A neurosurgical procedure that removes the anterior TEMPORAL LOBE including the medial temporal structures of CEREBRAL CORTEX; AMYGDALA; HIPPOCAMPUS; and the adjacent PARAHIPPOCAMPAL GYRUS. This procedure is generally used for the treatment of intractable temporal epilepsy (EPILEPSY, TEMPORAL LOBE).
Treatment of chronic, severe and intractable psychiatric disorders by surgical removal or interruption of certain areas or pathways in the brain, especially in the prefrontal lobes.
A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
A neurobehavioral syndrome associated with bilateral medial temporal lobe dysfunction. Clinical manifestations include oral exploratory behavior; tactile exploratory behavior; hypersexuality; BULIMIA; MEMORY DISORDERS; placidity; and an inability to recognize objects or faces. This disorder may result from a variety of conditions, including CRANIOCEREBRAL TRAUMA; infections; ALZHEIMER DISEASE; PICK DISEASE OF THE BRAIN; and CEREBROVASCULAR DISORDERS.
A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The excision of lung tissue including partial or total lung lobectomy.
Cognitive disorders including delirium, dementia, and other cognitive disorders. These may be the result of substance use, trauma, or other causes.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
Dominance of one cerebral hemisphere over the other in cerebral functions.
A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.
Endoscopic surgery of the pleural cavity performed with visualization via video transmission.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Surgery performed on the nervous system or its parts.
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
The ability to learn and to deal with new situations and to deal effectively with tasks involving abstractions.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The period following a surgical operation.
Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.

Detection of visual field defects in patients after anterior temporal lobectomy for mesial temporal sclerosis-establishing eligibility to drive. (1/100)

AIMS: The aim of this study is to quantify visual field defects after temporal lobectomy for mesial temporal sclerosis and to establish eligibility for driving. METHODS: Automated static perimetry was performed on 14 patients who had undergone anterior temporal lobectomy for mesial temporal sclerosis. Perimetry consisted of monocular Humphrey Field Analyser (HFA) 30-2 test and a binocular Esterman 120 test. RESULTS: Of the 14 patients, three had no loss or non-specific loss, eight had partial homonymous quadrantanopia, one had complete homonymous quadrantanopia and two had concentric loss attributable to vigabatrin, which may have masked any loss occurring due to surgery. Of these, only seven passed the standardised DVLA visual fields. Of the seven who failed DVLA visual field, one had complete quadrantanopia, four had partial quadrantanopia and two had concentric loss (due to vigabatrin). CONCLUSIONS: Visual field defects contribute a great deal in the reduction of the quality of life in patients who have had surgery for mesial temporal sclerosis. Potential surgically induced visual field defects that could preclude driving need to be discussed with each patient preoperatively. In our study 50% of patients did not meet the required DVLA standards.  (+info)

Emotional facial paresis in temporal lobe epilepsy: its prevalence and lateralizing value. (2/100)

The selection of patients with medically refractory temporal lobe epilepsy (TLE) for surgery depends on the concordance of data from clinical, imaging and electroencephalographic evaluation. Though clinical examination is often normal, emotional facial paresis has been described in patients with TLE. Utilizing a well-characterized group of mesial TLE (MTLE) patients, who have achieved excellent seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL), we investigated the prevalence, predictive value and associations of emotional facial paresis. When compared to 8 out of 50 control subjects (16%), 36 out of 50 MTLE patients (72%) exhibited unilateral emotional facial paresis; the difference was highly significant (P<0.0001). The presence of contralateral emotional facial paresis correctly predicted the side of ATL in 86.1% patients. The occurrence of emotional facial paresis was significantly associated with longer duration of epilepsy prior to ATL and left ATL. Our observations confirm that emotional facial parersis contralateral to the side of mesial temporal sclerosis (MTS) is a valuable localizing sign in correctly predicting the epileptogenic temporal lobe. We hypothesize that the presence of an intact right hemisphere and pathological changes more extensive than MTS may be required for emotional facial paresis to readily manifest.  (+info)

Unexpected amnesia: are there lessons to be learned from cases of amnesia following unilateral temporal lobe surgery? (3/100)

Cases of amnesia following unilateral temporal lobe surgery are rare, but they may provide important insights into human brain functioning. Such cases are reconsidered here in the light of recent developments in clinical and cognitive neuroscience. Descriptions of preoperative seizure activity in these cases indicate the potentially valuable role of ictal semiology in localizing the source of epileptiform discharges. Cases of amnesia after unilateral temporal lobectomy illustrate the complexity of intra- and inter-hemispheric propagation of epileptiform discharges and highlight possible neurophysiological mechanisms underlying false localization of abnormal EEG activity. This review points to the value of preoperative neuropsychological assessment in providing information on the likely primary locus of pathology and in predicting outcome after surgery. The analysis of cases upholds the benefits of the Wada procedure, but it highlights the variability in Wada test procedures and the fact that Wada test scores themselves may be open to varying interpretation. These cases of postoperative amnesia are further considered in the context of the cognitive neuroscience of human memory and, in particular, mechanisms underlying the human amnesic syndrome. They confirm the critical role of bilateral medial temporal lobe structures in anterograde memory, but they also highlight the complexity in teasing apart neural mechanisms underlying remote memory loss.  (+info)

A specific role for the human amygdala in olfactory memory. (4/100)

The medial temporal lobe is known to play a role in the processing of olfaction and memory. The specific contribution of the human amygdala to memory for odors has not been addressed, however. The role of this region in memory for odors was assessed in patients with unilateral amygdala damage due to temporal lobectomy (n = 20; 11 left, 9 right), one patient with selective bilateral amygdala damage, and in 20 age-matched normal controls. Fifteen odors were presented, followed 1 h later by an odor-name matching test and an odor-odor recognition test. Signal detection analyses showed that both unilateral groups were impaired in their memory for matching odors with names, these patients were not significantly impaired on odor-odor recognition. Bilateral amygdala damage resulted in severe impairment in both odor-name matching as well as in odor-odor recognition memory. Importantly, none of the patients were impaired on an auditory verbal learning task, suggesting that these findings reflect a specific impairment in olfactory memory, and not merely a more general memory deficit. Taken together, the data provide neuropsychological evidence that the human amygdala is essential for olfactory memory.  (+info)

Emotional memory and perception in temporal lobectomy patients with amygdala damage. (5/100)

BACKGROUND: The human amygdala is implicated in the formation of emotional memories and the perception of emotional stimuli--particularly fear--across various modalities. OBJECTIVES: To discern the extent to which these functions are related. METHODS: 28 patients who had anterior temporal lobectomy (13 left and 15 right) for intractable epilepsy were recruited. Structural magnetic resonance imaging showed that three of them had atrophy of their remaining amygdala. All participants were given tests of affect perception from facial and vocal expressions and of emotional memory, using a standard narrative test and a novel test of word recognition. The results were standardised against matched healthy controls. RESULTS: Performance on all emotion tasks in patients with unilateral lobectomy ranged from unimpaired to moderately impaired. Perception of emotions in faces and voices was (with exceptions) significantly positively correlated, indicating multimodal emotional processing. However, there was no correlation between the subjects' performance on tests of emotional memory and perception. Several subjects showed strong emotional memory enhancement but poor fear perception. Patients with bilateral amygdala damage had greater impairment, particularly on the narrative test of emotional memory, one showing superior fear recognition but absent memory enhancement. CONCLUSIONS: Bilateral amygdala damage is particularly disruptive of emotional memory processes in comparison with unilateral temporal lobectomy. On a cognitive level, the pattern of results implies that perception of emotional expressions and emotional memory are supported by separate processing systems or streams.  (+info)

Schizophrenia-like psychosis arising de novo following a temporal lobectomy: timing and risk factors. (6/100)

OBJECTIVES: To clarify risk factors for the development of schizophrenia-like psychotic disorders following temporal lobectomy, and to explore the possibility that the early postoperative period is a time of high risk for the onset of such chronic psychotic disorders. METHODS: Patients who developed schizophrenia-like psychosis were identified from a series of 320 patients who had a temporal lobectomy for medically intractable epilepsy. The relationship of their disorders to both the operation and subsequent seizure activity was examined. Using a retrospective case-control design, risk factors for the development of schizophrenia-like psychosis were established. RESULTS: Eleven patients who developed schizophrenia-like psychosis postoperatively were identified and compared with 33 control subjects who remained free of psychosis postoperatively. The onset of de novo psychotic symptoms was typically in the first year following the operation. No clear relationship between postoperative seizure activity and fluctuations in psychotic symptoms emerged. Compared with the controls, patients who become psychotic had more preoperative bilateral electroencephalogram (EEG) abnormalities, pathologies other than mesial temporal sclerosis in the excised lobe and a smaller amygdala on the unoperated side. CONCLUSIONS: Temporal lobectomy for medically intractable epilepsy may precipitate a schizophrenia-like psychosis. Patients with bilateral functional and structural abnormalities, particularly of the amygdala, may be at particular risk for the development of such psychoses.  (+info)

Temporal lobectomy: long-term seizure outcome, late recurrence and risks for seizure recurrence. (7/100)

There is little information available relevant to long-term seizure outcome after anterior temporal lobectomy, particularly at extended postoperative periods. The aim of this study was an in-depth examination of patterns of longitudinal outcome and potential risk factors for seizure recurrence after lobectomy, utilizing a large patient sample with long follow-up. Included were 325 patients who underwent anterior temporal lobectomy between 1978 and 1998 (mean follow-up 9.6 +/- 4.2 years). Retrospective data were analysed using survival analysis and multivariate regression with Cox proportional hazard models. The probability of complete seizure freedom at 2 years post-surgery was 55.3% [95% confidence interval (CI) 50-61]; at 5 years, 47.7% (95% CI 42-53); and at 10 postoperative years it was 41% (95% CI 36-48). Patients with discrete abnormalities preoperatively (i.e. lesions and hippocampal sclerosis) had a significantly higher probability of seizure freedom than patients without obvious abnormality. The latter group had a pattern of recurrence similar to that in patients with lesions outside the area of excision. After adjustment for preoperative pathology, only the presence of preoperative secondarily generalized seizures had a significant association with recurrence [occasional preoperative generalized seizures, hazard ratio (HR) 1.6, 95% CI 1.1-2.3; frequent seizures, HR 2.0, 95% CI 1.4-2.9 compared with absence of preoperative generalized seizures]. Duration of preoperative epilepsy, age of seizure onset and age at surgery did not have an effect on outcome. Patients with two seizure-free postoperative years had a 74% (95% CI 66-81) probability of seizure freedom by 10 postoperative years. This late seizure recurrence was not associated with any identified risk factors. Specifically, patients with hippocampal sclerosis were not at higher risk. Surprisingly, complete discontinuation of anti-epileptic drugs (AEDs) after two postoperative years was not associated with an increased risk of recurrence (HR 1.03, 95% CI 0.5-2.1). This may be because selection of patients for AED discontinuation is biased towards those individuals perceived as 'low risk'. The results of this study indicate that the lack of an obvious abnormality or the presence of diffuse pathology, and preoperative secondarily generalized seizures are risk factors for recurrence after surgery. Late recurrence after initial seizure freedom is not a rare event; risk factors specific to this phenomenon are as yet unidentified.  (+info)

Cerebellar hemorrhage as a complication of temporal lobectomy for refractory medial temporal epilepsy: report of three cases. (8/100)

Cerebellar hemorrhage is listed among the potential complications following neurosurgical procedures. In this scenario it is usually reported as a rare condition. However, it seems that epilepsy surgery patients are somewhat more prone to this kind of complication, compared to other surgical groups. Head positioning, excessive cerebral spinal fluid draining and the excision of non-expanding encephalic tissue (or combinations among the three) are likely to be cause underlying remote cerebellar hemorrhage. Out of the 118 ATL/AH performed at our institution, between 1996 and 2002, we identified 3 (2.5%) patients presenting with cerebellar hemorrhage. We report on such cases and review the literature on the topic.  (+info)

(2010) Liang et al. Seizure. Aims: To investigate the surgical outcomes of anterior corpus callosotomy (aCCT) combined with anterior temporal lobectomy (ATL) in patients with intractable temporal lobe epilepsy (TLE) and mental retardation (MR). Methods: Sixty patients with TLE and MR were careful...
White matter connexions can be delineated and quantified in vivo using diffusion MRI and tractography.1 ,2 Asymmetry of white matter tracks is well-described, with larger left than right corticospinal tracts in group analyses.3. The literature on arcuate fasciculus asymmetry is mixed. In individual subjects, some studies have shown a correlation between the volume of the arcuate fasciculus tract and language lateralisation, determined by the WADA test4 and by functional MRI (fMRI)I,5 while others have not found a consistent association.6 Recent work suggests the fasciculus may in fact be composed of two parallel tracts, with independent associations to language dominance.3 ,7. Meyers loop is the anterior bundle of the optic radiation, a white matter tract that makes up part of the visual pathway. Meyers loop runs from the lateral geniculate nucleus of the thalamus, passes anteroinferiorly over the temporal horn of the lateral ventricle and then sharply turns posteriorly to join the central and ...
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and is responsible for 15%-20% of epilepsy cases in children. Class I evidence strongly supports the use of temporal lobectomy for intractable TLE in adults, but fewer studies have examined seizure outcomes and predictors of seizure freedom after temporal lobectomy in pediatric patients. The authors performed a systematic review and meta-analysis of studies including 10 or more pediatric patients (age ≤ 19 years) published over the last 20 years examining seizure outcomes after temporal lobectomy for TLE. Thirty-six studies met their inclusion criteria. These 36 studies included 1318 pediatric patients with a mean age (± SEM) of 10.7 ± 0.3 years. Overall, seizure freedom (Engel Class I outcome) was achieved in 1002 cases (76%); 316 patients (24%) continued to have seizures (Engel Class II-IV outcome). All patients had at least 1 year of follow-up. Statistically significant predictors of seizure freedom after surgery ...
Data were collected for all children undergoing temporal resections at four epilepsy centers over approximately 10 years. Children with a histopathological diagnosis of neoplasm were excluded.. Forty-nine patients (28 boys and 21 girls) were included in the study. Their mean age at surgery was 9.1 years (range 1.25-13.9 years). The mean age at seizure onset was 3.2 years (range birth-10 years). Histopathological examination demonstrated MTS in 26 cases, gliosis in nine, dysplasia in five, gliosis with dysplasia in four, and nonspecific or normal findings in five. Forty-one anterior temporal lobectomies (nine tailored) and eight selective amygdalohippocampectomies were performed (28 left side, 21 right side). Twenty-nine children (59.2%) underwent invasive monitoring. Operative complications included extraaxial hematomas (two cases), cerebrospinal fluid leaks (two cases), and hydrocephalus (one case), each in children undergoing invasive monitoring. The mean duration of follow up was 26.4 months ...
We describe an epileptic syndrome of bilaterally coordinated limb movements, axial movements, vocalization, and nonmasticatory oral activity. EEG and physiologic evidence indicates the syndrome is caused by ictal discharge in the mesial frontal lobes. Two of 12 patients were not helped by anterior temporal lobectomy, and 3 others improved after section of the anterior two-thirds of the corpus callosum.. ...
Part of the optic radiation which sweeps back on itself into the temporal lobe, just lateral to the temporal horn of the lateral ventricle. It can be injured in temporal lobectomy, resulting in a superolateral field cut, the so called pie-in-the-sky field cut. (radiopaedia.org). ...
refractoriness to treatments psychiatric comorbidity dual pathology and severe biopsychosocial damage tenders Tender Notices RFP Rfq compiled daily from all published Newspapers online web portals other sources of tender issuing authorities world wide
The purpose of this study is to determine whether one dose of denosumab can lead to changes in the tumor, which may decrease the ability of tumor to spread.
In previous communications1 we pointed out that the chief symptoms following bilateral temporal lobectomy in the rhesus monkey consist in
Mrs. Meyers Clean Day Glass Hand Soap Bottle is a refillable bottle with nickel-brushed pump, ready to be filled with your favorite liquid hand soap.
This trial studies how well the use of a pre-surgical toolkit (OPTI-Surg) works in improving surgical care and outcomes in older participants with cancer. In many elderly patients, surgery can greatly affect physical condition and the ability to return to pre-surgery levels of physical functioning. Providing pre-surgical recommendations may help improve participants recovery
path-breaking...Meyer demonstrates brilliantly the shifts in articulation of cultural and political identities as well as change of the specific vocabulary in the written texts of the Turkic intellectuals.--Jahrbücher für Geschichte Osteuropas. Meyers book is a page-turner, admittedly not a common trait in scholarly history works. It frequently turns into a sort of amusement park for historians, where the author parades so many newly unearthed, rich in detail, and immensely informative archival documents...finely tackles somewhat delicate yet thorny matters such as Turkism, Pan-Turkism, Ottomanism, and Islamism, as well as addresses the lives of humans who were doomed and perished or sometimes enriched and saved by those very same matters. --American Historical Review ...
Ive talked a bit in the past about good concept inventory questions - questions that address difficult conceptual questions but have black and white answers and dont require any special vocabulary to answer. Dan Meyers Linear Modeling exercise [PDF] is a good example. The first question has a specific answer, and answering it requires the right…
George Atallah of the NFLPA drops by to explain why the union is investigating Urban Meyers comments on vaccination status affecting the Jaguars ros
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While my chapter in Signature of Controversy responding to Stephen Mathesons review of Signature in the Cell deals with a variety of issues, I
Our hardworking dish soap sends grease packing in a jiff. And with plant-derived and other thoughtfully chosen ingredients, its biodegradable, too.
ENGEL GIERGIEL MECHANIKA PDF - Engel Z, Giergiel J. Dynamika . In: Mechanika techniczna . Kraków: Wydawnictwa AGH. , Dynamika lotu, Część I Aerodynamika,. Część II Mechanika lotu.
Engel & Völkers Platja dAro in Platja d´aro. The real estate agency Engel & Völkers Platja dAro at Avenida de S´Agaró, 90 en now has 49 properties in this area.
TY - JOUR. T1 - Visual field defects after selective amygdalohippocampectomy and standard temporal lobectomy. AU - Mengesha, T.. AU - Abu-Ata, M.. AU - Haas, K. F.. AU - Lavin, P. J.. AU - Sun, D. A.. AU - Konrad, P. E.. AU - Pearson, M.. AU - Wang, L.. AU - Song, Y.. AU - Abou-Khalil, B. W.. PY - 2009/9/1. Y1 - 2009/9/1. N2 - Background:: Selective amygdalohippocampectomy (SelAH) is increasingly performed in patients with mesial temporal lobe epilepsy and hippocampal sclerosis. To determine whether visual field defects are less pronounced after SelAH than after standard temporal lobectomy (StTL), we retrospectively analyzed postoperative quantitative visual fields after the 2 procedures. METHODS:: Humphrey visual field analysis was obtained postoperatively in 18 patients who had undergone SelAH and in 33 patients who had undergone StTL. The SelAH was performed via a transcortical approach through the middle temporal gyrus and included the amygdala, 3 cm of the hippocampus, and the ...
Methods: We studied 23 medically refractory TLE patients who underwent anterior temporal lobectomy and who had preoperative FDG-PET scanning. All patients had pre- and postoperative psychiatric assessment. By using statistical parametric mapping (SPM-99), patterns of hypometabolism were compared between patients who had a preoperative history of depression (n = 9) versus those who did not (n = 14) and between those in whom postoperative depression developed (n = 13) versus those in whom it did not (n = 10). A significant region of hypometabolism was set at p , 0.001 for a cluster of ≥20 contiguous voxels ...
Unilateral hippocampal atrophy with or without temporal cortical atrophy on qualitative MR imaging, other unitemporal structural lesions on qualitative MR imaging, and a hippocampal volume reduction of at least 1 SD from the mean of controls on the side of seizure onset predicted Engel I-II outcome in a logistic regression analyses. Qualitative MR imaging reveals lateralising abnormalities in 74%, and hippocampal atrophy in 52-63% of patients undergoing epilepsy surgery for temporal lobe epilepsy.13,39,44 Volumetric MR imaging studies have shown that up to 88% of patients with drug resistant temporal lobe epilepsy have hippocampal damage on quantitative MR imaging.45 Both ipsilateral hippocampal damage and ipsilateral foreign tissue lesions on MR imaging are important predictors of successful postoperative outcome in patients undergoing surgery for drug refractory temporal lobe epilepsy.13,14,15 In various different studies, 62-96% of patients with hippocampal damage on MR imaging became ...
This study illustrates the outcome and cost-effectiveness of anterior temporal lobectomy (ATL) among patients with medically refractory temporal lobe epilepsy (TLE) treated in an epilepsy center in Kerala, South India. Patients for ATL were selected on the basis of a noninvasive protocol comprising clinical, interictal scalp electroencephalogram (EEG), magnetic resonance imaging, and ictal video-EEG data. The authors compared the outcome and direct cost of 119 patients (mean age, 25.6 years; mean duration of epilepsy before ATL, 16.1 years) who have completed at least 1 year follow-up after ATL with 71 refractory TLE patients (mean age, 27.1 years; mean duration of epilepsy, 15.4 years) who did not undergo ATL. Patients in the study who underwent ATL had a 70% likelihood of becoming seizure-free after ATL and a 30% chance of being completely off of antiepileptic drug treatment within 3 years after ATL. The out-of-pocket one-time payment for ATL (including presurgical evaluation) in this setup is ...
Minoo Shams-Moorkani, MD, is an epileptologist who provides care in the Neurology Clinic at M Health Fairview Clinics and Surgery Center - Maple Grove and M Health Fairview Park Place East MINCEP Epilepsy Care. Dr. Shams-Moorkani is capable of a variety of treatments, including anterior temporal lobectomy, continuous video electroencephalogram, lesionectomy and vagus nerve stimulation. She is also an Assistant Professor with the Department of Neurology for the University of Minnesota. ...
see also amygdalohippocampectomy. A certain number of patients suffer significant decline in verbal memory after hippocampectomy. To prevent this disabling complication, a reliable test for predicting postoperative memory decline is greatly desired. Therefore, Tani et al., assessed the value of electrical stimulation of the parahippocampal gyrus (PHG) as a provocation test of verbal memory decline after hippocampectomy on the dominant side. Eleven right-handed, Japanese-speaking patients with medically intractable left temporal lobe epilepsy (TLE) participated in the study. Before surgery, they underwent provocative testing via electrical stimulation of the left PHG during a verbal encoding task. Their pre- and posthippocampectomy memory function was evaluated according to the Wechsler Memory Scale-Revised (WMS-R) and/or Mini mental state examination (MMSE) before and 6 months after surgery. The relationship between postsurgical memory decline and results of the provocative test was evaluated. ...
As a prognostic tool, fMRI may also be considered for predicting language deficits or nonverbal memory outcomes that may occur after a patient undergoes temporal lobe resection (both recommendations based on Level C evidence).. However, the test should be considered for predicting verbal memory outcomes in patients undergoing left medial lobe surgery (Level B).. We now know there is evidence that supports the use of fMRI for presurgical evaluation, lead author Jerzy P. Szaflarski, MD, PhD, professor of neurology at the University of Alabama at Birmingham (UAB) and director of the UAB Epilepsy Center, told Medscape Medical News.. People were already using it for this purpose. So we wanted to put this information in a form that allows clinicians to look at the evidence and decide what is best for the individual patient, added Dr Szaflarski.. Keep Reading at Medscape. ...
The application of non-invasive imaging methodologies in the study of epilepsy is quite used, but often these techniques are separately considered. Indeed, because of the different nature of the investigation methods, their combination is difficult although would allow to obtain a more specific diagnosis of the epileptic patient. The chance to investigate the pathophysiology of different mechanisms involved in epilepsy and to find different therapeutic approaches is allowed by the used of new multimodal examinations. Different techniques such as electroencephalography-functional magnetic resonance imaging (EEG-fMRI) coregistration, high density EEG (hdEEG), Arterial Spin Labeling (ASL), Positron Emission Tomography (PET) can be combined to non-invasively map abnormal brain activation elicited by epileptic processes. EEG-fMRI can provide information on the pathophysiological processes underlying interictal activity, since the hemodynamic changes are a consequence of the abnormal
Although psychologists and neurologists have been familiar with the case of H.M. for years, this small volume makes his story-and what it can teach us about the functioning of memory-accessible to a much wider audience. Hilts has done a good job of piecing together H.M.s early life, in the absence of any living relatives and all but a few written records. He recreates the life of a very normal youth in the 1930s and 1940s; normal, that is, until H.M.s first epileptic seizure. In 1954, after several other treatments for the epilepsy had failed, H.M. (at age 27) had a bilateral medial temporal lobectomy, in the hope that it would alleviate his seizures. A neurosurgeon removed large sections of both temporal lobes, as well as much of the limbic system, including the amygdala and hippocampus. Since the surgery, H.M.-who was still alive when the book was written-suffers from a pervasive anterograde amnesia. In particular, H.M. has contributed greatly to our understanding of the neuroanatomy of memory and
A temporal lobectomy led to profound memory impairment in a man who became the subject of neuroscientists for the rest of his life-and beyond.. 0 Comments. ...
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Coastal Neuropsychological Services was founded in Wilmington, NC in 1998 by Dr. Christy Jones. We provide clinical neuropsychology, psychological evaluations, forensic neuropsychology, and treatment, as well as pre-surgical evaluations and the diagnosis and treatment of many other psychological conditions. We offer the highest level of patient care in a warm, welcoming environment.
Our pre-surgical clinic (PSC) prepares you for your surgery. Once your surgery has been booked, you will receive a call to book your pre-surgical clinic appointment. Your appointment should be booked at least two to four weeks before your surgery.
Everything you need to know about pre-surgical psychology screenings (PPS), the post-surgical blues, & combating surgery anxiety.
September 29th, 2011 at 2:16 am. Hmm, Luskin wrote a big reply and then closed comments, which sadly I noticed only after composing a reply. Ill post it here.. Casey - very briefly as I am in London and will not spend too much time on this -. 1. One of the points of Meyers book was that his argument was different than Behes and Dembskis, and added something to them. He says this several times, that hes not just rehashing their arguments. But, when you are defending the book, you retreat to IC-like arguments. So what was the point of the book and all of the subsequent rhetoric? We might as well have just ignored Meyers book and should have just kept arguing about whether the IC argument works, since the information argument cant stand on its own without IC supporting it. As it stands, while playing defense youve walked Meyers argument all the way back to evolution cant produce new protein folds, which is dramatically less bold than claiming that evolution cant produce new genes and ...
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Going in for surgery Friday for lobectomy on right lung. Diagnosed with mass on right lung in addition to another primary cancer in my left lung (which will be dealt with after my surgery on the...
Care guide for Lung Lobectomy (Precare). Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
Meh. I know its natural. I know its supposed to be good but it doesnt beat dawn or Palmolive. Its expensive and you have to use quite a bit. Not going to re...
The liver is made up of six lobes. Often if a tumor has developed, the removal of the entire lobe where it is located is the safest course of action to prevent the spread of cancer. - Wag! (formerly Vetary)
TY - JOUR AU - Ristic, Aleksandar J. AU - Sokic, Dragoslav AU - Baščarević, Vladimir AU - Spasić, Snežana AU - Vojvodic, Nikola AU - Savić, Slobodan AU - Raičević, Savo AU - Kovacevic, Masa AU - Savic, Danijela AU - Spasojević, Ivan PY - 2014 UR - http://cer.ihtm.bg.ac.rs/handle/123456789/1583 AB - An altered metal and electrolyte profile has been implicated in the pathologic mechanisms of chronic epilepsy; however, no study has comprehensively measured hippocampal concentrations of these elements in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (mTLE-HS). We therefore analyzed hippocampi of 24 patients with drug-resistant mTLE-HS (mean age 35.69.4years) who underwent anterior temporal lobe resection and amygdalohippocampectomy and 17 hippocampi obtained by autopsy from 13 controls (mean age 40.5 +/- 12.9years), using inductively coupled plasma optical emission spectrometry (ICP-OES). Epileptic hippocampi showed significantly lower concentrations (g/g of tissue) ...
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541 ...
PURPOSE OF REVIEW: This review summarizes recent evidence on the seizure, safety, cognitive and psychosocial outcomes of epilepsy surgery and their predictors. RECENT FINDINGS: Risks of serious surgical complications have dramatically decreased over years to drop below 1% for temporal lobe resections. Although chances of postoperative seizure freedom largely vary between recent series, some data suggest that long-term seizure control might be achieved in over 80% of patients with mesial temporal lobe epilepsy or neocortical epilepsy associated with type 2 focal cortical dysplasia, and in up to two-thirds of patients with extratemporal lobe epilepsy. In the same conditions, some recent series challenge the classic view that a normal MRI is associated with worse outcome, an important finding given the greater proportion of MRI-negative patients now considered for epilepsy surgery. SUMMARY: These provocative findings appear to partly reflect the advances in the optimal use or postprocessi
TY - JOUR. T1 - Predictive role of dynamic contrast enhanced T1-weighted MR sequences in pre-surgical evaluation of macroadenomas consistency. AU - Romano, Andrea. AU - Coppola, Valeria. AU - Lombardi, Mariangela. AU - Lavorato, Luigi. AU - Di Stefano, D.. AU - Caroli, Emanuela. AU - Rossi Espagnet, Maria Camilla. AU - Tavanti, F.. AU - Minniti, Giuseppe. AU - Trillò, Giuseppe. AU - Bozzao, Alessandro. PY - 2016/10/11. Y1 - 2016/10/11. N2 - Purpose: Our hypothesis was that pituitary macroadenomas show different areas of consistency detectable by enhanced magnetic resonance imaging (MRI) with Dynamic study during gadolinium administration. Materials and methods: We analysed 21 patients with pituitary macroadenomas between June 2013 and June 2015. All patients underwent trans-sphenoidal surgery and neurosurgeon described macroadenomas consistency. Similarly, two neuroradiologists manually drew regions of interest (ROIs) inside the solid-appearing portions of macroadenoma and in the normal white ...
[Mesial temporal sclerosis (I): histological data, physiopathological hypothesis and etiological factors].: Probably these organic changes are both the cause an
This case concerns a patient with generalized neurosarcoidosis and pharmacoresistant focal epilepsy. Although immunosuppressive therapy resulted in remission of the neurosarcoidosis, seizures continued and were shown to originate from the right temporal lobe (TL). The patient underwent a right anterior temporal lobe resection (TLR) and obtained >90% reduction of seizure frequency. ...
Success rates for epilepsy surgery are well known. Until recently, success following surgery was defined primarily in terms of seizure reduction. However, more attention is now placed on the inclusion of cognitive and behavioral functioning as primary defining features of epilepsy and as important factors considered within the definition of surgical outcome. With that in mind, it has been determined that a cognitive price is paid by up to 40% of patients undergoing surgery, regardless of the resulting level of seizure control. It is thus important for surgical treatment teams to have effective methods of determining which surgical candidates are at risk for paying this important price, so that effective preventative strategies can be developed and implemented.. What we know thus far is that the rate of memory decline is highest in patients undergoing left (dominant) temporal lobe resections. The primary approach to identifying risk for memory decline has been to evaluate the presurgical ...
Responsive nerve stimulation (RNS) represents a safe and effective treatment option for patients with medically refractory temporal lobe epilepsy. In cases of long intraparenchymal course and posterior-anterior electrode direction through occipital burr holes, disciplined stereotaxy is essential for stimulation of the appropriate target. A 13-year-old female with a history of multifocal, independent, bitemporal-onset seizures since 12 months of age showing evidence of left-sided mesial temporal sclerosis on MRI, underwent placement of bilateral mesial temporal RNS leads. An O-arm spin was performed after the placement and the images obtained were fused to the preoperative CT images. It demonstrated curvature of the leads, with some deviation from the planned trajectory, but no deviation from the target, that was worse on the left side, compared to the right; the left lead was placed first, followed by the right lead. Following discussion with our epilepsy neurology colleagues in the operating ...
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My epilepsy story contains two very different neurological events. I was born in 1975 with a defect in my left temporal lobe that caused seizures unresponsive to treatment until I had a left temporal lobectomy in 1996. That successful surgery let me live seizure free for nine years, graduate from college with an engineering degree, have a great job, and lead a normal life.. The second event was in 2005 when I had encephalitis which caused seizures arising from the right temporal lobe and loss of short-term memory. Treatment with medications did nothing, and another surgical resection was not possible.. My epileptologist in San Francisco recommended NeuroPace. It can be a life-changing decision, and I decided to undergo implant surgery as soon as possible after the FDA approved its use. I received the implant on June 20, 2014. It gives my doctors 24-7 EEG information about my brains electrical activity, which allows changes in treatment personalized for me. This opens the door for continued ...
According to a study published in the Annals of Neurology, early seizures after temporal lobectomy, the most common form of epilepsy surgery, signal that the patient will continue to have seizures.
This exhibit features an axial MRI rendition of the head demonstrating current conditions. Porencephaly is seen in the right temporal lobe, secondary to partial temporal lobectomy. Encephalomalacia and gliosis are depicted surrounding the areas of prior injury.
Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy in adults and commonly requires surgical treatment. While an overwhelming preponderance of literature supports the notion that a large percentage of patients with TLE benefit from surgery, there is a paucity of outcome data on patients who demonstrate a sustained response to pharmacological treatment. In this study, we present an adult cohort of patients with TLE, with the purpose of identifying the proportion of patients with a mild course of the disease, as well as potential risk factors.. ...
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Hello all:)this is my first post since under going lower left lobectomy for carcinoid lung tumour. I wanted to share as prior to surgery many post I read were both informative and actually encouarging too. My surgery was performed 18th June 2012, just like everybody who gets informed they have tumour I was petrified and my mind went into overdrive like I never knew it could. On being advised best treatment option for me, was lobectomy I want to run as far away as possible and just not deal with this health issue at all. thankfully the little bit of sense I keep in reserve, always, finally kicked in and having researched and read helpful posts from others who had been through same procedure I went for it too. Without doubt day 2 after surgery was like..... OMG how will I ever be the same again. Pain was fairly controlled by medication but I did feel awful, however each and every day there after things just got better & better. For me I would say first 4/6 weeks not feeling great and truly ...
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With nearly two decades of experience in politics and 15 years in health care and marketing, Engel Burns has become a highly successful Washington lobbyist. Currently serving as the Federal Account Director of Government Affairs for Sunovion Pharmaceuticals, Inc., Engel Burns recently discussed his road to success with Ebony magazine. In the article in Ebony,…
Schwertberg, Austria - Rubber and plastics machinery maker Engel Holding GmbH generated sales of €1.36bn in the fiscal year ended 31 March - an increase of 8.6% from the year before.. Engel officials said that marked the third straight year of increasing sales.. Engel, based in Schwertberg, Austria, began the new fiscal year with a workforce of 5,900, a new record - and employment will pass the 6,000 level in its first quarter, officials said.. ...
Engel This song is by Helium Vola and appears on the album Liod (2004). Nisal nieman Then diubal uorhtan Uuanda her nemach manne scada sin. Iz nihengi imo use druhttin. External links Nominate as Song of the Day iTunes: buy Engel Amazon: search for… Helium Vola • Liod • Engel Hype Machine...
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Severely malnourished due to her cleft palate, 1-month-old Janat was on the verge of starvation before a team of volunteer dentists intervened.
Neuroscientists report the results of three years of brain imaging and behavioral tests on the boy, known in scientific literature as UD.
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