Animals, Congenic
Mice, Congenic
Chromosomes, Mammalian
Crosses, Genetic
Chromosome Mapping
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Rats, Inbred Dahl
Mice, Inbred NOD
Genetic Linkage
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Phenotype
Genetic Predisposition to Disease
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Genetic Markers
Alleles
Disease Susceptibility
Disease Models, Animal
Quantitative Trait, Heritable
Immunoglobulin Allotypes
Genotype
Histocompatibility Antigens
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Diabetes Mellitus, Type 1
A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Genes, MHC Class II
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Epistasis, Genetic
A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
Chromosomes
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Rats, Inbred SHR
Sialadenitis
Genetic Loci
Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
Rats, Inbred WKY
Immunity, Innate
Complement C5
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
Genes
AKR murine leukemia virus
Radiation Chimera
Autoimmune Diseases
Organogold Compounds
Mice, Transgenic
Haplotypes
Thymus Gland
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Dimercaprol
Lupus Erythematosus, Systemic
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Antigens, Ly
Rats, Inbred OLETF
Antigenic Modulation
Bone Marrow Transplantation
Mice, Inbred MRL lpr
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
Rats, Inbred BB
Hypertension
Lupus Nephritis
Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).
Chorioretinitis
Lymphocyte Activation
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Autoantibodies
Antigens, Thy-1
Genome
Microsatellite Repeats
Rats, Transgenic
Mice, 129 Strain
Radiation Hybrid Mapping
A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
Hybridization, Genetic
B-Lymphocytes
Telemetry
Body Weight
Gene Expression Regulation
Aminobiphenyl Compounds
Autoimmunity
Arthritis, Experimental
Antibody Formation
Gene Expression Profiling
Immune Tolerance
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Bone Marrow Cells
Rats, Inbred Strains
Friend murine leukemia virus
Leukemia Virus, Murine
Specific Pathogen-Free Organisms
Kidney
Lupus Vulgaris
Isoantigens
Antibodies, Antinuclear
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
Leukemia, Experimental
Recombination, Genetic
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Renin
Immunoglobulin G
Killer Cells, Natural
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
Heterozygote
Dinitrobenzenes
Arylamine N-Acetyltransferase
An enzyme that catalyzes the transfer of acetyl groups from ACETYL-COA to arylamines. It can also catalyze acetyl transfer between arylamines without COENZYME A and has a wide specificity for aromatic amines, including SEROTONIN. However, arylamine N-acetyltransferase should not be confused with the enzyme ARYLALKYLAMINE N-ACETYLTRANSFERASE which is also referred to as SEROTONIN ACETYLTRANSFERASE.
Mice, Inbred CFTR
A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.
Immunogenetics
Immunity, Cellular
Lymph Nodes
Mutation
Lod Score
Skin Transplantation
Sex Characteristics
Liver
CD4-Positive T-Lymphocytes
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
T-Lymphocyte Subsets
Macrophages
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Coombs Test
A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.
Antigens, CD45
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Adoptive Transfer
T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes. (1/252)
One of the diabetes susceptibility genes of the BB/W (Biobreeding/Worcester) rat maps to the lyp locus on chromosome 4. The BB/W lyp allele is responsible for a severe peripheral T lymphopenia. Correction of this lymphopenia by transfer of normal, histocompatible T cells prevents diabetes, providing T cell reconstitution is initiated before insulitis. We have analyzed this time-dependent regulation of the diabetogenic process by normal T cells. We demonstrate that T cell reconstitution after the initiation of insulitis precipitates the onset of diabetes through the recruitment of donor T cells to the autoimmune process. This inability of normal T cells to regulate primed diabetogenic BB/W T cells and their own autoreactive potential were observed when normal T cells outnumbered pathogenic T cells by approximately 1000-fold. Analysis of donor-derived T cells recovered from BB/W rats that were reconstituted before insulitis, and hence protected from diabetes, demonstrates that early T cell reconstitution of BB/W rats does not result in a long term physical or functional depletion of islet cell-specific T cell precursors among donor cells or in the expansion of T cells that can regulate the activation and expansion of diabetogenic T cells. (+info)Genetics of Cd36 and the clustering of multiple cardiovascular risk factors in spontaneous hypertension. (2/252)
Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension and in spontaneously hypertensive rats (SHRs). A deletion in the Cd36 gene on chromosome 4 has recently been implicated in defective carbohydrate and lipid metabolism in isolated adipocytes from SHRs. However, the role of Cd36 and chromosome 4 in the control of blood pressure and systemic cardiovascular risk factors in SHRs is unknown. In the SHR. BN-Il6/Npy congenic strain, we have found that transfer of a segment of chromosome 4 (including Cd36) from the Brown Norway (BN) rat onto the SHR background induces reductions in blood pressure and ameliorates dietary-induced glucose intolerance, hyperinsulinemia, and hypertriglyceridemia. These results demonstrate that a single chromosome region can influence a broad spectrum of cardiovascular risk factors involved in the hypertension metabolic syndrome. However, analysis of Cd36 genotypes in the SHR and stroke-prone SHR strains indicates that the deletion variant of Cd36 was not critical to the initial selection for hypertension in the SHR model. Thus, the ability of chromosome 4 to influence multiple cardiovascular risk factors, including hypertension, may depend on linkage of Cd36 to other genes trapped within the differential segment of the SHR. BN-Il6/Npy strain. (+info)Myelin oligodendrocyte glycoprotein induces experimental autoimmune encephalomyelitis in the "resistant" Brown Norway rat: disease susceptibility is determined by MHC and MHC-linked effects on the B cell response. (3/252)
Experimental autoimmune encephalomyelitis (EAE) induced by active immunization with the myelin oligodendrocyte glycoprotein (MOG) is an Ab-mediated, T cell-dependent autoimmune disease that replicates the inflammatory demyelinating pathology of multiple sclerosis. We report that disease susceptibility and severity are determined by MHC and MHC-linked effects on the MOG-specific B cell response that mediate severe clinical EAE in the EAE-resistant Brown Norway (BN) rat. Immunization with the extracellular domain of MOG in CFA induced fulminant clinical disease associated with widespread demyelination and with an inflammatory infiltrate containing large numbers of polymorphonuclear cells and eosinophils within 10 days of immunization. To analyze the effects of the MHC (RT1 system) we compared BN (RT1 n) rats with Lewis (LEW) (RT1 l) and two reciprocal MHC congenic strains, LEW.1N (RT1n) and BN.1L (RT1 l). This comparison revealed that disease severity and clinical course were strongly influenced by the MHC haplotype that modulated the pathogenic MOG-specific autoantibody response. The intra-MHC recombinant congenic strain LEW.1R38 demonstrated that gene loci located both within the centromeric segment of the MHC containing classical class I and class II genes and within the telomeric RT1.M region containing the MOG gene are involved in determining Ab production and disease susceptibility. This study indicates that the current T cell-centered interpretation of MHC-mediated effects on disease susceptibility must be reassessed in multiple sclerosis and other autoimmune diseases in which autoantibody is involved in disease pathogenesis. (+info)Pathological and immunological findings of athymic nude and congenic wild type BALB/c mice experimentally infected with Neospora caninum. (4/252)
Neospora is a cyst-forming coccidian parasite that causes abortions and neuromuscular disorders in a wide variety of mammals. Japanese bovine isolate JPA1 was inoculated intraperitoneally into BALB/c nu/ nu (athymic nude) and BALB/c (congenic wild type) female mice to examine the distribution of parasites and resistance mechanisms to Neospora infection. All the athymic nude mice died within 28 days after intraperitoneal injection of 2 x 10(5) JPA1 tachyzoites, whereas all the congenic wild type mice survived without exhibiting any clinical signs. Tachyzoites were identified in the uterus and pancreas and later spread to many other organs. Most tachyzoites identified in the necrotic foci were localized in the epithelium of the venules and capillaries. Nude mice developed high level of serum interferon-gamma and interleukin-6 as infection proceeded. Inflammatory response to Neospora infection might be mediated by Th1-type dependent cellular immunity. (+info)C6 produced by macrophages contributes to cardiac allograft rejection. (5/252)
The terminal components of complement C5b-C9 can cause significant injury to cardiac allografts. Using C6-deficient rats, we have found that the rejection of major histocompatibility (MHC) class I-incompatible PVG.R8 (RT1.A(a)B(u)) cardiac allografts by PVG.1U (RT1.A(u)B(u)) recipients is particularly dependent on C6. This model was selected to determine whether tissue injury results from C6 produced by macrophages, which are a conspicuous component of infiltrates in rejecting transplants. We demonstrated that high levels of C6 mRNA are expressed in isolated populations of macrophages. The relevance of macrophage-produced C6 to cardiac allograft injury was investigated by transplanting hearts from PVG. R8 (C6-) donors to PVG.1U (C6-) rats which had been reconstituted with bone marrow from PVG.1U (C6+) rats as the sole source of C6. Hearts grafted to hosts after C6 reconstitution by bone marrow transplantation underwent rejection characterized by deposition of IgG and complement on the vascular endothelium together with extensive intravascular aggregates of P-selectin-positive platelets. At the time of acute rejection, the cardiac allografts contained extensive perivascular and interstitial macrophage infiltrates. RT-PCR and in situ hybridization demonstrated high levels of C6 mRNA in the macrophage-laden transplants. C6 protein levels were also increased in the circulation during rejection. To determine the relative contribution to cardiac allograft rejection of the low levels of circulating C6 produced systemically by macrophages, C6 containing serum was passively transferred to PVG.1U (C6-) recipients of PVG.R8 (C6-) hearts. This reconstituted the C6 levels to about 3 to 6% of normal values, but failed to induce allograft rejection. In control PVG.1U (C6-) recipients that were reconstituted with bone marrow from PVG.1U (C6-) donors, C6 levels remained undetectable and PVG.R8 cardiac allografts were not rejected. These results indicate that C6 produced by macrophages can cause significant tissue damage. (+info)Congenic substitution mapping excludes Sa as a candidate gene locus for a blood pressure quantitative trait locus on rat chromosome 1. (6/252)
Previously, linkage analysis in several experimental crosses between hypertensive rat strains and their contrasting reference strains have identified a major quantitative trait locus (QTL) for blood pressure on rat chromosome 1 (Chr 1) spanning the Sa gene locus. In this study, we report the further dissection of this Chr 1 blood pressure QTL with congenic substitution mapping. To address whether the Sa gene represents a candidate gene for the Chr 1 blood pressure QTL, congenic strains were developed by introgressing high blood pressure QTL alleles from the stroke-prone spontaneously hypertensive rat (SHRSP) into the normotensive Wistar-Kyoto (WKY-1) reference strain. Congenic animals carrying a chromosomal segment from stroke-prone spontaneously hypertensive rats between genetic markers Mt1pa and D1Rat200 (including the Sa gene locus) show a significant increase in basal systolic and diastolic blood pressure compared with their normotensive Wistar-Kyoto progenitors (P<0.001, respectively), whereas congenic animals carrying a subfragment of this Chr 1 region defined by markers Mt1pa and D1Rat57 (also spanning the Sa gene) do not show elevated basal blood pressure levels (P=0.83 and P=0.9, respectively). Similar results were obtained for NaCl-induced blood pressure values. Thus, the blood pressure QTL on Chr 1 is located centromeric to the Sa gene locus in a region that is syntenic to human chromosome 11p15.4-p15.3. This region excludes the Sa as a blood pressure-elevating candidate gene locus on the basis of congenic substitution mapping approaches. (+info)Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. (7/252)
A CD4(+) T cell subpopulation defined by the expression levels of a particular cell surface molecule (e.g. CD5, CD45RB, CD25, CD62L or CD38) bears an autoimmune-preventive activity in various animal models. Here we show that the expression of CD25 is highly specific, when compared with other molecules, in delineating the autoimmune-preventive immunoregulatory CD4(+) T cell population. Furthermore, although CD25 is an activation marker for T cells, the following findings indicate that immunoregulatory CD25(+)CD4(+) T cells are functionally distinct from activated or anergy-induced T cells derived from CD25(-)CD4(+) T cells. First, the former are autoimmune-preventive in vivo, naturally unresponsive (anergic) to TCR stimulation in vitro and, upon TCR stimulation, able to suppress the activation/proliferation of other T cells, whereas the latter scarcely exhibit the in vivo autoimmune-preventive activity or the in vitro suppressive activity. Second, such activated or anergy-induced CD25(-) spleen cells produce various autoimmune diseases when transferred to syngeneic athymic nude mice, whereas similarly treated normal spleen cells, which include CD25(+)CD4(+) T cells, do not. Third, upon polyclonal T cell stimulation, CD25(+)CD4(+) T cells express CD25 at higher levels and more persistently than CD25(-)CD4(+) T cell-derived activated T cells; moreover, when the stimulation is ceased, the former revert to the original levels of CD25 expression, whereas the latter lose the expression. These results collectively indicate that naturally anergic and suppressive CD25(+)CD4(+) T cells present in normal naive mice are functionally and phenotypically stable, distinct from other T cells, and play a key role in maintaining immunologic self-tolerance. (+info)Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. (8/252)
Genetic analysis of the diabetic GK rat has revealed several diabetes susceptibility loci. Congenic strains have been established for the major diabetes locus, Niddm1, by transfer of GK alleles onto the genome of the normoglycemic F344 rat. Niddm1 was dissected into two subloci, physically separated in the congenic strains Niddm1b and Niddm1i, each with at least one disease susceptibility gene. Here we have mapped Niddm1b to 1 cM by genetic and pathophysiological characterization of new congenic substrains for the locus. The gene encoding insulin-degrading enzyme (IDE:) was located to this 1 cM region, and the two amino acid substitutions (H18R and A890V) identified in the GK allele reduced insulin-degrading activity by 31% in transfected cells. However, when the H18R and A890V variants were studied separately, no effects were observed, demonstrating a synergistic effect of the two variants on insulin degradation. No effect on insulin degradation was observed in cell lysates, indicating that the effect is coupled to receptor-mediated internalization of insulin. Congenic rats with the IDE: GK allele displayed post-prandial hyperglycemia, reduced lipogenesis in fat cells, blunted insulin-stimulated glucose transmembrane uptake and reduced insulin degradation in isolated muscle. Analysis of additional rat strains demonstrated that the dysfunctional IDE: allele was unique to GK. These data point to an important role for IDE: in the diabetic phenotype in GK. (+info)
Infection of Inbred Rat Strains with Rift Valley Fever Virus: Development of a Congenic Resistant Strain and Observations on...
Physical Confirmation and Comparative Genomics of the Rat Mammary carcinoma susceptibility 3 Quantitative Trait Locus | G3:...
Kidney Specificity of Rat Chromosome 1 Blood Pressure Quantitative Trait Locus Region | Hypertension
E-GEOD-30770 - Impaired endosomal recycling in proximal tubules is mechanistically linked to proteinuria - OmicsDI
18th International Mouse Genome Conference (2004)
Subcongenic Analyses Reveal Complex Interactions between Distal Chromo by Jessica Stolp, Yi-Guang Chen et al.
Gene-environment interaction: a significant diet-dependent obesity lo by B York, A A. Truett et al.
Speed congenics | APF
Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome. - Radcliffe...
Localization of a Na|sup|+|/sup|, K|sup|+|/sup|-ATPase α 2 subunit gene, Atp1a2, on rat Chromosome 13 - Fingerprint -...
BP16 Gene - GeneCards | BP16 Genetic Locus
congenic
The 16th International Mouse Genome Conference (2002)
Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies...
romiguier jonathan | la Recherche
NA11827
NA10836
Congenic Mapping and Sequence Analysis of the Renin LocusNovelty and Significance | Hypertension
Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression...
Molecular cloning and sequence analysis of mutant alleles of the fission yeast cdc2 protein kinase gene: implications for cdc2+...
Plus it
OpenVPN: buffer Struct Reference
The Cystatin S gene maps to rat Chromosome 3, to which D1mgh18 is re-assigned from Chromosome 1<...
MySQL Lists: commits: bzr commit into mysql-trunk-innodb branch (inaam.rana:3387)
Interval-specific congenic strains (ISCS): An experimental design for mapping a QTL into a 1-centimorgan interval | SpringerLink
MySQL Lists: commits: bzr commit into mysql-5.1-innodb branch (marko.makela:3458) Bug#53307
Plus it
rat chromosome paints
002089 - AK.B6-H2|b| Fv1|b|/J
RBRC01518, D2;B6CB-Trp53|tm1Sia|/TyagRbrc - Animal Search System
RBRC01348
Biostatistics Software Download
Comportamento redox e detecção voltamétrica de neurotransmissores, nitrito, derivados...
Lirias: Transport in multiterminal normal-superconductor devices: Reciprocity relations, negative and nonlocal resistances, and...
2016 - Volume 17 [Issue 8]
| Journal of Advances in Medicine and Medical Research
Fine mapping of quantitative trait loci using selected overlapping recombinant chromosomes, in an interspecies cross of tomato....
Detection of arthritis-susceptibility loci, including Ncf1, and variable effects of the major histocompatibility complex region...
Association between leptin level and renal cell carcinoma susceptibility and progression: A meta-analysis
Improved Buffer Pool Scalability
A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density, Mammalian Genome | 10.1007/s00335-001...
Increased physical activity cosegregates with higher intake of carbohydrate and total calories in a subcongenic mouse strain,...
DA rats from two colonies differ genetically and in their arthritis susceptibility
Transgenic Genotyping Services
AppFS: Artifact Content
FFmpeg-devel] [PATCH] dvbsubdec: check against buffer overreads
BNX2]: Fix bug in bnx2 nvram write().
Pengaman rumah Via HP Siemens c45 | DEATRONIK.COM KAMI HADIR KARENA ANDA
Para RNO 10 microtubes
The Machine Perception Toolbox (MPT)
22742 (torspec should say when tors event buffer limit was removed)
- Tor Bug Tracker & Wiki
PATCH v2 1/3] kernel32/tests: Fix GetLastError() checks in environment tests.
Ask the Expert with Lew Schon, MD
Taconic Biosciences
"Caliper sells animal models subsidiary to Taconic Farms for $11 million". Drug Discovery News. Retrieved 13 December 2009. v t ... 1994 - Contracted with National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and ... "Taconic Biosciences , Lab Animal Buyers' Guide". Guide.labanimal.com. Retrieved 2017-05-22. "Nancy J. Sandy Appointed Chief ... Taconic Biosciences is a breeder and supplier of laboratory animals operating in over 50 countries. The current CEO is Nancy J ...
Inbreeding
... a consistent and uniform animal model for experimental purposes and enables genetic studies in congenic and knock-out animals. ... Small animals such as cats and dogs may be sterilized, but in the case of large agricultural animals, such as cattle, culling ... However, in species such as horses, animals in wild or feral conditions often drive off the young of both sexes, thought to be ... Animals avoid incest only rarely. Inbreeding results in homozygosity, which can increase the chances of offspring being ...
List of MeSH codes (B01)
... animals, congenic MeSH B01.050.199.040.500 - mice, congenic MeSH B01.050.199.520 - animals, inbred strains MeSH B01.050.199.520 ... MeSH B01.050.157.040 - animals, congenic MeSH B01.050.157.040.500 - mice, congenic MeSH B01.050.157.520 - mice, inbred strains ... animals, congenic MeSH B01.050.199.520.040.500 - mice, congenic MeSH B01.050.199.520.520 - mice, inbred strains MeSH B01.050. ... congenic MeSH B01.150.900.649.865.635.505.500.400 - mice, inbred strains MeSH B01.150.900.649.865.635.505.500.400.300 - mice, ...
Passive immunity
Patients who are immunized with the antibodies from animals may develop serum sickness due to the proteins from the immune ... "congenic", or deliberately inbred mouse strains which are histocompatible. An individual's immune response of passive immunity ... Shibasaburo and von Behring immunized guinea pigs with the blood products from animals that had recovered from diphtheria and ... If a neonatal animal does not receive adequate amounts of colostrum prior to gut closure, it does not have a sufficient amount ...
Hebb-Williams maze
In general, animals are tested in the Hebb-Williams maze's twelve separate mazes after acclimating to six practice mazes, ... Stanford, Lianne; Brown, Richard E. (September 2003). "MHC-congenic mice (C57BL/6J and B6-H-2K) show differences in speed but ... The Hebb-Williams maze is a maze used in comparative psychology to assess the cognitive ability of small animals such as mice ... This modified version is the most commonly used in research where the aim is to measure animals' problem-solving abilities. ...
Behavioral neuroscience
Normally this is performed with sedated animals but sometimes it is performed on awake animals engaged in a behavioral event, ... Selective breeding - Organisms, often mice, may be bred selectively among inbred strains to create a recombinant congenic ... Single-unit recording - A method whereby an electrode is introduced into the brain of a living animal to detect electrical ... René Descartes proposed physical models to explain animal as well as human behavior. Descartes suggested that the pineal gland ...
Rat Genome Database
For congenic and mutant strains, genomic positions are assigned for the introgressed region (congenic strains) or the location ... Autism Models: Laboratory rats are the animal of choice in neurobiology. The Medical College of Wisconsin has been working with ... Such sequences are useful primarily for researchers still using these markers for genotyping their animals and for ... cells and molecular pathways at the whole animal or systems level. Until recently, direct, specific genomic manipulations in ...
NOD mice
Non-obese diabetic or NOD mice, like biobreeding rats, are used as an animal model for type 1 diabetes. Diabetes develops in ... Loci associated with susceptibility to IDDM have been identified in the NOD mouse strain through the development of congenic ... Fox, James; Anderson, Lynn; Otto, Glen; Corning, Kathleen; Whary, Mark (2015). Laboratory Animal Medicine (3 ed.). Amsterdam: ... Portals: Animals Biology (Laboratory mouse strains, Diabetes, Population genetics). ...
Influenza A virus subtype H7N9
They believe that live bird markets may play a key role in human and animal infections with H7N9 and that, even if the overall ... the national avian flu reference laboratory concluded that the strain of the H7N9 virus found on pigeons was highly congenic ... It will also be important to verify whether the H7N9 virus is transmissible from humans to animals because if established, it ... Activation was prompted because the novel H7N9 avian influenza virus has never been seen before in animals or humans and ...
Inbred strain
... s (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which ... Backcrossing Congenic strain Inbreeding Linebreeding Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MF, ... Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all ... Thus outbred strains of most laboratory animals are also available, where an outbred strain is a strain of an organism that is ...
Mate choice
In other words, before an animal engages with a potential mate, they first evaluate various aspects of that mate which are ... Evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types". Journal ... The genetic diversity of animals and life reproductive success (LRS) at the MHC level is optimal at intermediate levels rather ... Similar to the humans of the odor-rating experiment, animals also choose mates based upon genetic compatibility as determined ...
Mate choice in humans
Unlike many animals, humans are not able to consciously display physical changes to their body when they are ready to mate, so ... Evidence from the use of a Y-maze differentially scented by congenic mice of different major histocompatibility types". Journal ... Relative to most other animals however, female and male mating strategies are found to be more similar to each other. According ... ISBN 978-0-333-72558-0.[page needed] Collins, Sarah A. (2000). "Men's voices and women's choices". Animal Behaviour. 60 (6): ...
Jan Klein
He defined immunology as the science of self-nonself discrimination, concerned not just with the human species and its animal ... The associations were demonstrated by testing the responses of congenic strains differing at the H2 complex and mapping the ... background and thus producing a set of congenic B10.W lines. These lines proved to be essential for the complete ...
Borrelia lusitaniae
1995). "T cell response to Borrelia garinii, Borrelia afzelii, and Borrelia japonica in various congenic mouse strains". ... nymphs that feed on long-distance migrants give rise to hunting adult ticks that subsequently feed on larger animals, such as ...
Bone marrow adipose tissue
November 2004). "Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered ... it is difficult to employ in laboratory animals. Magnetic resonance imaging (MRI) provides BMAT assessment in the vertebral ...
DeCS - Termos Novos
Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran...
All strains were BALB/c-congenic and were maintained as homozygous colonies or by continuous backcrossing to BALB/c animals. ... Animal studies. Female Balb/c mice were maintained according to the Australian Standards for Animal Care under the protocols ... The animals with one wild-type copy of the Flii gene and one mutant copy of the Flii gene express no more than 50% of the ... The University of Adelaide Animal Ethics Committee and University of South Australia Animal Ethics Committee (AEC 962/12/16 and ...
Contents: Neurobiology of Alcohol Dependence: Focu
5xFAD (C57BL6) | ALZFORUM
Compared with hemizygous 5xFAD mice, animals homozygous for the transgenes exhibit more severe amyloid pathology; behavioral ... and have since generated their own congenic lines through backcrossing. 5xFAD mice on a C57BL/6J background are commercially ... Human APP was detected by immunohistochemistry in subicular and layer V pyramidal neurons in animals as young as 16 days, and ... and thalamus of 2-month animals (Richard et al., 2015). Intraneuronal Aβ and extracellular plaques were also observed in spinal ...
Strain Report - Rat Genome Database
... when the donor genome outside of the congenic segment was removed, two heterozygous animals were intercrossed to produce ... Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 ... DA/ZtmKini females were mated with BN/Rj males, speed congenic strategy was used to generate these congenics; ...
Frontiers | The Non-Obese Diabetic Mouse Strain as a Model to Study CD8+ T Cell Function in Relapsing and Progressive Multiple...
immunized a series of congenic NOD mice carrying B6-derived Idd loci with MOG[35-55] (60). They found that NOD mice carrying B6 ... Several decades worth of evidence from animal models have supported the idea that CD4+ T cells are the chief drivers of ... Animal Models of MS. Experimental autoimmune encephalomyelitis is a murine disease that recapitulates the immunopathogenesis of ... Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. Immunity (2001) 15:387-95. doi: ...
JCI Insight -
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity
5 × 106 CD8+ T cells were injected i.v. into wild-type recipient animals (C57BL/6). At day 5 or day 35 after transfer, mice ... Transferred cells were identified by the congenic marker CD45.1 while endogenous cells were CD45.2. (E) MFI (mean ± SEM) of ... cells from an animal receiving NAC-treated CD8+ T cells. Endogenous host CD8+ T cells are shown as a control. Data refer to day ... followed by ACT in wild-type animals. At day 35 after transfer, we recovered a higher frequency of Tn-like cells (i.e., CD62Lhi ...
2nd Congress of the Slovenian Society for Laboratory Animals, Ljubljana 2014 - VideoLectures - VideoLectures.NET
Protein digestibility and bioavailability of the F2 homozygous crossing line of the congenic mice for the lean locus Fob3b2, ... Micro and macro environment in rodents animal facilitiesMicro and macro environment in rodents animal facilities. ... Helping the public to understand animal researchHelping the public to understand animal research. ... Event: Conferences » Other » 2nd Congress of the Slovenian Society for Laboratory Animals, Ljubljana 2014 2nd Congress of the ...
A novel role for lipoxin A4 in driving a lymph node-eye axis that controls autoimmunity to the neuroretina | eLife
Animal experimentation: All experimental procedures were approved by the Animal Care and Use program at University of ... IRBP-specific TCR transgenic R161H mice (Horai et al., 2013) generated on the congenic CD90.1 B10.RIII background and WT CD90.2 ... and are in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals. All animals were ... All animals were maintained on the NIH-31 Open Formula diet with 1.9% C18:2 ω6 linoleic acid and 0.2% C18:3 ω3 linolenic acid ( ...
Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats - MDC Repository
Adducin, Congenic Strains, Genetics, Hypertension, Inbred MHS, Animals, Rats. Source:. Biochemical and Biophysical Research ... Congenic strains were developed by introgressing Add1, Add2, and Add3 genes (and chr14, chr4, and chr1 associated segments) of ... In this study, we report the dissection of the individual contribution of each rat Add gene to blood pressure, by congenic ... In contrast, SBPs of Add2 and Add3 congenic strains were not different from those of the correspondent recipient parental ...
NIOSHTIC-2 Search Results - Full View
Recently, Johnson has developed two relevant congenic mouse strains. In the congenic C57BL/6J strain, the Ahl locus has been ... Laboratory-animals; Animals; Molecular-structure; Genetics; Genetic-factors ... This presentation will compare ABR results in the two congenic strains as well as compare the present data with the previous ... This would be expected based on the fact that the congenic CBA.B6 mice genotypes included the mutant Ahl locus. ...
Pathophysiology and treatment of defective insulin secretion in diabetes | Lund University Publications
In a specifically designed congenic animal model of defective insulin secretion, we were able to identify two genetic loci on ... In a specifically designed congenic animal model of defective insulin secretion, we were able to identify two genetic loci on ... In a specifically designed congenic animal model of defective insulin secretion, we were able to identify two genetic loci on ...
Hematopoietic MicroRNA-126 Protects against Renal Ischemia/Reperfusion Injury by Promoting Vascular Integrity | American...
LV-126 animals demonstrated a significantly higher vessel surface area compared with LV-C animals. (E) Total surface area of ... FACS analysis for the expression ratios between congenic markers CD45.1 (donor) and CD45.2 (acceptor) in PB and BM of the ... The animal welfare committee of the Leiden University Medical Center approved all animal experimental protocols. ... cells in animals transplanted with LV-C or LC-126 compared with cells of nontransplanted animals (donor). (B) Representative ...
NIOSHTIC-2 Search Results - Full View
Recently, Johnson has developed two relevant congenic mouse strains. In the congenic C57BL/6J strain, the Ahl locus has been ... Laboratory-animals; Animals; Molecular-structure; Genetics; Genetic-factors ... This presentation will compare ABR results in the two congenic strains as well as compare the present data with the previous ... The present study was designed to test these congenic strains for their vulnerability to noise-induced hearing loss. Mouse ...
Endogenous MMTV Proviruses Induce Susceptibility to Both Viral and Bacterial Pathogens
DeCS - Termos Novos
DeCS - New Terms
DeCS - Termos Novos
DeCS - Términos Nuevos
DeCS - New Terms
DeCS - Términos Nuevos
DeCS - New Terms
DeCS - Termos Novos
DeCS - New Terms
DeCS - New Terms
DeCS - Términos Nuevos
DeCS - Termos Novos
DeCS - Términos Nuevos
DeCS - New Terms
Inbred strains4
- The creation of double congenic inbred strains for the study of two genetic polymorphisms was also addressed. (cdc.gov)
- Recombinant congenic inbred strains involved the separation of the unlinked components of a multigene trait into inbred strains. (cdc.gov)
- Our genetic platform is based on the use of genetically diverse mouse inbred strains, recombinant congenic strains, and experimentally induced mutagenized mouse stocks (ENU mutants). (mcgill.ca)
- The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. (mmrrc.org)
MICE20
- However, many laboratories preferred to use mice on a C57BL6 background, and have since generated their own congenic lines through backcrossing. (alzforum.org)
- This would be expected based on the fact that the congenic CBA.B6 mice genotypes included the mutant Ahl locus. (cdc.gov)
- A BALB/c congenic mouse strain lacking all endogenous Mtvs (Mtv-null) was resistant to MMTV oral and intraperitoneal infection and tumorigenesis compared to wild-type BALB/c mice. (utexas.edu)
- One approach involves the experimental transmission of disease by inoculating homogenized brain tissue from affected animals into transgenic mice that are overexpressing 1 of the 2 common polymorphic forms of the human PrP (either methionine or valine at residue 129) on a mouse PrP null background ( 16 ). (cdc.gov)
- We have previously shown that in IgH congenic mice VH-gene family usage in neonatal spleen B cells and adult Ig-secreting cells is entirely determined by the IgH locus, while in adult resting B cells it is regulated by genetic element(s) located outside the IgH locus. (pasteur.fr)
- METHODS: Congenic C1qa mice were generated in the DBA/2NNia background. (bvsalud.org)
- Female and male knockout (-/-), heterozygous (+/-), and wild type (+/+) mice were aged up to 14 months and IOPs were recorded in a subset of animals. (bvsalud.org)
- As opposed to monolayers prepared from the A and C3H background animals, monolayers from B10 background mice only demonstrated an H-2 haplotype dependent rate differential after treatment with fetal calf serum or neuraminidase. (rupress.org)
- Severe combined immunodeficient (SCID) mice and their congenic strain CB17 were purchased from M&B (Bomholtvej, Denmark). (biomedcentral.com)
- All mice were housed in the animal facility of the Department of Rheumatology, University of Göteborg. (biomedcentral.com)
- To examine whether genetic background influenced the phenotype in the piebald mutant mice, we generated a congenic strain (B6.PROD-s/s), produced by repeated backcrosses to the C57BL/6J (B6) strain. (elsevier.com)
- Although much of this research is done directly in the livestock animal of interest, some animal health research is done using surrogate models, such as mice. (taconic.com)
- With so many well-understood mouse disease models, and the commercial availability of germ-free mice which can be associated with a defined microbiota, we expect murine studies to be critical tools supporting the development of livestock and companion animal probiotics. (taconic.com)
- Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice after platelet rich plasma (PRP)/embryonic fibroblast transplantation. (rejenevie.com)
- Primary adipose derived stem cells (ADSCs) and bone marrow derived stem cells (BMSCs) were harvested from young and aged mice, and found that cell senescence was strongly correlated to animal aging. (rejenevie.com)
- For immunizations, WT donor T cells were transferred into Balb/c mice and, 24 h later, these were intravenously injected with 1-2 × 105 congenic, buy Rapamycin bone marrow-derived dendritic cells (BM-DCs) that were preactivated with LPS and loaded with Ova peptide (1 μg/mL each). (rafinhibitors.com)
- These animals can be used to study gene function, gene expression, gene regulation, to develop animal models of human disease, to test gene therapy reagents, to establish cell lines from specific cell types transformed in vivo, to produce mice with tissue-specific inducible gene expression or tissue-specific gene deletions, or to study the effects of cell specific ablation with toxigenes. (umich.edu)
- The Transgenic Core derives specific pathogen free mice or rats from pathogen infected animals. (umich.edu)
- Any project that uses mice must be approved by the Institutional Animal Care & Use Committee (IACUC) . (umich.edu)
- Some of the mice Chervonsky and Golovkina used in their experiments were congenic, or genetically the same except for differences in part of the genome called the major histocompatibility locus (MHC), which determines adaptive immunity. (uchicagomedicine.org)
Strain5
- In contrast, SBPs of Add2 and Add3 congenic strains were not different from those of the correspondent recipient parental strain. (mdc-berlin.de)
- In the congenic C57BL/6J strain, the Ahl locus has been replaced by the wild-type locus from the inbred CBA/CaJ strain (strain B6.CBA). (cdc.gov)
- In the congenic CBA/CaJ strain the wild-type locus has been replaced by the mutant Ahl locus (strain CBA.B6). (cdc.gov)
- 2003 Hum Mol Genet 12:2949) compares the well characterized B6-R1.40 strain with two additional congenic strains, D2-R1.40 and 129S1-R1.40. (mmrrc.org)
- Congenic strains in which the iP chromosome 4 QTL interval was transferred to the iNP (NP.P) exhibited the expected increase in alcohol consumption compared with the iNP background strain. (geneweaver.org)
C57BL2
Genetically1
- The Custom Strains department provides breeding and maintenance of customer-owned rodent strains, including inbred, hybrid, congenic and genetically modified strains. (wa.gov.au)
Rats2
- Using Ian5 congenic inbred rats (wild-type (non-lyp BB) and mutated (BB)), we assessed the development of BB regulatory CD8 − 4 + 25 + T cells and their role in the pathogenesis of DM. (aai.org)
- New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. (mcw.edu)
Locus1
- Two observations reported here demonstrate that the differential expression of VH genes is an intrinsic property of the respective cell populations, determined by both the IgH locus and by a cis element(s) operating independently in the same animal. (pasteur.fr)
Genetics1
- Humans began applying knowledge of genetics in prehistory with the domestication and breeding of plants and animals. (wikipedia.org)
Autoimmunity1
- Autoimmune mechanisms are pathogenic in experimental and spontaneous animal models associated with the development of autoimmunity. (biologyjunction.com)
Gene Expression2
- In chimeras of IgH congenic donors, VH-gene expression in fetal liver-derived splenic B cells and Ig-secreting cells is dictated by the IgH haplotype, while in bone marrow-derived B cells is entirely determined by the cis element(s). (pasteur.fr)
- CONCLUSIONS: Cis-regulated candidate genes for alcohol consumption were identified using microarray profiling of gene expression differences in congenic animals carrying a QTL for alcohol preference. (geneweaver.org)
Mutant1
- The MSM-Wv and MSM-Tyrc strains are MSM-background congenic strains carrying mutant alleles within lab strains. (cancer-ecosystem.com)
Segment1
- The fine mapping of chr14 congenic segment supports the identity of blood pressure QTL with Add1 gene. (mdc-berlin.de)
Embryonic1
- The relationship that was seen between monolayer H-2 haplotype and rate of adhesion with embryonic monolayers was not observed with either congenic 3T3 cell lines or fibroblasts derived from adult tissues. (rupress.org)
Experiments3
- The use of these animals permits reproducibility and consistency across experiments in order to make definitive observations and interpretations that cannot be attributed to genetic variation. (iqbiosciences.com)
- Thus proper in vivo experiments are required to establish the safety and efficacy of new animal health probiotics 2 . (taconic.com)
- Animals were maintained in pathogen-free housing and experiments were carried out in accordance to federal, state, and institutional guidelines. (rafinhibitors.com)
Humans4
- Over the past 2 decades, surrogate methods have been developed to assess the relative pathogenicity of animal prions for humans. (cdc.gov)
- Farmers routinely treat livestock with low-dose antibiotics to promote growth, but that practice has been widely criticized as leading to the development of antimicrobial resistance, which the US Department of Agriculture has called " one of the most serious health threats to both animals and humans . (taconic.com)
- ethylene Monographs , a review was undertak icals and other agents that may oxide (in 1994), based on strong ev en during 2008-2009 of relevant in pre sent carcinogenic hazards to idence of genotoxicity and limited formation on all the agents classified humans. (who.int)
- The car between humans and experimental have also been shown to cause cinogens evaluated in Volume animals, and of mechanistic events cancer in animals. (who.int)
Traits1
- These findings do not only underscore the utility of the congenic and subcongenic approach in differentially analyzing complex traits, but also show that candidate genes can be identified and that chromosomal exchange can variously influence the phenotype, leading to sub-phenotypes which may be representative for human beings. (uni-greifswald.de)
Genes5
- Congenic strains were developed by introgressing Add1, Add2, and Add3 genes (and chr14, chr4, and chr1 associated segments) of MHS in the Milan normotensive rat (MNS) genetic background (MNS.H-Add1, MNS.H-Add2, and MNS.H-Add3) and vice versa (MHS.N-Add1, MHS.N-Add2, and MHS.N-Add3). (mdc-berlin.de)
- Identification of candidate genes for alcohol preference by expression profiling of congenic rat strains. (geneweaver.org)
- This study was undertaken to identify genes in the chromosome 4 QTL interval that might contribute to the differences in alcohol consumption between the alcohol-naïve congenic and background strains. (geneweaver.org)
- To increase the power to detect differentially expressed genes, combined analyses (averaging data from the 5 discrete brain regions of each animal) were also carried out. (geneweaver.org)
- Therefore, we developed new animal models of obesity to search for diabetogenic genes associated with obesity. (mcw.edu)
Analyses1
- In histological analyses, aganglionosis was detected in the rectum of megacolon animals. (elsevier.com)
Genetic4
- In a specifically designed congenic animal model of defective insulin secretion, we were able to identify two genetic loci on rat chromosome 1 that confer impaired beta-cell glucose metabolism and. (lu.se)
- While these three congenic strains have similar levels of holo-APP in brain tissue, the levels of brain APP C-terminal fragments (CTFs) vary depending upon genetic background. (mmrrc.org)
- Moreover, an alternative to the genetic differential analysis of complex mammalian diseases is the use of animal models. (uni-greifswald.de)
- The availability of inbred animal models closely resembling the human disease is an essential component of genetic investigations in this field, as shown in the results of this work. (uni-greifswald.de)
Susceptibility1
- Susceptibility to noise -induced hearing loss in two congenic mouse strains. (cdc.gov)
Mouse2
- Recently, Johnson has developed two relevant congenic mouse strains. (cdc.gov)
- When scientists transfer microbes from one mouse to another, the result is largely determined by the microbiome of the source animal, what kind of food they eat, where they live, etc. (uchicagomedicine.org)
Antibodies1
- Resistance to MMTV in Mtv-null animals was not due to neutralizing antibodies. (utexas.edu)
Spontaneous2
Models5
- A discussion of the application of animal models to the study of the effects of heredity on the human response to chemicals was presented in this paper. (cdc.gov)
- The authors conclude that animal models are extremely helpful in the study of the human response to chemicals. (cdc.gov)
- Animal Models of Atrial Fibrillation. (harvard.edu)
- Experimental data indicate that α and β adducin are expressed into the glomerulus and their polymorphisms are involved in the altered expression of some podocyte proteins, proteinuria and progression of renal damage in animal models independently from their blood pressure. (justia.com)
- 100 of the IARC Monographs at different sites in separate ani en the scientific value of Volume confirm that the induction of mal models. (who.int)
Severe1
- Microcapillary leakage was seen to increase with age in both 5xFAD and wild-type brains, but was more severe in the transgenic animals. (alzforum.org)
Experimental1
- 100, and embarked on a twophase cancer in experimental animals 4. (who.int)
Mechanisms1
- Animals have two primary types of immunity: innate, or inborn, immunity that uses standard, hardwired mechanisms to fend off pathogens, and adaptive immunity that "learns" as it encounters different pathogens and uses T cells and B cells to target their unique receptors. (uchicagomedicine.org)
Exposure3
- Public and animal health controls to limit human exposure to animal prions are focused on bovine spongiform encephalopathy (BSE), but other prion strains in ruminants may also have zoonotic potential. (cdc.gov)
- Although atypical scrapie has been discovered retrospectively in 2 UK sheep culled in 1987 and 1989 ( 14 , 15 ), the level and duration of human exposure to atypical scrapie prions are unknown, and this lack of knowledge confounds a cause-and-effect investigation of epidemiologic links between this animal disease and some form of CJD ( 11 ). (cdc.gov)
- Atopy as a Modifier of the Relationships Between Endotoxin Exposure and Symptoms Among Laboratory Animal Workers. (harvard.edu)
Arthritis1
- Histomorphological analysis of the joints with respect to inflammatory cell infiltration, pannus formation and erosion formation revealed development of arthritis in 80% of animals injected with TF. (biomedcentral.com)
Research4
- But did you know that microbiome research and probiotics are also of interest to the animal health and agriculture markets? (taconic.com)
- This includes both scientific materials, such as DNA samples and genotyping tests, and paperwork, such as approval to use animals in research, material transfer agreements and billing information. (umich.edu)
- Contact the Animal Care & Use Office for information on how to apply for permission to use vertebrate animals in research, testing, or teaching. (umich.edu)
- Investigators approved for animal research are expected to provide ULAM with a shortcode that can be used to pay for veterinary care and husbandry/housing costs. (umich.edu)
Equine1
- Demand extends beyond the livestock market to companion animals and the equine industry. (taconic.com)
Vitro1
- Properly controlled development of new probiotics for animal health should include a series of in vitro selection steps followed by in vivo efficacy assessment. (taconic.com)
Laboratory6
- Animals, Laboratory" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Animals, Laboratory" by people in Harvard Catalyst Profiles by year, and whether "Animals, Laboratory" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Animals, Laboratory" by people in Profiles. (harvard.edu)
- Examining the effects of psychoactive drugs on complex behavioral processes in laboratory animals. (harvard.edu)
- The Unit for Laboratory Animal Medicine (ULAM) provides animal housing and veterinary care to all animals on campus. (umich.edu)
- neutron radiation (in cinogenicity in laboratory animals. (who.int)
Study4
- In this study, we report the dissection of the individual contribution of each rat Add gene to blood pressure, by congenic substitution mapping. (mdc-berlin.de)
- First, the study of F1 hybrids between the IgH congenic B6a and CB.20 strains demonstrates that cis elements control VH-gene family expression. (pasteur.fr)
- The aim of this study is to investigate the potential of PRP for recovering cellular potential from senescence and then delaying animal aging. (rejenevie.com)
- Furthermore, it will also be possible to locate the syntenic region in the human genome and congenic and subcongenic strains can also be used to study interactions between chromosomal regions and various selected environmental conditions. (uni-greifswald.de)
Test2
- Pairing two animals in parabiosis to test for systemic or circulatory factors from one animal affecting the other animal has been used in scientific studies for at least 150 years. (rejenevie.com)
- A variation on the technique, heterochronic parabiosis, whereby two animals of different ages are joined to test for systemic regulators of aspects of aging or age-related diseases also has almost a century-long scientific history. (rejenevie.com)
Health1
- This clinical trial was registered at the Iranian Registry of Clinical Trials (IRCT) with the identifier IRCT ID: IRCT2016070428786N1 registered on August 20, 2016 (Retrospectively registered) ( https://en.irct.ir/trial/23256 ) and at the U.S. National Institutes of Health (ClinicalTrials.gov) with the related identifier NCT04078308 registered on September 6, 2019 (Retrospectively registered). (biomedcentral.com)
Young1
- Increased mortality is observed in young animals. (mmrrc.org)