Four fused benzyl rings with three linear and one angular, that can be viewed as a benzyl-phenanthrenes. Compare with NAPHTHACENES which are four linear rings.
A group of compounds with three aromatic rings joined in linear arrangement.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Either of the two longitudinally adjacent threads formed when a eukaryotic chromosome replicates prior to mitosis. The chromatids are held together at the centromere. Sister chromatids are derived from the same chromosome. (Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Compounds based on ANTHRACENES which contain two KETONES in any position. Substitutions can be in any position except on the ketone groups.
Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.
The rate dynamics in chemical or physical systems.
Works about lists of drugs or collections of recipes, formulas, and prescriptions for the compounding of medicinal preparations. Formularies differ from PHARMACOPOEIAS in that they are less complete, lacking full descriptions of the drugs, their formulations, analytic composition, chemical properties, etc. In hospitals, formularies list all drugs commonly stocked in the hospital pharmacy.
Economic aspects of the fields of pharmacy and pharmacology as they apply to the development and study of medical economics in rational drug therapy and the impact of pharmaceuticals on the cost of medical care. Pharmaceutical economics also includes the economic considerations of the pharmaceutical care delivery system and in drug prescribing, particularly of cost-benefit values. (From J Res Pharm Econ 1989;1(1); PharmacoEcon 1992;1(1))
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Regulations to assure protection of property and equipment.
Laws and regulations concerned with industrial processing and marketing of foods.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
Analysis of the energy absorbed across a spectrum of x-ray energies/wavelengths to determine the chemical structure and electronic states of the absorbing medium.
7,12-Dimethylbenzanthracene. Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.
An allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).
A chemical process for separating the components of a liquid mixture by boiling and collecting condensed vapors.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Compounds consisting of two or more fused ring structures.
Benzo-indoles similar to CARBOLINES which are pyrido-indoles. In plants, carbazoles are derived from indole and form some of the INDOLE ALKALOIDS.
An exchange of segments between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. Its frequency is increased by ultraviolet and ionizing radiation and other mutagenic agents and is particularly high in BLOOM SYNDROME.
Inhibits the activity of prostaglandins.
A carcinogen that is often used in experimental cancer studies.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.
A mass of organic or inorganic solid fragmented material, or the solid fragment itself, that comes from the weathering of rock and is carried by, suspended in, or dropped by air, water, or ice. It refers also to a mass that is accumulated by any other natural agent and that forms in layers on the earth's surface, such as sand, gravel, silt, mud, fill, or loess. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1689)
Members of the transforming growth factor superfamily that play a role in pattern formation and differentiation during the pregastrulation and GASTRULATION stages of chordate development. Several nodal signaling ligands are specifically involved in the genesis of left-right asymmetry during development. The protein group is named after a critical region of the vertebrate embryo PRIMITIVE STREAK referred to as HENSEN'S NODE.
Common name for the order Pleuronectiformes. A very distinctive group in that during development they become asymmetrical, i.e., one eye migrates to lie adjacent to the other. They swim on the eyeless side. FLOUNDER, sole, and turbot, along with several others, are included in this order.
Compounds that contain two halogenated benzene rings linked via an OXYGEN atom. Many polybrominated diphenyl ethers are used as FLAME RETARDANTS.
Biphenyl compounds which are extensively brominated. Many of these compounds are toxic environmental pollutants.

Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (1/915)

Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators.  (+info)

Formation of bound residues during microbial degradation of [14C]anthracene in soil. (2/915)

Carbon partitioning and residue formation during microbial degradation of polycyclic aromatic hydrocarbons (PAH) in soil and soil-compost mixtures were examined by using [14C]anthracenes labeled at different positions. In native soil 43.8% of [9-14C]anthracene was mineralized by the autochthonous microflora and 45.4% was transformed into bound residues within 176 days. Addition of compost increased the metabolism (67.2% of the anthracene was mineralized) and decreased the residue formation (20. 7% of the anthracene was transformed). Thus, the higher organic carbon content after compost was added did not increase the level of residue formation. [14C]anthracene labeled at position 1,2,3,4,4a,5a was metabolized more rapidly and resulted in formation of higher levels of residues (28.5%) by the soil-compost mixture than [14C]anthracene radiolabeled at position C-9 (20.7%). Two phases of residue formation were observed in the experiments. In the first phase the original compound was sequestered in the soil, as indicated by its limited extractability. In the second phase metabolites were incorporated into humic substances after microbial degradation of the PAH (biogenic residue formation). PAH metabolites undergo oxidative coupling to phenolic compounds to form nonhydrolyzable humic substance-like macromolecules. We found indications that monomeric educts are coupled by C-C- or either bonds. Hydrolyzable ester bonds or sorption of the parent compounds plays a minor role in residue formation. Moreover, experiments performed with 14CO2 revealed that residues may arise from CO2 in the soil in amounts typical for anthracene biodegradation. The extent of residue formation depends on the metabolic capacity of the soil microflora and the characteristics of the soil. The position of the 14C label is another important factor which controls mineralization and residue formation from metabolized compounds.  (+info)

Diverse oxygenations catalyzed by carbazole 1,9a-dioxygenase from Pseudomonas sp. Strain CA10. (3/915)

Carbazole 1,9a-dioxygenase (CARDO) from Pseudomonas sp. strain CA10 is a multicomponent enzyme that catalyzes the angular dioxygenation of carbazole, dibenzofuran, and dibenzo-p-dioxin. It was revealed by gas chromatography-mass spectrometry and 1H and 13C nuclear magnetic resonance analyses that xanthene and phenoxathiin were converted to 2,2',3-trihydroxydiphenylmethane and 2,2',3-trihydroxydiphenyl sulfide, respectively. Thus, for xanthene and phenoxathiin, angular dioxygenation by CARDO occurred at the angular position adjacent to the oxygen atom to yield hetero ring-cleaved compounds. In addition to the angular dioxygenation, CARDO catalyzed the cis dihydroxylation of polycyclic aromatic hydrocarbons and biphenyl. Naphthalene and biphenyl were converted by CARDO to cis-1, 2-dihydroxy-1,2-dihydronaphthalene and cis-2,3-dihydroxy-2, 3-dihydrobiphenyl, respectively. On the other hand, CARDO also catalyzed the monooxygenation of sulfur heteroatoms in dibenzothiophene and of the benzylic methylenic group in fluorene to yield dibenzothiophene-5-oxide and 9-hydroxyfluorene, respectively. These results indicate that CARDO has a broad substrate range and can catalyze diverse oxygenation: angular dioxygenation, cis dihydroxylation, and monooxygenation. The diverse oxygenation catalyzed by CARDO for several aromatic compounds might reflect the differences in the binding of the substrates to the reaction center of CARDO.  (+info)

Comparative tumorigenicity of the cyclopenta-fused polycyclic aromatic hydrocarbons aceanthrylene, dihydroaceanthrylene and acephenanthrylene in preweanling CD-1 and BLU:Ha mouse bioassays. (4/915)

Cyclopenta-fused polycyclic aromatic hydrocarbons are ubiquitous environmental pollutants and potential human health biohazards. In this study, the tumorigenicity of three single cyclopenta-fused polycyclic aromatic hydrocarbons, aceanthrylene, dihydroaceanthrylene and acephenanthrylene, was examined in preweanling CD-1 and BLU:Ha mouse bioassays at total doses of 175, 437.5 and 875 micrograms/mouse. No death or significant toxicity was observed with the treatment protocol in the tested animals. In CD-1 mice, a significant increase in lung tumor incidence (18-26%, P < 0. 025-0.01) for these three compounds was recorded in animals treated with 875 micrograms as compared with the control animals (3%). Significant numbers of liver tumors (25-41%, P < 0.01-0.001) were induced in all aceanthrylene treatment groups and in animals treated with 875 micrograms acephenanthrylene (35%) at the termination at 9 months. Most liver tumors were induced in male animals. The ED50 values were estimated as 8.5, 10.6 and 12.8 micromol and the TM1.0 were 15.1, 20.4 and 23.1 micromol for aceanthrylene, acephenanthrylene and dihydroaceanthrylene, respectively. In BLU:Ha mice, there was a significant dose-dependent increase in lung tumor incidence, from 4% for the control group to 33% (P < 0.001) for the animals treated with 875 micrograms aceanthrylene and to 24% (P < 0.02) for the animals treated with 437.5 micrograms acephenanthrylene. The ED50 values were 6.0 and 4.4 micromol and the TM1.0 were 9.8 and 6.8 micromol for aceanthrylene and acephenanthrylene, respectively. No significant difference in lung tumor incidence between male and female mice was found. Based on these data and comparisons of tumorigenic potency with other polycyclic aromatic hydrocarbons previously tested in these newborn mouse bioassays, aceanthrylene and acephenanthrylene were classified as weak tumorigens.  (+info)

Myeloma cells selected for resistance to CD95-mediated apoptosis are not cross-resistant to cytotoxic drugs: evidence for independent mechanisms of caspase activation. (5/915)

We have previously shown that selection for resistance to the anthracenes, doxorubicin or mitoxantrone, results in coselection for resistance to CD95-mediated apoptosis (Landowski et al: Blood 89:1854, 1997). In the present study, we were interested in determining if the converse is also true; that is, does selection for CD95 resistance coselect for resistance to chemotherapeutic drugs. To address this question, we used two isogenic models of CD95-resistant versus CD95-sensitive cell lines: 8226/S myeloma cells selected for resistance to CD95-mediated apoptosis; and K562 cells expressing ectopic CD95. Repeated exposure of the CD95-sensitive human myeloma cell line, 8226/S, to agonistic anti-CD95 antibody resulted in a cell line devoid of CD95 receptor surface expression and completely resistant to CD95-mediated apoptosis. Multiple clonal populations derived from the CD95-resistant cell line showed no difference in sensitivity to doxorubicin, mitoxantrone, Ara-C, or etoposide, demonstrating that cross-resistance between Fas-mediated apoptosis and drug-induced apoptosis occurs only when cytotoxic drugs are used as the selecting agent. Using the inverse approach, we transfected the CD95-negative cell line, K562, with a CD95 expression vector. Clones expressing variable levels of cell-surface CD95 were isolated by limiting dilution, and analyzed for sensitivity to CD95-mediated apoptosis and response to chemotherapeutic drugs. We show that CD95 surface expression confers sensitivity to CD95-mediated apoptosis; however, it does not alter response to chemotherapeutic drugs. Similarly, doxorubicin-induced activation of caspases 3 and 8 was identical in the CD95-sensitive and CD95-resistant cell lines in both isogenic cell systems. In addition, prior treatment with the CD95 receptor-blocking antibody, ZB4, inhibited CD95-activated apoptosis in 8226/S cells, but had no effect on doxorubicin cytotoxicity. These results show that CD95 and chemotherapeutic drugs use common apoptotic effectors, but the point of convergence in these two pathways is downstream of CD95 receptor/ligand interaction.  (+info)

Development of a new bioluminescent mutagenicity assay based on the Ames test. (6/915)

A newly developed rapid mutagenicity assay based on the adenosine triphosphate (ATP)-bioluminescence technique and the Ames test is described. Salmonella typhimurium strains TA98 and TA100 were exposed in an appropriate liquid medium to the direct mutagens 4-nitroquinoline-N-oxide and methyl methanesulphonate, respectively, and to the indirect mutagen 2-aminoanthracene. Both auxotrophic and prototrophic growth were monitored throughout the incubation period as variations in the intracellular ATP levels by means of the luciferin-luciferase assay. After 9-12 h of incubation a dose-response increase in the levels of ATP was readily detected. In order to demonstrate that this increase was due to the growth of revertant bacteria, aliquots from each culture were plated on minimal agar plates. A very good correlation between the changes in ATP levels and the appearance of revertant colonies on the plates was found. Given the rapidity of this method as compared with conventional mutagenicity assays, it has potential for industrial and environmental applications. Other potential applications are also discussed.  (+info)

Polycyclic aromatic hydrocarbon metabolism by white rot fungi and oxidation by Coriolopsis gallica UAMH 8260 laccase. (7/915)

We studied the metabolism of polycyclic aromatic hydrocarbons (PAHs) by using white rot fungi previously identified as organisms that metabolize polychlorinated biphenyls. Bran flakes medium, which has been shown to support production of high levels of laccase and manganese peroxidase, was used as the growth medium. Ten fungi grown for 5 days in this medium in the presence of anthracene, pyrene, or phenanthrene, each at a concentration of 5 microg/ml could metabolize these PAHs. We studied the oxidation of 10 PAHs by using laccase purified from Coriolopsis gallica. The reaction mixtures contained 20 microM PAH, 15% acetonitrile in 60 mM phosphate buffer (pH 6), 1 mM 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS), and 5 U of laccase. Laccase exhibited 91% of its maximum activity in the absence of acetonitrile. The following seven PAHs were oxidized by laccase: benzo[a]pyrene, 9-methylanthracene, 2-methylanthracene, anthracene, biphenylene, acenaphthene, and phenanthrene. There was no clear relationship between the ionization potential of the substrate and the first-order rate constant (k) for substrate loss in vitro in the presence of ABTS. The effects of mediating substrates were examined further by using anthracene as the substrate. Hydroxybenzotriazole (HBT) (1 mM) supported approximately one-half the anthracene oxidation rate (k = 2.4 h(-1)) that ABTS (1 mM) supported (k = 5.2 h(-1)), but 1 mM HBT plus 1 mM ABTS increased the oxidation rate ninefold compared with the oxidation rate in the presence of ABTS, to 45 h(-1). Laccase purified from Pleurotus ostreatus had an activity similar to that of C. gallica laccase with HBT alone, with ABTS alone, and with 1 mM HBT plus 1 mM ABTS. Mass spectra of products obtained from oxidation of anthracene and acenaphthene revealed that the dione derivatives of these compounds were present.  (+info)

Nepalolide A inhibits the expression of inducible nitric oxide synthase by modulating the degradation of IkappaB-alpha and IkappaB-beta in C6 glioma cells and rat primary astrocytes. (8/915)

1 The effects of nepalolide A on the expression of inducible nitric oxide synthase (iNOS) caused by incubation with lipopolysaccharide/interferon-gamma (LPS/IFN-gamma) or tumour necrosis factor-alpha/interleukin-1beta/IFN-gamma (TNF-alpha/IL-1beta/IFN-gamma, mixed cytokines) in C6 glioma cells and primary astrocytes of rat were investigated. The mechanisms by which nepalolide A confers its effect on iNOS expression were also elucidated. 2 Treatment with LPS/IFN-gamma and mixed cytokines for 24 h elicited the induction of iNOS activity as determined by nitrite accumulation in the culture medium and assay of enzyme activity. Nepalolide A at 10 microM abrogated the LPS/IFN-gamma- and mixed cytokines-mediated induction of iNOS by more than 90% in C6 glioma cells, and by 80% for mixed cytokines-induced induction of iNOS in primary astrocytes. The effect of nepalolide A (2-10 microM) was concentration-dependent. 3 The inhibition of iNOS induction by nepalolide A was attributed to decreases in the content of iNOS protein and the level of iNOS mRNA, as measured by immunoblotting and reverse transcriptase-polymerase chain reaction. 4 Electrophoretic mobility shift assay was used to evaluate the effect of nepalolide A on the activation of nuclear factor-kappaB (NF-kappaB). Results showed that nepalolide A diminished the LPS/IFN-gamma-mediated association of NF-kappaB with consensus oligonucleotide in a concentration-dependent manner. The activation of NF-kappaB by mixed cytokines was modulated both in the extent of activation and in its time-course by nepalolide A. 5 The ability of nepalolide A to inhibit NF-kappaB activation was further confirmed by studies on the degradation of the inhibitor of NF-kappaB, IkappaB, as measured by immunoblotting. 6 The present study demonstrates that the attenuation of NF-kappaB activation by nepalolide A was mediated by blockade of the degradation of IkappaB, leading to suppression of the expression of iNOS.  (+info)

9,10-Dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylic acid - chemical information, properties, structures, articles, patents and more chemical data.
The dimer, called dianthracene (or sometimes paranthracene), is connected by a pair of new carbon-carbon bonds, the result of the [4+4] cycloaddition. It reverts to anthracene thermally or with UV irradiation below 300 nm. The reversible dimerization and the photochromic properties of anthracenes are the basis of potential applications.[11] Substituted anthracene derivatives behave similarly. The reaction is affected by the presence of oxygen. In general, reduction of anthracene yields 9,10-dihydroanthracene (destroying the aromaticity of the center ring) rather than 1,4-dihydroanthracene (which would destroy the aromaticity of one of the terminal rings). This preference for reduction at the 9 and 10 positions is explained by the fact that aromatic stabilization energy is directly correlated with the number of conjugated pi bonds in an aromatic system. Since 9,10-dihydroanthracene in essence preserves two benzene rings (a total of 6 conjugated pi bonds), whereas the 1,4-isomer preserves only ...
The oxidative dehydrogenation of dihydroarenes catalyzed by 2,3-dichloro-5,6-dicyano-benzoquinone(DDQ) and NaNO2 with dioxygen is reported. The combination of DDQ and NaNO2 showed high efficiency and high selectivity, compared with other benzoquinones and anthraquinones, e.g., |99% conversion of 9,10-dihydroanthracene with 99% selectivity for anthracene can be obtained at 120 °C under 1.3 MPa O2 for 8 h. Excellent results were achieved in the oxidative dehydrogenation of variety of dihydroarenes.
You are viewing an interactive 3D depiction of the molecule anthra[2,1,9-def:6,5,10-def]diisoquinoline-1,3,8,10(2h,9h)-tetrone, 2,9-dimethyl- (C26H34N2O4) from the PQR.
Summary of Facts and Submissions. I. The Appellant (Opponent) lodged an appeal against the interlocutory decision of the Opposition Division which found that the European patent No. 1 553 154 amended according to the then pending auxiliary request 1 met the requirements of the EPC.. II. Notice of opposition had been filed by the Appellant requesting revocation of the patent in suit in its entirety on the grounds of lack of novelty and inventive step (Article 100(a) EPC) and insufficient disclosure (Article 100(b) EPC). Inter alia the following documents were submitted in the opposition proceedings:. (1) EP-A-0 857 007,. (2) EP-A-1 009 044 and. (3) EP-A-1 167 488.. III. According to the Opposition Division, the specification of the patent-in-suit contained sufficient information to enable the skilled person to carry out the invention across the whole breadth of the claims. Contrary to the assertion of the opponent, the wording asymmetric anthracene derivative represented by the formula (2) gave ...
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CONTROLLED LABS - Blue GrowtH™ FAQ & Write up What is Blue GrowtH™ ? Key Attributes: - Serum GH level enhancement - Deeper, more
TY - JOUR. T1 - Synthesis of Anthracene Derivatives with Azaacene-Containing Iptycene Wings and the Utilization as a Dopant for Solution-Processed Organic Light-Emitting Diodes. AU - Hayashi, Hironobu. AU - Kato, Yuki. AU - Matsumoto, Akinobu. AU - Shikita, So. AU - Aizawa, Naoya. AU - Suzuki, Mitsuharu. AU - Aratani, Naoki. AU - Yasuda, Takuma. AU - Yamada, Hiroko. N1 - Funding Information: This work was partly supported by CREST JST (No. JPMJCR15F1) and Grants‐in‐Aid for Scientific Research (Nos. JP26105004, JP26288038, JP17H03042, JP19K22112, JP19H04584, JP16H02286, and JP18K14190). We thank Ms. Y. Nishikawa, NAIST for the mass spectroscopy measurements. Funding Information: This work was partly supported by CREST JST (No. JPMJCR15F1) and Grants-in-Aid for Scientific Research (Nos. JP26105004, JP26288038, JP17H03042, JP19K22112, JP19H04584, JP16H02286, and JP18K14190). We thank Ms. Y. Nishikawa, NAIST for the mass spectroscopy measurements. Publisher Copyright: © 2019 Wiley-VCH Verlag ...
The influence of peptide sequence and Leu chirality in linear and cyclic peptides containing 3-[2-(9-anthryl)benzoxazol-5-yl]alanine on interaction with β-cyclodextrin were studied using fluorescence and NMR spectroscopy. The analysis of enthalpy-entropy compensation effect (α=1.05±0.02 and TΔS00=15.1±0.5 kJ mol−1) indicates that the entropic contribution connected with the solvent reorganization is the major factor governing the peptides-β-cyclodextrin complexation. Moreover, spatial orientation of guest-host molecule depends more than association constant on Leu residue configuration. However, the cyclization of the peptide chain substantially decrease the association constant with β-CD. An analysis of 2D NMR spectra reveals that inclusion complex is formed by penetration of cyclodextrin cavity from wider and narrow rims by anthryl group in the case of Box(Ant)-SPKL or anthryl and Leu residues for Box(Ant)-SPK(D)L analogue ...
In the present study, we clarified the molecular mechanism underlying the relationship between benzyl isothiocyanate (BITC)-induced cell cycle arrest and apoptosis and the involvement of mitogen-activated protein kinases (MAPKs). The exposure of Jurkat human T-cell leukemia cells to BITC resulted in the inhibition of the G2-M progression that coincided with the apoptosis induction. The experiment using the phase-specific synchronized cells demonstrated that the G2-M phase-arrested cells are more sensitive to undergoing apoptotic stimulation by BITC than the cells in other phases. We also confirmed that BITC activated c-Jun N-terminal kinase (JNK) and p38 MAPK, but not extracellular signal-regulated kinase, at the concentration required for apoptosis induction. An experiment using a JNK-specific inhibitor SP600125 or a p38 MAPK inhibitor SB202190 indicated that BITC-induced apoptosis might be regulated by the activation of these two kinases. Conversely, BITC is likely to confine the Jurkat cells ...
The dimer is connected by two covalent bonds resulting from the [4+4] cycloaddition. The dimer reverts to anthracene thermally or with UV irradiation below 300 nm. The reversible bonding and photochromic properties of anthracenes are the basis of many potential applications using poly and monosubstituted anthracene derivatives. The reaction is sensitive to oxygen.. In most other reactions of anthracene, the central ring is also targeted, as it is the most highly reactive. Electrophilic substitution occurs at the 9 and 10 positions of the center ring, and oxidation of anthracene occurs readily, giving anthraquinone, C14H8O2 (below).. ...
Filatov, M. A. (Creator), Karuthedath, S. (Creator), Polestshuk, P. M. (Creator), Savoie, H. (Creator), Flanagan, K. J. (Creator), Sy, C. (Creator), Sitte, E. (Creator), Telitchko, M. (Creator), Laquai, F. (Creator), Boyle, R. W. (Creator), Senge, M. O. (Creator), Filatov, M. A. (Creator), Polestshuk, P. M. (Creator), Savoie, H. (Creator), Flanagan, K. J. (Creator), Sy, C. (Creator), Sitte, E. (Creator), Telitchko, M. (Creator), Boyle, R. W. (Creator), Senge, M. O. (Creator) (Aug 9 2017). CCDC 1526053: Experimental Crystal Structure Determination : 5,5-difluoro-1,3,7,9-tetramethyl-10-(10-methyl-9-anthryl)-5H-6,5-dipyrrolo[1,2-c:2,1-f][1,3,2]diazaborinine. Cambridge Crystallographic Data Centre. 10.5517/ccdc.csd.cc1n6zjc ...
Bioactivity-directed fractionation of an extract of the leaves of Alvaradoa haitiensis, using the KB (human oral epidermoid carcinoma) cell line, led to the isolation and identification of 10 new anthracenone C-glycosides, alvaradoins E?N (1?10), along with the known compound chrysophanol (11). The cytotoxicity of all compounds was evaluated, and preliminary structure?activity
Procedure 1.Add 2mL samples or standards [0(pure water), 5, 10, 25, 50, 80µg/2mL] solution into all prepared test tubes. 2.(In chemical hood) Use glass pipette and gently add 0.5mL 2% anthrone solution into each test tube. There will be two layers of this solution. The upper layer is anthrone and the lower layer is the sample/standard. Try not to disturb solution, because ethyl acetate is easy to vaporize. 3.(In chemical hood) Use glass pipette to add 5mL concentrated sulfuric acid into the tube gently. Put the tip of pipette into the bottom of lower layer. Concentrated sulfuric acid will vaporize ethyl acetate immediately if you drop this sulfuric acid on it. [SAFETY NOTES: sulfuric acid is highly hazardous (corrosive, irritant). Be sure to wear gloves and prevent direct contact.] (The test tube will be very hot after sulfuric acid is added. Hold the higher part of test tube to prevent burning your fingers) 4.(In chemical hood) Swirl gently and youll see the vaporization of ethyl acetate. ...
What do experimentally measured kinetic isotope effects (KIEs) tell us about H-abstraction reactions with multispin-state reactivity options? Using DFT calculations with tunneling corrections for experimentally studied H-abstraction reactions of porphyrin-Compound II species (Chem.-Eur. J. 2014, 20, 14437; Angew. Chem., Int. Ed. 2008, 47, 7321) with cyclohexane, dihydroanthracene (DHA), and xanthene (Xan), we show here that KIE is a selective probe that identifies the experimentally reactive spi
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Name: CA Name: Anthracene Molecular Structure: Anthracene,CAS 120-12-7,178.23,C14H10 Anthracene,CAS 120-12-7,178.23,C14H10 Molecular Formula:C14H10 Molecular Weight: 178.23 CAS Registry Number: 120-12-7
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
In October 2011 the EU commission published a recommendation (2011/696/EU) on the definition of nanomaterials. Standardised and certified methodologies (which are essential for accurate material characterisation, comparison and categorisation) to accompany this recommendation are now in development. From the results of analysis by the non-standardised methods currently available, it is conceivable that the substance subject to registration could be considered as falling within the boundaries of the nanomaterial definition. ...
Guidance from The Society For Post-Acute And Long-Term Care Medicine (AMDA), who are closely monitoring the COVID-19 (novel coronavirus) outbreak.
Name:C.I.Solvent Red 149,C.I.674700 Molecular Structure: Pyrimidine Anthrone C.I.Solvent Red 149,C.I.674700,CAS 71902-18-6,358.43,C23H22N2O2,Solvent Red G,Transparent Red G,Fluorescent Red HFG,Oil Red 149 C.I.Solvent Red 149,C.I.674700,CAS 71902-18-6,358.43,C23H22N2O2,Solvent Red G,Transparent Red G,Fluorescent Red HFG,Oil Red 149 Molecular Formula:C23H22N2O2 Molecular Weight: 358.43 CAS Registry Number:71902-18-6
0261]Blue-green to green light emission can be obtained, for example, by using a coumarin dye such as coumarin 30 or coumarin 6, bis[2-(2,4-difluorophenyl)pyridinato]picolinatokidium (abbreviation: FIrpic), bis(2-phenylpyridinato)acetylacetonatoiridium (abbreviation: Ir(ppy)2(acac)), or the like as a guest material and dispersing the guest material in a suitable host material. Further, blue-green to green light emission can be obtained by dispersing perylene or TBP, which are mentioned above, in a suitable host material at a high concentration of 5 wt % or more. Further alternatively, blue-green to green light emission can be obtained from a metal complex such as BAlq, Zn(BTZ)2, or bis(2-methyl-8-quinolinolato)chlorogallium (Ga(mq)2Cl). Further, a polymer such as poly(p-phenylenevinylene) may be used. Further, an anthracene derivative is preferable as a guest material of a blue-green to green light-emitting layer, as high light-emitting efficiency can be obtained when an anthracene derivative is ...
The structure-based design and synthesis of a novel series of c-Jun N-terminal kinase (JNK) inhibitors with selectivity against p38 is reported. The unique structure of 3,5-disubstituted quinolines (2) was developed from the previously reported 4-(2,7-phenanthrolin-9-yl)phenol (1). The X-ray crystal structure of 16a in JNK3 reveals an unexpected binding mode for this new scaffold with protein ...
29311-94-2 - SYZOCKFTUCTLFQ-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,4-bis((3-chloro-2-hydroxypropyl)amino)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
55345-44-3 - QFYZUUMEXXFCKY-UHFFFAOYSA-N - 9,10-Anthracenedione, 1,5-bis((4-phenoxyphenyl)amino)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
2-(Pyrazol-5-yl)phenol 34810-67-8 MSDS report, 2-(Pyrazol-5-yl)phenol MSDS safety technical specifications search, 2-(Pyrazol-5-yl)phenol safety information specifications ect.
4-(pyrazol-1-ylmethyl)benzoic acid 160388-53-4 NMR spectrum, 4-(pyrazol-1-ylmethyl)benzoic acid H-NMR spectral analysis, 4-(pyrazol-1-ylmethyl)benzoic acid C-NMR spectral analysis ect.
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Synthesis How to make a great presentation in powerpoint novel sugar or azasugar analog anthra[1,2- d ] imidazole-6,dione derivatives and interesting evaluation.
of just one 1,000 U/ml, and one protease inhibitor tablet/50ml (Roche Cat #04693132001). On the other hand, the goals of antibodies in the same mice […]. Continue reading ...
JNK signaling is known to play a role in regulating cell behaviors such as cell cycle progression, cell proliferation, and apoptosis, and recent studies have suggested important roles for JNK signaling in embryonic development. However, the precise function of JNK signaling in hair cell development remains poorly studied. In this study, we used the small molecule JNK inhibitor SP600125 to examine the effect of JNK signaling abrogation on the development of hair cells in the zebrafish lateral line neuromast. Our results showed that SP600125 reduced the numbers of both hair cells and supporting cells in neuromasts during larval development in a dose-dependent manner. Additionally, JNK inhibition strongly inhibited the proliferation of neuromast cells, which likely explains the decrease in the number of differentiated hair cells in inhibitor-treated larvae. Furthermore, western blot and in situ analysis showed that JNK inhibition induced cell cycle arrest through induction of p21 expression. We also showed
A synthesis of the spirocyclopente-dione anthracene adduct, a precursor of the cyclopentenone prostaglandins has been reported. The synthesis involved a Diels-Alder reaction of anthracene and dimethyl fumarate to afford 3 followed by reduction, oxidation and esterification reactions to provide methyl ester anthracene adduct 8, which further converted to the the allylic alcohol (12). Then, Ring-Closing Metathesis (RCM) reaction afforded the cyclopentenol anthracene adduct, which after oxidation provided the spirocyclopente-dione anthracene adduct in good yields.
The pathophysiology of a traumatic brain injury (TBI) involves the dysfunction of the blood-brain barrier (BBB). The lumen of the BBB is lined with cerebrovascular endothelial cells (CVEC) that are ensheathed with perivascular astrocyte endfeet. We investigated the cellular response of human-astrocytes and human-CVEC following trauma in vitro. Astrocytes and CVEC were subjected to a concussive injury (CI; mechanical stretch), then assessed for markers of injury (monolayer retraction) and activation (mitogen-activated protein kinases (MAPK) phosphorylation). CI induces astrocyte monolayer retraction and activation, with predominant phosphorylation of JNK1/2 MAPK. Interfering with JNK1/2 activation (selective JNK inhibitors) reduces trauma-induced astrocyte retraction. On the contrary, CI does not induce CVEC retraction, however up-regulates CVEC pro-adhesive phenotype resulting in increased polymorphonuclear leukocyte (PMN) adhesion. These findings indicate that CI elicits differential BBB cell responses
The drug is not recommended for use in children. The possibility of suicide in seriously depressed patients is inherent in their illness and may persist until significant remission occurs. Therefore, patients must be carefully supervised during all phases of treatment with maprotiline and prescriptions should be written for the smallest amount consistent with good management. Safe use of Maprotiline during pregnancy or lactation has not been established; therefore, its use in pregnancy, in nursing mothers or in women of childbearing potential requires that the benefits of treatment be weighed against the possible risks to mother and child. Patients should be kept under medical surveillance during treatment with maprotiline. The dosage of maprotiline should be individualized according to the requirements of each patient. Do not share this medicine with others for whom it was not prescribed. Do not use this medicine for other health conditions. After you stop taking this medicine, your body will ...
Angiotensin II (ANG II) has been implicated in the pathogenesis of diabetic micro- and macrovascular disease. In vascular smooth muscle cells (VSMCs), ANG II phosphorylates and degrades insulin receptor substrate-1 (IRS-1). While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH2-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. We investigated the role of JNK in ANG II-induced IRS-1 phosphorylation, degradation, Akt activation, glucose uptake, and hypertrophic signaling, focusing on three IRS-1 phosphorylation sites: Ser302, Ser307, and Ser632. Maximal IRS-1 phosphorylation on Ser632 occurred at 5 min, on Ser307 at 30 min, and on Ser302 at 60 min. The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). However, JNK inhibition had no effect on ANG II-mediated IRS-1 degradation, nor did it reverse the ...
Angiotensin II (ANG II) has been implicated in the pathogenesis of diabetic micro- and macrovascular disease. In vascular smooth muscle cells (VSMCs), ANG II phosphorylates and degrades insulin receptor substrate-1 (IRS-1). While the pathway responsible for IRS-1 degradation in this system is unknown, c-Jun NH2-terminal kinase (JNK) has been linked with serine phosphorylation of IRS-1 and insulin resistance. We investigated the role of JNK in ANG II-induced IRS-1 phosphorylation, degradation, Akt activation, glucose uptake, and hypertrophic signaling, focusing on three IRS-1 phosphorylation sites: Ser302, Ser307, and Ser632. Maximal IRS-1 phosphorylation on Ser632 occurred at 5 min, on Ser307 at 30 min, and on Ser302 at 60 min. The JNK inhibitor SP600125 reduced ANG II-induced IRS-1 Ser307 phosphorylation (by 80%), IRS-1 Ser302 phosphorylation (by 70%), and IRS-1 Ser632 phosphorylation (by 50%). However, JNK inhibition had no effect on ANG II-mediated IRS-1 degradation, nor did it reverse the ...
Chrysarobin definition, a mixture of compounds obtained from Goa powder, used in the treatment of psoriasis and other skin conditions. See more.
Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix kaempferi Gorden, has antifungal activity. - Mechanism of Action & Protocol.
This graph shows the total number of publications written about Maprotiline by people in Harvard Catalyst Profiles by year, and whether Maprotiline was a major or minor topic of these publication ...
TheK i values of Cibacron blue, chrysin, 7,8-dihydroxyflavone, phenindone, and dicoumarol to rY128D, rG150V, and hH161Q were significantly greater than those for the wild-type human enzymes, indicating that Tyr128, Gly150, and His161 are situated in the binding pockets of these inhibitors. On the other hand, Tyr155 and His194 are probably not in direct contact with the inhibitors, because the binding of inhibitors are not affected by Tyr155 to Phe and His194 to Asp mutations.. The X-ray structure of Cibacron blue bound to rat DT-diaphorase has been published (Li et al., 1995) and was used to help interpret the results of our inhibition studies. The binding of Cibacron blue is significantly reduced by the Tyr128 to Asp mutation and the Gly150 to Val mutation. The K i values of Cibacron blue for rY128D and rG150V are 110 and 23 times that for the wild-type rat DT-diaphorase, respectively. The X-ray structural analysis revealed that the inhibitors trizaine ring is sandwiched between these two ...
0037] Mention may also be made, as pyrazole derivatives, of diamino-N,N-dihydropyrazolopyrazolones and in particular those described in application FR-A-2 886 136, such as the following compounds and the addition salts thereof: 2,3-diamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-ethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-isopropylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one, 2-amino-3-(pyrrolidin-1-yl)-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-on- e, 4,5-diamino-1,2-dimethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-diethyl-1,2-dihydropyrazol-3-one, 4,5-diamino-1,2-di(2-hydroxyethyl)-1,2-dihydropyrazol-3-one, 2-amino-3-(2-hydroxyethyl)amino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-- 1-one, 2-amino-3-dimethylamino-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-- one, 2,3-diamino-5,6,7,8-tetrahydro-1H,6H-pyridazino[1,2-a]pyrazol-1-one, 4-amino-1,2-diethyl-5-(pyrrolidin-1-yl)-1,2-dihydropyrazol-3-one, ...
SunPower Corporation (NASDAQ:SPWR) (Full FREE Analysis of SPWR And Be Sure To Notice The Intermediate Period) declared its change time of third-quarter 2013 results conference call to 5:30 a.m. PT on Oct. 29, 2014. Due to conflicts in executives schedules, SunPower will now hold its third-quarter financial results conference call on Wednesday, Oct. 29 at […]
Name:C.I.Solvent Red 114,C.I.68415 Molecular Structure: Pyrimidine Anthrone C.I.Solvent Red 114,C.I.68415,CAS 12226-90-3,511.36,C28H16Cl2N4O2,Fluorescent Red Orange 62365 C.I.Solvent Red 114,C.I.68415,CAS 12226-90-3,511.36,C28H16Cl2N4O2,Fluorescent Red Orange 62365 Molecular Formula:C28H16Cl2N4O2 Molecular Weight: 511.36 CAS Registry Number:12226-90-3
The title compound, C26H22N2O, was readily synthesized from the reaction between 8-amino-quinoline and 9-anthr-aldehyde in EtOH solution. There is an intramolecular N-H…N hydrogen bond and weak C-H…N/O interactions. The mol-ecule self-assembles into a zigzag chain along the c axis through - interactions ...
自然形成的氙共由7種穩定同位素組成,在各元素中排第二位。第一位是錫,其穩定同位素共有10個。穩定同位素數量高於7個的元素只有錫。[69]同位素134Xe根據預測能夠進行雙重β衰變,但這未經實驗證明,因此该同位素仍被認為是穩定的。[70]除這些穩定同位素之外,氙還有40多種不穩定同位素。其中壽命最長的為124Xe,它會進行双电子俘获衰變,半衰期為1.8×1022年。[6] 129I在β衰變後,會產生129Xe同位素。該反應的半衰期為1600萬年。另外131mXe、133Xe、133mXe和135Xe都是235U和239Pu的核裂變產物,[68]因此被用作探測核爆炸的發生。[71] ...
Electron transfer reactions have been studied between 9-anthracenecarboxylic acid co-adsorbed with perylene on silica gel surfaces employing azulene as a molecular shuttle in order to facilitate hole transfer. In this paper we present for the first time a ternary system that unambiguously demonstrates an appreciable mobility of radical cations on the silica gel surface. Rates of hole transfer from the 9-anthracenecarboxylic acid radical cation to perylene via azulene have been studied using diffuse reflectance laser flash photolysis spectroscopy. Azulene has been shown to enhance the rate of electron transfer in the ternary system, proving significant mobility of the azulene and its radical cation species on silica gel surfaces. The data shows that the azulene radical cation can diffuse at an appreciable rate on the silica gel surface ...
In this work, magnetic functionality was introduced to cross-linked acrylamide-based particles via the in situ coprecipitation of iron oxide nanoparticles within the hydrogel particle interior. Cibacron Blue F3G-A was then incorporated onto the magnetic hydrogel scaffold to facilitate the harvest of targeted protein species. The dye-loaded magnetic particles were physically characterized, and their protein sequestration performance was investigated. The results of these studies indicated that dye-loaded magnetic particles sequestered a greater amount of lower molecular weight proteins from the test solution than was achieved using reference particles, dye-loaded cross-linked N-isopropylacrylamide-based core-shell particles. This difference in protein harvesting ability may reflect the higher degree of dye-loading in the magnetic particles relative to the dye-loaded core-shell particles.
Dibenz(a,h)anthracene has produced tumours by different routes of administration in mice, rats, guinea pigs, frogs, pigeons and chickens. It has both local and systemic carcinogenic effects.. On oral administration, it produced tumours of the forestomach in the mouse; intratracheal administration to rats produced lung tumours. In repeated skin painting experiments in mice, dibenz(a,h)anthracene and benzo(a)pyrene appeared to be equally effective. In a dose-response study on s.c. carcinogenicity with dibenz(a,h)anthracene, benzo(a)pyrene and 3-methylcholanthrene, dibenz(a,h)anthracene was shown to be effective at a lower dose than that effective for benzo(a)pyrene or for 3-methylcholanthrene; its latent period, however, was longer. Dibenz(a,h)anthracene induced local sarcomas and increased the incidence of lung adenomas following a single s.c. injection in newborn mice at dose levels which were ineffective with 3-methylcholanthrene. It has not been adequately tested in other species. ...
Dibenz[a,h]anthracene has been shown to be carcinogenic to experimental animals.. Dibenz[a,h]anthracene is embryotoxic to rats when given at high doses. The available data on teratogenicity were inadequate for evaluation. Dibenz[a,h]anthracene was positive in differential survival assays using DNA-repair-proficient/-deficient strains of bacteria and was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. In cultured mammalian cells, dibenz[a,h]anthracene was mutagenic and induced unscheduled DNA synthesis in the presence of an exogenous metabolic system. It was positive in assays for morphological transformation. In the one available study, it induced sister chromatid exchange but not chromosomal aberrations in vivo.. There is sufficient evidence that dibenz[a,h]anthracene is active in short-term tests. ...
Aceptado junio 2009. ABSTRACT. The aim of this study was to determine the effect of linear alkylbenzene sulfonate (LAS), anthracene and a LAS anthracene mixture on the growth of a microbial consortium isolated from polluted sediment. The microbial consortium was grown in a sterile glass bottle with mineral medium containing 1 g/L of glucose. Microbial growth inhibition produced by LAS, anthracene and combinations of LAS and anthracene was determined by viable count in nutritive agar; inhibitory concentration 50 (IC50) was calculated. The concentrations evaluated were 0.16, 0.8, 1.6, 16 and 160 mg/L of LAS or anthracene. The LAS anthracene mixtures were prepared by fixing either LAS or anthracene at 0.16 mg/L while increasing the other compound at the above concentrations. Microbial growth was sensitive to LAS at an IC50 of 8.22 and to anthracene at an IC50 of 5.2 mg/L. In the LAS anthracene combination, if LAS concentration was fixed and anthracene concentration varied, IC50 (5.92 mg/L) was ...
Dibenz[a,h]anthracene; Dibenzo[a,h]anthracene; DBA; 1,2:5,6-Benzanthracene; 1,2:5,6-Dibenzanthracene; 1,2:5,6-Dibenzoanthracene; Db(a,h)a; Dibenz(a,h)antracene; 1,2,5,6-Dibenzanthraceen; 1,2:5,6-Dibenz(a)anthracene; 1,2,5,6-Dba; Rcra waste number U063; Dibenzo(a,h)anthracène; 1,2,5,6-Dibenzanthracene; NSC ...
Before starting maprotiline, be sure to let your doctor know if youve recently had a heart attack. This eMedTV page offers other important precautions and warnings with maprotiline, including possible side effects that may occur.
When medications like MAOIs or pressors are taken together with maprotiline, drug interactions may occur. This eMedTV page lists other medicines that may cause drug interactions with maprotiline and explains the risks involved with mixing medications.
The addition of both MEK1 inhibitor U0126 or JNK inhibitor SP600125 coupled with RI inhibitor SB431542 had no detectable result to the mesenchymal phenotype on the cells. The mixture these details of p38 MAPK inhibitor SB203580 and ROCK inhibitor Y27632 restored cortical actin stain ing, but tension fiber actin remained inside the cells. Escalating the concentration of RI inhibitor SB431542 to ten M led to a even more lessen from the level of anxiety fib ers, nonetheless, the combination of RI inhibitor SB431542 by using a p38 MAPK inhibitor SB203580 or ROCK inhibitor Y27632 was additional effective at getting rid of them. Related results were observed in wild variety mTEC cells, which has a mixture of RI inhibi tor SB431542 and ROCK inhibitor Y27632 reversing EMT as indicated by each gene expression and cell morphology. Collectively, these information indicate that therapy in the cells with RI inhibitor SB431542 by itself are unable to result in total re acqui selleck AZD4547 sition of cortical ...
Alfa Chemistry is the worlds leading provider for special chemicals. We offer qualified products for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-),please inquire us for 1594-08-7(9,10-Anthracenedione,1-hydroxy-4-[[4-[(methylsulfonyl)oxy]phenyl]amino]-).
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Transformation of Functional Groups . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . 80 81 81 87 90 92 93 93 95 95 97 98 98 99 100 101 101 101 101 102 102 103 105 106 112 113 114 115 116 116 118 121 122 124 124 124 125 125 126 128 130 132 132 133 133 133 134 Sec. A] 29 PYRAZOL-3-ONES. PART III I. Introduction The present article is Part III of a three part series. In Part I (01AHC(80)73) the synthesis and applications of pyrazol-3-ones I and II are described. G. Of Acyl or Imine Substituted Pyrazol-3-ones . . . . . . . . . . . H. With 1-(3-oxopyrazol-4-yl)-3-substituted Thioureas . . . . . . . . . X. Solvolysis . . . . . . . . . . . . . . . . . . . . . . . . . A. Of Carbonyl and Arylsulfonylpyrazol-3-ones . . . . . . . . . . . B. Of 4-(iminophenylmethyl or phenylaminomethylene)pyrazol-3-ones . . . C. Of (5-oxopyrazol-3-yl)acetamide or 4,4-(dimorpholin-4-yl)pyrazol-3-one . A. With Molecular Oxygen . . . . . . . . . . . . . . . . . . . B. With Bromine or ...
2-(2-Methylpropyl)-N-(thietan-3-yl)pyrazol-3-amine | C10H17N3S | CID 130891501 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Here is another molecule of the year, on a topic close to my heart, the catenane systems 1 and the trefoil knot 2 Such topology is closely inter-twinned with
SALT LAKE CITY, UT--(Marketwired - Oct 6, 2016) - Amedica Corporation (NASDAQ: AMDA), a biomaterial company that develops and commercializes silicon...
The simplest of such chemicals are naphthalene, having two aromatic rings, and the three-ring compounds anthracene and ... In some PAHs, like naphthalene, anthracene, and coronene, all carbon and hydrogen atoms lie on the same plane. This geometry is ... while anthracene is at 374 nm.[20] Three Clar structures with two sextets each are present in the four-ring chrysene structure ... anthracene, a PAH that was subsequently demonstrated to cause tumors.[74] Cook, Hewett and Hieger then linked the specific ...
Part 1.-Anthracene". Trans. Faraday Soc. 63 (0): 1720-1729. doi:10.1039/TF9676301720. ISSN 0014-7672. Gupta, K. M. (2015). ...
I. Via anthracene adducts". Polym. Sci., Polym. Chem. Ed. 16 (10): 2475-2507. Bibcode:1978JPoSA..16.2475B. doi:10.1002/pol. ... anthracene > butadiene Dienophile: N2 > CO2 > naphthalene > benzene, nitriles > methacrylate > maleimides > cyclopentadiene, ...
The oxidation of anthracene, a reaction that is localized at the central ring. Chromium(VI) is the typical oxidant. ...
1-Chloro-9,10-bis(phenylethynyl)anthracene Orange 5,12-Bis(phenylethynyl)naphthacene, Rubrene, Rhodamine 6G ...
... who published models of naphthalene and anthracene in 1921 based on other molecules, an early form of molecular replacement.[47 ... "The crystalline structure of anthracene". Proc. R. Soc. Lond. 35 (1): 167. Bibcode:1922PPSL...35..167B. doi:10.1088/1478-7814/ ...
Similarly, anthracene is formylated at the 9-position. The reaction of anthracene with N-methylformanilide, also using ... "Formylation of anthracene". 20: 11. doi:10.15227/orgsyn.020.0011. Cite journal requires ,journal= (help) Jones, G.; Stanforth, ...
... anthracene, and phenanthrene. In fused aromatics, not all carbon-carbon bonds are necessarily equivalent, as the electrons are ...
Other PAC compounds appearing as minerals include fluorene as kratochvilite; and anthracene as ravatite. Others are mixtures: ...
"Anthracene, 1,9-dibromo-". pubchem.ncbi.nlm.nih.gov. "1,10-Dibromoanthracene". pubchem.ncbi.nlm.nih.gov. "2,3-Dibromoanthracene ... A dibromoanthracene is a derivative of anthracene with two bromine atoms. All compounds have the formula C14H8Br2. They can ...
The earliest example of a [4+4] photocycloaddition was the photodimerization of anthracene, discovered in 1936. This reaction ... 2+2] Photocycloaddition Cycloaddition Fieser, Louis F.; Lothrop, Warren C. (1936). "The Structure of Anthracene". J. Am. Chem. ... Other polycyclic aromatics undergo anthracene-like photocycloaddition, such as acridizinium salts. Biologically active natural ...
They found that a hole current can flow through an anthracene crystal contacted with a positively biased electrolyte containing ... Work on conductivity of anthracene crystals contacted with an electrolyte showed that optically excited dye molecules adsorbed ... Sano; Pope; Kallmann (1965). "Electroluminescence and Band Gap in Anthracene". J. Chem. Phys. 43 (8): 2920. Bibcode:1965JChPh.. ... Sano; Pope; Kallmann (1965). "Recombination Radiation in Anthracene Crystals". Physical Review Letters. 14 (7): 229-231. ...
... electroluminescence under vacuum on a single pure crystal of anthracene and on anthracene crystals doped with tetracene in 1963 ... Pope's group reported in 1965 that in the absence of an external electric field, the electroluminescence in anthracene crystals ... Their proposed mechanism involved electronic excitation at the contacts between the graphite particles and the anthracene ... Sano, Mizuka; Pope, Martin; Kallmann, Hartmut (1965). "Electroluminescence and Band Gap in Anthracene". The Journal of Chemical ...
Begley, M. J.; Puntambekar, S. G.; A. H., Wright (1987). "A di-iron-anthracene complex via ultrasonics". Chemical ...
Anthracene, Phenanthrene or Biphenyl)". Journal of Inclusion Phenomena and Macrocyclic Chemistry. 39 (1/2): 175-180. doi: ...
Anthracene was heavily studied due to its known crystal structure and its commercial availability in high-purity single ... A. M. Mathieson; J.M. Robertson; V.C. Sinclair (1950). "The crystal and molecular structure of anthracene. I. X-ray ... In the early 20th century, Pochettino and Volmer studied the first organic compound, anthracene, in which photoconductivity was ... G.J. Sloan (1966). "Studies on the Purification of Anthracene; Determination and Use of Segregation Coefficients". Mol. Cryst. ...
2-Chloro-9,10-bis(phenylethynyl)anthracene. ...
1- and 2-substituted anthracenes typically are prepared via the hydroxy anthroquinones, which means that the preparation of ... Anthrols are the hydroxylated derivatives of anthracene. For the monohydroxo derivatives, three isomers are possible: 1-anthrol ...
Michl, Joseph; Thulstrup, E. W. (1976). "Why is azulene blue and anthracene white? A simple mo picture". Tetrahedron. 32 (2): ...
This enzyme participates in naphthalene and anthracene degradation. This enzyme belongs to the family of lyases, specifically ...
"Charge Carrier Production and Mobility in Anthracene Crystals". Phys. Rev. 119 (4): 1226. Bibcode:1960PhRv..119.1226K. doi: ...
This enzyme participates in naphthalene and anthracene degradation. He Z, Nadeau LJ, Spain JC (2000). "Characterization of ...
It contains among other things anthracene and phenol. Because of its rot-resisting and disinfecting effect, Carbolineum was ...
This enzyme participates in naphthalene and anthracene degradation. Nagao K, Takizawa N, Kiyahara H (1988). "Purification and ...
This enzyme participates in naphthalene and anthracene degradation. (+)-Cavicularin, a cyclic bibenzyl-dihydrophenanthrene ...
This enzyme participates in naphthalene and anthracene degradation. It has 4 cofactors: FAD, Iron, Sulfur, and Iron-sulfur. ...
This enzyme participates in naphthalene and anthracene degradation. Eaton RW, Chapman PJ (1992). "Bacterial metabolism of ...
PMID 16511195 DOI: 10.1107/S1744309105028514 Agbandje M, Jenkins TC, McKenna R, Reszka AP, Neidle S. Anthracene-9,10-diones as ... M, Agbandje; Tc, Jenkins; R, McKenna; Ap, Reszka; S, Neidle (1992-04-17). "Anthracene-9,10-diones as Potential Anticancer ... During her PhD, she characterized the DNA binding characteristics of Anthracene-9,10-diones to explore their cytotoxic ...
This enzyme participates in naphthalene and anthracene degradation. It employs one cofactor, iron. This enzyme belongs to the ...
Stanford Research Institute (SRI International). R.G., Kepler (1960). "Charge Carrier Production and Mobility in Anthracene ...
All rights reserved. The published material is being distributed without warranty of any kind, either expressed or implied. Neither ILO nor WHO nor the European Commission shall be responsible for the interpretation and use of the information contained in this material ...
Other names: Anthracin; Green Oil; Paranaphthalene; Tetra Olive N2G; Anthracene oil; p-Naphthalene; Anthracen; Coal tar pitch ...
Anthracene is used in the production of the red dye alizarin and other dyes. Anthracene is colorless but exhibits a blue (400- ... Reduction of anthracene with alkali metals yields the deeply colored radical anion salts M+[anthracene]− (M = Li, Na, K). ... The anthracene tracer allows the conformal coating to be inspected under UV light. Anthracene also used in manufacturing of ... Anthracene is converted mainly to anthraquinone, a precursor to dyes. Anthracene, a wide band-gap organic semiconductor is used ...
Hydrogen induces release of anthracene, yielding magnesium hydride (MgH2). Borislav Bogdanovic (1988). "Magnesium Anthracene ... Magnesium anthracene is an organomagnesium compound that is almost invariably isolated as its adduct with three tetrahydrofuran ... anthracene)(THF)3] and [Mg(triphenylmethyl)Br(OEt2)2]". Journal of Organometallic Chemistry. 341 (1-3): 39. doi:10.1016/0022- ... and water-sensitive orange solid is obtained by heating a suspension of magnesium in a thf solution of anthracene. According to ...
Benz[a]anthracene or benzo[a]anthracene is a polycyclic aromatic hydrocarbon with the chemical formula C18H12. It is produced ... Benz[a]anthracene is one of carcinogenic constituents of tobacco smoke. Tetracene, also known as benz[b]anthracene "Front ... ISBN 978-0-85404-182-4. "Benzo[a]anthracene [MAK Value Documentation, 2012]". The MAK-Collection for Occupational Health and ...
Anthracene is an organic semiconductor.. Anthracene is used as a scintillator for detectors of high energy photons, electrons ... NIST Chemistry WebBook Anthracene. Credits. New World Encyclopedia writers and editors rewrote and completed the Wikipedia ... Anthracene is used in the artificial production of the red dye alizarin. It is also used in wood preservatives, insecticides, ... Anthracene has the ability to photodimerize with irradiation by UV light. This results in considerable changes in the physical ...
... anthracene. Find out what is in your tap water ... anthracene results for City of Beeville , Benzo[a] ... Benzo[a]anthracene. City of Beeville. Benzo[a]anthracene is a polycyclic aromatic hydrocarbon, or PAH, released from combustion ...
96 % of a crystalline/fine-granular batch of anthracene production comprised of particles with a diameter range of 0.1 to 2 mm ... The mass median diameter was determined as 0.75 mm in a fine-granular batch of solid anthracene (RÜTGERS 2010). ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
The title compound, C26H22N2O, was readily synthesized from the reaction between 8-amino-quinoline and 9-anthr-aldehyde in EtOH solution. There is an intramolecular N-H…N hydrogen bond and weak C-H…N/O interactions. The mol-ecule self-assembles into a zigzag chain along the c axis through - interactions ...
Anthracene oil EC Number:. 292-602-7. EC Name:. Anthracene oil. CAS Number:. 90640-80-5 Molecular formula:. Not applicabel ... AnthraceneAnthracene. CAS Number:. 120-12-7. Molecular formula:. C14H10. IUPAC Name:. ... AnthraceneAnthracene. CAS Number:. 120-12-7. Molecular formula:. C14H10. IUPAC Name:. ... AnthraceneAnthracene. CAS Number:. 120-12-7. Molecular formula:. C14H10. IUPAC Name:. ...
The Diels-Alder Reaction of Anthracene with Maleic Anhydride 1 The Diels-Alder Reaction of Anthracene with Maleic Anhydride ... The Diels-Alder Reaction of Anthracene with Maleic Anhydride 1 The Diels-Alder Reaction of Anthracene with Maleic Anhydride ... Anthracene was the diene and maleic anhydride was the dienophile. The percent yield of the crude product was 69.03%. Following ... More about The Diels-Alder Reaction of Anthracene with Maleic Anhydride. * Reactions And Reactions Of Redox Reactions. 2214 ...
Cowan D.O., Drisko R.L. (1976) Photochemical Techniques and the Photodimerization of Anthracene and Related Compounds. In: ... In answering these questions we will be concerned mainly with the photochemistry of anthracene and related compounds. ...
9,10-(Divinyl) Anthracene Based Bright Aggregation-Induced Emission Organic Dots for HeLa Cells Imaging ... By encapsulating AIE molecule 9,10-divinyl anthracene (DSA) with poly(styrene-co-maleic anhydride) and poly(isobutylene-alt- ...
... anthracene-1-sulfonic acid
An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous ... Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles Y. Shi, R. M. Cardoso, C. F. van Nostrum and ... An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous ...
DIBENZ[a,h]ANTHRACENE. VOL.: 32 (1983) (p. 299) CAS No.: 53-70-3. Chem. Abstr. Name: Dibenz(a,h)anthracene. 5. Summary of Data ... There is sufficient evidence that dibenz[a,h]anthracene is active in short-term tests. 5.2 Human data. Dibenz[a,h]anthracene is ... Dibenz[a,h]anthracene has been shown to be carcinogenic to experimental animals.. Dibenz[a,h]anthracene is embryotoxic to rats ... 1,2:5,6-Dibenz(a)anthracene * 1,2,7,8-Dibenzanthracene * 1,2:5,6-Dibenzoanthracene * Dibenzo[a,h]anthracene Last updated: 17 ...
DIBENZ(a,h)ANTHRACENE. VOL.: 3 (1973) (p. 178) 5. Summary of Data Reported and Evaluation. 5.1 Animal carcinogenicity data. ... In a dose-response study on s.c. carcinogenicity with dibenz(a,h)anthracene, benzo(a)pyrene and 3-methylcholanthrene, dibenz(a, ... In repeated skin painting experiments in mice, dibenz(a,h)anthracene and benzo(a)pyrene appeared to be equally effective. ... Dibenz(a,h)anthracene induced local sarcomas and increased the incidence of lung adenomas following a single s.c. injection in ...
7,12-Dimethylbenz a) anthracene breast cancer: hormonal influences on tumour initiation and promotion Lead researcher. A G ...
Hydrogen transfer to multiple bonds by dissociation of the diimide-anthracene adduct, anthracene-9,10-biimine. J Am Chem Soc 84 ... A single-step fragmentation with concerted loss of singlet SO and N2 from the anthracene platform was found, featuring a single ... 2012) Facile synthesis of Dibenzo-7λ3-phosphanorbornadiene derivatives using magnesium anthracene. J Am Chem Soc 134:13978- ... Selection of previously reported compounds capable of SO transfer (A-E) and the anthracene-based sulfinylhydrazine 1 described ...
ANTHRACENE (purity) from LGC Standards. Please login or register to view prices, check availability and place orders. ... 1-METHYLBENZ (a) ANTHRACENE (purity). 10 mg. BCR-093R. Add to basket ...
Identification and quantitation of 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse skin.. Devanesan PD1, RamaKrishna ... Identification and quantitation of the depurination and stable DNA adducts of 7,12-dimethylbenz[a]anthracene (DMBA) formed by ... anthracene (MBA)-12-CH2-N7Ade and 7-MBA-12-CH2-N7Gua. The depurination adducts were identified by HPLC and fluorescence line ...
... accessment of anthracene in sediment (unsieved) at station Clyde_FirthCInnerDunoon_se06, Holy Loch (Clyde) from the Marine ... CSEMP assessment of anthracene in sediment at Holy Loch (Clyde). Statistical analysis. Trend assessment. Analysis of variance. ... Determinand : Anthracene. Units : μg kg-1 dry weight normalised to 2.5% organic carbon. Data extraction : 27 June 2019. ...
... accessment of anthracene in sediment (unsieved) at station Clyde_(Hunterston)_seSF, Hunterston (Clyde) from the Marine ... Determinand : Anthracene. Units : μg kg-1 dry weight normalised to 2.5% organic carbon. Data extraction : 30 April 2020. ... CSEMP assessment of anthracene in sediment at Hunterston (Clyde). Statistical analysis. Trend assessment. Analysis of variance ...
... anthracene-12-methanol, 2-fluoro-7-methyl- , C20H15FO , CID 186993 - structure, chemical names, physical and chemical ...
Browse by Exposure: anthracene (5 articles). % of records by year: 1965 2017 ...
9-bromo-10-naphthalen-1-yl anthracene, 9-bromo-10-1-naphthalenyl anthracene, 9-bromo-10-1-naphthyl anthracene, anthracene, 9- ... 9-bromo-10-naphthalen-1-yl anthracene, 9-bromo-10-1-naphthalenyl anthracene, 9-bromo-10-1-naphthyl anthracene, anthracene, 9- ... 9-bromo-10-naphthalen-1-yl-anthracene, 10-bromo-9-phthalen-1-yl anthracene, 10-bromo-9-naphthalen-1-yl anthracene, 9-bromo-10-1 ... 9-bromo-10-naphthalen-1-yl-anthracene, 10-bromo-9-phthalen-1-yl anthracene, 10-bromo-9-naphthalen-1-yl anthracene, 9-bromo-10-1 ...
... Oncogene. 1999 Nov 11;18 ... anthracene (DMBA). Surprisingly, the nontransgenic mice developed mammary tumors with decreased latency. Tumors arising in WAP- ...
"Anthracenes" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Anthracenes" by people in this website by year, and whether " ... Below are the most recent publications written about "Anthracenes" by people in Profiles. ...
  • Identification and quantitation of the depurination and stable DNA adducts of 7,12-dimethylbenz[a]anthracene (DMBA) formed by cytochrome P450 in rat liver microsomes previously established one-electron oxidation as the predominant mechanism of activation of DMBA to bind to DNA. (nih.gov)
  • The depurination adducts, which constitute 99% of all the adducts detected, are DMBA bound at the 12-methyl group to the N-7 of adenine or guanine, namely, 7-methylbenz[a]anthracene (MBA)-12-CH2-N7Ade and 7-MBA-12-CH2-N7Gua. (nih.gov)
  • Overexpression of Bcl-2 in the mammary gland using a whey acidic protein (WAP) promoter-driven Bcl-2 transgene inhibits apoptosis in the mammary gland during pregnancy, lactation, and involution, and also counteracts apoptosis induced by overexpression of a mutant p53 transgene (WAP-p53 172 R-L). WAP-Bcl-2 mice and nontransgenic controls were treated with the carcinogen dimethylbenz(a)anthracene (DMBA). (nih.gov)
  • Because NF-κB suppression has been linked with chemoprevention, this prompted us to investigate the chemopreventive potential of resveratrol by testing it against mammary carcinogenesis induced by 7,12-dimethylbenz( a )anthracene (DMBA) in female Sprague Dawley rats. (aacrjournals.org)
  • We explored the basis of the combinatorial chemopreventive effect of Butyric acid (BA), Nicotinamide (NA) and Calcium Glucarate (CAG) on mouse skin exposed to 7, 12-dimethylbenz (a) anthracene (DMBA). (biomedsearch.com)
  • Treatment with 2.56 micrograms (10 nmol) 7,12-dimethylbenz[a] anthracene (DMBA) resulted in maximal MN induction in cells removed from skin 12-24 hr after topical administration (79-88 MN/1,000 cells compared with 10-16 MN/1,000 cells in acetone-treated controls). (biomedsearch.com)
  • 7,12-DMBA was almost two orders of magnitude more active as a tumor -initiator than 7- and 12-methylbenz[a] anthracene . (curehunter.com)
  • Immunohistochemistry and autoradiography were used to identify sites of the cytochrome P450 enzymes (P450) 1A1 and 1B1 expression and activation of 7,12-dimethylbenz(a)anthracene (DMBA), in the brain of rodents pretreated with the aryl hydrocarbon receptor (AhR) agonists beta-naphthoflavone (BNF), 3,3',4,4',5-pentachlorobiphenyl or vehicle. (diva-portal.org)
  • Aim of the present study was to evaluate the anti-tumor effect of orally administered rosmarinic acid in 7,12-dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. (niscair.res.in)
  • Our aim of this study was to examine the chemopreventive potential of fish oil on 7, 12-Dimethylbenz (a) Anthracene (DMBA)-initiated and croton oil-promoted skin papillomagenesis model in mice. (alliedacademies.org)
  • 7,12-Dimethylbenz[a]anthracene (DMBA) depletes ovarian follicles and induces DNA damage in extra-ovarian tissues, thus, we investigated ovarian DMBA-induced DNA damage. (ovid.com)
  • Mammary tumours were induced in female Sprague-Dawley rats by feeding orally with dimethylbenz [a]anthracene (DMBA) (60 mg/kg). (biomedcentral.com)
  • Benz[a]anthracene or benzo[a]anthracene is a polycyclic aromatic hydrocarbon with the chemical formula C18H12. (wikipedia.org)
  • Benzo[a]anthracene is a polycyclic aromatic hydrocarbon, or PAH, released from combustion of fossil fuels and waste incinerators. (ewg.org)
  • In repeated skin painting experiments in mice, dibenz( a , h )anthracene and benzo( a )pyrene appeared to be equally effective. (inchem.org)
  • Micronuclei in mouse skin cells following in vivo exposure to benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene, chrysene, pyrene and urethane. (biomedsearch.com)
  • The metabolism of two carcinogenic polynuclear aro matic hydrocarbons, benzo[a]pyrene (BP) and 7,12-dimethylbenz[a]anthracene, was studied in expiants of human pancreatic duct and bronchus cultured in a chemically defined medium. (au.dk)
  • Benz[a]anthracene is one of carcinogenic constituents of tobacco smoke. (wikipedia.org)
  • Mouse skin tumor-initiating activity of 5-, 7-, and 12-methyl- and fluorine-substituted benz[a]anthracenes. (curehunter.com)
  • Methyl substitution at the 7- and 7,12-positions of benz[a]anthracene was significantly more effective in the enhancement of tumorigenic activity than fluorine substitution at these positions. (curehunter.com)
  • In cultured human bronchial mucosa, activity of aryl hydrocarbon hydroxylase was inducible by both benz[a]anthracene and BP. (au.dk)
  • Prior exposure of the bronchial expiants to benz[a]anthracene altered the qualitative features of the metabolite profile of BP as analyzed by highpressure liquid chromatography. (au.dk)
  • Dibenz[ a,h ]anthracene has been shown to be carcinogenic to experimental animals. (inchem.org)
  • Dibenz[ a,h ]anthracene is embryotoxic to rats when given at high doses. (inchem.org)
  • Dibenz[ a,h ]anthracene was positive in differential survival assays using DNA-repair-proficient/-deficient strains of bacteria and was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. (inchem.org)
  • In cultured mammalian cells, dibenz[ a,h ]anthracene was mutagenic and induced unscheduled DNA synthesis in the presence of an exogenous metabolic system. (inchem.org)
  • There is sufficient evidence that dibenz[ a,h ]anthracene is active in short-term tests. (inchem.org)
  • Dibenz[ a,h ]anthracene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. (inchem.org)
  • Human exposure to dibenz[ a,h ]anthracene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated with combustion products. (inchem.org)
  • There is sufficient evidence that dibenz[ a,h ]anthracene is carcinogenic to experimental animals. (inchem.org)
  • Dibenz( a , h )anthracene has produced tumours by different routes of administration in mice, rats, guinea pigs, frogs, pigeons and chickens. (inchem.org)
  • Dibenz( a , h )anthracene induced local sarcomas and increased the incidence of lung adenomas following a single s.c. injection in newborn mice at dose levels which were ineffective with 3-methylcholanthrene. (inchem.org)
  • No case reports or epidemiological studies on the significance of dibenz( a , h )anthracene exposure to man are available. (inchem.org)
  • However, coal-tar and other materials which are known to be carcinogenic to man may contain dibenz( a , h )anthracene. (inchem.org)
  • A classic laboratory method for the preparation of anthracene is by cyclodehydration of o-methyl- or o-methylene-substituted diarylketones in the so-called Elbs reaction. (wikipedia.org)
  • Anthracene also reacts with dienophile singlet oxygen in a [4+2]-cycloaddition (Diels-Alder reaction): Chemical oxidation occurs readily, giving anthraquinone, C14H8O2 (below), for example using hydrogen peroxide and vanadyl acetylacetonate. (wikipedia.org)
  • This experiment involved a reaction between anthracene and maleic anhydride via a Diels Alder reaction to yield 9, 10-dihydroanthracene-9,10-α, β-succinic anhydride. (bartleby.com)
  • The purpose of this experiment is to form 9,10-dihydroanthracene-9,10-α,β-succinic anhydride by way of a Diels Alder reaction between anthracene and maleic anhydride, as shown in the reaction below. (vernier.com)
  • The structure of newly formed fullerene/anthracene cluster cations and the bonding energy for these reaction pathways are investigated with quantum chemistry calculations. (arxiv.org)
  • The synthesis involved a Diels-Alder reaction of anthracene and dimethyl fumarate to afford 3 followed by reduction, oxidation and esterification reactions to provide methyl ester anthracene adduct 8, which further converted to the the allylic alcohol (12). (edu.au)
  • Then, Ring-Closing Metathesis (RCM) reaction afforded the cyclopentenol anthracene adduct, which after oxidation provided the spirocyclopente-dione anthracene adduct in good yields. (edu.au)
  • The nature of reaction conditions influenced the extent of anthracene degradation. (bibsys.no)
  • 1.1,8,9-Tris (phenylseleno) anthracene (1) has been tried to prepare in the reaction of 1,8-bis (phenylseleno) anthracene (2) with various organometallic reagents. (nii.ac.jp)
  • Zuschriften Expanded Porphyrins Anthracene-Bridged Z-Shaped [26]Hexaphyrin(1.1.1.1.1.1.1) Dimer from the Regioselective Diels-Alder Reaction of a Hexaphyrin with Bis-o-xylylene Equivalents Hiroshi Hata, Hiroshi Shinokubo,* and Atsuhiro Osuka* Expanded porphyrins which are porphyrin analogues with more than five pyrrolic subunits have recently attracted much attention because of their interesting structural and functional features and unique metal-coordination properties. (docme.ru)
  • A complex combination of polycyclic aromatic hydrocarbons obtained from coal tar having an approximate distillation range of 300°C to 400°C (572°F to 752°F). Composed primarily of phenanthrene, anthracene and carbazole. (europa.eu)
  • Anthracene was the diene and maleic anhydride was the dienophile. (bartleby.com)
  • Anthracene acts as the diene and maleic anhydride functions as the dienophile. (vernier.com)
  • Substituted anthracene derivatives behave similarly. (wikipedia.org)
  • A variety of anthracene derivatives find specialized uses. (wikipedia.org)
  • The reversible bonding and photochromic properties of anthracenes are the basis of many potential applications using poly and monosubstituted anthracene derivatives. (newworldencyclopedia.org)
  • and multiple hydro-anthracene derivatives from reductive hydogenation. (bibsys.no)
  • Anthracene is converted mainly to anthraquinone, a precursor to dyes. (wikipedia.org)
  • We report here on the synthesis and reactivity of a precursor molecule that readily fragments with concomitant expulsion of dinitrogen and anthracene to release the highly reactive sulfur monoxide, a compound of interest for both synthetic chemists and astrochemists. (pnas.org)
  • Synthesis of spirocyclopente-dione anthracene adduct, precursor of the" by Gedsirin Eksinitkun, Stephen G. Pyne et al. (edu.au)
  • A synthesis of the spirocyclopente-dione anthracene adduct, a precursor of the cyclopentenone prostaglandins has been reported. (edu.au)
  • A pioneering approach to in situ damage precursor detection in fiber reinforced polymer composites is developed using anthracene-based stress-sensitive mechanophore material. (elsevier.com)
  • Premalignant lesions and mammary carcinomas were induced by medroxyprogesterone acetate and 7,12-dimethylbenz[a]anthracene treatment. (nih.gov)
  • Whey Protein Hydrolysate but not Whole Whey Protein Protects Against 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats. (nih.gov)
  • Experiments were done to study the effect of 7,12-dimethylbenz(a)anthracene on the incorporation of thymidine-methyl- 3 H (thymidine- 3 H) into mammary gland DNA of female and male rats in vitro and in vivo and on DNA polymerase activity of mammary gland tissue. (aacrjournals.org)
  • At age 50 days, F 1 (experiment A) or F 2 (experiment B) female offspring (≥19 rats/group) were p.o. gavaged with 80 mg/kg 7,12-dimethylbenz( a )anthracene, and mammary glands were evaluated when 100% of the casein-fed group developed at least one palpatable tumor. (aacrjournals.org)
  • Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis by retinyl acetate. (semanticscholar.org)
  • The administration of 2.5 mg retinyl acetate daily in the diet to female Sprague-Dawley rats beginning 7 days after the intragastric instillation of either 2.5, 5, or 15 mg 7,12-dimethylbenz(a)anthracene (CMBA) resulted in a reduction in the incidence of benign mammary tumors of 37, 30, and 31%, respectively. (semanticscholar.org)
  • Smet M, Corens D, Van Meervelt L, Dehaen W. Synthesis of the Formal Diels-Alder Adducts of N-substituted Dehydromaleimides and Anthracene. (mdpi.com)
  • Anthracene is a solid polycyclic aromatic hydrocarbon (PAH) of formula C14H10, consisting of three fused benzene rings. (wikipedia.org)
  • In chemistry, anthracene is a solid polycyclic aromatic hydrocarbon consisting of three benzene rings derived from coal-tar. (newworldencyclopedia.org)
  • Anthracene, a wide band-gap organic semiconductor is used as a scintillator for detectors of high energy photons, electrons and alpha particles. (wikipedia.org)
  • Anthracene is an organic semiconductor. (newworldencyclopedia.org)
  • Detection of gases using an organic semiconductor, anthracene. (elsevier.com)
  • This detector called the organic semiconductor detector (OSD) makes use of the surface cell of anthracene single crystal. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Detection of gases using an organic semiconductor, anthracene. (elsevier.com)
  • Short-chain glucose polymer and anthracene-9-carboxylic acid inhibit water and electrolyte secretion induced by dibutyryl cyclic AMP in the small intestine. (ceraproductsinc.com)
  • Dimeric 9-anthracene carboxylic acid (Di-AC) is synthesized and incorporated into glass fiber reinforced polymer (GFRP) composites through a hand layup process. (elsevier.com)
  • Anthracene also used in manufacturing of anthraquinone. (wikipedia.org)
  • Electrophilic substitution occurs at the "9" and "10" positions of the center ring, and oxidation of anthracene occurs readily, giving anthraquinone, C 14 H 8 O 2 (below). (newworldencyclopedia.org)
  • Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields. (emf-portal.org)
  • The K-region trans-5,6-dihydrodiols formed in the metabolism of 12-methylbenz[a]anthracene (12-MBA) by liver microsomal preparations from untreated, phenobarbital-treated and 3-methylcholanthrene-treated male Sprague-Dawley rats were found by chiral stationary-phase h.p.l.c. (c.s.p.-h.p.l.c.) analyses to contain (5S,6S)/(5R,6R) enantiomer ratios of 93:7, 88:12 and 97:3 respectively. (biochemj.org)
  • Anthracene, as many other polycyclic aromatic hydrocarbons, is generated during combustion processes. (wikipedia.org)
  • Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events. (biomedsearch.com)
  • Effect of radiofrequency radiation exposure on mouse skin tumorigenesis initiated by 7,12-dimethybenz[alpha]anthracene. (emf-portal.org)
  • With the formula Mg(C14H10)(thf)3, this air- and water-sensitive orange solid is obtained by heating a suspension of magnesium in a thf solution of anthracene. (wikipedia.org)
  • In this work, we study the formation and photo-dissociation processes of astronomically relevant fullerene/anthracene (C14H10) cluster cations in the gas phase. (arxiv.org)
  • C14H10)nC60]+ and [(C14H10)nC70]+), fullerene (C56 and C58)/anthracene (i.e. (arxiv.org)
  • C14H10)nC56]+ and [(C14H10)nC58]+) and fullerene (C66 and C68)/anthracene (i.e. (arxiv.org)
  • Doubly boron-doped anthracenes and pentacenes have been longitudinally and laterally expanded through annulation of thiophene or benzene rings. (rsc.org)
  • The boiling point of pure benzene is 80.10 °d whereas the solution has a boiling point of 80.34 °C. What is the molecular formula of anthracene? (bartleby.com)
  • Anthracene is a tricyclic aromatic hydrocarbon derived from coal tar which is insoluble in water but is soluble in most organic solvents such as carbon disulphide, alcohols, benzene, chloroform, and hydronaphthalenes. (industryarc.com)
  • Coal tar, which contains around 1.5% anthracene, remains a major source of this material. (wikipedia.org)
  • The mineral form of anthracene is called freitalite and is related to a coal deposit. (wikipedia.org)
  • Residues (coal tar), anthracene oil distn. (zanran.com)
  • Magnesium anthracene is an organomagnesium compound that is almost invariably isolated as its adduct with three tetrahydrofuran (thf) ligands. (wikipedia.org)
  • Hydrous pyrolysis is explored as a technique for the treatment of industrial water containing PAH, using anthracene as a model compound. (bibsys.no)
  • 6. The anthracene-based compound as claimed in claim 1, wherein: n is an integer of 1 to 3, and a moiety represented by (L) n is selected from Formulae 3-1 to 3-9, below: ##STR00114## ##STR00115## in Formulae 3-1 to 3-9 above, ** is a binding site to an anthracene core, and * is a binding site to Ar. (patentsencyclopedia.com)
  • It reverts to anthracene thermally or with UV irradiation below 300 nm. (wikipedia.org)
  • Anthracene has the ability to photodimerize with irradiation by UV light. (newworldencyclopedia.org)
  • With irradiation, all the fullerene/anthracene cluster cations dissociate into mono$-$anthracene and fullerene species without dehydrogenation. (arxiv.org)
  • Identification and quantitation of 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse skin. (nih.gov)
  • CYP1A1 and CYP1B1 in blood-brain interfaces : CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells. (diva-portal.org)
  • 7,12-Dimethylbenz[a]anthracene was bound to the DMA of cultured human bronchial cells at higher levels than was BP. (au.dk)
  • Binding of 7,12-dimethylbenz[a]anthracene to DMA in human pancreatic duct was consistently less than that in cultured bronchi in the 5 patients studied. (au.dk)
  • Reduction of anthracene with alkali metals yields the deeply colored radical anion salts M+[anthracene]− (M = Li, Na, K). Hydrogenation gives 9,10-dihydroanthracene, preserving the aromaticity of the two flanking rings. (wikipedia.org)
  • Their catalytic performance for anthracene hydrogenation was evaluated using a slurry-bed batch reactor with an initial hydrogen pressure of 80 bar at 350 °C for 4 h. (springer.com)
  • The MoS 2 nanoflowers have high catalytic activities for anthracene hydrogenation. (springer.com)
  • Anthracene can also have a hydroxyl group to form 1-hydroxyanthracene and 2-hydroxyanthracene, homologous to phenol and napthol, and hydroxyanthracene is also called anthrol, and anthracenol. (newworldencyclopedia.org)
  • Anthracene photodimerizes by the action of UV light: The dimer, called dianthracene (or sometimes paranthracene), is connected by a pair of new carbon-carbon bonds, the result of the [4+4] cycloaddition. (wikipedia.org)
  • Electrophilic substitution of anthracene occurs at the 9 position. (wikipedia.org)
  • By encapsulating AIE molecule 9,10-divinyl anthracene (DSA) with poly(styrene-co-maleic anhydride) and poly(isobutylene-alt-maleic anhydride) (PSMA and PIMA), novel bright AIE organic dots were obtained. (ingentaconnect.com)
  • Their magnitudes were close to values predicted for an ellipsoid of shape and size equivalent to an anthracene molecule, and exhibited predictable variation with external conditions-increasing with temperature and decreasing with solventviscosity. (ku.edu)
  • ANTHRACENE OIL (CAS 65996-91-0) Market Research Report 2018 aims at providing comprehensive data on anthracene oil market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • Globally North America dominated the market for anthracene in 2015 due higher consumption and high R&D activities in the region related to anthracene and its applications. (industryarc.com)
  • This is report has been further segmented into major regions, which includes detailed analysis of each region such as North America, Europe, Asia-Pacific (APAC) and Rest of the World (RoW) covering all the major country level markets for anthracene in each of the region. (industryarc.com)
  • Based on experimental data, anthracene shows acute toxicity within the range of its water solubility (~40 - 70 µg/L). Aquatic toxicity is most pronounced in fish, daphnia and algae in the presence of UV-A light. (europa.eu)
  • Hydrogen induces release of anthracene, yielding magnesium hydride (MgH2). (wikipedia.org)
  • The reactivity of anthracene under a range of temperatures and durations are studied in this paper. (bibsys.no)
  • Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite, Plasmodium falciparum, with IC50 values in the nM-μM range. (up.ac.za)
  • Table 8: Log KOW and log KOC data of the relevant constituents present in anthracene oil, anthracene paste, distn. (zanran.com)
  • Asia-Pacific is expected to continue its domination and is also expected to be fastest growing market for the anthracene during the period of study due to increasing demand for anthracene in various end-use industries such as textiles and chemicals in major countries such as China, India and many others. (industryarc.com)
  • Anthracene is used in the production of the red dye alizarin and other dyes. (wikipedia.org)
  • Rising demand for anthracene in textiles industry due to growing production of textiles dyes is expected to be the key driver during the period of study. (industryarc.com)
  • 2.2 Volatilisation For the substance anthracene oil , anthracene paste, distn. (zanran.com)
  • In most other reactions of anthracene, the central ring is also targeted, as it is the most highly reactive. (newworldencyclopedia.org)
  • In answering these questions we will be concerned mainly with the photochemistry of anthracene and related compounds. (springer.com)
  • Aliquots of 1.0-10.0mg of anthracene in a range of 1.0-5.0 mL of H(2)O are subjected to hydrous pyrolysis under varied conditions of temperature, reagents and duration. (bibsys.no)
  • Anthracene is to also be used as a diluent for wood protection products, an insecticide, or a fungicide and as an organic crystallized photoconductor used in electrophotography. (industryarc.com)
  • The products formed are more reactive (less stable) as compared to anthracene the starting material and will therefore be less persistent in the environment. (bibsys.no)