A group of compounds that are derivatives of methoxybenzene and contain the general formula R-C7H7O.

Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding. (1/262)

The type 1 sigma receptor expressed in Xenopus oocytes showed binding abilities for the sigma-1 ligands, [3H](+)pentazocine and [3H]NE-100, with similar kinetic properties as observed in native tissue membranes. Amino acid substitutions (Ser99Ala, Tyr103Phe and di-Leu105,106di-Ala) in the transmembrane domain did not alter the expression levels of the type 1 sigma receptor as determined by immunoblot analysis using an anti-type 1 sigma receptor antiserum. By contrast, ligand binding was significantly suppressed by the substitutions. These findings provide evidence that the transmembrane domain of the type 1 sigma receptor plays a critical role in ligand binding of this receptor.  (+info)

A-Current down-modulated by sigma receptor in frog pituitary melanotrope cells through a G protein-dependent pathway. (2/262)

Gramicidin perforated patch-clamp recordings were used to study the effects of two sigma 1 receptor ligands, (+)-N-cyclopropylmethyl-N-methyl-1, 4-diphenyl-1-ethyl-but-3-en-1-ylamine hydrochloride (JO 1784) and (+)-pentazocine, on the transient outward potassium current (IA) in cultured frog melanotrope cells. (+)-Pentazocine reversibly decreased the current amplitude in a dose-dependent manner. The effects of (+)-pentazocine were mimicked by JO 1784 and were markedly reduced by the sigma 1 receptor antagonist, N, N-dipropyl-2-[4-methoxy-3-2(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE 100). Inactivation rate of IA was best fitted with a double exponential function, yielding time constants of 23.7 and 112.5 ms. (+)-Pentazocine (20 microM) accelerated the current decay, decreasing the time constants to 10.7 and 59 ms, respectively. Current-voltage experiments revealed that (+)-pentazocine (20 microM) did neither modify the open-state I/V curves nor the voltage dependence of IA. However, (+)-pentazocine (20 microM) shifted the steady-state inactivation curve toward more negative potentials and increased the time constant of the time-dependent removal of inactivation. In whole-cell experiments, internal dialysis of guanosine-5'-O-(3-thiophosphate) (100 microM) irreversibly prolonged the response to (+)-pentazocine. In addition, cholera toxin pretreatment (1 microgram. ml-1; 12 h) suppressed the inhibition of IA by (+)-pentazocine (20 microM). It is concluded that in frog melanotrope cells, a cholera toxin-sensitive, G protein-dependent inhibition of IA through a sigma 1 receptor activation, at least partially, underlies the excitatory effect of sigma ligands.  (+info)

Sigma1 recognition sites in rabbit iris-ciliary body: topical sigma1-site agonists lower intraocular pressure. (3/262)

In this study, we examined the presence of sigma1 and sigma2 sites in the rabbit iris-ciliary body by receptor binding and investigated their effects on intraocular pressure (IOP) in albino rabbits. The iris-ciliary body has binding sites for the sigma1-site agonist [3H](+)-pentazocine (Kd = 4.6 nM; Bmax = 212 fmol/mg protein) and sigma2 sites labeled with [3H]1,3-di-o-tolylguanidine (DTG) (Kd = 8. 2 nM; Bmax = 1120 fmol/mg protein). In competition binding studies, (+)-pentazocine and the sigma antagonist NE-100 displayed high affinity for sigma1 sites (Ki = 2.1 and 2.4 nM, respectively), whereas (+)-N-allylnormetazocine (NANM) was less potent (Ki = 178 nM). Unilateral topical (+)-pentazocine (0.01-0.1%) caused a significant dose-related reduction of IOP in ocular normotensive rabbits and in the alpha-chymotrypsin model of ocular hypertension. (+)-NANM was less potent than (+)-pentazocine. Neither compound altered the IOP of the contralateral eye, and their hypotensive activity was blocked by NE-100 that, by itself, had no effect on IOP. (-)-Pentazocine, (-)-NANM, and DTG had no effect on IOP. DTG prevented the hypotensive effect of (+)-pentazocine, suggesting that it acts as a sigma1-site antagonist. sigma-Site ligands did not affect pupil diameter or cause ocular inflammation. Topical [3H](+)-pentazocine reaches the intraocular tissues within 30 min, and its uptake in the iris-ciliary body and retina was significantly reduced by topical pretreatment with NE-100, as expected for a receptor-specific agent. Reverse-phase HPLC confirmed the presence of intact (+)-pentazocine in iris-ciliary body homogenates. sigma1-Site agonists may offer a novel class of agents potentially effective in the control of ocular hypertension.  (+info)

Mechanism-based inactivation of rat liver cytochrome P-450 2B1 by 2-methoxy-5-nitrobenzyl bromide. (4/262)

Mechanism-based inactivators serve as probes of enzyme mechanism, function, and structure. Koshland's Reagent II (2-methoxy-5-nitrobenzyl bromide, KR-II) is a potential mechanism-based inactivator of enzymes that perform O-dealkylations. The major phenobarbital-inducible form of cytochrome P-450 in male rat liver microsomes, CYP2B1, is capable of catalyzing O-dealkylations. The interactions of KR-II with purified CYP2B1 in the reconstituted system containing P-450, NADPH:P-450 oxidoreductase, and sonicated dilaurylphosphatidyl choline were studied. The benzphetamine N-demethylase activity of CYP2B1 was inactivated by KR-II in a time- and NADPH-dependent manner, and the loss of activity followed pseudo-first-order kinetics. The inactivation also required KR-II, and the rate of activity loss was dependent on the concentration of KR-II in a saturable fashion. The inactivator concentration required for the half-maximal rate of inactivation (KI) was approximately 0.1 mM. The inactivation was not prevented by the addition of the nucleophiles dithiothreitol and glutathione, nor was it reversed by gel filtration. The present results demonstrate that KR-II is a mechanism-based inactivator of rat CYP2B1.  (+info)

Odor response properties of rat olfactory receptor neurons. (5/262)

Molecular biology studies of olfaction have identified a multigene family of molecular receptors that are likely to be involved in odor transduction mechanisms. However, because previous functional data on peripheral coding were mainly collected from inferior vertebrates, it has been difficult to document the degree of specificity of odor interaction mechanisms. As a matter of fact, studies of the functional expression of olfactory receptors have not demonstrated the low or high specificity of olfactory receptors. In this study, the selectivity of olfactory receptor neurons was investigated in the rat at the cellular level under physiological conditions by unitary extracellular recordings. Individual olfactory receptor neurons were broadly responsive to qualitatively distinct odor compounds. We conclude that peripheral coding is based on activated arrays of olfactory receptor cells with overlapping tuning profiles.  (+info)

New studies on trans-anethole oxide and trans-asarone oxide. (6/262)

The widespread use of naturally occurring alkenylbenzenes as flavoring and fragrance agents has led to a long-standing interest in their toxicity and carcinogenicity. Among them several allyl- and propenylbenzenes have been found to be mutagenic and carcinogenic. It has been shown that the carcinogenicity of several allylbenzenes can be related to the formation of electrophilic sulfuric acid esters following 1'-hydroxylation. Unlike the allylbenzenes, the mechanisms of carcinogenesis of propenylbenzenes such as anethole and asarone are not clear. It has been reported that one of the main metabolic pathways of trans-anethole is the epoxidation of the side chain 1,2-double bond, which was responsible for cytotoxicity but not for genotoxicity. However, we report here that synthetic trans-anethole oxide prepared from trans-anethole and dimethyldioxirane is not only mutagenic for Salmonella tester strains but is also carcinogenic in the induction of hepatomas in B6C3F1 mice and skin papillomas in CD-1 mice. Synthetic trans-asarone oxide was also carcinogenic in the induction of hepatomas as well as mutagenic for Salmonella strains. Further studies are needed on these side chain oxides of trans-anethole and trans-asarone as possible metabolites in the toxicity, mutagenicity and carcinogenicity of these and other propenylbenzenes.  (+info)

Dose-response trend tests for tumorigenesis, adjusted for body weight. (7/262)

Several studies have demonstrated a relationship between rodent body weight and tumor incidence for some tissue/organ sites. It is not uncommon for a chemical tested for carcinogenicity to also affect body weight. In such cases, comparisons of tumor incidence may be biased by body-weight differences across dose groups. A simple procedure was investigated for reducing this bias. This procedure divides the animals into a few groups based on body weight. Body weight at 12 months was used, before the appearance of a tumor was likely to affect body weight. Statistics for dose-response trend tests are calculated within body weight strata and pooled to obtain an overall dose-response trend test. This procedure is analogous to that currently used, of stratifying animals, based on their age at the time of removal from a study. Age stratification is used to account for differences in animal age across dose groups, which can affect comparisons of tumor incidence. Several examples were investigated where the high-dose group had reduced body weights and associated reductions in tumor incidence. When the data were analyzed by body-weight strata, some positive dose-response trends for tumor incidence were demonstrated. In one case, the weight-adjusted analysis indicated that a negative dose-response trend in tumor incidence was a real effect, in addition to a body weight reduction. These examples indicate that it is important to consider the effects of body weight changes as low as 10%, and perhaps below, that were caused by chemicals in 2-year bioassays for carcinogenesis. The simple procedure of analyzing tumor incidence within body-weight strata can reduce the bias introduced by weight differences across dose groups.  (+info)

Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest. (8/262)

We have found that the bicyclic colchicine analogue 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1-on e (MTC) induced a dose- and time-dependent apoptotic response in human leukemic cells. MTC and colchicine rapidly disrupted the microtubule integrity and arrested cells at the G2-M phase before the onset of apoptosis. These responses were mediated by microtubule inhibition because 2-methoxy-5-[[3-(3,4,5-trimethoxyphenyl)propionyl]amino]-2,4,6-cycloh eptatrien-1-one and lumicolchicine, inactive analogues of MTC and colchicine, respectively, were unable to promote microtubule disassembly, cell cycle arrest, and apoptosis. Although 1 microM MTC induced a complete microtubule disruption after 1 h of incubation in human leukemic HL-60 cells that led to an accumulation of cells at the G2-M phase, MTC-induced apoptosis occurred after 9 h of treatment. This indicates the existence of a rather long lag between microtubule disruption and the onset of apoptosis. Unlike colchicine, the removal of MTC during this lag resulted in rapid microtubule repolymerization, followed by restoration of normal cell cycle and cell growth. MTC, but not 2-methoxy-5-[[3-(3,4,5-trimethoxyphenyl)-propionyl]amino]-2,4,6-cyclo heptatrien-1-one, induced c-jun expression as well as c-Jun NH2-terminal kinase and caspase activation, indicating that these signaling pathways are triggered by the specific action of MTC on microtubules. Caspase inhibition prevented MTC-induced apoptosis. Overexpression of bcl-2 or bcl-xL by gene transfer in human erythroleukemic HEL cells abrogated MTC-induced apoptosis, but cells remained arrested in G2-M, suggesting that bcl-2 and bcl-xL block the signaling pathway between G2-M arrest and triggering of apoptosis. MTC-treated bcl-2 and bcl-xL-transfected HEL cells recovered their capacity to proliferate after MTC removal. These results indicate that microtubule inhibition induces G2-M arrest and apoptosis in leukemic cells, showing a lag phase between G2-M arrest and the onset of apoptosis, regulated by bcl-2 and bcl-xL, during which MTC displays a reversible action on microtubule depolymerization and G2-M cell cycle arrest. Thus, MTC is a potent apoptotic inducer on human leukemic cells and shows a remarkable reversible action on microtubule network and cell cycle before commitment for apoptosis is reached.  (+info)

TY - JOUR. T1 - Alkali-metal-mediated zincation of anisole: synthesis and structures of three instructive ortho-zincated complexes. AU - Clegg, W AU - Dale, S H AU - Drummond, A M AU - Hevia, E AU - Honeyman, G W AU - Mulvey, R E PY - 2006/6/14. Y1 - 2006/6/14. N2 - The new concept of alkali-metal-mediated zincation (AMMZ), formally a zinc−hydrogen exchange reaction but one that requires the participation of an alkali metal, is applied here to the alkyl aryl ether anisole, an important molecule for studying directed ortho-metalation (DoM) chemistry. Treating one molar equivalent of anisole with the lithium dialkyl-TMP zincate reagent [THF·Li(μ-TMP)(μ-tBu)Zn(tBu)] (1) in hexane solution affords the mono-ortho-zincated complex [THF·Li(μ-TMP)(μ-o-C6H4OMe)Zn(tBu)] (2), which establishes that 1 functions as an alkyl base although previously it was regarded as an amido (TMP) base in other DoM applications. Treating two molar equivalents of anisole with 1, and increasing the reaction time, ...
Abstract : The objective of the present study was to evaluate the impact of biofield energy treatment on the thermal,spectroscopic, and chemical properties of anisole by various analytical methods such as gas chromatography-massspectrometry (GC-MS), high performance liquid chromatography (HPLC), differential scanning calorimetry (DSC),Fourier transform infrared (FT-IR) spectroscopy, and ultraviolet-visible (UV-Vis) spectroscopy. The anisole sample wasdivided into two parts, control and treated. The control part was remained same while the other part was treated withMr. Trivedis unique biofield energy treatment. Mass spectra showed the molecular ion peak with five fragmented peaksin control and all treated samples. The isotopic abundance ratio of 2H/1H, and 13C/12C [(PM+1)/PM] in treated samplewas increased by 154.47% (T1) as compared to the control [where, PM- primary molecule, (PM+1)-isotopic moleculeeither for 13C or 2H]. The HPLC chromatogram showed retention time of treated anisole was ...
1,3-Dimethoxybenzene 99%, ACROS Organics™ 100g; Glass bottle 1,3-Dimethoxybenzene 99%, ACROS Organics™ Dilaur to Dimethoxyh -Organics
I dont think polarization is the issue. Adding $\ce{FeBr3}$ is just to reduce the $\ce{Br-Br}$ bond strength, speeding up the reaction (attack of the aromatic ring on the bromine is part of the rate determining step, which is slow in the bromination of benzene). It functions as a catalyst being recycled when the $\ce{Br-}$ grabs a $\ce{H+}$ to restore aromaticity in the ring. Im pretty sure - at least I see no reason to doubt - that the catalyst requirements for the bromination of anisole and the bromination of phenol do not differ much, if at all. That is, no catalyst is required for the bromination of anisole.. ...
Acetophenone and benzophenone propiophenone series,Anisole and phenol and thiophenol series,Aniline series,Benzaldehyde and benzaldehyde oxime and phenylpropionaldehyde and phenyl acetaldehydeseries,Benzene and biphenyl series,Benzoic acid and benzoyl chloride series,Benzonitrile and benzoylacetonitrile and Benzamide Thiobenzamide series,Benzotrifluoride series,Benzyl alcohol and benzyl halogen and phenethyl alcohol and Styrene,Benzylamine and phenylethylamine series,Boronic acid series,Cinnamic aldehyde and Cinnamic acid series,Indole and indanone,Isatin and benzene sulfonylchloride and benzoylformate series,Phenyl acetonitrile and Phenylacetic acid and phenylpropionic acid and benzoylacetate series,Phenyl isocyanate phenyl isothiocyanate series,Phenylhydrazine series,Phthalic acid and anhydride series,Other,,Aromsyn Co.,Ltd.
Solution How Do You Convert the Following : Phenol to Anisole Concept: Preparation of Ethers from Dehydration of Alcohols and Williamson Systhesis.
Creative-Proteomics offer cas 87-40-1 2,4,6-TRICHLOROANISOLE UNLABELED 1 MG/ML IN METHANOL. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Estragole is suspected to be carcinogenic and genotoxic, as is indicated by a report of the European Union, Committee on Herbal Medicinal Products.[3] Several studies have clearly established that the profiles of metabolism, metabolic activation, and covalent binding are dose dependent and that the relative importance diminishes markedly at low levels of exposure (i.e. these events are not linear with respect to dose). In particular, rodent studies show that these events are minimal probably in the dose range of 1-10 mg/kg body weight, which is approximately 100-1000 times the anticipated human exposure to this substance. For these reasons it is concluded that the present exposure to estragole resulting from consumption of herbal medicinal products (short time use in adults at recommended posology) does not pose a significant cancer risk. In the meantime exposure of estragole to sensitive groups such as young children, pregnant and breastfeeding women should be minimized. The Scientific ...
First order-like plots, due to the large excess of methoxide, are obtained in each case, except with methyl benzoate (Plot 3) where metallic copper appeared after 1 hour (decomposition of catalyst). Slope ratio between the blank experiment (Plot 1) and the ethyl acetate one (Plot 6) is superior to 20, demonstrating the effectiveness of this co-catalyst (completion is reached within 45 min., with a quasi-quantitative yield).. Use of ethyl rather than methyl esters leads sometimes to traces of 2-ethoxy phenol (0.5 to 1%), due to releasing of ethoxide ion through transesterification of the co-catalyst by methoxide; methyl esters may therefore be preferred if highest purity of final product is required.. Anisole is also quasi-quantitatively obtained from bromobenzene in presence of ethyl acetate (10 mmole PhBr, 4 mmol EtOAc, 1,4 mmol CuBr in 6 ml 5M MeONa/MeOH, 98% conversion after 1h reflux, 100% after 2h, yield of isolated anisole >95% without detected phenetole).. Another example, of industrial ...
TY - JOUR. T1 - A porphyrin-based gelator assembly which is reinforced by peripheral urea groups and chirally twisted by chiral urea additives. AU - Tamaru, Shun Ichi. AU - Uchino, Shin Ya. AU - Takeuchi, Masayuki. AU - Ikeda, Masato. AU - Hatano, Tsukasa. AU - Shinkai, Seiji. PY - 2002/5/13. Y1 - 2002/5/13. N2 - A novel porphyrin (1b) bearing four urea groups at its periphery was synthesized. This compound tends to aggregate into one-dimensional direction, resulting in an organogel phase in anisole and diphenyl ether solvents. The gel can be formed even at 0.125 wt/vol% in anisole and the sol-gel phase transition temperatures (Tgel) are as high as 120-140°C, indicating that 1b acts as an excellent gelator for these specific solvents. The spectroscopic studies and electron-micrographic observations support the view that the π-π stacking interaction among porphyrin moieties and the hydrogen-bonding interaction among urea moieties operate synergistically to give rise to a stable one-dimensional ...
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam ...
Title:Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase. VOLUME: 19 ISSUE: 3. Author(s):Karolina Królewska-Golińska, Marcin J. Cieślak*, Milena Sobczak, Rafał Dolot, Ewa Radzikowska-Cieciura, Mariola Napiórkowska, Iwona Wybrańska and Barbara Nawrot. Affiliation:Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, 112 Sienkiewicza Str., 90-363 Lodz, Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Str., 02-007 Warsaw, ...
Sulfanilide / Thienothiazine / Methoxyaniline / Phenoxy compound / Anisole / Phenol ether / Methoxybenzene / 2,3,5-trisubstituted thiophene / Alkyl aryl ether / AralkylamineOrtho-thiazine / Organosulfonic acid amide / Organic sulfonic acid or derivatives / Organosulfonic acid or derivatives / Heteroaromatic compound / Sulfonyl / Thiophene / Aminosulfonyl compound / Secondary amine / Ether / Azacycle / Secondary aliphatic amine / Organoheterocyclic compound / Organic oxygen compound / Organic nitrogen compound / Hydrocarbon derivative / Organic oxide / Organosulfur compound / Organooxygen compound / Organonitrogen compound / Amine / Organopnictogen compound / Aromatic heteropolycyclic compound ...
5-phenylimidazole - 4-phenylimidazole - 1,2,4,5-tetrasubstituted imidazole - Phenoxy compound - Aryl thioether - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - Alkylarylthioether - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Heteroaromatic compound - Azacycle - Ether - Thioether - Sulfenyl compound - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Aromatic heteromonocyclic compound ...
How do the senses of wine enthusiasts detect cork taint (the presence of the chemical TCA)? Is it a certain smell, like the musty pages of an old hymnal, or is it indicated by a general dampening of aroma and flavor? Find out how much of the phenomenon is subjective-and when to open another bottle.
We have studied the pyrolysis of aromatic combustion intermediates using an array of detection techniques. The molecules investigated include cyclic aromatic molecules with hydrocarbon substituents (ethylbenzene, n-propylbenzene, isopropylbenzene, and styrene), oxygen-containing substituents (anisole and phenol), triply substituted systems (vanillin), resonance stabilized radicals (benzyl radical and tropyl radical) and phenyl radical. At the exit of a resistively heated micro-reactor (1 mm inner diameter, 3 cm long), the pyrolysis fragments are detected using photoionization mass spectrometry (PIMS), matrix isolation vibrational spectroscopy, microwave spectroscopy, tunable VUV synchrotron-based PIMS, and table-top VUV PIMS with photoelectron photoion coincidence spectroscopy (PEPICO). This array of detection methods allows for the identification of all possible fragments including metastables, radicals, and atoms. The findings allow for detailed mechanistic information regarding which pathways ...
Lawessons reagent (full name 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (or -disulphide) is a chemical compound with the formula C14H14O2P2S4, used in organic synthesis as a thiation (also called thionation or sulfuration) agent. This light yellow to beige powder has a strong and unpleasant odour.. Lawessons reagent was first produced in 1956 during a systematic study of the reactions of arenes with the comparable reagent P4S10. However it was Swedish chemist Sven-Olov Lawesson who popularized Lawessons reagent within the chemical community.. Being commercially available, Lawessons reagent can also be conveniently made in the laboratory by heating a mixture of anisole with phosphorus pentasulfide until the mixture is clear and no more hydrogen sulfide is formed, and then recrystallized from toluene or xylene.. The main application of Lawessons reagent is the thionation of carbonyl compounds - the carbonyl group is converted into thiocarbonyl group, carbon-oxygen ...
4-allylanisole, and three analogs, anisole, allylbenzene, and 4-isopropylanisole are demonstrated to be effective repellents for scolytid infestation. Conifers, a particular target for the scolytids, are protected by application of the compounds, either directly or suspended in a carrier.
A method and composition for the remediation of environmental contaminants in soil, sediment, aquifer material or water wherein contaminants are first reduced with a reducing agent found in sediment and are then oxidized to environmentally safe products. The composition includes a reducing agent, solubilized from sediment by a solvent, for reduction of environmental contaminants such as nitroorganics, halogenated hydrocarbons, cyano compounds, anisoles and metals.
You may also wish to search for items by Kumar. 27 matching references were found. Vatsa, R.K.; Kumar, A.; Naik, P.D.; Upadhyaya, H.P., et al., UV spectrum and decay kinetics of transient methylsilene produced in the 193 nm photolysis of gaseous 1-methyl-1-silacyclobutane, Chem. Phys. Lett., 1996, 255, 1-3, 129, https://doi.org/10.1016/0009-2614(96)00342-9 . [all data] Kumar, V.; Kumar, A., The study of afterglow spectra of nitrogen at different temperatures and pressures, Physica B+C: (Amsterdam), 1985, 132, 273-294. [all data] Kumar, A.; Meath, W.J., Pseudo-spectral dipole oscillator strengths and dipole-dipole and triple-dipole dispersion energy coefficients for HF, HCl, HBr, He, Ne, Ar, Kr and Xe, Mol. Phys., 1985, 54, 823-833. [all data] Kumar, A., Surface tension, viscosity, vapor pressure, density, and sound velocity for a system miscible continuously from a pure fused electrolyte to a nonaqueous liquid with a low dielectric constant: anisole, J. Am. Chem. Soc., 1993, 115, 9243-8. [all ...
The cell wall protein peptidoglycan complex (CW-PPC) ofMycobacterium tuberculosis H37Ra was isolated through sequential extraction of lipids, carbohydrates and soluble proteins. CW-PPC emulsified in FIA was found to induce significant protection in mice against challenge with LD50 dose ofM. tuberculosis H37Rv. To identify the immunoprotective components of CW-PPC, the proteins in avid association with peptidogican were dissociated by chemical treatment with trifluoromethanesulthonic acid (CF3CO3H): anisole (2:1). Immunoreactivity of total (CW-Pr) as well as its component proteins i.e., 71, 60 and 45 kDa proteins of cell wall was studied in animals immunized with CW-Pr-FIA. The 71 kDa protein was found to be most immunoreactive giving higher T-cell sensitization and humoral responses. Further, immunization of mice with 71 kDa-FIA demonstrated enhanced T- and B- cell responses. Mice immunized with 71 kDa-FIA gave significantly higher protection (P ≤ 0.05) against intravenous challenge with LD50 ...
As the situation with COVID-19 continues to unfold in every community, MedChemExpress is responding to the uncertainty caused by this outbreak thoughtfully and cautiously. Your need for high quality reagent doesnt stop during difficult times, and neither do we. Were doing our best to keep everyone healthy and safe in the workplace while also avoiding the interruptions to our day-to-day operations. If you need to change the delivery plan for items ordered, please contact us via email [email protected]. Thank you for being a loyal MedChemExpress customer, we are here to assist you as needed. ...
Resume Format Administrative Assistant Administrative - Aug 12, · Lab 2 Prelab Assignment 1. a. Complete Table 1. b. Benzoic acid and 4-tert-butylphenol are acids. Circle the acidic H in the structure of each acid. What is the pK a of each acid? Which H is the most acidic? In other words, which acid is the stronger acid? Give reasons. c. 4-tert-butylphenol and dimethoxybenzene are bases. The endocrine system and its hormones play a vital role in maintaining bodily functions and homeostasis. The anterior pituitary gland is responsible for the production of a majority of the hormones that the body produces, specifically the growth hormone. Growth hormone plays a leading part in many bodily aspects such as, helping young people to grow, and in adults it helps to with growth of. Lab #1: ANATOMY AND PHYSIOLOGY OF THE ENDOCRINE SYSTEM. References: Saladin, KS: Anatomy and Physiology, The Unity of Form and Function 7. th () ed. Be sure you have read and understand Chapter 17 before beginning this lab. ...
9,10-antracenodion · Anthradione, · 9,10-Anthrachinon · Antracen-9,10-chinon · 9,10-dihydro-9,10-dioksoantracen · Hoelit, Morkit, ...
2-Heptyl-4,5-dihydro-1H-imidazol-1-ethanol monohydrochloride/ACM94108880 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Buy high quality 1-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine Monohydrochloride 70918-74-0 from toronto research chemicals Inc.
List updated to include 1-cyclopropanemethyl-4-methoxybenzene; ethyl 5-formyloxydecanoate; Meyer lemon oil; and 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid.
Buy NUUO NVRmini2 NE-2040 NVR and Server (4-Channel, 2 Drive Bays, 3TB) features Streams & Records 4 IP Cameras, 4 Camera Events & 4 User Privileges. Review NUUO Network Video Recorders (NVRs), Video Recorders
Name L-(+)-Arginine hydrochloride. Synonyms L-Arginine hydrochloride; L-Arginine monohydrochloride; 2-Amino-5-guanidinovaleric acid monohydrochloride. Molecular Formula: C6H14N4O2.HCl. Molecular Weight: 210.66. CAS Registry Number: 1119-34-2. EINECS: 214-275-1. ...
For iCal, an .ics file will be downloaded to your computer or device. You may need to take additional steps to add the event to your personal calendar.. ...
For iCal, an .ics file will be downloaded to your computer or device. You may need to take additional steps to add the event to your personal calendar.. ...
A metabolite of beta-asarone is the reason Acurus calamus is known in some cultures as a psychedelic. However, not all Acorus calamus contains sufficient quantities of beta-asarone to be effective. Acorus calamus from Nepal typically contains a large amount of beta-asarone. Acorus calamus from India usually contains very little beta-asarone, and will cause extreme nausea before doses high enough to get some minor effects from beta-asarone are ingested.. Its important to note that beta-asarone itself is not active. One of its metabolites can produce psychedelic effects in man. Not everyones body metabolizes beta-asarone the same way, leading to different results for different individuals. Some people are not able to experience psychedelic effects from ingesting beta-asarone. This is because their bodies do not produce enough of the active metabolite to experience effects.. The active metabolite of beta-asarone is currently unidentified. There has been speculation of it being an amphetamine, ...
Therapeutic properties:. Below are a few therapeutic properties that research studies have shown regarding Trans-anethole ((E)-anethole). Please keep in mind these are for the specific chemical component and may not be representative of the entire essential oil it is found in depending on the percentages shown in gas chromatography and mass spectronomy analysis.. Analgesic: (E)-Anethole is moderately analgesic, in both in vitro and in vivo tests2. Antifungal: anethole has been shown to exhibit synergistic antifungal activity against a budding yeast3 and candida6. Anti-inflammatory: (E)-Anethole blocks cellular responses induced by Tumor Necrosis Factor indicating an anti-inflammatory action4 (TNF is a chemical messenger that induces cell death. TNF is directed at abnormal cells to assist in preventing the formation of tumors.). There was a study also that showed anethole to be a potential candidate in supporting the restoration of functional dyspepsia.5. Balanced use:. It is important to ...
We have shown previously that low doses of selective sigma (sigma)- receptor ligands potentiate the excitatory response of pyramidal neurons to NMDA in the CA3 region of the dorsal hippocampus in the rat. Because progesterone competitively displaces the binding of the ligand N-[3H]allyl-normetazocine (SKF-10,047), the present studies were undertaken to determine in vivo the effect of neuroactive steroids on NMDA-induced excitation of rat CA3 pyramidal neurons. Low doses of dehydroepiandrosterone (DHEA) potentiated the NMDA response selectively and dose-dependently. The effect of DHEA was reversed by the selective sigma antagonist N-dipropyl-2-(4-methoxy-3- (2-phenylethoxy)phenyl)- ethylamine monohydrochloride (NE-100) and by haloperidol, but not by spiperone. Progesterone had no effect by itself but reversed, at low doses, the potentiation of the NMDA response induced by DHEA as well as those induced by nonsteroidal sigma ligands. Neither pregnenolone nor pregnenolone sulfate had any effect on ...
Looking for online definition of o-anisidine in the Medical Dictionary? o-anisidine explanation free. What is o-anisidine? Meaning of o-anisidine medical term. What does o-anisidine mean?
Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
Discover the incredible weight loss benefits of anise, how to best prepare it and how much you should use to get maximum benefit from anise - one of natures amazing fat burning foods. Anise, alternately referred to as aniseed and sweet cumin, is categorized as both a vegetable and an herb; it is part of the same family where you would find fennel, dill, caraway, and cumin. The leaves, seeds, and flowers of anise can be put into foods as well as different medications. The anise plant is tall and has small, feathery green leaves. The plant has white flowers and its fruit, which is frequently referred to as a seed, has the appearance of a ribbed seed. Ripened anise seeds are greenish brown or gray-green in color. Anise tastes somewhat like fennel with a hint of licorice flavor. DieselHemp.com offers the best CBD joints. Fat Fighting Benefits of Anise. The medicinal qualities of anise have been known to man as far back as the ancient Egyptians and Romans. Anise aids in the bodys digestion and fat ...
1-Methoxy-4-(2-propenyl)benzene, also known as methylchavicol or estragol, belongs to the class of organic compounds known as anisoles. These are organic compounds containing a methoxybenzene or a derivative thereof. 1-Methoxy-4-(2-propenyl)benzene is an extremely weak basic (essentially neutral) compound (based on its pKa). 1-Methoxy-4-(2-propenyl)benzene is a sweet, alcohol, and anise tasting compound. Outside of the human body, 1-Methoxy-4-(2-propenyl)benzene is found, on average, in the highest concentration within a few different foods, such as anises, fennels, and sweet basils and in a lower concentration in cumins, tarragons, and parsley. 1-Methoxy-4-(2-propenyl)benzene has also been detected, but not quantified in, several different foods, such as citrus, chinese cinnamons, caraway, fats and oils, and cloves. This could make 1-methoxy-4-(2-propenyl)benzene a potential biomarker for the consumption of these foods. 1-Methoxy-4-(2-propenyl)benzene, with regard to humans, has been linked to ...
This study investigates the mechanisms of gas phase anisole and phenol conversion over zeolite catalyst. These monomers contain methoxy and hydroxyl groups, the predominant functionalities of the phenolic products of lignin pyrolysis. The proposed reaction mechanisms for anisole and phenol are distinct, with
Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. β-Asarone, which has significant pharmacological effects on the central nervous system (CNS), was used in the prevention of cerebral ischemia in this paper. The right middle cerebral artery occlusion model was used in the study. The effects of β-Asarone on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na+-K+-ATPase activity and glutathione S transferase activity in a rat model were studied respectively. β-Asarone significantly improved the neurological outcome after cerebral ischemia and reperfusion in terms of neurobehavioral function in rats. Meanwhile, supplementation of β-Asarone significantly boosted the defense mechanism
TY - JOUR. T1 - Rapid conversion of glycerol to lactic acid under alkaline hydrothermal conditions, by using a continuous flow reaction system. AU - Shimanouchi, Toshinori. AU - Ueno, Shouhei. AU - Shidahara, Kazuki. AU - Kimura, Yukitaka. PY - 2014. Y1 - 2014. N2 - A rapid conversion of glycerol to lactic acid (lactate) could be successfully achieved under alkaline hydrothermal conditions, by using a continuous flow reaction system. A rapid conversion by a continuous flow-type reaction system made it possible to achieve the reaction under high-temperature conditions without side reactions. The rapid conversion and high reaction yield (reaction: 2min; yield: 90%) resulted from the rapid temperature-shift advantageous for the inhibition of side reactions.. AB - A rapid conversion of glycerol to lactic acid (lactate) could be successfully achieved under alkaline hydrothermal conditions, by using a continuous flow reaction system. A rapid conversion by a continuous flow-type reaction system made it ...
1-tert-butyl-4-propan-2-yl-5-(trifluoromethyl)imidazole chemical properties, What are the chemical properties of 1-tert-butyl-4-propan-2-yl-5-(trifluoromethyl)imidazole 129247-52-5, What are the physical properties of 1-tert-butyl-4-propan-2-yl-5-(trifluoromethyl)imidazole ect.
2-(2-hydroxyethoxy)ethan-1-ol 2-[2-(2-hydroxyethoxy)ethoxy]ethan-1-ol 2-methoxyethan-1-ol 3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol 3,6,9,12,15-pentaoxaheptadecane-1,17-diol 3,6,9,12-tetraoxatetradecane-1,14-diol bis(ethane-1,2-diol) 14-({3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoyl}oxy)-3,6,9,12-tetraoxatetradecan-1-yl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate 14-hydroxy-3,6,9,12-tetraoxatetradecan-1-yl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate tris(17-({3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoyl}oxy)-3,6,9,12,15-pentaoxaheptadecan-1-yl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate) tris(17-hydroxy-3,6,9,12,15-pentaoxaheptadecan-1-yl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate) 2-({3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoyl}oxy)ethyl ...
Patients randomized to vernakalant received a 10-minute infusion of 3 mg/kg vernakalant in one infusion line, followed by a 15-minute observation period and an additional 10-minute infusion of 2 mg/kg vernakalant if still in AF. To maintain blinding, a 60-minute infusion of placebo (5% dextrose in water) was administered in a second infusion line, followed by a maintenance infusion of placebo for an additional 60 minutes. Patients randomized to amiodarone received a 60-minute infusion of 5 mg/kg amiodarone in one infusion line, followed by a maintenance infusion of 50 mg amiodarone over an additional 60 minutes (equivalent to approximately 15 mg/kg over 24 hours). To maintain blinding, these patients received a 10-minute infusion of placebo (normal saline) in a second infusion line, followed by a 15-minute observation period and a second 10-minute infusion of placebo if still in AF ...
The report generally describes 2-tert-butyl-4-(α-carbethoxytridecyloxy)-phenol, examines its uses, production methods, patents. 2-tert-Butyl-4-(α-carbethoxytridecyloxy)-phenol
Read about the chemical and physical properties of 8-tert-Butyl-5,6-dimethyl-8H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine. Get 8-tert-Butyl-5,6-dimethyl-8H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
Most of the ADCs currently in the market and in clinical development carry tubulin polymerization inhibitors such as T-DM1 and SGN-35 (Brentuximab vedotin; ref. 13). We synthesized a novel ADC with a topoisomerase I inhibitor, which has a different mechanism of action from tubulin polymerization inhibitors, and a novel self-immolative linker system using an aminomethylene (AM) moiety. Although other cleavable linker systems applied to SGN-35 (Brentuximab vedotin) and several ADCs release amino group-containing payloads, this AM self-immolative linker system is able to release DXd containing the hydroxyl group from DS-8201a. Moreover, this novel linker-payload system enables a reduction in the hydrophobicity of the ADC and helps increase its DAR. In the case of T-DM1, lysine conjugation and noncleavable systems are used, and it is quite a different system from DS-8201a. DS-8201a showed potent HER2-specific efficacy both in vitro and in vivo, and by drug conjugation maintained the functional ...
TY - JOUR. T1 - Vernakalant. T2 - Pharmacology, electrophysiology, safety and efficacy. AU - Naccarelli, Gerald V.. AU - Wolbrette, Deborah L.. AU - Samii, Soraya. AU - Banchs, Javier E.. AU - Penny-Peterson, Erica. AU - Stevenson, Robert. AU - Gonzalez, Mario D.. PY - 2008/5/1. Y1 - 2008/5/1. N2 - The development of new antiarrhythmic agents for the treatment of atrial fibrillation is advancing simultaneously on several fronts. The molecular structure of existing agents such as amiodarone is being modified in an attempt to improve safety and reduce adverse effects. Similarly, atrial-selective antiarrhythmic drugs are being developed to minimize the occurrence of ventricular proarrhythmia. One of these atrial-selective compounds is vernakalant, which has demonstrated efficacy in terminating atrial fibrillation when given intravenously. In addition, preliminary data suggest that it could also suppress recurrences when used orally. This paper reviews the pharmacology, electrophysiology, efficacy ...
The authors of the AVRO study also assert that, while both treatments were found to be safe and well tolerated, vernakalant had low proarrhythmic potential and provides a rapidly acting therapeutic alternative.. The research team, led by Professor John Camm from St. Georges University of London, conducted a randomized, double-blind, multicenter superiority trial in 254 adult patients with underlying cardiovascular disease, making certain antiarrhythmic drugs inappropriate for use. 116 patients in each group received at least one dose of the study drug. Approximately 30% of patients in both treatment arms had no AF episodes prior to the initial diagnosis, whereas one-third had at least three.. Those in the vernakalant study arm received a 10-minute infusion of 3 mg/kg followed by an additional 10-minute infusion of 2 mg/kg if needed after a 15-minute observation period. Amiodarone patients received a 60-minute infusion of 5 mg/kg followed by an additional 60-minute maintenance infusion of 50 ...
The process of producing styrene comprising the use of a solution of paranitrosophenol in n-methyl pyrollidone as a polymerization inhibitor during said process. A polymerization inhibitor system for monomers comprising a solution of a polymerization inhibitor in a solvent which is miscible with the feedstock for the monomer and the monomer. Dinitro-orthocresol works very well, but is extremely toxic. NAUGARD® SFR inhibitor by SI Group is a sterically hindered nitroxyl stable free radical. According to the report findings, the certificate of inhibitor, issued by the cargo surveyor at the time of loading, stated that the TBC should remain effective for between 60 and 90 days. It can be used when storing highly reactive monomers. TISP is based on the new principles of Inhibition. Specialty Chemicals HP. AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO ...
The first indication in determining the quality of wine is if there is presence of any faults. The more common ones include cork taint (TCA) and oxidation and can be detected when an aroma or flavor in the wine appears off or just wrong. Cork taint occurs when 2,4,6 - Tricloranisole or TCA, generated by naturally-occurring fungi that often exist in the crevices of wood or cork, comes into contact with chlorine compounds present in pesticides, cleaning agents, wood treatments, etc. When cork taint occurs, the wine will have a musty, moldy aroma. Controlling the source of TCA has proven extremely difficult and currently there are no solutions.. Another wine fault is the oxidation or reduction of the wine - which happens when wines are either exposed to too much or too little oxygen respectively. When oxidation occurs, this usually results in a breakdown of its attractive color. Whites go a dull brown/straw, rosés go brown/orange, reds become paler with an orange/brown rim. Chilling grapes and ...
The present study reports densities (ρ), viscosities (η) and ultrasonic speeds (U) of pure dioxane (DOX), anisole (ANS), toluene (TOL) and ethylbenzene (ETB) and their binary liquid mixtures over the entire composition range at 293, 298, 303, 308 and 313 K. From the experimental data excess molar volume (VmE), excess intermolecular free length (LfE), excess adiabatic compressibility (βE) and excess acoustic impedance (ZE) have been computed. The excess values were correlated using Redlitch-Kister polynomial equation to obtain their coefficients and standard deviations (σ). With increase in temperature, the binary mixture of DOX+ANS shows larger deviations in βE, LfE and smaller deviations in ZE, VmE. These results suggest that ANS has strong molecular interactions with DOX than ETB and TOL.
United States Patent C 3,766,288 PROCESS FOR PREPARATION OF ALKENYLBENZENE Takeo Shima, Takanori Urasaki, and Iwao Omae, Iwakuni, Japan, assignors to Teiiin Limited, Osaka, Ja an N3 Drawing. Filed Mar. 27, 1972, Ser. No. 238,584 Claims priority, application Japan, Mar. 29, 1971, 46/ 18,602 Int. Cl. C07c 3/52 U.S. Cl. 260-668 B 9 Claims ABSTRACT OF THE DISCLOSURE A process for preparing alkenylbenzenes, which comprises reacting alkylbenzenes with 1,3-butadiene at an elevated temperature in the presence of an alkali metal catalyst in the substantial absence of oxygen and mois ture, wherein such catalyst is composed of (1) 0.005 to 0.4% by weight, based on the alkylbenzene, of metallic potassium, and (2) metallic sodium in an amount expressed by the following equation (4.1x+2.0) ;Na;(0.073x+0.05) wherein x represents the amount in weight percent of the metallic potassium. This invention relates to an improved process for preparing alkenylbenzenes by reacting alkylbenzenes with 1,3- butadiene in the ...
Looking for anise? Find out information about anise. annual plant of the family Umbelliferae , native to the Mediterranean region but long cultivated elsewhere for its aromatic and medicinal qualities. Explanation of anise
Shop for organic, ground, or whole anise online. Free delivery from € 47,90. Sonnentor Organic Star Anise, Sonnentor Organic Anise, Cosmoveda Organic Star Anise, ground. Free Hotline: 0800 55 66 40 506.
Many would argue that the sense of smell is our far most important sense when it comes to evaluating wine. This is because the olfactory sense plays a fundamental role both in the perception of aroma and also flavour. Without it all wines,3 rather than just a few, would appear to be uninteresting alcoholic solutions of acid and sugar. The sense of smell is by far the most powerful of our senses. It can discriminate between tens of thousands of different aromas, and is capable of detecting some compounds found in wine at levels around a single part per trillion. An example of this is the compound 2,4,6 Trichloroanisole, the primary compound responsible for cork taint. Some people can detect it at around 1 part per trillion which is analogous to a single second in thirty two years. Not bad I suppose, but when you think that an Alsatian or Beagle probably sees a three dimensional colliedescope like scent world, our olfactory efforts seem pretty pathetic in comparison. The olfactory system ...
Hydroquinone cream can be found in Germany through the store called the Chemical point. Some of them include 2-(1-Phenylethyl) hydroquinone. Hydroquinone, pharma grade, Hydroquinone dimethyl ether (1, 4-Dimethoxybenzene) and many more. There are many online pharmacies and online stores that provide all kinds of medicines including Hydroquinone.. One tube will cost $12.99 and $35.99 for three tubes. Shopeastwest is another medicine center or online pharmacy that will provide you with all kinds of generic and cheap drugs. There are other stores like Melalong by Ajanta Pharma users who are worried and confused about without worrying about its quality or how to buy without becoming confused in complicated websites. Shopeastwest provides you with a quality or how to buy with being confused in complicated websites.. All the drugs from Shopeastwest are delivered by FDA certified pharmaceutical companies and are tested for quality. The user friendly nature of the website can provide you with the best ...
Email: [email protected] Web: http://www.an-gene.com/ Name CAS ID ETHYL PICOLINATE 2524-52-9 AG-E-76780 1-BROMO-2,5-DIMETHOXYBENZENE 25245-34-5 AG-E-76783 4-(4-MORPHOLINO)ANILINE 2524-67-6 AG-E-76788 BENZENE, ETHENYL-, DIMER 25247-68-1 AG-E-76794 POLYVINYLPYRROLIDONE CROSS-LINKED 25249-54-1 AG-E-76807 2-BROMO-5-IODOBENZOIC ACID 25252-00-0 AG-E-76822 DIPROPYLENE GLYCOL 25265-71-8 AG-E-76901 METHYL ALPHA ?BROMO-2-CHLORO-PHENYL ACETATE 25270-30-4 AG-E-76948 1-METHYL-PIPERIDINE-2-CARBOXYLIC ACID X HCL 25271-35-6 AG-E-76951 3-CHLOROMETHYL-1,2,4-TRIAZOLIN-5-ONE 252742-72-6 AG-E-76966 DIBUTYL PHENYL PHOSPHATE 2528-36-1 AG-E-77008 8-BROMO-5-NITRO-ISOQUINOLINE…
4-Tert-butyl-2-[(dimethylamino)methyl]-6-(prop-2-en-1-yl)phenol | C16H25NO | CID 223627 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
2-tert-butyl-6-(2-phenylpropan-2-yl)phenol | C19H24O | CID 577322 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Learn more about tert-butyl-4-5-bromo-1h-indol-3-yl-3-6-dihydro-1-2h-pyridinecarboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
Ampyridine offer gram to tons of CAS No.1428537-19-2, 2-[(4R)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]-5-(trifluoromethyl)pyridine,AM11903,purity 98% Min.,MSDS.
Learn more about tert-butyl-4-hydroxy-3-trifluoromethyl-piperidine-1-carboxylate. We enable science by offering product choice, services, process excellence and our people make it happen.
Pesticide properties for N-((8-tert-butyl-1,4-dioxaspiro(4.5)dec-2-yl)methyl)propan-1-amine, including approvals, environmental fate, eco-toxicity and human health issues
4-tert-butyl-3-methyl-phenol - Buyers Guide for Chemicals is a directory of chemicals, chemical suppliers and producers. More than 140,000 products, 270,000 supply sources and 4,400 company addresses. Search for free and find new suppliers for chemical products, pharmaceuticals and APIs.
2-tert-Butyl-7-fluoro-5-nitro-1H-indole/ACM952664947 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
Buy 5-tert-Butyl-2-[2-(4-fluoro-phenoxy)-ethyl]-2,4-dihydro-pyrazol-3-one (CAS 864685-46-1), a product for proteomics research, from Santa Cruz.
2-(1-tert-butyl-1H-pyrazol-4-yl)acetic acid; CAS Number: 1784925-12-7; find Enamine-ENAH03A0E8B0 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
2-tert-Butyl-1H-imidazole. CAS Number: 36947-69-0. Catalog Number: AA003HUZ. MDL Number: MFCD16618480. Molecular Formula: C7H12N2. Molecular Weight: 124.1836. AA Blocks.
chemBlink provides information about CAS # 152828-25-6, 2-(4-Aminophenyl)-6-tert-butyl-1H-pyrazolo[1,5-b][1,2,4]triazole, molecular formula: C12H11N5.
The test item consisted of non-transparent particles which had a very strong tendency for agglomeration. The particles had a sticky behaviour and were electrostatically charged after sieving. A large part of the test item was present in form of agglomerates with a diameter above 1 mm. The aforementioned effects opposed a measurement via sieve analysis and influenced the results of the study using laser diffraction. Hence, the test item was sieved with a mesh size of 1000 µm. Only 43% (w/w) of the test item passed the sieve and only this fraction was measured with laser diffraction. Median particle size D (v, 0.5): 50% of particle volume or particle mass with lower particle diameter 1st test series: 11.8 µm 2nd test series: 13.9 µm Average of median particle size: 12.8 µm Particle size D (v, 0.1): 10% of particle volume or particle mass with lower particle diameter 1st test series: 3.8 µm 2nd test series: 4.2 µm Average of the particle size: 4.0 µm Particle size D (v, 0.9): 90% of particle ...
For example, synthetic anethole is prepared from anisole. Anisole is relatively nontoxic with an LD50 of 3700 mg/kg in rats. ... For example, P4S10 converts anisole to Lawesson's reagent, [(CH3OC6H4)PS2]2. Also indicating an electron-rich ring, anisole ... from Anisole". Organic Syntheses. 57: 107. doi:10.15227/orgsyn.057.0107. G. S. Hiers and F. D. Hager (1929). "Anisole". Organic ... CH3I Birch reduction of anisole gives 1-methoxycyclohexa-1,4-diene. Anisole is prepared by methylation of sodium phenoxide with ...
... is the organophosphorus compound with the formula (C6H5)2PC6H4-2-OCH3. It is a white solid that is ... Reactivity and Structure of Dichlorobis(o-(diphenylphosphino)anisole)ruthenium(II)". Inorganic Chemistry. 18: 2658. doi:10.1021 ...
Hiers, G. S. (1929). "Anisole". Organic Syntheses. 9: 12. doi:10.15227/orgsyn.009.0012. Icke, Roland N.; Redemann, Ernst; ... A wide variety of phenols undergo O-methylation to give anisole derivatives. This process, catalyzed by enzymes such as ...
Anisole is formally known as methoxybenzene, and is formed through the condensation of methanol (CH3OH) and phenol; due to the ... Anisole (C6H5OCH3) is the simplest phenol ether, and is a versatile precursor for perfumes and pharmaceuticals. Vanillin and ... "Anisole". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-03-29. Lipinski, Christopher A. (December 2004). "Lead- and drug-like ... compared to 3500-4000 mg/kg for anisole, the methyl ether. Furthermore, ethers are significantly more hydrophobic than phenols ...
G. S. Hiers and F. D. Hager (1941). "Anisole". Organic Syntheses.; Collective Volume, vol. 1, p. 58 H. Perst; D. G. Seapy (2008 ...
Anisole Stille, J. K.; Echavarren, Antonio M.; Williams, Robert M.; Hendrix, James A. (1993). "4-Methoxy-4'-Nitrobiphenyl". ...
Anisole "BHA and BHT". Retrieved Nov 20, 2009. "SciFinder - Experimental properties for 121-00-6". Retrieved Nov 20, 2009. ...
PhOH + NaOH -----> Ph-O-Na Ph-O-Na + Et2SO4 ------> Ph-O-Et This reaction follows Sn2 path.[citation needed] Anisole "Phenetole ...
... better-known as anisole, and water, which is not shown in the diagram. Anisole is listed as an acute hazard to aquatic life ... Balsama et al 1984 "Anisole". PubChem Database. National Center for Biotechnology Information. Retrieved April 7, 2019. Clarke ...
"Biohalogenation as a source of halogenated anisoles in air". Chemosphere. 22 (5-6): 557-567. Bibcode:1991Chmsp..22..557W. doi: ...
Triphenylphosphine 2-(Diphenylphosphino)anisole Evans, D.; Osborn, J. A.; Wilkinson, G. (1968). "Hydroformylation of alkenes by ...
Anisole converts to cresols under these conditions. Cresols are precursors or synthetic intermediates to other compounds and ...
Wiechell, H. (1894). "Condensation des Dichloracetals mit Anisol und Phenetol". Justus Liebig's Annalen der Chemie. 279 (3): ...
Other methoxy ethers include anisole and vanillin. Many alkoxides contain methoxy groups, e.g. tetramethyl orthosilicate and ...
Both anisole and pentamethylbenzene have been reported as intermediates in the process. Valentin Koptyug and co-workers found ... Formation of anisole, methylated phenols, and hexamethylbenzene". J. Chem. Soc.: 821-823. doi:10.1039/JR9450000821. PMID ... though as part of a complex mixture of anisole (methoxybenzene), cresols (methylphenols), and other methylated phenols. An ...
Methyl phenyl ether is anisole, because it was originally found in aniseed. The aromatic ethers include furans. Acetals (α- ... Illustrative unsymmetrical ethers are anisole (methoxybenzene) and dimethoxyethane. Vinyl- and acetylenic ethers are far less ...
2-Anisaldehyde is prepared commercially by formylation of anisole. A. J. Sisti (1964). "o-Anisaldehyde". Org. Synth. 44: 4. doi ...
Glycerol and acetic acid are examples of retained semisystematic names; furan and anisole are examples of retained trivial ...
Deblocking with aluminium chloride and anisole gives moxalactam 14. Weitekamp MR, Aber RC (1983). "Prolonged bleeding times and ...
... scavengers such as anisole or thioanisole may be used. Selective cleavage of the N-Boc group in the presence of other ...
... scavengers such as anisole or thioanisole may be used. Selective cleavage of the N-Boc group in the presence of other ...
doi:10.1016/0040-4020(59)85008-0. Burnham, D. R. (1969). "Orientation in the mechanism of the Birch reduction of anisole". ... Electron donors tend to induce ortho protonation, as shown in the reduction of anisole (1). Electron-withdrawing substituents ...
Synthetic applications: Experimental procedure with anisole and methylbenzoate Zeisel, S (1885). "Über ein Verfahren zum ...
... anisole" (PDF). Journal of Physical Organic Chemistry. 25 (10): 878-882. doi:10.1002/poc.2939. Chen, Chen; Ke, Jiyuan; Zhou, X ...
The transfer of positive ions, such as protons and charge transfers, are seen with the solvents: toluene and anisole. Toluene ... Some of the common solvents include: nitrogen, toluene, acetone, and anisole. The desorption process can occur by two ...
"Gas-phase reaction of free isopropyl ions with phenol and anisole". (1980) "Aromatic substitution in the gas phase. A ... "Gas-phase reaction of free isopropyl ions with phenol and anisole". Journal of the Chemical Society, Perkin Transactions 2, ...
It has an anisole (methoxybenzene) core, with two nitro groups (-NO2) attached. It is not explosive itself unless it is mixed ...
The male attractant pheromone, anisole was identified from abdominal glands of females. Anisole is also the sex pheromone of ...
It is prepared commercially from 4-methoxypropiophenone, which is prepared from anisole. Anethole is distinctly sweet, ... On the constitution of anisol (anethol)]. Zeitschrift für Chemie. 2nd Series (in German). 2: 472-474. Media related to Anethole ...
... is obtained by Birch reduction of anisole followed by acid hydrolysis. It can be obtained from cyclohexanone by α ...
A meta description is an HTML tag in the HTML code of your website, which allows you to customize a section of text that describes the page itself. It plays a role in how your page is seen by search engine crawlers, and how it appears in SERPs
The global Anisole market is expected to showcase a significant CAGR of 5.3% during the forecasted period 2018-2027. ... Anisole Overview. Anisole, also known as methoxybenzene can be defined as an organic compound and colorless liquid with smell ... The chemical formula of anisole is CH3OC6H5. Anisole has a good solubility in diethyl ether, ethanol, benzene, chloroform, ... Asia Pacific Anisole market captured significant share of global Anisole market in previous years. Advancement in technology ...
2022 PGL Chemie, Kiev, Ukraine ...
... Publikováno 14.11.2020 , Autor: [22] [23] More modern RHF computations lead to the same result. Are ... These steps are outlined below for the case of anisole. By using our site, you acknowledge that you have read and understand ... H. E. Zimmerman and P. A. Wang, J. English: Birch reduction of Anisole. [6]. In 1961 a simple computation of the electron ... isomeric transition states for protonation of the radical anion intermediate in the Birch reduction of anisole. EDGs are ...
We study suspended graphene in contact with the organic molecule anisole to analyse the implications of the interaction for the ... Upadhyay Kahaly, M., & Schwingenschlögl, U. (2014). Enhanced solar light absorption of graphene by interaction with anisole. ...
... anisole. 1049730-84-8 MSDS,ROS,1049730-84-8 MOA,COA,SPECS,pecifications,1H-NMR,GHS,CAT #31155 ... For more information, please view Spec of 4-Bromo-3-(trifluoromethoxy)anisole 1049730-84-8.pdf. ...
Anisoles / toxicity * Benzaldehydes / toxicity * Cell Survival / drug effects * Electronic Nicotine Delivery Systems* ...
Das, P.R.; Gilman, J.P.; Meisels, G.G., Unimolecular decomposition of energy-selected anisole ions. Breakdown graph and ...
Isoeugenyl ethyl ether; 2-ethoxy-5-propenyl-anisole; ethyl isoeugenol. Isoeugenyl formate. ...
Anisol wurde mit polaren und unpolaren kleinen aromatischen Systemen als Cluster-Partner versetzt und mittels ReMPI untersucht ...
Capillary Column Studies of Chlorinated Anisoles, J. Chromatogr., 1984, 294, 99-116, https://doi.org/10.1016/S0021-9673(01) ...
With sodium 1.) anisole, 110 deg C, 2.) 24 h; Yield given. Multistep reaction;. ...
First, 100 μL hydroxy anisole (BHA) was chosen to be a positive control. Then, 2.5 μL of the sample solutions of different ...
the anisole derivative 1 to the phenol 2. Melanie S. Sanford of the University of Michigan devised (Org. Lett. 2013, 15, 5428. ...
Anisole market outlook The Anisole Market analysis and outlook report presents forecasts by Type, Application, country, and ... Anisole Market Growth Opportunities, 2023 - Market Insights, Mega Trends, Companies, and Forecasts to 2030 * $ 4880 ...
Friedel-Crafts alkylation of anisole in supercritical carbon dioxide: A comparative study of catalysts Organic Process Research ... Friedel-Crafts alkylation of anisole in supercritical carbon dioxide: a catalyst comparative study of catalysts Organic Process ...
A novel heterogeneously catalyzed solvent-free process for the acylation of anisole with acetic anhydride. Matthias Eisenacher ...
Global Anisole Market Report and Forecast 2023-2028. * Email Delivery * Price: $ 1499 ...
P-ALLYL ANISOLE 1 spectrum C10H12O Generated by the Chemistry Development Kit (http://github.com/cdk). \n. 148.08882 ...
... butylated hydroxy anisole, mannitol, low-substituted hydroxypropyl cellulose, sodium stearyl fumarate.. ...
Broad process development experience and technological expertise enables DOTTIKON EXCLUSIVE SYNTHESIS AG to offer high-quality chemicals and intermediates.
anisole. ailment. ammines. anomies. amotion. almsmen. aliment. amities. atonies. amosite. entasis. entails. emotion. elastin. ... anisoles. alienist. alienism. animists. atomisms. amotions. amitoses. ailments. animisms. amosites. amitosis. aliments. ...
C. and treat with anisole (2mL, 7.8mmol) and then trifluoracetic acid (8mL). Stir for 2 hour under nitrogen atmosphere, ... and treat with anisole (150 .mu.L, 1.38mmol) and trifluoroacetic acid (0.8mL, 10.4mmol). Stir for 3.25 hours at room ... and treat with anisole (150 .mu.L, 1.38mmol) and trifluoroacetic acid (0.8mL, 10.4mmol). Stir for 3.25 hours at room ... and treat with anisole (150 .mu.L, 1.38mmol) and trifluoroacetic acid (0.8mL, 10.4mmol). Stir for 3.25 hours at room ...
Results also showed that anisole (EO extracted from Apiaceae) was not only effective against A. suspensa via contact, but also ...
  • Anisole is prepared synthetically and is a pioneer of other synthetic compounds and it is ether. (researchnester.com)
  • Anisole has a good solubility in diethyl ether, ethanol, benzene, chloroform, toluene and most of the organic solvents. (researchnester.com)
  • 5. Production of methyl isocyanate, carbamate drugs, anisole. (sinochemi.com)
  • Anisole market outlook The Anisole Market analysis and outlook report presents forecasts by Type, Application, country, and companies. (reportlinker.com)
  • The global anisole market is segmented on the basis of purity, application and geography. (researchnester.com)
  • To conclude, we characterise two (of the four) isomeric transition states for protonation of the radical anion intermediate in the Birch reduction of anisole. (pitbikemoravia.cz)
  • The global Anisole market is expected to showcase a significant CAGR of 5.3% during the forecasted period 2018-2027. (researchnester.com)
  • Additionally, the global Anisole market is thriving on the back rapid industrialization along with rising use of intermediate chemicals for manufacturing of other products such as polycarbonates, and detergents is expected to promote the expansion of capacity over the forecast period. (researchnester.com)
  • Increasing consumption of cosmetic products such as perfumes is expected to increase the market size of anisole over the forecast period. (researchnester.com)
  • In terms of regional platform, Europe Anisole market is projected to lead the growth of overall global Anisole market over the forecast period. (researchnester.com)
  • Further, France, Germany, and the U.K are expected to contribute significantly in the growth of Anisole market in Europe region during the predicted period. (researchnester.com)
  • Asia Pacific Anisole market captured significant share of global Anisole market in previous years. (researchnester.com)
  • Advancement in technology and rising disposable income are key factors which are driving the growth of anisole market in Asia Pacific region. (researchnester.com)
  • H. E. Zimmerman and P. A. Wang, J. English: Birch reduction of Anisole. (pitbikemoravia.cz)
  • Results also showed that anisole (EO extracted from Apiaceae) was not only effective against A. suspensa via contact, but also showed strong fumigation and residue effects. (usda.gov)
  • Particularly, compound 2 possesses a closed ionophoric cavity: the upper hemisphere is closed by three ten-butyl groups of anisole units and the lower hemisphere is closed by a mesitylene cap and three anisole methoxy groups. (elsevier.com)
  • Combined studies of 2 and 3 by MM3 computation, X-ray analysis, and 1 H NMR spectroscopy established that these calix[6]arenes feature a unique structure consisting of alternately-arranged three flattened mesitylene-linked phenyl units and three stand-up anisole units. (elsevier.com)
  • Analoog zijn de adsorptiecoëfficiënten van anisol en de primaire producten, fenol en cresol, ook statistisch significant. (scriptiebank.be)
  • The oxygenates in question, anisole, benzyl alcohol and 2-phenyl ethanol, have similar heating values and cetane numbers, but differ in the position of the functional oxygen group relative to the aromatic ring. (sae.org)
  • Factors such as, high awareness amongst the population regarding benefits of using Anisole such as manufacturing nanoparticles (tin oxide) and inorganic complexes, has resulted in an increasing demand for anisole. (researchnester.com)
  • The top priority of our organization is to achieve utmost customer satisfaction by manufacturing and exporting a quality assured range of Meta Bromo Anisole . (suryalifesciencesltd.com)
  • Packed by using quality approved packaging materials, our Meta Bromo Anisole is offered at the pocket friendly prices. (suryalifesciencesltd.com)
  • Our company offers m - Bromo Anisole that is used as chemical intermediate It is a light yellow liquid that is formulated in our production unit in strict compliance with international quality norms. (suryalifesciencesltd.com)
  • Wholesale Trader of a wide range of products which include industrial anisole and industrial bromo anisole. (neshiel.in)
  • Clarion Drugs Ltd offers a wide range of products which includes 3-bromo anisole. (cphi-online.com)
  • The Anisole is likewise recognized as Methoxybenzene. (express-press-release.net)
  • Anisole, also known as methoxybenzene can be described as an organic compound and colourless liquid with smell similar to that of anise seed. (worldwidemarketreports.com)
  • Anisole, (aka methoxybenzene) is one of the essential oils that give licorice its flavor and scent. (acsh.org)
  • Here's a concrete example: the nitration of methoxybenzene (also known as anisole). (masterorganicchemistry.com)
  • Cancer cells possess the next seven particular properties: 1) self-sufficiency in development indicators, 2) insensitivity to anti-growth indicators, 3) evasion of apoptosis, 4) unlimited replicative potential (the telomerase and Anisole Methoxybenzene telomere pathway), 5) suffered angiogenesis, 6) cells invasion and metastasis, and 7) genome instability.5,6 Generally, tumors are classified based on the differentiated component. (bollywooddvds.com)
  • Phase 1 enzymes such as CYP2D6 and CYP3A4 catalyze the oxidation of anisole to phenol. (acsh.org)
  • Upon consumption, anisole is converted by cytochrome P450 (CYP) enzymes to phenol (3) as shown in Figure 1. (acsh.org)
  • With no catalyst present, anisole hydrolyzes to phenol in 97% yield after 24 hours at 365 °C, our experimentally determined optimal temperature and time. (usaigcnj.com)
  • Electrophilic Fukui analysis was applied to anisole and phenol molecules to determine their reactivity to carbocation attack in catalytic reactions. (usaigcnj.com)
  • Anisole has a good solubility in diethyl ether, ethanol, benzene, chloroform, toluene and most of the organic solvents. (worldwidemarketreports.com)
  • Three different atmospheric pressure ionization (API) techniques, including photoionization (APPI) with four different dopants (acetone, anisole, chlorobenzene and toluene), heated electrospray ionization (HESI) and atmospheric pressure chemical ionization (APCI), were evaluated on the basis of method detection limits (MDLs) and recoveries from different aqueous matrixes. (nih.gov)
  • Haken, J.K., Dispersion and selectivity indices of the halogenated derivatives of cyclohexane, benzene and anisole, J. Chromatogr. (chemspider.com)
  • Anisole is prepared synthetically and is a precursor of other synthetic compounds and it is an ether. (worldwidemarketreports.com)
  • The COSMOSIL PE-MS shows slightly longer retention time for compounds such as nitrobenzenes, which have electron acceptors, or electron donor compounds (such as anisole). (sesres.com)
  • The global Anisole Market is anticipated to reach USD 54.9 million by 2022 and is expected to witness significant growth at a substantial CAGR for the duration of the prediction. (express-press-release.net)
  • Anisole Market Reaching A Value Worth USD $54.9 Million By 2022: Grand View Research, Inc. (augustaheadlines.com)
  • The rates of deuterium-protium exchange have been determined for o-, m- and p-deuterated fluorobenzene, benzotri-fluoride and anisole in liquid ammonia solution in the presence of potassium amide. (caltech.edu)
  • Mechanism of Hydroxyl Radical-Induced Breakdown of the Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4-D). If you are the author of this article you still need to obtain permission to reproduce Computational Study on Kinetics of Conversion of Bio-oil Model Compound - Anisole, to Platform Chemicals. (usaigcnj.com)
  • As lignin has a very complex structure, anisole was used as a model compound. (undip.ac.id)
  • Zn(II) binding to such a probe consisting of a tris(picolyl)amine-substituted acceptor site connected with an anisole donor moiety and an oxazole central core resulted in a significant increase of the two-photon absorption cross section (δ) and fluorescence brightness (ηδ). (edu.sa)
  • Because many aromatic species fluoresce in the same spectral region as SO2 , fluorescence spectra were also measured for naphthalene and anisole to determine if ambient SO2 measurements could be biased in the presence of such species. (nasa.gov)
  • Industrial Anisole , is an organic compound. (neshiel.in)
  • Methoxychlor was first synthesized in 1893 by the reaction of chloral hydrate with anisole in the presence of acetic acid and sulfuric acid. (cdc.gov)
  • Kinetic analysis and reaction mechanism for anisole conversion over zirconia-supported molybdenum oxide, https://doi.org/10.1016/j.jcat.2019.06.046. (usaigcnj.com)
  • Robust basis of the production of the scent products, combined with the growing demand in the nations such as Saudi Arabia, Brazil, Mexico, Germany, and the U.S.A, are estimated to motivate the anisole industry. (express-press-release.net)
  • Necessity of these products in greater quantities drives the anisole market in a big measure even in emerging nations. (express-press-release.net)
  • By the source of geography, the Europe is responsible for a bigger stake in the anisole industry and will display development in the U.K., Germany and France, as the necessity for cosmetic products are growing speedily. (express-press-release.net)
  • It was found that the use Pt-containing catalysts based on hypercrosslinked polystyrene in both processes of anisole and lignin-containing feedstock conversion allowed obtaining the highest yield of oxygen-free hydrocarbons (up to 96 wt. (undip.ac.id)
  • The company was incorporated in 2003, and within 17 years of incorporation the company has grown to be the largest manufacturer globally of MEHQ, BHA, Anisole and 4-MAP, in terms of installed manufacturing capacities as of March 31, 2021. (5paisa.com)
  • The obtainability of the raw material and instability of the price continue as some of the biggest encounters in the anisole industry. (express-press-release.net)