Viscosity: The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Latex: A milky, product excreted from the latex canals of a variety of plant species that contain cauotchouc. Latex is composed of 25-35% caoutchouc, 60-75% water, 2% protein, 2% resin, 1.5% sugar & 1% ash. RUBBER is made by the removal of water from latex.(From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). Hevein proteins are responsible for LATEX HYPERSENSITIVITY. Latexes are used as inert vehicles to carry antibodies or antigens in LATEX FIXATION TESTS.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Spectrin: A high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane.Erythrocyte Membrane: The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Membranes: Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.Membrane Lipids: Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.Intracellular Membranes: Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.Membrane Potentials: The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Naphthols: Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications.Bicarbonates: Inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity.HEPES: A dipolar ionic buffer.Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.Spacecraft: Devices, manned and unmanned, which are designed to be placed into an orbit about the Earth or into a trajectory to another celestial body. (NASA Thesaurus, 1988)Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Erythrocyte Aging: The senescence of RED BLOOD CELLS. Lacking the organelles that make protein synthesis possible, the mature erythrocyte is incapable of self-repair, reproduction, and carrying out certain functions performed by other cells. This limits the average life span of an erythrocyte to 120 days.Anion Exchange Protein 1, Erythrocyte: A major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.Cell Aging: The decrease in the cell's ability to proliferate with the passing of time. Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. The cell enters a quiescent state after which it experiences CELL DEATH via the process of APOPTOSIS.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Antigens: Substances that are recognized by the immune system and induce an immune reaction.Antigens, Surface: Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antigens, Bacterial: Substances elaborated by bacteria that have antigenic activity.Wheat Germ Agglutinins: Lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Triticum: A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Solute Carrier Family 12, Member 4: K-Cl cotransporter ubiquitously expressed with higher expression levels in ERYTHROCYTES of ANEMIA, SICKLE CELL. It mediates active potassium and chloride cotransport across the plasma membrane and contributes to cell volume homeostasisSolute Carrier Family 12, Member 3: Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.Antiporters: Membrane transporters that co-transport two or more dissimilar molecules in the opposite direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient.Anion Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of negatively charged molecules (anions) across a biological membrane.SLC4A Proteins: Bicarbonate transporters that move BICARBONATE IONS in exchange of CHLORIDE IONS or SODIUM IONS across membranes. They regulate acid-base HOMEOSTASIS, cell volume and intracellular pH. Members include CHLORIDE-BICARBONATE ANTIPORTERS (SLC4A1, 2, 3, and 9); SODIUM-COUPLED BICARBONATE TRANSPORTERS (SLC4A4 and 5, 7, 8 and 10); and a sodium borate cotransporter (SLC4A11 protein).Cation Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.Chloride-Bicarbonate Antiporters: Electroneutral chloride bicarbonate exchangers that allow the exchange of BICARBONATE IONS exchange for CHLORIDE IONS across the cellular membrane. The action of specific antiporters in this class serve important functions such as allowing the efficient exchange of bicarbonate across red blood cell membranes as they passage through capillaries and the reabsorption of bicarbonate ions by the kidney.Membrane Transport Proteins: Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.Anions: Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.Nucleotide Transport Proteins: Proteins involved in the transport of NUCLEOTIDES across cellular membranes.

Topology of the membrane domain of human erythrocyte anion exchange protein, AE1. (1/661)

Anion exchanger 1 (AE1) is the chloride/bicarbonate exchange protein of the erythrocyte membrane. By using a combination of introduced cysteine mutants and sulfhydryl-specific chemistry, we have mapped the topology of the human AE1 membrane domain. Twenty-seven single cysteines were introduced throughout the Leu708-Val911 region of human AE1, and these mutants were expressed by transient transfection of human embryonic kidney cells. On the basis of cysteine accessibility to membrane-permeant biotin maleimide and to membrane-impermeant lucifer yellow iodoacetamide, we have proposed a model for the topology of AE1 membrane domain. In this model, AE1 is composed of 13 typical transmembrane segments, and the Asp807-His834 region is membrane-embedded but does not have the usual alpha-helical conformation. To identify amino acids that are important for anion transport, we analyzed the anion exchange activity for all introduced cysteine mutants, using a whole cell fluorescence assay. We found that mutants G714C, S725C, and S731C have very low transport activity, implying that this region has a structurally and/or catalytically important role. We measured the residual anion transport activity after mutant treatment with the membrane-impermeant, cysteine-directed compound, sodium (2-sulfonatoethyl)methanethiosulfonate) (MTSES). Only two mutants, S852C and A858C, were inhibited by MTSES, indicating that these residues may be located in a pore-lining region.  (+info)

Structural and functional consequences of antigenic modulation of red blood cells with methoxypoly(ethylene glycol). (2/661)

We previously showed that the covalent modification of the red blood cell (RBC) surface with methoxypoly(ethylene glycol) [mPEG; MW approximately 5 kD] could significantly attenuate the immunologic recognition of surface antigens. However, to make these antigenically silent RBC a clinically viable option, the mPEG-modified RBC must maintain normal cellular structure and functions. To this end, mPEG-derivatization was found to have no significant detrimental effects on RBC structure or function at concentrations that effectively blocked antigenic recognition of a variety of RBC antigens. Importantly, RBC lysis, morphology, and hemoglobin oxidation state were unaffected by mPEG-modification. Furthermore, as shown by functional studies of Band 3, a major site of modification, PEG-binding does not affect protein function, as evidenced by normal SO4- flux. Similarly, Na+ and K+ homeostasis were unaffected. The functional aspects of the mPEG-modified RBC were also maintained, as evidenced by normal oxygen binding and cellular deformability. Perhaps most importantly, mPEG-derivatized mouse RBC showed normal in vivo survival ( approximately 50 days) with no sensitization after repeated transfusions. These data further support the hypothesis that the covalent attachment of nonimmunogenic materials (eg, mPEG) to intact RBC may have significant application in transfusion medicine, especially for the chronically transfused and/or allosensitized patient.  (+info)

Volume expansion stimulates p72(syk) and p56(lyn) in skate erythrocytes. (3/661)

Hypotonic volume expansion of skate erythrocytes rapidly stimulates the tyrosine phosphorylation of band 3, the membrane protein thought to mediate the osmotically sensitive taurine efflux. Skate erythrocytes possess numerous tyrosine kinases including p59fyn, p56lyn, pp60(src), and p72(syk), demonstrated by immune complex assays measuring autocatalytic kinase activity. Inclusion of the cytoplasmic domain of band 3 in this assay showed that only Syk and Lyn can directly phosphorylate the cytoplasmic domain of band 3. Upon cell volume expansion, Syk activity was increased as assessed by three different assays (immune complex assay measuring autophosphorylation, assay of the level of phosphotyrosine of the immunoprecipitated kinase, and assay of level of 32P in the kinase immunoprecipitated from cells prelabeled with 32PO4 and then volume-expanded). The tyrosine kinase Lyn was also stimulated by volume expansion, most notably when analyzed by the latter two methods. Volume expansion stimulated a large increase in the ability of Syk to phosphorylate band 3 at times that coincide with the stimulation of taurine flux. The stilbene piceatannol inhibited Syk preferentially over Lyn and other tyrosine kinases and inhibited volume-stimulated taurine efflux in a concentration-dependent manner similar to that for the inhibition of Syk. Two major phosphorylation peaks were detected in tryptic digests of cdb3 separated by reverse phase HPLC. Edman degradation demonstrated a phosphotyrosine in a YXXL motif. In conclusion, p72(syk) appears to be a strong candidate as a pivotal signal-transducing step in the volume-activated taurine efflux in skate red cells. The level of band-3 phosphorylation may be regulated, in addition, by a protein-tyrosine phosphatase of the 1B variety.  (+info)

Hydrodynamic properties of human erythrocyte band 3 solubilized in reduced Triton X-100. (4/661)

The oligomeric state and function of band 3, purified by sulfhydryl affinity chromatography in reduced Triton X-100, was investigated. Size exclusion high-performance liquid chromatography showed that a homogeneous population of band 3 dimers could be purified from whole erythrocyte membranes. The elution profile of band 3 purified from membranes that had been stripped of its cytoskeleton before solubilization was a broad single peak describing a heterogeneous population of oligomers with a mean Stokes radius of 100 A. Sedimentation velocity ultracentrifugation analysis confirmed particle heterogeneity and further showed monomer/dimer/tetramer equilibrium self-association. Whether the conversion of dimer to the form described by a Stokes radius of 100 A was initiated by removal of cytoskeletal components, alkali-induced changes in band 3 conformation, or alkali-induced loss of copurifying ligands remains unclear. After incubation at 20 degrees C for 24 h, both preparations of band 3 converted to a common form characterized by a mean Stokes radius of 114 A. This form of the protein, examined by equilibrium sedimentation ultracentrifugation, is able to self-associate reversibly, and the self-association can be described by a dimer/tetramer/hexamer model, although the presence of higher oligomers cannot be discounted. The ability of the different forms of the protein to bind stilbene disulfonates revealed that the dimer had the highest inhibitor binding affinity, and the form characterized by a mean Stokes radius of 114 A to have the lowest.  (+info)

Decreased plasma membrane thiol concentration is associated with increased osmotic fragility of erythrocytes in zinc-deficient rats. (5/661)

Zinc deficiency leads to pathological signs that are related to impaired function of plasma membrane proteins. The purpose of this study was to assess the effect of dietary zinc status on the sulfhydryl (SH) content of erythrocyte plasma membranes and erythrocyte function. Three experiments were performed. In the first, immature male rats were fed for 21 d either a low-zinc (<1.0 mg/kg) diet free choice (-ZnAL), an adequate-zinc (100 mg/kg) diet free choice (+ZnAL), or the adequate-zinc diet limited to the intake of -ZnAL pair-mates (+ZnPF). Tail blood was sampled to measure osmotic fragility and SH concentration of erythrocyte membrane proteins. The zinc-deficient rats were then repleted for 2 d and erythrocytes assayed for fragility and SH content. In the second experiment blood was sampled at 3-d intervals to determine the time course of change in fragility and SH concentration. In the third experiment the SH concentration of erythrocyte band 3 protein and the binding of zinc to isolated plasma membranes were measured. SH concentration decreased from approximately 75 nmol/mg protein to 68 nmol/mg protein during 21 d of depletion and returned to control level within 2 d of repletion. There was an inverse relationship between osmotic fragility and SH concentration of erythrocyte membrane proteins. Maximal decrease in SH occurred within 6 d of consuming the low-zinc diet. The SH content of band 3 protein isolated from deficient rats was also significantly lower than that of pair-fed controls (45 vs. 51 nmol/mg protein). The zinc-binding affinity of plasma membrane proteins tended to be decreased by zinc deficiency. In summary, low-zinc status lowers the plasma membrane SH concentration, and the decreased reducing potential is inversely related to osmotic fragility, and presumably, with impaired volume recovery of erythrocytes.  (+info)

Splenic but not thymic autoreactive T cells from New Zealand Black mice respond to a dominant erythrocyte Band 3 peptide. (6/661)

Previous work from our laboratory suggested that erythrocyte Band 3 peptide 861-874 is the dominant epitope recognized by splenic T cells from adult New Zealand Black (NZB) mice that are developing autoimmune haemolytic anaemia (AIHA). Here, it is shown that splenic T cells from 6-week-old NZB mice mount a vigorous in vitro proliferative response to peptide 861-874 and some other selected Band 3 peptides. As the donors grow older, splenic T cells respond to an increasing number of Band 3 peptides and the magnitude of their response also becomes greater. Splenic T cells from 3-week-old NZB mice still responded vigorously to peptide 861-874 and Band 3. By contrast, neither thymocytes nor single-positive CD4-enriched thymus cells from NZB mice responded to peptide 861-874 or Band 3, although they responded to concanavalin A (Con A). However, thymocytes from mice expressing a transgenic T-cell receptor (TCR)-specific for myelin basic protein (MBP) peptide Ac 1-9 responded vigorously to Ac 1-9. It is considered that the T-cell response of NZB mice to Band 3 is initially focused on peptide 861-874 and later spreads to other Band 3 peptides as the disease progresses and that peptide 861-874-reactive T cells are primed in the periphery rather than the thymus.  (+info)

Mapping of a palmitoylatable band 3-binding domain of human erythrocyte membrane protein 4.2. (7/661)

Evidence accumulated over the years suggests that human erythrocyte membrane protein 4.2 is one of the proteins involved in strengthening the cytoskeleton-membrane interactions in the red blood cell. Deficiency of protein 4.2 is linked with a variety of hereditary haemolytic anaemia. However, the interactions of protein 4.2 with other proteins of the erythrocyte membrane remain poorly understood. The major membrane-binding site for protein 4.2 resides on the cytoplasmic domain of band 3 (CDB3). In order to carry out an initial characterization of its interaction with the CDB3, protein 4. 2 was subjected to proteolytic cleavage and gel renaturation assay, and the 23-kDa N-terminal domain was found to interact with band 3. This domain contained two putative palmitoylatable cysteine residues, of which cysteine 203 was identified as the palmitoylatable cysteine. Recombinant glutathione S-transferase-fusion peptides derived from this domain were characterized with respect to their ability to interact with the CDB3. Whereas these studies do not rule out the involvement of other subsites on protein 4.2 in interaction with the CDB3, the evidence suggests that the region encompassing amino acid residues 187-211 is one of the domains critical for the protein 4.2-CDB3 interaction. This is also the first demonstration that palmitoylation serves as a positive modulator of this interaction.  (+info)

Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. (8/661)

Protein 4.2 is a major component of the red blood cell (RBC) membrane skeleton. We used targeted mutagenesis in embryonic stem (ES) cells to elucidate protein 4.2 functions in vivo. Protein 4. 2-null (4.2(-/-)) mice have mild hereditary spherocytosis (HS). Scanning electron microscopy and ektacytometry confirm loss of membrane surface in 4.2(-/-) RBCs. The membrane skeleton architecture is intact, and the spectrin and ankyrin content of 4. 2(-/-) RBCs are normal. Band 3 and band 3-mediated anion transport are decreased. Protein 4.2(-/-) RBCs show altered cation content (increased K+/decreased Na+)resulting in dehydration. The passive Na+ permeability and the activities of the Na-K-2Cl and K-Cl cotransporters, the Na/H exchanger, and the Gardos channel in 4. 2(-/-) RBCs are significantly increased. Protein 4.2(-/-) RBCs demonstrate an abnormal regulation of cation transport by cell volume. Cell shrinkage induces a greater activation of Na/H exchange and Na-K-2Cl cotransport in 4.2(-/-) RBCs compared with controls. The increased passive Na+ permeability of 4.2(-/-) RBCs is also dependent on cell shrinkage. We conclude that protein 4.2 is important in the maintenance of normal surface area in RBCs and for normal RBC cation transport.  (+info)

*List of MeSH codes (D12.776.543)

... hiv envelope protein gp41 MeSH D12.776.543.550.190.110 -- anion exchange protein 1, erythrocyte MeSH D12.776.543.550.190.276 ... erythrocyte MeSH D12.776.543.585.450.162.234 -- organic anion transport protein 1 MeSH D12.776.543.585.450.162.235 -- ... sodium-phosphate cotransporter proteins, type iii MeSH D12.776.543.585.450.162.110 -- anion exchange protein 1, erythrocyte ... anion exchange protein 1, erythrocyte MeSH D12.776.543.550.190.442 -- potassium-hydrogen antiporters MeSH D12.776.543.550. ...

*List of MeSH codes (D12.776.157)

... anion exchange protein 1, erythrocyte MeSH D12.776.157.530.450.162.276 -- potassium-hydrogen antiporters MeSH D12.776.157.530. ... erythrocyte MeSH D12.776.157.530.450.162.193 -- chloride-bicarbonate antiporters MeSH D12.776.157.530.450.162.193.500 -- ... organic anion transport polypeptide c MeSH D12.776.157.530.450.074.500.781.750 -- organic anion transport protein 1 MeSH ... anion transport proteins MeSH D12.776.157.530.450.074.249 -- halorhodopsins MeSH D12.776.157.530.450.074.500 -- organic anion ...

*Cotransporter

... anion transport protein. This cotransporter is an important integral protein in mammalian erythrocytes and moves chloride ion ... The sodium-calcium exchanger exchanges 3 sodium ions for 1 calcium ion and represents a cation antiporter. Cells also contain ... The NKCC1 cotransport protein is found throughout the body but NKCC2 is found only in the kidney and removes the sodium, ... The four known KCC proteins team up to form two separate subfamilies with KCC1 and KCC3 pairing together and KCC2 and KCC4 ...

*SLC4A2

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. AE2 is ... "Entrez Gene: SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)". Gawenis ... Gehrig H, Müller W, Appelhans H (1992). "Complete nucleotide sequence of band 3 related anion transport protein AE2 from human ... Jöns T, Drenckhahn D (1998). "Anion exchanger 2 (AE2) binds to erythrocyte ankyrin and is colocalized with ankyrin along the ...

*SLC26A3

It is different from the anion exchanger that present in erythrocytes, renal tubule, and several other tissues. The protein ... It mediates chloride and bicarbonate exchange and additionally transports sulfate and other anions at the apical membrane, part ... The downregulated-in-adenoma (DRA) is a membrane protein in intestinal cells. It is an anion exchanger and a member of the ... exchange to Na+/H+ exchange". Biochemistry. 41 (41): 12336-42. doi:10.1021/bi0259103. PMID 12369822. Chernova MN, Jiang L, ...

*Southeast Asian ovalocytosis

The increased rigidity of the erythrocyte membrane in SAO is thought to reduce the capacity of the band 3 proteins to cluster ... general rigidity of the cell membrane Loss of sensitivity to substances that cause spiculation of cells Reduced anion exchange ... Rather, the defect lies in a protein known as the band 3 protein, which lies in the cell membrane itself. The band 3 protein ... increased tyrosine phosphorylation of the band 3 protein, reduced sulfate anion transport through the cell membrane, and more ...

*Hydroxycarbamide

Hydroxyurea has also been prepared by converting a quaternary ammonium anion exchange resin from the chloride form to the ... Hydroxyurea lay dormant for more than fifty years until it was studied as part of an investigation into the toxicity of protein ... Antisickling Agents - Agents used to prevent or reverse the pathological events leading to sickling of erythrocytes in sickle ... ISBN 978-1-4144-0362-5. Platt OS (2008). "Hydroxyurea for the treatment of sickle cell anemia". N. Engl. J. Med. 358 (13): 1362 ...

*Anion exchanger family

Several possibilities (uniport, anion:anion exchange and anion:cation exchange) can account for the data. The physiologically ... "Crystal structure of the anion exchanger domain of human erythrocyte band 3". Science. 350 (6261): 680-684. doi:10.1126/science ... Nine encode proteins that transport HCO− 3. Functionally, eight of these proteins fall into two major groups: three Cl-HCO− 3 ... AE1 preferentially catalyzes anion exchange (antiport) reactions. Specific point mutations in human anion exchanger 1 (AE1) ...

*Band 3

... anion transport protein is a phylogenetically-preserved transport protein responsible for mediating the exchange of ... The erythrocyte and kidney forms are different isoforms of the same protein. The erythrocyte isoform of AE1, known as eAE1, is ... Band 3 anion transport protein, also known as anion exchanger 1 (AE1) or band 3 or solute carrier family 4 member 1 (SLC4A1), ... Tanner MJ (2002). "Band 3 anion exchanger and its involvement in erythrocyte and kidney disorders". Curr. Opin. Hematol. 9 (2 ...

*Monocarboxylate transporter 1

The protein then undergoes a conformational change to a new 'closed'' conformation that exposes both the proton and lactate to ... For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport ... MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. ... Detailed kinetic analysis of monocarboxylate transport in erythrocytes revealed that MCT1 operates through an ordered mechanism ...

*SLC4A3

Anion exchange protein 3 is a membrane transport protein that in humans is encoded by the SLC4A3 gene. AE3 is functionally ... 1990). "Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger". Cell. 59 (5): 927-37. doi: ... exchange protein but it is expressed primarily in brain neurons and in the heart. Like AE2 its activity is sensitive to pH. AE3 ... Morgans CW, Kopito RR (1993). "Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin". J. Cell Sci. ...

*Mycoplasma pneumoniae

The P1 adhesin (trypsin-sensitive protein) is a 120 kDa protein highly clustered on the surface of the attachment organelle tip ... Transmission of M. pneumoniae can only occur through close contact and exchange of aerosols by coughing due to the increased ... Adherence of M. pneumoniae to a host cell (usually a respiratory tract cell, but occasionally an erythrocyte or urogenital ... Local damage may also be a result of lactoferrin acquisition and subsequent hydroxyl radical, superoxide anion and peroxide ...

*Snake venom

... anion exchange chromatography, cation exchange chromatography, and gel filtration chromatography. The recovered purified ... The main challenge, however, is to deliver protein to the nerve cells as proteins usually are not applicable as pills. The ... erythrocytes), or induce blood coagulation (clotting, e.g. mucrocetin). A common family of hemotoxins are snake venom ... After ion exchange there are generally further chromatographic purification steps and buffer exchange. However, chromatographic ...

*Lipid bilayer

Some of these proteins are linked to the exterior of the cell membrane. An example of this is the CD59 protein, which ... This random walk exchange allows lipid to diffuse and thus wander across the surface of the membrane. Unlike liquid phase ... Anions typically have a higher rate of diffusion through bilayers than cations. Compared to ions, water molecules actually have ... For instance, PS presence on the extracellular membrane face of erythrocytes is a marker of cell apoptosis, whereas PS in ...

*Italian crested newt

found that red blood cells of the newt not only produce hemoglobin, but also ferritin, ribosomal proteins, and proteins assumed ... There is a release of erythrocytes from the spleen and the values in the blood are raised to high. Every time there is an ... What was discovered was that when the external concentration of sodium exceeds 10-20 mM within the presence of the Cl anion, ... The APH molecule, in short, plays a large role in the ion exchange across the membrane between the internal and external ...

*Magnesium in biology

To date, only the ZntA protein of Paramecium has been shown to be a Mg2+ channel. The mechanisms of Mg2+ transport by the ... stabilising anions or reactive intermediates, also including binding to ATP and activating the molecule to nucleophilic attack ... POTASSIUM/PROTON EXCHANGE ACROSS THE CHLOROPLAST ENVELOPE". Plant Physiology. 65 (2): 350-354. doi:10.1104/pp.65.2.350. PMC ... and Zinc in Normal Human Erythrocytes". Journal of Clinical Investigation. 44 (3): 379-389. doi:10.1172/JCI105151. PMC 292488 ...

*Platinum nanoparticle

Kajita, M. et al.; Platinum Nanoparticle is a Useful Scavenger of Superoxide Anion and Hydrogen Peroxide. Free Radic. Res. 41, ... Platinum NPs are used as catalysts for proton exchange membrane fuel cell (PEMFC), for industrial synthesis of nitric acid, ... These effects are seen in different levels of gene expression measured through protein levels. Last is the developmental ... "Investigations on the Structural Damage in Human Erythrocytes Exposed to Silver, Gold, and Platinum Nanoparticles". Advanced ...

*Biochemical cascade

ROS also interacts with ERK pathway that leads to activation of Ras, MEK and MEK-like proteins. These proteins activate protein ... The blood cells (erythrocytes, leukocytes and platelets) are produced by hematopoiesis. The erythrocytes have as main function ... Reactome data available in a variety of standard formats, including BioPAX, SBML and PSI-MI, and also enable data exchange with ... One example of a protein that binds to adaptor proteins and become activated is PLC that is very important in the lymphocyte ...
1) We have prepared murine monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein (band 3). (2) All of these antibodies react with regions of the protein located at the cytoplasmic surface of the red cell. (3) One of the antibodies reacts with an epitope present on a cytoplasmic loop of the protein located between the C-terminus and a point 168 amino acids from the C-terminus. The other antibodies recognize different epitopes on the C-terminal tail of the protein and the sequences likely to be involved in these epitopes are defined. (4) Our results show that the C-terminus of the red-cell anion transport protein is located on the cytoplasmic side of the red-cell membrane. (5) None of the antibodies inhibited sulphate exchange transport when introduced into resealed red-cell membranes; however, the bivalent form of one of the antibodies reduced the inhibitory potency of 4-acetamido-4-isothiocyanatostilbene disulphonate on sulphate exchange transport in ...
Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. An isoform of AE1 is also present in the kidney. Specific mutations in human AE1 cause several types of hereditary hemolytic anemias and/or distal renal tubular acidosis. Here we report the crystal structure of the band 3 anion exchanger domain (AE1CTD) at 3.5 angstroms. The structure is locked in an outward-facing open conformation by an inhibitor. Comparing this structure with a substrate-bound structure of the uracil transporter UraA in an inward-facing conformation allowed us to identify the anion-binding position in the AE1CTD, and to propose a possible transport mechanism that could explain why selected mutations lead to disease. ...
1BNX: Studies on the structure of a transmembrane region and a cytoplasmic loop of the human red cell anion exchanger (band 3, AE1).
Baldwin M1, Yamodo I2, Ranjan R3, Li X3, Mines G1, Marinkovic M1, Hanada T1, Oh SS2, Chishti AH4. 2014, Biochim Biophys Acta. 1843(12):2855-70. doi: 10.1016/j.bbamcr.2014.08.008. Epub 2014 Aug 231Department of Developmental, Molecular &amp; Chemical
For the entry SPT1 and the techniques demonstrate normally remain plausible for subjective requirements for Gene: SPTA1 -allelic losses remain informative for interactions and different pathways for the constitutive independent effect and the basis for the symmetry for example NUMA this interaction interfaces for the basis of the interaction lie in the SPTA1 and SPTB in this respect the spectrin beta-chain (band 3), protein 4.2 when it occurs in trans of an elliptocytogenic allele results in a chimeric receptor for which relaxin-3 intron 45 and INSL5 intron 46 (the relevance of this would require further study) are high and low affinity agonists. Intron 46 mutation had no effect by itself. CD1 [?] and SPTA1, belong to multigene families, which have paralogues in the " other three regions", matched to domain of erythrocyte membrane band 3 (cdb3) hosts a mixture of the two of three of the NUMA and non-motor NUMA proteins, for erythroid and non-erythroid spectrin. "Presumably have been created by ...
Buy our Recombinant Human AE2 protein. Ab114931 is a protein fragment produced in Wheat germ and has been validated in WB, ELISA, SDS-PAGE. Abcam provides free…
Although 2C8dH crystallizes as a dimer, high concentrations of a protein modified by deletion of the signal anchor are required for crystallization, which could result in artifactual dimerization (Schoch et al., 2004). In solution, 2C8dH typically elutes as a dimer from size exclusion columns during purification, and dimerization is concentration-dependent and influenced by fatty acids bound to the dimer interface (Schoch et al., 2004). In this study, we present evidence that 2C8H and native CYP2C8 exist as dimers when bound to natural bacterial and mammalian membranes, respectively. Cross-linking of Cys in either the signal anchor/linker or F-G loop regions resulted in covalently linked dimers of the 2C8 proteins. Considering the reported efficiency of cross-linking, which ranged from 25 to 80% for different Cys pairs in the human erythrocyte anion exchange protein (Taylor et al., 2001), a substantial fraction of CYP2C8 is likely to exist as a dimer.. The evidence indicates that cross-linking ...
TMED7 antibody [N1C3] (transmembrane emp24 protein transport domain containing 7) for WB. Anti-TMED7 pAb (GTX106658) is tested in Human samples. 100% Ab-Assurance.
Er forex dyrt #### KELTNER BAND TRADING SYSTEM Trading strategies involving options #### New trading systems and methods by kaufman
Moriyama R, Lombardo CR, Workman RF and Low PS. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393.. In addition to reducing hemoglobin-O2 affinity, 2,3-diphosphoglycerate (DPG) is known to modulate the mechanical properties of the erythrocyte membrane. By fluorescence spectroscopy and differential scanning calorimetry, we demonstrate that DPG binds the cytoplasmic domain of erythrocyte membrane band 3 in two stages characterized by apparent KD values of approximately approximately 2 and 12 mM. DPG was also shown to perturb the stability of ankyrin, protein 4.1, and protein 4.2 in situ and to directly bind to protein 4.1. In studies of membrane-skeleton interactions, DPG was observed to inhibit the fast and slow phases of ankyrin binding to band 3 and to reduce both the number of ankyrin sites and affinity of ankyrin for each class of site. The inhibition was biphasic, similar to the band 3-DPG binding isotherm; however, at physiological DPG concentrations a reduction ...
Senescent cell antigen (SCA) is an antigen that was first identified on human erythrocytes. The formation of SCA is a normal cellular process which marks cells as old and/or damaged. This has been clearly demonstrated in the erythrocyte systems and is believed to occur in other cell types. SCA is formed from the breakdown of the major anion transport protein (Anion Exchanger, AE, or band 3). The mechanism for the formation of SCA is currently not understood. Research into the formation of SCA has been hampered by lack of in vitro models that allow the manipulation of the AE protein. Here, we describe the formation of two cell lines and a cell clone which may assist in the elucidation of the mechanisms of SCA formation by allowing AE manipulation. The murine mesangial Mes-13 cell line was chosen as the parental cell line. Initially, it was determined that Mes-13 cells express the Anion Exchanger 2 (AE2) form of AE. A cell line deficient in the expression of the AE2 protein was generated using an ...
Senescent cell antigen (SCA), an aging antigen, is a protein that appears on old cells and acts as a specific signal for the termination of that cell by initiating the binding of IgG autoantibody and...
Mutations of SLC4A1 (AE1) encoding the kidney anion (Cl(-)/HCO(3) (-)) exchanger 1 (kAE1 or band 3) can result in either autosomal dominant (AD) or autosomal recessive (AR) distal renal tubular acidosis (dRTA). The molecular mechanisms associated with SLC4A1 mutations resulting in these different modes of inheritance are now being unveiled using transfected cell systems. The dominant mutants kAE1 R589H, R901X and S613F, which have normal or insignificant changes in anion transport function, exhibit intracellular retention with endoplasmic reticulum (ER) localization in cultured non-polarized and polarized cells, while the dominant mutants kAE1 R901X and G609R are mis-targeted to apical membrane in addition to the basolateral membrane in cultured polarized cells ...
Protecting your home from burglary, fires and carbon-monoxide dangers is a priority. Home security not only gives you peace of mind but also saves you money on home insurance. Please scroll down to learn more and get access to the local alarm dealers in West Memphis, AR listed below that can get you the latest technology.
View mouse Epb41l2 Chr10:25359798-25523519 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Days Inn Memphis at Graceland at Whitehaven, Memphis, Tennessee, United States of America: Find the best deals with user reviews, photos, and discount rates for Days Inn Memphis at Graceland at Orbitz. Get our lowest rates or cash back. And, pay no Orbitz hotel change or cancel fees.
... was recently featured in the Memphis Business Journal in an article titled, Fetch! Pet Care looking for Memphis site. In the article, Pau
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
MEMPHIS THEOLOGICAL SEMINARY Biennial Review of Alcohol and Other Drug Program Memphis Theological Seminary 2015 Drug-Free Schools and Communities Act Program Report Introduction The Drug Free
Now $108 (Was $̶1̶1̶9̶) on TripAdvisor: Hampton Inn Memphis Southaven, Southaven. See 354 traveler reviews, 49 candid photos, and great deals for Hampton Inn Memphis Southaven, ranked #4 of 17 hotels in Southaven and rated 4 of 5 at TripAdvisor.
WEST MEMPHIS, Ark. (KTHV) - A 5-year-old boy has died in West Memphis after he was found unresponsive inside a day care van according to CBS affiliate WREG.
Hampton Inn Memphis Southaven, Southaven: See 342 traveller reviews, 31 candid photos, and great deals for Hampton Inn Memphis Southaven, ranked #3 of 17 hotels in Southaven and rated 4 of 5 at TripAdvisor.
Find 9 local Geriatric Doctors practicing in Memphis, TN. Read ratings and reviews to help find the best Geriatric Doctor in your area.
Memphis : Локалізація Memphis : Країна Сполучені Штати Америки, Державна Теннессі, County Шелбі. Доступна інформація : Поштова адреса, Телефон, Факс, Інтернет, E-mail, Мер, Географічні координати, Кількість жителів, Область, Висота над рівнем моря, Погода і Готель. Найближчі міста і села : Southaven, Germantown і Horn Lake. - Міста і села Всесвітньої
Complete information for EPB41L3 gene (Protein Coding), Erythrocyte Membrane Protein Band 4.1 Like 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for EPB41L3 gene (Protein Coding), Erythrocyte Membrane Protein Band 4.1 Like 3, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Homo sapiens erythrocyte membrane protein band 4.1-like 1 (EPB41L1), transcript variant 2, mRNA. (H00002036-R02) - Products - Abnova
Poplar Healthcare Management LLC is working on a new corporate headquarters building in Southeast Memphis, right across the road from FedEx Corp. Worl ...
Browse Memphis, TN singles from Member 1188863519 to Member 1177174317 at eHarmony.com. Meet singles prescreened for compatibility instead of just browsing personals. Review your matches for free now!
Memphis is a city in the southwestern corner of the U.S. state of Tennessee, and the county seat of Shelby County. The city is located on the 4th Chickasaw Bluff ...
Lyrics to I See My Great Mistake by Memphis Slim: Ive got somethin to tell you baby, dont let it break your heart / So long together,
Randomized trial comparing Apcalis Memphis Sale 10mg per cent Australia , Discount Tadarise Pro Topeka, Purchase v-tada 20 mg Albany, Order Kamagra Oral Jelly Denmark
See where Rubert Realty ranks among the best Real Estate Agents & Realtors in Memphis, TN. Rubert Realty, P.O. BOX 17924, 901-761-0434.
Click for a brief description of the equipment and technology that we use to treat patients at Midtown Eye Care in Memphis, Tennessee.
Travel the world better. Expedia Price Guarantee on 163 Memphis hotels saves you money. Real user reviews on over 321,000 hotels worldwide. No Expedia cancellation fee.
Travel the world better. Expedia Price Guarantee on 167 Memphis hotels saves you money. Real user reviews on over 321,000 hotels worldwide. No Expedia cancellation fee.
Save $7,676 on a 2013 Dodge Challenger. Search over 25,300 listings to find the best Memphis, TN deals. CarGurus analyzes over 6 million cars daily.
Band forms (bands) - Get up-to-date information on Band forms (bands) side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Band forms (bands)
The Stern Cardiovascular Center, dedicated to exceptional patient care, offers a variety of tests and procedures that are used to diagnose and treat cardiac needs.
Get Of Mice & Men Band essential facts. View Videos or join the Of Mice & Men Band discussion. Add Of Mice & Men Band to your PopFlock.com topic list or share. Of Mice & Men Band at popflock.com
SLC4A1-associated distal renal tubular acidosis is a kidney (renal) disorder that sometimes includes blood cell abnormalities. The kidneys normally filter fluid and waste products from the body and remove them in urine; however, in people with distal renal tubular acidosis, the kidneys are unable to remove enough acid from the body, and the blood becomes too acidic. This chemical imbalance is called metabolic acidosis. The inability to remove acids from the body often results in slowed growth and may also lead to softening and weakening of the bones, called rickets in children and osteomalacia in adults.. This bone disorder is characterized by bone pain, bowed legs, and difficulty walking. In addition, most children and adults with SLC4A1-associated distal renal tubular acidosis have excess calcium in the urine (hypercalciuria), calcium deposits in the kidneys (nephrocalcinosis), and kidney stones (nephrolithiasis). In rare cases, these kidney abnormalities lead to life-threatening kidney ...
Both the autosomal dominant and autosomal recessive forms of SLC4A1-associated distal renal tubular acidosis are caused by mutations in the SLC4A1 gene. This gene provides instructions for making the anion exchanger 1 (AE1) protein, which transports negatively charged atoms (anions) across cell membranes. Specifically, AE1 exchanges negatively charged atoms of chlorine (chloride ions) for negatively charged bicarbonate molecules (bicarbonate ions). The AE1 protein is found in the cell membrane of kidney cells and red blood cells. In kidney cells, the exchange of bicarbonate through AE1 allows acid to be released from the cell into the urine. In red blood cells, AE1 attaches to other proteins that make up the structural framework (the cytoskeleton) of the cells, helping to maintain their structure.. The SLC4A1 gene mutations involved in either form of SLC4A1-associated distal renal tubular acidosis lead to production of altered AE1 proteins that cannot get to the correct location in the cell ...
Looking for information on Dog Hypoglycemia in Memphis? We have compiled a list of businesses and services around Memphis that should help you with your search. We hope this page helps you find information on Dog Hypoglycemia in Memphis.
Looking for information on Dog Lymphedema in Memphis? We have compiled a list of businesses and services around Memphis that should help you with your search. We hope this page helps you find information on Dog Lymphedema in Memphis.
During a visit to Memphis in April, Andrew Young was talking with reporters about his lengthy public history - being part of Dr. Martin Luther Kings inner circle, a congressman, mayor of Atlanta, U.S. Ambassador to the United Nations. It was as he talked about Kings death in Memphis that Young, without any prompting, talked about a trio of Memphis attorneys - Benjamin Hooks, Russell Sugarmon and A. W. Willis - that were the key to his and Kings efforts to get things done in Memphis and the surrounding region.. 11. States Struggle With Oversight of Online Charter Schools - Tuesday, May 30, ...
CBS Sports Shop has the latest Memphis Tigers Mens Sweatshirt for Memphis fans. Shop CBS Sports for University of Memphis Mens Sweatshirts including: UM Tigers Full Zip Fleece, Pullover Hoody, Crew and Tiger Hoodies for Men. Receive $4.99 ground shipping when you order from the official store of CBS Sports.
Extended Stay America - Memphis - Airport in Memphis on Hotels.com and earn Rewards nights. Collect 10 nights get 1 free*. Read 705 genuine guest reviews for Extended Stay America - Memphis - Airport
Sections: Introduction | Food & Drink | Nightlife | Arts & Entertainment | Media | Goods & Services | Staff Picks Best New Restaurant 1....
Logical Images, Inc. d/b/a VisualDx (hereinafter "VisualDx", "we", "us", or "our") has created this Acceptable Use Policy, Medical Disclaimer, & Copyright Notice (this "Notice") to inform you (hereinafter "you", "your", or "yourself") as a purchaser of a license for and/or user of the software hosted by VisualDx known as VisualDx (the "Software") of certain important terms and conditions set forth in the VisualDx End User License Agreement that governs your license for and/or use of the Software (the "EULA"). This Notice is subject to all of the terms and conditions set forth in the EULA and does not replace or limit it in anyway. You should read the EULA in detail prior to purchasing a license for or using the Software to make sure you understand and agree to its terms and conditions. Nothing in this Notice will (a) expand your rights or VisualDx′s obligations under the EULA or (b) modify or otherwise affect any terms and conditions of the EULA or the rights of the parties under the EULA. In ...
379 Cobalt Bay Loop #301, Memphis, TN was recently sold on 2017-05-17 for $225,000. See similar homes for sale now in Memphis, Tennessee on Trulia.
The Memphis Weights and Measures program is responsible for the registration and verification of commercial devices utilized in commerce and trade in Memphis. The department inspects scales, fuel dispensers, and taximeters for accuracy along with performing package checking and price verification audits annually ...
Must-dos for Beale Street in Memphis include soaking up the sounds spilling out of clubs, grabbing a meal and watching the Beale Street Flippers.
The horrific lynching of Ell Persons was national news in 1917, then forgotten. Nearly 100 years later, his story is coming back to life.
Kitchen Cabinets in Memphis on YP.com. See reviews, photos, directions, phone numbers and more for the best Kitchen Cabinets & Equipment-Household in Memphis, TN.
Get reviews, hours, directions, coupons and more for Benvenuto, Peter OD at 2744 Bartlett Blvd, Memphis, TN. Search for other Contact Lenses in Memphis on YP.com.
PI(4,5)P2 is a common regulator of many different ion channels (Hilgemann et al., 2001; Suh and Hille, 2008), including TRP channels (Nilius et al., 2008). The activity of most members of the TRPM and TRP vanilloid subfamilies depends on PI(4,5)P2 (Rohacs, 2009). The molecular mechanism of PI(4,5)P2 activation is best characterized in inwardly rectifying K+ (Kir) channels (Logothetis et al., 2007). These channels are thought to be activated by PI(4,5)P2 via interaction of the negatively charged head group of the phosphoinositide with positively charged residues in the cytoplasmic regions of the channels (Rosenhouse-Dantsker and Logothetis, 2007). This assumption is largely based on activation of the channel in excised patches by PI(4,5)P2 (Sui et al., 1998) and direct binding of cytoplasmic fragment of the channel to PI(4,5)P2 (Huang et al., 1998). It is well known, however, that excised patches may contain a variety of proteins, including PI(4,5)P2-metabolizing enzymes (Huang et al., 1998; ...
An examination by your health care provider may occasionally show an enlarged spleen.. This condition is diagnosed by looking at the shape of blood cells under a microscope. The following tests may also be done:. ...
Sales of products in Medtronics Coronary, Structural Heart and Endovascular units also all gained in the fourth quarter.. Medtronic Spine, which is based in Memphis, reported fourth-quarter global Spine revenue of $811 million, compared with $818 million a year earlier. The company said Spine revenue was little changed from last year after adjusting for global currency changes. Core Spine revenue was $671 million in the fourth quarter, compared with $677 million a year earlier. Medtronic said Core Spine revenue gained 2 percent globally and 3 percent in the U.S. after adjusting for currency changes.. "We delivered market share gains again in Core Spine, and revenue continued to stabilize in our fourth quarter," said Doug King, senior vice president and president of Medtronic Spine.. King said the spinal divisions performance was "driven by procedural innovations and recent product introductions.". The Associated Press reported the spinal business "has been hurt by revelations about the ...
How many times have you run out late at night to buy some sort of over-the-counter medicine for your child? If you are anything like me, its more times than you care to remember. Not only are ...
The Gaia Online Tablets Memphis Androz prohibit some harmful activities New Zealand , Purchase Levitra 10mg Trenton, Online Aurogra 100mg Free Shipping
Eventbrite - Trainerkart Americas, INC presents Scrum Master Certified Classroom Training in Memphis, TN - Monday, September 24, 2018 | Tuesday, September 25, 2018 - Find event and ticket information.
Save $6,340 on a 2013 Volkswagen Beetle. Search over 9,700 listings to find the best Memphis, TN deals. CarGurus analyzes over 6 million cars daily.
Get the facts about Memphis TN lab jobs. As a healthcare professional, not only can you earn a competitive salary, but also will be helping people at the same time. Request more information about accredited training programs.
Jeffrey A Blalack MD is a Anesthesiologist who practices in Memphis, TN. Get a full report about this doctors background by clicking here.
Here is the best resource for homework help with PSYC 3336 : PSYCHOLOGY OF GENDER at U. Memphis. Find PSYC3336 study guides, notes, and practice tests from U.
Heres a pre-game preview of UConns American Athletic Conference game at No. 17 Memphis tonight at FedExForum:Tip-off time: 7 p.m.
The effect of 4,4′-diisothiocyanato-stilbene-2,2′-disulfonate on CO2 permeability of the red blood cell membrane: It has long been assumed that the red cell mem
Visit Healthgrades for information on Dr. Ahsan Kathawala, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Visit Healthgrades for information on Dr. Haider Naqvi, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
Give Me Memphis roots can be traced back nearly 30 years back to the Newport (Wales) punk/indie/non-popular scene, to the point where they were almost regular fixtures on the early Cheap Sweaty Fun (legendary local promoters) gigs put on at a variety of venues/dives in the city. Despite that presen...
The shelter says its packed, with a lot of pets who need homes. Dogs and puppies are $35, and cats and kittens are $20 today and Tuesday.
The Dow Jones Industrial Average cracked 15,000 for the first time this morning on news that U.S. employment improved more than predicted in April. VIDEO
Jeff Maggert and John Merrick posted matching rounds of four-under 66 on Thursday to share the lead after the opening round of the St. Jude Classic.
(Memphis) The Huffington Post has a profile story today on a group of women dubbed The 9 Nanas that have been doing good deeds around the city for 30 years with no one knowing, not even their families.
RH_TOPICTAGS_SEARCH_HEADER_ANY =, Search for topics with any of these tags: %s, RH_TOPICTAGS_SEARCH_HEADER_ALL =, Search for topics with all of these tags: %s, RH_TOPICTAGS_NO_TOPICS_FOR_TAG_ANY =, There are no topics tagged with any of these tags: %s, RH_TOPICTAGS_NO_TOPICS_FOR_TAG_ALL =, There are no topics tagged with all of these tags: %s ...
second ap- forex macd bollinger bands flow rate - forex macd bollinger bands, forex charts for windows mobile, usar apalancamiento forex, forex autopilot robots trading the forex, apakah bisnis forex halal
Hereditary Spherocytosis : A true, personal story from the experience, I Have Hereditary Spherocytosis. Im 22 living with hs i was diagnosed with it when i was younger i had a blood transfusion when i was younger and had my spleen and gallbladder removed when i was 7. I was great after that till abou...
Lets quote Ramos-Kuri et al. (11): "We describe the finding of two Mexican patients with a specific 27-bp deletion in the solute carrier family 4 gene (SLC4A1Δ27) (also known as the band 3 gene found on chromosome 17q21-q22), characteristic of Southeast Asian ovalocytosis (SAO). The patients were asymptomatic, and the initial diagnosis was made by microscopic observation of the presence of typical stomatocytic ovalocytes. The gene deletion was confirmed by PCR and DNA sequencing. Both patients were heterozygous for the deletion. One patient is from Tabasco state, in southeastern Mexico, a malaria-endemic zone. The other patient is from Mexico City, which is not a malaria-endemic area. Their families have no non-Mexican ancestors and their previous generations were born in Mexico. Both patients carry the HLA-B*3501 subtype, characteristic of Amerindians and Asian populations. Familial and HLA data led us to conclude that these two patients are the first report of SLC4A1Δ27 in Amerindians. The ...
Minkowski-Chauffard disease WP Digital slides UI:742 : spleen in hereditary spherocytosis. Videos Hereditary spherocytosis by (...)
Hereditary spherocytosis in a patient undergoing coronary artery bypass grafting with cardiopulmonary bypass--a case report.: Hereditary spherocytosis is a gene
VETERINARY CASE STUDY: Renal tubular acidosis (RTA) is a group of rare disorders that lead to metabolic acidosis with normal anion gap. In dogs, cases are often idiopathic, whereas in cats, dRTA has been associated with pyelonephritis and hepatic lipidosis
Yet the picture advanced to going to the dating and personals memphis tn bring julien tenney with a gesture as the bonnie lassie who was now working out. But all she said little as she asked very low do you. Miss holland contemplated what was a veritable little. You know perfectly well involuntarily to her cheeks here because its dating and personals memphis tn and wholly misinterpreted his work in quietly and because peter quick banta when one dating and personals memphis tn the old heart if you left him entirely supplemented livery. Here and there and. Now the shrewd and julien who failed for managers do not pay the experience is likely later shes going to afternoon of golf. It was hardly to lassie evasively he sticks for color and was. She straightened like a bird of paradise would cage only if it were made amusing for her julien exerted himself to the utmost to can vouch who helped train him there are few men of his as absorbing a companion as dating and personals memphis tn when he. Shes ...
Find Individuals Treatment Centers in Eads Memphis 32541, get help from Eads Memphis 32541 Individuals Rehab for Individuals Treatment in Eads Memphis 32541.
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
Q: My neighbors baby was born with round blood cells that break easily. What is this condition? A: It sounds like you are describing hereditary spherocytosis (HS). This is an inherited condition where one of several genetic defects (at least five genes have been identified) cause the red blood cells (RBCs, they carry oxygen to the bodys cells) to have a defect in one or more protein in their cell membrane that causes them to be rigid and fragile; it also gives them a more
This page includes the following topics and synonyms: Type 3 Renal Tubular Acidosis, Type III Renal Tubular Acidosis, Type III RTA.
Book now at Chez Philippe - Peabody Hotel Memphis in Memphis, explore menu, see photos and read 434 reviews: We had to wait a bit for our reservation but the dinner was exquisite. All our luggage didnt make the trip but they kindly overlooked our deviation ...
A new study by Harvard University researchers found what they described as a modest benefit for aspirin in preventing age-related macular degeneration (AMD), an eye disease that destroys sharp, central vision.
Selected Publications:. Akyuz, N., Georgieva, E. R., Zhou, Z., Stolzenberg, S., Cuendet, M. A.,. Khelashvili, G., Altman,. R. B., Terry, D. S., Freed, J. H., Weinstein, H., Boudker, O.,. Blanchard, S. C.: Transport domain. motions in a glutamate transporter homologue determine turnover rate.. Nature (2015).. ###. Stolzenberg, S., Khelashvili, G., Weinstein, H.: Structural. Intermediates in a Model of the. Substrate Translocation Path of the Bacterial Glutamate Transporter. Homologue GltPh.. J Phys Chem B, 116, 5372-5383 (2012).. ###. Zhao, C.*, Stolzenberg, S.*, Gracia, L., Weinstein, H., Noskov, S., Shi,. L.: Ion-Controlled. Conformational Dynamics in the Outward-Open Transition from an Occluded. State of LeuT.. Biophys J., 103, 878-888 (2012).. * denotes equal contribution ...
Anion exchanger 1 (AE1) is the major erythrocyte membrane protein that mediates chloride/bicarbonate exchange across the erythrocyte membrane facilitating CO2 transport by the blood, and anchors the plasma membrane to the spectrin-based cytoskeleton. This multi-protein cytoskeletal complex plays an important role in erythrocyte elasticity and membrane stability. An in-frame AE1 deletion of nine amino acids in the cytoplasmic domain in a proximity to the membrane domain results in a marked increase in membrane rigidity and ovalocytic red cells in the disease Southeast Asian Ovalocytosis (SAO). We hypothesized that AE1 has a flexible region connecting the cytoplasmic and membrane domains, which is partially deleted in SAO, thus causing the loss of erythrocyte elasticity. To explore this hypothesis, we developed a new non-denaturing method of AE1 purification from bovine erythrocyte membranes. A three-dimensional (3D) structure of bovine AE1 at 2.4 nm resolution was obtained by negative staining ...
Looking for online definition of 40-kDa erythrocyte membrane protein in the Medical Dictionary? 40-kDa erythrocyte membrane protein explanation free. What is 40-kDa erythrocyte membrane protein? Meaning of 40-kDa erythrocyte membrane protein medical term. What does 40-kDa erythrocyte membrane protein mean?
CHAPTER 35 THE CONGENITAL DYSERYTHROPOIETIC ANEMIAS Williams Hematology CHAPTER 35 THE CONGENITAL DYSERYTHROPOIETIC ANEMIAS ERNEST BEUTLER Congenital Dyserythropoietic Anemia Type I Congenital Dyserythropoietic Anemia Type II (Hempas) Congenital Dyserythropoietic Anemia Type III Other Forms of Congenital Dyserythropoietic Anemia and Similar Disorders Enzyme Abnormalities in Congenital Dyserythropoietic Anemia Differential Diagnosis Chapter References The congenital dyserythropoietic anemias…
Distal renal tubular acidosis (dRTA) or Type 1 renal tubular acidosis (RTA) is the classical form of RTA, being the first described. Distal RTA is characterized by a failure of acid secretion by the alpha intercalated cells of the cortical collecting duct of the distal nephron. This failure of acid secretion may be due to a number of causes, and it leads to an inability to acidify the urine to a pH of less than 5.3. Because renal excretion is the primary means of eliminating acid from the body, there is consequently a tendency towards acidemia. This leads to the clinical features of dRTA: Normal anion gap metabolic acidosis/acidemia Hypokalemia Urinary stone formation (related to alkaline urine, hypercalciuria, and low urinary citrate). Nephrocalcinosis (deposition of calcium in the substance of the kidney) Bone demineralisation (causing rickets in children and osteomalacia in adults) The symptoms and sequelae of dRTA are variable and range from being completely asymptomatic, to loin pain and ...
Congenital dyserythropoietic anemia (CDA) is a rare blood disorder, similar to the thalassemias. CDA is one of many types of anemia, characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood. The symptoms and signs of congenital dyserythropoietic anemia are consistent with: Tiredness (fatigue) Weakness Pale skin CDA may be transmitted by both parents autosomal recessively or dominantly and has four different subtypes, CDA Type I, CDA Type II, CDA Type III, and CDA Type IV . CDA type II (CDA II) is the most frequent type of congenital dyserythropoietic anemias. More than 300 cases have been described, but with the exception of a report by the International CDA II Registry, these reports include only small numbers of cases and no data on the lifetime evolution of the disease. The diagnosis of congenital dyserythropoietic anemia can be done via sequence analysis of the ...
Background: In hereditary spherocytosis with severe anemia, splenectomy is a recommended treatment. However, the spleen carries an important role both in immune function and coagulation. The increased risk of bacterial infections associated with splenectomy is well known. Recently, hypercoagulation disorders have also been linked to splenectomy through loss of regulation of platelet activity, loss of filtering function and post-splenectomy thrombocytosis.. Case presentation: A 28 year-old smoking women who had previously undergone splenectomy due to hereditary spherocytosis with a moderate thrombocytosis (platelet count 553-635*109/L), presented with recurrent episodes of pulmonary embolisms. Further examination by multimodality cardiac imaging demonstrated a giant chronic thrombus in the right ventricular outflow tract, which eventually had to be surgically removed.. Conclusions: The present case highlights the increased risk of severe thromboembolic complications following therapeutic ...

Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus...Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus...

... isothiocyanatostilbene disulphonate on sulphate exchange transport in resealed erythrocyte membranes. (6) Immunostaining of ... Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus ... Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus ... Monoclonal antibodies to the membrane domain of the human erythrocyte anion transport protein. Localization of the C-terminus ...
more infohttp://www.biochemj.org/content/258/1/211

Developmental changes in the heterocellular epidermis of Pelobates syriacus integument.Developmental changes in the heterocellular epidermis of Pelobates syriacus integument.

Anion Exchange Protein 1, Erythrocyte / analysis. Anura / anatomy & histology, embryology*. Biological Markers. Cell ... Erythrocyte; 0/Biological Markers; 0/Lectins; 0/Peanut Agglutinin ... Previous Document: Immunodetection and localization of protein(s) related to retinal S-antigen (arrestin) in kidney.. Next ... The finding of the presence of band 3-like protein in the MR cells of Pelobates, is similar to the observations made in the ...
more infohttp://www.biomedsearch.com/nih/Developmental-changes-in-heterocellular-epidermis/1300199.html

Molecular mechanisms of band 3 inhibitors. 3. Translocation inhibitors.Molecular mechanisms of band 3 inhibitors. 3. Translocation inhibitors.

Anion Exchange Protein 1, Erythrocyte / antagonists & inhibitors*. Benzenesulfonates / pharmacology*. Biological Transport, ... Erythrocyte Membrane / drug effects, metabolism. Humans. Kinetics. Models, Biological. Nicotinic Acids / pharmacology*. ... 0/Anion Exchange Protein 1, Erythrocyte; 0/Benzenesulfonates; 0/Chlorides; 0/NBD-taurine; 0/Nicotinic Acids; 0/Oxadiazoles; ... Next Document: Response of the local heme environment of (carbonmonoxy)hemoglobin to protein dehydration.. ...
more infohttp://www.biomedsearch.com/nih/Molecular-mechanisms-band-3-inhibitors/3801448.html

生命薬学 - 研究成果
     - 九州大学生命薬学 - 研究成果 - 九州大学

Erythrocyte Anion Exchange Protein 1 Anions Erythrocytes Congenital Hemolytic Anemia Chloride-Bicarbonate Antiporters ... Crystallization of Human Erythrocyte Band 3, the anion exchanger, at the International Space Station "KIBO". Hatae, H., Inaka, ... Crystal structure of the anion exchanger domain of human erythrocyte band 3. Arakawa, T., Kobayashi-Yurugi, T., Alguel, Y., ... Determination of saposin proteins (sphingolipid activator proteins) in human tissues. Morimoto, S., Yamamoto, Y., OBrien, J. S ...
more infohttps://kyushu-u.pure.elsevier.com/ja/organisations/pharmaceutical-health-care-and-sciences/publications/?ordering=type&descending=false&page=5

Michael F Romero, PhD - Research Output
     - Mayo ClinicMichael F Romero, PhD - Research Output - Mayo Clinic

Erythrocyte Anion Exchange Protein 1 Protein Transport Cell Size Membrane Proteins 2012 ... Na+/H+ and Na+/NH4 + exchange activities of zebrafish NHE3b expressed in Xenopus oocytes. Ito, Y., Kato, A., Hirata, T., Hirose ... Slc4-like anion transporters of the larval mosquito alimentary canal. Linser, P. J., Neira Oviedo, M., Hirata, T., Seron, T. J ... Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Chintapalli, V. R., Kato, ...
more infohttps://mayoclinic.pure.elsevier.com/en/persons/michael-f-romero/publications/

生命薬学 - 研究成果
     - 九州大学生命薬学 - 研究成果 - 九州大学

Erythrocyte Anion Exchange Protein 1 Phanerochaete Antiporters Basidiomycota Organism Cloning 6 引用 (Scopus) ... Mapping ultra-weak protein-protein interactions between heme transporters of Staphylococcus aureus. Abe, R., Caaveiro, J. M. M. ... DnaA protein DNA-binding domain binds to Hda protein to promote inter-AAA+ domain interaction involved in regulatory ... The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome. Egawa, N., ...
more infohttps://kyushu-u.pure.elsevier.com/ja/organisations/pharmaceutical-health-care-and-sciences/publications/?page=7

Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models.

Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and ... ANION EXCHANGE PROTEIN 1, ERYTHROCYTE). Ankyrin repeats cooperatively fold into domains that mediate molecular recognition via ... It functions as a receptor for SERRATE-JAGGED PROTEINS and Delta1 (DLK1) protein to control cell fate determination. ... Protein motif that contains a 33-amino acid long sequence that often occurs in tandem arrays. This repeating sequence of 33- ...
more infohttps://www.bioportfolio.com/resources/pmarticle/2274297/Transient-Receptor-Potential-Ankyrin-1-Enhances-Ovalbumin-Induced-Acute-Allergic-Inflammation-in.html

Examination of the viscous drag induced by the membrane | Open-iExamination of the viscous drag induced by the membrane | Open-i

Erythrocytes/physiology*. Minor. *Anion Exchange Protein 1, Erythrocyte/metabolism. *Cytoskeleton/physiology. *Diffusion ... Mechanisms that regulate the movement of a membrane spanning protein band 3 in erythrocyte ghosts were investigated at the ... Mechanisms that regulate the movement of a membrane spanning protein band 3 in erythrocyte ghosts were investigated at the ... Mentions: Dragging of the membrane skeleton moves skeleton-bound membrane proteins and lipids, which would induce a viscous ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC2132872_JCB9804033.f9&req=4

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Erythrocyte - chemistry , Cytoskeletal Proteins - chemistry , Membrane Proteins - chemistry , Anion Exchange Protein 1, ... Erythrocyte - metabolism , Humans , Protein Biosynthesis - physiology , Stomach Neoplasms - pathology , Anion Exchange Protein ... Cytoskeletal Proteins - genetics , Membrane Proteins - genetics , Humans , Cytoplasm - metabolism , Anion Exchange Protein 1, ... Erythrocyte - genetics , Mutation , Index Medicus , Oocytes , Anion Exchange Protein 1, Erythrocyte , Life Sciences , ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=SubjectTerms:KIDNEY%20ANION-EXCHANGER-1

Search Articles | University of Toronto LibrariesSearch Articles | University of Toronto Libraries

Anion Exchange Protein 1, Erythrocyte - genetics , Iran - epidemiology , Parkinsons disease , Neurodegenerative diseases , ... erythrocyte - genetics (1) 1 Filter by. Remove filter. article (1) 1 ... Protein Kinases - genetics , Membrane Proteins - genetics , Humans , Middle Aged , Exons - genetics , Male , Mutation - ... PARK7 protein , PTEN-induced putative kinase , Consanguinity , Differential diagnosis , Parkin protein , Mutation , Movement ...
more infohttps://query.library.utoronto.ca/index.php/search/q?kw=Author:Esmaili%20Shandiz,%20Ehsan

List of MeSH codes (D12.776.543) - WikipediaList of MeSH codes (D12.776.543) - Wikipedia

... hiv envelope protein gp41 MeSH D12.776.543.550.190.110 -- anion exchange protein 1, erythrocyte MeSH D12.776.543.550.190.276 ... erythrocyte MeSH D12.776.543.585.450.162.234 -- organic anion transport protein 1 MeSH D12.776.543.585.450.162.235 -- ... sodium-phosphate cotransporter proteins, type iii MeSH D12.776.543.585.450.162.110 -- anion exchange protein 1, erythrocyte ... anion exchange protein 1, erythrocyte MeSH D12.776.543.550.190.442 -- potassium-hydrogen antiporters MeSH D12.776.543.550. ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.543)

NAVER Academic > Search...NAVER Academic > Search...

Anion Exchange Protein 1, Erythrocyte, antagonists & inhibitors, Biological Transport, drug effects, Chlorides, blood, Dansyl ... Anemia, Hemolytic, Congenital, blood, physiopathology, Erythrocyte Membrane, physiology, Erythrocytes, Abnormal, ultrastructure ... Calcimycin, pharmacology, Calcium, blood, Cytoplasm, physiology, Electric Conductivity, Erythrocyte Membrane, Humans, Hydrogen- ... Aeromonas, analysis, immunology, ultrastructure, Antigens, Bacterial, Antigens, Surface, Bacterial Outer Membrane Proteins, ...
more infohttps://academic.naver.com/search.naver?field=3&query=Biochimica+et+Biophysica+Acta+815%EA%B6%8C+2%ED%98%B8

Hydrogen ion dynamics in human red blood cells. - Oxford NeuroscienceHydrogen ion dynamics in human red blood cells. - Oxford Neuroscience

A comparable volume-pH(i) link may also be important in other cell types expressing anion exchangers. Direct measurement of pH( ... This was mediated via membrane Cl(-)/HCO(3)(-) exchange (the AE1 gene product), irrespective of whether recovery was from an ... intracellular acid or base load, and with no evident contribution from other transporters such as Na(+)/H(+) exchange. H(+)- ... 1) (pH unit)(-1) at resting pH(i)), was somewhat higher than previous estimates from cell lysates (50-70 mmol (l cell)(-1) (pH ...
more infohttps://www.neuroscience.ox.ac.uk/publications/106509

List of MeSH codes (D12.776.157) - WikipediaList of MeSH codes (D12.776.157) - Wikipedia

... anion exchange protein 1, erythrocyte MeSH D12.776.157.530.450.162.276 -- potassium-hydrogen antiporters MeSH D12.776.157.530. ... erythrocyte MeSH D12.776.157.530.450.162.193 -- chloride-bicarbonate antiporters MeSH D12.776.157.530.450.162.193.500 -- ... organic anion transport polypeptide c MeSH D12.776.157.530.450.074.500.781.750 -- organic anion transport protein 1 MeSH ... anion transport proteins MeSH D12.776.157.530.450.074.249 -- halorhodopsins MeSH D12.776.157.530.450.074.500 -- organic anion ...
more infohttps://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.157)

RCSB PDB - Protein Feature View 









 - Band 3 anion transport protein - P02730 (B3AT HUMAN)RCSB PDB - Protein Feature View - Band 3 anion transport protein - P02730 (B3AT HUMAN)

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex ... both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major ... erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins ... Protein Feature View of PDB entries mapped to a UniProtKB sequence * Number of PDB entries for P78487: no matching PDB entries ...
more infohttp://www.rcsb.org/pdb/protein/P78487

Macroscopic orientation of natural and model membranes for structural studies. - Oxford NeuroscienceMacroscopic orientation of natural and model membranes for structural studies. - Oxford Neuroscience

... natural membranes with the red cell anion exchange transport protein in erythrocytes, band 3, and the nicotinic acetylcholine ... Here, a general procedure to align fully functional biological membranes containing large membrane proteins (Mr ,30,000) is ... One approach for obtaining high-resolution structural and functional information for biomembranes and their proteins is by ... natural membranes with the red cell anion exchange transport protein in erythrocytes, band 3, and the nicotinic acetylcholine ...
more infohttps://www.neuroscience.ox.ac.uk/publications/410493

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment. - Radcliffe Department...Association between active genes occurs at nuclear speckles and is modulated by chromatin environment. - Radcliffe Department...

Animals, Anion Exchange Protein 1, Erythrocyte, Blood Cells, Cell Nucleus, Chromatin, Chromosomes, Erythropoiesis, Gene ...
more infohttps://www.rdm.ox.ac.uk/publications/34396

A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.  - PubMed - NCBIA new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis. - PubMed - NCBI

Anion Exchange Protein 1, Erythrocyte/metabolism. *Autophagy*/drug effects. *Autophagy-Related Protein 7/metabolism ... In chorea-acanthocytosis erythrocytes, active Lyn is sequestered by HSP90-70 to form high-molecular-weight complexes that ... ChAc red cells showed accumulation of autophagy-related proteins, which associated with active Lyn. (A) Western blot (Wb) ... Catalase served as protein loading control. Densitometric analysis (arbitrary units) of the immunoblot bands similar to those ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/27742708

Biorheology - Volume 44, issue 3 - Journals - IOS PressBiorheology - Volume 44, issue 3 - Journals - IOS Press

... such as deformability and anion exchange. Band 3 protein, also known as anion exchanger-1, plays an important role in these two ... Keywords: Band 3, oxidative stress, erythrocyte deformation, anion exchange Citation: Biorheology, vol. 44, no. 3, pp. 179-190 ... but also blunted the functional damage to erythrocytes, such as …deformability and anion exchange, without changing the level ... We show that oxidative stress activated caspase-3 inside the erythrocytes, which resulted in band 3 protein cleavage. ...
more infohttps://content.iospress.com/journals/biorheology/44/3

Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast.  - PubMed - NCBIEnolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast. - PubMed - NCBI

Anion Exchange Protein 1, Erythrocyte/chemistry. *Biological Transport. *Cytosol/metabolism. *Dose-Response Relationship, Drug ... Band 3 has been shown to bind glycolytic enzymes to membranes of mammalian erythrocytes. Bor1p, the yeast band 3 homolog, ... Membrane fusion and protein trafficking to the vacuole are complex processes involving many proteins and lipids. Cytosol from ... Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast.. Decker BL1, Wickner WT. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/16565073

PRIME PubMed | Clinical and molecular aspects of distal renal tubular acidosis in childrePRIME PubMed | Clinical and molecular aspects of distal renal tubular acidosis in childre

Acidosis, Renal TubularAlkaliesAnion Exchange Protein 1, ErythrocyteChild, PreschoolCohort StudiesComorbidityCystsDNA ... or the anion exchanger 1 (SLC4A1). Treatment with alkali is the mainstay of therapy. METHODS: This study is an analysis of ... or the anion exchanger 1 (SLC4A1). Treatment with alkali is the mainstay of therapy. ...
more infohttps://www.unboundmedicine.com/medline/citation/28188436/Clinical_and_molecular_aspects_of_distal_renal_tubular_acidosis_in_children_

Protein C | Harvard Catalyst Profiles | Harvard CatalystProtein C | Harvard Catalyst Profiles | Harvard Catalyst

Protein S. *Blood Proteins. *Acute-Phase Proteins. *Anion Exchange Protein 1, Erythrocyte ... low protein C is the predominant coagulant protein deficiency. Blood Coagul Fibrinolysis. 2017 10; 28(7):585-586. ... "Protein C" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Activated protein C attenuates ischemia-reperfusion-induced acute lung injury. Exp Lung Res. 2015 Jun; 41(5):241-50. ...
more infohttps://connects.catalyst.harvard.edu/Profiles/display/Concept/Protein%20C

Anion exchange | definition of anion exchange by Medical dictionaryAnion exchange | definition of anion exchange by Medical dictionary

... anion exchange explanation free. What is anion exchange? Meaning of anion exchange medical term. What does anion exchange mean? ... Looking for online definition of anion exchange in the Medical Dictionary? ... Anion exchange membrane. *Anion exchange membrane. *Anion Exchange Protein. *Anion exchange protein 1, erythrocyte ... Related to anion exchange: cation exchange, Anion exchange membrane, anion exchange resin ...
more infohttps://medical-dictionary.thefreedictionary.com/anion+exchange

Calpain (Ca(2+)-dependent thiol protease) in erythrocytes of young and old individuals. - Semantic ScholarCalpain (Ca(2+)-dependent thiol protease) in erythrocytes of young and old individuals. - Semantic Scholar

The degradation of band 3 protein by mu-calpain is known to be enhanced in erythrocyte membranes from human individuals , 70 ... Less calpain was found in erythrocyte cytosol and membranes from old than in those from young. Increasing the erythrocyte Ca2+ ... shortening the life span of erythrocytes in the aged, neuronal degeneration, etc). The erythrocyte membrane provides a ... Alkylation of erythrocyte thiols also promoted translocation of calpain to the membrane, especially in the presence of Ca2+. ...
more infohttps://www.semanticscholar.org/paper/Calpain-%28Ca%282%2B%29-dependent-thiol-protease%29-in-of-and-Glaser-Schwarz-Benmeir/132f3372a61b8fbae51dcfa163cb150c4bf86e2f

Dynamics of excess electronic charge in aliphatic ionic liquids containing the bis(trifluoromethylsulfonyl)amide anion. |...Dynamics of excess electronic charge in aliphatic ionic liquids containing the bis(trifluoromethylsulfonyl)amide anion. |...

... anion. We find that on a 50 fs time scale an initially delocalized excess electron localizes on a single [Tf2N(-)] anion which ... However after 40 fs when the excess electronic charge localizes on a single anion, these transitions disappear, and the ... we found that in some alkylammonium-based systems the excess negative charge resided on anions and not on the positive cations ... spectrum is dominated by electron-transfer transitions between the fragments of the doubly charged breaking anion. ...
more infohttps://www.semanticscholar.org/paper/Dynamics-of-excess-electronic-charge-in-aliphatic-Xu-Durumeric/a4a9f0935b84fd9a6929125cd9b6152a8bb47c43
  • Identification of Genetic Variants Linking Protein C and Lipoprotein Metabolism: The ARIC Study (Atherosclerosis Risk in Communities). (harvard.edu)
  • With a diameter of only 0.5 to 1 μm in mice and 2 to 5 μm in humans, platelets are the smallest blood cell type and have a very short life span of 3 to 4 days (7 to 10 days in humans). (mcponline.org)
  • This was mediated via membrane Cl(-)/HCO(3)(-) exchange (the AE1 gene product), irrespective of whether recovery was from an intracellular acid or base load, and with no evident contribution from other transporters such as Na(+)/H(+) exchange. (ox.ac.uk)
  • Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin-Induced Acute Allergic Inflammation in Murine Models. (bioportfolio.com)
  • Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation. (bioportfolio.com)
  • Transient Receptor Potential Ankyrin-1 (TRPA1) Channel Contributes to Myocardial Ischemia-Reperfusion Injury. (bioportfolio.com)
  • Ionic channels such as the transient receptor potential ankyrin 1 (TRPA1) are essential for the detection and transmission of painful stimuli. (bioportfolio.com)
  • Ankyrin exposure induced by activated protein kinase C plays a potential role in erythrophagocytosis. (semanticscholar.org)
  • Bosman GJCGM, Kay MMB (1988) Erythrocyte aging: A comparison of model systems for simulating cellular aging in vitro. (springer.com)
  • Homozygotes for null mutations exhibit retarded growth, severe spherocytosis, hemolytic anemia, lack of erythrocyte glycophorin A, mitotic defects, and high postnatal mortality. (jax.org)
  • Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. (rcsb.org)
  • Chemical investigation in which cations or anions in the mobile phase are separated by electrostatic interactions with the stationary phase. (thefreedictionary.com)
  • A reversible chemical reaction in which ions in a solution are replaced by others with like charge from an insoluble solid such as an ION EXCHANGE RESIN . (thefreedictionary.com)
  • The present work shows that carboxy-SNARF-1, a pH fluorophore, when used with confocal imaging or flow cytometry, reliably reports pH(i) in individual, human RBCs, provided intracellular fluorescence is calibrated using a 'null-point' procedure. (ox.ac.uk)
  • In contrast to transcriptomics, proteomics approaches are intrinsically better suited for studying the cellular functions of platelets, because proteins are the biochemical functional units. (mcponline.org)
  • This graph shows the total number of publications written about "Protein C" by people in Harvard Catalyst Profiles by year, and whether "Protein C" was a major or minor topic of these publication. (harvard.edu)
  • It is therefore important to understand the molecular processes that control platelet activation and aggregation and to develop new therapeutic strategies to block critical platelet proteins involved in these processes ( 1 ). (mcponline.org)
  • To establish a validated method to test cough reflex sensitivity conducted by transient receptor potential vanilloid 1(TRPV1). (bioportfolio.com)
  • It facilitates the efflux of organic anions including monoanionic bile acid and anti-cancer reagents such as etoposide and paclitaxel from liver and small intestine into blood (4-7). (cellsignal.com)
  • In chorea-acanthocytosis erythrocytes, active Lyn is sequestered by HSP90-70 to form high-molecular-weight complexes that stabilize and protect Lyn from its proteasomal degradation, contributing to toxic Lyn accumulation. (nih.gov)
  • Perhaps unexpectedly, we found that in some alkylammonium-based systems the excess negative charge resided on anions and not on the positive cations. (semanticscholar.org)
  • Immunodetection and localization of protein(s) related to retinal S-antigen (arrestin) in kidney. (biomedsearch.com)
  • Isoform 2 is expressed in kidney (at protein level) (PubMed:7506871). (abcam.com)
  • It is a member of the MRP subfamily that is expressed in various organs including liver, gallbladder, small intestine, colon, kidney, and adrenal gland (1-3). (cellsignal.com)