Ankyrin Repeat
Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33-amino acids was discovered in ANKYRIN where it is involved in interaction with the anion exchanger (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE). Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via protein-protein interactions.
Ankyrins
A family of membrane-associated proteins responsible for the attachment of the cytoskeleton. Erythrocyte-related isoforms of ankyrin attach the SPECTRIN cytoskeleton to a transmembrane protein (ANION EXCHANGE PROTEIN 1, ERYTHROCYTE) in the erythrocyte plasma membrane. Brain-related isoforms of ankyrin also exist.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Repetitive Sequences, Nucleic Acid
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
Tankyrases
Trinucleotide Repeats
Repetitive Sequences, Amino Acid
Spectrin
A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.
Protein Binding
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
I-kappa B Proteins
Base Sequence
Tandem Repeat Sequences
Sequence Homology, Amino Acid
Fowlpox
Receptors, Notch
A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Receptor, Notch1
Models, Molecular
Repressor Proteins
Binding Sites
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Anion Exchange Protein 1, Erythrocyte
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Muscle Proteins
NF-kappa B p50 Subunit
Minisatellite Repeats
Tandem arrays of moderately repetitive, short (10-60 bases) DNA sequences which are found dispersed throughout the GENOME, at the ends of chromosomes (TELOMERES), and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit.
Membrane Proteins
Trinucleotide Repeat Expansion
An increased number of contiguous trinucleotide repeats in the DNA sequence from one generation to the next. The presence of these regions is associated with diseases such as FRAGILE X SYNDROME and MYOTONIC DYSTROPHY. Some CHROMOSOME FRAGILE SITES are composed of sequences where trinucleotide repeat expansion occurs.
Cloning, Molecular
Transient Receptor Potential Channels
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Nuclear Proteins
Mutation
Proto-Oncogene Proteins c-rel
Cellular DNA-binding proteins encoded by the rel gene (GENES, REL). They are expressed predominately in hematopoietic cells and may play a role in lymphocyte differentiation. Rel frequently combines with other related proteins (NF-KAPPA B, I-kappa B, relA) to form heterodimers that regulate transcription. Rearrangement or overexpression of c-rel can cause tumorigenesis.
Spherocytosis, Hereditary
DNA-Binding Proteins
Mirabilis
Transcription Factors
Protein Engineering
Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.
Carrier Proteins
Microsatellite Repeats
Recombinant Fusion Proteins
TRPV Cation Channels
Suppressor of Cytokine Signaling Proteins
Erythrocyte Membrane
Crystallography, X-Ray
Myxoma virus
Dinucleotide Repeats
Genome
Molecular Sequence Annotation
The ankyrin repeat-containing adaptor protein Tvl-1 is a novel substrate and regulator of Raf-1. (1/285)
Tvl-1 is a 269-amino acid ankyrin repeat protein expressed primarily in thymus, lung, and testes that was identified by screening a murine T-cell two-hybrid cDNA library for proteins that associate with the serine-threonine kinase Raf-1. The interaction of Tvl-1 with Raf-1 was confirmed by co-immunoprecipitation of the two proteins from COS-1 cells transiently transfected with Tvl-1 and Raf-1 expression constructs as well as by co-immunoprecipitation of the endogenous proteins from CV-1 and NB2 cells. Tvl-1 interacts with Raf-1 via its carboxyl-terminal ankyrin repeat domain. The same domain also mediates Tvl-1 homodimerization. Tvl-1 was detected by immunofluorescence in both the cytoplasm and the nucleus suggesting that in addition to Raf-1 it may also interact with nuclear proteins. Activated Raf-1 phosphorylates Tvl-1 both in vitro and in vivo. In baculovirus-infected Sf9 insect cells, Tvl-1 potentiates the activation of Raf-1 by Src and Ras while in COS-1 cells it potentiates the activation of Raf-1 by EGF. These data suggest that Tvl-1 is both a target as well as a regulator of Raf-1. The human homologue of Tvl-1 maps to chromosome 19p12, upstream of MEF2B with the two genes in a head to head arrangement. (+info)Improved sensitivity of PCR for diagnosis of human granulocytic ehrlichiosis using epank1 genes of Ehrlichia phagocytophila-group ehrlichiae. (2/285)
The agent of human granulocytic ehrlichiosis (HGE), Ehrlichia phagocytophila, and Ehrlichia equi probably comprise variants of a single Ehrlichia species now called the Ehrlichia phagocytophila genogroup. These variants share a unique 153-kDa protein antigen with ankyrin repeat motifs encoded by the epank1 gene. The epank1 gene was investigated as an improved target for PCR diagnosis of HGE compared with the currently used 16S rRNA gene target. Primers for epank1 flanking a region that spans part of the 5' ankyrin repeat coding region and part of the unique 3' region were synthesized. Blood samples from 31 patients with suspected HGE who were previously tested by 16S rRNA gene (16S) PCR and indirect immunofluorescent antibody test (IFA) were retrospectively tested with the epank1 primers. Eleven patients were 16S PCR positive and had a seroconversion detected by IFA (group A), 10 patients were 16S PCR negative but had a seroconversion detected by IFA (group B), and 10 patients were 16S PCR negative and seronegative (group C). Ten of the 11 group A patients were epank1 PCR positive, all 10 of the group B patients were epank1 PCR positive, and all of the PCR-negative and seronegative patients (group C) were epank1 PCR negative. The epank1 primers are more sensitive than the previously used 16S rRNA gene primers and therefore may be more useful in diagnostic testing for HGE. (+info)Alastrim smallpox variola minor virus genome DNA sequences. (3/285)
Alastrim variola minor virus, which causes mild smallpox, was first recognized in Florida and South America in the late 19th century. Genome linear double-stranded DNA sequences (186,986 bp) of the alastrim virus Garcia-1966, a laboratory reference strain from an outbreak associated with 0.8% case fatalities in Brazil in 1966, were determined except for a 530-bp fragment of hairpin-loop sequences at each terminus. The DNA sequences (EMBL Accession No. Y16780) showed 206 potential open reading frames for proteins containing >/=60 amino acids. The amino acid sequences of the putative proteins were compared with those reported for vaccinia virus strain Copenhagen and the Asian variola major strains India-1967 and Bangladesh-1975. About one-third of the alastrim viral proteins were 100% identical to correlates in the variola major strains and the remainder were >/=95% identical. Compared with variola major virus DNA, alastrim virus DNA has additional segments of 898 and 627 bp, respectively, within the left and right terminal regions. The former segment aligns well with sequences in other orthopoxviruses, particularly cowpox and vaccinia viruses, and the latter is apparently alastrim-specific. (+info)SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. (4/285)
Notch proteins are transmembrane receptors that mediate intercell communication and direct individual cell fate decisions. The activated intracellular form of Notch, NotchIC, translocates to the nucleus, where it targets the DNA binding protein CBF1. CBF1 mediates transcriptional repression through the recruitment of an SMRT-histone deacetylase-containing corepressor complex. We have examined the mechanism whereby NotchIC overcomes CBF1-mediated transcriptional repression. We identified SKIP (Ski-interacting protein) as a CBF1 binding protein in a yeast two-hybrid screen. Both CBF1 and SKIP are highly conserved evolutionarily, and the SKIP-CBF1 interaction is also conserved in assays using the Caenorhabditis elegans and Drosophila melanogaster SKIP homologs. Protein-protein interaction assays demonstrated interaction between SKIP and the corepressor SMRT. More surprisingly, SKIP also interacted with NotchIC. The SMRT and NotchIC interactions were mutually exclusive. In competition binding experiments SMRT displaced NotchIC from CBF1 and from SKIP. Contact with SKIP is required for biological activity of NotchIC. A mutation in the fourth ankyrin repeat that abolished Notch signal transduction did not affect interaction with CBF1 but abolished interaction with SKIP. Further, NotchIC was unable to block muscle cell differentiation in myoblasts expressing antisense SKIP. The results suggest a model in which NotchIC activates responsive promoters by competing with the SMRT-corepressor complex for contacts on both CBF1 and SKIP. (+info)Analysis of notch lacking the carboxyl terminus identified in Drosophila embryos. (5/285)
The cell surface receptor Notch is required during development of Drosophila melanogaster for differentiation of numerous tissues. Notch is often required for specification of precursor cells by lateral inhibition and subsequently for differentiation of tissues from these precursor cells. We report here that certain embryonic cells and tissues that develop after lateral inhibition, like the connectives and commissures of the central nervous system, are enriched for a form of Notch not recognized by antibodies made against the intracellular region carboxy-terminal of the CDC10/Ankyrin repeats. Western blotting and immunoprecipitation analyses show that Notch molecules lacking this region are produced during embryogenesis and form protein complexes with the ligand Delta. Experiments with cultured cells indicate that Delta promotes accumulation of a Notch intracellular fragment lacking the carboxyl terminus. Furthermore, Notch lacking the carboxyl terminus functions as a receptor for Delta. These results suggest that Notch activities during development include generation and activity of a truncated receptor we designate NDeltaCterm. (+info)Molecular cloning and characterization of SRAM, a novel insect rel/ankyrin-family protein present in nuclei. (6/285)
Previously, we purified a 59-kDa protein that binds to the kappaB motif of the Sarcophaga lectin gene. Here we report its cDNA cloning and some of its characteristics as a novel member of the Rel/Ankyrin-family. This protein, named SRAM, contained a Rel homology domain, a nuclear localization signal and 4 ankyrin repeats, but lacked the Ser-rich domain and PEST sequence that Relish contained. We found that SRAM was localized in the nuclei of NIH-Sape-4 cells, which are an embryonic cell line of Sarcophaga. The Sarcophaga lectin gene promoter containing tandem repeats of the kappaB motifs was activated in NIH-Sape-4 cells. In Drosophila mbn-2 cells, Dif alone activated this reporter gene and a cooperative effect was detected when SRAM and Dif were co-transfected, although SRAM alone did not activate it. This is the first report of a Rel/Ankyrin molecule that exists in the nuclei. (+info)The L1-type cell adhesion molecule neuroglian influences the stability of neural ankyrin in the Drosophila embryo but not its axonal localization. (7/285)
Ankyrins are linker proteins, which connect various membrane proteins, including members of the L1 family of neural cell adhesion molecules, with the submembranous actin-spectrin skeleton. Here we report the cloning and characterization of a second, novel Drosophila ankyrin gene (Dank2) that appears to be the result of a gene duplication event during arthropod evolution. The Drosophila L1-type protein neuroglian interacts with products from both Drosophila ankyrin genes. Whereas the previously described ankyrin gene is ubiquitously expressed during embryogenesis, the expression of Dank2 is restricted to the nervous system in the Drosophila embryo. The absence of neuroglian protein in a neuroglian null mutant line causes decreased levels of Dank2 protein in most neuronal cells. This suggests that neuroglian is important for the stability of Dank2 protein. However, neuroglian is not required for Dank2 axonal localization. In temperature-sensitive neuroglian mutants in which neuroglian protein is mislocated at the restrictive temperature to an intracellular location in the neuronal soma, Dank2 protein can still be detected along embryonic nerve tracts. (+info)Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter. (8/285)
CARP, a cardiac doxorubicin (adriamycin)-responsive protein, has been identified as a nuclear protein whose expression is downregulated in response to doxorubicin. In the present study, we tested the hypothesis that CARP serves as a reliable genetic marker of cardiac hypertrophy in vivo and in vitro. CARP expression was markedly increased in 3 distinct models of cardiac hypertrophy in rats: constriction of abdominal aorta, spontaneously hypertensive rats, and Dahl salt-sensitive rats. In addition, we found that CARP mRNA levels correlate very strongly with the brain natriuretic peptide mRNA levels in Dahl rats. Transient transfection assays into primary cultures of neonatal rat cardiac myocytes indicate that transcription from the CARP and brain natriuretic peptide promoters is stimulated by overexpression of p38 and Rac1, components of the stress-activated mitogen-activated protein kinase pathways. Mutation analysis and electrophoretic mobility shift assays indicated that the M-CAT element can serve as a binding site for nuclear factors, and this element is important for the induction of CARP promoter activity by p38 and Rac1. Thus, our data suggest that M-CAT element is responsible for the regulation of the CARP gene in response to the activation of stress-responsive mitogen-activated protein kinase pathways. Moreover, given that activation of these pathways is associated with cardiac hypertrophy, we propose that CARP represents a novel genetic marker of cardiac hypertrophy. (+info)
2020 - Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin
Structure and stability of the ankyrin domain of the Drosophila Notch receptor<...
Frontiers | Orientia tsutsugamushi ankyrin repeat-containing protein family members are Type 1 secretion system substrates that...
KLUEDO | The Ankyrin Repeat Domain Controls Presynaptic Localization of Drosophila Ankyrin2 and Is Essential for Synaptic...
KANK1 - KN motif and ankyrin repeat domain-containing protein 1 - Homo sapiens (Human) - KANK1 gene & protein
ANKRD24 - Ankyrin repeat domain-containing protein 24 - Homo sapiens (Human) - ANKRD24 gene & protein
Ankyrin repeat domain-containing protein 13A
Ankyrin repeat domain-containing protein 18A
The Role of Membrane-Bound Ankyrin-Repeat Protein ACD6 in Programmed Cell Death and Plant Defense | Science Signaling
Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C.
ANKRD1, the Gene Encoding Cardiac Ankyrin Repeat Protein, Is a Novel Dilated Cardiomyopathy Gene | JACC: Journal of the...
A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral...
RCSB PDB - Protein Feature View
- Ankyrin repeat domain-containing protein 17 - Q99NH0 (ANR17 MOUSE)
TCDB » SEARCH
Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging
Most recent papers with the keyword Belonging | Read by QxMD
Inhibition Of Vascular Leakage And Choroidal Neovascularization Using Vegf-inhibiting Darpins In Rodents | IOVS | ARVO Journals
The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin - Semantic...
Pig Ankyrin repeat and BTB/POZ dom... - E07A1786-192T B-Gene - Anti...
Site-Selective Enzymatic Labeling of Designed Ankyrin Repeat Proteins Using Protein Farnesyltransferase. - Zurich Open...
Analyses of Physcomitrella patens Ankyrin Repeat Proteins by Computational Approach
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.
Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases - Nuffield Department of Medicine
MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor...
Novel mutations in the sarcomeric protein myopalladin in patients with dilated cardiomyopathy - MDC Repository
Ankyrin Repeat (ANKRD Family) < Protein Interaction Domains and Motifs << Tertiary Structure of a Protein (Tertiary Protein...
ANKS6 elisa kit | Bovine Ankyrin repeat and SAM domain-containing protein 6 (ANKS6) ELISA Kit-NP 775822.3
ANKRD49 ankyrin repeat domain 49 [Homo sapiens (human)] - Gene - NCBI
ANKRD30A ankyrin repeat domain 30A [Homo sapiens (human)] - Gene - NCBI
Shank2 MGI Mouse Gene Detail - MGI:2671987 - SH3 and multiple ankyrin repeat domains 2
Bio2Vec
Atlas: SHANK2 (SH3 and multiple ankyrin repeat domains 2)
ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3)
Ankyrin Repeat and SOCS Box Containing 8 Recombinant Protein
AGAP4 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 ) Blocking Peptide (the C terminal of AGAP4)(100ug) by Aviva...
UACA elisa kit | Rat Uveal Autoantigen With Coiled-Coil Domains and Ankyrin Repeats Antibodies ELISA Kit
Gentaur Molecular :GenWay \ Ankyrin repeat and SOCS box-containing protein 3 isoform a variant - \ 10-288-22178F
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric...
PIKE-A (PIKE-activating gene differs from PIKE-S with the addition of a - Allosteric Inhibitors of the Eya2 Phosphatase
Mutagenetix > Incidental...
FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP ...
Gene Expression Literature Detail
ANKRD20A15P Gene - GeneCards | ANKRD20A15P Pseudogene
ANKRD53 Gene - GeneCards | ANR53 Protein | ANR53 Antibody
Ankyrin repeat domain 3 | definition of ankyrin repeat domain 3 by Medical dictionary
Gtf2ird1 (untagged) - Mouse general transcription factor II I repeat domain-containing 1 (Gtf2ird1), transcript variant 9, ...
Ankyrin Repeat - Medical Dictionary online-medical-dictionary.org
Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL
JCI -
Welcome
TumorPortal
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and...
Mutagenetix > Incidental...
Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin ® protein MP0250: a preclinical study |...
ANKRA2 Protein Human Recombinant | ANKRA Antigen | ProSpec
Tissue expression of RFXANK - Summary - The Human Protein Atlas
Recombinant Human RFXANK protein (ab167884) | Abcam
Konformationsänderungen von repeat Proteine... ID:15338
Cas 122398-33-8,ASB-14-4 | lookchem
INK4
They contain multiple ankyrin repeats. The INK4a/ARF/INK4b locus encodes three genes (p15INK4b, ARF, and p16INK4a) in a 35- ... P15 is also formed from four ankyrin repeat (AR) motifs. Expression of P15INK4b is induced by TGF-b indicating its role as a ... P16 is formed from four ankyrin repeat (AR) motifs that exhibit a helix-turn-helix conformation except that the first helix in ...
ANKRD1
"Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich ... "Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich ... Shen L, Chen C, Wei X, Li X, Luo G, Zhang J, Bin J, Huang X, Cao S, Li G, Liao Y (May 2015). "Overexpression of ankyrin repeat ... Song Y, Xu J, Li Y, Jia C, Ma X, Zhang L, Xie X, Zhang Y, Gao X, Zhang Y, Zhu D (2012). "Cardiac ankyrin repeat protein ...
ANKRD31
Ankyrin repeat domain 31 is a protein that in humans is encoded by the ANKRD31 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: Ankyrin repeat domain 31". Retrieved 2016-05-13. CS1 maint: discouraged parameter (link) v t e. ...
Polyphosphate kinase
NUC-2 contains several ankyrin repeats. Several members of this family are annotated as XPR1 proteins: the xenotropic and ...
ANKRD17
Ankyrin repeat domain-containing protein 17 is a protein that in humans is encoded by the ANKRD17 gene. This gene encodes a ... "Entrez Gene: ANKRD17 ankyrin repeat domain 17". Human ANKRD17 genome location and ANKRD17 gene details page in the UCSC Genome ... protein with ankyrin repeats, which are associated with protein-protein interactions. Studies in mice suggest that this protein ...
ANKRD25
KN motif and ankyrin repeat domain-containing protein 2 is a protein that in humans is encoded by the KANK2 gene. GRCh38: ... "Entrez Gene: ANKRD25 ankyrin repeat domain 25". Human KANK2 genome location and KANK2 gene details page in the UCSC Genome ... Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". ... 2007). "SIP, a novel ankyrin repeat containing protein, sequesters steroid receptor coactivators in the cytoplasm". EMBO J. 26 ...
ANKRD13C
Ankyrin repeat domain-containing protein 13C is a protein that in humans is encoded by the ANKRD13C gene. ANKRD13C is predicted ... "Entrez Gene: ANKRD13C ankyrin repeat domain 13C". Chatr-Aryamontri A, Oughtred R, Boucher L, Rust J, Chang C, Kolas NK, ...
ANKRD15
KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene. This gene ... "Entrez Gene: ANKRD15 ankyrin repeat domain 15". Human KANK1 genome location and KANK1 gene details page in the UCSC Genome ... Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R (Sep 2002). "A novel ankyrin repeat-containing gene (Kank) located at ... Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". ...
KRIT1
"Entrez Gene: KRIT1 KRIT1, ankyrin repeat containing". Pagenstecher A, Stahl S, Sure U, Felbor U (Mar 2009). "A two-hit ... a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22". Oncogene. 15 (9): 1043-9. doi:10.1038/sj.onc. ...
NRARP
NOTCH regulated ankyrin repeat protein is a protein that in humans is encoded by the NRARP gene. GRCh38: Ensembl release 89: ... Chu BF, Qin YY, Zhang SL, Quan ZW, Zhang MD, Bi JW (July 2016). "Downregulation of Notch-regulated Ankyrin Repeat Protein ... Imaoka T, Okutani T, Daino K, Iizuka D, Nishimura M, Shimada Y (May 2014). "Overexpression of NOTCH-regulated ankyrin repeat ... "Entrez Gene: NOTCH regulated ankyrin repeat protein". Retrieved 2018-04-27. ...
ANKRD23
This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like ... 2003), "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response ... Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene. ... "Entrez Gene: ANKRD23 ankyrin repeat domain 23". Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; ...
Molecular Partners
They are derived from natural ankyrin repeat proteins. Repeat proteins are among the most common classes of binding proteins in ... "Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat ... Plückthun, A (2015). "Designed ankyrin repeat proteins (DARPins): binding proteins for research, diagnostics, and therapy". ... "High-affinity binders selected from designed ankyrin repeat protein libraries". Nature Biotechnology. 22 (5): 575-582. doi: ...
TRANK1
Tetratricopeptide repeat and ankyrin repeat containing 1 is a protein that in humans is encoded by the TRANK1 gene. Through a ... "Entrez Gene: Tetratricopeptide repeat and ankyrin repeat containing 1". Mühleisen TW, Leber M, Schulze TG, Strohmaier J, ...
PRR32
Ankyrin repeat domain-1 was overexpressed in both groups. Underexpressed genes in both groups included myosin light chain ... This action was repeated a few more times and it seems that the PRR32 gene is only relevant in mammals. The google spreadsheet ... leucine-rich repeat kinase-2, follistatin, collagen type XIX alpha-1, ceramide kinase-like, sestrin-3 and CXorf64. No genes ... Validation analysis using RT-PCR confirmed the data for leucine-rich repeat kinase-2, follistatin, collagen type XIX alpha-1, ...
POTEB
These orthologs share a similarity with POTEB largely due to the presence of ankyrin repeats, suggesting that ankyrin domain- ... Its secondary structure is mainly five helical ankyrin repeat domains, which contain the TALHL motif. There is also one ... Mosavi LK, Cammett TJ, Desrosiers DC, Peng ZY (June 2004). "The ankyrin repeat as molecular architecture for protein ... "Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil ...
CLIP4
In addition, ankyrin repeats are known to mediate protein-protein interactions. Furthermore, CLIP1, a paralog of CLIP4 in ... In terms of conserved domains, the CLIP4 gene contains primarily ankyrin repeats and the eponymous CAP-Gly domains. The ... Li J, Mahajan A, Tsai MD (December 2006). "Ankyrin repeat: a unique motif mediating protein-protein interactions". Biochemistry ... Two CAP-Gly domains and numerous ankyrin repeats. The secondary structure of CLIP4 consists largely of random coil, with alpha ...
Trophosome
Ankyrin repeats were believe to assist in the protein-protein interactions. The ankyrin repeat proteins could interact directly ... Li J, Mahajan A, Tsai MD (December 2006). "Ankyrin repeat: a unique motif mediating protein-protein interactions". Biochemistry ...
ASB1
Ankyrin repeat and SOCS box protein 1 is a protein that is in humans, encoded by the ASB1 gene. The protein encoded by this ... gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence ... "Entrez Gene: ASB1 ankyrin repeat and SOCS box-containing 1". CS1 maint: discouraged parameter (link) Human ASB1 genome location ... 2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, ...
ASB3
Ankyrin repeat and SOCS box protein 3 is a protein that in humans is encoded by the ASB3 gene. The protein encoded by this gene ... is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and ... "Entrez Gene: ASB3 ankyrin repeat and SOCS box-containing 3". CS1 maint: discouraged parameter (link) Human ASB3 genome location ... Chung AS, Guan YJ, Yuan ZL, Albina JE, Chin YE (May 2005). "Ankyrin repeat and SOCS box 3 (ASB3) mediates ubiquitination and ...
ANKRD24
... is in the protein family that contains ankyrin-repeat domains. Ankyrin repeats are known for mediating protein-protein ... Ankyrin repeat domain-containing protein 24 is a protein in humans that is coded for by the ANKRD24 gene. The gene is also ... "ANKRD24 ankyrin repeat domain 24 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-05-09. "Gene Card ... "ANKRD24 ankyrin repeat domain 24 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-04-27. "EST ...
ANKRD27
Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene. GRCh38: Ensembl release ... "Entrez Gene: ANKRD27 ankyrin repeat domain 27 (VPS9 domain)". Human ANKRD27 genome location and ANKRD27 gene details page in ...
DARPin
... s correspond to the average size of natural ankyrin repeat protein domains. Proteins with fewer than three repeats (i.e ... Typically, DARPins comprise four or five repeats, of which the first (N-capping repeat) and last (C-capping repeat) serve to ... They are derived from natural ankyrin repeat proteins, one of the most common classes of binding proteins in nature, which are ... Mosavi, L. K.; Minor, D. L.; Peng, Z. -Y. (2002). "Consensus-derived structural determinants of the ankyrin repeat motif". ...
CLPB
Either the ankyrin repeats alone or the AAA+ domain were found to be insufficient to support disaggregation activity. With only ... Notably, the presence of ankyrin repeats replaced the first of two ATPase domains found in bacteria and fungi. Skd3 belongs to ... In humans, the presence of ankyrin repeats replaced the first of two ATPase domains found in bacteria and fungi, which might ... Mosavi LK, Cammett TJ, Desrosiers DC, Peng ZY (June 2004). "The ankyrin repeat as molecular architecture for protein ...
ANKRD2
Ankyrin Repeat, PEST sequence and Proline-rich region (ARPP), also known as Ankyrin repeat domain-containing protein 2 is a ... "Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich ... "Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich ... ANKRD2 has nine exons, four of which encode ankyrin repeats in the middle region of the protein, a PEST-like and Lysine-rich ...
ANKS4B
The gene is also known as HARP (Harmonin-interacting, ankyrin repeat-containing protein). Ankyrin repeats mediate protein- ... Ankyrin repeat and sterile alpha motif domain containing 4B is a protein that in humans is encoded by the ANKS4B gene. ... "Ankyrin repeat and sterile alpha motif domain containing 4B". Retrieved 2011-12-06. "Dysmorphology data for Anks4b". Wellcome ... ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues". Genes to Cells. 9 (10 ...
BARD1
The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats ( ... The BARD1 protein also contains three tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino ... "Crystal structure of the BARD1 ankyrin repeat domain and its functional consequences". The Journal of Biological Chemistry. 283 ...
ANKHD1
Ankyrin repeat and KH domain-containing protein 1 is a protein that in humans is encoded by the ANKHD1 gene. This gene encodes ... "Entrez Gene: ANKHD1 ankyrin repeat and KH domain containing 1". Human ANKHD1 genome location and ANKHD1 gene details page in ... Traina F, Favaro PM, Medina Sde S, Duarte Ada S, Winnischofer SM, Costa FF, Saad ST (Sep 2006). "ANKHD1, ankyrin repeat and KH ... a protein with multiple ankyrin repeat domains and a single KH domain. Co-transcription of this gene and the neighboring ...
TRPV
... subunits contain three to five N-terminal ankyrin repeats. TRPV proteins respond to the taste of garlic (allicin). TRPV1 ...
SHANK3
SH3 and multiple ankyrin repeat domains 3 (Shank3), also known as proline-rich synapse-associated protein 2 (ProSAP2), is a ... A rat model of SHANK3 was developed using zinc finger nucleases targeting exon 6 of the ankyrin (ANK) repeat domain. The ... The gene encodes a protein that contains 5 interaction domains or motifs including the ankyrin repeats domain (ANK), a src 3 ... "Entrez Gene: SHANK3 SH3 and multiple ankyrin repeat domains 3". Sheng M, Kim E (June 2000). "The Shank family of scaffold ...
SHANK1
SH3 and multiple ankyrin repeat domains protein 1 is a protein that in humans is encoded by the SHANK1 gene. SHANK1 has been ... "Entrez Gene: SHANK1 SH3 and multiple ankyrin repeat domains 1". Park E, Na M, Choi J, Kim S, Lee JR, Yoon J, Park D, Sheng M, ... Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. ... Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. ...
HIF1AN - Вікіпедія
ankyrin repeat binding. • zinc ion binding. • dioxygenase activity. • зв'язування з іоном металу. • NF-kappaB binding. • Notch ...
Red blood cell
Ankyrin-based macromolecular complex - proteins linking the bilayer to the membrane skeleton through the interaction of their ... In the absence of nuclear elimination, the accumulation of repeat sequences is constrained by the volume occupied by the ... cytoplasmic domains with Ankyrin. *Band 3 - also assembles various glycolytic enzymes, the presumptive CO2 transporter, and ...
Secretion
... which stands for ankyrin repeat domain-containing protein A. Additionally, T4SS coupling proteins are VirD4, which bind to ...
Myofilament
The filaments are organized into repeated subunits along the length of the myofibril. These subunits are called sarcomeres. ...
Ankyrin repeat domain 11
... is a protein that in humans is encoded by the ANKRD11 gene.[5] ... ANKRD11, ANCO-1, ANCO1, LZ16, T13, ankyrin repeat domain 11. External IDs. OMIM: 611192 MGI: 1924337 HomoloGene: 69134 ... This locus encodes an ankyrin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of ... "Characterization of transcriptional regulatory domains of ankyrin repeat cofactor-1". Biochem. Biophys. Res. Commun. 358 (4): ...
FAK
"Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling" ...
CDH1 (gene)
ankyrin binding. • gamma-catenin binding. • beta-catenin binding. • GTPase activating protein binding. • metal ion binding. • ... Yoon YM, Baek KH, Jeong SJ, Shin HJ, Ha GH, Jeon AH, Hwang SG, Chun JS, Lee CW (September 2004). "WD repeat-containing mitotic ... The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a ... It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular ...
Chromosome 3
TRANK1: encoding protein Tetratricopeptide repeat and ankyrin repeat containing 1. *TUSC2: tumor suppressor candidate 2 ...
TRPV
... subunits contain three to five N-terminal ankyrin repeats.[9] ...
MYH9
... heavy chains dimerize through the tail domain forming a long alpha-helical coiled-coil rod composed of typical heptad repeats. ...
TLN1
Sun N, Critchley DR, Paulin D, Li Z, Robson RM (May 2008). "Identification of a repeated domain within mammalian alpha-synemin ...
Charcot-Marie-Tooth disease
Low copy repeats. *Christina's World. References[edit]. *^ a b c Krajewski, K. M. (2000). "Neurological dysfunction and axonal ... Ankyrin: Long QT syndrome 4 *Hereditary spherocytosis 1. Catenin. *APC *Gardner's syndrome ...
Vinculina, a enciclopedia libre
"Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling" ...
RBPJ
Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch ... Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch ... interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): ... interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): ...
Dynein
One projection, the coiled-coil stalk, binds to and "walks" along the surface of the microtubule via a repeated cycle of ...
CDKN2C - ويكيبيديا
"Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and ...
Kromosomang 6 (tao), ang malayang ensiklopedya
HACE1: HECT domain and Ankyrin repeat containing, E3 ubiquitin protein ligase 1 (6q21) ...
ANK2
Further studies have shown that the beta-hairpin loops within the ankyrin repeat domain of ankyrin-B are required for the ... Ankyrin-B, also known as Ankyrin-2, is a protein which in humans is encoded by the ANK2 gene.[1][2] Ankyrin-B is ubiquitously ... Ankyrin-B is a member of the ankyrin family of proteins. ankyrin-1 has shown to be essential in normal function of erythrocytes ... and determines ankyrin-B activity.[1][7][8] The membrane-binding region of ankyrin-B is composed of 24 consecutive ankyrin ...
Transcription factor
... repeat region in which there is a simple relationship between the identity of two critical residues in sequential repeats and ... 4.1.1 Family: Rel/ankyrin; NF-kappaB. *4.1.2 Family: ankyrin only ...
Myosin
ATP hydrolysis within the myosin will cause it to bind to actin again to repeat the cycle. The combined effect of the myriad ...
RFXANK
Wang AH, Grégoire S, Zika E, Xiao L, Li CS, Li H, Wright KL, Ting JP, Yang XJ (Aug 2005). "Identification of the ankyrin repeat ... This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare ... Lin JH, Makris A, McMahon C, Bear SE, Patriotis C, Prasad VR, Brent R, Golemis EA, Tsichlis PN (May 1999). "The ankyrin repeat- ... "Analysis of ankyrin repeats reveals how a single point mutation in RFXANK results in bare lymphocyte syndrome". Molecular and ...
Cytokeratin
Into this repeated pattern, the first and fourth residues are hydrophobic and the charged residues show alternate positive and ... have been probed to associate also with the ankyrin and spectrin complex protein network that underlies the cell membrane.[ ... The α-helical domain has 310-150 amino acids and comprises four segments in which a seven-residue pattern repeats. ...
Microfilament
... and this mechanoenzymatic cycle is then repeated, starting this time on the other sub-filament growth site. ...
Category:Protein pages needing a picture
Ankyrin. *Ankyrin-G binding motif of KCNQ2-3. *Anosmin-1. *Anthrax toxin ... Calponin family repeat. *Calsequestrin. *Calsyntenin. *Cannabinoid receptor. *Carbamoyl phosphate synthase II. *Carbamoyl ...
TNNT3
AAH repeats that possess high affinity binding to transition metal ions Cu(II), Ni(II), Zn(II) and Co(II).[27] The Tx segment ...
SPTAN1
Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin". J. Biol. Chem. ... First, a cardiac-specific, 21 amino acid sequence insert in the 21st spectrin repeat, termed alpha II-cardi+, was identified as ... Thirdly, an insert of five amino acids in the fifteenth spectrin motif bears a highly antigenic epitope resembling an ankyrin- ... Secondly, another insert of 20 amino acids in the 10th spectrin repeat, termed SH3i+, contains protein kinase A and protein ...
ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene. This gene ... "Entrez Gene: ABTB1 ankyrin repeat and BTB (POZ) domain containing 1". Human ABTB1 genome location and ABTB1 gene details page ... Dai KS, Wei W, Liew CC (Sep 2000). "Molecular cloning and characterization of a novel human gene containing ankyrin repeat and ... encodes a protein with an ankyrin repeat region and two BTB/POZ domains, which are thought to be involved in protein-protein ...
Index of biochemistry articles
... tandem repeat sequence - taste bud - TATA box - tax gene product - taxonomy - telophase - Tertiary structure - tetrodotoxin - ... ankyrin - annexin II - antibiotic - antibody - apoenzyme - apolipoprotein - apoptosis - aquaporin - archaea - arginine - ... trinucleotide repeat - Triose - tropomyosin - troponin - Tryptophan - tubulin - tumor necrosis factors - tumor necrosis factor ... dinucleotide repeat - Diploid - Disaccharide - Dissociation constant - Disulfide bond - Disulfide bridge - DNA - DNA ...
Ankyrin repeat domain 11 - Wikipedia
Ankyrin repeat domain 11 is a protein that in humans is encoded by the ANKRD11 gene.[5] ... ANKRD11, ANCO-1, ANCO1, LZ16, T13, ankyrin repeat domain 11. External IDs. OMIM: 611192 MGI: 1924337 HomoloGene: 69134 ... This locus encodes an ankyrin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of ... "Characterization of transcriptional regulatory domains of ankyrin repeat cofactor-1". Biochem. Biophys. Res. Commun. 358 (4): ...
Ankyrin repeat (IPR002110) | InterPro | EMBL-EBI
Ankyrin repeat (IPR002110). Short name: Ankyrin_rpt Description. The ankyrin repeat is one of the most common protein-protein ... Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse ... Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?. Proteins 17 ... Consensus-derived structural determinants of the ankyrin repeat motif.. Proc. Natl. Acad. Sci. U.S.A. 99 16029-34 2002 ...
Ankyrin repeat-containing domain superfamily (IPR036770) | InterPro | EMBL-EBI
Ankyrin repeat and death domain-containing protein 1A/1B (IPR039194). *Ankyrin repeat domain-containing protein 60 (IPR039323) ... The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly ... Ankyrin repeat-containing domain superfamily (IPR036770). Short name: Ankyrin_rpt-contain_sf ... This entry represents the ankyrin repeat-containing domain. These domains contain multiple repeats of a beta(2)-alpha(2) motif ...
Ankyrin repeat - Wikipedia
Ankyrin repeats typically fold together to form a single, linear solenoid structure called ankyrin repeat domains. These ... designed ankyrin repeat protein), an engineered antibody mimetic based on the structure of ankyrin repeats PDB: 1N11; Michaely ... A specialized family of ankyrin proteins known as muscle ankyrin repeat proteins (MARPs) are involved with the repair and ... Ankyrin repeats, by contrast, contain very few such contacts (that is, they have a low contact order). Most studies have found ...
ANKRD49 ankyrin repeat domain 49 [Homo sapiens (human)] - Gene - NCBI
Ank_2; Ankyrin repeats (3 copies). pfam13637. Location:75 → 128. Ank_4; Ankyrin repeats (many copies). ... Ank_2; Ankyrin repeats (3 copies). pfam13637. Location:75 → 128. Ank_4; Ankyrin repeats (many copies). ... ANKRD49 ankyrin repeat domain 49 [Homo sapiens] ANKRD49 ankyrin repeat domain 49 [Homo sapiens]. Gene ID:54851 ... ankyrin repeat domain 49provided by HGNC. Primary source. HGNC:HGNC:25970 See related. Ensembl:ENSG00000168876 Gene type. ...
Ankyrin repeat domain 22 - Wikipedia
ANKRD30A ankyrin repeat domain 30A [Homo sapiens (human)] - Gene - NCBI
Ank_2; Ankyrin repeats (3 copies). pfam13637. Location:42 → 93. Ank_4; Ankyrin repeats (many copies). sd00045. Location:74 → ... Ank_4; Ankyrin repeats (many copies). pfam12796. Location:77 → 167. Ank_2; Ankyrin repeats (3 copies). pfam14915. Location:1104 ... Ank_2; Ankyrin repeats (3 copies). pfam13637. Location:42 → 93. Ank_4; Ankyrin repeats (many copies). pfam14915. Location:1251 ... ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ...
Analyses of Physcomitrella patens Ankyrin Repeat Proteins by Computational Approach
High-Resolution Crystallographic Analysis of AcrB Using Designed Ankyrin Repeat Proteins (DARPins) | SpringerLink
Tam H.K., Malviya V.N., Pos K.M. (2018) High-Resolution Crystallographic Analysis of AcrB Using Designed Ankyrin Repeat ... High-Resolution Crystallographic Analysis of AcrB Using Designed Ankyrin Repeat Proteins (DARPins). ... High-affinity binders selected from designed ankyrin repeat protein libraries. Nat Biotechnol 22:575-582CrossRefPubMedGoogle ... soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins. J Mol Biol 332:489-503CrossRef ...
Ankyrin repeat domain 12 ELISA Kits | Biocompare
Compare Ankyrin repeat domain 12 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, ... Ankyrin repeat domain 12 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting ... Your search returned 20 Ankyrin repeat domain 12 ELISA ELISA Kit across 6 suppliers. ... Easy to use, small volume, room temperature, enough reagents to use the repeating pipette. read more ...
Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase | Scientific...
... uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. A ... Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification. Structure 24, 1679-1692 ... The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of ... Tankyrase contains five N-terminal ankyrin repeat clusters (ARCs), four of which, namely ARCs 1, 2, 4 and 5, can recruit ...
Ankyrin Repeat - Medical Dictionary online-medical-dictionary.org
Ankyrin Repeat. Protein Motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating ... Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via protein-protein interactions. ... sequence of 33-Amino Acids was discovered in Ankyrin where it is involved in interaction with the anion exchanger (Anion ...
Ankyrin repeat domain 29 ELISA Kits | Biocompare.com
Compare Ankyrin repeat domain 29 ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, ... Ankyrin repeat domain 29 ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a well-established antibody-based tool ... Your search returned 13 Ankyrin repeat domain 29 ELISA ELISA Kit across 1 supplier. ...
Sequence Similarity
- 1SW6: S. CEREVISIAE SWI6 ANKYRIN-REPEAT FRAGMENT Sequence Similarity Report Page
ankrd46a - Ankyrin repeat domain 46a - Danio rerio (Zebrafish) - ankrd46a gene & protein
IPR002110, Ankyrin_rpt. IPR020683, Ankyrin_rpt-contain_dom. IPR036770, Ankyrin_rpt-contain_sf. ... IPR002110, Ankyrin_rpt. IPR020683, Ankyrin_rpt-contain_dom. IPR036770, Ankyrin_rpt-contain_sf. ... Ankyrin repeat domain 46aImported. ,p>Information which has been imported from another database using automatic procedures.,/p ... tr,E7F3W1,E7F3W1_DANRE Ankyrin repeat domain 46a OS=Danio rerio OX=7955 GN=ankrd46a PE=1 SV=1 ...
Ankyrin repeat | definition of ankyrin repeat by Medical dictionary
... ankyrin repeat explanation free. What is ankyrin repeat? Meaning of ankyrin repeat medical term. What does ankyrin repeat mean? ... Looking for online definition of ankyrin repeat in the Medical Dictionary? ... ankyrin repeat. Also found in: Wikipedia. ankyrin repeat. A short repetitive sequence of amino acids consisting of a beta ... The beta strands on adjacent ankyrin repeats combine to form a short antiparallel beta sheet. Ankyrin repeats were first ...
RCSB PDB - 4N5Q: Crystal structure of the N-terminal ankyrin repeat domain of TRPV3
... there is an ankyrin repeat domain (ARD) in their intracellular N-termini. Ankyrin (ANK) repeat, a common motif with typically ... there is an ankyrin repeat domain (ARD) in their intracellular N-termini. Ankyrin (ANK) repeat, a common motif with typically ... Here, we report the crystal structure of TRPV3-ARD solved at 1.95 Å resolution, which reveals six-ankyrin repeats. While ... Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for ...
TVAG 224290 - Ankyrin repeat protein, putative - Trichomonas vaginalis - TVAG 224290 gene & protein
IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR036770. Ankyrin_rpt-contain_sf. ... IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR036770. Ankyrin_rpt-contain_sf. ... Ankyrin repeat protein, putativeImported. ,p>Information which has been imported from another database using automatic ... tr,A2DW52,A2DW52_TRIVA Ankyrin repeat protein, putative OS=Trichomonas vaginalis GN=TVAG_224290 PE=4 SV=1 ...
Ankyrin Repeat Domain 33B Research Products: Novus Biologicals
Browse our Ankyrin Repeat Domain 33B product catalog backed by our Guarantee+. ... Ankyrin Repeat Domain 33B products available through Novus Biologicals. ... Bioinformatics Tool for Ankyrin Repeat Domain 33B. Discover related pathways, diseases and genes to Ankyrin Repeat Domain 33B. ... Ankyrin Repeat Domain 33B Antibodies (2). Ankyrin Repeat Domain 33B Protein (1) ...
Ankrd13c (ankyrin repeat domain 13c) - Rat Genome Database
Sus scrofa (pig) : ANKRD13C (ankyrin repeat domain 13C) Chlorocebus sabaeus (green monkey) : ANKRD13C (ankyrin repeat domain ... ankyrin repeat domain 13C) HGNC Alliance Rattus norvegicus (Norway rat) : Ankrd13c (ankyrin repeat domain 13C) Alliance ... ankyrin repeat domain 13C) Pan paniscus (bonobo/pygmy chimpanzee) : ANKRD13C (ankyrin repeat domain 13C) Canis lupus familiaris ... ankyrin repeat domain 13C) Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ankrd13c (ankyrin repeat domain 13C) ...
Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging
Shank2 MGI Mouse Gene Detail - MGI:2671987 - SH3 and multiple ankyrin repeat domains 2
Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein...
2). The two DARPins E40 and pE59 in the complex have the expected ankyrin repeat domain fold (Fig. 2 and Fig. 3A). The ... 2003) Designed to be stable: Crystal structure of a consensus ankyrin repeat protein. Proc Natl Acad Sci USA 100:1700-1705. ... 2010) Designed ankyrin repeat proteins: A novel tool for testing epidermal growth factor receptor 2 expression in breast cancer ... 2012) Designed Ankyrin Repeat Proteins (DARPins) as novel isoform-specific intracellular inhibitors of c-Jun N-terminal kinases ...
Ankrd2 (ankyrin repeat domain 2 (stretch responsive muscle)) - Rat Genome Database
Homo sapiens (human) : ANKRD2 (ankyrin repeat domain 2) HGNC Alliance Rattus norvegicus (Norway rat) : Ankrd2 (ankyrin repeat ... Pan paniscus (bonobo/pygmy chimpanzee) : ANKRD2 (ankyrin repeat domain 2) Canis lupus familiaris (dog) : ANKRD2 (ankyrin repeat ... ankyrin repeat domain-containing protein 2; Arpp; mArpp; skeletal muscle ankyrin repeat protein. ... ANKRD2 (ankyrin repeat domain 2). Transitive Ortholog Pipeline. Transitive Ortholog Pipeline. Canis lupus familiaris (dog):. ...
Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock | Science Signaling
We report that the ankyrin repeat domains of ANKRA2 and its close paralog regulatory factor X-associated ankyrin-containing ... the ankyrin repeat domain of ANKRA2 in complex with its binding peptides revealed that each of the middle three ankyrin repeats ... Ankyrin repeat family A protein 2 (ANKRA2) interacts with the plasma membrane receptor megalin and the class IIa histone ... Phosphorylation of a motif that binds to ankyrin repeat domains switches its binding preference to 14-3-3 proteins. ...
Tumor Targeting with Designed Ankyrin Repeat Proteins | Gebert Rüf Stiftung
Tumor Targeting with Designed Ankyrin Repeat Proteins GRS-054/04 CHF 241000 Michael Stumpp 07.2005 - 07.2008 ... Tumor Targeting with Designed Ankyrin Repeat Proteins. Rédaction. Für den Inhalt der Angaben zeichnet die Projektleitung ... In den letzten fünf Jahren wurden von uns "Designed Ankyrin Repeat Proteins" (DARPins) entwickelt, die eine neue Klasse von ... High-affinity binders selected from designed ankyrin repeat protein libraries. Nature Biotechnol. 22, 575-582. Zahnd C., ...
KRIT1, Ankyrin Repeat Containing ELISA & Assay Kits
Compare and order KRIT1, Ankyrin Repeat Containing ELISA Kits. View citations, images, detection ranges, sensitivity, prices ... More product categories related to KRIT1, Ankyrin Repeat Containing ELISA Kit * 49 anti-KRIT1, Ankyrin Repeat Containing ... KRIT1, Ankyrin Repeat Containing ELISA Kit. 4 products by 2 suppliers: Wuhan Fine biotech , Cloud-Clone ... This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY ...
Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein
... : Biological Overview , References Gene name - Ankyrin- ... Classification - Ankyrin-repeat, SH3-domain, and Proline-rich-region Cellular location - cytoplasmic ... dASPP is the homolog of mammalian ASPP1 and -2 (Ankyrin-repeat, SH3-domain and Proline-rich-region containing Protein). ASPP1 ... Drosophila Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (dASPP) has been identified as a regulator of ...
ANKS3 (ankyrin repeat and sterile alpha motif domain containing 3)
Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors | Science
A microbial protein containing ankyrin repeats is injected into host cells through a specialized secretion system where it ... A microbial protein containing ankyrin repeats is injected into host cells through a specialized secretion system where it ... Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors ... Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors ...
ProteinsGeneMotifHighly conservedContain ankyrin repeatsDesigned ankyrin repeat protein librariesSecond ankyrin repeatAminoDomainsCardiacEncodesTRPA1Protein-protein inteAsparagineCytoskeletal proteinSOCSMediateInteractionFoldSkeletal muscleIntracellularELISA ELISA KitKinaseTumorTRPCResiduesCytosolicDARPinTransientAntiparallel
Proteins60
- The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. (ebi.ac.uk)
- Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally? (ebi.ac.uk)
- The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. (wikipedia.org)
- Domains consisting of ankyrin tandem repeats mediate protein-protein interactions and are among the most common structural motifs in known proteins. (wikipedia.org)
- Ankyrin repeat proteins, though absent in most viruses, are common among poxviruses. (wikipedia.org)
- Most proteins that contain the motif have four to six repeats, although its namesake ankyrin contains 24, and the largest known number of repeats is 34, predicted in a protein expressed by Giardia lamblia. (wikipedia.org)
- A structure-based study involving a range of ankyrin proteins of known structures, shows that consensus-based ankyrin proteins are very stable since they maximize the energetic gap between the folding and unfolding structures, encoding a densely connected network of favourable interactions among conserved sequence motifs, like the TPLX motif. (wikipedia.org)
- Ankyrin-repeat proteins present an unusual problem in the study of protein folding, which has largely focused on globular proteins that form well-defined tertiary structure stabilized by long-range, nonlocal residue-residue contacts. (wikipedia.org)
- Some evidence, based on synthesis of truncated versions of natural repeat proteins, and on the examination of phi values, suggests that the C-terminus forms the folding nucleation site. (wikipedia.org)
- Ankyrin-repeat proteins have been associated with a number of human diseases. (wikipedia.org)
- These proteins include the cell cycle inhibitor p16, which is associated with cancer, and the Notch protein (a key component of cell signalling pathways) which can cause the neurological disorder CADASIL when the repeat domain is disrupted by mutations. (wikipedia.org)
- A specialized family of ankyrin proteins known as muscle ankyrin repeat proteins (MARPs) are involved with the repair and regeneration of muscle tissue following damage due to injury and stress. (wikipedia.org)
- Ankyrin (ANK) repeat containing proteins are evolutionary conserved and have functions in crucial cellular processes like cell cycle regulation and signal transduction. (hindawi.com)
- The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. (nature.com)
- Ankyrin repeats were first identified in ankyrin, which tethers different proteins (e.g., nuclear and cytoplasmic proteins), helping regulate gene expression and embryonic development. (thefreedictionary.com)
- The active ingredient, which comprises several DARPins (designed ankyrin repeat proteins), is also easy to produce. (thefreedictionary.com)
- The Z-disk proteins include [alpha]-actinin 2, cardiac ankyrin repeat protein, muscle LIM protein, LIM binding domain 3, myozenin 2, telethonin, and vinculin/metavinculin. (thefreedictionary.com)
- Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors," Journal of Virology 87(10): 5868-5881. (thefreedictionary.com)
- We have selected designed ankyrin repeat proteins (DARPins) from a synthetic library by using ribosome display that selectively bind to the mitogen-activated protein kinase ERK2 (extracellular signal-regulated kinase 2) in either its nonphosphorylated (inactive) or doubly phosphorylated (active) form. (pnas.org)
- In den letzten fünf Jahren wurden von uns "Designed Ankyrin Repeat Proteins" (DARPins) entwickelt, die eine neue Klasse von vielversprechenden Proteintherapeutika darstellen. (grstiftung.ch)
- Selection and Characterization of Her2 Binding-designed Ankyrin Repeat Proteins. (grstiftung.ch)
- We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. (sciencemag.org)
- Many bacterial pathogens and endosymbionts use TFSSs to regulate host processes important for survival and replication ( 2 ), and several of these organisms have a large number of genes encoding proteins with multiple ankyrin repeat homology domains (ARHDs) ( 3 - 7 ). (sciencemag.org)
- Many intracellular bacterial pathogens utilize the Type 1 (T1SS) or Type 4 secretion system (T4SS) to translocate ankyrin repeat-containing proteins (Anks) that traffic to distinct subcellular locations and modulate host cell processes. (frontiersin.org)
- We show here that with very small high-affinity proteins such as designed ankyrin repeat proteins (DARPins), these limits can be overcome. (aacrjournals.org)
- We show here that with very small high-affinity proteins such as designed ankyrin repeat proteins (DARPins), these limits can be overcome, and we present a systematic approach that establishes the observed tumor accumulation and targeting contrast as a function of affinity, targeting molecule size, and pharmacokinetics. (aacrjournals.org)
- Recently, we have developed combinatorial libraries of a new class of small proteins, termed "designed ankyrin repeat proteins" ( 19 , 20 ) that can act as an alternative to antibodies, as they are particularly robust to engineering. (aacrjournals.org)
- The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. (creative-biogene.com)
- Site-Selective Enzymatic Labeling of Designed Ankyrin Repeat Proteins Using Protein Farnesyltransferase. (uzh.ch)
- In this protocol, we present a detailed procedure for labeling Designed Ankyrin Repeat Proteins (DARPins) engineered with a C-terminal CVIA sequence using an azide-containing FPP analog by yeast PFTase (yPFTase). (uzh.ch)
- Designed ankyrin repeat proteins (DARPins) are engineered scaffold proteins with high potential as probes for radionuclide molecular imaging. (diva-portal.org)
- Recently, major species-specific antibody epitopes in three immunoreactive tandem repeat proteins (TRPs) of Ehrlichia chaffeensis , TRP32, TRP47, and TRP120, have been identified and molecularly characterized within tandem repeat (TR) regions. (asm.org)
- Nuclear import may be a conserved property of ankyrin repeat domains (ARDs), as the ARDs from two other ARD-containing proteins, 53BP2 and GABPbeta , are also able to function as nuclear import sequences. (caltech.edu)
- Single-channel electrophysiological recordings of heterologously expressed and purified Anopheles gambiae TRPA1 (AgTRPA1), with and without the N-terminal ankyrin repeat domain, demonstrate that both proteins are functional because they responded to the electrophilic compounds allyl isothiocyanate and cinnamaldehyde as well as heat. (lu.se)
- We have identified two Nicotiana plumbaginifolia ankyrin-repeat proteins, designated $$\underline{G}$$ lucanohydrolase $$\underline{B}$$ inding $$\underline{P}$$ roteins (GBP) 1 and 2, that bind GLU I and CHN I both in vitro and when expressed in yeast cells. (deepdyve.com)
- GBP1/2 are members of a conserved $$\underline{P}$$ lant-specific $$\underline{Ank}$$ yrin- repeat (PANK) family that includes proteins implicated in carbohydrate allocation, reactive oxygen metabolism, hypersensitive cell death, rapid elicitor responses, virus pathogenesis, and auxin signaling. (deepdyve.com)
- Ankyrin repeats (ARs) are one of the most common structural motifs among eukaryotic proteins. (ox.ac.uk)
- The ankyrin (ANK) repeat was named after the cytoskeletal protein ankyrin and is found in a wide range of eukaryotic and bacterial proteins where it mediates protein-protein interactions. (otago.ac.nz)
- Viruses, especially the Poxviridae and Polydnaviridae families, also encode ANK repeat containing proteins. (otago.ac.nz)
- ANK repeat proteins form the largest family of Chordopoxvirus proteins but knowledge of their functions remains limited. (otago.ac.nz)
- Consistent with this, some mammalian ANK repeat containing proteins have been shown to interact with FIH-1 and undergo asparaginyl hydroxylation. (otago.ac.nz)
- The role of asparaginyl hydroxylation of cellular ANK repeat proteins remains elusive but these observations raised the possibility that viral ANK repeat proteins might interact with FIH-1 in infected cells. (otago.ac.nz)
- Here it is demonstrated that the five orf virus (ORFV) ANK repeat proteins ov008, ov123, ov126, ov128, and ov129 interact with endogenous FIH-1. (otago.ac.nz)
- The results reveal a possible link between poxviral ANK repeat proteins and the HIF pathway. (otago.ac.nz)
- FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. (ox.ac.uk)
- Proteins containing a common interaction motif known as the ankyrin repeat domain (ARD) have been shown to be efficiently hydroxylated by FIH. (ox.ac.uk)
- Shank1-3 proteins (also called ProSAP, SSTRIP, cortBP, Synamon, and Spank) contain ankyrin repeats, an Src homology 3 (SH3) domain, a PSD-95-Discs Large-zona occludens-1 (PDZ) domain, a proline-rich domain, and a sterile alpha motif (SAM) domain. (jneurosci.org)
- The ankyrin (ANK) repeat genes encode for proteins characterized by the repetitive motifs in its amino acid sequence. (wmich.edu)
- Bacterial endosymbiont genes were identified in this dataset, some of which have a copy number consistent with being lateral gene transfers between endosymbiont genomes and Hemiptera, including ankyrin-repeat related proteins, lysozyme, and mannanase. (biomedcentral.com)
- In both proteins, the second ankyrin (ANK) repeat region and the β-hairpin loops connecting this repeat with the rest of the protein are significantly unfolded. (uconn.edu)
- Thus, p16C is the smallest ANK repeat module that can fold independently and the two ANK repeat fold may represent the minimum structural unit for all ANK repeat proteins. (uconn.edu)
- Other discoveries include the apparent inability of w Mel to synthesize lipopolysaccharide and the presence of the most genes encoding proteins with ankyrin repeat domains of any prokaryotic genome yet sequenced. (plos.org)
- Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. (ox.ac.uk)
- In support of this certain ankyrin repeat domain (ARD)-containing proteins, including members of the IkappaB and Notch families, have been identified as alternative substrates of the HIF asparaginyl hydroxylase factor inhibiting HIF (FIH). (ox.ac.uk)
- Overall the work has defined 13 new FIH-dependent hydroxylation sites with a degenerate consensus corresponding to that of the ankyrin repeat and a range of ARD-containing proteins as actual and potential substrates for FIH. (ox.ac.uk)
- 2009). AA: A truncated two-alpha-helix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex. (core.ac.uk)
- 2008). AA: Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. (core.ac.uk)
- 2005). F-box-like domains are present in most poxvirus ankyrin repeat proteins. (core.ac.uk)
- Nonantibody scaffolds such as designed ankyrin repeat proteins (DARPins) can be rapidly engineered to detect diverse target proteins with high specificity and offer an attractive alternative to antibodies. (elsevier.com)
- In addition to the hypoxia-inducible factor C-terminal transcriptional activation domain (HIF-CAD), FIH also catalyses asparaginyl hydroxylation of many ankyrin repeat domain-containing proteins, revealing a broad sequence selectivity. (ox.ac.uk)
Gene10
- Ankyrin repeat domain 11 is a protein that in humans is encoded by the ANKRD11 gene . (wikipedia.org)
- ANKRD1, the gene encoding cardiac ankyrin repeat protein, is a novel dilated cardiomyopathy gene. (thefreedictionary.com)
- This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. (mybiosource.com)
- Objectives We evaluated ankyrin repeat domain 1 ( ANKRD1) , the gene encoding cardiac ankyrin repeat protein (CARP), as a novel candidate gene for dilated cardiomyopathy (DCM) through mutation analysis of a cohort of familial or idiopathic DCM patients, based on the hypothesis that inherited dysfunction of mechanical stretch-based signaling is present in a subset of DCM patients. (onlinejacc.org)
- ANKRD34A (Ankyrin Repeat Domain 34A) is a Protein Coding gene. (genecards.org)
- The ANKRD11 gene provides instructions for making a protein called ankyrin repeat domain 11 (ANKRD11). (nih.gov)
- Suryawanshi, Yogesh, "Generation of Tanapoxvirus Ankyrin Repeat Gene Deletion Mutant for Evaluating its Role in Cell Tropism" (2012). (wmich.edu)
- This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. (gen-script.com)
- Here, we focus on MNF gene, which has been shown to express a nuclear protein presenting nine ANK repeats, one of which has been identified as a nuclear localization signal. (core.ac.uk)
- 2009). The orthopoxvirus 68-kilodalton ankyrin-like protein is essential for DNA replication and complete gene expression of modified vaccinia virus Ankara in nonpermissive human and murine cells. (core.ac.uk)
Motif8
- Consensus-derived structural determinants of the ankyrin repeat motif. (ebi.ac.uk)
- The ankyrin-repeat sequence motif has been studied using multiple sequence alignment to determine conserved amino acid residues critical for folding and stability. (wikipedia.org)
- These domains contain multiple repeats of a beta(2)-alpha(2) motif. (ebi.ac.uk)
- Source:RefSeq mRNA;Acc :NM_001109946] ENSSSCG00000005 607 RALGPS 1 Ral GEF with PH domain and SH3 binding motif 1 [Source:HGNC Symbol;Acc:16851] ENSSSCG00000005 679 ASB6 Sus scrofa ankyrin repeat and SOCS box containing 6 (ASB6), mRNA. (thefreedictionary.com)
- Ankyrin (ANK) repeat, a common motif with typically 33 residues in each repeat, is primarily involved in protein-protein interactions. (rcsb.org)
- Two GABPα/β heterodimers associate via the COOH-terminal residues of GABPβ, resulting in a heterotetramer that binds to DNA sequences containing two tandem repeats of the GGA motif ( 19 ). (sciencemag.org)
- p16 contains four ANK repeats, a 33-residue sequence motif that mediates protein-protein interactions. (uconn.edu)
- Because it contains several domains for protein-protein interactions, including ankyrin repeats, tetratricopeptide repeats (TPRs), a coiled-coil domain, and a C-terminal PDZ (PSD-95/Dlg/ZO-1) domain-binding motif, TANC1 is thought to function as a scaffold/adaptor protein. (jneurosci.org)
Highly conserved3
- C terminal to the RAM domain lie six interated ankyrin repeats (ANK) (amino acids 1860 to 2155), a highly conserved domain necessary for all known Notch functions ( 1 ). (asm.org)
- Recent analyses have shown that factor inhibiting hypoxia-inducible factor (FIH) catalyses the hydroxylation of highly conserved Asn-residues within ankyrin repeat domains (ARDs). (ox.ac.uk)
- 2008). The highly conserved orthopoxvirus 68k ankyrin-like protein is part of a cellular SCF ubiquitin ligase complex. (core.ac.uk)
Contain ankyrin repeats1
- The N-terminal cytoplasmic domain of TRPC, TRPV, and ANKTM (TRPA) channels contain ankyrin repeats, whereas the TRPC and TRPM contain proline-rich regions in the region just C-terminal to the predicted 6TM segment ( Fig. 2 ). (aspetjournals.org)
Designed ankyrin repeat protein libraries1
- High-affinity binders selected from designed ankyrin repeat protein libraries. (grstiftung.ch)
Second ankyrin repeat3
- We now report that nuclear localization of Ikappa Balpha is mediated by a novel nuclear import sequence within the second ankyrin repeat. (caltech.edu)
- Furthermore, a region encompassing the second ankyrin repeat of Ikappa Balpha is able to function as a discrete nuclear import sequence. (caltech.edu)
- Interacts (via the second ankyrin repeat cluster) with DDX58 . (sdsc.edu)
Amino6
- Ankyrin repeats are tandemly repeated modules of about 33 amino acids. (ebi.ac.uk)
- This repeating sequence of 33- Amino Acids was discovered in Ankyrin where it is involved in interaction with the anion exchanger ( Anion Exchange Protein 1, Erythrocyte ). (online-medical-dictionary.org)
- They are based on a very different structure (Supplementary Fig. S1) and are built from consecutive 33-amino acid repeats, each forming a β-turn followed by two antiparallel α-helices. (aacrjournals.org)
- Canonical-type transient receptor potential 3 (TRPC3) contains an ankyrin repeat (AR) region at the N-terminus (38-188 amino acids) and forms extracellular Ca2 +- entry channels by homo or heteromerization with other TRP subtypes in various cells including skeletal myotubes. (bentham.co.uk)
- Biochemical studies and deletion mutation analyses indicate that the 11-amino acid sequence between amino acids 717 and 727 of Tiam1 ( 717 GEGTDAVKRS 727 L) is the ankyrin-binding domain. (rupress.org)
- Using an Escherichia coli -derived calmodulin-binding peptide (CBP)-tagged recombinant Tiam1 (amino acids 393-728) fragment that contains the ankyrin-binding domain, we have detected a specific binding interaction between the Tiam1 (amino acids 393-738) fragment and ankyrin in vitro. (rupress.org)
Domains5
- Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. (ebi.ac.uk)
- Ankyrin repeats typically fold together to form a single, linear solenoid structure called ankyrin repeat domains. (wikipedia.org)
- Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via protein-protein interactions. (online-medical-dictionary.org)
- Both the ankyrin repeat and C-terminal transactivation domains were required for T-cell leukemogenesis, whereas the N-terminal RAM domain and a C-terminal domain that includes a PEST sequence were nonessential. (asm.org)
- Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains. (ox.ac.uk)
Cardiac2
- In a one-year re-integration phase I will perform follow-up mechanistic structural studies in the Olga Mayans lab (University of Liverpool) to determine the structural basis how the CARP (cardiac ankyrin repeat protein)-titin signaling axis mediates cardiomyocyte protection, and in the Labeit lab (University of Heidelberg, Medical Faculty Mannheim) how to perturb activity of this complex by small molecules. (thefreedictionary.com)
- A multiprotein complex encompassing a transcription regulator, cardiac ankyrin repeat protein (CARP), and the calpain 3 protease was identified in the N2A elastic region of the giant sarcomeric protein titin. (elsevier.com)
Encodes2
- This locus encodes an ankyrin repeat domain-containing protein. (wikipedia.org)
- Lr14a encodes a membrane-localized protein containing twelve ankyrin (ANK) repeats and structural similarities to Ca$^{2+}$-permeable non-selective cation channels. (edu.sa)
TRPA17
- Biopharmaceutical company Cubist Pharmaceuticals Inc (NASDAQ:CBST) and Hydra Biosciences Inc announced on Tuesday the joint proposal to commence a Phase 1 clinical study for a small molecule antagonist of the human Transient Receptor Potential Ankyrin repeat 1 (TRPA1) ion channel. (thefreedictionary.com)
- today announced plans to begin a Phase 1 clinical trial for a small molecule antagonist of the human Transient Receptor Potential Ankyrin repeat 1 (TRPA1) ion channel discovered in a collaboration between Cubist and Hydra. (thefreedictionary.com)
- o-Chlorobenzylidene malononitrile (CS) is a selective and potent agonist of the transient receptor potential ankyrin repeat 1 (TRPA1), which is a transducer molecule in nociceptors sensing reactive chemical species. (ovid.com)
- Here, we demonstrate based on Förster resonance energy transfer (FRET) and bilayer patch-clamp studies, a direct calmodulin-independent action of calcium on the purified human TRPA1 (hTRPA1), causing structural changes and activation without immediate subsequent desensitization of hTRPA1 with and without its N-terminal ankyrin repeat domain (N-ARD). (nanion.de)
- Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. (bioportfolio.com)
- Transient Receptor Potential Ankyrin-1 (TRPA1) Channel Contributes to Myocardial Ischemia-Reperfusion Injury. (bioportfolio.com)
- Ionic channels such as the transient receptor potential ankyrin 1 (TRPA1) are essential for the detection and transmission of painful stimuli. (bioportfolio.com)
Protein-protein inte1
- The residues on the wide lateral surface of ankyrin repeat structures are variable, often hydrophobic, and involved mainly in mediating protein-protein interactions. (wikipedia.org)
Asparagine1
- Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold. (ox.ac.uk)
Cytoskeletal protein1
- Immunoprecipitation and immunoblot analyses indicate that Tiam1 and the cytoskeletal protein, ankyrin, are physically associated as a complex in vivo. (rupress.org)
SOCS1
- They contain ankyrin repeat sequence and SOCS box domain. (creative-biogene.com)
Mediate1
- GABPβ contains four-and-a-half ankyrin repeats at its NH 2 -terminus that mediate heterodimerization with GABPα ( 17 ). (sciencemag.org)
Interaction6
- The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. (ebi.ac.uk)
- This interaction is mediated by giant Ankyrins, that act as specialized adaptors to establish and maintain axonal and synaptic compartments. (uni-kl.de)
- Analysis of truncated forms of ov008 revealed that the ANK repeat domain is the site of interaction between ov008 and FIH-1. (otago.ac.nz)
- Together the results suggest the 1st ANK repeat of ov008 determines the interaction of ov008 with FIH-1 while the 4th repeat may have a role in maintain the overall structure of the ov008 ANK repeat domain. (otago.ac.nz)
- Shank1 when it is not associated to GKAP, which binds to the Shank PSD-95-Discs Large-zona occludens-1 domain, forms filamentous and fusiform structures in which the Src homology 3 domain specifically interacts with the ankyrin repeat domain, thus allowing its multimerization via a novel form of intermolecular interaction. (jneurosci.org)
- These findings suggest that ankyrin-Tiam1 interaction plays a pivotal role in regulating Rac1 signaling and cytoskeleton function required for oncogenic signaling and metastatic breast tumor cell progression. (rupress.org)
Fold5
- The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. (ebi.ac.uk)
- The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [ PMID: 8875926 , PMID: 9353127 , PMID: 9461436 , PMID: 9865693 ]. (ebi.ac.uk)
- An artificial protein design based on a consensus sequence derived from sequence alignment has been synthesized and found to fold stably, representing the first designed protein with multiple repeats. (wikipedia.org)
- Most studies have found that ankyrin repeats fold in a two-state folding mechanism, suggesting a high degree of folding cooperativity despite the local inter-residue contacts and the evident need for successful folding with varying numbers of repeats. (wikipedia.org)
- p16C has moderately stable secondary and tertiary structure, with the ANK repeats adopting a similar topological fold as in the full-length protein. (uconn.edu)
Skeletal muscle1
- Heteromeric TRPC3 with TRPC1 formed via its ankyrin repeats regulates the resting cytosolic Ca 2+ levels in skeletal muscle. (bentham.co.uk)
Intracellular2
- In all six members of TRPV channel subfamily, there is an ankyrin repeat domain (ARD) in their intracellular N-termini. (rcsb.org)
- We identified three missense substitutions (R269H, R315W and R316C) affecting the intracellular N-terminal ankyrin domain of the TRPV4 ion channel in five families. (nih.gov)
ELISA ELISA Kit2
- Your search returned 20 Ankyrin repeat domain 12 ELISA ELISA Kit across 6 suppliers. (biocompare.com)
- Your search returned 13 Ankyrin repeat domain 29 ELISA ELISA Kit across 1 supplier. (biocompare.com)
Kinase3
- failed verification] The variation may affect the specificity of protein interactions made by the ANKK1 protein kinase through this repeat[citation needed]. (wikipedia.org)
- Receptor interacting protein kinase (RIPK) family: ankyrin repeat and kinase domain containing 1. (guidetopharmacology.org)
- The Ankyrin-Repeat Rich Membrane Spanning (ARMS)/kinase D-interacting substrate-220 kDa (Kidins220) serves as a unique downstream adaptor protein of Trk receptor tyrosine kinases. (snu.ac.kr)
Tumor1
- Cotransfection of SP1 cells with green fluorescent protein (GFP)-tagged Tiam1 fragment cDNA and Tiam1 cDNA effectively blocks Tiam1-ankyrin colocalization in the cell membrane, and inhibits GDP/GTP exchange on Rac1 by ankyrin-associated Tiam1 and tumor-specific phenotypes. (rupress.org)
TRPC1
- ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. (bioportfolio.com)
Residues1
- Here, we report that histidinyl residues within the ankyrin repeat domain of tankyrase-2 can be hydroxylated by FIH. (ox.ac.uk)
Cytosolic1
- We describe the structure of the cytosolic ankyrin repeat domain (ARD) of TRPV1 and identify a multiligand-binding site important in regulating channel sensitivity within the TRPV1-ARD. (semanticscholar.org)
DARPin1
- The designed ankyrin repeat protein (DARPin) G3 binds HER2 with high affinity at an epitope that does not overlap with trastuzumab and is biologically inert. (nih.gov)
Transient1
- Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models. (bioportfolio.com)
Antiparallel1
- The beta strands on adjacent ankyrin repeats combine to form a short antiparallel beta sheet. (thefreedictionary.com)