Antennapedia Homeodomain Protein: Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA.Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).Genes, Homeobox: Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Insect evolution: Redesigning the fruitfly. (1/172)

Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations.  (+info)

Potential variance affecting homeotic Ultrabithorax and Antennapedia phenotypes in Drosophila melanogaster. (2/172)

Introgression of homeotic mutations into wild-type genetic backgrounds results in a wide variety of phenotypes and implies that major effect modifiers of extreme phenotypes are not uncommon in natural populations of Drosophila. A composite interval mapping procedure was used to demonstrate that one major effect locus accounts for three-quarters of the variance for haltere to wing margin transformation in Ultrabithorax flies, yet has no obvious effect on wild-type development. Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. Introgression of Antennapedia produces lines with heritable phenotypes ranging from almost complete suppression to perfect antennal leg formation, as well as transformations that are restricted to either the distal or proximal portion of the appendage. It is argued that the existence of "potential" variance, which is genetic variation whose effects are not observable in wild-type individuals, is a prerequisite for the uncoupling of genetic from phenotypic divergence.  (+info)

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. (3/172)

The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. Here we report that synthetic peptides corresponding to the BH3 domain of Bak bind to Bcl-xL, antagonize its anti-apoptotic function, and rapidly induce apoptosis when delivered into intact cells via fusion to the Antennapedia homeoprotein internalization domain. Treatment of HeLa cells with the Antennapedia-BH3 fusion peptide resulted in peptide internalization and induction of apoptosis within 2-3 h, as indicated by caspase activation and subsequent poly(ADP-ribose) polymerase cleavage, as well as morphological characteristics of apoptosis. A point mutation within the BH3 peptide that blocks its ability to bind to Bcl-xL abolished its apoptotic activity, suggesting that interaction of the BH3 peptide with Bcl-2-related death suppressors, such as Bcl-xL, may be critical for its activity in cells. While overexpression of Bcl-xL can block BH3-induced apoptosis, treatment with BH3 peptides resensitized Bcl-xL-expressing cells to Fas-mediated apoptosis. BH3-induced apoptosis was blocked by caspase inhibitors, demonstrating a dependence on caspase activation, but was not accompanied by a dramatic early loss of mitochondrial membrane potential or detectable translocation of cytochrome c from mitochondria to cytosol. These findings demonstrate that the BH3 domain itself is capable of inducing apoptosis in whole cells, possibly by antagonizing the function of Bcl-2-related death suppressors.  (+info)

Activity regulation of Hox proteins, a mechanism for altering functional specificity in development and evolution. (4/172)

The closely related Hox transcription factors Ultrabithorax (Ubx) and Antennapedia (Antp) respectively direct first abdominal (A1) and second thoracic (T2) segment identities in Drosophila. It has been proposed that their functional differences derive from their differential occupancy of DNA target sites. Here we show that a hybrid version of Ubx (Ubx-VP16), which possesses an enhanced transcriptional activation function, no longer directs A1 denticle pattern in embryonic epidermal cells. Instead, it mimics Antp in directing T2 denticle pattern, and it can rescue the cuticular loss-of-function phenotype of Antp mutants. In cells that do not produce denticles, Ubx-VP16 appears to have largely retained its normal repressive regulatory functions. These results suggest that the modulation of Hox activation and repression functions can account for segment-specific morphological differences that are controlled by different members of the Hox family. Our results also are consistent with the idea that activity regulation underlies the phenotypic suppression phenomenon in which a more posterior Hox protein suppresses the function of a more anterior member of the Hox cluster. The acquisition of novel activation and repression potentials in Hox proteins may be an important mechanism underlying the generation of subtle morphological differences during evolution.  (+info)

The control of trunk Hox specificity and activity by Extradenticle. (5/172)

We characterize a 37-bp element (fkh[250]) derived from the fork head (fkh) gene, a natural target of the Hox gene Sex combs reduced (Scr). In vitro, Scr cooperatively binds to this DNA with the Hox cofactor Extradenticle (Exd), and the activation of this enhancer in vivo requires Scr and exd. Other Hox/Exd heterodimers do not activate this element in vivo and do not bind this element with high affinity in vitro. The amino-terminal arm of the Scr homeodomain is crucial for the specific activation of this element in vivo. By mutating two base pairs within this element, we can convert the Scr/Exd-binding site to a Hox/Exd consensus site that binds several different Hox/Exd heterodimers. This element, fkh[250(con)], is activated by Scr, Antennapedia (Antp), and Ultrabithorax (Ubx) but repressed by abdominal-A (abd-A). We also show that Scr and Exd are only able to activate the fkh[250] element during the early stages of embryogenesis because, by stage 11, Scr negatively regulates the gene homothorax (hth), which is required for the nuclear localization of Exd. These results suggest that Exd is a specificity cofactor for the trunk Hox genes, and that the control of Exd subcellular localization is a mechanism to regulate Hox activity during development.  (+info)

Structural organization and sequence of the homeotic gene Antennapedia of Drosophila melanogaster. (6/172)

The structure of the Drosophila melanogaster Antennapedia (Antp) gene has been investigated by the isolation and sequencing of different cDNAs and genomic clones. Northern analysis, S1 mapping and primer extension experiments reveal a complex and unusual gene structure. The gene is composed of two promoters, eight exons spanning >100 kb, and two termination processing regions. Four major polyadenylated transcripts were found, two of them starting at a second internal promoter in front of exon 3. All four transcripts have extremely long untranslated leader and trailer sequences in the range of 1-2 kb. Despite the complex transcriptional organization, the open reading frame is the same in all transcripts, and starts in exon 5 giving rise to a protein of mol. wt. 42 800. The putative protein is rich in glutamine (18%) and proline (10%). The homeobox, a region which previously has been shown to be highly conserved among homeotic genes, is contained in the open reading frame and located in the last exon. Functional implications of the complex structure with respect to development and its relation to the mutant phenotypes are discussed.  (+info)

A p21(Waf1/Cip1)carboxyl-terminal peptide exhibited cyclin-dependent kinase-inhibitory activity and cytotoxicity when introduced into human cells. (7/172)

In the present study, we report the cyclin-dependent kinase (Cdk)-inhibitory activity of a series of p21waf1/cip1 (p21) peptide fragments spanning the whole protein against the cyclin D1/Cdk4 and cyclin E/Cdk2 enzymes. The most potent p21 peptide tested in our initial peptide series, designated W10, spanned amino acids 139 to 164, a region of p21 that has been found independently to bind to proliferating cell nuclear antigen and also to inhibit Cdk activity. We go on to report the importance of putative beta-strand and 3(10)-helix motifs in the W10 peptide for cyclin-dependent kinase-inhibitory activity. We also describe the cellular activity of W10 and derivatives that were chemically linked to an antennapedia peptide, the latter segment acting as a cell membrane carrier. We found that the W10AP peptide exhibited growth inhibition that resulted from necrosis in human lymphoma CA46 cells. Furthermore, regions in the W10 peptide responsible for Cdk-inhibition were also important for the degree of this cellular activity. These studies provide insights that may eventually, through further design, yield agents for the therapy of cancer.  (+info)

Regulation of epidermal bullous pemphigoid antigen 1 (BPAG1) synthesis by homeoprotein transcription factors. (8/172)

In a recent gene-trap screen, we identified the gene coding for Epidermal Bullous Pemphigoid Antigen 1 (BPAG1) as a putative transcriptional target of Engrailed and of other homeoproteins with a glutamine in position 50 of their homeodomain. We now show that the nuclear addressing of the homeodomains of Engrailed (EnHD) and Antennapedia (AntpHD) upregulates BPAG1e transcription in immortalized human keratinocytes (GMA24FIA) expressing En1. This upregulation is not observed with AntpHD-Q50A, a variant of AntpHD in which a single mutation abolishes its high-affinity binding to target DNA, thus strongly suggesting that BPAG1e upregulation homeodomains reflects their specific recognition of homeoprotein-binding sites in the BPAG1e locus. This is further confirmed by DNase I footprinting and electrophoretic mobility shift assays that reveal, within the cloned BPAG1e promoter, several sites of direct interaction with EnHD and Engrailed. Co-transfection experiments in GMA24FIA human keratinocytes, COS-7 simian fibroblasts, and CHP-100 human neuroepithelial cells show that Engrailed, Hoxa-5, and Hoxc-8 regulate BPAG1e promoter activity and that this regulation is context-dependent. Finally, using a mouse line with LacZ inserted within the En1 locus, we identify the keratinocytes of the ventral paws, including the epithelial cells of the eccrine tubules, as a strong site of En1 expression throughout adulthood. We therefore propose that BPAG1e, a 230 kDa keratin-binding protein expressed in keratinocytes and participating in the maintenance of hemidesmosomes at the dermis-epidermis border, is directly regulated by homeoprotein transcription factors.  (+info)

*Antennapedia

... Homeodomain Protein at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Antennapedia ... Antennapedia is a HOM-C gene first discovered in Drosophila which controls the formation of legs during development. Loss-of- ... Antennapedia also refers to a gene complex in Drosophila which is responsible for formation and differentiation of the thoracic ... It is suggested that Antennapedia arose from Evx, a non-Hox family of genes. This duplication event of Evx into the Antp-class ...

*HOXB7

"Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood. 78 (4): 1047-55. PMID ... Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene. This gene is a member of the Antp homeobox ... "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". ... "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663-74. ...

*Hox gene

... the resulting protein will recognize Antennapedia-binding enhancer sites. However, all homeodomain-containing transcription ... The ability of Hox proteins to bind DNA is conferred by a part of the protein referred to as the homeodomain. The homeodomain ... homeodomains of individual Hox proteins usually exhibit greater similarity to homeodomains in other species than to proteins ... Hox proteins are a subset of the homeodomain-containing transcription factors, which are proteins that are capable of binding ...

*Homeobox

The homeodomain binds DNA in a sequence-specific manner. However, the specificity of a single homeodomain protein is usually ... "Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex". Journal of ... These genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure ... Such complexes have a much higher target specificity than a single homeodomain protein. Homeodomains are encoded both by genes ...

*Proboscipedia (pb gene)

A homeobox gene is a transcription factor in which a region known as a homeodomain binds to a target gene promoter and controls ... Proboscipedia, also known as the pb gene, is a protein coding gene in Drosophila melanogaster, or fruit fly. This hox gene ... Proboscipedia belongs to the Antennapedia (Antp) homeobox family and the Proboscipedia subfamily. ...

*MEOX2

Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 ... This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded ... Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene. ... "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274-8. doi:10.1016/ ...

*Regional differentiation

All homeotic genes share a segment of protein with a similar sequence and structure called the homeodomain (the DNA sequence is ... The Antennapedia complex and the bithorax complex on the third chromosome contain the major homeotic genes required for ... These proteins are known to be ligands for the Notch protein. GLP-1, a Notch protein, is also required for specification of the ... mom-2 is a member of the Wnt family of proteins (i.e. the signal) and mom-5 is a member of the frizzled family of proteins (i.e ...

*Homeosis

Thus, the 60 amino acid DNA binding protein domain was named the homeodomain, while the 180 bp nucleotide sequence encoding it ... Another well-known example is Antennapedia: a gain-of-function allele causes legs to develop in the place of antennae. In ... The homeotic-function of certain proteins was first postulated to be that of a "selector" as proposed by Antonio Garcia-Bellido ... By definition selectors were imagined to be (transcription factor) proteins that stably determined one of two possible cell ...

*Homeotic selector gene

Homeodomain proteins are transcription factors that share a DNA-binding domain called the homeodomain. Changes in the ... For example, the lab gene is found in the 3' position in the Antennapedia complex, and is expressed in the most anterior head ... They encode homeodomain proteins which interact with Hox and other homeotic genes to initiate segment-specific gene regulation ... The proteins do not bind directly to the DNA, rather, they interact with other regulatory proteins which are already bound to ...

*Cell-penetrating peptide

Cell internalization of the third helix of the Antennapedia homeodomain is receptor independent. J. Biol. Chem. 271: 18188- ... The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly ... Several groups have successfully delivered CPP fused proteins in vitro. TAT was able to deliver different proteins, such as ... and denaturation of proteins before delivery. In one study, a short amphipathic peptide carrier, Pep-1, and protein complexes ...

*Drosophila embryogenesis

The Nanos protein is a translational repressor protein. Bicoid has a DNA-binding homeodomain that binds both DNA and the nanos ... The Antennapedia group of homeotic selector genes includes labial, antennapedia, sex combs reduced, deformed, and proboscipedia ... Nanos protein forms a gradient at the posterior end. The Bicoid protein blocks translation of caudal mRNA so Caudal protein is ... and Caudal proteins is in the transcriptional regulation of other zygotically expressed proteins. Many of these are the protein ...

*Morphogen

Derossi D, Joliot AH, Chassaing G, Prochiantz A (April 1994). "The third helix of the Antennapedia homeodomain translocates ... These proteins bind to the extracellular domains of transmembrane receptor proteins, which use an elaborate process of signal ... The type I receptors activate Smad proteins that in turn act as transcription factors that regulate gene transcription. Sonic ... However, most morphogens are secreted proteins that signal between cells. A morphogen spreads from a localized source and forms ...

*IKBKG

... consists of the region from T735 to E745 of the IKK-β subunit fused with a sequence derived from the Antennapedia homeodomain ... IKBKG protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NIH/NCBI/UW entry on ... Xiao G, Sun SC (October 2000). "Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein". Oncogene. 19 ... Prajapati S, Verma U, Yamamoto Y, Kwak YT, Gaynor RB (January 2004). "Protein phosphatase 2Cbeta association with the IkappaB ...

*Michael Levine (biologist)

"25 Years of Homeodomain / Homeobox discovery", Evo devo, HOX, May 10, 2008. "Fly Guy". Science Matters. UC Berkeley. 1 (7). ... So McGinnis carved up the Antennapedia gene and, using those pieces as probes, the trio identified eight genes, which turned ... "Synergistic activation and repression of transcription by Drosophila homeobox proteins". Cell. 56 (4): 573-83. doi:10.1016/0092 ... showed a localized pattern of expression similar to that of Antennapedia, they decided to revisit the classic papers of Ed ...
Antennapedia Homeodomain Protein information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
The Antennapedia (Antp) homeotic gene of Drosophila melanogaster controls cell fates and pattern formation in the epidermis, nervous system and mesoderm of thoracic segments. Its expression is controlled at the levels of transcription, alternative RNA splicing, polyadenylation and translation. Two nested Antp transcription units extend over 103 kb and produce sixteen different transcripts. We have compared the Antp genes of Drosophila virilis, Drosophila subobscura and D. melanogaster to determine which structural features are conserved and therefore may be important to the genes function. The overall gene structures are similar. There are many conserved sequence blocks throughout the large introns, at least 15 kb upstream of the first promoter, and at least 3 kb downstream of the last polyadenylation site. Intron and exon sequence conservation around alternative splice sites indicates that alternative protein coding forms may also be conserved. Protein coding potential is perfectly conserved ...
The trithorax (trx) gene is required for normal development of the body plan in Drosophila embryos and adults. Mutations in trx cause homeotic transformations throughout the body. Genetic studies suggest that trx encodes a positive regulatory factor required throughout development for normal expression of multiple homeotic genes of the bithorax and Antennapedia complexes (BX-C and ANT-C). To determine how trx influences homeotic gene expression, we examined the expression of the BX-C genes Ultrabithorax, abdominal-A, Abdominal-B and the ANT-C genes Antennapedia, Sex combs reduced and Deformed in trx embryos. We show that trx does indeed exert its effects by positively regulating homeotic gene expression and that its effects on expression of individual homeotic genes are complex: each of the BX-C and ANT-C genes examined exhibits different tissue-specific, parasegment-specific and promoter-specific reductions in their expression. This implies that each of these genes have different requirements ...
1HOM: Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear magnetic resonance spectroscopy.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Sequence-specific transcription factor which is part of a developmental regulatory system that regulates segmental identity in the mesothorax. Provides cells with specific positional identities on the anterior-posterior axis (By similarity).
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes ...
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes ...
1FTZ: Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain.
Although Hox proteins have fundamental roles in development, researchers have long been puzzled by what creates their binding specificity. Now, Walter Gehring and co-workers add a piece to that puzzle (see p. 1669). The Hox DNA-binding homeodomain has low sequence specificity, and co-factors are thought to contribute to this specificity by binding to a conserved YPWM motif (found in most Hox proteins). Gehrings lab previously demonstrated that ectopic expression of the Drosophila Hox gene Antennapedia (Antp) causes cells of the eye to adopt the developmental fate of the wing. Now they show that YPWM is required for this eye-to-wing transformation and, using a yeast two-hybrid system, have identified a YPWM-binding protein called BIP2. Using gain-of-function experiments and a new bip2 mutant allele, the authors show that the ANTP-BIP2 interaction is required for the ectopic formation of wing structures. BIP2 is a TATA-binding protein associated factor (TAF), making this the first demonstration ...
Generally, all bilaterans examined have similar conservation of HOX protein structure, function, expression, and requirement. However, at the level of being the same, it is unknown whether the HOX protein, Antennapedia, is required for tarsus determination in Drosophila melanogaster as in Tribolium casteneum, or whether the requirement of HOX proteins in determination of body parts diverges in insects. I proposed to use a heat shock-inducible nanobody (UAS- NSlmb-vhhGFP4 driven by hsp-GAL4) activated during the third larval stage in all cells to degrade thoracically expressed HOX proteins (Sex combs reduced, Antennapedia, and Ultrabithorax) tagged with green fluorescence protein (GFP) derivatives; GFP, YFP, CFP, or 17 amino acid epitope of GFP. Due to difficulties in establishing CRISPR mediated homologous recombination, only the initial steps have been completed, but the system is now established to determine whether HOX requirement for tarsus determination is conserved in insects.
Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[1][2][3] In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[3] ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
improved in situ hybridization method for the detection of cellular RNAs in Drosophila tissue sections and its application for localizing transcripts of the homeotic Antennapedia gene complex., An ...
Embryonic, larval, and pupal Antp RNA products of 3.5 and 5kb can be detected. Antennapedia is transcribed from two promoters (P1 and P2) but at least it was not clear in the past whether the protein is produced from P2 transcript (Laughon et al., (1986)). GI:156946 was not studied by IRESite curator in detail yet. The transcript from the P1 promoter has 1512nt long 5-UTR derived from non-coding exons A (55nt), B(88nt), D(252nt), E (621 out of 777nt are coding) and from coding exons F(39nt), G(226nt), H(819nt; note the difference to the H exon of P2 variant below). P1 transcripts are of 3.4 and 4.9kb and appear slightly later than the exon C transcripts (from promoter P2). The 4.9-kb RNA is more abundant than the 3.4-kb species in embryos. Antp transcripts are also found in third-instar larvae and in pupae at about 1/10 of the embryonic levels (Laughon et al., (1986) Fig. 2A). [Laughon et al., (1986)] P1 related GenBank records: complete P1 mRNA record GI:156948, 4694nt long, CDS[1526-2662] DNA ...
Discover the best homework help resource for ANTP at University of Akron. Find ANTP study guides, notes, and practice tests for The University Of Akron.
Penetratin is a 16-residue peptide [RQIKIWFQNRRM KWKK(43-58)]derived from the Antennapedia homeo-domain, which is used as a vector for cellular internalization of hydrophilic molecules. In order to unravel themembrane translocation mechanism, we synthesized new penetratin variants. The contribution of the positively charged residues was studied by double substitutions of Lys and/or Arg resi-dues to Ala, while the specific contribution of Trp48 and Trp56 was studied by individual substitution of these resi-dues to Phe. ... ...
FF domains are found singly or in multiple copies but the number of FF domains in protein sequences ranges, in general, between two and six [1,2,3,4,5,6]. The FF domain is composed of three α-helices arranged in an orthogonal bundle with a 3(10) helix in the loop between the second and third α helices (see ,PDB:1H40,). The two highly conserved phenylalanine residues are in the middle of the first and third α helices, and form part of the hydrophobic core of the protein [3,4,5,6.]. The profile we developed covers the entire FF domain. Last update: June 2013 / First entry. ...
Protein transduction domains (PTDs), both naturally occurring and synthetic, have been extensively utilized for intracellular delivery of biologically active molecules both in vitro and in vivo. However, most comparisons of transduction efficiency have been performed using fluorescent markers. To compare efficiency of functional protein transduction, a peptide derived from IkB kinase ß (IKKß) that prevents formation of an active IKK complex was used as a biologically active cargo. This peptide, termed NEMO Binding Domain (NBD), is able to block activation of the transcriptional factor NF-κB by IKK, but not basal NF-κB activity. Our results demonstrate that Antp and Tat PTDs were most effective for delivery of NBD for inhibition of NF-kB activation compared to other PTD-NBD in both Hela and 293 cells, however, at higher concentrations (100 µM), the Antp-NBD as well as the FGF-NBD peptide caused significant cellular toxicity. In contrast to the cell culture results, delivery of NBD using 8K
There are things to be said about both ways of working. For one, if you leave the type selector off it will decrease the length of your selector which improves the readability of your css file, especially when many selectors are stringed together. Less scrolling sideways is a good thing. On the other hand, adding the type selector does give you extra information on the class and might make it easier to recognize elements as you got the html element to help you out. A more important argument popped up when I was revising our deliverables (our company only does front-end, so we deliver templates to be implemented by partners). Adding the type selector locks the css to the html code. By doing this, you create an extra checkpoint for people to implement the templates you deliver. If, for example, they used an ...
HOXD1 is a protein with a homeobox DNA-binding domain, and it belongs to the Antp homeobox family. This nuclear protein functions as a…
Container and custom selector tests to come later. Log: Unit tests for core selectors, along with some minor bug fixes for problems discovered when writing the tests ...
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First, the model proposes EXD as a required co‐activator for most HOX target elements. All known elements activated in response to HOX proteins also require exd function (Chan et al., 1994, 1996; Rauskolb and Wieschaus, 1994; Popperl et al., 1995; Sun et al., 1995). Based on the phenotypes of exdmz− mutants and of clones of exd mutant cells in adult cuticular structures (Peifer and Wieschaus, 1990; Gonzalez‐Crespo and Morata, 1995; Rauskolb et al., 1995), it seems likely that a great many other HOX target elements also require exd for their activation. The only HOX protein that appears to have some exd‐independent activation function is ABD‐B (Peifer and Wieschaus, 1990). This correlates with the absence of a YPWM motif just upstream of the ABD‐B homeodomain sequence. The YPWM or hexapeptide motif is required for the formation of HOX-EXD or HOX-PBX cooperative binding complexes (Chang et al., 1995; Johnson et al., 1995; Knoepfler and Kamps, 1995; Neuteboom et al., 1995; Phelan et ...
The absence of Antp+ function during embryogenesis results in the larval mesothorax exhibiting characteristics of the prothorax and an ensuing lethality; the loss of Antp+ function in the development of the adult thorax causes specific portions of the leg, wing and humeral imaginal discs to develop abnormally. Every Antp mutation, however, does not cause all of these developmental defects. Certain mutant alleles disrupt humeral and wing disc development without affecting leg development, and they are not deficient for the wild-type function required during embryogenesis. Other Antp mutations result in abnormal legs, but do not alter dorsal thoracic development. Mutations of each type can complement to produce a normal adult fly, which suggests that there are at least two discrete functional units within the locus (Abbott, 1986). Ectopic expression of homeotic genes, Dfd, Scr and Antp, results in the disruption of the developing PNS in the abdomen. Thus homeotic genes have specific roles in ...
attribute of HTML elements in documents that are in quirks mode must be treated as ASCII case-insensitive for the purposes of selector matching.. Attribute and element names of HTML elements in HTML documents must be treated as ASCII case-insensitive for the purposes of selector matching.. Everything else (attribute values on HTML elements, IDs and classes in no-quirks mode and limited-quirks mode, and element names, attribute names, and attribute values in XML documents) must be treated as case-sensitive for the purposes of selector matching.. ...
SpecialChem Selector is the universal selection source for bio-based products and materials. You can contact SpecialChem to get your bio-based products and materials listed on the Selector.
SpecialChem Selector is the universal selection source for bio-based products and materials. You can contact SpecialChem to get your bio-based products and materials listed on the Selector.
Now shooters can quickly transition from rapid fire to ultra-precise long range shot placement with the simple switch of the 3-mode selector.
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I am working through chapter 15 of The Big Nerd Ranch iOS Book 3rd edition, which deals with subclassing table view cells. After creating a custom...
Overloaded. Groups the elements of a sequence according to a specified key selector function and creates a result value from each group and its key. Key values are compared by using a specified comparer, and the elements of each group are projected by using a specified function.(Defined by Enumerable.) ...
We all now recognize that 2016 was a highly unusual year. Political events that we are witnessing today seemed simply impossible 12 months ago.
アメリカ発の洗練されたニュース記事、CNNのWebニュースを読んで英語力をつけよう!TOEIC英語の「語彙・文法」対策になる毎日気軽に読める無料のメルマガ。気になる世界の最新ニュースの情報もキャッチでき、英語学習にもなり一石二鳥です。
アメリカ発の洗練されたニュース記事、CNNのWebニュースを読んで英語力をつけよう!TOEIC英語の「語彙・文法」対策になる毎日気軽に読める無料のメルマガ。気になる世界の最新ニュースの情報もキャッチでき、英語学習にもなり一石二鳥です。
Exploiting Benzophenone Photoreactivity to Probe the Phospholipid Environment and Insertion Depth of the Cell- Penetrating Peptide Penetratin in Model Membranes, Angew Chem Int Ed. 2017 May 9. Penetratin is the third helix of the homeodomain of Antennapedia protein, known to internalize into cells, partly via receptor-independent process, since its reverso, enantio, and retro-inverso peptide analogues are also internalized as cell-penetrating peptides (CPPs). The ability of Penetratin to cause non-cytotoxic cell membrane perturbation now appears as one way to explain its passage across the plasma membrane to reach the cytosol of cells (or internalization), a process in which membrane lipids are key actors. Penetratin also translocates into model membranes (LUV, GUV) and plasma membrane vesicles. Whatever the mechanism of membrane translocation is, lipids are initial contact points for the peptide. Photoactivatable phospholipids have been widely used to study biological systems. The potential of ...
There are several subsets of homeotic genes. They include many of the Hox and ParaHox genes that are important for segmentation.[5] Hox genes are found in bilateral animals, including Drosophila (in which they were first discovered) and humans. Hox genes are a subset of the homeobox genes. The Hox genes are often conserved across species, so some of the Hox genes of Drosophila are homologous to those in humans. In general, Hox genes play a role of regulating expression of genes as well as aiding in development and assignment of specific structures during embryonic growth. This can range from segmentation in Drosophila to central nervous system (CNS) development in vertebrates.[6] Both Hox and ParaHox are grouped as HOX-Like (HOXL) genes, a subset of the ANTP class (named after the Drosophila gene, Antennapedia).[7] They also include the MADS-box-containing genes involved in the ABC model of flower development.[8] Besides flower-producing plants, the MADS-box motif is also present in other ...
During this growth, the expanding brain pulls the prochordal plate (future buccopharyngeal membrane) and the central part of the cardiogenic plate forward, rotating the plate and pericardial part of the intraembryonic coelomic cavity so that the central portions of the cardiogenic plate and pericardial cavity, initially rostral to the buccopharyngeal plate, are now ventral and caudal to ...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Besides being able to target first and last child elements with pseudo-classes, the browser can also target only child elements and empty elements.
Overloaded. Groups the elements of a sequence according to a specified key selector function and creates a result value from each group and its key. Key values are compared by using a specified comparer, and the elements of each group are projected by using a specified function.(Defined by Enumerable.) ...
During animal development, selector genes determine identities of body segments and those of individual organs. Selector genes are also misexpressed in cancers, although their contributions to tumor progression per se remain poorly understood. Using a model of cooperative tumorigenesis, we show that gain of selector genes results in tumor cooperation, but in only select developmental domains of the wing, haltere and eye-antennal imaginal discs of Drosophila larva. Thus, the field selector, Eyeless (Ey), and the segment selector, Ultrabithorax (Ubx), readily cooperate to bring about neoplastic transformation of cells displaying somatic loss of the tumor suppressor, Lgl, but in only those developmental domains that express the homeo-box protein, Homothorax (Hth), and/or the Zinc-finger protein, Teashirt (Tsh ...
User-Agent: Mozilla/5.0 (X11; U; Linux i686; en-US; rv:1.9.3a1pre) Gecko/20100203 Firefox/3.7a1pre Build Identifier: Mozilla/5.0 (X11; U; Linux i686; en-US; rv:1.9.3a1pre) Gecko/20100203 Firefox/3.7a1pre Run the http://www.css3.info/selectors-test/test.html Selector test. Reproducible: Always Steps to Reproduce: 1. Test fails near the end Actual Results: Doesnt pass the checkbox test http://www.css3.info/selectors-test/test-checked.html#checked Expected Results: Pass all the css3 selector ...
Gabriela Cowperthwaite explains why she was motivated as a mother to make the film Blackfish, which airs on CNN Thursday, October 24.
Reconstruction of the endocardium of the heart and its arterial trunks in No. 6520, a member of the median third of stage 17. It is shown in two parts, A and B. In A, only the derivatives of the primary cardiac tube are shown. In B, enough of the primary tube is removed to expose the venous part of the heart. The latter, being in a contracted state, reveals in an unobstructed view the right and left atrioventricular canals, now clearly separated, each leading forward into its respective ventricle. It will be noted that the primary cardiac tube is connected with the venous part of the heart only at the two atrioventricular junctions. When the latter are severed, the arterial portion can be freely separated from the venous part. In A, the cleavage has not yet crossed the crest of the septum, and both arterial trunks lead off from both ventricles. From the distention of the endocardium of the primary cardiac tube, however, one can see that the left ventricle favors the aorta and the right ventricle ...
NYSCF - Robertson Stem Cell Investigator Dr. Paola Arlotta, of Harvard University, published her latest work on gene co-regulation in Nature Neuroscience.. The regulatory logic, or rules, that orchestrate the expression of the unique combinations of genes in each neuron class is unknown. In this study the scientists discovered that Fezf2 is the first selector gene able to regulate on its own the expression of large batteries of genes that collectively define corticospinal motor neurons (CSMN). CSMN are one specific class of cortical neurons responsible for the initiation and fine execution of motor function.These neurons are affected in diseases like ALS and are injured in spinal cord injury.. This is the first discovery of a selector gene for any class of neurons of the cerebral cortex and will aid efforts to program CSMN from stem cells in order to model disease affecting CSMN in vivo.. Read the paper in Nature Neuroscience ,,. ...
Correct identification of individual Hox proteins is an essential basis for their study in diverse research fields. Common methods to classify Hox proteins focus on the homeodomain that characterise homeobox transcription factors. Classification is hampered by the high conservation of this short domain. Phylogenetic tree reconstruction is a widely used but time-consuming classification method. We have developed an automated procedure, HoxPred, that classifies Hox proteins in their groups of homology. The method relies on a discriminant analysis that classifies Hox proteins according to their scores for a combination of protein generalised profiles. 54 generalised profiles dedicated to each Hox homology group were produced de novo from a curated dataset of vertebrate Hox proteins. Several classification methods were investigated to select the most accurate discriminant functions. These functions were then incorporated into the HoxPred program. HoxPred shows a mean accuracy of 97%. Predictions on the
Looking for Homeodomain protein? Find out information about Homeodomain protein. A highly conserved sequence of deoxyribonucleic acid that occurs in the coding region of development-controlling regulatory genes and codes for a protein... Explanation of Homeodomain protein
Cell-penetrating peptides (CPPs) have attracted great interest as delivery vehicles in medicine, with potential for the development of novel therapeutic agents or cosmetic products. Biological membranes are typically impermeable ...
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1. A delay circuit as a multi-stage switching-type delay circuit, comprising multiple stages, each of the stages including: a delay unit; and a selector unit, the delay unit having: a delay unit first input; a delay unit first output connected to the delay unit first input; a delay unit second input; a delay unit second output connected to the delay unit second input; and at least one delay element, each provided between the delay unit first input and the delay unit first output, or between the delay unit second input and the delay unit second output, the selector unit having: a selector unit first input connected to the delay unit first output; a selector unit first output; a selector unit second input; a selector unit second output connected to the delay unit second input; and selectors to switch connections between the selector unit first input and the selector unit second output, between the selector unit second input and the selector unit first output, between the selector unit first input ...
OSD Audio- ISS6 Single Source Speaker Selector with Impedance Protection (6-Zone) (ISS6) The OSD Audio ISS6 Single-Source Speaker Selector with Impedance Protection speaker selector is a powerful audio distribution system that can deliver audio to six zones. Completely flexible and an excellent unit if you plan on expanding later, individual on/off selectors for each listening zone distribute one stereo speaker-level signal to six stereo listening zones. The manual power protection switch engages 10_/15-watt resistors wired in parallel, two per channel. This selector is capable of handling 140 watts per channel total input power without the manual protection engaged and 70 watts per channel with the protection engaged.
Fretz, Marjan & Jin, Jing & Conibere, Robin & Penning, Neal & Al-Taei, Saly & Storm, Gert & Futaki, Shiroh & Takeuchi, Toshihide & Nakase, Ikuhiko & Jones, Arwyn. (2006). Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine. Journal of controlled release : official journal of the Controlled Release Society. 116. 247-54. 10.1016/j.jconrel.2006.07.009 ...
Changes in the set of genes targeted by a conserved selector gene explain the divergence of homologous structures: insect hindwings (a) and vertebrate forelimbs (b). The conserved expression of selector genes Ubx (insect hindwings) and Tbx5 (vertebrate forelimbs) indicates that ancestral forelimbs of vertebrates also expressed these genes and the ancestral hindwings of insects.
i know this has been discussed here before. but, i have to ask, is there any process being made toward fixing the eye dropper color selector? this is one of the most annoying bugs ever. any relief soon? cheers, ray
Arti dan makna apa itu Selector Channel adalah dalam istilah komputer. Kamus, arti dan daftar istilah komputer lengkap dari berbagai sumber terpercaya.
Following reports that Dr. Sanjay Gupta misreported who he performed brain surgery on in Nepal and subsequently had an online report changed to reflect his version of the story, the editor-in-chief of CNN Digital Meredith Artley spoke to Erik Wemple of the Washington Post, calling the situation absolutely regrettable. In a statement, CNN expressed its…
This Fork its for using HTMLElements instead of string selectors in ScrollContainer property, which that means that you can pass Elements that are not reachable by selectors such as Elements inside Shadow Dom. ...
All of your content goes in this div. This section is fluid so that if the window is collapsed, your div will collapse also and fit the screen perfectly. To change the properties of this div you can change the #center selector in the style sheet that is located on this page between the head tags ...
Join Lee Lanier for an in-depth discussion in this video Creating the motion path reference, part of VFX Techniques: Space Scene 01 Maya Animation and Dynamic Simulation
The present study was undertaken to analyse the capability of HIV-1 derived TAT protein transduction domain (PTD) fused with Green Fluorescent Protein (TAT-GFP) as a delivery vehicle into a range of protozoan parasites. Successful transduction of native purified TAT-GFP was observed by fluorescent microscopy in Cryptosporidium parvum, Giardia duodenalis, and Neospora caninum. The ability to transduce peptides and other cargo into protozoan parasites, will greatly assist in the delivery of future peptide-based drugs and target validation peptides.. ...
Quantitative fluorescence spectroscopy and flow cytometry analyses of cell-penetrating peptides internalization pathways: optimization, pitfalls, comparison with mass spectrometry quantification, Scientific Reports 6, 36938 (2016). Since their discovery twenty years ago, cell-penetrating peptides (CPPs) or protein transduction domains (PTDs) have been described as promising drug delivery systems. There are increasing numbers of successful applications of CPPs/PTDs in vivo. However, one of the limitations to their wide and diverse application is the diversity of their uptake pathways. The CPP and its cargo may end up free in the cytosol and reach their biological target only following translocation, but remain confined in intracellular vesicles after endocytosis, unless subsequent events such as endosomal rupture occur. Along with the development of CPPs/PTDs as vectors to carry various macromolecules for targeted cellular therapies, engineering new CPPs/PTDs with optimized transport and ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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0172] According to various embodiments, multi-RAT terminal 800 is configured to transmit real-time positional information corresponding to its location to an iRAN, such as RAN 101a, and, more specifically, to RAN selector 111, for determining one or more RANs accessible by terminal 800. In other embodiments, real-time positioning information may be ported to RAN selector 817 for this purpose. Additionally (or alternatively), location module 809 may be configured to determine those RANs accessible by terminal 800 based on one or more coverage areas stored to, for example, memory 811 or any other suitable storage location of system 100, such as load information repository 115. Accordingly, location module 809 may transmit or port those RANs accessible by terminal 800 to RAN selector 111 and/or RAN selector 817. In return, RAN selector 111 or 817 may provide terminal 800 with a list of candidate RANs capable of supporting a requested application service (requested by a user of terminal 800) or a ...
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Protesters lined Huckabees Iowa campaign quarters Monday. DES MOINES, Iowa (CNN) - -- Anti-war protestors and Ron Paul supporters both kept Mike Huckabee from entering his Iowa campaign headquarters through the front door Monday.
Editors note: This post is part of the Overheard on CNN.com series, a regular feature that examines interesting comments and thought-provoking conversations posted by the community.
Well organized and easy to understand Web building tutorials with lots of examples of how to use HTML, CSS, JavaScript, SQL, PHP, and XML.
The Nigerian Senate demanded updates from the nations security agencies on attempts to rescue girls abducted from Chibok two years ago.
Deformable Part Models with CNN Features Pierre-André Savalle 1, Stavros Tsogkas 1,2, George Papandreou 3, Iasonas Kokkinos 1,2 1 Ecole Centrale Paris, 2 INRIA, 3 TTI-Chicago Abstract. In this work we
It all began with you. Starting last November 26th, at the conclusion of last years "CNN Heroes: An All-Star Tribute," we invited viewer nominations for 2010 CNN Heroes to be submitted through our website, at CNNHeroes.com. By the close of nominations on August 1, we had received more than 10,000 of them from 100 countries, a new record for the CNN Heroes campaign. This is a testament to how much stories like these matter to you.. Our CNN Heroes staff read each and every nomination, selecting more than two dozen individuals as 2010 CNN Heroes. Their stories aired weekly on CNN, HLN, CNN International, CNN en Español and CNN.com, between January and September.. A group of CNN judges further reviewed this years CNN Heroes, evaluating their accomplishment, impact, and personal motivation for service to others. Twenty individuals were advanced to an independent Blue Ribbon Panel, which was asked to select the ten individuals we honor as the Top 10 CNN Heroes of 2010. Each of these ten will ...
node_idx = REST::Neo4p::Index-,new(node, my_node_index); $rel_idx = REST::Neo4p::Index-,new(relationship, my_rel_index); $fulltext_idx = REST::Neo4p::Index-,new(node, my_ft_index, { type =, fulltext, provider =, lucene }); $node_idx-,add_entry( $ShaggyNode, pet =, ScoobyDoo ); $node_idx-,add_entry( $ShaggyNode, pet =, ScoobyDoo, species =, Dog, genotype =, ScSc, episodes_featured =, 2343 ); @returned_nodes = $node_idx-,find_entries(pet =, ScoobyDoo); @returned_nodes = $node_idx-,find_entries(pet:Scoob*); $node_idx-,remove_entry( $JosieNode, hair =, red ...
HTH motifs are common in bacterial Clomid tamoxifeno tpc proteins, and are found embedded in eukaryotic homeodomains. 100 в 94 0 в 6 94 в 60 6 в 40 60 в 0 40 в 100 0 100 tamoxifen spectrophotometer at 205 nm. 2. Roszak, T.
In the To field, type a user name, then press Enter. Repeat for additional users. Include any resource IDs (such as conference rooms) in the To field. If necessary, type user names in the CC and BC fields.. or. To select user names or resources from a list, click Address on the toolbar to use the Address Selector to add users. For more information on how to use the Address Selector, see Section 6.2, Using the Address Selector.. Your name is automatically added to the To field of the appointment. When you send the appointment, it is automatically added to your calendar. If you do not want to be included in the message, delete your name from the To field. ...
Editors note: This post is part of the Overheard on CNN.com series, a regular feature that examines interesting comments and thought-provoking conversations posted by the community. Weve known for some time that the U.S. Postal Service has been struggling in the Internet age.
A time and money saving of 50%, or greater, in the prototyping and testing steps of the project... further money savings during the item lifetime.
Use this Random Tangle Selector with your TanglePatterns.com TANGLE GUIDE to help you select tangles. See Pages 7 and 9 of the Guide for instructions. You can also use this to select random Strings.. ...
Use this Random Tangle Selector with your TanglePatterns.com TANGLE GUIDE to help you select tangles. See Pages 7 and 9 of the Guide for instructions. You can also use this to select random Strings.. ...
acgttcgttc gatggcaacg gattggataa caggcgcgcg ctttgtttta ttatccacat tatcagctgc attattgtta ttattggccc tcagcgcttt ^1 ^11 ^21 ^31 ^41 ^51 ^61 ^71 ^81 ^91 accgctcgcc cacgcgtccg cccgtgaatg ccgcgcggaa aagtcgcttt ccactagatt ggcgtccaga ttcgaggaaa tccgtcagca gacgcattcg ^101 ^111 ^121 ^131 ^141 ^151 ^161 ^171 ^181 ^191 cgcccgttcg gtcagcacta tggctaataa tcgttcaaat cgttaaaacc ataaaaataa taataataat tgcaataaca ataaacatag taataatcgt ^201 ^211 ^221 ^231 ^241 ^251 ^261 ^271 ^281 ^291 aacgcttacg agcctttgat agtgccaagg caagcgcaat ccaagtattc aaattcgaat tcaattaaca gcaaagtgca attggctaaa aaccgaaacc ^301 ^311 ^321 ^331 ^341 ^351 ^361 ^371 ^381 ^391 aaaacgcaac aaagtatacg aaacacttgt gaaaccgtac aaacaattgt ggaaaaaaat ttaaagatta ttaagattga agtctcaata aacattagtg ^401 ^411 ^421 ^431 ^441 ^451 ^461 ^471 ^481 ^491 cttaaataaa tttaaaacga cccgcgtgga gagtgcaata aaaagaataa cttttgaaat aaatatttac caaacagaaa aatattttat aaatatttaa ^501 ^511 ^521 ^531 ^541 ^551 ^561 ^571 ^581 ^591 ataagtgaaa aacaaattgg ttactctgaa acaaagaaaa ttcaaattgg ...
Peptides characterized as protein transduction domain peptides (PTD) or membrane transduction peptides (MTP) have recently attracted attention as a novel approach for the efficient intracellular delivery of oligopeptides, oligonucleotides and other bioactive macromolecules, primarily into the cytoplasm of mammalian cells. However, the effect of the linkage between cargo and its cationic oligopeptide carrier on the internalization, intracellular processing and biological activity of the cargo has not been fully deliberated. In this thesis, the cellular processing of conjugates of PTDs and the nuclear encoded apoptotic protein cytochrome c prepared with either a disulfide or a thioether linkage is studied and the conjugates used as a tool to learn more about the intracellular fate of cationic oligopeptides. The results from this work, performed in multiple cell lines, including CHO, U937 and HeLa, show that the uptake of the conjugates is increased when compared to that of cytochrome c alone. In ...
Transcription factor which acts with the selector homeodomain proteins altering the regulation of downstream target genes such as wingless (wg), teashirt (tsh) and decapentaplegic (dpp), thus affecting segmental identity. Delimits the eye field and prevent inappropriate eye development. Required for proper localization of chordotonal organs within the peripheral nervous system (By similarity).
2008) In vitro analysis of the TAT protein transduction domain as a drug delivery vehicle in protozoan parasites. Experimental Parasitology, 118 (3). pp. 303-307. Jefferies, R., Down, J., McInnes, L., Ryan, U., Robertson, H., Jakob-Hoff, R. and Irwin, P. ...
Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
[cnn-photo-caption image= http://i2.cdn.turner.com/cnn/2010/images/03/29/art.ksjkusa0329.cnn.jpg caption=We intend to follow the law, HHS Secretary Kathleen Sebelius said Monday on CNN.
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Opinion by Chris Stedman, special to CNN (CNN) - Conservative atheist and television pundit S.E. Cupp has come out swinging against progressive atheists. In a clip (see above) for CNNs
On a wicket that helped seamers, Praveen, 21, literally made the batsmen dance to his tune with the second new ball, feels Amol Karhadkar.
April 3 (Reuters) - Five people have been arrested in connection with an attack on a Kenyan university that killed at least 148 people, CNN reported on Frida...
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With both of his major rivals injured, Marc Marquez has a chance to take the lead in the MotoGP standings after the German Grand Prix.
Researchers have shown, for the first time, that reduced dietary potassium promotes elevated aortic stiffness in a mouse model. Such arterial stiffness in humans is predictive of heart disease and death from heart disease, and it represents an important health problem for the nation.
Delivering peptide-based drugs to the brain is a major challenge because of the existence of the blood-brain barrier (BBB). To overcome this problem, cell-penetrating peptides derived from proteins that are able to cross biological membranes have been used as cell-permeable and brain-penetrant compounds. An example is the transactivator of transcription protein transduction domain (Tat) of the human immunodeficiency virus. The basic domain of Tat is formed of arginine and lysine amino acid residues. Tat has been used as brain-penetrant carrier also in therapies for Alzheimer disease (AD), the most common form of dementia characterized by extracellular cerebral deposits of amyloid made up of Aβ peptide ...
The head bears two pairs of antennae, the first of which is often biramous (branching into two parts) and the second pair bear exopods (outer branches) which are often flattened into antennal scales known as scaphocerites.[7] The mouthparts consist of pairs each of mandibles, maxillules (second pair of mouthparts) and maxillae. Usually a pair of stalked compound eyes is present, although in some taxa the eyes are unstalked, reduced or lost.[9][10]. Up to three thoracic segments may be fused with the head to form a cephalothorax; the associated appendages turn forward and are modified as maxillipeds (accessory mouthparts).[7] A carapace may be absent, present or secondarily lost, and may cover the head, part or all of the thorax and some of the abdomen.[6] It is variable in form and may be fused dorsally with some of the thoracic segments or occasionally be in two parts, hinged dorsally.[9] Typically, each of the thoracic appendages is biramous and the endopods are the better developed of the ...
Biology. Dupont & Roepke (1941) stated the larva to be green or greyish brown in Java, the horn less recurved than in lachesis. In India the green form is much commoner than yellow or brown forms (Bell & Scott, 1937); the thoracic segments are yellower than the rest, the coloration similar to that of lachesis. In India the green form is much commoner than yellow or brown forms (Bell & Scott, 1937); the thoracic segments are yellower than the rest, the coloration similar to that of lachesis ...

Antennapedia Homeodomain Protein - RightDiagnosis.comAntennapedia Homeodomain Protein - RightDiagnosis.com

Antennapedia Homeodomain Protein information including symptoms, causes, diseases, symptoms, treatments, and other medical and ... Description of Antennapedia Homeodomain Protein. Antennapedia Homeodomain Protein: Antennapedia homeodomain protein is a ... Antennapedia Homeodomain Protein: Related Topics. These medical condition or symptom topics may be relevant to medical ... information for Antennapedia Homeodomain Protein: *Homeodomain *Protein Interesting Medical Articles:. *Symptoms of the Silent ...
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Homeodomain Proteins
      - Proteins, Homeobox
     Summary Report | CureHunterHomeodomain Proteins - Proteins, Homeobox Summary Report | CureHunter

... that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are ... Homeodomain Proteins: Proteins encoded by homeobox genes (GENES, HOMEOBOX) ... Antennapedia Homeodomain Protein: 3. *cone rod homeobox protein: 3. *homeobox protein HOXA9: 3 ... Proteins, Homeobox; Homeo Domain Proteins; Homeotic Proteins; Proteins, Homeo Domain; Proteins, Homeodomain; Proteins, Homeotic ...
more infohttp://www.curehunter.com/public/keywordSummaryD018398-Homeodomain-Proteins-Proteins--Homeobox.do

Structure Cluster 









- 1HOM: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM...Structure Cluster - 1HOM: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM...

Determination of the three-dimensional structure of the Antennapedia homeodomain from Drosophila in solution by 1H nuclear ... Description: ANTENNAPEDIA PROTEIN protein , Length: 68 No structure alignment results are available for 1HOM.A explicitly.. It ... DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR ... Pre-calculated protein structure alignments at the RCSB PDB website. Bioinformatics 26: 2983-2985 ...
more infohttp://www.rcsb.org/pdb/explore/structureCluster.do?structureId=1HOM

Antp - Homeotic protein antennapedia - Drosophila subobscura (Fruit fly) - Antp gene & proteinAntp - Homeotic protein antennapedia - Drosophila subobscura (Fruit fly) - Antp gene & protein

cd00086. homeodomain. 1 hit. Gene3D Structural and Functional Annotation of Protein Families ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS00032. ANTENNAPEDIA. 1 hit. PS00027. ... PROSITE; a protein domain and family database. More...PROSITEi. View protein in PROSITE. PS00032. ANTENNAPEDIA. 1 hit. PS00027. ... Protein. Similar proteins. Organisms. Length. Cluster ID. Cluster name. Size. Q24645. P02833. A4V2I6. I5AP85. B4GEM0. B4NAA8. ...
more infohttp://www.uniprot.org/uniprot/Q24645

Comparative studies of Drosophila Antennapedia genes. | GeneticsComparative studies of Drosophila Antennapedia genes. | Genetics

Protein coding potential is perfectly conserved around the C-terminal homeodomain, well conserved in the N-terminal region, and ... Comparative studies of Drosophila Antennapedia genes.. J E Hooper, M Pérez-Alonso, J R Bermingham, M Prout, B A Rocklein, M ... Comparative studies of Drosophila Antennapedia genes.. J E Hooper, M Pérez-Alonso, J R Bermingham, M Prout, B A Rocklein, M ... Comparative studies of Drosophila Antennapedia genes.. J E Hooper, M Pérez-Alonso, J R Bermingham, M Prout, B A Rocklein, M ...
more infohttp://www.genetics.org/content/132/2/453

HomeoDB: Homeobox DatabaseHomeoDB: Homeobox Database

Gnot1 homeodomain protein. Noto. Chicken. HHEX. hematopoietically expressed homeobox. Hhex. Chicken. HMX1. H6 family homeobox 1 ... The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the ...
more infohttp://homeodb.zoo.ox.ac.uk/family_info.get?spf=t&spfm=ANTP&sbfm=&og=Chicken

Antennapedia - WikipediaAntennapedia - Wikipedia

Antennapedia Homeodomain Protein at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Antennapedia ... Antennapedia is a HOM-C gene first discovered in Drosophila which controls the formation of legs during development. Loss-of- ... Antennapedia also refers to a gene complex in Drosophila which is responsible for formation and differentiation of the thoracic ... It is suggested that Antennapedia arose from Evx, a non-Hox family of genes. This duplication event of Evx into the Antp-class ...
more infohttps://en.wikipedia.org/wiki/Antennapedia

Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide....Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide....

A 16 amino-acid peptide from the third helix of the Antennapedia homeodomain protein has recently been shown to be able to act ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8805278?dopt=Abstract

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry (v.3, #2) | www.chemweb.comBiochemistry (Moscow), Supplement Series B: Biomedical Chemistry (v.3, #2) | www.chemweb.com

Keywords: blood-brain barrier; transport; Drosophila melanogaster ; Antennapedia homeodomain; penetratin; protein transduction ... derived from a Drosophila Antennapedia homeodomain protein can cross Drosophila and deliver the apoE mimetic peptide exhibiting ... The Q parameter representing the ratio of protein-protein complex lifetime (τ lT ) to time required for a single hydroxylation ... The phenomenon of protein transduction represents internalization of short peptides known as protein transduction domains (PTD ...
more infohttps://chemweb.com/articles/SV11828/0000300002

p53 Activator, Cell-Permeable | 506131p53 Activator, Cell-Permeable | 506131

This peptide is linked to a sequence from the third helix of the Drosophila Antennapedia homeodomain protein to allow cell- ... This peptide is linked to a sequence from the third helix of the Drosophila Antennapedia homeodomain protein to allow cell- ... Binds mutant p53 and restores the growth suppressor functions of p53 protein in human tumor cells. Induces apoptosis in human ... Binds mutant p53 and restores the growth suppressor functions of p53 protein in human tumor cells. Induces apoptosis in several ...
more infohttp://www.merckmillipore.com/INTL/en/product/p53-Activator-Cell-Permeable,EMD_BIO-506131

Viral Vector Mediation for Gene Therapy: An Immunological Overview - Journal of Young InvestigatorsViral Vector Mediation for Gene Therapy: An Immunological Overview - Journal of Young Investigators

Several of these proteins are known to exist, including the TAT protein of HIV, the antennapedia homeodomain protein from ... Use of the VP22 protein showed an increase in expression of the protein and also in distribution of the protein, indicating ... Adenoviral vectors naturally express the capability of lysing cells through a protein labeled the adenovirus death protein ( ... 2005). Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.J ...
more infohttps://www.jyi.org/2009-february/2017/10/7/viral-vector-mediation-for-gene-therapy-an-immunological-overview

HOXB7 - WikipediaHOXB7 - Wikipedia

"Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain". Blood. 78 (4): 1047-55. PMID ... Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene. This gene is a member of the Antp homeobox ... "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". ... "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663-74. ...
more infohttps://en.wikipedia.org/wiki/HOXB7

Searle Scholars Program : Cynthia J. Kenyon (1986)Searle Scholars Program : Cynthia J. Kenyon (1986)

Clusters of genes encoding Antennapedia-class homeodomain proteins (Hox proteins) have been conserved between flies and ... The migratory behaviors of the Q descendants are influenced by the activities of Hox genes, which encode homeodomain proteins ... One protein involved in Hox gene regulation is pal-1, a homolog of the Drosophila caudal gene. These homologs are required for ... In some cells, the Antennapedia homolog mab-5 is also kept off by cell-cell interactions. If the neighbors of V5 are ablated, ...
more infohttps://searlescholars.net/person/359

The role of the 5 untranslated region of an mRNA in translation regulation during development.  - PubMed - NCBIThe role of the 5' untranslated region of an mRNA in translation regulation during development. - PubMed - NCBI

Antennapedia Homeodomain Protein. *DNA-Binding Proteins. *Drosophila Proteins. *Endothelial Growth Factors. *Eukaryotic ... and homeodomain proteins. A number of these mRNAs use an alternative mechanism of translation initiation, involving an internal ... Ubx RAR beta 2 c-mos and c-myc regulate protein expression in a spatio-temporal manner. Translation initiation on a number of ... These characteristics are often found in mRNAs encoding regulatory proteins like proto-oncogenes, growth factors, their ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/10216946?dopt=Abstract

The import of peptides into lymphocytes and their effects on the cell cycle  : Sussex Research OnlineThe import of peptides into lymphocytes and their effects on the cell cycle : Sussex Research Online

We have investigated the cellular import of the third helix of the antennapedia homeodomain protein as an alternative method ... of the surviving cells express the desired protein. In addition, quiescent primary lymphocytes require partial activation for ...
more infohttp://sro.sussex.ac.uk/16779/

Biological targeting compositions and methods of using the same - Patent applicationBiological targeting compositions and methods of using the same - Patent application

... the Drosophila Antennapedia homeodomain protein, the herpes simplex-1 virus VP22 protein, and transportin, a fusion between the ... Alternatively, a specific protein may be labeled with VT680. In some instances, an antibody directed against a specific protein ... Plasmid DNA encoding the protein or proteins of interest is incubated with branched or linear PEIs varying in size from 0.8 K ... Viral nucleocapsid protein as a multifunctional translation initiation factor and increased protein and polypeptide production ...
more infohttp://www.patentsencyclopedia.com/app/20100041133

Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in drosophilaProtein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in drosophila

Keywords: blood-brain barrier, transport, Drosophila melanogaster, Antennapedia Homeodomain, penetratin, protein transduction ... derived from a Drosophila Antennapedia homeodomain protein, is capable of crossing the BBB in Drosophila while carrying a cargo ... Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in drosophila. ... Protein transduction domain (PTD)-peptides greatly facilitate the delivery of high molecular weight macromolecules across the ...
more infohttp://pbmc.ibmc.msk.ru/en/article-en/PBMC-2009-55-1-41/

Repressor Proteins | Harvard Catalyst Profiles | Harvard CatalystRepressor Proteins | Harvard Catalyst Profiles | Harvard Catalyst

Adenovirus E1B Proteins. *Antennapedia Homeodomain Protein. *AraC Transcription Factor. *Basic Helix-Loop-Helix Transcription ... Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ... "Repressor Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Repressor Proteins" by people in Harvard Catalyst Profiles by ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/Repressor%20Proteins

Experts and Doctors on drosophila melanogaster in New York, United StatesExperts and Doctors on drosophila melanogaster in New York, United States

antennapedia homeodomain protein*armadillo domain proteins*casein kinase iepsilon*blastoderm*odorant receptors*olfactory ... Amrein H, Hedley M, Maniatis T. The role of specific protein-RNA and protein-protein interactions in positive and negative ... These results demonstrate that both protein-RNA and protein-protein interactions are involved in tra2-dependent activation and ... Mika S, Rost B. Protein-protein interactions more conserved within species than across species. PLoS Comput Biol. 2006;2:e79 ...
more infohttp://www.labome.org/locale/united/experts-and-doctors-on-drosophila-melanogaster-in-new-york--united-states-15159.html

SOX Transcription Factors | Harvard Catalyst Profiles | Harvard CatalystSOX Transcription Factors | Harvard Catalyst Profiles | Harvard Catalyst

Adenovirus E1B Proteins. *Antennapedia Homeodomain Protein. *AraC Transcription Factor. *Basic Helix-Loop-Helix Transcription ... originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. ... numerous members of this family are organized in several subgroups according to structural identities found within the proteins ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/SOX%20Transcription%20Factors

Experts and Doctors on  in United StatesExperts and Doctors on in United States

antennapedia homeodomain protein*ehrlichia chaffeensis*proprotein convertase 2*hydroxymethylglutaryl coa reductases*crown rump ... wnt1 protein*tribolium*neuregulins*butterflies*gryllidae*auxilins*insect hormones*clathrin heavy chains*embryonic structures* ... We conclude that shn function is critical for cells to respond properly to dpp and propose that shn protein is the first ... Experts and Doctors on drosophila proteins in United States*Experts and Doctors on animals in United States*Experts and Doctors ...
more infohttp://www.labome.org/locale/experts-and-doctors-on-in-united-states-22015.html

Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation | DevelopmentCdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation | Development

... amino acid sequence identity with the homeodomain of Antennapedia class proteins (Antp) and the two also partially share a ... It encodes a protein of which the homeodomain shares approximately 50% ... Interactions between Cdx proteins and Hox genes may go on in areas of co-expression in the unsegmented paraxial mesoderm ... We examined expression of the Hoxb8βgal knock in fusion protein in Cdx mutants at stages when Hoxb8 expression is still in the ...
more infohttps://dev.biologists.org/content/129/9/2181?ijkey=85142e7ab819f56fc2526437f7251caef066ce7f&keytype2=tf_ipsecsha

Optic Nerve Diseases - RightDiagnosis.comOptic Nerve Diseases - RightDiagnosis.com

Antennapedia Homeodomain Protein *Antepartal *Antepartum *Antepartum diagnosis *Antepartum hemorrhage *Antepartum hemorrhage ...
more infohttp://www.rightdiagnosis.com/medical/optic_nerve_diseases.htm

Fushi Tarazu Transcription Factors | Profiles RNSFushi Tarazu Transcription Factors | Profiles RNS

Adenovirus E1B Proteins. *Antennapedia Homeodomain Protein. *AraC Transcription Factor. *Basic Helix-Loop-Helix Transcription ... The mesoderm determinant snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis. EMBO J. 1999 ...
more infohttps://profiles.umassmed.edu/display/105737
  • Repressor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The attachment of a virion particle with the surface of an individual cell is based upon the interaction between cell surface receptors and the particles composing the capsid or proteins on the surface of the virion. (jyi.org)
  • High-grade tumor-related proteins have been analyzed as potential targets for radiolabeled antibodies. (chemweb.com)
  • The numerous members of this family are organized in several subgroups according to structural identities found within the proteins. (harvard.edu)
  • Insertion of exogenous ubiquitin into rat brain mitochondria in the presence of ATP and the ATPregenerating system (creatine phosphate/creatine phosphokinase) results in the increase in: sensitivity of mitochondrial monoamine oxidases (MAO) A and B to inhibition by mechanism based inhibitor and incorporation of [ 3 H]-pargyline, which was especially notable in the fraction obtained by immunoprecipitation of mitochondrial proteins with anti-ubiquitin antiserum and protein A Sepharose. (chemweb.com)
  • This graph shows the total number of publications written about "Repressor Proteins" by people in Harvard Catalyst Profiles by year, and whether "Repressor Proteins" was a major or minor topic of these publication. (harvard.edu)
  • Below are the most recent publications written about "Repressor Proteins" by people in Profiles. (harvard.edu)
  • between 1% and 10% of the surviving cells express the desired protein. (sussex.ac.uk)
  • We suggest that endocytosis into delta-expressing cells of NotchECD bound to delta plays a critical role during activation of the Notch receptor and is required to achieve processing and dissociation of the Notch protein. (labome.org)