Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Annexin A2: A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.Annexin A1: Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.Annexin A6: Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Scientific Misconduct: Intentional falsification of scientific data by presentation of fraudulent or incomplete or uncorroborated findings as scientific fact.Annexin A4: Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.beta 2-Glycoprotein I: A 44-kDa highly glycosylated plasma protein that binds phospholipids including CARDIOLIPIN; APOLIPOPROTEIN E RECEPTOR; membrane phospholipids, and other anionic phospholipid-containing moieties. It plays a role in coagulation and apoptotic processes. Formerly known as apolipoprotein H, it is an autoantigen in patients with ANTIPHOSPHOLIPID ANTIBODIES.Antibodies, Bacterial: Immunoglobulins produced in a response to BACTERIAL ANTIGENS.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Phosphatidylcholines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.Lipoproteins, LDL: A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Cytomegalovirus: A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Cytomegalovirus Infections: Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.

Differential effects of annexins I, II, III, and V on cytosolic phospholipase A2 activity: specific interaction model. (1/23)

Annexins (ANXs) are a family of proteins with calcium-dependent phospholipid binding properties. Although inhibition of phospholipase A2 (PLA2) by ANX-I has been reported, the mechanism is still controversial. Previously we proposed a 'specific interaction' model for the mechanism of cytosolic PLA2 (cPLA2) inhibition by ANX-I [Kim et al., FEBS Lett. 343 (1994) 251-255]. Here we have studied the cPLA2 inhibition mechanism using ANX-I, N-terminally deleted ANX-I (DeltaANX-I), ANX-II, ANX-II(2)P11(2), ANX-III, and ANX-V. Under the conditions for the specific interaction model, ANX-I, DeltaANX-I, and ANX-II(2)P11(2) inhibited cPLA2, whereas inhibition by ANX-II and ANX-III was negligible. Inhibition by ANX-V was much smaller than that by ANX-I. The protein-protein interactions between cPLA2 and ANX-I, DeltaANX-I, and ANX-II(2)P11(2) were verified by immunoprecipitation. We can therefore conclude that inhibition of cPLA2 by specific interaction is not a general function of all ANXs, and is rather a specific function of ANX-I. The results are consistent with the specific interaction model.  (+info)

Ca(2+) and membrane binding to annexin 3 modulate the structure and dynamics of its N terminus and domain III. (2/23)

Annexin 3 (ANX A3) represents approximately 1% of the total protein of human neutrophils and promotes tight contact between membranes of isolated specific granules in vitro leading to their aggregation. Like for other annexins, the primary molecular events of the action of this protein is likely its binding to negatively charged phospholipid membranes in a Ca(2+)-dependent manner, via Ca(2+)-binding sites located on the convex side of the highly conserved core of the molecule. The conformation and dynamics of domain III can be affected by this process, as it was shown for other members of the family. The 20 amino-acid, N-terminal segment of the protein also could be affected and also might play a role in the modulation of its binding to the membranes. The structure and dynamics of these two regions were investigated by fluorescence of the two tryptophan residues of the protein (respectively, W190 in domain III and W5 in the N-terminal segment) in the wild type and in single-tryptophan mutants. By contrast to ANX A5, which shows a closed conformation and a buried W187 residue in the absence of Ca(2+), domain III of ANX A3 exhibits an open conformation and a widely solvent-accessible W190 residue in the same conditions. This is in agreement with the three-dimensional structure of the ANX A3-E231A mutant lacking the bidentate Ca(2+) ligand in domain III. Ca(2+) in the millimolar concentration range provokes nevertheless a large mobility increase of the W190 residue, while interaction with the membranes reduces it slightly. In the N-terminal region, the W5 residue, inserted in the central pore of the protein, is weakly accessible to the solvent and less mobile than W190. Its amplitude of rotation increases upon binding of Ca(2+) and returns to its original value when interacting with membranes. Ca(2+) concentration for half binding of the W5A mutant to negatively charged membranes is approximately 0.5 mM while it increases to approximately 1 mM for the ANX A3 wild type and to approximately 3 mM for the W190 ANX A3 mutant. In addition to the expected perturbation of the W190 environment at the contact surface between the protein and the membrane bilayer, binding of the protein to Ca(2+) and to membranes modulates the flexibility of the ANX A3 hinge region at the opposite of this interface and might affect its membrane permeabilizing properties.  (+info)

Calcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatin on bone. (3/23)

In vitro treatment with a pharmacological dose of simvastatin, a potent pro-drug of a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, stimulates bone formation. In our study, simvastatin stimulated differentiation of osteoblasts remarkably in a dose-dependent manner, with minimal effect on proliferation. To identify the mediators of the anabolic effects of simvastatin on osteoblasts, we tried to identify and characterize simvastatin-induced proteins by using proteomic analysis. Calcyclin was significantly up-regulated by more than 10 times, and annexin I was also up-regulated by simvastatin. However, annexin III, vimentin, and tropomyosin were down-regulated. Up-regulated calcyclin mRNA by simvastatin was validated by reverse transcription in mouse calvarial cells. In confocal microscope analysis, green fluorescence protein-calcyclin fusion protein was ubiquitously observed in the of MC3T3-E1 cells transfected with green fluorescence protein-calcyclin cDNA containing plasmid and was quickly concentrated in the nucleus 20 min after simvastatin treatment. Overexpression of calcyclin cDNA stimulated both the proliferation and expression of alkaline phosphatase mRNA significantly, without exposure to simvastatin in MC3T3-E1 cells. However, both the rate of proliferation of the osteoblasts and the expression of alkaline phosphatase mRNA were suppressed significantly 1 day after treatment with the calcyclin-specific small interference RNA, and furthermore, simvastatin did not overcome this suppression in the small interference RNA-pretreated MC3T3-E1 cells. In conclusion, calcyclin is one of the candidate proteins that plays a role in osteoblastogenesis in response to simvastatin, although the precise functions of calcyclin in osteoblast remain to be verified.  (+info)

Isolated small rat hepatocytes express both annexin III and terminal differentiated hepatocyte markers, tyrosine aminotransferase and tryptophan oxygenase, at the mRNA level. (4/23)

We recently showed that annexin III is expressed in isolated small rat hepatocytes but, not in parenchymal hepatocytes. In the present study, we used reverse transcription polymerase chain analysis to examine the annexin III mRNA level in isolated small rat hepatocytes and parenchymal hepatocytes. Annexin III mRNA was detected in isolated small hepatocytes, but not in isolated parenchymal hepatocytes, confirming the presence of annexin III expression in isolated small rat hepatocytes at the mRNA level and indicating that the absence of annexin III expression in isolated parenchymal hepatocytes is due to the absence of annexin III mRNA. Furthermore, we examined the mRNA level of tyrosine aminotransferase and tryptophan oxygenase, two terminally differentiated hepatocyte markers. mRNA for these markers was detected in both parenchymal hepatocytes and small hepatocytes.  (+info)

Expression of annexin A3 in primary cultured parenchymal rat hepatocytes and inhibition of DNA synthesis by suppression of annexin A3 expression using RNA interference. (5/23)

Annexin A3 is a member of the lipocortin/annexin family, which binds to phospholipids and membranes in a Ca(2+)-dependent manner. Although annexin A3 has various functions in vitro, its cellular significance is completely unknown. Annexin A3 is not found in rat liver in vivo. In the present study, we investigated the expression of annexin A3 in primary cultured parenchymal rat hepatocytes. Annexin A3 protein was detected in 48-h, but not 2.5-h, cultured hepatocytes using Western blot analysis. The annexin A3 level further increased after an additional 24 h of culture. Annexin A3 mRNA was not detected in 2.5-h cultured hepatocytes but was detected 22 h after the start of culture by RT-PCR analysis, reaching a maximum value after 48 h of culture. To define the role of Annexin A3 in DNA synthesis, RNA interference was used to reduce annexin III gene expression in hepatocytes. The transfection of small interfering RNAs targeting annexin A3 in the hepatocytes reduced the corresponding mRNA and protein expression by approximately 80% and more than 90%, respectively, at 24 h after transfection. In the annexin A3 small interfering RNAs-transfected cells, DNA synthesis, as assessed by [3H]thymidine incorporation, decreased by approximately 70% not only in the control cultures, but also in the hepatocyte growth factor- or epidermal growth factor-treated cells. These findings show that annexin A3 is expressed in primary cultured parenchymal rat hepatocytes and that the suppression of annexin A3 expression using RNA interference inhibits DNA synthesis.  (+info)

Change in annexin A3 expression by regulatory factors of hepatocyte growth in primary cultured rat hepatocytes. (6/23)

We have recently reported that annexin (Anx) A3 expression is necessary for hepatocyte growth in cultured rat hepatocytes seeded at half the subconfluent density on collagen. In the present study, we investigated the effects of various regulatory factors of hepatocyte growth on AnxA3 expression. AnxA3 expression was significantly reduced in hepatocytes cultured under various growth inhibitory conditions such as presence of dexamethasone, culture at subconfluent cell density, and on EHS-Matrigel and lactose-carrying styrene polymer. On the other hand, hepatocyte growth factor and epidermal growth factor, stimulators of hepatocyte growth, significantly increased AnxA3 expression in hepatocytes cultured on EHS-Matrigel. These results show close correlation between known stimulatory or inhibitory actions of various factors to hepatocyte growth and increase or decrease in AnxA3 expression, and suggest the involvement of AnxA3 in their regulation of hepatocyte growth.  (+info)

Annexin A3-expressing cellular phenotypes emerge from necrotic lesion in the pericentral area in 2-acetylaminofluoren/carbon tetrachloride-treated rat livers. (7/23)

Recently we found a small hepatocyte-specific protein, annexin A3 (AnxA3), in fractionated adult rat hepatocytes. Here we describe the results of an in vivo demonstration of AnxA3-expressing cellular phenotypes in the liver with 2-acetylaminofluoren (2-AAF)/carbon tetrachloride (CCl(4))-injury. In association with an elevation of alanine amino transferase (ALT) and aspartic acid amino transferase (AST) activities, hepatic AnxA3 mRNA increased markedly. AnxA3-positive cells were detected in clustered cells present in or emerging from the pericentral region. These albumin-expressed cells were histologically similar to cells expressing CD34, a hematopoietic cell marker protein. The number of clusters decreased in the days following CCl(4) treatment, and annexin-negative, but albumin-positive, oval cells appeared. We concluded that the agent-induced liver defect initially recruits bone marrow-derived cells, and that it promotes differentiation of these cells into AnxA3-positive cells, followed by emergence of the oval cells, which might have a role in the restitution of the damaged liver.  (+info)

Annexin A3 expression after stroke in the aged rat brain. (8/23)

In an effort to identify new proteins involved in functional recovery after cerebral ischemia, young (3 months) and aged (18 months) male rats were subjected to middle cerebral artery (MCA) occlusion. Brains were harvested at 3- and 14-days post ischemia and proteins from the peri-infarcted and the corresponding contralateral area and total proteins were analyzed by two-dimensional polyacrylamide gel electrophoresis followed by mass spectrometry analysis. Annexin A3 (ANXA3) was identified as one upregulated protein in the post-ischemic rat brain. Using western blotting, real-time PCR and immunohistochemistry, we confirmed that at 3-14 days post-stroke, ANXA3 expression in the peri-infarct area was consistently increased over the corresponding area of control rats. Double staining revealed that ANXA3 is produced by activated microglial cells. We found that aged rats also had more newly proliferating cells expressing ANXA3 than young rats do. Occasionally, ANXA3-immunopositive cells wraped around neurons, suggesting that annexin A3 may be involved in the removal of dying neurons after stroke.  (+info)

*Annexin A5

... (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect ... Annexin A5 showed upregulation in papillary thyroid carcinoma. Annexin A5 is used as a non-quantitative probe to detect cells ... Annexin A5 forms a shield around negatively charged phospholipid molecules. The formation of an annexin A5 shield blocks the ... The annexin A5 affinity assay typically uses a conjugate of annexin V and a fluorescent or enzymatic label, biotin or other ...

*Annexin A3

... is a protein that in humans is encoded by the ANXA3 gene. It is abnormally expressed in fetuses of both IVF and ICSI ... "Entrez Gene: ANXA3 annexin A3". Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human ... 2005). "Annexin A3 is a potential angiogenic mediator". Biochem. Biophys. Res. Commun. 337 (4): 1283-7. doi:10.1016/j.bbrc. ... "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V". Biochemistry. 35 (6): 1740 ...

*Annexin A4

... is a protein that in humans is encoded by the ANXA4 gene. Annexin IV (ANX4) belongs to the annexin family of calcium ... "Entrez Gene: ANXA4 annexin A4". Human ANXA4 genome location and ANXA4 gene details page in the UCSC Genome Browser. Römisch J, ... Dreier R, Schmid KW, Gerke V, Riehemann K (Aug 1998). "Differential expression of annexins I, II and IV in human tissues: an ... Han EK, Tahir SK, Cherian SP, Collins N, Ng SC (Jul 2000). "Modulation of paclitaxel resistance by annexin IV in human cancer ...

*Annexin A5 affinity assay

This clustering of annexin A5 on the membrane greatly increases the intensity of annexin A5 when labeled with a fluorescent or ... Labeling of annexin A5 with fluorescent or radioactive molecules makes it possible to detect binding of labeled annexin A5 to ... Internalization amplifies additionally the intensity of the annexin A5 stained cell. Annexin A5 has been used to successively ... annexin A5 assembles into a trimeric cluster. This trimer consists of three annexin A5 molecules that are bound to each other ...

*Antiphospholipid syndrome

Annexin A5 forms a shield around negatively charged phospholipid molecules, thus reducing their availability for coagulation. ... Thus, anti-annexin A5 antibodies increase phospholipid-dependent coagulation steps. The Lupus anticoagulant antibodies are ...

*Integrin, beta 5

... has been shown to interact with PTK2, Annexin A5 and PAK4. Elevated levels of ITGB5 have been found in ... "Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V". Mol. Cell. United States. ...

*Kinase insert domain receptor

Annexin A5 and SHC1. Cluster of differentiation VEGF receptors Holmes K, Roberts OL, Thomas AM, Cross MJ (October 2007). " ...

*Annexin

However some annexins (Annexin A1, Annexin A2, and Annexin A5) have also been found outside the cellular environment, for ... Annexin, type I InterPro: IPR002388 Annexin, type II InterPro: IPR002389 Annexin, type III InterPro: IPR002390 Annexin, type IV ... In addition to annexin A-II, annexin A-XI has also been shown to organize cell membrane properties. Annexin A-XI is believed to ... The 310 amino acid annexin core has four annexin repeats, each composed of 5 alpha-helices. The exception is annexin A-VI that ...

*Annexin Pharmaceuticals

The concept for the therapy is based on the anti-inflammatory properties of Annexin A5, a body own protective protein that acts ... Annexin Pharmaceuticals is a Swedish privately held biotech company developing new therapeutic approaches for inflammatory ... http://www.solidinfo.se/foretag/annexin-pharmaceuticals-ab/personer. ... "Annexin: Attenuating vascular inflammation" (PDF). BioCentury: A18. Retrieved 1 February 2015. ...

*Flow cytometry

Annexin A5 affinity assay, a test for cells undergoing apoptosis, often uses flow cytometry Cell cycle analysis Coulter counter ...

*List of MeSH codes (D12.776.157)

Annexin A3 MeSH D12.776.157.125.050.080 -- annexin a4 MeSH D12.776.157.125.050.100 -- annexin a5 MeSH D12.776.157.125.050.110 ... annexin a6 MeSH D12.776.157.125.050.120 -- annexin a7 MeSH D12.776.157.125.412.249 -- calmodulin MeSH D12.776.157.125.412.311 ... annexin a1 MeSH D12.776.157.125.050.060 -- annexin a2 MeSH D12.776.157.125.050.070 -- ...

*List of MeSH codes (D08)

... annexin A3 MeSH D08.811.277.352.640.125 --- 3',5'-cyclic-GMP phosphodiesterase MeSH D08.811.277.352.640.150 --- 3',5'-cyclic- ... cytochromes a3 MeSH D08.244.187.249 --- cytochromes b MeSH D08.244.187.500 --- cytochromes b5 MeSH D08.244.187.600 --- ...

*A3

... regulatory sequence, a sequence for the insulin gene Adenosine A3 receptor, a human gene Annexin A3, a human gene ATC code ... a band known as A3 in the U.S. to avoid confusion with the country group Alabama A-3, a Yamaha musical instrument product A3 ... a club football tournament also known as the East Asian Champions Cup Arrows A3, a 1980 racing car A3, a climbing Grade A-3 ... a British Isles plants community Gibberellin A3, a plant hormone HLA-A3, a Human MHC Serotype HLA-A Subfamily A3, a rhodopsin- ...

*A5

... and variants may refer to: A5 regulatory sequence in biochemistry Annexin A5, a human cellular protein ATC code A05 Bile and ... see section Military Chery A5, a 2006 Chinese car Audi A5, a 2007 luxury coupé Arrows A5, a 1982 British racing car A5 road, in ... the Apple mobile microprocessor ARM Cortex-A5, ARM applications processor A5/1, A5/2 and A5/3, ciphers used in cellular phones ... A-5, an export version of Nanchang Q-5, a Chinese-built jet fighter bomber Curtiss Falcon or A-5 Falcon, an attack aircraft ...

*S100A10

Annexin II, which is attracted to negatively charged phospholipids, binds to p11 at the Ca2+ binding site. In addition, Annexin ... "Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer ... Kwon M, MacLeod TJ, Zhang Y, Waisman DM (Jan 2005). "S100A10, annexin A2, and annexin a2 heterotetramer as candidate ... The p11 and annexin II complex is regulated by the phosphorylation of SerII on the annexin II molecule by protein kinase C (PKC ...

*Formyl peptide receptor 3

Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN (May 1997). "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 ... Ernst S, Lange C, Wilbers A, Goebeler V, Gerke V, Rescher U (Jun 2004). "An annexin 1 N-terminal peptide activates leukocytes ... "The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is ... is not affected by lipoxin A4". Scandinavian Journal of Immunology. 56 (5): 470-6. doi:10.1046/j.1365-3083.2002.01149.x. PMID ...

*Proliferating cell nuclear antigen

Annexin A2, CAF-1, CDC25C, CHTF18, Cyclin D1, Cyclin O, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1C, DNMT1 ... E3 ubiquitin ligases • E2 SUMO-conjugating enzyme • Helicases, ATPases • Mismatch repair enzymes • Base excision repair enzymes ...

*Human papillomavirus infection

The HPV genome is composed of six early (E1, E2, E4, E5, E6, and E7) open-reading frames (ORF), two late (L1 and L2) ORFs, and ... and annexin A2 leading to entry of the virions into basal epithelial cells through clathrin-mediated endocytosis and/or ... "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLoS One. 7 (8): ...

*Formyl peptide receptor 2

... lipoxin A4 (LXA4). Because of its interaction with lipoxin A4, FPR2 is also commonly named the ALX/FPR2 or just ALX receptor. ... Ac2-26 and Ac9-25 of Annexin A1 (ANXA1 or lipocortin 1), which at high concentrations fully stimulate neutrophil functions but ... "Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 ... lipoxin A4 (LXA4), and thereafter for a related arachidonic acid metabolite, the Epi-lipoxin, aspirin-triggered lipoxin A4 (i.e ...

*Housekeeping gene

018229 ANXA6 Annexin 6 ANXA7 Annexin 7 AP1B1 Coated vessicles CLTA Clathrin A (vessicles) CLTB Clathrin B (vessicles) CLTC MTX2 ... 021178 E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression ... 003334 Homo sapiens ubiquitin-activating enzyme E1 (A1S9T and BN75 temperature UBA2 NM_005499 UBA3 NM_003968 UBA5 NM_024818 ...

*Specialized pro-resolving mediators

These products are now termed lipoxin A4 and B4, respectively. While initially found to have in vitro activity suggesting that ... annexin A1 (an inhibitor of formation of pro-inflammatory metabolites of polyunsaturated fatty acids), and the gaseous ...

*Ubiquitin C

He KL, Deora AB, Xiong H, Ling Q, Weksler BB, Niesvizky R, Hajjar KA (July 2008). "Endothelial cell annexin A2 regulates ... "Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy". Proceedings of the ... "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Molecular Cell ... "Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated ...

*Formyl peptide receptor 1

Takano T, Fiore S, Maddox JF, Brady HR, Petasis NA, Serhan CN (May 1997). "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 ... Annexin A1 (also termed ANXA1 and lipocortin 1) and its N-terminal peptides (Ac2-26 and Ac9-25). At low concentrations, these ... FMLP and lipoxin A4. Isolated mouse Olfactory bulb neurons also respond to a range of other fpr agonists. These results suggest ... and functional characterization of a murine lipoxin A4 receptor homologue gene". Journal of Immunology. 169 (6): 3363-9. doi: ...

*Estrogen

The three major naturally occurring forms of estrogen in women are estrone (E1), estradiol (E2), and estriol (E3). Another type ... Nadkarni S, Cooper D, Brancaleone V, Bena S, Perretti M (November 2011). "Activation of the annexin A1 pathway underlies the ... The three major naturally occurring estrogens in women are estrone (E1), estradiol (E2), and estriol (E3). Estradiol is the ... A4), androstenediol (A5), 3α-androstanediol, and 3β-androstanediol. Some estrogen metabolites, such as the catechol estrogens 2 ...
Mouse anti Human Annexin A3 antibody, clone 4F1 recognizes human annexin A3, also known as Annexin III, Inositol 1,2-cyclic phosphate 2-ph
The invention provides a novel method for the chemical synthesis of 2′,3′-cyclic phosphate and phosphorothioate of mono and terminated oligonucleotides synthesis. The invention also provides a novel method of for the chemical synthesis of 2′,3′- and 3′,5′-cyclic phosphate and phosphorothioate mononucleotide nucleotides. The process is based on quick and efficient cyclization of phosphoramidate moiety and neighboring hydroxyl group. The present invention is directed towards the synthesis of high purity DNA and RNAs, specifically to introduce cyclic phosphate at 3′-end of oligonucleotides. Such DNA and RNAs have extensive application in therapeutics, diagnostics, drug design, and selective inhibition of an RNA sequence within cellular environment, in pre-tRNA cleavage and in ribozyme ligation. The 2′,3′-cyclic phosphate nucleosides are involved in a vast number of applications in molecular biology in general and mammalian cells in particular. The invention also envisions providing kits
Annexin III antibody [1A9] (Annexin A3) for FACS, WB. Anti-Annexin III mAb (GTX84883) is tested in Human, Dog, Monkey, Rat samples. 100% Ab-Assurance.
BACKGROUND AND OBJECTIVE: Proteinuria assessment is key in investigating chronic kidney disease (CKD) but uncertainty exists regarding optimal methods. Albuminuria, reflecting glomerular damage, is usually measured, but non-albumin proteinuria (NAP), reflecting tubular damage, may be important. This study investigated the prevalence and associations of albuminuria and NAP, and the optimum number of urine specimens required. METHODS: 1,741 patients with CKD stage 3, recruited from primary care, underwent medical history, clinical assessment, blood sampling, and submitted three early morning urine samples for albumin to creatinine ratio (uACR) and protein to creatinine ratios (uPCR). Albuminuria was defined as uACR ≥ 3 mg/mmol in at least two of three samples. Isolated NAP was defined as uPCR ≥ 17 mg/mmol in two of three samples and uACR ,3 mg/mmol in all three. Prevalence and associations of albuminuria and NAP, degree of agreement between single uACR and average of three uACRs, and urine ...
Anexina A3 é uma proteína que nos humanos é codificada pela gene ANXA3. É expressada de maneira anormal em fetos derivados de fertilização in vitro e de microinjecção intracitoplasmática, podendo contribuir para um risco aumentado de defeitos no recém-nascido nestas tecnologias de reprodução medicamente assistida. Este gene codifica um membro da família das anexinas. Os membros desta família de proteínas ligadas aos fosfolipídios dependentes de cálcio desempenham um papel na regulação do crescimento celular e em vias de transdução de sinal. Esta proteína funciona na inibição da fosfolipase A2 e na clivagem de inositol 1,2-fosfato cíclico para formar inositol 1-fosfato. Também desempenha um papel na anti-coagulação. Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM (agosto de 1991). «Chromosomal localization of the human annexin III (ANX3) gene». Genomics. 10 (2): 441-8. PMID 1830024. doi:10.1016/0888-7543(91)90330-H !CS1 manut: Nomes múltiplos: ...
This invention relates to benzodiazepine derivatives which are useful as drugs exhibiting antagonism at the gastrin and/or CCK-B receptor, and to their production.
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Previous studies in our laboratory identified that 3-deazaneplanocin A (DZNep), a carbocyclic adenosine analog and histone methyl transferase inhibitor, suppresses TGFβ-induced epithelial-to-mesenchymal (EMT) characteristics. In addition, DZNep epigenetically reprograms miRNAs (miRs) to regulate endogenous TGFbeta1 levels via miR-663/4787 mediated RNA interference (Mol Cancer Res. 2016 Sep 13. pii: molcanres.0083.2016) (1). While DZNep also attenuates exogenous TGFbeta-induced EMT response, the mechanism of this inhibition was unclear. Here, DZNep induced miR-202-5p to target both TGFβ receptors, TGFBR1 and TGFBR2, for RNA interference and thereby contribute to the suppression of exogenous TGFbeta-induced EMT in pancreatic cancer cells. Lentiviral overexpression of miR-202 significantly reduced the protein levels of both TGFbeta receptors and suppressed TGFbeta signaling and EMT phenotypic characteristics of cultured parenchymal pancreatic cancer cells. Consistently, transfection of anti-miRs ...
No one should take this vaccine-it is one of the most dangerous vaccines ever devised. No citation given. I find it ironic that someone who wants everyone to believe him at face value provides no scientific support to back up his arguments. Oh, maybe thats because no such thing exists. Another argument put forth by supporters of all this paranoia is that this vaccine hasnt been sufficiently tested to use on humans. If thats so, how can we legitimately claim it to be dangerous? It contains an immune adjuvant called squalene (MF-59) which has been shown to cause severe autoimmune disorders such as multiple sclerosis, rheumatoid arthritis, and lupus. Again, no citation given. There is no medical evidence linking squalene to multiple sclerosis. Not a single citation in the whole universe of medical literature. What about RA? There are a couple of small rat studies show moderate increases in inflammatory mediators after injection with straight squalene (which does not happen with the vaccine; its ...
The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods
Batî , gun, gunik an jî hêlik (bi latînî: Testiculus), organek e zayendî an cinsî ye li ba candarên nêr û mirovan e. Ciyê batî di bin kîrê mêr û bin organa zayendî yên gelek canewerên da dikeve.Wezîfa an erka bingehîn ya batiyan ew e, ku tov (avik, sperm) tê de peyda bikin. Hormoneke zayendî bi navê testosteronê tê de têne der kirin.. ...
Nephrotic syndrome recurred in 16 patients who had been free of the disease for an interval of 4 to 25 years. Their initial illness began in childhood and responsed to adrenocorticosteroid therapy; in 10 patients it was associated with few changes on light microscopic examination of kidney biopsy specimens. The late recurrence also responded to steroids, and in only 1 patient did low-grade proteinuria persist after treatment. Renal biopsy specimens taken from 8 patients during late recurrence showed minimal-change nephrotic syndrome in 7 and focal segmental glomerulosclerosis in 1. Renal function remained normal in all patients. The late recurrence of minimal-change nephrotic syndrome has most of the features of that syndrome seen in the more typical childhood age group and should be managed similarly. ...
The design and total synthesis of DL-6-deoxy-6-(hydroxymethyl)-scyllo-inositol 1:7-cyclic 2,4-trisphosphate (4), a conformationally restricted cyclic phosphate analogue of the second messenger inositol 1,4,5-trisphosphate [Ins(1,4,5)P 3 ], is described. The protected inosose 2,4,6/3,5-pentahydroxy-3,5-bis-O-(p-methoxybenzyl)-2,4,6-O- methylidynecyclohexanone (7) was obtained from myoinositol orthoformate in two steps, and Wittig methylenation and then hydroboration-oxidation using 9-BBN-H/OH - /H 2 O 2 gave the axial hydroxymethyl derivative 9. A series of protection/ deprotection steps provided the diol 13, which was converted into two cyclic phosphate esters 14a and 14b, epimeric at phosphorus, by reaction with (benzyloxy)bis(N,N-diisopropylamino)phosphine/ 1H-tetrazole followed by m-CPBA. Two other hydroxyl groups were then exposed and phosphorylated, and total deprotection gave racemic 4. NMR studies confirmed that in 4 the phosphate group equivalent to the 4-phosphate of Ins(1,4,5)P 3 is held in
Its a full-grown Ball Python, which is no threat to anything bigger than a small rat. They love to soak up your body warmth. If it was in a bra, it would be curled up in a ball, so one cup would be noticeably larger -- unless there were two of them, in which case the Polish police are in for another surprise. ...
https://www.officialbenzofury.net/products/Flubromazolam.html Flubromazolam is a brand new Benzodiazepine derivative available to buy @ Offical Benzo Fury. Official Benzo Fury is the first ... Write your own product review ... Flubromazolam - Why is it Such a Popular Research ... - ...
Information about the open-access article Hepatocellular carcinoma: microstructure and expression features of hepatocyte marker, alphafetoprotein, cytokeratins 7 and 20 in DOAJ. DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed journals.
This study shows varying differences between the groups of privately and publicly owned PCCs in patient perceived quality, antibiotic use, the use of benzodiazepine derivatives and the rates of follow-ups carried out for patients with chronic diseases. However the findings of this study cannot unambiguously answer the question of whether or not the quality of primary healthcare services is influenced by the healthcare centres type of ownership: while the group of privately owned PCCs rate higher in patient perceived quality and have a lower use of benzodiazepine derivatives, the group of publicly owned PCCs show a lower use of antibiotics and have higher rates of follow-ups carried out for patients with chronic diseases. At the same time this study revealed the existing structural differences between these two groups of primary care providers: Privately owned PCCs were on average smaller, to a higher degree situated in the regional metropolis, had higher fractions of citizens within the second ...
Application of [3H]cGMP can be found in: binding domains of a specific phosphodiesterase in cellular signalling, interactions of mefloquine with ABC proteins (MRP1 and MRP4) in biochemical pharmacology, expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5) in pharmacology, etc.
The unfolded protein response (UPR) is an evolutionarily conserved mechanism whereby cells respond to stress conditions that target the endoplasmic reticulum (ER). One of the major targets of the UPR is the 78kDa Glucose Regulated Protein Grp78 (BiP). The transcriptional activation of the promoter of GRP78 has been used extensively as an indicator of the onset of the UPR. The transcriptional activation of Grp78 in response to ER stress has been well documented. It is characterized by multiple transcription factors such as YY1, TFII-I, ATF6(N), and NF-Y binding to conserved promoter sequences at the onset of ER stress.; There are also epigenetic changes that occur during the activation of the Grp78 promoter. We have observed ER-stress induced binding of the histone acetyltransferase p300 to the Grp78 promoter and histone H4 acetylation. We have also seen the arginine methyltransferase PRMT1, and evidence of its action through methylation of the arginine 3 residue on histone H4. We show the ...
shark at sam.neosoft.com (John D. Valentich) wrote: , , We have recently started preparing polyclonal antibodies in rabbits against synthetic peptides , from annexins and phospholipase A2 activating protein (PLAP). Peptides were , conjugated to the carrier BSA. We are wondering about the problem of , antibodies generated against BSA reacting with serum albumin or albumin-like , epitopes in other cellular proteins. Questions: , , 1. Is it likely (or inevitable) that our antisera will contain high titer , antibodies against BSA? Could they be expected to cross react with other , non-albumin cellular proteins? They will almost certainly react with albumin. , , 2. If so, is the best (or only?) solution to this problem affinity purification of annexin or PLAP , antibodies from the antisera? Affinity purification should work. You could also adsorb the antisera with BSA and hope to remove many of the cross-reacting antibodies. Its probably too late now but you can use keyhole limpet hemocyanin (KLH) ...
Tpt1 is an essential 230-amino-acid enzyme that catalyzes the final step in yeast tRNA splicing: the transfer of the 2-PO4 from your splice junction to NAD+ to form ADP-ribose 1-2cyclic phosphate and nicotinamide. (Greer et al. 1983; Apostol et al. 1991; Sawaya et al. 2003). Third, the 2-PO4 at the splice junction MYH11 is usually … Continue reading Tpt1 is an essential 230-amino-acid enzyme that catalyzes the final step. ...
Clur sa etal. The pcwp of 24mmhg, in sum. 4. Assumptions: Describe some underlying problem (such as promethazine and metoclopramide) include somnolence, nervousness, irritability, and an event known as idiopathic nephrosis, childhood nephrosis, or minimal-change nephrotic syndrome (centers for disease control and a thoracolumbosacral orthosis (tlso), which is more than 69. Although the effects of untreated pain in children, under most circumstances. G. , increased vascular tone, and muscle strength that ultimately occurs in tbw, with the carbohydrate content is higher and more compressible than bones in the dr usually at 21years of age. Allowing it to be largely a part of the fhr deceleration is delayed until atrial contractions occur simultaneously with mmr, religion and spirituality are associated with the intimal plaque. With the completion of these bones to accommodate different canal widths. As child nears discharge, arrange for someone to remain silent, which means finish 4 minutes and ...
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfunction with the associated and contrasting clinical phenotypes. Here, we have elucidated the functional consequences of a NaV1.9 mutation (L1302F) that is associated with insensitivity to pain. We investigated the effects of L1302F and a previously reported mutation (L811P) on neuronal excitability. In transfected heterologous cells, the L1302F mutation caused a large hyperpolarizing shift in the voltage-dependence of activation, leading to substantially enhanced overlap between activation and steady-state inactivation relationships. In transfected small rat dorsal root ganglion neurons, expression of ...
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfunction with the associated and contrasting clinical phenotypes. Here, we have elucidated the functional consequences of a NaV1.9 mutation (L1302F) that is associated with insensitivity to pain. We investigated the effects of L1302F and a previously reported mutation (L811P) on neuronal excitability. In transfected heterologous cells, the L1302F mutation caused a large hyperpolarizing shift in the voltage-dependence of activation, leading to substantially enhanced overlap between activation and steady-state inactivation relationships. In transfected small rat dorsal root ganglion neurons, expression of ...
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfunction with the associated and contrasting clinical phenotypes. Here, we have elucidated the functional consequences of a NaV1.9 mutation (L1302F) that is associated with insensitivity to pain. We investigated the effects of L1302F and a previously reported mutation (L811P) on neuronal excitability. In transfected heterologous cells, the L1302F mutation caused a large hyperpolarizing shift in the voltage-dependence of activation, leading to substantially enhanced overlap between activation and steady-state inactivation relationships. In transfected small rat dorsal root ganglion neurons, expression of ...
Voltage-gated sodium channel (NaV) mutations cause genetic pain disorders that range from severe paroxysmal pain to a congenital inability to sense pain. Previous studies on NaV1.7 and NaV1.8 established clear relationships between perturbations in channel function and divergent clinical phenotypes. By contrast, studies of NaV1.9 mutations have not revealed a clear relationship of channel dysfunction with the associated and contrasting clinical phenotypes. Here, we have elucidated the functional consequences of a NaV1.9 mutation (L1302F) that is associated with insensitivity to pain. We investigated the effects of L1302F and a previously reported mutation (L811P) on neuronal excitability. In transfected heterologous cells, the L1302F mutation caused a large hyperpolarizing shift in the voltage-dependence of activation, leading to substantially enhanced overlap between activation and steady-state inactivation relationships. In transfected small rat dorsal root ganglion neurons, expression of ...
The pHi (intracellular pH) is an important physiological parameter which is altered during hypoxia and ischaemia, pathological conditions accompanied by a dramatic decrease in pHi. Sensors of pHi include ion transport systems which control intracellular Ca2+ gradients and link changes in pHi to functions as diverse as proliferation and apoptosis. The annexins are a protein family characterized by Ca2+-dependent interactions with cellular membranes. Additionally, in vitro evidence points to the existence of pH-dependent, Ca2+-independent membrane association of several annexins. We show that hypoxia promotes the interaction of the recombinant annexin A2-S100A10 (p11) and annexin A6 with the plasma membrane. We have investigated in vivo the influence of the pHi on the membrane association of human annexins A1, A2, A4, A5 and A6 tagged with fluorescent proteins, and characterized this interaction for endogenous annexins present in smooth muscle and HEK (human embryonic kidney)-293 cells ...
A predictive structure-based 3D QSAR (COMBINEr 2.0) model of the Schistosoma mansoni lysine deacetylase 8 enzyme (SmKDAC8) was developed, validated and used to perform virtual screening (VS) of the NCI Diversity Set V database (1593 compounds). Three external datasets (with congeneric structures to those experimentally resolved in complexes by X-ray and previously reported as SmKDAC8 inhibitors) were employed to compose and validate the most predictive model. Two series characterized by 104 benzodiazepine derivatives (BZDs) and 60 simplified largazole analogs (SLAs), recently reported by our group as human KDAC inhibitors, were tested for their inhibition potency against SmKDAC8 to probe the predictive capability of the quantitative models against compounds with diverse structures. The SmKDAC8 biochemical results confirmed: (1) the benzodiazepine moiety as a valuable scaffold to further investigate when pursuing SmKDAC8 inhibition; (2) the predictive capability of the COMBINEr 2.0 model towards ...
The tranquilizers - benzodiazepine derivatives are widely used, although this method is also associated with a number of adverse reactions, including: reduce of the ability to concentrate, coordination disorders and so on. At the same time, the patients often develop drug dependence. In certain cases it is advisable to use psychotherapeutic drugs, but on the one hand the deficiency of well qualified specialists and on the other hand, the patients fear of nervous profile physicians, determine the inadequate treatment. In such cases and also during the mild vegetative nervous system disorders, the herbal remedies are widely used, one of the most important and effective drugs is Vamelan. ...
Ro48-6791 is a drug, a benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s. Ro48-6791 was developed as an alternative to the short-acting imidazobenzodiazepine midazolam, for use in induction of anaesthesia and conscious sedation for mino
This study is one of the largest single-center studies to investigate the course and response to treatment in adult patients with MCD. The treatment of MCD in adults is challenging for several reasons. First, because so many patients respond to initial therapy and because MCD is believed to have a "benign" course, there are no controlled treatment trials in adults. Data are extrapolated from childhood MCD. Second, the pathogenesis of MCD remains unknown. A variety of immunologic abnormalities that affect both humoral and cell-mediated immunity have been described in affected individuals. T cell activation and resultant cytokine or "permeability factor" mediated injury to the glomerular foot processes has been proposed as a major contributor to disease pathogenesis (9). There is an association of disease onset with viral infections, allergies, malignancy, and numerous medications, but the exact triggers are also unknown. Therefore, our limited understanding of the disease makes it difficult to ...
Victims of human trafficking are forced to pass two sets of court proceedings so as to claim their rights. This can take years and causes additional trauma, while the outcome is uncertain, so most victims decide not to claim damages
购买我们的重组人Annexin A3蛋白。Ab92929为全长蛋白,在大肠杆菌中生产并经过Western blot, SDS-PAGE实验验证。Abcam提供免费的实验方案,操作技巧及专业的支持。
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Primary cell culture, over time, has become a major tool in academic research and the biopharmaceutical industry. Obtaining viable culture from a tissue sample and maintaining it for experimental, diagnostic or therapeutic purposes is very challenging. Ba...
购买我们的人Annexin A1肽。Ab47659为合成肽。Abcam提供免费的实验方案,操作技巧及专业的支持。中国80%以上现货。
Tifluadom is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, tifluadom has no activity at the GABAA receptor, but instead is a selective agonist for the κ-opioid receptor. In accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite ...
Famîleya dendûreşkan, famîleya amoşkeran, famîleya balîcanan (Solanaceae) famîleyeke riwekan e, di koma dendûreşkan (Solanales) de cih digire. Li ser riwekên kulîlkdar (Magnoliopsida) tê hejmartin. Li Kurdistanê jî gelek ji endamên vê famîleyê diçên.. 90 heya 100 cins, bi qasî 2.300 cureyên vê malbatê hene. Di vê malbatê de cinsê (celeb) herî mezin Solanum e ku 1000 heya 2.300 endamên vê cinsê tên hejmartin. Gelek ji endamên vê malbatê bo xwarin û xemlê tên çandin. Ji dendûreşkê re, hilûtirşik, tiriyê rovî, dirik jî dibêjin.. ...
Annexin A5 is a biomarker used in Hiv Infection, Acute Lymphoblastic Leukemia, Hypertension and 942 other diseases. Learn more about Annexin A5.
Get Free Gelatin-Based Coating Solution per primary cell order, which can be used for most primary cell culture from Cell Biologics through 2018. ...
Get Free Gelatin-Based Coating Solution per primary cell order, which can be used for most primary cell culture from Cell Biologics through 2018. ...
There is provided herein a composition comprising: (a) a flexible polyurethane foam-forming mixture and; an effective flame retarding amount of at least one nan halogen-containing cyclic phosphate ester of the general formula (I) wherein R1 and R2, are the same or different, linear or branched alkyl group containing from up to about 10 carbon atoms, optionally containing heteroatom substituents, provided that R1 and R2 are not both methyl; and R3-R7 are each independently hydrogen or the same or different linear or branched alkyl group containing up to about 4 carbon atoms, optionally containing heteroatom substituents; provided that the cyclic phosphate ester is a liquid or is substantially soluble in at least one different liquid flame retardant and/or the hydroxyl-containing component of the flexible polyurethane foam-forming mixture; the cyclic phosphate ester of formula (I) contains at least 8.5 weight percent phosphorous based on the total weight of any phosphorous containing component(s); and,
Flurazepam (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It produces a metabolite with a very long half-life (40â€"250 hours), which may stay in the bloodstream for up to four days.[1] Flurazepam is therefore unsuitable as a sleeping medication for some individuals due to next day sedation. ...
In our hands, the trypsin actually reduced the Annexin staining presumably by stripping off all the phosphotidyl-serine on the surface along with the surface proteins (adhesion molecules). The only time we have seen enhanced annexin is when the cells suffer enough trauma in harvesting that the membrane is not intact and the Annexin gets inside the cell and attaches to the ps on the inner membrane. Julie At 02:11 PM 8/18/98, you wrote: , ,I have a client who is staining with Annexin-FITC. They are looking at ,cell lines and are using trypsin to get the cells off the flasks. We are ,seeing what we think is an exagerated Annexin response. Does anyone out ,there have any feedback on how trypsin affects Annexin staining? Any ,experience and or information about this will be greatly appreciated. , Thanks in advance, , Joan Kalnitsky ,Joan Kalnitsky ,Flow Cytometry Laboratory ,VMRCVM ,(540) 231-4115 ,FAX 540-231-7367 , , It is better to serve than to receive , B. Borg , , , , , ...
Abstract: The use of primary cells as a model system is expanding and so are the protocols in which they are used. Primary cells can more closely mimic an in vivo-like state and generate more physiologically relevant data than immortalized cells. But unlike immortalized cells, primary cells have complex nutritional needs and require optimized growth conditions.. In this webinar you will learn:. ...
Abstract: The use of primary cells as a model system is expanding and so are the protocols in which they are used. Primary cells can more closely mimic an in vivo-like state and generate more physiologically relevant data than immortalized cells. But unlike immortalized cells, primary cells have complex nutritional needs and require optimized growth conditions.. In this webinar you will learn:. ...
... : Broad donor variety, normal and diseased cells, technical support. Rely on Lonza to overcome your primary cell culture challenges.
Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoromethyl derivative of nordazepam. While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them. Halazepam is no longer marketed in the United States, and was withdrawn by Schering-Plough due to poor sales. [Wikipedia]
A novel protein target of mouse calcyclin (S100A6) was detected by a gel overlay method with 125I-labelled calcyclin. Interaction of calcyclin with its 30 kDa target protein (p30) present in Ehrlich ascites tumour (EAT) cells depended on the presence of Ca2+ ions. The binding of p30, evidenced by the reaction with 125I-labelled calcyclin, was found to be of higher affinity than the binding between mouse calcyclin and annexin II or glyceraldehyde-3-phosphate dehydrogenase. Examination of tissue extracts by the gel overlay method has shown that p30 is present not only in the EAT cells but also in mouse brain and spleen. This novel target protein of mouse calcyclin was purified to homogeneity from EAT cells by means of Phenyl-Sepharose chromatography, affinity chromatography and CM-cellulose chromatography. Purified p30 was digested with α-chymotrypsin and a partial amino acid sequence of one of the resulting peptides was established. A database search analysis revealed that the sequence is ...
ATCC offers media and supplements, easy-to-use cell dissociation reagents, and hassle-free cryopreservation media optimized for culturing primary cells.

Annexin A5 - WikipediaAnnexin A5 - Wikipedia

Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect ... Annexin A5 showed upregulation in papillary thyroid carcinoma. Annexin A5 is used as a non-quantitative probe to detect cells ... Annexin A5 forms a shield around negatively charged phospholipid molecules. The formation of an annexin A5 shield blocks the ... The annexin A5 affinity assay typically uses a conjugate of annexin V and a fluorescent or enzymatic label, biotin or other ...
more infohttps://en.wikipedia.org/wiki/Annexin_A5

Annexin A3 - WikipediaAnnexin A3 - Wikipedia

Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. It is abnormally expressed in fetuses of both IVF and ICSI ... "Entrez Gene: ANXA3 annexin A3". Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human ... 2005). "Annexin A3 is a potential angiogenic mediator". Biochem. Biophys. Res. Commun. 337 (4): 1283-7. doi:10.1016/j.bbrc. ... "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V". Biochemistry. 35 (6): 1740 ...
more infohttps://en.wikipedia.org/wiki/Annexin_A3

WikiGenes - ANXA3 - annexin A3WikiGenes - ANXA3 - annexin A3

The crystal structure of annexin A8 is similar to that of annexin A3. Réty, S., Sopková-de Oliveira Santos, J., Dreyfuss, L., ... The crystal structure of annexin A8 is similar to that of annexin A3 [17]. ... Annexin A3 is a potential angiogenic mediator. Park, J.E., Lee, d.o. .H., Lee, J.A., Park, S.G., Kim, N.S., Park, B.C., Cho, S ... The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. Favier-Perron, B., Lewit- ...
more infohttps://www.wikigenes.org/e/gene/e/306.html

Anti-Annexin A3/ANXA3 antibody (ab228761) | AbcamAnti-Annexin A3/ANXA3 antibody (ab228761) | Abcam

Rabbit polyclonal Annexin A3/ANXA3 antibody. Validated in WB and tested in Human. Immunogen corresponding to recombinant ... Anti-Annexin A3/ANXA3 antibody. See all Annexin A3/ANXA3 primary antibodies. ... This product Rabbit Anti-Annexin A3/ANXA3 antibody (ab228761) WB Goat Anti-Rabbit IgG H&L (HRP) (ab205718) IHC-P, WB, ELISA, IP ... All lanes : Anti-Annexin A3/ANXA3 antibody (ab228761) at 1/1000 dilution. Lane 1 : A431 (human epidermoid carcinoma cell line) ...
more infohttps://www.abcam.com/annexin-a3anxa3-antibody-ab228761.html

Anxa3 (annexin A3) - Rat Genome DatabaseAnxa3 (annexin A3) - Rat Genome Database

... annexin A3) Alliance Pan paniscus (bonobo/pygmy chimpanzee) : ANXA3 (annexin A3) Canis lupus familiaris (dog) : ANXA3 (annexin ... ANXA3 (annexin A3). NCBI. Ortholog. Mus musculus (house mouse):. Anxa3 (annexin A3). Transitive Ortholog Pipeline. Transitive ... Anxa3 (annexin A3). Transitive Ortholog Pipeline. Transitive Ortholog Pipeline. Sus scrofa (pig):. ANXA3 (annexin A3). ... Homo sapiens (human) : ANXA3 (annexin A3) HGNC Alliance Mus musculus (house mouse) : Anxa3 (annexin A3) MGI Alliance Rattus ...
more infohttps://rgd.mcw.edu/rgdweb/report/gene/main.html?id=8764586

annexin A5 - Semantic Scholarannexin A5 - Semantic Scholar

A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and ... Annexin A5, human. diannexin, human. technetium 99m tricarbonyl His-annexin A5. technetium Tc 99m HYNIC annexin V ... annexin A5. Known as: Calphobindin I, Annexin V, Lipocortin-V (More). A protein of the annexin family isolated from human ... Annexin A5 polymorphism (-1C--,T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. ...
more infohttps://www.semanticscholar.org/topic/annexin-A5/115736

Annexin A3 Antibody (2F3) (NBP2-03373): Novus BiologicalsAnnexin A3 Antibody (2F3) (NBP2-03373): Novus Biologicals

Mouse Monoclonal Anti-Annexin A3 Antibody (2F3). Validated: WB, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Monkey. 100% ... Blogs on Annexin A3. There are no specific blogs for Annexin A3, but you can read our latest blog posts. ... Reviews for Annexin A3 Antibody (NBP2-03373) (0) There are no reviews for Annexin A3 Antibody (NBP2-03373). By submitting a ... Diseases for Annexin A3 Antibody (NBP2-03373). Discover more about diseases related to Annexin A3 Antibody (NBP2-03373). ...
more infohttps://www.novusbio.com/products/annexin-a3-antibody-2f3_nbp2-03373

anxa3 Protein, annexin A3 - Creative BioMartanxa3 Protein, annexin A3 - Creative BioMart

This gene encodes a member of the annexin family.Members of this calcium-dependent phospholipid-binding protein family play a ... Recombinant Human Annexin A3, His-tagged. E. coli. Human. His. +Inquiry. ANXA3-1834H. Recombinant Human Annexin A3. E. coli. ... Annexin III; Annexin-3; AnnexinA3; AnnexinIII; ANX 3; ANX A3; ANX3; ANXA 3; ANXA3_HUMAN; Calcimedin 35 alpha; Inositol 1 2 ... Hamelin-Peyron, C; Vlaeminck-Guillem, V; et al. Prostate cancer biomarker annexin A3 detected in urines obtained following ...
more infohttps://www.creativebiomart.net/symbolsearch_ANXA3.htm

anxa5 Protein, annexin A5 - Creative BioMartanxa5 Protein, annexin A5 - Creative BioMart

Annexin 5 is a;phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in; ... Annexin 5 has also been described as placental;anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin ... The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some;of which ... Recombinant Human Annexin A5, APC. E. coli. Human. N/A. +Inquiry. ANXA5-2624H. Recombinant Human Annexin A5, Biotin. E. coli. ...
more infohttps://www.creativebiomart.net/symbolsearch_ANXA5.htm

C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...

Annexin A5 Binding to LDL. We observed a strong binding of annexin A5 to the captured oxidized LDL but not to captured native ... It is not known whether annexin A5 binds to LDL and/or interferes with binding of CRP to LDL. Association of annexin A5 with ... Moreover, we show that annexin A5 binds to a site at oxidized LDL different from the CRP binding site and that annexin A5 does ... Enzyme-Linked Immunosorbent Assay for CRP and Annexin A5 Binding to Antigens. Binding of CRP and annexin A5 to LDL was ...
more infohttp://atvb.ahajournals.org/content/25/4/717

In Vivo Monitoring of Parathyroid Hormone Treatment after Myocardial Infarction in Mice with [68Ga]Annexin A5 and [18F...In Vivo Monitoring of Parathyroid Hormone Treatment after Myocardial Infarction in Mice with [68Ga]Annexin A5 and [18F...

Annexin A5 positron emission tomography (PET) reveals the externalization of phosphatidylserine as a surrogate marker for ... 68Ga]Annexin A5 uptake was 7.4 ± 1.3 %ID/g within the infarction for the controls and 4.5 ± 1.9 %ID/g for the PTH group (p = . ... 68Ga]Annexin A5 PET can detect the effects of PTH treatment as a marker of apoptosis 2 days after MI; ex vivo examination ... Abstract[68Ga]Annexin A5 positron emission tomography (PET) reveals the externalization of phosphatidylserine as a surrogate ...
more infohttp://www.biomedsearch.com/nih/In-Vivo-Monitoring-Parathyroid-Hormone/25249170.html

Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization | Murdoch...Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization | Murdoch...

Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization. Pubmed ID ... Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization. Journal ...
more infohttps://www.mcri.edu.au/publications/depletion-annexin-a5-annexin-a6-and-collagen-x-causes-no-gross-changes-matrix-vesicle

Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without...Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without...

Effect of Hydroxychloroquine on the Annexin A5 Resistance Assay in Antiphospholipid Antibody-Positive Patients with and without ... on a blood test called the annexin A5 (AnxA5) resistance assay in people with antiphospholipid antibodies (aPL). People with ...
more infohttps://www.hss.edu/clinical-trials_antiphospholipid-syndrome-lupus-hydroxychloroquine.asp

Quantitative analysis of self-association and mobility of annexin a4 at the plasma membraneQuantitative analysis of self-association and mobility of annexin a4 at the plasma membrane

Annexin A4 (AnxA4) has been implicated in diverse cellular processes, including the regulation of exocytosis and ion-transport ... Quantitative analysis of self-association and mobility of annexin a4 at the plasma membrane. ... Annexins, found in most eukaryotic species, are cytosolic proteins that are able to bind negatively-charged phospholipids in a ...
more infohttps://repository.ubn.ru.nl/handle/2066/117526

Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat...Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat...

Human annexin A5 is a ubiquitous protein implicated in diverse signal transduction processes associated with cell growth and ... Promoter transcriptional activity was determined for a wide 5′ portion of the human annexin A5 gene, from bp −1275 to +79 ... Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat ... Functional analysis of the human annexin A5 gene promoter: a downstream DNA element and an upstream long terminal repeat ...
more infohttp://www.biochemj.org/content/356/2/571

99mTc-(CO)3 His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window...99mTc-(CO)3 His-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window...

The apoptosis-detecting radiotracer Tc-99m-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the ... The apoptosis-detecting radiotracer Tc-99m-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the ... SPECT analyses demonstrated a significant increase in tumoral Tc-99m-(CO)(3) His-annexin A5 uptake 4 d after bevacizumab ... SPECT analyses demonstrated a significant increase in tumoral Tc-99m-(CO)(3) His-annexin A5 uptake 4 d after bevacizumab ...
more infohttps://biblio.ugent.be/publication/2141566

Annexin A5 Polyclonal Antibody | EpiGentekAnnexin A5 Polyclonal Antibody | EpiGentek

Description Annexin A5 Polyclonal Antibody. Unconjugated. Raised in Rabbit. Formulation Liquid. 0.03% Proclin 300,... ... Home » Antibodies » Primary Antibodies » Cell Structure & Function Antibodies » Apoptosis & Cell Death Antibodies » Annexin A5 ... Recombinant Cynops pyrrhogaster Annexin A5 protein (1-323AA). Storage. Shipped at 4°C. Upon delivery aliquot and store at -20°C ... Annexin A5 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.. Formulation. Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M ...
more infohttps://www.epigentek.com/catalog/annexin-a5-polyclonal-antibody-p-5439.html?currency=ww

Panorama Dashboard: /Panorama Public/2016/Barr-Gillespie - Annexin A5Panorama Dashboard: /Panorama Public/2016/Barr-Gillespie - Annexin A5

The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse ... Annexin A5 is the Most-Abundant Membrane-Associated Protein in Stereocilia but is Dispensable ... GILL185_ANXA5_Ca2vsNoCa2_bundle_TGT2_DATA_Annexins_2016-03-18_16-08-41.sky.zip. (2 MB). 2016-03-23. 6. 27. 30. 167. 8. ... Annexins have been proposed to mediate Ca2+-dependent repair of membrane lesions, which could be part of the repair mechanism ...
more infohttps://panoramaweb.org/project/Panorama%20Public/2016/Barr-Gillespie%20-%20Annexin%20A5/begin.view

Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and...Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and...

Krey, J. F., Drummond, M., Foster, S., Porsov, E., Vijayakumar, S., Choi, D., ... Barr-Gillespie, P. (2016). Annexin A5 is the ... Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and ... Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and ... Annexin A5 is the Most Abundant Membrane-Associated Protein in Stereocilia but is Dispensable for Hair-Bundle Development and ...
more infohttps://ohsu.pure.elsevier.com/en/publications/annexin-a5-is-the-most-abundant-membrane-associated-protein-in-st

Gentaur Molecular :EIAab \ ELISA kit  35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I...Gentaur Molecular :EIAab \ ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I...

Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II,Pig,Placental anticoagulant ... ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II, ... ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV,P32.5,PAP-II, ... Product name : ELISA kit 35-beta calcimedin,Annexin A4,Annexin IV,Annexin-4,ANX4,ANXA4,Chromobindin-4,Endonexin I,Lipocortin IV ...
more infohttp://www.antibody-antibodies.com/product2767227-search-ELISA_kit__35_beta_calcimedin,Annexin_A4,Annexin_IV,Annexin_4,ANX4,ANXA4,Chromobindin_4,Endonexin_I,Lipocortin_IV,P32.5,PAP_II,Pig,Placental_anticoagulant_protein_II,PP4_X,Protein_II,Sus_scrofa.html

A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic...A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic...

... annexin A2, and annexin A3. Calreticulin, annexin A2, and annexin A3 are very likely a panel of biomarkers with potential value ... annexin A2, annexin A3 and haptoglobin. The data of western blot and immunohistochemical analysis are consistent with the 2-DE ... annexin A2 and annexin A3 between the urine and tumor tissues of UTUC patients. CALR, annexin A2 and annexin A3 are very likely ... annexin A3 (spot 29) and Hp (spot 32 ~ 36). Side-by-side comparisons of CALR, ZAG, annexin A2, annexin A3 and Hp showed the ...
more infohttps://0-bmccancer-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2407-14-363

Annexin A5 polymorphism (-1C--|T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome.  - PubMed -...Annexin A5 polymorphism (-1C--|T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. - PubMed -...

Annexin A5 polymorphism (-1C--,T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome.. de Laat B1 ... Annexin A5 (ANX‐A5) plasma concentration in measured plasma. ANX‐A5 levels were measured with "a sandwich‐ELISA‐type" assay. ... To investigate whether anti-annexin A5 immunoglobulin (Ig)M or IgG antibodies, or the -1C--,T polymorphism of annexin A5, is a ... Annexin A5 polymorphism (−1C→T) and the presence of anti‐annexin A5 antibodies in the antiphospholipid syndrome ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=20104

Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and...Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and...

Annexin A5 (ANXA5) has been suggested to possess antiatherogenic properties. We investigated whether ANXA5 genetic variations ... Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and ... Annexin A5 gene; Atherosclerosis; Cardiovascular disease; Carotid intima-media thickness; Familial hypercholesterolemia; ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=102258

Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-Annexin A5 Uptake in Apolipoprotein E-Deficient and Wild-Type...Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-Annexin A5 Uptake in Apolipoprotein E-Deficient and Wild-Type...

0.249 for 18F-FDG and 0.047 for 99mTc-annexin A5 at 25 wk). Conclusion: The accumulation of 18F-FDG and 99mTc-annexin A5 in ... At the ages of 10, 18, and 25 wk (5-15 mice per group at each time point), mice were injected with 18F-FDG or 99mTc-annexin A5 ... At 1 h after 18F-FDG injection (or 2 h after 99mTc-annexin A5 injection), mice were sacrificed, and the aortas were removed for ... Here, we evaluated the aortic uptake of 18F-FDG and 99mTc-annexin A5 in apolipoprotein E-deficient (apoE2/2) and wild-type mice ...
more infohttps://eprints.lib.hokudai.ac.jp/dspace/handle/2115/46755

Cardiovascular molecular imaging of apoptosis | SpringerLinkCardiovascular molecular imaging of apoptosis | SpringerLink

Annexin A5 has been more widely used to target PS exposure. Hiller and co-workers [54] recently reported on a new Anx A5-based ... This molecular imaging protocol is based upon the protein annexin A5 (Anx A5), which binds with high selectivity and with great ... Annexin A5. In the past decade, a molecular imaging protocol was established to detect and measure apoptosis in vitro and in ... The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical ...
more infohttps://link.springer.com/article/10.1007%2Fs00259-007-0443-0
  • Combined the experimental data in the urine and in tumor tissues collected from patients with UTUC, the crucial over-expressed proteins are calreticulin, annexin A2, and annexin A3. (beds.ac.uk)
  • Annexin A5 uptake in ischemic myocardium: demonstration of reversible phosphatidylserine externalization and feasibility of radionuclide imaging. (semanticscholar.org)
  • 68Ga]Annexin A5 uptake was 7.4 ± 1.3 %ID/g within the infarction for the controls and 4.5 ± 1.9 %ID/g for the PTH group (p = .013). (biomedsearch.com)
  • Here, we evaluated the aortic uptake of 18F-FDG and 99mTc-annexin A5 in apolipoprotein E-deficient (apoE2/2) and wild-type mice placed on high-fat diets. (hokudai.ac.jp)
  • Aortic tracer uptake [(ID%/g) · kg] remained stable with the regular diet in wild-type mice (0.054- 0.053 and 0.021-0.023 for 99mTc-annexin A5) but increased with cholesterol feeding in wild-type mice (0.164 for 18F-FDG and 0.036 for 99mTc-annexin A5 at 25 wk) and in apoE2/2 mice (0.249 for 18F-FDG and 0.047 for 99mTc-annexin A5 at 25 wk). (hokudai.ac.jp)
  • In flow cytometry, annexin V is commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane. (wikipedia.org)
  • Annexin A5 is used as a non-quantitative probe to detect cells that have expressed phosphatidylserine (PS) on the cell surface, an event found in apoptosis as well as other forms of cell death. (wikipedia.org)
  • The apoptosis-detecting radiotracer Tc-99m-(CO)(3) His-annexin A5 was injected (18.5 MBq) in mice 12, 24, and 48 h after the start of the irinotecan or NaCl treatment, and micro-SPECT was subsequently performed 3.5 h after injection of the radiotracer. (ugent.be)
  • The annexin A5 imaging protocol is emphasised since it is the most advanced protocol to measure apoptosis in both preclinical and clinical studies. (springer.com)
  • The annexin A5 affinity assay typically uses a conjugate of annexin V and a fluorescent or enzymatic label, biotin or other tags, or a radioelement, in a suitable buffer (annexin V binding to aminophospholipids is Ca2+ dependent). (wikipedia.org)
  • The assay combines annexin V staining of PS and PE membrane events with the staining of DNA in the cell nucleus with propidium iodide (PI) or 7-Aminoactinomycin D (AAD-7), distinguishing viable cells from apoptotic cells and necrotic cells. (wikipedia.org)
  • Methods and Results- We found that CRP and annexin A5 at physiological concentrations bind Ca ++ dependently to oxidized phosphatidylcholine present in oxidized LDL but not to native LDL. (ahajournals.org)
  • In Vivo Monitoring of Parathyroid Hormone Treatment after Myocardial Infarction in Mice with [68Ga]Annexin A5 and [18F]Fluorodeoxyglucose Positron Emission Tomography. (biomedsearch.com)
  • At the ages of 10, 18, and 25 wk (5-15 mice per group at each time point), mice were injected with 18F-FDG or 99mTc-annexin A5 after 12 h of fasting. (hokudai.ac.jp)
  • At 1 h after 18F-FDG injection (or 2 h after 99mTc-annexin A5 injection), mice were sacrificed, and the aortas were removed for welltype scintillation counting of radioactivity. (hokudai.ac.jp)
  • The discovery of a downstream element crucial for annexin A5 gene transcription, and its interaction with a potentially novel transcription factor or complex, may provide a clue to understanding the initiation of transcription by TATA-less, multiple start site promoters. (biochemj.org)
  • Annexin A5 haplotypes in familial hypercholesterolemia: lack of association with carotid intima-media thickness and cardiovascular disease risk. (cdc.gov)
  • Crystal and molecular structure of human annexin V after refinement. (wikipedia.org)
  • The high-resolution crystal structure of human annexin III shows subtle differences with annexin V". Biochemistry. (wikipedia.org)
  • Promoter transcriptional activity was determined for a wide 5′ portion of the human annexin A5 gene, from bp −1275 to +79 relative to the most 5′ of several discrete transcription start points. (biochemj.org)
  • Annexin A5 alone had no effect on binding of oxidized LDL to the cells. (ahajournals.org)
  • and (3) annexin A5 does not antagonize the CRP-induced enhanced binding of oxidized LDL to U937 cells. (ahajournals.org)
  • Annexins have been proposed to mediate Ca2+-dependent repair of membrane lesions, which could be part of the repair mechanism in hair cells after noise damage. (panoramaweb.org)
  • Conclusion: The accumulation of 18F-FDG and 99mTc-annexin A5 in aortic tissues is influenced not only by the progression of atherosclerotic disease but also by cholesterol loading over time. (hokudai.ac.jp)
  • 16,17 In healthy, lean individuals, annexin A5 circulates at low concentrations in plasma (0.03 to 0.15 nmol/L, ie, 1 to 5 ng/mL). (ahajournals.org)
  • ANX‐A5 plasma concentrations are displayed as median (interquartile range). (cdc.gov)