in perfect condition, in professional package and I am using my anti-allergic pills already 3 weeks and result is great, so quality of medicine is also good. All that remains - to say thank you ...
It was my first on-line order! I always scared to lost money, to receive bad-quality product or that my parcel will be lost by post. But everything was good! My parcel arrived in selected day, in perfect condition, in professional package and I am using my anti-allergic pills already 3 weeks and result is great, so quality of medicine is also good. All that remains - to say thank you ...
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Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... The drug should not be used in children under two,[8] people with kidney disease,[8] or people who are allergic to aspirin.[8] ... Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] ... allergic and fibrotic lung reactions, lupus erythematosus-like reactions and rash (including urticaria), drug fever, ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... It is relatively toxic to humans, and many people have allergic reactions to it.[4] See: Hypersensitivity. Physicians sometimes ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... allergic disorders, ulcerative colitis and Crohn's disease, granulomatosis with polyangiitis, adrenocortical insufficiency, ... "Antineoplastic Agents, Hormonal". Medical Subject Headings. U.S. National Library of Medicine. 2009. Retrieved 11 November 2010 ... Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties.[32][33] Prednisone is ...
antiallergic agents, excluding corticosteroids *Cromoglicic acid. *aminosalicylic acid and similar agents *Sulfasalazine ... Common side effects include pain in the area of injection and allergic reactions.[3] Occasionally, hearing loss, low blood ... "Antimicrob Agents Chemother. 34 (6): 1227-31. doi:10.1128/AAC.34.6.1227. PMC 171789 . PMID 2393284.. ... "Antimicrob Agents Chemother. 23 (1): 138-41. doi:10.1128/AAC.23.1.138. PMC 184631 . PMID 6219616.. ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... Allergic reactions may occur.[1] It is unclear if medical use during pregnancy or breastfeeding is safe.[1] It is in the ... along with an anticaking agent such as cellulose) sprinkled on or mixed into the product. While not currently approved for use ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... and severe allergic reactions.[1] Long-term use of the pill form may cause adrenal insufficiency.[4] The pills may also cause ... I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer ... The activated glucocorticoid receptor-glucocorticoid complex up-regulates the expression of anti-inflammatory proteins in the ...
Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07). Rehydration. *Oral rehydration therapy ... The drug should not be used in children under two, people with kidney disease, or people who are allergic to aspirin.[4] ... Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is an aminosalicylate anti-inflammatory drug[2] used to ... allergic and fibrotic lung reactions, lupus erythematosus-like reactions and rash (including urticaria), drug fever, ...
Nelson, Wendel L. (2002). "Antihistamines and related antiallergic and antiulcer agents". In Williams, David H.; Foye, William ... Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies.[1] This includes allergic ... Common side effects include sleepiness, dry mouth, and headache.[1] Serious side effects are rare and include allergic ... Loratadine is indicated for the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticaria (hives), chronic ...
The drug is an anti-inflammatory,[8] antiallergic[9] immunomodulator.[10] Its mechanism of action is not well-determined, but ... In Japan, it is used to treat bronchial asthma, allergic rhinitis and conjunctivitis.[8] ... Nohara, A.; Ishiguro, T.; Ukawa, K.; Sugihara, H.; Maki, Y.; Sanno, Y. (1985). "Studies on Antianaphylactic Agents. 7. ... Amlexanox (trade name Aphthasol) is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers ( ...
Nelson, Wendel L. (2007). "Antihistamines and Related Antiallergic and Antiulcer Agents". In William O. Foye; Thomas L. Lemke; ... These indications may include: Allergic rhinitis Allergic conjunctivitis Allergic dermatological conditions (contact dermatitis ... helping to relieve allergic reactions. Agents where the main therapeutic effect is mediated by negative modulation of histamine ... These agents also commonly have action at α-adrenergic receptors and/or 5-HT receptors. This lack of receptor selectivity is ...
Nelson WL (2002). "Antihistamines and related antiallergic and antiulcer agents". In Williams DH, Foye WO, Lemke TL (eds.). ... For allergic rhinitis, loratadine is indicated for both nasal and eye symptoms - sneezing, runny nose, and itchy or burning ... This includes allergic rhinitis (hay fever) and hives. It is also available in combination with pseudoephedrine, a decongestant ... Serious side effects are rare and include allergic reactions, seizures, and liver problems. Use during pregnancy appears to be ...
Anti-allergic properties of pipethiaden--a new preventive agent for migraine]". Ceskoslovenska Farmacie (in Czech). 38 (6): 264 ...
"Anti-allergic properties of pirquinozol (SQ 13,847) an orally effective agent. Evaluation in an anti-IgE-induced pulmonary ... Free CA, Hall LE (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. II. Activity in vitro". The ... Casey FB, Abboa-Offei BE, Marretta J (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. I. Activity ... Pirquinozol (SQ-13,847) is a drug which was investigated as an antiallergen and antiasthmatic agent in the early 1980s but was ...
This causes the compound to have anti-allergic properties. The condensation of 6-acetyl-7-hydroxy-1,2,3,4-tetrahydronaphthalene ... Furukawa, Clifton T. (1984). "Other pharmacologic agents that may affect bronchial hyperreactivity". Journal of Allergy and ... It suppresses allergic reactions by binding to FcεRI receptor in mast cells, thereby inhibiting production of histamines. It is ... Allergic reactions or responses to inflammation or invading microorganisms are coordinated by these cells in a process called ...
... is rich in lactic acid bacteria and of excellent anti-allergic potential.[54][55] ... but it is difficult to make soy sauce without using some quantity of salt as an antimicrobial agent.[57] ... Kobayashi, Makio (18 April 2005). "Immunological Functions of Soy Sauce: Hypoallergenicity and Antiallergic Activity of Soy ...
Chang TW, Wu PC, Hsu CL, Hung AF, 2007, "Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases." Advances in ... Chang TW and Shiung YY, 2006, "Anti-IgE as a mast cell-stabilizing therapeutic agent." The Journal of Allergy and Clinical ... Chang is a cofounder of Tanox, a biopharmaceutical company specialized in anti-IgE therapies for the treatment of allergic ... antibodies that target the IgE-mediated allergic pathway have proven effective in the treatment of various allergic diseases. ...
... in mice suggest that Gleditsia sinensis ethanolic extract could be an effective therapeutic agent for the treatment of allergic ... Li W.-H., Zhang X.-M., Tian R.-R., Zheng Y.-T., Zhao W.-M., Qiu M.-H. (2007). "A new anti-HIV lupane acid from Gleditsia ... A lupane acid extracted from the thorns showed in vitro anti-HIV activity. The fruit extract of Gleditsia sinensis also has ... G. sinensis has in vitro effects that may be indicative of antiallergic activities, possibly due to the saponins in fruits. ...
Kakiuchi M, Ohashi T, Musoh K, Kawamura K, Morikawa K, Kato H (1997). "Studies on the novel antiallergic agent HSR-609: its ... O]ral ketotifen has been used in patients with asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, chronic ... In its ophthalmic form, it is used to treat allergic conjunctivitis. In its oral form, it is used to prevent asthma attacks or ... Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor. "[ ...
Unpasteurized soy sauce is rich in lactic acid bacteria and of excellent anti-allergic potential. Soy sauce does not contain ... but it is difficult to make soy sauce without using some quantity of salt as an antimicrobial agent. A serving of 100 ... Kobayashi, Makio (18 April 2005). "Immunological Functions of Soy Sauce: Hypoallergenicity and Antiallergic Activity of Soy ...
Loperamide (Imodium AD) an anti-diarrheal agent. Pepto Bismol tablets, to settle upset stomachs, treat diarrhea, and heartburn ... Epi-pen, epinephrine in an auto injecting "pen" to counter anaphylactic (severe allergic) reactions. A combat medic is ... Hemostatic agents, such as Celox, Hemcon bandages, and others. Some hemostatic agents are controversial due to their ... acetaminophen (Tylenol), anti-pyretic and pain reducer. Naproxen and ibuprofen, different NSAIDs which reduce pain and ...
They are the most common prescribed class of topical anti allergy agent. Olopatadine (Patanol, Pazeo) and ketotifen fumarate ( ... The cause of allergic conjunctivitis is an allergic reaction of the body's immune system to an allergen. Allergic ... Both seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) are two acute allergic conjunctival ... Treatment consists of antihistamine, mast cell stabilizers, dual mechanism anti-allergen agents, or topical antihistamines. ...
... have also been suggested as causative agents. However, the literature is scare and conflicting as passive infusion of anti-IgA ... The usual cause of these allergic reactions is proteins in the donor plasma. These proteins are removed by the process of ... The most common reason for using washed red blood cells in transfusion medicine is to prevent the recurrence of severe allergic ... Hirayama F (February 2013). "Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests ...
... anti-cancer[citation needed] Allergic reactions to Taxol are most often allergic reactions to Kolliphor EL; symptoms include ... intravenous anaesthetic agent, originally presented in Kolliphor EL for trials; now presented in a lipid emulsion[citation ... The allergic reaction is usually immediate and is similar to severe allergic reactions of many other substances that trigger ... Miconazole, anti-fungal[citation needed] Docetaxel, anti-cancer[citation needed] Aci-Jel (acetic acid / oxyquinoline / ...
Antileukotrines are anti-inflammatory agents which function as leukotriene-related enzyme inhibitors (arachidonate 5- ... Dery, R.E.; Mathison, R.; Davison, J.; Befus; A.D. (2001). "Inhibition of allergic inflammation by C-terminal peptides of the ... More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... Many modern analgesics and anti-inflammatory agents (ex. paracetamol, and its previously used predecessor phenacetin) are ...
Yamatake Y, Sasagawa S, Yanaura S, Okamiya Y (1977). "Ipratropium Bromide (Sch1000) の抗アレルギー性喘息効果" [Antiallergic asthma effect ... Potentially serious side effects include urinary retention, worsening spasms of the airways, and a severe allergic reaction. It ... India, smoking the herb stramonium (an anticholinergic agent related to ipratropium and tiotropium currently used in inhalers) ... Interactions with other anticholinergics like tricyclic antidepressants, anti-Parkinson drugs and quinidine, which ...
Antiallergic agents,. excluding corticosteroids. *Spaglumic acid. *histamine antagonists (Levocabastine. *Antazoline. * ... Ciclesonide is a glucocorticoid used to treat asthma and allergic rhinitis. It is marketed under the brand names Alvesco for ...
Antiallergic agents,. excluding corticosteroids. *Spaglumic acid. *histamine antagonists (Levocabastine. *Antazoline. * ... Xylometazoline, also spelled xylomethazoline, is a medication which is used to improve symptoms of nasal congestion, allergic ...
9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3. Austin RJ, Maschera B, Walker A, ... People should not use mometasone topical (skin cream) if: hypersensitive or allergic to any ingredient in the skin cream ... It is believed that the action of corticosteroid anti-inflammatory agents is bound to inhibitive proteins of phospholipase A2, ... Mometasone furoate can be used with formoterol for the treatment of asthma, due to its anti-inflammatory properties. People ...
... is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm ... It was withdrawn in Europe and Australia because of allergic reactions. Ointments and lotions containing bufexamac are used for ... Bufexamac is thought to act by inhibiting the enzyme cyclooxygenase, which would make it a non-steroidal anti-inflammatory drug ...
Hormonal agents[edit]. In women, the use of combined birth control pills can improve acne.[100] These medications contain an ... Proposed mechanisms for tea tree oil's anti-acne effects include antibacterial action against C. acnes and anti-inflammatory ... which has been linked to rare cases of allergic reactions, including anaphylaxis and severe asthma exacerbations in susceptible ... "Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. PMC 6325184. PMID 30397052.. ...
Other agents causing ophthalmia neonatorum include Herpes simplex virus (HSV 2), Staphylococcus aureus, Streptococcus ...
"Anti-vaxxers stopped the last Lyme disease vaccine. The FDA has just fast-tracked a new one". Newsweek. 25 July 2017. Archived ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... because if the person is allergic, anaphylaxis could result.[142] Instead, a product should be sprayed on the tick to cause it ... generates antibodies against the OspA protein so a tick feeding on a vaccinated dog draws in blood full of anti-OspA antibodies ...
... also has neuroprotective properties in its demonstrated anti-hypoxia or anti-ischemia effects; there is a ... Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... moclobemide has been recommended as a first line agent for the treatment of depression in the elderly.[55] Due to the side ... it was then tested for anti-cholinergic properties to see if it was a possible antidepressant but these tests also proved ...
In the European Union it is indicated, in combination with other anti-retroviral medicinal products, for the treatment of Human ... Serious side effects included allergic reactions and abnormal liver function in patients who were also infected with hepatitis ... Severe side effects may include allergic reactions and liver problems.[5] There is tentative concerns that use during pregnancy ...
... long-acting agents are recommended.[2] Long-acting agents partly work by reducing hyperinflation.[74] If long-acting ... and most often is linked to an allergic reaction to a fungus contained in contaminated hay or straw.[213] COPD is also commonly ... and act as anti-inflammatories. They show promise in decreasing the rate of exacerbations, but do not appear to change a ... External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. ...
April 22, 1988 Anti-Acne Drug Faulted in Birth *^ CDC. January 21, 2000 Accutane®-Exposed Pregnancies -- California, 1999 MMWR ... Vasculitis (i.e. Granulomatosis with polyangiitis, allergic vasculitis). Respiratory, thoracic and mediastinal ...
This is known as fast-pacing, overdrive pacing, or anti-tachycardia pacing (ATP). ATP is only effective if the underlying ... Allergic reaction to the dye or anesthesia used during the procedure. Swelling, bruising or bleeding at the generator site, ... who have body hair on the chest may want to remove the hair by clipping just prior to surgery or using a depilatory agent ( ...
As it turns out, Lord Rees is an atheist, though one who said in a recent interview that he is "not allergic to religion," and ... I shall use the world Anti-Deism to signify the opinion that there does not exist a Creator who made and sustains the Universe ... remembered for his identification of the bacterium Mycobacterium leprae in 1873 as the causative agent of leprosy.[147][148] ... Planck was religious and had a firm belief in God; Bohr was not, but his objection to Planck's view had no anti-religious ...
... helps remove infectious agents.[2] Also, mucus traps infectious agents.[2] The gut flora can prevent the colonization of ... Finlay BB, McFadden G (February 2006). "Anti-immunology: evasion of the host immune system by bacterial and viral pathogens". ... serious allergic reactions that can cause death).[4] When activated, mast cells rapidly release characteristic granules, rich ... Acting as a physical and chemical barrier to infectious agents; via physical measures like skin or tree bark and chemical ...
"Respiratory and Allergic Health Effects of Dampness, Mold, and Dampness-Related Agents: A Review of the Epidemiologic Evidence ... Expert Rev Anti Infect Ther. 8 (8): 957-64. doi:10.1586/eri.10.72. PMID 20695750.. ... allergic alveolitis, chronic rhinosinusitis and allergic fungal sinusitis. Severe reactions are rare but possible. A person's ... Health problems associated with high levels of airborne mold spores include[18][unreliable medical source?] allergic reactions ...
Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma»։ The Cochrane ... Custovic A, Simpson, A (2012)։ «The role of inhalant allergens in allergic airways disease»։ Journal of Investigational ... 16,0 16,1 16,2 16,3 16,4 Scott J. P., Peters-Golden M. (September 2013)։ «Antileukotriene agents for the treatment of lung ... Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma»։ The Cochrane ...
"Antimicrobial Agents and Chemotherapy. 38 (8): 1864-67. doi:10.1128/aac.38.8.1864. PMC 284652. PMID 7986023.. ... The most dangerous adverse effect is a severe allergic reaction to either the virus material itself or residues from the hen ... Wilson JC, von Itzstein M (July 2003). "Recent strategies in the search for new anti-influenza therapies". Current Drug Targets ... The first influenza virus to be isolated was from poultry, when in 1901 the agent causing a disease called "fowl plague" was ...
For allergic disordersEdit. anti-allergics, antihistamines, NSAIDs, Corticosteroids For nutritionEdit. Tonics, electrolytes and ... In the inter-war period, the first anti-bacterial agents such as the sulpha antibiotics were developed. The Second World War ... These were drugs that worked chiefly as anti-anxiety agents and muscle relaxants. The first benzodiazepine was Librium. Three ... Anti-allergy: mast cell inhibitors. *Anti-glaucoma: adrenergic agonists, beta-blockers, carbonic anhydrase inhibitors/ ...
T. Shimizu u. a.: Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. In: ... 2005 Nov;26(5):343-56 (PMID 16323269); Erratum. In: Int J Antimicrob Agents. Feb 2006, Bd. 27, Nr. 2, S. 181. ... Brovko, T. E. (July-August 1970). „Two cases of allergic reaction after administration of propolis drugs". Zh Ushn Nos Gorl ... T. Shimizu et al.: Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. ...
Resistance to cefixime has reached a level such that it is no longer recommended as a first-line agent in the United States, ... It is also possible for an individual to have an allergic reaction to the bacteria, in which case any appearing symptoms will ... and gonococci and commensal Neisseria species can coexist for long time periods in the pharynx and share anti-microbial ...
... or the presence of IgA anti-TG2 and/or anti-endomysial intestinal deposits, might be specific markers for celiac disease. ... Delayed allergic reactions may occur with these type of tests, which have to be negative over time, but there are no ... Bressan, Paola; Kramer, Peter (2016). "Bread and Other Edible Agents of Mental Disease". Frontiers in Human Neuroscience. 10. ... If an allergic reaction can not be clearly identified, the diagnosis should be confirmed by food provocation tests, ideally ...
Their range of functions is wide and includes participation in allergic reactions, innate and adaptive immunity, inflammation, ... Neutrophils have three strategies for directly attacking micro-organisms: phagocytosis (ingestion), release of soluble anti- ... Antimicrobial agents (Defensins and Eosinophil cationic protein). *Enzymes *Acid hydrolases: further digest bacteria ... and allergic reactions, particularly anaphylaxis.[3] Mast cells are also involved in mediating inflammation and autoimmunity as ...
This is the case for modifications that do not confer an advantage to the animal or doesn't secrete any infectious agents. If a ... Analysis of the chemical composition of the relevant plant parts, measuring nutrients, anti-nutrients as well as any natural ... stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares ... has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.. ...
NSAID-induced non-allergic reactionsEdit. Aspirin and other non-steroidal anti-inflammatory drugs (NSAID) can cause NSAID- ... Alox5 and presumably human ALOX5 functions may vary widely depending on the agents stimulating their and types of metabolites ... These drugs are in common use as prophalaxis and chronic treatment of allergic and non-allergic asthma and rhinitis diseases[7] ... LTC4, LTD4, and LTE4 contribute to allergic airways reactions such as asthma, certain non-allergic hypersensitivity airways ...
"Anti-slavery: Today's fight for tomorrow's freedom. Archived from the original on 20 July 2014. Retrieved 16 July 2014.. ... A few studies have documented allergic reactions from chocolate in children.[80] Other research has shown that dark chocolate ... Usually, an emulsifying agent, such as soy lecithin, is added, though a few manufacturers prefer to exclude this ingredient for ... and anti-slavery[122] organisations are highlighting and campaigning against the use of trafficking in the chocolate industry. ...
Nonsteroidal anti-inflammatory drugs Unselective agents Aceclofenac. Comes in betadex salt and free acid forms; practically ... Mild-moderate postoperative pain; acute migraine; inflammation of the eye due to cataract surgery or allergic seasonal ... Psychotropic agents[edit]. Other psychotropic analgesic agents include ketamine (an NMDA receptor antagonist), clonidine and ... Main article: Nonsteroidal anti-inflammatory drug. Nonsteroidal anti-inflammatory drugs (usually abbreviated to NSAIDs), are a ...
The details of parasite immune modulation are not yet known, but may include secretion of anti-inflammatory agents or ... 2008). "Helminth Infection with Litomosoides sigmodontis Induces Regulatory T Cells and Inhibits Allergic Sensitization, Airway ... 2002) injected an anti-MHC Class II antibody into mice expressing a single type of MHC Class II molecule (H-2b) to temporarily ... Certain chemical agents and drugs can also be associated with the genesis of autoimmune conditions, or conditions that simulate ...
Examples in non-food crops include production of pharmaceutical agents,[47] biofuels,[48] and other industrially useful goods,[ ... has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.. ... stressed the absence of evidence that commercially available GM foods cause clinical allergic manifestations. The BMA shares ...
From the training course titled "Smallpox: Disease, Prevention, and Intervention" (www.bt.cdc.gov/agent/smallpox/training/ ... Durbach, Nadja (2005). Bodily Matters: The Anti-Vaccination Movement in England, 1853-1907. ISBN 978-0-8223-3423-1. .. ... including toxic or allergic reaction at the site of the vaccination (erythema multiforme), spread of the vaccinia virus to ... The British used smallpox as a biological warfare agent at the Siege of Fort Pitt during the French and Indian Wars (1754-1763 ...
Anti-microtubule agents[edit]. Vinca alkaloids prevent the assembly of microtubules, whereas taxanes prevent their disassembly ... Some medications can trigger allergic or pseudoallergic reactions.. Specific chemotherapeutic agents are associated with organ- ... Available agents[edit]. Main article: List of antineoplastic agents. There is an extensive list of antineoplastic agents. ... Alkylating agents[edit]. Main article: Alkylating antineoplastic agent. Alkylating agents are the oldest group of ...
... and is indicated in the emergency treatment of allergic reactions including anaphylaxis to stings, contrast agents, medicines ... World Anti-Doping Agency prohibited substances. *Peripherally selective drugs. *Respiratory therapy. Hidden categories: *CS1: ... "Part 6: Advanced Cardiovascular Life Support Section 6: Pharmacology II: Agents to Optimize Cardiac Output and Blood Pressure ... prolong the action of the anesthetic agent. Due to epinephrine's vasoconstricting abilities, the use of epinephrine in ...
Onions contain phenolics and flavonoids that have potential anti-inflammatory, anti-cholesterol, anticancer and antioxidant ... Onions are a staple in Indian cuisine, often used as a thickening agent for curries and gravies. Onions pickled in vinegar are ... Some people suffer from allergic reactions after handling onions.[5] Symptoms can include contact dermatitis, intense itching, ... anti-cholesterol, anticancer and antioxidant properties.[ต้องการแหล่งอ้างอิงทางการแพ

No data available that match "anti allergic agents"


  • Allergic rhinitis is an inflammatory disease characterized by nasal wall remodeling with intense infiltration of eosinophils and mast cells/basophils. (hindawi.com)
  • Nasal fibroblasts (NF) were established from nasal polyp tissues taken from patients with allergic rhinitis. (hindawi.com)
  • The present data suggest that the attenuating effect of TR on MMP-2 and MMP-9 production from NF induced by inflammatory stimulation may underlie the therapeutic mode of action of the agent in patients with allergic diseases, including allergic rhinitis. (hindawi.com)
  • Allergic diseases such as bronchial asthma, various allergic rhinitis and Japanese cedar (Sugi) pollinosis are caused by the action of a substance released from mastocytes as a result of an allergic reaction, such as histamine on the bronchus, the nasal mucosa or the like and develop a variety of symptoms. (google.com)
  • As a nasal spray, used for the treatment and management of seasonal allergic rhinitis. (pharmacycode.com)
  • Allergic rhinitis (AR) and asthma are inflammatory conditions of the airways that often occur concomitantly. (nih.gov)
  • The first three patients with a confirmed diagnosis of AR (Allergic Rhinitis and its Impact on Asthma classification) were asked to complete the Juniper Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). (nih.gov)
  • Allergic rhinitis was mild for 54% and moderate/severe for 46% of patients. (nih.gov)
  • An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions. (ebi.ac.uk)
  • This study supports the regular use of nasal irrigation with a positive-pressure as an effective adjunctive treatment for allergic rhinitis. (greenmedinfo.com)
  • Pfizer Inc and UCB Pharma today announced the approval of a new chewable formulation of Zyrtec® (cetirizine HCl) for the treatment of seasonal and perennial allergic rhinitis (inflammation of the nasal passages) and chronic idiopathic urticaria (itching and hives of unknown causes) in children aged two years and older. (news-medical.net)
  • Local hypersensitivity reactions at mucosal surfaces play an important role in the pathophysiology of allergic diseases, including food allergy, atopic asthma, and rhinitis. (jimmunol.org)
  • This group comprises preparations for local treatment in nasal congestion (e.g. sympathomimetics) or for prophylaxis and treatment of allergic rhinitis (e.g. corticosteroids, cromoglicate preparations). (whocc.no)
  • These indications may include: Allergic rhinitis Allergic conjunctivitis Allergic dermatological conditions (contact dermatitis) Rhinorrhea (Runny nose) Urticaria Angioedema Diarrhea Pruritus (atopic dermatitis, insect bites) Anaphylactic or anaphylactoid reactions-adjunct only Nausea and vomiting Sedation (first-generation H1-antihistamines) H1-antihistamines can be administered topically (through the skin, nose, or eyes) or systemically, based on the nature of the allergic condition. (wikipedia.org)
  • This medication is an antihistamine, prescribed for allergic conjunctivitis. (medindia.net)
  • As an ophthalmic it is used for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. (pharmacycode.com)
  • It is used as a topical agent for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis and iritis. (pharmacycode.com)
  • Used to treat allergic conjunctivitis (itching eyes), olopatadine inhibits the release of histamine from mast cells. (drugbank.ca)
  • For the treatment of ocular itching associated with allergic conjunctivitis. (drugbank.ca)
  • The frequency of IL-4-producing conjunctival T cells in patients with vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (VKC) were significantly higher than that in patients with allergic conjunctivitis (AC). (nii.ac.jp)
  • Tear levels of cytokines, interleukin-2(IL-2), interferon gamma (IFN-γ), IL-4, IL-5, IL-6, IL-8 and IL-13, in 49 patients with ACD (allergic conjunctivitis 14 cases, atopic keratoconjunctivitis 14 cases and vernal keratoconjunctivitis 21 cases) were measured with ELISA (enzyme-linked immunosorbent assay) method. (nii.ac.jp)
  • Antazoline is a 1st generation antihistamine that also anticholinergic properties used to relieve nasal congestion and in eye drops , usually in combination with naphazoline , to relieve the symptoms of allergic conjunctivitis . (wikidoc.org)
  • Background Tranilast is an anti-allergic agent known to inhibit the release of histamine, interleukin-1β, transforming growth factor β1, and platelet-derived growth factor from various cells and currently is used to treat allergic diseases, keloids, and hypertrophic scars. (fujita-hu.ac.jp)
  • Azelastine, a phthalazinone derivative, selectively blocks H 1 -receptors on effector cells, inhibiting the release of histamine involved in allergic response. (mims.com)
  • It is used for symptomatic relief of symptoms caused by the release of histamine in allergic reactions. (medscape.com)
  • Perper, RJ, Oronsky, AL & Blancuzzi, V 1974, ' Specificity of 48 hour passive cutaneous anaphylaxis reactions (PAC) in rats and mice for the analysis of antiallergic agents ', The Journal of Allergy and Clinical Immunology , vol. 53, no. 2, pp. 66. (elsevier.com)
  • A drug used to treat allergic reactions. (ebi.ac.uk)
  • Chemotherapeutic agents may induce hypersensitivity reactions in pediatric patients. (greenmedinfo.com)
  • This medicine reduces allergic reactions. (uhhospitals.org)
  • Topical triamcinolone (0.1% cream) is an anti-inflammatory that is administered for intense, localized allergic reactions. (medscape.com)
  • Antihistamines are used to treat minor allergic reactions and anaphylaxis. (medscape.com)
  • Chlorpheniramine is used to treat intense, localized allergic reactions. (medscape.com)
  • H1 antagonists, also called H1 blockers, are a class of medications that block the action of histamine at the H1 receptor, helping to relieve allergic reactions. (wikipedia.org)
  • Multiple studies have shown that H1 antihistamines, including fexohexadine, interfere with exercise induced muscle growth and repair In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface IgE antibodies on mast cells and basophils. (wikipedia.org)
  • Patient response and occurrence of adverse drug reactions vary greatly between classes and between agents within classes. (wikipedia.org)
  • This medication is an anti-allergic and anti-inflammatory agent, prescribed for aphthous ulcers or canker sores in people with normal immune systems. (medindia.net)
  • The clinical importance of eosinophils in asthma has been shown by the observation of frequent exacerbation in patients with high sputum eosinophil counts and a corresponding decrease in exacerbations when anti-inflammatory therapy was adjusted to maintain low sputum eosinophil percentages. (nih.gov)
  • [2] Mesalazine is an aminosalicylate and anti-inflammatory . (wikipedia.org)
  • Their anti-allergic and anti-inflammatory activities were evaluated. (bvsalud.org)
  • Mast cells mediate early neutrophil recruitment and exhibit anti-inflammatory properties via the formyl peptide receptor 2/lipoxin A receptor. (bireme.br)
  • BACKGROUND AND PURPOSE: In recent years, studies have focused on the resolution of inflammation, which can be achieved by endogenous anti-inflammatory agonists such as Annexin A1 (AnxA1). (bireme.br)
  • MC recruitment of neutrophils could be blocked by preventing the pro-inflammatory activation (using cromolyn sodium) or enhancing an anti-inflammatory phenotype (using Ac2-26) in MCs. (bireme.br)
  • therefore, the main thrust of asthma therapy is to limit exposure to triggering factors and to reduce the inflammatory process using anti-inflammatory agents. (cmaj.ca)
  • it may also decrease after anti-inflammatory therapy and with age, especially in children. (cmaj.ca)
  • Reishi's anti-inflammatory benefits are thought to be partly due to its powerful antioxidant action. (positivehealth.com)
  • These results suggest that IL-4-producing T cells that have infiltrated into the conjunctiva play an important role in the immunopathogenesis of allergic conjunctival diseases, and P-selectin ligand is involved in the entry of T cells into allergic inflammatory site and correlation between tear cytokines show various patterns suggesting the complexity and redundancy of cytokines. (nii.ac.jp)
  • Anti-inflammatory medicines. (uhhospitals.org)
  • Inhaled medicines may be anti-inflammatory or bronchodilating. (uhhospitals.org)
  • Corticosteroids have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)
  • This agent can be used to treat inflammatory dermatosis that is responsive to steroids. (medscape.com)
  • Nedocromil is a anti-inflammatory agent and can be administered directly to the bronchial mucosa. (drugbank.ca)
  • Numerous antihistamic agents have heretofore been known as therapeutic agents for such allergic diseases, namely, antiallergic agents. (google.com)
  • High intestinal IgA in early life associates with minimal intestinal inflammation and indicates reduced risk for IgE-associated allergic diseases. (greenmedinfo.com)
  • Further, increased frequency of P-selectin ligand expressing IL-4-producing T cells was observed in conjunctiva compared to that in PBMC of the patients with allergic conjunctival diseases. (nii.ac.jp)
  • These mediators are responsible for the symptoms in allergic conditions such as allergic asthma. (frontiersin.org)
  • Released mast cell chemicals such as histamine, serotonin, proteases, and lipid mediators produce alterations in epithelial and smooth muscle physiology ( 1 ) that are responsible for many of the acute symptoms of allergic disease. (jimmunol.org)
  • They are effective in the relief of allergic symptoms, but are typically moderately to highly potent muscarinic acetylcholine receptor (anticholinergic) antagonists as well. (wikipedia.org)
  • Tranilast (N-[3,4-dimethoxycinnamolyl]anthranilic acid) is an anti-allergic drug that inhibits release of the chemical mediators from mast cells and it used for the treatment of keloids and hypertrophic scars by its inhibition of growth-promoting transforming growth factor (TGF)-β 1 from fibroblasts. (go.jp)
  • Belongs to the class of topical antiallergic preparations, excluding corticosteroids. (mims.com)
  • Adlay bran extract can reduce an allergic reaction by balancing Th1/Th2 immune responses. (greenmedinfo.com)
  • David continues to take Reishi and can now stroke cats without suffering an allergic reaction. (positivehealth.com)
  • David may well have been in situations that would have caused an allergic reaction before this incident without being aware that his immune response had changed. (positivehealth.com)
  • Many pharmaceutical agents including ophthalmic eyedrops and systemic drugs prescribed by general practitioners and various specialists (in psychiatry, otorhinolaryngology, ophthalmology, medicine, and anaesthesia) can precipitate an acute angle closure attack. (hkmj.org)
  • The medications include: anti-histamines, anti-epileptics, antiparkinsonian agents, antispasmolytic drugs, mydriatic agents, sympathetic agents, and botulinum toxin.Since acute angle closure attack is a potentially blinding eye disease, it is extremely important to be vigilant and aware of ophthalmic and systemic medications that can lead to such attacks in predisposed subjects and to diagnose the condition when it occurs. (hkmj.org)
  • This agent competes with histamine or H1-receptor sites on effector cells in blood vessels and the respiratory tract. (medscape.com)
  • Product categories of Anti-Allergic Agents , we are specialized manufacturers from China, Anti-Allergic Agents , Chlorphenamine Tablets 4Mg suppliers/factory, wholesale high-quality products of Anti-Allergic Agents R & D and manufacturing, we have the perfect after-sales service and technical support. (nouvasant.com)
  • Oxatomide], which contains piperzine moiety, its anti-allergic effects possess antagonist activities against chemical mediators such as histamine , serotonine and leukotrienes [which cause allergy ]. (bvsalud.org)
  • Prescription of anti-asthma treatments significantly increased with the severity of AR. (nih.gov)
  • When patients with life-threatening bacterial infections are allergic to antibiotics, drug desensitization may be an option when no other alternative exists according to a report published this month in Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI). (news-medical.net)
  • Among these, azatadine, ketotifen, promethazine and the like are known as tricyclic antihistamic agents. (google.com)
  • Thus, tranilast can be a potent therapeutic agent to inhibit the growth of neurofibromas. (go.jp)
  • If you want to know more about the products in Anti-Allergic Agents, please click the product details to view parameters, models, pictures, prices and other information about Anti-Allergic Agents,Chlorphenamine Tablets 4Mg. (nouvasant.com)
  • In the meantime, loratadine was developed as an antihistamic agent of tricyclic system reduced in sedative action. (google.com)
  • Cite this: Allergic Contact Dermatitis: Topical Preservatives, Part I - Medscape - Mar 01, 2010. (medscape.com)
  • Cyclic nucleotide phosphodiesterase inhibition required much higher concentrations (IC 50 ∼10 −3 M ). It is suggested that some of the anti-allergic actions of theophylline (clinical concentration range: 10 −5 -10 −4 M ) does not involve cyclic nucleotides but may be due to inhibition of the effects of endogenous adenosine. (springer.com)
  • In normal release, cortisol (like other glucocorticoid agents) has widespread actions which help restore homeostasis after stress . (thefullwiki.org)
  • Over the past 30 years, much effort has been directed at developing anticancer agents that can interfere with EGFR activity, such as, monoclonal antibodies and small-molecule inhibitors. (mdpi.com)
  • Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also described. (google.com)
  • This invention relates to novel benzo[5,6]cyclohepta[1,2-b]pyridine derivatives or salts thereof and also to antiallergic agents containing same and having excellent antihistamic action and reduced central action. (google.com)
  • Mast cells are responsible for the majority of allergic conditions. (frontiersin.org)
  • This medication is a non-sedating antihistamine, prescribed for allergic conditions. (medindia.net)
  • Topical medications and anti-arrhythmic and anticonvulsive agents. (medscape.com)
  • These agents also commonly have action at α-adrenergic receptors and/or 5-HT receptors. (wikipedia.org)
  • The drug should not be used in children under two, [8] people with kidney disease , [8] or people who are allergic to aspirin . (wikipedia.org)
  • Antiretroviral regimens are complex, have serious side effects, pose difficulty with adherence, and carry serious potential consequences from the development of viral resistance because of nonadherence to the drug regimen or suboptimal levels of antiretroviral agents. (cdc.gov)
  • other agents may have antihistaminergic action but are not true antihistamines. (wikipedia.org)
  • H1-antihistamines are clinically used in the treatment of histamine-mediated allergic conditions. (wikipedia.org)
  • The newer, second-generation H1-antihistamines are far more selective for peripheral histamine H1-receptors and have a better tolerability profile compared to the first-generation agents. (wikipedia.org)
  • This lack of receptor selectivity is the basis of the poor tolerability profile of some of these agents, especially when compared with the second-generation H1-antihistamines. (wikipedia.org)
  • Agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage. (nih.gov)