Annexin A2: A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.Annexin A1: Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.Annexin A6: Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.Annexin A4: Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.Annexin A7: An annexin family member that plays a role in MEMBRANE FUSION and signaling via VOLTAGE-DEPENDENT CALCIUM CHANNELS.Annexin A3: A protein of the annexin family that catalyzes the conversion of 1-D-inositol 1,2-cyclic phosphate and water to 1-D-myo-inositol 1-phosphate.Annexins: Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.S100 Proteins: A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.Phosphatidylserines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Calcium-Binding Proteins: Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Cell Line, Tumor: A cell line derived from cultured tumor cells.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cell-Derived Microparticles: Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.Receptors, Formyl Peptide: A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Caspase 3: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Organotechnetium Compounds: Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Fibrinolysin: A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.

Characterization of the Ca2+-dependent binding of annexin IV to surfactant protein A. (1/59)

We have shown previously that surfactant protein A (SP-A) binds to annexin IV in a Ca2+-dependent manner [Sohma, Matsushima, Watanabe, Hattori, Kuroki and Akino (1995) Biochem. J. 312, 175-181]. Annexin IV is a member of the annexin family having four consensus repeats of about 70 amino acids and a unique N-terminal tail. In the present study, the functional site of both annexin IV and SP-A for the Ca2+-dependent binding was investigated using mutant proteins. SP-A bound in a Ca2+-dependent manner to an annexin-IV truncation mutant consisting of the N-terminal domain and the first three domains (T(N-1-2-3)). SP-A also bound to T3-4, but this interaction was not Ca2+-dependent. SP-A bound weakly to the other truncation mutants (T(N-1-2), T(2-3) and T(2-3-4)). Each consensus repeat of annexin IV possesses a conserved acidic amino acid residue (Glu70, Asp142, Glu226 and Asp301) that putatively ligates Ca2+. Using annexin-IV DE mutants in which one, two or three residues out of the four Asp/Glu were altered to Ala by site-directed mutagenesis [Nelson and Creutz (1995) Biochemistry 34, 3121-3132], it was revealed that Ca2+ binding in the third domain is more important than in the other Ca2+-binding sites. SP-A is a member of the animal lectin group homologous with mannose-binding protein A. The substitution of Arg197 of rat SP-A with Asp or Asn eliminated binding to annexin IV, whereas the substitution of Glu195 with Gln was silent. These results suggest that the Ca2+ binding to domain 3 of annexin IV is required for the Ca2+-dependent binding by SP-A and that Arg197 of SP-A is important in this binding.  (+info)

Detection of annexins I and IV in bronchoalveolar lavage fluids from calves inoculated with bovine herpes virus-1. (2/59)

Annexins are phospholipid-binding proteins and are abundant in the lung. Annexins I and IV, but not II and VI, have been detected in bronchoalveolar lavage (BAL) fluids from calves inoculated with Pasteurella haemolytica, the pathogen for calf pneumonia. In this study, BAL fluids from calves with experimental pneumonia induced by inoculation to right lung lobes of bovine herpes virus-1 (BHV-1), the major viral pathogen for pneumonia, were examined for detection of annexins I and IV. Of 6 calves inoculated with BHV-1, annexins I and IV were coincidentally detected in BAL fluids from right lung lobes of 4 calves, but not in BAL fluids from left lung lobes of 6 inoculated calves or those from left and right lung lobes of 3 control calves. Annexin II and VI were not found in any BAL fluids examined. These results, together with previous findings on calves inoculated with Pasteurella haemolytica, suggest that the release of annexins I and IV onto the alveolar surface is an essential event occurring in response to pulmonary infections of BHIV-1 and Pasteurella haemolytica.  (+info)

Immunolocalization of annexins IV, V and VI in the failing and non-failing human heart. (3/59)

The failing human heart is characterized by changes in the expression and function of proteins involved in intracellular Ca2+ cycling, resulting in altered Ca2+ transients and impaired contractile properties of cardiac muscle. The role of the cardiac annexins in this process remains unclear. Annexins may play a role in the regulation of Ca2+ pumps and exchangers on the sarcolemma, and have been shown to be altered in some cardiac disease states. OBJECTIVE: The goal of this study was to compare the immunolocalization and expression of annexins IV, V and VI in failing and non-failing human hearts. METHODS: We used immunostaining to identify the subcellular location of annexins IV, V and VI proteins within the myocardial cell, and Western blot analysis to quantify the proteins in the same hearts. RESULTS: Annexin IV showed a cytoplasmic distribution in both failing and non-failing human heart cells. Annexin V was localized at the z-line, around lipofuscin granules, and in the cytosol in the non-failing heart cells. Annexin VI was localized at the sarcolemma and intercalated disc. Protein levels of annexins IV and V were up-regulated in failing human hearts, while the expression of annexin VI was unchanged. CONCLUSIONS: Alterations in the intracellular localization of annexins, along with up-regulation of annexins IV and V in the failing human heart cells, suggests differential regulation of these Ca2+ regulatory proteins during heart failure.  (+info)

Modulation of paclitaxel resistance by annexin IV in human cancer cell lines. (4/59)

A recurring problem with cancer therapies is the development of drug resistance. While investigating the protein profile of cells resistant to a novel antimitotic compound (A204197), we discovered an increase in annexin IV expression. When we examined the annexin IV protein expression level in a paclitaxel-resistant cell line (H460/T800), we found that annexin IV was also overexpressed. Interestingly a closely related protein, annexin II, was not overexpressed in H460/T800 cells. Immunostaining with either annexin II or IV antibody revealed that annexin IV was primarily located in the nucleus of paclitaxel-resistant H460/T800 cells. Short-term treatment of H460 cells with 10 nM paclitaxel for up to 4 days resulted in induction of annexin IV, but not annexin II expression. In addition, there was an increase in annexin IV staining in the nucleus starting at day 1. Furthermore, cells pretreated with 10 nM paclitaxel for 4 days resulted in cells becoming approximately fivefold more resistant to paclitaxel. Transfection of annexin IV cDNA into 293T cells revealed that there was a threefold increase in paclitaxel resistance. Thus our results indicate that annexin IV plays a role in paclitaxel resistance in this cell line and it is among one of the earliest proteins that is induced in cells in response to cytotoxic stress such as antimitotic drug treatment.  (+info)

Differential lipid specificities of the repeated domains of annexin IV. (5/59)

The roles of the four domains of annexin IV in binding to phospholipids and glycolipids were assessed by analyzing the binding of a group of mutant annexins IV in which one or more of the four domains was inactivated by replacing a critical amino residue(s) (Asp or Glu) with the neutral residue Ala. The data reveal that individual annexin domains may have characteristic affinities for different lipids. In particular, inactivation of the fourth domain inhibits the binding to phosphatidylserine (PS) and phosphatidylinositol (PI) but not to phosphatidylglycerol (PG), suggesting that this domain specifically can accommodate the larger head groups of PS and PI whereas the other three domains may form more restricted binding pockets. In order to block binding to PG, domain 1, or both domains 2 and 3 must be inactivated in addition to domain 4, suggesting that all four domains may be able to accommodate the headgroup of PG to some extent. Binding to acidic glycolipids (sulfatides) was also sensitive to inactivation of domain 4. However, in the case of sulfatides the nature of the binding reaction is fundamentally different compared with the binding to phospholipids since the interaction with sulfatides was highly sensitive to an increase in ionic strength. The binding to sulfatides may depend therefore on charge-charge interactions whereas the binding to phospholipid may involve a more specific interaction between the lipid headgroup and the protein surface, and/or interaction of the protein with the hydrophobic portion of a lipid bilayer.  (+info)

UDP hydrolase activity associated with the porcine liver annexin fraction. (6/59)

In the crude fraction of porcine liver annexins, we identified annexin IV (AnxIV), AnxII and AnxVI of MW (molecular weight) of 32, 36 and 68 kDa, respectively, an albumin of MW of 61.5 kDa and an UDP hydrolase (UDPase) of MW of 62 kDa, related to the human UDPase from Golgi membranes. The latter enzyme exhibits its highest specificity towards UDP and GDP but not ADP and CDP, and it is stimulated by Mg(2+) and Ca(2+). AnxVI itself, although it binds purine nucleotides, does not exhibit hydrolytic activity towards nucleotides. Taken together, these results suggest that AnxVI may interact in vivo with a nucleotide-utilizing enzyme, UDPase. This is in line with observations made by other investigators that various annexins are able to interact with nucleotide-utilizing proteins, such as protein kinases, GTPases, cytoskeletal proteins and p120(GAP). Such interactions could be of particular importance in modulating the biological activities of these proteins in vivo.  (+info)

Annexin IV (Xanx-4) has a functional role in the formation of pronephric tubules. (7/59)

Vertebrate kidney organogenesis is characterised by the successive formation of the pronephros, the mesonephros and the metanephros. The pronephros is the first to form and is the functional embryonic kidney of lower vertebrates; although it is vestigial in higher vertebrates, it is a necessary precursor for the other kidney types. The Xenopus pronephros is a simple paired organ; each nephron consists of a single large glomus, one set of tubules and a single duct. The simple organisation of the pronephros and the amenability of Xenopus laevis embryos to manipulation make the Xenopus pronephros an attractive system in which to study organogenesis. It has been shown that pronephric tubules can be induced to form in presumptive ectodermal tissue by treatment with RA and activin. We have used this system in a subtractive hybridisation screen that resulted in the cloning of Xenopus laevis annexin IV (Xanx-4). Xanx-4 transcripts are specifically located to the developing pronephric tubules, and the protein to the luminal surface of these tubules. Temporal expression shows zygotic transcription is upregulated at the time of pronephric tubule specification and persists throughout pronephric development. The temporal and spatial expression pattern of Xanx-4 suggests it may have a role in pronephric tubule development. Overexpression of Xanx-4 yields no apparent phenotype, but Xanx-4 depletion, using morpholinos, produces a shortened, enlarged tubule phenotype. The phenotype observed can be rescued by co-injection of Xanx-4 mRNA. Although the function of annexins is not yet clear, studies have suggested a role for annexins in a number of cellular processes. Annexin IV has been shown to have an inhibitory role in the regulation of epithelial calcium-activated chloride ion conductance. The enlarged pronephric tubule phenotype observed may be attributed to incorrect modulation of exocytosis, membrane plasticity or ion channels and/or water homeostasis. In this study, we demonstrate an in vivo role for annexin IV in the development of the pronephric tubules in Xenopus laevis.  (+info)

Cloning and characterization of ZAP36, an annexin-like, zymogen granule membrane associated protein, in exocrine pancreas. (8/59)

ZAP36, a zymogen granule membrane associated protein with 36 kDa, was cloned from both canine and rat pancreas. ZAP36 is found to be a novel member of annexin IV, and showed an apical localization in exocrine pancreas and an ubiquitous expression in epithelial tissues. ZAP36 may be involved in exocytosis in apical regions of polarized cells.  (+info)

*Annexin A5

... (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect ... Annexin A5 showed upregulation in papillary thyroid carcinoma. Annexin A5 is used as a non-quantitative probe to detect cells ... Annexin A5 forms a shield around negatively charged phospholipid molecules. The formation of an annexin A5 shield blocks the ... The annexin A5 affinity assay typically uses a conjugate of annexin V and a fluorescent or enzymatic label, biotin or other ...

*Annexin A3

... is a protein that in humans is encoded by the ANXA3 gene. It is abnormally expressed in fetuses of both IVF and ICSI ... "Entrez Gene: ANXA3 annexin A3". Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human ... 2005). "Annexin A3 is a potential angiogenic mediator". Biochem. Biophys. Res. Commun. 337 (4): 1283-7. doi:10.1016/j.bbrc. ... "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V". Biochemistry. 35 (6): 1740 ...

*Annexin A4

... is a protein that in humans is encoded by the ANXA4 gene. Annexin IV (ANX4) belongs to the annexin family of calcium ... "Entrez Gene: ANXA4 annexin A4". Human ANXA4 genome location and ANXA4 gene details page in the UCSC Genome Browser. Römisch J, ... Dreier R, Schmid KW, Gerke V, Riehemann K (Aug 1998). "Differential expression of annexins I, II and IV in human tissues: an ... Han EK, Tahir SK, Cherian SP, Collins N, Ng SC (Jul 2000). "Modulation of paclitaxel resistance by annexin IV in human cancer ...

*Annexin A5 affinity assay

This clustering of annexin A5 on the membrane greatly increases the intensity of annexin A5 when labeled with a fluorescent or ... Labeling of annexin A5 with fluorescent or radioactive molecules makes it possible to detect binding of labeled annexin A5 to ... Internalization amplifies additionally the intensity of the annexin A5 stained cell. Annexin A5 has been used to successively ... annexin A5 assembles into a trimeric cluster. This trimer consists of three annexin A5 molecules that are bound to each other ...

*Antiphospholipid syndrome

Annexin A5 forms a shield around negatively charged phospholipid molecules, thus reducing their availability for coagulation. ... Thus, anti-annexin A5 antibodies increase phospholipid-dependent coagulation steps. The Lupus anticoagulant antibodies are ...

*Integrin, beta 5

... has been shown to interact with PTK2, Annexin A5 and PAK4. Elevated levels of ITGB5 have been found in ... "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. United States. ...

*Kinase insert domain receptor

Annexin A5 and SHC1. Cluster of differentiation VEGF receptors Holmes K, Roberts OL, Thomas AM, Cross MJ (October 2007). " ...

*Annexin

However some annexins (Annexin A1, Annexin A2, and Annexin A5) have also been found outside the cellular environment, for ... Annexin, type I InterPro: IPR002388 Annexin, type II InterPro: IPR002389 Annexin, type III InterPro: IPR002390 Annexin, type IV ... In addition to annexin A-II, annexin A-XI has also been shown to organize cell membrane properties. Annexin A-XI is believed to ... The 310 amino acid annexin core has four annexin repeats, each composed of 5 alpha-helices. The exception is annexin A-VI that ...

*Annexin Pharmaceuticals

The concept for the therapy is based on the anti-inflammatory properties of Annexin A5, a body own protective protein that acts ... Annexin Pharmaceuticals is a Swedish privately held biotech company developing new therapeutic approaches for inflammatory ... http://www.solidinfo.se/foretag/annexin-pharmaceuticals-ab/personer. ... "Annexin: Attenuating vascular inflammation" (PDF). BioCentury: A18. Retrieved 1 February 2015. ...

*Flow cytometry

Annexin A5 affinity assay, a test for cells undergoing apoptosis, often uses flow cytometry Cell cycle analysis Coulter counter ...

*List of MeSH codes (D08)

... annexin A3 MeSH D08.811.277.352.640.125 --- 3',5'-cyclic-GMP phosphodiesterase MeSH D08.811.277.352.640.150 --- 3',5'-cyclic- ... cytochromes a3 MeSH D08.244.187.249 --- cytochromes b MeSH D08.244.187.500 --- cytochromes b5 MeSH D08.244.187.600 --- ...

*List of MeSH codes (D12.776.157)

Annexin A3 MeSH D12.776.157.125.050.080 -- annexin a4 MeSH D12.776.157.125.050.100 -- annexin a5 MeSH D12.776.157.125.050.110 ... annexin a6 MeSH D12.776.157.125.050.120 -- annexin a7 MeSH D12.776.157.125.412.249 -- calmodulin MeSH D12.776.157.125.412.311 ... annexin a1 MeSH D12.776.157.125.050.060 -- annexin a2 MeSH D12.776.157.125.050.070 -- ...

*A3

... regulatory sequence, a sequence for the insulin gene Adenosine A3 receptor, a human gene Annexin A3, a human gene ATC code ... a band known as A3 in the U.S. to avoid confusion with the country group Alabama A-3, a Yamaha musical instrument product A3 ... a club football tournament also known as the East Asian Champions Cup Arrows A3, a 1980 racing car A3, a climbing Grade A-3 ... a British Isles plants community Gibberellin A3, a plant hormone HLA-A3, a Human MHC Serotype HLA-A Subfamily A3, a rhodopsin- ...

*A5

... and variants may refer to: A5 regulatory sequence in biochemistry Annexin A5, a human cellular protein ATC code A05 Bile and ... see section Military Chery A5, a 2006 Chinese car Audi A5, a 2007 luxury coupé Arrows A5, a 1982 British racing car A5 road, in ... the Apple mobile microprocessor ARM Cortex-A5, ARM applications processor A5/1, A5/2 and A5/3, ciphers used in cellular phones ... A-5, an export version of Nanchang Q-5, a Chinese-built jet fighter bomber Curtiss Falcon or A-5 Falcon, an attack aircraft ...

*S100A10

Annexin II, which is attracted to negatively charged phospholipids, binds to p11 at the Ca2+ binding site. In addition, Annexin ... "Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer ... Kwon M, MacLeod TJ, Zhang Y, Waisman DM (Jan 2005). "S100A10, annexin A2, and annexin a2 heterotetramer as candidate ... The p11 and annexin II complex is regulated by the phosphorylation of SerII on the annexin II molecule by protein kinase C (PKC ...

*Formyl peptide receptor 3

Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN (May 1997). "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 ... Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U (Jun 2004). "An annexin 1 N-terminal peptide activates leukocytes ... "The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is ... is not affected by lipoxin A4". Scandinavian Journal of Immunology. 56 (5): 470-6. doi:10.1046/j.1365-3083.2002.01149.x. PMID ...

*Proliferating cell nuclear antigen

Annexin A2, CAF-1, CDC25C, CHTF18, Cyclin D1, Cyclin O, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1C, DNMT1 ... E3 ubiquitin ligases • E2 SUMO-conjugating enzyme • Helicases, ATPases • Mismatch repair enzymes • Base excision repair enzymes ...

*Human papillomavirus infection

The HPV genome is composed of six early (E1, E2, E4, E5, E6, and E7) open-reading frames (ORF), two late (L1 and L2) ORFs, and ... and annexin A2 leading to entry of the virions into basal epithelial cells through clathrin-mediated endocytosis and/or ... "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLoS One. 7 (8): ...

*Formyl peptide receptor 2

... lipoxin A4 (LXA4). Because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. ... Ac2-26 and Ac9-25 of Annexin A1 (ANXA1 or lipocortin 1), which at high concentrations fully stimulate neutrophil functions but ... "Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 ... lipoxin A4 (LXA4), and thereafter for a related arachidonic acid metabolite, the Epi-lipoxin, aspirin-triggered lipoxin A4 (i.e ...

*Housekeeping gene

018229 ANXA6 Annexin 6 ANXA7 Annexin 7 AP1B1 Coated vessicles CLTA Clathrin A (vessicles) CLTB Clathrin B (vessicles) CLTC MTX2 ... 021178 E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression ... 003334 Homo sapiens ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature UBA2 NM_005499 UBA3 NM_003968 UBA5 NM_024818 ...

*Specialized pro-resolving mediators

These products are now termed lipoxin A4 and B4, respectively. While initially found to have in vitro activity suggesting that ... annexin A1 (an inhibitor of formation of pro-inflammatory metabolites of polyunsaturated fatty acids), and the gaseous ...

*Ubiquitin C

He KL, Deora AB, Xiong H, Ling Q, Weksler BB, Niesvizky R, Hajjar KA (July 2008). "Endothelial cell annexin A2 regulates ... "Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy". Proceedings of the ... "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Molecular Cell ... "Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated ...

*Formyl peptide receptor 1

Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN (May 1997). "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 ... Annexin A1 (also termed ANXA1 and lipocortin 1) and its N-terminal peptides (Ac2-26 and Ac9-25). At low concentrations, these ... FMLP and lipoxin A4. Isolated mouse Olfactory bulb neurons also respond to a range of other fpr agonists. These results suggest ... and functional characterization of a murine lipoxin A4 receptor homologue gene". Journal of Immunology. 169 (6): 3363-9. doi: ...

*Estrogen

The three major naturally occurring forms of estrogen in women are estrone (E1), estradiol (E2), and estriol (E3). Another type ... Nadkarni S, Cooper D, Brancaleone V, Bena S, Perretti M (November 2011). "Activation of the annexin A1 pathway underlies the ... The three major naturally occurring estrogens in women are estrone (E1), estradiol (E2), and estriol (E3). Estradiol is the ... A4), androstenediol (A5), 3α-androstanediol, and 3β-androstanediol. Some estrogen metabolites, such as the catechol estrogens 2 ...
The consolidation of unique players started back in 1996. The line up back then went back and forth with bass players, (clean & growl) singers and guitarists. After the Baroquean Menuets For Oesophagus -99, future was looking auspicious. Reviews were even better than expected, this EP had biggest national on-air time also and interesting gigs were offered in Finland as abroad. Stab in the back was to come ...
DEEBO1556d ago i played games that use sop system like mgo.ghost recon was one of them.i dont care if they dont agree with me,i was just sharing my experience with mgo.i wish it had a better online setup.batman origins is going to use some of mgo gameplay too.when the two teams were fighting and snake had to collect three dogtags. ...
Affiliation:大阪医科大学,医学部,講師, Research Field:Ophthalmology,Rehabilitation science/Welfare engineering, Keywords:緑内障,濾過手術,濾過胞,視神経挫滅モデル,ハイドロゲル,NAD,サーチュイン,徐放,視神経乳頭循環,眼圧, # of Research Projects:6, # of Research Products:19, Ongoing Project:Effect of a multikinase inhibitor on glaucoma surgery model
Hideo Kojimas taken to Twitter this morning to tease the Vita version of the Metal Gear Solid HD Collection. He posted two pics that highlight…
Huang, W., Wu, S., Gu, X., Li, Y., Okazawa, A., Kojima, N., Hayami, S., Baker, M. L., Bencok, P., Noguchi, M., Miyazaki, Y., Nakano, M., Nakanishi, T., Kanegawa, S., Inagaki, Y., Kawae, T., Zhuang, G. L., Shiota, Y., Yoshizawa, K., Wu, D. および1人, Sato, O., 12 1 2019, : : Nature communications. 10, 1, 5510.. 研究成果: ジャーナルへの寄稿 › 記事 ...
retrospektivna studija. Studija je obuhvatila ukupno 130 pacijenata sa AIMU kod kojih je primenjena CTP. Eksperimentalnu grupu je sačinjavalo 100 pacijenata kojima je aplikovana rtPA, a kontrolnu grupu 30 pacijenata, koji nisu primili rtPA. Svim ispitanicima su načinjeni: standardni CT pregled glave i CT perfuzija odmah nakon prijema i kontrolni standardni CT pregled endokranijuma 24 h nakon prijema u bolnicu. Pregledi su obavljeni sa 16-slajsnom MSCT aparatu, pri čemu je pokrivenost CTP iznosila 2 cm. „Mismatch" postoji ukoliko je perfuziona lezija na CBF mapi veća od perfuzionog deficita na CBV mapi (srţ infarkta). REZULTATI: Rezultati studije su pokazali da pacijenti oboleli od AIMU sa mismatchom manjim od 20% nisu imali koristi od primenjene rtPA, a pacijenti sa 20% i više mismatch-om su imali ili umeren ili značajan neurološki oporavak. Optimalni mismatch, kojim se postiže visoka uspešnost nakon rtPA je iznosio ˃ 101% penumbre. Pacijenti sa površinom perfuzionog deficita na ...
Naša glavna zadaća je razvoj kreativnih i inovativnih potencijala studenata kroz niz kolegija i projekata, u suradnji s industrijom, kojima je fokus na razvoju proizvoda i usluga, metodičkom konstruiranju te novim računalnim tehnologijama i alatima za podršku konstruiranju i razvoju.
J:204470 Inagawa M, Nakajima K, Makino T, Ogawa S, Kojima M, Ito S, Ikenishi A, Hayashi T, Schwartz RJ, Nakamura K, Obayashi T, Tachibana M, Shinkai Y, Maeda K, Miyagawa-Tomita S, Takeuchi T, Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Mech Dev. 2013 Nov-Dec;130(11-12):519-31 ...
Nobuhiro Terao; Hideki Koizumi; Kentaro Kojima; Tetsuya Yamagishi; Kenji Nagata; Koji Kitazawa; Yuji Yamamoto; Kengo Yoshii; Asako Hiraga; Munetoyo Toda; Shigeru Kinoshita; Chie Sotozono; Junji ...
Po tovani posetioci, ako elite da posetite neki od prilo enih linkova, u inite to klikom na logo sli icu (mini logo banner). Samo tada, va klik e biti registrovan i done e odgovaraju e poene izabranom sajtu. Zahvaljuju i va im klikovima, va i omiljeni sajtovi se mogu na i na TOP 5 listi (koja se dinami ki odre uje). TOP 5 listu prikazujemo na svim stranicama na eg sajta. Pored toga, sajtovi koji se nalaze na TOP 5 listi, prikazuju se i na svim sajtovima na kojima se nalazi postavljena na a markica (R)MONITOR-a. eleli smo da webmasterima sajtova obezbedimo i standardne linkove (bez redirekcije). Klik na neki od tih linkova (nalaze se u drugoj koloni) - sistem ne registruje i samim tim, takav klik ne uti e na poziciju sajta u okviru TOP 5 liste. ...
Annexins are a structurally related family of Ca2+ binding proteins of undertermined biological function. Annexin I (also called lipocortin 1) is a substrate for the EGF-stimulated tyrosine kinase and is postulated to be involved in mitogenic signal transduction. To investigate further the involvement of lipocortin 1 in cell proliferation, we measured lipocortin 1 levels in normal diploid human foreskin fibroblasts (HFF) to determine whether its expression changed as a function of growth status. For comparison, the expression of annexin V (also called endonexin II) was measured in HFF cells. Endonexin II is a protein with similar Ca2+ and phospholipid binding properties as lipocortin 1, but it is not a substrate for tyrosine kinases. Quiescent HFF cell cultures were induced to proliferate by either subculture to lower cell density, EGF stimulation, or serum stimulation. In all three protocols, proliferating HFF cells contained three- to fourfold higher levels of lipocortin 1 and three- to ...
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells ...
服部良一,児嶋長次郎,リジン残基13Cメチル化NMR法による相互作用解析と構造変化の検出,生物物理 56, 288-289 (2016). DOI: 10.2142/biophys.56.288 田中好幸,DNA分子を利用した水銀除染法及び機能性核酸構造解析法の開発研究,The ANNALS of Intelligent Cosmos Academic Foundation 14, 9-12 (2010). Yoshiyuki Tanaka and Akira Ono, Structural Studies on MercuryII-mediated T-T Base-pair with NMR Spectroscopy (Chapter 16), In Nick Hadjiliadis and Einar Sletten Eds., "Metal Complexes - DNA Interactions", John Wiley & Sons, West Sussex, UK (2009). DOI: 10.1002/9781444312089 Ikumi kawahara, Kaichiro Haruta, Chojiro Kojima, and Yoshiyuki Tanaka, NMR studies of HAC1 mRNA, Nucleic Acids Symposium Series 53, 269-270 (2009). Hisaaki Tateoka, Ikumi Kawahara, Satomi Hasegawa, Kaichiro Haruta, Yoshinori Kondo, Chojiro Kojima, and Yoshiyuki Tanaka, Preparations of hammerhead ribozymes for investigations of their cleavable sequences, Nucleic Acids ...
Blanker, M. H. (2013), Re: Kojima Y, et al. Tamsulosin reduces nighttime urine production in benign prostatic hyperplasia patients with nocturnal polyuria: A prospective open-label long-term study using frequency-volume chart. Neurourol Urodyn 2012;31:80-85. Neurourol. Urodyn., 32: 104. doi: 10.1002/nau.22260 ...
Life-History Effects:, Organs:, Pathology:, Serology:, Strains: A(CAL-A) (A/J), BALB/C, CBA/H-T6T6, C3H/HE, C3HEB, C57BL/6, 129, 129/RE, Unknown:. ...
As futile as most internet petitions may be, the power of an army of united voices is clearly very much still as real as it ever was. Following the announcement that he was abdicating the MGS throne after Snake Eater, Hideo Kojima started to feel the force of a legion of outraged fans. Demanding the return of Kojima to MGS4, the hate mail and even death threats started to pour in and it wasnt too long before the gaming legend was back on board, now co-directing Guns Of The Patriots with his would-be successor Shuyo Murata. So whether it was Kojimas intention to work on the project all along or whether the bullying zealots dragged him back against his wishes, the gangs all here now and theyll be looking to send Snake off with one hell of a bang. ...
iframe src="https://biblio.ugent.be/publication?q=author%3D%22Kojima%2C+Shoko*%22+or+(type+exact+bookEditor+and+editor%3D%22Kojima%2C+Shoko*%22)&embed=1&hide_pagination=1&hide_info=1&hide_options=1&hide_cluster=1" ...
Yasutaka Kojimas Coming back compiles a series of photographs of cityscapes in Tokyo since 2008. Kojimas beautiful selection of photographs, which shift effortlessly between monochrome and colour, and past and present, observe cities existing in a time during which our identity and subjectively has been somewhat lost in the urban environment, evoking a sense of evanescence. This beautiful publication arrives courtesy of the amazing Superlabo (Tokyo).. Coming Back - 33 ...
Kojima Mikiko , Kamada-Nobusada Tomoe , Komatsu Hirokazu , TAKEI Kentaro , KUROHA Takeshi , MIZUTANI Masaharu , ASHIKARI Motoyuki , UEGUCHI TANAKA Miyako , MATSUOKA Makoto , SUZUKI Koji , SAKAKIBARA Hitoshi Plant and cell physiology 50(7), 1201-1214, 2009-07-01 参考文献50件 被引用文献9件 ...
I also cant believe you actually made this podcast and cant believe i listened to the whole thing. I like hellopro egg discussion, I think their training is definitely beginning to pay off. I think they may be grooming Karin to be a solo artist or in a new group because if theyre not they are really dropping the ball. If youre going to be doing just random podcasts like this I would like to suggest one about Kojima Harunas ears…thank you. P.S. I predict that Mogi Minami will be Trons new Oshimen once Gaki leaves.. ...
by Noguchi, Emiko and Akiyama, Masato and Yagami, Akiko and Hirota, Tomomitsu and Okada, Yukinori and Kato, Zenichiro and Kishikawa, Reiko and Fukutomi, Yuma and Hide, Michihiro and Morita, Eishin and Aihara, Michiko and Hiragun, Makiko and Chinuki, Yuko and Okabe, Takahiro and Ito, Akiko and Adachi, Atsuko and Fukunaga, Atsushi and Kubota, Yumiko and Aoki, Toshiyuki and Aoki, Youko and Nishioka, Kazue and Adachi, Tetsuya and Kanazawa, Nobuo and Miyazawa, Hitoshi and Sakai, Hiroyuki and Kozuka, Takehito and Kitamura, Hideo and Hashizume, Hideo and Kanegane, Chiharu and Masuda, Koji and Sugiyama, Kumiya and Tokuda, Reiko and Furuta, Junichi and Higashimoto, Ikkou and Kato, Atsuko and Seishima, Mariko and Tajiri, Akihiko and Tomura, Atsuko and Taniguchi, Hiroko and Kojima, Hiroto and Tanaka, Hidenori and Sakai, Aiko and Morii, Wataru and Nakamura, Masashi and Kamatani, Yoichiro and Takahashi, Atsushi and Kubo, Michiaki and Tamari, Mayumi and Saito, Hirohisa and Matsunaga, Kayoko ...
Mediteranska Pjaca bogatija za novu šoping destinaciju. Na atraktivnoj lokaciji Narodnog trga 4 pronađite odeću svetskih modnih kuća koja je namenjena urbanoj, modno osvešćenoj populaciji. Svaki brand je priča za sebe koja se idealno uklapa u viziju Fashion&Friends-a. Replay, HilfigerDenim, Guess, Liu Jo, Liu Jo Uomo, Calvin Klein, Gaudi, Munich, Superdry, Voile Blanche, Colors of California, UGG, Premiata i MOU, samo su neki od brandova kojima nećete moći odoleti.. ...
Kojima had created small snips of Konstantins animation of the 7 of 10 Plate Movements. Here is the full 7 of 10 Animation by Konstantin. This blog is th…
SATOH Ayano , TAKAYAMA Eiji , KOJIMA Kyoko , OGAWA Haruko , YAMORI Takao , SATO Shigeo , KAWAGUCHI Tokuichi , TSURUO Takashi , KATSURA Yoshimoto , KINA Tatsuo , MATSUMOTO Isamu The journal of biochemistry 119(2), 346-353, 1996-02-01 医中誌Web 参考文献46件 被引用文献3件 ...
Takefumi Yoshida, Shinya Takaishi, Hiroaki Iguchi, Hiroshi Okamoto, Hisaaki Tanaka, Shin-ichi Kuroda, Yuka Hosomi, Shoji Yoshida, Hidemi Shigekawa, Tatsuhiro Kojima, Hiroyoshi Ohtsu, Masaki Kawano, Brian K. Breedlove, Laurent Guerin, and Masahiro Yamashita ...
We have examined the timing of specification of the pronephric tubules and duct in Xenopus laevis by explanting the presumptive pronephric rudiments into blastula ectodermal wraps. We have established I-he time point of specification using the monoclonal antibody markers 3G8 and 4A6 which recognize antigens in pronephric tubule and duct, respectively. We show that, by experimental analysis in explants, kidney tubules are specified by stage 12.5 in the pronephric anlagen whereas pronephric duct is specified later between stages 13 and 14. Furthermore we show that signals involved in tubulogenesis of the pronephric tubules are normally received between stage 12.5 and 13. These experiments unambiguously pinpoint the timing of pronephros specification analyzed by explant experimentation to a developmental stage prior to that demonstrated for urodele amphibia, and provide an essential biological backdrop to a search for the molecular nature of pronephric inducers. (C) 1998 Elsevier Science Ireland ...
Annexin A1 / ANXA1, 0.1 ml. Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane.
Annexin A6 (AnxA6) is a Ca2+-dependent membrane-binding protein involved in vesicular traffic. The likely participation of AnxA6 in the response of lymphocytes to Ca2+ signals has not been investigated yet. The present study focuses on intracellular relocation of AnxA6 in human Jurkat T lymphoblasts upon stimulation followed by transient increase of intracellular [Ca2+] and exocytosis of interleukin-2 (IL-2). Stimulation of the cells under different experimental conditions (by lowering pH and/or by rising extracellular [Ca2+] in the presence of ionomycin) induced time-dependent transients of intracellular [Ca2+] and concomitant changes in AnxA6 intracellular localization and in IL-2 secretion, with only minor effects on cell viability and apoptosis. In resting conditions (in the presence of EGTA or with no ionophore) AnxA6 was localized uniformly in the cytosol, whereas it translocated to vesicular structures beneath the plasma membrane within 5 min following stimulation of Jurkat T cells and ...
The pHi (intracellular pH) is an important physiological parameter which is altered during hypoxia and ischaemia, pathological conditions accompanied by a dramatic decrease in pHi. Sensors of pHi include ion transport systems which control intracellular Ca2+ gradients and link changes in pHi to functions as diverse as proliferation and apoptosis. The annexins are a protein family characterized by Ca2+-dependent interactions with cellular membranes. Additionally, in vitro evidence points to the existence of pH-dependent, Ca2+-independent membrane association of several annexins. We show that hypoxia promotes the interaction of the recombinant annexin A2-S100A10 (p11) and annexin A6 with the plasma membrane. We have investigated in vivo the influence of the pHi on the membrane association of human annexins A1, A2, A4, A5 and A6 tagged with fluorescent proteins, and characterized this interaction for endogenous annexins present in smooth muscle and HEK (human embryonic kidney)-293 cells ...
Motor adaptation is an important factor in the recovery of function following motor deficits associated with neural damage due to stroke, injury or aging. Such...
HK: Not many! [Laughs] I have a very yound, very inexperienced team. Many would think that this would be a disadvantage, but the opposite is true. My team have no expectations of the boundaries of what is or is not possible. I look at what they do and suggest improvements or additions. A more experienced team might say, "No, thats not possible- this is already as good as it can be", but my team will try different things and make them work! For example, the smoke effect when Snake has a cigarette. Such an effect is very demanding on the processors power, leading to poor performances from other features. People said it couldnt be done but we insisted. "Yes, we must have smoke! Its essential!", and now weve included it ...
After having released three stunning full-length albums and a split-EP between the years 1995 - 1999, Ulmes existence seemed to cease with a stroke of a fist, leaving their followers in a state of disbelief, anger and phantom limb pain, right after the release party for their third offering Green growing soul… in the gala of love. What fascinated their fans, who stemmed from Noise-Rock and partially from the Metal-scene was the juggernaut of their ever hypnotic, rolling groove - the spirit of the seventies combined with the sheer heaviness of the nineties ...
Bolouki, N., Sakai, K., Huang, T. Y., Isayama, S., Liu, Y. L., Peng, C. W., Chen, C. H., Khasanah, N., Chu, H. H., Moritaka, T., Tomita, K., Sato, Y., Uchino, K., Morita, T., Matsukiyo, S., Hara, Y., Shimogawara, H., Sakawa, Y., Sakata, S., Kojima, S. および6人, Fujioka, S., Shoji, Y., Tomiya, S., Yamazaki, R., Koenig, M. & Kuramitsu, Y., 7 2019, : : High Energy Density Physics. 32, p. 82-88 7 p.. 研究成果: ジャーナルへの寄稿 › 記事 ...
Ima puno videa o Access Barsu koje možete istražiti! Evo nekoliko sa kojima predlažemo da započnete, bez određenog redoslijeda. Što vam govori i golica vašu znatiželju? Možete također nastaviti na Youtube kanalu Access Consciousnessa. Ili saznati o Accessovom prijenosu uživo za još više mogućnosti. ...
Noriaki Tabata, Eiichiro Yamamoto, Seiji Hokimoto, Takayoshi Yamashita, Daisuke Sueta, Seiji Takashio, Yuichiro Arima, Yasuhiro Izumiya, Sunao Kojima, Koichi Kaikita, Kunihiko Matsui, Kazuteru Fujimoto, Kenji Sakamoto, Hideki Shimomura, Ryusuke Tsunoda, Toyoki Hirose, Natsuki Nakamura, Naritsugu Sakaino, Shinichi Nakamura, Nobuyasu Yamamoto, Toshiyuki Matsumura, Ichiro Kajiwara, Shunichi Koide, Tomohiro Sakamoto, Koichi Nakao, Shuichi Oshima, Kenichi Tsujita, Kumamoto Intervention Conference Study (KICS) Investigators ...
Principal Investigator:KOJIMA Syouzo, Project Period (FY):1997 - 2000, Research Category:Grant-in-Aid for Scientific Research on Priority Areas (A)
Štetni učinci pesticida na okoliš i neciljne organizme dobro su poznati. Kako bi se smanjio štetan utjecaj pesticida pojavljivale su se različite metode kojima je cilj smanjiti njihovu uporabu. Jedan od načina smanjenja pesticida je primjena nanočestica kao pesticida ili primjena istih kao nosača pesticida. Cilj ovog rada je bilo utvrditi pojedinačne i kombinirane učinke cinkovog oksida (ZnO) u nano i ne nano obliku te propikonazola (PCZ) na reprodukcijski uspjeh te biokemijske markere (acetilkolinesteraza (AChE), katalaza (CAT), glutation S-transferaza (GST) i reaktivne supstance tiobarbiturne kiseline (TBARS)) enhitreida (Enchytraeus albidus). Izračunata je manja EC50 vrijednost za ne nano čestice nego za nanočestice cinkovog oksida (ZnO). Rezultati eksperimenta pokazuju kako PCZ uzrokuje lipidnu peroksidaciju kod kombiniranog izlaganja. Kombinirano izlaganje nije utjecalo na povećanje oksidativnog stresa u usporedbi s pojedinačnim izlaganjem ...
Half of the points you made are core mechanics explained in the first 2 hours of gameplay and the other half is par for the course in a Kojima game. Hows...
Developed by Kojima Productions and PlatinumGames, METAL GEAR RISING: REVENGEANCE takes the renowned METAL GEAR franchise into exciting new territory with an all-new action experience. The game seamlessly melds pure action and epic story-telling that surrounds Raiden - a child soldier transformed into a half-human, half-cyborg ninja who...
Winter is a painful season for Satoko Kojima (not her real name), a Tokyo office worker who says she cannot tolerate cold temperatures. In the morning when
Masami Kojima; Hiroshi Sasaki; Kazuyuki Sasaki; Nailia Hasanova; Yukihisa Suzuki; Masao Taki; Kensuke Sasaki; Kanako Wake; Soichi Watanabe; Millimeter wave study ...
Charlotte M. Niemeyer, Mignon L. Loh, Annamaria Cseh, Todd Cooper, Christopher C. Dvorak, Rebecca Chan, Blanca Xicoy, Ulrich Germing, Seiji Kojima,Atsushi Manabe, Michael Dworzak, Barbara De Moerloose, Jan Starý, Owen P. Smith, Riccardo Masetti, Albert Catala, Eva Bergstraesser, Marek Ussowicz, Oskana Fabri, André Baruchel, Hélène Cavé, Michel Zwaan, Franco Locatelli, Henrik Hasle, Marry M. van den Heuvel-Eibrink, Christian Flotho, Ayami Yoshimi ...
There are many achievements beyond educational activities and research programs for the Geriatric Medicine Division. Some achievements include a CIHR-Eli Lilly Chair in Fracture, Falls and Osteoporosis Prevention, a Chair for St. Peters Centre for Studies in Aging, recruitment of new faculty and Clerkship awards. Over 240 learners, undergraduate and postgraduate, who rotate through the Geriatric Medicine Division participate in educational activities. Family practice residents spend one month in Geriatric Medicine in their final year. The division hosted the Tri-City Research Day for participants from the Universities of Toronto, Western Ontario and Waterloo. Faculty is involved in research teams, pilot studies in Geriatric issues and working on developing knowledge translation tools.
Masayuki Kojima is Vice President at Tokyo Electron Ltd. See Masayuki Kojimas compensation, career history, education, & memberships.
Taru wrestled one match against The Great Muta as The Great Ruta in November 2005. Taru challenged Satoshi Kojima for the Triple Crown on January 8, 2006. However, Kojima successfully defended his title. in July 2007, however, Kojima shocked the All-Japan roster when he turned on them and joined the Voodoo Murders, where he was quickly made the groups co-leader alongside Taru. Soon after joining, Kojima and Taru won the World Tag Team Championship. Along with Big Daddy Voodoo, he also won the All Asia Tag Team Championship.. On June 1, 2011, Taru was suspended indefinitely by AJPW after an alleged attack on stablemate Nobukazu Hirai leaving Hirai hospitalised with an acute hematoma. All Japan later also suspended Tarus stablemates Masayuki Kono, Mazada and Minoru for not attempting to stop Tarus assault on Hirai and immediately disbanded the Voodoo Murders, while the promotions president Keiji Mutoh took the blame for the incident and resigned from his position on June 7.[7] On June 30, ...
A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors / H Fukamachi; Seon-Kyu Kim; J Koh; H S Lee; Y Sasaki; K Yamashita; T Nishikawaji; S Shimada; Y Akiyama; S J Byeon; Dong Hyuck Bae; K Okuno; M Nakagawa; T Tanioka; M Inokuchi; H Kawachi; K Tsuchiya; K Kojima; T Tokino; Y Eishi; Yong Sung Kim; W H Kim; Y Yuasa; S Tanaka , 2019 ...
Period2 3 '-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation. Yoo, Seung-Hee; Kojima, Shihoko; Shimomura, Kazuhiro; Koike, Nobuya; Buhr, Ethan D.; Furukawa, Tadashi; Ko, Caroline H.; Gloston, Gabrielle; Ayoub, Christopher; Nohara, Kazunari; Reyes, Bryan A.; Tsuchiya, Yoshiki; Yoo, Ook-Joonresearcher; Yagita, Kazuhiro; Lee, Choogon; Chen, Zheng; Yamazaki, Shin; Green, Carla B.; Takahashi, Joseph S.NATL ACAD SCIENCESPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.114, no.42, pp.E8855 - E8864, 2017-10 ...
Nadam se da si dobro proucio kontraindikacije salbutamola- Ventolina, a ako imas argumente, klinicka istrazivanja, studije ili nesto slicno, po kojima je korist salbutamola u smislu bodybuildinga veca od njegove stetnosti izazvane bilo kakvom upotrebom duzom od 14 hyperventilation, molim te da to objavis. We have just conducted a learned debate now whats rheumatoid wrong? Lightly there are better products. Results: Patients who were switched from Ventolin CFC during a 3-week run-in encyclopedia. Its mellowly not a quality experience at all. Whats the fellow shamefully panting and panting in a cat without a doctor whom you trust and who understands asthma and relay heater stories of what VENTOLIN was like that sweetly.. Ill check it out tonight and post tomorrow. I wonder why this physio. We used the breathing would cause an attack. Plus the least little thing throws him into a couple of puffs of Ventolin and Intal if I did not help too much, so VENTOLIN was to have lots of people granted ...
Molimo Vas da ovdje postavite linkove na stranice na kojima se nalaze informacije o tretmanu ovisnosti o drogama. Pomozite nam da napravimo najveću bazu linkova i resursa za pomoć osobama koje su ovisne i njihovim bližnjima u regiji ...
The Protective Advantage of Scleral Contact LensesMaria K. Walker OD MS, Patrick Caroline, Beth Kinoshita OD, Matt Lampa OD, Frank Zheng OD, Mark André, Randy Kojima Pacific University College of Optometry, Forest Grove, Oregon
Sekinaka, Yujin; Mitsuiki, Noriko; Imai, Kohsuke; Yabe, Miharu; Yabe, Hiromasa; Mitsui-Sekinaka, Kanako; Honma, Kenichi; Takagi, Masatoshi; Arai, Ayako; Yoshida, Kenichi; Okuno, Yusuke; Shiraishi, Yuichi; Chiba, Kenichi; Tanaka, Hiroko; Miyano, Satoru; Muramatsu, Hideki; Kojima, Seiji; Hira, Asuka; Takata, Minoru; Ohara, Osamu; Ogawa, Seishi; Morio, Tomohiro ...
Walkthrough - FAQ/Walkthrough Walkthrough for Metal Gear Solid 2: Substance Playstation 2: Page 1A Detailed Walkthrough and FAQ for the Playstation 2 Console Game:Metal Gear Solid 2: SubstanceA Hideo Kojima GameWritten By: Patrick G. LoweryCurrent Version: 1.3Date Created: 5 April 2003Last Updated: 8 October 2003`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~`~``First Update: 5 April 2003, 1:22 P.M. ``Version: 0.1 `` ...
Hipersenzitivnost (hipersenzitivna reakcija) su neželjene reakcije koje proizvodi normalni imunski sistem, među kojima su alergije i autoimunost. One mogu da budu štetne, nelagodne, a u nekim slučajevima i fatalne. Za pojavu hipersenzitivnih reakcija je neophodna prethodna imuna senzitacija tela. Klasifikaciju sa četiri grupe su predložili Filip Džordž Hotem Džil i Robin Kombs 1963.[1][2]. ...
... takes the renowned METAL GEAR franchise into exciting new territory by focusing on delivering an all-new action experience unlike anything that has come before. Combining world-class development teams at Kojima Productions and PlatinumGames, MGR REVENGEANCE brings two of the worlds most respected teams together with a common goal of providing players with a fresh synergetic experience that combines the best elements of pure action and epic storytelling, all within the expansive MG universe. The game introduces Raiden as the central character; a child soldier transformed into a half-man, half-machine cyborg ninja, equipped with a high-frequency katana blade and a soul fueled by revenge.. ...
Plazmidi su mali prstenasti molekuli DNK bakterije koji se nalaze izvan hromozoma i replikuju se nezavisno od njega.[1][2] Najznačajniji za čoveka su tzv. R-plazmidi sa genima kojima bakterije stiču otpornost na antibiotike. Zaštitu od antibiotika plazmidi obavljaju tako što: ...
Serijom Radni materijali EIZ-a (EIZ Working Papers) Ekonomski institut, Zagreb želi u najkraćem mogućem vremenu izložiti rezultate istraživanja nastale na znanstvenoistraživačkim projektima ili u okviru drugih aktivnosti suradnika Instituta. Radovi se objavljuju s ciljem poticanja rasprave i kritičkih komentara kojima će se unaprijediti buduće verzije rada ...
TY - JOUR. T1 - The membrane phospholipid binding protein annexin A2 promotes phagocytosis and nonlytic exocytosis of cryptococcus neoformans and impacts survival in fungal infection. AU - Stukes, Sabriya. AU - Coelho, Carolina. AU - Rivera, Johanna. AU - Jedlicka, Anne E.. AU - Hajjar, Katherine A.. AU - Casadevall, Arturo. PY - 2016/8/15. Y1 - 2016/8/15. N2 - Cryptococcus neoformans is a fungal pathogen with a unique intracellular pathogenic strategy that includes nonlytic exocytosis, a phenomenon whereby fungal cells are expunged from macrophages without lysing the host cell. The exact mechanism and specific proteins involved in this process have yet to be completely defined. Using murine macrophages deficient in the membrane phospholipid binding protein, annexin A2 (ANXA2), we observed a significant decrease in both phagocytosis of yeast cells and the frequency of nonlytic exocytosis. Cryptococcal cells isolated from Anxa2-deficient (Anxa2-/-) bone marrow-derived macrophages and lung ...
TY - JOUR. T1 - Annexins family. T2 - Insights into their functions and potential role in pathogenesis of sarcoidosis. AU - Mirsaeidi, Mehdi. AU - Gidfar, Sanaz. AU - Vu, Ann. AU - Schraufnagel, Dean. PY - 2016. Y1 - 2016. N2 - Annexins are Ca2+-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53).. AB - Annexins are Ca2+-regulated phospholipid-binding proteins that play an important role in the cell life cycle, ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010 ...
Principal Investigator:KOJIMA Tetsuhito, Project Period (FY):1994 - 1995, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:血管生物学
Sigma-Aldrich offers abstracts and full-text articles by [Youichi Higuchi, Motohiro Kojima, Genichiro Ishii, Kazuhiko Aoyagi, Hiroki Sasaki, Atsushi Ochiai].
The physiological role of the GH-stimulatory hormone ghrelin, the native substrate for the GH- releasing peptide (GHRP) receptor, is not fully elucidated, but large GH responses are induced by GHRP or ghrelin infusion and this hormone acts synergistically with GHRH (Kojima et al 1999 ...
Michihiro Miyake, Hajime Nakamura, Hironao Kojima, Fumiyuki Marumo; Cation ordering in Co-Mg olivine solid-solution series. American Mineralogist ; 72 (5-6): 594-598. doi: Download citation file:. ...
Sve mambe su visoko otrovne. Njihovi otrovi se uglavnom sastoje od neurotoksina (poznatih kao dendrotoksini). Osim neurotoksina, oni takođe sadrže kardiotoksine[2][3] i fascikuline. Druge komponente mogu da budu kalcikludin, koji je poznata komponenta otrova istočnih zelenih mambi, i kalciseptin, koji je komponenta otrova crne mambe. Toksičnost individualnih primeraka unutar iste vrste i podvrste može znatno da varira u zavisnosti od nekoliko faktora, kao što je geografski region. Čak i metereološke prilike i nadmorska visina mogu da utiču na toksičnost (Ernst and Zug et al. 1996). Ujed može da bude fatalan za ljude kojima nije dotupna odgovarajuća prva pomoć i naknadni tretman, jer njihov otrov zaustavlja pluća i srce. Zapadna zelena mamba (D. viridis), istočna zelena mamba (D. angusticeps), i Džamesonova mamba (D. jamesoni) poseduju otrov sličnog sastava i dejstva sa otrovom crne mambe (D. polylepis). Međutim, njihovi otrovi su manje toksični (po osnovi LD50 studija), ...
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As lake sediments are one of the causes of eutrophication, their removal and effective use has been considered. When they are used as soil in a land, proper permeability is required. However, soil permeability has not completely been understood due to diversity of clays and organic compounds. We clarified permeability characteristics of Lake Kojima sediment, nonswelling clayey soil, by measuring saturated hydraulic conductivity (K). A decrease in K during percolation of dilute electrolyte solution was small when Ca was adsorbed by the soil; K became 3.4×10-5 cm/s at pH 5, 2.9×10-5 cm/s at pH 7, 7.5×10-6 cm/s at pH 9, and 2.3×10-5 cm/s at pH 11 after pure water percolation. Although the permeability tended to decrease as pH increased, K at pH 11 became larger than that at pH 9 due to chemical reaction between soil particles and Ca. On the other hand, when Na was adsorbed, K drastically decreased with pH increase; K became 7.1×10-6 cm/s at pH 5, 3.1×10-6 cm/s at pH 7, 1.7×10-7 cm/s at pH 9, ...
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, ...
There is more than just blood between parent and child. Itto Ogami and his son Daigoro have seen more blood flowing from more bodies than anyone in Edo, but what connects them is their spirit and path. In this collection of classic stories, Itto must protect a young girl after her family is destroyed by a cunning courtesan. Meanwhile, Ittos arch-enemy, Yagyu Retsudo, has sent the civilian police force to round up the Lone Wolf as a common criminal, and before long, Daigoro is coincidentally tangled in a messy pair of crimes. And, most dramatically, Itto returns to the scene of one of his past executions to enter a tender and honorable sword fight against an executed lords former retainer. This volume contains the following stories: Dragnet Night Stalker Cloud Dragon, Wind Tiger Inn of the Last Chrysanthemum Penal Code Article Seventy-Nine
The Annexin family of calcium-binding proteins is composed of al least thirteen mammalian genes (Annexin A1-13). These proteins are characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer binding specificity. The Annexin family
Parkin, Edward and Turner, A J and Hooper, N M (1996) A role for calcium and annexins in the formation of caveolae. Biochemical Society Transactions, 24 (3). 444S. ISSN 0300-5127. Full text not available from this repository ...
Spring 2017 - All Rows (L to R of image): Lisa Chaddock, Robert Kojima, Theresa Carlson, James Covalt, Anna Evashko, Richard Mellinger, Shane Haggard, Peter Friedman, Sharon Wall, Rebecca Vasquez, Jessica Woods, Jamie Hinton, Lorenza Levy, Tim Ziegler, Joseph Avila, Maria Penalosa, Brett Ruston, Benjamin Saylor, Randy Shimabukuro, Ed Sebring, Gerardo Scapaticci, Frank Barish, Soheila Beladi ...
Nicholas J. Leeper, Azad Raiesdana, Yoko Kojima, Ramendra K. Kundu, Henry Cheng, Lars Maegdefessel, Ryuji Toh, G-One Ahn, Ziad A. Ali, D. Ryan Anderson, Clint L. Miller, Scott C. Roberts, Joshua M. Spin, Patricia E. de Almeida, Joseph C. Wu, Baohui Xu, Karen Cheng, Maximilian Quertermous, Soumajit Kundu, Kim E. Kortekaas, Erica Berzin, Kelly P. Downing, Ronald L. Dalman, Philip S. Tsao, Eric E. Schadt, Gary K. Owens, Thomas Quertermous ...
Annexin A5 is a biomarker used in Hiv Infection, Acute Lymphoblastic Leukemia, Hypertension and 942 other diseases. Learn more about Annexin A5.
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport.
Buy ANXA2 recombinant protein, Annexin A2 Recombinant Protein-NP_001002857 (MBS203687) product datasheet at MyBioSource, Recombinant Proteins. Application: SDS-PAGE
Annexin A11 Antibody 10479-2-AP has been identified with IF, IHC, IP, WB, ELISA. 10479-2-AP detected 56-60 kDa band in HeLa cells with 1:500-1:2000 dilution...
Annexin A1 Antibody 66344-1-Ig has been identified with ELISA, IF, IHC, WB. 66344-1-Ig detected 35 kDa band in A431 cells with 1:2500-1:10000 dilution...
Annexin A2 is a calcium-dependent, phospholipid-binding protein found on many cell types. It consists of a short hydrophobic tail (Ser2-Asn32), which dictates its function, and a core domain (Phe33-Asp339), which is involved in phospholipid binding. Annexin A2 has been implicated in a number of biochemical processes, including cell proliferation, foetal immune tolerance, ion-channel activation, cell-cell interactions and the bridging of membranes. Annexin A2 is reported to be a powerful activator of plasminogen and, therefore, is implicated in many normal and pathological processes such as haemostasis and metastasis. Myeloid cell lines are used, extensively, to study many aspects of cellular proliferation, differentiation and function. In the present study, we have used flow cytometry and real-time PCR to investigate the role of annexin A2 expression in the proliferation and differentiation of a number of myeloid cell lines. The results demonstrated that annexin A2 expression was affected when ...
Takahashi N, Kojima T, Kaneko A, Kida D, Hirano Y, Fujibayashi T, Yabe Y, Takagi H, Oguchi T, Miyake H, Kato T, Fukaya N, Hayashi M, Tsuboi S, Kanayama Y, Funahashi K, Hanabayashi M, Hirabara S, Asai S, Yoshioka Y, Ishiguro N. Use of a 12-week observational period for predicting low disease activity at 52 weeks in RA patients treated with abatacept: a retrospective observational study based on data from a Japanese multicentre registry study. Rheumatology (Oxford) 2015;54:854-9 ...
Chris Reutelingsperger is Professor of Biochemistry of Apoptosis at the Cardiovascular Research Institute of Maastricht (CARIM) at Maastricht University. He was senior Research Fellow of the Royal Dutch Academy of Sciences (KNAW). Currently, he is Principal Investigator of the research theme "Vascular Aspects" of CARIM and his research interests focus on annexins in vascular inflammation and remodeling with emphasis on annexin A5. He discovered annexin A5 as a vascular anticoagulant and was the first to see the potential of annexin A5 as a molecular imaging agent to measure cell death. He (co)-authored ,175 peer reviewed papers and is (co)-inventor to 10 granted patents. He is founder and Chairman of the Board of the cross-border Virtual Research Laboratory Euregional PACT in the Flanders-Netherlands Euregion. He is co-founder of 3 Biotech Companies related to annexins in Diagnosis and Therapy. He served at the Board of Directors of Immuno-Designed-Molecules and was Scientific Advisor to Theseus ...
In our hands, the trypsin actually reduced the Annexin staining presumably by stripping off all the phosphotidyl-serine on the surface along with the surface proteins (adhesion molecules). The only time we have seen enhanced annexin is when the cells suffer enough trauma in harvesting that the membrane is not intact and the Annexin gets inside the cell and attaches to the ps on the inner membrane. Julie At 02:11 PM 8/18/98, you wrote: , ,I have a client who is staining with Annexin-FITC. They are looking at ,cell lines and are using trypsin to get the cells off the flasks. We are ,seeing what we think is an exagerated Annexin response. Does anyone out ,there have any feedback on how trypsin affects Annexin staining? Any ,experience and or information about this will be greatly appreciated. , Thanks in advance, , Joan Kalnitsky ,Joan Kalnitsky ,Flow Cytometry Laboratory ,VMRCVM ,(540) 231-4115 ,FAX 540-231-7367 , , It is better to serve than to receive , B. Borg , , , , , ...
|p|Annexin V (or Annexin A5) is a member of the annexin family of intracellular proteins that binds to phosphatidylserine (PS) in a calcium-dependent manner. PS is normally only found on the intracellular leaflet of the plasma membrane in healthy cells, but during early apoptosis, membrane asymmetry
If the ridiculously explosive, fun, entertaining, and incredibly confusing trailer for Metal Gear Solid V: The Phantom Pain wasnt enough to whet your appetite for eyepatched violence, perhaps the announcement that Kiefer Sutherland will voice Snake will do the trick. According to CraveOnline, Konami, in conjunction with Kojima Productions,...
Selepas membuat kajian selama 40 tahun dan semakan semula beribu-ribu jenis sebatian dan lebih 200 jenis herba yang berlainan, Dr. Kojima telah berjaya membangunkan satu-satunya interferon semulajadi di dunia (NutriFeron). Dia telah berjaya menetapkan bahawa ekstrak dari 4 tumbuhan; iaitu biji labu, bunga safflower, Honeysuckle Jepun dan biji Plantago; mempunyai daya kebolehan mendorong pengeluaran semulajadi interferon tubuh. Formulanya yang digunakannya adalah semulajadi, selamat, tulin dan berkesan. Penemuan dan rekaannya telah diiktiraf sebagai penemuan terhebat dalam bidang immunologi ...
BioAssay record AID 590043 submitted by ChEMBL: Induction of apoptosis in human K562 cells assessed as viable cells at 50 nM using annexin V-propidium iodide and annexin V staining by flow cytometry (Rvb = 87.02%).
Page contains details about annexin V conjugated to maleimide-functionalized Feraheme nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Bachem offers H-3196 Annexin A1 (1-25) (dephosphorylated) (human) for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
Annexin A1 is an intracellular calcium/phospholipid-binding protein that is involved in membrane organization and the regulation of the immune system. It has been attributed an anti-inflammatory role at various control levels, and recently we could show that annexin A1 externalization during secondary necrosis provides an important fail-safe mechanism counteracting inflammatory responses when the timely clearance of apoptotic cells has failed. As such, annexin A1 promotes the engulfment of dying cells and dampens the postphagocytic production of proinflammatory cytokines. In our current follow-up study, we report that exposure of annexin A1 during secondary necrosis coincided with proteolytic processing within its unique N-terminal domain by ADAM10. Most importantly, we demonstrate that the released peptide and culture supernatants of secondary necrotic, annexin A1-externalizing cells induced chemoattraction of monocytes, which was clearly reduced in annexin A1- or ADAM10-knockdown cells. Thus, ...
The discovery of an essential role for annexin 11 in cell division is unexpected when considered in the broader context of annexin biology. Although annexins are now firmly implicated in various cellular activities, including endocytosis, calcium signaling, and apoptosis, no member of this protein family has been demonstrated to function in the cell cycle. The membrane binding and vesicle fusogenic properties that define annexins in biochemical terms could provide clues as to the possible role of annexin 11 in the last stage of cytokinesis. Before cells can be completely separated in a process known as abscission, the actomyosin constriction ring at the cleavage furrow has to be disassembled and the central spindle must separate. During this series of events, it is likely that the plasma membrane must be tightly attached to the midbody microtubules for abscission to be successfully completed. CHO1 has previously been suggested to be responsible for this connection (Kuriyama et al., 2002), but ...
Membrane repair is essential to cell survival. In skeletal muscle, injury often associates with plasma membrane disruption. Additionally, muscular dystrophy is linked to mutations in genes that produce fragile membranes or reduce membrane repair. Methods to enhance repair and reduce susceptibility to injury could benefit muscle in both acute and chronic injury settings. Annexins are a family of membrane-associated Ca2+-binding proteins implicated in repair, and annexin A6 was previously identified as a genetic modifier of muscle injury and disease. Annexin A6 forms the repair cap over the site of membrane disruption. To elucidate how annexins facilitate repair, we visualized annexin cap formation during injury. We found that annexin cap size positively correlated with increasing Ca2+ concentrations. We also found that annexin overexpression promoted external blebs enriched in Ca2+ and correlated with a reduction of intracellular Ca2+ at the injury site. Annexin A6 overexpression reduced membrane ...
Copines make up a family of soluble, calcium-dependent membrane binding proteins found in a wide variety of eukaryotic organisms. Copines are characterized as having two C2 domains at the N-terminal region followed by an "A domain," similar to the von Willebrand A (VWA) domain found in integrins, in the C-terminal region [1]. Copines appear to be absent from the Sacchromyces cerevisae genome, while the genomes of Paramecium, Arabidopsis, C. elegans, and human have two, three, five, and nine, respectively [13, 4, 24]. Tomsig and Creutz [8] have hypothesized that copines play a role in calcium signaling by binding to target proteins with their A domains and then bringing those target proteins to a particular membrane through the action of their C2 domains in response to a rise in calcium concentration. Because copines have two C2 domains, they have also been hypothesized to have a role in membrane trafficking. It is possible that both ideas could be correct; copines may provide links between ...
Helen Christians research interests are in the mechanisms of steroid hormone regulation of the pituitary gland, in particular the role of Annexin 1. The Annexins are a well-conserved super-family of structurally related Ca2+ - and phospholipids-binding proteins with wide-ranging functions in health and disease. Annexin 1 is a 37kD protein that is induced by glucocorticoids and mediates glucocorticoid action within the host defence and neuroendocrine systems. Glucocorticoids regulate the synthesis, phosphorylation and cellular disposition of annexin 1, and annexin 1 is implicated in the regulation by these important drugs of pituitary function, the control of cell growth and signal transduction. Most recently her group have characterized a novel secretory pathway of annexin 1, a protein which lacks a signal sequence, involving a member of the ATP binding cassette transporter family, ABCA1. This is the first time the secretion mechanism of an annexin family member has been determined and the ...
Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin A1 protein has an apparent relative molecular mass of 40 kDa with phospholipase A2 inhibitory activity. Glucocorticoids (such as budesonide, cortisol, and beclomethasone) are a class of endogenous or synthetic anti-inflammatory steroid hormones that bind to the glucocorticoid receptor (GR), which is present in almost every vertebrate animal cell. They are used in medicine to treat diseases caused by an overactive immune system, including allergies, asthma, autoimmune diseases, and sepsis. Because they suppress inflammatory pathways, long-term use of glucocorticoid drugs can lead to side-effects such as immunodeficiency and adrenal insufficiency. The main mechanism of ...

Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-Annexin A5 Uptake in Apolipoprotein E-Deficient and Wild-Type...Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-Annexin A5 Uptake in Apolipoprotein E-Deficient and Wild-Type...

0.249 for 18F-FDG and 0.047 for 99mTc-annexin A5 at 25 wk). Conclusion: The accumulation of 18F-FDG and 99mTc-annexin A5 in ... At the ages of 10, 18, and 25 wk (5-15 mice per group at each time point), mice were injected with 18F-FDG or 99mTc-annexin A5 ... At 1 h after 18F-FDG injection (or 2 h after 99mTc-annexin A5 injection), mice were sacrificed, and the aortas were removed for ... Here, we evaluated the aortic uptake of 18F-FDG and 99mTc-annexin A5 in apolipoprotein E-deficient (apoE2/2) and wild-type mice ...
more infohttps://eprints.lib.hokudai.ac.jp/dspace/handle/2115/46755

Annexin A5 - WikipediaAnnexin A5 - Wikipedia

Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect ... Annexin A5 showed upregulation in papillary thyroid carcinoma. Annexin A5 is used as a non-quantitative probe to detect cells ... Annexin A5 forms a shield around negatively charged phospholipid molecules. The formation of an annexin A5 shield blocks the ... The annexin A5 affinity assay typically uses a conjugate of annexin V and a fluorescent or enzymatic label, biotin or other ...
more infohttps://en.wikipedia.org/wiki/Annexin_A5

Annexin A3 - WikipediaAnnexin A3 - Wikipedia

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. It is abnormally expressed in fetuses of both IVF and ICSI ... "Entrez Gene: ANXA3 annexin A3". Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human ... 2005). "Annexin A3 is a potential angiogenic mediator". Biochem. Biophys. Res. Commun. 337 (4): 1283-7. doi:10.1016/j.bbrc. ... "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V". Biochemistry. 35 (6): 1740 ...
more infohttps://en.wikipedia.org/wiki/Annexin_A3

WikiGenes - ANXA3 - annexin A3WikiGenes - ANXA3 - annexin A3

The crystal structure of annexin A8 is similar to that of annexin A3. Réty, S., Sopková-de Oliveira Santos, J., Dreyfuss, L., ... The crystal structure of annexin A8 is similar to that of annexin A3 [17]. ... Annexin A3 is a potential angiogenic mediator. Park, J.E., Lee, d.o. .H., Lee, J.A., Park, S.G., Kim, N.S., Park, B.C., Cho, S ... The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. Favier-Perron, B., Lewit- ...
more infohttps://www.wikigenes.org/e/gene/e/306.html

Anti-Annexin A3/ANXA3 antibody (ab228761) | AbcamAnti-Annexin A3/ANXA3 antibody (ab228761) | Abcam

Rabbit polyclonal Annexin A3/ANXA3 antibody. Validated in WB and tested in Human. Immunogen corresponding to recombinant ... Anti-Annexin A3/ANXA3 antibody. See all Annexin A3/ANXA3 primary antibodies. ... This product Rabbit Anti-Annexin A3/ANXA3 antibody (ab228761) WB Goat Anti-Rabbit IgG H&L (HRP) (ab205718) IHC-P, WB, ELISA, IP ... All lanes : Anti-Annexin A3/ANXA3 antibody (ab228761) at 1/1000 dilution. Lane 1 : A431 (human epidermoid carcinoma cell line) ...
more infohttps://www.abcam.com/annexin-a3anxa3-antibody-ab228761.html

Anxa3 (annexin A3) - Rat Genome DatabaseAnxa3 (annexin A3) - Rat Genome Database

... annexin A3) Alliance Pan paniscus (bonobo/pygmy chimpanzee) : ANXA3 (annexin A3) Canis lupus familiaris (dog) : ANXA3 (annexin ... ANXA3 (annexin A3). NCBI. Ortholog. Mus musculus (house mouse):. Anxa3 (annexin A3). Transitive Ortholog Pipeline. Transitive ... Anxa3 (annexin A3). Transitive Ortholog Pipeline. Transitive Ortholog Pipeline. Sus scrofa (pig):. ANXA3 (annexin A3). ... Homo sapiens (human) : ANXA3 (annexin A3) HGNC Alliance Mus musculus (house mouse) : Anxa3 (annexin A3) MGI Alliance Rattus ...
more infohttps://rgd.mcw.edu/rgdweb/report/gene/main.html?id=8764586

annexin A5 - Semantic Scholarannexin A5 - Semantic Scholar

A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and ... Annexin A5, human. diannexin, human. technetium 99m tricarbonyl His-annexin A5. technetium Tc 99m HYNIC annexin V ... annexin A5. Known as: Calphobindin I, Annexin V, Lipocortin-V (More). A protein of the annexin family isolated from human ... Annexin A5 polymorphism (-1C--,T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. ...
more infohttps://www.semanticscholar.org/topic/annexin-A5/115736

Annexin A3 Antibody (2F3) (NBP2-03373): Novus BiologicalsAnnexin A3 Antibody (2F3) (NBP2-03373): Novus Biologicals

Mouse Monoclonal Anti-Annexin A3 Antibody (2F3). Validated: WB, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Monkey. 100% ... Blogs on Annexin A3. There are no specific blogs for Annexin A3, but you can read our latest blog posts. ... Reviews for Annexin A3 Antibody (NBP2-03373) (0) There are no reviews for Annexin A3 Antibody (NBP2-03373). By submitting a ... Diseases for Annexin A3 Antibody (NBP2-03373). Discover more about diseases related to Annexin A3 Antibody (NBP2-03373). ...
more infohttps://www.novusbio.com/products/annexin-a3-antibody-2f3_nbp2-03373

anxa3 Protein, annexin A3 - Creative BioMartanxa3 Protein, annexin A3 - Creative BioMart

This gene encodes a member of the annexin family.Members of this calcium-dependent phospholipid-binding protein family play a ... Recombinant Human Annexin A3, His-tagged. E. coli. Human. His. +Inquiry. ANXA3-1834H. Recombinant Human Annexin A3. E. coli. ... Annexin III; Annexin-3; AnnexinA3; AnnexinIII; ANX 3; ANX A3; ANX3; ANXA 3; ANXA3_HUMAN; Calcimedin 35 alpha; Inositol 1 2 ... Hamelin-Peyron, C; Vlaeminck-Guillem, V; et al. Prostate cancer biomarker annexin A3 detected in urines obtained following ...
more infohttps://www.creativebiomart.net/symbolsearch_ANXA3.htm

anxa5 Protein, annexin A5 - Creative BioMartanxa5 Protein, annexin A5 - Creative BioMart

Annexin 5 is a;phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in; ... Annexin 5 has also been described as placental;anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin ... The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some;of which ... Recombinant Human Annexin A5, APC. E. coli. Human. N/A. +Inquiry. ANXA5-2624H. Recombinant Human Annexin A5, Biotin. E. coli. ...
more infohttps://www.creativebiomart.net/symbolsearch_ANXA5.htm

Quantitative analysis of self-association and mobility of annexin a4 at the plasma membraneQuantitative analysis of self-association and mobility of annexin a4 at the plasma membrane

Annexin A4 (AnxA4) has been implicated in diverse cellular processes, including the regulation of exocytosis and ion-transport ... Quantitative analysis of self-association and mobility of annexin a4 at the plasma membrane. ... Annexins, found in most eukaryotic species, are cytosolic proteins that are able to bind negatively-charged phospholipids in a ...
more infohttps://repository.ubn.ru.nl/handle/2066/117526

C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...

Annexin A5 Binding to LDL. We observed a strong binding of annexin A5 to the captured oxidized LDL but not to captured native ... It is not known whether annexin A5 binds to LDL and/or interferes with binding of CRP to LDL. Association of annexin A5 with ... Moreover, we show that annexin A5 binds to a site at oxidized LDL different from the CRP binding site and that annexin A5 does ... Enzyme-Linked Immunosorbent Assay for CRP and Annexin A5 Binding to Antigens. Binding of CRP and annexin A5 to LDL was ...
more infohttp://atvb.ahajournals.org/content/25/4/717

In Vivo Monitoring of Parathyroid Hormone Treatment after Myocardial Infarction in Mice with [68Ga]Annexin A5 and [18F...In Vivo Monitoring of Parathyroid Hormone Treatment after Myocardial Infarction in Mice with [68Ga]Annexin A5 and [18F...

Annexin A5 positron emission tomography (PET) reveals the externalization of phosphatidylserine as a surrogate marker for ... 68Ga]Annexin A5 uptake was 7.4 ± 1.3 %ID/g within the infarction for the controls and 4.5 ± 1.9 %ID/g for the PTH group (p = . ... 68Ga]Annexin A5 PET can detect the effects of PTH treatment as a marker of apoptosis 2 days after MI; ex vivo examination ... Abstract[68Ga]Annexin A5 positron emission tomography (PET) reveals the externalization of phosphatidylserine as a surrogate ...
more infohttp://www.biomedsearch.com/nih/In-Vivo-Monitoring-Parathyroid-Hormone/25249170.html

Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization | Murdoch...Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization | Murdoch...

Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization. Pubmed ID ... Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization. Journal ...
more infohttps://www.mcri.edu.au/publications/depletion-annexin-a5-annexin-a6-and-collagen-x-causes-no-gross-changes-matrix-vesicle

Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without...Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without...

Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without ... on a blood test called the annexin A5 (AnxA5) resistance assay in people with antiphospholipid antibodies (aPL). People with ...
more infohttps://www.hss.edu/clinical-trials_antiphospholipid-syndrome-lupus-hydroxychloroquine.asp

Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat...Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat...

Human annexin A5 is a ubiquitous protein implicated in diverse signal transduction processes associated with cell growth and ... Promoter transcriptional activity was determined for a wide 5′ portion of the human annexin A5 gene, from bp −1275 to +79 ... Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat ... Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat ...
more infohttp://www.biochemj.org/content/356/2/571

99mTc-(CO)3 His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window...99mTc-(CO)3 His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window...

The apoptosis-detecting radiotracer Tc-99m-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the ... The apoptosis-detecting radiotracer Tc-99m-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the ... SPECT analyses demonstrated a significant increase in tumoral Tc-99m-(CO)(3) His-annexin A5 uptake 4 d after bevacizumab ... SPECT analyses demonstrated a significant increase in tumoral Tc-99m-(CO)(3) His-annexin A5 uptake 4 d after bevacizumab ...
more infohttps://biblio.ugent.be/publication/2141566

Annexin A5 Polyclonal Antibody | EpiGentekAnnexin A5 Polyclonal Antibody | EpiGentek

Description Annexin A5 Polyclonal Antibody. Unconjugated. Raised in Rabbit. Formulation Liquid. 0.03% Proclin 300,... ... Home » Antibodies » Primary Antibodies » Cell Structure & Function Antibodies » Apoptosis & Cell Death Antibodies » Annexin A5 ... Recombinant Cynops pyrrhogaster Annexin A5 protein (1-323AA). Storage. Shipped at 4°C. Upon delivery aliquot and store at -20°C ... Annexin A5 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.. Formulation. Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M ...
more infohttps://www.epigentek.com/catalog/annexin-a5-polyclonal-antibody-p-5439.html?currency=ww

Panorama Dashboard: /Panorama Public/2016/Barr-Gillespie - Annexin A5Panorama Dashboard: /Panorama Public/2016/Barr-Gillespie - Annexin A5

The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse ... Annexin A5 is the Most-Abundant Membrane-Associated Protein in Stereocilia but is Dispensable ... GILL185_ANXA5_Ca2vsNoCa2_bundle_TGT2_DATA_Annexins_2016-03-18_16-08-41.sky.zip. (2 MB). 2016-03-23. 6. 27. 30. 167. 8. ... Annexins have been proposed to mediate Ca2+-dependent repair of membrane lesions, which could be part of the repair mechanism ...
more infohttps://panoramaweb.org/project/Panorama%20Public/2016/Barr-Gillespie%20-%20Annexin%20A5/begin.view

Gentaur Molecular :EIAab \ ELISA kit  35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I...Gentaur Molecular :EIAab \ ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I...

Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Pig,Placental anticoagulant ... ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II, ... ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II, ... Product name : ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV ...
more infohttp://www.antibody-antibodies.com/product2767227-search-ELISA_kit__35_beta_calcimedin,Annexin_A4,Annexin_IV,Annexin_4,ANX4,ANXA4,Chromobindin_4,Endonexin_I,Lipocortin_IV,P32.5,PAP_II,Pig,Placental_anticoagulant_protein_II,PP4_X,Protein_II,Sus_scrofa.html

Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and...Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and...

Krey, J. F., Drummond, M., Foster, S., Porsov, E., Vijayakumar, S., Choi, D., ... Barr-Gillespie, P. (2016). Annexin A5 is the ... Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and ... Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and ... Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and ...
more infohttps://ohsu.pure.elsevier.com/en/publications/annexin-a5-is-the-most-abundant-membrane-associated-protein-in-st

Annexin A5 polymorphism (-1C--|T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome.  - PubMed -...Annexin A5 polymorphism (-1C--|T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. - PubMed -...

Annexin A5 polymorphism (-1C--,T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome.. de Laat B1 ... Annexin A5 (ANX‐A5) plasma concentration in measured plasma. ANX‐A5 levels were measured with "a sandwich‐ELISA‐type" assay. ... To investigate whether anti-annexin A5 immunoglobulin (Ig)M or IgG antibodies, or the -1C--,T polymorphism of annexin A5, is a ... Annexin A5 polymorphism (−1C→T) and the presence of anti‐annexin A5 antibodies in the antiphospholipid syndrome ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=20104

A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic...A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic...

... annexin A2, and annexin A3. Calreticulin, annexin A2, and annexin A3 are very likely a panel of biomarkers with potential value ... annexin A2, annexin A3 and haptoglobin. The data of western blot and immunohistochemical analysis are consistent with the 2-DE ... annexin A2 and annexin A3 between the urine and tumor tissues of UTUC patients. CALR, annexin A2 and annexin A3 are very likely ... annexin A3 (spot 29) and Hp (spot 32 ~ 36). Side-by-side comparisons of CALR, ZAG, annexin A2, annexin A3 and Hp showed the ...
more infohttps://0-bmccancer-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2407-14-363

Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and...Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and...

Annexin A5 (ANXA5) has been suggested to possess antiatherogenic properties. We investigated whether ANXA5 genetic variations ... Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and ... Annexin A5 gene; Atherosclerosis; Cardiovascular disease; Carotid intima-media thickness; Familial hypercholesterolemia; ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=102258

Cardiovascular molecular imaging of apoptosis | SpringerLinkCardiovascular molecular imaging of apoptosis | SpringerLink

Annexin A5 has been more widely used to target PS exposure. Hiller and co-workers [54] recently reported on a new Anx A5-based ... This molecular imaging protocol is based upon the protein annexin A5 (Anx A5), which binds with high selectivity and with great ... Annexin A5. In the past decade, a molecular imaging protocol was established to detect and measure apoptosis in vitro and in ... The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical ...
more infohttps://link.springer.com/article/10.1007%2Fs00259-007-0443-0
  • Here, we evaluated the aortic uptake of 18F-FDG and 99mTc-annexin A5 in apolipoprotein E-deficient (apoE2/2) and wild-type mice placed on high-fat diets. (hokudai.ac.jp)
  • Aortic tracer uptake [(ID%/g) · kg] remained stable with the regular diet in wild-type mice (0.054- 0.053 and 0.021-0.023 for 99mTc-annexin A5) but increased with cholesterol feeding in wild-type mice (0.164 for 18F-FDG and 0.036 for 99mTc-annexin A5 at 25 wk) and in apoE2/2 mice (0.249 for 18F-FDG and 0.047 for 99mTc-annexin A5 at 25 wk). (hokudai.ac.jp)
  • At the ages of 10, 18, and 25 wk (5-15 mice per group at each time point), mice were injected with 18F-FDG or 99mTc-annexin A5 after 12 h of fasting. (hokudai.ac.jp)
  • At 1 h after 18F-FDG injection (or 2 h after 99mTc-annexin A5 injection), mice were sacrificed, and the aortas were removed for welltype scintillation counting of radioactivity. (hokudai.ac.jp)
  • Combined the experimental data in the urine and in tumor tissues collected from patients with UTUC, the crucial over-expressed proteins are calreticulin, annexin A2, and annexin A3. (beds.ac.uk)
  • In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. (wikipedia.org)
  • Annexin A5 is used as a non-quantitative probe to detect cells that have expressed phosphatidylserine (PS) on the cell surface, an event found in apoptosis as well as other forms of cell death. (wikipedia.org)
  • The apoptosis-detecting radiotracer Tc-99m-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the start of the irinotecan or NaCl treatment, and micro-SPECT was subsequently performed 3.5 h after injection of the radiotracer. (ugent.be)
  • The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (springer.com)
  • The annexin A5 affinity assay typically uses a conjugate of annexin V and a fluorescent or enzymatic label, biotin or other tags, or a radioelement, in a suitable buffer (annexin V binding to aminophospholipids is Ca2+ dependent). (wikipedia.org)
  • The assay combines annexin V staining of PS and PE membrane events with the staining of DNA in the cell nucleus with propidium iodide (PI) or 7-Aminoactinomycin D (AAD-7), distinguishing viable cells from apoptotic cells and necrotic cells. (wikipedia.org)
  • Methods and Results- We found that CRP and annexin A5 at physiological concentrations bind Ca ++ dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL. (ahajournals.org)
  • In Vivo Monitoring of Parathyroid Hormone Treatment after Myocardial Infarction in Mice with [68Ga]Annexin A5 and [18F]Fluorodeoxyglucose Positron Emission Tomography. (biomedsearch.com)
  • At the ages of 10, 18, and 25 wk (5-15 mice per group at each time point), mice were injected with 18F-FDG or 99mTc-annexin A5 after 12 h of fasting. (hokudai.ac.jp)
  • At 1 h after 18F-FDG injection (or 2 h after 99mTc-annexin A5 injection), mice were sacrificed, and the aortas were removed for welltype scintillation counting of radioactivity. (hokudai.ac.jp)
  • The discovery of a downstream element crucial for annexin A5 gene transcription, and its interaction with a potentially novel transcription factor or complex, may provide a clue to understanding the initiation of transcription by TATA-less, multiple start site promoters. (biochemj.org)
  • Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and cardiovascular disease risk. (cdc.gov)
  • Conclusion: The accumulation of 18F-FDG and 99mTc-annexin A5 in aortic tissues is influenced not only by the progression of atherosclerotic disease but also by cholesterol loading over time. (hokudai.ac.jp)
  • 16,17 In healthy, lean individuals, annexin A5 circulates at low concentrations in plasma (0.03 to 0.15 nmol/L, ie, 1 to 5 ng/mL). (ahajournals.org)
  • ANX‐A5 plasma concentrations are displayed as median (interquartile range). (cdc.gov)
  • Increased plasma levels of annexin A5 were observed in patients with acute myocardial infarction or unstable angina, 18 and abundant expression is observed in atherosclerotic lesions of coronary arteries. (ahajournals.org)
  • T mutation in the annexin A5 gene (46/198 patients) was significantly associated with miscarriage (odds ratio 2.7, 95% confidence interval 1.1 to 6.7, independent risk factor). (cdc.gov)
  • Western blotting analysis and immunohistochemistry of tumor tissues and normal tissues from patients with UTUC were carried out to further verify five possible UTUC biomarkers, including zinc-alpha-2-glycoprotein, calreticulin, annexin A2, annexin A3 and haptoglobin. (beds.ac.uk)