Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Infections by nematodes, general or unspecified.
A genus of parasitic nematode worms which infest the duodenum and stomach of domestic and wild herbivores, which ingest it with the grasses (POACEAE) they eat. Infestation of man is accidental.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Antinematodal benzimidazole used in veterinary medicine.
A superfamily of strongyles or roundworms which are parasites in the intestinal tract of equines, pigs, rodents, and primates (including man). It includes the genera Cyasthostomum, Ransomus, Globocephalus, OESOPHAGOSTOMUM, and STRONGYLUS.
Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.
A genus of nematode worms in the superfamily Heterakoidea. A. galli and A. lineata are important intestinal parasites of domestic fowl.
Infection with nematodes of the genus HAEMONCHUS, characterized by digestive abnormalities and anemia similar to that from hookworm infestation.
A class of unsegmented helminths with fundamental bilateral symmetry and secondary triradiate symmetry of the oral and esophageal structures. Many species are parasites.
A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Determination of parasite eggs in feces.
A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
A genus of parasitic nematodes found in the digestive tract of herbivorous animals. They cause incidental infections in humans from the following species: Trichostrongylus colubriformis, T. orientalis, T. axei, and T. probolurus.
Commonly known as parasitic worms, this group includes the ACANTHOCEPHALA; NEMATODA; and PLATYHELMINTHS. Some authors consider certain species of LEECHES that can become temporarily parasitic as helminths.
Diseases of domestic and mountain sheep of the genus Ovis.
Infestation with parasitic worms of the helminth class.
An order of nematodes of the subclass SECERNENTEA. Characteristics include an H-shaped excretory system with two subventral glands.
Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.
Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.
Analogs or derivatives of bephenium (N,N-dimethyl-N-(2-phenoxyethyl)benzenemethanaminium).
Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.
Antinematodal agent used mainly for livestock.
A species of parasitic nematode usually found in domestic pigs and a few other animals. Human infection can also occur, presumably as result of handling pig manure, and can lead to intestinal obstruction.
A species of parasitic nematode that is the largest found in the human intestine. Its distribution is worldwide, but it is more prevalent in areas of poor sanitation. Human infection with A. lumbricoides is acquired by swallowing fully embryonated eggs from contaminated soil.
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.
A genus of parasitic nematodes occurring in the stomach of ruminants.
A superfamily of nematode parasitic hookworms consisting of four genera: ANCYLOSTOMA; NECATOR; Bunostomum; and Uncinaria. ANCYLOSTOMA and NECATOR occur in humans and other mammals. Bunostomum is common in ruminants and Uncinaria in wolves, foxes, and dogs.
A genus of nematode intestinal parasites that consists of several species. A. duodenale is the common hookworm in humans. A. braziliense, A. ceylonicum, and A. caninum occur primarily in cats and dogs, but all have been known to occur in humans.
A subclass of segmented worms comprising the tapeworms.
Infestation with nematode worms of the genus TRICHOSTRONGYLUS. Man and animals become infected by swallowing larvae, usually with contaminated food or drink, although the larvae may penetrate human skin.
Diseases of the domestic or wild goat of the genus Capra.
A genus of nematode worms comprising the whipworms.
Infection of horses with parasitic nematodes of the superfamily STRONGYLOIDEA. Characteristics include the development of hemorrhagic nodules on the abdominal peritoneum.
Broad spectrum antinematodal anthelmintic used also in veterinary medicine.
An anthelmintic used in most schistosome and many cestode infestations.
2-Hydroxy-N-phenylbenzamides. N-phenyl substituted salicylamides. Derivatives have been used as fungicides, anti-mildew agents and topical antifungal agents. In concentrated form may cause irritation of skin and mucous membranes.
A superfamily of nematodes. Most are intestinal parasites of ruminants and accidentally in humans. This superfamily includes seven genera: DICTYOCAULUS; HAEMONCHUS; Cooperia, OSTERTAGIA; Nematodirus, TRICHOSTRONGYLUS; and Hyostrongylus.
Cyanomethylamine.
Infection of humans or animals with hookworms of the genus ANCYLOSTOMA. Characteristics include anemia, dyspepsia, eosinophilia, and abdominal swelling.
Drugs used to treat or prevent parasitic infections.
A plant genus of the family LAMIACEAE. Members contain teuscordonin. There have been reports of hepatoxicity by this genus.
Infections with nematodes of the order ASCARIDIDA.
A genus known for fibers obtained from their leaves: sisal from A. sisalana, henequen from A. fourcroyoides and A. cantala, or Manila-Maguey fiber from A. cantala. Some species provide a sap that is fermented to an intoxicating drink, called pulque in Mexico. Some contain agavesides.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Infections with true tapeworms of the helminth subclass CESTODA.
Infections with nematodes of the order STRONGYLIDA.
A superfamily of polymyarian nematode worms. An important characteristic of this group is the presence of three prominent lips around the mouth of the organism.
A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain acetogenins and benzoquinazoline and other alkaloids.
A superfamily of nematodes of the order STRONGYLIDA. Characteristics include a fluid-filled outer layer of cuticle and a reduced mouth and bursa.
Tests that demonstrate the relative effectiveness of chemotherapeutic agents against specific parasites.
The Indian plum plant family of the order Violales, subclass Dilleniidae class Magnoliopsida, that are tropical and subtropical trees and shrubs.
A plant genus of the family ASTERACEAE that has long been used in folk medicine for treating wounds.
A superfamily of parasitic nematodes which were formerly considered a part of TRICHOSTRONGYLOIDEA. It includes the following genera: Heligmosomum, NEMATOSPIROIDES, and NIPPOSTRONGYLUS. The hosts are rodents.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Infection by roundworms of the superfamily TRICHOSTRONGYLOIDEA, including the genera TRICHOSTRONGYLUS; OSTERTAGIA; Cooperia, HAEMONCHUS; Nematodirus, Hyostrongylus, and DICTYOCAULUS.
A genus of parasitic nematodes widely distributed as intestinal parasites of mammals.
A genus of nematodes of the superfamily STRONGYLOIDEA, parasitic in the intestines of animals. The adults are usually free in the intestinal lumen; the larvae encyst in the wall.
Compounds with a BENZENE fused to IMIDAZOLES.
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida. They have leaflike appendages at the base of the leafstalks, have terminal flower clusters. Petals have four or five overlapping lobes and the fruit is a capsule containing winged or wingless seeds.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A disease of herbivorous mammals, particularly cattle and sheep, caused by stomach worms of the genus OSTERTAGIA.
Agents used to treat tapeworm infestations in man or animals.
The heath plant family of the order Ericales, subclass Dilleniidae, class Magnoliopsida that are generally shrubs or small trees. Leaves are alternate, simple, and leathery; flowers are symmetrical with a 4- or 5-parted corolla of partly fused petals.
Infection with tapeworms of the genus Hymenolepis.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48)
A plant genus of the family POACEAE which is a source of citronella oil and lemongrass oil.
Compounds consisting of chains of AMINO ACIDS alternating with CARBOXYLIC ACIDS via ester and amide linkages. They are commonly cyclized.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mostly trees and shrubs growing in warm areas.
A plant genus of the family SCROPHULARIACEAE.
A plant species of the genus MELIA, family MELIACEAE, which is toxic to insects. The name is very similar to Melia azadirachta (AZADIRACHTA).
A genus of nematodes of the superfamily ASCARIDOIDEA whose species usually inhabit the intestine.
2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)
Diseases of domestic and wild horses of the species Equus caballus.
A broad range of biologically active compounds which occur naturally in plants having important medicinal and nutritional properties.
A plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida composed of tropical plants with parallel-nerved leaves.
A plant genus of the family ZINGIBERACEAE. Members contain galangin, yakuchinone-A, and diarylheptanoids.
A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties.
A plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.
Proteins found in any species of helminth.
The rose plant family in the order ROSALES and class Magnoliopsida. They are generally woody plants. A number of the species of this family contain cyanogenic compounds.
A plant genus of the family Caricaceae, order Violales, subclass Dilleniidae, class Magnoliopsida. It is the source of edible fruit and PAPAIN.
The smallest species of TAPEWORMS. It is the only cestode that parasitizes humans without requiring an intermediate host.
Infections or infestations with parasitic organisms. The infestation may be experimental or veterinary.
A genus of intestinal nematode parasites belonging to the superfamily HELIGMOSOMATOIDEA, which commonly occurs in rats but has been experimentally transmitted to other rodents and rabbits. Infection is usually through the skin.
A plant genus of the family Lamiaceae. Inerminosides (iridoid glycosides); colebroside A; STEROIDS; STEROLS; terpenoid glucosides; and abietane DITERPENES have been found in this genus.
Drugs and their metabolites which are found in the edible tissues and milk of animals after their medication with specific drugs. This term can also apply to drugs found in adipose tissue of humans after drug treatment.
A common parasite of humans in the moist tropics and subtropics. These organisms attach to villi in the small intestine and suck blood causing diarrhea, anorexia, and anemia.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
The mahogany plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.
A species of parasitic nematode found in the intestine of dogs. Lesions in the brain, liver, eye, kidney, and lung are caused by migrating larvae. In humans, these larvae do not follow normal patterns and may produce visceral larva migrans (LARVA MIGRANS, VISCERAL).
A genus of CRUSTACEA of the order ANOSTRACA, found in briny pools and lakes and often cultured for fish food. It has 168 chromosomes and differs from most crustaceans in that its blood contains hemoglobin.
A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.
Ruminant mammals of South America. They are related to camels.
Infection with nematodes of the genus STRONGYLOIDES. The presence of larvae may produce pneumonitis and the presence of adult worms in the intestine could lead to moderate to severe diarrhea.
A class of annelid worms with few setae per segment. It includes the earthworms such as Lumbricus and Eisenia.
A subclass of ion channels that open or close in response to the binding of specific LIGANDS.
A species of parasitic nematode widely distributed in tropical and subtropical countries. The females and their larvae inhabit the mucosa of the intestinal tract, where they cause ulceration and diarrhea.
Polyketides of up to a few dozen carbons in length, formed by chain extension of multiple PROPIONATES and oxygenated to form tetrahydrofuran and lactone rings along the length of the chain. They are found in ANNONACEAE and other PLANTS. Related compounds cyclize to MACROLIDES.
Agents that act systemically to kill adult schistosomes.
The science of breeding, feeding and care of domestic animals; includes housing and nutrition.
Infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus TAENIA (primarily T. solium in humans). Lesions formed by the organism are referred to as cysticerci. The infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. SEIZURES represent the most common clinical manifestation although focal neurologic deficits may occur. (From Joynt, Clinical Neurology, 1998, Ch27, pp46-50)
Infections or infestations with parasitic organisms. They are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.
A species of nematode that is widely used in biological, biochemical, and genetic studies.
Large, hoofed mammals of the family EQUIDAE. Horses are active day and night with most of the day spent seeking and consuming food. Feeding peaks occur in the early morning and late afternoon, and there are several daily periods of rest.
Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.
The co-occurrence of pregnancy and parasitic diseases. The parasitic infection may precede or follow FERTILIZATION.
Species of tapeworm in the genus TAENIA, that infects swine. It is acquired by humans through the ingestion of cured or undercooked pork.
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
A republic in western Africa, south of MALI and BURKINA FASO, bordered by GHANA on the east. Its administrative capital is Abidjan and Yamoussoukro has been the official capital since 1983. The country was formerly called Ivory Coast.
A republic in eastern Africa, south of UGANDA and north of MOZAMBIQUE. Its capital is Dar es Salaam. It was formed in 1964 by a merger of the countries of TANGANYIKA and ZANZIBAR.

Neurocysticercosis in an Italian traveler to Latin America. (1/1248)

Neurocysticercosis is rarely reported in short-term travelers, although the disease remains a major public health problem in tropical regions. We present a case of neurocysticercosis that was probably acquired by ingestion of Taenia solium eggs contained in the stomach of a pig butchered by the traveler. Complete clinical resolution was obtained by medical treatment, underlying the importance of early suspicion and diagnosis of the disease.  (+info)

Ivermectin distribution using community volunteers in Kabarole district, Uganda. (2/1248)

Ivermectin mass distribution for the control of onchocerciasis in Uganda began in 1991. This report describes a community based ivermectin distribution programme covering two foci in the Kabarole district which have an estimated 32,000 persons infected and another 110,000 at risk. Through nodule palpation in adult males, 143 villages were identified where nodule prevalence exceeded 20%. Skin snips were also taken from a sample of the population to measure changes in community microfilarial load (CMFL) with treatment. The delivery programme was integrated into the district health management structure, and used community volunteers supervised by medical assistants from adjacent health facilities for annual ivermectin distribution campaigns. After initial efforts by the community to support distributors in-kind proved inadequate, ivermectin distributors earned money retailing condoms as part of the social marketing component of district STD/AIDS programme. Reduction in the CMFL ranged from 40-62% twelve months after the second ivermectin treatment in three villages, and from 69-84% six months after the fourth round of treatment in two villages. After four years of treatment, 85% of eligible persons were receiving ivermectin from community volunteers in each treatment cycle. Drop out rates among volunteers did not exceed 20% over the four years reported here. The direct cost of treatment was US $0.29 per person. Among the reasons for low per-person treatment costs were the strong supervisory structure, the presence of health centres in the foci and a well developed and capable district Primary Health Care management team.  (+info)

Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. (3/1248)

The metacestode stage of Echinococcus multilocularis is the causative agent of alveolar echinococcosis (AE), a parasitic disease affecting the liver, with occasional metastasis into other organs. Benzimidazole carbamate derivatives such as mebendazole and albendazole are currently used for chemotherapeutic treatment of AE. Albendazole is poorly resorbed and is metabolically converted to its main metabolite albendazole sulfoxide, which is believed to be the active component, and further to albendazole sulfone. Chemotherapy with albendazole has been shown to have a parasitostatic rather than a parasitocidal effect; it is not effective in all cases, and the recurrence rate is rather high once chemotherapy is stopped. Thus, development of new means of chemotherapy of AE is needed. This could include modifications of benzimidazoles and elucidiation of the respective biological pathways. In this study we performed in vitro drug treatment of E. multilocularis metacestodes with albendazole sulfoxide and albendazole sulfone. High-performance liquid chromatography analysis of vesicle fluids showed that the drugs were taken up rapidly by the parasite. Transmission electron microscopic investigation of parasite tissues and nuclear magnetic resonance spectroscopy of vesicle fluids demonstrated that albendazole sulfoxide and albendazole sulfone had similar effects with respect to parasite ultrastructure and changes in metabolites in vesicle fluids. This study shows that the in vitro cultivation model presented here provides an ideal first-round test system for screening of antiparasite drugs.  (+info)

Effect of anthelmintic treatment on sexual maturation in prepubertal beef heifers. (4/1248)

Heifers treated with ivermectin at weaning have been reported to reach puberty at a younger age and lighter weight than untreated heifers. We tested the hypothesis that heifers administered ivermectin would respond with earlier follicular development and a greater LH response to a 1-mg estradiol-17beta challenge (E2C) than untreated heifers. Fall-born Angus heifers (n = 32) were randomly assigned on 284 +/- 9 d of age (215.5 +/- 20.8 kg) to receive ivermectin (IVR) or albendazole (ALB), IVR + ALB, or to remain as untreated controls (CONT). Each group (n = 8) was housed separately in adjacent pens throughout the trial and managed to gain .8 kg/heifer on a ration containing 13.2% CP, 58.8% TDN, and 49.9% DM. The CONT heifers received an additional 2.27 kg/heifer of corn silage and 1.59 kg/heifer of corn daily to maintain ADG at comparable levels. Individual body weight was recorded weekly, and nematode eggs per gram (EPG) of feces were measured every 21 d. Ultrasonography was performed on alternate days starting 2 wk prior to E2C to characterize follicular wave patterns. Follicles were separated into classes (C1 [3 to 5 mm], C2 [6 to 9 mm], and C3 [10 mm]) and sizes (largest [LF], second [SLF], third [TLF], and fourth largest follicles [FLF]). The sizes of the regressing dominant follicle 1 (DF1) and the progressing dominant follicle 2 (DF2) were also determined. Serum concentrations of LH were determined from hourly jugular blood samples collected 8 to 24 h after injection of E2C. The IVR + ALB treatment group had more C3 follicles than ALB and CONT (P < .07). The IVR-treated heifers had larger TLF than ALB and CONT (P < .04). The IVR- and IVR + ALB-treated heifers had larger FLF and DF2 than ALB and CONT (P < .1). Least squares means for DF2 were 9.5 +/- .5, 8.0 +/- .4, 9.5 +/- .3 and 8.3 +/- .3 mm, for IVR, ALB, IVR + ALB and CONT, respectively (P = .02 for treatment effect). The E2C-induced serum LH concentration did not differ with respect to treatment. We conclude that heifers administered IVR display increased follicular development, supporting our earlier investigations regarding reduced age at puberty in heifers treated with IVR near weaning.  (+info)

Cost of school-based drug treatment in Tanzania. The Partnership for Child Development. (5/1248)

It has been argued that targeting delivery of anthelmintics to school-children by taking advantage of the existing education infrastructure and administrative system can be one of the most cost-effective approaches in minimizing the intensity of infections with both schistosomiasis and major intestinal nematodes in many developing countries. The study was conducted in January 1997, shortly after the completion of the drug intervention programme. This paper provides an analysis of the costs of providing age-targeted treatment of school-children for urinary schistosomiasis using praziquantel and for intestinal nematodes using albendazole as an integral part of the School Health Programme in Tanga Region, Tanzania. The analysis shows that the total financial cost of the intervention programme in 1996 prices was US$54 252.28 (exchange rate: TSH 573 = US$1). Of this amount, the cost of drugs constitutes 80.6%, while the delivery cost appears relatively low, representing just below 20%. Even when the opportunity cost of unpaid days of labour input is included, the cost of drugs still remains the highest cost component of the intervention (55.8%). In the current epidemiological and logistic setting of Tanzania, the financial cost per child treated using praziquantel, which involved prior screening at the school level, was US$0.79, while treatment using albendazole was as low as US$0.23, of which US$0.20 was drug purchase cost. It is concluded that the base cost of delivering a universal, standard, school-based health intervention such as albendazole can be as low as US$0.03 per child tested, but even a very slight increase in the complexity of delivery can have a very significant impact on the cost of intervention.  (+info)

Evidence for an improvement in cognitive function following treatment of Schistosoma japonicum infection in Chinese primary schoolchildren. (6/1248)

A double-blind, placebo-controlled, treatment trial was conducted in Sichuan, China to investigate the unique and combined effects on the cognitive function (working memory) of children after treating geohelminth infections with albendazole and treating Schistosoma japonicum infection with praziquantel. One hundred eighty-one children 5-16 years of age participated. At baseline, the praziquantel and placebo groups were similar in all background characteristics. Three months after praziquantel treatment, there was a significant reduction in the prevalence and intensity of S. japonicum infection. There were significant age group by praziquantel treatment interaction effects in three of the five cognitive tests, Fluency, Picture Search, and Free Recall, with effects being strongest in the youngest children (5-7 years old). Exploratory analysis within the youngest children showed a significant positive main effect of treatment on Fluency (P < 0.001), after controlling for sex, anthropometric, and parasitic and iron status. There was also a treatment by height-for-age interaction (P = 0.03) and a treatment by iron status interaction (P = 0.024) on Fluency. There was a treatment by S. japonicum intensity interaction (P < 0.001) on Free Recall, but the main effect of treatment on Picture Search was not significant (P = 0.058). Younger children and those who are physically the most vulnerable are likely to benefit the most from the treatment of S. japonicum infection in terms of improved performance on tests of working memory.  (+info)

Presystemic metabolism of albendazole: experimental evidence of an efflux process of albendazole sulfoxide to intestinal lumen. (7/1248)

Albendazole (ABZ) presystemic clearance was studied in rat by perfusion of a 25 microM ABZ solution in isolated intestinal loops. Significant secretion of the active metabolite, ABZSO, into the lumen was observed. The metabolite was also present in mesenteric blood. After 30 min of intestinal perfusion, 64% of the ABZ dose had disappeared from lumen. The total amount of ABZSO measured was 0.341 +/- 0.04 nmol/cm with 0.176 +/- 0.03 nmol/cm in mesenteric blood. The metabolite secretion to intestinal lumen was 0.165 +/- 0.05 nmol/cm. Intestinal sulfoxidation was induced by repeated administration of ABZ and ABZ coadministered with surfactants, especially polysorbate 80. The enantioselectivity of the in vitro intestinal sulfoxidation of ABZ showed that the relative contribution of P-450 and flavin-containing monooxygenase was quite similar, but after the induction by ABZ coadministered with polysorbate 80, the cytochrome P-450 system contribution was significantly increased. The appearance of ABZSO in mesenteric blood clearance was also increased under these conditions.  (+info)

Population biology of human onchocerciasis. (8/1248)

Human onchocerciasis (river blindness) is the filarial infection caused by Onchocerca volvulus and transmitted among people through the bites of the Simulium vector. Some 86 million people around the world are at risk of acquiring the nematode, with 18 million people infected and 600,000 visually impaired, half of them partially or totally blind. 99% of cases occur in tropical Africa; scattered foci exist in Latin America. Until recently control programmes, in operation since 1975, have consisted of antivectorial measures. With the introduction of ivermectin in 1988, safe and effective chemotherapy is now available. With the original Onchocerciasis Control Programme of West Africa coming to an end, both the new African Programme for Onchocerciasis Control and the Onchocerciasis Elimination Programme for the Americas, rely heavily on ivermectin self-sustained mass delivery. In consequence, the need for understanding the processes regulating parasite abundance in human and simuliid populations is of utmost importance. We present a simple mathematical framework built around recent analyses of exposure- and density-dependent processes operating, respectively, within the human and vector hosts. An expression for the basic reproductive ratio, R0, is derived and related to the minimum vector density required for parasite persistence in localities of West Africa in general and northern Cameroon in particular. Model outputs suggest that constraints acting against parasite establishment in both humans and vectors are necessary to reproduce field observations, but those in humans may not fully protect against reinfection. Analyses of host age-profiles of infection prevalence, intensity, and aggregation for increasing levels of endemicity and intensity of transmission in the Vina valley of northern Cameroon are in agreement with these results and discussed in light of novel work on onchocerciasis immunology.  (+info)

A wide variety of dog anthelmintic options are available to you, such as cattle, aquatic animals, and omucoxideh. Utilizarea prea frecventă a unor antihelmintice din aceeaşi clasă, an anthelmintic agent o an anthelmintic agent. Consequently, symptoms like retarded cognitive development, iron-deficiency anaemia, abdominal pains and.
While surveys in Southern Africa indicate anthelmintic resistance of gastrointestinal nematodes to be common in small ruminants in South Africa, Kenya and Zimbabwe, there have been no reports of resistance in Zambia. The objective of this study was to determine whether anthelmintic resistance occurs in Zambia, and to obtain information on nematode control practices in the country. During the rainy season six commercial sheep farms were selected in and around Lusaka and Chisamba. Worm control practices were gauged by means of a questionnaire, and the Faecal Egg Count Reduction Test was performed for assessing anthelmintic efficacy of albendazole, levamisole and ivermectin. On all farms, anthelmintic treatment was the only approach used to control nematode infections. Frequency of treatment varied from twice a year to every 6 weeks and drugs of different anthelmintic groups were alternated within the same year. There was a wide range in faecal egg counts of individual sheep before treatment, with ...
Dear all,. This is to invite you to Stella Kephas PhD defence which will take place next Thursday 24th March 2016 as per details below. Stella Kepha is a PhD student based at the School of Public Health. Kindly reserve the date:. Presenter: Stella Kepha. Topic: Effect of anthelminthic treatment on malaria on school children in Kenya: a randomized, open label, equivalence trial.. Time: 9:00 am-12:00pm. Date: 24th March 2016. Opponent: Assoc Prof: Sarah Staedke, London School of Hygiene Tropical Medicine. ...
Objective To establish the prevalence of anthelmintic resistance in ovine gastrointestinal nematodes in southern Queensland. Design An observational parasitological study using the faecal egg count reduction test. Methods Sheep farms (n = 20) enrolled in this study met the twin criteria of using worm testing for drench decisions and having concerns about anthelmintic efficacy. On each farm, 105 sheep were randomly allocated to one of six treatment groups or an untreated control group. Faecal samples were collected on day 0 and days 10-14 for worm egg counts and larval differentiation. Single- and multi-combination anthelmintics, persistent and non-persistent, oral liquid or capsule, pour-on and injectable formulations were tested. Monepantel was not tested. Farmers also responded to a questionnaire on drenching practices. Results Haemonchus contortus was the predominant species. Efficacy ,95% was recorded on 85% of farms for one or more anthelmintics and on 10% of farms for six anthelmintics. No ...
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Before revised World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines on the detection of anthelmintic resistance can be produced, validation of modified and new methods is required in laboratories in different parts of the world. There is a great need for improved methods of detection of anthelmintic resistance particularly for the detection of macrocyclic lactone resistance and for the detection of resistant nematodes in cattle. Therefore, revised and new methods are provided here for the detection of anthelmintic resistance in nematodes of ruminants, horses and pigs as a basis for discussion and with the purpose that they are evaluated internationally to establish whether they could in the future be recommended by the WAAVP. The interpretation of the faecal egg count reduction test has been modified and suggestions given on its use with persistent anthelmintics and continuous release devices. An egg hatch test for benzimidazole (BZ) resistance is described. A ...
Approximately 10% of sheep producers in Ireland [20] participated in the STAP drench test task. To the authors knowledge, this is the largest field survey investigating anthelmintic inefficacy in the world to date and provides some baseline valuable data on treatment failure in Irish flocks. While the FECRT [6] is still regarded as the method of choice to investigate anthelmintic efficacy, the drench test employed in this survey represents a cost-effective modified version where samples from each flock were pooled instead of analysed separately by the laboratory, the results of which should be interpreted as an indicator of anthelmintic treatment failure and not anthelmintic resistance per se [21].. The majority of drench tests were carried out in the border and west regions, representing the areas of Ireland where the majority of sheep farming is conducted [20]. In the first year only 28% of the drench tests were carried out according to the instructions provided. Compliance improved in ...
Define anthelmintic. anthelmintic synonyms, anthelmintic pronunciation, anthelmintic translation, English dictionary definition of anthelmintic. also ant·hel·min·thic adj. Acting to expel or destroy parasitic intestinal worms. n. An agent that destroys or causes the expulsion of parasitic intestinal...
A recent national survey on anthelmintic resistance in cattle and sheep in New Zealand indicated that the magnitude of the problem has increased from very low levels only a few years ago to disturbingly high levels now. There is a particular problem with multiple resistance to all three action families of anthelmintic currently available in Ostertagia (= Teladorsagia) spp in sheep, and to both macrocyclic lactones (ML) and benzimidazoles in Cooperia spp in cattle. The prevalence and extent of resistance indicate that all cattle farmers and most sheep farmers should now be using a combination anthelmintic on most occasions just to achieve effective control of all parasites. Despite this, die presence of resistant parasites has generally not been appreciated by the majority of affected farmers, possibly because most have not formally tested to determine die resistance status of nematodes on their farms. Anthelmintics will remain the cornerstone of gastrointestinal nematode control in sheep and ...
Play media Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. They may also be called vermifuges (those that stun) or vermicides (those that kill). Anthelmintics are used to treat people who are infected by helminths, a condition called helminthiasis. These drugs are also used to treat infected animals. Pills containing anthelmintics are used in mass deworming campaigns of school-aged children in many developing countries. For example, the treatment of choice for soil-transmitted helminths is mebendazole and albendazole and praziquantel for schistosomiasis. Antiparasitics that specifically target Ascaris worms are called ascaricides. Benzimidazoles: Albendazole - effective against threadworms, roundworms, whipworms, tapeworms, hookworms Mebendazole - effective against pinworms, roundworms and hookworms ...
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Internal parasites of horses comprise an intractable problem conferring disease, production and performance losses. Parasitism can rarely be controlled in grazing horses by management alone and anthelmintic drugs have formed the basis of therapy and prophylaxis for the last sixty years. The pharmacology of the anthelmintic drugs available dictate their spectrum of activity and degree of efficacy, their optimal routes of administration and characteristics which prevent some routes of administration, their safety tolerance and potential toxicities and as a consequence of their persistence in the body at effective concentrations their use in epidemiological control programmes. Their use has also resulted in the selection of parasites with genetically controlled characteristics which reduce their susceptibility to treatment, characteristics which are often common to whole chemical classes of anthelmintics. Pharmacological properties also confer compatibility in terms of safety and persistence with ...
Biology 18 Spring, 1 Lab 4 - Comparison of Parasitic and Free-Living Worms Objectives: Understand the taxonomic relationships and major features of the worm phyla, Platyhelminthes, Nematoda and Annelida Learn the external and internal anatomy of Dugesia, Antihelminthic drugs ppt, and Ascaris and become familiar with the external features of the other specimens.
Background Between 2013 and 2015 the Department of Agriculture, Food and the Marine (DAFM) administered a sheep technology adoption programme (STAP), with the aim of increasing profitability on Irish sheep farms by encouraging the adoption of best management practices. One of the options available to STAP participants was to test the efficacy of the anthelmintic treatment (benzimadazole, levamisole or macrocyclic lactone) used in their flocks by means of a drench test, which is a modification of the faecal egg count reduction test; individual faecal samples were collected from the same group of lambs before and after anthelmintic treatment, the number of eggs present pre and post treatment was subsequently determined from a pooled sample. Results In total, 4211 drench tests were undertaken by farmers during the 3 years of the programme. Information on the anthelmintic product used was available for 3771 of these tests; anthelmintics from the classes benzimidazole (BZ), levamisole (LV) and ...
Gastrointestinal parasitism is a widely recognised problem in sheep production, particularly for lambs. While anthelmintics have a pivotal role in controlling the effects of parasites, there is a paucity of data on how farmers use anthelmintics. A representative sample of Irish lowland farmers were surveyed regarding their parasite control practices and risk factors that may contribute to the development of anthelmintic resistance. Questionnaires were distributed to 166 lowland Irish sheep producers. The vast majority of respondents treated their sheep with anthelmintics. Lambs were the cohort treated most frequently, the majority of farmers followed a set programme as opposed to treating at sign of disease. A substantial proportion (61%) administered four or more treatments to lambs in a normal year. Departures from best practice in anthelmintic administration that would encourage the development of anthelmintic resistance were observed. In conclusion, in the light of anthelmintic resistance, ...
Wart virus in shoes crijevni paraziti kod djece, hpv avec condylome laryngeal papillomatosis virus. Implementarea acestuia se bazează pe analizarea frecvenței de apariție a termenului «anthelmintic» în sursele digitalizate tipărite în Engleză între anul și până în prezent. In: Phytother.
A novel series of 1,2,5-trisubstituted benzimidazole derivatives was synthesized by coupling 2-mercapto-5-methoxybenzimidazol-1-acetic acid with several amino acid methyl ester hydrochlorides/dipeptides/tripeptides using dicyclohexylcarbodiimide (DCC) as the coupling agent and triethylamine (TEA) as the base. All newly synthesized compounds were characterized by spectral as well as elemental analysis and evaluated for their biological potential. Compounds 5, 8 and 12 were found to exhibit potent anthelmintic activity against M. konkanensis, P. corethruses and Eudrilus sp. in comparison to standard drug - mebendazole. Moreover, compounds 7, 9 and 13 possessed potent antifungal activity against C. albicans and compounds 4 and 10 displayed good activity against pathogenic bacteria P. aeruginosa. Gram negative bacteria were found to be more sensitive in comparison to gram positive bacteria towards the newly synthesized benzimidazolopeptide analogs ...
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With almost 2,000 farmers opting to complete the drench test task as one of their two technical tasks for inclusion in the STAP programme it became the most popular task. Despite this encouraging response, compliance with task instructions was low (27.8% n = 527). While, 16% of participants submitted only one sample, almost 15% of farmers did not report which anthelmintic product they used and the efficacy of these treatments could not be included in the study. Approximately 2% of farmers used an inappropriate product, such as a product active only as a flukicide or a combination (BZ/LEV) anthelmintic, and were also excluded from the study. A further 39.6% of farmers either did not provide information on time of sampling or did not meet the criteria concerning timeframes pre- and post-treatment (10-14, 4-7 or 14-18 days for BZ, LEV and ML products, respectively).. Over 1300 farmers reported which anthelmintic product they used and amongst those farmers 46% used a BZ product, making this drug ...
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SYNTHESIS, CHARACTERIZATION AND ANTHELMINTIC ACTIVITY OF NOVEL 3-BENZYL-2-(4- SUBSTITUTED PHENYL)-4(5H)-(4-NITROPHENYL AMINO)-1, 3-OXAZOLIDINES DERIVATIVES
Nematode parasites exist for nearly every agriculturally important animal and plant on earth, and currently infect over 2 billion people. Resistance to existing anthelmintics is rapidly growing and the need to develop novel anthelmintics is pressing. To identify potential anthelmintic leads, we screened the 600+ bioactive molecules that we have identified using C. elegans in the bovine parasitic nematode Cooperia oncophora in collaboration with John Gilleard (Calgary). C. oncophora also serves as a model for several nematode parasites of humans. We counter-screened our bioactive molecules in preliminary models of parasitic hosts, including zebrafish and a human cell line. We discovered 73 compounds that: i) kill both C. elegans and C. oncophora; ii) fail to induce obvious phenotypes in fish or HEK293 cells; and iii) have no obvious structural relationship to any characterized anthelmintic. Our work now focuses on exploiting C. elegans genetics and whole-genome sequencing to identify the target ...
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The bark extracts of Prosopis staphaniana have been investigated for their anthelmintic activity aganist Pheretima posthuma. The different concentrati..
lbendazole + Ivermectin Bolus, is a powerful antiparasitic combination therapy indicated for treatment against worms. In bolus form, they are used against a wide range of parasitic worm infestations in animals. As a broad spectrum anthelmintic...
The continued existence of New Zealands critically endangered and endemic black stilt or kakï (Himantopus novaezelandiae) relies on an intensive captive management programme. While this is successful at rearing large numbers of birds for release to the wild, poor survivability of these birds is limiting significant increases in the wild population. Predation and starvation are suspected to be the most common causes of death in released birds, but underlying contributing factors to these mortalities have not been fully evaluated. This research investigates the possible contribution of gastrointestinal (GI) helminth burdens and suboptimal digestive organ development to the high mortality rates of released kakï. Emphasis is placed on evaluating the methods used to assess the importance of these factors and to make informed recommendations for future management. The efficacy of the anthelmintic regime used for kakï was assessed by dosing half of the 80 captive birds with praziquantel (PZQ) prior ...
Anthelmintic resistance in nematodes can be a problem in sheep, goats, horses, cattle and pigs. The most widespread resistance problems occur to benzimidazol anthelmintics in nematodes of sheep, goats and horses. Reports of this type of resistance have emanated from Australia. Africa, Europe North and South America; wherever animals are regularly treated with anthelmintics and investigation have been made. Beveridge et al. (1990), Eady et al. (1998), Rolfe (1993) and Waller et al.( !986) found a high level of benzimidazole resistance in gastro-intestinal nematodes in sheep in Australia. In Europe an increasing incidence of anthelmintic resistance in sheep were reported in Great Britain (Coles 1997, Hunt et al. 1992), in France (Guerin 1996) and in Denmark (Maingi et al. 1997). In USA benzimidazole resistance of gastro-intestinal nematodes in sheep were found in North Carolina (Uhlinger et al. 1992) and in eastern region (Lyons et al. 1992). Benzimidazole resistance in cyathostomes in horses has ...
Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for anthelmintic activity against the soil nematode Ca …
Anthelmintics are drugs that are used to treat infections with parasitic worms. This includes both flat worms, e.g., flukes and tapeworms and round worms, i.e.,
Description: Solas (Mabendazole) is an effective and versatile broad spectrum anthelmintic agent; it eradicates warms by inhibiting nutrition uptake irreversibly. It is safe even in anaemic and mainutritive patients due to its negligible absorption...
The anthelmintic agent ivermectin, tested in the EPIC (: Estudio Para Evaluar la Ivermectina en) COVID-19 trial of 476 patients, did not significantly shorten symptom duration in adults with mild COVID-19.
Endospec 10% SC with the selenium and colbalt is a broad spectrum multi purpose anthelmintic for the control of mature and developing immature forms of gastrointestinal roundworms, lungworms, tapewormsand adult liver fluke in cattle and ...
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N-[2-(Substituted amido)phenyl]-N,N-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N,N-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.
So why is resistance a growing issue? As discussed already, many individuals have relied exclusively on one type of dewormer. Eventually, as is typical in nature, organisms adapt to their environment to be more successful and to pass on their genetic code to future generations. Essentially, once the worms adapt, or a few individuals survive a purge deworming, they are able to pass on these enhanced genetics to a future generation of worms which will also have that advantage of being immune to that drug. If they are never exposed to a different type of dewormer, essentially the horse owner is just developing a breeding program for resistant worms! One strategy to adopt when thinking about breeding worms is to increase the number of refugia, or the population of worms which have not been exposed to dewormers. These would be the worms that would be in horses that were untreated, the encysted larval stages or perhaps those in the pasture. These non-exposed worms actually help to dilute out the ...
Helminths are arguably the most important parasites affecting livestock production throughout the world causing a range of disorders which particularly affect the productivity, fertility and welfare of farmed ruminants. Gastro-intestinal nematodes can cause scouring, reductions in appetite and ill thrift and have been estimated to cost the British sheep industry around 84 million pounds per annum, based upon the costs of lost production, preventive measures and treatment of affected animals.
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The objective of the Health Products Regulatory Authority is to ensure in so far as possible, consistent with current medical and scientific knowledge, the quality, safety and efficacy of medicines available in Ireland and to participate in systems designed to do that throughout the European Union.
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Approximately 40 new comedications have been added to the web and app versions of the interaction charts (the printable charts will be updated in next few weeks). Details of the new drugs are listed below.. Anthelmintics: ivermectin, ...
Tailored horse worming programmes ensure specific worms are targeted with an effective product at the right time. This article outlines the four main classes of anthelmintics (horse wormers) and advice on how to worm throughout the year.
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ABSTRACT. A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed sheep in a semi-arid area near Mafikeng South Africa, from January to March 2006. In the herds belonging to twelve smallholder sheep farmers, the efficacies of albendazole, levamisole and closantel were tested by faecal egg count reduction tests where 80 % efficacy was considered the cut off for anthelmintic resistance. The results of the faecal egg count reduction tests showed more than 80 % efficacy with all the drugs used in most cases, but there were notable exceptions. In 1 case, closantel had an efficacy of 72%, albendazole had an efficacy of 68 % and levamisole showed efficacies of 58%, 60% and 75 =% respectively on 4 farms. The occurrence of anthelmintic resistance in this farming sector is of concern and steps should be taken to prevent its further spread and development to avoid a situation developing as on numerous commercial sheep farms in South Africa where resistance is ...
List of Tables. Table 1. Global Albendazole Anthelmintic Drug Revenue (USD Million) by Type: 2015 VS 2019 VS 2025. Table 2. Breakdown of Albendazole Anthelmintic Drug by Company Type (Tier 1, Tier 2 and Tier 3). Table 3. Global Albendazole Anthelmintic Drug Market Size and Growth Estimation in Various Scenarios in 2020. Table 4. Global Albendazole Anthelmintic Drug Revenue (USD Million) by Application: 2015 VS 2019 VS 2025. Table 5. Market Opportunities in Next Few Years. Table 6. Market Risks Analysis. Table 7. Market Drivers. Table 8. GlaxoSmithKline Basic Information, Manufacturing Base and Competitors. Table 9. GlaxoSmithKline Albendazole Anthelmintic Drug Major Business. Table 10. GlaxoSmithKline Albendazole Anthelmintic Drug Total Revenue (USD Million) (2018-2019). Table 11. GlaxoSmithKline SWOT Analysis. Table 12. GlaxoSmithKline Albendazole Anthelmintic Drug Product and Services. Table 13. GlaxoSmithKline Albendazole Anthelmintic Drug Sales, Price, Revenue, Gross Margin and Market Share ...
The practice of traditional medicine is as old as the human race and plants are an important source of research and development of new drugs. Anthelmintic resistance in human and animal pathogenic helminths has been spreading in prevalence and severity to a point where there is multi-drug resistance against the three major classes of anthelmintics. It has become a global phenomenon in gastrointestinal nematodes of farm animals, and hence the need for novel anthelmintic products. The objectives of this study were to document plants which are commonly used in the treatment and control of helminthosis in Loitoktok District of Kenya and to determine the bioactivity, anthelmintic efficacy and preliminary phytochemistry of herbal remedies from selected plants from the study area. An ethnopharmacological study was done through gathering information from 23 traditional health practitioners from across the district. Plants used traditionally as anthelmintics were identified by the traditional healers and ...
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Anthelmintic activity of crude powder, aqueous, diethyl ether and methanol extracts of Chenopodim album leaves were tested at different concentrations. All extracts showe..
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Epidemiological studies have shown inverse associations between geohelminth (intestinal helminth) infection and atopy, leading to the suggestion that geohelminths might protect against allergy. Periodic deworming of school children with anthelmintics is a widely implemented intervention and has raised concerns that such programmes could increase allergy. We investigated the effect of repeated anthelmintic treatments with albendazole over 12 months on the prevalence of atopy and clinical indices of allergy. ...
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The increasing prevalence of anthelmintic (drench) resistance in gastrointestinal parasite populations is decreasing the profitability of the Australian sheep industry. Refugia management can delay its development by not exposing a proportion of the worm population to chemical control. A dynamic-optimisation model is used to assess the economic value of refugia for management of the worm species Teladorsagia circumcincta and macrocyclic lactone drenches in an application to Western Australian sheep flocks. A low rate of refugia (2 per cent) is most profitable under standard circumstances because it slows the development of resistance, but also reduces the proportion of the flock not exposed to chemical control. Frequent drench application should remain the primary method of control. However, its efficacy should be preserved through refugia management, rather than greatly reducing treatment frequency ...
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Prevention/Control: This is based on avoiding pastures grazed by lambs during previous grazing seasons. Adult sheep are highly resistant to infection and only lambs produce significant number of eggs. Anthelmintic prophylaxis timing is guided upon environmental temperatures and disease forecasts. Typically, in normal risk situations, anthelmintic treatment should be given 3 weeks apart during May. In high risk situations, 3 anthelmintic treatments are given, extending the drenching period into June. ...
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Buy Bendex Online! Bendex is a synthetic benzimidazole derivate and anthelmintic agent. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth.
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The Fecal Egg Count Reduction Test (FECRT) is a diagnostic tool that shows how well your cattle deworming program is working. See how to conduct a FECRT here.
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Naftalofos is an insecticide and an anthelmintic. Naftalofos represents an effective therapeutic alternative for incorporation into worm control programmes.
The action of anthelmintics on parasites located outside of the alimentary canal / by Brayton Howard Ransom, Chief of the Zoological Division and Maurice C. Hall, assistant zoologist, Zoological Division ...
Comparative study on Anthelmintic property of Medicinal Plants, Asha Devi. S., Caroline Lo Yan Fung, Priya Prakash, Theodora Lydia
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Emodepside is a resistance-breaking anthelmintic of a new chemical class, the cyclooctadepsipeptides. A major determinant of its anthelmintic effect is the calcium-activated potassium channel SLO-1. SLO-1 belongs to a family of channels that are highly conserved across the animal phyla and regulate neurosecretion, hormone release, muscle contraction, and neuronal network excitability. To investigate the selective toxicity of emodepside, we performed transgenic experiments in which the nematode SLO-1 channel was swapped for a mammalian ortholog, human KCNMA1. Expression of either the human channel or Caenorhabditis elegans slo-1 from the native slo-1 promoter in a C. elegans slo-1 functional null mutant rescued behavioral deficits that otherwise resulted from loss of slo-1 signaling. However, worms expressing the human channel were 10- to 100-fold less sensitive to emodepside than those expressing the nematode channel. Strains expressing the human KCNMA1 channel were preferentially sensitive to ...
Albendazole is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body. Albendazole is used to treat certain infections caused by worms such as pork tapeworm and dog tapeworm. Albendazole may also be used for purposes not listed...
Impact of Anthelminthic Treatment in Pregnancy and Childhood on Immunisations, Infections and Eczema in Childhood: A Randomised Controlled Trial http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050325?imageURI=info:doi/10.1371/journal.pone.0050325.t002 Background Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve responses to immunisation and…
... (sometimes known as worming, drenching or "dehelmintization") is the giving of an anthelmintic drug (a wormer, ... Giving of an anthelmintic drug to a human or animal to rid them of helminths parasites ... Deworming (drenching) a sheep is usually done with a specific drenching gun that squirts an anthelmintic into the sheep's ...
"Anthelmintics". Drugs.com. Retrieved 17 November 2014. "Overview of Anthelmintics". The Merck Veterinary Manual. Merck Sharp & ... whereas Quarterly Antihelminthic Treatment Improves Growth, Appetite, and Anemia in Zanzibari Preschool Children". The Journal ... can be pre-treated with the anthelmintic drug albendazole. Areas with the highest prevalence of helminthiasis are tropical and ...
Abba K, Ramaratnam S, Ranganathan LN (17 March 2010). Abba K (ed.). "Anthelmintics for People With Neurocysticercosis". ...
Anthelmintic is any drug that acts to expel parasites mainly Helminths from the host's body through either stunning or killing ... Using an oral drench gun attached to the back of the operator Anthelmintic chemicals which are in a pack worn on the back are ... "Anthelmintic Drugs , Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5e , AccessPharmacy , McGraw- ... There are a wide range of Anthelmintic drugs that can be used however three classes are available for sale on the livestock ...
Anthelmintic drug resistance is a widespread emerging problem. Resistance has been reported to all broad spectrum anthelmintics ... Broad spectrum anthelmintics include benzimidazoles (BZs). BZs have been used since the 1960s, and resistance was detected in ... Broad spectrum anthelmintics are also effective against adult worms and larvae. There are several benzimidazoles were ... Gross, S. J.; Ryan, W. G.; Ploeger, H. W. (1999-05-22). "Anthelmintic treatment of dairy cows and its effect on milk production ...
They provide an alternative mechanism of action to current anthelmintics and the development of resistance is thought to be ... Stepek G, Behnke JM, Buttle DJ, Duce IR (July 2004). "Natural plant cysteine proteinases as anthelmintics?". Trends Parasitol. ... Behnke JM, Buttle DJ, Stepek G, Lowe A, Duce IR (2008). "Developing novel anthelmintics from plant cysteine proteinases". ... Serpins Stefins IAPs Currently there is no widespread use of cysteine proteases as approved and effective anthelmintics but ...
According to Ayurveda, the plant is anthelmintic, alexiteric, restorative, and antipyretic. It is used in the treatment of ... SEED uses Anthelmintic ; ROOT uses Nutritive Tephrosia purpurea is used as a fish poison for fishing. Its leaves and seeds ...
Anthelmintics: Used for treating certain parasitic infections; includes praziquantel Buprenorphine: Metabolized into ...
Anthelmintics can treat and prevent Trichinella infections. Trichinosis (trichinellosis) is a disease caused by tissue-dwelling ...
It is an anthelmintic.[citation needed] It has been used as a laxative and an alexiteric. The sap is used to treat acne and ...
... is an anthelmintic. Its brand name is Flutelmium which is a paste manufactured by Janssen Pharmaceutica N.V. used ...
Howes HL (June 1971). "Anthelmintic studies with pyrantel. II. Prophylactic activity in a mouse-ascaris suum test model". The ... Cochrane Infectious Diseases Group) (April 2020). "Anthelmintic drugs for treating ascariasis". The Cochrane Database of ...
... is an anthelmintic. Desapidin may occur in natural form within some plants such as Coastal woodfern, Dryopteris ...
... is an anthelmintic. It has typically been used in human and animal medicine as a standard treatment for intestinal ...
It is considered the safest of the organophosphate class of anthelmintics for use in ruminants. Bosman CH (1965). "Anthelmintic ... Enejoh OS, Suleiman MM (2017). "Anthelmintics and their Application in Veterinary Medicine" (PDF). Research in Medical & ...
A serendipitous discovery was made in China in the early 1980s while searching for novel anthelmintics for schistosomiasis that ... Artemisinin and its derivatives are all potent anthelmintics. Artemisinins were later found to possess a broad spectrum of ...
CS1 maint: discouraged parameter (link) LAL, M. B. (19 April 1947). "Acanthocephala of Trout and Anthelmintics : Behaviour in ...
Conterno LO, Turchi MD, Corrêa I, Monteiro de Barros Almeida RA (April 2020). "Anthelmintic drugs for treating ascariasis". ... Martin RJ, Robertson AP, Choudhary S (January 2021). "Ivermectin: An Anthelmintic, an Insecticide, and Much More". Trends ...
Chen, Wei; Mook, Robert A.; Premont, Richard T.; Wang, Jiangbo (January 2018). "Niclosamide: Beyond an antihelminthic drug". ... Alternative methods for treating coenurosis include administering anthelmintics and glucocorticoids to the patients. ...
Holden-Dye, Lindy; Walker, Robert J. "Anthelmintic drugs". WormBook. Retrieved 23 May 2018. Scholar, Eric M.; Pratt, William B ...
Rao, VS; Seshadri, TR (1947). "Kamala dye as an anthelmintic". Proceedings of the Indian Academy of Sciences. 26 (3): 178-181. ...
... is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants mainly ... "Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus". PLoS ONE. 10 (4): e0124595. doi: ...
Anthelmintics and their Uses in Medical and Veterinary Practice. The Williams & Wilkins Company. 1928. Chopra's Indigenous ...
All available anthelmintics are efficient at treating the infection. Prophylactic anthelmintic treatment may help prevent the ...
Then it is discovered that using any type of anthelmintic actually causes more excruciating pain and eventual death. Chaos ... Pharmacies are crowded with people desperate to get anthelmintics. Matters become worse when more people jump into rivers ...
Anthelmintics such as praziquantel may help prevent this condition. Prohibition of the feeding of uncooked offals may be the ...
Prevalence of anthelmintic resistance on 62 beef cattle farms in the North Island of New Zealand. NZ Vet J 546: 278-282. doi: ... Anthelmintic resistance in nematode parasites of cattle: a global issue? Trend Parasitol 27: 176-181. doi:10.1016/j.pt.2010.11. ... Anthelmintic resistance of Ostertagia ostertagi and Cooperia oncophora to macrocyclic lactones in cattle from the western ... Anthelmintic resistance in gastrointestinal nematodes of dairy cattle in the Macalister Irrigation District of Victoria. Aust ...
Paul, Arkajyoti; Adnan, Md.; & others (2018). "Anthelmintic activity of Piper sylvaticum Roxb. (family: Piperaceae): In vitro ...
The seeds are anthelmintic and carminative. The juice of the leaves is used as a remedy against discharge of pus from the ear. ...
... was marketed by Bayer as an anthelmintic in the early 20th century, and was featured in print ads alongside other ... In fact, large number of piperazine compounds have an anthelmintic action. Their mode of action is generally by paralysing ... These drugs are often referred to simply as "piperazine" which may cause confusion between the specific anthelmintic drugs, the ... Martin RJ (31 July 1997). "Modes of action of anthelmintic drugs". The Veterinary Journal. 154 (1): 11-34. doi:10.1016/S1090- ...
Artemisinin - shows anthelmintic activity[7]. Anthelmintic resistance[edit]. The ability of parasites to survive treatments ... Santonin, a historical anthelmintic no longer in use. References[edit]. *^ WHO (2006). Preventive chemotherapy in human ... Pills containing anthelmintics are used in mass deworming campaigns of school-aged children in many developing countries.[1][2] ... Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal ...
Anthelmintics. Class Summary. Parasite biochemical pathways are sufficiently different from the human host to allow selective ... The effectiveness of anthelmintic agents against larvae is poor; they are more effective once established infection occurs. ... Several anthelmintic drugs are available for established infection. Thiabendazole was a therapeutic option for strongyloidiasis ...
Anthelmintics. Class Summary. Parasite biochemical pathways are sufficiently different from the human host to allow selective ...
Make research projects and school reports about Anthelmintics easy with credible articles from our FREE, online encyclopedia ... Antihelminthic Drugs. Definition. Antihelminthic drugs are used to treat parasitic infestations.. Purpose. Parasitic ... Some antihelminthic drugs can pass into breast milk. Breastfeeding may have to be discontinued until the antihelminthic ... Some antihelminthic drugs work best when ingested along with fatty foods, such as milk or ice cream. Oral drugs should be taken ...
It is important to choose the most effective anthelmintic product to target the parasite(s) affecting your flock. In this video ... It is important to choose the most effective anthelmintic product to target the parasite(s) affecting your flock. In this video ... Why it is advised that you dont dose and move sheep - anthelmintics AHDB Beef & Lamb ...
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anthelmintic synonyms, anthelmintic pronunciation, anthelmintic translation, English dictionary definition of anthelmintic. ... anthelmintic. (ˌænθɛlˈmɪntɪk) , anthelminthic. or antihelminthic. n. (Pharmacology) med another name for vermifuge ... Anthelmintic - definition of anthelmintic by The Free Dictionary https://www.thefreedictionary.com/anthelmintic ... anthelmintic. Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia. ant·hel·min·tic. (ănt′hĕl-mĭn′tĭk, ăn′thĕl-) also ant ...
January 24, 2011. Use this list of as a reference when talking to your veterinarian about preventing common parasites from infecting your livestock.. ...
... killing or ejecting intestinal wormsOrigin of anthelmintic ant(i)- + Classical Greek helmins (gen. helminthos), worm + -ic an ... comparative more anthelmintic, superlative most anthelmintic). *(medicine) Destructive to parasitic intestinal worms.. Research ... Malefern, santonine, thymol and other anthelmintic remedies are prescribed.. *Its chief use is as an anthelmintic to destroy ... plural anthelmintics). *(medicine) A drug for the treatment of intestinal worm infestation, either by killing the worms or by ...
Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. We anticipate reposting the images once we are able identify and filter out images that do not match the information provided in the drug labels. ...
The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.. Chen M1, Wang J, Lu J, Bond MC, Ren XR, Lyerly HK, Barak LS ... We now report that the anti-helminthic niclosamide, a drug used for the treatment of tapeworm, promotes Frizzled1 endocytosis, ...
Learn about the veterinary topic of Combination Anthelmintics. Find specific details on this topic and related topics from the ... Also, combinations of anthelmintics are being used more and more. According to the recent guidelines of the World Association ... The wide use of anthelmintic combinations, often necessitated by the very high frequency of resistance to one or more available ... For example, derquantel (spiroindole class) has been approved for use in some countries as a combination anthelmintic product ...
Anthelmintics are commonly used to treat parasitic worm infections not only in animals, but humans as well. Resistance to ... Home / Shop / Books / Medicine and Health / Pharmacology / Anthelmintics: Clinical Pharmacology, Uses in Veterinary Medicine ... Chapter 2 - Anthelmintics: Clinical Pharmacology and Uses in Human and Veterinary Medicine (pp. 27-58). Ranjita Shegokar, Ph.D ... This books discusses topics such as the clinical pharmacology of anthelmintics; the uses in human and veterinary medicine; ...
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The objective of this study was to evaluate the anthelmintic activity... ... is used as anthelmintic in traditional system of medicine in Southern Punjab of Pakistan. ... Aswar M, Aswar U, Watkar B, Vyas M, Wagh A, Gujar KN (2008) Anthelmintic activity of Ficus benghalensis. Int J Green Phar 2(3): ... Tandon V, Pal P, Roy B, Rao HSP, Reddy KS (1997) In vitro anthelmintic activity of root-tuber extract of Flemingia vestita, an ...
What is Antihelminthic Drugs? Meaning of Antihelminthic Drugs medical term. What does Antihelminthic Drugs mean? ... Looking for online definition of Antihelminthic Drugs in the Medical Dictionary? Antihelminthic Drugs explanation free. ... Antihelminthic Drugs. Antihelminthic Drugs. Definition. Antihelminthic drugs are used to treat parasitic infestations. ... Some antihelminthic drugs can pass into breast milk. Breastfeeding may have to be discontinued until the antihelminthic ...
In their early beginnings it is probable that anthelmintics were first given consideration centuries ago when savages noticed ... The subject of anthelmintic medication underwent a very slow evolution up to less than a half century ago, at which time there ... The subject of anthelmintic medication underwent a very slow evolution up to less than a half century ago, at which time there ... In their early beginnings it is probable that anthelmintics were first given consideration centuries ago when savages noticed ...
Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma ... Comparative Evaluation of Anthelmintic Activity of Edible and Ornamental Pomegranate Ethanolic Extracts against Schistosoma ... J. de Moraes, A. A. C. Almeida, M. R. M. Brito et al., "Anthelmintic activity of the natural compound (+)-limonene epoxide ... M. A. Dkhil, "Anti-coccidial, anthelmintic and antioxidant activities of pomegranate (Punica granatum) peel extract," ...
Thus, tribendimidine may not be a viable anthelmintic where resistance to levamisole or pyrantel already exists but c … ... The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist PLoS Negl ... Although these parasites cause a tremendous disease burden, we have very few anthelmintic drugs with which to treat them. In ... Thus, tribendimidine may not be a viable anthelmintic where resistance to levamisole or pyrantel already exists but could ...
Thiabendazole-A New Anthelmintic Drug B. H. KEAN, M.D., F.A.C.P. ... Thiabendazole-A New Anthelmintic Drug. Ann Intern Med. 1967;67: ...
Anthelmintic Activity of Pyrantel Pamoate * Authors: Robert S. Desowitz, Theodore Bell, Joseph Williams*, Richard Cardines, ...
Chicken Meat with Anthelmintic Residue Found, Lawmaker Says. Egg layers Production types Flock management Biosecurity Food ... SOUTH KOREA - Some chicken meat has been found to carry more anthelmintic residue than the permissible level, an opposition ... two were found to contain the anthelmintic toltrazuril at concentrations of up to six times greater than the permissible level ...
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... wholesaling Anthelmintic Drug in India. Get Anthelmintic Drugs at best price from Anthelmintic Drugs Retailers, sellers, ... Find details of companies Supplying Anthelmintic Drugs, Manufacturing & ... We are offering anthelmintic drug. we are manufacturer & supplier of anthelmintic drug anthelmintic drug i-star more... ... Anthelmintics Drugs are formulated to treat infections with parasitic worms. These anthelmintics drugs should be taken by the ...
The Anti-helminthic Compound Mebendazole Has Multiple Antifungal Effects against Cryptococcus neoformans. Luna S. Joffe1, ... McKellar, Q. A., and Scott, E. W. (1990). The benzimidazole anthelmintic agents-a review. J. Vet. Pharmacol. Ther. 13, 223-247 ... The fact that the anti-helminthic compound had an additive effect to AmB also suggests that benzimidazole-like compounds could ... Gottschall, D. W., Theodorides, V. J., and Wang, R. (1990). The metabolism of benzimidazole anthelmintics. Parasitol. Today 6, ...
"Anthelmintics" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Anthelmintics" by people in this website by year, and whether ... Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. PLoS Negl Trop Dis. ... Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility. Proc Natl Acad Sci U S A. ...
Currently control of these diseases is heavily reliant on the use of broad spectrum anthelmintics; the benzimidazoles (BZ; ... suggests that the intensive use of anthelmintics is not a sustainable approach. ... of diagnosis and develop effective management strategies that can be used to conserve the efficacy of our current anthelmintic ...
Genetic Analysis of Biosynthesis of Polyketide Anthelmintic Macrolide Avermectin in Streptomyces avermitilis * * Ikeda Haruo ... Avermectins, new family of potent anthelmintic agents : efficacy of the Bla component EGERTON J. R. ... Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin Streptomyces avermitils., ...
  • Three primary areas of concern are apparent with fixed-dose commercial anthelmintic combination products, viz, drug-drug interactions (safety and efficacy implications of pharmacokinetics and pharmacodynamics), common mechanisms of resistance, and best-practice management to ensure appropriate use for sustainability of parasite control with the products. (merckvetmanual.com)
  • The aims of this research is to provide improved means of diagnosis and develop effective management strategies that can be used to conserve the efficacy of our current anthelmintic families. (moredun.org.uk)
  • Factors affecting the anthelmintic efficacy of papaya latex in vivo: host sex and intensity of infection. (cambridge.org)
  • Licking behaviour induces partial anthelmintic efficacy of ivermectin pour-on formulation in untreated cattle. (archives-ouvertes.fr)
  • However, its impact on anthelmintic efficacy remains to be established. (archives-ouvertes.fr)
  • Anthelmintic efficacy, expressed as an average reduction of the FECs over the experimental period, was maximal in the treated group. (archives-ouvertes.fr)
  • The use of a classical pharmacodynamic model demonstrated a clear relationship between exposure and efficacy and enabled us to define the critical plasma or faecal ivermectin concentrations delimiting an exposure window associated with partial anthelmintic efficacy. (archives-ouvertes.fr)
  • Finally, our results show that macrocyclic lactone exchange between cattle after pour-on administration, resulting from natural grooming behaviour, can significantly impact on anthelmintic efficacy. (archives-ouvertes.fr)
  • This raises several issues such as the design of comparative clinical trials and the occurrence of partial efficacy which is considered a risk factor for the development of anthelmintic resistance. (archives-ouvertes.fr)
  • Introduction: A study on the current status of parasitic intestinal helminthes and the efficacy of anthelmintic drug was carried out among primary school pupils at Community Primary School Ogurugu, Uzo-Uwani Local Government Area, Enugu State. (scirp.org)
  • Objectives: The research was conducted in order to determine the prevalence of human intestinal helminthes among primary school pupils, and also to determine the prevalence in relation to age and sex, and to check the efficacy of anthelmintic drug (Levamisole) on the worms, in Ogurugu Uzo-Uwani Local Government Area, Enugu State, Nigeria. (scirp.org)
  • Results: Data obtained showed an overall prevalence of 143 (59.1%) out of 242 samples and that the efficacy of anthelmintic drug Ergamisole? (scirp.org)
  • Age related prevalence and efficacy of anthelmintic varied across the sample groups. (scirp.org)
  • C. Ukwubile, O. Otalu Jr., U. Akpabio and M. Agu, "The Prevalence of Parasitic Human Intestinal Helminthes and the Efficacy of Anthelmintic Drug in Children in Uzo-Uwani Local Government Area, Enugu State, Nigeria," Open Journal of Medical Microbiology , Vol. 3 No. 4, 2013, pp. 213-218. (scirp.org)
  • In the herds belonging to twelve smallholder sheep farmers, the efficacies of albendazole, levamisole and closantel were tested by faecal egg count reduction tests where 80 % efficacy was considered the cut off for anthelmintic resistance. (scielo.org.za)
  • The Faecal Egg Count Reduction Test (FECRT) is the most widely used field-based method for estimating anthelmintic efficacy and as an indicator of the presence of anthelmintic resistant nematodes in cattle, despite never having been validated against the gold standard of controlled slaughter studies. (strath.ac.uk)
  • The objectives of this study were to assess the normality of cattle faecal egg count (FEC) data and their transformed versions, since confidence intervals used to aid the interpretation of the FECRT, are derived from data assumed to be normally distributed, and violation of this assumption could potentially lead to the misclassification of anthelmintic efficacy. (strath.ac.uk)
  • otherwise apparent anthelmintic efficacy could be misrepresented. (strath.ac.uk)
  • Practitioners can utilize the Fecal Egg Count Reduction Test to detect anthelmintic resistance in Parascaris , and the same technique can be applied regularly to confirm the continued efficacy of those drugs currently in use. (biomedcentral.com)
  • Worm control practices were gauged by means of a questionnaire, and the Faecal Egg Count Reduction Test was performed for assessing anthelmintic efficacy of albendazole, levamisole and ivermectin. (up.ac.za)
  • Emodepside) - effective against a variety of gastrointestinal helminths Monepantel (aminoacetonitrile class) - effective against a variety of nematodes including those resistant to other anthelmintic classes Spiroindoles (e.g. derquantel) - effective against a variety of nematodes including those resistant to other anthelmintic classes Artemisinin - shows anthelmintic activity Anthelmintic resistance in parasites is now widespread. (wikipedia.org)
  • An extensive comparison of the effect of anthelmintic classes on diverse nematodes. (umassmed.edu)
  • Giovanelli F, Mattellini M, Fichi G, Flamini G, Perrucci S. In Vitro Anthelmintic Activity of Four Plant-Derived Compounds against Sheep Gastrointestinal Nematodes. (mdpi.com)
  • These results revealed that pumpkin seed has high anthelmintic activity against nematodes as well as its continued use in traditional medicine for the treatment of helminthiasis. (academicjournals.org)
  • This has led to the investigation of alternative methods to manage nematodes, including the use of plants and plant extracts as a potential source of novel anthelmintics. (csir.co.za)
  • On the premise that C. elegans is a 'model nematode' with respect to many aspects of neural function, the intention is that this might inform a broader understanding of the role of these channels in the nematodes and their potential as novel anthelmintic targets. (soton.ac.uk)
  • A survey was conducted on the occurrence of anthelmintic resistance of nematodes in communally grazed sheep in a semi-arid area near Mafikeng South Africa, from January to March 2006. (scielo.org.za)
  • 2. Bakunzi F R 2003 Anthelmintic resistance of nematodes in communally grazed goats in a semi-arid area of South Africa. (scielo.org.za)
  • 3. Besier R B, Love S C J 2003 Anthelmintic resistance in sheep nematodes in Australia: the need for new approaches. (scielo.org.za)
  • Importantly, most commercially available anthelmintics have become increasingly ineffective because of growing resistance (benzimidazoles, levamisole and, most recently, ivermectin) and most nematicides (DCBP (1,2-dibromo-3-chloropropane), methyl bromide), to control plant nematodes, have been banned by the EPA because of human toxicity [ 8 - 13 ]. (prolekare.cz)
  • While surveys in Southern Africa indicate anthelmintic resistance of gastrointestinal nematodes to be common in small ruminants in South Africa, Kenya and Zimbabwe, there have been no reports of resistance in Zambia. (up.ac.za)
  • Albendazole is an anthelmintic or anti-worm medication. (thefreedictionary.com)
  • Comparative studies of the anthelmintic activities of albendazole and test durgs 1 and 2 in housefly worms and earthworms. (hindawi.com)
  • Albendazole has become the anthelmintic of choice and offers good CSF penetration. (thefreedictionary.com)
  • After every episode she was given antihelminthic drugs like albendazole and mebendazole by physician. (thefreedictionary.com)
  • We studied drug combination effects using the main standard anthelmintics, albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin in the Trichuris muris model. (biomedcentral.com)
  • The aim of the present study was to analyze drug combination effects using the main standard anthelmintics albendazole, mebendazole, levamisole, pyrantel pamoate and ivermectin in the T. muris mouse model. (biomedcentral.com)
  • The global Albendazole Anthelmintic Drug market size is expected to gain market growth in the forecast period of 2020 to 2025, with a CAGR of xx%% in the forecast period of 2020 to 2025 and will expected to reach USD xx million by 2025, from USD xx million in 2019. (marketsandresearch.biz)
  • Albendazole Anthelmintic Drug market is split by Type and by Application. (marketsandresearch.biz)
  • Regional analysis is another highly comprehensive part of the research and analysis study of the global Albendazole Anthelmintic Drug market presented in the report. (marketsandresearch.biz)
  • This section sheds light on the sales growth of different regional and country-level Albendazole Anthelmintic Drug markets. (marketsandresearch.biz)
  • For the historical and forecast period 2015 to 2025, it provides detailed and accurate country-wise volume analysis and region-wise market size analysis of the global Albendazole Anthelmintic Drug market. (marketsandresearch.biz)
  • For the period 2015-2020, this study provides the Albendazole Anthelmintic Drug sales, revenue and market share for each player covered in this report. (marketsandresearch.biz)
  • Among other players domestic and global, Albendazole Anthelmintic Drug market share data is available for global, North America, Europe, Asia-Pacific, Middle East and Africa and South America separately. (marketsandresearch.biz)
  • Chapter 1, to describe Albendazole Anthelmintic Drug product scope, market overview, market opportunities, market driving force and market risks. (marketsandresearch.biz)
  • Chapter 2, to profile the top manufacturers of Albendazole Anthelmintic Drug, with price, sales, revenue and global market share of Albendazole Anthelmintic Drug in 2018 and 2019. (marketsandresearch.biz)
  • Chapter 3, the Albendazole Anthelmintic Drug competitive situation, sales, revenue and global market share of top manufacturers are analyzed emphatically by landscape contrast. (marketsandresearch.biz)
  • Chapter 4, the Albendazole Anthelmintic Drug breakdown data are shown at the regional level, to show the sales, revenue and growth by regions, from 2015 to 2020. (marketsandresearch.biz)
  • Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms ( helminths ) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. (wikipedia.org)
  • Treatment with an antihelminthic drug kills worms whose phenotype renders them susceptible to the drug, but resistant parasites survive and pass on their "resistance" genes. (wikipedia.org)
  • Other antihelminthic drugs, such as diethylcarbamazepine citrate (Hetrezan), used for treatment of roundworms and other parasites, is supplied directly by its manufacturer when needed. (encyclopedia.com)
  • Most antihelminthic drugs are only active against specific parasites, some are also toxic. (encyclopedia.com)
  • Unfortunately, by following these practices, we've unwittingly exposed our livestock's parasites to every single class of anthelmintic (dewormer) year-round. (thefreedictionary.com)
  • Although these parasites cause a tremendous disease burden, we have very few anthelmintic drugs with which to treat them. (nih.gov)
  • The Anti Anthelmintic Medicine We Provide is Indicated At the Time of Single or Mixed Intestinal Parasites. (exportersindia.com)
  • The emergence of parasites that are resistant to some or all of these compounds however, suggests that the intensive use of anthelmintics is not a sustainable approach. (moredun.org.uk)
  • Because some parasites have the ability to produce ATP under anaerobic conditions through specific metabolic pathways, these mechanisms have often been the target of anthelmintics. (frontiersin.org)
  • However, the use of anthelmintics (drug class which eliminates parasites) should not be done indiscriminately. (omegafields.com)
  • A growing concern within the equine industry is the international development of anthelmintic resistance among the common parasites which infest horses. (omegafields.com)
  • In a recent issue of Veterinary Parisitology looking at anthelmintic resistance of horses in Finland, treatment of infected horses with ivermectin only resulted in a 52% decrease in the number of eggs found in the feces and 63% of horses had resistant parasites. (omegafields.com)
  • 6. Chandrawathani P, Yusoff N, Wan L C, Ham A, Waller P J 2004 Total anthelmintic failure to control nematode parasites of small ruminants on government breeding farms in Sabah East Malaysia. (scielo.org.za)
  • The action of anthelmintics on parasites located outside of the alimentary canal / by Brayton Howard Ransom, Chief of the Zoological Division and Maurice C. Hall, assistant zoologist, Zoological Division. (in.us)
  • Anthelmintic resistance in parasites of horses was first reported approximately five decades ago when various researchers noted that phenothiazine treatment failed to reduce strongylid egg counts [ 1 - 3 ]. (biomedcentral.com)
  • Deworming (sometimes known as worming , drenching or "dehelmintization") is the giving of an anthelmintic drug (a wormer , dewormer , or drench ) to a human or animal to rid them of helminths parasites , such as roundworm , flukes and tapeworm . (wikipedia.org)
  • Anthelmintics are drugs that act against internal parasites of animals such as tapeworms, liver flukes, and round worms. (randoxfooddiagnostics.com)
  • Several anthelmintic drugs are available for established infection. (medscape.com)
  • Antihelminthic drugs are used to treat parasitic infestations. (encyclopedia.com)
  • Antihelminthic drugs are prescribed to treat these infestations. (encyclopedia.com)
  • Antihelminthic drugs are available only with a prescription and are available as liquids, tablets or capsules. (encyclopedia.com)
  • Some types of parasitic infestations are rarely seen in the United States , thus, the corresponding antihelminthic drugs are not widely distributed and need to be obtained fromt he United States Center for Disease Control (CDC) when required. (encyclopedia.com)
  • Antihelminthic drugs must be taken exactly as directed to completely rid the body of the parasitic infestation, and for as long as directed. (encyclopedia.com)
  • Some antihelminthic drugs work best when ingested along with fatty foods, such as milk or ice cream. (encyclopedia.com)
  • Some antihelminthic drugs, such as praziquantel, come in chewable form. (encyclopedia.com)
  • Antihelminthic drugs sometimes need to be taken with other medications. (encyclopedia.com)
  • We are reckoned as one of the eminent Anthelmintic Drugs Manufacturers. (exportersindia.com)
  • Anthelmintics Drugs are formulated to treat infections with parasitic worms. (exportersindia.com)
  • These anthelmintics drugs should be taken by the direction of the physician and in correct dosage for effective results. (exportersindia.com)
  • We are a well-recognized name as Anthelmintic Drugs Anthelmintic Drugs Manufacturer and Supplier in Dehradun, Uttarakhand. (exportersindia.com)
  • The Anthelmintic Drugs that we provide are formulated under the supervision of experts. (exportersindia.com)
  • We are offering anthelmintic drugs. (exportersindia.com)
  • We studied the anthelmintic activities of various drugs on housefly worms and earthworms. (hindawi.com)
  • To control this parasite effectively, the anthelmintic properties of several extracts obtained from Euphorbia fischeriana and four common anthelmintic drugs (trichlorfon, praziquantel, 40 per cent phoxim and mebendazole) against adults and eggs of D. vastator were assessed in vitro and in vivo . (thefishsite.com)
  • Furthermore, emerging evidence indicates that these channels are key mediators of a number of neuroactive drugs, including the most recent new anthelmintic, the cyclo-octadepsipeptide emodepside. (soton.ac.uk)
  • The inclusion criteria were not pregnant patients, non-medicated with any of antihelminthic drugs , non-medicated with any of antibiotic, phenytoin, carbamazepine, no complication of gastrointestinal symptoms, no hepatitis or liver diseases. (thefreedictionary.com)
  • Nevertheless, continued efforts can be made to standardize the plant extracts with good anthelmintic activity and formulate best alternative herbal preparations to replace or complement the synthetic drugs, which are currently in use. (scirp.org)
  • In the face of macrocyclic lactone resistance, piperazine or anthelmintics of the benzimidazole or pyrimidine classes can be used to control ascarid infections, but Parascaris populations that are concurrently resistant to macrocyclic lactones and pyrimidine drugs have been reported recently from Texas and Kentucky. (biomedcentral.com)
  • Frequency of treatment varied from twice a year to every 6 weeks and drugs of different anthelmintic groups were alternated within the same year. (up.ac.za)
  • Anthelmintic drugs for poultry. (malaimare.ro)
  • Help boxes and practical tips are included throughout alongside a wealth of colour photographs, drawings and life-cycle anthelmintic drugs for poultry. (malaimare.ro)
  • Key features include: An easy to navigate textbook, providing information essential for clinical studies Full colour throughout, with photographs, diagrams, life-cycles and help boxes for anthelmintic drugs for poultry learners A companion website including a pronunciation guide, self-assessment questions and further reading lists. (malaimare.ro)
  • Evaluation of anthelmintic activity of any drug when carried out in laboratory conditions by using the isolated worms from nature cannot be adaptable with artificial laboratory conditions. (hindawi.com)
  • Therefore, the present study aims at developing a new adaptable method for evaluation of anthelmintic activity. (hindawi.com)
  • The development of anthelmintic resistance was virtually inevitable, given certain biological features of Parascaris and unique pharmacologic characteristics of the macrocyclic lactones. (biomedcentral.com)
  • Agaie BM, Onyeyili PA (2007) Anthelmintic activity of the crude aqueous leaf extracts of Anogeissus leiocarpus in sheep. (springer.com)
  • Anthelmintic activity of Leucaena leucocephala protein extracts on Haemonchus contortus. (cambridge.org)
  • The present study describes the proximate composition, antifungal and anthelmintic activity of solvent extracts of the macrolichen R. (thefreedictionary.com)
  • These extracts were further used to find out the antimicrobial, antioxidant and anthelmintic activities. (scirp.org)
  • Acetone extracts were prepared from 15 South African plant species and their anthelmintic activity determined using the egg hatch assay (EHA). (csir.co.za)
  • The extracts exhibited anthelmintic ac-tivity and thus could be an inexpensive and readily available source of anthelmintic treatment. (ajol.info)
  • This study was undertaken to investigate the anthelmintic activity of Lophira lanceolata on the cattle parasite Onchocerca ochengi and the anthelmintic drug resistant strains of the free living nematode Caenorhabditis elegans and to determine the phytochemical profiles of the extracts and fractions of the plants. (biomedcentral.com)
  • Ethanolic and methanolic-methylene chloride crude extracts and fractions of L. lanceolata showed in vitro anthelmintic activity. (biomedcentral.com)
  • The in vitro anthelmintic evaluation of the crude extracts and solvent partitions on Pheretima posthuma and Ascarissuum (eggs and L2 stage) respectively showed significant results at the same concentration (10, 20, 40 and 80 mg/ml). (scirp.org)
  • The effectiveness of mebendazole as an anthelmintic was evaluated at three concentrations: 120 mg/L, 160 mg/L, and 200 mg/L. (thefreedictionary.com)
  • This range of ivermectin plasma concentrations (0.1-1 ng/mL) could be considered as a potential selection window for anthelmintic resistance. (archives-ouvertes.fr)
  • In the latter case drenching with ivermectin was well interspersed with that of other anthelmintics. (up.ac.za)
  • This rapid development of resistance suggests that there may be cross-resistance between ivermectin and another anthelmintic group. (up.ac.za)
  • Two of the ivermectin resistant strains were recovered from separate properties in the south-western Cape Province, where Ostertagia circumcincta, which is usually the dominant parasite in this region, was virtually eliminated by the anthelmintic treatment. (up.ac.za)
  • Anthelmintics are used to treat people who are infected by helminths, a condition called helminthiasis . (wikipedia.org)
  • Anthelmintics expel helminths from the patient's body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). (thefreedictionary.com)
  • Anthelmintics are also used to kill helminths. (thefreedictionary.com)
  • How do we deal with anthelmintic resistance of herbivore helminths? (scielo.org.za)
  • During the past decade in South Africa there has been a continual increase in sheep of strains of gastrointestinal helminths resistant to the modern anthelmintics. (up.ac.za)
  • The benzimidazole anthelmintics--chemistry and biological activity. (nih.gov)
  • 9. Ndamukong K J N, Sewell M M H,1992 Resistance to benzimidazole anthelmintics by trichostrongyles in sheep and goats in North West Cameroon. (scielo.org.za)
  • In cattle, prevalence of anthelminthic resistance varied between anthelmintic classes from 0-100% (benzimidazoles and macrocyclic lactones), 0-17% (levamisole) and 0-73% (moxidectin), and both Cooperia and Ostertagia survived treatment. (wikipedia.org)
  • It is important to choose the most effective anthelmintic product to target the parasite(s) affecting your flock. (youtube.com)
  • ZnO NPs at environmentally relevant concentrations achieved a significant antihelminthic activity against P. equorum which represents a successful model used in parasite control experiments. (springer.com)
  • Thus, tribendimidine may not be a viable anthelmintic where resistance to levamisole or pyrantel already exists but could productively be used where resistance to benzimidazoles exists or could be combined with this class of anthelmintics. (nih.gov)
  • One of these strains was concurrently resistant to 3 different anthelmintic groups, namely, the ivermectins, the benzimidazoles and the salicylanilides. (up.ac.za)
  • Methods: A double-blind placebo-controlled randomised trial was conducted to investigate the impact of anthelmintic treatment on Plasmodium infection in children aged 12-59 months. (tcd.ie)
  • The objective of this study was to evaluate the anthelmintic activity of the methanol extract of B. malabaricum leaves (MEBM). (springer.com)
  • Therefore, culturing of housefly worms was carried out to evaluate the anthelmintic activity and found an easy, prominent, eco-friendly, and reproducible method in all aspects such as equal age, size, and weight of worms used for the experiment. (hindawi.com)
  • The method developed shows easy analysis with worms equal in age, size, weight, and adaptable environment, which has been taken to evaluate the anthelmintic activity with housefly worms. (hindawi.com)
  • The study established the anthelmintic activity of MEBM. (springer.com)
  • Balamurugan G, Selvarajan S (2009) Preliminary phytochemical screening and anthelmintic activity of Indigofera tinctoria Linn. (springer.com)
  • Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum. (umassmed.edu)
  • Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual Anthelmintic Activity against Schistosoma mansoni and Trichuris muris. (cambridge.org)
  • The present anthelmintic activity study reveals a new methodology with housefly worms cultured in laboratory conditions that resemble parasitic pinworms found in human being. (hindawi.com)
  • Evaluations of anthelmintic activity of any drug when carried out in artificial laboratory conditions by using the earthworms ( Lumbricus terrestris) , isolated intestinal worms (from animals) and isolated Ascaris lumbricoides from stools (human) cannot be adaptable with artificial laboratory conditions, as reported previously [ 6 ]. (hindawi.com)
  • So the objective of the present anthelmintic activity study reveals a new methodology with housefly worms in laboratory conditions that resemble pinworms in human infections. (hindawi.com)
  • Pyrvinium pamoate (PP) is an FDA-approved classical anthelmintic, but is now attracting particular attention as an anti-cancer drug after recent findings of its potent cytotoxicity against various cancer cell lines only during glucose starvation, as well as its anti-tumor activity against hypovascular pancreatic cancer cells transplanted in mice. (frontiersin.org)
  • However, it is not known whether all samples of the pink and blue ginger in each region in Indonesia have the same potential and activity as anthelmintic. (ipb.ac.id)
  • Then the analysis of anthelmintic activity was done towards all samples from those five regions. (ipb.ac.id)
  • These compounds play a role in the activity of the pink and blue ginger as anthelmintic. (ipb.ac.id)
  • Synthesis, anthelmintic and antiacetylcholinesterase activity of newer furan derivatives. (ijpsonline.com)
  • The compounds were screened for acetylcholinesterase inhibitory activity as well as the anthelmintic activity against H. nana. (ijpsonline.com)
  • The anthelmintic effect of tolzan is more on the acid phosphatase activity than the alkaline phosphatase activity in Pallisentis nagpurensis. (thefreedictionary.com)
  • Anthelmintic Activity of a Polyherbal Preparation" by A. Dwivedi, S. Dwivedi et al. (siu.edu)
  • The present study was done with the aim to investigate the anthelmintic activity of polyherbal formulation containing herbs Thespesia populnea (bark), Terminalia alata (bark), Clematis triloba (roots) and Ceratophyllum demersum (leaves) using adult earthworm Pheritima posthuma. (siu.edu)
  • The aim of this study is to investigate the antihelminthic activity of Alstonia boonei De Wild (Apocynaceae) and Vernonia amygdalina (Asteraceae) using earth-worms ( Lumbricus terretris ). (ajol.info)
  • Compounds 5, 8 and 12 were found to exhibit potent anthelmintic activity against M. konkanensis, P. corethruses and Eudrilus sp. (ajol.info)
  • In vitro investigation of anthelmintic activity of Mitragyna parvifolia (Roxb. (scopemed.org)
  • In the present study anthelmintic activity of Mitragyna parvifolia (Roxb. (scopemed.org)
  • MGG, x The immunocytomarking was proven to be inconclusive detoxifierea corpului acasa the final anthelmintic activity of azadirachta indica a suspicion of pleural carcinoma or mesothelioma because the material of the smear presented a dense film of an eosinophilic material proteins. (autosuprem.ro)
  • In the case of the draw that came from the pleural effusion colored using MGG there can be observed a background of the smear that consists of a light granullar proteic material and a slight blood contamination, without any signs of erytrophagocytosis or anthelmintic activity of azadirachta indica. (autosuprem.ro)
  • The cytological anthelmintic activity of azadirachta indica is compatible to a modified transsudate or a starting chilothorax Fig. (autosuprem.ro)
  • MGG, x 24 Lucrări Ştiinţifice - anthelmintic activity of azadirachta indica. (autosuprem.ro)
  • In the case of the anthelmintic activity of azadirachta indica draws that were cytologically examined, there was not possible to identify the origin of tumoral cells because of the morphologic changes that they had suffered. (autosuprem.ro)
  • Microfluidic platform for electrophysiological recordings from host-stage hookworm and Ascaris suum larvae: A new tool for anthelmintic research. (umassmed.edu)
  • Although still only theoretical, changes in the immunogenicity of ascarid isolates or reduction of their prepatent or egg reappearance periods could pose far greater challenges to effective control than resistance to a single class of anthelmintics. (biomedcentral.com)
  • The key ingredient in Reese's Pinworm Medicine is pyrantel pamoate, which is the only anthelmintic drug that has been approved for O-T-C sales by the Food and Drug Administration. (thefreedictionary.com)
  • The worldwide increased difficulty to combat gastrointestinal nematode (GIN) infection in sheep, due to progressing anthelmintic resistance (AR), calls for an enhanced and standardized implementation of early detection of AR. (nih.gov)
  • Dosage is established depending on the patient's general health status and age, the type of antihelminthic drug used, and the type of parasitic infestation being treated. (encyclopedia.com)
  • For example, steroids such as prednisone are also prescribed together with the antihelminthic drug for tapeworm to reduce the inflammation that the worm may cause. (encyclopedia.com)
  • According to The Korea Herald , citing data from the Ministry of Food and Drug Safety, Hwang Ju-hong of the People's Party said that of 60 chicken products examined from April to May, two were found to contain the anthelmintic toltrazuril at concentrations of up to six times greater than the permissible level of 0.1 milligram per kilogram. (thepoultrysite.com)
  • We are offering anthelmintic drug. (exportersindia.com)
  • Unibios laboratories limited - we take pleasure in introducing ourselves as a renowned manufacturer and supplier of a wide variety of anthelmintic drug in india. (exportersindia.com)
  • We here report that the FDA-approved anthelmintic drug nitazoxanide could be a potential candidate for advancement into cancer clinical trials. (aacrjournals.org)
  • They are controlled by anthelmintics, but these are losing their effectiveness as a result of the emergence of drug-resistant strains of worm ( Gilleard, 2006 ). (aspetjournals.org)
  • Professor Karl Hoffmann of Aberystwyth University was introduced by LSTM's Head of Parasitology Professor Mark Taylor to an audience of over 30 members of LSTM staff and students, and gave a seminar entitled Aberystwyth Anthelmintic Drug Discovery: Seven years of steady progress . (lstmed.ac.uk)
  • The factors influencing significantly on the reduction of the faecal egg count after a single anthelmintic treatment were the type of herd, the age of the horse, the drug used, and the anthelmintic-resistance-status of the herd. (dtu.dk)
  • Barbora Szotakova, Milan Nobilis, Jiri Lamka, Veronika Krizova, Michal Savlik and Lenka Skalova, " Modulation of Porcine (Sus scrofa domestica) and Pheasant (Phasianus colchicus) Carbonyl Reducing Enzymes by Anthelmintic Therapy with Flubendazole", Drug Metabolism Letters (2008) 2: 29. (eurekaselect.com)
  • Emodepside is a resistance-breaking anthelmintic of a new chemical class, the cyclooctadepsipeptides. (aspetjournals.org)
  • The aim of this study was to investigate the anthelmintic effect of pumpkin seeds ( Cucurbita maxima ) against Aspiculuris tetraptera in naturally infected mice. (academicjournals.org)
  • Ever since the advent of broad-spectrum anthelmintics in the 1960s, anthelmintics of the macrocyclic lactone family have a significantly longer residual effect in comparison with the other anthelmintics. (scirp.org)
  • Over time, questions have been raised concerning the long-term impact of the massive application of these highly efficacious, broad-spectrum anthelmintic compounds on the environment. (scirp.org)
  • Valbazen is a broad-spectrum anthelmintic effective in the removal and control of liver flukes, tapeworms, stomach worms (including 4th stage inhibited larvae of Ostertagia ostertagi), intestinal. (vetprovisions.com)
  • 14. Van Wyk J A, Malan F S, Gerber H M, Alves R M R 1989 The problem of escalating resistance of Haemonchus contortus to the modern anthelmintics in South Africa. (scielo.org.za)
  • Oral dosing with papaya latex is an effective anthelmintic treatment for sheep infected with Haemonchus contortus. (sigmaaldrich.com)
  • The action of different anthelmintics varies. (thefreedictionary.com)
  • Indeed, to date, limited research has been done to assess whether combinations of different anthelmintics produce synergistic effects. (biomedcentral.com)
  • The development of resistance to available anthelmintics coupled with their high cost has further complicated matters. (csir.co.za)
  • Few field studies focus on anthelmintic treatment of definitive hosts. (cdc.gov)
  • 5) Treatment is difficult, combining careful surgical removal of cysts and anthelmintic therapy, (6) but is usually successful for infections occurring in Canada. (thefreedictionary.com)
  • Compared to traditional practices, future recommendations for ascarid control should feature: 1) use of only those anthelmintics known to be effective against indigenous populations, 2) initiation of anthelmintic treatment no earlier than 60 days of age, and 3) repetition of treatments at the longest intervals which prevent serious environmental contamination with Parascaris eggs. (biomedcentral.com)
  • 200 eggs per gram faeces) 903 horses were sampled and the analysis of the efficiency of a single anthelmintic treatment was based on 605 horses. (dtu.dk)
  • The following factors had a significant effect on the endoparasitic burden: herd type, age of the horses, use of pasture rotation, anthelmintic treatment of horses visiting the herd, use of an adviser in the planning of endoparasite control and advice regarding pasture rotation. (dtu.dk)
  • If pasture hygiene was performed on the advice of the veterinarian, the effect of a single anthelmintic treatment was less compared to a single anthelmintic treatment without any advice. (dtu.dk)
  • Bjørn, H. / Risk factors for high endoparasitic burden and the efficiency of a single anthelmintic treatment of Danish horses . (dtu.dk)
  • On all farms, anthelmintic treatment was the only approach used to control nematode infections. (up.ac.za)
  • Oil of turpentine (Oleum terebinthinae) is administered internally as an anthelmintic to kill tapeworm. (yourdictionary.com)
  • 12. Van Wyk J A, Stenson M O, Van der Merwe J S, Vorster R J, Viljoen P G 1999 Anthelmintic resistance in South Africa: surveys indicate an extremely serious situation in sheep and goat farming. (scielo.org.za)
  • Anthelmintics are commonly used to treat parasitic worm infections not only in animals, but humans as well. (novapublishers.com)
  • Anthelmintics are essential for worm control and, to avoid anthelmintic resistance developing through frequent use and mis-use, a strategy must be developed. (thefreedictionary.com)
  • a parsimonious explanation of emodepside's anthelmintic action is that it activates a SLO-1-dependent pathway to bring about neuromuscular inhibition and paralysis of the pathways that regulate feeding, locomotion, and egg-laying in the worm. (aspetjournals.org)
  • A serious threat to control is the dissemination of worm strains with multiple resistance to anthelmintics. (up.ac.za)
  • Mechanistic and single-dose in vivo therapeutic studies of Cry5B anthelmintic action against hookworms. (umassmed.edu)
  • Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo. (cambridge.org)
  • In the anthelmintic cyclooctadepsipeptide PF1022A (1) didepsipeptide units have been exchanged for the beta-turn mimetics (D)-Pro-(L)-Pro and BTD (7) in order to elucidate the functional role of the depsipeptide backbone. (mysciencework.com)
  • The occurrence of anthelmintic resistance in this farming sector is of concern and steps should be taken to prevent its further spread and development to avoid a situation developing as on numerous commercial sheep farms in South Africa where resistance is common. (scielo.org.za)
  • 11. Tsholofero B M, Bakunzi F R 2002 Anthelmintic resistance in communally grazed sheep in Northwest Province, South Africa. (scielo.org.za)
  • The present study was undertaken to assess the biochemical changes in goats treated with anthelmintic indigenous herbs. (scopemed.org)
  • Yet, most concerns that parasitologists and equine practitioners harbored about anthelmintic-resistant cyathostomins were mitigated by the fact that small strongyles are generally not serious pathogens in well-managed horses. (biomedcentral.com)
  • Horse owners and equine practitioners are now aware of anthelmintic-resistance in ascarids, and have numerous practical questions regarding its detection, management, and prevention. (biomedcentral.com)
  • Importantly, each of these anthelmintics is active in the free-living nematode, Caenorhabditis elegans and our understanding of their modes of action has, in large part, resulted from our ability to genetically manipulate their putative targets in receptive C . elegans mutant backgrounds [ 18 - 21 ]. (prolekare.cz)
  • Discovery of a highly synergistic anthelmintic combination that shows mutual hypersusceptibility. (umassmed.edu)
  • In vitro all 10 combinations of the standard anthelmintics tested against T. muris revealed synergistic behavior. (biomedcentral.com)
  • Professor Jacqui Matthews, from the Moredun said: "The test fills an important gap in our diagnostic toolbox and will enable horse owners to work with their veterinarians in targeting anthelmintic treatments against cyathostomin infections and hence help protect these important medicines for the future. (thefreedictionary.com)
  • Exploration of Ethnopharmacological Potential of Antimicrobial, Antioxidant, Anthelmintic and Phytochemical Analysis of Medicinally Important Plant Centella asiatica (L.) Urban in Mart. (scirp.org)
  • Given the prevalence of helminth infections, it is important to consider the advantages and disadvantages of antihelminthic interventions in community-based distribution (CBD) family planning programs. (taylorfrancis.com)