AnatomyChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Annexin A2Annexin A1Annexin A5Annexin A6Annexin A4Annexin A7Annexin A3AnnexinsS100 ProteinsPhosphatidylserinesApoptosisPropidiumCalciumPhospholipidsCalcium-Binding ProteinsCell MembraneProtein BindingCell Line, TumorCells, CulturedMolecular Sequence DataFlow CytometryAmino Acid SequenceCell-Derived MicroparticlesReceptors, Formyl PeptideRecombinant ProteinsCaspase 3Blotting, WesternOrganotechnetium CompoundsCell SurvivalCell LineCaspasesFluorescein-5-isothiocyanateIn Situ Nick-End LabelingFibrinolysinBinding Sites
Annexin A2
A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.
Annexin A1
Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.
Annexin A5
A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.
Annexin A6
Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.
Annexin A4
Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.
Annexin A7
An annexin family member that plays a role in MEMBRANE FUSION and signaling via VOLTAGE-DEPENDENT CALCIUM CHANNELS.
Annexin A3
A protein of the annexin family that catalyzes the conversion of 1-D-inositol 1,2-cyclic phosphate and water to 1-D-myo-inositol 1-phosphate.
Annexins
Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.
S100 Proteins
A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.
Phosphatidylserines
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Propidium
Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Phospholipids
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Calcium-Binding Proteins
Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.
Cell Membrane
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Protein Binding
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Cells, Cultured
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Cell-Derived Microparticles
Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.
Receptors, Formyl Peptide
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.
Recombinant Proteins
Proteins prepared by recombinant DNA technology.
Caspase 3
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Blotting, Western
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Organotechnetium Compounds
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
Cell Survival
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Cell Line
Established cell cultures that have the potential to propagate indefinitely.
Caspases
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Fluorescein-5-isothiocyanate
Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.
In Situ Nick-End Labeling
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
Fibrinolysin
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
Binding Sites
The parts of a macromolecule that directly participate in its specific combination with another molecule.

The Npc1 mutation causes an altered expression of caveolin-1, annexin II and protein kinases and phosphorylation of caveolin-1 and annexin II in murine livers. (1/431)

We have previously demonstrated (1) an increased expression of caveolin-1 in murine heterozygous and homozygous Niemann-Pick type C (NPC) livers, and (2) an increased concentration of unesterified cholesterol in a detergent insoluble caveolae-enriched fraction from homozygous livers. To define further the relationship between caveolin-1 function and the cholesterol trafficking defect in NPC, we examined the expression and distribution of additional caveolar and signal transduction proteins. The expression of annexin II was significantly increased in homozygous liver homogenates and the Triton X-100 insoluble floating fraction (TIFF). Phosphoamino acid analysis of caveolin-1 and annexin II from the homozygous TIFF demonstrated an increase in serine and tyrosine phosphorylation, respectively. To determine the basis for increased phosphorylation of these proteins, the expression and distribution of several protein kinases was examined. The expression of PKCalpha, PKCzeta and pp60-src (protein kinases) were significantly increased in both heterozygous and homozygous liver homogenates, while PKCdelta was increased only in homozygous livers. Of the protein kinases analyzed, only CK IIalpha was significantly enriched in the heterozygous TIFF. Finally, the concentration of diacylglycerol in the homozygous TIFF was significantly increased and this elevation may modulate PKC distribution and function. These results provide additional evidence for involvement of a caveolin-1 containing cellular fraction in the pathophysiology of NPC and also suggest that the Npc1 gene product may directly or indirectly, regulate the expression and distribution of signaling molecules.  (+info)

Tissue plasminogen activator and its receptor in the human amnion, chorion, and decidua at preterm and term. (2/431)

The plasminogen activator system consists of two proteins: tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which act upon their specific receptors to generate plasmin from plasminogen located on the cell surface. Plasmin then acts directly and indirectly to degrade the components of the extracellular matrix (ECM). This process is likely to be important in the normal turnover of the ECM of fetal membranes and in its premature weakening in preterm premature rupture of the fetal membranes. Quantitative Northern analysis and in situ hybridization have shown that the decidua expresses mRNA for tPA. However, the immunolocalized tPA protein was most strongly associated with the amnion and chorion, as was its receptor annexin II, suggesting that the amnion and chorion are the targets for decidual tPA. At term, decidual tPA expression was unaffected by labor, and the tPA receptor was elevated both before and after labor. At preterm, the converse was found: decidual tPA expression was significantly (p < 0. 05) up-regulated by labor, but the tPA receptor was not. The results suggest that the generation of plasmin at term would be controlled by an increased concentration of the tPA receptor in the amnion and chorion, whereas at preterm a pathological increase in plasmin would be generated by an overexpression of tPA, initiated by labor.  (+info)

Annexin II and bleeding in acute promyelocytic leukemia. (3/431)

BACKGROUND: Acute promyelocytic leukemia (APL) is associated with a hemorrhagic disorder of unknown cause that responds to treatment with all-trans-retinoic acid. METHODS: We studied a newly described receptor for fibrinolytic proteins, annexin II, in cells from patients with APL or other leukemias. We examined initial rates of in vitro generation of plasmin by tissue plasminogen activator (t-PA) in the presence of APL cells that did or did not have the characteristic translocation of APL, t(15;17). We also determined the effect of all-trans-retinoic acid on the expression of annexin II and the generation of cell-surface plasmin. RESULTS: The expression of annexin II, as detected by a fluorescein-tagged antibody, was greater on leukemic cells from patients with APL than on other types of leukemic cells (mean fluorescence intensity, 6.9 and 2.9, respectively; P<0.01). The t(15;17)-positive APL cells stimulated the generation of cell-surface, t-PA-dependent plasmin twice as efficiently as the t(15;17)-negative cells. This increase in plasmin was blocked by an anti-annexin II antibody and was induced by transfection of t(15;17)-negative cells with annexin II complementary DNA. The t(15;17)-positive APL cells contained abundant messenger RNA for annexin II, which disappeared through a transcriptional mechanism after treatment with all-trans-retinoic acid. CONCLUSIONS: Abnormally high levels of expression of annexin II on APL cells increase the production of plasmin, a fibrinolytic protein. Overexpression of annexin II may be a mechanism for the hemorrhagic complications of APL.  (+info)

Localization and quantitation of cardiac annexins II, V, and VI in hypertensive guinea pigs. (4/431)

Annexins are characterized by Ca2+-dependent binding to phospholipids. Annexin II mainly participates in cell-cell adhesion and signal transduction, whereas annexins V and VI also seem to regulate intracellular calcium cycling. Their abundance and localization were determined in left ventricle (LV) and right ventricle (RV) from hypertensive guinea pigs, during the transition from compensatory hypertrophy to heart failure. Immunoblot analysis of annexins II, V, and VI revealed an increased accumulation (2.6-, 1.45-, and 2.3-fold, respectively) in LV from hypertensive guinea pigs and no modification in RV. Immunofluorescent labeling of annexins II, V, and VI; of Na+-K+-ATPase; and of sarcomeric alpha-actinin showed that in control LV and RV, 1) annexin II is present in nonmuscle cells; 2) annexins V and VI are mainly observed in the sarcolemma and intercalated disks of myocytes; 3) annexins II, V, and VI strongly label endothelial cells and adventitia of coronary arteries; and 4) annexin VI is present in the media. At the onset of heart failure, the most striking changes are the increased protein accumulation in LV and the very strong labeling of annexins II, V, and VI in interstitial tissue, suggesting a role in fibrosis development and cardiac remodeling.  (+info)

The biological effects induced in mice by p36, a proteinaceous factor of virulence produced by African swine fever virus, are mediated by interleukin-4 and also to a lesser extent by interleukin-10. (5/431)

We have previously presented indirect evidence that both specific immunosuppression and lymphocyte mitogenicity induced in mice by p36, a proteinaceous factor of virulence produced by porcine monocytes infected by African swine fever virus, were consistent with a Th2-driven response. Here we show: (1) Interleukin-4 (IL-4) and interleukin-10 (IL-10) mRNA expression in the spleen and thymus of C57BL/6 mice were displayed early after p36 inoculation. The expression of thymic IL-10 mRNA occurred, however, later than that of IL-4 mRNA. (2) Increased serum levels of these two cytokines were also soon detected after the protein inoculation. (3) Both immunosuppressive and mitogenic effects of p36 were absent in IL-4 gene-targeted mice and partially abrogated in mice depleted of IL-4 by neutralizing monoclonal antibodies. (4) IL-10 depletion abrogated the immunosuppressive but not the p36 lymphocyte mitogenic biological effects. (5) The increase in the serum concentrations of both IL-4 and IL-10 were lower in thymectomized than in non-thymectomized mice. (6) The expression of interferon-gamma (IFN-gamma) mRNA was weakly or not at all induced in p36-treated mice. Taken together, these results are in agreement with the promotion of a Th2 immune response induced by p36.  (+info)

Dexamethasone alters arachidonate release from human epithelial cells by induction of p11 protein synthesis and inhibition of phospholipase A2 activity. (6/431)

The effect of the glucocorticosteroid, dexamethasone, on arachidonic acid (AA) release and on protein levels of p11 and cytosolic phospholipase A2 (cPLA2) was studied in two epithelial cell lines, HeLa cells and BEAS-2B cells. Dexamethasone treatment of HeLa cells and BEAS-2B cells increased cellular p11 protein and mRNA levels in a time- and dose-dependent manner. It had little effect on levels of cPLA2 protein. In order to determine if increased p11 protein expression resulted in increased interaction between p11 and cPLA2, anti-cPLA2 antibodies were used to immunoprecipitate p11.cPLA2 complexes and Western blots of the immunoprecipitate were used to detect p11. In cells treated with dexamethasone, more p11 was detected in the anti-cPLA2 immunoprecipitate compared with control cells. Dexamethasone treatment of HeLa cells prelabeled with [3H]AA decreased the release of [3H]AA under basal conditions and after stimulation with the calcium ionophore A23187 (10(-6) M). In order to determine if altering the p11 protein levels in HeLa cells independent of glucocorticosteroid treatment could also produce an effect on [3H]AA release, cells were stably transfected with plasmids expressing either p11 antisense mRNA or p11 mRNA. Cloned HeLa cells expressing p11 antisense mRNA exhibited less cellular p11 protein compared with control cells and greater [3H]AA release compared with cells transfected with a control vector. Cloned HeLa cells stably transfected with a p11 expression vector exhibited increased p11 cellular protein and diminished [3H]AA release under basal conditions and in response to A23187. Therefore, dexamethasone alteration of epithelial cell AA release may be due in part to induction of p11 protein expression.  (+info)

Annexin II increases osteoclast formation by stimulating the proliferation of osteoclast precursors in human marrow cultures. (7/431)

Annexin II (AXII), a calcium-dependent phospholipid-binding protein, has been recently found to be an osteoclast (OCL) stimulatory factor that is also secreted by OCLs. In vitro studies showed that AXII induced OCL formation and bone resorption. However, the mechanism of action by which AXII acts as a soluble extracellular protein to induce OCL formation is unknown. In this paper, we demonstrate that AXII gene expression is upregulated by 1,25-dihydroxyvitamin D3 [1, 25-(OH)2D3] and that addition of AXII significantly increased OCL-like multinucleated cell formation. Time-course studies suggested that AXII acted on the proliferative stage of OCL precursors and that AXII increased thymidine incorporation in OCL precursors. Moreover, AXII enhanced the growth of CFU-GM, the earliest identifiable OCL precursor, when bone marrow cultures were treated with low concentrations of GM-CSF. This capacity of AXII to induce OCL precursor proliferation was due to induction of GM-CSF expression, because the addition of neutralizing antibodies to GM-CSF blocked the stimulatory effect of AXII on OCL formation. RT-PCR analysis using RNA from highly purified subpopulations of marrow cells demonstrated that T cells, especially CD4(+) T cells, produced GM-CSF in response to AXII. Furthermore, FACS(R) analysis of T-cell subpopulations treated with fluorescein-labeled AXII suggested that the CD4(+), but not CD8(+), subpopulation of T cells express an AXII receptor. Taken together, these data suggest that AXII stimulates OCL formation by activating T cells through a putative receptor to secrete GM-CSF. GM-CSF then expands the OCL precursor pool to enhance OCL formation.  (+info)

Interference with annexin II has no effect on entry of human cytomegalovirus into fibroblast cells. (8/431)

Annexin II has been identified as a human cytomegalovirus (HCMV)-binding protein, shown to be a component of purified virions and proposed as a cellular receptor for the virus. In addition, annexin II is capable of associating with the major HCMV envelope glycoprotein, gB (gpUL55). As one approach to examine the role of annexin II in virus entry, a high-titre polyclonal annexin II-specific antibody was produced and its effects in virus entry and cell-to-cell spread assays were tested. This anti-annexin II serum recognized virion and cell surface annexin II and annexin II-derived peptides. Recombinant annexin II, with characteristic calcium- and phospholipid-binding activities, was also examined. Pretreatment of cells, virions or both with polyclonal anti-annexin II serum, affinity-purified anti-annexin II antibodies or recombinant annexin II protein prior to infection was inconsequential to the entry of HCMV into fibroblasts. HCMV was also able to dose-dependently penetrate annexin II-deficient 293 cells. Furthermore, the spread of HCMV from cell to cell was not inhibited in the presence of polyclonal anti-annexin II antibodies or exogenous annexin II protein. These experiments do not support a direct role of annexin II in virus entry or spread. Alternative roles for the gB-annexin II interaction are proposed.  (+info)

Mouse MHC class II Tetramer | MBL Life Science -JAPANMouse MHC class II Tetramer | MBL Life Science -JAPAN
C57BL/6 mice were immunized intraperitoneally twice with 100 nmol of I-Ab-restricted MOG35-55 peptide (MEVGWYRSPFSRVVHLYRNGK, MBL code no. TS-M704-P) and 10 µg cholera toxin (MBL code no. RK-01-511) in complete Freunds adjuvant. Eleven days later, splenocytes were isolated and stained with I-Ab MOG35-55 tetramer-PE (MBL code no. TS-M704-1; Day 0). An aliquot of splenocytes was stimulated with 10µg/mL MOG35-55 peptide for 6 days in vitro and then stained with MHC class II tetramer (Day 6). in vitro stimulation of with I-Ab MOG35-55 resulted in increased tetramer-positive CD4+ T cells from immunized (mouse 1 and 2), but not naïve (mouse 3), mice.. ...
http://ruo.mbl.co.jp/bio/e/product/allergy-Immunology/classII.html
anti-Annexin II antibody | GeneTexanti-Annexin II antibody | GeneTex
Annexin II antibody (annexin A2) for ICC/IF, IHC-P, IP, RipA, WB. Anti-Annexin II pAb (GTX32446) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
http://www.genetex.com/Annexin-II-antibody-GTX32446.html
Annexin A2 expression during cellular differentiation in myeloid cell lines | Biochemical Society TransactionsAnnexin A2 expression during cellular differentiation in myeloid cell lines | Biochemical Society Transactions
Annexin A2 is a calcium-dependent, phospholipid-binding protein found on many cell types. It consists of a short hydrophobic tail (Ser2-Asn32), which dictates its function, and a core domain (Phe33-Asp339), which is involved in phospholipid binding. Annexin A2 has been implicated in a number of biochemical processes, including cell proliferation, foetal immune tolerance, ion-channel activation, cell-cell interactions and the bridging of membranes. Annexin A2 is reported to be a powerful activator of plasminogen and, therefore, is implicated in many normal and pathological processes such as haemostasis and metastasis. Myeloid cell lines are used, extensively, to study many aspects of cellular proliferation, differentiation and function. In the present study, we have used flow cytometry and real-time PCR to investigate the role of annexin A2 expression in the proliferation and differentiation of a number of myeloid cell lines. The results demonstrated that annexin A2 expression was affected when ...
http://www.biochemsoctrans.org/content/32/6/1122
Recruitment of Annexin 2 to the Nascent Phagosome is an Essential Step in the Phagocytosis of Outer Segments by RPE Cells |...Recruitment of Annexin 2 to the Nascent Phagosome is an Essential Step in the Phagocytosis of Outer Segments by RPE Cells |...
Purpose: : To examine the role of annexin 2 in the formation and internalisation of phagosomes in retinal pigment epithelial (RPE) cells. Methods: : Human ARPE19 cells were cultured on the glass inserts of Matek dishes for immunofluorescence and live imaging, or plastic Nunc dishes for biochemical analysis. In some studies ARPE19 cells were exposed to siRNA for annexin 2 for three days prior to experimentation. Outer segments were prepared from porcine retina using standard protocols (typically 50 - 100 eyes per prep), and either used fresh in biochemical experiments, or labelled with an appropriate fluorescent marker prior to imaging experiments. Results: : Depletion of annexin 2 using siRNA led to a significant quantitative reduction in the phagocytosis of rod outer segments in cultured RPE cells. In cells expressing annexin 2, imaged by confocal microscopy, a striking enrichment of annexin 2 and F-actin was observed at the phagocytic cup immediately upon engagement of the apical cell surface ...
http://iovs.arvojournals.org/article.aspx?articleid=2395666
Trypsin and AnnexinTrypsin and Annexin
In our hands, the trypsin actually reduced the Annexin staining presumably by stripping off all the phosphotidyl-serine on the surface along with the surface proteins (adhesion molecules). The only time we have seen enhanced annexin is when the cells suffer enough trauma in harvesting that the membrane is not intact and the Annexin gets inside the cell and attaches to the ps on the inner membrane. Julie At 02:11 PM 8/18/98, you wrote: , ,I have a client who is staining with Annexin-FITC. They are looking at ,cell lines and are using trypsin to get the cells off the flasks. We are ,seeing what we think is an exagerated Annexin response. Does anyone out ,there have any feedback on how trypsin affects Annexin staining? Any ,experience and or information about this will be greatly appreciated. , Thanks in advance, , Joan Kalnitsky ,Joan Kalnitsky ,Flow Cytometry Laboratory ,VMRCVM ,(540) 231-4115 ,FAX 540-231-7367 , , It is better to serve than to receive , B. Borg , , , , , ...
https://lists.purdue.edu/pipermail/cytometry/1998-August/010871.html
Low-Dose Antigen Promotes Induction of FOXP3 in Human CD4+ T Cells | The Journal of ImmunologyLow-Dose Antigen Promotes Induction of FOXP3 in Human CD4+ T Cells | The Journal of Immunology
Low Ag dose promotes induction and persistence of regulatory T cells (Tregs) in mice, yet few studies have addressed the role of Ag dose in the induction of adaptive CD4+FOXP3+ Tregs in humans. To this end, we examined the level of FOXP3 expression in human CD4+CD25− T cells upon activation with autologous APCs and varying doses of peptide. Ag-specific T cells expressing FOXP3 were identified by flow cytometry using MHC class II tetramer (Tmr). We found an inverse relationship between Ag dose and the frequency of FOXP3+ cells for both foreign Ag-specific and self Ag-specific T cells. Through studies of FOXP3 locus demethylation and helios expression, we determined that variation in the frequency of Tmr+FOXP3+ T cells was not due to expansion of natural Tregs, but instead, we found that induction, proliferation, and persistence of FOXP3+ cells was similar in high- and low-dose cultures, whereas proliferation of FOXP3− T cells was favored in high Ag dose cultures. The frequency of FOXP3+ cells ...
http://www.jimmunol.org/content/early/2011/08/24/jimmunol.1003880
Longitudinal mapping of protective CD4+ T cell responses against HCV: analysis of fluctuating dominant and subdominant HLA-DR11...
Cellular immunity plays an important role in the control of persistent virus infections such as hepatitis C virus (HCV). Antiviral CD4(+) T cell responses have been shown to accompany resolution of acute disease and there is also a consistent association between HLA Class II genes, notably HLADRB1*1101 (and the closely linked HLADQB1*0301) and disease resolution. We initially mapped longitudinal CD4(+) T cell responses in an individual after spontaneous resolution of acute HCV, and identified three HLA-DR11-restricted responses which vary in immunodominance over time. Functional assays and HLA Class II tetramer staining revealed one to be a response to a commonly recognized epitope, NS3(1248-1261), although cytokine capture assays showed these specific cells to be at a very low frequency. In this patient, and in others reported, this most frequently recognized HLA-DR11 restricted epitope is not immunodominant. We analysed whether sequence variability within and between genotypes might account for
https://www.expmedndm.ox.ac.uk/publications/12179
Annexin A2 (C-terminal region) - ECM BiosciencesAnnexin A2 (C-terminal region) - ECM Biosciences
The Annexin family of calcium-binding proteins is composed of al least thirteen mammalian genes (Annexin A1-13). These proteins are characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner and a unique amino terminal region which may confer binding specificity. The Annexin family
https://ecmbio.com/products/am2981
Product Overview anti-Annexin A13 AntibodiesProduct Overview anti-Annexin A13 Antibodies
Order monoclonal and polyclonal Annexin A13 antibodies for many applications. Selected quality suppliers for anti-Annexin A13 antibodies.
http://www.antibodies-online.com/abstract/Annexin+A13+
Annexin A1抗体- Carboxyterminal end|Abcam中国|Anti-Annexin A1抗体- Carboxyterminal endAnnexin A1抗体- Carboxyterminal end|Abcam中国|Anti-Annexin A1抗体- Carboxyterminal end
Annexin A1兔多克隆抗体(ab65844)可与小鼠, 大鼠, 人样本反应并经WB, IP, IHC, ICC实验严格验证。所有产品均提供质保服务，中国75%以上现货。
http://www.abcam.cn/annexin-a1-antibody-carboxyterminal-end-ab65844.html
Annexin A2抗体|Abcam中国|Anti-Annexin A2抗体(ab90643)Annexin A2抗体|Abcam中国|Anti-Annexin A2抗体(ab90643)
Annexin A2兔多克隆抗体(ab90643)可与人样本反应并经WB, IHC实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。
http://www.abcam.cn/annexin-a2-antibody-ab90643.html
Anti-Annexin A10 antibody (ab2343) Protocols | AbcamAnti-Annexin A10 antibody (ab2343) Protocols | Abcam
Abcam provides specific protocols for Anti-Annexin A10 antibody (ab2343) : Western blot protocols, Immunohistochemistry protocols
http://www.abcam.com/annexin-a10-antibody-ab2343-protocols.html
ANXA4 Protein Human Recombinant | Annexin A4 | ProSpecANXA4 Protein Human Recombinant | Annexin A4 | ProSpec
ANXA4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 321 amino acids (1-321 a.a.) and having a molecular mass of 36 kDa.
https://www.prospecbio.com/anxa4_human
Pig Annexin A8(ANXA8) ELISA kit - E07A1548-192T B-Gene - Antibody-A...Pig Annexin A8(ANXA8) ELISA kit - E07A1548-192T B-Gene - Antibody-A...
Product Pig Annexin A8(ANXA8) ELISA kit From B-Gene - A competitive ELISA for quantitative measurement of Porcine Annexin A8(ANXA8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUTION*1 vial 12. WASH SOLUTION (100 x)*1 vial 13. BALANCE SOLUTION*1 vial 14. INSTRUCTION*1
https://antibody-antibodies.com/products/e07a1548-192t/pig-annexin-a8anxa8-elisa-kit-835397/
Annexin A3 | Profiles RNS
This graph shows the total number of publications written about Annexin A3 by people in this website by year, and whether Annexin A3 was a major or minor topic of these publications ...
https://profiles.umassmed.edu/display/109142
RCSB PDB - 5LGQ: Crystal structure of mouse CARM1 in complex with ligand P2C3sRCSB PDB - 5LGQ: Crystal structure of mouse CARM1 in complex with ligand P2C3s
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
https://www.rcsb.org/structure/5lgq
Anti-Annexin A10 antibody [EPR13101] (ab180182) | AbcamAnti-Annexin A10 antibody [EPR13101] (ab180182) | Abcam
Rabbit recombinant monoclonal Annexin A10 antibody [EPR13101] validated for WB and tested in Human, Mouse and Rat. Immunogen corresponding to recombinant…
http://www.abcam.com/annexin-a10-antibody-epr13101-ab180182.html
AID 502910 - Induction of annexin 2-mediated cytoskeleton aggregate accumulation in human HepG2 cells at 4 uM after 2 hrs by...AID 502910 - Induction of annexin 2-mediated cytoskeleton aggregate accumulation in human HepG2 cells at 4 uM after 2 hrs by...
BioAssay record AID 502910 submitted by ChEMBL: Induction of annexin 2-mediated cytoskeleton aggregate accumulation in human HepG2 cells at 4 uM after 2 hrs by confocal laser scanning microscopy.
https://pubchem.ncbi.nlm.nih.gov/bioassay/502910
Annexin A11 Antibody 10479-2-AP | ProteintechAnnexin A11 Antibody 10479-2-AP | Proteintech
Annexin A11 Antibody 10479-2-AP has been identified with IF, IHC, IP, WB, ELISA. 10479-2-AP detected 56-60 kDa band in HeLa cells with 1:500-1:2000 dilution...
https://www.ptglab.com/products/ANXA11-Antibody-10479-2-AP.htm
Annexin A1 (1-25) (dephosphorylated) (human) H-3196 | BachemAnnexin A1 (1-25) (dephosphorylated) (human) H-3196 | Bachem
Bachem offers H-3196 Annexin A1 (1-25) (dephosphorylated) (human) for your research. Find all specific details here. Find product specific information including available pack sizes, CAS, detailed description and references here.
http://shop.bachem.com/h-3196.html
Annexin A3 Antibody (2F3) (NBP2-03373): Novus BiologicalsAnnexin A3 Antibody (2F3) (NBP2-03373): Novus Biologicals
Mouse Monoclonal Anti-Annexin A3 Antibody (2F3). Validated: WB, ICC/IF, IHC, IHC-P. Tested Reactivity: Human, Monkey. 100% Guaranteed.
https://www.novusbio.com/products/annexin-a3-antibody-2f3_nbp2-03373
Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes ...Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes ...
Because of its Ca2+-regulated actin and membrane binding properties, annexin 2 is a probable candidate for participating in the regulation of actin assembly and/or the formation of membrane-cytoskeleton links at certain membrane sites. This is supported by several reports revealing a relationship between annexin 2 and the actin cytoskeleton that underlies cellular membranes (Babiychuk and Draeger, 2000; Harder and Gerke, 1993; Harder and Gerke, 1994; Merrifield et al., 2001; Oliferenko et al., 1999; Zobiack et al., 2002). Recently, annexin 2 was found to be specifically enriched at the membrane-F-actin interface of motile pinosomes (Merrifield et al., 2001). The formation of macropinosome actin tails was inhibited by the overexpression of a trans-dominant annexin 2 mutant protein, which revealed an essential role for annexin 2 in the generation of these structures. However, the finding that annexin 2 is not recruited to actin tails assembled behind moving Listeria, shows that annexin 2 is not ...
https://jcs.biologists.org/content/117/16/3473
Cleavage of Annexin A1 by ADAM10 during Secondary Necrosis Generates a Monocytic Find-Me Signal | The Journal of ImmunologyCleavage of Annexin A1 by ADAM10 during Secondary Necrosis Generates a Monocytic Find-Me Signal | The Journal of Immunology
Annexin A1 is an intracellular calcium/phospholipid-binding protein that is involved in membrane organization and the regulation of the immune system. It has been attributed an anti-inflammatory role at various control levels, and recently we could show that annexin A1 externalization during secondary necrosis provides an important fail-safe mechanism counteracting inflammatory responses when the timely clearance of apoptotic cells has failed. As such, annexin A1 promotes the engulfment of dying cells and dampens the postphagocytic production of proinflammatory cytokines. In our current follow-up study, we report that exposure of annexin A1 during secondary necrosis coincided with proteolytic processing within its unique N-terminal domain by ADAM10. Most importantly, we demonstrate that the released peptide and culture supernatants of secondary necrotic, annexin A1-externalizing cells induced chemoattraction of monocytes, which was clearly reduced in annexin A1- or ADAM10-knockdown cells. Thus, ...
http://www.jimmunol.org/content/early/2011/11/23/jimmunol.1004073
Annexin V Kits Archives - TrevigenAnnexin V Kits Archives - Trevigen
Early in the apoptosis process, phosphatidylserine (PS) becomes exposed on the cell surface by flipping from the inner to outer leaflet of the cytoplasmic membrane. This event is thought to be important for macrophage recognition of cells undergoing apoptosis, thus allowing the cells to be rapidly phagocytosed. The binding of Annexin V to phosphatidylserine is calcium-dependent, reversible, but very tight, with a Kd of approximately 5 x 10-10 M. At low PS concentration, a binding ratio of 8 annexins to one PS has been reported. These features make Annexin V conjugates ideal for identifying membrane changes associated with apoptosis, by using either flow cytometric or in situ labeling methods. TACS® Annexin V kits are supplied with an Annexin V conjugate, an optimized binding buffer and propidium iodide. Cells are harvested and washed, then incubated with an Annexin V conjugate in binding buffer, for 15 minutes at room temperature prior to direct analysis. Alternatively, a secondary streptavidin ...
https://trevigen.com/product-category/cell-stress-and-dna-damage/apoptosis/annexin-v-assays/cell-stress-and-dna-damage-apoptosis-annexin-v-assays-kits/
JCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injuryJCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injury
Membrane repair is essential to cell survival. In skeletal muscle, injury often associates with plasma membrane disruption. Additionally, muscular dystrophy is linked to mutations in genes that produce fragile membranes or reduce membrane repair. Methods to enhance repair and reduce susceptibility to injury could benefit muscle in both acute and chronic injury settings. Annexins are a family of membrane-associated Ca2+-binding proteins implicated in repair, and annexin A6 was previously identified as a genetic modifier of muscle injury and disease. Annexin A6 forms the repair cap over the site of membrane disruption. To elucidate how annexins facilitate repair, we visualized annexin cap formation during injury. We found that annexin cap size positively correlated with increasing Ca2+ concentrations. We also found that annexin overexpression promoted external blebs enriched in Ca2+ and correlated with a reduction of intracellular Ca2+ at the injury site. Annexin A6 overexpression reduced membrane ...
https://huanyu58.com.insight.mobile.jci.org/articles/view/128840/ga
Annexin V-Cy3 Apoptosis Detection Kit | GeneTexAnnexin V-Cy3 Apoptosis Detection Kit | GeneTex
Annexin V Apoptosis Detection Kit is based on the observation that soon after initiating apoptosis, cells translocate the membrane phosphatidyl-serine (PS) from the inner face of the plasma membrane to the cell surface. Once on the cell surface, PS can be easily detected by staining with a fluorescent conjugate of Annexin V, a protein that has a high affinity for PS. The one-step staining procedure takes only 10 minutes. Detection can be analyzed by flow cytometry or by fluorescence microscopy. |p>|br />|br />‧ Detection method- Flow cytometry (Ex = 543 nm; Em = 570 nm) and fluorescence microscopy |br>|br />‧ Sample type- Living cells (suspension and adherant)|br>|br />‧ Species reactivity- Mammalian |br />|br />|br />|p>|b>Features and Benefits|/b>|br>|br />‧ Simple one step staining procedure in 10 minutes|br>|br />‧ Fast and convenient|br>|br />‧ Cy3 shows brighter red fluorescence|br />|br />|br />|br />|p>|b>Kit Contents:|/b>|br>|br />Annexin V-Cy3|br>|br />1X Binding Buffer, Annexin V
http://www.genetex.com/Annexin-V-Cy3-Apoptosis-Detection-Kit-GTX85590.html
Annexins sense changes in intracellular pH during hypoxia | Biochemical JournalAnnexins sense changes in intracellular pH during hypoxia | Biochemical Journal
The pHi (intracellular pH) is an important physiological parameter which is altered during hypoxia and ischaemia, pathological conditions accompanied by a dramatic decrease in pHi. Sensors of pHi include ion transport systems which control intracellular Ca2+ gradients and link changes in pHi to functions as diverse as proliferation and apoptosis. The annexins are a protein family characterized by Ca2+-dependent interactions with cellular membranes. Additionally, in vitro evidence points to the existence of pH-dependent, Ca2+-independent membrane association of several annexins. We show that hypoxia promotes the interaction of the recombinant annexin A2-S100A10 (p11) and annexin A6 with the plasma membrane. We have investigated in vivo the influence of the pHi on the membrane association of human annexins A1, A2, A4, A5 and A6 tagged with fluorescent proteins, and characterized this interaction for endogenous annexins present in smooth muscle and HEK (human embryonic kidney)-293 cells ...
http://www.biochemj.org/content/409/1/65
Annexin A2: Its molecular regulation and cellular expression in cancer development<...
TY - JOUR. T1 - Annexin A2. T2 - Its molecular regulation and cellular expression in cancer development. AU - Wang, Chi Yun. AU - Lin, Chiou Feng. PY - 2014. Y1 - 2014. N2 - Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 affects its cellular localization and function. However, posttranslational modification and protease-mediated N-terminal cleavage also play critical roles in regulating ANXA2. ANXA2 expression levels vary among different types of cancers. With some cancers, ANXA2 can be used for the detection and diagnosis of cancer and for monitoring cancer progression. ANXA2 is also required for drug-resistance. This review discusses the feasibility of ANXA2 which is active in cancer development and can be a therapeutic target in cancer management.. AB - Annexin A2 (ANXA2) orchestrates multiple biologic processes and clinical associations, especially in cancer progression. The structure of ANXA2 ...
https://tmu.pure.elsevier.com/en/publications/annexin-a2-its-molecular-regulation-and-cellular-expression-in-ca
PE/Cy7 Annexin VPE/Cy7 Annexin V
|p|Annexin V (or Annexin A5) is a member of the annexin family of intracellular proteins that binds to phosphatidylserine (PS) in a calcium-dependent manner. PS is normally only found on the intracellular leaflet of the plasma membrane in healthy cells, but during early apoptosis, membrane asymmetry
https://www.biolegend.com/nl-nl/products/pe-cy7-annexin-v-14931
Invitrogen™ eBioscience™ Annexin V, Recombinant Protein Unlabeled; 300μg Invitrogen™ eBioscience™ Annexin V, Recombinant ProteinInvitrogen™ eBioscience™ Annexin V, Recombinant Protein Unlabeled; 300μg Invitrogen™ eBioscience™ Annexin V, Recombinant Protein
Invitrogen™ eBioscience™ Annexin V, Recombinant Protein Unlabeled; 300μg Invitrogen™ eBioscience™ Annexin V, Recombinant Protein...
https://www.fishersci.co.uk/shop/products/mouse-il-33-recombinant-protein/15571907
Annexin V Binding BufferAnnexin V Binding Buffer
Annexin V Binding Buffer - Annexin V Binding Buffer has been formulated for flow cytometric labeling of apoptotic cells with Annexin V reagents.  The buffer is provided as a ready-to-use solution..
https://production-dynamicweb.biolegend.com/de-at/products/annexin-v-binding-buffer-5162
Aniara ZYMUTEST Anti-Annexin V, IgMAniara ZYMUTEST Anti-Annexin V, IgM
ELISA method for the measurement of IgM isotype auto antibodies targeted to annexin V. Assay designed with highly purified human recombinant annexin V, obtained with non-denaturing methods, for auto antibody immunocapture. These are then revealed with a goat antibody specific for IgM, micro fragments, and labeled with peroxidase.
http://www.aniara.com/mm5/merchant.mvc?Store_code=ANIA&Screen=PROD&Product_Code=ARK005B
Placenta a annexin V receptory, protilátky proti annexinu V a proti ostatním fosfolipidům u žen opakovaně potrácejících | Česká...Placenta a annexin V receptory, protilátky proti annexinu V a proti ostatním fosfolipidům u žen opakovaně potrácejících | Česká...
We examined sera and placenta tissue from 156 patients in reproductive age with unexplained repeated pregnancy loss. Control group of eighty-four fertile healthy women was included. ELISA methods were used for detecting a panel of sera of anti-phospholipid antibodies (aPLs). Immunolocalization of annexin V receptors in 143 trophoblast-placenta specimen of 156 patients was investigated by the immunofluorescence technique using Annexin V-FITC, Apoptosis and Annexin V-CY3 commercial kits ...
https://www.cs-gynekologie.cz/casopisy/ceska-gynekologie/2006-6/placenta-a-annexin-v-receptory-protilatky-proti-annexinu-v-a-proti-ostatnim-fosfolipidum-u-zen-opakovane-potracejicich-4664
C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...C-Reactive Protein and Annexin A5 Bind to Distinct Sites of Negatively Charged Phospholipids Present in Oxidized Low-Density...
In the present study, we show that both CRP and annexin A5 specifically bind to oxidized LDL. Via coupling to Fcγ receptors on macrophages and independent of complement, CRP subsequently enhances the association of oxidized LDL to macrophages. Enhanced association of oxidized LDL to macrophages via CRP-Fcγ receptor interaction may lead to enhanced macrophage uptake of oxidized LDL. Moreover, we show that annexin A5 binds to a site at oxidized LDL different from the CRP binding site and that annexin A5 does not antagonize the CRP effect.. Previously, Chang et al also observed specific binding of CRP to oxidized LDL,7 characterized by inhibition by whole molecules as well as F(ab′)2 fragments of EO6, an IgM antibody that binds specifically to the phosphorylcholine head group of oxidized phospholipids but not to the same moiety on nonoxidized phospholipids.26 In the present study, for characterization of binding sites, we used the monoclonal antibody DLH3 (also IgM), which recognizes an epitope ...
http://atvb.ahajournals.org/content/25/4/717
Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. - Science ExchangeAnnexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. - Science Exchange
Annexin 1 is an anti-inflammatory protein that plays a key role in innate immunity by modulating the activation of several types of cells, including neutrophils. Here we have developed a cleavage assay using tagged annexin 1 and observed marked activity in the membrane fraction of activated neutrophils. A combination of inhibitors, transfected cells, and proteomic analyses allowed us to identify proteinase 3 as the main enzyme responsible for this cleavage in the N terminus region of the protein, at least in the context of neutrophil activation. Because annexin 1 is an important endogenous anti-inflammatory mediator, blocking its cleavage by proteinase 3 would augment its homeostatic pro-resolving actions and could represent an opportunity for innovative anti-inflammatory drug discovery.. ...
https://www.scienceexchange.com/publications/1762
annexin,cell detection,TransDetect® Annexin V-EGFP/PI Cell Apoptosis Detection Kit,Cell Detecti
TransDetect® Annexin V-EGFP/PI Cell Apoptosis Detection Kit,Cell Detection,Cell Culture and Detection,Products,Beijing TransGen Biotech Co.Ltd,OverviewContents& storageCitations & referencesRelated ImagesDownloadOverviewDescriptionThe Annexin V
http://www.transbionovo.com/rx_detail/productId=340.html
Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex.</strong>...
TY - JOUR. T1 - Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex. AU - Hankins, Jody L.. AU - Ward, Katherine E.. AU - Linton, Sam S.. AU - Barth, Brian M.. AU - Stahelin, Robert V.. AU - Fox, Todd E.. AU - Kester, Mark. PY - 2013/7/5. Y1 - 2013/7/5. N2 - The bioactive sphingolipid, ceramide 1-phosphate (C-1-P), has been implicated as an extracellular chemotactic agent directing cellular migration in hematopoietic stem/progenitor cells and macrophages. However, interacting proteins that could mediate these actions of C-1-P have, thus far, eluded identification. We have now identified and characterized interactions between ceramide 1-phosphate and the annexin a2-p11 heterotetramer constituents. This C-1-P-receptor complex is capable of facilitating cellular invasion. Herein, we demonstrate in both coronary artery macrovascular endothelial cells and retinal microvascular endothelial cells that C-1-P induces invasion through an ...
https://indiana.pure.elsevier.com/en/publications/ceramide-1-phosphate-mediates-endothelial-cell-invasion-via-the-a
ANXA5 Protein Mouse Recombinant | Annexin A5 | ProSpecANXA5 Protein Mouse Recombinant | Annexin A5 | ProSpec
ANXA5 Mouse Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain containing 342 amino acids (1-319 a.a) and having a molecular mass of 38.1kDa.
https://www.prospecbio.com/anxa5_mouse
JCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injuryJCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injury
Animals. Wild-type mice from the 129T2/SvEmsJ background were bred and housed in a specific pathogen-free facility on a 12-hour light/12-hour dark cycle and fed ad libitum in accordance with the Northwestern Universitys Institutional Animal Care and Use Committee regulations. 129T2/SvEmsJ (129T2) mice were purchased from the Jackson Laboratory (stock 002065). mdx/hLTBP4 mice were generated as described previously (34, 60). Sgcg-null mice were generated as described in Hack et al. (46). Two- to 3-month-old males and females were used for all wild-type mouse experiments. Sgcg-null cohorts were age and sex matched with mice between 2 and 5 months old.. Plasmids. Plasmids encoding annexin A1, A2, and A6 with a carboxyl-terminal turboGFP tag were obtained from Origene. Subcloning of annexin A1, A2, and A6 to replace the GFP tag with tdTomato (Addgene) was performed by Mutagenix. Site-directed mutagenesis was performed by Mutagenix on annexin A1-GFP, A2-GFP, and A6-GFP to create the Ca2+-binding ...
https://yctianyuan.net.insight.mobile.jci.org/articles/view/128840
JCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injuryJCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injury
Animals. Wild-type mice from the 129T2/SvEmsJ background were bred and housed in a specific pathogen-free facility on a 12-hour light/12-hour dark cycle and fed ad libitum in accordance with the Northwestern Universitys Institutional Animal Care and Use Committee regulations. 129T2/SvEmsJ (129T2) mice were purchased from the Jackson Laboratory (stock 002065). mdx/hLTBP4 mice were generated as described previously (34, 60). Sgcg-null mice were generated as described in Hack et al. (46). Two- to 3-month-old males and females were used for all wild-type mouse experiments. Sgcg-null cohorts were age and sex matched with mice between 2 and 5 months old.. Plasmids. Plasmids encoding annexin A1, A2, and A6 with a carboxyl-terminal turboGFP tag were obtained from Origene. Subcloning of annexin A1, A2, and A6 to replace the GFP tag with tdTomato (Addgene) was performed by Mutagenix. Site-directed mutagenesis was performed by Mutagenix on annexin A1-GFP, A2-GFP, and A6-GFP to create the Ca2+-binding ...
https://tszhwy.com.insight.mobile.jci.org/articles/view/128840
JCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injuryJCI - Recombinant annexin A6 promotes membrane repair and protects against muscle injury
Animals. Wild-type mice from the 129T2/SvEmsJ background were bred and housed in a specific pathogen-free facility on a 12-hour light/12-hour dark cycle and fed ad libitum in accordance with the Northwestern Universitys Institutional Animal Care and Use Committee regulations. 129T2/SvEmsJ (129T2) mice were purchased from the Jackson Laboratory (stock 002065). mdx/hLTBP4 mice were generated as described previously (34, 60). Sgcg-null mice were generated as described in Hack et al. (46). Two- to 3-month-old males and females were used for all wild-type mouse experiments. Sgcg-null cohorts were age and sex matched with mice between 2 and 5 months old.. Plasmids. Plasmids encoding annexin A1, A2, and A6 with a carboxyl-terminal turboGFP tag were obtained from Origene. Subcloning of annexin A1, A2, and A6 to replace the GFP tag with tdTomato (Addgene) was performed by Mutagenix. Site-directed mutagenesis was performed by Mutagenix on annexin A1-GFP, A2-GFP, and A6-GFP to create the Ca2+-binding ...
https://www.jci.org/articles/view/128840
Annexin V Apoptosis Assay - Phosphatidylserine Detection by Annexin VAnnexin V Apoptosis Assay - Phosphatidylserine Detection by Annexin V
Annexin V Apoptosis Assay - Phosphatidylserine Detection by Annexin VAnnexin V Apoptosis Assay - Phosphatidylserine Detection by Annexin V
Annexin V Antibody | AbbiotecAnnexin V Antibody | Abbiotec
Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V is a monomer, binds ATRX and EIF5B, and interacts with hepatitis B virus (HBV ...
http://www.abbiotec.com/antibodies/annexin-v-antibody-1
PRINTS Search
SCAN HISTORY OWL11_0 2 100 NSINGLE OWL17_1 2 110 NSINGLE OWL18_0 1 115 NSINGLE OWL19_1 1 125 NSINGLE OWL21_1 1 125 NSINGLE OWL26_0 1 125 NSINGLE SPTR37_9f 2 237 NSINGLE INITIAL MOTIF SETS ANNEXIN1 Length of motif = 23 Motif number = 1 Annexin motif I - 1 PCODE ST INT KTKGVDEVTIVNILTNRSNAQRQ LUHU36 46 46 KTKGVDEVTIINILTNRSNEQRQ ANX2_CHICK 46 46 TVKGVDEATIIDILTKRNNAQRQ ANX1_CAVCU 56 56 MVKGVDEATIIDILTKRNNAQRQ LUHU 55 55 KGIGTDEATIIDIVTHRSNAQRQ ANX6_MOUSE 376 376 KGMGTDEETILKILTSRNNAQRQ ANX5_CHICK 29 29 KGIGTNEQAIIDVLTKRSNTQRQ ANX8_HUMAN 35 35 KGFGTDEQEIIDVLVGRSNQQRQ DROANNX 29 29 RGIGTDEKMLISILTERSNAQRQ ANX3_HUMAN 32 32 KGLGTDEDAIINVLAYRSTAQRQ ANX4_BOVIN 27 27 KGFGTDEQAIVDVVANRSNDQRQ HUMSNEXIN 177 177 TAKGVDEATIIDIMTTRTNAQRP ANX1_COLLI 51 51 ANNEXIN2 Length of motif = 17 Motif number = 2 Annexin motif II - 1 PCODE ST INT LKSALSGHLETVILGLL LUHU36 86 17 LKSALSGHLEAVILGLL ANX2_CHICK 86 17 LKKALTGHLEEVVLALL ANX1_CAVCU 96 17 LKKALTGHLEEVVLALL LUHU 95 17 LKSEISGDLARLILGLM ANX6_MOUSE 416 17 ...
http://130.88.97.239/cgi-bin/dbbrowser/PRINTS/DoPRINTS.pl?cmd_a=Display&qua_a=/Full&fun_a=Code&qst_a=ANNEXIN
ANXA2 recombinant protein | Annexin A2 Recombinant Protein-NP 001002857ANXA2 recombinant protein | Annexin A2 Recombinant Protein-NP 001002857
Buy ANXA2 recombinant protein, Annexin A2 Recombinant Protein-NP_001002857 (MBS203687) product datasheet at MyBioSource, Recombinant Proteins. Application: SDS-PAGE
https://www.mybiosource.com/prods/Recombinant-Protein/Annexin-A2/ANXA2/datasheet.php?products_id=203687
Gentaur Molecular :Biovis \ Annexin V Unlabeled Reagent5 mg \ 1005-5000Gentaur Molecular :Biovis \ Annexin V Unlabeled Reagent5 mg \ 1005-5000
Gentaur molecular products has all kinds of products like :search , Biovis \ Annexin V Unlabeled Reagent5 mg \ 1005-5000 for more molecular products just contact us
http://www.antibody-antibodies.com/product_det.php?id=187672&supplier=search&name=Annexin%20V%20Unlabeled%20Reagent5%20mg
Sequence Similarity - 1HVD: STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN...Sequence Similarity - 1HVD: STRUCTURAL AND ELECTROPHYSIOLOGICAL ANALYSIS OF ANNEXIN V MUTANTS. MUTAGENESIS OF HUMAN...
1HVD: Structural and electrophysiological analysis of annexin V mutants. Mutagenesis of human annexin V, an in vitro voltage-gated calcium channel, provides information about the structural features of the ion pathway, the voltage sensor and the ion selectivity filter
http://www.rcsb.org/pdb/explore/sequenceCluster.do?structureId=1HVD
ANXA1 Gene - GeneCards | ANXA1 Protein | ANXA1 AntibodyANXA1 Gene - GeneCards | ANXA1 Protein | ANXA1 Antibody
Complete information for ANXA1 gene (Protein Coding), Annexin A1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ANXA1&rf=/home/genecards/current/website/carddisp.pl&bioalma_dis_art=all
ANXA1 Gene - GeneCards | ANXA1 Protein | ANXA1 AntibodyANXA1 Gene - GeneCards | ANXA1 Protein | ANXA1 Antibody
Complete information for ANXA1 gene (Protein Coding), Annexin A1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ANXA1&rf=/home/genecards/current/website/carddisp.pl&origene_full_trans=2
October 7, 2015 - Autophagy UK Network
Annexin A2 is a calcium regulated protein involved in membrane binding and actin polymerization. In this paper, Kevin Moreau and colleagues identified Annexin A2 as a…. ...
http://autophagy.uk/2015/10/07/
Rabbit Anti-ANXA10 (Annexin A10) polyclonal antibody - Protein AlternativesRabbit Anti-ANXA10 (Annexin A10) polyclonal antibody - Protein Alternatives
This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may have an effect on your browsing experience ...
https://proteinalternatives.com/producto/rabbit-anti-anxa10-annexin-a10-polyclonal-antibody/
Genatlas sheet
E1 beta subunit of the complex forming an heterotetramer alpha2beta2 bound to two TPP (thiamine-pyrophosphate) one each bridging E1 alpha and E1 beta to form an active site catalyzing the irreversible decarboxylation of pyruvate to acetyl- ...
http://genatlas.medecine.univ-paris5.fr/fiche.php?symbol=PDHB
Annexin A2Annexin A2
... also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. Annexin 2 is involved in diverse ... Kwon M, MacLeod TJ, Zhang Y, Waisman DM (January 2005). "S100A10, annexin A2, and annexin a2 heterotetramer as candidate ... "Entrez Gene: ANXA2 annexin A2". Kling T, Ferrarese R, Ó hAilín D, Johansson P, Heiland DH, Dai F, et al. (October 2016). " ... Annexin A2 has been proposed to function inside the cell in sorting of endosomes and outside the cell in anticoagulant ...
https://en.wikipedia.org/wiki/Annexin_A2
Jean GruenbergJean Gruenberg
Morel, Etienne; Gruenberg, Jean (2007-10-31). "The p11/S100A10 Light Chain of Annexin A2 Is Dispensable for Annexin A2 ... Annexin A2 (previously named Annexin II), the vacuolar ATPase, COP coat proteins, the N-ethylmaleimide sensitive factor, the ... Morel, Etienne; Gruenberg, Jean (2009-01-16). "Annexin A2 binding to endosomes and functions in endosomal transport are ... Morel, Etienne; Parton, Robert G.; Gruenberg, Jean (2009). "Annexin A2-dependent polymerization of actin mediates endosome ...
https://en.wikipedia.org/wiki/Jean_Gruenberg
CEACAM1CEACAM1
... has been shown to interact with PTPN11 and Annexin A2. Carcinoembryonic antigen Cluster of differentiation GRCh38: ... Kirshner J, Schumann D, Shively JE (December 2003). "CEACAM1, a cell-cell adhesion molecule, directly associates with annexin ...
https://en.wikipedia.org/wiki/CEACAM1
VomocytosisVomocytosis
Annexin A2, a membrane-bound protein, helps regulate vomocytosis and promote the fusing of vesicles to the plasma membranes. In ... annexin A2 deficient cell lines, rates of vomocytosis were decreased. Furthermore, screens of macrophage kinase inhibitors ...
https://en.wikipedia.org/wiki/Vomocytosis
HPG80HPG80
One candidate is Annexin A2, identified as being able of binding progastrin and derived peptides. Annexin A2 is a partial ... However, progastrin affinity for Annexin A2 is not what would be expected for a specific receptor. And, although Annexin A2 ... In particular, Annexin A2 mediates NF-kappaB upregulation and β-catenin in response to progastrin in mice and HEK-293 cells. In ... Sarkar, Shubhashish; Swiercz, Rafal; Kantara, Carla; Hajjar, Katherine A.; Singh, Pomila (2011). "Annexin A2 Mediates Up- ...
https://en.wikipedia.org/wiki/HPG80
PCSK9PCSK9
2012). "Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation". PLOS ONE. 7 (7): e41865 ... Annexin A2, an endogenous protein, is a natural inhibitor of PCSK9 activity. GRCh38: Ensembl release 89: ENSG00000169174 - ... Mayer G, Poirier S, Seidah NG (November 2008). "Annexin A2 is a C-terminal PCSK9-binding protein that regulates endogenous low ...
https://en.wikipedia.org/wiki/PCSK9
Ubiquitin CUbiquitin C
He KL, Deora AB, Xiong H, Ling Q, Weksler BB, Niesvizky R, Hajjar KA (July 2008). "Endothelial cell annexin A2 regulates ...
https://en.wikipedia.org/wiki/Ubiquitin_C
SLPISLPI
Additionally, it has been shown that SLPI is able to bind the Annexin A2/S100A10 heterotetramer (A2t), a co-factor HIV ... "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLOS ONE. 7 (8): ... "Secretory leukocyte protease inhibitor binds to annexin II, a cofactor for macrophage HIV-1 infection". The Journal of ...
https://en.wikipedia.org/wiki/SLPI
Human papillomavirus infectionHuman papillomavirus infection
2012). "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLOS ONE ... and annexin A2 leading to entry of the virions into basal epithelial cells through clathrin-mediated endocytosis and/or ...
https://en.wikipedia.org/wiki/Human_papillomavirus_infection
DysferlinDysferlin
Lennon NJ, Kho A, Bacskai BJ, Perlmutter SL, Hyman BT, Brown RH (2003). "Dysferlin interacts with annexins A1 and A2 and ... including annexin and MG53. Exactly how dysferlin contributes to membrane resealing is not clear, but biochemical evidence ... "Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal ...
https://en.wikipedia.org/wiki/Dysferlin
RAB3DRAB3D
Knop M, Aareskjold E, Bode G, Gerke V (2005). "Rab3D and annexin A2 play a role in regulated secretion of vWF, but not tPA, ...
https://en.wikipedia.org/wiki/RAB3D
ProhibitinProhibitin
"Prohibitin and prohibitone are contained in high-molecular weight complexes and interact with alpha-actinin and annexin A2". ...
https://en.wikipedia.org/wiki/Prohibitin
CochlinCochlin
Goel M, Sienkiewicz AE, Picciani R, Lee RK, Bhattacharya SK (2011). "Cochlin induced TREK-1 co-expression and annexin A2 ...
https://en.wikipedia.org/wiki/Cochlin
Langerhans cellLangerhans cell
Specifically, HPV16 entry into Langerhans cells via the annexin A2/S100A10 heterotetramer results in suppressive signaling and ... a novel role for the annexin A2 heterotetramer in immune suppression". Journal of Immunology. 192 (10): 4748-4757. doi:10.4049/ ...
https://en.wikipedia.org/wiki/Langerhans_cell
S100A10S100A10
Kwon M, MacLeod TJ, Zhang Y, Waisman DM (Jan 2005). "S100A10, annexin A2, and annexin a2 heterotetramer as candidate ... He KL, Deora AB, Xiong H, Ling Q, Weksler BB, Niesvizky R, Hajjar KA (Jul 2008). "Endothelial cell annexin A2 regulates ... Annexin II, which is attracted to negatively charged phospholipids, binds to p11 at the Ca2+ binding site. In addition, Annexin ... "The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection". PLOS ONE. 7 (8): ...
https://en.wikipedia.org/wiki/S100A10
AnnexinAnnexin
However some annexins (Annexin A1, Annexin A2, and Annexin A5) can be secreted from the cytoplasm to outside cellular ... Annexin, type I InterPro: IPR002388 Annexin, type II InterPro: IPR002389 Annexin, type III InterPro: IPR002390 Annexin, type IV ... Annexin is also known as lipocortin. Lipocortins suppress phospholipase A2. Increased expression of the gene coding for annexin ... In addition to annexin A-II, annexin A-XI has also been shown to organize cell membrane properties. Annexin A-XI is believed to ...
https://en.wikipedia.org/wiki/Annexin
Elizabeth JaffeeElizabeth Jaffee
With further research and development, Jaffee has hopes to make the protein, Annexin A2, not as overworked to prevent the ... Annexina2 as Immunological Target, and Prostate Stem Cell Antigen Vaccines and Uses Thereof. In 2007, Dr. Elizabeth Jaffee co- ...
https://en.wikipedia.org/wiki/Elizabeth_Jaffee
Embryo qualityEmbryo quality
Two examples of proteins that may be included in maternal profiling are endometrium-derived stathmin and annexin A2, whose down ...
https://en.wikipedia.org/wiki/Embryo_quality
AlclometasoneAlclometasone
... formally known as annexins, which inhibit phospholipase A2 - the enzyme responsible for the synthesis of arachidonic acid. ...
https://en.wikipedia.org/wiki/Alclometasone
List of MeSH codes (D12.776.157)List of MeSH codes (D12.776.157)
... annexin a1 MeSH D12.776.157.125.050.060 - annexin a2 MeSH D12.776.157.125.050.070 - Annexin A3 MeSH D12.776.157.125.050.080 - ... annexin a4 MeSH D12.776.157.125.050.100 - annexin a5 MeSH D12.776.157.125.050.110 - annexin a6 MeSH D12.776.157.125.050.120 - ... annexin a7 MeSH D12.776.157.125.412.249 - calmodulin MeSH D12.776.157.125.412.311 - calnexin MeSH D12.776.157.125.412.374 - ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)
Proliferating cell nuclear antigenProliferating cell nuclear antigen
Annexin A2, CAF-1, CDC25C, CHTF18, Cyclin D1, Cyclin O, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1C, DNMT1 ...
https://en.wikipedia.org/wiki/Proliferating_cell_nuclear_antigen
A2A2
... a protein that in humans is encoded by the EDA2R gene Alpha-2 adrenergic receptor Annexin A2, a protein Apolipoprotein A2, a ... A2, A02, A002, A², A.II or A-2 may refer to: British NVC community A2 (Lemna minor community), a plant community A2, the second ... A2, an Italian Baseball League A2, an Italian Volleyball League A2, a grade in climbing A2 (remote television production), a ... an enzyme Hemoglobin A2, a protein Proanthocyanidin A2, an A type proanthocyanidin Urea transporter A2, a protein A2, a variant ...
https://en.wikipedia.org/wiki/A2
TMEM155TMEM155
Cytogenetic band: 4q27 TMEM155 is neighbored by TMEM155 is neighbored on chromosome 4 by CCNA2, a gene encoding for cyclin A2, ... and ANXA5, which encodes annexin A5. It is also neighbored by PP12613 located on the positive strand. The gene on chromosome 4 ...
https://en.wikipedia.org/wiki/TMEM155
CatgripCatgrip
... s are found as calcium-binding features in annexins, matrix metalloproteinases (e.g.serralysins), subtilisins and ... phospholipase A2. They are also observed in synthetic peptides and in cyclic hexapeptides made from alternating D,L amino acids ...
https://en.wikipedia.org/wiki/Catgrip
Annexin A5Annexin A5
"Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against ... Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect ... The annexin A5 affinity assay typically uses a conjugate of annexin V and a fluorescent or enzymatic label, biotin or other ... Annexin A5 showed upregulation in papillary thyroid carcinoma. Annexin A5 is used as a non-quantitative probe to detect cells ...
https://en.wikipedia.org/wiki/Annexin_A5
Annexin A1Annexin A1
... protein has an apparent relative molecular mass of 40 kDa with phospholipase A2 inhibitory activity. Glucocorticoids ... Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 belongs to the ... Annexin A1 both suppresses phospholipase A2, thereby blocking eicosanoid production, and inhibits various leukocyte ... Annexin A1 has also been shown to be associated with treatment resistance. ARID1A loss activates annexin A1 expression, which ...
https://en.wikipedia.org/wiki/Annexin_A1
Annexin A3Annexin A3
This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1- ... "The high-resolution crystal structure of human annexin III shows subtle differences with annexin V.". Biochemistry. 35 (6): ... Annexin A3 is a protein that in humans is encoded by the ANXA3 gene. It is abnormally expressed in fetuses of both IVF and ICSI ... "Entrez Gene: ANXA3 annexin A3". Zhang Y, Zhang YL, Feng C, et al. (September 2008). "Comparative proteomic analysis of human ...
https://en.wikipedia.org/wiki/Annexin_A3
GlucocorticoidGlucocorticoid
... annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2, thereby blocking eicosanoid production, and inhibits ... They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase/PGE isomerase ( ... "Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo- ...
https://en.wikipedia.org/wiki/Glucocorticoid
Immunosuppressive drugImmunosuppressive drug
They induce the lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from ...
https://en.wikipedia.org/wiki/Immunosuppressive_drug
Prostaglandin inhibitorsProstaglandin inhibitors
Phospholipase A2 is an enzyme to catalyze the release of arachidonic acid in our body. After arachidonic acid is released, it ... Yazid, Samia; Norling, Lucy V.; Flower, Rod J. (2012-08-01). "Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti ... Cyclooxygenase (COX) and Phospholipase A2 are the major enzymes involved in prostaglandin production, and they are the drug ... Glucocorticoids work by inhibiting phospholipase A2, hence indirectly inhibiting prostaglandin synthesis. ...
https://en.wikipedia.org/wiki/Prostaglandin_inhibitors
Selective glucocorticoid receptor modulatorSelective glucocorticoid receptor modulator
Examples of glucocorticoid-responsive genes include those that encode annexin A1, TSC22D3 (also known as GILZ), angiotensin- ... These target genes encode proteins such as cyclooxygenase, NO synthase, phospholipase A2, tumor necrosis factor, transforming ...
https://en.wikipedia.org/wiki/Selective_glucocorticoid_receptor_modulator
A3A3
... a human gene Annexin A3, a human gene ATC code A03 Drugs for functional gastrointestinal disorders, a subgroup of the ... a document given to employees of A-1 and A-2 Visa Holders who are representing a foreign government inside the U.S. A3, the ...
https://en.wikipedia.org/wiki/A3
Specialized pro-resolving mediatorsSpecialized pro-resolving mediators
... annexin A1 (an inhibitor of formation of pro-inflammatory metabolites of polyunsaturated fatty acids), and the gaseous ... 6-epoxyisoprostane A2. Both PGJ2's are arachidonic acid-derived metabolites made by cyclooxygenases, primarily COX-2, which is ...
https://en.wikipedia.org/wiki/Specialized_pro-resolving_mediators
Annexin A4Annexin A4
... and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in ... Annexin A4 is a protein that in humans is encoded by the ANXA4 gene. Annexin IV (ANX4) belongs to the annexin family of calcium ... "Entrez Gene: ANXA4 annexin A4". Human ANXA4 genome location and ANXA4 gene details page in the UCSC Genome Browser. Römisch J, ... Dreier R, Schmid KW, Gerke V, Riehemann K (Aug 1998). "Differential expression of annexins I, II and IV in human tissues: an ...
https://en.wikipedia.org/wiki/Annexin_A4
Peripheral membrane proteinPeripheral membrane protein
"Pfam entry: Annexin". Archived from the original on 2007-09-29. Retrieved 2007-01-25. "Pfam entry Synapsin N". Archived from ... "Pfam entry: Phospholipase A2". Archived from the original on 2007-09-29. Retrieved 2007-01-25. "Pfam entry: ... The formation of ionic bridges is seen in the protein-lipid interaction between both protein C2 type domains and annexins.. Any ... They may also occur in BcL-2 like protein , in some amphiphilic antimicrobial peptides , and in certain annexins . These ...
https://en.wikipedia.org/wiki/Peripheral_membrane_protein
ANXA8L2ANXA8L2
Annexin A8-like protein 2 is a protein that in humans is encoded by the ANXA8L2 gene. This gene encodes a member of the annexin ... a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning ... "Entrez Gene: ANXA8 annexin A8". Human ANXA8 genome location and ANXA8 gene details page in the UCSC Genome Browser. Human ... 2006). "Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer". Clin. ...
https://en.wikipedia.org/wiki/ANXA8L2
ANXA2P3 annexin A2 pseudogene 3 [Homo sapiens (human)] - Gene - NCBIANXA2P3 annexin A2 pseudogene 3 [Homo sapiens (human)] - Gene - NCBI
Role of the long non‑coding RNA‑Annexin A2 pseudogene 3/Annexin A2 signaling pathway in biliary atresia‑associated hepatic ... Title: Role of the long non‑coding RNA‑Annexin A2 pseudogene 3/Annexin A2 signaling pathway in biliary atresia‑associated ... annexin A2 pseudogene 3provided by HGNC. Primary source. HGNC:HGNC:540 See related. AllianceGenome:HGNC:540 Gene type. pseudo. ... ANXA2P3 annexin A2 pseudogene 3 [ Homo sapiens (human) ] Gene ID: 305, updated on 13-May-2022 ...
https://www.ncbi.nlm.nih.gov/gene/305
JCI - Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophilsJCI - Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils
Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils. ... Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils. ...
https://www.jci.org/articles/view/153643/figure/7
Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 ( ANXA2 ) gene - Research RepositoryIdentifying low density lipoprotein cholesterol associated variants in the Annexin A2 ( ANXA2 ) gene - Research Repository
Background and aims Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). The ... Annexin A2; Proprotein convertase subtilisin/kexin type-9; Low-density lipoprotein cholesterol-receptor; Low-density ... Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 ( ANXA2 ) gene ... Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 ( ANXA2 ) gene. Atherosclerosis, 261. pp ...
http://repository.essex.ac.uk/19476/
Frontiers | Therapeutic Potential of Annexins in Sepsis and COVID-19Frontiers | Therapeutic Potential of Annexins in Sepsis and COVID-19
Human annexins play important roles in cell membrane dynamics, as well as mediation of systemic effects. Most notably, annexins ... Human annexins play important roles in cell membrane dynamics, as well as mediation of systemic effects. Most notably, annexins ... The mechanisms of action and demonstrated efficacy of annexins in animal models support development of annexins and their ... In numerous studies, treatment with recombinant human annexins and annexin analogue peptides have consistently found positive ...
https://www.frontiersin.org/articles/10.3389/fphar.2021.735472/full
Annexin A2 (C-terminal region) Antibody - ECM BiosciencesAnnexin A2 (C-terminal region) Antibody - ECM Biosciences
Annexin A1-13). These proteins are characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent ... The Annexin family of calcium-binding proteins is composed of al least thirteen mammalian genes ( ... Clone (M298) was generated from a recombinant sequence that included amino acids in the C-terminal region of rat Annexin A2. * ... Annexin A2 (C-terminal region) Antibody. Mouse Monoclonal. Application / Dilution ELISA. 1:2000. ...
https://ecmbio.com/collections/antibodies/products/am2981
Prognostic features of Annexin A2 expression in prostate cancer. | Pathology;53(2): 205-213, 2021 Feb. | MEDLINEPrognostic features of Annexin A2 expression in prostate cancer. | Pathology;53(2): 205-213, 2021 Feb. | MEDLINE
Prognostic features of Annexin A2 expression in prostate cancer. Prognostic features of Annexin A2 expression in prostate ... ANXA2 (Annexin A2 or Annexin II) is a calcium dependent phospholipid binding protein with diverse cellular functions. While ... Anexina A2; Prognóstico; Neoplasias da Próstata; Anexina A2/análise; Anexina A2/metabolismo; Biomarcadores Tumorais/análise; ... Anexina A2 Tipo de estudo: Estudo prognóstico Limite: Humanos / Masculino / Meia-Idade Idioma: Inglês Revista: Pathology Ano de ...
https://pesquisa.bvsalud.org/portal/resource/pt/mdl-32967771
The Tumorigenic Roles of the Cellular REDOX Regulatory SystemsThe Tumorigenic Roles of the Cellular REDOX Regulatory Systems
3.9.1. Annexin A2. Annexin A2 belongs to the family of annexins, which are commonly described as calcium-dependent phospholipid ... Oxidized annexin A2 is then recycled/reduced by the Trx system. Thus one molecule of annexin A2 has the ability to degrade ... "Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage," PLoS ONE, vol. 7 ... expressing normal levels of annexin A2). However, the growth impairment of the annexin A2-depleted tumors was rescued by the ...
https://www.hindawi.com/journals/omcl/2016/8413032/
Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies -...
Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. ... Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies ...
https://experts.unthsc.edu/en/publications/inhibition-of-triple-negative-and-herceptin-resistant-breast-canc/fingerprints/
Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies...Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 antibodies...
Annexin A2 (ANXA2) is a pro-metastasis protein, previously identified as a relevant PDAC antigen that is expressed by a GM-CSF- ... a Schematic diagram of the LADD strain with the Annexin A2 expression cassette. b Western blot analysis of DC2.4 cells infected ... From: Anti-pancreatic tumor efficacy of a Listeria-based, Annexin A2-targeting immunotherapy in combination with anti-PD-1 ...
https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0601-5/figures/1
Human Annexins A1, A2, and A8 as Potential Molecular Targets for Ni(II) Ions - IBB PAS RepositoryHuman Annexins A1, A2, and A8 as Potential Molecular Targets for Ni(II) Ions - IBB PAS Repository
... from annexin A1, Ac-KMSTVHEIL-am (A2-1) and Ac-SALSGHLET-am (A2-2), from annexin A2, and Ac-VKSSSHFNP-am (A8-1), from annexin ... Human Annexins A1, A2, and A8 as Potential Molecular Targets for Ni(II) Ions. (deposited 03 Nov 2014 09:15) * Human Annexins A1 ... Human annexins A1, A2, and A8, proteins modulating the immune system, contain several such sequences. To test if these proteins ... Human Annexins A1, A2, and A8 as Potential Molecular Targets for Ni(II) Ions ...
http://eprints.ibb.waw.pl/874/
Pathogenesis of bone disease in multiple myeloma: from bench to bedside | Blood Cancer JournalPathogenesis of bone disease in multiple myeloma: from bench to bedside | Blood Cancer Journal
Annexin II. Annexin II (Annexin A2) is a calcium-dependent phospholipid-binding member of the annexin family and is expressed ... Clinical and prognostic role of annexin A2 in multiple myeloma. Blood 120, 1087-1094 (2012). ... In the clinical setting, elevated annexin II expression is associated with adverse prognostic features61. Annexin II ... Annexin II is upregulated in MM patients and in MM cell lines and stimulates MM cell adhesion and growth, angiogenesis, ...
https://www.nature.com/articles/s41408-017-0037-4?error=cookies_not_supported
Cerebral Venous Thrombosis: Background, Etiology, EpidemiologyCerebral Venous Thrombosis: Background, Etiology, Epidemiology
Antibodies against the fibrinolytic receptor, annexin A2 (titer ,3 standard deviations), are significantly associated with CVT. ... annexin A2, in cerebral venous thrombosis. Stroke. 2011 Feb. 42(2):501-3. [QxMD MEDLINE Link]. ...
https://www.medscape.com/answers/1162804-41818/what-is-the-global-incidence-of-cerebral-venous-thrombosis-cvt
Tissue expression of PRKCH - Summary - The Human Protein AtlasTissue expression of PRKCH - Summary - The Human Protein Atlas
Annexin A2 receptor. 0.8526. 66. RFTN1. Raftlin, lipid raft linker 1. 0.8509. 16. ...
http://www.proteinatlas.org/ENSG00000027075-PRKCH/tissue
proteomics<...proteomics<...
We recently identified Annexin A2 as a molecule involved in metastases.. The analysis of antitumor immune responses in patients ...
https://www.hopkinsmedicine.org/research/research_lab_results.html?query=proteomics&pagesize=10&page=1
2009 - Biochemistry Department - UNIGE2009 - Biochemistry Department - UNIGE
Morel, Etienne; Gruenberg, Jean (2009) Annexin A2 Binding to Endosomes and Functions in Endosomal Transport Are Regulated by ... Morel, Etienne; Parton, Robert G.; Gruenberg, Jean (2009) Annexin A2-Dependent Polymerization of Actin Mediates Endosome ...
https://www.unige.ch/sciences/biochimie/publications/2009/
Recombinant protein - for ELISA - Proteins | BioVendor Research and Diagnostics ProductsRecombinant protein - for ELISA - Proteins | BioVendor Research and Diagnostics Products
Annexin A2 Apolipoprotein A5 Apolipoprotein D ATPase Inhibitor Mitochondrial Beta-Microseminoprotein Betatrophin Brain Fatty ...
https://www.biovendor.com/proteins?type=Recombinant+protein&application=ELISA
The growth-regulated gene 1B6 is identified as the heavy chain of calpactin I<...
Annexin A2 Medicine & Life Sciences 100% * Growth Medicine & Life Sciences 34% * Serum Medicine & Life Sciences 30% ...
https://jhu.pure.elsevier.com/en/publications/the-growth-regulated-gene-1b6-is-identified-as-the-heavy-chain-of-5
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimers...Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's...
Annexin A2. APP:. Amyloid precursor protein. ASM:. Acid sphingomyelinase. AβO:. Amyloid beta oligomers ... c) Representative confocal images of ALIX, AnnexinA2 (ANXA2), CD63, Flotillin1 (FLOT1) and RAB5 (red) in the CP of 7 weeks old ... AnnexinA2 (ANXA2), CD63, Flotillin1 (FLOT1) and RAB5 (red) in the CP 6 h after the icv injection of scrambled peptide or AβO in ... anti-AnnexinA2 (ANXA2) (1:200; ab54771; Abcam) and anti-C3 (1:100; PA5-21349; Thermo Scientific). After a washing step, ...
https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-021-01245-z
Limb-Girdle Muscular Dystrophy Clinical Presentation: History, CausesLimb-Girdle Muscular Dystrophy Clinical Presentation: History, Causes
Some of these proteins include annexins A1 and A2 (phospholipid binding proteins), caveolin-3 (LGMD1C), calpain-3 (LGMD2A), the ...
http://emedicine.medscape.com/article/1170911-clinical
Snyder, Greg | University of Maryland School of MedicineSnyder, Greg | University of Maryland School of Medicine
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. ...
https://www.medschool.umaryland.edu/profiles/Snyder-Greg/
Novel treatments for lupus nephritis - Lupus ResearchNovel treatments for lupus nephritis - Lupus Research
We will develop antagonists of the annexin A2-factor H interaction in order to prevent complement activation by annexin A2, and ... The protein annexin A2 is specifically expressed within the glomeruli of patients and mice with lupus nephritis, and we have ... Because annexin A2 expression within the glomerulus is specific for active lupus nephritis, antagonists of this interaction ... We hypothesize, therefore, that annexin A2 is a critical factor in the development of renal inflammation and injury in patients ...
https://www.lupusresearch.org/for-researchers/funded-research/grant/novel-treatments-for-lupus-nephritis/
Cureus | A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence...Cureus | A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence...
Kesavan K, Ratliff J, Johnson EW, Dahlberg W, Asara JM, Misra P, Frangioni JV, Jacoby DB: Annexin A2 is a molecular target for ... although recent evidence suggests a role for Annexin A2 [42]. In a clinical study, a radiolabeled synthetic version of ...
https://www.cureus.com/articles/2635-a-bioengineered-peptide-that-localizes-to-and-illuminates-medulloblastoma-a-new-tool-with-potential-for-fluorescence-guided-surgical-resection
Find Research outputs - Taipei Medical University
Dendritic cells respond to nasopharygeal carcinoma cells through annexin A2-recognizing DC-SIGN. Chao, P-Z., Hsieh, M-S., Cheng ...
https://tmu.pure.elsevier.com/en/publications/?page=297&showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&improvedLayoutOrganisationUuid=
PROTILÁTKY- CANVAXPROTILÁTKY- CANVAX
Rabbit Anti-ANXA2 (Annexin A2), 100 ug 291,06 € s DPH. 264,60 € bez DPH ...
https://aloquence.eu/215-protilatky-canvax
Mechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. | Scholars@DukeMechanism of Fibronectin Binding to Human Trabecular Meshwork Exosomes and Its Modulation by Dexamethasone. | [email protected]
In this way, dexamethasone-treated explants released exosomes with a significant reduction in annexin A2 and A6 per exosome. ... with our observation that trabecular meshwork exosomes are enriched in the heparin/heparan sulfate binding annexins A2 and A6. ...
https://scholars.duke.edu/display/pub1157628
Kentaro Fujii - Research output - Okayama University
Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma. Onishi, M., Ichikawa, T., Kurozumi, K., Inoue, S ... Annexin A2-STAT3-Oncostatin M receptor axis drives phenotypic and mesenchymal changes in glioblastoma. Matsumoto, Y., Ichikawa ...
https://okayama.pure.elsevier.com/en/persons/kentaro-fujii/publications/?type=%2Fdk%2Fatira%2Fpure%2Fresearchoutput%2Fresearchoutputtypes%2Fcontributiontojournal%2Farticle
Human IFITM3 (Interferon-induced transmembrane protein 3) recombinant protein - Protein AlternativesHuman IFITM3 (Interferon-induced transmembrane protein 3) recombinant protein - Protein Alternatives
Human ANXA2 (Annexin A2) recombinant protein €97,00. - €3.230,00. SKU: PRO-50027 ...
https://proteinalternatives.com/producto/human-ifitm3-interferon-induced-transmembrane-protein-3-recombinant-protein/
Human papillomavirus proteins are found in peripheral blood and semen Cd20+ and Cd56+ cells during Hpv-16 semen infection | BMC...Human papillomavirus proteins are found in peripheral blood and semen Cd20+ and Cd56+ cells during Hpv-16 semen infection | BMC...
The S100A10 subunit of the annexin A2 heterotetramer facilitates L2-mediated human papillomavirus infection. PLoS One. 2012, 7 ... concerted interaction between virus-capside proteins and more than one receptor on cell surface like α6-integrin or annexin A2- ...
https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-13-593
DeCSDeCS
Annexine A2 Entry term(s):. Annexin A2, P90 Complex. Annexin II. Annexin II, P36. Annexin II, P90 Complex. Calpactin I. ... 2005; use ANNEXIN II 1993-2004; ANNEXIN II & CALPACTIN I were indexed under CALCIUM-BINDING PROTEINS 1984-1992, ANNEXIN A2 was ... Annexin A2 - Preferred Concept UI. M0026276. Scope note. A member of the annexin family that is a substrate for a tyrosine ... Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 ...
https://decs.bvsalud.org/en/ths/resource/?id=30843
Code System Concept
Annexin A2 Active Synonym false false 2537434014 Annexin II Active Synonym false false ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=413542001
AnxA2ProteinsLipocortin IIProteinCalpactinRecombinantReactivitySignaling pathwayPeptidesMoleculePrognosticPhospholipaseAntibodyCellularPathogenesisOverexpressionMonoclonalAnti-inflammatoryInflammationHumanEfficacyInvolveSymbolMechanismsExpressionDependentModelsActivationCells
AnxA26
  • Background and aims Annexin-A2 (AnxA2) is an endogenous inhibitor of proprotein convertase subtilisin/kexin type-9 (PCSK9). (essex.ac.uk)
  • ANXA2 ( Annexin A2 or Annexin II ) is a calcium dependent phospholipid binding protein with diverse cellular functions. (bvsalud.org)
  • Par contre, plusieurs mécanismes responsables de la régulation et la dégradation du complexe PCSK9-LDLR n'ont pas encore été complètement caractérisés comme la régulation par la protéine annexin A2 (AnxA2), un inhibiteur endogène de PCSK9. (usherbrooke.ca)
  • Annexin A2 (AnxA2) was reported as an endogenous extracellular inhibitor of PCSK9 activity upon cell-surface LDLR degradation and mechanisms of PCSK9's regulation by AnxA2. (usherbrooke.ca)
  • Annexin A2 (ANXA2), also named Annexin-2 or Lipocortin II, is a Ca2+ binding protein that is up-regulated in virally transformed cell lines and human tumors. (ptglab.com)
  • Annexin A2 (ANXA2) protein mainly functions in bone formation and bone resorption. (who.int)
Proteins4
  • Annexin A5 is a 36-kDa endogenous protein and part of a 12-member family of ubiquitously and constitutively expressed proteins, and possesses anticoagulant, anti-inflammatory and anti-apoptotic properties. (frontiersin.org)
  • The Annexin family of calcium-binding proteins is composed of al least thirteen mammalian genes (Annexin A1-13). (ecmbio.com)
  • our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein beta-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers. (ewmccall.com)
  • Product Background Annexin A1 is a member of the Ca+2- dependent phospholipid binding proteins that are localized on the cytosolic face of the plasma membrane. (qedbio.com)
Lipocortin II1
  • Annexin A2 (calpactin I, chromobindin 8, p36, Lipocortin II, PAP-IV, or Protein I) is a cytoskeletal calcium-dependent phospholipid binding protein, which has been shown to be a mediator of cortocosteroid activity, a substrate for serine/threonine kinases and growth regulated tyrosine kinases, and may play a role in secretion. (ecmbio.com)
Protein5
  • This antibody detects a 36 kDa* protein corresponding to the molecular mass of Annexin A2 on SDS-PAGE immunoblots of rat PC12 cells. (ecmbio.com)
  • The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. (umaryland.edu)
  • The protein annexin A2 is specifically expressed within the glomeruli of patients and mice with lupus nephritis, and we have generated preliminary data demonstrating that annexin A2 blocks factor H from regulating complement within the glomerulus. (lupusresearch.org)
  • A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). (bvsalud.org)
  • Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. (bvsalud.org)
Calpactin1
  • The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain. (bvsalud.org)
Recombinant4
  • In numerous studies, treatment with recombinant human annexins and annexin analogue peptides have consistently found positive outcomes in animal models of sepsis, myocardial infarction, and ischemia reperfusion injury. (frontiersin.org)
  • Safety and efficacy of recombinant human annexin A5 are currently being studied in clinical trials in sepsis and severe COVID-19 patients. (frontiersin.org)
  • Clone (M298) was generated from a recombinant sequence that included amino acids in the C-terminal region of rat Annexin A2. (ecmbio.com)
  • Description Recombinant Human Annexin A1 produced in E. coli is a single, non- glycosylated polypeptide chain containing 346 amino acids with a molecular weight of 38.7kDa. (qedbio.com)
Reactivity1
  • CL594-66344 targets Annexin A1 in IF, FC (Intra) applications and shows reactivity with human, mouse samples. (ptglab.com)
Signaling pathway1
  • Role of the long non‑coding RNA‑Annexin A2 pseudogene 3/Annexin A2 signaling pathway in biliary atresia‑associated hepatic injury. (nih.gov)
Peptides1
  • These discoveries led to the development of analogous peptides which mimic their physiological function, and investigation into the potential of using the annexins and their analogous peptides as therapeutic agents in conditions where inflammation and coagulation play a large role in the pathophysiology. (frontiersin.org)
Molecule1
Prognostic2
  • Prognostic features of Annexin A2 expression in prostate cancer. (bvsalud.org)
  • Clinical and prognostic role of annexin A2 in multiple myeloma. (tu-freiberg.de)
Phospholipase3
  • It inhibits activity of phospholipase A2, binding 2-4 calcium ions with high affinity. (qedbio.com)
  • Given the involvement of phospholipase A2 in mediating inflammation, prostaglandins, and leukotrienes, Annexin A1 might have potential anti-inflammatory activity. (qedbio.com)
  • Role of oxygenated phosphatidylserine and its metabolites-lyso-phosphatidylserines produced after oxidation and hydrolysis by plasma lipoprotein-associated phospholipase A2 in clearance of apoptotic cells by macrophages: LC-ESI-MS study. (cdc.gov)
Antibody3
  • The blot was probed with mouse monoclonal anti-Annexin A2 antibody at 1:250 (lane 1) or 1:1000 (lane 2). (ecmbio.com)
  • The antibody has been shown to label Annexin A2 in immunocytochemical analysis of PC12 cells and immunohistochemical analysis of mouse diaphragm. (ecmbio.com)
  • Immunofluorescent analysis of (-20°C Methanol) fixed A549 cells using CoraLite®594 Annexin A1 antibody (CL594-66344, Clone: 1E1B7 ) at dilution of 1:200. (ptglab.com)
Cellular3
  • The Annexin family has been implicated as regulators of such diverse processes as ion-flux, endocytosis and exocytosis, and cellular adhesion. (ecmbio.com)
  • Altogether, our results indicate that human annexins A1, A2, and A8 are potential molecular targets for nickel toxicity and help design appropriate cellular studies. (waw.pl)
  • Role of annexin A2 in cellular entry of rabbit vesivirus. (ximbio.com)
Pathogenesis1
  • Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications. (cdc.gov)
Overexpression1
  • Annexin A6 reverses transformation of A431 cells after overexpression, and this effect may involve annexin A6 targeting of p120 RasGAP to the plasma membrane to inactivate Ras. (ecmbio.com)
Monoclonal1
  • The cells were fixed in paraformaldehyde and permeabilized using NP-40, then labeled with mouse monoclonal Annexin A2 (C-terminal region). (ecmbio.com)
Anti-inflammatory1
  • Most notably, annexins are highly involved in anti-inflammatory processes, adaptive immunity, modulation of coagulation and fibrinolysis, as well as protective shielding of cells from phagocytosis. (frontiersin.org)
Inflammation2
  • The effects of annexin A5 on inflammation and platelet activation may be particularly beneficial in disease caused by SARS-CoV-2 infection. (frontiersin.org)
  • We hypothesize, therefore, that annexin A2 is a critical factor in the development of renal inflammation and injury in patients with lupus. (lupusresearch.org)
Human3
  • Human annexins play important roles in cell membrane dynamics, as well as mediation of systemic effects. (frontiersin.org)
  • Synthesized peptide derived from the Internal region of human Annexin II. (afgsci.com)
  • 1X10^6 K-562 cells were intracellularly stained with 0.4 ug CoraLite®594 Anti-Human Annexin A1 (CL594-66344, Clone:1E1B7) (red), or 0.4 ug Mouse IgG1 Isotype Control (CL594-66360, Clone: T1F8D3F10) (blue). (ptglab.com)
Efficacy2
  • Annexins are molecules that show efficacy in preclinical models of sepsis but have not been investigated as a potential therapy in patients with sepsis. (frontiersin.org)
  • The mechanisms of action and demonstrated efficacy of annexins in animal models support development of annexins and their analogues for the treatment of sepsis. (frontiersin.org)
Involve1
  • Heat-stress response may also involve Annexin-2. (ptglab.com)
Symbol1
Mechanisms1
  • models for annexin A2-mediated vesicle aggregation mechanisms. (ewmccall.com)
Expression2
  • a Schematic diagram of the LADD strain with the Annexin A2 expression cassette. (biomedcentral.com)
  • Because annexin A2 expression within the glomerulus is specific for active lupus nephritis, antagonists of this interaction will have minimal effect in patients with quiescent disease. (lupusresearch.org)
Dependent2
  • Further, we found that exosome-fibronectin binding is heparan sulfate-dependent, consistent with our observation that trabecular meshwork exosomes are enriched in the heparin/heparan sulfate binding annexins A2 and A6. (duke.edu)
  • Annexin A2 regulates TRPA1-dependent nociception. (mpg.de)
Models1
  • Annexins A1 and A5 improve organ function and reduce mortality in animal sepsis models, inhibit inflammatory processes, reduce inflammatory mediator release, and protect against ischemic injury. (frontiersin.org)
Activation1
  • We will develop antagonists of the annexin A2-factor H interaction in order to prevent complement activation by annexin A2, and will test these agents in a model of lupus nephritis. (lupusresearch.org)
Cells3
  • Immunocytochemical labeling of Annexin A2 in NGF-differentiated rat PC12 cells. (ecmbio.com)
  • Annexin II is thought to serve as a profibrinolytic coreceptor for both plasminogen and tissue plasminogen activator on the surface of endothelial cells. (ximbio.com)
  • We found that phagocytosis of LA-enriched apoptotic HL60 cells (100 microM H2O2) by RAW 264.7 macrophages was significantly higher compared to naive apoptotic HL60 cells and was suppressed by annexin V. Using oxidative lipidomics approach we were able to detect the presence of oxidized PS species containing LA with two and three oxygens in LA-enriched apoptotic HL60 cells. (cdc.gov)
Frontiers | Therapeutic Potential of Annexins in Sepsis and COVID-19
Frontiers | Therapeutic Potential of Annexins in Sepsis and COVID-19 (frontiersin.org)
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems (hindawi.com)
Unexplained post-acute infection syndromes | Nature Medicine
Unexplained post-acute infection syndromes | Nature Medicine (nature.com)
Cerebral Venous Thrombosis: Background, Etiology, Epidemiology
Cerebral Venous Thrombosis: Background, Etiology, Epidemiology (medscape.com)
JCI - Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils
JCI - Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils (jci.org)
2009 - Biochemistry Department - UNIGE
2009 - Biochemistry Department - UNIGE (unige.ch)
Cerebral Venous Thrombosis Workup: Approach Considerations, Procedures, D-Dimer Levels
Cerebral Venous Thrombosis Workup: Approach Considerations, Procedures, D-Dimer Levels (medscape.com)
Limb-Girdle Muscular Dystrophy Clinical Presentation: History, Causes
Limb-Girdle Muscular Dystrophy Clinical Presentation: History, Causes (medscape.com)
Limb-Girdle Muscular Dystrophy Clinical Presentation: History, Causes
Limb-Girdle Muscular Dystrophy Clinical Presentation: History, Causes (medscape.com)
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's...
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's... (actaneurocomms.biomedcentral.com)
Novel treatments for lupus nephritis - Lupus Research
Novel treatments for lupus nephritis - Lupus Research (lupusresearch.org)
Cureus | A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence...
Cureus | A Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence... (cureus.com)
Kentaro Fujii - Research output - Okayama University
Kentaro Fujii - Research output - Okayama University (okayama.pure.elsevier.com)
Human papillomavirus proteins are found in peripheral blood and semen Cd20+ and Cd56+ cells during Hpv-16 semen infection | BMC...
Human papillomavirus proteins are found in peripheral blood and semen Cd20+ and Cd56+ cells during Hpv-16 semen infection | BMC... (bmcinfectdis.biomedcentral.com)
Publikationen | Max-Planck-Institut für Multidisziplinäre Naturwissenschaften
Publikationen | Max-Planck-Institut für Multidisziplinäre Naturwissenschaften (mpinat.mpg.de)
Volume 6, Issue 1 | Oncotarget
Volume 6, Issue 1 | Oncotarget (oncotarget.com)
Gut and Liver
Gut and Liver (gutnliver.org)
ANXA2 Antibody<...
ANXA2 Antibody<... (afgsci.com)
Recombinant Human Annexin A1 - QED Bioscience Inc
Recombinant Human Annexin A1 - QED Bioscience Inc (qedbio.com)
IHCeasy ANXA2 Ready-To-Use IHC Kit KHC0396 | Proteintech
IHCeasy ANXA2 Ready-To-Use IHC Kit KHC0396 | Proteintech (ptglab.com)
Gain-of-Function Experiments: TheSARS-CoV-2/HIV-1 Story - Civilian Intelligence Network 3.0
Gain-of-Function Experiments: TheSARS-CoV-2/HIV-1 Story - Civilian Intelligence Network 3.0 (civilianintelligencenetwork.ca)
Download Scales And Hierarchies 2014
Download Scales And Hierarchies 2014 (cdseidel.de)
Molecular regulation of cartilage and bone mineralization<...
Molecular regulation of cartilage and bone mineralization<... (nyuscholars.nyu.edu)
Annexin A1 antibody (CL594-66344) | Proteintech
Annexin A1 antibody (CL594-66344) | Proteintech (ptglab.com)
Rabbit Anti-ANXA3 (Annexin A3)
Rabbit Anti-ANXA3 (Annexin A3) (weblanau.com)