Tropaeolaceae: A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.Molecular Conformation: The characteristic three-dimensional shape of a molecule.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.GuanineHeterocyclic Compounds, Bridged-Ring: A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Base Pairing: Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.Pachyrhizus: A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).Deoxyguanosine: A nucleoside consisting of the base guanine and the sugar deoxyribose.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Deoxycytosine Nucleotides: Cytosine nucleotides which contain deoxyribose as the sugar moiety.Guanosine: A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).G-Quadruplexes: Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Oligodeoxyribonucleotides: A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.IndiaDeoxyadenine Nucleotides: Adenine nucleotides which contain deoxyribose as the sugar moiety.Inosine: A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.Adenine: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.Crystallography, X-Ray: The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Sulfolobus solfataricus: A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Plants, Medicinal: Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Base Composition: The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Deoxyadenosines: Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.Nucleosides: Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Hepatitis C Antibodies: Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Isomerism: The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Oxytocics: Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Protons: Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.DNA Polymerase beta: A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC 2.7.7.7.Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Dinucleoside Phosphates: A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.PhotochemistryOligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Bacteriorhodopsins: Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.Glycosides: Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)Molecular Mimicry: The structure of one molecule that imitates or simulates the structure of a different molecule.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.Kinetics: The rate dynamics in chemical or physical systems.Spectrum Analysis, Raman: Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.Thermodynamics: A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Hepatitis B: INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.Nucleotides: The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Adenosine: A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Mice, Inbred BALB CAnti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Cell Line, Tumor: A cell line derived from cultured tumor cells.Circular Dichroism: A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Hepatitis B Surface Antigens: Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.Antitubercular Agents: Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Blood DonorsBlotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.IranImmunoglobulin A: Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Antigen-Antibody Reactions: The processes triggered by interactions of ANTIBODIES with their ANTIGENS.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)DNA-Directed DNA Polymerase: DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Radioimmunoassay: Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Spleen: An encapsulated lymphatic organ through which venous blood filters.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Catalytic Domain: The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Immunotherapy: Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.Helicobacter Infections: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Chromatography, Affinity: A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Hepacivirus: A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.Mice, Inbred C57BLAntigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Helicobacter pylori: A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Molecular Weight: The sum of the weight of all the atoms in a molecule.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast. (1/477)

BACKGROUND: Inflammatory and immunological responses of vascular cells have been shown to play a significant role in the progression of atheromatous formation. Tranilast [N-(3,4-dimethoxycinnamoyl) anthranillic acid] inhibits release of cytokines and chemical mediators from various cells, including macrophages, leading to suppression of inflammatory and immunological responses. This study tested whether tranilast may suppress atheromatous formation in Watanabe heritable hyperlipidemic (WHHL) rabbits. METHODS AND RESULTS: WHHL rabbits (2 months old) were given either 300 mg x kg-1 x d-1 of tranilast (Tranilast, n=12) or vehicle (Control, n=13) PO for 6 months. Tranilast treatment was found to suppress the aortic area covered with plaque. Immunohistochemical analysis showed that there was no difference in the percentage of the RAM11-positive macrophage area and the frequency of CD5-positive cells (T cells) in intimal plaques between Tranilast and Control. Major histocompatibility complex (MHC) class II expression in macrophages and interleukin-2 (IL-2) receptor expression in T cells, as markers of the immunological activation in these cells, was suppressed in atheromatous plaque by tranilast treatment. Flow cytometry analysis of isolated human and rabbit peripheral blood mononuclear cells showed that an increase in expression both of MHC class II antigen on monocytes by incubation with interferon-gamma and of IL-2 receptor on T cells by IL-2 was suppressed by the combined incubation with tranilast. CONCLUSIONS: The results indicate that tranilast suppresses atherosclerotic development partly through direct inhibition of immunological activation of monocytes/macrophages and T cells in the atheromatous plaque.  (+info)

Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery. (2/477)

BACKGROUND: Activation of vascular chymase plays a major role in myointimal hypertrophy after vascular injury by augmenting the production of angiotensin (ANG) II. Because chymase is synthesized mainly in mast cells, we assumed that the chymase-dependent ANG II formation could be downregulated by tranilast, a mast cell-stabilizing antiallergic agent. We have assessed inhibitory effects of tranilast on neointima formation after balloon injury in the carotid artery of dogs, which share a similar ANG II-forming chymase with humans, and further explored the pathophysiological significance of vascular chymase. METHODS AND RESULTS: Either tranilast (50 mg/kg BID) or vehicle was orally administered to beagles for 2 weeks before and 4 weeks after balloon injury. Four weeks after the injury, remarkable neointima was formed in the carotid arteries of vehicle-treated dogs. Chymase mRNA levels and chymaselike activity of vehicle-treated injured arteries were increased 10.2- and 4.8-fold, respectively, those of uninjured arteries. Angiotensin-converting enzyme (ACE) activity was slightly increased in the injured arteries, whereas ACE mRNA levels were not. Tranilast treatment completely prevented the increase in chymaselike activity, reduced the chymase mRNA levels by 43%, and decreased the carotid intima/media ratio by 63%. In vehicle-treated injured arteries, mast cell count in the adventitia showed a great increase, which was completely prevented by the tranilast treatment. Vascular ACE activity and mRNA levels were unaffected by tranilast. CONCLUSIONS: Tranilast suppressed chymase gene expression, which was specifically activated in the injured arteries, and prevented neointima formation. Suppression of the chymase-dependent ANG II-forming pathway may contribute to the beneficial effects of tranilast.  (+info)

Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. (3/477)

To investigate the roles of calcium-binding proteins in degranulation, we used three anti-allergic drugs, amlexanox, cromolyn and tranilast, which inhibit IgE-mediated degranulation of mast cells, as molecular probes in affinity chromatography. All of these drugs, which have different structures but similar function, scarcely bound to calmodulin in bovine lung extract, but bound to the same kinds of calcium-binding proteins, such as the 10-kDa proteins isolated in this study, calcyphosine and annexins I-V. The 10-kDa proteins obtained on three drug-coupled resins and on phenyl-Sepharose were analysed by reversed-phase HPLC. It was found that two characteristic 10-kDa proteins, one polar and one less polar, were bound with all three drugs, although S100A2 (S100L), of the S100 family, was bound with phenyl-Sepharose. The cDNA and deduced amino acid sequence proved our major polar protein to be identical with the calcium-binding protein in bovine amniotic fluid (CAAF1, S100A12). The cDNA and deduced amino acid sequence of the less-polar protein shared 95% homology with human and mouse S100A13. In addition, it was demonstrated that the native S100A12 and recombinant S100A12 and S100A13 bind to immobilized amlexanox. On the basis of these findings, we speculate that the three anti-allergic drugs might inhibit degranulation by binding with S100A12 and S100A13.  (+info)

Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers. (4/477)

AIMS: To study whether desensitization occurs after long-term administration of the 1-adrenoceptor partial agonist xamoterol and, if so, whether this can be influenced by ketotifen. METHODS: In a double-blind, randomized design 10 young, healthy males received ketotifen (2 x 1 mg day(-1) p.o.) or placebo for 3 weeks with xamoterol (2 x 200 mg day(-1) p.o.) administered concomitantly during the last 2 weeks. 'l1-adrenoceptor mediated responses were assessed as exercise-induced tachycardia and isoprenaline-induced shortening of heart rate corrected electromechanical systole (QS2c); isoprenaline-induced tachycardia was measured as a mixed beta1-/beta2-adrenoceptor-mediated effect. RESULTS: The first dose of xamoterol significantly increased resting heart rate and systolic blood pressure and significantly shortened QS2c. The last dose of xamoterol after 2 weeks of treatment still produced the same responses. Ketotifen did not influence these effects of xamoterol on resting haemodynamics. The first dose of xamoterol caused a rightward shift of the exercise- and isoprenaline-induced tachycardia (mean dose ratios+/-s.e.mean: 1.20+/-0.05 and 2.46+/-0.23) and the isoprenaline-evoked shortening of QS2c (dose ratio 3.59+/-0.68). This rightward shift was even more pronounced after 2 weeks xamoterol treatment. This additional rightward shift after 2 weeks of xamoterol was not affected by ketotifen (mean difference (95% CI) of log transformed dose ratios between placebo and ketotifen: exercise tachycardia 0.001 (-0.03; 0.04); isoprenaline tachycardia 0.03 (-0.15; 0.21); isoprenaline induced shortening of QS2c 0.13 (-0.22; 0.48)). CONCLUSIONS: In humans xamoterol is a partial beta1-adrenoceptor agonist with positive chrono- and inotropic effects at rest and antagonistic properties under conditions of beta-adrenoceptor stimulation. These effects were well maintained after chronic dosing with no signs of beta1-adrenoceptor desensitization. Ketotifen does not change the beta-adrenoceptor mediated responses of xamoterol after chronic dosing.  (+info)

Comparison of intranasal triamcinolone acetonide with oral loratadine in the treatment of seasonal ragweed-induced allergic rhinitis. (5/477)

A double-blind, randomized, multicenter, parallel-group controlled study compared the efficacy and safety of intranasal triamcinolone acetonide (220 micrograms/day) and oral loratadine (10 mg/day) in patients with at least two seasons of ragweed-induced seasonal allergic rhinitis. A 28-day screening period, including a 5-day baseline period, preceded a 4-week treatment period. Reduction in rhinitis symptom scores was evident in both groups as early as day 1, with no significant between-group differences during week 1. At weeks 2, 3, and 4, patients treated with triamcinolone acetonide were significantly (P < 0.05) more improved in total nasal score, nasal itch, nasal stuffiness, and sneezing than were patients treated with loratadine. At weeks 3 and 4, rhinorrhea and ocular symptoms were significantly (P < 0.05) more improved from baseline among triamcinolone acetonide patients compared with loratadine patients. There was no significant between-group difference in relief from postnasal drip at any time point. Physicians' global evaluations significantly (P = 0.002) favored triamcinolone acetonide at the final visit, with moderate to complete relief of symptoms attained by 68% of triamcinolone acetonide patients and 59% of loratadine patients. Over the 4-week treatment period, triamcinolone acetonide patients had significantly greater improvement in total nasal score, nasal itch, nasal stuffiness, sneezing, and ocular symptoms. Both treatments were well tolerated, with headache being the most frequently reported drug-related adverse effect in both the triamcinolone acetonide (15%) and loratadine (11%) groups. These results indicate that triamcinolone acetonide is more effective than oral loratadine in relieving the symptoms of ragweed-induced seasonal allergic rhinitis.  (+info)

Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. (6/477)

Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. Despite a steady increase in the incidence, morbidity, and mortality from asthma, no current treatment can reduce or prevent asthma for a prolonged period. We examined the ability of unmethylated CpG oligodeoxynucleotides (ODN), which are potent inducers of Th1 cytokines, to prevent the inflammatory and physiological manifestations of asthma in mice sensitized to ragweed allergen. Administration of CpG ODN 48 h before allergen challenge increased the ratio of IFN-gamma to IL-4 secreting cells, diminished allergen-induced eosinophil recruitment, and decreased the number of ragweed allergen-specific IgE-producing cells. These effects of CpG ODN were sustained for at least 6 wk after its administration. Furthermore, there was a vigorous Th1 memory response to the recall Ag, inhibition of peribronchial and perivascular lung inflammation, and inhibition of bronchial hyperresponsiveness 6 wk after administration of CpG ODN. Administration of CpG ODN in IFN-gamma -/- mice failed to inhibit eosinophil recruitment, indicating a critical role of IFN-gamma in mediating these effects. This is the first report of a treatment that inhibits allergic lung inflammation in presensitized animals for a prolonged period and thus has relevance to the development of an effective long term treatment for asthma.  (+info)

Adhesive explant culture of allergic nasal mucosa: effect of emedastine difumarate, an anti-allergic drug. (7/477)

Allergic reaction of the nose comprises of an immediate and a late reaction. To evaluate nasal allergic reactions, many experiments have been performed by investigators. In this study, we performed a new tissue culture technique (adhesive explant culture) to analyze the migration of cells into the culture medium from the cultured allergic nasal mucosa in response to an allergen. Basophilic cells (mast cells and basophils) and eosinophils, which were released into the culture medium after the allergen challenge, were evaluated by the analysis of histamine and eosinophil cationic protein (ECP) content in the culture medium. Histamine and basophilic cells in the culture medium were more abundant in the immediate phase (within 30 min) after challenge than in the late phase (from 30 min to 10 hr). On the other hand, ECP and eosinophils in the culture medium were more abundant in the late phase than in the immediate phase. The increase of histamine content in both phases were not inhibited by pre-treatment of emedastine difumarate (EME), an anti-allergic drug. However, the increase of ECP in the late phase was inhibited by pre-treatment with EME. Moreover, the number of EG2-positive cells was also decreased by pre-treatment with EME. These results suggest that EME might lower the activation of eosinophils in the late phase of the allergic reaction. The present study also indicates that this adhesive explant culture system is useful model for studying the cellular allergic responses to drugs ex vivo.  (+info)

Effect of an orally active Th1/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice. (8/477)

We have found a novel anti-allergic agent, M50367, which suppresses IgE biosynthesis and eosinophil accumulation in vivo. In this study, we evaluated the ability of M50367 to modulate Th1/Th2 balance in Th2-background BALB/c mice and to inhibit airway hyperresponsiveness in a murine model of atopic asthma. Oral M50367 at 3-30 mg/kg/day exhibited 51 to 73% reduction of IL-4/IL-5 production and 2- to 5-fold augmentation of IFN-gamma production by Ag-stimulated cultured splenocytes of the mice sensitized with DNP-Ascaris. These alterations in Th1/Th2 cytokine production were accompanied by 55-85% suppression of plasma IgE level. Oral M50367 at a dose of 10 mg/kg/day significantly inhibited Ig-independent peritoneal eosinophilia by 54%, which was induced by repeated i.p. injections of Ascaris suum extract. To develop airway hyperresponsiveness caused by allergic airway inflammation, BALB/c mice were sensitized with i.p. OVA injections, followed three times by OVA inhalation. Oral M50367 significantly inhibited the increase in airway reactivity to acetylcholine, together with the elevation of plasma IgE level and pulmonary eosinophilia, which were observed in vehicle-treated mice 1 day after the last inhalation. Moreover, M50367 treatment reduced IL-4 and IL-5 production and tended to enhance IFN-gamma production, not only by cultured splenocytes, but also in bronchoalveolar lavage fluid. These results suggest that M50367 has a modulating ability of Th1/Th2 balance to down-regulate Th2 response in the circulating system as well as at the sites of inflammation, and may be beneficial for the treatment of allergic disorders such as atopic asthma.  (+info)

*Monoclonal antibody therapy

Solanezumab, an anti-aβ MAB, targets the N-terminus of Aβ. In Phase I and Phase II of clinical trials, Solanezumab treatment ... Systemic administration of a non-toxic agent results in the antibody's conversion to a toxic drug, resulting in a cytotoxic ... Omalizumab inhibits human immunoglobulin E (IgE) and is useful in moderate-to-severe allergic asthma. Alzheimer's disease (AD) ... Bapineuzumab, a humanized anti-aβ MAB, is directed against the N-terminus of Aβ. Phase II clinical trials of Bapineuzumab in ...

*H1 antagonist

Nelson, Wendel L. (2007). "Antihistamines and Related Antiallergic and Antiulcer Agents". In William O. Foye, Thomas L. Lemke ... These indications may include: Allergic rhinitis Allergic conjunctivitis Allergic dermatological conditions (contact dermatitis ... helping to relieve from allergic reactions. Agents where the main therapeutic effect is mediated by negative modulation of ... These agents also commonly have action at α-adrenergic receptors and/or 5-HT receptors. This lack of receptor selectivity is ...

*Loratadine

Nelson, Wendel L. (2002). "Antihistamines and related antiallergic and antiulcer agents". In Williams, David H.; Foye, William ... For allergic rhinitis (hay fever), loratadine is effective for both nasal and eye symptoms: sneezing, runny nose, itchy or ... This includes allergic rhinitis (hay fever) and hives. It is also available in combination with pseudoephedrine, a decongestant ... Serious side effects are rare and include allergic reactions, seizures, and liver problems. Use during pregnancy appears to be ...

*Pipethiaden

"Anti-allergic Properties of Pipethiaden-a New Preventive Agent for Migraine". Československá Farmacie (in Czech). 38 (6): 264-8 ...

*Pirquinozol

"Anti-allergic properties of pirquinozol (SQ 13,847) an orally effective agent. Evaluation in an anti-IgE-induced pulmonary ... Free CA, Hall LE (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. II. Activity in vitro". The ... Casey FB, Abboa-Offei BE, Marretta J (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. I. Activity ... Pirquinozol (SQ-13,847) is a drug which was investigated as an antiallergen and antiasthmatic agent in the early 1980s but was ...

*Ketotifen

"Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and ... O]ral ketotifen has been used in patients with asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, chronic ... www.mims.co.uk/drugs/allergic-disorders/allergic-rhinitis-urticaria-other-allergies/zaditen Kakiuchi M, Ohashi T, Musoh K, ... In its ophthalmic form, it is used to treat allergic conjunctivitis. In its oral form, it is used to prevent asthma attacks or ...

*Amlexanox

The drug is an anti-inflammatory, antiallergic immunomodulator. Its mechanism of action is not well-determined, but it might ... In Japan, it is used to treat bronchial asthma, allergic rhinitis and conjunctivitis. The drug is contraindicated in those with ... Nohara, A.; Ishiguro, T.; Ukawa, K.; Sugihara, H.; Maki, Y.; Sanno, Y. (1985). "Studies on Antianaphylactic Agents. 7. ... Amlexanox (trade name Aphthasol) is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers ( ...

*List of MeSH codes (D16)

... anti-allergic agents MeSH D27.505.954.122 --- anti-infective agents MeSH D27.505.954.122.085 --- anti-bacterial agents MeSH ... antiviral agents MeSH D27.505.954.122.388.077 --- anti-retroviral agents MeSH D27.505.954.122.388.077.088 --- anti-hiv agents ... renal agents MeSH D27.505.954.613.056 --- anti-infective agents, urinary MeSH D27.505.954.613.860 --- uricosuric agents MeSH ... anti-inflammatory agents MeSH D27.505.954.158.030 --- anti-inflammatory agents, non-steroidal MeSH D27.505.954.158.030.500 --- ...

*Proxicromil

This causes the compound to have anti-allergic properties. The condensation of 6-acetyl-7-hydroxy-1,2,3,4-tetrahydronaphthalene ... Furukawa, Clifton T. (1984). "Other pharmacologic agents that may affect bronchial hyperreactivity". Journal of Allergy and ... It supresses allergic reactions by binding to FcεRI receptor in mast cells, thereby inhibiting production of histamines. It is ... Allergic reactions or responses to inflammation or invading microorganisms are coordinated by these cells in a process called ...

*Gleditsia sinensis

... in mice suggest that Gleditsia sinensis ethanolic extract could be an effective therapeutic agent for the treatment of allergic ... Chui C.H., Gambari R., Lau F.Y., Teo I.T.N., Ho K.P., Cheng G.Y.M., Ke B., Higa T., Kok H.L., Chan A.S.C., Tang J.C.O."Anti- ... Li W.-H., Zhang X.-M., Tian R.-R., Zheng Y.-T., Zhao W.-M., Qiu M.-H.,"A new anti-HIV lupane acid from Gleditsia sinensis Lam ... A lupane acid extracted from the thorns showed in vitro anti-HIV activity. The fruit extract of Gleditsia sinensis also has ...

*Tse Wen Chang

Chang TW, Wu PC, Hsu CL, Hung AF, 2007, "Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases." Advances in ... Chang TW and Shiung YY, 2006, "Anti-IgE as a mast cell-stabilizing therapeutic agent." The Journal of Allergy and Clinical ... Chang is a cofounder of Tanox, a biopharmaceutical company specialized in anti-IgE therapies for the treatment of allergic ... antibodies that target the IgE-mediated allergic pathway have proven effective in the treatment of various allergic diseases. ...

*Allergic conjunctivitis

Treatment consists of antihistamine, mast cell stabilizers, dual mechanism anti-allergen agents, or topical antihistamines. ... Both seasonal allergic conjunctivitis and perennial allergic conjunctivitis are two acute allergic conjunctival disorders. SAC ... The cause of allergic conjunctivitis is an allergic reaction of the body's immune system to an allergen. Allergic ... Allergic conjunctivitis occurs more frequently among those with allergic conditions, with the symptoms having a seasonal ...

*Soy sauce

... is rich in lactic acid bacteria and of excellent anti-allergic potential. Soy sauce does not contain the level of ... but it is difficult to make soy sauce without using some quantity of salt as an antimicrobial agent. A serving of 100 ml of soy ... Kobayashi, Makio (18 April 2005). "Immunological Functions of Soy Sauce: Hypoallergenicity and Antiallergic Activity of Soy ...

*Kolliphor EL

... anti-cancer Allergic reactions to Taxol are most often allergic reactions to Kolliphor EL; symptoms include tightness in the ... intravenous anaesthetic agent, originally presented in Kolliphor EL for trials; now presented in a lipid emulsion Diazepam ... Miconazole, anti-fungal Paclitaxel, anti-cancer Docetaxel, anti-cancer Aci-Jel (acetic acid / oxyquinoline / ricinoleic acid - ... The allergic reaction is usually immediate and is similar to severe allergic reactions of many other substances that trigger ...

*Anti-inflammatory

Antileukotrines are anti-inflammatory agents which function as leukotriene-related enzyme inhibitors (arachidonate 5- ... Dery, R.E.; Mathison, R.; Davison, J.; Befus; A.D. (2001). "Inhibition of allergic inflammation by C-terminal peptides of the ... More recently plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent in ... Those following an anti-inflammatory diet will avoid refined oils and sugars, and show a preference for so-called anti- ...

*Urushiol-induced contact dermatitis

For people who have never been exposed or are not yet allergic to urushiol, it may take 10 to 21 days for a reaction to occur ... Poison ivy Contact dermatitis Anti-itch drug Toxin List of cutaneous conditions Lepoittevin, J.-P., Benezra, C., Asakawa, Y. ... Results for jewelweed as a natural agent for treatment are conflicting. Some studies indicate that it "failed to decrease ... Once allergic to urushiol, however, most people break out 48 to 72 hours after contact with the oil. Typically, individuals ...

*Equipment of a combat medic

Loperamide (Imodium AD) an anti-diarrheal agent. Pepto Bismol tablets, to settle upset stomachs, treat diarrhea, and heartburn ... Epi-pen, epinephrine in an auto injecting "pen" to counter anaphylactic (severe allergic) reactions. A combat medic is ... Hemostatic agents, such as Celox, Hemcon bandages, and others. Some hemostatic agents are controversial due to their ... acetaminophen (Tylenol), anti-pyretic and pain reducer. Naproxen and ibuprofen, different NSAIDs which reduce pain and ...

*Polygodial

da Cunha, F.M. et al., (2001). Additional evidence for the anti-inflammatory and anti-allergic properties of the sesquiterpene ... Polygodial, an anti-Candida agent from Pseudowintera colorata. Planta Med 1982; 44: 134-138. Muñoz-Conchaa, D., Vogelb, H., ... Tratsk, K.S. et al., (1997). Anti-allergic effects and oedema inhibition caused by the extract of Drymis winteri. Inflammation ... anti-inflammatory and antiallergic activities Polygodial's primary antifungal action is as a nonionic surfactant, disrupting ...

*Mometasone furoate

9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3. Austin RJ, Maschera B, Walker A, ... For allergies, corticosteroids reduce the allergic reactions in various types of cells (mastocytes and eosinophils) that are ... It is believed that the action of corticosteroid anti-inflammatory agents are bound to inhibitive proteins of phospholipase A2 ... Mometasone furoate can be used with formoterol for the treatment of asthma, due to its anti-inflammatory properties. Mometasone ...

*Bufexamac

... is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm ... It was withdrawn in Europe because of allergic reactions. Ointments and lotions containing bufexamac are used for the treatment ... Bufexamac is thought to act by inhibiting the enzyme cyclooxygenase, which would make it a non-steroidal anti-inflammatory drug ...

*Sulfonamide (medicine)

... anti-inflammatory agent and a DMARD) Sumatriptan (antimigraine triptan) Tamsulosin (α blocker) Udenafil (PDE5 inhibitor) ... When used in large doses, they may cause a strong allergic reaction. Two of the most serious are Stevens-Johnson syndrome and ... A key component to the allergic response to sulfonamide antibiotics is the arylamine group at N4, found in sulfamethoxazole, ... Other sulfonamide drugs do not contain this arylamine group; available evidence suggests that patients who are allergic to ...

*Cysteinyl leukotriene receptor 1

These drugs are in use and/or shown to be effective as prophalaxis and chronic treatments for allergic and non-allergic ... of patients reporting no change in symptoms after treatment with these agents. It seems possible that the responses of CysLTR2 ... diseases such as: allergen-induced asthma and rhinitis; nonsteroidal anti-inflammatory drug-induced asthma and rhinitis (see ... Liu M, Yokomizo T (2015). "The role of leukotrienes in allergic diseases". Allergology International. 64 (1): 17-26. doi: ...

*Triethanolamine

2-3% in water TEA is used as an corrosion inhibitor (anti-rust) agent in immersion ultrasonic testing. A 1996 study found that ... A 2001 study found TEA in a sunscreen caused an allergic contact dermatitis. A 2007 study found TEA in ear drops caused a ... Another common use of TEA is as a complexing agent for aluminium ions in aqueous solutions. This reaction is often used to mask ... TEA is used to provide a sensitivity boost to silver-halide-based holograms, and also as a swelling agent to color shift ...

*Alcohol-induced respiratory reactions

... a sulfur dioxide-related agent, or an agent whose levels in alcohol beverages correlated positively with those of sulfur ... These allergic reaction-like symptoms, which typically occur within 30-60 minutes of ingesting alcoholic beverages, do not ... and by nonsteroidal anti-inflammatory drugs (NSAID) other than aspirin. The study suggested the salicylate-"contaminates" in ... The prevalence of ethanol-induced allergic symptoms in non-Asian genotypes commonly ranges above 5% even though many of these ...

*Human anti-mouse antibody

The HAMA response is essentially an allergic reaction to the mouse antibodies that can range from a mild form, like a rash, to ... due to the preponderance of medical agents made from the serum of animals. Monoclonal antibodies can be generated for human use ... Human anti-mouse antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice. Antibody treatment ... It took considerable, sustained pressure from animal welfare groups, led by legal efforts initiated by the American Anti- ...

*Mylanta

Other Mylanta-branded products include: Mylanta Tonight Liquid Antacid/Anti-Gas Mylanta Gas Minis. "Mylanta Maximum Strength ... these concerns stemmed from the fact that small traces of alcohol were found in the flavoring agents of the liquid version of ... and trouble breathing are signs of an allergic reaction and should be treated immediately by a medical professional. Mylanta ... Liquid Antacid/Anti-Gas". "Mylanta during Pregnancy". April 3, 2011. Archived from the original on April 5, 2011. "News , ...

*MCD peptide

... provide a base for designing agents that can prevent IgE/Fc-RIa interactions and reduce allergic conditions. Argiolas, A; ... At higher concentrations, it has anti-inflammatory propterties. In addition, it is a potent blocker of voltage-sensitive ... These actions of MCD peptide on mast cells is thought to be involved in allergic and inflammatory processes related to type I ... at higher concentrations it displays anti-inflammatory activities. Through its effect on ionic channels, MCD peptide can induce ...
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BioAssay record AID 179614 submitted by ChEMBL: Antiallergic activity in rat reaginic passive cutaneous anaphylaxis (PCA) test upon intravenous administration.
Pentaherb formula (PHF) has been proven to improve the quality of life of children with atopic dermatitis without side effects. The aim of this study was to elucidate the potential anti-inflammatory and anti-allergic activities of PHF, Moutan Cortex (Danpi/DP) and gallic acid (GA) using human basophils (KU812 cells), which are crucial effector cells in allergic inflammation. PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p | 0.05). With the combined use of dexamethasone (0.01 μg/mL) and GA (10 μg/mL), the suppression of ICAM-1 expression and CCL5 and IL-6 release of IL-33-activated KU812 cells were significantly greater than the use of GA alone (all p | 0.05). The suppression of the IL-33-induced activation of intracellular signalling molecules p38 mitogen activated protein kinase, nuclear factor
Two hundred and ten patients with chronic urticaria were divided into two groups; one group was treated with Loratadine 10mg daily while the other with
Guest Editors who wish to submit an issue proposal to Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry are requested to complete the following online form. The proposal of thematic issue will then be immediately forwarded to the Editor-in-Chief/Co-Editors/Executive Editor(s) of Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry who will then inform Guest Editors with a decision about the submitted proposal.. ...
Clinical Anti-Inflammatory & Anti-Allergy Drugs publishes original research, expert reviews, drug clinical trials and thematic issues in all core areas of translational and clinical anti-inflammatory & anti-allergy drug research.
The program of restoration and preservation of health developed by the Academy of Health Coral Club. Based on the book O.A .Butakova "Compendium of health programs.". Nutritsiologikal and rehabilitation programs developed by doctors of various specialties and are based on the natural means of the highest quality.. Combination Three (Gathering herbs number 3) - 1 tablet 2 times a day, can be dissolved in 1 cup of warm water and drink as tea. Relieves pain and spasms. Stimulates blood flow to the patient body while cleansing it provides sputum from the airways and make breathing easier.. Licorice root (LicoriceRoot) - 1 tablet dissolved in 1 cup water and drink as a tea three times a day. Immunomodulatory and has a tonic effect that blogotvorno affect the function of the bronchi. The drug has protivovospalitlnym and antiallergic activity.. Colloidal Silver (Silver-Max) - 1/2 tsp 3 times per day. Natural antiseptic.. Garlic (Garlic) - 1 capsule 2 times a day with meals. It helps neutralize ...
Allergies can be topical, respiratory, or digestive, and result in an immune system overreaction to a substance. This can release histamines, which cause wheezing, rashes, sneezing, vomiting, and even anaphylactic shock. People can be allergic to specific foods, plants, animals, and chemicals. Human studies are lacking, and more research is necessary on the anti-allergy potential of various herbs.. Hay fever is a seasonal allergy to pollens and fungi in the air, and can irritate the nose, throat, and eyes. ...
The anti-allergy drug FPL 52757 (Fisons Ltd. ,) 6,8-diethyl-5-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid produced mild and reversible hepatotoxicity in some patients during clinical trials. The purpose of this work was to elucidate the mechanism by which FPL 52757 caused hepato-toxicity. However, since further humans could not be tested the work is limited to animal models. Toxicity studies showed that the beagle dog was the only animal species of ten tested which was readily susceptible to the hepatotoxic effect of the compound. In this project hepatotoxicity could not be demonstrated in ferrets or rats in special studies designed to reduce resistance to drug-induced hepatotoxicity. Similarly, hepatic microsomal enzyme induction in dogs by pretreatment with phenobarbitone and protection against cytotoxicity by pretreatment with methionine provided no evidence for involvement of a reactive metabolite in the hepatoxicity. Work by Fisons and additional studies in this project showed that the ...
Adenosine potentiated anaphylactic histamine release from isolated rat mast cells in a dose-dependent manner between 10−8 and 10−5 M. Adenosine was found to be present during a normal incubation of...
Greenmedinfo.com - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
Allergic disease decreases the daily quality of life of many people, and can increase the number of working days lost owing to sick leave. Associated symptoms with allergic disease depend on the origin of the disease, and can either be allergic, non-allergic and purulent, or can cause rhinitis as a result of a common cold. Treatment depends on the origin of the rhinitis. However, an antihistamine is indicated in most instances. Combination treatment includes sympathomimetic drugs (either local or systemic) and corticosteroid medication (when indicated, and in most instances, used locally). The article provides an overview of the nature and the management of allergic disease and the histamine 1 antihistamines.
Lesperidina è un flavanone glicosilato, un tipo di flavonoide che si trova soprattutto allinterno dei frutti degli agrumi. È in particolar modo abbondante nella buccia e nella polpa di tali frutti. Il suo aglicone è chiamato esperetina. Si pensa che allinterno della pianta lesperidina abbia funzioni di difesa, fungendo, secondo gli studi in vitro, da antiossidante. Introdotto nella dieta umana, lesperidina si è dimostrata un valido vasoprotettore aumentando lefficienza del collagene e del tessuto connettivo. I. Baranowska, S. Magiera, Analysis of isoflavones and flavonoids in human urine by UHPLC., in Anal Bioanal Chem, vol. 399, nº 9, Mar 2011, pp. 3211-9, DOI:10.1007/s00216-010-4206-6, PMID 20936271. HJ. Jeong, Y. Choi; KY. Kim; MH. Kim; HM. Kim, C-Kit Binding Properties of Hesperidin (a Major Component of KMP6) as a Potential Anti-Allergic Agent., in PLoS One, vol. 6, nº 4, 2011, pp. e19528, DOI:10.1371/journal.pone.0019528, PMID 21559359. L. Quintieri, S. Bortolozzo; S. ...
Tranilast is is an antiallergic drug. In-vitro it reduces collagen synthesis in fibroblasts,[2] and inhibits growth of neurofibroma cells. In-vitro it inhibits the production of interleukin-6 in endothelial cells ...
Sujiaonori, a river alga growing in the Kochi prefecture, Japan, contains several bioactive compounds such as sulfated polysaccharides (ulvans), ω-3 fatty acids, and vitamins. Dietary intake of this alga-based supplement has been reported to increase circulatory adiponectin, a salutary hormone that is reported to be associated with healthy longevity and prevents a number of cardiovascular and metabolic disorders. This report highlights the anti-allergic and skin health enhancing effects of Sujiaonori-derived ulvan (Tosalvan) and supplement, respectively. RBL-2H3 cell line was used to investigate the anti-allergic effect of algal SP through the evaluation of β-hexosaminidase activity. Algal sulfated polysaccharides or SP (Tosalvan, Yoshino SP) were extracted from powders of dried alga samples provided by local food manufacturers. Report on the effect of daily dietary intake of Sujiaonori-based supplement on skin health is part of a four-week clinical investigation that, in comparison with a supplement
Prednisolon the anti-inflammatory, anti-allergic, immunosuppressive. It affects various types of exchanges: providing a catabolic effect, increases blood glucose levels, promotes redistribution of fat tissue, causing retention of sodium and water in the body
1-Piperidinylmethyl benzenamines represented by the formula: ##STR1## wherein X is S or --CH2 --CH2 --; R1 and R2 are the same different members of the group consisting of hydrogen or lower alkyl; and the pharmaceutically acceptable salts thereof. The compounds are useful as anti-allergic and antihypertensive agents.
If you struggle with allergy symptoms like a stuffy, runny nose, sneezing, irritable eyes or an itchy throat, youre not alone - around one in five people in Australian and New Zealand suffer from allergic rhinitis.[1]. ...
Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma ...
Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma ...
Salmon are one of the highest source omega 3 fatty acid. Omega 3 can fight off inflammation and lessen allergy symptoms. Salmon can also increase lung function. This is great for people who suffer from asthma attack or cold like allergy symptoms. Eat at least two portions of salmon or other high in Omega 3 fishes a week.. Sweet Potatoes ...
Composition: POLLINEX® Trees contains glutaraldehyde-modified, standardised allergen extracts (allergoids) of 3 common tree pollens.. Indications: POLLINEX® Trees is an anti-allergy vaccine indicated for treatment of seasonal allergic hayfever due to tree pollen in patients who have failed to respond adequately to anti-allergy drugs. Diagnosis should be based on the careful consideration of the patient history and allergy tests, preferably skin tests.. Method of Administration: POLLINEX® Trees is formulated as a slow release subcutaneous injection.. Presentation: POLLINEX® Trees is presented in vials.The packs available are as follows: • Initial Course: 3 vials (No. 1 - No. 3) containing graduated doses (300 standardised units (SU)/0.5 ml (No.. - Flexible therapy with L-Tyrosine adsorbed allergoids. 1), 800 SU/0.5 ml (No. 2) and 2,000 SU/0.5 ml (No. 3)). • Extension Course: 1 vial of the No. ...
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The research by the University of Birmingham in the UK could lead to new treatments that prevent deep vein thrombosis (DVT), a blood clot that develops within a deep vein in the body, usually in the leg, and causes swelling, aching and difficulty walking.
The drugs can prevent the blood clots from going all the way up to the lungs from the leg to infect the lungs and subsequently cause pulmonary embolism.
The goose down and -feathers which Hex Valley Down uses, remain undamaged and in its natural state over a period of time that might even outlive you. Our cleaning process ensures that the filling is thoroughly washed - removing all dust and dirt. In addition, its sterilized and treated with an SABS-approved anti-allergic agent before filling the products. ...
Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to something in the environment that usually causes little or no problems to most people. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing and a runny nose, shortness of breath or swelling. Food intolerances and food poisoning are separate conditions.
While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known. We examined the effect of 70% ethanol extract of Chaga mushroom (EE) and its dichloromethane (DF) and aqueous (AF) fractions using a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and found that only EE and DF ameliorated allergy symptoms to a significant extent. The in vivo mast cell-stabilizing activity was also found only in EE and DF whereas the activities to suppress Th2 and Th17 immune responses and cOVA-specific IgE production in the small intestine were observed in all three treatment regimens, implying that inhibition of the mast cell function by lipophilic compounds was vital for the therapeutic effect ...
Himalaya Purim tablets has various constituents that have antiseptic, antibacterial, antifungal, anti-inflammatory, antiviral, hepatic stimulant, wound healing and anti-allergic properties. Most of Himalaya Purims constituents are used in the treatment o
At recommended doses, has a pronounced anti-inflammatory, anti-edema and anti-allergic effect. Anti-inflammatory effect is realized by the interaction of the drug with the receptors glucocorticosteroids. Inhibits proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils, reduces the production and release of mediators of inflammation and other testosterone cypionate vs enanthate biologically active agents (including histamine, prostaglandins, leukotrienes,… ...
It has been used for many centuries as a treatment for ailments. It is also used to reduce cholesterol and blood pressure. It is believed to have anti-allergic properties, and is used as a remedy for arteriosclerosi. It also relieves spasms of the smooth muscle in the walls of the internal organs, making it valuable for gallbladder problems. Researchers have found it to be mildly antiseptic as well.. ...
Antiallergic asthma Avail discounts for your favorite herbal medicine for order the best in herbal nutritional supplements and drugs. Where to buy rhinocortBuy Rhinocort online no prescription - nasal spray.
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Montek lc anti allergy medicine what are the side effect on long term use - Is there a side-effect in taking anti-allergy medicine for a long time, like 6 months? Generally not. Many people take allergy mede for yrs and yrs. It only treats te symptoms and does nothing to address underlying causes of allergies. Nutrition is important. Supporting immune system is important. Allergy shots or sublingual drop therapy would be a better long term solution.
Ketotifen is a relatively selective, non-competitive histamine antagonist (H1-receptor) and mast cell stabilizer. Ketotifen inhibits the release of mediators from mast cells involved in hypersensitivity reactions. Decreased chemotaxis and activation of eosinophils have also been demonstrated. Ketotifen also inhibits cAMP phosphodiesterase. Properties of ketotifen which may contribute to its antiallergic activity and its ability to affect the underlying pathology of asthma include inhibition of the development of airway hyper-reactivity associated with activation of platelets by PAF (Platelet Activating Factor), inhibition of PAF-induced accumulation of eosinophils and platelets in the airways, suppression of the priming of eosinophils by human recombinant cytokines and antagonism of bronchoconstriction due to leukotrienes. Ketotifen inhibits of the release of allergic mediators such as histamine, leukotrienes C4 and D4(SRS-A) and PAF.. ...
TY - JOUR. T1 - Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice. AU - Shieh, Ying Hua. AU - Huang, Huei Mei. AU - Wang, Ching Chiung. AU - Lee, Chen Chen. AU - Fan, Chia Kwung. AU - Lee, Yueh Lun. PY - 2015. Y1 - 2015. N2 - Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and traditional medicine. Zerumbone was shown to possess anticarcinogenic, anti-inflammatory, and antioxidant properties. However, the antiallergic activity and the underlying mechanism of zerumbone have not been reported. Herein, we investigated the immunomodulatory effects of zerumbone on antigen-presenting dendritic cells (DCs) in vitro and its potential therapeutic effects against ovalbumin (OVA)-induced T helper 2 (Th2)-mediated asthma in mice. In the presence of zerumbone, lipopolysaccharide-activated bone marrow-derived DCs enhanced T cell proliferation ...
Top Quality 99% Amlexanox Cas:68302-57-8 Amlexanox English name: Amlexanox Amlexanox CAS Number: 68302-57-8 Amlexanox Molecular formula: C16H14N2O4 Amlexanox Molecular weight: 298.29 Amlexanox EINECS number: Amlexanox Related categories:...
Epinastine 0.05% eye drops are used for ocular itching associated with conjunctivitis. Order at our pharmacy and save upto $56.98.
Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population.
The present study is to investigate the effect of cornuside on mast cell-mediated allergic response, as well as its possible mechanisms of action.To test the anti-allergic effects of cornuside in vivo, local extravasation was induced by local injection of anti-dinitrophenyl immunoglobulin E (IgE) followed by intravenous antigenic challenge in passive cutaneous anaphylaxis model rats. Mast cell via ...
Phenergan contains the medicine promethazine, and is used to treat a wide range of symptoms ranging from combat allergic symptoms to being used as a sleep aid. Predator Nutrition
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Prednisolone is a hormone drug which provides an action to most functions of the body. It shows an anti-inflammatory, and anti-allergic action. Buy Prednisolone online.
Bacopa is a great tranquilizing, memory and learning enhancing, cerebral activator, anti-ulcer, neurotonic, immuno-modulator, adaptogen,antispasmodic, anti-asthmatic ayurvedic herb. Other benefits are anti-allergic action, and free radicals scavenging effect as herbal supplement in Epilepsy, anxiety and depression. Know its beneficial actions on brain, learning skills, anxiety, depression, stress, epileps memory, mental deficiency, Alzheimers disease,and ADHD children. http://www.holistic-herbalist.com/bacopa.html ...
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Consumer information about the medication LODOXAMIDE - OPHTHALMIC (Alomide), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug LODOXAMIDE - OPHTHALMIC.
The risk of hyponatremia is not particularly high. Beware more of dehydration than hyponatremia. Nevertheless, you should not drink constantly. Its a good idea to have a drink at the pace of the drink points on the marathon route.. If a beginner runs the marathon very slowly, there is less heat in the body and less fluid is consumed. If you always drink a couple of cups at resting places and then drink some extra of your own drinks just in case, you may have too much fluid load.. When sweating on a hot day, also non-fitness enthusiasts should take care of hydration properly. And beware, you need to be careful with alcohol, as it drains your body.. Excess weight and several drugs may increase the symptoms of heat. These include, for example, anti-allergic drugs, beta-blockers, antidotes, and de-icing agents. Avoid taking any drugs like aspirin, ibuprofen and naproxen (NSAIDS) before or during a race if at all possible. These drugs increase the risk for exercise-associated hyponatremia and acute ...
Antiallergic medications are used to inhibit hypersensitivity in the allergy-predisposed individuals. They are blocking histamine receptors, responsible for allergic response development.
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Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: R1 is hydrogen, C1-6 alkyl or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydroxy, nitro, cyano, C2-10 acyloxy, NR6 R7 wherein R6 and R7 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl; or COR8 wherein R8 is hydroxy, C1-6 alkoxy or NR9 R10 wherein R9 and R10 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen, halogen, CF3, C1-4 alkoxy, C1-4 alkyl or any of the groups listed for R3 ; and R5 is hydrogen, C1-4 alkyl or benzyl optionally substituted in the phenyl ring by halogen, CF3, C1-4 alkoxy or C1-4 alkyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory and/or anti-allergy activity, and their use as pharmaceuticals.
As an active athlete, I had breathing problems, i.e. inadequate nasal airflow, on exercise in particular. This in turn led to frequent and deliberate blowing my nose and headache; I had a feeling of reduced airflow. I tried all the nasal hygiene products available and anti-allergy treatments, without success. The more so, my condition worsened from year to year. Then I visited Klapan Polyclinic at mid-August 2009 and was operated on within 2 weeks. I am very grateful to Professor Klapan and his surgical team, nurses in particular, for all their kindness, cordiality and assistance. The best of all, however, is the feeling that now, after the surgery, all my problems have vanished and I can normally breathe on both nostrils. The difference is most pronounced during my high-exercise trainings, when my nose "works even better". In a word, the service offered to me by Klapan Polyclinic has substantially changed my life and I thank them all from the bottom of my heart, bless them!. R. I., pupil, born ...
It shut out pollen and the fine particles of the exhaust gas and is effective in an anti-allergy measure.. * There is not it in the genuine disposable item, and recycling is possible. ...
A selected ion monitoring method for the estimation of an anti-allergy compound isamaxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable analogue containing nine deuterium atoms
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Omalizumab is an FDA approved anti-IgE drug used to treat allergic asthma. This study is designed to give omalizumab 13 weeks prior to administering rapid build up of specific allergy shot, with an overlap of omalizumab and cluster therapy for 3 weeks. The cluster therapy will take 4 week to complete with maintenance dosage lasting an additional 6 weeks ...
Ciclesonide is a corticosteroid. It prevents the release of substances in the body that cause inflammation. Ciclesonide is used to prevent asthma attacks in adults and children who are at least 12 years. Ciclesonide may also be used for purposes not listed in this medication guide.
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment ...
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Local treatment of antiseptic and anti-allergic rhinitis NASAL WAY Adult: 1 spray in each nostril 4 to 6 times a day. Child: 1 spray in each nostril 2 to 3 times a day. Infant: 1. Spraying in each nostril 1 to 2 times a day. The nasal sprays are done with the bottle in a vertical position.
Ceasing exposure to known allergens is the first step in anti-allergic treatment. Disposing of the allergen isnt constantly conceivable, as on account of dust sensitivities. Pharmaceuticals Different medications can alleviate the symptoms of rhinitis. Some are taken orally, others are nasal showers or eye drops (eye drops). On the off chance that over-the-counter items dont […]. ...
Ze Xie is also known as Alisma. The sweet, bland and cold herb has been used in TCM as anti-pyretic , as anti-bacterial, hypoglycemic, hypotensive, anti tumor, anti-allergic, etc., as it eliminates water, clear Heat, diuretic, etc., by enchaining the functions of bladder and kidney channels. Ingredients 1. Alisol A、B、C 2. Alosol A monoacetate 3. …. ...
It was my first on-line order! I always scared to lost money, to receive bad-quality product or that my parcel will be lost by post. But everything was good! My parcel arrived in selected day, in perfect condition, in professional package and I am using my anti-allergic pills already 3 weeks and result is great, so quality of medicine is also good. All that remains - to say thank you ...
It was my first on-line order! I always scared to lost money, to receive bad-quality product or that my parcel will be lost by post. But everything was good! My parcel arrived in selected day, in perfect condition, in professional package and I am using my anti-allergic pills already 3 weeks and result is great, so quality of medicine is also good. All that remains - to say thank you ...
Cov kab mob Mometasone yog cov kab mob glucocorticoid lossis corticosteroid los txo qhov mob ntawm daim tawv nqaij los yog hauv cov hlab cua. Nws yog ib tug prodrug ntawm daim dawb daim mometasone (INN).
Placebo-controlled randomised controlled trials (RCTs) that assessed the ocular efficacy of intranasal corticosteroids in patients with seasonal allergic rhinitis were eligible for inclusion in the review. Ocular efficacy could be assessed as a primary or secondary outcome or as part of a non-nasal symptom score (which included three ocular symptoms such as eye-itching, eye tearing, eye redness and ear/palate itching). Eligible intranasal corticosteroids were beclomethasone dipropionate, budesonide, ciclesonide, flunisolide, fluticasone furoate, fluticasone propionate, mometasone furoate and triamcinolone acetonide.. Ten of the included studies compared intranasal corticosteroids to placebo and also included an active comparator arm (another intranasal corticosteroids or antihistamine). Included patients included both males and females with mild to severe seasonal allergic rhinitis at baseline. Seasonal allergic rhinitis was due to various allergens (such as birch, ragweed, grass and mountain ...
1. A novel arctigenin-containing latex glove prevents latex allergy by inhibiting type I/IV allergic reactions. Wang YX, Xue DT, Liu M, Zhou ZM, Shang J. A novel arctigenin-containing latex glove prevents latex allergy by inhibiting type I/IV allergic reactions. Chinese Journal of Natural Medicines 2016; 14(3): 185-195. (doi:10.1016/S1875-5364(16)30015-2). Abstract. Wang and colleagues aimed at developing a natural compound with anti-allergic effect as well as stability under latex glove manufacturing conditions and investigated whether its anti-allergic effect could be maintained after its addition into the latex. The effects of nine natural compounds on growth of the RBL-2H3 cells and mouse primary spleen lymphocytes were determined using MTT assay. The compounds examined included glycyrrhizin, osthole, tetrandrine, tea polyphenol, catechin, arctigenin, oleanolic acid, baicalin and oxymatrine. An ELISA assay was used for the in vitro anti-type I/IV allergy screening; in this process ...
Phytother Res. 2014 Mar;28(3):471-4. doi: 10.1002/ptr.5020. Epub 2013 Jun 7. Randomized Controlled Trial; Research Support, Non-U.S. Govt
... is a medication used for relieving seasonal allergy symptoms. This eMedTV resource contains more information about fexofenadine and its uses, effects, and general dosing guidelines.
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Fexofenadine hydrochloride is the active ingredient in Allegra tablets and Allegra orally disintegrating tablets, according to RxList. It is also the active ingredient in Allegra oral suspension....
Home » Terfenadine. terfenadine (Science: chemical) A selective histamine h1-receptor antagonist devoid of central nervous system depressant activity. The drug is used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria. Pharmacological action: anti-allergic agents, anti-asthmatic agents, histamine h1 antagonists. Chemical name: 1-Piperidinebutanol, alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)- ...
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Rev. May200ai Brief Summary ALLEGRA0 (fexofenadine hydrochloride) Capsules and Tablets INDICATIONSAND USAGESeasonal Allergic Rhinitis A LlGRAis indicated for the relief of symp toms associated with seasonal allergic rhinitis in adults and children 6 years of age and older. Symptoms Ireated effectively were sneezing, rhinorrhea. itchy nose/palate/throat, idhy/watery/red eves Chronic Idiooathi Urticaia ALLEGRAis indicatedfor treatment of uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older. It significantly reduces pruritus and the number of wheals. CONTRAINDICATIONS AILEGRAis con traindicated in patients with known hypersensitivityto any of its ingredients PRECAUTIONSDrug Interaction with Erythromycn and Ketoconazole Fexolenadinmehydrochloride has been shown to exhihit minimal (cal 5)iimetabolism. However, co administration ol fexofenadine hydrochloride with ketoconazole and erythronmrin led to increased plasma levels of fexofenadine ...
... What is fexofenadine? Fexofenadine hydrochloride (usually shortened to fexofenadine) is often used for hay fever. Its a non-drowsy antihistamine that can help to relieve symptoms of allergies. Some of the other conditions that fexofenadine
Thanks Kofi, interesting stuff. CB 2 agonists demonstrate remarkable anti inflammatory properties but your idea of receptor attraction has some merit, at least with respect to the CB 1 receptor. I recall an old study wherein they found that cannabis tolerance was proportional to the level of receptor retraction from the cell surface. This does raise some worrying questions with respect to the chronic ingestion of the same but the studies tend to find little ill effects. Cannabidol, the non-psychoactive form, strikes me as an excellent target for therapeutic potential. A recent news release about some research indicated that topical application of THC, which does ligand to the CB 2, had strong anti-allergic effects, sufficient to warrant clinical trials. This is entirely concordant with other studies showing that CB 2 activation down regulates excessive inflamation being driven by innate immune responses. Thanks, John. Kofi ,kofi from anon.un, wrote in message news:kofi-59A74F.20025514062007 ...
The objective of the present work was to summarize the results of clinical studies designed to evaluate the effectiveness of Momate Rhino Advance in the form of the nasal spray (based on the fixed combination of mometasone furoate and azelastine) that finds an increasingly wide application for the treatment of allergic rhinitis. The available data give evidence that this medication can be prescribed to the patients presenting with the severe and moderate form of allergic rhinitis. The treatment should be started with the use of the combined preparation and continued, after the adequate control of the clinical symptoms of allergic rhinitis is achieved, using Momate Rhino during the next 2-4 weeks for the reliable management of the disease ...
Patient: Im 43 I have a dental cyst and sinus problems I have a horrible bleach taste in my mouth and my left nostril. Doctor: Welcome to Ask The Doctor.We are here to help you.You are suffering from Chronic Sinusitis.For a dental cyst, yo u should see your dentist and if required get it removed.Usually, an acute attack takes 5 days to settle down. But if you have persisting sinusitis, you would require to get CT Para nasal sinuses.If the CT shows slight sinus infection, then it can be treated with conservative treatment.But if the infection is severe, you would require surgery for the same.Conservative management includes:1. Steam inhalation 4-6 times a day.2. To take anti allergic like Levocetrizine3. In cases, who dont respond to anti-allergic drugs, Fluticasone Nasal spray.4. Shirt course of antibiotics like Amoxycillin and Clarithromycin.Share my opinion with your Doctor before acting upon it.I hope it helps.Stay Healthy. ...
Olopatadine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of itching or watery eyes. Olopatadine ophthalmic (for the eye) is used to treat itching, burning, redness, watering, and other eye symptoms caused by allergic conditions. Olopatadine ophthalmic may...
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Consumer information about the medication OLOPATADINE - OPHTHALMIC SOLUTION (Pataday, Patanol), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug OLOPATADINE - OPHTHALMIC SOLUTION.
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ACT Olopatadine: Olopatadine belongs to the family of medications called antihistamines. It is used to relieve signs and symptoms of allergic conjunctivitis (an allergic reaction affecting the eyes), such as itchy eyes, red eyes, and swelling of the surface of the eye.
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BioAssay record AID 183478 submitted by ChEMBL: Inhibition of passive cutaneous anaphylaxis following 3 mg/kg p.o. administration..
... - - Allergy - Expiration date: 03/2019 The composition and form of issue: Tablets, film-coated. 1 tablet contains:Fexofenadine hydrochloride 120 or 180 mg
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In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Children Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of olopatadine eye drops in children. However, safety and efficacy of olopatadine ophthalmic solution and Patanol® have not been established in children younger than 3 years of age, and of Pataday™ and Pazeo™ have not been established in children younger than 2 years of age. Older adults Appropriate studies performed to date ...
Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocort ...
In the case of compositions 2,3 and 5, which contained 0.1 tol% w/w of hydroxypropylmethylcellulose 2910, the ciclesonide concentrations in the emulsification tank immediately after homomixer processing were uniform, and the recovery rates were almostl00%. In addition, in the case of compositions 1 and 4, which contained 0.01% w/w of hydroxypropylmethylcellulose 2910, although the ciclesonide concentrations in the emulsification tank immediately after homomixer processing were somewhat nonuniform, the recovery rates were almostl00%. In contrast, in the case of composition 6, which contained 0.1% w/w of Polysorbate 80, the ciclesonide concentration in the upper portion of the emulsification tank immediately after homomixer processing was more than30% higher than in the lower portion. In addition, the recovery rate decreased by about20%. In -the case of composition 7, which contained 0.1% w/w of sorbitan trioleate, the ciclesonide concentration in the upper portion of the emulsification tank ...
Loxatomide (noto anche con la sigla R35443, durante la fase degli studi sperimentali) è un farmaco antistaminico di prima generazione appartenente alla classe della fenilpiperazina. Il farmaco possiede una attività di tipo antiserotoninergico. Loxatomide è un derivato piperazinico antagonista dei recettori H1 dellistamina. Il farmaco sembra anche possedere attività stabilizzante i mastociti attraverso inibizione del rilascio intracellulare del calcio e del release di sostanze bioattive dai mastociti. Non presenta attività antimuscarinica. Dopo somministrazione orale loxatomide viene ben assorbita dal tratto gastrointestinale e il picco di concentrazione plasmatica viene ottenuto 4 ore dopo la somministrazione orale. Il farmaco si lega per il 90% alle proteine plasmatiche e la sua emivita di eliminazione risulta di 20-30 ore. Loxatomide viene ampiamente metabolizzata per N-dealchilazione ossidativa, glucurono-coniugazione ed idrossilazione aromatica. Viene escreta sia nelle urine che ...
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Telfast (Fexofenadine 120mg) contains the active ingredient fexofenadine hydrochloride which is an antihistamine. It is suitable for adolescents over the age of
Global Perennial Allergic Rhinitis Market - World Perennial Allergic Rhinitis Market Size, Trends, Analysis And Segment Forecasts To 2020 - Perennial Allergic Rhinitis Industry Research, Outlook, Application, Product, Share, Growth, Key Opportunities, Dynamics, Analysis, Perennial Allergic Rhinitis Report - Grand View Research, Inc.
The market of perennial allergic rhinitis is segmented on the basis of drugs classes used for the treatment, such as, steroids, antihistamines, allergen immunotherapy formulations, decongestants, and other complimentary treatments.The market of perennial allergic rhinitis is expected to show steady growth during the forecast period 2014 - 2020.
This is a randomized, double-blind, placebo-controlled, 3-arm parallel-group comparative study to confirm the superiority of TAU-284 over placebo after two weeks of administration of TAU-284 (10 mg/day or 20 mg/day) or placebo to pediatric patients with perennial allergic rhinitis, with the change from baseline in total nasal symptom score (total score for the three major nasal symptoms [sneezing, rhinorrhea, and nasal congestion]) as the primary endpoint; and to investigate the dose response, safety, and plasma concentrations of TAU-284 ...
The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE ...
TY - JOUR. T1 - Effect of loratadine on histamine release induced by antigen-antibody reaction. AU - Kamei, Chiaki. AU - Sugimoto, Yukio. AU - Yamaji, Masako. AU - Takada, Miho. PY - 1996. Y1 - 1996. N2 - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of loratadine. Moreover, in ex vivo experiments, loratadine (5 mg/kg, p.o.) as well as terfenadine provided a relatively potent inhibitory effect on histamine release from lung pieces of actively sensitized guinea pigs exposed to antigen.. AB - Loratadine caused an inhibition of histamine release from rat peritoneal mast culls induced by passively sensitized mast cells, and IC 50 was 9.57 μM. SCH 34117, a metabolite of loratadine, also inhibited histamine release from mast cells, and its potency was more than that of ...
Japanese cedar pollinosis collectively refers to an allergic disease caused by Japanese cedar pollen. Patients with Japanese cedar pollinosis primarily have allergic rhinitis and allergic conjunctivitis. Patients develop sneezing and nasal discharge immediately after Japanese cedar pollens enter their nose, and have nasal occlusion after a while. Also, when Japanese cedar pollens enter their eyes, they have itchy, runny and bloodshot eyes. When the symptoms are strong, antigen components of pollens not absorbed in the nose may flow from the nose to the throat, causing itchiness of the throat and coughing. Further, symptoms such as headache due to nasal occlusion, slight fever due to inflammatory reactions in the nose and the throat, and dullness may occur ...
TY - JOUR. T1 - A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo. T2 - Suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects. AU - Grant, Andrew J.. AU - Riethuisen, Jean Michel. AU - Moulaert, Béatrice. AU - DeVos, Christine. PY - 2002. Y1 - 2002. N2 - Background: Levocetirizine is the active enantiomer of cetirizine, a potent drug with little metabolism widely used for allergic rhinitis and urticaria. Objective: This study compares the potency, consistency, onset, and duration of action of levocetirizine with other popular antihistamines. Methods: Levocetirizine 5 mg, ebastine 10 mg, fexofenadine 180 mg, loratadine 10 mg, mizolastine 10 mg, or placebo in single doses were given to 18 healthy male volunteers in a double-blind, crossover, randomized fashion. Wheal-and-flare responses to epicutaneous histamine dihydrochloride (100 mg/mL) challenge were ...

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Suppression of Matrix Metalloproteinase Production in Nasal Fibroblasts by Tranilast, an Antiallergic Agent, In VitroSuppression of Matrix Metalloproteinase Production in Nasal Fibroblasts by Tranilast, an Antiallergic Agent, In Vitro

Nasal fibroblasts (NF) were established from nasal polyp tissues taken from patients with allergic rhinitis. NF (2. ×. 10. 5. ... Suppression of Matrix Metalloproteinase Production in Nasal Fibroblasts by Tranilast, an Antiallergic Agent, In Vitro. ... from NF induced by inflammatory stimulation may underlie the therapeutic mode of action of the agent in patients with allergic ... Allergic rhinitis is an inflammatory disease characterized by nasal wall remodeling with intense infiltration of eosinophils ...
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Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also ... Numerous antihistamic agents have heretofore been known as therapeutic agents for such allergic diseases, namely, antiallergic ... The compound (1) is, therefore, useful as an antiallergic agent. An antiallergic agent comprising the compound (1) is therefore ... Antiallergic agents containing one of the compounds (1) according to this invention or a salt thereof can be formulated into ...
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Specificity of 48 hour passive cutaneous anaphylaxis reactions (PAC) in rats and mice for the analysis of antiallergic agents<...Specificity of 48 hour passive cutaneous anaphylaxis reactions (PAC) in rats and mice for the analysis of antiallergic agents<...

Specificity of 48 hour passive cutaneous anaphylaxis reactions (PAC) in rats and mice for the analysis of antiallergic agents. ... Specificity of 48 hour passive cutaneous anaphylaxis reactions (PAC) in rats and mice for the analysis of antiallergic agents. ... in rats and mice for the analysis of antiallergic agents, The Journal of Allergy and Clinical Immunology, vol. 53, no. 2, pp. ... in rats and mice for the analysis of antiallergic agents. The Journal of Allergy and Clinical Immunology, 53(2), 66. ...
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Anti-Inflammatory Agents. Glucocorticoids. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. Physiological ... Use of anti-histamines while participating in the study will not be permitted unless the subject meets criteria for anti- ... Additionally, the subject must remain on a stable dose of anti-histamine throughout the study period. If a patient meets such ... Use within four weeks from Baseline any systemic anti‐inflammatory medication, which may influence study outcome, such as ...
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  • This medication is an anti-allergic and anti-inflammatory agent, prescribed for aphthous ulcers or canker sores in people with normal immune systems. (medindia.net)
  • extract of Centella asiatica administered orally was examined for anti-pruritic study and chlorpheniramine maleate was used as standard drug while carageenan paw induced inflammatory method was used for the antiinfammatory study. (who.int)
  • The clinical importance of eosinophils in asthma has been shown by the observation of frequent exacerbation in patients with high sputum eosinophil counts and a corresponding decrease in exacerbations when anti-inflammatory therapy was adjusted to maintain low sputum eosinophil percentages. (nih.gov)
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  • 1. Antiallergic agent comprising as active ingredient a lactic acid bacterium selected from the group consisting of lactic acid bacteria species Lactobacillus acidophilus, lactic acid bacteria of the species Lactobacillus fermentum, and combinations thereof. (google.com)