Cyclofenil: A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.Benz(a)Anthracenes: Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Benzopyrenes: A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.Chrysenes: 1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.PhenanthrenesCarcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Skin Neoplasms: Tumors or cancer of the SKIN.9,10-Dimethyl-1,2-benzanthracene: 7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Gasoline: Volative flammable fuel (liquid hydrocarbons) derived from crude petroleum by processes such as distillation reforming, polymerization, etc.Pyrenes: A group of condensed ring hydrocarbons.HydrocarbonsBenzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Vehicle Emissions: Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)Environmental Monitoring: The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.Hydrocarbons, Aromatic: Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.Geologic Sediments: A mass of organic or inorganic solid fragmented material, or the solid fragment itself, that comes from the weathering of rock and is carried by, suspended in, or dropped by air, water, or ice. It refers also to a mass that is accumulated by any other natural agent and that forms in layers on the earth's surface, such as sand, gravel, silt, mud, fill, or loess. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1689)Solid Phase Microextraction: A solventless sample preparation method, invented in 1989, that uses a fused silica fiber which is coated with a stationary phase. It is used for sample cleanup before using other analytical methods.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Mouth Protectors: Devices or pieces of equipment placed in or around the mouth or attached to instruments to protect the external or internal tissues of the mouth and the teeth.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Water Pollutants, Chemical: Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.Grape Seed Extract: Exudate from seeds of the grape plant Vitis vinifera, composed of oils and secondary plant metabolites (BIOFLAVONOIDS and polyphenols) credited with important medicinal properties.Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.Vitis: A plant genus in the family VITACEAE, order Rhamnales, subclass Rosidae. It is a woody vine cultivated worldwide. It is best known for grapes, the edible fruit and used to make WINE and raisins.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Phosgene: A highly toxic gas that has been used as a chemical warfare agent. It is an insidious poison as it is not irritating immediately, even when fatal concentrations are inhaled. (From The Merck Index, 11th ed, p7304)Wheat Germ Agglutinins: Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.Triticum: A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.Wine: Fermented juice of fresh grapes or of other fruit or plant products used as a beverage.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Biflavonoids: Dimers (homo and hetero) of FLAVONOIDS.Triazines: Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.Misonidazole: A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.Pharmacological Processes: The metabolism of drugs and their mechanisms of action.Aziridines: Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.Databases, Chemical: Databases devoted to knowledge about specific chemicals.NitroimidazolesNitracrine: Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.Indolequinones: INDOLES which have two keto groups forming QUINONES like structures of the indole aromatic ring.Nanotubes, Carbon: Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Absorption: The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.Adamantane: A tricyclo bridged hydrocarbon.Mycobacteriaceae: A family of gram-positive bacteria found in soil and dairy products and as parasites on animals and man. Several are important pathogens.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Hydrocarbons, Cyclic: Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Cinchona Alkaloids: Alkaloids extracted from various species of Cinchona.Electrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Electrodes, Implanted: Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.Ion-Selective Electrodes: Electrodes which can be used to measure the concentration of particular ions in cells, tissues, or solutions.Phytoplankton: Free-floating minute organisms that are photosynthetic. The term is non-taxonomic and refers to a lifestyle (energy utilization and motility), rather than a particular type of organism. Most, but not all, are unicellular algae. Important groups include DIATOMS; DINOFLAGELLATES; CYANOBACTERIA; CHLOROPHYTA; HAPTOPHYTA; CRYPTOMONADS; and silicoflagellates.Electrochemistry: The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.Oceans and Seas: A great expanse of continuous bodies of salt water which together cover more than 70 percent of the earth's surface. Seas may be partially or entirely enclosed by land, and are smaller than the five oceans (Atlantic, Pacific, Indian, Arctic, and Antarctic).Seawater: The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.Electrochemical Techniques: The utilization of an electrical current to measure, analyze, or alter chemicals or chemical reactions in solution, cells, or tissues.Foramen Ovale, Patent: A condition in which the FORAMEN OVALE in the ATRIAL SEPTUM fails to close shortly after birth. This results in abnormal communications between the two upper chambers of the heart. An isolated patent ovale foramen without other structural heart defects is usually of no hemodynamic significance.EthersPoloxalene: A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.KetonesPolymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Transition Temperature: The temperature at which a substance changes from one state or conformation of matter to another.Glass: Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.Poloxamer: A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.Micelles: Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.Calorimetry, Differential Scanning: Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.Manuscripts as Topic: Compositions written by hand, as one written before the invention or adoption of printing. A manuscript may also refer to a handwritten copy of an ancient author. A manuscript may be handwritten or typewritten as distinguished from a printed copy, especially the copy of a writer's work from which printed copies are made. (Webster, 3d ed)Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Manuscripts, MedicalPeer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Bibliometrics: The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)Journalism, Medical: The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Nursing Homes: Facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)Crystallization: The formation of crystalline substances from solutions or melts. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Microscopy, Polarization: Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.Carbon: A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.Data Display: The visual display of data in a man-machine system. An example is when data is called from the computer and transmitted to a CATHODE RAY TUBE DISPLAY or LIQUID CRYSTAL display.Halogenation: Covalent attachment of HALOGENS to other compounds.Anthracenes: A group of compounds with three aromatic rings joined in linear arrangement.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Chromatids: Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Anthraquinones: Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.Kinetics: The rate dynamics in chemical or physical systems.Alkadienes: Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Blood Transfusion: The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)Body Temperature: The measure of the level of heat of a human or animal.Body Temperature Regulation: The processes of heating and cooling that an organism uses to control its temperature.Equipment Design: Methods of creating machines and devices.Heating: The application of heat to raise the temperature of the environment, ambient or local, or the systems for accomplishing this effect. It is distinguished from HEAT, the physical property and principle of physics.Erythrocyte Transfusion: The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Biomedical Research: Research that involves the application of the natural sciences, especially biology and physiology, to medicine.Research Support as Topic: Financial support of research activities.Research Personnel: Those individuals engaged in research.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.Ethics, Research: The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.Nursing Research: Research carried out by nurses, generally in clinical settings, in the areas of clinical practice, evaluation, nursing education, nursing administration, and methodology.Health Services Research: The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)Translational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.

Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (1/915)

Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators.  (+info)

Formation of bound residues during microbial degradation of [14C]anthracene in soil. (2/915)

Carbon partitioning and residue formation during microbial degradation of polycyclic aromatic hydrocarbons (PAH) in soil and soil-compost mixtures were examined by using [14C]anthracenes labeled at different positions. In native soil 43.8% of [9-14C]anthracene was mineralized by the autochthonous microflora and 45.4% was transformed into bound residues within 176 days. Addition of compost increased the metabolism (67.2% of the anthracene was mineralized) and decreased the residue formation (20. 7% of the anthracene was transformed). Thus, the higher organic carbon content after compost was added did not increase the level of residue formation. [14C]anthracene labeled at position 1,2,3,4,4a,5a was metabolized more rapidly and resulted in formation of higher levels of residues (28.5%) by the soil-compost mixture than [14C]anthracene radiolabeled at position C-9 (20.7%). Two phases of residue formation were observed in the experiments. In the first phase the original compound was sequestered in the soil, as indicated by its limited extractability. In the second phase metabolites were incorporated into humic substances after microbial degradation of the PAH (biogenic residue formation). PAH metabolites undergo oxidative coupling to phenolic compounds to form nonhydrolyzable humic substance-like macromolecules. We found indications that monomeric educts are coupled by C-C- or either bonds. Hydrolyzable ester bonds or sorption of the parent compounds plays a minor role in residue formation. Moreover, experiments performed with 14CO2 revealed that residues may arise from CO2 in the soil in amounts typical for anthracene biodegradation. The extent of residue formation depends on the metabolic capacity of the soil microflora and the characteristics of the soil. The position of the 14C label is another important factor which controls mineralization and residue formation from metabolized compounds.  (+info)

Diverse oxygenations catalyzed by carbazole 1,9a-dioxygenase from Pseudomonas sp. Strain CA10. (3/915)

Carbazole 1,9a-dioxygenase (CARDO) from Pseudomonas sp. strain CA10 is a multicomponent enzyme that catalyzes the angular dioxygenation of carbazole, dibenzofuran, and dibenzo-p-dioxin. It was revealed by gas chromatography-mass spectrometry and 1H and 13C nuclear magnetic resonance analyses that xanthene and phenoxathiin were converted to 2,2',3-trihydroxydiphenylmethane and 2,2',3-trihydroxydiphenyl sulfide, respectively. Thus, for xanthene and phenoxathiin, angular dioxygenation by CARDO occurred at the angular position adjacent to the oxygen atom to yield hetero ring-cleaved compounds. In addition to the angular dioxygenation, CARDO catalyzed the cis dihydroxylation of polycyclic aromatic hydrocarbons and biphenyl. Naphthalene and biphenyl were converted by CARDO to cis-1, 2-dihydroxy-1,2-dihydronaphthalene and cis-2,3-dihydroxy-2, 3-dihydrobiphenyl, respectively. On the other hand, CARDO also catalyzed the monooxygenation of sulfur heteroatoms in dibenzothiophene and of the benzylic methylenic group in fluorene to yield dibenzothiophene-5-oxide and 9-hydroxyfluorene, respectively. These results indicate that CARDO has a broad substrate range and can catalyze diverse oxygenation: angular dioxygenation, cis dihydroxylation, and monooxygenation. The diverse oxygenation catalyzed by CARDO for several aromatic compounds might reflect the differences in the binding of the substrates to the reaction center of CARDO.  (+info)

Comparative tumorigenicity of the cyclopenta-fused polycyclic aromatic hydrocarbons aceanthrylene, dihydroaceanthrylene and acephenanthrylene in preweanling CD-1 and BLU:Ha mouse bioassays. (4/915)

Cyclopenta-fused polycyclic aromatic hydrocarbons are ubiquitous environmental pollutants and potential human health biohazards. In this study, the tumorigenicity of three single cyclopenta-fused polycyclic aromatic hydrocarbons, aceanthrylene, dihydroaceanthrylene and acephenanthrylene, was examined in preweanling CD-1 and BLU:Ha mouse bioassays at total doses of 175, 437.5 and 875 micrograms/mouse. No death or significant toxicity was observed with the treatment protocol in the tested animals. In CD-1 mice, a significant increase in lung tumor incidence (18-26%, P < 0. 025-0.01) for these three compounds was recorded in animals treated with 875 micrograms as compared with the control animals (3%). Significant numbers of liver tumors (25-41%, P < 0.01-0.001) were induced in all aceanthrylene treatment groups and in animals treated with 875 micrograms acephenanthrylene (35%) at the termination at 9 months. Most liver tumors were induced in male animals. The ED50 values were estimated as 8.5, 10.6 and 12.8 micromol and the TM1.0 were 15.1, 20.4 and 23.1 micromol for aceanthrylene, acephenanthrylene and dihydroaceanthrylene, respectively. In BLU:Ha mice, there was a significant dose-dependent increase in lung tumor incidence, from 4% for the control group to 33% (P < 0.001) for the animals treated with 875 micrograms aceanthrylene and to 24% (P < 0.02) for the animals treated with 437.5 micrograms acephenanthrylene. The ED50 values were 6.0 and 4.4 micromol and the TM1.0 were 9.8 and 6.8 micromol for aceanthrylene and acephenanthrylene, respectively. No significant difference in lung tumor incidence between male and female mice was found. Based on these data and comparisons of tumorigenic potency with other polycyclic aromatic hydrocarbons previously tested in these newborn mouse bioassays, aceanthrylene and acephenanthrylene were classified as weak tumorigens.  (+info)

Myeloma cells selected for resistance to CD95-mediated apoptosis are not cross-resistant to cytotoxic drugs: evidence for independent mechanisms of caspase activation. (5/915)

We have previously shown that selection for resistance to the anthracenes, doxorubicin or mitoxantrone, results in coselection for resistance to CD95-mediated apoptosis (Landowski et al: Blood 89:1854, 1997). In the present study, we were interested in determining if the converse is also true; that is, does selection for CD95 resistance coselect for resistance to chemotherapeutic drugs. To address this question, we used two isogenic models of CD95-resistant versus CD95-sensitive cell lines: 8226/S myeloma cells selected for resistance to CD95-mediated apoptosis; and K562 cells expressing ectopic CD95. Repeated exposure of the CD95-sensitive human myeloma cell line, 8226/S, to agonistic anti-CD95 antibody resulted in a cell line devoid of CD95 receptor surface expression and completely resistant to CD95-mediated apoptosis. Multiple clonal populations derived from the CD95-resistant cell line showed no difference in sensitivity to doxorubicin, mitoxantrone, Ara-C, or etoposide, demonstrating that cross-resistance between Fas-mediated apoptosis and drug-induced apoptosis occurs only when cytotoxic drugs are used as the selecting agent. Using the inverse approach, we transfected the CD95-negative cell line, K562, with a CD95 expression vector. Clones expressing variable levels of cell-surface CD95 were isolated by limiting dilution, and analyzed for sensitivity to CD95-mediated apoptosis and response to chemotherapeutic drugs. We show that CD95 surface expression confers sensitivity to CD95-mediated apoptosis; however, it does not alter response to chemotherapeutic drugs. Similarly, doxorubicin-induced activation of caspases 3 and 8 was identical in the CD95-sensitive and CD95-resistant cell lines in both isogenic cell systems. In addition, prior treatment with the CD95 receptor-blocking antibody, ZB4, inhibited CD95-activated apoptosis in 8226/S cells, but had no effect on doxorubicin cytotoxicity. These results show that CD95 and chemotherapeutic drugs use common apoptotic effectors, but the point of convergence in these two pathways is downstream of CD95 receptor/ligand interaction.  (+info)

Development of a new bioluminescent mutagenicity assay based on the Ames test. (6/915)

A newly developed rapid mutagenicity assay based on the adenosine triphosphate (ATP)-bioluminescence technique and the Ames test is described. Salmonella typhimurium strains TA98 and TA100 were exposed in an appropriate liquid medium to the direct mutagens 4-nitroquinoline-N-oxide and methyl methanesulphonate, respectively, and to the indirect mutagen 2-aminoanthracene. Both auxotrophic and prototrophic growth were monitored throughout the incubation period as variations in the intracellular ATP levels by means of the luciferin-luciferase assay. After 9-12 h of incubation a dose-response increase in the levels of ATP was readily detected. In order to demonstrate that this increase was due to the growth of revertant bacteria, aliquots from each culture were plated on minimal agar plates. A very good correlation between the changes in ATP levels and the appearance of revertant colonies on the plates was found. Given the rapidity of this method as compared with conventional mutagenicity assays, it has potential for industrial and environmental applications. Other potential applications are also discussed.  (+info)

Polycyclic aromatic hydrocarbon metabolism by white rot fungi and oxidation by Coriolopsis gallica UAMH 8260 laccase. (7/915)

We studied the metabolism of polycyclic aromatic hydrocarbons (PAHs) by using white rot fungi previously identified as organisms that metabolize polychlorinated biphenyls. Bran flakes medium, which has been shown to support production of high levels of laccase and manganese peroxidase, was used as the growth medium. Ten fungi grown for 5 days in this medium in the presence of anthracene, pyrene, or phenanthrene, each at a concentration of 5 microg/ml could metabolize these PAHs. We studied the oxidation of 10 PAHs by using laccase purified from Coriolopsis gallica. The reaction mixtures contained 20 microM PAH, 15% acetonitrile in 60 mM phosphate buffer (pH 6), 1 mM 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS), and 5 U of laccase. Laccase exhibited 91% of its maximum activity in the absence of acetonitrile. The following seven PAHs were oxidized by laccase: benzo[a]pyrene, 9-methylanthracene, 2-methylanthracene, anthracene, biphenylene, acenaphthene, and phenanthrene. There was no clear relationship between the ionization potential of the substrate and the first-order rate constant (k) for substrate loss in vitro in the presence of ABTS. The effects of mediating substrates were examined further by using anthracene as the substrate. Hydroxybenzotriazole (HBT) (1 mM) supported approximately one-half the anthracene oxidation rate (k = 2.4 h(-1)) that ABTS (1 mM) supported (k = 5.2 h(-1)), but 1 mM HBT plus 1 mM ABTS increased the oxidation rate ninefold compared with the oxidation rate in the presence of ABTS, to 45 h(-1). Laccase purified from Pleurotus ostreatus had an activity similar to that of C. gallica laccase with HBT alone, with ABTS alone, and with 1 mM HBT plus 1 mM ABTS. Mass spectra of products obtained from oxidation of anthracene and acenaphthene revealed that the dione derivatives of these compounds were present.  (+info)

Nepalolide A inhibits the expression of inducible nitric oxide synthase by modulating the degradation of IkappaB-alpha and IkappaB-beta in C6 glioma cells and rat primary astrocytes. (8/915)

1 The effects of nepalolide A on the expression of inducible nitric oxide synthase (iNOS) caused by incubation with lipopolysaccharide/interferon-gamma (LPS/IFN-gamma) or tumour necrosis factor-alpha/interleukin-1beta/IFN-gamma (TNF-alpha/IL-1beta/IFN-gamma, mixed cytokines) in C6 glioma cells and primary astrocytes of rat were investigated. The mechanisms by which nepalolide A confers its effect on iNOS expression were also elucidated. 2 Treatment with LPS/IFN-gamma and mixed cytokines for 24 h elicited the induction of iNOS activity as determined by nitrite accumulation in the culture medium and assay of enzyme activity. Nepalolide A at 10 microM abrogated the LPS/IFN-gamma- and mixed cytokines-mediated induction of iNOS by more than 90% in C6 glioma cells, and by 80% for mixed cytokines-induced induction of iNOS in primary astrocytes. The effect of nepalolide A (2-10 microM) was concentration-dependent. 3 The inhibition of iNOS induction by nepalolide A was attributed to decreases in the content of iNOS protein and the level of iNOS mRNA, as measured by immunoblotting and reverse transcriptase-polymerase chain reaction. 4 Electrophoretic mobility shift assay was used to evaluate the effect of nepalolide A on the activation of nuclear factor-kappaB (NF-kappaB). Results showed that nepalolide A diminished the LPS/IFN-gamma-mediated association of NF-kappaB with consensus oligonucleotide in a concentration-dependent manner. The activation of NF-kappaB by mixed cytokines was modulated both in the extent of activation and in its time-course by nepalolide A. 5 The ability of nepalolide A to inhibit NF-kappaB activation was further confirmed by studies on the degradation of the inhibitor of NF-kappaB, IkappaB, as measured by immunoblotting. 6 The present study demonstrates that the attenuation of NF-kappaB activation by nepalolide A was mediated by blockade of the degradation of IkappaB, leading to suppression of the expression of iNOS.  (+info)

*Aromaticity

... anthracene, and phenanthrene. In fused aromatics, not all carbon-carbon bonds are necessarily equivalent, as the electrons are ...

*Anthracene

... is used in the production of the red dye alizarin and other dyes. Anthracene is colorless but exhibits a blue (400- ... The anthracene tracer allows the conformal coating to be inspected under UV light. Anthracene is one of the three components ( ... Reduction of anthracene with alkali metals yields the deeply colored radical anion salts M+[anthracene]− (M = Li, Na, K). ... Anthracene also reacts with dienophile singlet oxygen in a [4+2]-cycloaddition (Diels-Alder reaction): Anthracene is converted ...

*Benz(a)anthracene

Benz[a]anthracene or benzo[a]anthracene is a polycyclic aromatic hydrocarbon with the chemical formula C18H12. In February 2014 ... Benz(a)anthracene is a constituent of tobacco smoke. Tetracene, also known as benz[b]anthracene Nomenclature of Organic ... anthracene, in the universe. According to scientists, more than 20% of the carbon in the universe may be associated with PAHs, ...

*Dibenz(a,h)anthracene

Dibenz[a,h]anthracene is an organic compound with the chemical formula C22H14. It is a polycyclic aromatic hydrocarbon made of ...

*Dibenz(a,j)anthracene

Dibenz[a,j]anthracene is an organic compound with the chemical formula C22H14. In February 2014, NASA announced a greatly ... upgraded database for tracking polycyclic aromatic hydrocarbons (PAHs), including dibenz[a,j]anthracene, in the universe. ...

*7,12-Dimethylbenz(a)anthracene

... at Sigma-Aldrich Miyata M; Furukawa M; Takahashi K; Gonzalez FJ; Yamazoe Y (2001). "Mechanism of ... 7,12-Dimethylbenz[a]anthracene (DMBA) is an immunosuppressor and a powerful organ-specific laboratory carcinogen. DMBA is ... 7, 12-Dimethylbenz[a]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ". Jpn J Pharmacol. 86 ...

*9,10-Bis(phenylethynyl)anthracene

The emission wavelength can be lowered by substituting the anthracene core by halogens or alkyls. 2-ethyl and 1,2-dimethyl ... 1-chloro-9,10-bis(phenylethynyl)anthracene emits yellow-green light, used in 30-minute high-intensity Cyalume sticks 2-chloro-9 ... 9,10-Bis(phenylethynyl)anthracene (BPEA) is an aromatic hydrocarbon with the chemical formula is C30H18. It displays strong ... 10-bis(phenylethynyl)anthracene emits green light, used in 12-hour low-intensity Cyalume sticks Lightstick Organic light- ...

*2-Chloro-9,10-bis(phenylethynyl)anthracene

... is a fluorescent dye used in lightsticks. It emits green light, used in 12-hour low- ... 9,10-Bis(phenylethynyl)anthracene 1-Chloro-9,10-bis(phenylethynyl)anthracene. ...

*1-Chloro-9,10-bis(phenylethynyl)anthracene

... is a fluorescent dye used in lightsticks. It emits yellow-green light, used in 30- ... 9,10-Bis(phenylethynyl)anthracene 2-Chloro-9,10-bis(phenylethynyl)anthracene. ...

*Retro-Diels-Alder reaction

I. Via anthracene adducts". Polym. Sci., Polym. Chem. Ed. 16 (10): 2475. Bibcode:1978JPoSA..16.2475B. doi:10.1002/pol. ... anthracene > butadiene Dienophile: N2 > CO2 > naphthalene > benzene, nitriles > methacrylate > maleimides > cyclopentadiene, ...

*Organic mineral

Other PAC compounds appearing as minerals include fluorene as kratochvilite; and anthracene as ravatite. Others are mixtures: ...

*4+4 Photocycloaddition

The earliest example of a [4+4] photocycloaddition was the photodimerization of anthracene, discovered in 1936. This reaction ... 2+2] Photocycloaddition Cycloaddition Fieser, Louis F.; Lothrop, Warren C. (1936). "The Structure of Anthracene". J. Am. Chem. ... Other polycyclic aromatics undergo anthracene-like photocycloaddition, such as acridizinium salts. Biologically active natural ...

*5,12-Bis(phenylethynyl)naphthacene

9,10-bis(phenylethynyl)anthracene. ...

*Vilsmeier-Haack reaction

Similarly, anthracene can be formylated exclusively at the 9-position. The reaction of anthracene with N-methylformanilide, ... "Formylation of anthracene". Organic Syntheses. 20: 11. doi:10.15227/orgsyn.020.0011. ; Collective Volume, 3, p. 98 Jones, G.; ...

*Sandwich compound

Begley, Michael J.; Puntambekar, Shakher G.; Anthony H., Wright (1987). "A di-iron-anthracene complex via ultrasonics". J. Chem ...

*Cyanonickelate

Anthracene, Phenanthrene or Biphenyl)". Journal of Inclusion Phenomena and Macrocyclic Chemistry. 39 (1/2): 175-180. doi: ...

*2-Chloro-9,10-diphenylanthracene

2-Chloro-9,10-bis(phenylethynyl)anthracene. ...

*4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase

This enzyme participates in naphthalene and anthracene degradation. Barnsley EA (1983). "Phthalate pathway of phenanthrene ...

*Time of flight

Time-of-flight camera Travel time Time of arrival R.G. Kepler (1960). "Charge Carrier Production and Mobility in Anthracene ...

*hydroxyamino)benzene mutase

This enzyme participates in naphthalene and anthracene degradation. He Z, Nadeau LJ, Spain JC (2000). "Characterization of ...

*Carbolineum

It contains among other things anthracene and phenol. Because of its rot-resisting and disinfecting effect, Carbolineum was ...

*Cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase

This enzyme participates in naphthalene and anthracene degradation. Nagao K, Takizawa N, Kiyahara H (1988). "Purification and ...

*Phenanthrenoid

This enzyme participates in naphthalene and anthracene degradation. (+)-Cavicularin, a cyclic bibenzyl-dihydrophenanthrene ...

*Benzene 1,2-dioxygenase

This enzyme participates in naphthalene and anthracene degradation. It has 4 cofactors: FAD, Iron, Sulfur, and Iron-sulfur. ...

*Salicylaldehyde dehydrogenase

This enzyme participates in naphthalene and anthracene degradation. Eaton RW, Chapman PJ (1992). "Bacterial metabolism of ...
9,10-Dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylic acid - chemical information, properties, structures, articles, patents and more chemical data.
The dimer, called dianthracene (or sometimes paranthracene), is connected by a pair of new carbon-carbon bonds, the result of the [4+4] cycloaddition. It reverts to anthracene thermally or with UV irradiation below 300 nm. The reversible dimerization and the photochromic properties of anthracenes are the basis of potential applications.[11] Substituted anthracene derivatives behave similarly. The reaction is affected by the presence of oxygen. In general, reduction of anthracene yields 9,10-dihydroanthracene (destroying the aromaticity of the center ring) rather than 1,4-dihydroanthracene (which would destroy the aromaticity of one of the terminal rings). This preference for reduction at the 9 and 10 positions is explained by the fact that aromatic stabilization energy is directly correlated with the number of conjugated pi bonds in an aromatic system. Since 9,10-dihydroanthracene in essence preserves two "benzene" rings (a total of 6 conjugated pi bonds), whereas the 1,4-isomer preserves only ...
A green approach for the electrochemical exfoliation of graphite to graphene is reported. After the exfoliation of graphite, the 9-anthracene carboxylate ion (ACA), which was used as an electrolyte, was adsorbed on the surface of graphene through noncovalent interaction. X-ray diffraction analysis confirms t Nanomaterials for Energy Conversion and Storage
The oxidative dehydrogenation of dihydroarenes catalyzed by 2,3-dichloro-5,6-dicyano-benzoquinone(DDQ) and NaNO2 with dioxygen is reported. The combination of DDQ and NaNO2 showed high efficiency and high selectivity, compared with other benzoquinones and anthraquinones, e.g., |99% conversion of 9,10-dihydroanthracene with 99% selectivity for anthracene can be obtained at 120 °C under 1.3 MPa O2 for 8 h. Excellent results were achieved in the oxidative dehydrogenation of variety of dihydroarenes.
You are viewing an interactive 3D depiction of the molecule anthra[2,1,9-def:6,5,10-def]diisoquinoline-1,3,8,10(2h,9h)-tetrone, 2,9-dimethyl- (C26H34N2O4) from the PQR.
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Summary of Facts and Submissions. I. The Appellant (Opponent) lodged an appeal against the interlocutory decision of the Opposition Division which found that the European patent No. 1 553 154 amended according to the then pending auxiliary request 1 met the requirements of the EPC.. II. Notice of opposition had been filed by the Appellant requesting revocation of the patent in suit in its entirety on the grounds of lack of novelty and inventive step (Article 100(a) EPC) and insufficient disclosure (Article 100(b) EPC). Inter alia the following documents were submitted in the opposition proceedings:. (1) EP-A-0 857 007,. (2) EP-A-1 009 044 and. (3) EP-A-1 167 488.. III. According to the Opposition Division, the specification of the patent-in-suit contained sufficient information to enable the skilled person to carry out the invention across the whole breadth of the claims. Contrary to the assertion of the opponent, the wording asymmetric anthracene derivative represented by the formula (2) gave ...
AS 602801 | JNK inhibitor | Bentamapimod | AS602801 | AS-602801 | CAS [848344-36-5] | Axon 2002 | Axon Ligand™ with >98% purity available from supplier Axon Medchem, prime source of life science reagents for your research
AEG 3482 | JNK inhibitor | AEG3482 | AEG-3482 | CAS [63735-71-7] | Axon 1291 | Axon Ligand™ with >99% purity available from supplier Axon Medchem, prime source of life science reagents for your research
CONTROLLED LABS - Blue GrowtH™ FAQ & Write up What is Blue GrowtH™ ? Key Attributes: - Serum GH level enhancement - Deeper, more
The influence of peptide sequence and Leu chirality in linear and cyclic peptides containing 3-[2-(9-anthryl)benzoxazol-5-yl]alanine on interaction with β-cyclodextrin were studied using fluorescence and NMR spectroscopy. The analysis of enthalpy-entropy compensation effect (α=1.05±0.02 and TΔS00=15.1±0.5 kJ mol−1) indicates that the entropic contribution connected with the solvent reorganization is the major factor governing the peptides-β-cyclodextrin complexation. Moreover, spatial orientation of guest-host molecule depends more than association constant on Leu residue configuration. However, the cyclization of the peptide chain substantially decrease the association constant with β-CD. An analysis of 2D NMR spectra reveals that inclusion complex is formed by penetration of cyclodextrin cavity from wider and narrow rims by anthryl group in the case of Box(Ant)-SPKL or anthryl and Leu residues for Box(Ant)-SPK(D)L analogue ...
The dimer is connected by two covalent bonds resulting from the [4+4] cycloaddition. The dimer reverts to anthracene thermally or with UV irradiation below 300 nm. The reversible bonding and photochromic properties of anthracenes are the basis of many potential applications using poly and monosubstituted anthracene derivatives. The reaction is sensitive to oxygen.. In most other reactions of anthracene, the central ring is also targeted, as it is the most highly reactive. Electrophilic substitution occurs at the "9" and "10" positions of the center ring, and oxidation of anthracene occurs readily, giving anthraquinone, C14H8O2 (below).. ...
anthracene-9-carbonyl chloride 16331-52-5 route of synthesis, anthracene-9-carbonyl chloride chemical synthesis methods, anthracene-9-carbonyl chloride synthetic routes ect.
Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E?N (1?10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, and preliminary structure?activity
Procedure 1.Add 2mL samples or standards [0(pure water), 5, 10, 25, 50, 80µg/2mL] solution into all prepared test tubes. 2.(In chemical hood) Use glass pipette and gently add 0.5mL 2% anthrone solution into each test tube. There will be two layers of this solution. The upper layer is anthrone and the lower layer is the sample/standard. Try not to disturb solution, because ethyl acetate is easy to vaporize. 3.(In chemical hood) Use glass pipette to add 5mL concentrated sulfuric acid into the tube gently. Put the tip of pipette into the bottom of lower layer. Concentrated sulfuric acid will vaporize ethyl acetate immediately if you drop this sulfuric acid on it. [SAFETY NOTES: sulfuric acid is highly hazardous (corrosive, irritant). Be sure to wear gloves and prevent direct contact.] (The test tube will be very hot after sulfuric acid is added. Hold the higher part of test tube to prevent burning your fingers) 4.(In chemical hood) Swirl gently and youll see the vaporization of ethyl acetate. ...
Acridina, C13H9N, es un compuesto orgánico y un compuesto heterocíclico del nitrógeno. Además, el término es utilizado para describir a los compuestos que contienen al compuesto tricíclico C13N. La acridina se obtiene a partir de los aceites de antraceno, compuesto con el que se halla relacionada estructuralmente, durante el proceso de destilación del alquitrán. Principalmente, se utiliza en la fabricación de colorantes. Número CAS Synthesis of Acridine-based DNA Bis-intercalating Agents Gerard P. Moloney, David P. Kelly, P. Mack Molecules 2001, 6, 230-243 [1] open source Varios autores (1910-1911). «Acridine». En Chisholm, Hugh. Encyclopædia Britannica. A Dictionary of Arts, Sciences, Literature, and General information (en inglés) (11.ª edición). Encyclopædia Britannica, Inc.; actualmente en dominio público. Harper 27s New Monthly Magazine, Vol. XLIV, No. 261, February 1872, Editor= 27s Scientific Record- Acridine%2C a New Anthracene Derivative, A magazine account (1872) of ...
ALPHA CHEMIKA is an ISO 9001:2000 certified manufacturer, supplier & exporter of ANTHRONE including all laboratory Chemicals, and offered to our clients at the best industry prices, Inquire us for more products details.
Name: CA Name: Anthracene Molecular Structure: Anthracene,CAS 120-12-7,178.23,C14H10 Anthracene,CAS 120-12-7,178.23,C14H10 Molecular Formula:C14H10 Molecular Weight: 178.23 CAS Registry Number: 120-12-7
Benz(a)anthracene-1,2-diol, 1,2-dihydro-, diacetate, trans- | C22H18O4 | CID 151652 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
17513-39-2 - MQEFUMUDBDZXHE-UHFFFAOYSA-N - Benz(a)anthracene-7(12H)-one, 12-hydroxy-12-methyl- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
In October 2011 the EU commission published a recommendation (2011/696/EU) on the definition of nanomaterials. Standardised and certified methodologies (which are essential for accurate material characterisation, comparison and categorisation) to accompany this recommendation are now in development. From the results of analysis by the non-standardised methods currently available, it is conceivable that the substance subject to registration could be considered as falling within the boundaries of the nanomaterial definition. ...
Gentaur molecular products has all kinds of products like :search , Nacala \ Anthracene \ 03030-62 for more molecular products just contact us
As the largest Anthracene manufacturer in china, UIV CHEM sales quality 3-Bromofluoranthene[13438-50-1] to customers all over the world.
As the largest Anthracene manufacturer in china, UIV CHEM sales quality 9,10-Dibromoanthracene[523-27-3] to customers all over the world.
0261]Blue-green to green light emission can be obtained, for example, by using a coumarin dye such as coumarin 30 or coumarin 6, bis[2-(2,4-difluorophenyl)pyridinato]picolinatokidium (abbreviation: FIrpic), bis(2-phenylpyridinato)acetylacetonatoiridium (abbreviation: Ir(ppy)2(acac)), or the like as a guest material and dispersing the guest material in a suitable host material. Further, blue-green to green light emission can be obtained by dispersing perylene or TBP, which are mentioned above, in a suitable host material at a high concentration of 5 wt % or more. Further alternatively, blue-green to green light emission can be obtained from a metal complex such as BAlq, Zn(BTZ)2, or bis(2-methyl-8-quinolinolato)chlorogallium (Ga(mq)2Cl). Further, a polymer such as poly(p-phenylenevinylene) may be used. Further, an anthracene derivative is preferable as a guest material of a blue-green to green light-emitting layer, as high light-emitting efficiency can be obtained when an anthracene derivative is ...
The structure-based design and synthesis of a novel series of c-Jun N-terminal kinase (JNK) inhibitors with selectivity against p38 is reported. The unique structure of 3,5-disubstituted quinolines (2) was developed from the previously reported 4-(2,7-phenanthrolin-9-yl)phenol (1). The X-ray crystal structure of 16a in JNK3 reveals an unexpected binding mode for this new scaffold with protein ...
29311-94-2 - SYZOCKFTUCTLFQ-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,4-bis((3-chloro-2-hydroxypropyl)amino)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Kumao Hamanoue; Kazuo Nakajima; Toshiharu Hidaka; Toshihiro Nakayama and Hiroshi Teranishi. Time-dependent Picosecond Transient Absorption Spectra of 9-Acetylanthracene, Benzophenone and Acridine in Solution.Laser Chem.1984, 4 287-295.. K Anderson; H Becker; LM Engelhardt; L Hansen and AH White. Molecular geometry and crystal structure of 9-acetylanthracene.Australian Journal of Chemistry.1984, 37 (6), 1337 - 1340.. ...
Benz(a)anthracene-6-methanol | C19H14O | CID 186994 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
2-(Pyrazol-5-yl)phenol 34810-67-8 MSDS report, 2-(Pyrazol-5-yl)phenol MSDS safety technical specifications search, 2-(Pyrazol-5-yl)phenol safety information specifications ect.
4-(pyrazol-1-ylmethyl)benzoic acid 160388-53-4 NMR spectrum, 4-(pyrazol-1-ylmethyl)benzoic acid H-NMR spectral analysis, 4-(pyrazol-1-ylmethyl)benzoic acid C-NMR spectral analysis ect.
Unique Host Functions of Coordination Nanocavities Surrounded by Anthracene RingsUnique Host Functions of Coordination Nanocavities Surrounded by Anthracene Rings ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
Sigma-Aldrich offers Sigma-D3254, 7,12-Dimethylbenz[a]anthracene for your research needs. Find product specific information including CAS, MSDS, protocols and references.
Synthesis How to make a great presentation in powerpoint novel sugar or azasugar analog anthra[1,2- d ] imidazole-6,dione derivatives and interesting evaluation.
A synthesis of the spirocyclopente-dione anthracene adduct, a precursor of the cyclopentenone prostaglandins has been reported. The synthesis involved a Diels-Alder reaction of anthracene and dimethyl fumarate to afford 3 followed by reduction, oxidation and esterification reactions to provide methyl ester anthracene adduct 8, which further converted to the the allylic alcohol (12). Then, Ring-Closing Metathesis (RCM) reaction afforded the cyclopentenol anthracene adduct, which after oxidation provided the spirocyclopente-dione anthracene adduct in good yields.
The pathophysiology of a traumatic brain injury (TBI) involves the dysfunction of the blood-brain barrier (BBB). The lumen of the BBB is lined with cerebrovascular endothelial cells (CVEC) that are ensheathed with perivascular astrocyte endfeet. We investigated the cellular response of human-astrocytes and human-CVEC following trauma in vitro. Astrocytes and CVEC were subjected to a concussive injury (CI; mechanical stretch), then assessed for markers of injury (monolayer retraction) and activation (mitogen-activated protein kinases (MAPK) phosphorylation). CI induces astrocyte monolayer retraction and activation, with predominant phosphorylation of JNK1/2 MAPK. Interfering with JNK1/2 activation (selective JNK inhibitors) reduces trauma-induced astrocyte retraction. On the contrary, CI does not induce CVEC retraction, however up-regulates CVEC pro-adhesive phenotype resulting in increased polymorphonuclear leukocyte (PMN) adhesion. These findings indicate that CI elicits differential BBB cell responses
The drug is not recommended for use in children. The possibility of suicide in seriously depressed patients is inherent in their illness and may persist until significant remission occurs. Therefore, patients must be carefully supervised during all phases of treatment with maprotiline and prescriptions should be written for the smallest amount consistent with good management. Safe use of Maprotiline during pregnancy or lactation has not been established; therefore, its use in pregnancy, in nursing mothers or in women of childbearing potential requires that the benefits of treatment be weighed against the possible risks to mother and child. Patients should be kept under medical surveillance during treatment with maprotiline. The dosage of maprotiline should be individualized according to the requirements of each patient. Do not share this medicine with others for whom it was not prescribed. Do not use this medicine for other health conditions. After you stop taking this medicine, your body will ...
Angiotensin II (ANG II) has been implicated in the pathogenesis of diabetic micro- and macrovascular disease. In vascular smooth muscle cells (VSMCs), ANG II phosphorylates and degrades insulin receptor substrate-1 (IRS-1). While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH2-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. We investigated the role of JNK in ANG II-induced IRS-1 phosphorylation, degradation, Akt activation, glucose uptake, and hypertrophic signaling, focusing on three IRS-1 phosphorylation sites: Ser302, Ser307, and Ser632. Maximal IRS-1 phosphorylation on Ser632 occurred at 5 min, on Ser307 at 30 min, and on Ser302 at 60 min. The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). However, JNK inhibition had no effect on ANG II-mediated IRS-1 degradation, nor did it reverse the ...
Angiotensin II (ANG II) has been implicated in the pathogenesis of diabetic micro- and macrovascular disease. In vascular smooth muscle cells (VSMCs), ANG II phosphorylates and degrades insulin receptor substrate-1 (IRS-1). While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH2-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. We investigated the role of JNK in ANG II-induced IRS-1 phosphorylation, degradation, Akt activation, glucose uptake, and hypertrophic signaling, focusing on three IRS-1 phosphorylation sites: Ser302, Ser307, and Ser632. Maximal IRS-1 phosphorylation on Ser632 occurred at 5 min, on Ser307 at 30 min, and on Ser302 at 60 min. The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). However, JNK inhibition had no effect on ANG II-mediated IRS-1 degradation, nor did it reverse the ...
Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix kaempferi Gorden, has antifungal activity. - Mechanism of Action & Protocol.
TheK i values of Cibacron blue, chrysin, 7,8-dihydroxyflavone, phenindone, and dicoumarol to rY128D, rG150V, and hH161Q were significantly greater than those for the wild-type human enzymes, indicating that Tyr128, Gly150, and His161 are situated in the binding pockets of these inhibitors. On the other hand, Tyr155 and His194 are probably not in direct contact with the inhibitors, because the binding of inhibitors are not affected by Tyr155 to Phe and His194 to Asp mutations.. The X-ray structure of Cibacron blue bound to rat DT-diaphorase has been published (Li et al., 1995) and was used to help interpret the results of our inhibition studies. The binding of Cibacron blue is significantly reduced by the Tyr128 to Asp mutation and the Gly150 to Val mutation. The K i values of Cibacron blue for rY128D and rG150V are 110 and 23 times that for the wild-type rat DT-diaphorase, respectively. The X-ray structural analysis revealed that the inhibitors trizaine ring is sandwiched between these two ...
The substance belongs to the category of perylene as indicated by its chemical core structure. Based on this structure and the chemical and biological stability of perylenes under environmental conditions data from structural analogue perylenes are used to support the results of the test substance for this endpoint. The changes in the respiration rate of activated sludge in presence of the analogue perylenes (CAS 4948-15-6, CAS 81-33-4, CAS 128-69-8) were investigated in three guideline studies according to OECD 209 and ISO 8192, respectively, with activated sludge as inoculum. At test termination after 30 minutes effect concentrations , 700 mg/L (nominal) were determined [BASF AG 1998; BASF AG 1999; BASF AG 1986]. Additionally, several oxygen consumption tests which were conducted according to ROBRA (DIN 38412, part 27) are available for the toxicity assessment. The bacteria Pseudomonas putida was exposed to different test concentrations of the following analogue substances: CAS 3049-71-6, CAS ...
0037] Mention may also be made, as pyrazole derivatives, of diamino-N,N-dihydropyrazolopyrazolones and in particular those described in application FR-A-2 886 136, such as the following compounds and the addition salts thereof: 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-ethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-isopropylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-(pyrrolidin-1-yl)-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-on- e, 4,5-diamino-1,2-dimethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-diethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-di(2-hydroxyethyl)-1,2-dihydropyrazol-3-one, 2-amino-3-(2-hydroxyethyl)amino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-- 1-one, 2-amino-3-dimethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-- one, 2,3-diamino-5,6,7,8-tetrahydro-1H,6H-pyridazino[1,2-a]pyrazol-1-one, 4-amino-1,2-diethyl-5-(pyrrolidin-1-yl)-1,2-dihydropyrazol-3-one, ...
This pill with imprint 6 0 M is White, Round and has been identified as Maprotiline hydrochloride 25 mg. It is supplied by Mylan Pharmaceuticals Inc..
Electron transfer reactions have been studied between 9-anthracenecarboxylic acid co-adsorbed with perylene on silica gel surfaces employing azulene as a molecular shuttle in order to facilitate hole transfer. In this paper we present for the first time a ternary system that unambiguously demonstrates an appreciable mobility of radical cations on the silica gel surface. Rates of hole transfer from the 9-anthracenecarboxylic acid radical cation to perylene via azulene have been studied using diffuse reflectance laser flash photolysis spectroscopy. Azulene has been shown to enhance the rate of electron transfer in the ternary system, proving significant mobility of the azulene and its radical cation species on silica gel surfaces. The data shows that the azulene radical cation can diffuse at an appreciable rate on the silica gel surface ...
In this work, magnetic functionality was introduced to cross-linked acrylamide-based particles via the in situ coprecipitation of iron oxide nanoparticles within the hydrogel particle interior. Cibacron Blue F3G-A was then incorporated onto the magnetic hydrogel scaffold to facilitate the harvest of targeted protein species. The dye-loaded magnetic particles were physically characterized, and their protein sequestration performance was investigated. The results of these studies indicated that dye-loaded magnetic particles sequestered a greater amount of lower molecular weight proteins from the test solution than was achieved using reference particles, dye-loaded cross-linked N-isopropylacrylamide-based core-shell particles. This difference in protein harvesting ability may reflect the higher degree of dye-loading in the magnetic particles relative to the dye-loaded core-shell particles.
Dibenz(a,h)anthracene has produced tumours by different routes of administration in mice, rats, guinea pigs, frogs, pigeons and chickens. It has both local and systemic carcinogenic effects.. On oral administration, it produced tumours of the forestomach in the mouse; intratracheal administration to rats produced lung tumours. In repeated skin painting experiments in mice, dibenz(a,h)anthracene and benzo(a)pyrene appeared to be equally effective. In a dose-response study on s.c. carcinogenicity with dibenz(a,h)anthracene, benzo(a)pyrene and 3-methylcholanthrene, dibenz(a,h)anthracene was shown to be effective at a lower dose than that effective for benzo(a)pyrene or for 3-methylcholanthrene; its latent period, however, was longer. Dibenz(a,h)anthracene induced local sarcomas and increased the incidence of lung adenomas following a single s.c. injection in newborn mice at dose levels which were ineffective with 3-methylcholanthrene. It has not been adequately tested in other species. ...
Dibenz[a,h]anthracene has been shown to be carcinogenic to experimental animals.. Dibenz[a,h]anthracene is embryotoxic to rats when given at high doses. The available data on teratogenicity were inadequate for evaluation. Dibenz[a,h]anthracene was positive in differential survival assays using DNA-repair-proficient/-deficient strains of bacteria and was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. In cultured mammalian cells, dibenz[a,h]anthracene was mutagenic and induced unscheduled DNA synthesis in the presence of an exogenous metabolic system. It was positive in assays for morphological transformation. In the one available study, it induced sister chromatid exchange but not chromosomal aberrations in vivo.. There is sufficient evidence that dibenz[a,h]anthracene is active in short-term tests. ...
Aceptado junio 2009. ABSTRACT. The aim of this study was to determine the effect of linear alkylbenzene sulfonate (LAS), anthracene and a LAS anthracene mixture on the growth of a microbial consortium isolated from polluted sediment. The microbial consortium was grown in a sterile glass bottle with mineral medium containing 1 g/L of glucose. Microbial growth inhibition produced by LAS, anthracene and combinations of LAS and anthracene was determined by viable count in nutritive agar; inhibitory concentration 50 (IC50) was calculated. The concentrations evaluated were 0.16, 0.8, 1.6, 16 and 160 mg/L of LAS or anthracene. The LAS anthracene mixtures were prepared by fixing either LAS or anthracene at 0.16 mg/L while increasing the other compound at the above concentrations. Microbial growth was sensitive to LAS at an IC50 of 8.22 and to anthracene at an IC50 of 5.2 mg/L. In the LAS anthracene combination, if LAS concentration was fixed and anthracene concentration varied, IC50 (5.92 mg/L) was ...
A recent study has shown that c-jun NH2-terminal kinase (JNK) activation modulates FLIPL degradation ( 15). We then determined whether celecoxib down-regulates c-FLIP through a JNK-dependent mechanism. Celecoxib indeed increased the levels of phosphorylated c-Jun (p-c-Jun), an indicator of JNK activation, and decreased the levels of both FLIPL and FLIPS. The JNK inhibitor SP600125 at concentrations up to 30 μmol/L abrogated celecoxib-induced c-Jun phosphorylation, but failed to block down-regulation of either FLIPL or FLIPS by celecoxib (Supplementary Fig. S1). Considering these findings and the fact that JNK does not modulate FLIPS turnover ( 15) whereas celecoxib down-regulates the levels of both FLIPL and FLIPS ( Fig. 1), we conclude that celecoxib induces a JNK-independent degradation of c-FLIP.. It is well known that celecoxib is a specific COX-2 inhibitor. However, many studies show that celecoxib induces apoptosis independent of COX-2 inhibitory activity ( 2). To determine whether ...
Before starting maprotiline, be sure to let your doctor know if youve recently had a heart attack. This eMedTV page offers other important precautions and warnings with maprotiline, including possible side effects that may occur.
Consumer information about the medication MAPROTILINE - ORAL (Ludiomil), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug MAPROTILINE - ORAL.
When medications like MAOIs or pressors are taken together with maprotiline, drug interactions may occur. This eMedTV page lists other medicines that may cause drug interactions with maprotiline and explains the risks involved with mixing medications.
The addition of both MEK1 inhibitor U0126 or JNK inhibitor SP600125 coupled with RI inhibitor SB431542 had no detectable result to the mesenchymal phenotype on the cells. The mixture these details of p38 MAPK inhibitor SB203580 and ROCK inhibitor Y27632 restored cortical actin stain ing, but tension fiber actin remained inside the cells. Escalating the concentration of RI inhibitor SB431542 to ten M led to a even more lessen from the level of anxiety fib ers, nonetheless, the combination of RI inhibitor SB431542 by using a p38 MAPK inhibitor SB203580 or ROCK inhibitor Y27632 was additional effective at getting rid of them. Related results were observed in wild variety mTEC cells, which has a mixture of RI inhibi tor SB431542 and ROCK inhibitor Y27632 reversing EMT as indicated by each gene expression and cell morphology. Collectively, these information indicate that therapy in the cells with RI inhibitor SB431542 by itself are unable to result in total re acqui selleck AZD4547 sition of cortical ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-),please inquire us for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-).
Home , News , About , Research , Patients , Initiatives , Editorials , Links , Contact. Disclaimer: The AMDA does not endorse any of the products, medications, treatments or information reported herein. The website and its contents is intended for informational purposes, only. We strongly advise that you discuss all medications, treatments, and/or products with your physician.. ...
Transformation of Functional Groups . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 81 81 87 90 92 93 93 95 95 97 98 98 99 100 101 101 101 101 102 102 103 105 106 112 113 114 115 116 116 118 121 122 124 124 124 125 125 126 128 130 132 132 133 133 133 134 Sec. A] 29 PYRAZOL-3-ONES. PART III I. Introduction The present article is Part III of a three part series. In Part I (01AHC(80)73) the synthesis and applications of pyrazol-3-ones I and II are described. G. Of Acyl or Imine Substituted Pyrazol-3-ones . . . . . . . . . . . H. With 1-(3-oxopyrazol-4-yl)-3-substituted Thioureas . . . . . . . . . X. Solvolysis . . . . . . . . . . . . . . . . . . . . . . . . . A. Of Carbonyl and Arylsulfonylpyrazol-3-ones . . . . . . . . . . . B. Of 4-(iminophenylmethyl or phenylaminomethylene)pyrazol-3-ones . . . C. Of (5-oxopyrazol-3-yl)acetamide or 4,4-(dimorpholin-4-yl)pyrazol-3-one . A. With Molecular Oxygen . . . . . . . . . . . . . . . . . . . B. With Bromine or ...
Buy Linopirdine dihydrochloride - an affordable, high quality Kv7 channel Blocker from Hello Bio, a trusted supplier for life science researchers worldwide
Name:C.I.Mordant Blue 32,C.I.58605 Molecular Structure: anthraquinones C.I.Mordant Blue 32,C.I.58605,CAS 6372-24-6,304.21,C14H8O8,Anthracene Navy Blue SWR C.I.Mordant Blue 32,C.I.58605,CAS 6372-24-6,304.21,C14H8O8,Anthracene Navy Blue SWR Molecular Formula:C14H8O8 Molecular Weight: 304.21 CAS Registry Number:6372-24-6
Here is another molecule of the year, on a topic close to my heart, the catenane systems 1 and the trefoil knot 2 Such topology is closely inter-twinned with
c-Jun N-terminal kinases (JNKs) participate in many physiologic and pathologic processes, including inflammatory diseases. In this study, the sodium salt of 11H[1,2-b]quinoxalin-11-one oxime (IQ-1S) was synthesized and shown to be a high-affinity JNK inhibitor. Molecular docking of the IQ-1S syn isomer into the JNK1 binding site gave the best pose, which corresponded to the position of cocrystallized JNK inhibitor SP600125 (1,9-pyrazoloanthrone). Evaluation of the therapeutic potential of IQ-1S showed that it inhibited matrix metalloproteinase 1 and 3 gene expression induced by interleukin-1β in human fibroblast-like synoviocytes, and significantly attenuated development of murine collagen-induced arthritis. Collagen II-specific antibody responses were also reduced by IQ-1S treatment. In addition, IQ-1S treatment suppressed proinflammatory cytokine and chemokine levels in joints and lymph node cells. Finally, treatment with IQ-1S increased the number of Foxp3+CD4+CD25+ regulatory T cells in ...
Abbrev Analyte Units* Method (95 only) acenphth Acenaphthene ug/kg SW8270/SIM acnphens acenaphthene-SIM ug/kg acnphyls acenaphthylene-SIM ug/kg ag Silver mg/kg SW7740 anthra Anthracene mg/kg anthras Anthracene-SIM ug/kg anthraug Anthracene ug/kg SW8270/SIM arohydr Aromatic Hydrocarbons mg/kg SW8270 as Arsenic mg/kg SW7060 benanthr Benzo(a)anthracene mg/kg benanths Benzo(a)anthracene-SIM ug/kg benflans Benzo(b)fluoranthene-SIM ug/kg benflant Benzo(b)fluoranthene mg/kg benzacid Benzoic acid mg/kg benzofls Benzo(k)fluoranthene-SIM ug/kg bisester Hexanedioic acid, bis(2-ethylhexyl) mg/kg SW8270 bismthno 1,2-Benzenedicarboxylic acid, bis(8 mg/kg SW8270 bisphth bis(2-Ethylhexyl)phthalate mg/kg bnzantug Benzo(a)anthracene ug/kg SW8270/SIM bnzbflug Benzo(b)fluoranthene ug/kg SW8270/SIM bnzkflug Benzo(k)fluoranthene ug/kg SW8270/SIM bnzprlug Benzo(g,h,i)perylene ug/kg SW8270/SIM bnzpyrug Benzo(a)pyrene ug/kg SW8270/SIM bperyl Benzo(g,h,i)perylene mg/kg bperyls Benzo(g-h-i)perylene-SIM ug/kg Abbrev ...
Cardiotoxicity from the antitumor anthracycline, doxorubicin, correlates with cardiac drug levels, redox activation, and formation of the metabolite doxorubicinol. The cardiotoxicity may first be observed during salvage therapy with other drugs such as the anthracenedione mitoxantrone. In contrast, less cardiac toxicity has been observed in patients treated with doxorubicin followed by the anthracenedione pixantrone. In doxorubicin-pretreated human myocardial strips, pixantrone or mitoxantrone did not alter levels of residual doxorubicin. Mitoxantrone showed an unchanged uptake but synergized with doxorubicin for more redox formation. In contrast, pixantrone uptake was reduced, lacked redox synergism with doxorubicin, and inhibited formation of doxorubicinol.. See article at J Pharmacol Exp Ther 2013, 344:467-478.. ...
Gentaur molecular products has all kinds of products like :search , PhytoTechnology Laboratories \ FOOD COLOR, BLUE \ F322-1G for more molecular products just contact us
3-Hydrazinoquinoxalin-2(1H)-one was prepared from quinoxaline-2,3-dione and subsequently used for the synthesis of some potentially biologically active 3-(pyrazol-1-yl)quinoxalin-2(1H)-one derivatives. While 3-(3,5-dimethylpyrazol-1-yl)quinoxalin-2(1H)-one showed a comparative effect with streptomycin, 3-(5-oxo-3-phenyl-4,5-di- hydropyrazol-1-yl)quinoxalin-2(1H)-one was found to be the most active with an MIC value of 7.8 μg/ml.. ...
anthraquinone: The most important quinone derivative of anthracene and the parent substance of a large class of dyes and pigments. It is prepared commercially by oxidation of anthracene or condensation...
oncocalyxone A: a 1,4-anthracenedione isolated from Auxemma oncocalyx (Boraginaceae) that has been shown to be cytotoxic to tumor cells in vitro
Buy Blue 12ft Cat5e Snagless Unshielded (UTP) Ethernet Patch Cable at FS. Best Oxgen-free Copper Cat5e RJ45 Network Patch Cable On Sale, Order Now!
Page contains details about giant cage catenane mesoporous assembly . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
In a similar manner and under identical conditions Scott and Kucera examined the effect of naphthalene over load (from 1.1 to 19.1 mg) on the retention of benzene, naphthalene and anthracene. The results are shown in figure 9.. ...
Parapoxvirus ovis (PPVO) is known for its immunostimulatory capacities and has been successfully used to generate vector vaccines effective especially in non-permissive host species. Murine conventional and plasmacytoid dendritic cells (cDC and pDC) are able to recognize PPVO. The PPVO-sensing receptor on pDC is hitherto unknown. In this study we aimed to define the pattern recognition receptor responsible for the activation of murine pDC by inactivated and replication-competent PPVO. We show that PPVO-induced expression of type I and type III interferons, pro-inflammatory cytokines, and co-stimulatory CD86 by bone marrow-derived pDC but not cDC is blocked by chloroquine, an inhibitor of endosomal maturation. The activation of pDC is independent of viral replication and depends mainly on TLR9. Moreover, the use of phosphatidylinositol 3-kinase inhibitor wortmannin or C-Jun-N-terminal kinase inhibitor SP600125 results in significant reduction of PPVO-induced pDC activation. Taken together, our data
Background. Anti-inflammatory and immunomodulatory activities have been reported for maprotiline, a strong norepinephrine reuptake inhibitor. In addition, some other antidepressant drugs have shown beneficial effects in experimental colitis. Methods. All the animals were divided into normal and depressed groups. In normal rats colitis was induced by instillation of 2 mL of 4% acetic acid and after 2 hours, maprotiline (10, 20, and 40 mg/kg, i.p.) was administered. In reserpinised depressed rats, depression was induced by injection of reserpine (6 mg/kg, i.p.), 1 h prior to colitis induction, and then treated with maprotiline (10, 20, and 40 mg/kg). Treatment continued daily for four days. Dexamethasone (1 mg/kg, i.p.) was given as a reference drug. On day five following colitis induction, animals were euthanized and distal colons were assessed macroscopically, histologically, and biochemically (assessment of myeloperoxidase activity). Results. Maprotiline significantly improved macroscopic and ...
Best-known and simplest of the condensed-ring hydrocarbons, naphthalene is a solid at room temperature. Like anthracene, also a solid at room temperature, it can be isolated from coal tar.. Products of both substances are used in the manufacture of dyestuffs and in the produc tion of plastics and polyester resins. These res ins are useful in the manufacture of paints, film, and synthetic fibers (polyester clothing). Certain compounds of naphthalene and an thracene, however, have been banned in many countries. An impurity present during the pro duction of these compounds has been found to cause cancer.. Further condensed hydrocarbons can be made by fusing rings together. They can be added together to form a chain of rings, or joined honeycomb-fashion. Many useful prod ucts are derived from fusing rings together.. Coal carbonization is the major source of anthracene, naphthalene, and most other con densed aromatics. In the absence of air, coal is heated to a temperature of about 1650 F. (900 C). ...
In order to research the function of galectin-3 in tumor angiogenesis associated with tumor-associated macrophages (TAM) and tumor parenchyma, the galectin-3 expression was reconstituted in Tm1 melanoma cell line that lacks this protein. amounts, no significant distinctions between WTG3, WTN3, KOG3 or KON3 had been discovered (Fig. T6). BMDM from galectin-3 KO pets portrayed higher amounts of Arginase 1 but had been insensitive to its modulation by Meters2 prototypical cytokines Structured on the elevated reflection of Arginase I in WTG3 tumors, as well as on the idea that tumor-associated macrophages are polarized to the protumorigenic Meters2 phenotype, we CDP323 tested the impact of galectin-3 interruption in this sensation following. Once galectin-3 is normally viewed as a essential molecule in this polarizing event 9, we examined the behavior of BMDM from both WT and KO rodents after in vitro enjoyment with IL-4 (50?ng/mL) or TGF50?ng/mL pro-M1 stimuli with or without addition of exogenous ...
Most individuals with mutant B-Raf melanomas respond to inhibitors of oncogenic B-Raf but resistance eventually emerges. autophagy may protect UI-152-treated cells from undergoing growth inhibition. Collectively, our data implicate high rates of autophagy as a important mechanism of acquired resistance to the oncogenic B-Raf inhibitor, in support of medical studies in which combination therapy with autophagy targeted medicines is definitely becoming designed to conquer resistance. melanoma models (Ahn to generate resistant derivatives of B-Raf (V600E) melanoma cell lines. This model cell collection was used to understand acquired resistance mechanisms after the initial response to UI-152. The present study implicates high rates of autophagy as a important mechanism of acquired resistance to the oncogenic B-Raf inhibitor. Moreover, our data suggest that inhibition of autophagy in combination with a selective Raf inhibitor gives a more effective restorative strategy for melanoma. MATERIALS AND ...
Eesti Teadusinfosüsteem koondab informatsiooni teadus- ja arendusasutuste, teadlaste, teadusprojektide ning erinevate teadustegevuste tulemuste kohta.
[ATTACH] Retigabine can be very dangerous. Do not take it unless prescribed by a physician. This thread is reserved for general discussion on...
Purpose: Pseudolaric acid B (PAB) is the major bioactive constituent in the root bark of Pseudolarix kaempferi that has been used as an antifungal remedy in traditional Chinese medicine. Previous studies showed that PAB exhibited substantial cytotoxicity. The aims of this study were to elucidate the molecular target of PAB, to examine its mechanism of action, and to evaluate the efficacy of this compound in vivo. Experimental Design: The effect of PAB on cell growth inhibition toward a panel of cancer cell lines was assayed. Cell cycle analysis, Western blotting, immunocytochemistry, and apoptosis analysis were carried out to examine the mechanism of action. Tubulin polymerization assays were conducted to examine the interaction between PAB and tubulin. A P-glycoprotein - overexpressing cell line was used to evaluate the efficacy of PAB toward multidrug-resistant phenotypes. In vivo efficacy of PAB was evaluated by the murine xenograft model. Results: PAB induces cell cycle arrest at G 2-M ...
A comparison was drawn between the action of Cibacron Blue F3GA on the enzymic activity of DNA-dependent RNA polymerases from different sources, e.g. Escherichia coli, calf thymus and wheat germ (polymerase II). Sensitivity towards this inhibitor was determined for polymer formation and primed abortive synthesis of trinucleotide UpApU. In case of E. coli polymerase and wheat germ polymerase II the dye inhibits both polymer formation and abortive synthesis. Calf thymus polymerase II is inhibited only in the polymerisation step. The primed initiation reaction was found to be resistant towards the dye. In case of E. coli polymerase and wheat germ polymerase II the sensitive step is the formation of internucleotide bond whereas in case of calf thymus polymerase II the translocation of the enzyme is influenced. An analysis of kinetic data indicates more than one binding site for the dye on RNA polymerase II from calf thymus and wheat germ. Cibacron blue does not inhibit specific transcription ...
Definition of maprotiline in US English - A tetracyclic antidepressant with properties similar to those of tricyclic amitriptyline, usually administered orally as
A number of reactive dichlorotriazine dyes specifically and irreversibly inactivate pig heart lactate dehydrogenase, yeast glucose 6-phosphate dehydrogenase and yeast hexokinase at sites competitive with NAD+, NADP+, and ATP respectively. Monochlorotriazine dyes, including Cibacron Blue F3G-A, do not inactivate lactate dehydrogenase but display high affinity and thus inhibit the inactivation by dichlorotriazine dyes. These data are interpreted in terms of the ability of nucleotide-binding enzymes to bind polysulphonated aromatic chromophores.. ...
Luchini A, Longo C, Espina V, Petricoin EF III and Liotta LA, Nanoparticle Technology: Addressing the fundamental roadblocks to protein biomarker discovery, Journal of Materials Chemistry, in press. Longo C, Patanarut A, Bishop B, Zhou W, Ross MM, Espina VE, Pellacani G, Petricoin EF III, Liotta LA, Luchini A, Core-Shell Hydrogel Particles Harvest, Concentrate and Preserve Labile Low Abundance Biomarkers, PLoS ONE, (2009), Volume 4, Issue 3, e4763.. Fredolini C, Meani F, Reeder KA, Rucker S, Patanarut A, Botterell PJ, Bishop B, Longo C, Espina V, Petricoin, EF III, Liotta LA, and Luchini A. Concentration and Preservation of Very Low Abundance Biomarkers in Urine, such as Human Growth Hormone (hGH), by Cibacron Blue F3G-A Loaded Hydrogel Particles Nano Research, (2008) 1: 502 518.. Luchini A, Long DP, Vaisman I, Petricoin EF, Geho D, Liotta LA. Phosphorylation-induced conformational change alters electron transport in peptide molecular junctions, Research Letters Nanotechnology, Volume 2008 ...
Poly(HEMA) cryogel disks were synthesized by free radical polymerization of 2-hydroxy-ethylmethacrylate (HEMA), and then Cibacron Blue F3GA (CB), Reactive Green 19 (RG) and Congo Red (CR) were immobilized as dye ligands. Disks were...
A description is given of the kinetics of the prompt and delayed luminescence components from aromatic materials excited by ionizing radiation. A theoretical model has been developed to describe the origin of the delayed scintillation component. From initial assumptions of molecular triplet state diffusion and triplet-triplet annihilation to form delayed singlet states, equations are obtained defining the intensity of the delayed component with time. These equations are shown to agree well with existing experimental results. From the comparison the following parameters for triplet excitations in anthracene and stilbene crystals have been calculated: diffusion constant, 6 x 10-6 cm2 s-1 (anthracene) and 3 x 10-6 cm2 s-1 (stilbene); triplet-triplet interaction rate constant, 1·3 x 10-11 cm3 s-1 (anthracene) and 7·5 x 10-12 cm3 s-1 (stilbene); and diffusion length, 3·5 x 10-4 cm (anthracene). ...
Hello everyone. My name is Jill, and I have a story to tell about my amazing and fearless son, Thomas. Thomas was born on Sept. 6, 2002. His trip was less then smooth. Although he looked like a beautiful and healthy 10lb 9oz baby boy, he had some problems with his heart being enlarged. On day one, before I had a chance to hold him, he would take his first flight to the local trauma where he would spend the next 10 days fighting to breath on his own. Doctors had no direct answers to what may have happened, but they assured me that he was going to be okay. The day he came home for the first time was wonderful. I hadnt been able to hold him a whole lot in the PICU so I was making up for lost time.. Every thing seemed great. He was almost 2 months old when he got a bad cold that wouldnt go away. After a few stops at our doctors, they decided to put Thomas back in the hospital. That evening he would take his second flight and visit his good friends at the trauma center again. He was tested for many ...
A phytochemical investigation of the leaf exudate of Aloe marlothii has resulted in the isolation of a new chromone (7-O-methylaloeresin A) and a new anthrone (5-hydroxyaloin A 6-O-acetate). Furthermore 7-O-methylaloesin was isolated as a natural pr
광여기된 안트라센은 N,N-dimethylaniline(DMA)과 같은 기저 상태의 전자주개와 안정한 착물인 excited complex(exciplex)를 형성하는 것으로 잘 알려져 있다. 본 연구에서는 exciplex 형성 및 분해 반응에 미치는 전자주개의 구조적인 영향을 알아보기 위해 DMA 유도체인 N,N-dimethyl-o-toluidine(DMOT), N,N-dimethyl-m-toluidine(DMMT), N,N-dimethyl-p-toluidine(DMPT), 4-tert-butyl-dimethylaniline(BDMA), N,N,2,4,6-pentamethylaniline(PMA) 등을 사용하였다. 측정 방법으로는 absorption과 emission 및 time resolved spectroscopy를 이용하였다. DMA 페닐 링의 meta나 para 위치 치환은 안트라센과의 exciplex 형성에 영향을 미치지 않았다. 특히 para위치에 tertiary 부틸기가 붙은 BDMA는 메틸 기가 붙은 DMPT와 비슷한 결과를 보여 para 위치에 치환된 그룹의 크기는 exciplex 형성에 큰 영향을 주지 않음을 알 수 있었다. 이와 달리, ortho 위치의 치환은 ...
LAKSHIMI KESARI A. , CHELLAM V. G. , Beela Sarah Mathew , KRISHNAN NAIR M. , RADHAKRISHNA PILLAI M. Breast cancer : the journal of the Japanese Breast Cancer Society 6(1), 29-36, 1999-01-25 参考文献20件 被引用文献1件 ...
c-Jun兔多克隆抗体(ab428)可与鸡, 哺乳动物样本反应并经WB, EMSA实验严格验证,被6篇文献引用。所有产品均提供质保服务,中国75%以上现货。
Maprotiline (Ludiomil) is a tetracyclic antidepressant introduced in the early 1980s. It is a norepinephrine reuptake inhibitor, which is believed to be its primary mechanism of antidepressant action. It had a particularly high incidence of seizures, which the manufacturer initially minimized. Today maprotiline is seldom prescribed.. Initial advertising for maprotiline featured the headline, "When Mechanism Matters." Perhaps the people who wrote the ad copy were banking on the Emperors-New-Clothes phenomenon: doctors would be too embarrassed to admit we didnt know when mechanism mattered in selecting an antidepressant for a depressed patient. We still dont.. We make assumptions. SSRIs work by enhancing serotonin. SNRIs work via both serotonin and norepinephrine. MAOIs work by inhibiting MAO. Perhaps these theories are valid; perhaps not. In theory, a patient who fails to respond to one SSRI should do better with a drug with a different mechanism of action, rather than a different SSRI. But ...
A 6-page summary of a 36 page guideline developed by an interprofessional group for use with long-term care residents who have developed an acute change in cognitive status or who have acutely developed problematic behavior. The full text guideline is available from the American Medical Directors Association (AMDA) for a fee. The summary is available through the National Guideline Clearinghouse located at: www.guidelines.gov.. NCLOR Learning Object: https://www.nclor.org/nclorprod/items/52627c7c-3d28-4ccb-af4d-066836cc18.... ...
Pretreatment of rats with benzo(α)pyrene, 3-methylcholanthrene, or 7,12-dimethylbenz(α)anthracene p.o. once daily for two days prior to the i.v. administration of tritiated benzo(α)-pyrene (BP-3H) on the third day stimulates the disappearance of BP-3H from blood and decreases the concentration of BP-3H in various tissues. Pretreatment of rats with pyrene, anthracene, or phenobarbital does not stimulate the in vivo disappearance of BP-3H. The concentration of BP-3H in the fat of rats is lower after seven daily p.o. doses of BP-3H than after a single dose of BP-3H, which suggests that this hydrocarbon stimulates its own metabolism during chronic administration.. ...
Lu, Jinzhen, Turner, David R., Harding, Lindsay P., Byrne, Lindsay T., Baker, Murray V. and Batten, Stuart R. (2009) Octapi Interactions: Self-Assembly of a Pd-Based [2]Catenane Driven by Eightfold π Interactions. Journal of the American Chemical Society, 131 (30). pp. 10372-10373. ISSN 1520-5126 Metadata only available from this repository ...
4-(1H-Imidazol-4-yl)-1-isopropyl-piperidine/ACM106243452 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Learn more about 2-3-4-dichlorobenzyl-sulfanyl-1-methyl-1h-imidazol-5-yl-methanol. We enable science by offering product choice, services, process excellence and our people make it happen.
Learn more about n-1h-imidazol-4-ylmethyl-n-methylamine. We enable science by offering product choice, services, process excellence and our people make it happen.
To compensate for this lack of enzymes, dogs slow the digestive process down significantly to try to "catch up" by producing their own enzymes or stealing enzymes from other organs to help with digestion. Not only does this stress the dogs system, but crucially it also allows the food to putrify as it is going through the digestive tract. Toxins from this putrified leach into the dogs system and are responsible for many ailments. They may manifest as "allergies", "irritable bowel" or other short-term complaint and also contribute to long-term diseases ...
... Published by 9Dimen Research at researchbeam.com . Global 9-anthracene aldehyde Industry 2015 Market Research Report report is a research report covering regions North America, Europe & Asia.

AnthraceneAnthracene

Other names: Anthracin; Green Oil; Paranaphthalene; Tetra Olive N2G; Anthracene oil; p-Naphthalene; Anthracen; Coal tar pitch ...
more infohttps://webbook.nist.gov/cgi/inchi/InChI%3D1S/C14H10/c1-2-6-12-10-14-8-4-3-7-13

ICSC 0825 -    ANTHRACENEICSC 0825 - ANTHRACENE

All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material ...
more infohttp://www.ilo.org/dyn/icsc/showcard.display?p_card_id=0825&p_version=1&p_lang=en

Anthracene - New World EncyclopediaAnthracene - New World Encyclopedia

Anthracene is an organic semiconductor.. Anthracene is used as a scintillator for detectors of high energy photons, electrons ... NIST Chemistry WebBook Anthracene. Credits. New World Encyclopedia writers and editors rewrote and completed the Wikipedia ... Anthracene is used in the artificial production of the red dye alizarin. It is also used in wood preservatives, insecticides, ... Anthracene has the ability to photodimerize with irradiation by UV light. This results in considerable changes in the physical ...
more infohttp://www.newworldencyclopedia.org/entry/Anthracene

Anthracene 10551-EAnthracene 10551-E

Intermediate For dyes, in manufacture of anthraquinone, in production of plastics & fibers, diluent for wood preservatives, scintillation counter crystals, organic semiconductor research, occurs in coal tar, smoked food (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.. ...
more infohttps://ntp.niehs.nih.gov/testing/status/agents/ts-10551-e.html

Anthracene - WikipediaAnthracene - Wikipedia

Anthracene is used in the production of the red dye alizarin and other dyes. Anthracene is colorless but exhibits a blue (400- ... The anthracene tracer allows the conformal coating to be inspected under UV light. Anthracene is one of the three components ( ... Reduction of anthracene with alkali metals yields the deeply colored radical anion salts M+[anthracene]− (M = Li, Na, K). ... Anthracene also reacts with dienophile singlet oxygen in a [4+2]-cycloaddition (Diels-Alder reaction): Anthracene is converted ...
more infohttps://en.wikipedia.org/wiki/Anthracene

Anthracene oil - Substance Information - ECHAAnthracene oil - Substance Information - ECHA

Anthracene oil. A complex combination of polycyclic aromatic hydrocarbons obtained from coal tar having an approximate ... Anthracene oil A complex combination of polycyclic aromatic hydrocarbons obtained from coal tar having an approximate ... anthracene and carbazole.] A complex combination of polycyclic aromatic hydrocarbons obtained from coal tar having an ... approximate distillation range of 300°C to 400°C (572°F to 752°F). Composed primarily of phenanthrene, anthracene and carbazole ...
more infohttps://echa.europa.eu/it/substance-information/-/substanceinfo/100.084.153

Anthracenes | Profiles RNSAnthracenes | Profiles RNS

"Anthracenes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Anthracenes" by people in this website by year, and whether " ... Below are the most recent publications written about "Anthracenes" by people in Profiles. ...
more infohttps://profiles.umassmed.edu/display/129127

Benz[a]anthracene - Substance Information - ECHABenz[a]anthracene - Substance Information - ECHA

Benz[a]anthracene. Regulatory process names 2 Translated names 18 IUPAC names 3 Other names 1 Other identifiers 2 ...
more infohttps://echa.europa.eu/es/substance-information/-/substanceinfo/100.000.255

Benz(a)anthracene - WikipediaBenz(a)anthracene - Wikipedia

Benz[a]anthracene or benzo[a]anthracene is a polycyclic aromatic hydrocarbon with the chemical formula C18H12. In February 2014 ... Benz(a)anthracene is a constituent of tobacco smoke. Tetracene, also known as benz[b]anthracene Nomenclature of Organic ... anthracene, in the universe. According to scientists, more than 20% of the carbon in the universe may be associated with PAHs, ...
more infohttps://en.wikipedia.org/wiki/Benz(a)anthracene

The Diels-Alder Reaction of Anthracene with Maleic Anhydride | BartlebyThe Diels-Alder Reaction of Anthracene with Maleic Anhydride | Bartleby

The Diels-Alder Reaction of Anthracene with Maleic Anhydride 1 The Diels-Alder Reaction of Anthracene with Maleic Anhydride ... The Diels-Alder Reaction of Anthracene with Maleic Anhydride 1 The Diels-Alder Reaction of Anthracene with Maleic Anhydride ... Anthracene was the diene and maleic anhydride was the dienophile. The percent yield of the crude product was 69.03%. Following ... More about The Diels-Alder Reaction of Anthracene with Maleic Anhydride. * Reactions And Reactions Of Redox Reactions. 2214 ...
more infohttps://www.bartleby.com/essay/The-Diels-Alder-Reaction-of-Anthracene-with-PKPHTJE36YYS

DIBENZ (a.j) ANTHRACENE (purity)DIBENZ (a.j) ANTHRACENE (purity)

ANTHRACENE (purity) from LGC Standards. Please login or register to view prices, check availability and place orders. ... 1-METHYLBENZ (a) ANTHRACENE (purity). 10 mg. BCR-093R. Add to basket ...
more infohttps://www.lgcstandards.com/DE/en/DIBENZ-a-j-ANTHRACENE-purity-/p/BCR-095

8-amino-9,10-dioxo-anthracene-1-sulfonic acid8-amino-9,10-dioxo-anthracene-1-sulfonic acid

... anthracene-1-sulfonic acid more infohttps://scitoys.com/scichem/jqp065/88943.html

Dibenz[a,h]anthracene (IARC Summary & Evaluation, Volume 32, 1983)Dibenz[a,h]anthracene (IARC Summary & Evaluation, Volume 32, 1983)

DIBENZ[a,h]ANTHRACENE. VOL.: 32 (1983) (p. 299) CAS No.: 53-70-3. Chem. Abstr. Name: Dibenz(a,h)anthracene. 5. Summary of Data ... There is sufficient evidence that dibenz[a,h]anthracene is active in short-term tests. 5.2 Human data. Dibenz[a,h]anthracene is ... Dibenz[a,h]anthracene has been shown to be carcinogenic to experimental animals.. Dibenz[a,h]anthracene is embryotoxic to rats ... 1,2:5,6-Dibenz(a)anthracene * 1,2,7,8-Dibenzanthracene * 1,2:5,6-Dibenzoanthracene * Dibenzo[a,h]anthracene Last updated: 17 ...
more infohttp://inchem.org/documents/iarc/vol32/dibenz%5Ba,h%5Danthracene.html

Dibenz(a,h)Anthracene (IARC Summary & Evaluation, Volume 3, 1973)Dibenz(a,h)Anthracene (IARC Summary & Evaluation, Volume 3, 1973)

DIBENZ(a,h)ANTHRACENE. VOL.: 3 (1973) (p. 178) 5. Summary of Data Reported and Evaluation. 5.1 Animal carcinogenicity data. ... In a dose-response study on s.c. carcinogenicity with dibenz(a,h)anthracene, benzo(a)pyrene and 3-methylcholanthrene, dibenz(a, ... In repeated skin painting experiments in mice, dibenz(a,h)anthracene and benzo(a)pyrene appeared to be equally effective. ... Dibenz(a,h)anthracene induced local sarcomas and increased the incidence of lung adenomas following a single s.c. injection in ...
more infohttp://inchem.org/documents/iarc/vol03/dibenz

Canary Database: Browse by Exposure: anthraceneCanary Database: Browse by Exposure: anthracene

Browse by Exposure: anthracene (5 articles). % of records by year: 1965 2017 ...
more infohttp://canarydatabase.org/browse/exposure/3162

Photochemical Techniques and the Photodimerization of Anthracene and Related Compounds | SpringerLinkPhotochemical Techniques and the Photodimerization of Anthracene and Related Compounds | SpringerLink

Cowan D.O., Drisko R.L. (1976) Photochemical Techniques and the Photodimerization of Anthracene and Related Compounds. In: ... In answering these questions we will be concerned mainly with the photochemistry of anthracene and related compounds. ...
more infohttps://link.springer.com/chapter/10.1007/978-1-4684-2130-9_2

Anthracene oil | ZanranAnthracene oil | Zanran

Anthracene oil, anthracene paste, carbazole fraction; Anthracene oil fraction, Anthracene oil, anthracene-low; Anthracene oil ... fraction, Anthracene oil, anthracene paste, carbazole fraction; Anthracene oil fraction... ... Anthracene oil Anthracene oil, anthracene paste, anthracene fraction Anthracene oil, anthracene-low Anthracene oil, anthracene ... J, M Anthracene oil, anthracene-low; Anthracene oil fraction (The oil remaining .... (anthracene paste) from anthracene oil. It ...
more infohttp://www.zanran.com/q/Anthracene_oil

9,10-(Divinyl) Anthracene Based Bright Aggregation-Induced Emissi...: Ingenta Connect9,10-(Divinyl) Anthracene Based Bright Aggregation-Induced Emissi...: Ingenta Connect

9,10-(Divinyl) Anthracene Based Bright Aggregation-Induced Emission Organic Dots for HeLa Cells Imaging ... By encapsulating AIE molecule 9,10-divinyl anthracene (DSA) with poly(styrene-co-maleic anhydride) and poly(isobutylene-alt- ...
more infohttps://www.ingentaconnect.com/contentone/asp/jnn/2020/00000020/00000004/art00010

Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles - Polymer Chemistry (RSC Publishing)Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles - Polymer Chemistry (RSC Publishing)

An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous ... Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles Y. Shi, R. M. Cardoso, C. F. van Nostrum and ... An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous ...
more infohttps://pubs.rsc.org/en/Content/ArticleLanding/2015/PY/C4PY01759E

Chemical Summary for Dibenz(a,h)anthraceneChemical Summary for Dibenz(a,h)anthracene

53-70-3 (CAS number); 53703 (CAS number without hyphens); Dibenz [a,h ]anthracene (under Polycyclic Aromatic Hydrocarbons,15 ...
more infohttp://www.pesticideinfo.org/Summary_Chemical.jsp?Rec_Id=PC42472

9,10-dioxo-N-(2,3,4-trifluorophenyl)anthracene-2-sulfonamide9,10-dioxo-N-(2,3,4-trifluorophenyl)anthracene-2-sulfonamide

Alfa Aesar™ 9-Bromo-10-(1-naphthyl)anthracene, 98%Alfa Aesar™ 9-Bromo-10-(1-naphthyl)anthracene, 98%

9-bromo-10-naphthalen-1-yl anthracene, 9-bromo-10-1-naphthalenyl anthracene, 9-bromo-10-1-naphthyl anthracene, anthracene, 9- ... 9-bromo-10-naphthalen-1-yl anthracene, 9-bromo-10-1-naphthalenyl anthracene, 9-bromo-10-1-naphthyl anthracene, anthracene, 9- ... 9-bromo-10-naphthalen-1-yl-anthracene, 10-bromo-9-phthalen-1-yl anthracene, 10-bromo-9-naphthalen-1-yl anthracene, 9-bromo-10-1 ... 9-bromo-10-naphthalen-1-yl-anthracene, 10-bromo-9-phthalen-1-yl anthracene, 10-bromo-9-naphthalen-1-yl anthracene, 9-bromo-10-1 ...
more infohttps://www.fishersci.ca/shop/products/9-bromo-10-1-naphthyl-anthracene-98-1/AAH6402406

7-Nitro benz(a)anthracene supplier | CasNO.20268-51-37-Nitro benz(a)anthracene supplier | CasNO.20268-51-3

... anthracene including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, ... Find quality suppliers and manufacturers of 7-Nitro benz(a)anthracenefor price inquiry.where to buy 7-Nitro benz(a)anthracene. ... 7-Nitro benz(a)anthracene Chemical Properties. Molecular Structure of 7-Nitro benz(a)anthracene (CAS NO.20268-51-3): IUPAC Name ... anthracene(100μg/mL in toluene) ; Benz(a)anthracene, 7-nitro- ... 7-Nitro benz(a)anthracene. EINECS CAS No. 20268-51-3 Density ...
more infohttps://www.lookchem.com/7-Nitro-benz-a-anthracene/

9-AC - anthracene-9-carboxylic acid | AcronymAttic9-AC - anthracene-9-carboxylic acid | AcronymAttic

9-AC stands for anthracene-9-carboxylic acid. 9-AC is defined as anthracene-9-carboxylic acid rarely. ... 9-AC: anthracene-9-carboxylic acid. AIP: autocamtide 2-related inhibitory peptide. BTS: N-benzyl-p-toluene sulfonamide. CaMKII ... n.d.) Acronym Attic. (2019). Retrieved July 17 2019 from https://www.acronymattic.com/anthracene_9_carboxylic-acid-(9_AC).html ... S.v. "9-AC." Retrieved July 17 2019 from https://www.acronymattic.com/anthracene_9_carboxylic-acid-(9_AC).html ...
more infohttps://www.acronymattic.com/anthracene_9_carboxylic-acid-

ANTHRACENE OIL (CAS 65996-91-0) Market Research Report 2018ANTHRACENE OIL (CAS 65996-91-0) Market Research Report 2018

Market Research Report 2018 aims at providing comprehensive data on anthracene oil market globally and regionally (Europe, ... 6. ANTHRACENE OIL MARKET PRICES. 6.1. Anthracene oil prices in Europe. 6.2. Anthracene oil prices in Asia 6.3. Anthracene oil ... Anthracene oil prices in other regions. 7. ANTHRACENE OIL END-USE SECTOR 7.1. Anthracene oil market by application sphere. 7.2 ... Anthracene oil application spheres, downstream products. 3. ANTHRACENE OIL MANUFACTURING METHODS. 4. ANTHRACENE OIL PATENTS. ...
more infohttps://marketpublishers.com/report/industry/chemicals_petrochemicals/anthracene_oil_65996-91-0_market_research_report.html
  • Asia-Pacific is expected to continue its domination and is also expected to be fastest growing market for the anthracene during the period of study due to increasing demand for anthracene in various end-use industries such as textiles and chemicals in major countries such as China, India and many others. (industryarc.com)
  • Identification and quantitation of 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse skin. (nih.gov)
  • Identification and quantitation of the depurination and stable DNA adducts of 7,12-dimethylbenz[a]anthracene (DMBA) formed by cytochrome P450 in rat liver microsomes previously established one-electron oxidation as the predominant mechanism of activation of DMBA to bind to DNA. (nih.gov)
  • This graph shows the total number of publications written about "Anthracenes" by people in this website by year, and whether "Anthracenes" was a major or minor topic of these publications. (umassmed.edu)
  • This report identifies all the major companies operating in the global anthracene market. (industryarc.com)
  • This report identifies the anthracene market size in for the year 2014-2016, and forecast of the same for year 2021. (industryarc.com)
  • ANTHRACENE OIL (CAS 65996-91-0) Market Research Report 2018 contents were worked out and placed on the website in January, 2018. (marketpublishers.com)
  • It also highlights the potential growth opportunities in the coming years, while also reviewing the market drivers, restraints, growth indicators, challenges, market dynamics, competitive landscape, and other key aspects with respect to anthracene market. (industryarc.com)