Carnosine stimulates vimentin expression in cultured rat fibroblasts. (1/24)

Two-dimensional electrophoretic gel profiles were compared between rat 3Y1 fibroblasts cultured in the presence and absence of 30 mM L-carnosine (beta-alanyl-L-histidine) for one week without any replenishment of medium. While a number of cellular proteins changed their expression levels by the addition of carnosine, we identified one of the most prominently varied proteins as vimentin. Immunoblot analysis with anti-vimentin antibody demonstrated that the vimentin levels increased about 2-fold after one-week culture in the presence of carnosine. We also confirmed that the increase of vimentin expression was dependent on the concentration of carnosine added to the medium. Moreover, when cultured cells were stained with anti-vimentin antibody and observed by light microscopy, most cells grown in the presence of carnosine were found to have markedly developed vimentin filaments. The increase of vimentin expression was also observed by adding with carnosine related dipeptides, N-acetylcarnosine and anserine.  (+info)

Hydrogen peroxide-mediated Cu,Zn-superoxide dismutase fragmentation: protection by carnosine, homocarnosine and anserine. (2/24)

The fragmentation of human Cu,Zn-superoxide dismutase (SOD) was observed during incubation with H(2)O(2). Hydroxyl radical scavengers such as sodium azide, formate and mannitol protected the fragmentation of Cu,Zn-SOD. These results suggested that *OH was implicated in the hydrogen peroxide-mediated Cu,Zn-SOD fragmentation. Carnosine, homocarnosine and anserine have been proposed to act as anti-oxidants in vivo. We investigated whether three compounds could protect the fragmentation of Cu,Zn-SOD induced by H(2)O(2). The results showed that carnosine, homocarnosine and anserine significantly protected the fragmentation of Cu,Zn-SOD. All three compounds also protected the loss of enzyme activity induced by H(2)O(2). Carnosine, homocarnosine and anserine effectively inhibited the formation of *OH by the Cu,Zn-SOD/H(2)O(2) system. These results suggest that carnosine and related compounds can protect the hydrogen peroxide-mediated Cu,Zn-SOD fragmentation through the scavenging of *OH.  (+info)

A re-evaluation of the antioxidant activity of purified carnosine. (3/24)

The antioxidant activity of carnosine has been re-evaluated due to the presence of contaminating hydrazine in commercial carnosine preparations. Purified carnosine is capable of scavenging peroxyl radicals. Inhibition of the oxidation of phosphatidylcholine liposomes by purified carnosine is greater in the presence of copper than iron, a phenomenon likely to be due to the copper chelating properties of carnosine. Purified carnosine is capable of forming adducts with aldehydic lipid oxidation products. Adduct formation is greatest for alpha,beta-monounsaturated followed by polyunsaturated and saturated aldehydes. While the ability of carnosine to form adducts with aldehydic lipid oxidation products is lower than other compounds such as glutathione, the higher concentrations of carnosine in skeletal muscle are likely to make it the most important molecule that forms aldehyde adducts. Monitoring changes in carnosine concentrations in oxidizing skeletal muscle shows that carnosine oxidation does not occur until the later stages of oxidation suggesting that carnosine may not be as effective free radical scavenger in vivo as other antioxidants like alpha-tocopherol.  (+info)

Effect of carnosine and related compounds on the inactivation of human Cu,Zn-superoxide dismutase by modification of fructose and glycolaldehyde. (4/24)

Glycolaldehyde, an intermediate of the Maillard reaction, and fructose, which is mainly derived from the polyol pathway, rapidly inactivate human Cu,Zn-superoxide dismutase (SOD) at the physiological concentration. We employed this inactivation with these carbonyl compounds as a model glycation reaction to investigate whether carnosine and its related compounds could protect the enzyme from inactivation. Of eight derivatives examined, histidine, Gly-His, carnosine and Ala-His inhibited the inactivation of the enzyme by fructose (p<0.001), and Gly-His, Ala-His, anserine, carnosine, and homocarnosine exhibited a marked protective effect against the inactivation by glycolaldehyde (p<0.001). The carnosine-related compounds that showed this highly protective effect against the inactivation by glycolaldehyde had high reactivity with glycolaldehyde and high scavenging activity toward the hydroxyl radical as common properties. On the other hand, the carnosine-related compounds that had a protective effect against the inactivation by fructose showed significant hydroxyl radical-scavenging ability. These results indicate that carnosine and such related compounds as Gly-His and Ala-His are effective anti-glycating agents for human Cu,Zn-SOD and that the effectiveness is based not only on high reactivity with carbonyl compounds but also on hydroxyl radical scavenging activity.  (+info)

Protection by carnosine-related dipeptides against hydrogen peroxide-mediated ceruloplasmin modification. (5/24)

Carnosine, homocarnosine, and anserine are present in high concentrations in the muscle and brain of many animals and humans. Previous studies showed that these compounds have an antioxidant function. We investigated the protective effects of carnosine and related compounds on the modification of human ceruloplasmin that is induced by H2O2. Carnosine, homocarnosine, and anserine significantly inhibited the fragmentation and inactivation of ceruloplasmin that is induced by H2O2. All three compounds also inhibited the release of copper ion from protein, and the formation of hydroxyl radicals in the ceruloplasmin/H2O2 system. These compounds inhibited the fragmentation of human serum albumin that is induced by the copper-catalyzed oxidation system, as well as by the iron-catalyzed oxidation system. These results suggest that carnosine, homocarnosine, and anserine might protect ceruloplasmin against H2O2-mediated oxidative damage through a combination of copper chelation and free radical scavenging.  (+info)

Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification. (6/24)

Carnosine (beta-alanyl-L-histidine), homocarnosine (gamma-amino-butyryl-L-histidine) and anserine (beta-alanyl-1-methyl-L-histidine) have been proposed to act as anti-oxidants in vivo. The protective effects of carnosine and related compounds against the oxidative damage of human Cu,Zn-superoxide dismutase (SOD) by peroxyl radicals generated from 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) were studied. The oxidative damage to Cu,Zn-SOD by AAPH-derived radicals led to protein fragmentation, which is associated with the inactivation of enzyme. Carnosine, homocarnosine and anserine significantly inhibited the fragmentation and inactivation of Cu,Zn-SOD by AAPH. All three compounds also inhibited the release of copper ions from the enzyme and the formation of carbonyl compounds in AAPH-treated Cu,Zn-SOD. These compounds inhibited the fragmentation of other protein without copper ion. The results suggest that carnosine and related compounds act as the copper chelator and peroxyl radical scavenger to protect the protein fragmentation. Oxidation of amino acid residues in Cu,Zn-SOD induced by AAPH were significantly inhibited by carnosine and related compounds. It is proposed that carnosine and related dipeptides might be explored as potential therapeutic agents for pathologies that involve Cu,Zn-SOD modification mediated by peroxyl radicals.  (+info)

Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification. (7/24)

Ceruloplasmin (CP) is the major plasma antioxidant and copper transport protein. In a previous study, we showed that the aggregation of human ceruloplasmin was induced by peroxyl radicals. We investigated the effects of antioxidant dipeptides carnosine, homocarnosine and anserine on peroxyl radical-mediated ceruloplasmin modification. Carnosine, homocarnosine and anserine significantly inhibited the aggregation of CP induced by peroxyl radicals. When CP was incubated with peroxyl radicals in the presence of three compounds, ferroxidase activity, as measured by the activity staining method, was protected. All three compounds also inhibited the formation of dityrosine in peroxyl radicals-treated CP. The results suggest that carnosine and related compounds act as peroxyl radical scavenger to protect the protein modification. It is proposed that carnosine and related peptides might be explored as potential therapeutic agents for pathologies that involve CP modification mediated by peroxyl radicals generated in the lipid peroxidation.  (+info)

Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system. (8/24)

The alpha-synuclein is a major component of Lewy bodies that are found in the brains of patients with Parkinson's disease (PD). Also, two point mutations in this protein, A53T and A30P, are associated with rare familial forms of the disease. We investigated whether there are differences in the Cu,Zn-SOD and hydrogen peroxide system mediated-protein modification between the wild-type and mutant alpha-synucleins. When alpha-synuclein was incubated with both Cu,Zn-SOD and H2O2, then the amount of A53T mutant oligomerization increased relative to that of the wild-type protein. This process was inhibited by radical scavenger, spin-trapping agent, and copper chelator. These results suggest that the oligomerization of alpha-synuclein is mediated by the generation of the hydroxyl radical through the metal-catalyzed reaction. The dityrosine formation of the A53T mutant protein was enhanced relative to that of the wild-type protein. Antioxidant molecules, carnosine, and anserine effectively inhibited the wild-type and mutant proteins' oligomerization. Therefore, these compounds may be explored as potential therapeutic agents for PD patients. The present experiments, in part, may provide an explanation for the association between PD and the alpha-synuclein mutant.  (+info)

... is a derivative of carnosine, which has been methylated. Both anserine and carnosine chelate copper. Due to its ... Anserine reduced glial inflammatory activity (particularly of astrocyte). The study also found that anserine-treated mice had ... these found concentrations indicate the chelation of copper by Anserine and Carnosine. Look up anserine in Wiktionary, the free ... Anserine can be found in the skeletal muscle and brain of mammals and birds. The pKa of the imidazole ring of histidine, when ...
Pes anserine bursitis is a common inflammatory condition of the anserine bursa. Bojsen-Møller, Finn; Simonsen, Erik B.; Tranum- ... The anserine bursa (tibial intertendinous bursa) is a sub muscular bursa located deep to the pes anserinus on the anteromedial ...
... is an inflammatory condition of the medial (inner) knee at the anserine bursa, a sub muscular bursa, just ... Pes anserine bursitis may result from stress, overuse, obesity and trauma to this area. An occurrence of pes anserine bursitis ... These stretches have the potential to significantly reduce the tension over the pes anserine bursa.[citation needed] Anserine ... The likelihood of per anserine bursitis is increased in patients with osteoarthritis. Sometimes they report weakness or ...
... is a curious gooseflesh-like follicular hyperkeratosis that may result from persistent pressure ...
Pelc, Janusz (October 1991). "Polacy nie gęsi..." [Poles speak not Anserine...]. Tajemnice Atari (in Polish) (6/91): 3. OCLC ...
Stenesh JJ; Winnick T (1960). "Carnosine-anserine synthetase of muscle. 4. Partial purification of the enzyme and further ... carnosine-anserine synthetase', 'homocarnosine synthetase', and 'carnosine-homocarnosine synthetase'. The gene encoding this ...
McManus IR (April 1962). "Enzymatic synthesis of anserine in skeletal muscle by N-methylation of carnosine" (PDF). Journal of ... anserine Thus, the two substrates of this enzyme are S-adenosyl methionine and carnosine, whereas its two products are S- ... the formation of anserine is catalyzed by methyltransferase that is unrelated to the reptilian and avian enzyme and encoded by ... adenosylhomocysteine and anserine. This enzyme belongs to the family of transferases, specifically those transferring one- ...
It is a component of the peptides carnosine and anserine and also of pantothenic acid (vitamin B5), which itself is a component ... Mannion, AF; Jakeman, PM; Dunnett, M; Harris, RC; Willan, PLT (1992). "Carnosine and anserine concentrations in the quadriceps ...
Mannion, AF; Jakeman, PM; Dunnett, M; Harris, RC; Willan, PLT (1992). "Carnosine and anserine concentrations in the quadriceps ... Acetylcarnosine, a similar molecule used to treat lens cataracts Anserine, another dipeptide antioxidant (found in birds) ... anserine, and N -acetyl carnosine against permanent focal ischemia". Journal of Neuroscience Research. 86 (13): 2984-2991. doi: ... anserine, and N-acetyl carnosine against permanent focal ischemia". Journal of Neuroscience Research. 86 (13): 2984-91. doi: ...
... anserine or Pelagornithidae (same as Caspiodontornis?) Chenornis (Early Miocene) - anserine or Phalacrocoracidae Paranyroca ( ... anserine or tadornine Anatidae gen. et sp. indet. (Waite Late Miocene of Alcoota, Australia) - anatine, oxyurine? Anatidae gen ... was sometimes considered an anserine. It is now recognized as a primitive cormorant. The middle Eocene Eonessa was formerly ...
Serum carnosinase is a glycoprotein, and splits free carnosine and anserine in the blood. This form of the dipeptidase is not ... It is a dimer, and hydrolyzes both carnosine and anserine, preferring dipeptides that have a histidine monomer in the C- ...
Pes anserinus tendinitis/bursitis syndrome, or pes anserine bursitis, is a cause of chronic knee pain and weakness. It occurs ...
This distal attachment is the stronger of the two and makes up the floor of the pes anserine bursa. The proximal tibial ... The distal tibial attachment of the sMCL can be found under these identified tendons, making up the floor of the pes anserine ...
It has been argued that Rej here uses "gęsi" not as a noun ("geese") but as an adjective ("anserine"); thus, rather than saying ... "that Poles speak not Anserine [i.e., Latin] but a tongue of their own." Czesław Miłosz, The History of Polish Literature, ...
Carnosine (beta-alanyl-L-histidine) and Anserine (beta-alanyl-N-methyl histidine) are highly concentrated in muscle and brain ...
"Pigmented villonodular bursitis/diffuse giant cell tumor of the pes anserine bursa: a report of two cases and review of ...
... anserine)? pelagornithid (same as Caspiodontornis)? †Tiliornis senex Ameghino 1899 (Late? Oligocene of Argentina)- ...
... an amino acid produced by aspartate 1-decarboxylase and a precursor to coenzyme A and the peptides carnosine and anserine. γ- ...
... the following chemical reaction Hydrolysis of Xaa-His dipeptides This mammalian cytosolic enzyme also acts on anserine and ...
... involved in converting carnosine to anserine present in skeletal muscle. Another interactor is CDC5L, which is a positive ...
Achilles bursitis Retrocalcaneal bursitis Ischial bursitis, "weaver's bottom" Iliopsoas bursitis Anserine bursitis It is ...
Bursae are readily inflamed when irritated, as their walls are very thin.: p. 22 Along with the pes anserine bursa, the ...
Pain at the midpoint between the anterior part of the medial joint line and tibial tuberosity is suggestive of Pes anserine ... bursitis (inflammation of anserine bursa. Lateral joint line tenderness is associated with lateral compartment osteoarthritis, ...
One of the many conditions that can disrupt the use of the sartorius is pes anserine bursitis, an inflammatory condition of the ...
Their diets can consist of amphibians (mainly frogs and pond turtles), bird predation (mainly anserine species), small rodents ...
This enzyme catalyses the following chemical reaction Hydrolysis of anserine (beta-alanyl!Npi-methyl-L-histidine), carnosine, ...
... of the bill of anserine birds. In fact the papillae observed in the embryonic birds are the soft cutaneous extensions into the ...
AICAR AWRQNTRYSRIEAIKIQILSKLRL-amide Anserine beta-Hydroxybutyric acid GHRH analogues stimulate the release of growth hormone. ...
... plate Stippled nails Subungual hematoma Telogen effluvium Terry's nails Traction alopecia Traumatic alopecia Traumatic anserine ...
The describing authors concluded that Allgoviachen would have had a body size comparable to the extant anserine Anser indicus ( ...
Anserine is a derivative of carnosine, which has been methylated. Both anserine and carnosine chelate copper. Due to its ... Anserine reduced glial inflammatory activity (particularly of astrocyte). The study also found that anserine-treated mice had ... these found concentrations indicate the chelation of copper by Anserine and Carnosine. Look up anserine in Wiktionary, the free ... Anserine can be found in the skeletal muscle and brain of mammals and birds. The pKa of the imidazole ring of histidine, when ...
... also referred to as anserine or pes anserine bursitis) is an inflammatory condition of the medial knee. Especially common in ... Management of pes anserine bursitis. Pes anserine bursitis is primarily a self-limiting condition. [3] Patients generally are ... Diagnosis of pes anserine bursitis. The diagnosis of pes anserine bursitis usually is made on clinical grounds, and further ... Signs and symptoms of pes anserine bursitis. Typical findings in patients with pes anserine bursitis may include the following: ...
... also referred to as anserine or pes anserine bursitis) is an inflammatory condition of the medial knee. Especially common in ... encoded search term (Pes Anserine Bursitis) and Pes Anserine Bursitis What to Read Next on Medscape ... Pes Anserine Bursitis Workup. Updated: Jun 15, 2023 * Author: P Mark Glencross, MD, MPH, FACOEM, FAAPMR; Chief Editor: Milton J ... Pes anserine bursitis - an extra-articular manifestation of gout. Bull NYU Hosp Jt Dis. 2010. 68(1):46-50. [QxMD MEDLINE Link] ...
Anserine , C10H16N4O3 , CID 112072 - structure, chemical names, physical and chemical properties, classification, patents, ...
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Pes Anserine Bursitis or 'Goose Foot' inflammation.Pes Anserine refers to the confluence of three muscles in the ... Understanding conditions like Pes Anserine Bursitis can help us take better care of our bodies and maintain our overall health ... Regular exercise, maintaining a healthy weight, and strength training can help reduce the risk of developing Pes Anserine ... Pes Anserine'. The word "bursitis" refers to inflammation of a bursa, a small fluid-filled sac that serves as a ...
After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased ... After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased ... These results suggest that daily carnosine/anserine supplementation can impact cognitive function and that network connectivity ... These results suggest that daily carnosine/anserine supplementation can impact cognitive function and that network connectivity ...
Anserine (Beta-alanyl-N(Pi)-methyl-L-histidine) is a methylated derivative of carnosine (Beta-alanyl-L-histidine) and an ... The formation of anserine is catalyzed by carnosine N-methyltransferase (CARNMT1), which transfers a methyl group from S- ... UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase Piecuch, M, Kozlowski, P, de Heer, E, Chrobok, L, ... 2015). While CARNMT1 produces anserine in mammals, a similar reaction is catalysed by a different enzyme (carnosine N- ...
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Symptoms that may indicate you have pes anserine bursitis and proven home treatment options for getting rid of it quickly. ... Pes Anserine Bursitis is also known as Goosefoot Bursitis. The pes anserine bursa is found on the inside of the knee joint. ... Pes Anserine (Goosefoot) Bursitis Home Remedies. If you suspect you may have bursitis, the first thing to do is consult your ... If your pes anserine bursitis was caused due to the nature of your work, you really need to stop that type of work until the ...
Anserine was found to significantly reduce blood uric acid levels and improve liver and kidney damage, indicating that anserine ...
CO offers treatment for pes anserine bursitis also called as goosefoot bursitis. ... Treatment for Pes Anserine Bursitis. Some of the methods employed in the treatment of pes anserine bursitis include:. *Activity ... Pes anserine bursitis is the inflammation of the pes anserine bursa present between the tendons of the hamstring muscle and the ... Causes of Pes Anserine Bursitis. Pes anserine bursitis mainly results from overuse or constant stress and friction on the bursa ...
Bursitis of the knee and pes anserine bursitis are treated at Palm Beach Orthopaedic Institute in Palm Beach Gardens, Jupiter, ...
describing the anatomical structures related to Repetitive Strain of the Pes Anserine. This assignment for anatomy course so ...
Pes Anserine Bursitis , Dr. David Trofa, Orthopaedic Surgeon, Sports Medicine & Cartilage Restoration Specialist, New York, ... Treatment for Pes Anserine Bursitis. Some of the methods employed in the treatment of pes anserine bursitis include:. *Activity ... Pes anserine bursitis is the inflammation of the pes anserine bursa present between the tendons of the hamstring muscle and the ... Causes of Pes Anserine Bursitis. Pes anserine bursitis mainly results from overuse or constant stress and friction on the bursa ...
The anserine bursa is found about 2 inches below the knee along the inner side, and anserine bursitis causes pain in that area ... The pes anserine bursae in the inner side of the knee, about 2 inches below the joint ... Its sometimes called housemaids knee or carpet layers knee.) Another type is anserine bursitis. ...
Featured Article: Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and ...
Pes Anserine Bursitis bfloyd6969. Training & Nutrition. 5. 08-03-12 02:43 PM ...
Williams: That medial inferior to the joint line point tenderness is consistent with pes anserine bursitis. Theres a bursa ... Whether its a tendonitis or pes anserine bursitis doesnt matter; the treatment should help. ...
anserine of, like or pertaining to geese apatetic of an animals coloration or markings apian of, like or pertaining to bees ...
anserine1349704732and appears on 49 listswas added by Arvesse and appears on 49 lists ...
Pediatric Reference Intervals, Eighth Edition, is a must-have for clinical chemists, hematologists, pathologists, endocrinologists and pediatricians. This...
Article with the title Sarcoidal granulomatous reaction to microneedling with vitamin C serum published in the scientific journal JAAD Case Rep
Tibia: proximal, medial shaft at pes anserine tendon. Rectus femoris. Pelvis: anterior inferior iliac spine (AIIS). from/to. ...
pes anserine bursitis. *ilio-tibial band syndrome. *intra-articular: *ligamentous injuries - collateral and cruciate ...
Pes anserine bursitis. Lateral knee pain. ❑ Iliotibial band syndrome. ❑ Degenerative lateral meniscal tear ...
Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men ...
Severe pes anserine bursitis. Semimembranosus bursitis demonstrated in addition and there is a Bakers cyst as described.. ... He said it was pes anserine tendonitis. I mentioned having plica removed on that knee in 2017 so he added I also had plica on ...
Anserine. Anserine. ME544937. -. C01262. -. -. Arginine. Arginine. ME544905. -. C00062. -. -. Argininosuccinate. ...
Anserine. Synonyms:. [PubChem Synonyms]. Exact Mass:. 240.1222 (neutral) Calculate m/z: (Choose adduct). [M+H]+. [M+H-H2O]+. [M ...
  • Stress fractures of the proximal medial tibia may produce pain in the area of the pes anserine bursa. (medscape.com)
  • If the bursa, a fluid filled sac between the shin bone and the tendons, has become inflamed, the diagnosis will be pes anserine bursitis. (bauerfeind.com)
  • The pes anserinus (anserine) bursa, along with its associated tendons, is located along the proximomedial aspect of the tibia. (medscape.com)
  • A diagnostic or therapeutic lidocaine or lidocaine-corticosteroid injection into the area of the pes anserine bursa may help the clinician to determine the contribution of pes anserine bursitis to a patient's overall knee pathology, as well as possibly alleviate the patient's symptoms. (medscape.com)
  • Pes anserine bursa injection is used to treat the chronic bursitis that is seen in overuse sports, especially dancers or runner. (orthofixar.com)
  • After Pes Anserine Bursa Injection, avoid overuse activities until pain free. (orthofixar.com)
  • This article explores the causes and implications of inflammation of the pes anserine bursa and what treatment regimens are found to be successful for it. (prohealthclinic.co.uk)
  • Pes Anserine Bursitis, specifically, is the inflammation of the Pes Anserine Bursa. (prohealthclinic.co.uk)
  • The common factors that promote the onset of Pes Anserine Bursitis include direct trauma to the Bursa, obesity, overuse of the structures, tight hamstrings, and mechanical derangement. (prohealthclinic.co.uk)
  • This inflammation does not only end up promoting the Pes Anserine Bursa on its own but may also lead to other knee complications and structural deformities, which may eventually lead to the inflammation of these Bursa. (prohealthclinic.co.uk)
  • Pes anserine bursitis is an irritation of a bursa in your knee, located on the inner side of the knee just below the knee joint. (agilitydoctor.com)
  • [4] The tendon then curves over the pes anserine bursa, which is superficial to the medial collateral ligament, and inserts into the superior anteromedial surface of the tibia. (nih.gov)
  • Pes anserinus and anserine bursa: anatomical study. (legehandboka.no)
  • Pes Anserine bursa is a small lubricating sac located between the shinbone (tibia), and the tendons of three muscles called gracilis, sartorius, and semi-tendinosus.Any injury to Pes Anserine bursa can lead to inflammation and irritation , swelling, stiffness, hot to the touch, stinging sensations, and tenderness. (newhealthguide.org)
  • The Pes Anserine bursa is located between the shin bone and the 3 tendons of the hamstring muscles, on the inside of the knee. (brighamandwomens.org)
  • Runners can develop pain and inflammation in the pes anserine bursa, situated on the inner side of your knee below the joint. (middlesexhealth.org)
  • One case report documents distal tibial pain from entrapment of the saphenous nerve caused by pes anserine bursitis. (medscape.com)
  • Saphenous nerve entrapment caused by pes anserine bursitis mimicking stress fracture of the tibia. (qxmd.com)
  • Anserine is a derivative of carnosine, which has been methylated. (wikipedia.org)
  • Both anserine and carnosine chelate copper. (wikipedia.org)
  • Due to its methylation, anserine is more stable in serum and resistant to degradation than carnosine. (wikipedia.org)
  • A human study on 84 elderly subjects showed that subjects who took anserine and carnosine supplements for one year showed increased blood flow in the prefrontal cortex on MRI. (wikipedia.org)
  • A study demonstrated that the free N-terminal of histidine on anserine and carnosine protect against zinc-caused neurotoxicity and regulate the Arc pathway in which Arc protein is used to produce dendrite protein for connecting nerve cells. (wikipedia.org)
  • Both Anserine and Carnosine are chelating agents for copper and other transition metals. (wikipedia.org)
  • these found concentrations indicate the chelation of copper by Anserine and Carnosine. (wikipedia.org)
  • In a previously reported double-blind, randomized controlled trial (RCT), we demonstrated that daily supplementation with anserine (750 mg) and carnosine (250 mg) improves brain blood flow and memory function in elderly people. (nih.gov)
  • Here, we conducted a sub-analysis of MRI data and test scores from the same RCT to determine whether anserine/carnosine supplementation specifically benefits elderly people carrying the APOE e4 allele, which is a risk gene for accelerated brain aging and for the onset of Alzheimer's Disease. (nih.gov)
  • We collected data from 68 participants aged 65 years or older who received anserine/carnosine supplementation (ACS) or placebo for 12 months. (nih.gov)
  • Early research suggests that taking a single dose of a specific chicken breast extract (CBEX) containing carnosine and anserine by mouth does not improve cycling power in healthy active men. (medicinenet.com)
  • N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. (nih.gov)
  • Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. (nih.gov)
  • The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. (nih.gov)
  • 1 ) It is considered an important part of the knee for the reconstructive surgery of tendons or the steroid injection treatment of Anserine Bursitis. (prohealthclinic.co.uk)
  • The pes anserine tendons are used frequently in the form of autographs for surgeries involving knee ligamentous reconstruction. (prohealthclinic.co.uk)
  • Others may also report tenderness when the skin over the insertion of the Pes Anserine Tendons is pressed. (prohealthclinic.co.uk)
  • Inner knee pain running can be caused by pes anserine tendonitis, which is an inflammation or irritation of the tendons located near the muscles of gracilis, sartorius, and semitendinosus. (newhealthguide.org)
  • The deep bursae (trochanteric, subacromial, or anserine) lie between bone and overlying tendons. (msdmanuals.com)
  • Pes Anserine bursitis is known as the inflammation of the bursae which is located at the inside of the knee below the kneecap. (pereaclinic.com)
  • So-called snapping tendinitis of the semitendinosus tendon is usually thought of as distinct from pes anserine bursitis, but some authorities classify it as the same inflammatory disorder. (medscape.com)
  • Pay Attention to the Pes Anserine in Knee Osteoarthritis. (legehandboka.no)
  • Pes anserine bursitis, affecting the inner side of your knee below the joint, often occurs in obese women with osteoarthritis. (middlesexhealth.org)
  • Pes anserinus bursitis (also referred to as anserine or pes anserine bursitis) is an inflammatory condition of the medial knee. (medscape.com)
  • The pes anserine, or so-called goose's foot, is the combined tendon of insertion of the sartorius, gracilis and semitendinosis. (orthofixar.com)
  • Identify pes anserine tendon by flexing knee against resistance. (orthofixar.com)
  • Anserine can be found in the skeletal muscle and brain of mammals and birds. (wikipedia.org)
  • Bursitis in the knee is also called goosefoot bursitis or Pes Anserine bursitis. (brighamandwomens.org)
  • As individuals cross their legs, the three muscles, known as the semitendinosus, Gracilis, and Sartorius, work in connection with each other, which is why this motion most commonly triggers pain, as seen in Pes Anserine Bursitis. (prohealthclinic.co.uk)
  • This may also be referred to as the pes anserine pain syndrome, which is mainly characterized by medial knee pain. (prohealthclinic.co.uk)
  • Helfenstein M, Kuromoto J. Anserine syndrome. (legehandboka.no)
  • [ 1 , 2 ] Diagnosis of pes anserine bursitis should be considered when there is spontaneous pain inferomedial to the knee joint. (medscape.com)
  • The diagnosis of pes anserine bursitis usually is made on clinical grounds, and further workup is not necessarily indicated. (medscape.com)
  • Pes Anserine Bursitis Diagnosis is mainly based on clinical assessment. (prohealthclinic.co.uk)
  • Distal tibial pain, initially managed as a stress fracture, resolved when a pes anserine bursitis was treated. (qxmd.com)
  • Anserine (β-alanyl-3-methylhistidine) is a dipeptide containing β-alanine and 3-methylhistidine. (wikipedia.org)
  • Runners suffering from inner knee pain, or pain on the inner tibial plateau, are often diagnosed with pes anserine bursitis. (bauerfeind.com)
  • Pes Anserine is a term used to refer to the insertion of three muscles at the proximal end of the Tibia. (prohealthclinic.co.uk)
  • Effect of polydeoxyribonucleotide injection on pes anserine bursitis: A case report. (orthofixar.com)
  • Sarifakioglu B, Afsar SI, Yalbuzdag SA, Ustaömer K, Bayramoğlu M. Comparison of the efficacy of physical therapy and corticosteroid injection in the treatment of pes anserine tendino-bursitis. (legehandboka.no)
  • As mentioned earlier, obesity is a common risk factor for Pes Anserine Bursitis. (prohealthclinic.co.uk)
  • Therefore, since individuals with diabetes are at an increased risk for Pes Anserine Bursitis, obesity indirectly plays a causative role. (prohealthclinic.co.uk)
  • Anserine reduced glial inflammatory activity (particularly of astrocyte). (wikipedia.org)
  • The sports that increase the individual risk for Pes Anserine Bursitis include Running, Basketball, and racquet sports, as they may lead to overuse and acceleration of the inflammatory activity. (prohealthclinic.co.uk)
  • 4. Anti-hepatitis B virus activities of triterpenoid saponin compound from Potentilla anserine L. (nih.gov)
  • Pes anserine tendonitis may exist exclusively or in conjunction with bursitis. (medscape.com)
  • When it comes to pes anserine bursitis, you might wonder if it is a torn medial ligament or an injury to the meniscus. (bauerfeind.com)
  • Important: Only your physician will be able to confirm whether your knee pain really is pes anserine bursitis. (bauerfeind.com)
  • This is normal to question, as the pain of a torn medial ligament can be very similar to pes anserine bursitis. (bauerfeind.com)
  • Community-dwelling older adults can also present with complaints of knee pain in which pes anserine bursitis and other nonarticular conditions may play a role. (medscape.com)
  • Individuals with Pes Anserine Bursitis commonly complain of pain on the inside of the knee, also referred to as the medial aspect. (prohealthclinic.co.uk)
  • Worn-out running shoes or a suboptimal running technique, too, can lead to pes anserine bursitis. (bauerfeind.com)
  • It is important to note that anyone can be affected with pes anserine bursitis, including novice and seasoned runners who have cut corners with training safely. (bauerfeind.com)
  • An animal model study of Alzheimer's disease using mice found that treatment with anserine reduced memory loss. (wikipedia.org)
  • The study also found that anserine-treated mice had greater pericyte surface area. (wikipedia.org)
  • They drifted in that direction over the course of a a quarter-glass, with Sif watching carefully to see if they'd been made by foes either human or anserine. (insanejournal.com)