Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding. (1/262)
The type 1 sigma receptor expressed in Xenopus oocytes showed binding abilities for the sigma-1 ligands, [3H](+)pentazocine and [3H]NE-100, with similar kinetic properties as observed in native tissue membranes. Amino acid substitutions (Ser99Ala, Tyr103Phe and di-Leu105,106di-Ala) in the transmembrane domain did not alter the expression levels of the type 1 sigma receptor as determined by immunoblot analysis using an anti-type 1 sigma receptor antiserum. By contrast, ligand binding was significantly suppressed by the substitutions. These findings provide evidence that the transmembrane domain of the type 1 sigma receptor plays a critical role in ligand binding of this receptor. (+info)A-Current down-modulated by sigma receptor in frog pituitary melanotrope cells through a G protein-dependent pathway. (2/262)
Gramicidin perforated patch-clamp recordings were used to study the effects of two sigma 1 receptor ligands, (+)-N-cyclopropylmethyl-N-methyl-1, 4-diphenyl-1-ethyl-but-3-en-1-ylamine hydrochloride (JO 1784) and (+)-pentazocine, on the transient outward potassium current (IA) in cultured frog melanotrope cells. (+)-Pentazocine reversibly decreased the current amplitude in a dose-dependent manner. The effects of (+)-pentazocine were mimicked by JO 1784 and were markedly reduced by the sigma 1 receptor antagonist, N, N-dipropyl-2-[4-methoxy-3-2(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE 100). Inactivation rate of IA was best fitted with a double exponential function, yielding time constants of 23.7 and 112.5 ms. (+)-Pentazocine (20 microM) accelerated the current decay, decreasing the time constants to 10.7 and 59 ms, respectively. Current-voltage experiments revealed that (+)-pentazocine (20 microM) did neither modify the open-state I/V curves nor the voltage dependence of IA. However, (+)-pentazocine (20 microM) shifted the steady-state inactivation curve toward more negative potentials and increased the time constant of the time-dependent removal of inactivation. In whole-cell experiments, internal dialysis of guanosine-5'-O-(3-thiophosphate) (100 microM) irreversibly prolonged the response to (+)-pentazocine. In addition, cholera toxin pretreatment (1 microgram. ml-1; 12 h) suppressed the inhibition of IA by (+)-pentazocine (20 microM). It is concluded that in frog melanotrope cells, a cholera toxin-sensitive, G protein-dependent inhibition of IA through a sigma 1 receptor activation, at least partially, underlies the excitatory effect of sigma ligands. (+info)Sigma1 recognition sites in rabbit iris-ciliary body: topical sigma1-site agonists lower intraocular pressure. (3/262)
In this study, we examined the presence of sigma1 and sigma2 sites in the rabbit iris-ciliary body by receptor binding and investigated their effects on intraocular pressure (IOP) in albino rabbits. The iris-ciliary body has binding sites for the sigma1-site agonist [3H](+)-pentazocine (Kd = 4.6 nM; Bmax = 212 fmol/mg protein) and sigma2 sites labeled with [3H]1,3-di-o-tolylguanidine (DTG) (Kd = 8. 2 nM; Bmax = 1120 fmol/mg protein). In competition binding studies, (+)-pentazocine and the sigma antagonist NE-100 displayed high affinity for sigma1 sites (Ki = 2.1 and 2.4 nM, respectively), whereas (+)-N-allylnormetazocine (NANM) was less potent (Ki = 178 nM). Unilateral topical (+)-pentazocine (0.01-0.1%) caused a significant dose-related reduction of IOP in ocular normotensive rabbits and in the alpha-chymotrypsin model of ocular hypertension. (+)-NANM was less potent than (+)-pentazocine. Neither compound altered the IOP of the contralateral eye, and their hypotensive activity was blocked by NE-100 that, by itself, had no effect on IOP. (-)-Pentazocine, (-)-NANM, and DTG had no effect on IOP. DTG prevented the hypotensive effect of (+)-pentazocine, suggesting that it acts as a sigma1-site antagonist. sigma-Site ligands did not affect pupil diameter or cause ocular inflammation. Topical [3H](+)-pentazocine reaches the intraocular tissues within 30 min, and its uptake in the iris-ciliary body and retina was significantly reduced by topical pretreatment with NE-100, as expected for a receptor-specific agent. Reverse-phase HPLC confirmed the presence of intact (+)-pentazocine in iris-ciliary body homogenates. sigma1-Site agonists may offer a novel class of agents potentially effective in the control of ocular hypertension. (+info)Mechanism-based inactivation of rat liver cytochrome P-450 2B1 by 2-methoxy-5-nitrobenzyl bromide. (4/262)
Mechanism-based inactivators serve as probes of enzyme mechanism, function, and structure. Koshland's Reagent II (2-methoxy-5-nitrobenzyl bromide, KR-II) is a potential mechanism-based inactivator of enzymes that perform O-dealkylations. The major phenobarbital-inducible form of cytochrome P-450 in male rat liver microsomes, CYP2B1, is capable of catalyzing O-dealkylations. The interactions of KR-II with purified CYP2B1 in the reconstituted system containing P-450, NADPH:P-450 oxidoreductase, and sonicated dilaurylphosphatidyl choline were studied. The benzphetamine N-demethylase activity of CYP2B1 was inactivated by KR-II in a time- and NADPH-dependent manner, and the loss of activity followed pseudo-first-order kinetics. The inactivation also required KR-II, and the rate of activity loss was dependent on the concentration of KR-II in a saturable fashion. The inactivator concentration required for the half-maximal rate of inactivation (KI) was approximately 0.1 mM. The inactivation was not prevented by the addition of the nucleophiles dithiothreitol and glutathione, nor was it reversed by gel filtration. The present results demonstrate that KR-II is a mechanism-based inactivator of rat CYP2B1. (+info)Odor response properties of rat olfactory receptor neurons. (5/262)
Molecular biology studies of olfaction have identified a multigene family of molecular receptors that are likely to be involved in odor transduction mechanisms. However, because previous functional data on peripheral coding were mainly collected from inferior vertebrates, it has been difficult to document the degree of specificity of odor interaction mechanisms. As a matter of fact, studies of the functional expression of olfactory receptors have not demonstrated the low or high specificity of olfactory receptors. In this study, the selectivity of olfactory receptor neurons was investigated in the rat at the cellular level under physiological conditions by unitary extracellular recordings. Individual olfactory receptor neurons were broadly responsive to qualitatively distinct odor compounds. We conclude that peripheral coding is based on activated arrays of olfactory receptor cells with overlapping tuning profiles. (+info)New studies on trans-anethole oxide and trans-asarone oxide. (6/262)
The widespread use of naturally occurring alkenylbenzenes as flavoring and fragrance agents has led to a long-standing interest in their toxicity and carcinogenicity. Among them several allyl- and propenylbenzenes have been found to be mutagenic and carcinogenic. It has been shown that the carcinogenicity of several allylbenzenes can be related to the formation of electrophilic sulfuric acid esters following 1'-hydroxylation. Unlike the allylbenzenes, the mechanisms of carcinogenesis of propenylbenzenes such as anethole and asarone are not clear. It has been reported that one of the main metabolic pathways of trans-anethole is the epoxidation of the side chain 1,2-double bond, which was responsible for cytotoxicity but not for genotoxicity. However, we report here that synthetic trans-anethole oxide prepared from trans-anethole and dimethyldioxirane is not only mutagenic for Salmonella tester strains but is also carcinogenic in the induction of hepatomas in B6C3F1 mice and skin papillomas in CD-1 mice. Synthetic trans-asarone oxide was also carcinogenic in the induction of hepatomas as well as mutagenic for Salmonella strains. Further studies are needed on these side chain oxides of trans-anethole and trans-asarone as possible metabolites in the toxicity, mutagenicity and carcinogenicity of these and other propenylbenzenes. (+info)Dose-response trend tests for tumorigenesis, adjusted for body weight. (7/262)
Several studies have demonstrated a relationship between rodent body weight and tumor incidence for some tissue/organ sites. It is not uncommon for a chemical tested for carcinogenicity to also affect body weight. In such cases, comparisons of tumor incidence may be biased by body-weight differences across dose groups. A simple procedure was investigated for reducing this bias. This procedure divides the animals into a few groups based on body weight. Body weight at 12 months was used, before the appearance of a tumor was likely to affect body weight. Statistics for dose-response trend tests are calculated within body weight strata and pooled to obtain an overall dose-response trend test. This procedure is analogous to that currently used, of stratifying animals, based on their age at the time of removal from a study. Age stratification is used to account for differences in animal age across dose groups, which can affect comparisons of tumor incidence. Several examples were investigated where the high-dose group had reduced body weights and associated reductions in tumor incidence. When the data were analyzed by body-weight strata, some positive dose-response trends for tumor incidence were demonstrated. In one case, the weight-adjusted analysis indicated that a negative dose-response trend in tumor incidence was a real effect, in addition to a body weight reduction. These examples indicate that it is important to consider the effects of body weight changes as low as 10%, and perhaps below, that were caused by chemicals in 2-year bioassays for carcinogenesis. The simple procedure of analyzing tumor incidence within body-weight strata can reduce the bias introduced by weight differences across dose groups. (+info)Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest. (8/262)
We have found that the bicyclic colchicine analogue 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-on e (MTC) induced a dose- and time-dependent apoptotic response in human leukemic cells. MTC and colchicine rapidly disrupted the microtubule integrity and arrested cells at the G2-M phase before the onset of apoptosis. These responses were mediated by microtubule inhibition because 2-methoxy-5-[[3-(3,4,5-trimethoxyphenyl)propionyl]amino]-2,4,6-cycloh eptatrien-1-one and lumicolchicine, inactive analogues of MTC and colchicine, respectively, were unable to promote microtubule disassembly, cell cycle arrest, and apoptosis. Although 1 microM MTC induced a complete microtubule disruption after 1 h of incubation in human leukemic HL-60 cells that led to an accumulation of cells at the G2-M phase, MTC-induced apoptosis occurred after 9 h of treatment. This indicates the existence of a rather long lag between microtubule disruption and the onset of apoptosis. Unlike colchicine, the removal of MTC during this lag resulted in rapid microtubule repolymerization, followed by restoration of normal cell cycle and cell growth. MTC, but not 2-methoxy-5-[[3-(3,4,5-trimethoxyphenyl)-propionyl]amino]-2,4,6-cyclo heptatrien-1-one, induced c-jun expression as well as c-Jun NH2-terminal kinase and caspase activation, indicating that these signaling pathways are triggered by the specific action of MTC on microtubules. Caspase inhibition prevented MTC-induced apoptosis. Overexpression of bcl-2 or bcl-xL by gene transfer in human erythroleukemic HEL cells abrogated MTC-induced apoptosis, but cells remained arrested in G2-M, suggesting that bcl-2 and bcl-xL block the signaling pathway between G2-M arrest and triggering of apoptosis. MTC-treated bcl-2 and bcl-xL-transfected HEL cells recovered their capacity to proliferate after MTC removal. These results indicate that microtubule inhibition induces G2-M arrest and apoptosis in leukemic cells, showing a lag phase between G2-M arrest and the onset of apoptosis, regulated by bcl-2 and bcl-xL, during which MTC displays a reversible action on microtubule depolymerization and G2-M cell cycle arrest. Thus, MTC is a potent apoptotic inducer on human leukemic cells and shows a remarkable reversible action on microtubule network and cell cycle before commitment for apoptosis is reached. (+info)
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Anisole
For example, synthetic anethole is prepared from anisole. Anisole is relatively nontoxic with an LD50 of 3700 mg/kg in rats. ... For example, P4S10 converts anisole to Lawesson's reagent, [(CH3OC6H4)PS2]2. Also indicating an electron-rich ring, anisole ... from Anisole". Organic Syntheses. 57: 107. doi:10.15227/orgsyn.057.0107. G. S. Hiers and F. D. Hager (1929). "Anisole". Organic ... CH3I Birch reduction of anisole gives 1-methoxycyclohexa-1,4-diene. Anisole is prepared by methylation of sodium phenoxide with ...
2-(Diphenylphosphino)anisole
... is the organophosphorus compound with the formula (C6H5)2PC6H4-2-OCH3. It is a white solid that is ... Reactivity and Structure of Dichlorobis(o-(diphenylphosphino)anisole)ruthenium(II)". Inorganic Chemistry. 18: 2658. doi:10.1021 ...
Methylation
Hiers, G. S. (1929). "Anisole". Organic Syntheses. 9: 12. doi:10.15227/orgsyn.009.0012. Icke, Roland N.; Redemann, Ernst; ... A wide variety of phenols undergo O-methylation to give anisole derivatives. This process, catalyzed by enzymes such as ...
Phenol ether
Anisole is formally known as methoxybenzene, and is formed through the condensation of methanol (CH3OH) and phenol; due to the ... Anisole (C6H5OCH3) is the simplest phenol ether, and is a versatile precursor for perfumes and pharmaceuticals. Vanillin and ... "Anisole". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-03-29. Lipinski, Christopher A. (December 2004). "Lead- and drug-like ... compared to 3500-4000 mg/kg for anisole, the methyl ether. Furthermore, ethers are significantly more hydrophobic than phenols ...
Alkylation
G. S. Hiers and F. D. Hager (1941). "Anisole". Organic Syntheses.; Collective Volume, vol. 1, p. 58 H. Perst; D. G. Seapy (2008 ...
4-Bromoanisole
Anisole Stille, J. K.; Echavarren, Antonio M.; Williams, Robert M.; Hendrix, James A. (1993). "4-Methoxy-4'-Nitrobiphenyl". ...
Butylated hydroxyanisole
Anisole "BHA and BHT". Retrieved Nov 20, 2009. "SciFinder - Experimental properties for 121-00-6". Retrieved Nov 20, 2009. ...
Ethyl phenyl ether
PhOH + NaOH -----> Ph-O-Na Ph-O-Na + Et2SO4 ------> Ph-O-Et This reaction follows Sn2 path.[citation needed] Anisole "Phenetole ...
Creosote
... better-known as anisole, and water, which is not shown in the diagram. Anisole is listed as an acute hazard to aquatic life ... Balsama et al 1984 "Anisole". PubChem Database. National Center for Biotechnology Information. Retrieved April 7, 2019. Clarke ...
Murburn concept
"Biohalogenation as a source of halogenated anisoles in air". Chemosphere. 22 (5-6): 557-567. Bibcode:1991Chmsp..22..557W. doi: ...
Tris(4-methoxyphenyl)phosphine
Triphenylphosphine 2-(Diphenylphosphino)anisole Evans, D.; Osborn, J. A.; Wilkinson, G. (1968). "Hydroformylation of alkenes by ...
Cresol
Anisole converts to cresols under these conditions. Cresols are precursors or synthetic intermediates to other compounds and ...
Fritsch-Buttenberg-Wiechell rearrangement
Wiechell, H. (1894). "Condensation des Dichloracetals mit Anisol und Phenetol". Justus Liebig's Annalen der Chemie. 279 (3): ...
Methoxy group
Other methoxy ethers include anisole and vanillin. Many alkoxides contain methoxy groups, e.g. tetramethyl orthosilicate and ...
Hexamethylbenzene
Both anisole and pentamethylbenzene have been reported as intermediates in the process. Valentin Koptyug and co-workers found ... Formation of anisole, methylated phenols, and hexamethylbenzene". J. Chem. Soc.: 821-823. doi:10.1039/JR9450000821. PMID ... though as part of a complex mixture of anisole (methoxybenzene), cresols (methylphenols), and other methylated phenols. An ...
Ether
Methyl phenyl ether is anisole, because it was originally found in aniseed. The aromatic ethers include furans. Acetals (α- ... Illustrative unsymmetrical ethers are anisole (methoxybenzene) and dimethoxyethane. Vinyl- and acetylenic ethers are far less ...
2-Methoxybenzaldehyde
2-Anisaldehyde is prepared commercially by formylation of anisole. A. J. Sisti (1964). "o-Anisaldehyde". Org. Synth. 44: 4. doi ...
Retained name
Glycerol and acetic acid are examples of retained semisystematic names; furan and anisole are examples of retained trivial ...
Latamoxef
Deblocking with aluminium chloride and anisole gives moxalactam 14. Weitekamp MR, Aber RC (1983). "Prolonged bleeding times and ...
Tert-Butyloxycarbonyl protecting group
... scavengers such as anisole or thioanisole may be used. Selective cleavage of the N-Boc group in the presence of other ...
Di-tert-butyl dicarbonate
... scavengers such as anisole or thioanisole may be used. Selective cleavage of the N-Boc group in the presence of other ...
Birch reduction
doi:10.1016/0040-4020(59)85008-0. Burnham, D. R. (1969). "Orientation in the mechanism of the Birch reduction of anisole". ... Electron donors tend to induce ortho protonation, as shown in the reduction of anisole (1). Electron-withdrawing substituents ...
Zeisel determination
Synthetic applications: Experimental procedure with anisole and methylbenzoate Zeisel, S (1885). "Über ein Verfahren zum ...
Physical organic chemistry
... anisole" (PDF). Journal of Physical Organic Chemistry. 25 (10): 878-882. doi:10.1002/poc.2939. Chen, Chen; Ke, Jiyuan; Zhou, X ...
Desorption atmospheric pressure photoionization
The transfer of positive ions, such as protons and charge transfers, are seen with the solvents: toluene and anisole. Toluene ... Some of the common solvents include: nitrogen, toluene, acetone, and anisole. The desorption process can occur by two ...
Fulvio Cacace
"Gas-phase reaction of free isopropyl ions with phenol and anisole". (1980) "Aromatic substitution in the gas phase. A ... "Gas-phase reaction of free isopropyl ions with phenol and anisole". Journal of the Chemical Society, Perkin Transactions 2, ...
2,4-Dinitroanisole
It has an anisole (methoxybenzene) core, with two nitro groups (-NO2) attached. It is not explosive itself unless it is mixed ...
Holotrichia reynaudi
The male attractant pheromone, anisole was identified from abdominal glands of females. Anisole is also the sex pheromone of ...
Anethole
It is prepared commercially from 4-methoxypropiophenone, which is prepared from anisole. Anethole is distinctly sweet, ... On the constitution of anisol (anethol)]. Zeitschrift für Chemie. 2nd Series (in German). 2: 472-474. Media related to Anethole ...
Cyclohexenone
... is obtained by Birch reduction of anisole followed by acid hydrolysis. It can be obtained from cyclohexanone by α ...
RTECS:BZ8580500 - Anisole, 2,4-diamino- - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
Anisole Market Size: Global Industry Demand, Growth & Forecast 2027
The global Anisole market is expected to showcase a significant CAGR of 5.3% during the forecasted period 2018-2027. ... Anisole Overview. Anisole, also known as methoxybenzene can be defined as an organic compound and colorless liquid with smell ... The chemical formula of anisole is CH3OC6H5. Anisole has a good solubility in diethyl ether, ethanol, benzene, chloroform, ... Asia Pacific Anisole market captured significant share of global Anisole market in previous years. Advancement in technology ...
birch reduction of anisole
... Publikováno 14.11.2020 , Autor: [22] [23] More modern RHF computations lead to the same result. Are ... These steps are outlined below for the case of anisole. By using our site, you acknowledge that you have read and understand ... H. E. Zimmerman and P. A. Wang, J. English: Birch reduction of Anisole. [6]. In 1961 a simple computation of the electron ... isomeric transition states for protonation of the radical anion intermediate in the Birch reduction of anisole. EDGs are ...
Enhanced solar light absorption of graphene by interaction with anisole
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C. and treat with anisole (2mL, 7.8mmol) and then trifluoracetic acid (8mL). Stir for 2 hour under nitrogen atmosphere, ... and treat with anisole (150 .mu.L, 1.38mmol) and trifluoroacetic acid (0.8mL, 10.4mmol). Stir for 3.25 hours at room ... and treat with anisole (150 .mu.L, 1.38mmol) and trifluoroacetic acid (0.8mL, 10.4mmol). Stir for 3.25 hours at room ... and treat with anisole (150 .mu.L, 1.38mmol) and trifluoroacetic acid (0.8mL, 10.4mmol). Stir for 3.25 hours at room ...
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Ether2
- Anisole is prepared synthetically and is a pioneer of other synthetic compounds and it is ether. (researchnester.com)
- Anisole has a good solubility in diethyl ether, ethanol, benzene, chloroform, toluene and most of the organic solvents. (researchnester.com)
Methyl1
- 5. Production of methyl isocyanate, carbamate drugs, anisole. (sinochemi.com)
Outlook1
- Anisole market outlook The Anisole Market analysis and outlook report presents forecasts by Type, Application, country, and companies. (reportlinker.com)
Chemical1
- The chemical formula of anisole is CH 3 OC 6 H 5 . (researchnester.com)
Purity1
- The global anisole market is segmented on the basis of purity, application and geography. (researchnester.com)
Radical1
- To conclude, we characterise two (of the four) isomeric transition states for protonation of the radical anion intermediate in the Birch reduction of anisole. (pitbikemoravia.cz)
Market7
- The global Anisole market is expected to showcase a significant CAGR of 5.3% during the forecasted period 2018-2027. (researchnester.com)
- Additionally, the global Anisole market is thriving on the back rapid industrialization along with rising use of intermediate chemicals for manufacturing of other products such as polycarbonates, and detergents is expected to promote the expansion of capacity over the forecast period. (researchnester.com)
- Increasing consumption of cosmetic products such as perfumes is expected to increase the market size of anisole over the forecast period. (researchnester.com)
- In terms of regional platform, Europe Anisole market is projected to lead the growth of overall global Anisole market over the forecast period. (researchnester.com)
- Further, France, Germany, and the U.K are expected to contribute significantly in the growth of Anisole market in Europe region during the predicted period. (researchnester.com)
- Asia Pacific Anisole market captured significant share of global Anisole market in previous years. (researchnester.com)
- Advancement in technology and rising disposable income are key factors which are driving the growth of anisole market in Asia Pacific region. (researchnester.com)
English1
- H. E. Zimmerman and P. A. Wang, J. English: Birch reduction of Anisole. (pitbikemoravia.cz)
Results1
- Results also showed that anisole (EO extracted from Apiaceae) was not only effective against A. suspensa via contact, but also showed strong fumigation and residue effects. (usda.gov)
Groups1
- Particularly, compound 2 possesses a closed ionophoric cavity: the upper hemisphere is closed by three ten-butyl groups of anisole units and the lower hemisphere is closed by a mesitylene cap and three anisole methoxy groups. (elsevier.com)
Structure1
- Combined studies of 2 and 3 by MM3 computation, X-ray analysis, and 1 H NMR spectroscopy established that these calix[6]arenes feature a unique structure consisting of alternately-arranged three flattened mesitylene-linked phenyl units and three stand-up anisole units. (elsevier.com)
Significant1
- Analoog zijn de adsorptiecoëfficiënten van anisol en de primaire producten, fenol en cresol, ook statistisch significant. (scriptiebank.be)
Similar1
- The oxygenates in question, anisole, benzyl alcohol and 2-phenyl ethanol, have similar heating values and cetane numbers, but differ in the position of the functional oxygen group relative to the aromatic ring. (sae.org)
High1
- Factors such as, high awareness amongst the population regarding benefits of using Anisole such as manufacturing nanoparticles (tin oxide) and inorganic complexes, has resulted in an increasing demand for anisole. (researchnester.com)
Bromo Anisole5
- The top priority of our organization is to achieve utmost customer satisfaction by manufacturing and exporting a quality assured range of Meta Bromo Anisole . (suryalifesciencesltd.com)
- Packed by using quality approved packaging materials, our Meta Bromo Anisole is offered at the pocket friendly prices. (suryalifesciencesltd.com)
- Our company offers m - Bromo Anisole that is used as chemical intermediate It is a light yellow liquid that is formulated in our production unit in strict compliance with international quality norms. (suryalifesciencesltd.com)
- Wholesale Trader of a wide range of products which include industrial anisole and industrial bromo anisole. (neshiel.in)
- Clarion Drugs Ltd offers a wide range of products which includes 3-bromo anisole. (cphi-online.com)
Methoxybenzene5
- The Anisole is likewise recognized as Methoxybenzene. (express-press-release.net)
- Anisole, also known as methoxybenzene can be described as an organic compound and colourless liquid with smell similar to that of anise seed. (worldwidemarketreports.com)
- Anisole, (aka methoxybenzene) is one of the essential oils that give licorice its flavor and scent. (acsh.org)
- Here's a concrete example: the nitration of methoxybenzene (also known as anisole). (masterorganicchemistry.com)
- Cancer cells possess the next seven particular properties: 1) self-sufficiency in development indicators, 2) insensitivity to anti-growth indicators, 3) evasion of apoptosis, 4) unlimited replicative potential (the telomerase and Anisole Methoxybenzene telomere pathway), 5) suffered angiogenesis, 6) cells invasion and metastasis, and 7) genome instability.5,6 Generally, tumors are classified based on the differentiated component. (bollywooddvds.com)
Phenol4
- Phase 1 enzymes such as CYP2D6 and CYP3A4 catalyze the oxidation of anisole to phenol. (acsh.org)
- Upon consumption, anisole is converted by cytochrome P450 (CYP) enzymes to phenol (3) as shown in Figure 1. (acsh.org)
- With no catalyst present, anisole hydrolyzes to phenol in 97% yield after 24 hours at 365 °C, our experimentally determined optimal temperature and time. (usaigcnj.com)
- Electrophilic Fukui analysis was applied to anisole and phenol molecules to determine their reactivity to carbocation attack in catalytic reactions. (usaigcnj.com)
Toluene2
- Anisole has a good solubility in diethyl ether, ethanol, benzene, chloroform, toluene and most of the organic solvents. (worldwidemarketreports.com)
- Three different atmospheric pressure ionization (API) techniques, including photoionization (APPI) with four different dopants (acetone, anisole, chlorobenzene and toluene), heated electrospray ionization (HESI) and atmospheric pressure chemical ionization (APCI), were evaluated on the basis of method detection limits (MDLs) and recoveries from different aqueous matrixes. (nih.gov)
Benzene1
- Haken, J.K., Dispersion and selectivity indices of the halogenated derivatives of cyclohexane, benzene and anisole, J. Chromatogr. (chemspider.com)
Compounds2
- Anisole is prepared synthetically and is a precursor of other synthetic compounds and it is an ether. (worldwidemarketreports.com)
- The COSMOSIL PE-MS shows slightly longer retention time for compounds such as nitrobenzenes, which have electron acceptors, or electron donor compounds (such as anisole). (sesres.com)
54.9 million by 20222
- The global Anisole Market is anticipated to reach USD 54.9 million by 2022 and is expected to witness significant growth at a substantial CAGR for the duration of the prediction. (express-press-release.net)
- Anisole Market Reaching A Value Worth USD $54.9 Million By 2022: Grand View Research, Inc. (augustaheadlines.com)
Fluorobenzene1
- The rates of deuterium-protium exchange have been determined for o-, m- and p-deuterated fluorobenzene, benzotri-fluoride and anisole in liquid ammonia solution in the presence of potassium amide. (caltech.edu)
Model Compound2
- Mechanism of Hydroxyl Radical-Induced Breakdown of the Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4-D). If you are the author of this article you still need to obtain permission to reproduce Computational Study on Kinetics of Conversion of Bio-oil Model Compound - Anisole, to Platform Chemicals. (usaigcnj.com)
- As lignin has a very complex structure, anisole was used as a model compound. (undip.ac.id)
Synthetic1
- Anisole is a precursor of additional synthetic combinations. (express-press-release.net)
Fluorescence2
- Zn(II) binding to such a probe consisting of a tris(picolyl)amine-substituted acceptor site connected with an anisole donor moiety and an oxazole central core resulted in a significant increase of the two-photon absorption cross section (δ) and fluorescence brightness (ηδ). (edu.sa)
- Because many aromatic species fluoresce in the same spectral region as SO2 , fluorescence spectra were also measured for naphthalene and anisole to determine if ambient SO2 measurements could be biased in the presence of such species. (nasa.gov)
Organic1
- Industrial Anisole , is an organic compound. (neshiel.in)
Reaction2
- Methoxychlor was first synthesized in 1893 by the reaction of chloral hydrate with anisole in the presence of acetic acid and sulfuric acid. (cdc.gov)
- Kinetic analysis and reaction mechanism for anisole conversion over zirconia-supported molybdenum oxide, https://doi.org/10.1016/j.jcat.2019.06.046. (usaigcnj.com)
Products3
- Robust basis of the production of the scent products, combined with the growing demand in the nations such as Saudi Arabia, Brazil, Mexico, Germany, and the U.S.A, are estimated to motivate the anisole industry. (express-press-release.net)
- Necessity of these products in greater quantities drives the anisole market in a big measure even in emerging nations. (express-press-release.net)
- By the source of geography, the Europe is responsible for a bigger stake in the anisole industry and will display development in the U.K., Germany and France, as the necessity for cosmetic products are growing speedily. (express-press-release.net)
Yield1
- It was found that the use Pt-containing catalysts based on hypercrosslinked polystyrene in both processes of anisole and lignin-containing feedstock conversion allowed obtaining the highest yield of oxygen-free hydrocarbons (up to 96 wt. (undip.ac.id)
Terms1
- The company was incorporated in 2003, and within 17 years of incorporation the company has grown to be the largest manufacturer globally of MEHQ, BHA, Anisole and 4-MAP, in terms of installed manufacturing capacities as of March 31, 2021. (5paisa.com)
Price1
- The obtainability of the raw material and instability of the price continue as some of the biggest encounters in the anisole industry. (express-press-release.net)