Annexin A2
A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.
Annexin A5
Annexin A6
Annexin A4
Annexin A7
Annexin A3
Annexins
Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.
S100 Proteins
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Phosphatidylserines
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Propidium
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Calcium-Binding Proteins
Cell Membrane
Protein Binding
Cells, Cultured
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Amino Acid Sequence
Receptors, Formyl Peptide
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.
Caspase 3
Blotting, Western
Organotechnetium Compounds
Cell Survival
Caspases
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Fluorescein-5-isothiocyanate
In Situ Nick-End Labeling
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
Fibrinolysin
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
Binding Sites
NFATC Transcription Factors
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.
Equidae
Calcineurin
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
Creutzfeldt-Jakob Syndrome
A rare transmissible encephalopathy most prevalent between the ages of 50 and 70 years. Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset. A familial form exhibiting autosomal dominant inheritance and a new variant CJD (potentially associated with ENCEPHALOPATHY, BOVINE SPONGIFORM) have been described. Pathological features include prominent cerebellar and cerebral cortical spongiform degeneration and the presence of PRIONS. (From N Engl J Med, 1998 Dec 31;339(27))
Membrane Lipids
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Antibodies
beta 2-Glycoprotein I
A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.
Factor VII
Atlases as Topic
Islets of Langerhans
Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.
Organic Chemicals
DNA Primers
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Sensitivity and Specificity
Sequence Analysis, DNA
HIV-1 Gag shares a signature motif with annexin (Anx7), which is required for virus replication. (1/67)
Genetic and biochemical analyses of the Gag protein of HIV-1 indicate a crucial role for this protein in several functions related to viral replication, including viral assembly. It has been suggested that Gag may fulfill some of the functions by recruiting host cellular protein(s). In our effort to identify structural and functional homologies between Gag and cellular cytoskeletal and secretory proteins involved in transport, we observed that HIV-1 Gag contains a unique PGQM motif in the capsid region. This motif was initially noted in the regulatory domain of synexin the membrane fusion protein of Xenopus laevis. To evaluate the functional significance of the highly conserved PGQM motif, we introduced alanine (A) in place of individual residues of the PGQM and deleted the motif altogether in a Gag expression plasmid and in an HIV-1 proviral DNA. The proviral DNA containing mutations in the PGQM motif showed altered expression, assembly, and release of viral particles in comparison to parental (NL4-3) DNA. When tested in multiple- and single-round replication assays, the mutant viruses exhibited distinct replication phenotypes; the viruses containing the A for the G and Q residues failed to replicate, whereas A in place of the P and M residues did not inhibit viral replication. Deletion of the tetrapeptide also resulted in the inhibition of replication. These results suggest that the PGQM motif may play an important role in the infection process of HIV-1 by facilitating protein-protein interactions between viral and/or viral and cellular proteins. (+info)Annexin VII and annexin XI are tyrosine phosphorylated in peroxovanadate-treated dogs and in platelet-derived growth factor-treated rat vascular smooth muscle cells. (2/67)
The intraperitoneal administration of peroxovanadate results in the rapid accumulation of many tyrosine-phosphorylated proteins in the liver and kidney of treated animals. The availability of large pools of tyrosine-phosphorylated proteins derived from normal tissues facilitates the purification and identification of previously unknown targets for cellular tyrosine kinases. Using this procedure, we have thus far identified four proteins in the liver and kidney of peroxovanadate-treated dogs. Two of these, annexin VII and annexin XI, were novel and had not been previously reported to be substrates of tyrosine kinases while the remaining two, ezrin and clathrin, have been reported to be tyrosine phosphorylated in some cell culture systems. In the present study, isolated proteins were identified both by sequence analysis and immunological methods. Annexin VII and annexin XI are present in cultured rat vascular smooth muscle cells and both were tyrosine phosphorylated in response to a physiological ligand, platelet-derived growth factor-BB (PDGF-BB). Furthermore, the extent of tyrosine phosphorylation in response to PDGF-BB was augmented by the co-addition of peroxovanadate to cell cultures. In vitro phosphorylation assays showed that PDGF receptor, calcium-dependent tyrosine kinase (CADTK/Pyk-2), Src kinase, and epidermal growth factor receptor all were able to phosphorylate purified annexin VII and XI on tyrosine residues. These findings confirm the usefulness of phosphatase inhibition by peroxovanadate as a tool for identifying previously unknown physiological targets for cellular protein tyrosine kinases. (+info)Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. (3/67)
The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic beta cells, we knocked out the anx7 gene in the mouse and tested the insulin-secretory properties of the beta cells. The nullizygous anx7 (-/-) phenotype is lethal at embryonic day 10 because of cerebral hemorrhage. However, the heterozygous anx7 (+/-) mouse, although expressing only low levels of ANX7 protein, is viable and fertile. The anx7 (+/-) phenotype is associated with a substantial defect in insulin secretion, although the insulin content of the islets, is 8- to 10-fold higher in the mutants than in the normal littermate control. We infer from electrophysiological studies that both glucose-stimulated secretion and voltage-dependent Ca(2+) channel functions are normal. However, electrooptical recordings indicate that the (+/-) mutation has caused a change in the ability of inositol 1,4,5-trisphosphate (IP(3))-generating agonists to release intracellular calcium. The principle molecular consequence of lower anx7 expression is a profound reduction in IP(3) receptor expression and function in pancreatic islets. The profound increase in islets, beta cell number, and size may be a means of compensating for less efficient insulin secretion by individual defective pancreatic beta cells. This is a direct demonstration of a connection between glucose-activated insulin secretion and Ca(2+) signaling through IP(3)-sensitive Ca(2+) stores. (+info)Annexins VII and XI are present in a human macrophage-like cell line. Differential translocation on FcR-mediated phagocytosis. (4/67)
We have studied the divalent cation-dependent association of proteins to subcellular fractions of human macrophage-like cells before and after FcR-mediated phagocytosis. Among these proteins we have identified annexins VII and XI for the first time in these cells, along with annexins I, III, and VI. Although all of these annexins are present in the cytosolic fraction, the extent of their association to membrane and phagosome fractions from resting and stimulated cells is variable. Annexin VII translocates from cytosolic to membrane fractions after phagocytic stimulation, along with annexin I, III, and VI. Annexins VII and XI are found associated with purified phagosomes along with I, III, and VI, and this association is greater after a 24-h chase period. Our results show differences in the intracellular distribution of different annexins in macrophage-like cells on phagocytosis. Annexins VII, VI, III, and I respond to particle ingestion by translocating to phagosomes and other cell membrane structures, whereas annexin XI translocates predominantly to phagosomes, suggesting dissimilarities in their function. (+info)The sorcin-annexin VII calcium-dependent interaction requires the sorcin N-terminal domain. (5/67)
Surface plasmon resonance experiments show that at neutral pH the stability of the complex between sorcin and annexin VII (synexin) increases dramatically between 3 and 6 microM calcium; at the latter cation concentration the K(D) value is 0.63 microM. In turn, the lack of complex formation between the sorcin Ca(2+) binding domain (33-198) and synexin maps the annexin binding site to the N-terminal region of the sorcin polypeptide chain. Annexin VII likewise employs the N-terminal domain, more specifically the first 31 amino acids, to interact with sorcin [Brownawell, A.M. and Creutz, C.E. (1997) J. Biol. Chem. 272, 22182-22190]. The interaction may involve similar structural motifs in the two proteins, namely GGYY and GYGG in sorcin and GYPP in synexin. (+info)The annexinopathies: a new category of diseases. (6/67)
The annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family - annexin VI - having a duplication consisting of eight domains. Thus far, ten annexins have been described in mammals. Although the biological functions of the annexins have not been definitively established, two human diseases involving annexin abnormalities ('annexinopathies') have been identified as of the time of writing. Overexpression of annexin II occurs in the leukocytes of a subset of patients having a hemorrhagic form of acute promyelocytic leukemia. Underexpression of annexin V occurs on placental trophoblasts in the antiphospholipid syndrome and in preeclampsia. Also, an animal model has been described in which annexin VII is underexpressed and is associated with disease, but the relevance of this animal model to human disease is not yet understood. Future research is likely to elucidate additional 'annexinopathies'. (+info)Activation of annexin 7 by protein kinase C in vitro and in vivo. (7/67)
Annexin 7, a Ca(2+)/GTP-activated membrane fusion protein, is preferentially phosphorylated in intact chromaffin cells, and the levels of annexin 7 phosphorylation increase quantitatively in proportion to the extent of catecholamine secretion. Consistently, various protein kinase C inhibitors proportionately reduce both secretion and phosphorylation of annexin 7 in these cells. In vitro, annexin 7 is quantitatively phosphorylated by protein kinase C to a mole ratio of 2.0, and phosphorylation is extraordinarily sensitive to variables such as pH, calcium, phospholipid, phorbol ester, and annexin 7 concentration. Phosphorylation of annexin 7 by protein kinase C significantly potentiates the ability of the protein to fuse phospholipid vesicles and lowers the half-maximal concentration of calcium needed for this fusion process. Furthermore, other protein kinases, including cAMP-dependent protein kinase, cGMP-dependent protein kinase, and protein-tyrosine kinase pp60(c-)(src), also label annexin 7 with high efficiency but do not have this effect on membrane fusion. In the case of pp60(c-)(src), we note that this kinase, if anything, modestly suppresses the membrane fusion activity of annexin 7. These results thus lead us to hypothesize that annexin 7 may be a positive mediator for protein kinase C action in the exocytotic membrane fusion reaction in chromaffin cells. (+info)ANX7, a candidate tumor suppressor gene for prostate cancer. (8/67)
The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. To test whether ANX7 might be a candidate TSG, we examined the ANX7-dependent suppression of human tumor cell growth, stage-specific ANX7 expression in 301 prostate specimens on a prostate tissue microarray, and loss of heterozygosity (LOH) of microsatellite markers at or near the ANX7 locus. Here we report that human tumor cell proliferation and colony formation are markedly reduced when the wild-type ANX7 gene is transfected into two prostate tumor cell lines, LNCaP and DU145. Consistently, analysis of ANX7 protein expression in human prostate tumor microarrays reveals a significantly higher rate of loss of ANX7 expression in metastatic and local recurrences of hormone refractory prostate cancer as compared with primary tumors (P = 0.0001). Using four microsatellite markers at or near the ANX7 locus, and laser capture microdissected tumor cells, 35% of the 20 primary prostate tumors show LOH. The microsatellite marker closest to the ANX7 locus showed the highest rate of LOH, including one homozygous deletion. We conclude that the ANX7 gene exhibits many biological and genetic properties expected of a TSG and may play a role in prostate cancer progression. (+info)
ANXA7 antibodies | Antibodypedia
Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. | JCB
Anti-Annexin VII antibody (ab97323) | Abcam
PRINTS Search
Ring theory
Maillon Triomphe Belt with Horsebit in Natural Calfskin - Tan - 45ANX3A78.04LU | CELINE
Trial search results | Cancer Research UK
Mutagenetix > Incidental...
ANXA13 Gene - GeneCards | ANX13 Protein | ANX13 Antibody
Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse
Ttc - Pregnancy: Trying to Conceive (TTC) - MedHelp
Annexin A3 | Profiles RNS
重组人Annexin A3蛋白(ab92929)|Abcam中国
Gentaur Molecular :Biotium \ ANNEXIN V CF633 CONJUGATE \ 29008
Gentaur Molecular :Biotium \ ANNEXIN V CF488 CONJUGATE \ 29005
RESEARCH OF THE FACTORS AFFECTING DEPRESSION, ANX?ETY AND STRESS LEVELS OF INDIVIDUALS IN THE COVID-19 PANDEMIC PROCESS |...
TumorPortal
Invitrogen™ eBioscience™ Annexin V, Recombinant Protein Unlabeled; 300μg Invitrogen™ eBioscience™ Annexin V, Recombinant Protein
Is there any link between low serotonin levels and eye pain/flashes of light? Dry eyes. Ever since Ive got off anx meds at...
Annexin A2抗体|Abcam中国|Anti-Annexin A2抗体(ab90643)
ADVENTRX Pharmaceuticals Announces Closing of Financing - Drugs.com MedNews
Trypsin and Annexin
Human ANXA6 ELISA Kit | biobool.com
PE/Cy7 Annexin V
Annexin V Apoptosis Assay - Phosphatidylserine Detection by Annexin V
Annexin V Apoptosis Assay - Phosphatidylserine Detection by Annexin V
Annexin V FITC Conjugate from human placenta
Annexin A11 Antibody 10479-2-AP | Proteintech
Annexin A1 (1-25) (dephosphorylated) (human) H-3196 | Bachem
Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model
Annexin A1 Antibody 6E4/3 | V3741 NSJ Bioreagents
AID 502910 - Induction of annexin 2-mediated cytoskeleton aggregate accumulation in human HepG2 cells at 4 uM after 2 hrs by...
Assisted Living in Wm Penn Anx E, Pennsylvania (PA) | SeniorsforLiving
October 7, 2015 - Autophagy UK Network
A Real-Time Annexin V Method for Monitoring Programmed Cell Death
Methylamine decreases trafficking and packaging of newly synthesized phosphatidylcholine in lamellar bodies in alveolar type II...
Annexin A2 (C-terminal region) - ECM Biosciences
Invitrogen™ eBioscience™ Annexin V Apoptosis Detection Kit PerCP-eFluor™ 710 200 tests Invitrogen™ eBioscience™ Annexin V...
Membrane fusion protein - Wikidata
Staff Expertise at the University of Otago, New Zealand
List of MeSH codes (D12.776.157)
... annexin a5 MeSH D12.776.157.125.050.110 - annexin a6 MeSH D12.776.157.125.050.120 - annexin a7 MeSH D12.776.157.125.412.249 - ... annexin a1 MeSH D12.776.157.125.050.060 - annexin a2 MeSH D12.776.157.125.050.070 - Annexin A3 MeSH D12.776.157.125.050.080 - ...
Annexin A7
... is a protein that in humans is encoded by the ANXA7 gene. Annexin VII is a member of the annexin family of calcium- ... "Entrez Gene: ANXA7 annexin A7". Satoh, Hirokazu; Nakano Yoshimi; Shibata Hideki; Maki Masatoshi (Nov 2002). "The penta-EF-hand ... "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent ... The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in ...
Human papillomavirus infection
The two major carcinogenic HPV clades, alphapapillomavirus-9 (A9) and alphapapillomavirus-7 (A7), contain HPV16 and HPV18, ... 2012). "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLOS ONE ... with clade A7 being associated with more aggressive pathways and an inferior prognosis. In 2012, about 528,000 new cases and ... and annexin A2 leading to entry of the virions into basal epithelial cells through clathrin-mediated endocytosis and/or ...
Annexin A7 - Wikipedia
Annexin A7 is a protein that in humans is encoded by the ANXA7 gene. Annexin VII is a member of the annexin family of calcium- ... "Entrez Gene: ANXA7 annexin A7". Satoh, Hirokazu; Nakano Yoshimi; Shibata Hideki; Maki Masatoshi (Nov 2002). "The penta-EF-hand ... "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent ... The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in ...
PREDICTED: annexin A7-like [Hydra vulgaris] - Protein - NCBI
Record removed. This record was removed as a result of standard genome annotation processing. See the genome build documentation at http://www.ncbi.nlm.nih.gov/genome/guide/build.shtml for further information, or contact [email protected] ...
RCSB PDB - Protein Feature View
- Annexin A7 - P20073 (ANXA7 HUMAN)
Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling. | Sigma-Aldrich
Annexin A7 (Anxa7) is a cytoskeletal protein interacting with Ca(2+) signaling which in turn is a crucial factor for cardiac ... Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling.. [Jakob Voelkl, Ioana Alesutan, ... These observations point to an important role of annexin A7 in the regulation of cardiac NFAT activity and hypertrophic ...
Propolis Reduces Phosphatidylcholine-Specific Phospholipase C Activity and Increases Annexin a7 Level in Oxidized-LDL...
H. Li, S. Huang, S. Wang et al., "Relationship between annexin A7 and integrin 4 in autophagy," International Journal of ... H. Li, S. Huang, S. Wang et al., "Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine- ... Propolis Reduces Phosphatidylcholine-Specific Phospholipase C Activity and Increases Annexin a7 Level in Oxidized-LDL- ...
Annexin A7 Recombinant Protein
... ANXA7 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 150mM NaCl, 1mM DTT ... Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin VII has molecular ... Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including ...
Targeting annexin A7 by a small molecule suppressed the activity of phosphatidylcholine-specific phospholipase C in vascular...
Recombinant Human Annexin A7, T7-tagged ANXA7-68H - Creative BioMart
Recombinant Human annexin A7 produced inE.coliis a non-glycosylated, polypeptide chain containing amino acids (1-466) and ... ANXA7 annexin A7 [ Homo sapiens ]. Synonyms:. ANXA7; annexin A7; SNX; ANX7; SYNEXIN; Annexin A7; Annexin-7; Annexin VII; ... Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin VII has molecular ... Recombinant Human Annexin A7, T7-tagged. Download Datasheet See All ANXA7 Products. Bring this labeled protein directly to your ...
Annexins: linking Ca 2+ signalling to membrane dynamics | Nature Reviews Molecular Cell Biology
A unique class of these proteins - annexins - can bind to certain membrane phospholipids in a Ca2+-dependent manner, providing ... By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment ... These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane ... now known as annexin A7). It also reports a hallmark activity for this annexin - Ca2+-dependent vesicle aggregation. ...
Product Overview anti-Annexin VII Antibodies
Selected quality suppliers for anti-Annexin VII antibodies. ... Order monoclonal and polyclonal Annexin VII antibodies for many ... Protein level used designations for anti-Annexin A7 (ANXA7) Antibodies annexin VII , annexin-7 , annexin A7 , synexin , annexin ... Mouse (Murine) Annexin A7 (ANXA7) interaction partners * Study demonstrates that annexin A7 protein has an important role in ... anti-Annexin A7 (ANXA7) Antibodies. Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding ...
Deletion of Immunoproteasome Subunits Imprints on the Transcriptome and Has a Broad Impact on Peptides Presented by Major...
KEGG BRITE: Exosome - Rattus norvegicus (rat)
KEGG BRITE: Exosome - Mus musculus (mouse)
Gene transcriptions/A1BG - Wikiversity
Anti-Annexin VII antibody (ab97323) | Abcam
Rabbit polyclonal Annexin VII antibody validated for WB, IHC and tested in Human. With 1 independent review. Immunogen ... Annexin A7 antibody. *Annexin VII antibody. *Annexin-7 antibody. *ANX7 antibody. *ANXA7 antibody ... All lanes : Anti-Annexin VII antibody (ab97323) at 1/2000 dilution. Lane 1 : 293T whole cell lysate. Lane 2 : A431 whole cell ... A pair of annexin repeats may form one binding site for calcium and phospholipid. ...
Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate | PNAS
Tissue expression of ANXA7 - Summary - The Human Protein Atlas
Annexin A7. Protein classi. Protein class the gene product belongs to according to selected gene lists. List of protein classes ... Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains ... Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal ... Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including ...
Gene Info
FAM168A Recombinant Protein Antigen (NBP1-81525PEP): Novus Biologicals
DNA polymerase delta p50 Antibody Pair (H00005425-AP21): Novus Biologicals
Search Results | jns
Browse ORF cDNA clones by species Homo sapiens, letter a, page 6
Anxa7 - PrimePCR Assay and Template | Life Science | Bio-Rad
Annexin A7 Assay Type: SYBR® Green Assay Design: exonic Application: Gene Expression Unique Assay ID: qRnoCED0002713 ... Annexin A7 Assay Type: Probe Assay Design: exonic Application: Gene Expression Unique Assay ID: qRnoCEP0024544 FAM HEX TEX 615 ... Annexin A7 Assay Type: EvaGreen Application: Gene Expression Unique Assay ID: dRnoEG5125653 Info: EG; Same primer pair as used ... Annexin A7 Assay Type: Probe Application: Gene Expression Unique Assay ID: dRnoCPE5147284 Info: FAM; Same primer pair and probe ...
Annexin elisa and antibody
Recombinant Protein and Annexin Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available. ... Annexin A7. Annexin A7 ELISA Kit. Annexin A7 Recombinant. Annexin A7 Antibody ... Also known as Annexin A7 (Annexin VII) (Annexin-7).. Calcium/phospholipid-binding protein which promotes membrane fusion and is ... Annexin A1 isoform p35. Annexin A1 isoform p35 ELISA Kit. Annexin A1 isoform p35 Recombinant. Annexin A1 isoform p35 Antibody ...
KEGG BRITE: Exosome - Oryctolagus cuniculus (rabbit)
AAGCCAT MIR135A MIR135B
ANXA7 - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad
annexin A7 Aliases:. ANX7, SNX, SYNEXIN RefSeq:. NC_000010.10 NT_030059.13 Ensembl:. ENSG00000138279 ... Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains ... Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique highly hydrophobic N-terminal ... Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including ...
ANXA7 purified MaxPab mouse polyclonal antibody (B01P) - (H00000310-B01P) - Products - Abnova
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains ... Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal ... Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including ... annexin A7. *Omim ID:. *186360. *Gene Ontology:. *Hyperlink. *Gene Summary:. * ...
nature.com search
Journal of Veterinary Medical Science
Therefore, the expression of all annexins was examined in LβT2 gonadotrope cells. ANXA4, A5, A6, A7 and A11 were detected in L ... Annexin A1 is a novel target gene of gonadotropin-releasing hormone in LβT2 gonadotrope cells ... We previously demonstrated that the expression of annexin A5 (ANXA5) is stimulated by GnRH in gonadotropes and has a ...
Proteins17
- Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. (wikipedia.org)
- Annexins are a multigene family of Ca 2+ -regulated proteins that are characterized by a unique Ca 2+ - and membrane-binding module - the annexin core domain. (nature.com)
- A unique class of these proteins - annexins - can bind to certain membrane phospholipids in a Ca 2+ -dependent manner, providing a link between Ca 2+ signalling and membrane functions. (nature.com)
- By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment platforms for proteins with which they interact. (nature.com)
- Liemann, S. & Lewit-Bentley, A. Annexins: a novel family of calcium- and membrane-binding proteins in search of a function. (nature.com)
- Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. (antibodies-online.com)
- Additionally we are shipping Annexin VII Proteins (16) and Annexin VII Kits (13) and many more products for this protein. (antibodies-online.com)
- Annexin A7 modulates BAG4 and BAG4-binding proteins in mitochondrial apoptosis. (semanticscholar.org)
- Annexins (ANXs) are widely expressed and structurally related proteins which play multiple biological roles in animals, plants, and fungi. (frontiersin.org)
- Although ANXs have been localized to the cytosol and the cell membrane and the molecular basis of the four annexin repeats is well established, the in vivo roles of these proteins are still far from clear, particularly with regard to the filamentous fungi. (frontiersin.org)
- Annexin is a known calcium (Ca 2+ )-phospholipid binding protein, and the annexin family includes more than 160 unique proteins present in more than 65 different species, ranging from fungi and protists to plants and higher vertebrates ( Gerke and Moss, 2002 ). (frontiersin.org)
- Annexins are traditionally thought of as calcium-dependent phospholipid-binding proteins, but recent work suggests a more complex set of functions. (beds.ac.uk)
- More than a thousand proteins of the annexin superfamily have been identified in major eukaryotic phyla, but annexins are absent from yeasts and prokaryotes. (beds.ac.uk)
- Animal and fungal annexins also have non-homologous amino-terminal domains of varying length and sequence, which are responsible for the distinct localizations and specialized functions of the proteins through post-translational modification and binding to other proteins. (beds.ac.uk)
- Annexins comprise a class of calcium-dependent, phospholipidbinding proteins that are broadly expressed in eukaryotic cells. (pkcinhibitor.com)
- Annexin A8-like 2 (ANXA8L2) belongs to the annexin family of calcium-dependent phospholipid binding proteins. (neuromics.com)
- F-actin is accumulated promptly at the site of mem- (https://www.weblio.jp/content/%E4%B8%80% 2+ brane disruption and annexins, phospholipid-interacting proteins with Ca -binding activity, E8%88%AC%E8%B2%A1%E5%9B%A3%E6% are also recruited to the injured site and contribute to membrane repair [3]. (deepdyve.com)
Protein12
- Annexin A7 is a protein that in humans is encoded by the ANXA7 gene. (wikipedia.org)
- Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. (wikipedia.org)
- Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. (wikipedia.org)
- Annexin A7 (Anxa7) is a cytoskeletal protein interacting with Ca(2+) signaling which in turn is a crucial factor for cardiac remodeling following cardiac injury. (sigmaaldrich.com)
- It harbours binding sites for cytoplasmic protein ligands that can be targeted to membranes through the annexin-core-mediated phospholipid interaction. (nature.com)
- Study demonstrates that annexin A7 protein has an important role in gastric cancer. (antibodies-online.com)
- Also known as Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Lipocortin-like 33 kDa protein) (Phospholipase A2 inhibitory protein) (p35). (mybiosource.com)
- Description This Annexin V calcium dependent phospholipid binding protein will be downstream of BCL2 pathway and at caspase apoptotic level. (gentaur.com)
- A gene on chromosome 9q21.13 that encodes annexin 1, a calcium/phospholipid-binding protein that promotes membrane fusion and is involved in exocytosis. (thefreedictionary.com)
- Annexin is a naturally occurring human protein, produced by recombinant techniques, which is the key component of the Apomate(TM) kit. (thefreedictionary.com)
- We prepared Annexin A7 recombinant protein using prokaryotic expression, adsorbed the Annexin A7 antibody with it after identified by mass spectrometry, and detected the expression of Annexin A7 by Western-blot and immunohistochemistry. (bvsalud.org)
- A protein of the annexin family that catalyzes the conversion of 1-D-inositol 1,2-cyclic phosphate and water to 1-D-myo-inositol 1-phosphate. (umassmed.edu)
Member of the annexin family1
- ANXA10: a member of the annexin family. (mybiosource.com)
Apoptosis3
- We recently found a small chemical molecule (6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine, ABO) that could inhibit oxidized low-density lipoprotein (oxLDL)-induced apoptosis and promote autophagy in VECs, and further identified ABO as an inhibitor of annexin A7 (ANXA7) GTPase. (sigmaaldrich.com)
- Annexin A7 caused an anti-apoptosis phenotype in mouse hepatocarcinoma cells. (semanticscholar.org)
- Down-regulated expression of Annexin A7 induces apoptosis in mouse hepatocarcinoma cell line by the intrinsic mitochondrial pathway. (ptgcn.com)
Localization of annexin2
- These results were confirmed by the co-localization of Annexin A7 and Stra8, a known determinant of differentiated spermatogonial stem cells (SSCs). (bvsalud.org)
- Function, expression and localization of annexin A7 in platelets and red blood cells: insights derived from an annexin A7 mutant mouse. (saladgaffe.ml)
Repeats4
- A pair of annexin repeats may form one binding site for calcium and phospholipid. (rcsb.org)
- Contains 4 annexin repeats. (abcam.com)
- The unique annexin core domain is made up of four similar repeats approximately 70 amino acids long, each of which usually contains a characteristic 'type 2' motif for binding calcium ions. (beds.ac.uk)
- Plant annexins (the D family) make up a monophyletic cluster whose members generally lack amino-terminal domains and functional calcium-binding sites in their second and third repeats [ 7 ] (see below). (beds.ac.uk)
Tumor4
- In this case, Bredel and his co-authors discovered that a specific spliced form of the membrane-binding tumor suppressor annexin A7, or ANXA7, leads to the decreased breakdown of a receptor, EGFR, that contributes to the growth of tumor cells. (uab.edu)
- OBJECTIVES: To assess whether coselection of EGFR gains on 7p12 and monosomy 10 in glioblastomas promotes tumorigenic epidermal growth factor (EGF) signaling through loss of the annexin A7 (ANXA7) gene on 10q21.1-q21.2 and whether ANXA7 acts as a tumor suppressor gene by regulating EGFR in glioblastomas. (luriechildrens.org)
- Ferrarese and colleagues hypothesized that alternative splicing of annexin A7 ( ANXA7 ), a membrane-bound tumor suppressor that undergoes tissue-specific exon skipping in the brain, contributes to glioblastoma progression. (aacrjournals.org)
- Tc-99m-hynic annexin is an experimental radiopharmaceutical in phase II studies for imaging cell death in vivo to provide non-invasive molecular characterization of tumors and early evaluation of tumor response to anti-cancer treatment. (thefreedictionary.com)
Satoh2
- Satoh, Nakano, Shibata, Maki: The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner. (antibodies-online.com)
- These include ALIX ( Q8WUM4 ) ( Vito,1999 ), TSG101 ( Q99816 ) ( Okumura,2009 ), Annexin A7 ( P20073 ) and A11 ( P50995 ) ( Satoh,2002 ), PLSCR3 ( Q9NRY6 ) and Sec31A ( O94979 ) ( Shibata,2008 ). (eu.org)
Extracellular roles1
- Figure 5: Annexins have specialized extracellular roles. (nature.com)
Cytosolic2
- Cytosolic Ca2+ was estimated from Fluo-3 fluorescence, cell volume from forward scatter, cell membrane scrambling from annexin V binding and cation channel activity with whole-cell patch-clamp in human erythrocytes. (deepdyve.com)
- At 200 μM spermine blunted the increase of intracellular Ca2+, cell shrinkage and annexin V binding following 48 h exposure of cells at +37°C. In contrast, short exposure (10-30 min) of cells to 2 mM spermine was accompanied by increased cytosolic Ca2+ and annexin binding. (deepdyve.com)
Cell membrane1
- Annexins interact with various cell-membrane components that are involved in the structural organization of the cell, intracellular signaling by enzyme modulation and ion fluxes, growth control, and they can act as atypical calcium channels. (beds.ac.uk)
Regulates1
- Annexin 1 regulates phospholipase A2 activity and thus may have anti-inflammatory activity. (thefreedictionary.com)
Intracellular1
- Interfering with intracellular annexin function, by overexpressing mutants or by using RNA-interference-mediated downregulation, has different effects depending on the annexin being targeted. (nature.com)
Lysate1
- Antigen standard for annexin A7 (ANXA7), transcript variant 2 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
Interaction1
- Each annexin contains a second, highly varible region - the N-terminal interaction domain. (nature.com)
Expression2
- High annexin A7 expression is associated with poor differentiation in gastric cancer patients, and it may be a predictor for lymphatic metastasis. (antibodies-online.com)
- To study the expression of Annexin A7 in the mouse testis, especially in different types of spermatogonia. (bvsalud.org)
Actin1
- Figure 3: The regulation of membrane-actin interactions by annexin A2. (nature.com)
Amino acids1
- Recombinant Human annexin A7 produced in E. coli is a non-glycosylated, polypeptide chain containing amino acids (1-466) and having a total molecular mass of 53.6 kda. (creativebiomart.net)
Tumorigenesis1
- it is likely that nuclear annexin A1 is involved in DNA replication, especially DNA damage induced gene mutation, since DNA damage induced mutagenesis plays an important role in tumorigenesis. (intechopen.com)
Mammals1
- Of the twelve Annexins expressed in mammals, Annexins A1, A2, A4, A5, A6 and A7 are expressed inside cells of the chondrogenic and osteoblastic lineage [five? (pkcinhibitor.com)
Cardiac3
- Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling. (sigmaaldrich.com)
- These observations point to an important role of annexin A7 in the regulation of cardiac NFAT activity and hypertrophic response following cardiac stress conditions. (sigmaaldrich.com)
- Recombinant human annexin is the core targeting component of Theseus Imaging Corporation's Apomate(TM) imaging agent now under development for the noninvasive assessment of early response to anti-cancer treatment and for evaluation of myocardial damage in acute myocardial infarction and cardiac transplant rejection. (thefreedictionary.com)
Membranes2
- This core domain enables Ca 2+ -bound annexins to peripherally dock onto membranes that contain negatively charged phospholipids. (nature.com)
- Figure 2: Annexin assemblies on membranes. (nature.com)
Family2
- Belongs to the annexin family. (abcam.com)
- Annexin family members are regulators of such varied processes such as ion flux, endocytosis and exocytosis, and cellular adhesion. (neuromics.com)
Organization2
- Membrane-bound annexins can form lateral self-assemblies that affect the mobility and organization of membrane lipids. (nature.com)
- Figure 4: Annexins in membrane organization and trafficking. (nature.com)
Human2
- Recombinant Human Annexin-VII at a concentration of 0.1mg containing 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3 and 10mM DTT. (creativebiomart.net)
- Crystal structure of human annexin I at 2.5 Å resolution. (nature.com)
Domain1
- Analysis of site-specific conservation in the core domain suggests a role for certain buried residues in the calcium-channel activity of vertebrate annexins and in the structural stability of their core domains. (beds.ac.uk)
Mouse1
- Extracellular annexin functions that have been substantiated by mouse knockout models are anti-inflammatory and fibrinolytic activities. (nature.com)
Interacts1
- Dysferlin interacts B3%95%E4%BA%BA%E8%97%A4%E4%BA% 2+ 95%E7%AF%80%E9%83%8E%E8%A8%98% with negatively charged phospholipids in a Ca -binding manner and its genetic defects result E5%BF%B5%E5%A4%A7%E9%98%AA%E5%9F in limb girdle muscular dystrophy type 2B [4]. (deepdyve.com)
Molecular2
- Swairjo, M. A. & Seaton, B. A. Annexin structure and membrane interactions: a molecular perspective. (nature.com)
- The annexin genes have duplicated extensively and independently in several eukaryotic lineages, as seen from their molecular phylogeny, their gene structures and their chromosomal positions. (beds.ac.uk)