Salmon: Fish of the genera ONCORHYNCHUS and Salmo in the family SALMONIDAE. They are anadromous game fish, frequenting the coastal waters of both the North Atlantic and Pacific. They are known for their gameness as a sport fish and for the quality of their flesh as a table fish. (Webster, 3d ed).Salmo salar: A commercially important species of SALMON in the family SALMONIDAE, order SALMONIFORMES, which occurs in the North Atlantic.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Fish Diseases: Diseases of freshwater, marine, hatchery or aquarium fish. This term includes diseases of both teleosts (true fish) and elasmobranchs (sharks, rays and skates).Fishes: A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.Food: Any substances taken in by the body that provide nourishment.Aquaculture: Cultivation of natural faunal resources of water. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Ethics, Institutional: The moral and ethical obligations or responsibilities of institutions.Food, Genetically Modified: Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).Human Experimentation: The use of humans as investigational subjects.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Ethics Committees, Research: Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.Attention: Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.Resilience, Psychological: The human ability to adapt in the face of tragedy, trauma, adversity, hardship, and ongoing significant life stressors.Melopsittacus: A genus, commonly called budgerigars, in the family PSITTACIDAE. In the United States they are considered one of the five species of PARAKEETS.Drug Discovery: The process of finding chemicals for potential therapeutic use.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Immune System: The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Tuberculosis, Bovine: An infection of cattle caused by MYCOBACTERIUM BOVIS. It is transmissible to man and other animals.China: A country spanning from central Asia to the Pacific Ocean.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Cattle Diseases: Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.Tuberculosis Vaccines: Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.Tuberculosis: Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM.Pandemics: Epidemics of infectious disease that have spread to many countries, often more than one continent, and usually affecting a large number of people.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Chymosin: The predominant milk-clotting enzyme from the true stomach or abomasum of the suckling calf. It is secreted as an inactive precursor called prorennin and converted in the acid environment of the stomach to the active enzyme. EC 3.4.23.4.Cheese: A nutritious food consisting primarily of the curd or the semisolid substance formed when milk coagulates.Enzymes: Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.Breeding: The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.Food Supply: The production and movement of food items from point of origin to use or consumption.Tissue Plasminogen Activator: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.Plasminogen Activators: A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation.Hepatic Veno-Occlusive Disease: Liver disease that is caused by injuries to the ENDOTHELIAL CELLS of the vessels and subendothelial EDEMA, but not by THROMBOSIS. Extracellular matrix, rich in FIBRONECTINS, is usually deposited around the HEPATIC VEINS leading to venous outflow occlusion and sinusoidal obstruction.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Body Modification, Non-Therapeutic: The wounding of the body or body parts by branding, cutting, piercing (BODY PIERCING), or TATTOOING as a cultural practice or expression of creativity or identity.Transgenes: Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.Genetic Engineering: Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.European Union: The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.United StatesEthics Consultation: Services provided by an individual ethicist (ETHICISTS) or an ethics team or committee (ETHICS COMMITTEES, CLINICAL) to address the ethical issues involved in a specific clinical case. The central purpose is to improve the process and outcomes of patients' care by helping to identify, analyze, and resolve ethical problems.Referral and Consultation: The practice of sending a patient to another program or practitioner for services or advice which the referring source is not prepared to provide.Food Safety: Activities involved in ensuring the safety of FOOD including avoidance of bacterial and other contamination.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.Hydrobiology: The study of aquatic life inhabiting bodies of water, including growth, morphology, physiology, genetics, distribution, and interactions with other organisms and the environment. It includes MARINE HYDROBIOLOGY.

Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient. (1/8283)

Early developmental patterning of the Drosophila embryo is driven by the activities of a diverse set of maternally and zygotically derived transcription factors, including repressors encoded by gap genes such as Kruppel, knirps, giant and the mesoderm-specific snail. The mechanism of repression by gap transcription factors is not well understood at a molecular level. Initial characterization of these transcription factors suggests that they act as short-range repressors, interfering with the activity of enhancer or promoter elements 50 to 100 bp away. To better understand the molecular mechanism of short-range repression, we have investigated the properties of the Giant gap protein. We tested the ability of endogenous Giant to repress when bound close to the transcriptional initiation site and found that Giant effectively represses a heterologous promoter when binding sites are located at -55 bp with respect to the start of transcription. Consistent with its role as a short-range repressor, as the binding sites are moved to more distal locations, repression is diminished. Rather than exhibiting a sharp 'step-function' drop-off in activity, however, repression is progressively restricted to areas of highest Giant concentration. Less than a two-fold difference in Giant protein concentration is sufficient to determine a change in transcriptional status of a target gene. This effect demonstrates that Giant protein gradients can be differentially interpreted by target promoters, depending on the exact location of the Giant binding sites within the gene. Thus, in addition to binding site affinity and number, cis element positioning within a promoter can affect the response of a gene to a repressor gradient. We also demonstrate that a chimeric Gal4-Giant protein lacking the basic/zipper domain can specifically repress reporter genes, suggesting that the Giant effector domain is an autonomous repression domain.  (+info)

A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos. (2/8283)

Surprisingly small peptide motifs can confer critical biological functions. One example is the WRPW tetrapeptide present in the Hairy family of transcriptional repressors, which mediates recruitment of the Groucho (Gro) corepressor to target promoters. We recently showed that Engrailed (En) is another repressor that requires association with Gro for its function. En lacks a WRPW motif; instead, it contains another short conserved sequence, the En homology region 1 (eh1)/GEH motif, that is likely to play a role in tethering Gro to the promoter. Here, we characterize a repressor domain from the Goosecoid (Gsc) developmental regulator that includes an eh1/GEH-like motif. We demonstrate that this domain (GscR) mediates efficient repression in Drosophila blastoderm embryos and that repression by GscR requires Gro function. GscR and Gro interact in vitro, and the eh1/GEH motif is necessary and sufficient for the interaction and for in vivo repression. Because WRPW- and eh1/GEH-like motifs are present in different proteins and in many organisms, the results suggest that interactions between short peptides and Gro represent a widespread mechanism of repression. Finally, we investigate whether Gro is part of a stable multiprotein complex in the nucleus. Our results indicate that Gro does not form stable associations with other proteins but that it may be able to assemble into homomultimeric complexes.  (+info)

Inhibition of doxorubicin toxicity in cultured neonatal mouse cardiomyocytes with elevated metallothionein levels. (3/8283)

Controversial results have been reported regarding whether metallothionein (MT) functions in doxorubicin (DOX) detoxification in the heart. To determine unequivocally the role of MT in cardiac protection against the toxicity of DOX, ventricular cardiomyocytes isolated from 1- to 3-day neonatal transgenic mice with high levels of cardiac MT and from nontransgenic control animals were applied. On the 6th day of culturing, MT concentrations in the transgenic cardiomyocytes were about 2-fold higher than those in the nontransgenic cells. DOX was added directly into the cultures. Compared with nontransgenic controls, transgenic cardiomyocytes displayed a significant (p <.05) resistance to DOX cytotoxicity, as measured by morphological alterations, cell viability, and lactate dehydrogenase leakage from the cells. This cytoprotective effect of MT correlated with its inhibition of DOX-induced lipid peroxidation. These observations demonstrate unequivocally that elevation of MT concentrations in the cardiomyocytes of 2-fold higher than normal provides efficient protection against DOX toxicity.  (+info)

Human nerve growth factor beta (hNGF-beta): mammary gland specific expression and production in transgenic rabbits. (4/8283)

Transgenic rabbits carrying gene constructs encoding human nerve growth factor beta (hNGF-beta) cDNA were generated. Expression of hNGF-beta mRNA was restricted to the mammary gland of lactating rabbits. Western Blot analysis revealed a polypeptide of 13.2 kDa in the milk of transgenic animals. hNGF-beta was purified from the milk by a two-step chromatographic procedure. Electrospray mass spectroscopy analysis of purified hNGF-beta depicted a molecular weight of 13,261 Da per subunit. The biological activity of the hNGF-beta was tested using PC12W2 cells and cultures of dorsal root ganglion neurons from chicken embryos. Crude defatted milk from transgenic animals and purified hNGF-beta demonstrated full biological activity when compared to commercial recombinant hNGF-beta.  (+info)

Aging-specific expression of Drosophila hsp22. (5/8283)

hsp22 is among the least abundantly expressed Drosophila heat shock (hs) genes during both development and heat stress. In contrast, hsp22 was found to be the most abundantly expressed hs gene during Drosophila aging. During aging, hsp22 RNA was induced 60-fold in the head, with somewhat lower level induction in abdomen and thorax. Induction of the other hs gene RNAs was 150-fold, with particularly abundant expression in eye tissue. Aging-specific induction of hsp22 was reproduced by hsp22:lacZ fusion reporter constructs in transgenic flies. Analysis of specific promoter mutations in transgenic flies indicated that functional heat shock response elements are required for hsp22 induction during aging. Finally, comparison of hsp22 RNA and protein expression patterns suggests that aging-specific expression of hsp22 is regulated at both the transcriptional and the posttranscriptional levels. Aging-specific induction of hsp22 is discussed with regard to current evolutionary theories of aging.  (+info)

Transgenic rabbits as models for atherosclerosis research. (6/8283)

Several characteristics of the rabbit make it an excellent model for the study of lipoprotein metabolism and atherosclerosis. New Zealand White (NZW) rabbits have low plasma total cholesterol concentrations, high cholesteryl ester transfer protein activity, low hepatic lipase (HL) activity, and lack an analogue of human apolipoprotein (apo) A-II, providing a unique system in which to assess the effects of human transgenes on plasma lipoproteins and atherosclerosis susceptibility. Additionally, rabbit models of human lipoprotein disorders, such as the Watanabe Heritable Hyperlipidemic (WHHL) and St. Thomas' Hospital strains, models of familial hypercholesterolemia and familial combined hyperlipidemia, respectively, allow for the assessment of candidate genes for potential use in the treatment of dyslipoproteinemic patients. To date, transgenes for human apo(a), apoA-I, apoB, apoE2, apoE3, HL, and lecithin:cholesterol acyltransferase (LCAT), as well as for rabbit apolipoprotein B mRNA-editing enzyme catalytic poly-peptide 1 (APOBEC-1), have been expressed in NZW rabbits, whereas only those for human apoA-I and LCAT have been introduced into the WHHL background. All of these transgenes have been shown to have significant effects on plasma lipoprotein concentrations. In both NZW and WHHL rabbits, human apoA-I expression was associated with a significant reduction in the extent of aortic atherosclerosis, which was similarly the case for LCAT in rabbits having at least one functional LDL receptor allele. Conversely, expression of apoE2 in NZW rabbits caused increased susceptibility to atherosclerosis. These studies provide new insights into the mechanisms responsible for the development of atherosclerosis, emphasizing the strength of the rabbit model in cardiovascular disease research.  (+info)

Production of donor-derived offspring by transfer of primordial germ cells in Japanese quail. (7/8283)

We transfused concentrated primordial germ cells (PGCs) of the black strain (D: homozygous for the autosomal incomplete dominant gene, D) of quail into the embryos of the wild-type plumage strain (WP: d+/d+) of quail. The recipient quail were raised until sexual maturity and a progeny test of the putative germline chimeras was performed to examine the donor gamete-derived offspring (D/d+). Thirty-one percent (36/115) of the transfused quail hatched and 21 (13 females and 8 males) of them reached maturity. Five females and 2 males were germline chimeras producing donor gamete-derived offspring. Transmission rates of the donor derived gametes in the chimeric females and males were 1.8-8.3% and 2.6-63.0%, respectively. Germline chimeric and the other putative chimeric males were also test-mated with females from the sex-linked imperfect albino strain (AL: d+/d+, al/W, where al indicates the sex-linked imperfect albino gene on the Z chromosome, and W indicates the W chromosome) for autosexing of W-bearing spermatozoa: No albino offspring were born.  (+info)

The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons. (8/8283)

We describe here the functional analysis of the C. elegans LIM homeobox gene lim-6, the ortholog of the mammalian Lmx-1a and b genes that regulate limb, CNS, kidney and eye development. lim-6 is expressed in a small number of sensory-, inter- and motorneurons, in epithelial cells of the uterus and in the excretory system. Loss of lim-6 function affects late events in the differentiation of two classes of GABAergic motorneurons which control rhythmic enteric muscle contraction. lim-6 is required to specify the correct axon morphology of these neurons and also regulates expression of glutamic acid decarboxylase, the rate limiting enzyme of GABA synthesis in these neurons. Moreover, lim-6 gene activity and GABA signaling regulate neuroendocrine outputs of the nervous system. In the chemosensory system lim-6 regulates the asymmetric expression of a probable chemosensory receptor. lim-6 is also required in epithelial cells for uterine morphogenesis. We compare the function of lim-6 to those of other LIM homeobox genes in C. elegans and suggest that LIM homeobox genes share the common theme of controlling terminal neural differentiation steps that when disrupted lead to specific neuroanatomical and neural function defects.  (+info)

Vol 9: Zebrafish Transgenic Line huORFZ Is an Effective Living Bioindicator for Detecting Environmental Toxicants.. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the krasV12 oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation between zebrafish and human liver tumorigenesis, the low tumor incidence and early mortality limit its use for further studies of tumor progression and inhibition. Here, we employed a mifepristone-inducible transgenic system to achieve inducible krasV12 expression in the liver. The system consisted of two transgenic lines: the liver-driver line had a liver-specific fabp10 promoter to produce the LexPR chimeric transactivator, and the Ras-effector line contained a LexA-binding site to control EGFP-krasV12 expression. In double-transgenic zebrafish (driver-effector) embryos and adults, we demonstrated mifepristone-inducible EGFP-krasV12 expression in the liver. Robust and homogeneous liver tumors developed in 100% ...
View Notes - Week One from ANTH 2020 at Colorado. of their lives Fight Against Death Donor Transplants Transgenic Pigs • (hyper)Acute Immune Response Fetal Tissues • Blastocyst • Totipotent
TT-RIIP International Course, TRANSGENIC TECHNOLOGIES in MODELING HUMAN DISEASES: Principles, Associated Technologies, Animal Management and Ethics, 5-13 June 2017, Athens, ...
Alex Palazzo has a little post on the "brainbow mouse", created using some of the transgenic methods mentioned by amenestic in a post a while back. Each individual neuron in a given mouse brain expresses a random combination of fluorescent proteins, allowing analysis with the naked eye. Pretty amazing stuff ...
P-glycoproteins can cause multidrug resistance in mammalian tumor cells by active extrusion of cytotoxic drugs. The natural function of these evolutionarily conserved, membrane-bound ATP binding transport proteins is unknown. In mammals, P-glycoproteins are abundantly present in organs associated with the digestive tract. We have studied the tissue-specific expression of Caenorhabditis elegans P-glycoprotein genes pgp-1 and pgp-3 by transformation of nematodes with pgp-lacZ gene fusion constructs in which the promoter area of the pgp genes was fused to the coding region of lacZ. Expression of pgp-1 and pgp-3, as inferred from pgp-lacZ transgenic nematodes, was confined to the intestinal cells. The expression patterns of both genes were virtually indistinguishable. Quantitative analysis of pgp mRNA levels during development showed that pgp-1, -2, and -3 were expressed throughout the life cycle of C.elegans, albeit with some variation indicating developmental regulation. The expression of P-glycoprotein
Claudin 5 as a prominent TJ protein is a consistent feature between the BBB and blood-CSF barrier (Bill and Korzh, 2014). Here we have used this feature to create an in vivo model for real-time analysis of the development, structure and function of the BBB and CP by generating a transgenic zebrafish line that expresses EGFP under the claudin 5a promoter. The high homology and synteny with human, the conservation along the teleost lineage and the previous characterisation of Claudin 5a in zebrafish makes cldn5a a logical candidate (Abdelilah-Seyfried, 2010; Xie et al., 2010; Zhang et al., 2012).. We show that developmental expression of cldn5a:EGFP is restricted to, and starts in both CPs and the midline at 1 dpf, thereby narrowing down the previously shown whole-mount in situ hybridizations (Zhang et al., 2010). The presence of Claudin 5a at the CPs at 1 dpf coincides with the inflation of the ventricles (Zhang et al., 2010, 2012) and corroborates its role in this process. Claudin 5a is crucial ...
Cell cycle analysis of transgenic zebrafish embryos expressing PCNA-CB. (A) Overview of the dorsal midbrain of a wnt1:gal4,UAS:GFP (green); UAS:PCNA-CB (magenta
BioAssay record AID 620365 submitted by ChEMBL: Antiangiogenic activity in fli-1:enhanced GFP expressing transgenic zebrafish embryo assessed as inhibition of neovacularisation at 5 uM after 24 hrs relative to control.
The study is the first to document the rise of mutations that make mosquitoes resistant to a gene drive, due to natural selection. These findings will allow researchers to make better predictions of how a gene drive will proceed and to improve the design of future gene drives to decrease the likelihood of resistance.. Tony Nolan adds: Reducing the numbers of mosquito vectors has been the most effective tool to date for the control of malaria, so self-sustaining gene drives designed with this purpose have great potential. However gene drives are not a silver bullet and just like antibiotics can select for resistance in bacteria, gene drives can be susceptible to resistance at their target site. The novelty of this study is not that resistance emerges - we have been planning strategies to deal with this from the start - but that it documents the way it emerges and the way it is selected over generations. This work will help a lot in planning for and managing the emergence of ...
In August, the first cloned pig with Alzheimers disease will be born in Denmark.. Responsible for this breakthrough are scientists from the universities of Copenhagen and Århus, Denmark in their effort towards finding a cure for Alzheimers disease.. The said pigs have been genetically modified to function as animal models for Alzheimers disease - a brain disorder suffered by an approximately 24 million people globally.. According to Ingrid Brück Bøgh from the Department of Large Animal Sciences, University of Copenhagen:. "In the light of the intense focus on medical research at the University of Copenhagen and the continuous expansion of the pharmaceutical industry in Denmark, the ability to produce transgenic pig models for human diseases is a major prerequisite for future progress in this area.. The upcoming birth of these transgenic pig models constitutes a fantastic success for us. It is also a demonstration of the excellent cross-disciplinary collaboration between the experts at both ...
One of the main concerns over gene drive is its potential long‐term effects. The designated effects on the targeted populations will be fast-within a few years-while long‐term effects on ecosystems may take decades to appear and are extremely unpredictable. The time frame of gene drive perfectly fits the economic development strategies dominant today in agribusiness, with a focus on short‐term return on investments and disdain for long‐term issues. The current economical system based on productivity, yields, monoculture, and extractivism [7] is a perfect match for the operating mode of gene drive. In addition, agri‐food industry decision centers are rarely located near the production sites. They will be inclined to disregard the ecological long‐term risks as they only concern local human populations in their exploited lands. Gene drive then becomes an issue of environmental justice.. The scarce use of gene drive, if concerted, cautious and controlled, may not cause any ecological ...
One of the main concerns over gene drive is its potential long‐term effects. The designated effects on the targeted populations will be fast-within a few years-while long‐term effects on ecosystems may take decades to appear and are extremely unpredictable. The time frame of gene drive perfectly fits the economic development strategies dominant today in agribusiness, with a focus on short‐term return on investments and disdain for long‐term issues. The current economical system based on productivity, yields, monoculture, and extractivism [7] is a perfect match for the operating mode of gene drive. In addition, agri‐food industry decision centers are rarely located near the production sites. They will be inclined to disregard the ecological long‐term risks as they only concern local human populations in their exploited lands. Gene drive then becomes an issue of environmental justice.. The scarce use of gene drive, if concerted, cautious and controlled, may not cause any ecological ...
During vertebrate embryogenesis, the cranial neural crest (CNC) forms at the neural plate border and subsequently migrates and differentiates into many types of cells. The transcription factor Snai2, which is induced by canonical Wnt signaling to be expressed in the early CNC, is pivotal for CNC induction and migration in Xenopus. However, snai2 expression is silenced during CNC migration, and its roles at later developmental stages remain unclear. We generated a transgenic X. tropicalis line that expresses enhanced green fluorescent protein (eGFP) driven by the snai2 promoter/enhancer, and observed eGFP expression not only in the pre-migratory and migrating CNC, but also the differentiating CNC. This transgenic line can be used directly to detect deficiencies in CNC development at various stages, including subtle perturbation of CNC differentiation. In situ hybridization and immunohistochemistry confirm that Snai2 is re-expressed in the differentiating CNC. Using a separate transgenic Wnt reporter line
In the past decade, researchers have engineered an array of new tools that control the balance of genetic inheritance. Based on CRISPR technology, such gene drives are poised to move from the laboratory into the wild where they are being engineered to suppress devastating diseases such as mosquito-borne malaria, dengue, Zika, chikungunya, yellow fever and West Nile. Gene drives carry the power to immunize mosquitoes against malarial parasites, or act as genetic insecticides that reduce mosquito populations.. Although the newest gene drives have been proven to spread efficiently as designed in laboratory settings, concerns have been raised regarding the safety of releasing such systems into wild populations. Questions have emerged about the predictability and controllability of gene drives and whether, once let loose, they can be recalled in the field if they spread beyond their intended application region.. Now, scientists at the University of California San Diego and their colleagues have ...
Scientists have issued a call to ensure that the use of gene drives in conservation will only affect local populations. Gene drives promote the inheritance of a particular genetic variant to increase its frequency in a population. In conservation, a gene drive could spread infertility and ultimately eliminate a pest population.
Transgenic animals have become valuable tools for both research and applied purposes. The current method of gene transfer, microinjection, which is widely used in transgenic mouse production, has only had limited success in producing transgenic animals of larger or higher species. Here, we report a linker based sperm-mediated gene transfer method (LB-SMGT) that greatly improves the production efficiency of large transgenic animals. The linker protein, a monoclonal antibody (mAb C), is reactive to a surface antigen on sperm of all tested species including pig, mouse, chicken, cow, goat, sheep, and human. mAb C is a basic protein that binds to DNA through ionic interaction allowing exogenous DNA to be linked specifically to sperm. After fertilization of the egg, the DNA is shown to be successfully integrated into the genome of viable pig and mouse offspring with germ-line transfer to the F1 generation at a highly efficient rate: 37.5% of pigs and 33% of mice. The integration is demonstrated again by FISH
A number of other respondents have brought up developments in gene drives (e.g. development of mammalian gene drive systems). In 2018 ETC Group released an overview report on the application of gene drive systems to agriculture (See Forcing the Farm: http://www.etcgroup.org/content/forcing-farm) which we hereby submit for consideration of new developments in the field. Our research show that there is increasing work on application of gene drive systems to agricultural pests (Especially insects and aphids) as well as to applying gene drive as a breeding tool for livestock. To date we cannot identify successful use of CRISPR gene drive systems in plants (although perhaps others on this forum can correct that) or any working examples of so called local or controllable gene drive systems beyond theoretical models. Given that some of these theoretical ideas are advanced in policy fora as if they exist I think it may be important for the moderators in their summary of this forum to also point to and ...
Strategies of reversing, preventing, and controlling the unfold and results of gene drives. Snapchat and even Facebooks own Instagram are getting more clicks from the kids lately than the getting old social network. Gone are the days when folks melted for concern of the place to get data or data for their utilization.. For many, Fb has turn out to be an integral part of day-to-day life. Thanks for sending your work entitled Regarding RNA-Guided Gene Drives for the Engineering of Wild Populations†for consideration at eLife. • Energy-down for one time frame every day ...
Behrendorff, N, Behrendorff, J, Wall, A, Scott, E and Thorn, P (2011). A Novel Transgenic Zebrafish Model for Studying Secretion in the Exocrine Pancreas. In: Abstracts of Papers Submitted to the 42nd Annual Meeting of the American Pancreatic Association. 42nd Annual Meeting of the American Pancreatic Association, Chicago, IL, United States, (1314-1314). 2-5 November 2011. doi:10.1097/MPA.0b013e318232ea83 ...
Time-lapse movie of the equatorial region of E-cadherin mutant lens epithelium combined with a zebrafish transgenic line, Tg(h2afva:GFP) from 33 to 45 hpf. Different rows of cells are indicated by color: Row 1, light blue; Row 2, green; Row 3, yellow; Row 4, orange; Row 5, red; Row 6, pink.. ...
He has led the movement to shine the spotlight," says Marc Lipsitch, an epidemiologist at Harvard University involved in biosafety issues. "Its not that common to be at the beginning of your career and already be thinking of the moral, ethical, and policy implications.". A gene drive is a genetic addition made to a mosquito or other organism that is able to spread through a population of animals in the wild and potentially act as a doomsday gadget, driving it out of existence. The technology presents challenges not only because it could extinguish a species but because by its very nature it can spread widely, including as the result of a lab accident.. "This is the perfect example of a technology that needs to be community-guided from the beginning," says Esvelt. "Its meaningless to talk about engaging the public in science if science is still going to develop the product and then say, What do you think?". Esvelt says hes started a new project, called Responsive Science, along with MIT ...
Gene drive systems distort the rule that there is a 50:50 chance of a gene copy being passed on. This promotes the inheritance of a particular copy of a gene from the parent to offspring. When coupled to a genetic trait that affects an individuals survival or ability to reproduce, it becomes a powerful tool that can be used for population control or even local elimination.
In lab populations of genetically engineered mosquitoes, mutations arose that blocked the gene drive’s spread and restored female fertility.
Read chapter 3 Case Studies to Examine Questions About Gene-Drive Modified Organisms: Research on gene drive systems is rapidly advancing. Many proposed a...
Public fears and concerns towards transgenic plant or animal have been there for years even though the scientific expects in China, at least, acclaimed that they are safe. The reason why people are afraid of transgenic technology and furthermore reject it is that public people dont know it at all, or have limited understanding.. You must have read lots of articles explaining why transgenic technology is safe, or on the other hand, dangerous. And here I believe current products of transgenic technology in your daily life are safe and healthy, because most of them are protein product indeed. It is the exogenous genes are translocated and expressed in the host, but the outcome is protein according to the known central dogma, hence the protein cannot hybridize with your genome so that you will not be mutated to Rice-Man. No need to panic.. ...
Transgenic mosquitoes that could eradicate malaria. Unfortunately, it is potentially the most hazardous genetically modified organism (GMO) to have be
Gene drive is a mechanism that can promote the preferential inheritance of a beneficial genetic trait, thereby increasing its prevalence in a population. A variety of gene drive mechanisms occur in nature that can cause specific genetic elements to spread throughout populations in varying degrees. Researchers have long sought to harness these naturally occurring gene drive mechanisms to prevent the transmission of mosquito or other insect-borne diseases that pose some of societys most intractable public health problems.. ...
Energy homeostasis is accomplished through a highly integrated and redundant neurohumoral system. Recently, novel molecular mediators and regulatory pathways for feeding and body weight regulation have been identified in the brain and the periphery. Because of the multitude and complexity of disturbances in energy intake, expenditure, and partitioning that are associated with obesity, it has been difficult to determine which abnormalities are causative versus less important phenomena that are consequences of the altered neuroendocrine and metabolic milieu. Transgenic technology has provided new opportunities to modify the complex body weight-regulating system and to assess the relative importance of the individual components. Observations of mutant mice have shed new light on the understanding of energy homeostasis equation. Once created, transgenic animal models may be useful in assessing the efficacy or determining the mode of action of potential new therapeutic agents. However, the ...
Advances in single-cell technologies have revealed vast differences between cells once thought to be in the same category, calling into question how we define cell type in the first place ...
Zebrafish have been widely used as a model system for studying developmental processes, but in the last decade, they have also emerged as a valuable system for modeling human disease. The development and function of zebrafish organs are strikingly similar to those of humans, and the ease of creating mutant or transgenic fish has facilitated the generation of disease models. Here, we highlight the use of zebrafish for defining disease pathways and for discovering new therapies. ...
Our transgenic rabbits allow for biopharming, high-yield recombinant protein & antibody production. Partnerships are available. Click to learn more.
091011 - Animais Transg nicos: Conceito, Metodologias e Aplica es - Transgenic animals: concept, methodologies and applications | Veterinaria.org . La primera comunidad veterinaria de habla hispana con presencia en Espa a y Am rica del Sur.
The simpler procedure, which uses a single tagged secondary antibody, can often be used (8). Animals are best perfusion fixed with PAF (9 see Chapter 45). The
β-Amyloid (Aβ)-induced toxicity and oxidative stress have been postulated to play critical roles in the pathogenic mechanism of Alzheimer disease (AD). We investigated the in vivo ability of a mitochondria-targeted antioxidant, MitoQ, to protect against Aβ-induced toxicity and oxidative stress in a …
TY - JOUR. T1 - Analysis of the N-glycans of recombinant human Factor IX purified from transgenic pig milk. AU - Gil, Geun Cheol. AU - Velander, William H.. AU - Van Cott, Kevin E.. PY - 2008/7/1. Y1 - 2008/7/1. N2 - Glycosylation of recombinant proteins is of particular importance because it can play significant roles in the clinical properties of the glycoprotein. In this work, the N-glycan structures of recombinant human Factor IX (tg-FIX) produced in the transgenic pig mammary gland were determined. The majority of the N-glycans of transgenic pig-derived Factor IX (tg-FIX) are complex, bi-antennary with one or two terminal N -acetylneuraminic acid (Neu5Ac) moieties. We also found that the N-glycan structures of tg-FIX produced in the porcine mammary epithelial cells differed with respect to N-glycans from glycoproteins produced in other porcine tissues. tg-FIX contains no detectable Neu5Gc, the sialic acid commonly found in porcine glycoproteins produced in other tissues. Additionally, we ...
CRISPR gene drive has recently been proposed as a promising technology for population management, including in conservation genetics. The technique would consist in releasing genetically engineered individuals that are designed to rapidly propagate a desired mutation or transgene into wild populations. Potential applications in conservation biology include the control of invasive pest populations that threaten biodiversity (eradication and suppression drives), or the introduction of beneficial mutations in endangered populations (rescue drives). The propagation of a gene drive is affected by different factors that depend on the drive construct (e.g. its fitness effect and timing of expression) or on the target species (e.g. its mating system and population structure). We review potential applications of the different types of gene drives for conservation. We examine the challenges posed by the evolution of resistance to gene drives and review the various molecular and environmental risks associated with
TY - JOUR. T1 - Expression of cytochrome P45011B1 mRNA in the brain of normal and hypertensive transgenic rats. AU - Erdmann, Bettina. AU - Gerst, Hellmut. AU - Lippoldt, Andrea. AU - Buelow, Hannes E.. AU - Ganten, Detlev. AU - Fuxe, Kjell. AU - Bernhardt, Rita. PY - 1996/9/9. Y1 - 1996/9/9. N2 - Cytochrome P45011B1 (11β-hydroxylase) was detected in the brain of male rats by in situ hybridization methods. Normal Sprague-Dawley rats were compared to the transgenic strain TGR(mRen2)27, characterized by the expression of the murine Ren-2(d) renin gene and the development of severe hypertension. Specific riboprobes were generated by in vitro transcription of a 152 base-pair long cDNA template. 35S-labeled riboprobes were hybridized to cryostat sections from adrenal glands and from two different levels of the brain using standard protocols and varying washing conditions. After exposure of the radiolabeled sections to X-ray film, the signals were quantified and compared. Following autoradiography ...
J. Pathol. 163:2155-2164. , 2001, Amyloid p protein forms ion channels: implications for Alzheimers disease pathophysiology. FASEB J. 15: 2433-2444. -C, Hall, D. , Mathis, C. , 2001, Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging 22:217-226. , 2004, Single chain variable fragments against B-amyloid (AB) can The Contribution of Microscopy to the Study of Alzheimers Disease 39 inhibit AB aggregation and prevent AB-induced neurotoxicity. Interestingly, a rapidly-formed but transient nanocrystalhne from of a 14-amino acid Ap peptide has been described by Otzen and Oliveberg (2004). Using TEM these workers showed that the nanocrystalline form of this peptide leads to the formation of a tangled aggregate (hours) and amyloid fibres (days). 2 Ap protofilaments Definition of the P-sheet-containing protofilament that can be formed by Ap and several other fibril-forming amyloidogenic peptides is by no ...
Our lab studies the alternative splicing of pre-mRNAs. In Drosophila, alternative splicing plays a central role in sex determination. We have been using the sex-determination system to study factors that influence alternative splicing and to determine the mechanisms by which they do so. Several of the proteins we are studying belong to the serine/arginine-rich (SR) family of splicing factors. These proteins usually bind to sequences located within exons, known as exonic splicing enhancers (ESEs) and activate nearby splice sites. We have found that an SR factors can repress splicing when bound within an intron. Using in vitro splicing assays and Drosophila genetics we are determining how splicing activation and repression differ. A second interest of the lab is in genetic models for muscular dystrophy. Recently we have developed a transgenic Drosophila model for facioscapulohumeral muscular dystrophy (FSHD) a poorly understood late-onset disease that affects specific muscle groups in humans. We ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
This study has demonstrated that microparticle bombardment is a simple and efficient technique for generating stable transgenic lines in C. elegans. We have found that a substantial proportion of the transgenic lines generated by microparticle bombardment contain a low number of copies of the transforming DNA integrated into a chromosome, resulting in stable transmission of the transgenic DNA over many generations. A critical factor in the success of this microparticle bombardment transformation strategy is the use of a selectable cotransformation marker to identify rare transformed animals within the population of bombarded animals and their descendants. For the experiments described in this article, we bombarded unc-119 mutants with plasmids containing an unc-119 rescuing fragment and were able to identify transformed animals based on their ability to survive starvation and on their non-Unc phenotype.. In some cases, the unc-119 gene may be an unsuitable cotransformation marker due to ...
Regulating transgenic technology in China: Law, regulation, and public policy. Yinliang Liu Dr. of Laws, M.S. (Biology), Associate Professor Vice Director, Institute of IP Law Director, Bio-Law Research Center China University of Political Science and Law 3 December 2007. Outline. Slideshow 449280 by tirza
Confocal micrograph of the brain of a transgenic zebrafish embryo. Some neurons express the green fluorescent protein (GFP) - shown in green under the...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Not everyone is convinced that this optimistic view is warranted. "Its a false security," said Ethan Bier, a geneticist at the University of California, San Diego. He said that while such a strategy is important to study, he worries that researchers will be fooled into thinking that forms of resistance offer "more of a buffer and safety net than they do.". And while mathematical models are helpful, researchers stress that models cant replace actual experimentation. Ecological systems are just too complicated. "We have no experience engineering systems that are going to evolve outside of our control. We have never done that before," Esvelt said. "So thats why a lot of these modeling studies are important-they can give us a handle on what might happen. But Im also hesitant to rely on modeling and trying to predict in advance when systems are so complicated.". Messer hopes to put his theoretical work into a real-world setting, at least in the lab. He is currently directing a gene drive ...
In this study we describe a model system that allows continuous in vivo observation of the vertebrate embryonic vasculature. We find that the zebrafish fli1 promoter is able to drive expression of enhanced green fluorescent protein (EGFP) in all blood vessels throughout embryogenesis. We demonstrate …
Penn State and Agariger, Inc. have patented the technology of making new transgenic mushrooms, which have increased hope of using mushrooms for the mass
Transgenic mice and methods of preparing such mice are disclosed. The mice exhibit decreased platelet counts and/or megakaryocyte leukemia.
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Genetically modified animals[edit]. Transgenic animals have genetically modified DNA. Animals are different from plants in a ... "The Regulation of Genetically Modified Foods".. *^ a b c d John Davison (2010)"GM plants: Science, politics and EC regulations ... McHughen A, Smyth S (2008). "US regulatory system for genetically modified [genetically modified organism (GMO), rDNA or ... FDA page for GM Food. *^ "Guide to U.S. Regulation of Genetically Modified Food and Agricultural Biotechnology Products" (PDF) ...
Genetically modified foods[edit]. Main article: Genetically modified organism. The use of genetically modified seeds to grow ... Farming of animals[edit]. More intensive forms of animal farming have largely replaced traditional methods of raising pigs, ... The Food and Drug Administration generally considers a food with origins from genetically modified organisms (GMO) to be as ... USDA Animal Plant Health Inspection Service. Retrieved 2013-11-15.. *^ Comis, D (July 2003). "An Environmental Look at ...
Genetically modified mice are the most common animal model for transgenic research. Transgenic mice are currently being used to ... Oncomice are another genetically modified mouse species created by inserting transgenes that increase the animal's ... "Background: Cloned and Genetically Modified Animals". Center for Genetics and Society. April 14, 2005. "Knockout Mice". ... Transgenic or genetically modified organisms, be they bacteria, viruses or fungi, serve all kinds of research purposes. ...
... model animals and the production of agricultural or pharmaceutical products. The genetically modified animals include animals ... is the creation and use of genetically modified crops or genetically modified livestock to produce genetically modified food. ... The Regulation of Genetically Modified Food Glossary definition of Genetically Modified: "An organism, such as a plant, animal ... Genetically modified mice are the most common genetically engineered animal model. They have been used to study and model ...
Animal Behaviour. 50: 1325-1339. doi:10.1016/0003-3472(95)80048-4. Purvis, A; Agapowe, P-M; Gittleman, JL; Mace, GM (2000). " ... This simple SDM is often modified through the use of range data or ancillary information- such as elevation or water distance. ... Animals need certain resources to survive, and when these resources become rare during certain parts of the year animals tend ... This is seen in juvenile animals that are immobile and strongly dependent upon parental care. For example, the bald eagle's ...
... which has jurisdiction over all genetically modified (GM) animals, including fluorescent zebra fish, since they consider the ... "Genetically Engineered Animals". fda.gov. "Regulation of Genetically Engineered Animals Containing Heritable Recombinant DNA ... It is sold only in the United States, where it remains the only genetically modified animal to be publicly available. The ... Although not originally developed for the ornamental fish trade, it is one of the first genetically modified animals to become ...
Genetically modified seeds and animals are excluded. While organic is fundamentally different from conventional because of the ... Genetically modified organisms, nanomaterials, human sewage sludge, plant growth regulators, hormones, and antibiotic use in ... A key characteristic of organic farming is the rejection of genetically engineered plants and animals. On 19 October 1998, ... Although GMOs are excluded from organic farming, there is concern that the pollen from genetically modified crops is ...
... about the potential for cross-pollination occurring between the genetically modified alfalfa and non-genetically modified ... This case arose from the 2005 decision made by the Animal and Plant Health Inspection Service (APHIS), an arm of the U.S. ... agricultural health and regulating genetically modified organisms. APHIS has the authority to regulate any genetically ... The decision allowed Monsanto to sell genetically modified alfalfa seeds to farmers, and allowed farmers to plant them, grow ...
These buffers would provide a great habitat for plants and animals.. A lot of people do not like genetically modified organisms ... Genetically Modified Plants[edit]. Plants are most commonly modified to be resistant to specific herbicides or pathogens, but ... Genetically modified plants are a good answer to the problem of not enough crops to go around. These plants can be engineered ... Genetically modified plants can be implemented to slow down the effects of the abiotic stressors. This allows more crops to be ...
A ban on genetically modified organisms. Forced full Australian ownership of Australian network infrastructure (like ... Using dole workers to eradicate major plant and animal pests. Reduced insurance costs for local governments and community ...
Genetically modified food controversies Pollution - Nonpoint source pollution • Point source pollution • Air pollution - ... Overpopulation in companion animals • Tragedy of the commons • Gender Imbalance in Developing Countries • Sub-replacement ... Intensive animal farming • Intensive crop farming • Irrigation • Monoculture • Nutrient pollution • Overgrazing • Pesticide ...
"Genetically Engineered Animals - Oxitec Mosquito". US Food and Drug Administration; Animal and Veterinary. 2017-02-05. ... Julia Paoli: Genetically Modified Mosquitoes Pave the Way for Dengue Fever Prevention, Nature Publishing Group, 15 September ... Genetically modified organism Sterile insect technique The Oxitec approach. Oxitech Cookson, Clive (23 April 2015). "'Lethal ... Oxitec is working to develop a genetically modified version of Aedes aegypti to help control the transmission of mosquito borne ...
By being able to genetically modify a monkey, a new breakthrough in technology was formed. ANDi was created in the hope of ... Sawicki, Stephen (2001). "Genetic Engineering Results in First Primate Deliberately Mutated". Animals: 2. McCall, WilliM. "Meet ... ANDi is the first genetically modified rhesus monkey who was born at Oregon Health Sciences University (OHSU) on October 2, ... "GM monkey passes jellyfish gene to offspring". New Scientist. Retrieved 13 December 2013. ...
Background: Cloned and Genetically Modified Animals [online]. Center for Genetics and Society, April 14, 2005. Dostupné online ... Genetically Modified Foods: Harmful or Helpful? [online]. 2000. Dostupné online. (anglicky). Je zde použita šablona {{Cite web ... Risk assessment of genetically modified crops for nutrition and health. Nutr. Rev.. 2009, s. 1-16. DOI:10.1111/j.1753-4887.2008 ... 20 questions on genetically modified foods [online]. World Health Organization, 2010. Dostupné online. (anglicky). Je zde ...
Better animal models[edit]. Genetically modified animals represent an important instrument of modern biomedical research. In ... Disease models in genetically modified animals are mainly in rodents, such as mice and rats. However, they cannot adequately ... They see the following advantages in the use of genetically modified organisms in animal experiments: *Possibility of ... Alternatives to animal experiments[edit]. "Animal experiments will remain necessary in biomedical research for the foreseeable ...
"EFSA - Guidance of the GMO Panel: Guidance Document on the ERA of GM animals". EFSA Journal. 11 (5): 3200. 2013. doi:10.2903/j. ... "FDA Approves Genetically Modified Mosquitoes For Release In Florida". Retrieved 2016-08-07. Regalado, Antonio. "Bill Gates ... One possible application is to genetically modify mosquitoes and other disease vectors so they cannot transmit diseases such as ... Engineered gene drives have been proposed to provide an effective means of genetically modifying populations or even whole ...
nola.com Animals portal Birds portal Africa portal Cooper, J. C. (1992). Symbolic and Mythological Animals. New York, NY: ... Close-up of head: Note the highly modified feathers Close-up of head: Note the long eyelashes to protect the eyes Foot: Note ... Skadhauge, E; Warüi CN; Kamau JM; Maloiy GM (1984). "Function of the lower intestine and osmoregulation in the ostrich: ... Hence, it is plausible to state that metabolic rate in animals with larger masses is greater than animals with a smaller mass. ...
Genetically modified organisms contain genetic material that is altered through genetic engineering. Genetically modified crops ... Forestry operations, grazing of animals and hunting of animals are regulated. Exploitation of habitat or wildlife is banned. ... but advances in genetic engineering have led to tighter laws covering distribution of genetically modified organisms, gene ... Greater species diversity of animals may or may not decrease disease prevalence on those animals (Synthesis of 45 experimental ...
Animals need certain resources to survive, and when these resources become rare during certain parts of the year animals tend ... This simple SDM is often modified through the use of range data or ancillary information- such as elevation or water distance. ... Purvis, A; Agapowe, P-M; Gittleman, JL; Mace, GM (2000). "Non-random extinction and the loss of evolutionary history". Science ... Banerjee, B. (1976). Variance to mean ratio and the spatial distribution of animals. Birkhäuser Basel. pp. 993-994.. ...
"Genetically modified crops: steady growth in Ontario and Quebec". Statistics Canada. 6 December 2002. Retrieved 28 November ... Disease of plants and animals can break an agricultural producer. Tuberculosis in animals was an early threat, and cattle ... The domestication of various farm animals meant that corresponding industries such as feedlots, animal husbandry and meat ... "Animal Health Scrapies Manual of Procedures Module 1 and 2". Canadian Food Inspection Agency. Government of Canada. Archived ...
Its margarines are made without animal products or genetically modified ingredients. The original Nuttelex used to contain nuts ...
The Regulation of Genetically Modified Food Glossary definition of Genetically Modified: "An organism, such as a plant, animal ... A 'GMO' is a genetically modified organism.", Retrieved 2 November 2012. "The Regulation of Genetically Modified Foods". Staff ... McHughen A, Smyth S (2008). "US regulatory system for genetically modified [genetically modified organism (GMO), rDNA or ... including genetically modified food plants. The EPA regulates genetically modified plants with pesticide properties, as well as ...
... is the first medicine produced using genetically engineered animals. GTC states that one genetically modified goat can ... Larkin, Catherine (February 6, 2009). "GTC Drug Is First From Genetically Engineered Animals". Bloomberg. Retrieved February 7 ... It is made from the milk of goats that have been genetically modified to produce human antithrombin, a plasma protein with ... "HSUS Position Statement: Genetic Engineering of Animals". Archived from the original on December 3, 2008. Soler E, Thépot D, ...
Genetically modified foodsEdit. Main article: Genetically modified food controversies. There is a scientific consensus[45][46][ ... "Animals. 1 (1): 186-199.. *^ Reus, E.; Olivier, D. (2007). "Mind-matter for animals matters: Science and the denial of animal ... "Frequently asked questions on genetically modified foods". World Health Organization. Retrieved February 8, 2016. Different GM ... "Genetically modified foods and health: a second interim statement" (PDF). British Medical Association. March 2004. Retrieved ...
Also, the introduction of genetically modified plants and animals is of concern. Crops engineered to produce pharmaceuticals ( ... of nanotechnology Environmental implications of nanotechnology Health implications of nanotechnology Genetically modified food ...
A genetically modified tomato, or transgenic tomato, is a tomato that has had its genes modified, using genetic engineering. ... The first commercially available genetically modified food was a tomato engineered to have a longer shelf life (the Flavr Savr ... As well as aiming to produce novel crops, scientists produce genetically modified tomatoes to understand the function of genes ... Tomatoes are used as a model organism in scientific research and they are frequently genetically modified to further ...
Food and Drug Administration is weighing whether to allow a genetically engineered Atlantic salmon to be the first such animal ... The following are four other genetically engineered animals in development or approved by the FDA. ... They hope it will be the second FDA-approved genetically engineered food animal. ... Food and Drug Administration is weighing whether to allow a genetically engineered Atlantic salmon to be the first such animal ...
Genetic modification of an animal involves altering its genetic material by adding, changing or removing certain DNA sequences ... 1. What are genetically modified (GM) animals?. A genetically modified animal is one whose genetic material has been altered by ... Are there GM animals or food and feed from GM animals currently authorised in the EU?. No GM animals, or food or feed from GM ... impacts of the GM animal on biogeochemical processes; and (7) impacts of the GM animal on human and animal health. ...
... heres a look back at some of the most recognized animals created in labs. ... As modified mosquitoes are unleashed on the Zika virus, ... In 2015, a genetically modified cow gave birth to a healthy ... 12 Genetically Engineered Animals That Changed Modern Science. As modified mosquitoes are unleashed on the Zika virus, heres a ... Last year, the Food and Drug Administration approved the first genetically modified animal for consumption, much to the chagrin ...
... to consider the ethical and welfare issues about the use of genetically modified and cloned animals. ... We provide resources to assist researchers and members of animal ethics committees (AECs) ... care and use of genetically modified and cloned animals for scientific purposes (2007) (the GM Guidelines). However, because ... If you are involved with the use of genetically modified or cloned animals, you may have been using the Guidelines for the ...
If youre worried about potential health problems with genetically modified crops, pay attention: A new paper published in ... Ireland Says Not In This Country: Bans Genetically Modified Crops. UK Scientist Suggests Rebranding GM Crops As "Vaccinated" To ... If youre worried about potential health problems with genetically modified crops, pay attention: A new paper published in ... Read the original research: Genetically modified crops safety assessments: present limits and possible improvements. More on ...
FDA issues rules for genetically modified animals. Animals genetically engineered to produce drugs and healthier foods will be ... that the FDA will not require labeling of genetically engineered animals that are sold as food. Genetically engineered animals ... FDA proposed today that they will only review genetically engineered animals for their safety as food, and will not require any ... the antibiotic that is genetically engineered into the animal will always be present. We are concerned both about the potential ...
Action Alert: Genetically Modified Animals Step Closer to Your Dinner Plate 3 Min Read / Activism ... Will products containing genetically modified animal products be labeled as such?) to environmental impacts (Will genetically ... Fresh off the newswire is this story about the use of genetically modified animals as a food source. The story comes from the ... The Food and Drug Administration took a step Thursday toward considering proposals to sell genetically modified animals as food ...
... genetically modified animals are a whole different playing field of bizarre. Science has made a ton of advancements in changing ... animal DNA, especially with CRISPR, a genome editing tool that allows scientists to edit genomes with ... ... If you thought genetically modified crops were controversial, ... Insane Ways Scientists Are Genetically Modifying Animals Mariel ... If you thought genetically modified crops were controversial, genetically modified animals are a whole different playing field ...
Individual identification of GM animals is essential to improv ... GM) animals has generated a demand for accurate and unique ... The diffusion of genetically modified (GM) animals has generated a demand for accurate and unique identification to assure ... Individual identification of GM animals is essential to improve safety and traceability, as well as to fulfill the present and ... Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Box 7023, SE-750 07 Uppsala, Sweden. ...
... translatable genetically-modified mouse and rat models for research, drug discovery, and humanized immune systems studies. ... Genetically Engineered Animal Models. start an order , print this page , share this page Genetically Engineered Animal Models. ... Design precise, translatable, genetically-engineered animal models for preclinical research and drug discovery. Taconic ... Taconic is a fully-licensed provider of genetically-engineered animal model generation services, able to partner with you at ...
A variety of genetically modified corn was found to cause signs of hormonal changes and liver and kidney toxicity in rats. All ... liver toxicity in animal studies. by David Gutierrez, staff writer A variety of genetically modified corn that was approved for ... I find it interesting that the FDA believes U.S. consumers should not be allowed to know which foods are genetically modified ... The rats who ate modified corn were found to exhibit signs of liver and kidney toxicity, as well as signs of hormonal changes. ...
Are you happy to eat genetically modified food?. Yes No Results New Posts - Futurist Keynote Speaker * Watch my latest Futurist ... Animal cloning has been going on for over thirty years and making new animals with new genes is also now quite routine, with ... Patents should not be given for sections of normal human genes, nor for human beings, nor for genetically altered animals or ... A Gene Charter - human cloning, GM food, transgenic animals Written by Patrick Dixon ...
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The document, Guidance on the environmental risk assessment of genetically modified animals, which focuses on GM fish, insects ... environmental impacts of the techniques used to rear or keep the GM animal; and the impact of the GM animal on human and animal ... Thus the ERA of GM animals involves collecting, assessing and, where appropriate, generating information about the GM animal to ... the non-GM animal with which the GM animal is compared during the safety evaluation).. In the final chapter of the draft ...
... reports that the performance and health of food-producing animals consuming genetically engineered feed, first introduced 18 ... years ago, has been comparable to that of animals consuming non-GE feed. ... Amino acids in animal feed positively affect environment. Animal feed event to address non-genetically modified product ... FIAAP Animal Nutrition Conference. Animal Ag Alliance Stakeholders Summit. Please enable JavaScript to view the comments ...
Fate of transgenic DNA and evaluation of metabolic effects in goats fed genetically modified soybean and in their offsprings - ... Genetically modified soya bean in sheep feeding: detection of DNA fragments in suckling lambs. Proceedings of 12th AAAP Animal ... Assessing the transfer of genetically modified DNA from feed to animal tissues. Transgenic Research 14, 775-784. ... Fate of genetically modified maize DNA in the oral cavity and rumen of sheep. British Journal of Nutrition 89, 159-166. ...
Methods and Mechanisms of Genetic Manipulation and Cloning of Animals: Assists policymakers in evaluating the appropriate ... For genetically modified (GM) plants and the animal biotechnologies reviewed by FDA, the evaluation has included comprehensive ... In this example, the comparator database is not derived from animals that have been genetically modified by the application of ... Regulatory control of genetically modified (GM) foods: Likely developments. Toxicol Lett 127:341-349. ...
GM Salmon?, FDA image. After a seemingly endless period of review, the FDA has approved the genetically modified (GM) ... Perspectives: FDA approves 1st GM animal (fast growing salmon) to eat. November 19, 2015 Paul Knoepfler Uncategorized 14 ... and there were no qualitative differences in these proteins between GM and non-GM-amago salmons. These results indicate that ... GM Salmon, FDA image. Share this:. *Click to share on Twitter (Opens in new window) ...
GM) cows. And were talking mad-scientist GMOs here - animals that boast genetic traits utterly impossible to create in ... China is introducing a new wave of genetically modified ( ... China is introducing a new wave of genetically modified (GM) ... Tagscows, tuberculosis, bovine tuberculosis, china, genetically modified animals, livestock, domestic livestock, GMOs ... which details how early testing with a new generation of GM cows has revealed that modified herds can completely resist low ...
A GM house plant that breaks down indoor pollutants linked to cancer may do a better job ... If you live in Canada, you might soon be able to buy a genetically modified fluorescent houseplant that removes cancer-linked ... Read more: Altered animals: Creatures with bonus features. Would it be simpler just to open a window? "Oh, yes, sure," says ... A house plant has been genetically modified to break down indoor pollutants. Mark Stone/University of Washington ...
Genetically modified animals[edit]. Transgenic animals have genetically modified DNA. Animals are different from plants in a ... "The Regulation of Genetically Modified Foods".. *^ a b c d John Davison (2010)"GM plants: Science, politics and EC regulations ... McHughen A, Smyth S (2008). "US regulatory system for genetically modified [genetically modified organism (GMO), rDNA or ... FDA page for GM Food. *^ "Guide to U.S. Regulation of Genetically Modified Food and Agricultural Biotechnology Products" (PDF) ...
The aim of this study was to use a known animal model to determine the safety of the genetically modified (GM) rice T1C-1. The ... No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed ... The aim of this study was to use a known animal model to determine the safety of the genetically modified (GM) rice T1C-1. The ... However, as genetically modified (GM) crops are becoming an increasing feature of agricultural landscapes, several ...
GM) plants are increasingly used for food production and industrial applications. As the global population has surpassed 7 ... Safety risks for animals fed genetic modified (GM) plants. Vet Res Commun. 2005;29 Suppl 2:13-8.PubMedCrossRefGoogle Scholar ... Guidance document of the scientific panel on genetically modified organisms for the risk assessment of genetically modified ... Review of animal models designed to predict the potential allergenicity of novel proteins in genetically modified crops. Regul ...
Products from some of these animals, such as milk from GM cows, may end up in the food chain. Genetically modifying mammals ... GM animals → European consultation on GM animals European consultation on GM animals. The European Food Safety Authority (EFSA ... GM mammals. The consultation also covers GM mammals, including farm animals such as cows, pets such as cats, and wild animals ... You can read more about some of these applications elsewhere on this website: GM fish, GM insects and GM and cloned animals. ...
Max Planck scientists analysing the release of genetically modified insects into the environment have found that access to ... the release of genetically modified animals is still at a relatively early stage. A team of scientists from the Max Planck ... Giving genetically modified insects a fair trial. Large numbers of genetically modified mosquitoes are currently being released ... While genetically modified plants have already been introduced into the wild on a large scale in some parts of the world, ...
  • In February 2009, the FDA approved GTC Biotherapeutics Inc's modified goats used to produce an anti-clotting therapy for people with a rare disorder called hereditary antithrombin deficiency. (ibtimes.com)
  • Should his goats or someone else's transgenic animals come before the FDA, "we need them to make a decision," he said. (latimes.com)
  • China is introducing a new wave of genetically modified (GM) cows. (natureworldnews.com)
  • That's at least according to a study recently published in the journal Proceedings of the National Academy of Sciences ( PNAS ) , which details how early testing with a new generation of GM cows has revealed that modified herds can completely resist low levels of Mycobacterium bovis infection - the cause of B-TB. (natureworldnews.com)
  • The consultation also covers GM mammals, including farm animals such as cows, pets such as cats, and wild animals such as rabbits, all of which could cause harm if they are released or escape into the environment. (genewatch.org)
  • True organic beef would become an impossibility since all cows would be potentially exposed to the GM alfalfa. (anh-usa.org)
  • A unique new study led by Professor Gilles-Eric Seralini has shown that the first genetically-modified GM crop commercialized for animal feed, Bt176 from Novartis (now Syngenta), was toxic to cows over the long-term. (gmoseralini.org)
  • The review, led by UC Davis animal scientist Alison Van Eenennaam, examined nearly 30 years of livestock-feeding studies that represent more than 100 billion animals. (wattagnet.com)
  • Titled " Prevalence and Impacts of Genetically Engineered Feedstuffs on Livestock Populations ," the review article is now available online in open-access form through the American Society of Animal Science. (wattagnet.com)
  • Therefore, proposed labeling of animal products from livestock and poultry that have eaten GE feed would require supply-chain segregation and traceability, as the products themselves would not differ in any way that could be detected. (wattagnet.com)
  • Five years later and we're still finding the same problems in test animals and livestock. (blogspot.com)
  • It includes background and specific provisions from the bill for each of the issues and options analyzed in the report: market competition and packer concentration, livestock mandatory price reporting, meat and poultry safety, country-of-origin labeling, animal identification for health protection, animal welfare, feed prices, disaster assistance, and environmental issues. (unt.edu)
  • GM livestock have been developed, although, as of November 2013 [update] , none were on the market. (wikipedia.org)
  • Detailed descriptions of methods used in animal cloning and biotechnology are provided in the report Animal Biotechnology: Science-Based Concerns (NRC, 2002). (nap.edu)
  • Application of recombinant bST is a biotechnology in which a recombinant-derived protein is administered by injection to the recipient animal without changing the animal's genetic composition or genome. (nap.edu)
  • Biotechnology also offers potential to animal agriculture as a means to reduce nutrients and odors from manure and volume of manure produced, resulting in animals that are more environmentally friendly (CAST, 2003). (nap.edu)
  • Areas in which biotechnology could be used to improve the welfare of animals while maintaining profitability are explored along with regulatory schema to improve agency integration in GE animal oversight. (springer.com)
  • In the spirit of my blog being a public forum, students in a first-year seminar course I taught this Fall (Animal Science 110S: Animal Biotechnology and Society) had to write a short blog about some aspect of biotechnology and agriculture. (feedburner.com)
  • In December 2003, the FDA said there was no reason for it to regulate the GloFish, a zebra danio fish genetically altered with fluorescent colors, because it was not intended for food and posed no environmental threat. (ibtimes.com)
  • CRISPR has prevented HIV infections in human cells and aided in the creation of genetically modified pigs that may one day serve as organ donors for human transplant patients. (ranker.com)
  • The pigs, whom had hastily recognized themselves as the intelligent leaders of their comrades, formulated the fundamentals of success on Animal Farm with a philosophy called Animalism. (bartleby.com)
  • Examples include transgenic pigs and sheep that have been genetically altered to express higher levels of growth hormone 9. (mint-body.com)
  • Some rare GM fish that escaped both captivity and the sterility or some other unpredicted event would have to happen. (ipscell.com)
  • If GM leads to human sterility in succeeding generations, would we like to see all beef products contaminated? (anh-usa.org)
  • As part of its charge, the committee was asked to prepare a subreport evaluating methods for detecting potential unintended compositional changes across the spectrum of messenger ribonucleic acid (mRNA), proteins, metabolites and nutrients that may occur in food derived from cloned animals that have not been genetically modified via genetic engineering methods. (nap.edu)
  • The process for getting government approval to sell food derived from genetically engineered animals appears to be a hopeless logjam. (latimes.com)
  • In the final chapter of the draft guidance document, recommendations are made for the post-market environmental monitoring (PMEM) of GM animals. (thefishsite.com)
  • Under EU legislation, applications for the authorisation of GM animals must contain a detailed PMEM plan which defines how potential unanticipated adverse effects on the environment will be monitored. (thefishsite.com)
  • The authors also thank Experimental Animal Centre of Fudan University and Shanghai Agrobiological Gene Center, especially Dr. Weiwei Qiao, Dr. Xianzhe Zhao, and Dr. Guolan Liu. (plos.org)
  • and the impact of the GM animal on human and animal health, for example to assess potential risks to farmers, other workers or the general public that may come into contact with GM animals. (thefishsite.com)
  • A new scientific review from the University of California, Davis, reports that the performance and health of food-producing animals consuming genetically engineered feed, first introduced 18 years ago, has been comparable to that of animals consuming non-GE feed. (wattagnet.com)
  • Transgenic biology provides a means of altering animal genomes to achieve desired production and health outcomes of commercial value and societal importance. (nap.edu)
  • I don't see any particular reason to think that this GM fish as a food would pose any significant health risks to people. (ipscell.com)
  • The US FDA stated that GM golden rice does not meet the nutritional requirements to make a health claim. (globalresearch.ca)
  • If that happens, we'll be closing the door on innovations that could help us face the public health and environmental threats of the future, saving countless animals, the article said - and perhaps ourselves. (nature.com)
  • Achievement of measurable health benefits with SDA in the diet as shown by Prof Harris has accelerated the entry of nutritionally enhanced GM soybeans into the consumer marketplace by several years. (biofortified.org)
  • You'll need to meet the animal health requirements of the country you are visiting. (usda.gov)
  • Genetic modification of an animal involves altering its genetic material by adding, changing or removing certain DNA sequences in a way that does not occur naturally. (europa.eu)
  • The advent of techniques to propagate animals by nuclear transfer, also known as cloning, potentially offers many important applications to animal agriculture, including reproducing highly desired elite sires and dams. (nap.edu)
  • Then they used cloning technology to create a female calf from the genetically modified cells. (latimes.com)
  • 4. Permits required in advance for all virus modifications, particularly where these viruses are being used to infect animal, plant or human cells. (globalchange.com)
  • Continued development of new biotechnologies also will allow farm animals to serve as sources of both biopharmaceuticals for human medicine and organs for transplantation. (nap.edu)
  • A Discussion That Companion Animals Have a Calculable Benefit to Human on a Diverse Scale. (mint-body.com)
  • The average orangutan is more diverse -- genetically speaking -- than the average human,' says lead author Devin Locke, PhD, an evolutionary geneticist at Washington University's Genome Center. (opposingviews.com)
  • Genentech announced the production of genetically engineered human insulin in 1978. (wikipedia.org)
  • Ruppy the Glowing Puppy is a little different - she's the world's first transgenic dog which means she produces 'a fluorescent protein that glows red under ultraviolet light ,' whereas most bioluminescent animals glow a blue or green when with UV light. (ranker.com)
  • If you live in Canada, you might soon be able to buy a genetically modified fluorescent houseplant that removes cancer-linked pollutants such as benzene from the air in your home. (newscientist.com)
  • To avoid international trade disruptions, it is critical that the regulatory approval process for genetically engineered products be established in countries importing these feeds at the same time that regulatory approvals are passed in the countries that are major exporters of animal feed," Van Eenennaam said. (wattagnet.com)
  • WASHINGTON (Reuters) - Genetically engineered animals moved closer to the dinner table on Thursday as the U.S. Food and Drug Administration made the process it will use to review new proposals public. (enn.com)