A plant family of the order Geraniales, subclass Rosidae, class Magnoliopsida.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The characteristic three-dimensional shape of a molecule.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A class of organic compounds which contain two rings that share a pair of bridgehead carbon atoms.
Antibodies produced by a single clone of cells.
Pairing of purine and pyrimidine bases by HYDROGEN BONDING in double-stranded DNA or RNA.
A plant genus of the family FABACEAE. Some Pachyrhizus have been reclassified to PUERARIA. Do not confuse with yam (IPOMOEA; or DIOSCOREA) or African yam bean (SPHENOSTYLIS).
A nucleoside consisting of the base guanine and the sugar deoxyribose.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Cytosine nucleotides which contain deoxyribose as the sugar moiety.
A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Adenine nucleotides which contain deoxyribose as the sugar moiety.
A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules. (Dorland, 28th ed)
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.
A purine base and a fundamental unit of ADENINE NUCLEOTIDES.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A species of thermoacidophilic ARCHAEA in the family Sulfolobaceae, found in volcanic areas where the temperature is about 80 degrees C and SULFUR is present.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Use of plants or herbs to treat diseases or to alleviate pain.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
Adenosine molecules which can be substituted in any position, but are lacking one hydroxyl group in the ribose part of the molecule.
Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Antibodies to the HEPATITIS C ANTIGENS including antibodies to envelope, core, and non-structural proteins.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157)
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Stable elementary particles having the smallest known positive charge, found in the nuclei of all elements. The proton mass is less than that of a neutron. A proton is the nucleus of the light hydrogen atom, i.e., the hydrogen ion.
A DNA repair enzyme that catalyzes DNA synthesis during base excision DNA repair. EC
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A group of compounds which consist of a nucleotide molecule to which an additional nucleoside is attached through the phosphate molecule(s). The nucleotide can contain any number of phosphates.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Rhodopsins found in the PURPLE MEMBRANE of halophilic archaea such as HALOBACTERIUM HALOBIUM. Bacteriorhodopsins function as an energy transducers, converting light energy into electrochemical energy via PROTON PUMPS.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
The structure of one molecule that imitates or simulates the structure of a different molecule.
Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
The rate dynamics in chemical or physical systems.
Analysis of the intensity of Raman scattering of monochromatic light as a function of frequency of the scattered light.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
A cell line derived from cultured tumor cells.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Substances that reduce or suppress INFLAMMATION.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Elements of limited time intervals, contributing to particular results or situations.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
DNA-dependent DNA polymerases found in bacteria, animal and plant cells. During the replication process, these enzymes catalyze the addition of deoxyribonucleotide residues to the end of a DNA strand in the presence of DNA as template-primer. They also possess exonuclease activity and therefore function in DNA repair.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
An encapsulated lymphatic organ through which venous blood filters.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
Proteins prepared by recombinant DNA technology.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The sum of the weight of all the atoms in a molecule.
Computer-based representation of physical systems and phenomena such as chemical processes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast. (1/477)

BACKGROUND: Inflammatory and immunological responses of vascular cells have been shown to play a significant role in the progression of atheromatous formation. Tranilast [N-(3,4-dimethoxycinnamoyl) anthranillic acid] inhibits release of cytokines and chemical mediators from various cells, including macrophages, leading to suppression of inflammatory and immunological responses. This study tested whether tranilast may suppress atheromatous formation in Watanabe heritable hyperlipidemic (WHHL) rabbits. METHODS AND RESULTS: WHHL rabbits (2 months old) were given either 300 mg x kg-1 x d-1 of tranilast (Tranilast, n=12) or vehicle (Control, n=13) PO for 6 months. Tranilast treatment was found to suppress the aortic area covered with plaque. Immunohistochemical analysis showed that there was no difference in the percentage of the RAM11-positive macrophage area and the frequency of CD5-positive cells (T cells) in intimal plaques between Tranilast and Control. Major histocompatibility complex (MHC) class II expression in macrophages and interleukin-2 (IL-2) receptor expression in T cells, as markers of the immunological activation in these cells, was suppressed in atheromatous plaque by tranilast treatment. Flow cytometry analysis of isolated human and rabbit peripheral blood mononuclear cells showed that an increase in expression both of MHC class II antigen on monocytes by incubation with interferon-gamma and of IL-2 receptor on T cells by IL-2 was suppressed by the combined incubation with tranilast. CONCLUSIONS: The results indicate that tranilast suppresses atherosclerotic development partly through direct inhibition of immunological activation of monocytes/macrophages and T cells in the atheromatous plaque.  (+info)

Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery. (2/477)

BACKGROUND: Activation of vascular chymase plays a major role in myointimal hypertrophy after vascular injury by augmenting the production of angiotensin (ANG) II. Because chymase is synthesized mainly in mast cells, we assumed that the chymase-dependent ANG II formation could be downregulated by tranilast, a mast cell-stabilizing antiallergic agent. We have assessed inhibitory effects of tranilast on neointima formation after balloon injury in the carotid artery of dogs, which share a similar ANG II-forming chymase with humans, and further explored the pathophysiological significance of vascular chymase. METHODS AND RESULTS: Either tranilast (50 mg/kg BID) or vehicle was orally administered to beagles for 2 weeks before and 4 weeks after balloon injury. Four weeks after the injury, remarkable neointima was formed in the carotid arteries of vehicle-treated dogs. Chymase mRNA levels and chymaselike activity of vehicle-treated injured arteries were increased 10.2- and 4.8-fold, respectively, those of uninjured arteries. Angiotensin-converting enzyme (ACE) activity was slightly increased in the injured arteries, whereas ACE mRNA levels were not. Tranilast treatment completely prevented the increase in chymaselike activity, reduced the chymase mRNA levels by 43%, and decreased the carotid intima/media ratio by 63%. In vehicle-treated injured arteries, mast cell count in the adventitia showed a great increase, which was completely prevented by the tranilast treatment. Vascular ACE activity and mRNA levels were unaffected by tranilast. CONCLUSIONS: Tranilast suppressed chymase gene expression, which was specifically activated in the injured arteries, and prevented neointima formation. Suppression of the chymase-dependent ANG II-forming pathway may contribute to the beneficial effects of tranilast.  (+info)

Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. (3/477)

To investigate the roles of calcium-binding proteins in degranulation, we used three anti-allergic drugs, amlexanox, cromolyn and tranilast, which inhibit IgE-mediated degranulation of mast cells, as molecular probes in affinity chromatography. All of these drugs, which have different structures but similar function, scarcely bound to calmodulin in bovine lung extract, but bound to the same kinds of calcium-binding proteins, such as the 10-kDa proteins isolated in this study, calcyphosine and annexins I-V. The 10-kDa proteins obtained on three drug-coupled resins and on phenyl-Sepharose were analysed by reversed-phase HPLC. It was found that two characteristic 10-kDa proteins, one polar and one less polar, were bound with all three drugs, although S100A2 (S100L), of the S100 family, was bound with phenyl-Sepharose. The cDNA and deduced amino acid sequence proved our major polar protein to be identical with the calcium-binding protein in bovine amniotic fluid (CAAF1, S100A12). The cDNA and deduced amino acid sequence of the less-polar protein shared 95% homology with human and mouse S100A13. In addition, it was demonstrated that the native S100A12 and recombinant S100A12 and S100A13 bind to immobilized amlexanox. On the basis of these findings, we speculate that the three anti-allergic drugs might inhibit degranulation by binding with S100A12 and S100A13.  (+info)

Ketotifen and cardiovascular effects of xamoterol following single and chronic dosing in healthy volunteers. (4/477)

AIMS: To study whether desensitization occurs after long-term administration of the 1-adrenoceptor partial agonist xamoterol and, if so, whether this can be influenced by ketotifen. METHODS: In a double-blind, randomized design 10 young, healthy males received ketotifen (2 x 1 mg day(-1) p.o.) or placebo for 3 weeks with xamoterol (2 x 200 mg day(-1) p.o.) administered concomitantly during the last 2 weeks. 'l1-adrenoceptor mediated responses were assessed as exercise-induced tachycardia and isoprenaline-induced shortening of heart rate corrected electromechanical systole (QS2c); isoprenaline-induced tachycardia was measured as a mixed beta1-/beta2-adrenoceptor-mediated effect. RESULTS: The first dose of xamoterol significantly increased resting heart rate and systolic blood pressure and significantly shortened QS2c. The last dose of xamoterol after 2 weeks of treatment still produced the same responses. Ketotifen did not influence these effects of xamoterol on resting haemodynamics. The first dose of xamoterol caused a rightward shift of the exercise- and isoprenaline-induced tachycardia (mean dose ratios+/-s.e.mean: 1.20+/-0.05 and 2.46+/-0.23) and the isoprenaline-evoked shortening of QS2c (dose ratio 3.59+/-0.68). This rightward shift was even more pronounced after 2 weeks xamoterol treatment. This additional rightward shift after 2 weeks of xamoterol was not affected by ketotifen (mean difference (95% CI) of log transformed dose ratios between placebo and ketotifen: exercise tachycardia 0.001 (-0.03; 0.04); isoprenaline tachycardia 0.03 (-0.15; 0.21); isoprenaline induced shortening of QS2c 0.13 (-0.22; 0.48)). CONCLUSIONS: In humans xamoterol is a partial beta1-adrenoceptor agonist with positive chrono- and inotropic effects at rest and antagonistic properties under conditions of beta-adrenoceptor stimulation. These effects were well maintained after chronic dosing with no signs of beta1-adrenoceptor desensitization. Ketotifen does not change the beta-adrenoceptor mediated responses of xamoterol after chronic dosing.  (+info)

Comparison of intranasal triamcinolone acetonide with oral loratadine in the treatment of seasonal ragweed-induced allergic rhinitis. (5/477)

A double-blind, randomized, multicenter, parallel-group controlled study compared the efficacy and safety of intranasal triamcinolone acetonide (220 micrograms/day) and oral loratadine (10 mg/day) in patients with at least two seasons of ragweed-induced seasonal allergic rhinitis. A 28-day screening period, including a 5-day baseline period, preceded a 4-week treatment period. Reduction in rhinitis symptom scores was evident in both groups as early as day 1, with no significant between-group differences during week 1. At weeks 2, 3, and 4, patients treated with triamcinolone acetonide were significantly (P < 0.05) more improved in total nasal score, nasal itch, nasal stuffiness, and sneezing than were patients treated with loratadine. At weeks 3 and 4, rhinorrhea and ocular symptoms were significantly (P < 0.05) more improved from baseline among triamcinolone acetonide patients compared with loratadine patients. There was no significant between-group difference in relief from postnasal drip at any time point. Physicians' global evaluations significantly (P = 0.002) favored triamcinolone acetonide at the final visit, with moderate to complete relief of symptoms attained by 68% of triamcinolone acetonide patients and 59% of loratadine patients. Over the 4-week treatment period, triamcinolone acetonide patients had significantly greater improvement in total nasal score, nasal itch, nasal stuffiness, sneezing, and ocular symptoms. Both treatments were well tolerated, with headache being the most frequently reported drug-related adverse effect in both the triamcinolone acetonide (15%) and loratadine (11%) groups. These results indicate that triamcinolone acetonide is more effective than oral loratadine in relieving the symptoms of ragweed-induced seasonal allergic rhinitis.  (+info)

Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. (6/477)

Asthma is an inflammatory disease of the airways that is induced by Th2 cytokines and inhibited by Th1 cytokines. Despite a steady increase in the incidence, morbidity, and mortality from asthma, no current treatment can reduce or prevent asthma for a prolonged period. We examined the ability of unmethylated CpG oligodeoxynucleotides (ODN), which are potent inducers of Th1 cytokines, to prevent the inflammatory and physiological manifestations of asthma in mice sensitized to ragweed allergen. Administration of CpG ODN 48 h before allergen challenge increased the ratio of IFN-gamma to IL-4 secreting cells, diminished allergen-induced eosinophil recruitment, and decreased the number of ragweed allergen-specific IgE-producing cells. These effects of CpG ODN were sustained for at least 6 wk after its administration. Furthermore, there was a vigorous Th1 memory response to the recall Ag, inhibition of peribronchial and perivascular lung inflammation, and inhibition of bronchial hyperresponsiveness 6 wk after administration of CpG ODN. Administration of CpG ODN in IFN-gamma -/- mice failed to inhibit eosinophil recruitment, indicating a critical role of IFN-gamma in mediating these effects. This is the first report of a treatment that inhibits allergic lung inflammation in presensitized animals for a prolonged period and thus has relevance to the development of an effective long term treatment for asthma.  (+info)

Adhesive explant culture of allergic nasal mucosa: effect of emedastine difumarate, an anti-allergic drug. (7/477)

Allergic reaction of the nose comprises of an immediate and a late reaction. To evaluate nasal allergic reactions, many experiments have been performed by investigators. In this study, we performed a new tissue culture technique (adhesive explant culture) to analyze the migration of cells into the culture medium from the cultured allergic nasal mucosa in response to an allergen. Basophilic cells (mast cells and basophils) and eosinophils, which were released into the culture medium after the allergen challenge, were evaluated by the analysis of histamine and eosinophil cationic protein (ECP) content in the culture medium. Histamine and basophilic cells in the culture medium were more abundant in the immediate phase (within 30 min) after challenge than in the late phase (from 30 min to 10 hr). On the other hand, ECP and eosinophils in the culture medium were more abundant in the late phase than in the immediate phase. The increase of histamine content in both phases were not inhibited by pre-treatment of emedastine difumarate (EME), an anti-allergic drug. However, the increase of ECP in the late phase was inhibited by pre-treatment with EME. Moreover, the number of EG2-positive cells was also decreased by pre-treatment with EME. These results suggest that EME might lower the activation of eosinophils in the late phase of the allergic reaction. The present study also indicates that this adhesive explant culture system is useful model for studying the cellular allergic responses to drugs ex vivo.  (+info)

Effect of an orally active Th1/Th2 balance modulator, M50367, on IgE production, eosinophilia, and airway hyperresponsiveness in mice. (8/477)

We have found a novel anti-allergic agent, M50367, which suppresses IgE biosynthesis and eosinophil accumulation in vivo. In this study, we evaluated the ability of M50367 to modulate Th1/Th2 balance in Th2-background BALB/c mice and to inhibit airway hyperresponsiveness in a murine model of atopic asthma. Oral M50367 at 3-30 mg/kg/day exhibited 51 to 73% reduction of IL-4/IL-5 production and 2- to 5-fold augmentation of IFN-gamma production by Ag-stimulated cultured splenocytes of the mice sensitized with DNP-Ascaris. These alterations in Th1/Th2 cytokine production were accompanied by 55-85% suppression of plasma IgE level. Oral M50367 at a dose of 10 mg/kg/day significantly inhibited Ig-independent peritoneal eosinophilia by 54%, which was induced by repeated i.p. injections of Ascaris suum extract. To develop airway hyperresponsiveness caused by allergic airway inflammation, BALB/c mice were sensitized with i.p. OVA injections, followed three times by OVA inhalation. Oral M50367 significantly inhibited the increase in airway reactivity to acetylcholine, together with the elevation of plasma IgE level and pulmonary eosinophilia, which were observed in vehicle-treated mice 1 day after the last inhalation. Moreover, M50367 treatment reduced IL-4 and IL-5 production and tended to enhance IFN-gamma production, not only by cultured splenocytes, but also in bronchoalveolar lavage fluid. These results suggest that M50367 has a modulating ability of Th1/Th2 balance to down-regulate Th2 response in the circulating system as well as at the sites of inflammation, and may be beneficial for the treatment of allergic disorders such as atopic asthma.  (+info)

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The anti-inflammatory/antiallergic activity of a novel second-generation p38 mitogen-activated protein kinase inhibitor, SB 239063 [trans-1-(4-hydroxycyclohexyl)-4-(4-fluorophenyl)-5-(2-methoxypyridimidin-4-yl)imidazole], was investigated in vivo and in vitro. SB 239063 had an IC50 of 44 nM for inhibition of recombinant purified human p38α. In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-α production (IC50 values = 0.12 and 0.35 μM, respectively). A role for p38 kinase in cytokine-associated inflammation in the mouse was shown by p38 activation in the lung and inhibition of lipopolysaccharide-induced tumor necrosis factor-α production by SB 239063 (ED50 = 5.8 mg/kg p.o.). Antiallergic activity was demonstrated by essential abolition (∼93% inhibition) of inhaled ovalbumin (OA)-induced airway eosinophilia by SB 239063 (12 mg/kg p.o.), measured by bronchoalveolar lavage (BAL) in OA-sensitized mice. In addition, p38 ...
Methods: Female Balb/c mice were sensitized with 200 μl 0.5% DNCB for three days. After sensitization, mice were challenged with 200 μl 1% DNCB on the same dorsal skin and also 20 μl 1% DNCB on each ear every 3 days, and orally administrated by gavage with DCE (0.6, 1.2 and 2.4 g/kg) daily from day 14 to day 29 for 16 consecutive days. At the end of experiment, the clinical scores for AD on the mice were calculated to evaluate the therapeutic effect of DCE; and serum, ears and dorsal skin of the mice were collected for mechanistic study. The anti-allergic activity of DCE was also evaluated using antigen-induced RBL-2H3 cell line. The release of selected cytokines, chemokines and β-hexosaminidase was measured to determine the anti-allergic activity of DCE. In addition, intracellular Ca2+ level, MAPKs and Lyn phosphorylations were further investigated to reveal its anti-allergic molecular mechanisms ...
Guest Editors who wish to submit an issue proposal to Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry are requested to complete the following online form. The proposal of thematic issue will then be immediately forwarded to the Editor-in-Chief/Co-Editors/Executive Editor(s) of Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry who will then inform Guest Editors with a decision about the submitted proposal.. ...
Clinical Anti-Inflammatory & Anti-Allergy Drugs publishes original research, expert reviews, drug clinical trials and thematic issues in all core areas of translational and clinical anti-inflammatory & anti-allergy drug research.
Allergies can be topical, respiratory, or digestive, and result in an immune system overreaction to a substance. This can release histamines, which cause wheezing, rashes, sneezing, vomiting, and even anaphylactic shock. People can be allergic to specific foods, plants, animals, and chemicals. Human studies are lacking, and more research is necessary on the anti-allergy potential of various herbs.. Hay fever is a seasonal allergy to pollens and fungi in the air, and can irritate the nose, throat, and eyes. ...
The anti-allergy drug FPL 52757 (Fisons Ltd. ,) 6,8-diethyl-5-hydroxy-4-oxo-4H-1-benzopyran-2-carboxylic acid produced mild and reversible hepatotoxicity in some patients during clinical trials. The purpose of this work was to elucidate the mechanism by which FPL 52757 caused hepato-toxicity. However, since further humans could not be tested the work is limited to animal models. Toxicity studies showed that the beagle dog was the only animal species of ten tested which was readily susceptible to the hepatotoxic effect of the compound. In this project hepatotoxicity could not be demonstrated in ferrets or rats in special studies designed to reduce resistance to drug-induced hepatotoxicity. Similarly, hepatic microsomal enzyme induction in dogs by pretreatment with phenobarbitone and protection against cytotoxicity by pretreatment with methionine provided no evidence for involvement of a reactive metabolite in the hepatoxicity. Work by Fisons and additional studies in this project showed that the ...
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INDICATIONS. Haridra has many medicinal properties - it is a well-known herb that helps in combating allergy effectively. It has anti-inflammatory and anti-allergic activity. It helps in faster wound healing and has blood-purifying properties. It also acts as a carminative, stomachic, appetizer and tonic.. INSTRUCTIONS. Take exactly as recommended by your Health Provider.. If you miss a dose of Haridra and you are using it regularly, use it as soon as possible. Do not use 2 doses at once.. DOSAGE. Take 1 capsule twice a day after meals.. STORAGE. Store at the room temperature away from moisture and sunlight. Keep out of reach of children.. SAFETY INFORMATION. There are no know precautions for using Haridra.. SIDE EFFECTS. Haridra isnt known to have any side effects if taken as per the prescribed dosage. ...
Adenosine potentiated anaphylactic histamine release from isolated rat mast cells in a dose-dependent manner between 10−8 and 10−5 M. Adenosine was found to be present during a normal incubation of...
Allergic disease decreases the daily quality of life of many people, and can increase the number of working days lost owing to sick leave. Associated symptoms with allergic disease depend on the origin of the disease, and can either be allergic, non-allergic and purulent, or can cause rhinitis as a result of a common cold. Treatment depends on the origin of the rhinitis. However, an antihistamine is indicated in most instances. Combination treatment includes sympathomimetic drugs (either local or systemic) and corticosteroid medication (when indicated, and in most instances, used locally). The article provides an overview of the nature and the management of allergic disease and the histamine 1 antihistamines.
A variety of anti-allergy medications are generally administered. ACEI edema appears to be an allergic reaction, but it is not mediated by mast cell degranulation; therefore, the efficacy of usually effective anti-allergy drugs such as epinephrine, antihistamines, and corticosteroids is unlikely and remains unproven. No randomized controlled blinded studies have compared these medications, probably because most physicians quickly give all three. The edema generally lasts 24-72 hours and spontaneously subsides if the ACEI is halted. Standard anti-allergy medications have not been noted to be harmful, but no current evidence recommends for or against using any of them to treat ACEI angioedema.. Angioedema of the upper airway and larynx can be life-threatening. It is an ominous finding indicative of a severe process, and often requires ICU admission. The authors suggest the early use of fiber optic examination to determine the presence and extent of laryngeal involvement, and note that no patient ...
Tranilast is is an antiallergic drug. In-vitro it reduces collagen synthesis in fibroblasts,[2] and inhibits growth of neurofibroma cells. In-vitro it inhibits the production of interleukin-6 in endothelial cells ...
Olopatadine 0.2% is a well-tolerated, safe, and effective antihistamine/mast cell stabilizer for treating mild to severe allergic conjunctivitis in children and adults.
Sujiaonori, a river alga growing in the Kochi prefecture, Japan, contains several bioactive compounds such as sulfated polysaccharides (ulvans), ω-3 fatty acids, and vitamins. Dietary intake of this alga-based supplement has been reported to increase circulatory adiponectin, a salutary hormone that is reported to be associated with healthy longevity and prevents a number of cardiovascular and metabolic disorders. This report highlights the anti-allergic and skin health enhancing effects of Sujiaonori-derived ulvan (Tosalvan) and supplement, respectively. RBL-2H3 cell line was used to investigate the anti-allergic effect of algal SP through the evaluation of β-hexosaminidase activity. Algal sulfated polysaccharides or SP (Tosalvan, Yoshino SP) were extracted from powders of dried alga samples provided by local food manufacturers. Report on the effect of daily dietary intake of Sujiaonori-based supplement on skin health is part of a four-week clinical investigation that, in comparison with a supplement
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If you struggle with allergy symptoms like a stuffy, runny nose, sneezing, irritable eyes or an itchy throat, youre not alone - around one in five people in Australian and New Zealand suffer from allergic rhinitis.[1]. ...
Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma ...
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Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to something in the environment that usually causes little or no problems to most people. These diseases include hay fever, food allergies, atopic dermatitis, allergic asthma and anaphylaxis. Symptoms may include red eyes, an itchy rash, sneezing and a runny nose, shortness of breath or swelling. Food intolerances and food poisoning are separate conditions.
While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known. We examined the effect of 70% ethanol extract of Chaga mushroom (EE) and its dichloromethane (DF) and aqueous (AF) fractions using a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and found that only EE and DF ameliorated allergy symptoms to a significant extent. The in vivo mast cell-stabilizing activity was also found only in EE and DF whereas the activities to suppress Th2 and Th17 immune responses and cOVA-specific IgE production in the small intestine were observed in all three treatment regimens, implying that inhibition of the mast cell function by lipophilic compounds was vital for the therapeutic effect ...
At recommended doses, has a pronounced anti-inflammatory, anti-edema and anti-allergic effect. Anti-inflammatory effect is realized by the interaction of the drug with the receptors glucocorticosteroids. Inhibits proliferation of mast cells, eosinophils, lymphocytes, macrophages, neutrophils, reduces the production and release of mediators of inflammation and other testosterone cypionate vs enanthate biologically active agents (including histamine, prostaglandins, leukotrienes,… ...
It has been used for many centuries as a treatment for ailments. It is also used to reduce cholesterol and blood pressure. It is believed to have anti-allergic properties, and is used as a remedy for arteriosclerosi. It also relieves spasms of the smooth muscle in the walls of the internal organs, making it valuable for gallbladder problems. Researchers have found it to be mildly antiseptic as well.. ...
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Title:Anti-inflammatory and Anti-Allergic Properties of Donkey's and Goat's Milk. VOLUME: 14 ISSUE: 1. Author(s):Felicita Jirillo and Thea Magrone. Affiliation:University of Bari, Policlinico, Piazza G. Cesare, 11-70124, Bari, Italy.. Keywords:Allergy, cow, donkey, elderly, goat, microbiota, milk.. Abstract:Nowadays, donkeys and goats milk consumption has been reevaluated for its potential benefits to human health. For example, in infants with intolerance to cows milk, donkeys milk represents a good alternative due to its chemical characteristics similar to those of human milk. On the other hand, goats milk in virtue of its higher content in short chain, medium chain, mono and polyunsaturated fatty acids than that of cows milk, is more digestible than the bovine counterpart. From an immunological point of view, donkeys milk is able to induce release of inflammatory and anti-inflammatory cytokines from normal human peripheral blood lymphomononuclear cells, thus maintaining a ...
Probiotic bacteria exert positive effects on human health. Among a wide range of health beneficial effects, the anti-allergic effect is an important one. One indication of allergic reaction is the increase in IgE level in our body. The mechanism initialized by probiotic bacteria leads to the decrease of IgE level that ultimately inhibits the allergic reactions. The present study is aimed to screen anti-allergic effect of native probiotics isolated from nectar. The probiotic bacteria were isolated from the nectar sample collected from Rangpur district of Bangladesh. The isolated probiotic bacteria were then subjected to morphological and biochemical tests. These morphological and biochemical tests allowed us to ensure that the isolated bacteria were the probiotic type. Then animal trial was conducted using these probiotic isolates. In the study, mice were used as the animal model. At the end of the trial, the blood samples isolated from different mice groups were analyzed. It has been found that, ...
TY - JOUR. T1 - Zerumbone enhances the Th1 response and ameliorates ovalbumin-induced Th2 responses and airway inflammation in mice. AU - Shieh, Ying Hua. AU - Huang, Huei Mei. AU - Wang, Ching Chiung. AU - Lee, Chen Chen. AU - Fan, Chia Kwung. AU - Lee, Yueh Lun. PY - 2015. Y1 - 2015. N2 - Zerumbone is a sesquiterpene compound isolated from the rhizome of wild ginger, Zingiber zerumbet Smith. The rhizomes of the plant are used as a spice and traditional medicine. Zerumbone was shown to possess anticarcinogenic, anti-inflammatory, and antioxidant properties. However, the antiallergic activity and the underlying mechanism of zerumbone have not been reported. Herein, we investigated the immunomodulatory effects of zerumbone on antigen-presenting dendritic cells (DCs) in vitro and its potential therapeutic effects against ovalbumin (OVA)-induced T helper 2 (Th2)-mediated asthma in mice. In the presence of zerumbone, lipopolysaccharide-activated bone marrow-derived DCs enhanced T cell proliferation ...
Reilly SM, Chiang SH, Decker SJ, et al. An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar;19(3):313-21. PMID: 23396211.. Bell J. Amlexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig. 2005;25(9):555-66. PMID: 17532700.. Landriscina M, Prudovsky I, Mouta Carreira C, et al. Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitro. J Biol Chem. 2000 Oct 20;275(42):32753-62. PMID: 10921913.. Shishibori T, Oyama Y, Matsushita O, Yet al. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family. Biochem J. 1999 Mar 15;338 ( Pt 3):583-9. PMID: 10051426.. Makino H, Saijo T, Ashida Y, et al. Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of ...
Top Quality 99% Amlexanox Cas:68302-57-8 Amlexanox English name: Amlexanox Amlexanox CAS Number: 68302-57-8 Amlexanox Molecular formula: C16H14N2O4 Amlexanox Molecular weight: 298.29 Amlexanox EINECS number: Amlexanox Related categories:...
Epinastine 0.05% eye drops are used for ocular itching associated with conjunctivitis. Order at our pharmacy and save upto $56.98.
Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population.
The present study is to investigate the effect of cornuside on mast cell-mediated allergic response, as well as its possible mechanisms of action.To test the anti-allergic effects of cornuside in vivo, local extravasation was induced by local injection of anti-dinitrophenyl immunoglobulin E (IgE) followed by intravenous antigenic challenge in passive cutaneous anaphylaxis model rats. Mast cell via ...
KIOM-MA128, a novel herbal medicine, has been reported to exert some beneficial effects on various biological events, such as atopic dermatitis, inflammation and cancer. The aim of this study is to investigate how KIOM-MA128 regulates the allergic response. We measured the activity of β-hexosaminidase and the levels of allergic mediators in the conditioned media of antigen/IgE (Ag/IgE)-activated RBL-2H3 mast cells. We examined the levels of proteins associated with both the FcεRI and arachidonate cascades. Finally, we established the passive cutaneous anaphylaxis (PCA) model in mice to confirm the anti-allergic effects of KIOM-MA128 in vivo. KIOM-MA128 dose-dependently inhibited degranulation and the production of the allergic mediators described above, with no significant cytotoxicity. In the arachidonate cascade, KIOM-MA128 significantly reduced both cytosolic phospholipase A2 (cPLA2) phosphorylation and cyclooxygenase-2 (COX-2) expression. Moreover, in the FcεRI cascade, KIOM-MA128 not only
Phenergan contains the medicine promethazine, and is used to treat a wide range of symptoms ranging from combat allergic symptoms to being used as a sleep aid. Predator Nutrition
Quercetin is a naturally occuring flavonoid. Quercetin has antioxidant, antiviral and anti-allergy effects. The antioxidant effect is attributed to the cathechol-B-ring and the location of the hydroxyl substitutions. Quercetin has demonstrated activity against some viruses. This is attributed to quercetins ability to reduce the infectivity of viruses and blocking viral replication. Quercetin has also been shown to have a positive effect on the human immune system. Possibly by increasing neutrophil chemotaxis, macrophage phagocytosis, natural killer cell lytic activity, and mitogen-stimulated lymphocyte proliferation. Quercetin has also been shown to have anti-allergy effects attributed to the fact that it may affect mast cell proliferation and secretory granule development.. ...
Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric illnesses. The incidence of obesity among populations in both the developing and the developed world has reached epidemic proportions. In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from activities focused on raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. Anti-obesity Drug Discovery and Development is a book series focused on this very important area of healthcare research. Each volume presents insightful updates on pharmaceutical research and development for clinical researchers and healthcare professionals involved in obesity treatment programs.. The fourth volume of this series covers 6 reviews on anti-obesity treatment strategies including updates on obesity and cancer ...
Oxatomide IUPAC nomenclature 1-{3-[4-(diphenylmethyl)piperazin-1-yl]propyl}-1,3-dihydro-2H-benzimidazol-2-one Classification H1-receptor antihistamine Piperazine antihistamine Physiochemical Properties S. NO. PHYSICAL AND CHEMICAL PROPERTIES 1 Molecular weight 426.6 g/mol 2 Physical appearance N/A 3 Melting point 153.6oC 4 Solubility N/A 5 Octanol/water partition coefficient N/A 5 […]. ...
NaturalNews) Spirulina is considered one of natures most perfect foods because it performs such a broad spectrum of activities in the body. Its nutritional profile shows it can replace many more expensive supplements, and its research profile reveals its dedication to promoting good health. Several animal studies have documented the ability of spirulina to arrest the development of cancer progression, reduce risk of cancer initiation, and boost the immune system. Spirulina has anti-viral and anti-allergic effects, and is a natural antihistamine. Recently, spirulina has been found effective at lowering the immune response when it has become overactive, a function that may make it effective against autoimmune diseases such as multiple sclerosis.. Spirulinas credentials date back more than three billion years. Spirulina are microscopic coiled blue-green algae that have been around for the past 3.6 billion years or so. Spirulina and other blue-green algae were the generators of the oxygen found in ...
Prednisolone is a hormone drug which provides an action to most functions of the body. It shows an anti-inflammatory, and anti-allergic action. Buy Prednisolone online.
Bacopa is a great tranquilizing, memory and learning enhancing, cerebral activator, anti-ulcer, neurotonic, immuno-modulator, adaptogen,antispasmodic, anti-asthmatic ayurvedic herb. Other benefits are anti-allergic action, and free radicals scavenging effect as herbal supplement in Epilepsy, anxiety and depression. Know its beneficial actions on brain, learning skills, anxiety, depression, stress, epileps memory, mental deficiency, Alzheimers disease,and ADHD children. http://www.holistic-herbalist.com/bacopa.html ...
What is Cortisol?. Cortisol is a steroid and a stress hormone. Production of cortisol is stimulated when stress is triggered. Cortisol plays an important role in the different metabolic processes in the body. Through its increased distribution in stress situations, it is able to provide energy by consuming sugar, fat and protein reserves. By immune processes cortisol also helps with its anti-inflammatory and anti-allergic effect, and has an important function in maintaining the health of the body.. Excessively low cortisol levels. It is well known that chronic stress is unhealthy - and stress is in turn the most important impulse that causes the increase of the distribution of cortisol. If the cortisol levels are too high, symptoms can include immunodeficiencies, depression, physical exhaustion, metabolic disorders, diabetes, obesity and sleeping disorders. Excessively high cortisol levels can indeed cause unpleasant symptoms.. Just the same, excessively low cortisol levels can interfere with ...
The risk of hyponatremia is not particularly high. Beware more of dehydration than hyponatremia. Nevertheless, you should not drink constantly. Its a good idea to have a drink at the pace of the drink points on the marathon route.. If a beginner runs the marathon very slowly, there is less heat in the body and less fluid is consumed. If you always drink a couple of cups at resting places and then drink some extra of your own drinks just in case, you may have too much fluid load.. When sweating on a hot day, also non-fitness enthusiasts should take care of hydration properly. And beware, you need to be careful with alcohol, as it drains your body.. Excess weight and several drugs may increase the symptoms of heat. These include, for example, anti-allergic drugs, beta-blockers, antidotes, and de-icing agents. Avoid taking any drugs like aspirin, ibuprofen and naproxen (NSAIDS) before or during a race if at all possible. These drugs increase the risk for exercise-associated hyponatremia and acute ...
Alan G. Kabat, OD, discusses why olopatadine 0.2% is his preferred anti-allergy medication for managing mild-to-moderate seasonal allergic conjunctivitis.
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Consultant Immunologist at Epsom and St Helier, Dr Grant Hayman said: The symptoms of hay fever can be unpleasant, but are quite common. There are a number of things you can do to help lessen the symptoms, such as wearing wraparound glasses to keep pollen out of your eyes, drying bed linen indoors during the pollen season and keeping the windows closed if at all possible.. If you are feeling very uncomfortable then I would recommend speaking to your pharmacist. They can give advice and suggest the best treatments, like antihistamine tablets, anti-allergy eye drops and/or steroid nasal sprays. If your symptoms get worse or do not get better after taking medication from your local pharmacist, get in touch with your GP.. For hay fever sufferers who also have asthma, the symptoms can be more severe and can often lead to tightness in the chest, shortness of breath and wheezing and coughing. If you have asthma, make sure you carry your reliever inhaler and know what to do if your symptoms get ...
Antiallergic medications are used to inhibit hypersensitivity in the allergy-predisposed individuals. They are blocking histamine receptors, responsible for allergic response development.
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Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: R1 is hydrogen, C1-6 alkyl or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydroxy, nitro, cyano, C2-10 acyloxy, NR6 R7 wherein R6 and R7 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl; or COR8 wherein R8 is hydroxy, C1-6 alkoxy or NR9 R10 wherein R9 and R10 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen, halogen, CF3, C1-4 alkoxy, C1-4 alkyl or any of the groups listed for R3 ; and R5 is hydrogen, C1-4 alkyl or benzyl optionally substituted in the phenyl ring by halogen, CF3, C1-4 alkoxy or C1-4 alkyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory and/or anti-allergy activity, and their use as pharmaceuticals.
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It shut out pollen and the fine particles of the exhaust gas and is effective in an anti-allergy measure.. * There is not it in the genuine disposable item, and recycling is possible. ...
A selected ion monitoring method for the estimation of an anti-allergy compound isamaxole (N-butyl-N-(4-methyloxazol-2-yl)-2-methylpropanamide, LRCL 3950) in plasma has been developed. The method uses a stable analogue containing nine deuterium atoms
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Ciclesonide is a corticosteroid. It prevents the release of substances in the body that cause inflammation. Ciclesonide is used to prevent asthma attacks in adults and children who are at least 12 years. Ciclesonide may also be used for purposes not listed in this medication guide.
The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment ...
Local treatment of antiseptic and anti-allergic rhinitis NASAL WAY Adult: 1 spray in each nostril 4 to 6 times a day. Child: 1 spray in each nostril 2 to 3 times a day. Infant: 1. Spraying in each nostril 1 to 2 times a day. The nasal sprays are done with the bottle in a vertical position.
Ceasing exposure to known allergens is the first step in anti-allergic treatment. Disposing of the allergen isnt constantly conceivable, as on account of dust sensitivities. Pharmaceuticals Different medications can alleviate the symptoms of rhinitis. Some are taken orally, others are nasal showers or eye drops (eye drops). On the off chance that over-the-counter items dont […]. ...
Ze Xie is also known as Alisma. The sweet, bland and cold herb has been used in TCM as anti-pyretic , as anti-bacterial, hypoglycemic, hypotensive, anti tumor, anti-allergic, etc., as it eliminates water, clear Heat, diuretic, etc., by enchaining the functions of bladder and kidney channels. Ingredients 1. Alisol A、B、C 2. Alosol A monoacetate 3. …. ...
It was my first on-line order! I always scared to lost money, to receive bad-quality product or that my parcel will be lost by post. But everything was good! My parcel arrived in selected day, in perfect condition, in professional package and I am using my anti-allergic pills already 3 weeks and result is great, so quality of medicine is also good. All that remains - to say thank you ...
It was my first on-line order! I always scared to lost money, to receive bad-quality product or that my parcel will be lost by post. But everything was good! My parcel arrived in selected day, in perfect condition, in professional package and I am using my anti-allergic pills already 3 weeks and result is great, so quality of medicine is also good. All that remains - to say thank you ...
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Nelson, Wendel L. (2007). "Antihistamines and Related Antiallergic and Antiulcer Agents". In William O. Foye; Thomas L. Lemke; ... These indications may include: Allergic rhinitis Allergic conjunctivitis Allergic dermatological conditions (contact dermatitis ... helping to relieve allergic reactions. Agents where the main therapeutic effect is mediated by negative modulation of histamine ... "Allergic and Non-allergic Rhinitis". Textbook of Clinical Otolaryngology. Cham: Springer International Publishing. pp. 241-252 ...
Nelson WL (2002). "Antihistamines and related antiallergic and antiulcer agents". In Williams DH, Foye WO, Lemke TL (eds.). ... For allergic rhinitis, loratadine is indicated for both nasal and eye symptoms - sneezing, runny nose, and itchy or burning ... Canonica GW, Blaiss M (February 2011). "Antihistaminic, anti-inflammatory, and antiallergic properties of the nonsedating ... This includes allergic rhinitis (hay fever) and hives. It is also available in combination with pseudoephedrine, a decongestant ...
Anti-allergic properties of pipethiaden--a new preventive agent for migraine]". Ceskoslovenska Farmacie (in Czech). 38 (6): 264 ...
"Anti-allergic properties of pirquinozol (SQ 13,847) an orally effective agent. Evaluation in an anti-IgE-induced pulmonary ... Free CA, Hall LE (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. II. Activity in vitro". The ... Casey FB, Abboa-Offei BE, Marretta J (June 1980). "Antiallergic properties of SQ 13,847, an orally effective agent. I. Activity ... Pirquinozol (SQ-13,847) is a drug which was investigated as an antiallergen and antiasthmatic agent in the early 1980s but was ...
Anti-inflammatory agents, Leukotriene antagonists, Carboxylic acids, Isopropyl compounds). ... In Japan, it is used to treat bronchial asthma, allergic rhinitis and conjunctivitis. The drug is contraindicated in those with ... Amlexanox (trade name Aphthasol) is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers ( ... 7. Synthesis of antiallergic 5-oxo-5H-[1]benzopyrano[2,3-b]pyridines". Journal of Medicinal Chemistry. 28 (5): 559-568. doi: ...
This causes the compound to have anti-allergic properties. The condensation of 6-acetyl-7-hydroxy-1,2,3,4-tetrahydronaphthalene ... Furukawa, Clifton T. (1984). "Other pharmacologic agents that may affect bronchial hyperreactivity". Journal of Allergy and ... It suppresses allergic reactions by binding to FcεRI receptor in mast cells, thereby inhibiting production of histamines. It is ... Allergic reactions or responses to inflammation or invading microorganisms are coordinated by these cells in a process called ...
Chang TW, Wu PC, Hsu CL, Hung AF, 2007, "Anti-IgE antibodies for the treatment of IgE-mediated allergic diseases." Advances in ... Chang TW and Shiung YY, 2006, "Anti-IgE as a mast cell-stabilizing therapeutic agent." The Journal of Allergy and Clinical ... Chang is a cofounder of Tanox, a biopharmaceutical company specialized in anti-IgE therapies for the treatment of allergic ... antibodies that target the IgE-mediated allergic pathway have proven effective in the treatment of various allergic diseases. ...
They are the most common prescribed class of topical anti allergy agent. Olopatadine (Patanol, Pazeo) and ketotifen fumarate ( ... The cause of allergic conjunctivitis is an allergic reaction of the body's immune system to an allergen. Allergic ... Both seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) are two acute allergic conjunctival ... Treatment consists of antihistamine, mast cell stabilizers, dual mechanism anti-allergen agents, or topical antihistamines. ...
Naproxen is a non-steroidal anti-inflammatory drug while cromolyn is an anti-allergic agent which acts as a mast cell ... Curcumin has wide pharmacological activities: anti-inflammatory, anti-microbial, hypoglycemic, anti-oxidant, and wound healing ... Anti-obesity effects of naproxen and cromolyn: Both drugs showed significant anti-obesity effects as they reduce body weight, ... "Synthesis and exploration of novel curcumin analogues as anti-malarial agents". Bioorganic & Medicinal Chemistry. 16 (6): 2894- ...
"Inhibition of allergic inflammation by C-terminal peptides of the prohormone submandibular rat 1 (SMR-1). Int Arch Allergy ... 2001 an-Mar;124(1-3):201-4. (Anti-inflammatory agents). ... Immune Selective Anti-Inflammatory Derivatives (ImSAIDs) are a ... The ImSAIDs represent a new category of anti-inflammatory and are unrelated to steroid hormones or non steroidal anti- ... One SGP-T derivative is a three amino acid sequence shown to be a potent anti-inflammatory molecule with systemic effects. This ...
Kakiuchi M, Ohashi T, Musoh K, Kawamura K, Morikawa K, Kato H (1997). "Studies on the novel antiallergic agent HSR-609: its ... O]ral ketotifen has been used in patients with asthma, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, chronic ... In its ophthalmic form, it is used to treat allergic conjunctivitis. In its oral form, it is used to prevent asthma attacks or ... Besides its anti-histaminic activity, it is also a functional leukotriene antagonist and a phosphodiesterase inhibitor. "[ ...
Unpasteurized soy sauce is rich in lactic acid bacteria and of excellent anti-allergic potential. Soy sauce does not contain ... but it is difficult to make soy sauce without using some quantity of salt as an antimicrobial agent. A serving of 100 ... Kobayashi, Makio (18 April 2005). "Immunological Functions of Soy Sauce: Hypoallergenicity and Antiallergic Activity of Soy ...
... have also been suggested as causative agents. However, the literature is scarce and conflicting as passive infusion of anti-IgA ... The usual cause of these allergic reactions is proteins in the donor plasma. These proteins are removed by the process of ... The most common reason for using washed red blood cells in transfusion medicine is to prevent the recurrence of severe allergic ... Hirayama F (February 2013). "Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests ...
... anti-cancer[citation needed] Allergic reactions to Taxol are most often allergic reactions to Kolliphor EL; symptoms include ... intravenous anaesthetic agent, originally presented in Kolliphor EL for trials; now presented in a lipid emulsion[citation ... The allergic reaction is usually immediate and is similar to severe allergic reactions of many other substances that trigger ... Miconazole, anti-fungal[citation needed] Docetaxel, anti-cancer[citation needed] Aci-Jel (acetic acid / oxyquinoline / ...
Antileukotrienes are anti-inflammatory agents which function as leukotriene-related enzyme inhibitors (arachidonate 5- ... Dery, R.E.; Mathison, R.; Davison, J.; Befus; A.D. (2001). "Inhibition of allergic inflammation by C-terminal peptides of the ... In April 2014, plumericin from the Amazonian plant Himatanthus sucuuba has been described as a potent anti-inflammatory agent ... Many modern analgesics and anti-inflammatory agents (such as paracetamol and its predecessor phenacetin) are derived from ...
Al-Ahmad, Mona; Hassab, Mohammed; Al Ansari, Ali (21 December 2020). "Allergic and Non-allergic Rhinitis". Textbook of Clinical ... Yamatake Y, Sasagawa S, Yanaura S, Okamiya Y (1977). "Ipratropium Bromide (Sch1000) の抗アレルギー性喘息効果" [Antiallergic asthma effect ... India, smoking the herb stramonium (an anticholinergic agent related to ipratropium and tiotropium currently used in inhalers) ... Potentially serious side effects include urinary retention, worsening spasms of the airways, and a severe allergic reaction. It ...
Loperamide (Imodium AD) an anti-diarrheal agent. Pepto Bismol tablets, to settle upset stomachs, treat diarrhea, and heartburn ... Epi-pen, epinephrine in an auto injecting "pen" to counter anaphylactic (severe allergic) reactions. A combat medic is ... Hemostatic agents, such as Celox, Hemcon bandages, and others. Some hemostatic agents are controversial due to history of being ... acetaminophen (Tylenol), anti-pyretic and pain reducer. Naproxen and ibuprofen, different NSAIDs which reduce pain and ...
When used in large doses, they may cause a strong allergic reaction. The most serious of these are classified as severe ... The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. ... and the anti-retrovirals amprenavir and fosamprenavir. Other sulfonamide drugs do not contain this arylamine group; available ... A key component to the allergic response to sulfonamide antibiotics is the arylamine group at N4, found in sulfamethoxazole, ...
9 Anti-inflammatory agents". Diagnosis and Management of Asthma. ISBN 978-1-932610-38-3. Austin RJ, Maschera B, Walker A, ... People should not use mometasone topical (skin cream) if: hypersensitive or allergic to any ingredient in the skin cream ... It is believed that the action of corticosteroid anti-inflammatory agents is bound to inhibitive proteins of phospholipase A2, ... Mometasone furoate can be used with formoterol for the treatment of asthma, due to its anti-inflammatory properties. People ...
... is a drug used as an anti-inflammatory agent on the skin, as well as rectally. Common brand names include Paraderm ... It was withdrawn in Europe and Australia because of allergic reactions. Ointments and lotions containing bufexamac are used for ... Anti-inflammatory agents, Hydroxamic acids, Phenol ethers, Withdrawn drugs). ... Bufexamac is thought to act by inhibiting the enzyme cyclooxygenase, which would make it a non-steroidal anti-inflammatory drug ...
These drugs are in use and/or shown to be effective as prophylaxis and chronic treatments for allergic and non-allergic ... of patients reporting no change in symptoms after treatment with these agents. It seems possible that the responses of CysLTR2 ... diseases such as: allergen-induced asthma and rhinitis; nonsteroidal anti-inflammatory drug-induced asthma and rhinitis (see ... Liu M, Yokomizo T (2015). "The role of leukotrienes in allergic diseases". Allergology International. 64 (1): 17-26. doi: ...
... a sulfur-dioxide-related agent, or an agent whose levels in alcohol beverages correlated positively with those of sulfur ... These allergic-reaction-like symptoms, which typically occur within 30-60 minutes of ingesting alcoholic beverages, do not ... and by nonsteroidal anti-inflammatory drugs (NSAID) other than aspirin. The study suggested the salicylate-"contaminates" in ... The prevalence of ethanol-induced allergic symptoms in non-Asian genotypes commonly ranges above 5%, even though many of these ...
... provide a base for designing agents that can prevent IgE/Fc-RIa interactions and reduce allergic conditions. Argiolas, A; ... At higher concentrations, it has anti-inflammatory properties. In addition, it is a potent blocker of voltage-sensitive ... These actions of MCD peptide on mast cells is thought to be involved in allergic and inflammatory processes related to type I ... at higher concentrations it displays anti-inflammatory activities. Through its effect on ionic channels, MCD peptide can induce ...
Apigenin, a phytochemical in chamomile, may interact with anticoagulant agents and nonsteroidal anti-inflammatory drugs, while ... People who are allergic to ragweed (also in the daisy family) may be allergic to chamomile due to cross-reactivity. ... Chamomile is not recommended to be taken with aspirin or non-salicylate NSAIDs (non-steroidal anti-inflammatory drugs), as it ... Chamomile is under preliminary research for its potential anti-anxiety properties. There is no high-quality clinical evidence ...
The HAMA response is essentially an allergic reaction to the mouse antibodies that can range from a mild form, like a rash, to ... due to the preponderance of medical agents made from the serum of animals. Monoclonal antibodies can be generated for human use ... Human anti-mouse antibody or human anti-murine antibody (HAMA) is an antibody found in humans which reacts to immunoglobins ... It took considerable, sustained pressure from animal welfare groups, led by legal efforts initiated by the American Anti- ...
While much further work is needed, these studies indicate that PGF2α-FP axis has some pro-inflammatory and anti-inflammatory ... The axis may likewise play role in human allergic responses: PGF2α causes airway constriction in normal and asthmatic humans ... Eyelid hypotrichosis caused by FP receptor agonists are used as highly effective agents to synchronize the oestrus cycles of ... Claar D, Hartert TV, Peebles RS (2015). "The role of prostaglandins in allergic lung inflammation and asthma". Expert Review of ...
Anti-Inflamm Anti-Allergy Agents Med Chem. 11 (3): 230-7. doi:10.2174/1871523011202030230. PMID 23173575. Maclaren WR, Bruff WC ... and bromodiphenhydramine hydrochloride in treating allergic symptoms". Annals of Allergy. 13 (3): 307-12. PMID 14377226. Ahmadi ... Abbas; Khalili, Mohsen; Hajikhani, Ramin; Safari, Narjes; Nahri-Niknafs, Babak (2011). "Anti-inflammatory effects of two new ...
... and anti-allergic properties. List of poisonous plants Hirsch, Heidi; Wagner, Viktoria; Danihelka, Jiří; Ruprecht, Eszter; ... It has been used in the Soviet Union to treat edema or swelling and as an alternative cardiac agent. In 1879, a Russian medical ... The plant also contains some flavones with pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory ...
The mechanism of action of anti-D is not fully understood; however, after administration the anti-D coated red blood cell ... Other side effects include allergic reactions, kidney problems, and a very small risk of viral infections. In those with ITP, ... unknown infectious agents. RhIG can be administered by either intramuscular (IM) or intravenous (IV) injection, depending on ... Anti-D must be administered via the intravenous route when used in clinical situations requiring an increase in platelet count ...
This includes: Asthma Environmental allergic reaction Granulomatosis with polyangiitis Allergic bronchopulmonary aspergillosis ... Medications such as nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), nitrofurantoin, phenytoin, L-tryptophan, daptomycin ... is some suspicion that at least the acute form is the result of the body's response to some unidentified environmental agent. ... and ampicillin, and drugs of abuse such as inhaled heroin and cocaine may trigger an allergic response which results in ...
The preventive effect of indeloxazine hydrochloride to the sexual dysfunction caused by anti-androgenergic agent (allylestrenol ... Allylestrenol should not be taken by people who are allergic to ibuprofen or naproxen, or who have salicylate intolerance or a ... Yamanaka H, Kosaku N, Makino T, Shida K (September 1983). "[Fundamental and clinical study of the anti-prostatic effect of ... Iguchi H, Ikeuchi T, Kai Y, Yoshida H (March 1994). "[Influence of anti-androgen therapy for prostatic hypertrophy on lipid ...
"Anti-vaxxers stopped the last Lyme disease vaccine. The FDA has just fast-tracked a new one". Newsweek. 25 July 2017. Archived ... After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, ... because if the person is allergic, anaphylaxis could result. Instead, a product should be sprayed on the tick to cause it to ... Masuzawa T (December 2004). "Terrestrial distribution of the Lyme borreliosis agent Borrelia burgdorferi sensu lato in East ...
... sodium hypochlorite is used to remove all traces of nerve agent or blister agent from Personal Protection Equipment after an ... Nickmilder M, Carbonnelle S, Bernard A (February 2007). "House cleaning with chlorine bleach and the risks of allergic and ... Sodium hypochlorite in solution exhibits broad spectrum anti-microbial activity and is widely used in healthcare facilities in ... 50% sodium hypochlorite is also used to neutralize any accidental releases of the nerve agent in the toxic areas. Lesser ...
In general, sedating properties of anti-depressant agents are related to antagonism of serotonin 5HT2, histamines, and α-1 ... The drug was also under investigation for the treatment of allergic rhinitis, atopic dermatitis, and contact dermatitis, but ... Sympathomimetic agents may have their effects potentiated by TCAs like doxepin. Doxepin also may potentiate the adverse effects ... Antiarrhythmic agents may be an appropriate measure to treat cardiac arrhythmias resulting from doxepin overdose. Slow ...
A pest is any species, strain or biotype of plant, animal, or pathogenic agent injurious to plants or plant products. Worldwide ... "Food body production in Macaranga triloba (Euphorbiaceae): A plant investment in anti-herbivore defense via symbiotic ant ... and are linked with allergic reactions in humans. Various insects attack dry food products, with flour beetles, the drugstore ...
Possible causative agents include radiation therapy of the chest, exposure to medications used during chemo-therapy, the ... The production of anti-inflammatory proteins, and the degeneration of mRNA encoding inflammatory proteins, can also be ... "Hypersensitivity Pneumonitis (Extrinsic Allergic Alveolitis) : OSH Answers". Canadian Centre for Occupational Health and Safety ... These all share similar symptoms, but differ in causative agents. Diagnosis of pneumonitis remains challenging, but several ...
Armed DHS agents had been on standby near the Capitol in case of unrest but were not deployed until after the violence had ... The Anti-Defamation League published a January 4 warning about calls to violently disrupt the counting. The post said the ... The medical examiner found no evidence that Sicknick had an allergic reaction to the chemical spray. Prosecutors later said on ... Cohen, Li (January 7, 2021). "Photos show difference in how police responded to anti-racism protests and the siege at the U.S. ...
... s can also be removed chemically and biologically using antifungal/anti‐mycotoxins agents and antifungal plant ... So far animal models indicate that airway exposure to S. chartarum can evoke allergic sensitization, inflammation, and ... In the feed and food industry it has become common practice to add mycotoxin binding agents such as montmorillonite or ... Dimorphic fungi, which include Blastomyces dermatitidis and Paracoccidioides brasiliensis, are known causative agents of ...
The SSRI medication sertraline (Zoloft) is approved as an anti-depressant but is also commonly prescribed off-label to help men ... Doxepin has been used to treat Angiodema and severe allergic reactions due to its strong antihistamine properties. Gabapentin, ... often as an augmentation agent. Lithium is recommended for the treatment of schizophrenic disorders only after other ... Although the exact mechanism of colchicine is not fully understood, its anti-inflammatory effect for pericarditis appears to be ...
Moreover, in cases involving topical therapeutics, the role of MSM as an active agent, per se, versus its having a role in ... This is supported by in vitro research showing MSM inhibits over-activation of white blood cells and has an anti-apoptotic ... Two studies have evaluated the effects of MSM on allergic rhinitis. A 2004 multi-centered, open-label clinical trial found that ... Kim, Yoon Hee; Kim, Dae Hwan; Lim, Hwan; Baek, Doo-Yeon; Shin, Hyun-Kyung; Kim, Jin-Kyung (2009). "The anti-inflammatory ...
... anti-vaccinationists have been known as "anti-vaxxers" or "anti-vax". Vaccine hesitancy is complex and context-specific, ... The concentration of thiomersal used in vaccines as an antimicrobial agent ranges from 0.001% (1 part in 100,000) to 0.01% (1 ... As with any medical treatment, there is a potential for vaccines to cause serious complications, such as severe allergic ... The New England Anti-Compulsory Vaccination League formed in 1882, and the Anti-Vaccination League of New York City in 1885. ...
Anti-inflammatory agents, Benzofurans, Fluoroarenes, Immunosuppressants, Quinolines, Selective glucocorticoid receptor ... and allergic conjunctivitis. Preliminary investigation for the treatment of keratoconjunctivitis sicca has been conducted in ... Mapracorat (INN, code names BOL-303242-X, ZK-245186) is an anti-inflammatory drug belonging to the experimental class of ... "Mapracorat Ophthalmic Formulation in Subjects With Allergic Conjunctivitis" at ClinicalTrials.gov Clinical trial number ...
The function of GPR99 as a receptor for leukotriene E4 has been confirmed in a mouse model of allergic rhinitis. GPR17 - GPR17 ... Activation of ALX/FPR2 by the lipoxins is associated with anti-inflammatory responses by target cells and tissues. Receptors ... eicosanoids but also many other agents including the docosanoids resolvin D1, resolvin D2, and 17R-resolvin D1 (see specialized ... Claar D, Hartert TV, Peebles RS (2015). "The role of prostaglandins in allergic lung inflammation and asthma". Expert Review of ...
Generalised allergic reactions are rare; they include hives as well as swelling of lips, tongue, and throat, potentially ... it acts as a keratolytic agent and also kills bacteria, fungi, scabies mites and other parasites. Chemically, it is the ... Anti-acne preparations). ...
Agents that induce or inhibit CYP3A4 such as phenytoin, rifampin, and azole antifungals will affect the metabolism of ... Angelucci, F.; Basso, A.; Bellelli, A.; Brunori, M.; Pica Mattoccia, L.; Valle, C. (August 2007). "The anti-schistosomal drug ... Side effects in humans may include poor coordination, abdominal pain, vomiting, headache, and allergic reactions. While it may ... Agents Chemother. 41 (6): 1256-9. doi:10.1128/AAC.41.6.1256. PMC 163896. PMID 9174180. ...
Hajime Kimata (May 2004). "Reduction of allergic skin weal responses by sexual intercourse in allergic patients". Sexual and ... for measuring the degree to which human saliva is a good cleaning agent for dirty surfaces. Medical Education: Akira Horiuchi, ... for his pioneering work with anti-gas liquids that prevent bloat, gassiness, discomfort, and embarrassment. Peace - Edward ... Kimata, Hajime (November 2003). "Kissing reduces allergic skin wheal responses and plasma neurotrophin levels". Physiology & ...
At one point, FBI agents were sent to Uruguay to investigate a lead. Other agents were sent to stake out the 60th anniversary ... And we all made him vulnerable." At six years of age, Douglas died from Reye syndrome after having a severe allergic reaction ... Even after 1983, when Morris was transferred to head up the Boston FBI's anti-drug task force, he remained an accomplice to ... FBI Agent John Morris was put in charge of the Organized Crime Squad at the FBI's Boston field office in December 1977.: 54 ...
... oral anti-diabetics, colestyramine, dextromethorphan, mifepristone, corticosteroids, anti-platelet agents and selective ... or other allergic reactions caused by Aspirin or other nonsteroidal anti-inflammatory drugs (for example diclofenac, ibuprofen ... Tenoxicam, sold under the brand name Mobiflex among others, is a nonsteroidal anti-inflammatory drug (NSAID). It is used to ... "Assessment report for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and cardiovascular risk" (PDF). European Medicines Agency ...
Anti-inflammatory actions: Inflammations of the airways as in acute and chronic bronchitis, rhinosinusitis or in bronchial ... Poole P, Sathananthan K, Fortescue R (May 2019). "Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive ... "Interference of myrtol standardized with inflammatory and allergic mediators". Arzneimittel-Forschung. Editio Cantor Verlag. 48 ... ISBN 978-3-642-59770-1. Rantzsch U, Vacca G, Dück R, Gillissen A (December 2009). "Anti-inflammatory effects of Myrtol ...
... (喜炎平) is an anti-inflammatory and antiviral preparation developed and licensed for use in China. It is a semi- ... Xiyanping injection may be associated with side effects typical of allergic reaction, most commonly erythema and pruritus ... Antiinfective agent stubs). ... "Potential anti-angiogenic sulfates of andrographolide". Journal ...
Between the two treatments (Days 2-9) the person will still be infested with lice that hatch from eggs not killed by the anti- ... Agents approved by the FDA for treatment of pediculosis include abametapir, topical ivermectin lotion, lindane, malathion, ... head lice treatment recommended against the use of tea tree oil for children because it could cause skin irritation or allergic ... If living lice are still present, the treatment is repeated using an anti-louse product with a different active ingredient. ...
The agents work by prolonging the Effective Refractory Period (ERP) either by blocking sodium ions (Class I drugs) or by ... The anti-arrhythmic medications often used in either pharmacological cardioversion or in the prevention of relapse to AF alter ... or clopidogrel in those who are allergic to aspirin). In contrast, those with a high risk of stroke derive most benefit from ... Among patients with nonvalvular AF, anticoagulation with warfarin can reduce stroke by 60% while antiplatelet agents can reduce ...
Other antifolate agents such as methotrexate and trimethoprim may potentiate the antifolate actions of pyrimethamine, leading ... Common side effects include gastrointestinal upset, severe allergic reactions, and bone marrow suppression. It should not be ... it does not have intrinsic anti-parasitic activity) to treat the parasitic diseases toxoplasmosis and cystoisosporiasis. It is ... 2004). "Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum". Antimicrob Agents Chemother. 48 (6): ...
... helps remove infectious agents. Also, mucus traps infectious agents. Gut flora can prevent the colonization of pathogenic ... The motor arc of the inflammatory reflex is termed the cholinergic anti-inflammatory pathway. The parts of the innate immune ... histamine-releasing basophils are important in the defense against parasites and play a role in allergic reactions, such as ... The epithelial surfaces form a physical barrier that is impermeable to most infectious agents, acting as the first line of ...
... these metabolites are members of the specialized proresolving mediator class of anti-inflammatory agents that contribute to the ... and monocyte chemotaxis and thereby possible contributors to human allergic and non-allergic inflammation responses (see 5- ... These products may be further metabolized to: Resolvin E3, a specialized proresolvin mediator with anti-inflammatory activity ( ... These metabolites have been reported to have anti-inflammatory activity, to have vasodilationactivity, to promote pain ...
Antimicrob Agents Chemother. 2014;58(11):6668-6674. doi:10.1128/AAC.03622-14 Long SW, Olsen RJ, Mehta SC, et al. PBP2a ... If this product is to be given to penicillin- or other beta-lactam-allergic people, caution should be exercised because cross ... 2003). "TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and ... If an allergic reaction to ceftaroline occurs, the drug should be discontinued. Serious acute hypersensitivity reactions ...
When given by injection, anti-inflammatory effects begin in around two hours and last for seven days. It is used as a topical ... In some countries, it is also sold mixed with both clotrimazole and gentamicin to add an antibacterial agent to the mix. ... Serious side effects include an increased risk of infection, muscle weakness, severe allergic reactions, and psychosis. Long- ... allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby's lungs, Crohn's disease ...
Pharmacological Actions : Anti-Allergic Agents : CK(442) : AC(150), Anti-Inflammatory Agents : CK(20859) : AC(8334), ... Additional Keywords : Adlay, allergies, Anti-Allergic Agents, Anti-Inflammatory Agents, Plant Extracts : CK(14140) : AC(5210) ... Pharmacological Actions : Anti-Allergic Agents : CK(442) : AC(150), Interleukin-4 downregulation : CK(355) : AC(128), ... Pharmacological Actions : Anti-Allergic Agents : CK(442) : AC(150), Immunomodulatory : CK(4048) : AC(1475) ...
... receptor antagonists currently available for the treatment of seasonal allergic rhinitis. ... Anti-Allergic Agents / adverse effects * Anti-Allergic Agents / therapeutic use* * Cetirizine / adverse effects ... and cetirizine in seasonal allergic rhinitis J Allergy Clin Immunol. 1999 Nov;104(5):927-33. doi: 10.1016/s0091-6749(99)70070-9 ... receptor antagonists currently available for the treatment of seasonal allergic rhinitis. ...
Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants. [+] Quercetin inhibits IgE-mediated allergic conjunctivitis. ... Anti-Bacterial Agents, Anti-Inflammatory Agents, Anti-Ulcer Agents, Antimicrobial, Antiviral Agents, Contraceptive Agents, ... Pharmacological Actions : Anti-Inflammatory Agents, Antioxidants, Interleukin-4 downregulation, Tumor Necrosis Factor (TNF) ... Ginkgo biloba significantly improves symptoms of allergic conjunctivitis. May 01, 2009. Click here to read the entire abstract ...
Anti-allergic agent. DG01805 Mediator release inhibitor. DG00098 Cromoglicic acid. D00526 Cromolyn sodium. Drugs listed in the ... Ophthalmic Agents. Ophthalmic Anti-allergy Agents. Mast Cell Stabilizer. Cromolyn. D00526 Cromolyn sodium (USP). Respiratory ... 4 Agents affecting cellular function. 44 Allergic agents. 449 Miscellaneous. 4490 Miscellaneous. D00526 Cromolyn sodium (USP); ... A07E INTESTINAL ANTIINFLAMMATORY AGENTS. A07EB Antiallergic agents, excl. corticosteroids. A07EB01 Cromoglicic acid. D00526 ...
Categories: Anti-Allergic Agents Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Dermatologic Agents. Histamine H1 Antagonists. Histamine Antagonists. Histamine Agents. Neurotransmitter Agents. Anti-Allergic ... Sensory System Agents. Peripheral Nervous System Agents. Antitussive Agents. Respiratory System Agents. Antipruritics. ...
These agents provide no bronchodilatory effect but are useful in controlling the underlying inflammation of allergic asthma. ... Xanthine derivatives have been used in allergic asthma for their bronchodilatory and anti-inflammatory properties; however, ... Long-acting β-agonists have a greater selectivity for the β2 adrenoreceptors than the short-acting agents. These agents cause ... As with other agents in this class, beclomethasone dipropionate is also considered a third-line agent. ...
Female sex and the use of anti-allergic agents increase the risk of developing cutaneous rash associated with nevirapine ... In cases of drug toxicity, ,1 alternative drugs of the same potency and from the same class of agents as the suspected agent ... The availability of an increasing number of antiretroviral agents and the rapid evolution of new information has introduced ... this is an evolving science and the availability of new agents or new clinical data regarding the use of existing agents will ...
The prevalence of allergic skin disorders has increased rapidly, and development of therapeutic agents to alleviate the ... Availability of JAK Inhibitors on Allergic Dermatitis. Tomoki Fukuyama, Sarah Ehling, Elizabeth Cook and Wolfgang Bäumer ... Availability of JAK Inhibitors on Allergic Dermatitis. Tomoki Fukuyama, Sarah Ehling, Elizabeth Cook and Wolfgang Bäumer ... For the allergic dermatitis model, female BALB/c mice were sensitized and challenged with toluene-2,4-diisocyanate (TDI). Each ...
Syzygium cumini; anti-allergic agents; antioxidants; bioactive compounds; carotenoids; citronellol; cyanidin; fruits; ... due to its anti-inflammatory and anti-apoptotic properties. Here, we investigated whether the anti-inflammatory cytokine, IL-22 ... 5. Chlorogenic acid methyl ester exerts strong anti-inflammatory effects via inhibiting the COX-2/NLRP3/NF-κB pathway ... The objective of this study was to investigate the anti-inflammatory effect of chlorogenic acid methyl ester (CME) and the ...
133 Vertigo agents. 1339 Others. D01592 Betahistine mesilate (JP18). Drug groups [BR:br08330]. Anti-allergic agent. DG01557 ... Anti-allergic agent. DG01557 Histamine receptor antagonist. DG01556 Histamine receptor H3 antagonist. DG01004 Betahistine. ... Anti-allergic agent. DG01557 Histamine receptor antagonist. DG01556 Histamine receptor H3 antagonist. ... 1 Agents affecting nervous system and sensory organs. 13 Agents affecting sensory organs. ...
R01AC Antiallergic agents, excl. corticosteroids. Antihistamines, cromoglicate disodium and analogues are classified here. ... or for prophylaxis and treatment of allergic rhinitis (e.g. corticosteroids, cromoglicate preparations). Most of the products ...
Anti-Allergic Agents Medicine & Life Sciences 63% * Catechin Medicine & Life Sciences 61% ... Fujimura Y, Tachibana H, Maeda-Yamamoto M, Miyase T, Sano M, Yamada K. Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O ... To understand the mechanism of action for the antiallergic EGCG″3Me, the effect of EGCG″3Me on the cell surface expression of ... To understand the mechanism of action for the antiallergic EGCG″3Me, the effect of EGCG″3Me on the cell surface expression of ...
It also acts an anti-allergic agent in skin rash.. (Last Updated on : 24-03-2014) ...
Vitamin D acts as an agent that prevents and cures diseases such as rickets and osteomalac ... Cancer Tag: Anti-allergic. Misai Kucing Cancer Cure. Researchers from the University Sains Malaysia found that misai kucing has ... Kiwi Anti-Cancer. Recognizing an allergy early could save mothers and infants significantly aggravation and ...
Amlexanox is an anti-allergic and anti-inflammatory agent, prescribed for aphthous ulcers or canker sores in people with normal ... Acrivastine is an antiallergic drug used to treat hay fever causing sneezing and watery eyes, itchy red eye due to allergic ... is an antiallergic agent prescribed to treat or prevent itching due to eye irritation or pink eye associated with allergic ... Azatadine Maleate is an antihistaminic agent, which is used to provide relief from symptoms of allergic reactions such as rash ...
... the camphor tree Cinnamomum camphora and its components including dimethylmatairesinol have potential as an anti-allergic agent ... In vitro anti-inflammatory and anti-oxidative effects of Cinnamomum camphora extracts.. *H. Lee, Eun A. Hyun, +5 authors. E. ... Ethnomedicinal Plants from Iraq as Therapeutic Agents against Mycobacterium tuberculosis: A Review. *A. S. Dheyab, E. K. Shaker ... Current Insights on Bioactive Molecules, Antioxidant, Anti-Inflammatory, and Other Pharmacological Activities of Cinnamomum ...
People who are allergic to certain anesthetic agents may be anesthetized using alternatives and those allergic to certain blood ... Persons who are allergic to painkillers such as non-steroidal anti inflammatory drugs (NSAIDs) such as aspirin and ibuprofen ... Some persons might be severely allergic to contrast dyes and agents used for imaging studies. For example, contrast enhanced ... Those allergic to certain medications can safely use alternatives. For example, those who are allergic to penicillins and their ...
2). The anti-allergic agents tranilast (100 and 300 mg/kg; Fig. 2) and azelastine hydrochloride (30 mg/kg; Fig. 2) inhibit IL- ... Effect of anti-IL-31RA on IL-31-induced LTB4 production. Anti-31RA antibody (anti-31RA, 10 μg/ml) or non-specific ... IL-31-induced itch-related response was inhibited by anti-allergic drugs (tranilast and azelastine), but not by an H1 histamine ... However, anti-allergic drugs (tranilast and azelastine) attenuated IL-31-induced scratching. Tranilast has an inhibitory action ...
... describes an allergic reaction to an anti-wrinkle cream or severe skin inflammation after the use of a tattoo-removing agent. ... severe skin inflammation after using a tattoo-removing agent and other allergic reactions. The incorrect use of impregnating ... Impregnating sprays and tattoo-removing agents. 27/2008, 15.12.2008. BfR brochure documents intoxication cases from 2007 ... prove dangerous as illustrated by the case of a patient who drank several litres of water after swallowing a descaling agent. ...
anti-anxiety agents. Drug Class. anti-allergic agents. Year of Approval. approved before 1982. ...
Anesthetic Agents Anti-Allergic Agents Antibiotic and Antimicrobial Agents Pharmaceutical Intermediates Other see more less ...
... anti-HIV [6], antiparasitic [7], anti-inflammatory [8], and antidepressant [9] properties. After the recognition of vital ... For example, a short-acting agent (e.g., mepivacaine) will be useful for creation of excellent intraoperative conditions with ... during the metabolic process in the blood which cause allergic reactions that range from urticaria to anaphylaxis. In contrast ... The enhanced vasodilator activity of a local anesthetic agent results in shorter duration of action because of faster ...
Good alternative antibiotic for patients allergic or intolerant to the macrolide class. Usually is well tolerated and provides ... Nonsteroidal anti-inflammatory agents (NSAIDs). Class Summary. These drugs are used most commonly for relief of mild to ... Has analgesic, antipyretic, and anti-inflammatory effects. May inhibit cyclooxygenase enzyme, inhibiting prostaglandin ... good coverage to most infectious agents. Not effective against Mycoplasma and Legionella species. The half-life of oral dosage ...
Anti-Allergic Agents 25% * Cytokines 24% 26 引文 斯高帕斯(Scopus) ... Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells. Wu, W. C., Liu, Y. ... Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway ... Involvement of prostaglandin E2 in anti-promotive process. Ko, C. H., Shen, S. C., Lin, H. Y., Hou, W. C., Lee, W. R., Yang, L- ...
Overview of Allergic Diseases: Diagnosis, Management, and Barriers to Care. Vol 1-3. San Diego: AAAAI; 2000.. 10. Rachelefsky ... Guidelines for Using Anti-Inflammatory Agents in the Management of Asthma. Feb 7, 2007 , Asthma , ... Alternative agents for anti-inflammatory treatment of asthma. J Allergy Clin Immunol. 1998;102:S23-S35.. 7. Szefler SJ. Risks ... Corticosteroids are considered to be the most potent and effective anti-inflammatory agents currently available.8 ...
Anesthetic Agents (0)* *Animal Pharmaceuticals (0)* *Anti-Allergic Agents (0)* *Antibiotic and Antimicrobial Agents (0)* * ... Endocrine System Agents (0)* *Gastrointestinal Agents (0)* *Herbal Extract (0)* *Immune Function Agents (0)* *Pharmaceutical (0 ... Blood System Agents (0)* *Cardiovascular Agents (0)* *Central Nervous System Agents (0)* *Disinfectant and Preservatives (0)* * ... Respiratory System Agents (0)* *Urinary System Agents (0)* *Vitamins, Amino Acids and Coenzymes (0)* *Acrylic Adhesives (0)* * ...
We investigated the therapeutic potential for tranilast, an orally bioavailable anti-allergic agent, to prevent fibrosis in ... or a mouse chimera of anti-human myostatin antibody (PF-354, 10 mg·kg⁻¹·wk⁻¹, LLC+PF-354, n = 11) for 5 wk. Injection of LLC ...
RosA has a wide range of pharmacological effects, such as anti-oxidative, anti-apoptotic, anti-tumorigenic and anti- ... RosA has a wide range of pharmacological effects, including anti-oxidative, anti-apoptotic, anti-tumorigenic, and anti- ... The anti-inflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases ... The purpose of this review is to discuss the anti-inflammatory effects of RosA in inflammatory diseases and its underlying ...
  • A multicenter, double-blind, parallel-group, placebo-controlled trial compared the efficacy and safety of fexofenadine HCl (120 and 180 mg administered once daily) and cetirizine (10 mg once daily) in the treatment of seasonal allergic rhinitis. (nih.gov)
  • Once-daily fexofenadine is thus a valuable addition to the nonsedating group of H(1) receptor antagonists currently available for the treatment of seasonal allergic rhinitis. (nih.gov)
  • This group comprises preparations for local treatment in nasal congestion (e.g. sympathomimetics) or for prophylaxis and treatment of allergic rhinitis (e.g. corticosteroids, cromoglicate preparations). (whocc.no)
  • IL-31 plays a major role in the induction of chronic inflammation in diseases such as dermatitis, allergic rhinitis and asthma (6). (medicaljournals.se)
  • This is the reason that allergic rhinitis is the most common type of rhinitis. (cowurine.com)
  • The slow state of rhinitis ends automatically after a few weeks, but its severe and non-allergic condition can make a person nervous for a lifetime, greatly affecting their daily life. (cowurine.com)
  • Its active ingredient, curcumin, has been linked to reduced symptoms of many inflammation-driven diseases and could help minimize the swelling and irritation caused by allergic rhinitis. (cowurine.com)
  • Tulsi leaves are effective in fighting nasal congestion and other such symptoms of allergic rhinitis. (cowurine.com)
  • Sonth extract is an excellent anti-allergic and anti-inflammatory agent and it can relieve the symptoms of allergic rhinitis and improve the quality of life for people. (cowurine.com)
  • Versus Loratadine, the extract of sonth is powerfully used in the treatment of allergic rhinitis. (cowurine.com)
  • The anti-inflammatory properties of kali Mirch identified in specific diseases associated with inflammation such as allergic rhinitis. (cowurine.com)
  • The anti-allergic property of Kapoor helps for preventing and treating acute rhinitis, chronic rhinitis, allergic rhinitis. (cowurine.com)
  • One of the most common medicinal uses for black cumin is relieving allergic rhinitis , which is also called seasonal allergies because they are worse during the growing season. (naturalnews.com)
  • In some cases, allergies to pollen and mold, which are the most common causes of allergic rhinitis, can cause life-threatening symptoms. (naturalnews.com)
  • Because black cumin is often used as an herbal treatment for allergic rhinitis, researchers conducted studies to test its efficacy. (naturalnews.com)
  • In one study, researchers from Ahvaz Jundishapur University of Medical Sciences in Ahvaz, Iran investigated the anti-inflammatory effects of black cumin and its effects on inflammatory factors in people with allergic rhinitis. (naturalnews.com)
  • The researchers recruited 66 participants with allergic rhinitis and exposed them to either black cumin oil or placebo for 30 days. (naturalnews.com)
  • The researchers concluded that black cumin may be considered as a treatment for allergic rhinitis to avoid the adverse side effects of anti-allergic drugs. (naturalnews.com)
  • Another study also showed that black cumin oil is an effective treatment for allergic rhinitis . (naturalnews.com)
  • In this study, which was published in the journal Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry , researchers from Tikrit University in Iraq examined the effects of topical black cumin oil treatment on allergic rhinitis. (naturalnews.com)
  • For this study, the researchers recruited 68 participants with allergic rhinitis. (naturalnews.com)
  • Allergists are frequently faced with patients simultaneously suffering from 3 diseases - asthma, atopic dermatitis, and allergic rhinitis, a constellation recognized as the "atopic triad. (jci.org)
  • Asthma, allergic rhinitis, and atopic dermatitis are almost invariably accompanied by elevated levels of IgE. (jci.org)
  • The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease and depends on many factors. (bvsalud.org)
  • Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidelines have considerably improved the treatment of allergic rhinitis. (bvsalud.org)
  • In individuals predisposed to develop allergic disease(s), the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants). (mayocliniclabs.com)
  • The high-affinity IgE receptor, FcεRI, is found at high levels on basophils and mast cells and plays a key role in a series of acute and chronic human allergic reactions. (elsevier.com)
  • They include cases of workers who suffered disorders of the respiratory tract after opening fumigated transport containers, severe skin inflammation after using a tattoo-removing agent and other allergic reactions. (bund.de)
  • This course will highlight allergic reactions that dental patients may experience as a result of exposure to medications and materials used during and for dental treatment. (netce.com)
  • This course is designed for all dental professionals who may encounter allergic reactions in their practice. (netce.com)
  • The purpose of this course is to provide dental professionals with the information necessary to recognize, treat, and prevent allergic reactions in their patients. (netce.com)
  • Describe the pathophysiology of the various types of allergic reactions. (netce.com)
  • Review the antibiotics, analgesics, and local anesthetics used in dentistry that may cause allergic reactions. (netce.com)
  • Discuss the materials used in dentistry that may cause allergic reactions in susceptible individuals. (netce.com)
  • Evaluate the recommended treatment protocols and emergency medications used to treat allergic reactions. (netce.com)
  • Agents that are used to treat allergic reactions. (bvsalud.org)
  • They are hypoallergenic, which means they tend not to cause allergic reactions or worsen one's allergies. (towl.us)
  • Some people experience allergic reactions when they apply melaleuca oil to their skin. (hblack.net)
  • 1. Hypersensitivity or allergic reactions/conditions associated with ketorolac, pitofenone, fenpiverinium, any other components of IMPs, acetylsalicylic acid or other non-steroidal anti-inflammatory drugs. (who.int)
  • Prevention and treatment of allergic and psevdoalerhichnyh reactions, including reactions to the introduction of contrast agents, blood, diagnostic use of histamine. (pharmasstore.com)
  • Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. (cdc.gov)
  • This is not a very advisable procedure for all since some people may have allergic reactions to the chemicals. (bellytox.com)
  • It rarely causes allergic reactions. (clevelandclinic.org)
  • It's cheaper than others but many people have allergic reactions to it. (clevelandclinic.org)
  • Benefits of honey- Honey has also been shown to activate enzymes that break down adhesion molecules on mast cells in order to decrease their ability to cause allergic reactions (1). (rantrovehoney.in)
  • Aside from these ambient allergens, allergic reactions can result from foods , insect stings , and reactions to medications like aspirin and antibiotics such as penicillin . (mdwiki.org)
  • Natural products can cause allergic reactions in some people, test patch on inner elbow and leave for thirty minutes. (indulgeoessentials.com)
  • This process removes residual soaps and compounding agents that, if left in the process, can cause premature body sets, odor issues and potential allergic reactions. (brooklynbedding.com)
  • While antibiotics can usually treat UTIs quickly and effectively, they can cause allergic reactions and other adverse effects and complications. (medicalnewstoday.com)
  • help to treat eczema, reduces reactions in people allergic to nickel, and treats insect bites and staph infections. (bitesofwellness.blog)
  • Patients currently undergoing anti-neoplastic therapy including but not limited to the following: - Topical imiquimod - Topical 5-fluorouracil - Topical ingenol mebutate - Topical diclofenac - Topical retinoids - Oral acitretin - History of allergic reactions attributed to compounds of similar chemical or biologic composition to aminolevulinic acid - Patients with a known photosensitivity disorder including but not limited to porphyria, lupus, polymorphous light eruption, or immunobullous disease. (trialbulletin.com)
  • COVID-19 vaccines: Update on Allergic Reactions, Contraindications, and Precautions. (cdc.gov)
  • The confirmation to guidance to vaccination centers on managing allergic reactions following COVID-19 vaccination with the Pfizer-BioNTech vaccine. (cdc.gov)
  • Adlay bran extract can reduce an allergic reaction by balancing Th1/Th2 immune responses. (greenmedinfo.com)
  • If allergic the region shows redness and a reaction. (news-medical.net)
  • In these cases injections of antihistamines and corticosteroids given before the contrast agents may prevent an anaphylactoid reaction or at least reduce its severity. (news-medical.net)
  • It also describes an allergic reaction to an anti-wrinkle cream or severe skin inflammation after the use of a tattoo-removing agent. (bund.de)
  • However, always make sure to avoid using products with anti-acne agents like salicylic acid or benzoyl peroxide as it can cause a severe allergic reaction. (selfgrowth.com)
  • Because an allergic reaction can occur at any time during dental treatment, the ability to react and treat a patient that has experienced an allergic reaction is imperative. (netce.com)
  • Outline the importance of a patient's medical and dental history as a means of evaluating the potential for the development of an allergic reaction during dental treatment. (netce.com)
  • May produce an allergic reaction. (naturalcollection.com)
  • The doctor basically proved to the court that the childʼs allergic reaction to having peanut oil injected by vaccine had caused the massive brain swelling reaction that sent the boy into shock. (yogaesoteric.net)
  • Unpredictably, some allergic episodes have a late phase reaction which can occur four to twelve hours after exposure. (patient.info)
  • Erythema Multiforme is a skin condition arising from an allergic reaction. (targetwoman.com)
  • On the other hand, Erythema multiforme major (also known as Stevens Johnson syndrome ) is a severe allergic reaction resulting in large blood blisters. (targetwoman.com)
  • Despite the obvious health benefits, you should also take care not to apply too much of coconut oil on your skin as it might cause an allergic reaction or worsen your skin's condition. (beautyepic.com)
  • It's not only safety, when you inject somebody and they get maybe an idiosyncratic reaction, they get a little allergic reaction, they get pain. (blogspot.com)
  • Cows in confinement are routinely feed soy meal and other grains, which is not a natural diet for cows who were designed to eat grass, and people who have an allergic reaction to pasteurized milk often turn to soy milk. (nourishingourchildren.org)
  • Due to the increasing number of people who are having an allergic reaction to pasteurized milk products, soy dairy has emerged as an often sought out alternative. (nourishingourchildren.org)
  • Please remember to only use a small amount first, in case you have an allergic reaction. (bitesofwellness.blog)
  • These agents provide no bronchodilatory effect but are useful in controlling the underlying inflammation of allergic asthma. (medscape.com)
  • Acetaminophen and hydrocodone is a combination of non-opioid and narcotic or sleep-inducing agents used to treat moderate to severe pain associated with inflammation. (medindia.net)
  • It has great anti-inflammatory properties which help reduce the inflammation in the nose. (cowurine.com)
  • These include antihistamines for the treatment of allergic conditions, oral NSAIDs to alleviate pain and inflammation inside the eye, and oral corticosteroids. (petplace.com)
  • One study using lavender essential oil even noted that it may be able to suppress allergic airway inflammation. (wellme.com)
  • Honey is an anti-inflammatory and antioxidant, which means it helps to reduce the inflammation caused by allergies. (rantrovehoney.in)
  • Honey is a natural anti-inflammatory agent that can help with arthritis, allergies and skin inflammation. (rantrovehoney.in)
  • IgE functions in allergic responses: immediate hypersensitivity, allergen focusing, and IgE receptor regulation. (jci.org)
  • Allergies , also known as allergic diseases , are a number of conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment. (mdwiki.org)
  • Clinical manifestations of immediate hypersensitivity (allergic) diseases are caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE antibodies interact with allergen. (mayocliniclabs.com)
  • Persons who are allergic to painkillers such as non-steroidal anti inflammatory drugs (NSAIDs) such as aspirin and ibuprofen can safely take paracetamol for example. (news-medical.net)
  • Conventional treatments include analgesics, corticosteroids, and non-steroidal anti-inflammatory drugs (NSAIDs), which are most commonly used. (rateadrug.com)
  • The nonsteroidal anti-inflammatory drugs (NSAIDs) are agents similar in action to ibuprofen. (petplace.com)
  • tell your doctor and pharmacist if you are allergic to aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs) including ibuprofen (Advil, Motrin, others) and indomethacin (Indocin), omeprazole, any other medications, or any of the ingredients in the combination of aspirin and omeprazole delayed-release tablets. (medlineplus.gov)
  • Gastrointestinal (GI) intolerance of non-steroidal anti-inflammatory drugs (NSAIDs), lactose intolerance and simply not liking something are not allergies. (patient.info)
  • Among them, the nonsteroidal anti-inflammatory drugs (NSAIDs) are probably the most studied medications, showing effective outcomes in controllingperiodontal breakdown in pre-clinical experiments when systemically administered 3-5 . (bvsalud.org)
  • The anti-inflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. (frontiersin.org)
  • The purpose of this review is to discuss the anti-inflammatory effects of RosA in inflammatory diseases and its underlying mechanism. (frontiersin.org)
  • The CDC reports that 75% of Americans have detectable levels of triclosan in their urine, and epidemiological studies have found a positive correlation between triclosan burden and diagnosis of allergic diseases. (cdc.gov)
  • To our knowledge, this is the first report that triclosan can induce TSLP expression as a possible mechanism for augmenting allergic diseases. (cdc.gov)
  • IgE blockers have recently been developed and show some promise in the treatment of allergic diseases. (jci.org)
  • The cell-autonomous circadian clock regulates IgE- and IL-33-mediated mast cell activation, both of which are key events in the development of allergic diseases. (bvsalud.org)
  • Accordingly, clock modifiers could be used to treat allergic diseases, as well as many other circadian-related diseases, such as sleep and metabolic disorders. (bvsalud.org)
  • Interleukin-33 (IL-33)/ST2-mediated mast cell activation plays important roles in the pathophysiology of allergic diseases. (bvsalud.org)
  • Thus, resveratrol may have potential for the prevention and treatment of broad ranges of allergic diseases. (bvsalud.org)
  • [12] These diseases include hay fever , food allergies , atopic dermatitis , allergic asthma , and anaphylaxis . (mdwiki.org)
  • [20] Rates of many allergic diseases appear to be increasing. (mdwiki.org)
  • People who are allergic to certain anesthetic agents may be anesthetized using alternatives and those allergic to certain blood pressure lowering agents like angiotensin-converting enzyme (ACE) inhibitors maybe prescribed other agents. (news-medical.net)
  • However, in animal models of atopic dermatitis, the administration of anti-IL-31 antibody inhibited spontaneous scratching, but not dermatitis (12). (medicaljournals.se)
  • Here we will give a brief overview of the roles of IgE in allergic pathophysiology, and the molecular and cellular factors that ultimately regulate IgE production and Th2 expansion. (jci.org)
  • A genome-wide association study (n = 360,838) of a broad allergic disease phenotype identified 132 genes in allergic disease pathophysiology [ 4 ] . (patient.info)
  • Ginkgo biloba significantly improves symptoms of allergic conjunctivitis. (greenmedinfo.com)
  • 2. The patient has another disease/condition that requires constant use of non-topical analgesics and/or anti-inflammatory agents or, in the opinion of the investigator, disturbs the patient's perception of postoperative pain. (who.int)
  • The are two basic classes of topical anti-inflammatory medications that may be used to treat red eyes: nonsteroidal anti-inflammatory drugs and topical corticosteroids. (petplace.com)
  • Control agents include inhaled corticosteroids, long-acting bronchodilators (beta-agonists and anticholinergics), theophylline (Theo-24, Theochron, Uniphyl), leukotriene modifiers, anti-IgE antibodies, anti-interleukin (IL)-5 antibodies, and anti-IL-4/IL-13 antibodies. (medscape.com)
  • Allergies may take many forms, from mild specific food intolerance , hay fever and allergic conjunctivitis to life-threatening anaphylaxis . (patient.info)
  • As one of the best essential oils for allergies, eucalyptus may help alleviate some congestion via its anti-inflammatory properties. (wellme.com)
  • The pathophysiologic mechanisms that occur during the varied allergic responses, local and systemic manifestations, and emergency medications and treatment will be discussed. (netce.com)
  • Dermal exposure to the antimicrobial chemical triclosan augments allergic responses by inducing expression of thymic stromal lymphopoietin. (cdc.gov)
  • Mice exposed dermally to triclosan have also shown augmented allergic responses, however the mechanisms behind these effects are unknown. (cdc.gov)
  • In vivo administration of neutralizing anti-TSLP antibody impaired allergic responses augmented by dermal exposure to 3% triclosan during sensitization to ovalbumin. (cdc.gov)
  • Exposure to triclosan has previously been shown to be associated with allergic disease in humans and impact the immune responses in animal models. (cdc.gov)
  • Blueberry, combined with probiotics (BP), might be a potential candidate for NAFLD treatment, due to its anti-inflammatory and anti-apoptotic properties. (usda.gov)
  • Here, we investigated whether the anti-inflammatory cytokine, IL-22, was involved in the therapeutic process of BP, using cell and rat models of NAFLD. (usda.gov)
  • Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID), prescribed for fever and to relieve pain and swelling in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. (medindia.net)
  • Has analgesic, antipyretic, and anti-inflammatory effects. (medscape.com)
  • In recent years, the anti-inflammatory activity of natural products has attracted wide attention. (frontiersin.org)
  • RosA has a wide range of pharmacological effects, including anti-oxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. (frontiersin.org)
  • Mulethi is a very common natural material and has been found to have anti-inflammatory and immunomodulatory effects. (cowurine.com)
  • Haldi is well-known as an anti-inflammatory powerhouse for a good reason. (cowurine.com)
  • Kapoor exhibits anti-inflammatory effects. (cowurine.com)
  • It also has anti-inflammatory effects. (cowurine.com)
  • In higher concentrations, it works amazingly as an anti-inflammatory to reduce pustules, and red acne bumps. (selfgrowth.com)
  • Don't be scared of the term, Sulphur is a natural mineral that works like magic as an exfoliator and anti-inflammatory ingredient. (selfgrowth.com)
  • It is pure nature's bliss, known for its anti-inflammatory agent used to treat acne and excess oiliness. (selfgrowth.com)
  • Anti-inflammatory agents are used to counter this response. (rateadrug.com)
  • Anti-inflammatory medication. (petplace.com)
  • Systemic anti-inflammatory medications. (petplace.com)
  • Occasionally systemic anti-inflammatory medications are used in conjunction with topical medications. (petplace.com)
  • These tanshinones have been reported to exhibit antioxidative ( 6 - 9 ), anti-inflammatory ( 6 , 10 , 11 ), anti-allergic ( 12 ) and anti-cancer effects ( 13 , 14 ). (spandidos-publications.com)
  • The oil is widely marketed as an anti-inflammatory representative and is typically used to treat acne, athlete's foot, and lice. (hblack.net)
  • Introduction Bitter Kola (Garcinia Kola) and kola nut, contains substances attributed to numerous effects on humans including anti-inflammatory, anti-allergic properties, anti-infective and caffeinism. (bvsalud.org)
  • Abstract: In this study we evaluated the analgesic and anti- inflammatory activities of the methanol extract of stem bark of Diospyros cordifolia (MEDC) Roxb. (bvsalud.org)
  • MEDC also was evaluated for its anti-inflammatory potential against carrageenan, histamine and dextran induced rat paw edema. (bvsalud.org)
  • It also has nutritional benefits along with antioxidant and anti-inflammatory properties. (startus-insights.com)
  • Flavonoids are mainly used as anti oxidants but also function as anti inflammatory agents and help in preventing cancer. (sbwire.com)
  • Growing requirement for anti stress, anti-inflammatory, and low cholesterol supplements has led to the increase in demand for anti oxidants supplements which in turn are expected to drive the demand for flavonoids. (sbwire.com)
  • The senile population in North America consumes flavonoids on a large scale as flavanoids contain important antioxidants, and promote several health benefits owing to is anti-viral, anti-cancer, anti-inflammatory anti-allergic properties. (sbwire.com)
  • Studies have demonstrated that, in the form of alcoholic extracts, decoctions, and infusions, C. verbenacea exhibits important anti-rheumatic, anti-inflammatory, analgesic, and healing properties which are related to a protective effect on the gastric mucosa, as well as very low toxicity when orally or topically administered 12-17 . (bvsalud.org)
  • Taking into account the extensive presence of C. verbenacea in Brazilian folk medicine, and considering the anti-inflammatory activity previously reported 12-17 our group was prompted to assess the impact of C. verbenacea in modulating periodontal disease progression. (bvsalud.org)
  • For instance, some may open up your airways, while others possess anti-inflammatory effects. (wellme.com)
  • In short, lavender essential oil is anti-inflammatory. (wellme.com)
  • [8] While more research is needed on this specifically, it makes sense because lemon is such a powerful anti-inflammatory agent. (wellme.com)
  • Anti-inflammatory or immunosuppressive- 2.5-10 mg/kg/day or 75-300 mg/m 2 /day in 3-4 divided doses. (drugguide.com)
  • Bilirubin is recognised as acting as an antioxidant and anti-inflammatory agent in serum. (randox.com)
  • Its extract contains nearly 300 compounds that have antiviral [1], anti-bacterial, and anti-inflammatory properties. (apimemphis.com)
  • It also has powerful anti-ageing properties and will help the skin age gracefully as well as anti-inflammatory benefits to help with skin conditions such as acne and eczema. (indulgeoessentials.com)
  • Mandarin orange yogurt can be an effective nutritional intervention for allergic conjunctivitis. (greenmedinfo.com)
  • IL-31-induced itch-related response was inhibited by anti-allergic drugs (tranilast and azelastine), but not by an H 1 histamine receptor antagonist (terfenadine). (medicaljournals.se)
  • It works by blocking the release of certain natural substance histamine, which is responsible for allergic sympto ms. Histamine is produced when the body detects any foreign substances. (pharmeasy.in)
  • However, anti-histamine creams are better for individual bites. (pridemenj.com)
  • Although most of the commonly used drugs to treat EIA are in pregnancy category C, these agents are often used for asthma, which is a common condition of pregnancy. (medscape.com)
  • This agent can relieve bronchospasms by relaxing the smooth muscles of the bronchioles in conditions that are associated with bronchitis, emphysema, asthma, or bronchiectasis. (medscape.com)
  • Every bump comes with its own unique personality - redness, whiteheads, blackheads, puss-filled, each of them needs a different anti-acne messiah to treat them. (selfgrowth.com)
  • Alterations in the barrier and immune regulatory functions of the skin have been demonstrated to increase the risk of sensitization and development of allergic disease. (cdc.gov)
  • Albuterol is the drug of choice and first-line agent in the treatment of EIA. (medscape.com)
  • The availability of an increasing number of antiretroviral agents and the rapid evolution of new information has introduced substantial complexity into treatment regimens for persons infected with human immunodeficiency virus (HIV). (cdc.gov)
  • These anti-allergic effects were consistent until the end of the treatment, which could be attributed to the compounds in black cumin oil. (naturalnews.com)
  • Laser, also called light therapy is a form of anti aging treatment that uses light energy in repairing and regeneration of skin cells. (canadamedlaser.ca)
  • Vancomycin is a core antimicrobial vancomycin were reviewed and the reasons agent in the treatment of infections caused for prescribing this antibiotic were com- by Gram-positive pathogens. (who.int)
  • The pivotal study evaluated the combination of KEYTRUDA, Merck's anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, versus chemotherapy (treatment of physician's choice of doxorubicin or paclitaxel) for patients with advanced endometrial carcinoma following at least one prior platinum-based regimen in any setting. (merck.com)
  • It is used as an anti-aging treatment as well. (bevu.in)
  • In the United States topical aminolevulinic acid (ALA) is approved as a photosensitizing agent for this treatment, and it has traditionally been activated with the use of an in-office artificial light source. (trialbulletin.com)
  • Cromolyn sodium is a first- or second-line agent in the prevention of EIA but should not be used as rescue therapy for acute bronchospasm. (medscape.com)
  • Serologic testing to detect IgM antibody to the capsid proteins of HAV (IgM anti-HAV) is required to confirm a diagnosis of acute HAV infection. (cdc.gov)
  • Click to view Terramycin Plus detailed prescribing information Antihistamine creams, which can also be called anti-itch creams, are used to relieve pain and itching due to insect bites, minor cuts and burns, and resolve rashes due to an allergy or plants such. (pridemenj.com)
  • analgesic and often times anti pyretic roperties. (bvsalud.org)
  • Following are some of the current research studies in support of the use of Astragalus to treat a wide variety of allergic and autoimmune conditions, as well as some sample formulas in which to use this safe, versatile, and decent-tasting herb. (ndnr.com)
  • For example, those who are allergic to penicillins and their derivative drugs can safely be given other antibiotics. (news-medical.net)
  • When normal food becomes extremely toxic to children, the parents should review how those specific ingredients have been introduced to their infantʼs bodies, and what other dangerous "trace amounts" of carcinogens, antibiotics, adjuvants, emulsifiers, preservatives, additives, brewing agents, carriers and "immune response stimulants" are being injected into the body repeatedly for no logical reason. (yogaesoteric.net)
  • An antibacterial and bacteriostatic bio-agent known as 'Bamboo Kun' is primarily responsible for bamboo towels' antibacterial properties. (towl.us)
  • It is also used to make photographs, in brazing alloys and solders, to disinfect drinking water and water in swimming pools, and as an antibacterial agent. (cdc.gov)
  • It is naturally mold, mildew and dust mite resistant and is inherently antibacterial and anti-fungal. (brooklynbedding.com)
  • It is necessary to wash realistic masturbators from the spray because an antibacterial agent can irritate the delicate skin of the penis. (pamperedpassions.com)
  • Furthermore, the combination of S. miltiorrhiza and its active constituents with other TCM or chemotherapeutic substances has been observed to result in more notable anti-cancer effects compared with either agent alone ( 16 , 17 ). (spandidos-publications.com)
  • Thus KCs could be identified for immunoactive substances and applied to improve hazard assessment of immunodulatory agents. (cdc.gov)
  • The present invention relates to methods for treating pruritus with anti-pruritic compositions. (justia.com)
  • The prevalence of allergic skin disorders has increased rapidly, and development of therapeutic agents to alleviate the symptoms are still needed. (aspetjournals.org)
  • Acenocoumarol is a blood thinner agent prescribed to treat or prevent the formation of blood clots or thrombus in the blood vessels helps by dissolving the blood clots and reducing the complication of thromboembolic disorders. (medindia.net)
  • Piperine present in kali mirch has been used as an anti-allergy which has beneficial effects on nasal disorders. (cowurine.com)
  • it has also demonstrated anti-tumor, anti-viral, anti-allergy, and anti-diabetic activities. (ndnr.com)
  • Allergy to occupational or environmental agents (eg, house dust mite) is also extremely common and increasing [ 7 ] . (patient.info)
  • For the allergic dermatitis model, female BALB/c mice were sensitized and challenged with toluene-2,4-diisocyanate (TDI). (aspetjournals.org)
  • The oral administration of this medicinal herb appears to exhibit negligible effects on the pharmacokinetics of therapeutic agents, such as docetaxel or clopidogrel, indicating the potential benefits of combining S. miltiorrhiza with standard therapeutics ( 15 ). (spandidos-publications.com)
  • Those allergic to certain medications can safely use alternatives. (news-medical.net)
  • Aspirin is in a class of medications called antiplatelet agents. (medlineplus.gov)
  • Failure of therapy at 4--6 months might be ascribed to nonadherence, inadequate potency of drugs or suboptimal levels of antiretroviral agents, viral resistance, and other factors that are poorly understood. (cdc.gov)
  • Non-allergic food intolerances (eg, toxins and drugs, such as that due to monosodium glutamate causing Chinese restaurant syndrome). (patient.info)
  • Anticholinergic agents may potentially alter the absorption of some concomitantly administered drugs due to effects of gastrointestinal motility. (nih.gov)
  • HAV, a 27-nm RNA agent classified as a picornavirus, can produce either asymptomatic infection or symptomatic infection in humans after an average incubation period of 28 days (range: 15-50 days) (5). (cdc.gov)
  • It also acts an anti-allergic agent in skin rash. (indianetzone.com)
  • They also underwent a skin test to prove that their symptoms were allergic in nature. (naturalnews.com)
  • Thus, in clinical practice, allergen-specific IgE (as demonstrated by skin testing or in vitro assays) is generally believed to be inextricably connected to the induction of allergic airway symptoms, and is used as a guide for environmental modification and immunotherapy. (jci.org)
  • Listed below are a few nonsurgical anti-aging skin treatments that can help you look refreshed, young and beautiful! (canadamedlaser.ca)
  • This is an anti-ageing and anti-wrinkling agent that helps the skin to regenerate. (bellytox.com)
  • Triclosan is an anti-microbial chemical incorporated into products that are applied to the skin of healthcare workers. (cdc.gov)
  • But there are other fatty acids such as oleic acid and stearic acid which have all been used as ingredients in anti-acne products and skin moisturizers. (beautyepic.com)
  • Olive oil extracts have always been used to moisturize and smoothen the skin, so it works well with Vitamin E to fight off the agents that make our skin look older. (beautyepic.com)
  • Zinc deficiency may also have an impact on the carcinogenesis of other chemicals, although the direction of the influence seems to vary with the carcinogenic agent. (cdc.gov)
  • The clinical association of these conditions, as well as their cosegregation in affected family members within allergic pedigrees, has long suggested common underlying pathophysiologic mechanisms. (jci.org)
  • Its anti-bacterial properties will prevent whiteheads as well as blackheads. (selfgrowth.com)
  • It has anti-allergic, cough suppressant and decongestant properties. (pharmeasy.in)
  • BACKGROUND: Key characteristics (KCs), properties of agents or exposures that confer potential hazard, have been developed for carcinogens and other toxicant classes. (cdc.gov)
  • It is also enriched with great anti-ageing properties. (indulgeoessentials.com)
  • In vitro serum testing for IgE antibodies provides an indication of the immune response to allergen(s) that may be associated with allergic disease. (mayocliniclabs.com)
  • Olkem Beta 50 Tablet 10's belongs to the class antihypertensive agents used to treat hypertension (high blood pressure). (apollopharmacy.in)
  • However, drinking large amounts of water can also prove dangerous as illustrated by the case of a patient who drank several litres of water after swallowing a descaling agent. (bund.de)
  • 60 young patients were selected (between 18-28 years), who used randomly (by lottery) the whitening gel DA (with desensitizing agent) or whitening gel CO (without desensitizing agent) characterized as control of a double-blind study, ie the patient and the evaluator did not know the product that was being used. (bvsalud.org)