Anion Transport Proteins
Anion Exchange Protein 1, Erythrocyte
A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.
Organic Anion Transport Polypeptide C
Organic Anion Transport Protein 1
Membrane Transport Proteins
Fatty Acid Transport Proteins
Biological Transport, Active
The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.
Organic Anion Transporters
Monosaccharide Transport Proteins
Organic Anion Transporters, Sodium-Independent
Cation Transport Proteins
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Electroneutral chloride bicarbonate exchangers that allow the exchange of BICARBONATE IONS exchange for CHLORIDE IONS across the cellular membrane. The action of specific antiporters in this class serve important functions such as allowing the efficient exchange of bicarbonate across red blood cell membranes as they passage through capillaries and the reabsorption of bicarbonate ions by the kidney.
Amino Acid Sequence
Kidney Tubules, Proximal
Multidrug Resistance-Associated Proteins
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.
ATP-Binding Cassette Transporters
Cell Membrane Permeability
The major sialoglycoprotein of the human erythrocyte membrane. It consists of at least two sialoglycopeptides and is composed of 60% carbohydrate including sialic acid and 40% protein. It is involved in a number of different biological activities including the binding of MN blood groups, influenza viruses, kidney bean phytohemagglutinin, and wheat germ agglutinin.
Cystic Fibrosis Transmembrane Conductance Regulator
A phylum of microscopic ecdysozoan invertebrates, closely related to ARTHROPODS. Members exhibit anabiosis and cryptobiosis, dormant states where metabolic activity is reduced or absent, thus making them tolerant to extreme environmental conditions. They are distributed worldwide and most are semi-aquatic.
Vesicular Transport Proteins
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. They play a role in the intracellular transport of molecules contained within membrane vesicles. Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Glucose Transport Proteins, Facilitative
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Amino Acid Transport Systems
Electrophoresis, Polyacrylamide Gel
Organic Cation Transport Proteins
A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Nucleotide Transport Proteins
A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies.
A greenish-yellow, diatomic gas that is a member of the halogen family of elements. It has the atomic symbol Cl, atomic number 17, and atomic weight 70.906. It is a powerful irritant that can cause fatal pulmonary edema. Chlorine is used in manufacturing, as a reagent in synthetic chemistry, for water purification, and in the production of chlorinated lime, which is used in fabric bleaching.
An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
Nucleoside Transport Proteins
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Voltage-Dependent Anion Channels
Sequence Homology, Amino Acid
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Dose-Response Relationship, Drug
Acidosis, Renal Tubular
A group of genetic disorders of the KIDNEY TUBULES characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic ACIDOSIS. Defective renal acidification of URINE (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as HYPOKALEMIA, hypercalcinuria with NEPHROLITHIASIS and NEPHROCALCINOSIS, and RICKETS.
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
Periplasmic Binding Proteins
An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Voltage-Dependent Anion Channel 1
A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Dicarboxylic Acid Transporters
Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.
Rats, Inbred Strains
Equilibrative Nucleoside Transport Proteins
Amino Acid Transport Systems, Basic
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
Amino Acid Transport Systems, Neutral
Active Transport, Cell Nucleus
Vesicular Biogenic Amine Transport Proteins
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
GABA Plasma Membrane Transport Proteins
A family of plasma membrane neurotransmitter transporter proteins that regulates extracellular levels of the inhibitory neurotransmitter GAMMA-AMINOBUTYRIC ACID. They differ from GABA RECEPTORS, which signal cellular responses to GAMMA-AMINOBUTYRIC ACID. They control GABA reuptake into PRESYNAPTIC TERMINALS in the CENTRAL NERVOUS SYSTEM through high-affinity sodium-dependent transport.
Chromatography, High Pressure Liquid
Recombinant Fusion Proteins
Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. (1/811)The canalicular multispecific organic anion transporter (cMOAT), a member of the ATP-binding cassette transporter family, mediates the transport of a broad range of non-bile salt organic anions from liver into bile. cMOAT-deficient Wistar rats (TR-) are mutated in the gene encoding cMOAT, leading to defective hepatobiliary transport of a whole range of substrates, including bilirubin glucuronide. These mutants also have impaired hepatobiliary excretion of GSH and, as a result, the bile flow in these animals is reduced. In the present work we demonstrate a role for cMOAT in the excretion of GSH both in vivo and in vitro. Biliary GSH excretion in rats heterozygous for the cMOAT mutation (TR/tr) was decreased to 63% of controls (TR/TR) (114+/-24 versus 181+/-20 nmol/min per kg body weight). Madin-Darby canine kidney (MDCK) II cells stably expressing the human cMOAT protein displayed >10-fold increase in apical GSH excretion compared with wild-type MDCKII cells (141+/-6.1 pmol/min per mg of protein versus 13.2+/-1.3 pmol/min per mg of protein in wild-type MDCKII cells). Similarly, MDCKII cells expressing the human multidrug resistance protein 1 showed a 4-fold increase in GSH excretion across the basolateral membrane. In several independent cMOAT-transfectants, the level of GSH excretion correlated with the expression level of the protein. Furthermore, we have shown, in cMOAT-transfected cells, that GSH is a low-affinity substrate for the transporter and that its excretion is reduced upon ATP depletion. In membrane vesicles isolated from cMOAT-expressing MDCKII cells, ATP-dependent S-(2,4-dinitrophenyl)glutathione uptake is competitively inhibited by high concentrations of GSH (Ki approximately 20 mM). We concluded that cMOAT mediates low-affinity transport of GSH. However, since hepatocellular GSH concentrations are high (5-10 mM), cMOAT might serve an important physiological function in maintenance of bile flow in addition to hepatic GSH turnover. (+info)
Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. (2/811)Dubin-Johnson syndrome (DJS) is an autosomal recessive disease characterized by conjugated hyperbilirubinemia. Previous studies of the defects in the human canalicular multispecific organic anion transporter gene (MRP2/cMOAT) in patients with DJS have suggested that the gene defects are responsible for DJS. In this study, we determined the exon/intron structure of the human MRP2/cMOAT gene and further characterized mutations in patients with DJS. The human MRP2/cMOAT gene contains 32 exons, and it has a structure that is highly conserved with that of another ATP-binding-cassette gene, that for a multidrug resistance-associated protein. We then identified three mutations, including two novel ones. All mutations identified to date are in the cytoplasmic domain, which includes the two ATP-binding cassettes and the linker region, or adjacent putative transmembrane domain. Our results confirm that MRP2/cMOAT is the gene responsible for DJS. The finding that mutations are concentrated in the first ATP-binding-cassette domain strongly suggests that a disruption of this region is a critical route to loss of function. (+info)
Immunohistochemical localization of multispecific renal organic anion transporter 1 in rat kidney. (3/811)Renal proximal convoluted tubules have an important role, i.e., to excrete organic anions, including numerous drugs and endogenous substances. Recently, multispecific organic anion transporter 1 (OAT1) was isolated from rat kidney. In this study, the cellular and subcellular localization of OAT1 in rat kidney was investigated. Kidneys from normal rats were perfused and fixed with periodate-lysine-paraformaldehyde solution and were then processed for immunohistochemical analysis using the labeled streptavidin-biotin method, preembedding horseradish peroxidase method, and immunogold method. Light microscopic examination revealed immunostaining for OAT1 in the middle portion of the proximal tubule (S2 segment), but not in the initial portion of the proximal convoluted tubule, next to the glomerulus. Nephron segments other than the S2 segment and the renal vasculature were not stained with antibody to OAT1. Electron-microscopic observation using a preembedding method revealed that OAT1 was exclusively expressed in the basolateral membrane of S2 segments of proximal tubules. The immunogold method showed no labeling for OAT1 in the cytoplasmic vesicles, suggesting that OAT1 may not move together with organic anions into the cells. These results are consistent with previous physiologic data showing that organic anions, including para-aminohippurate, are taken up by the basolateral Na+-independent organic anion/dicarboxylate exchanger and excreted at S2 segments. In conclusion, OAT1 was localized to the basolateral membrane of S2 segments of proximal tubules in rat kidneys. (+info)
Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2). (4/811)The rabbit polyclonal antibody against rat organic anion transporting polypeptide 2 (oatp2) was raised and immunoaffinity-purified. Western blot analysis for oatp2 detected two bands ( 74 and 76 kDa) in rat brain and a single band (76 kDa) in the liver. By immunohistochemical analysis, the oatp2 immunoreactivity was specifically high at the basolateral membrane of rat hepatocytes. Functionally, the oatp2-expressing oocytes were found to transport dehydroepiandrosterone sulfate, delta1 opioid receptor agonist [D-Pen2,D-Pen5]enkephalin, Leuenkephalin, and biotin significantly, as well as the substrates previously reported. These data reveal the exact distribution of the rat oatp2 at the protein level in the liver, and that oatp2 appears to be involved in the multispecificity of the uptaking substrates in the liver and brain. (+info)
Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. (5/811)The rat liver organic anion transporting polypeptide (Oatp1) has been extensively characterized mainly in the Xenopus laevis expression system as a polyspecific carrier transporting organic anions (bile salts), neutral compounds, and even organic cations. In this study, we extended this characterization using a mammalian expression system and confirm the basolateral hepatic expression of Oatp1 with a new antibody. Besides sulfobromophthalein [Michaelis-Menten constant (Km) of approximately 3 microM], taurocholate (Km of approximately 32 microM), and estradiol- 17beta-glucuronide (Km of approximately 4 microM), substrates previously shown to be transported by Oatp1 in transfected HeLa cells, we determined the kinetic parameters for cholate (Km of approximately 54 microM), glycocholate (Km of approximately 54 microM), estrone-3-sulfate (Km of approximately 11 microM), CRC-220 (Km of approximately 57 microM), ouabain (Km of approximately 3,000 microM), and ochratoxin A (Km of approximately 29 microM) in stably transfected Chinese hamster ovary (CHO) cells. In addition, three new substrates, taurochenodeoxycholate (Km of approximately 7 microM), tauroursodeoxycholate (Km of approximately 13 microM), and dehydroepiandrosterone sulfate (Km of approximately 5 microM), were also investigated. The results establish the polyspecific nature of Oatp1 in a mammalian expression system and definitely identify conjugated dihydroxy bile salts and steroid conjugates as high-affinity endogenous substrates of Oatp1. (+info)
Transcriptional regulation of molybdoenzyme synthesis in Escherichia coli in response to molybdenum: ModE-molybdate, a repressor of the modABCD (molybdate transport) operon is a secondary transcriptional activator for the hyc and nar operons. (6/811)Escherichia coli growing under anaerobic conditions produces several molybdoenzymes, such as formate hydrogenlyase (formate to H2 and CO2; hyc and fdhF genes) and nitrate reductase (narGHJI genes). Synthesis of these molybdoenzymes, even in the presence of the cognate transcriptional activators and effectors, requires molybdate in the medium. Besides the need for molybdopterin cofactor synthesis, molybdate is also required for transcription of the genes encoding these molybdoenzymes. In E. coli, ModE was previously identified as a repressor controlling transcription of the operon encoding molybdate transport components (modABCD). In this work, the ModE protein was also found to be a required component in the activation of hyc-lacZ to an optimum level, but only in the presence of molybdate. Mutant ModE proteins which are molybdate-independent for repression of modA-lacZ also restored hyc-lacZ expression to the wild-type level even in the absence of molybdate. Nitrate-dependent enhancement of transcription of narX-lacZ was completely abolished in a modE mutant. Nitrate-response by narG-lacZ and narK-lacZ was reduced by about 50% in a modE mutant. DNase I footprinting experiments revealed that the ModE protein binds the hyc promoter DNA in the presence of molybdate. ModE-molybdate also protected DNA in the intergenic region between narXL and narK from DNase I hydrolysis. DNA sequences (5' TAYAT 3' and 5' GTTA 3') found in ModE-molybdate-protected modABCD operator DNA were also found in the ModE-molybdate-protected region of hyc promoter DNA (5' GTTA-7 bp-CATAT 3') and narX-narK intergenic region (5' GTTA-7 bp-TACAT 3'). Based on these results, a working model is proposed in which ModE-molybdate serves as a secondary transcriptional activator of both the hyc and narXL operons which are activated primarily by the transcriptional activators, FhlA and NarL, respectively. (+info)
A spliced variant of AE1 gene encodes a truncated form of Band 3 in heart: the predominant anion exchanger in ventricular myocytes. (7/811)The anion exchangers (AE) are encoded by a multigenic family that comprises at least three genes, AE1, AE2 and AE3, and numerous splicoforms. Besides regulating intracellular pH (pHi) via the Cl-/HCO3- exchange, the AEs exert various cellular functions including generation of a senescent antigen, anchorage of the cytoskeleton to the membrane and regulation of metabolism. Most cells express several AE isoforms. Despite the key role of this family of proteins, little is known about the function of specific AE isoforms in any tissue, including the heart. We therefore chose isolated cardiac cells, in which a tight control of pHi is mandatory for the excitation-contraction coupling process, to thoroughly investigate the expression of the AE genes at both the mRNA and protein levels. RT-PCR revealed the presence of AE1, AE2 and AE3 mRNAs in both neonatal and adult rat cardiomyocytes. AE1 is expressed both as the erythroid form (Band 3 or eAE1) and a novel alternate transcript (nAE1), which was more specifically characterized using a PCR mapping strategy. Two variants of AE2 (AE2a and AE2c) were found at the mRNA level. Cardiac as well as brain AE3 mRNAs were expressed in both neonatal and adult rat cardiomyocytes. Several AE protein isoforms were found, including a truncated form of AE1 and two AE3s, but there was no evidence of AE2 protein in adult rat cardiomyocytes. In cardiomyocytes transfected with an AE3 oligodeoxynucleotide antisense, AE3 immunoreactivity was dramatically decreased but the activity of the Cl-/HCO3- exchange was unchanged. In contrast, intracellular microinjection of blocking anti-AE1 antibodies inhibited the AE activity. Altogether, our findings suggest that a specific and novel AE1 splicoform (nAE1) mediates the cardiac Cl-/HCO3- exchange. The multiple gene and protein expression within the same cell type suggest numerous functions for this protein family. (+info)
Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. (8/811)Recent studies show that organic anion secretion in renal proximal tubule is mediated by distinct sodium-dependent and sodium-independent transport systems. Here we investigated the possibility that organic anions entering the cells on one system can exit into the lumen on a transporter associated with the other system. In isolated rat kidneys perfused with 10 microM lucifer yellow (LY, a fluorescent organic anion) plus 100 micrograms/ml inulin, the LY-to-inulin clearance ratio averaged 1.6 +/- 0.2, indicating net tubular secretion. Probenecid significantly reduced both LY clearance and LY accumulation in kidney tissue. In intact killifish proximal tubules, confocal microscopy was used to measure steady-state LY uptake into cells and secretion into the tubular lumen. Probenecid, p-aminohippurate, and ouabain nearly abolished both uptake and secretion. To this point, the data indicated that LY was handled by the sodium-dependent and ouabain-sensitive organic anion transport system. However, leukotriene C4, an inhibitor of the luminal step for the sodium-independent and ouabain-insensitive organic anion system, reduced luminal secretion of LY by 50%. Leukotriene C4 did not affect cellular accumulation of LY or the transport of fluorescein on the sodium-dependent system. A similar inhibition pattern was found for another fluorescent organic anion, a mercapturic acid derivative of monochlorobimane. Thus, both organic anions entered the cells on the basolateral transporter for the classical, sodium-dependent system, but about half of the transport into the lumen was handled by the luminal carrier for the sodium-independent system, which is most likely the multidrug resistance-associated protein. This is the first demonstration that xenobiotics can enter renal proximal tubule cells on the carrier associated with one organic anion transport system and exit into the tubular lumen on multiple carriers, one of which is associated with a second system. (+info)
Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin...
Uchiumi T., Hinoshita E., Haga S., Nakamura T., Tanaka T., Toh S., Furukawa M., Kawabe T., Wada M., Kagotani K., Okumura K., Kohno K., Akiyama S., Kuwano M.. The human multidrug resistance protein (MRP) gene encodes a membrane protein involved in the ATP-dependent transport of hydrophobic compounds. We previously isolated a canalicular multispecific organic anion transporter, cMOAT1/MRP2, that belongs to the ATP binding cassette (ABC) superfamily, which is specifically expressed in liver, and cMOAT1/MRP2 is responsible for the defects in hyperbilirubinemia II/Dubin-Johnson syndrome. In this study, we isolated a new cDNA of the ABC superfamily designated cMOAT2/MRP3 that is homologous to human MRP1 and cMOAT1/MRP2: cMOAT2/MRP3 is 56% identical to MRP1 and 45% identical to cMOAT1/MRP2, respectively. Fluorescence in situ hybridization demonstrated the chromosomal locus of this gene on chromosome 17q22. The human cMOAT2 cDNA hybridized to a 6.5-kb mRNA that was mainly expressed in liver and to a ...
Diastrophic Dysplasia: a Devastating Disease
1. Bailey, AJ, et al. Abnormal collagen cross-linking in the cartilage of a Diastrophic Dysplasia patient. British Journal of Rheumatology. 1995 June; 34(6): 512-515 2. Cetta, G, et al. Diastrophic Dysplasia sulfate transporter gene is not involved in Pseudodiastrophic Dysplasia. American Journal of Medical Genetics. 1997 Dec; 73(4): 493-494. 3. Domer, Timothy P. Diastrophic Dysplasia. The Orthopedic Department; The Alfred Dupont Center. http://gait.aidi.udel.edu/res695/homepage/pd_ortho/orthhome.htm. Feb 1, 2000. 4. Forese, LL, et al. Severe mid-cervical kyphosis with cord compression in Larsen`s syndrome and Diastrophic Dysplasia: unrelated syndromes with similar radiologic findings and neurosurgical implications. Pediatric Radiology. 1995; 25(2): 136-139. 5. Greenberg Center for Skeletal Dysplasias. http://ww2.med.jhu.edu/Greenberg.Center/ diastrop.htm. Feb 1, 2000. 6. Hastbacka, J, et al. The Diastrophic Dysplasia gene encodes a novel sulfate transporter: positional cloning by time structure ...
Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with...
TY - JOUR. T1 - Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. AU - Wada, Morimasa. AU - Toh, Satoshi. AU - Taniguchi, Ken. AU - Nakamura, Takanori. AU - Uchiumi, Takeshi. AU - Kohno, Kimitoshi. AU - Yoshida, Ichiro. AU - Kimura, Akihiko. AU - Sakisaka, Shotaro. AU - Adachi, Yukihiko. AU - Kuwano, Michihiko. PY - 1998/2. Y1 - 1998/2. N2 - Members of the ATP-binding cassette (ABC) transporter superfamily are mutated to cause diseases that include cystic fibrosis, hyperinsulinemia, adrenoleukodystrophy, Stargardt disease and multidrug resistance. We recently isolated a novel human member of ABC transporter superfamily as the candidate transporter for the glucuronide and glutathione-conjugated antitumor agents, and found it highly homologous to the rat cmoat gene. Consistent with recent findings of defects in the homologous cmoat gene in two rat models of hyperbilirubinemia ...
Achondrogenesis, type IB - SLC26A2 | Connective Tissue Gene Tests
Achondrogenesis, type IB (ACG1B; MIM 600972) is a lethal condition caused by the diastrophic dysplasia sulfate transporter gene mutations (DTDST/SLC26A2). Affected fetuses are usually in breech position and appear hydropic. The limbs and the trunk are shortened. In contrast to the findings in achondrogenesis, type II (ACG2; MIM 200610), the head is of a normal or near normal size and the fingers and toes are short. The feet and toes are rotated inward, a finding shared with diastrophic dysplasia (DTD; MIM 222600), another disorder caused by DTDST mutations.. Read less ...
Gene Expression Literature Summary - MGI
J:223752 Cai T, Yang L, Cai W, Guo S, Yu P, Li J, Hu X, Yan M, Shao Q, Jin Y, Sun ZS, Luo ZJ, Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene. Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8064-9 ...
Gene Ontology Classifications
Summary is not available for the mouse gene. This summary is for the human ortholog.] The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008 ...
Multispecific Organic Anion Transporter Is Responsible for the Biliary Excretion of the Camptothecin Derivative Irinotecan and...
Irinotecan, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11), is a potent anticancer drug that is increasingly used in chemotherapy. A frequent limiting side effect involves gastrointestinal toxicity (diarrhea), which is thought to be related to the biliary excretion of CPT-11 and its metabolites. Accordingly, the biliary excretion mechanisms for both the lactone and carboxylate forms of CPT-11 and its metabolites, SN-38 and its glucuronide (SN38-Glu), were investigated using Sprague-Dawley (SD) rats and Eisai hyperbilirubinemic rats (EHBR), with the latter being mutant rats with a genetic deficiency of the canalicular multispecific organic anion transporter. After i.v. administration of CPT-11, the biliary excretion clearance, defined as the biliary excretion rate normalized to the hepatic concentration, of both the lactone and carboxylate forms of SN38-Glu was much lower in EHBR. The biliary excretion clearance for the carboxylate form of both CPT-11 and SN-38 was ...
Molecular cloning of higher plant homologues of the high-affinity nitrate transporters of Chlamydomonas reinhardtii and...
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Domain combinations for Phoshotransferase/anion transport protein superfamily
Domain combinations containing the Phoshotransferase/anion transport protein superfamily . Domain architectures illustrate each occurrence of the Phoshotransferase/anion transport protein superfamily.
Anti-NRT1.1 | nitrate transporter 1.1 antibodies
Anti-NRT1.1 | nitrate transporter 1.1 antibodies, AS12 2611, antibody to AtNRT1, Nitrate/chlorate transporter, protein CHLORINA 1, AtNPF6.3, Q05085, AT1G12110
Nitrate transporter structure paves the way for exciting new areas of work Page - Department of Biochemistry, University of...
Nitrate transporter structure paves the way for exciting new areas of work, Representing biochemistry research at Oxford University
High affinity sulfate transporter elisa and antibody
Shop High affinity sulfate transporter ELISA Kit, Recombinant Protein and High affinity sulfate transporter Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Probable sulfate transporter elisa and antibody
Shop Probable sulfate transporter ELISA Kit, Recombinant Protein and Probable sulfate transporter Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
Nitrogen foraging ability of plants relies on mobile shoot-root hormone signal
Nagoya University researchers discovered the molecular mechanisms underlying the shoot-to-root stage of nitrogen-demand signaling in plants. The team found that genes encoding CEPD polypeptides are switched on in the shoots in response to nitrogen starvation in the roots. These polypeptides then descend into the roots, and activate a nitrate transporter gene only if sufficient nitrate is available in the surrounding soil. These findings have implications for maximizing plant nutrient acquisition and improving agricultural productivity.
Supplement House Market dostava za Naselje Kruševac | Naruči na Donesi
Pogledaj meni, fotografije hrane i recenzije Supplement House i naruči na Donesi. Tvoj omiljeni obrok stiže pred vrata za nekoliko minuta!
Choaniki: Sei Naru Protein Densetsu - GameSpot
Find reviews, trailers, release dates, news, screenshots, walkthroughs, and more for Choaniki: Sei Naru Protein Densetsu here on GameSpot.
Posts by Pavol Janega
Pri ileu je v dôsledku rôznych príčin narušená fyziologická motilita čriev. Dôvody jeho vzniku sú rôznorodé, patria k nim mechanické prekážky pasáže obsahu, poruchy prenosu.... ...
Frontiers | Disruption of the ammonium transporter AMT1.1 alters basal defenses generating resistance against Pseudomonas...
Disruption of the high-affinity nitrate transporter NRT2.1 activates the priming defence against Pseudomonas syringae, resulting in enhanced resistance. In this study, it is demonstrated that the high-affinity ammonium transporter AMT1.1 is a negative regulator of Arabidopsis defence responses. The T-DNA knockout mutant amt1.1 displays enhanced resistance against Plectosphaerella cucumerina and reduced susceptibility to P. syringae. The impairment of AMT1.1 induces significant metabolic changes in the absence of challenge, suggesting that amt1.1 retains constitutive defence responses. Interestingly, amt1.1 combats pathogens differently depending on the lifestyle of the pathogen. In addition, N starvation enhances the susceptibility of wild type plants and the mutant amt1.1 to P. syringae whereas it has no effect on P. cucumerina resistance. The metabolic changes of amt1.1 against P. syringae are subtler and are restricted to the phenylpropanoid pathway, which correlates with its reduced susceptibility.
Analysis of Expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, Homologues of the Multidrug Resistance-associated Protein Gene ...
By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1, the gene encoding the multidrug resistance-associated protein, and cMOAT (or MRP2), the canalicular multispecific organic anion transporter gene. We call these new genes MRP3, MRP4, and MRP5. MRP3, like cMOAT, is mainly expressed in the liver. MRP4 is expressed only at very low levels in a few tissues, and MRP5, like MRP1, is expressed in almost every tissue tested. To assess a possible role of these new MRP homologues in multidrug or cisplatin resistance, a large set of resistant cell lines was examined for the (over)expression of MRP1, cMOAT, MRP3, MRP4, and MRP5. We find that even in cells selected for a low level of resistance, several MRP-related genes can be up-regulated simultaneously. However, MRP4 is not overexpressed in any of the cell lines we analyzed; MRP3 and MRP5 are only overexpressed in a few cell lines, and the RNA levels do not seem to correlate with resistance to either ...
Az Diastrophic Dysplasia | Dayton Childrens
During a babys development in the womb, much of the skeleton is made up of a flexible tissue called cartilage that is converted to bone by a process called ossification. Diastrophic dysplasia affects the bodys ability to form cartilage and bones. This results in shorter bones, short stature, joint and hand deformities, and abnormal curving of the spine (lordosis, scoliosis, or kyphosis). Diastrophic dysplasia is also sometimes associated with cleft palate, clubfeet, and ears with a cauliflower-like appearance.. Diastrophic dysplasia is caused by a mutation in a gene responsible for making a protein needed to develop cartilage and convert it to bone. Most of the time, the mutated gene is inherited from ones parents, but in a small number of cases, the mutation happens randomly.. There is no specific treatment for diastrophic dysplasia, but complications like scoliosis and clubfeet are often treated with surgery or the use of special braces or shoes to realign the bones. The goal of treatments ...
The Structure-Function Relationship of Prestin: from an Evolutionary Perspective
Prestin is the motor protein of cochlear outer hair cells. It belongs to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Members of this family serve two fundamentally distinct functions. While most members transport different anion substrates across a variety of epithelia, prestin (SLC26A5) uniquely functions as a voltage-dependent motor protein. This voltage-dependent response of prestin is accompanied by a charge movement, which is reflected in nonlinear capacitance (NLC). . Prestin is assumed to contain a tunnel-like structure which is only accessible from intracellular side, based on a hypothetical working model as a partial anion transporter proposed by Oliver et al. (2001). Intracellular anions such as Cl- act as the external voltage sensor of prestin and trigger the conformational change in the molecule, which in turn alters the surface area of plasma membrane. This study tends to gain insight on the functionally critical structures of prestin using ...
Diastrophic Dysplasia - NORD (National Organization for Rare Disorders)
The symptoms and physical findings associated with diastrophic dysplasia may be extremely variable, differing in range and severity even among affected family members (kindreds). However, in all individuals with the disorder, there is abnormal development of bones and joints of the body (skeletal and joint dysplasia).. During normal development before birth (embryonic and fetal development) as well as development during early childhood, cartilage in many areas of the body is gradually replaced by bone (ossification). In addition, a layer of cartilage (epiphyseal cartilage [growth plate]) separates the shafts (diaphyses) of long bones (e.g., bones of the arms and legs) from their ends (epiphyses), allowing long bones to grow until the cartilage is no longer present. In those affected by diastrophic dysplasia, however, there is delayed growth before and after birth (prenatal and postnatal growth retardation), the development of the ends of the long bones (epiphyses) is irregular, and the ...
Nitrogen Adaptation Strategy of the Wild Teosinte Ancestor of Modern Maize, Zea mays subsp. parviglumis
Examination of wild ancestors can identify which traits have been altered by selection as possible targets for genetic improvement. We investigated the whole plant response to low nitrogen (LN), especially below ground, by the wild ancestor of modern maize (Zea mays L.), Balsas teosinte (Zea mays subsp. parviglumis H. H. Iltis & Doebley). Teosinte responded to LN by reducing the shoot N concentration and increasing the root:shoot biomass ratio. The lengths of individual crown roots and the total lateral root length increased, compensated by reduced crown root number. Low N caused a decrease in total root hair (RH) length and increased expression of high affinity nitrate transporters. To facilitate future mapping studies, these results were compared to a modern inbred (W22) used as the parent in a modern maize × teosinte population and extensively employed in maize domestication studies. The adaptations to LN in teosinte and W22 were surprisingly conserved, but the strategies employed were ...
Solute carrier organic anion transporter family member 1B1 | DrugBank Online
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, ...
Solute carrier organic anion transporter family member 1B3 - DrugBank
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
Solute carrier organic anion transporter family member 1B3 - Molecular Target Profile - BCIQ
International biotechnology industry analysis, data and networking focused on translation, research, development, regulation, commercialization, partnering and funding.
Effect of SLC26 anion transporter disease-causing mutations on the stability of the homologous STAS domain of E. coli DauA ...
The human solute carrier 26 (SLC26) family of anion transporters consists of ten members that are found in various organs in the body including the stomach, intestine, kidney, thyroid and ear where they transport anions including bicarbonate, chloride and sulfate, typically in an exchange mode. Mutations in these genes cause a plethora of diseases such as diastrophic dysplasia affecting sulfate uptake into chondrocytes (SLC26A2), congenital chloride-losing diarrhoea (SLC26A3) affecting chloride secretion in the intestine and Pendreds syndrome (SLC26A4) resulting in hearing loss. To understand how these mutations affect the structures of the SLC26 membrane proteins and their ability to function properly, 12 human disease-causing mutants from SLC26A2, SLC26A3 and SLC26A4 were introduced into the equivalent sites of the sulfate transporter anti-sigma factor antagonist (STAS) domain of a bacterial homologue SLC26 protein DauA (YchM). Biophysical analyses including size-exclusion chromatography, ...
Transcriptome analysis of nitrogen-starvation-responsive genes in rice | BMC Plant Biology | Full Text
The macronutrient nitrogen (N) is an essential component of numerous important compounds, including amino acids, proteins, nucleic acids, chlorophyll, and some plant hormones. This element is a major limiting factor in most agricultural systems. Because the N-utilization efficiency strongly influences crop productivity, a vast amount of N fertilizers is applied to maximize yields. However, it is estimated that more than half of that N is lost from the plant-soil system, with unused N fertilizers severely polluting the environment . Thus, N-uptake efficiency must be increased to improve productivity and reduce pollution.. During periods of N-starvation, various deficiency-responsive genes function to support plant survival by increasing the level of chlorophyll synthesis , altering root architecture , improving N-assimilation , enhancing lignin content , and changing the amounts of sugars and sugar phosphates . Nitrate transporter genes (NRTs) are responsible for the ...
SLCO1B3 Gene - GeneCards | SO1B3 Protein | SO1B3 Antibody
Complete information for SLCO1B3 gene (Protein Coding), Solute Carrier Organic Anion Transporter Family Member 1B3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
SLCO1A2 Gene - GeneCards | SO1A2 Protein | SO1A2 Antibody
Complete information for SLCO1A2 gene (Protein Coding), Solute Carrier Organic Anion Transporter Family Member 1A2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
anti-SLCO1A2 antibody | GeneTex
SLCO1A2 antibody (solute carrier organic anion transporter family, member 1A2) for ELISA, WB. Anti-SLCO1A2 pAb (GTX87607) is tested in Human samples. 100% Ab-Assurance.
Slco1a1 (house mouse) | Gene Target - PubChem
Gene target information for Slco1a1 - solute carrier organic anion transporter family, member 1a1 (house mouse). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.
In this study, we describe transcriptional regulation of the hPDS gene encoding pendrin, a major anion exchanger in the CCD, by UGN, an important modulator of fluid and electrolyte homeostasis. We demonstrate a UGN-induced decrease in both pendrin protein expression (Fig. 2) and pendrin mRNA level (Fig. 3, A and B) in kidneys harvested from mice that were injected with this modulator as well as a UGN-induced reduction in endogenous pendrin mRNA level in renal cells (Fig. 3C). In addition, we demonstrate that UGN decreases hPDS promoter activity in transfected renal cells (Figs. 4 and 5). We show that UGN modulates hPDS promoter activity in large part via a HSE located between nt −1119 and −1115 of the hPDS promoter (Figs. 5 and 6), and we demonstrate that HSF1 likely mediates this UGN-induced modulation (Fig. 7). These findings suggest that pendrin gene expression is subject to HSE/HSF1-mediated transcriptional regulation by UGN.. The renal CCD plays a vital role in acid-base homeostasis and ...
RCSB PDB - 4DGH: Structure of SulP Transporter STAS Domain from Vibrio Cholerae Refined to 1.9 Angstrom Resolution
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
RCSB PDB - 4XS5: Crystal structure of Sulfate transporter/antisigma-factor antagonist STAS from Dyadobacter fermentans DSM 18053
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Antivirotika | Medicína, nemoci, studium na 1. LF UK
Antivirotika jsou extrémně pestrou skupinou léčiv, které nejrůznějšími mechanizmy působí proti virovým částicím. Některé narušují replikaci virové DNA, jiné blokují tvorbu virových částic v postižené buňce, další narušují průnik virů do buňky atp ...
Answers for Assignment 9 (Fall 2008) - STAS2126 Assignment#9(Fall 2008 Submit to Dropbox not by emailUse your first and last...
View Notes - Answers for Assignment_9 (Fall 2008) from BBA STAS2126 at Laurentian. STAS2126 Assignment#9 (Fall 2008) Submit to Dropbox not by emailUse your first and last name as the file name Do NOT
Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney<...
TY - JOUR. T1 - Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. AU - Masuda, Satohiro. AU - Ibaramoto, Koji. AU - Takeuchi, Ayako. AU - Saito, Hideyuki. AU - Hashimoto, Yukiya. AU - Inui, Ken Ichi. PY - 1999/4/19. Y1 - 1999/4/19. N2 - We have isolated a cDNA coding a new organic anion transporter, OAT-K2, expressed specifically in rat kidney. The OAT-K2 cDNA had an open reading frame encoding a 498-amino acid protein (calculated molecular mass of 55 kDa) that shows 91% identity with the rat kidney-specific organic anion transporter, OAT, K1. Reverse transcription-coupled polymerase chain reaction analyses revealed that the OAT-K2 mRNA was expressed predominantly in the proximal convoluted tubules, proximal straight tubules and cortical collecting ducts. When expressed in Xenopus oocytes, OAT-K2 stimulated the uptake of hydrophobic organic anions, such as taurocholate, methotrexate, folate, and prostaglandin E2, although its homolog ...
Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus...
1) We have prepared murine monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein (band 3). (2) All of these antibodies react with regions of the protein located at the cytoplasmic surface of the red cell. (3) One of the antibodies reacts with an epitope present on a cytoplasmic loop of the protein located between the C-terminus and a point 168 amino acids from the C-terminus. The other antibodies recognize different epitopes on the C-terminal tail of the protein and the sequences likely to be involved in these epitopes are defined. (4) Our results show that the C-terminus of the red-cell anion transport protein is located on the cytoplasmic side of the red-cell membrane. (5) None of the antibodies inhibited sulphate exchange transport when introduced into resealed red-cell membranes; however, the bivalent form of one of the antibodies reduced the inhibitory potency of 4-acetamido-4-isothiocyanatostilbene disulphonate on sulphate exchange transport in ...
Effects of Organic Anions and Bile Acid Conjugates on Biliary Excretion of Pravastatin in the Rat - Semantic Scholar
Purpose. Biliary organic anion excretion is mediated by an ATP-dependent primary active transporter, a so-called canalicular multispecific organic anion transporter (cMOAT). As there appear to be many canalicular organic anion transports, we examined the effects of various organic anions and bile acid conjugates on the biliary excretion of pravastatin in rats. Methods. [l4C]pravastatin was intravenously injected into rats with bile drainage in the presence and absence of the continuous infusion of organic anions and bile acids, and radioactivity of its biliary excretion was studied. Results. Biliary excretion of [14C]pravastatin was markedly inhibited by sulfobromophthalein-glutathione, taurolithocholate-3-sulfate, ursodeoxycholate-3,7-sulfate, and ursodeoxycholate-3-O-glucuronide. In contrast, dibromosulfophthalein only slightly inhibited biliary pravastatin excretion, and cefpiramide did not affect biliary pravastatin excretion. Conclusions. These findings further support the multiplicity of
Identification of nitrate transporter genes in Chlamydomonas reinhardtii
The Chlamydomonas reinhardtii nar-2, nar-3, and nar-4 genes, which are within a nitrate-regulated gene cluster containing the nitrate reductase structural gene nit-1, have been related to nitrate transport. Mutant strains defective in nitrate transport and having an active nitrate reductase have bee …
Two novel mutations including a large deletion of the SLC4A11 gene causing autosomal recessive hereditary endothelial dystrophy...
Congenital hereditary endothelial dystrophy (CHED) is an inherited disorder of the corneal endothelium characterised by bilateral non-inflammatory corneal clouding ranging from a diffuse haze to a ground-glass appearance. CHED can be inherited in an autosomal dominant (CHED1) or recessive (CHED2) manner. CHED2 usually presents at birth or early infancy. Bilateral corneal clouding can lead to visual impairment often accompanied by nystagmus in CHED2 patients requiring corneal transplantation.1 Mutations in the solute carrier family 4 member 11 (SLC4A11) gene have been identified in most patients with CHED2. With PCR sequencing of the entire coding and putative promoter regions of SLC4A11, there were, however, some clinically confirmed CHED2 patients with undetected SLC4A11 mutations.2 ...
Irinotecan is a relatively new anticancer agent of interest for both its clinical activity and its complex clinical pharmacology. It is a prodrug, requiring activation by carboxylesterases to SN-38, an inhibitor of topoisomerase I. Recent studies suggest that human carboxylesterase-2 is the primary carboxylesterase involved in the hydrolysis at pharmacological concentrations (1) . Irinotecan is also oxidized by CYP3A43 to the inactive metabolite 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino]carbonyloxycamptothecin as well as to 7-ethyl-10-[4-(piperidino)-1-amino]carbonyloxycamptothecin, which can undergo hydrolysis to SN-38 (2, 3, 4) . SN-38 undergoes glucuronidation by UGT1A1 (5) and is possibly oxidized by CYP3A4 as well (6) . Mass balance studies have demonstrated that 64% of the total dose is excreted in the feces, confirming the important role of biliary excretion (7) . Studies suggest that canalicular multispecific organic anion transporter is the major transporter of irinotecan and ...
OsNRT1.1a is a low-affinity nitrate (NO3 ) transporter gene. In this study, another mRNA splicing product, OsNRT1.1b, putatively encoding a protein with six transmembrane domains, was identified based on the rice genomic database and bioinformatics analysis. OsNRT1.1a/OsNRT1.1b expression in Xenopus oocytes showed OsNRT1.1a-expressing oocytes accumulated 15N levels to about half as compared to OsNRT1.1b-expressing oocytes. The electrophysiological recording of OsNRT1.1b-expressing oocytes treated with 0.25mM NO3 confirmed 15N accumulation data. More functional assays were performed to examine the function of OsNRT1.1b in rice. The expression of both OsNRT1.1a and OsNRT1.1b was abundant in roots and downregulated by nitrogen (N) deficiency. The shoot biomass of transgenic rice plants with OsNRT1.1a or OsNRT1.1b overexpression increased under various N supplies under hydroponic conditions compared to wild-type (WT). The OsNRT1.1a overexpression lines showed increased plant N accumulation compared ...
DMOZ - Health: Conditions and Diseases: Musculoskeletal Disorders: Congenital Anomalies: Dwarfism: Diastrophic Dysplasia
Diastrophic dysplasia (DTD) is a chondrodysplasia causing severe growth retardation, and structural and functional abnormalities of joints. Growth retardation and joint abnormalities are already present in utero, and mean height at birth is 32.5 cm. Extremities are short while the trunk is of normal size, upper arms show ulnar deviation with stiff fingers and a hitchhiker thumb. Hips are stiff and most patients have club foot. A cleft palate is frequent. Growth remains slow, the median adult height for males is 135 cm and 129 cm for females. Changes in the joints often progress with age and corrective surgery becomes necessary.
The extracellular loop of pendrin and prestin modulates their voltage-sensing property<...
TY - JOUR. T1 - The extracellular loop of pendrin and prestin modulates their voltage-sensing property. AU - Kuwabara, Makoto F.. AU - Wasano, Koichiro. AU - Takahashi, Satoe. AU - Bodner, Justin. AU - Komori, Tomotaka. AU - Uemura, Sotaro. AU - Zheng, Jing. AU - Shima, Tomohiro. AU - Homma, Kazuaki. PY - 2018/1/1. Y1 - 2018/1/1. N2 - Pendrin and prestin belong to the solute carrier 26 (SLC26) family of anion transporters. Prestin is unique among the SLC26 family members in that it displays voltage-driven motor activity (electromotility) and concurrent gating currents that manifest as nonlinear cell membrane electrical capacitance (nonlinear capacitance (NLC)). Although the anion transport mechanism of the SLC26 proteins has begun to be elucidated, the molecular mechanism of electromotility, which is thought to have evolved from an ancestral ion transport mechanism, still remains largely elusive. Here, we demonstrate that pendrin also exhibits large NLC and that charged residues present in one ...
A to Z: Diastrophic Dysplasia (for Parents) - CareSource (naked/frame)
Diastrophic dysplasia is a rare genetic disorder that interferes with bone development and causes abnormal bone growth and dwarfism (short stature).
Members of the LBD Family of Transcription Factors Repress Anthocyanin Synthesis and Affect Additional Nitrogen Responses in...
Author: Rubin, G. et al.; Genre: Journal Article; Published in Print: 2009; Open Access; Keywords: affinity nitrate transporter|br/|sucrose-specific induction|br/|knox gene-expression|br/|lob domain protein|br/|p-i starvation|br/|enzyme-activities|br/|phenylpropanoid biosynthesis|br/|flavonoid biosynthesis|br/|environmental nitrate|br/|secondary metabolism; Title: Members of the LBD Family of Transcription Factors Repress Anthocyanin Synthesis and Affect Additional Nitrogen Responses in Arabidopsis
OpenEmory | Search Results
Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption. We asked if pendrin is expressed in vascular tissue and if the lower blood pressure observed in pendrin null mice is accompanied by reduced vascular reactivity. Thus, the contractile responses to KCl and phenylephrine (PE) were examined in isometrically mounted thoracic aortas from wild-type and pendrin null mice. Although pendrin expression was not detected in the aorta, pendrin gene ablation changed contractile protein abundance and increased the maximal contractile response to PE when normalized to cross sectional area (CSA). However, the contractile sensitivity to this agent was unchanged. The increase in contractile force/cross sectional area observed in pendrin null mice was due to reduced cross sectional area of the aorta and not from increased contractile force per vessel. The pendrin-dependent ...
SLCO1A2 - wikidoc
Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene. This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms. ...
NaBC1 is a ubiquitous electrogenic Na<sup>+</sup>-coupled borate transporter essential for cellular boron homeostasis and cell...
TY - JOUR. T1 - NaBC1 is a ubiquitous electrogenic Na+-coupled borate transporter essential for cellular boron homeostasis and cell growth and proliferation. AU - Park, Meeyoung. AU - Li, Qin. AU - Shcheynikov, Nikolay. AU - Zeng, Weizong. AU - Muallem, Shmuel. PY - 2004/11/5. Y1 - 2004/11/5. N2 - Boron is a vital micronutrient in plants and may be essential for animal growth and development. Whereas the role of boron in the life cycle of plants is well documented, nothing is known about boron homeostasis and function in animal cells. NaBC1, the mammalian homolog of AtBor1, is a borate transporter. In the absence of borate, NaBC1 conducts Na+ and OH- (H+), while in the presence of borate, NaBC1 functions as an electrogenic, voltage-regulated, Na+-coupled B(OH)4 - transporter. At low concentrations, borate activated the MAPK pathway to stimulate cell growth and proliferation, and at high concentrations, it was toxic. Accordingly, overexpression of NaBC1 shifted both effects of borate to the left, ...
Biliary Excretion of Pravastatin in Rats: Contribution of the excretion pathway mediated by canalicular multispecific organic...
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OGC Community approves new OGC API standard: OGC API - Features - Part 2: Coordinate Reference Systems by Reference | OGC
The Open Geospatial Consortium (OGC) is excited to announce the adoption of the latest of its OGC API family of standards: OGC API - Features - Part 2: Coordinate Reference Systems by Reference.. OGC APIs usher in a new age for discovering and accessing location information on the web, enabling a much simpler way to share and access location information that is consistent with the architecture of the Web. The OGC API family of standards defines modular API building blocks to spatially enable Web APIs in a consistent way. Through the OGC APIs, the OGC community is standardizing how location information can be integrated: by any developer, with any other type of information, and into any type of application.. The new OGC APIs make use of the OpenAPI Specification (OAS) - a broadly adopted industry standard for describing modern APIs. APIs that implement OAS provide an interface that enables humans and computers to easily discover and understand the capabilities of a service without having to refer ...
Rapid electrogenic sulfate-chloride exchange mediated by chemically modified band 3 in human erythrocytes. | Journal of General...
One of the modes of action of the red blood cell anion transport protein is the electrically silent net exchange of 1 Cl- for 1 SO4= and 1 H+. Net SO4(=)-Cl- ex
Epithelial Anion Transport in Health and Disease
Find all books from Novartis Foundation - Epithelial Anion Transport in Health and Disease. At find-more-books.com you can find used, antique and new books, COMPARE results and immediately PURCHASE your selection at the best price. 9780470029565
STAS domain (IPR002645) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
M sta, obce, osady, samoty a objekty zanikl nebo ste n zanikl (dobov pohlednice, historie, vojensk mapy, m stopis)
V deln kolon da byla postavena v dob od 1. jna 1878 do 27. dubna 1879 na m st star d ev n kolon dy podle projektu v de sk ch architekt Ferdinanda Fellnera a Hermanna Gottlieba Helmera. Proto e litinov d ly byly spojov ny ocelov mi prvky, do lo k naru en stability a na ja e roku 1939 bylo p ikro eno k jej demolici. V roce 1946 byla postavena dal konstrukce od architekta Ladislava Koz ka, kter vydr ela tvrt stolet , ve fotogalerii je uvedena jako prozat mn kolon da. V roce 1975 byla otev ena nov V deln kolon da, d lo architekta J. Otruby. ...
GynoDren - Joalis - oficiálna stránka distribútora detoxikačných produktov Joalis v SR
Preparát GynoDren priaznivo vplýva na gynekologické ústrojenstvo. Toxicky zaťažené gynekologické ústrojenstvo môže viesť až k narušeniu funkcie vaječníkov, vajcovodov, maternice i pošvy; dôsledkom môžu byť poruchy plodnosti, zápaly či poruchy sexuálneho života. Zloženie: 20% lieh, rastliny: vŕbovk
Bilietai kišenėje arba... pratęstas malonumas
Tenka pripažinti, kad bilietai kišenėje - pasenęs posakis. Neatsimenu, kada paskutinį kartą bilietą iš tiesų turėjau kišenėje. Dažniausiai ta kišenė - paprastas elektroninis dokumentas kažkurioje kompiuterio byloje. Vis dėlto, vos įsigyji bilietus, kad ir elektroninius, širdį užlieja malonus laukimas.
anion - Wikislovar, prosti slovar
Besedilo je na razpolago pod licenco Creative Commons Priznanje avtorstva-Deljenje pod enakimi pogoji 3.0; veljajo lahko tudi dodatni pogoji. Podrobnosti so razložene na strani Pogoji uporabe ...
SLC39A11兔多克隆抗体(ab83950)可与小鼠, 大鼠, 人样本反应并经WB, ELISA, IHC实验严格验证。所有产品均提供质保服务，中国75%以上现货。
Solute carrier family 10 member 4
... a putative organic anion transport protein". World Journal of Gastroenterology. 12 (42): 6797-805. doi:10.3748/wjg.v12.i42.6797 ... Solute carrier family 10 member 4 is a protein that in humans is encoded by the SLC10A4 gene. In mice, it appears to promote ...
Cells also contain anion antiporters such as the Band 3 (or AE1) anion transport protein. This cotransporter is an important ... to provide the power needed for transport. This type of transport is known as secondary active transport and is powered by the ... For instance the wheat HKT1 transporter shows two modes of transport by the same protein. Cotransporters can be classified as ... ISBN 978-1-4292-3413-9. Chrispeels, Maarten J.; Nigel M. Crawford; Julian I. Schroeder (April 1999). "Proteins for Transport of ...
"Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs". Proceedings ... Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene. The protein encoded by this ... ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct ... "Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5". ...
"Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced ... Conjugated bilirubin is excreted into canalicular bile by way of the canalicular multispecific organic anion transport (C-MOAT ... These conditions are associated with either defective intracellular protein binding (for the second time) or disturbed ... Erlinger, Serge; Arias, Irwin M.; Dhumeaux, Daniel (2014). "Inherited Disorders of Bilirubin Transport and Conjugation: New ...
1988 Award of the Polish Academy of Sciences for participation in studies on Band 3 anion transport protein. 1989 Parnas Award ... carcinoembryonic antigen forms dimers in solution and was the first to demonstrate that human Band 3 anion transport protein is ... She identified that these antigens were carried by the glycosylated protein of the erythrocyte membrane called glycophorins. At ... Lisowska, Elwira (2002-10-11). "The role of glycosylation in protein antigenic properties". Cellular and Molecular Life ...
Organic cation transport proteins Organic anion-transporting polypeptide Solute carrier family Osmoregulation Organic anion ... The generalized transport reaction catalyzed by OSTα/OSTβ is: organic anion (out) ⇌ organic anion (in) Each transport system ... The two proteins are highly expressed in many human tissues. The β-subunit is not required to target the α-subunit to the ... Transport of estrone sulfate by the two subunit Ost transporter of Raja erinacea (TC# 2.A.82.1.1) is Na+-independent, ATP- ...
As the blood pH increases, blood transport proteins, such as albumin, become more ionized into anions. This causes the free ...
"The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695-9 ... organic anion transport. • thyroid hormone transport. • sodium-independent organic anion transport. • transmembrane transport. ... Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene. ... "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion ...
Rosen BP, Weigel U, Monticello RA, Edwards BP (1991). "Molecular analysis of an anion pump: purification of the ArsC protein". ... Rosen BP, Weigel U, Monticello RA, Edwards BP (1991). "Molecular analysis of an anion pump: purification of the ArsC protein". ... In enzymology, an arsenite-transporting ATPase (EC 220.127.116.11) is an enzyme that catalyzes the chemical reaction ATP + H2O + ...
... and organic anion transporting polypeptide 1B3 (OATP1B3), respectively. Both proteins are found in liver cells; they transport ... nonfunctional OATP1B1 and OATP1B3 proteins or an absence of these proteins. Without the function of either transport protein, ... The SLCO1B1 and SLCO1B3 genes provide instructions for making similar proteins, called organic anion transporting polypeptide ... Rotor syndrome is caused by mutations in two proteins responsible for transporting bilirubin and other compounds from the blood ...
"The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C ... Na(+)/H(+) exchange regulatory cofactor NHE-RF3 is a protein that in humans is encoded by the PDZK1 gene. PDZK1 has been shown ... Kocher O, Comella N, Gilchrist A, Pal R, Tognazzi K, Brown LF, Knoll JH (1999). "PDZK1, a novel PDZ domain-containing protein ... White KE, Biber J, Murer H, Econs MJ (1999). "A PDZ domain-containing protein with homology to Diphor-1 maps to human ...
"The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C ... The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the ... Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in ... This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms ...
Red blood cell
The red blood cell membrane proteins organized according to their function: Transport Band 3 - Anion transporter, also an ... Protein 4.1R-based macromolecular complex - proteins interacting with Protein 4.1R. Protein 4.1R - weak expression of Gerbich ... facilitated by the band 3 anion transport protein colocated in the RBC membrane. The bicarbonate ion does not diffuse back out ... These membrane proteins can perform a wide diversity of functions, such as transporting ions and molecules across the red cell ...
... camera Anion Exchanger 1, a transport protein A size designation for Constantinian bronze coins AE1/AE3 antibody cocktail used ...
... transport protein Ape Escape 2 A size designation for Constantinian bronze coins Applied Energistics 2, a mod for the video ... AE2 may refer to: HMAS AE2, E-class submarine of the Royal Australian Navy Aero Ae 02, a design of Czechoslovakian plane Anion ...
"Borate as a synergistic anion for Marinobacter algicola ferric binding protein, FbpA: a role for boron in iron transport in ...
... they release proteins which facilitate active transport of lightweight anions between leaf and fungus even before germination. ... from which 437 encoded candidate secretor proteins and 165 for non-secreted candidate secretor proteins. These were shown to be ... The exact mechanism of action is unknown, but one known effect is that ferroglobulin, a protein in whey, produces oxygen ... selective pressure acting on genes that code for candidate secretor proteins and non-secreted candidate secretor proteins, ...
Anion exchanger family
Anion exchanger proteins exchange HCO3 − for Cl− in a reversible, electroneutral manner. Na+/HCO3 − co-transport proteins ... The same transport site within the AE1 spanning domain is involved in both anion exchange and cation transport. AE1 in human ... In these proteins it covers almost the entire length of the sequence. The Band 3 anion exchange proteins that exchange ... A conserved domain is found at the C terminus of many bicarbonate transport proteins. It is also found in some plant proteins ...
Organic cation transport protein
This family of proteins can also transport zwitterions and anions, though it is a different subfamily of solute carrier ... An organic cation transport protein mediates the transport of organic cations across the cell membrane. These proteins are ...
Mitochondrial membrane transport protein
Sam37 accommodates the release of the folded β-barrel proteins from the SAM complex. VDAC (voltage-dependent anion ion channel ... Mitochondrial membrane transport proteins, also known as mitochondrial carrier proteins, are proteins which exist in the ... Phosphate transport proteins are responsible for transport of phosphate across the inner membrane so it can be used in the ... The outer membrane consists of two types of integral proteins, including proteins with transmembrane β-barrel and proteins with ...
Anion exchange protein 3
... is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally ... Morgans CW, Kopito RR (1993). "Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin". J. Cell Sci. ... "Entrez Gene: SLC4A3 solute carrier family 4, anion exchanger, member 3". Casey JR, Sly WS, Shah GN, Alvarez BV (November 2009 ... 2001). "Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization". Biochim. Biophys. Acta ...
Anion exchange protein 2
... (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. AE2 is ... Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human ... "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)". Gawenis ... Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in ...
Southeast Asian ovalocytosis
... increased tyrosine phosphorylation of the band 3 protein, reduced sulfate anion transport through the cell membrane, and more ... Rather, the defect lies in a protein known as the band 3 protein, which lies in the cell membrane itself. The band 3 protein ... The band 3 proteins aggregate on the cell membrane at the site of entry, forming a circular orifice that the parasite squeezes ... These band 3 proteins act as receptors for the parasite. Normally a process much like endocytosis occurs, and the parasite is ...
Organic anion transporter 1
2004). "Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier ... OAT1 functions as organic anion exchanger. When the uptake of one molecule of an organic anion is transported into a cell by an ... It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in ... and OATP4C1 transport small organic anions from the plasma into the S2 cells. MDR1, MRP2, MRP4 and URAT1 then transports these ...
Organo anion transporter family
... organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of ... The generalized transport reactions catalyzed by members of the OAT family are: Anion (in) → Anion (out) Anion1 (in) + Anion2 ( ... Proteins of the OAT family catalyze the Na+-independent facilitated transport of fairly large amphipathic organic anions (and ... transporting anions, as well as neutral and even cationic compounds. They also transport an extremely diverse range of drug ...
Band 3 anion transport protein
... is a phylogenetically-preserved transport protein responsible for mediating the exchange of ... Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), ... Diego blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH Band+3+Protein at the US National ... The erythrocyte and kidney forms are different isoforms of the same protein. The erythrocyte isoform of AE1, known as eAE1, is ...
Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleoside analogs. Proc Natl ... an organic anion transporter able to transport anti-cancer drugs. Proc Natl Acad Sci U S A. 1999;96:6914-9. Wijnholds J, Mol ... Hydrogen transport and transport metabolites. In: Karlsson P, editor. Springer Verlag. Funktionelle und morphologische ... Identification of the Volume-Regulation Anion Channel, as a contributor to uptake of Pt-based anti-cancer drugs in cells (49). ...
For medications that interact due to inhibition of OATP (organic anion-transporting polypeptides), a relative short period of ... Bioactive compounds in grapefruit juice may also interfere with MDR1 (multidrug resistance protein 1) and OATP (organic anion ... Andrade, Chittaranjan (24 November 2014). "Fruit Juice, Organic Anion Transporting Polypeptides, and Drug Interactions in ... possible role of organic anion transporting polypeptides". Clinical Pharmacology and Therapeutics. 77 (3): 170-7. doi:10.1016/j ...
... whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting ... Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene. It is an anion-exchanger ... 2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion ... Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter ...
... protein import-related anion channel (PIRAC). Most of the Tic110 protein is probably in the intermembrane space. Transport ... anions (out) ⇌ anions (in) (2) proteins (out) → proteins (in) Lübeck, J.; Soll, J.; Akita, M.; Nielsen, E.; Keegstra, K. (1996- ... This family consists of the inner membrane protein import apparatus, and appears to be a protein import-related anion-selective ... The Chloroplast Envelope Anion Channel-forming Tic110 (Tic110) Family (TC#1.A.18) consists of proteins of the inner chloroplast ...
Diverse bile acids are synthesized in the liver. Bile acids are conjugated with taurine or glycine residues to give anions ... About 95% of bile acids are reabsorbed by active transport in the ileum and recycled back to the liver for further secretion ... Among these protein targets, the enzyme N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) generates bioactive ... Bile acids bind to some other proteins in addition to their hormone receptors (FXR and TGR5) and their transporters. ...
transmembrane transport. • calcium ion transport. • regulation of ventricular cardiac muscle cell action potential. • embryonic ... Calcium channel, voltage-dependent, L type, alpha 1C subunit (also known as Cav1.2) is a protein that in humans is encoded by ... regulation of ion transmembrane transport. • ion transport. • calcium-mediated signaling using extracellular calcium source. • ... Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [§ 1] ...
... identified a protein that later became known as superoxide dismutase as an indophenol oxidase by protein analysis of starch ... The superoxide anion radical (O2−) spontaneously dismutes to O2 and hydrogen peroxide (H2O2) quite rapidly (~105 M−1s−1 at pH 7 ... when it absorbs an excited electron released from compounds of the electron transport chain. Superoxide is known to denature ... SOD1 is an extremely stable protein. In the holo form (both copper and zinc bound) the melting point is , 90 °C. In the apo ...
Distribution: When injected, pentamidine binds to tissues and proteins in the plasma. It accumulates in the kidney, liver, ... Nitroxyl anion (NO−; oxonitrate(1-), hyponitrite anion). *Nitric oxide (NO⋅; nitrogen monoxide) ... Pentamidine is brought into the mitochondria through carrier proteins, and the absence of these carriers prevents the drug from ... phospholipid and protein synthesis. Pentamidine binds to adenine-thymine-rich regions of the Trypanosoma parasite DNA, ...
Glossary of biology
active transport. Transport of a substance (such as a protein or drug) across a cell membrane against a concentration gradient ... and the nonmetal accepts those electrons to become a negatively charged anion.. isomer. A molecule with the same chemical ... A form of active transport in which a cell transports molecules such as proteins into the cell's interior by engulfing them in ... A form of active transport and bulk transport in which a cell transports molecules out of the cell by expelling them through an ...
"Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse ... electron transport chain. • cellular hyperosmotic salinity response. • retinoid metabolic process. • metanephric collecting ... 2acq: AN ANION BINDING SITE IN HUMAN ALDOSE REDUCTASE: MECHANISTIC IMPLICATIONS FOR THE BINDING OF CITRATE, CACODYLATE, AND ... Protein. AKR1B1 consists of 316 amino acid residues and weighs 35853Da. It does not possess the traditional dinucleotide ...
"Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels". J. ... Tenovuo J (January 2002). "Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in ... "The Lactoperoxidase System Links Anion Transport To Host Defense in Cystic Fibrosis". FEBS Lett. 581 (2): 271-8. doi:10.1016/j. ... Hypothiocyanite is the anion [OSCN]− and the conjugate base of hypothiocyanous acid (HOSCN). It is an organic compound part of ...
... proteins and their genes must be co-located for redox regulation according to the CoRR hypothesis for the function of DNA ... Once formed, these anion free radicals reduce molecular oxygen to superoxide, and regenerate the unchanged parent compound. The ...
regulation of protein stability. • transferrin transport. • iron ion homeostasis. • platelet degranulation. • ion transport. • ... For the iron ion to bind, an anion is required, preferably carbonate (CO2−. 3). ... Transport mechanism. When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a ... "Transferrin is an insulin-like growth factor-binding protein-3 binding protein". The Journal of Clinical Endocrinology and ...
It is used to store oxygen rather than transport it.. Hemocyanin. The second most common oxygen-transporting protein found in ... NO is not released in the cytoplasm of red blood cells but transported out of them by an anion exchanger called AE1. ... Each subunit is composed of a protein chain tightly associated with a non-protein prosthetic heme group. Each protein chain ... Nitric oxide can also be transported by hemoglobin; it is bound to specific thiol groups in the globin protein to form an S- ...
Red blood cell
... membrane major proteins. Transport *Band 3 - Anion transporter, also an important structural component of the ... Protein 4.1R-based macromolecular complex - proteins interacting with Protein 4.1R. *Protein 4.1R - weak expression of Gerbich ... These membrane proteins can perform a wide diversity of functions, such as transporting ions and molecules across the red cell ... PIP2 enhances the binding of protein band 4.1R to glycophorin C but decreases its interaction with protein band 3, and thereby ...
The Lactoperoxidase System Links Anion Transport To Host Defense in Cystic Fibrosis. . In: FEBS Lett.. . 581, Nr. 2, Januar ... Bändermodell der Lactoperoxidase der Hausziege (Capra hircus). Das Protein ist in Regenbogenfarben dargestellt (N-Terminus = ... Evaluation of the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lysozyme ...
Gel electrophoresis of proteins
The separated proteins are continuously eluted into a physiological eluent and transported to a fraction collector. In a few ... As voltage is applied, the anions (and negatively charged sample molecules) migrate toward the positive electrode (anode) in ... Discontinuous native protein gel electrophoresis Protein purification facility Educational resource for protein electrophoresis ... Protein electrophoresis is a method for analysing the proteins in a fluid or an extract. The electrophoresis may be performed ...
The signaling molecules bind to proteins, which alters the protein. A message is sent into the cell and a specific cellular ... passive transport or active transport.[dubious - discuss] The rate of passage depends on the pressure, concentration, and ... anion exchange membrane (AEM) alkali anion exchange membrane (AAEM) and proton exchange membrane (PEM). ... A cell membrane consists of proteins and phospholipids. Signaling molecules send chemical messages to the proteins in the ...
Cl transportujuća ATPaza - Википедија, слободна енциклопедија
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley- ... of reconstitution of the Cl--translocating ATPase isolated from Acetabularia acetabulum into liposomes and several anion pump ... Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins ( ... Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.. ...
Mitochondrial thiamine pyrophosphate carrier
Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A). By group ... mitochondrial transport. • thiamine pyrophosphate transport. • thiamine transmembrane transport. • transport. Sources:Amigo / ... deoxynucleotide transport. • transmembrane transport. • thiamine-containing compound metabolic process. • ... This membrane protein-related article is a stub. You can help Wikipedia by expanding it.. *v ...
... the superoxide anion is produced as a by-product of several steps in the electron transport chain. Particularly important ... The thioredoxin system contains the 12-kDa protein thioredoxin and its companion thioredoxin reductase. Proteins related ... while damage to proteins causes enzyme inhibition, denaturation and protein degradation. ... Jönsson TJ, Lowther WT (2007). The peroxiredoxin repair proteins. Sub-Cellular Biochemistry. Subcellular Biochemistry. 44. pp. ...
CooA is a carbon monoxide sensor protein. The scope of its biological role is still unknown; it may be part of a signaling ... Due to its long lifetime in the mid-troposphere, carbon monoxide is also used as tracer of transport for pollutant plumes. ... It is the simplest oxocarbon and is isoelectronic with the cyanide anion, the nitrosonium cation and molecular nitrogen. In ...
Transport properties Irisations Maths Applications Fun Surfactants. Micelles, HLB. Surface rheology, adsorption. Langmuir ... Milder detergents such as octyl thioglucoside, octyl glucoside or dodecyl maltoside are used to solubilize membrane proteins ... The most common biological zwitterionic surfactants have a phosphate anion with an amine or ammonium, such as the phospholipids ... This process maintains a matrix of proteins that preserves the structure of the organ and often the microvascular network. The ...
... forms the monocapped trigonal prismatic anion [Th(CH3)7]3−, heptamethylthorate, which forms the salt [Li(tmeda)]3[ThMe7 ... "Evaluation of nuclear criticality safety data and limits for actinides in transport" (PDF). Institut de radioprotection et de ... "Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and ... Many other inorganic thorium compounds with polyatomic anions are known, such as the perchlorates, sulfates, sulfites, nitrates ...
Magnesium in biology
... multiple simultaneous interactions with the transport protein at this level might significantly retard the ion in the transport ... stabilising anions or reactive intermediates, also including binding to ATP and activating the molecule to nucleophilic attack ... ProteinsEdit. The Mg2+ ion tends to bind only weakly to proteins (Ka ≤ 105) and this can be exploited by the cell to switch ... To date, only the ZntA protein of Paramecium has been shown to be a Mg2+ channel. The mechanisms of Mg2+ transport by the ...
ATP-binding cassette transporter
... both required for transport function, or intragenicly to give 8 or 10 TMS proteins. The 10 TMS proteins appear to have two ... A few ABCC family members, also known as MRP, have also been demonstrated to confer MDR to organic anion compounds. The most- ... transport protein which was originally called P-glycoprotein (P-gp), but it is also referred to as multidrug resistance protein ... When the ABC transport proteins are overexpressed in cancer cells, they can export anticancer drugs and render tumors resistant ...
... nitrate anions are often consumed rapidly by plants to form proteins, leaving an excess of cations in solution. This cation ... Too much and the plant will be unable to access oxygen; too little and the plant will lose the ability to transport nutrients, ... is a method wherein plants are grown in an inert porous medium that transports water and fertilizer to the roots by capillary ...
Water spontaneously ionizes into hydroxide anions and hydronium cations. The salt also dissociates into its constituent anions ... However, proteases do not catalyse the hydrolysis of all kinds of proteins. Their action is stereo-selective: Only proteins ... and the active transport of ions and molecules across cell membranes. The energy derived from the oxidation of nutrients is not ... Therefore, proteins that do not fit into the crevice will not undergo hydrolysis. This specificity preserves the integrity of ...
Na+/K+ transporting: ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP1B4 Ca++ transporting: ATP2A1, ATP2A2, ATP2A3, ... ATP13A5 ATP synthase ATP synthase alpha/beta subunits AAA proteins P-ATPase Geider K, Hoffmann-Berling H (1981). "Proteins ... Riley MV, Peters MI (June 1981). "The localization of the anion-sensitive ATPase activity in corneal endothelium". Biochimica ... ATP2B1, ATP2B2, ATP2B3, ATP2B4, ATP2C1, ATP2C2 Mg++ transporting: ATP3 H+/K+ exchanging: ATP4A H+ transporting, mitochondrial: ...
and hydroxide anions OH−. . Sodium hydroxide is a highly caustic base and alkali that decomposes proteins at ordinary ambient ... In 1986, an aluminium road tanker in the UK was mistakenly used to transport 25% sodium hydroxide solution, causing ... It also hydrolyzes the proteins such as those found in hair which may block water pipes. These reactions are sped by the heat ... It can dissolve grease, oils, fats and protein-based deposits. It is also used for cleaning waste discharge pipes under sinks ...
CFTR - ویکیپدیا، دانشنامهٔ آزاد
protein deubiquitination. • membrane organization. • ATP hydrolysis coupled anion transmembrane transport. • chloride ... cholesterol transport. • ion transport. • vesicle docking involved in exocytosis. • transmembrane transport. • sperm ... protein complex. • cell surface. • lysosomal membrane. • early endosome. • Golgi-associated vesicle membrane. • endoplasmic ... transepithelial water transport. • multicellular organismal water homeostasis. • cellular response to forskolin. • bicarbonate ...
protein binding. • actin binding. • calcium channel activity. • cation channel activity. • protein homodimerization activity. • ... manganese ion transport. • cellular response to hypoxia. • calcium ion transport. • cellular response to hydrogen peroxide. • ... cation transport. • ion transport. • single fertilization. • platelet activation. • positive regulation of ion transmembrane ... This membrane protein-related article is a stub. You can help Wikipedia by expanding it.. *v ...
Chromate anions (CrO2−. 4) and dichromate (Cr2O72−) anions are the principal ions at this oxidation state. They exist at an ... "Protein Data Bank (1LM2). doi:10.2210/pdb1LM2/pdb. Retrieved 8 November 2018.. ... The chromium(III) is excreted from the body, whereas the chromate ion is transferred into the cell by a transport mechanism, by ... A tetrahedral coordination of Chromium(III) has been reported for the Cr-centered Keggin anion [α-CrW12O40]5-. ...
Inositol trisphosphate receptor
The initial sequencing was reported as an unknown protein enriched in the cerebellum called P400. The large size of this ... and soon thereafter it was confirmed that the protein p400 was in fact the inositol trisphosphate receptor. ... "Nucleotide sequence of cDNA encoding P400 protein in the mouse cerebellum". Nucleic Acids Res. 17 (13): 5385-6. doi:10.1093/ ... "Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400". Nature. 342 (6245): 32- ...
Structures: Band 3 anion transport protein (P02730) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Solved structures for this protein. ID. Structure. Description. 1btq THE SOLUTION STRUCTURES OF THE FIRST AND SECOND ... STRUCTURAL STUDIES ON THE EFFECTS OF THE DELETION IN THE RED CELL ANION EXCHANGER (BAND3, AE1) ASSOCIATED WITH SOUTH EAST ASIAN ...
RCSB PDB - Protein Feature View - Band 3 anion transport protein - P02730 (B3AT HUMAN)
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... Protein Feature View of PDB entries mapped to a UniProtKB sequence * Number of PDB entries for P78487: no matching PDB entries ... This protein in other organisms (by gene name): P78487 - Homo sapiens 0 * P15575 - Gallus gallus no matching PDB entries ... Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN * ...
Band 3 anion transport protein - Wikipedia
Band 3 anion transport protein is a phylogenetically-preserved transport protein responsible for mediating the exchange of ... Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), ... Diego blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH Band+3+Protein at the US National ... The erythrocyte and kidney forms are different isoforms of the same protein. The erythrocyte isoform of AE1, known as eAE1, is ...
Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2. - PubMed ...
Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2.. Zhou F1, ... Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2 ... Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2 ... Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2 ...
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on...
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on ... Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on ... Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on ... Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on ...
Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus...
4) Our results show that the C-terminus of the red-cell anion transport protein is located on the cytoplasmic side of the red- ... Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus ... Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus ... Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus ...
The 5′-AMP-Activated Protein Kinase Regulates the Function and Expression of Human Organic Anion Transporting Polypeptide 1A2 |...
Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression:...
multidrug resistance associated protein 2. OATP. organic anion-transporting polypeptide. P-gp. P-glycoprotein. PBPK. ... 2012) Membrane protein quantification by peptide-based mass spectrometry approaches: studies on the organic anion-transporting ... Interindividual variability in protein expression of organic anion-transporting polypeptides (OATPs) OATP1B1, OATP1B3, OATP2B1 ... 2012) Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression ...
Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression:...
Interindividual variability in protein expression of organic anion-transporting polypeptides (OATPs) OATP1B1, OATP1B3, OATP2B1 ... Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: ... Interindividual Variability in Hepatic Organic Anion-Transporting Polypeptides and P-Glycoprotein (ABCB1) Protein Expression: ... The mean ± S.D. (maximum/minimum range in parentheses) protein expression (fmol/µg of membrane protein) in human liver tissue ...
The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane, The...
... in transport of fluorescent anions across the human erythrocyte membrane, The Journal of Membrane Biology" on DeepDyve, the ... Transport of organic anions by multidrug resistanceassociated protein in the erythrocyte. Rychlik, B.; Pulaski, L.; Sokal, A.; ... The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the human erythrocyte membrane. ... The role of multidrug resistance protein 1 (MRP1) in transport of fluorescent anions across the... Rychlik, B.; Balcerczyk, A ...
SLC4A1 elisa kit | Human Band 3 anion transport protein (SLC4A1) ELISA Kit-NP 000333.1
Human Band 3 anion transport protein (SLC4A1) ELISA Kit-NP_000333.1 (MBS7230564) product datasheet at MyBioSource, ELISA Kits ... UniProt Protein Name Band 3 anion transport protein UniProt Synonym Protein Names Anion exchange protein 1; AE 1; Anion ... Band 3 anion transport protein (SLC4A1), ELISA Kit. ★Popular Item★ Also Known As Human Band 3 anion transport protein (SLC4A1) ... NCBI Protein Information band 3 anion transport protein; Diego blood group; Swann blood group; anion exchanger 1; anion ...
Domain combinations for Phoshotransferase/anion transport protein superfamily
Domain architectures illustrate each occurrence of the Phoshotransferase/anion transport protein superfamily. ... Domain combinations containing the Phoshotransferase/anion transport protein superfamily . ... 1 domain combinations include a Phoshotransferase/anion transport protein domain in Mycoplasma gallisepticum str. F. With a ... Domain combinations for Phoshotransferase/anion transport protein superfamily. ...
Organic Anion Transport Protein 1 | Profiles RNS
"Organic Anion Transport Protein 1" by people in this website by year, and whether "Organic Anion Transport Protein 1" was a ... Organic Anion Transporters, Sodium-Independent [D12.776.157.530.450.074.500.781]. *Organic Anion Transport Protein 1 [D12.776. ... Organic Anion Transporters, Sodium-Independent [D12.776.543.585.450.074.500.875]. *Organic Anion Transport Protein 1 [D12.776. ... "Organic Anion Transport Protein 1" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ...
Determinants of Subcellular Trafficking of Organic Anion Transport Protein 1a1 (oatp1a1)
Organic anion transporting polypeptides (rodents: Oatps; human: OATPs) are a family of sodium independent solute carriers that ... The proteins and motor molecules that mediate these trafficking events are unknown at present, but represent an important area ... In addition, BSP transport activity for oatp1a1AA significantly increased in the presence of PDZK1 without altering the ...
Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
... and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of ... Carrier Proteins * Membrane Transport Proteins * Organic Anion Transporters, Sodium-Dependent * Symporters * sodium-bile acid ... Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver Hepatology. 1997 Dec;26(6 ... The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters ...
Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis
... is a polytopic membrane protein found in outer hair cells (OHCs) of the mammalian cochlea. Prestin is an essential component of ... a member of the SLC26A family of anion transporters, ... Anion Transport Proteins / genetics * Anion Transport Proteins ... Prestin, a member of the SLC26A family of anion transporters, is a polytopic membrane protein found in outer hair cells (OHCs) ... Essential helix interactions in the anion transporter domain of prestin revealed by evolutionary trace analysis J Neurosci. ...
Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells - edoc
Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells. Journal of biological ... Recently we expression cloned a rat liver organic anion transport protein in Xenopus laevis oocytes (Jacquemin, E. Hagenbuch, B ... Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells ... whereas the induced transfected cells express a novel 74-kDa protein and avidly transport this ligand. Transport by these cells ...
The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1 - edoc
The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1 ... The scaffold protein PDZK1 modulates expression and function of the organic anion transporting polypeptide 2B1. European ... The protein family of Organic Anion Transporting Polypeptides (OATPs) summarizes various transporters known to facilitate ... PDZK1 (PDZ domain-containing 1) is a scaffold protein that influences function of different membrane proteins by sorting/ ...
SWISS-MODEL Template Library | 1bts.1
Transport of anions through neuronal cell-membranes by receptor-channel proteins. :: MPG.PuRe
Transport of anions through neuronal cell-membranes by receptor-channel proteins. ... Transport of anions through neuronal cell-membranes by receptor-channel proteins. Bormann, J. (1987). Transport of anions ... through neuronal cell-membranes by receptor-channel proteins. Biological Chemistry Hoppe-Seyler, 368(10), 1247-1247. ...
Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane :: MPG.PuRe
Anion Transport, Equilibrium Exchange; Modifier Site; Anion Binding ; Title: Molecular aspects of band 3 protein-mediated anion ... Passow, H. (1986). Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane. In Reviews ... Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane ... transport across the red blood cell membrane ...
1bzk.1 | SWISS-MODEL Template Library
STRUCTURAL STUDIES ON THE EFFECTS OF THE DELETION IN THE RED CELL ANION EXCHANGER (BAND3, AE1) ASSOCIATED WITH SOUTH EAST ASIAN ... PROTEIN (BAND 3 ANION TRANSPORT PROTEIN): A. SMTL:PDB. SMTL Chain Id:. PDB Chain Id:. A. A ... Chambers, E.J. et al., Structural studies on the effects of the deletion in the red cell anion exchanger (band 3, AE1) ... STRUCTURAL STUDIES ON THE EFFECTS OF THE DELETION IN THE RED CELL ANION EXCHANGER (BAND3, AE1) ASSOCIATED WITH SOUTH EAST ASIAN ...
Purpose: Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters - Heat Shock Proteins...
Purpose: Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters. Published July 13, ... Purpose: Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters mediating liver ... Manifestation of OATP1B proteins is definitely CCT137690 regulated in the transcriptional [2,8,9] and/or protein level . ... Proteins kinase C II (PKCII) amounts upsurge in the myocardium of * Background The role of advanced glycation end products ( ...
Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation...
title = "Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its ... T1 - Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its ... Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation ... Rat Organic Anion Transport Protein 1A1 Interacts Directly With Organic Anion Transport Protein 1A4 Facilitating Its Maturation ...
The choroid plexus epithelium is the site of the organic anion transport protein in the brain<...
The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proceedings of the National ... The mRNA for organic anion transport protein (oatp) was previously shown to be present in abundance in liver and kidney, and in ... Fingerprint Dive into the research topics of The choroid plexus epithelium is the site of the organic anion transport protein ... The choroid plexus epithelium is the site of the organic anion transport protein in the brain. / Angeletti, Ruth Hogue; ...
Anion translocation through an Slc26 transporter mediates lumen expansion during tubulogenesis | Proceedings of the National...
2012) Anion transport by the cochlear motor protein prestin. J Physiol 590(Pt 2):259-272. ... C) Electrogenic anion transport mediated by Ci-Slc26aα in CHO cells. Transport currents occurred in the presence of either ... Electrogenic anion transport was measured as the ionic transport current in the response to command voltage ramps (300 ms; ∼0.8 ... 2009) Diverse transport modes by the solute carrier 26 family of anion transporters. J Physiol 587(Pt 10):2179-2185. ...
Anion exchange protein 2 - Wikipedia
Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. AE2 is ... Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human ... "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)". Gawenis ... Huang QR, Li Q, Chen YH, Li L, Liu LL, Lei SH, Chen HP, Peng WJ, He M (June 2010). "Involvement of anion exchanger-2 in ...
Molecular alterations of canalicular transport systems in experimental models of cholestasis: possible functional correlations.
ATP-dependent canalicular transport systems (also termed export pumps) for bile salts, amphiphilic anionic conjugates, ... 0/Anion Transport Proteins; 0/Bicarbonates; 0/Bile Acids and Salts; 0/Carrier Proteins; 0/P-Glycoprotein; 0/Phospholipids; 56- ... Anion Transport Proteins. Bicarbonates / metabolism. Bile Acids and Salts / metabolism. Bile Canaliculi / physiopathology*. ... Biological Transport, Active. Carrier Proteins / metabolism. Cholestasis / etiology, genetics, physiopathology*. Cholesterol / ...
Table of Contents - August 01, 1991, 88 (15) | PNAS
Monomeric erythrocyte band 3 protein transports anions. S Lindenthal and D Schubert ... Activation of membrane protein-tyrosine phosphatase involving cAMP- and Ca2+/phospholipid-dependent protein kinases. D L ... Bidirectional control of phospholipase A2 activity by Ca2+/calmodulin-dependent protein kinase II, cAMP-dependent protein ... Human cells contain protein specifically binding to a single 1,N6-ethenoadenine in a DNA fragment. B Rydberg, M K Dosanjh, and ...
Simultaneous Assessment of Uptake and Metabolism in Rat Hepatocytes: A Comprehensive Mechanistic Model | Journal of...
... shows relevant inhibition of organic anion-transporting protein 1B1-mediated transport of atorvastatin. Drug Metab Dispos 38: ... organic anion-transporting protein. ABT. 1-aminobenzotriazole. M1. 2-despiperidyl-2-amino repaglinide. M2. 2-despiperidyl-2(5- ... Organic anion-transporting proteins (OATPs) are expressed on the sinusoidal membrane of hepatocytes and have been identified as ... 2008) Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family. Xenobiotica 38:778-801. ...
TransportersExchangerTransporterPolypeptidesOATPsMolecularBicarbonateBasolateralSecretionOrganic Anion Transporting PolypeptideExchangersMembrane proteinPeptidesExpressionGeneSubstrateSLC4A1MetabolismExchange proteinSubstratesMediatesHepaticHumanMRNASoluteMultidrug resistanceOATP1B3SequenceMembranesPlasma membraneJournal of physiologyCompoundsProximalInhibitionCell membraneMeSHMediateErythrocyte membraneEffluxSubstancesLocalizationBand 3 proteinsPhysiologyAmino AcidsRegulationFamily of proteins
- Inhibitor profiles of CF and BCECF transport are typical for substrates of organic anion transporters. (deepdyve.com)
- The Na+-dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+-independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. (nih.gov)
- Prestin, a member of the SLC26A family of anion transporters, is a polytopic membrane protein found in outer hair cells (OHCs) of the mammalian cochlea. (nih.gov)
- The protein family of Organic Anion Transporting Polypeptides (OATPs) summarizes various transporters known to facilitate cellular uptake of xenobiotics. (unibas.ch)
- Our work reveals the consequences and relationships of several key processes in lumen formation, and establishes an in vivo assay for studying the molecular basis of the transport properties of SLC26 family transporters and their related diseases. (pnas.org)
- Recently, several transmembrane proteins, including transporters, pumps, and channels localized in the developing tubular epithelia, have been implicated in lumen expansion and tube size control ( 3 ). (pnas.org)
- The solute carrier 26 (SLC26) sulfate transporters, so-called because the first member, SLC26A1, was identified as a liver SO 4 2− transporter ( 7 ), compose a family of multidomain transmembrane anion exchangers capable of transporting a wide range of monovalent and divalent anions ( 8 ). (pnas.org)
- Purpose: Organic anion-transporting polypeptides OATP1B1 and OATP1B3 are sinusoidal membrane transporters mediating liver uptake of a wide range of substrates including conjugated and unconjugated bilirubin, xenobiotics and drugs. (neuroart2006.com)
- Adaptive changes in manifestation of liver bilirubin transporters in both hereditary and acquired cholestatic liver diseases-down-regulation of the canalicular multidrug resistance-associated protein MRP2 manifestation and up-regulation of sinusoidal MRP3 expression-explain the impairment of liver bilirubin uptake and excretion [18-22]. (neuroart2006.com)
- Competition experiments indicated that there were two organic anion transporters, one that transports carboxylate compounds, such as PAH and fluorescein, and another that transports sulphonates, such as amaranth and Indigo Carmine. (biologists.org)
- The Oatp family of transporters mediates transport of a variety of substrates, including organic anions, cations, and neutral compounds in a Na + -independent manner. (aspetjournals.org)
- Single-channel recordings on ClC-0 revealed unitary conductances of about 10 pS ( Miller, 1982 ), and since this value predicts a transport rate far above the maximum rates of transporters and pumps there was little doubt that this protein mediates anion diffusion through an aqueous conduction pathway. (frontiersin.org)
- All experimental data presented so far support a close structural similarity of the members of the CLC family and demonstrate that transport proteins of similar structure can specialize into ion channels or transporters. (frontiersin.org)
- A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. (curehunter.com)
- Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. (curehunter.com)
- Activity inhibited by all inhibitors of several anion channels and transporters, including 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS), diphenylamine-2-carboxylic acid and glybenclamide. (uniprot.org)
- Molecular pharmacology of renal organic anion transporters. (semanticscholar.org)
- Structure of renal organic anion and cation transporters. (semanticscholar.org)
- The renal proximal tubule: a model for diversity of anion exchangers and stilbene sensitive anion transporters , Ann. (springer.com)
- Members of the multidrug resistance-associated protein (MRP) family of transporters are believed to contribute to cytotoxic drug resistance and chemotherapy failure. (aacrjournals.org)
- Multidrug resistance (MDR) due to reduced drug accumulation is a phenomenon associated with the overexpression of ATP-binding cassette (ABC) transporters, such as P-glycoprotein (ABCB1), MDR-associated proteins (MRP), and ABCG2 or mitoxantrone resistance-associated protein. (aacrjournals.org)
- We also measure the chloride and proton fluxes through these transporters using electrical recordings in lipid bilayer membranes as a means to probe the functional behavior of these proteins. (nih.gov)
- The chloride channel (CLC) family of Cl − transport proteins includes both Cl − channels and proton-coupled Cl − exchange transporters ( Zifarelli & Pusch 2007 ). (royalsocietypublishing.org)
- Chaperone stress 70 protein (STCH) binds and regulates two acid/base transporters NBCe1-B and NHE1. (springer.com)
- The ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. (wikipathways.org)
- The ABC transporters not only move a variety of substrates into and out of the cell, but are also involved in intracellular compartmental transport. (wikipathways.org)
- On the basis of our finding that OAT4 is an apical organic anion/dicarboxylate exchanger ( 5 ), we suggested that OAT4 mainly functions as an apical entrance pathway for some organic anions in renal proximal tubules driven by an outwardly directed dicarboxylate gradient created by Na + /dicarboxylate co-transporters ( 6 ). (asnjournals.org)
- One possible role of OAT4 is as an apical backflux pathway ( 7 ) for some organic anions such as steroid sulfates, functionally coupled to the apical efflux transporters for organic anions, such as MRP2, MRP4, and NPT1 (putative human homologue of OAT V 1) ( 8 - 13 ). (asnjournals.org)
- Therefore, it is likely that these transporters bind with the same or other PDZ protein(s) via their CT PDZ motifs. (asnjournals.org)
- Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), is a protein that is encoded by the SLC4A1 gene in humans. (wikipedia.org)
- Expression of the anion exchanger (AE) gene family in human brain. (wikipedia.org)
- The Malpighian tubules appeared not to possess an organic acid/ α -keto acid exchanger because PAH accumulation was not affected by low concentrations (100 μmol l(−)(1)) of α -keto acids (α -ketoglutarate, glutarate, citrate and succinate) or the activity of phosphokinase C. PAH transport may be directly coupled to the Na(+) gradient, perhaps via Na(+)/organic acid cotransport. (biologists.org)
- Processing of N-linked oligosaccharide depends on its location in the anion exchanger, AE1, membrane glycoprotein. (semanticscholar.org)
- The human erythrocyte anion exchanger (AE)1 (Band 3) contains a single complex N-linked oligosaccharide that is attached to Asn(642) in the fourth extracellular loop of this polytopic membrane protein, while other isoforms (AE2, AE3 and trout AE1) are N-glycosylated on the preceding extracellular loop. (semanticscholar.org)
- Differential roles of tryptophan residues in the functional expression of human anion exchanger 1 (AE1, Band 3, SLC4A1). (semanticscholar.org)
- Cell surface expression and internalization of the murine erythroid AE1 anion exchanger tagged with an extracellular FLAG epitope. (semanticscholar.org)
- Topology of transmembrane segments 1-4 in the human chloride/bicarbonate anion exchanger 1 (AE1) by scanning N-glycosylation mutagenesis. (semanticscholar.org)
- Calnexin interaction with N-glycosylation mutants of a polytopic membrane glycoprotein, the human erythrocyte anion exchanger 1 (band 3). (semanticscholar.org)
- Transmembrane folding of the human erythrocyte anion exchanger (AE1, Band 3) determined by scanning and insertional N-glycosylation mutagenesis. (semanticscholar.org)
- Belongs to the anion exchanger (TC 2.A.31) family. (abcam.com)
- The SLC4A1 gene provides instructions for making a protein known as anion exchanger 1 (AE1). (medlineplus.gov)
- It thus came as a surprise when a bacterial homolog in E. coli was shown to function as a coupled anion/proton exchanger ( Accardi and Miller, 2004 ). (frontiersin.org)
- Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. (uniprot.org)
- May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger, specifically chloride. (uniprot.org)
- 23.Genomic Cloning and Promoter Analysis of A Mouse Anion Exchanger 3 iAE3 jGene. (seitoku.jp)
- Human organic anion transporter 4 (OAT4) is an apical organic anion/dicarboxylate exchanger in the renal proximal tubules and mediates high-affinity transport of steroid sulfates such as estrone-3-sulfate (E 1 S) and dehydroepiandrosterone sulfate. (asnjournals.org)
- Recently, we reported that the urate/anion exchanger URAT1 ( 18 ), which has a similar PDZ motif (S-T-Q-F) at its C-terminus, interacts with multivalent PDZ protein PDZK1 ( 19 , 20 ). (asnjournals.org)
- Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. (rcsb.org)
- Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. (rcsb.org)
- Ci -Slc26aα acts as an anion transporter, mediating the electrogenic exchange of sulfate or oxalate for chloride or bicarbonate and electroneutral chloride:bicarbonate exchange. (pnas.org)
- Slc21a10) is known as a liver-specific and sodium-independent transporter that mediates transport of a variety of compounds. (aspetjournals.org)
- Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. (medlineplus.gov)
- S-nitrosylation of the mitochondrial carnitine/acylcarnitine transporter (CACT) has been investigated on the native and the recombinant proteins reconstituted in proteoliposomes, and on intact mitochondria. (bireme.br)
- Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene . (wikipedia.org)
- Regulation of human organic anion transporter 1 by ANG II: involvement of protein kinase Calpha. (semanticscholar.org)
- Protein kinase C activation downregulates human organic anion transporter 1-mediated transport through carrier internalization. (semanticscholar.org)
- This gene is a member of a family of sulfate/anion transporter genes. (genecards.org)
- GO annotations related to this gene include secondary active sulfate transmembrane transporter activity and anion:anion antiporter activity . (genecards.org)
- Of all the MRP-class transporter proteins, MRP1 has been the most widely studied and best-characterized and available evidence points to a role for MRP1 in the clinical drug resistance of several malignancies, including neuroblastoma. (aacrjournals.org)
- We have previously shown a close correlation between expression of MYCN and the multidrug transporter protein MRP1 and provided strong evidence of a role for MRP1 (but not MDR1 P-glycoprotein) in mediating the drug-resistant phenotype of this aggressive childhood cancer ( 6 ). (aacrjournals.org)
- ABCG2, also known as the placenta-specific ABC transporter and as the breast cancer resistance protein ( 3 , 4 ), is a "half transporter" that most likely functions as a homodimer or higher form oligomer ( 5 , 6 ) and can efflux a variety of anticancer drugs, including mitoxantrone, doxorubicin, topotecan, and SN-38 ( 7 - 9 ). (aacrjournals.org)
- Mouse models of type 2 diabetes (T2D) have dramatically reduced expression of organic anion transporting polypeptide (OATP)1A1, a transporter expressed in hepatocytes and in the kidneys. (diabetesjournals.org)
- Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression. (uzh.ch)
- Protein kinase C-dependent regulation of human hepatic drug transporter expression. (uzh.ch)
- Aims: Transporter proteins known to mediate multidrug resistance (MDR) in tumour cells-MDR1 P-glycoprotein (P-gp) and multidrug resistance related protein 1 (MRP1)-are thought to be involved in protecting the lungs against inhaled toxic pollutants. (bmj.com)
- Recently, several new transporter family members have been identified-for example, MRP2, MRP3, and breast cancer resistance protein (BCRP). (bmj.com)
- Immunohistochemical staining in tissues from mice, rats, and guinea pigs points to a strong evolutionary conservation for these transporter proteins. (bmj.com)
- The human organic anion transporter OAT4 (encoded by SLC22A11 ) is expressed in the kidney and the placenta and mediates the high-affinity transport of steroid sulfates such as estrone-3-sulfate (E 1 S) and dehydroepiandrosterone sulfate (DHEAS) ( 1 ). (asnjournals.org)
- Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. (nih.gov)
- The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. (nih.gov)
- The organic anion transporting polypeptides (OATPs) are a family of membrane transport proteins capable of transporting an array of structurally diverse endogenous and xenobiotic compounds [1-3]. (thefreedictionary.com)
- Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate. (uzh.ch)
- Octreotide Inhibits the Bilirubin Carriers Organic Anion Transporting Polypeptides 1B1 and 1B3 and the Multidrug Resistance-Associated Protein 2. (uzh.ch)
- Molecular alterations of canalicular transport systems in experimental models of cholestasis: possible functional correlations. (biomedsearch.com)
- Recent cloning of several canalicular transport systems now facilitates studies on their molecular regulation in cholestasis. (biomedsearch.com)
- With the increasing availability of molecular probes for these transport systems in humans, new information on the molecular regulation of canalicular transport proteins in human cholestatic liver diseases is beginning to emerge and should bring new insights into their pathophysiology and treatment. (biomedsearch.com)
- This article gives an overview on molecular alterations of canalicular transport systems in experimental models of cholestasis and discusses the potential implications of these changes for the pathophysiology of cholestasis. (biomedsearch.com)
- This clean mechanistic split within a single protein family-a circumstance unprecedented in membrane biology-presents to the biochemist a fascinating question: how can two very different ion-transport mechanisms, electrodiffusion through a watery pore versus coordinated movement of substrates via conformational cycling, be supported by a common molecular architecture? (royalsocietypublishing.org)
- Solutes removed efficiently by the native kidney but poorly by dialysis include larger molecular compounds such as β 2-microglobulin (B2M) and protein-bound solutes removed by the native kidney via proximal tubular transport mechanisms that are not duplicated by dialysis. (asnjournals.org)
- Band 3 anion transport protein is a phylogenetically-preserved transport protein responsible for mediating the exchange of chloride (Cl−) with bicarbonate (HCO3−) across plasma membranes. (wikipedia.org)
- In addition, ATP-independent canalicular transport systems for glutathione and bicarbonate contribute to (bile acid-independent) bile formation. (biomedsearch.com)
- Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. (semanticscholar.org)
- It exists as a dimer and performs the important function of allowing the efficient transport of bicarbonate across erythrocyte cell membranes in exchange for chloride ion. (umassmed.edu)
- In alpha-intercalated cells, the exchange of bicarbonate through the AE1 protein allows acid to be released from the cell into the urine. (medlineplus.gov)
- Mediates bicarbonate transport (By similarity). (genecards.org)
- Ion transport mechanisms linked to bicarbonate secretion in the esophageal submucosal glands. (springer.com)
- Critical amino acid residues involved in the electrogenic sodium-bicarbonate cotransporter kNBC1-mediated transport. (springer.com)
- and is restricted to human being hepatocytes and the related protein products are localized to the basolateral (sinusoidal) membrane [3-6]. (neuroart2006.com)
- AE2 contributes to basolateral membrane HCO3− transport in the gastrointestinal tract. (wikipedia.org)
- Basolateral PAH transport was inhibited by ouabain and dependent on the Na(+) gradient. (biologists.org)
- There the robust basolateral transport mechanisms in the proximal tubule act to strip these and other compounds from their relatively loose binding sites, sometimes completely in one pass through the kidney ( 12 - 14 ). (asnjournals.org)
- Because of its apical membrane localization in the renal proximal tubules ( 2 ), OAT4 had been presumed to be the apical exit pathway of organic anions that are taken up by the basolateral entrance pathway such as OAT1 and OAT3 ( 3 ). (asnjournals.org)
- Transepithelial ion transport is critically important for luminal fluid secretion and absorption in many tubular structures. (pnas.org)
- PKC regulation of organic anion secretion in perfused S2 segments of rabbit proximal tubules. (semanticscholar.org)
- R. Masereeuw, F. G. M. Russel, and D. S. Miller, "Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy," American Journal of Physiology , vol. 271, no. 6, pp. (hindawi.com)
Organic Anion Transporting Polypeptide5
- Protein kinase C regulates the internalization and function of the human organic anion transporting polypeptide 1A2. (nih.gov)
- The human organic anion transporting polypeptide 1A2 (OATP1A2) is expressed in cells from several regions of the human body, including the kidney, cholangiocytes and the blood-brain barrier, and mediates the cellular flux of various anionic substances, including drugs in clinical use. (nih.gov)
- The SLCO1B3 gene provides instructions for making a protein called organic anion transporting polypeptide 1B3, or OATP1B3. (medlineplus.gov)
- König J, Cui Y, Nies AT, Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. (medlineplus.gov)
- A novel human hepatic organic anion transporting polypeptide (OATP2). (wikipedia.org)
- It is the major integral transmembrane protein of the erythrocyte plasma membrane, comprising 25% of the total membrane protein. (umassmed.edu)
- The Membrane Transport Biophysics Unit focuses on understanding the physical principles governing membrane-protein function. (nih.gov)
- 15.High Incidence of a Polymorphic Variant of Erythrocyte Membrane Protein, Band 3-Memphis,on a Western Japanese Island. (seitoku.jp)
- Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein. (wikipathways.org)
- Two synthetic peptides made to the human OATP8 protein sequence (between residues 648-700). (novusbio.com)
- Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS. (uzh.ch)
- Our aims were to select antibodies suitable for specific detection of both or either of the OATP1B proteins on formalin-fixed paraffin-embedded liver specimens by testing them in OATP1B1- and OATP1B3-transgenic mice and to correlate liver expression of OATP1Bs with both forms of plasma bilirubin, cholestatic markers and histological findings in various forms of biliary and parenchymal liver diseases. (neuroart2006.com)
- Although the picture is far from complete, experimental evidence now exists that decreased or even absent expression of canalicular transport proteins may explain impaired transport function resulting in hyperbilirubinemia and cholestasis. (biomedsearch.com)
- Expression of biologically active human corticosteroid binding globulin by insect cells: acquisition of function requires glycosylation and transport. (pnas.org)
- Six MCs have been sequenced after purification, and many more have been identified from their transport and kinetic properties following heterologous over-expression and reconstitution into liposomes. (springer.com)
- URAT1 mRNA and URAT1 protein expression in rat renal tubular cells were determined by RT-PCR and immunohistochemistry method respectively. (curehunter.com)
- Longer time control involves transcriptional regulation that affects the expression levels of key proteins. (mdpi.com)
- Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. (genecards.org)
- Then, we measured a reduction in the hepatic uptake of these hepatobiliary GBCAs in T2D ob / ob mice, which mirrored significant reductions in the mRNA and protein expression of OATP1A1 and OATP1B2. (diabetesjournals.org)
- Exposure to microcystins is linked to higher levels of oxidative stress, and we coupled the oxidative stress response to the expression of yellow fluorescent protein. (plos.org)
- To study the possible contribution of these proteins and the earlier defined MDR1 and MDR3 P-gp molecules, MRP1, and the major vault protein (MVP) to lung functioning, their expression was analysed in normal lung tissue of humans and several animal species. (bmj.com)
- Methods: Frozen sections of normal lung tissues were examined for the expression of the multidrug resistance associated proteins, using an extended panel of monoclonal antibodies that specifically detect these proteins in immunohistochemical techniques. (bmj.com)
- The augmentation of the transport activity was accompanied by alteration in V max of E 1 S transport via OAT4 and was associated with the increased surface expression level of OAT4 protein. (asnjournals.org)
- 4 ) found the OAT4 protein expression at the fetal side of the syncytiotrophoblasts in the placenta and proposed a role for OAT4 in the placental uptake of fetal-derived steroid sulfates. (asnjournals.org)
- Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. (wikipedia.org)
- The SLC4A1 gene mutations involved in SLC4A1 -associated distal renal tubular acidosis lead to production of altered AE1 proteins that are either stuck inside the cell or trafficked to the wrong side of the cell. (medlineplus.gov)
- In the autosomal dominant form of the condition, gene mutations affect only one copy of the SLC4A1 gene, and normal AE1 protein is produced from the other copy. (medlineplus.gov)
- In autosomal recessive SLC4A1 -associated distal renal tubular acidosis, both copies of the SLC4A1 gene are mutated, so all of the protein produced from this gene is altered and not trafficked correctly. (medlineplus.gov)
- This related gene provides instructions for making a protein called OATP1B1, which has a similar transport function to OATP1B3. (medlineplus.gov)
- p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors. (uniprot.org)
- SLC26A1 (Solute Carrier Family 26 Member 1) is a Protein Coding gene. (genecards.org)
- The ras-related ypt protein is an ubiquitous eukaryotic protein: Isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene. (mpg.de)
- The murine homeo box gene product, Hox 1.1 protein, is growth-controlled and associated with chromatin. (mpg.de)
- In addition, BSP transport activity for oatp1a1AA significantly increased in the presence of PDZK1 without altering the affinity of the substrate for oatp1a1 as shown by unchanged Km. (yu.edu)
- To understand the consequences of impaired citrate transport on metabolism, the substrate specificity was also determined, showing that the human citrate carrier predominantly transports citrate, isocitrate, cis-aconitate, phosphoenolpyruvate and malate. (bireme.br)
- NO competed also with NEM, correlating well with previous data showing interference of NEM with the substrate transport path. (bireme.br)
- This method is, however, limited by the space available to the substrate, its specific activity and total radioactivity, the efficiency and speed of separation relative to the actual transport rates, as well as by the capacity of the biological system to retain its structural integrity during separation steps. (springer.com)
- Caveolae, which is a special lipid raft structure formed from cell membrane invagination, was enriched in cholesterol and sphingomyelin, and primarily played the important role in membrane transport , signal transduction, substrate transport and endocytosis (Martin, 2013). (thefreedictionary.com)
- Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cytochrome P450 - arranged by substrate type . (genecards.org)
- In spite of this, we observed that NSC73306 is a transport substrate for ABCG2 that can effectively inhibit ABCG2-mediated drug transport and reverse resistance to both mitoxantrone and topotecan in ABCG2-expressing cells. (aacrjournals.org)
- Dr Jennifer Greaves , Coventry University, Investigating the function and substrate interaction network of ABHD16A, a novel regulator of protein S-acylation. (acmedsci.ac.uk)
- Energy derived from the hydrolysis of ATP is used to transport the substrate across the membrane against a concentration gradient. (wikipathways.org)
- MBS7230564 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Band 3 anion transport protein (SLC4A1) ELISA Kit target analytes in biological samples. (mybiosource.com)
- Studies suggest that with the help of glycophorin A, the altered AE1 protein can often get to the cell membrane in red blood cells, which explains why most people with SLC4A1 -associated distal renal tubular acidosis do not have blood cell abnormalities. (medlineplus.gov)
- 23) Genes associated with membrane transport , the vascular system, and with lipid metabolism are also involved. (thefreedictionary.com)
- The book is organized in five large sections covering nutrition, membrane transport and signaling, cellular respiration, metabolism of different classes of biomolecules, and the workings of DNA in the life cycle of the cell. (thefreedictionary.com)
- Although a large number of studies have described that botanical supplements interfere with drug metabolism, the mode of their interaction with drug transport processes is not well described. (mdpi.com)
- AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein. (wikipedia.org)
- A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. (pnas.org)
- This graph shows the total number of publications written about "Anion Exchange Protein 1, Erythrocyte" by people in this website by year, and whether "Anion Exchange Protein 1, Erythrocyte" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Anion Exchange Protein 1, Erythrocyte" by people in Profiles. (umassmed.edu)
- Several polymorphisms in OATP1B1 and OATP1B3 are known to impact kinetics and disposition to transport numerous OATP1B substrates of either endogenous or exogenous source [10-13]. (neuroart2006.com)
- OATP1A1 and OATP1B2 both transport endogenous substrates such as bile acids and hormone conjugates as well as numerous drugs including gadoxetate disodium (Gd-EOB-DTPA). (diabetesjournals.org)
- The maximal transport activity (MTA) of each OATP in human liver was predicted from transport kinetics and protein quantification. (nih.gov)
- Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. (biochemj.org)
- 1) We have prepared murine monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein (band 3). (biochemj.org)
- Bartosz, G. 2002-03-25 00:00:00 We employed human red blood cells as a model system to check the affinity of MRP1 (Multi-drug Resistance-associated Protein 1) towards fluorescein and a set of its carboxyl derivatives: 5/6-carboxyfluorescein (CF), 2′,7′-bis-(2-carboxyethyl)-5/6-carboxyfluorescein (BCECF) and calcein (CAL). (deepdyve.com)
- N-glycosylation and topology of the human SLC26 family of anion transport membrane proteins. (semanticscholar.org)
- The CLC family encompasses nine human CLC proteins, ClC-1 through −7 and the ClC-Ka and -Kb proteins. (frontiersin.org)
- A phylogram demonstrates the early separation of the human CLC proteins into one branch of chloride channels encompassing ClC-1, ClC-2, ClC-Ka, and ClC-Kb. (frontiersin.org)
- The human multidrug resistance-associated proteins (MRP) are a family of transport proteins that seem to play a critical role in cellular detoxification. (aacrjournals.org)
- 5.Conformstional Change of Band 3 Protein Induced by Diethyl Pyrocarbonate Modification in Human Erythrocyte Ghosts. (seitoku.jp)
- 8.Palmitoylation of Cysteine 69 from the COOH-terminal of Band 3 Protein in the Human Erythrocyte Membrane. (seitoku.jp)
- 14.A Structural Study of the Carboxyl Terminal Region of Human Erythrocyte Band 3 Protein. (seitoku.jp)
- 8:45 am] BILLING CODE 4140-01-P DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Prospective Grant of Exclusive Patent License: Inhibition of Plasmodial Surface Anion Channels for the Treatment or Prevention of Malaria AGENCY: National Institutes of Health, HHS. (justia.com)
- ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. (wikipathways.org)
- K. M. Morshed and K. E. McMartin, "Reabsorptive and secretory 5-methyltetrahydrofolate transport pathways in cultured human proximal tubule cells," American Journal of Physiology , vol. 272, no. 3, pp. (hindawi.com)
- The mRNA for organic anion transport protein (oatp) was previously shown to be present in abundance in liver and kidney, and in small amounts in brain. (elsevier.com)
- Here we identify a solute carrier 26 (Slc26) family protein as an essential regulator of tubulogenesis using the notochord of the invertebrate chordate Ciona intestinalis as a model. (pnas.org)
- Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). (curehunter.com)
- Western blotting analysis revealed that SLT-II did not alter the levels of multidrug resistance-associated protein 2 (Mrp2) and P-glycoprotein in kidneys 24 h after injection, assuming the lack of involvement of Mrp2 and P-glycoprotein in SLT-II-induced acute renal tubular injury and renal handling of LVX observed 24 h after SLT-II injection. (asm.org)
- Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis. (uzh.ch)
- Inhibition potency of all 225 compounds on OATP1B1 (a), OATP1B3 (b), and OATP2B1 mediated transport (c) at a concentration of 20 μM. (nih.gov)
- For example, the OATP1B3 protein transports bilirubin, which is a yellowish substance that is produced when red blood cells are broken down. (medlineplus.gov)
- The OATP1B3 protein also transports certain hormones, toxins, and drugs into the liver for removal from the body. (medlineplus.gov)
- In some cases, the condition is caused by a deletion of genetic material that removes parts of both the SLCO1B3 and SLCO1B1 genes, so no functional OATP1B3 or OATP1B1 protein is made. (medlineplus.gov)
- Most mutations that cause Rotor syndrome lead to abnormally short, nonfunctioning OATP1B3 and OATP1B1 proteins. (medlineplus.gov)
- Analysis of sequence homologies and of folding of the protein in the membrane. (springer.com)
- Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins. (curehunter.com)
- Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
- Moreover, the present invention relates to methods of inducing bone formation by transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding LIM mineralization protein. (google.com)
- In a particular embodiment, the invention provides a method of fusing a spine by transfecting osteogenic precursor cells with an isolated nucleic acid molecule having a nucleotide sequence encoding LIM mineralization protein, admixing the transfected osteogenic precursor cells with a matrix and contacting the matrix with the spine. (google.com)
- 1. A method of inducing bone formation comprising transfecting osteogenic precursor cells with an isolated nucleic acid molecule comprising a nucleotide sequence encoding LIM mineralization protein, wherein said nucleic acid molecule is SEQ ID NO: 22 or SEQ ID NO: 33. (google.com)
- Acylation Occurs in the Middle of the Consensus Sequence of F--I-IICLAVL Found in Band 3 Protein and G2 Protein of Rift Valley Fever Virus. (seitoku.jp)
- At the extreme C-terminal (CT) end, OAT4 has a specific protein-protein interaction peptide sequence named the PDZ (PSD-95/Discs Large/ZO-1) motif (S-T-S-L) ( 14 ). (asnjournals.org)
- however, the bivalent form of one of the antibodies reduced the inhibitory potency of 4-acetamido-4'-isothiocyanatostilbene disulphonate on sulphate exchange transport in resealed erythrocyte membranes. (biochemj.org)
- Transport of anions through neuronal cell-membranes by receptor-channel proteins. (mpg.de)
- A ubiquitous membrane transport protein found in the plasma membrane of diverse cell types and tissues, and in nuclear, mitochondrial, and Golgi membranes. (umassmed.edu)
- This protein transports negatively charged atoms (anions) across cell membranes. (medlineplus.gov)
- However, some altered AE1 proteins cannot be helped by glycophorin A and are not trafficked to red blood cell membranes. (medlineplus.gov)
- Anion channels are membrane-bound proteins that facilitate the energetically passive transport of anions across membranes. (frontiersin.org)
- A family of proteins involved in the transport of monocarboxylic acids such as LACTIC ACID and PYRUVIC ACID across cellular membranes. (harvard.edu)
- Sidedness of inhibitory effects as evidence for asymmetric location of the anion transport system of red blood cell membranes , Fed. (springer.com)
- 6.Anion Transport Center of Band 3 in Erythrocyte Membranes. (seitoku.jp)
- Transport proteins are proteins within the membranes of cells that transport substances such as molecules and ions across the membrane or within the cell, or can be involved in vesicular transport . (wikidoc.org)
- They transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. (wikipathways.org)
- Physical linkage of the plasma membrane to the underlying membrane skeleton (via binding with ankyrin and protein 4.2). (wikipedia.org)
- PDZK1 associates with rOATP1A1-containing endocytic vesicles within cells, mediating recruitment of motor proteins required for microtubule-based trafficking to the plasma membrane. (elsevier.com)
- Plant cells generate a negative electrical potential difference across the plasma membrane and the tonoplast such that anion channels generally mediate anion movement from the cytosol to the apoplast or into the vacuole. (frontiersin.org)
Journal of physiology1
- D. S. Miller, "Protein kinase C regulation of organic anion transport in renal proximal tubule," American Journal of Physiology , vol. 274, no. 1 43-1, pp. (hindawi.com)
- Fluorescein is transported mainly in a passive way, while active efflux systems at least partially contribute to the transport of the other compounds. (deepdyve.com)
- it transports compounds from the blood into the liver so that they can be cleared from the body. (medlineplus.gov)
- The most prominent mechanism known for transporting lipid-soluble compounds ( e.g. , fatty acids) involves noncovalent binding to serum albumin. (asnjournals.org)
- The prospective exclusive license territory may be worldwide and the field of use may be limited to: ''Methods of preventing and/or treating malaria infection by inhibition of Plasmodium Surface Anion Channels (PSAC) with anti-PSAC compounds. (justia.com)
- 1989 ). Anion transport through the contraluminal cell membrane of renal proximal tubule. (biologists.org)
- Protein kinase C regulation of organic anion transport in renal proximal tubule. (semanticscholar.org)
- OAT4, PDZK1, and NHERF1 proteins were shown to be localized at the apical membrane of renal proximal tubules. (asnjournals.org)
- This study indicates that the functional activity of OAT4 is modulated through the PDZ interaction with the network of PDZK1 and NHERF1 and suggests that OAT4 is involved in the regulated apical organic anion handling in the renal proximal tubules, provided by the PDZ scaffold. (asnjournals.org)
- Both URAT1 and OAT4 are considered to function to generate a reabsorptive pathway for organic anions localized at the apical membrane of renal proximal tubules. (asnjournals.org)
- The half inhibition constant (IC50) was very similar for the native and recombinant proteins, i.e., 74 and 71 M, respectively. (bireme.br)
- Insights into the ClC-4 transport mechanism from studies of Zn2+ inhibition. (nih.gov)
- 7.Inhibition of Chlorode Binding to the Anion Transport Site by Diethylpyro-carbonate Modification of Band 3. (seitoku.jp)
- 4) Our results show that the C-terminus of the red-cell anion transport protein is located on the cytoplasmic side of the red-cell membrane. (biochemj.org)
- However, the altered protein attaches to the normal protein and keeps it from getting to the correct location, leading to a severe reduction or absence of AE1 protein in the correct part of the cell membrane. (medlineplus.gov)
- Organic Anion Transport Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- The proteins and motor molecules that mediate these trafficking events are unknown at present, but represent an important area for future study. (yu.edu)
- required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. (rcsb.org)
- We found significant differences in the characteristics of transport of the dyes tested across the erythrocyte membrane. (deepdyve.com)
- Some members of the family function as aluminum (Al 3+ )-activated anion channels which protect the roots from aluminum toxicity by facilitating malate efflux from the root apices. (frontiersin.org)
- coli inner membrane transport for improved efflux of biofuel molecules, and generating phenotypic diversity in a fungal biocatalyst. (thefreedictionary.com)
- 2015). Na+-Dependent Anion Transport by a Barley Efflux Protein Revealed through an Integrative Platform. (plantcell.org)
- The albumin-binding defect itself could have adverse consequences independent of the toxicity of accumulated ligands if transport of other vital but not necessarily toxic substances is impaired. (asnjournals.org)
- Standard thrice-weekly dialysis has limited potential to remove protein-bound substances, but increasing the dialysis membrane area and/or increasing the dialysate flow can augment removal of bound IS and PCS, especially if applied to prolonged nocturnal dialysis, which has been shown to double IS and PCS clearance without change in urea clearance ( 18 , 19 ). (asnjournals.org)
- PDZK1 (PDZ domain-containing 1) is a scaffold protein that influences function of different membrane proteins by sorting/stabilization of their membrane localization. (unibas.ch)
- Previous studies showed that rat OATP1A1 (rOATP1A1) has a postsynaptic density protein, drosophila disc large tumor suppressor, zonula occludens-1 protein (PDZ) consensus binding motif at its C-terminus and binds to PDZ domain containing 1 (PDZK1), which is required for its cell-surface localization. (elsevier.com)
- This localization of oatp is consistent with previous experiments showing vectorial transport of organic anions between the choroid plexus and the cerebrospinal fluid. (elsevier.com)
Band 3 proteins1
- These mutations are disease causing as they cause mistargetting of the mutant band 3 proteins so that they are retained within the cell or occasionally addressed to the wrong (i.e. apical) surface. (wikipedia.org)
- The discovery of unidirectional, ATP-dependent canalicular transport systems (also termed "export pumps") for bile salts, amphiphilic anionic conjugates, lipophilic cations, and phospholipids has opened new opportunities for understanding biliary physiology and the pathophysiology of cholestasis. (biomedsearch.com)
- 3) One of the antibodies reacts with an epitope present on a cytoplasmic loop of the protein located between the C-terminus and a point 168 amino acids from the C-terminus. (biochemj.org)
- All MCs of known function belong to the same protein family, since their polypeptide chains consist of three tandemly related sequences of about 100 amino acids, and the repeats of the different carriers are homologous. (springer.com)
- System L is a major transport system for cellular uptake of neutral amino acids. (nii.ac.jp)
- In the present study the role of protein kinase C (PKC) in the regulation of OATP1A2 was investigated in an in vitro cell model. (nih.gov)
- Conclusions: Down-regulation of OATP1B proteins may contribute to pathogenesis of jaundice accompanying advanced cholestatic liver diseases. (neuroart2006.com)
- The experimental data indicate that acetylation of CACT inhibits its transport activity, and thus may contribute to the regulation of the mitochondrial -oxidation pathway. (bireme.br)
- Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells. (semanticscholar.org)
- 21.Calmodulin Binds to inv Protein: Implication for the Regulation of inv Function. (seitoku.jp)
Family of proteins1
- Specifically, the invention concerns a novel family of proteins, and nucleic acids encoding those proteins, that enhances the efficacy of bone mineralization in vitro and in vivo. (google.com)