AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Benz(a)AnthracenesAnthracenes9,10-Dimethyl-1,2-benzanthraceneCarcinogensPapillomaMammary Neoplasms, ExperimentalPolycyclic CompoundsCocarcinogenesisSkin NeoplasmsMice, Inbred SENCARPolycyclic Hydrocarbons, AromaticBenzopyrenesBenzo(a)pyreneMucoralesPhenanthrenesBiotransformationCheekMethylcholanthreneChrysenesEthers, CyclicAnticarcinogenic AgentsNeoplasms, ExperimentalMammary Glands, AnimalMutagensMethylnitrosoureaTetradecanoylphorbol AcetateEpoxy CompoundsBiodegradation, EnvironmentalMesocricetusEpoxide HydrolasesCyclohexenesDNA AdductsMutagenicity TestsSkinCroton OilSoil PollutantsMicrosomes, LiverChromatography, Thin LayerChromatography, High Pressure LiquidCell Transformation, NeoplasticMoringa oleiferaTracheal NeoplasmsSpectrophotometry, UltravioletAryl Hydrocarbon HydroxylasesEpidermisMethylophilusRats, Inbred StrainsBrominePyrenesStereoisomerismHydrocarbonsAnthraquinonesCreosoteMouth NeoplasmsCricetinaeAdenofibromaEnzyme InductionChlorodiphenyl (54% Chlorine)AroclorsStructure-Activity RelationshipVinyl CompoundsDNA
Benz(a)Anthracenes
Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
Anthracenes
A group of compounds with three aromatic rings joined in linear arrangement.
9,10-Dimethyl-1,2-benzanthracene
7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
Mammary Neoplasms, Experimental
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
Polycyclic Compounds
Compounds consisting of two or more fused ring structures.
Cocarcinogenesis
The combination of two or more different factors in the production of cancer.
Skin Neoplasms
Tumors or cancer of the SKIN.
Mice, Inbred SENCAR
Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.
Polycyclic Hydrocarbons, Aromatic
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Benzopyrenes
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Benzo(a)pyrene
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
Mucorales
An order of zygomycetous fungi, usually saprophytic, causing damage to food in storage, but which may cause respiratory infection or MUCORMYCOSIS in persons suffering from other debilitating diseases.
Phenanthrenes
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Cheek
The part of the face that is below the eye and to the side of the nose and mouth.
Methylcholanthrene
A carcinogen that is often used in experimental cancer studies.
Chrysenes
1,2-Benzphenanthrenes. POLYCYCLIC COMPOUNDS obtained from coal tar.
Ethers, Cyclic
Compounds of the general formula R-O-R arranged in a ring or crown formation.
Anticarcinogenic Agents
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
Neoplasms, Experimental
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Mammary Glands, Animal
MAMMARY GLANDS in the non-human MAMMALS.
Mutagens
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Methylnitrosourea
A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
Tetradecanoylphorbol Acetate
A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
Epoxy Compounds
Organic compounds that include a cyclic ether with three ring atoms in their structure. They are commonly used as precursors for POLYMERS such as EPOXY RESINS.
Biodegradation, Environmental
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Mesocricetus
A genus of the family Muridae having three species. The present domesticated strains were developed from individuals brought from Syria. They are widely used in biomedical research.
Epoxide Hydrolases
Enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively.
Cyclohexenes
Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.
DNA Adducts
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Mutagenicity Tests
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
Skin
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Croton Oil
Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.
Soil Pollutants
Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.
Microsomes, Liver
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Chromatography, Thin Layer
Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Chromatography, High Pressure Liquid
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Cell Transformation, Neoplastic
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Moringa oleifera
A plant species of the family Moringaceae, order Capparales, subclass Dilleniidae. It is a source of niaziminin and hypotensive thiocarbamate glycosides.
Tracheal Neoplasms
Spectrophotometry, Ultraviolet
Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Aryl Hydrocarbon Hydroxylases
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Epidermis
The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
Methylophilus
A genus of straight or slightly curved gram-negative rods occurring singly or in pairs and isolated from sludge, mud, and river and pond water. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Rats, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Bromine
A halogen with the atomic symbol Br, atomic number 36, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.
Pyrenes
A group of condensed ring hydrocarbons.
Stereoisomerism
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Hydrocarbons
Anthraquinones
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
Creosote
A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.
Mouth Neoplasms
Tumors or cancer of the MOUTH.
Cricetinae
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Adenofibroma
A benign neoplasm composed of glandular and fibrous tissues, with a relatively large proportion of glands. (Stedman, 25th ed)
Enzyme Induction
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Chlorodiphenyl (54% Chlorine)
Aroclors
Industrial chemicals which have become widespread environmental pollutants. Each aroclor is a mixture of chlorinated biphenyls (1200 series) or chlorinated terphenyls (5400 series) or a combination of both (4400 series).
Structure-Activity Relationship
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Vinyl Compounds
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (1/915)

Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators.  (+info)

Formation of bound residues during microbial degradation of [14C]anthracene in soil. (2/915)

Carbon partitioning and residue formation during microbial degradation of polycyclic aromatic hydrocarbons (PAH) in soil and soil-compost mixtures were examined by using [14C]anthracenes labeled at different positions. In native soil 43.8% of [9-14C]anthracene was mineralized by the autochthonous microflora and 45.4% was transformed into bound residues within 176 days. Addition of compost increased the metabolism (67.2% of the anthracene was mineralized) and decreased the residue formation (20. 7% of the anthracene was transformed). Thus, the higher organic carbon content after compost was added did not increase the level of residue formation. [14C]anthracene labeled at position 1,2,3,4,4a,5a was metabolized more rapidly and resulted in formation of higher levels of residues (28.5%) by the soil-compost mixture than [14C]anthracene radiolabeled at position C-9 (20.7%). Two phases of residue formation were observed in the experiments. In the first phase the original compound was sequestered in the soil, as indicated by its limited extractability. In the second phase metabolites were incorporated into humic substances after microbial degradation of the PAH (biogenic residue formation). PAH metabolites undergo oxidative coupling to phenolic compounds to form nonhydrolyzable humic substance-like macromolecules. We found indications that monomeric educts are coupled by C-C- or either bonds. Hydrolyzable ester bonds or sorption of the parent compounds plays a minor role in residue formation. Moreover, experiments performed with 14CO2 revealed that residues may arise from CO2 in the soil in amounts typical for anthracene biodegradation. The extent of residue formation depends on the metabolic capacity of the soil microflora and the characteristics of the soil. The position of the 14C label is another important factor which controls mineralization and residue formation from metabolized compounds.  (+info)

Diverse oxygenations catalyzed by carbazole 1,9a-dioxygenase from Pseudomonas sp. Strain CA10. (3/915)

Carbazole 1,9a-dioxygenase (CARDO) from Pseudomonas sp. strain CA10 is a multicomponent enzyme that catalyzes the angular dioxygenation of carbazole, dibenzofuran, and dibenzo-p-dioxin. It was revealed by gas chromatography-mass spectrometry and 1H and 13C nuclear magnetic resonance analyses that xanthene and phenoxathiin were converted to 2,2',3-trihydroxydiphenylmethane and 2,2',3-trihydroxydiphenyl sulfide, respectively. Thus, for xanthene and phenoxathiin, angular dioxygenation by CARDO occurred at the angular position adjacent to the oxygen atom to yield hetero ring-cleaved compounds. In addition to the angular dioxygenation, CARDO catalyzed the cis dihydroxylation of polycyclic aromatic hydrocarbons and biphenyl. Naphthalene and biphenyl were converted by CARDO to cis-1, 2-dihydroxy-1,2-dihydronaphthalene and cis-2,3-dihydroxy-2, 3-dihydrobiphenyl, respectively. On the other hand, CARDO also catalyzed the monooxygenation of sulfur heteroatoms in dibenzothiophene and of the benzylic methylenic group in fluorene to yield dibenzothiophene-5-oxide and 9-hydroxyfluorene, respectively. These results indicate that CARDO has a broad substrate range and can catalyze diverse oxygenation: angular dioxygenation, cis dihydroxylation, and monooxygenation. The diverse oxygenation catalyzed by CARDO for several aromatic compounds might reflect the differences in the binding of the substrates to the reaction center of CARDO.  (+info)

Comparative tumorigenicity of the cyclopenta-fused polycyclic aromatic hydrocarbons aceanthrylene, dihydroaceanthrylene and acephenanthrylene in preweanling CD-1 and BLU:Ha mouse bioassays. (4/915)

Cyclopenta-fused polycyclic aromatic hydrocarbons are ubiquitous environmental pollutants and potential human health biohazards. In this study, the tumorigenicity of three single cyclopenta-fused polycyclic aromatic hydrocarbons, aceanthrylene, dihydroaceanthrylene and acephenanthrylene, was examined in preweanling CD-1 and BLU:Ha mouse bioassays at total doses of 175, 437.5 and 875 micrograms/mouse. No death or significant toxicity was observed with the treatment protocol in the tested animals. In CD-1 mice, a significant increase in lung tumor incidence (18-26%, P < 0. 025-0.01) for these three compounds was recorded in animals treated with 875 micrograms as compared with the control animals (3%). Significant numbers of liver tumors (25-41%, P < 0.01-0.001) were induced in all aceanthrylene treatment groups and in animals treated with 875 micrograms acephenanthrylene (35%) at the termination at 9 months. Most liver tumors were induced in male animals. The ED50 values were estimated as 8.5, 10.6 and 12.8 micromol and the TM1.0 were 15.1, 20.4 and 23.1 micromol for aceanthrylene, acephenanthrylene and dihydroaceanthrylene, respectively. In BLU:Ha mice, there was a significant dose-dependent increase in lung tumor incidence, from 4% for the control group to 33% (P < 0.001) for the animals treated with 875 micrograms aceanthrylene and to 24% (P < 0.02) for the animals treated with 437.5 micrograms acephenanthrylene. The ED50 values were 6.0 and 4.4 micromol and the TM1.0 were 9.8 and 6.8 micromol for aceanthrylene and acephenanthrylene, respectively. No significant difference in lung tumor incidence between male and female mice was found. Based on these data and comparisons of tumorigenic potency with other polycyclic aromatic hydrocarbons previously tested in these newborn mouse bioassays, aceanthrylene and acephenanthrylene were classified as weak tumorigens.  (+info)

Myeloma cells selected for resistance to CD95-mediated apoptosis are not cross-resistant to cytotoxic drugs: evidence for independent mechanisms of caspase activation. (5/915)

We have previously shown that selection for resistance to the anthracenes, doxorubicin or mitoxantrone, results in coselection for resistance to CD95-mediated apoptosis (Landowski et al: Blood 89:1854, 1997). In the present study, we were interested in determining if the converse is also true; that is, does selection for CD95 resistance coselect for resistance to chemotherapeutic drugs. To address this question, we used two isogenic models of CD95-resistant versus CD95-sensitive cell lines: 8226/S myeloma cells selected for resistance to CD95-mediated apoptosis; and K562 cells expressing ectopic CD95. Repeated exposure of the CD95-sensitive human myeloma cell line, 8226/S, to agonistic anti-CD95 antibody resulted in a cell line devoid of CD95 receptor surface expression and completely resistant to CD95-mediated apoptosis. Multiple clonal populations derived from the CD95-resistant cell line showed no difference in sensitivity to doxorubicin, mitoxantrone, Ara-C, or etoposide, demonstrating that cross-resistance between Fas-mediated apoptosis and drug-induced apoptosis occurs only when cytotoxic drugs are used as the selecting agent. Using the inverse approach, we transfected the CD95-negative cell line, K562, with a CD95 expression vector. Clones expressing variable levels of cell-surface CD95 were isolated by limiting dilution, and analyzed for sensitivity to CD95-mediated apoptosis and response to chemotherapeutic drugs. We show that CD95 surface expression confers sensitivity to CD95-mediated apoptosis; however, it does not alter response to chemotherapeutic drugs. Similarly, doxorubicin-induced activation of caspases 3 and 8 was identical in the CD95-sensitive and CD95-resistant cell lines in both isogenic cell systems. In addition, prior treatment with the CD95 receptor-blocking antibody, ZB4, inhibited CD95-activated apoptosis in 8226/S cells, but had no effect on doxorubicin cytotoxicity. These results show that CD95 and chemotherapeutic drugs use common apoptotic effectors, but the point of convergence in these two pathways is downstream of CD95 receptor/ligand interaction.  (+info)

Development of a new bioluminescent mutagenicity assay based on the Ames test. (6/915)

A newly developed rapid mutagenicity assay based on the adenosine triphosphate (ATP)-bioluminescence technique and the Ames test is described. Salmonella typhimurium strains TA98 and TA100 were exposed in an appropriate liquid medium to the direct mutagens 4-nitroquinoline-N-oxide and methyl methanesulphonate, respectively, and to the indirect mutagen 2-aminoanthracene. Both auxotrophic and prototrophic growth were monitored throughout the incubation period as variations in the intracellular ATP levels by means of the luciferin-luciferase assay. After 9-12 h of incubation a dose-response increase in the levels of ATP was readily detected. In order to demonstrate that this increase was due to the growth of revertant bacteria, aliquots from each culture were plated on minimal agar plates. A very good correlation between the changes in ATP levels and the appearance of revertant colonies on the plates was found. Given the rapidity of this method as compared with conventional mutagenicity assays, it has potential for industrial and environmental applications. Other potential applications are also discussed.  (+info)

Polycyclic aromatic hydrocarbon metabolism by white rot fungi and oxidation by Coriolopsis gallica UAMH 8260 laccase. (7/915)

We studied the metabolism of polycyclic aromatic hydrocarbons (PAHs) by using white rot fungi previously identified as organisms that metabolize polychlorinated biphenyls. Bran flakes medium, which has been shown to support production of high levels of laccase and manganese peroxidase, was used as the growth medium. Ten fungi grown for 5 days in this medium in the presence of anthracene, pyrene, or phenanthrene, each at a concentration of 5 microg/ml could metabolize these PAHs. We studied the oxidation of 10 PAHs by using laccase purified from Coriolopsis gallica. The reaction mixtures contained 20 microM PAH, 15% acetonitrile in 60 mM phosphate buffer (pH 6), 1 mM 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS), and 5 U of laccase. Laccase exhibited 91% of its maximum activity in the absence of acetonitrile. The following seven PAHs were oxidized by laccase: benzo[a]pyrene, 9-methylanthracene, 2-methylanthracene, anthracene, biphenylene, acenaphthene, and phenanthrene. There was no clear relationship between the ionization potential of the substrate and the first-order rate constant (k) for substrate loss in vitro in the presence of ABTS. The effects of mediating substrates were examined further by using anthracene as the substrate. Hydroxybenzotriazole (HBT) (1 mM) supported approximately one-half the anthracene oxidation rate (k = 2.4 h(-1)) that ABTS (1 mM) supported (k = 5.2 h(-1)), but 1 mM HBT plus 1 mM ABTS increased the oxidation rate ninefold compared with the oxidation rate in the presence of ABTS, to 45 h(-1). Laccase purified from Pleurotus ostreatus had an activity similar to that of C. gallica laccase with HBT alone, with ABTS alone, and with 1 mM HBT plus 1 mM ABTS. Mass spectra of products obtained from oxidation of anthracene and acenaphthene revealed that the dione derivatives of these compounds were present.  (+info)

Nepalolide A inhibits the expression of inducible nitric oxide synthase by modulating the degradation of IkappaB-alpha and IkappaB-beta in C6 glioma cells and rat primary astrocytes. (8/915)

1 The effects of nepalolide A on the expression of inducible nitric oxide synthase (iNOS) caused by incubation with lipopolysaccharide/interferon-gamma (LPS/IFN-gamma) or tumour necrosis factor-alpha/interleukin-1beta/IFN-gamma (TNF-alpha/IL-1beta/IFN-gamma, mixed cytokines) in C6 glioma cells and primary astrocytes of rat were investigated. The mechanisms by which nepalolide A confers its effect on iNOS expression were also elucidated. 2 Treatment with LPS/IFN-gamma and mixed cytokines for 24 h elicited the induction of iNOS activity as determined by nitrite accumulation in the culture medium and assay of enzyme activity. Nepalolide A at 10 microM abrogated the LPS/IFN-gamma- and mixed cytokines-mediated induction of iNOS by more than 90% in C6 glioma cells, and by 80% for mixed cytokines-induced induction of iNOS in primary astrocytes. The effect of nepalolide A (2-10 microM) was concentration-dependent. 3 The inhibition of iNOS induction by nepalolide A was attributed to decreases in the content of iNOS protein and the level of iNOS mRNA, as measured by immunoblotting and reverse transcriptase-polymerase chain reaction. 4 Electrophoretic mobility shift assay was used to evaluate the effect of nepalolide A on the activation of nuclear factor-kappaB (NF-kappaB). Results showed that nepalolide A diminished the LPS/IFN-gamma-mediated association of NF-kappaB with consensus oligonucleotide in a concentration-dependent manner. The activation of NF-kappaB by mixed cytokines was modulated both in the extent of activation and in its time-course by nepalolide A. 5 The ability of nepalolide A to inhibit NF-kappaB activation was further confirmed by studies on the degradation of the inhibitor of NF-kappaB, IkappaB, as measured by immunoblotting. 6 The present study demonstrates that the attenuation of NF-kappaB activation by nepalolide A was mediated by blockade of the degradation of IkappaB, leading to suppression of the expression of iNOS.  (+info)

9,10-Dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylic acid, CAS Number: 13739-02-1
9,10-Dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylic acid - chemical information, properties, structures, articles, patents and more chemical data.
http://www.chemindustry.com/chemicals/0548729.html
Anthracene | Open Access articles | Open Access journals | Conference Proceedings | Editors | Authors | Reviewers | scientific...
The dimer, called dianthracene (or sometimes paranthracene), is connected by a pair of new carbon-carbon bonds, the result of the [4+4] cycloaddition. It reverts to anthracene thermally or with UV irradiation below 300 nm. The reversible dimerization and the photochromic properties of anthracenes are the basis of potential applications.[11] Substituted anthracene derivatives behave similarly. The reaction is affected by the presence of oxygen. In general, reduction of anthracene yields 9,10-dihydroanthracene (destroying the aromaticity of the center ring) rather than 1,4-dihydroanthracene (which would destroy the aromaticity of one of the terminal rings). This preference for reduction at the 9 and 10 positions is explained by the fact that aromatic stabilization energy is directly correlated with the number of conjugated pi bonds in an aromatic system. Since 9,10-dihydroanthracene in essence preserves two benzene rings (a total of 6 conjugated pi bonds), whereas the 1,4-isomer preserves only ...
http://research.omicsgroup.org/index.php/Anthracene
Molecules | Free Full-Text | Organocatalytic Oxidative Dehydrogenation of Dihydroarenes by Dioxygen Using 2,3-Dichloro-5,6...Molecules | Free Full-Text | Organocatalytic Oxidative Dehydrogenation of Dihydroarenes by Dioxygen Using 2,3-Dichloro-5,6...
The oxidative dehydrogenation of dihydroarenes catalyzed by 2,3-dichloro-5,6-dicyano-benzoquinone(DDQ) and NaNO2 with dioxygen is reported. The combination of DDQ and NaNO2 showed high efficiency and high selectivity, compared with other benzoquinones and anthraquinones, e.g., |99% conversion of 9,10-dihydroanthracene with 99% selectivity for anthracene can be obtained at 120 °C under 1.3 MPa O2 for 8 h. Excellent results were achieved in the oxidative dehydrogenation of variety of dihydroarenes.
http://www.mdpi.com/1420-3049/13/12/3236
PQR | Anthra[2,1,9-def:6,5,10-def]diisoquinoline-1,3,8,10(2h,9h)-tetrone, 2,9-dimethylPQR | Anthra[2,1,9-def:6,5,10-def]diisoquinoline-1,3,8,10(2h,9h)-tetrone, 2,9-dimethyl
You are viewing an interactive 3D depiction of the molecule anthra[2,1,9-def:6,5,10-def]diisoquinoline-1,3,8,10(2h,9h)-tetrone, 2,9-dimethyl- (C26H34N2O4) from the PQR.
http://pqr.pitt.edu/mol/PJQYNUFEEZFYIS-UHFFFAOYSA-N
EPO - T 1419/12 (ORGANIC ELECTROLUMINESCENCE DEVICE/ IDEMITSU KOSAN) of 19.3.2015EPO - T 1419/12 (ORGANIC ELECTROLUMINESCENCE DEVICE/ IDEMITSU KOSAN) of 19.3.2015
Summary of Facts and Submissions. I. The Appellant (Opponent) lodged an appeal against the interlocutory decision of the Opposition Division which found that the European patent No. 1 553 154 amended according to the then pending auxiliary request 1 met the requirements of the EPC.. II. Notice of opposition had been filed by the Appellant requesting revocation of the patent in suit in its entirety on the grounds of lack of novelty and inventive step (Article 100(a) EPC) and insufficient disclosure (Article 100(b) EPC). Inter alia the following documents were submitted in the opposition proceedings:. (1) EP-A-0 857 007,. (2) EP-A-1 009 044 and. (3) EP-A-1 167 488.. III. According to the Opposition Division, the specification of the patent-in-suit contained sufficient information to enable the skilled person to carry out the invention across the whole breadth of the claims. Contrary to the assertion of the opponent, the wording asymmetric anthracene derivative represented by the formula (2) gave ...
http://www.epo.org/law-practice/case-law-appeals/recent/t121419eu1.html
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Controlled Labs - Blue GrowtH - Write up & FAQ *** - AnabolicMinds.comControlled Labs - Blue GrowtH - Write up & FAQ *** - AnabolicMinds.com
CONTROLLED LABS - Blue GrowtH™ FAQ & Write up What is Blue GrowtH™ ? Key Attributes: - Serum GH level enhancement - Deeper, more
http://anabolicminds.com/forum/company-promotions/159307-controlled-labs-blue.html
Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution...
TY - JOUR. T1 - Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution-Processed Organic Light-Emitting Diodes. AU - Hayashi, Hironobu. AU - Kato, Yuki. AU - Matsumoto, Akinobu. AU - Shikita, So. AU - Aizawa, Naoya. AU - Suzuki, Mitsuharu. AU - Aratani, Naoki. AU - Yasuda, Takuma. AU - Yamada, Hiroko. N1 - Funding Information: This work was partly supported by CREST JST (No. JPMJCR15F1) and Grants‐in‐Aid for Scientific Research (Nos. JP26105004, JP26288038, JP17H03042, JP19K22112, JP19H04584, JP16H02286, and JP18K14190). We thank Ms. Y. Nishikawa, NAIST for the mass spectroscopy measurements. Funding Information: This work was partly supported by CREST JST (No. JPMJCR15F1) and Grants-in-Aid for Scientific Research (Nos. JP26105004, JP26288038, JP17H03042, JP19K22112, JP19H04584, JP16H02286, and JP18K14190). We thank Ms. Y. Nishikawa, NAIST for the mass spectroscopy measurements. Publisher Copyright: © 2019 Wiley-VCH Verlag ...
https://kyushu-u.pure.elsevier.com/en/publications/synthesis-of-anthracene-derivatives-with-azaacene-containing-ipty
Influence of amino acid sequence on the interaction of short peptides containing 3-[2-(9-anthryl)benzoxazol-5-yl]-alanine with...
The influence of peptide sequence and Leu chirality in linear and cyclic peptides containing 3-[2-(9-anthryl)benzoxazol-5-yl]alanine on interaction with β-cyclodextrin were studied using fluorescence and NMR spectroscopy. The analysis of enthalpy-entropy compensation effect (α=1.05±0.02 and TΔS00=15.1±0.5 kJ mol−1) indicates that the entropic contribution connected with the solvent reorganization is the major factor governing the peptides-β-cyclodextrin complexation. Moreover, spatial orientation of guest-host molecule depends more than association constant on Leu residue configuration. However, the cyclization of the peptide chain substantially decrease the association constant with β-CD. An analysis of 2D NMR spectra reveals that inclusion complex is formed by penetration of cyclodextrin cavity from wider and narrow rims by anthryl group in the case of Box(Ant)-SPKL or anthryl and Leu residues for Box(Ant)-SPK(D)L analogue ...
http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.-psjd-doi-10_2478_s11532-011-0103-x
A Link between Benzyl Isothiocyanate-Induced Cell Cycle Arrest and Apoptosis: Involvement of Mitogen-Activated Protein Kinases...A Link between Benzyl Isothiocyanate-Induced Cell Cycle Arrest and Apoptosis: Involvement of Mitogen-Activated Protein Kinases...
In the present study, we clarified the molecular mechanism underlying the relationship between benzyl isothiocyanate (BITC)-induced cell cycle arrest and apoptosis and the involvement of mitogen-activated protein kinases (MAPKs). The exposure of Jurkat human T-cell leukemia cells to BITC resulted in the inhibition of the G2-M progression that coincided with the apoptosis induction. The experiment using the phase-specific synchronized cells demonstrated that the G2-M phase-arrested cells are more sensitive to undergoing apoptotic stimulation by BITC than the cells in other phases. We also confirmed that BITC activated c-Jun N-terminal kinase (JNK) and p38 MAPK, but not extracellular signal-regulated kinase, at the concentration required for apoptosis induction. An experiment using a JNK-specific inhibitor SP600125 or a p38 MAPK inhibitor SB202190 indicated that BITC-induced apoptosis might be regulated by the activation of these two kinases. Conversely, BITC is likely to confine the Jurkat cells ...
https://cancerres.aacrjournals.org/content/64/6/2134.abstract
Anthracene - New World EncyclopediaAnthracene - New World Encyclopedia
The dimer is connected by two covalent bonds resulting from the [4+4] cycloaddition. The dimer reverts to anthracene thermally or with UV irradiation below 300 nm. The reversible bonding and photochromic properties of anthracenes are the basis of many potential applications using poly and monosubstituted anthracene derivatives. The reaction is sensitive to oxygen.. In most other reactions of anthracene, the central ring is also targeted, as it is the most highly reactive. Electrophilic substitution occurs at the 9 and 10 positions of the center ring, and oxidation of anthracene occurs readily, giving anthraquinone, C14H8O2 (below).. ...
http://www.newworldencyclopedia.org/entry/Anthracene
CCDC 1526053: Experimental Crystal Structure Determination : 5,5-difluoro-1,3,7,9-tetramethyl-10-(10-methyl-9-anthryl)-5H-6,5...
Filatov, M. A. (Creator), Karuthedath, S. (Creator), Polestshuk, P. M. (Creator), Savoie, H. (Creator), Flanagan, K. J. (Creator), Sy, C. (Creator), Sitte, E. (Creator), Telitchko, M. (Creator), Laquai, F. (Creator), Boyle, R. W. (Creator), Senge, M. O. (Creator), Filatov, M. A. (Creator), Polestshuk, P. M. (Creator), Savoie, H. (Creator), Flanagan, K. J. (Creator), Sy, C. (Creator), Sitte, E. (Creator), Telitchko, M. (Creator), Boyle, R. W. (Creator), Senge, M. O. (Creator) (Aug 9 2017). CCDC 1526053: Experimental Crystal Structure Determination : 5,5-difluoro-1,3,7,9-tetramethyl-10-(10-methyl-9-anthryl)-5H-6,5-dipyrrolo[1,2-c:2,1-f][1,3,2]diazaborinine. Cambridge Crystallographic Data Centre. 10.5517/ccdc.csd.cc1n6zjc ...
https://research.kaust.edu.sa/en/datasets/ccdc-1526053-experimental-crystal-structure-determination-55-difl-2
Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis | RTIAlvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis | RTI
Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E?N (1?10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, and preliminary structure?activity
https://www.rti.org/publication/alvaradoins-e-n-antitumor-and-cytotoxic-anthracenone-c-glycosides-leaves-alvaradoa
Difference between revisions of Cfrench:anthrone - OpenWetWareDifference between revisions of Cfrench:anthrone - OpenWetWare
Procedure 1.Add 2mL samples or standards [0(pure water), 5, 10, 25, 50, 80µg/2mL] solution into all prepared test tubes. 2.(In chemical hood) Use glass pipette and gently add 0.5mL 2% anthrone solution into each test tube. There will be two layers of this solution. The upper layer is anthrone and the lower layer is the sample/standard. Try not to disturb solution, because ethyl acetate is easy to vaporize. 3.(In chemical hood) Use glass pipette to add 5mL concentrated sulfuric acid into the tube gently. Put the tip of pipette into the bottom of lower layer. Concentrated sulfuric acid will vaporize ethyl acetate immediately if you drop this sulfuric acid on it. [SAFETY NOTES: sulfuric acid is highly hazardous (corrosive, irritant). Be sure to wear gloves and prevent direct contact.] (The test tube will be very hot after sulfuric acid is added. Hold the higher part of test tube to prevent burning your fingers) 4.(In chemical hood) Swirl gently and youll see the vaporization of ethyl acetate. ...
https://openwetware.org/wiki/?title=Cfrench:anthrone&diff=504176&oldid=234512
Kinetic Isotope Effect Probes the Reactive Spin State, As Well As the Geometric Feature and Constitution of the Transition...Kinetic Isotope Effect Probes the Reactive Spin State, As Well As the Geometric Feature and Constitution of the Transition...
What do experimentally measured kinetic isotope effects (KIEs) tell us about H-abstraction reactions with multispin-state reactivity options? Using DFT calculations with tunneling corrections for experimentally studied H-abstraction reactions of porphyrin-Compound II species (Chem.-Eur. J. 2014, 20, 14437; Angew. Chem., Int. Ed. 2008, 47, 7321) with cyclohexane, dihydroanthracene (DHA), and xanthene (Xan), we show here that KIE is a selective probe that identifies the experimentally reactive spi
https://www.researcher-app.com/paper/26277
ANTHRONE - Manufacturer, Supplier & ExporterANTHRONE - Manufacturer, Supplier & Exporter
ALPHA CHEMIKA is an ISO 9001:2000 certified manufacturer, supplier & exporter of ANTHRONE including all laboratory Chemicals, and offered to our clients at the best industry prices, Inquire us for more products details.
http://www.alphachemikaindia.com/anthrone-2747507.html
Anthracene
Name: CA Name: Anthracene Molecular Structure: Anthracene,CAS 120-12-7,178.23,C14H10 Anthracene,CAS 120-12-7,178.23,C14H10 Molecular Formula:C14H10 Molecular Weight: 178.23 CAS Registry Number: 120-12-7
http://www.dyestuffintermediates.com/dye-intermediates/anthracene.html
Anthra[1,2,3,4-ghi]peryleneAnthra[1,2,3,4-ghi]perylene
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
http://webbook.nist.gov/cgi/inchi/InChI%3D1S/C30H16/c1-2-6-20-16-26-24-14-12-18-8-4-10-22-21-9-3-7-17-11-13-23
2,9-bis[4-(phenylazo)phenyl]anthra[2,1,9-def:6,... - Registration Dossier - ECHA2,9-bis[4-(phenylazo)phenyl]anthra[2,1,9-def:6,... - Registration Dossier - ECHA
In October 2011 the EU commission published a recommendation (2011/696/EU) on the definition of nanomaterials. Standardised and certified methodologies (which are essential for accurate material characterisation, comparison and categorisation) to accompany this recommendation are now in development. From the results of analysis by the non-standardised methods currently available, it is conceivable that the substance subject to registration could be considered as falling within the boundaries of the nanomaterial definition. ...
https://echa.europa.eu/bg/registration-dossier/-/registered-dossier/11769/4/2
AMDA Guidance on COVID-19 | Article | IRC Physiatry GroupAMDA Guidance on COVID-19 | Article | IRC Physiatry Group
Guidance from The Society For Post-Acute And Long-Term Care Medicine (AMDA), who are closely monitoring the COVID-19 (novel coronavirus) outbreak.
http://irehabconsultants.com/amda-guidance-on-covid-19-in-paltc-settings/
Solvent Red 149Solvent Red 149
Name:C.I.Solvent Red 149,C.I.674700 Molecular Structure: Pyrimidine Anthrone C.I.Solvent Red 149,C.I.674700,CAS 71902-18-6,358.43,C23H22N2O2,Solvent Red G,Transparent Red G,Fluorescent Red HFG,Oil Red 149 C.I.Solvent Red 149,C.I.674700,CAS 71902-18-6,358.43,C23H22N2O2,Solvent Red G,Transparent Red G,Fluorescent Red HFG,Oil Red 149 Molecular Formula:C23H22N2O2 Molecular Weight: 358.43 CAS Registry Number:71902-18-6
http://www.worlddyevariety.com/solvent-dyes/solvent-red-149.html
Manufacturing Apparatus and Manufacturing Method of Lighting Device - Patent applicationManufacturing Apparatus and Manufacturing Method of Lighting Device - Patent application
0261]Blue-green to green light emission can be obtained, for example, by using a coumarin dye such as coumarin 30 or coumarin 6, bis[2-(2,4-difluorophenyl)pyridinato]picolinatokidium (abbreviation: FIrpic), bis(2-phenylpyridinato)acetylacetonatoiridium (abbreviation: Ir(ppy)2(acac)), or the like as a guest material and dispersing the guest material in a suitable host material. Further, blue-green to green light emission can be obtained by dispersing perylene or TBP, which are mentioned above, in a suitable host material at a high concentration of 5 wt % or more. Further alternatively, blue-green to green light emission can be obtained from a metal complex such as BAlq, Zn(BTZ)2, or bis(2-methyl-8-quinolinolato)chlorogallium (Ga(mq)2Cl). Further, a polymer such as poly(p-phenylenevinylene) may be used. Further, an anthracene derivative is preferable as a guest material of a blue-green to green light-emitting layer, as high light-emitting efficiency can be obtained when an anthracene derivative is ...
http://www.patentsencyclopedia.com/app/20100236691
3,5-disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors3,5-disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors
The structure-based design and synthesis of a novel series of c-Jun N-terminal kinase (JNK) inhibitors with selectivity against p38 is reported. The unique structure of 3,5-disubstituted quinolines (2) was developed from the previously reported 4-(2,7-phenanthrolin-9-yl)phenol (1). The X-ray crystal structure of 16a in JNK3 reveals an unexpected binding mode for this new scaffold with protein ...
https://vivo.scripps.edu/display/endnote111659
ChemIDplus - 29311-94-2 - SYZOCKFTUCTLFQ-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,4-bis((3-chloro-2-hydroxypropyl)amino)- -...ChemIDplus - 29311-94-2 - SYZOCKFTUCTLFQ-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,4-bis((3-chloro-2-hydroxypropyl)amino)- -...
29311-94-2 - SYZOCKFTUCTLFQ-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,4-bis((3-chloro-2-hydroxypropyl)amino)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/29311-94-2
ChemIDplus - 55345-44-3 - QFYZUUMEXXFCKY-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,5-bis((4-phenoxyphenyl)amino)- - Similar...ChemIDplus - 55345-44-3 - QFYZUUMEXXFCKY-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,5-bis((4-phenoxyphenyl)amino)- - Similar...
55345-44-3 - QFYZUUMEXXFCKY-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,5-bis((4-phenoxyphenyl)amino)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
https://chem.nlm.nih.gov/chemidplus/rn/55345-44-3
2-(Pyrazol-5-yl)phenol 34810-67-8 MSDS, Safety Technical Specifications MSDS2-(Pyrazol-5-yl)phenol 34810-67-8 MSDS, Safety Technical Specifications MSDS
2-(Pyrazol-5-yl)phenol 34810-67-8 MSDS report, 2-(Pyrazol-5-yl)phenol MSDS safety technical specifications search, 2-(Pyrazol-5-yl)phenol safety information specifications ect.
http://www.molbase.com/en/msds_34810-67-8-moldata-47255.html
4-(pyrazol-1-ylmethyl)benzoic acid 160388-53-4 H-NMR | C-NMR Spectral Analysis NMR Spectrum4-(pyrazol-1-ylmethyl)benzoic acid 160388-53-4 H-NMR | C-NMR Spectral Analysis NMR Spectrum
4-(pyrazol-1-ylmethyl)benzoic acid 160388-53-4 NMR spectrum, 4-(pyrazol-1-ylmethyl)benzoic acid H-NMR spectral analysis, 4-(pyrazol-1-ylmethyl)benzoic acid C-NMR spectral analysis ect.
http://www.molbase.com/en/hnmr_160388-53-4-moldata-13581.html
2,9-bis(2-phenylethyl)anthra[2,1,9-def:6,5,10-d... - Registration Dossier - ECHA2,9-bis(2-phenylethyl)anthra[2,1,9-def:6,5,10-d... - Registration Dossier - ECHA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
https://echa.europa.eu/en/registration-dossier/-/registered-dossier/11512/5/4/2
9,10-Anthracenedione, 1,2,4-trihydroxy9,10-Anthracenedione, 1,2,4-trihydroxy
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
http://webbook.nist.gov/cgi/inchi/InChI%3D1S/C14H8O5/c15-8-5-9
Chemical synthesis of nucleoside analogs: Enumeration
Synthesis How to make a great presentation in powerpoint novel sugar or azasugar analog anthra[1,2- d ] imidazole-6,dione derivatives and interesting evaluation.
https://reath.me/enumeration/chemical-synthesis-of-nucleoside-analogs-15151.html
Other Peptide Receptors - Insights into the Mechanism of ATP-competitive JNK inhibitorsOther Peptide Receptors - Insights into the Mechanism of ATP-competitive JNK inhibitors
of just one 1,000 U/ml, and one protease inhibitor tablet/50ml (Roche Cat #04693132001). On the other hand, the goals of antibodies in the same mice […]. Continue reading ...
https://wcsmo6.org/category/other-peptide-receptors/
Frontiers | JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development | Cellular NeuroscienceFrontiers | JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development | Cellular Neuroscience
JNK signaling is known to play a role in regulating cell behaviors such as cell cycle progression, cell proliferation, and apoptosis, and recent studies have suggested important roles for JNK signaling in embryonic development. However, the precise function of JNK signaling in hair cell development remains poorly studied. In this study, we used the small molecule JNK inhibitor SP600125 to examine the effect of JNK signaling abrogation on the development of hair cells in the zebrafish lateral line neuromast. Our results showed that SP600125 reduced the numbers of both hair cells and supporting cells in neuromasts during larval development in a dose-dependent manner. Additionally, JNK inhibition strongly inhibited the proliferation of neuromast cells, which likely explains the decrease in the number of differentiated hair cells in inhibitor-treated larvae. Furthermore, western blot and in situ analysis showed that JNK inhibition induced cell cycle arrest through induction of p21 expression. We also showed
https://www.frontiersin.org/articles/10.3389/fncel.2016.00019/full
Synthesis of spirocyclopente-dione anthracene adduct, precursor of the by Gedsirin Eksinitkun, Stephen G. Pyne et al.Synthesis of spirocyclopente-dione anthracene adduct, precursor of the by Gedsirin Eksinitkun, Stephen G. Pyne et al.
A synthesis of the spirocyclopente-dione anthracene adduct, a precursor of the cyclopentenone prostaglandins has been reported. The synthesis involved a Diels-Alder reaction of anthracene and dimethyl fumarate to afford 3 followed by reduction, oxidation and esterification reactions to provide methyl ester anthracene adduct 8, which further converted to the the allylic alcohol (12). Then, Ring-Closing Metathesis (RCM) reaction afforded the cyclopentenol anthracene adduct, which after oxidation provided the spirocyclopente-dione anthracene adduct in good yields.
http://ro.uow.edu.au/smhpapers/1629/
Traumatic Injury in vitro Elicits JNK-mediated Human Astrocyte Retract by Claudia AugustineTraumatic Injury in vitro Elicits JNK-mediated Human Astrocyte Retract by Claudia Augustine
The pathophysiology of a traumatic brain injury (TBI) involves the dysfunction of the blood-brain barrier (BBB). The lumen of the BBB is lined with cerebrovascular endothelial cells (CVEC) that are ensheathed with perivascular astrocyte endfeet. We investigated the cellular response of human-astrocytes and human-CVEC following trauma in vitro. Astrocytes and CVEC were subjected to a concussive injury (CI; mechanical stretch), then assessed for markers of injury (monolayer retraction) and activation (mitogen-activated protein kinases (MAPK) phosphorylation). CI induces astrocyte monolayer retraction and activation, with predominant phosphorylation of JNK1/2 MAPK. Interfering with JNK1/2 activation (selective JNK inhibitors) reduces trauma-induced astrocyte retraction. On the contrary, CI does not induce CVEC retraction, however up-regulates CVEC pro-adhesive phenotype resulting in increased polymorphonuclear leukocyte (PMN) adhesion. These findings indicate that CI elicits differential BBB cell responses
https://ir.lib.uwo.ca/etd/1411/
Maprotiline (Ludiomil) uses and side effectsMaprotiline (Ludiomil) uses and side effects
The drug is not recommended for use in children. The possibility of suicide in seriously depressed patients is inherent in their illness and may persist until significant remission occurs. Therefore, patients must be carefully supervised during all phases of treatment with maprotiline and prescriptions should be written for the smallest amount consistent with good management. Safe use of Maprotiline during pregnancy or lactation has not been established; therefore, its use in pregnancy, in nursing mothers or in women of childbearing potential requires that the benefits of treatment be weighed against the possible risks to mother and child. Patients should be kept under medical surveillance during treatment with maprotiline. The dosage of maprotiline should be individualized according to the requirements of each patient. Do not share this medicine with others for whom it was not prescribed. Do not use this medicine for other health conditions. After you stop taking this medicine, your body will ...
http://www.depression-guide.com/maprotiline.htm
OpenEmory | Search ResultsOpenEmory | Search Results
Angiotensin II (ANG II) has been implicated in the pathogenesis of diabetic micro- and macrovascular disease. In vascular smooth muscle cells (VSMCs), ANG II phosphorylates and degrades insulin receptor substrate-1 (IRS-1). While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH2-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. We investigated the role of JNK in ANG II-induced IRS-1 phosphorylation, degradation, Akt activation, glucose uptake, and hypertrophic signaling, focusing on three IRS-1 phosphorylation sites: Ser302, Ser307, and Ser632. Maximal IRS-1 phosphorylation on Ser632 occurred at 5 min, on Ser307 at 30 min, and on Ser302 at 60 min. The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). However, JNK inhibition had no effect on ANG II-mediated IRS-1 degradation, nor did it reverse the ...
https://open.library.emory.edu/publications/search/?subject=Biology%2C+Cell&subject=Biology%2C+Physiology&keywords=signal
OpenEmory | Search ResultsOpenEmory | Search Results
Angiotensin II (ANG II) has been implicated in the pathogenesis of diabetic micro- and macrovascular disease. In vascular smooth muscle cells (VSMCs), ANG II phosphorylates and degrades insulin receptor substrate-1 (IRS-1). While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH2-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. We investigated the role of JNK in ANG II-induced IRS-1 phosphorylation, degradation, Akt activation, glucose uptake, and hypertrophic signaling, focusing on three IRS-1 phosphorylation sites: Ser302, Ser307, and Ser632. Maximal IRS-1 phosphorylation on Ser632 occurred at 5 min, on Ser307 at 30 min, and on Ser302 at 60 min. The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). However, JNK inhibition had no effect on ANG II-mediated IRS-1 degradation, nor did it reverse the ...
https://open.library.emory.edu/publications/search/?subject=Biology%2C+Physiology&author=San+Martin+Almeyda%2C+Alejandra&journal=American%20Journal%20of%20Physiology%20-%20Cell%20Physiology
Chrysarobin | Definition of Chrysarobin at Dictionary.comChrysarobin | Definition of Chrysarobin at Dictionary.com
Chrysarobin definition, a mixture of compounds obtained from Goa powder, used in the treatment of psoriasis and other skin conditions. See more.
https://www.dictionary.com/browse/chrysarobin
Pseudolaric Acid C | Fungal Inhibitor | MedChemExpressPseudolaric Acid C | Fungal Inhibitor | MedChemExpress
Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix kaempferi Gorden, has antifungal activity. - Mechanism of Action & Protocol.
https://www.medchemexpress.com/pseudolaric-acid-c.html
Maprotiline | Harvard Catalyst Profiles | Harvard CatalystMaprotiline | Harvard Catalyst Profiles | Harvard Catalyst
This graph shows the total number of publications written about Maprotiline by people in Harvard Catalyst Profiles by year, and whether Maprotiline was a major or minor topic of these publication ...
https://connects.catalyst.harvard.edu/Profiles/display/Concept/Maprotiline
Plus itPlus it
TheK i values of Cibacron blue, chrysin, 7,8-dihydroxyflavone, phenindone, and dicoumarol to rY128D, rG150V, and hH161Q were significantly greater than those for the wild-type human enzymes, indicating that Tyr128, Gly150, and His161 are situated in the binding pockets of these inhibitors. On the other hand, Tyr155 and His194 are probably not in direct contact with the inhibitors, because the binding of inhibitors are not affected by Tyr155 to Phe and His194 to Asp mutations.. The X-ray structure of Cibacron blue bound to rat DT-diaphorase has been published (Li et al., 1995) and was used to help interpret the results of our inhibition studies. The binding of Cibacron blue is significantly reduced by the Tyr128 to Asp mutation and the Gly150 to Val mutation. The K i values of Cibacron blue for rY128D and rG150V are 110 and 23 times that for the wild-type rat DT-diaphorase, respectively. The X-ray structural analysis revealed that the inhibitors trizaine ring is sandwiched between these two ...
http://molpharm.aspetjournals.org/content/56/2/272
DYEING COMPOSITION FREE OF CHEMICAL OXIDIZING AGENT, COMPRISING AN OXIDATION DYE, AN ALKYL SULFATE, AN ALKYLPOLYGLYCOSIDE,...DYEING COMPOSITION FREE OF CHEMICAL OXIDIZING AGENT, COMPRISING AN OXIDATION DYE, AN ALKYL SULFATE, AN ALKYLPOLYGLYCOSIDE,...
0037] Mention may also be made, as pyrazole derivatives, of diamino-N,N-dihydropyrazolopyrazolones and in particular those described in application FR-A-2 886 136, such as the following compounds and the addition salts thereof: 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-ethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-isopropylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-(pyrrolidin-1-yl)-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-on- e, 4,5-diamino-1,2-dimethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-diethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-di(2-hydroxyethyl)-1,2-dihydropyrazol-3-one, 2-amino-3-(2-hydroxyethyl)amino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-- 1-one, 2-amino-3-dimethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-- one, 2,3-diamino-5,6,7,8-tetrahydro-1H,6H-pyridazino[1,2-a]pyrazol-1-one, 4-amino-1,2-diethyl-5-(pyrrolidin-1-yl)-1,2-dihydropyrazol-3-one, ...
http://www.patentsencyclopedia.com/app/20150335564
SunPower (NASDAQ:SPWR) in Imported Declaration with Idera Pharmaceuticals (NASDAQ:IDRA), Amedica (NASDAQ:AMDA), Jacobs...SunPower (NASDAQ:SPWR) in Imported Declaration with Idera Pharmaceuticals (NASDAQ:IDRA), Amedica (NASDAQ:AMDA), Jacobs...
SunPower Corporation (NASDAQ:SPWR) (Full FREE Analysis of SPWR And Be Sure To Notice The Intermediate Period) declared its change time of third-quarter 2013 results conference call to 5:30 a.m. PT on Oct. 29, 2014. Due to conflicts in executives schedules, SunPower will now hold its third-quarter financial results conference call on Wednesday, Oct. 29 at […]
https://thecinemapost.com/sunpower-nasdaqspwr-in-imported-declaration-with-idera-pharmaceuticals-nasdaqidra-amedica-nasdaqamda-jacobs-engineering-group-nysejec/72477/
Solvent Red 114Solvent Red 114
Name:C.I.Solvent Red 114,C.I.68415 Molecular Structure: Pyrimidine Anthrone C.I.Solvent Red 114,C.I.68415,CAS 12226-90-3,511.36,C28H16Cl2N4O2,Fluorescent Red Orange 62365 C.I.Solvent Red 114,C.I.68415,CAS 12226-90-3,511.36,C28H16Cl2N4O2,Fluorescent Red Orange 62365 Molecular Formula:C28H16Cl2N4O2 Molecular Weight: 511.36 CAS Registry Number:12226-90-3
http://www.worlddyevariety.com/solvent-dyes/solvent-red-114.html
9-[Ethoxy-(8-quinolyl-amino)-methyl]-anthracene: Ingenta Connect9-[Ethoxy-(8-quinolyl-amino)-methyl]-anthracene: Ingenta Connect
The title compound, C26H22N2O, was readily synthesized from the reaction between 8-amino-quinoline and 9-anthr-aldehyde in EtOH solution. There is an intramolecular N-H…N hydrogen bond and weak C-H…N/O interactions. The mol-ecule self-assembles into a zigzag chain along the c axis through - interactions ...
https://www.ingentaconnect.com/content/bsc/aye/2004/00000060/00000012/art00171
氙 - 维基百科，自由的百科全书氙 - 维基百科，自由的百科全书
自然形成的氙共由7種穩定同位素組成，在各元素中排第二位。第一位是錫，其穩定同位素共有10個。穩定同位素數量高於7個的元素只有錫。[69]同位素134Xe根據預測能夠進行雙重β衰變，但這未經實驗證明，因此该同位素仍被認為是穩定的。[70]除這些穩定同位素之外，氙還有40多種不穩定同位素。其中壽命最長的為124Xe，它會進行双电子俘获衰變，半衰期為1.8×1022年。[6] 129I在β衰變後，會產生129Xe同位素。該反應的半衰期為1600萬年。另外131mXe、133Xe、133mXe和135Xe都是235U和239Pu的核裂變產物，[68]因此被用作探測核爆炸的發生。[71] ...
https://zh.wikipedia.org/wiki/%E6%B0%99
Loughborough University Institutional Repository: Electron transfer reactions in ternary systems on silica gel surfaces:...Loughborough University Institutional Repository: Electron transfer reactions in ternary systems on silica gel surfaces:...
Electron transfer reactions have been studied between 9-anthracenecarboxylic acid co-adsorbed with perylene on silica gel surfaces employing azulene as a molecular shuttle in order to facilitate hole transfer. In this paper we present for the first time a ternary system that unambiguously demonstrates an appreciable mobility of radical cations on the silica gel surface. Rates of hole transfer from the 9-anthracenecarboxylic acid radical cation to perylene via azulene have been studied using diffuse reflectance laser flash photolysis spectroscopy. Azulene has been shown to enhance the rate of electron transfer in the ternary system, proving significant mobility of the azulene and its radical cation species on silica gel surfaces. The data shows that the azulene radical cation can diffuse at an appreciable rate on the silica gel surface ...
https://dspace.lboro.ac.uk/dspace-jspui/handle/2134/16134
Polymers | Free Full-Text | Microspheres Containing Cibacron Blue F3G-A and Incorporated Iron Oxide Nanoparticles as Biomarker...Polymers | Free Full-Text | Microspheres Containing Cibacron Blue F3G-A and Incorporated Iron Oxide Nanoparticles as Biomarker...
In this work, magnetic functionality was introduced to cross-linked acrylamide-based particles via the in situ coprecipitation of iron oxide nanoparticles within the hydrogel particle interior. Cibacron Blue F3G-A was then incorporated onto the magnetic hydrogel scaffold to facilitate the harvest of targeted protein species. The dye-loaded magnetic particles were physically characterized, and their protein sequestration performance was investigated. The results of these studies indicated that dye-loaded magnetic particles sequestered a greater amount of lower molecular weight proteins from the test solution than was achieved using reference particles, dye-loaded cross-linked N-isopropylacrylamide-based core-shell particles. This difference in protein harvesting ability may reflect the higher degree of dye-loading in the magnetic particles relative to the dye-loaded core-shell particles.
http://www.mdpi.com/2073-4360/3/3/1181/notes
Dibenz(a,h)Anthracene (IARC Summary & Evaluation, Volume 3, 1973)Dibenz(a,h)Anthracene (IARC Summary & Evaluation, Volume 3, 1973)
Dibenz(a,h)anthracene has produced tumours by different routes of administration in mice, rats, guinea pigs, frogs, pigeons and chickens. It has both local and systemic carcinogenic effects.. On oral administration, it produced tumours of the forestomach in the mouse; intratracheal administration to rats produced lung tumours. In repeated skin painting experiments in mice, dibenz(a,h)anthracene and benzo(a)pyrene appeared to be equally effective. In a dose-response study on s.c. carcinogenicity with dibenz(a,h)anthracene, benzo(a)pyrene and 3-methylcholanthrene, dibenz(a,h)anthracene was shown to be effective at a lower dose than that effective for benzo(a)pyrene or for 3-methylcholanthrene; its latent period, however, was longer. Dibenz(a,h)anthracene induced local sarcomas and increased the incidence of lung adenomas following a single s.c. injection in newborn mice at dose levels which were ineffective with 3-methylcholanthrene. It has not been adequately tested in other species. ...
http://inchem.org/documents/iarc/vol03/dibenz
Dibenz[a,h]anthracene (IARC Summary & Evaluation, Volume 32, 1983)Dibenz[a,h]anthracene (IARC Summary & Evaluation, Volume 32, 1983)
Dibenz[a,h]anthracene has been shown to be carcinogenic to experimental animals.. Dibenz[a,h]anthracene is embryotoxic to rats when given at high doses. The available data on teratogenicity were inadequate for evaluation. Dibenz[a,h]anthracene was positive in differential survival assays using DNA-repair-proficient/-deficient strains of bacteria and was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. In cultured mammalian cells, dibenz[a,h]anthracene was mutagenic and induced unscheduled DNA synthesis in the presence of an exogenous metabolic system. It was positive in assays for morphological transformation. In the one available study, it induced sister chromatid exchange but not chromosomal aberrations in vivo.. There is sufficient evidence that dibenz[a,h]anthracene is active in short-term tests. ...
http://inchem.org/documents/iarc/vol32/dibenz%5Ba,h%5Danthracene.html
Efectos tóxicos del alquilbencensulfonato lineal, antraceno y su mezcla sobre el crecimiento de un consorcio microbiano aislado...Efectos tóxicos del alquilbencensulfonato lineal, antraceno y su mezcla sobre el crecimiento de un consorcio microbiano aislado...
Aceptado junio 2009. ABSTRACT. The aim of this study was to determine the effect of linear alkylbenzene sulfonate (LAS), anthracene and a LAS anthracene mixture on the growth of a microbial consortium isolated from polluted sediment. The microbial consortium was grown in a sterile glass bottle with mineral medium containing 1 g/L of glucose. Microbial growth inhibition produced by LAS, anthracene and combinations of LAS and anthracene was determined by viable count in nutritive agar; inhibitory concentration 50 (IC50) was calculated. The concentrations evaluated were 0.16, 0.8, 1.6, 16 and 160 mg/L of LAS or anthracene. The LAS anthracene mixtures were prepared by fixing either LAS or anthracene at 0.16 mg/L while increasing the other compound at the above concentrations. Microbial growth was sensitive to LAS at an IC50 of 8.22 and to anthracene at an IC50 of 5.2 mg/L. In the LAS anthracene combination, if LAS concentration was fixed and anthracene concentration varied, IC50 (5.92 mg/L) was ...
http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0188-49992010000100004&lng=es&nrm=iso&tlng=en
Dibenz(a,h)anthracene: CAS # 53-70-3 Compound Information and Applications for GC (Gas Chromatography) and LC (Liquid...
Dibenz[a,h]anthracene; Dibenzo[a,h]anthracene; DBA; 1,2:5,6-Benzanthracene; 1,2:5,6-Dibenzanthracene; 1,2:5,6-Dibenzoanthracene; Db(a,h)a; Dibenz(a,h)antracene; 1,2,5,6-Dibenzanthraceen; 1,2:5,6-Dibenz(a)anthracene; 1,2,5,6-Dba; Rcra waste number U063; Dibenzo(a,h)anthracène; 1,2,5,6-Dibenzanthracene; NSC ...
https://ez.restek.com/compound/view/en/53-70-3/Dibenzo%5Ba,h%5Danthracene
Precautions and Warnings With Maprotiline
Before starting maprotiline, be sure to let your doctor know if youve recently had a heart attack. This eMedTV page offers other important precautions and warnings with maprotiline, including possible side effects that may occur.
http://mental-health.emedtv.com/maprotiline/precautions-and-warnings-with-maprotiline-p3.html
Drug Interactions With Maprotiline
When medications like MAOIs or pressors are taken together with maprotiline, drug interactions may occur. This eMedTV page lists other medicines that may cause drug interactions with maprotiline and explains the risks involved with mixing medications.
http://mental-health.emedtv.com/maprotiline/drug-interactions-with-maprotiline-p3.html
2013 November | SRC Signaling
The addition of both MEK1 inhibitor U0126 or JNK inhibitor SP600125 coupled with RI inhibitor SB431542 had no detectable result to the mesenchymal phenotype on the cells. The mixture these details of p38 MAPK inhibitor SB203580 and ROCK inhibitor Y27632 restored cortical actin stain ing, but tension fiber actin remained inside the cells. Escalating the concentration of RI inhibitor SB431542 to ten M led to a even more lessen from the level of anxiety fib ers, nonetheless, the combination of RI inhibitor SB431542 by using a p38 MAPK inhibitor SB203580 or ROCK inhibitor Y27632 was additional effective at getting rid of them. Related results were observed in wild variety mTEC cells, which has a mixture of RI inhibi tor SB431542 and ROCK inhibitor Y27632 reversing EMT as indicated by each gene expression and cell morphology. Collectively, these information indicate that therapy in the cells with RI inhibitor SB431542 by itself are unable to result in total re acqui selleck AZD4547 sition of cortical ...
http://srcsignaling.com/2013/11
1-Hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]anthraquinone - Alfa Chemistry1-Hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]anthraquinone - Alfa Chemistry
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-),please inquire us for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-).
http://www.alfa-chemistry.com/cas_1594-08-7.htm
AMDA - Acid Maltase Deficiency AssociationAMDA - Acid Maltase Deficiency Association
Home , News , About , Research , Patients , Initiatives , Editorials , Links , Contact. Disclaimer: The AMDA does not endorse any of the products, medications, treatments or information reported herein. The website and its contents is intended for informational purposes, only. We strongly advise that you discuss all medications, treatments, and/or products with your physician.. ...
http://www.amda-pompe.org/index.php/main/research/publications/gaa_deficiency_in_pompe_disease_is_alleviated_by_exon_inclusion_in_ipsc-der
Advances in Heterocyclic Chemistry, Vol. 95 by Alan Katritzky - CONFERENCE.PROVOBIS.RO E-booksAdvances in Heterocyclic Chemistry, Vol. 95 by Alan Katritzky - CONFERENCE.PROVOBIS.RO E-books
Transformation of Functional Groups . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 81 81 87 90 92 93 93 95 95 97 98 98 99 100 101 101 101 101 102 102 103 105 106 112 113 114 115 116 116 118 121 122 124 124 124 125 125 126 128 130 132 132 133 133 133 134 Sec. A] 29 PYRAZOL-3-ONES. PART III I. Introduction The present article is Part III of a three part series. In Part I (01AHC(80)73) the synthesis and applications of pyrazol-3-ones I and II are described. G. Of Acyl or Imine Substituted Pyrazol-3-ones . . . . . . . . . . . H. With 1-(3-oxopyrazol-4-yl)-3-substituted Thioureas . . . . . . . . . X. Solvolysis . . . . . . . . . . . . . . . . . . . . . . . . . A. Of Carbonyl and Arylsulfonylpyrazol-3-ones . . . . . . . . . . . B. Of 4-(iminophenylmethyl or phenylaminomethylene)pyrazol-3-ones . . . C. Of (5-oxopyrazol-3-yl)acetamide or 4,4-(dimorpholin-4-yl)pyrazol-3-one . A. With Molecular Oxygen . . . . . . . . . . . . . . . . . . . B. With Bromine or ...
http://conference.provobis.ro/pdf/advances-in-heterocyclic-chemistry-volume-95
2-(2-Methylpropyl)-N-(thietan-3-yl)pyrazol-3-amine | C10H17N3S - PubChem2-(2-Methylpropyl)-N-(thietan-3-yl)pyrazol-3-amine | C10H17N3S - PubChem
2-(2-Methylpropyl)-N-(thietan-3-yl)pyrazol-3-amine | C10H17N3S | CID 130891501 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
https://pubchem.ncbi.nlm.nih.gov/compound/2-_2-Methylpropyl_-N-_thietan-3-yl_pyrazol-3-amine
Molecules of the year - 2019: Topological molecular nanocarbons - All-benzene catenane and trefoil knot. | Henry Rzepas Blog
Here is another molecule of the year, on a topic close to my heart, the catenane systems 1 and the trefoil knot 2 Such topology is closely inter-twinned with
https://www.ch.imperial.ac.uk/rzepa/blog/?p=21631&cpage=1
Amedica Provides Business UpdateAmedica Provides Business Update
SALT LAKE CITY, UT--(Marketwired - Oct 6, 2016) - Amedica Corporation (NASDAQ: AMDA), a biomaterial company that develops and commercializes silicon...
http://www.marketwired.com/news-release/2016/10/06/1087589/0/en/Amedica-Provides-Business-Update.html
anthracene)10 radical anionanthracene)10 radical anion
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
https://webbook.nist.gov/cgi/cbook.cgi?ID=B7379&Units=CAL
CSEMP assessment of anthracene in sediment at station MinchMalin TheMinchSouth se01CSEMP assessment of anthracene in sediment at station MinchMalin TheMinchSouth se01
... accessment of anthracene in sediment (unsieved) at station MinchMalin_TheMinchSouth_se01 (South Minch) from the Marine ... CSEMP assessment of anthracene in sediment at South Minch. Statistical analysis. Trend assessment. Analysis of variance. Df. ... Determinand : Anthracene. Units : μg kg-1 dry weight normalised to 2.5% organic carbon. Data extraction : 30 April 2020. ...
https://www.bodc.ac.uk/projects/data_management/uk/merman/assessments_and_data_access/csemp/assessments/sediment_mnchmln_thmnchs_01_sdmn_ant_.html
Vitamin D postpones the progression of epithelial ovarian cancer induced by 7, 12-dimethylbenz [a] anthracene both in vitro and...Vitamin D postpones the progression of epithelial ovarian cancer induced by 7, 12-dimethylbenz [a] anthracene both in vitro and...
Vitamin D postpones the progression of epithelial ovarian cancer induced by 7, 12-dimethylbenz [a] anthracene both in vitro and ...
https://pubmed.ncbi.nlm.nih.gov/27143932/
Arrangements of fluorophores in the salts of imidazole tethered anthracene derivatives with pyridinedicarboxylic acids...Arrangements of fluorophores in the salts of imidazole tethered anthracene derivatives with pyridinedicarboxylic acids...
Arrangements of fluorophores in the salts of imidazole tethered anthracene derivatives with pyridinedicarboxylic acids ... Arrangements of fluorophores in the salts of imidazole tethered anthracene derivatives with pyridinedicarboxylic acids ...
https://pubs.rsc.org/en/Content/ArticleLanding/2022/MA/D2MA00075J
Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary | ThalesNanoEnantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary | ThalesNano
Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary. 23/11/2018 ... Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary ...
https://thalesnano.com/post_publication/enantioselective-syntheses-of-candenatenins-b-and-c-using-a-chiral-anthracene-auxiliary/
Effects of Dimethylbenz(a)anthracene and Dihydrotestosterone on Estradiol-17β Binding in Rat Mammary Cytosol Fraction1 | Cancer...Effects of Dimethylbenz(a)anthracene and Dihydrotestosterone on Estradiol-17β Binding in Rat Mammary Cytosol Fraction1 | Cancer...
Effects of Dimethylbenz(a)anthracene and Dihydrotestosterone on Estradiol-17β Binding in Rat Mammary Cytosol Fraction1 David D ... Neither 7,12-dimethylbenz(a)anthracene in vivo or in vitro nor dihydrotestosterone in vitro showed significant competition for ... David D. Keightley, Allan B. Okey; Effects of Dimethylbenz(a)anthracene and Dihydrotestosterone on Estradiol-17β Binding in Rat ... Thus the mechanism of action of 7.12-dimethylbenz(a)anthracene in tumorigenesis, or that of dihydrotestosterone in the ...
https://aacrjournals.org/cancerres/article/33/11/2637/479251/Effects-of-Dimethylbenz-a-anthracene-and
Structure-Property Correlations in Luminescent Anthracene DerivativesStructure-Property Correlations in Luminescent Anthracene Derivatives
As a result, the occurring non-covalent interactions between the anthracene moieties could be varied over a broad range. With ... Especially, the formation of the Anthracene excimer in the solid-state was examined comprehensively. The correlations obtained ... This thesis aims to investigate the structure-property relationship of luminescent Anthracene derivatives. For this purpose, ... the Anthracene fluorophore was functionalized in various positions and with different substituents. ...
https://ediss.uni-goettingen.de/handle/11858/13875?locale-attribute=de
Exploring the interaction of anthracene-containing macrocyclic chemosensors with silver(I) and cadmium(II) ions -photophysical...Exploring the interaction of anthracene-containing macrocyclic chemosensors with silver(I) and cadmium(II) ions -photophysical...
Tamayo, A., Oliveira, E., Covelo, B., Casabó, J., Escriche, L., & Lodeiro, C. (2007). Exploring the interaction of anthracene- ... Tamayo, A, Oliveira, E, Covelo, B, Casabó, J, Escriche, L & Lodeiro, C 2007, Exploring the interaction of anthracene- ... keywords = "Anthracene, Cadmium, Chemosensors, Silver, Thiamacrocycles",. author = "Abel Tamayo and Elisabete Oliveira and ... N2 - The four anthracene-containing macrocycles 7-(9anthracenylmethyl)-3, 11 -dithia-7, 17-diazabicyclo[11.3.1]heptadeca1 ( 17 ...
https://novaresearch.unl.pt/en/publications/exploring-the-interaction-of-anthracene-containing-macrocyclic-ch-3
JCDR - Citation Manager Cite this Article Chemopreventive Potential of Myrtenal in 7,12-Dimethylbenz(a) Anthracene Induced...JCDR - Citation Manager Cite this Article Chemopreventive Potential of Myrtenal in 7,12-Dimethylbenz(a) Anthracene Induced...
Chemopreventive Potential of Myrtenal in 7,12-Dimethylbenz(a) Anthracene Induced Experimental Oral Carcinogenesis in Golden ...
https://jcdr.net/citation_mgr.asp?issn=0973-709x&year=2020&month=April&volume=14&issue=4&page=XC01&id=13644
Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands - Kingston University Research RepositorySynthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands - Kingston University Research Repository
The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding ... Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands ... anthracene derivatives as G-quadruplex ligands. RSC Medicinal Chemistry, 5, pp. 751-757. ISSN (online) 2632-8682 ...
https://eprints.kingston.ac.uk/id/eprint/48774/
Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution...
T1 - Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution- ... Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution- ... Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution- ... Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution- ...
https://kyushu-u.pure.elsevier.com/en/publications/synthesis-of-anthracene-derivatives-with-azaacene-containing-ipty
Anti-Smoluchowski time dependence of the delayed fluorescence from anthracene in viscous solution due to triplet-triplet...Anti-Smoluchowski time dependence of the delayed fluorescence from anthracene in viscous solution due to triplet-triplet...
Anti-Smoluchowski time dependence of the delayed fluorescence from anthracene in viscous solution due to triplet-triplet ... Anti-Smoluchowski time dependence of the delayed fluorescence from anthracene in viscous solution due to triplet-triplet ... Nickel, B., Wilhelm, H. E., & Ruth, A. A. (1994). Anti-Smoluchowski time dependence of the delayed fluorescence from anthracene ...
https://pure.mpg.de/pubman/faces/ViewItemFullPage.jsp?itemId=item_601748
Springvalley Chemical Munitions | Public Assessment & Health Consultation | ATSDR
Toxicity was assumed to be similar to anthracene. Concentration below concern for increased cancer or non cancer health effects ...
https://wwwn.cdc.gov/TSP/PHA/PHAHTMLDisplay.aspx?docid=1343&pg=1
The Fluorescence Quenching of Anthracene by Phenothiazine in Sodium Dodecyl Sulfate / Benzyl Alcohol / Water Microemulsion
Anthracene locates in the membrane phase or the oil core of the O/W microemulsion and in the oil continuous phase of the W/O ... The quenching of the excited anthracene by PTZ occurs in the membrane phase either for the W/O microemulsion or for the O/W ... Key words: Sodium dodecyl sulfate, Microemulsion, Benzyl alcohol, Anthracene, Fluorescence quenching, Phenothiazine ... The Fluorescence Quenching of Anthracene by Phenothiazine in Sodium Dodecyl Sulfate / Benzyl Alcohol / Water Microemulsion Guo ...
http://www.whxb.pku.edu.cn/EN/abstract/abstract24290.shtml
ENEN
The results of the recent IARC Monographs evaluation of the carcinogenicity of four agents, including anthracene, 2- ... IARC Monographs evaluate the carcinogenicity of anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite ...
https://www.iarc.who.int/featured-news/iarc-monographs-evaluatacene-2-be-the-carcinogenicity-of-anthrromopropane-butyl-methacrylate-and-dimethyl-hydrogen-phosphite/
Anthracene Oil Market in China 2021 - StrategyHelixAnthracene Oil Market in China 2021 - StrategyHelix
It provides a cohesive picture of the anthracene oil market to help drive informed decision making for industry executives, ... the anthracene oil market in China is expected to grow at a compound annual growth rate (CAGR) of 3.1% over the analysis period ... 4. Anthracene Oil Market by Region. 4.1 Central South China. 4.2 East China. 4.3 North China. 4.4 Northeast China. 4.5 ... The China anthracene oil market is segmented on the basis of region. By region, it is categorized into Central South China, ...
https://strategyh.com/report/anthracene-oil-market-in-china-2021/
Completed Exposure Pathway (CEP) Site Count Report | ATSDRCompleted Exposure Pathway (CEP) Site Count Report | ATSDR
BENZO(A)ANTHRACENE. 110. 55. 56-55-3. 31. BENZO(B)FLUORANTHENE. 104. 46. 205-99-2. ...
http://www.atsdr.cdc.gov/cep/index.html
IMSEAR at SEARO: Inhibitory effect of antioxidants on the benz[a]anthracene-induced oxidative DNA damage in lymphocyte.
Some of the metabolites of benz[a]anthracene are known to be toxic and carcinogenic. In this investigation, benz[a]anthracene- ... Benz[a]anthracene is a ubiquitous environmental contaminant formed during the incomplete combustion of organic material. ... Inhibitory effect of antioxidants on the benz[a]anthracene-induced oxidative DNA damage in lymphocyte. Journal of Environmental ... Inhibitory effect of antioxidants on the benz[a]anthracene-induced oxidative DNA damage in lymphocyte. ...
https://imsear.searo.who.int/handle/123456789/146534?locale=es
Evaluation of the benzo[a]anthracene biodegradation by animal bioassays | Bulletin of the National Research Centre | Full TextEvaluation of the benzo[a]anthracene biodegradation by animal bioassays | Bulletin of the National Research Centre | Full Text
Juhasz AL, Britz ML, Stanley GA (1997) Degradation of fluoranthene, pyrene, benzo(a)anthracene and dibenz(a,h)anthracene by ... Partila, A.M., Mohammed, M.R. Evaluation of the benzo[a]anthracene biodegradation by animal bioassays. Bull Natl Res Cent 43, ... Cooper CS, Ribeiro O, Farmer PB, Hewer A, Walsh C, Pal K et al (1980) The metabolic activation of benz[a]anthracene in hamster ... Benzo[a]anthracene (BAA), also known as "tetraphene" belongs to the polycyclic aromatic hydrocarbons (PAHs) which are ...
https://bnrc.springeropen.com/articles/10.1186/s42269-019-0115-9
Kinematic and dynamical CBED for solving thin organic films at low temperature; experimental tests with anthracene<...
Kinematic and dynamical CBED for solving thin organic films at low temperature; experimental tests with anthracene. / Wu, J. S ... Kinematic and dynamical CBED for solving thin organic films at low temperature; experimental tests with anthracene. Acta ... The approach is tested using experimental data from the centrosymmetric anthracene structure, the results compared with direct ... title = "Kinematic and dynamical CBED for solving thin organic films at low temperature; experimental tests with anthracene", ...
https://www.scholars.northwestern.edu/en/publications/kinematic-and-dynamical-cbed-for-solving-thin-organic-films-at-lo
2-Iododibenzofuran - Carbazole, Anthracene, Aromatic Amine, Pyrene, Thiophene OLED Material
Comparative carcinogenicity of 7-methylbenz[a]anthracene and some of its derivatives at the methyl group - Fingerprint -...
Dive into the research topics of Comparative carcinogenicity of 7-methylbenz[a]anthracene and some of its derivatives at the ... Comparative carcinogenicity of 7-methylbenz[a]anthracene and some of its derivatives at the methyl group. ...
https://experts.nebraska.edu/en/publications/comparative-carcinogenicity-of-7-methylbenzaanthracene-and-some-o/fingerprints/?sortBy=alphabetically
erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis | Med. oral patol. oral...erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis | Med. oral patol. oral...
erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral car ... erbB expression changes in ethanol and 7, 12- dimethylbenz (a) anthracene-induced oral carcinogenesis ...
https://pesquisa.bvsalud.org/portal/resource/pt/ibc-112405
High Pressure X-ray Study on Anthracene - Projekte - Technische Universität GrazHigh Pressure X-ray Study on Anthracene - Projekte - Technische Universität Graz
High Pressure X-ray Study on Anthracene. Martin Oehzelt, Georg Heimel, Roland Resel, P. Puschnig, K. Hummer, C. Ambrosch-Draxl ...
https://graz.pure.elsevier.com/de/publications/high-pressure-x-ray-study-on-anthracene/projects/?status=FINISHED&ordering=title&descending=false
Lack of correlation between in vitro and in vivo replication of precisely defined benz[a]anthracene adducted DNAs<...Lack of correlation between in vitro and in vivo replication of precisely defined benz[a]anthracene adducted DNAs<...
Lack of correlation between in vitro and in vivo replication of precisely defined benz[a]anthracene adducted DNAs. Journal of ... Lack of correlation between in vitro and in vivo replication of precisely defined benz[a]anthracene adducted DNAs. In: Journal ... Using a prokaryotic in vivo replication system, we have shown that both non-bay region anti-trans-benz[a]anthracene adducts are ... Using a prokaryotic in vivo replication system, we have shown that both non-bay region anti-trans-benz[a]anthracene adducts are ...
https://ohsu.pure.elsevier.com/en/publications/lack-of-correlation-between-in-vitro-and-in-vivo-replication-of-p-2
Benzo(a)anthracene-3-hydroxy4834-35-9A2S Reference : H124 - Analytical Standard SolutionsBenzo(a)anthracene-3-hydroxy4834-35-9A2S Reference : H124 - Analytical Standard Solutions
Benzo(a)anthracene-3-hydroxy. 4834-35-9. A2S Reference : H124. 1,1ml (Solution) 100µg/ml Dichloromethane Reference : ...
https://a-2-s.com/products/benzoaanthracene-3-hydroxy
Enantioselective Photodimerization of Anthracene Derivatives in Cyclodextrin Cavity<...
Enantioselective Photodimerization of Anthracene Derivatives in Cyclodextrin Cavity. / Nakamura, Asao; Inoue, Yoshihisa. ... Enantioselective Photodimerization of Anthracene Derivatives in Cyclodextrin Cavity. In: 7th International Conference on ... Nakamura A, Inoue Y. Enantioselective Photodimerization of Anthracene Derivatives in Cyclodextrin Cavity. 7th International ... Nakamura, A., & Inoue, Y. (1999). Enantioselective Photodimerization of Anthracene Derivatives in Cyclodextrin Cavity. 7th ...
https://shibaura.pure.elsevier.com/ja/publications/enantioselective-photodimerization-of-anthracene-derivatives-in-c
Anthracene - anthracene is anthracene, also called paranaphthalene or green oil, a solidAnthracene - anthracene is anthracene, also called paranaphthalene or green oil, a solid
0.5 mg/mL in Acetonitrile Anthracene, 1000 ug/mL in Acetone アントラセン. Anthracene is a solid polycyclic aromatic hydrocarbon (PAH ... 20 Anthracene oil, anthracene paste, anthracene fraction アントラセン油、アントラセンペースト、アントラセン留分 295-275-9 91995-15-2 21 Anthracene oil ... anthracene synonyms, anthracene pronunciation, anthracene translation, English dictionary definition of anthracene. n. A ... Anthracene 1. Anthracene (Anthraquinone)Anthracene (Anthraquinone) GlycosidesGlycosides Anthracene glycosides are oxygenated ...
https://akopensarci.com/science/anthraquinonev-h2388lr-f
DerivativesBenzoPhenanthreneFluorescencePAHsDibenzoDimethylbenzHydrocarbonsAbstractCarcinogenicityVivoBenzeneVitroOrganicUnitsPeakReactionExperimentalToxicStudySolidVolumeBlueRegionStandardProductionProductsResult
Derivatives10
  • This thesis aims to investigate the structure-property relationship of luminescent Anthracene derivatives. (uni-goettingen.de)
  • Coban, Tomris , Robertson, Cameron , Schwikkard, Sianne , Singer, Richard and LeGresley, Adam (2021) Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands. (kingston.ac.uk)
  • The synthesis of a small number of bis(imino)anthracene derivatives is reported. (kingston.ac.uk)
  • In particular, anthracene derivatives are known to exhibit good fluorescence property, with the air stability and solubility in common organic solvents expected to give advantages for solution-processed device fabrication. (elsevier.com)
  • In this study, a series of bistriisopropylsilyl(TIPS)ethynyl anthracene derivatives with azaacene-containing iptycene wings have been synthesized by using condensation reactions. (elsevier.com)
  • Synthesis and Photoelectrical Properties of Two Potential Solution-Processed Blue Fluorescent Emitters Based on Fluorene-Arylamine Derivatives End-Capped with Anthracene/Pyrene Molecules [J]. Acta Phys. (pku.edu.cn)
  • Nakamura, A & Inoue, Y 1999, ' Enantioselective Photodimerization of Anthracene Derivatives in Cyclodextrin Cavity ', 7th International Conference on Circular Dichroism . (elsevier.com)
  • Anthracene derivatives are used in a number of applications. (akopensarci.com)
  • Anthracene D10 2000 microg/mL in Methyl-tert-butyl ethe Anthracene derivatives are useful in preparing stable blue-emitting organic electroluminescence devices. (akopensarci.com)
  • Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). (yyu.edu.tr)
Benzo3
  • Benzo[a]anthracene (BAA), also known as "tetraphene" belongs to the polycyclic aromatic hydrocarbons (PAHs) which are considered as an important class of environmental genotoxins. (springeropen.com)
  • Roberto A, Larsson BS, Tjälve H. Uptake of 7,12-dimethylbenz(a)anthracene and benzo(a)pyrene in melanin-containing tissues. (medscape.com)
  • The investigators examined study participants' urine for three other carcinogens - benz(a)anthracene, benzo(a)pyrene, and 1- hydroxypyrene - but found no significant findings for these molecules. (medscape.com)
Phenanthrene2
  • Phenanthrene is an isomer of anthracene and, as a result, many of the physical properties of the two are very similar. (akopensarci.com)
  • The major differences between anthracene and phenanthrene lie in the melting point and the properties directly related to solubility (Table 13.2). (akopensarci.com)
Fluorescence3
  • The Fluorescence Quenching of Anthracene by Phenothiazine in Sodium Dodecyl Sulfate / Benzyl Alcohol / Water Microemulsion[J].Acta Phys. (pku.edu.cn)
  • Anthracene is colorless but exhibits a blue (400-500 nm peak) fluorescence under ultraviolet radiation Anthracene is not currently considered a toxic substance. (akopensarci.com)
  • In bridged anthracene systems, a novel form of photochromism is observed whereby the sulfur bridge is ejected, resulting in a large increase in fluorescence quantum yield and color that is being investigated for anti-counterfeiting inks. (ubc.ca)
PAHs1
  • Like most PAHs, anthracene is used to make dyes, plastics and pesticides. (akopensarci.com)
Dibenzo1
  • Dibenzo(ah)anthracene (pink) is also carcinogenic. (empa.ch)
Dimethylbenz6
  • Therefore, this study focuses on exploring the chemoprevention of vitamin D on epithelial ovarian cancer induced by 7, 12-dimethylbenz [a] anthracene (DMBA). (nih.gov)
  • Neither 7,12-dimethylbenz(a)anthracene in vivo or in vitro nor dihydrotestosterone in vitro showed significant competition for the estrogen binding sites. (aacrjournals.org)
  • Thus the mechanism of action of 7.12-dimethylbenz(a)anthracene in tumorigenesis, or that of dihydrotestosterone in the inhibition of tumor development, does not involve binding of these compounds to the estrogen receptor. (aacrjournals.org)
  • These alterations involve both the nucleus and cytoplasmic organelles, and are similar to those induced by 7, 12 dimethylbenz [‏a]‏ anthracene in chickens. (who.int)
  • First, I investigated whether prepubertal dietary intake of phytoestrogen genistein in soy foods alters ovarian cancer risk in 7, 12 dimethylbenz(a)anthracene (DMBA) treated mice which model women carriers of germline BRCA1 mutations. (georgetown.edu)
  • ABSTRACT: The aim of the present was study determine the effects of zinc and melatonin on brain tissue (cortex) lipid peroxidation in rats with breast cancer induced by DMBA (7,12-Dimethylbenz[a]anthracene). (karatay.edu.tr)
Hydrocarbons1
  • Like other polycyclic aromatic hydrocarbons, certain metabolites of benz[a]anthracene have been implicated as potent carcinogens. (elsevier.com)
Abstract2
  • abstract = "The four anthracene-containing macrocycles 7-(9anthracenylmethyl)-3, 11 -dithia-7, 17-diazabicyclo[11.3.1]heptadeca1 ( 17), 13, 15-triene (L1), 7-( 10-methyl-9-anthracenylmethyl)-3, 11dithia-7, 17-diazabicyclo[11.3. (unl.pt)
  • abstract = "The 9,10-di(thiophen-2-yl)anthracene (TAT), 9,10-di(furan-2-yl)anthracene (FAF) and 2-[(10-(thiophen-2-yl)anthracen-9-yl)]furan (TAF) cruciform molecular systems were synthesized using one-step coupling reactions and structurally characterized via Raman, infrared, 1H NMR, 13C NMR and mass spectroscopies. (pucv.cl)
Carcinogenicity1
  • The results of the recent IARC Monographs evaluation of the carcinogenicity of four agents, including anthracene, 2-bromopropane, butyl methacrylate, and dimethyl hydrogen phosphite, have now been published in The Lancet Oncology . (who.int)
Vivo2
  • Using a prokaryotic in vivo replication system, we have shown that both non-bay region anti-trans-benz[a]anthracene adducts are essentially nonmutagenic. (elsevier.com)
  • Los experimentos in Vivo de Lai y Singh (1995, 1996) ameritan especial atención, teniendo en cuenta el interés que despertaron. (rfcom.ca)
Benzene1
  • Anthracene is a solid polycyclic aromatic hydrocarbon (PAH) of formula C 14 H 10, consisting of three fused benzene rings. (akopensarci.com)
Vitro1
  • The results demonstrate that antioxidant supplementation to lymphocytes inhibits oxidative DNA damage in vitro, supporting an inhibitory effect against oxidative DNA damage, probably due to reduction of reactive oxygen species production induced by benz[a]anthracene. (who.int)
Organic1
  • Benz[a]anthracene is a ubiquitous environmental contaminant formed during the incomplete combustion of organic material. (who.int)
Units1
  • Secondly, single-crystal X-ray analysis implies that the molecules likely have interactions with the iptycene units of adjacent molecules, while the iptycene wings and TIPSethynyl groups can prevent the central anthracene unit from undesirable non-radiative energy loss. (elsevier.com)
Peak1
  • For this reason, Chromolith® HighResolution columns offer at least 50% higher efficiency than standard Chromolith® columns (exceeding 140,000 plates/meter [Anthracene]), as well as improved peak shape with excellent symmetry. (merckmillipore.com)
Reaction2
  • Photoinduced electron transfer reaction of anthracene with phenothiazine(PTZ)occurs in the membrane phase of the SDS (sodium dodecyl sulfate)/benzyl alcohol/H2O microemulsion. (pku.edu.cn)
  • It forms bis-adducts by [4+2]-cycloaddition reaction with [5,6]-fullerene C 60 anthracene is included in this fact sheet when available. (akopensarci.com)
Experimental1
  • The approach is tested using experimental data from the centrosymmetric anthracene structure, the results compared with direct methods, and a potential map derived from experimental data. (northwestern.edu)
Toxic1
  • Some of the metabolites of benz[a]anthracene are known to be toxic and carcinogenic. (who.int)
Study1
  • To address the molecular mechanisms by which these molecules induce mutations, this study employed oligonucleotides containing four site-specific N 6 adenine-benz[a]anthracene diol epoxide adducts. (elsevier.com)
Solid2
  • Especially, the formation of the Anthracene excimer in the solid-state was examined comprehensively. (uni-goettingen.de)
  • The oil remaining after the removal, by a crystallization process, of an anthracene-rich solid (anthracene paste) from anthracene oil. (europa.eu)
Volume2
  • In terms of volume, the anthracene oil market in China is expected to grow at a compound annual growth rate (CAGR) of 3.1% over the analysis period of 2021 to 2027, according to data and analytics company StrategyHelix. (strategyh.com)
  • The report provides up-to-date market size data for period 2017-2020 and forecast to 2027 covering key market aspects like volume for anthracene oil. (strategyh.com)
Blue2
  • Anthracene is colorless but exhibits a blue. (akopensarci.com)
  • Kinetic Stabilization of Blue‐Emissive Anthracenes: Phenylene Bridging Works Best. (mpg.de)
Region2
  • The China anthracene oil market is segmented on the basis of region. (strategyh.com)
  • In contrast, the bay region anti-trans- benz[a]anthracene lesions do induce point mutations at the adduct site. (elsevier.com)
Standard1
Production2
  • It is a component of coal tar.Anthracene is used in the production of the red dye alizarin and other dyes. (akopensarci.com)
  • Anthracene is used in the production of the red dye alizarin and other dyes L'anthracène est un composé chimique de formule C 14 H 10 synthétisé pour la première fois par Richard Anschütz.C'est un hydrocarbure aromatique polycyclique composé de trois noyaux benzèniques fusionnés en alignement.On l'obtient à partir du goudron.Il est utilisé pour la production industrielle d'alizarine, un pigment rouge naturel d'origine végétale, ainsi que dans les. (akopensarci.com)
Products1
  • Breakdown Products on Metabolic Pathway of Degradation of Benz[A]Anthracene by a Ligninolytic Fungus, Chemosphere, 64, 560-564. (dergipark.org.tr)
Result1
  • As a result, the occurring non-covalent interactions between the anthracene moieties could be varied over a broad range. (uni-goettingen.de)
Setomimycin | Semantic Scholar
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Program Publications: Michigan State University: Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands ...
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