Animal Use Alternatives

Animal Testing Alternatives

Animal Welfare

Animal Experimentation

Animals, Laboratory

Animal Care Committees

Toxicity Tests

Alternatives to animal testing

Center for Alternatives to Animal Testing

Canadian Centre for Alternatives to Animal Methods

European Partnership for Alternative Approaches to Animal Testing

Potentially all pairwise rankings of all possible alternatives

Alternative mating strategy

Alternative medicine

List of artists who reached number one on the U.S. alternative rock chart

Meat alternative

Alternative uses for placenta

Alternative fuel

Alternatives to Darwinian evolution

CoverGirl

Mulesing

Henry A. Wallace Beltsville Agricultural Research Center

Three Rs (animal research)

Bedding (animals)

United States National Agricultural Library

Cruelty-free

Alternative oxidase

Alternative Splicing Annotation Project

Alternatives to the Ten Commandments

Physiologically based pharmacokinetic modelling

Testing cosmetics on animals

Andrey Korotayev

Fixed-dose procedure

L. S. Shashidhara

Animal disease model

TraumaMan

Cell culture

Guimaras State University

Tudor Rickards

9mm P.A.K.

Assyria

Hutterites

Human geography

Benjamin Franklin

Laika (band)

Baytown, Texas

Gateshead

Nonviolent video game

Handsome (Handsome album)

Environmental vegetarianism

The Variation of Animals and Plants Under Domestication

Women's oversized fashion in the United States since the 1920s

Techno

Havre, Montana

Northern Ireland

RAAF Operations Building Site

Dan Schlissel

Neodymium

Magnet school

University of Technology Sydney

Economy of New Zealand

Larry Norman

Zeppelin LZ 54

Metabolism

Team Love Records

Hoe (tool)

Melaleuca linariifolia

Experimentation6

• Every year in the United States, millions of animals including monkey's, rats, mice, rabbits, cats, and dogs suffer experimentation to test the biocompatibility of products before they are used on humans. (nova.edu)
• Some of the most inhumane experimentation is performed on pregnant animals for embryo-toxicity testing. (nova.edu)
• The purpose of this project is to develop biocompatibility and embryo-toxicity screening methods that avoid animal experimentation by using tissue and cell cultures as replacements to animals. (nova.edu)
• These techniques have the potential to i) replace many animal experiments for product testing, ii) reduce the number and type of animal experiments necessary to evaluate products, iii) propose changes to the IOS biocompatibility and embryo-toxicity screening guidelines so that all companies, institutions and investigators are responsible for implementing the use of alternative screening methodologies as an alternative to animal experimentation. (nova.edu)
• ALTA contains original articles and review articles, brief scientific notes, news summaries and comments, meetings reports, book reviews and contributions of readers addressing research into as well as development and application of alternative methods to experimentation on animals in line with the 3R concept. (bioxbio.com)
• Animals in Science provides opportunities to reflect on the ethical implications of animal experiments and poses questions as to whether or not animal experimentation is a valid science. (animalsandus.org.nz)

20211

• The NIH Office of Laboratory Animal Welfare hosted a live webinar in December 2021 entitled, "Best Practices for Conducting a Search for Alternatives and Finding Animal Model/Model Organism Information. (nih.gov)

Welfare13

• Drs. Neera Gopee with the NIH Office of Laboratory Animal Welfare and Christine Livingston with the National Center for Advancing Translational Sciences join us for this conversation (MP3 / Transcript). (nih.gov)
• You must follow the Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals (referred to as PHS policy below) and the Animal Welfare Act . (nih.gov)
• To receive an award, you must have IACUC approval, and your institution must have an Animal Welfare Assurance approved by the NIH Office of Laboratory Animal Welfare (OLAW). (nih.gov)
• To find out if your institution is assured, see the OLAW Domestic Institutions With a PHS Approved Animal Welfare Assurance or Foreign Institutions With a PHS Approved Animal Welfare Assurance . (nih.gov)
• To reduce administrative burden, domestic institutions have the option to use sections of the AAALAC Program Description to complete parts of the OLAW Domestic Animal Welfare Assurance. (nih.gov)
• The annual ICCVAM Public Forum brought together animal welfare groups, federal and industry scientists, and other stakeholders. (nih.gov)
• Representatives of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) described federal agencies' work with animal welfare groups, industry scientists, and other stakeholders to advance new approaches to safety testing of chemicals and medical products in the United States. (nih.gov)
• In addition to animal welfare groups, attendees represented federal agencies, pharmaceutical and chemical companies, and test method developers. (nih.gov)
• In response to Groff's comments, National Toxicology Program (NTP) scientist Warren Casey, Ph.D., described animal welfare organizations as "absolutely some of our best collaborators. (nih.gov)
• Most industries that exploit animals for food, entertainment, fashion, construction, and medicine, focus solely on profit, which comes at the expense of their rights and welfare. (greenlivinguk.org)
• Chemical testing and animal welfare : proceedings from the international seminar arranged in Stockholm, Sweden, May 20-22 1986 by the National Chemicals Inspectorate under the patronage of the Organization for Economic Co-operation and Development. (who.int)
• More and more people are concerned about animal welfare - and it's a topic we take seriously. (unilever.com)
• Designers and researchers who work with animals need to employ an array of ethical competencies to guarantee the welfare of animals taking part in animal-centered research. (open.ac.uk)

Vertebrate6

• We will go into the 3Rs (replace, refine, and reduce), helpful resources for relevant policies, what's needed for the vertebrate animal section, role for IACUCs and peer review, as well as organoids, in silico models, and other alternatives…oh my again! (nih.gov)
• The Frank R. Lautenberg Chemical Safety for the 21st Century Act amended Section 4(h) of the Toxic Substances Control Act (TSCA) to require EPA to develop a Strategic Plan by June 22, 2018 to promote the development and implementation of alternative test methods and strategies to reduce, refine or replace vertebrate animal testing. (nih.gov)
• If you are a principal investigator planning to use live vertebrate animals for research, research training, or biological testing, this page explains how to adhere to requirements, prepare a strong application, and manage your grant. (nih.gov)
• When you apply for NIAID funding, you need to answer the four points in the Vertebrate Animals Section (VAS) of your grant application. (nih.gov)
• Find guidance on completing the VAS in the Worksheet for Review of the Vertebrate Animal Section (PDF) and OLAW's 30-minute training module on how to Complete the Vertebrate Animals Section (VAS) . (nih.gov)
• Foreign assurances last up to five years and may be renewed only for current or pending awards involving vertebrate animals. (nih.gov)

Biomedical research3

• The National Library of Medicine (NLM) Alternatives to Animal Testing (ALTBIB) portal provides access to PubMed/MEDLINE citations relevant to alternatives to the use of live vertebrates in biomedical research and testing. (nih.gov)
• Welcome to ALTBIB, the Bibliography on Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing. (nih.gov)
• Federal agencies promote the use of alternatives to animal testing for biomedical research and toxicity testing. (nih.gov)

Experiments4

• Zebrafish embryos as an alternative to animal experiments. (kit.edu)
• IMSEAR at SEARO: Can large animal experiments be totally replaced by alternatives. (who.int)
• Gupta Madhur, Gupta Y K. Can large animal experiments be totally replaced by alternatives. (who.int)
• We believe that animal experiments should not be used to make sure that our products are safe. (unilever.com)

Methods17

• For example, information is provided on in silico , in vitro , and refined or improved animal testing methods. (nih.gov)
• These subheadings allow users to locate data from in vitro and other alternative methods. (nih.gov)
• Coverage includes results from methods validated by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the European Union Reference Laboratory for Alternatives to Animal Testing (EURL-ECVAM). (nih.gov)
• Development of alternative methods is an active area of research. (nih.gov)
• The ALTBIB search tool provides users with access via PubMed to the latest research on in vitro and computational methods to predict toxicity, as well as approaches to refining animal use for study types that still require animals. (nih.gov)
• ALTBIB also provides links to additional resources on alternative methods research and acceptance. (nih.gov)
• At the recent Advisory Committee to the NIH Director (ACD), one of NIH's newest ACD working groups looking at the issue of Novel Alternative Methods (NAMs) presented a status update. (nih.gov)
• EUSAAT - The European 3Rs Society encourages: Dissemination of information on alternative methods to animal testing, Promotion of research to develop/validate 3Rs methods to replace, reduce, refine animal tests, Promotion of the use of non-animal tests in the area of education and continuing education. (norecopa.no)
• Goals and objectives to inform the Strategic Plan and that can be used for discussion and comment are available at http://www.epa.gov/assessing-and-managing-chemicals-under-tsca/alternative-test-methods-and-strategies-reduce. (nih.gov)
• GAITHERSBURG, MD, BRUSSELS, BE - The European Partnership for Alternative Approaches to Animal Testing (EPAA) has partnered with US based Institute for In Vitro Sciences (IIVS) to produce a series of training videos on non-animal testing methods for the safety evaluation of products and ingredients. (iivs.org)
• Ask senior institutional animal care and use committee (IACUC) members to validate your ideas and methods. (nih.gov)
• Casey directs the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), which organized the meeting on behalf of ICCVAM and provides scientific and administrative support to the committee. (nih.gov)
• It is also presenting a webinar series in partnership with PETA and the Physicians Committee for Responsible Medicine to raise awareness of available non-animal testing methods. (nih.gov)
• The expertise of NICEATM members who use computational and in vitro methods to identify possible carcinogens could greatly reduce the amount of animal testing NTP carries out. (nih.gov)
• ATLA is intended to cover all aspects of the development, validation, introduction and use of alternative methods. (bioxbio.com)
• 7 NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, Research Triangle Park, NC, USA. (nih.gov)
• Currently, the identification of skin sensitising chemicals is most commonly achieved by using animal test methods. (cdc.gov)

Laboratory6

• And, all throughout, perhaps laboratory animals are needed. (nih.gov)
• People for the Ethical Treatment of Animals, a leading international animal rights advocacy organization, has identified companies that 'either test on animals or pay a laboratory to conduct tests on animals. (ewg.org)
• It's also a good idea to find out if your institution has animal facilities accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC). (nih.gov)
• The US Environmental Protection Agency (EPA) announced elimination of all mammal study requests and funding by 2035 , and the Dutch Minister for Agriculture aims for the Netherlands to become the 'world leader in innovations without laboratory animals by 2025' . (rigenerand-biotech.com)
• Alternatives To Laboratory Animals (ATLA) is published 6 times per annum by FRAME. (bioxbio.com)
• 12 European Union Reference Laboratory for Alternatives to Animal Testing, Ispra, Italy. (nih.gov)

Complementary medicine1

• Increasing controversy around vaccines and modern veterinary medicines have made many pet owners and livestock farmers resort to alternative and complementary medicine. (alternative-health-concepts.com)

Testing13

• Computer programs with advanced systems based on large chemical databases can predict a chemical's toxicity, reducing the need for animal testing in some situations. (nih.gov)
• Reducing: A test method that decreases the number of animals required for testing to a minimum while still achieving testing objectives. (nih.gov)
• The IOS recommended the development of new investigative approaches to serve as an alternative to live animal testing, but none, or few alternatives have been developed so far. (nova.edu)
• NLM Resource Update: Alternatives to Animal Testing. (nih.gov)
• In addition to the topic areas for PubMed searches, the ALTBIB portal includes a searchable bibliographic collection of alternatives to animal testing, including citations from published articles, books, book chapters, and technical reports published from 1980 to 2000. (nih.gov)
• The National Library of Medicine (NLM) developed ALTBIB to provide access to PubMed citations for users seeking information on alternatives to animal testing. (nih.gov)
• Participants in a May 23 public forum highlighted collaborations to replace animal use for U.S. safety testing. (nih.gov)
• We've seen examples of collaborations, commitment to reducing animal testing, and greater communication among different stakeholders," noted Katherine Groff of People for the Ethical Treatment of Animals (PETA). (nih.gov)
• She specifically recognized federal agency efforts to reduce animal use for testing of pesticides and medical devices. (nih.gov)
• Both co-chairs of ICCVAM noted how the public forum allows them to connect with others both within and outside the government interested in advancing alternatives to animal testing. (nih.gov)
• Just over 60 years later, it is timely to review progress to date and the future outlook regarding alternative approaches to animal testing. (rigenerand-biotech.com)
• It is important to acknowledge that to date, most scientific breakthrough and biomedical success is grateful to animal use and testing, without which many achievements would not have been possible (for example, increases in cancer survival rates, vaccinations, and the eradication of diseases such as smallpox). (rigenerand-biotech.com)
• Alternatives to animal use in research, testing, and education / Office of Technology Assessment, Congress of the United States. (who.int)

Refine1

• They discuss the 3Rs (replace, refine, and reduce) , helpful resources for relevant policies , what's needed for the V ertebrate Animals Section of grant applications, the role of IACUCs and peer review, as well as organoids, in silico models, and other alternatives. (nih.gov)

Search1

• For example, users can search "ALTERNATIVE IN VITRO TESTS" to locate records with this data. (nih.gov)

Humans6

• Scientists often study the effects of drugs and chemicals on animals before they deem them safe for humans. (nih.gov)
• There is a critical need for alternative animal models that naturally develop diseases commonly observed in humans and can be more appropriate for studying such diseases. (nih.gov)
• This past сеnturу alone hаѕ givеn us ѕо mаnу fashion аltеrnаtivеѕ for animal fur аnd hide, but ѕоmе individuals ѕtill relinquish thе idеа of a реасеful оrdеr between humans аnd animals. (studiocork.com)
• Animals can suffer as much as humans do. (greenlivinguk.org)
• The same test used on animals can be done to check for rabies in humans. (medlineplus.gov)
• Holistic health care is just as important for animals as it is for us humans. (alternative-health-concepts.com)

Distress1

• Refining: A test method that eliminates pain or distress in animals, or enhances animal well-being, such as by providing better housing or enrichment. (nih.gov)

Research9

• The Advisory Committee to the NIH Director recommended ways for NIH to improve the rigor, reproducibility, and translatability of the research we support involving animal models. (nih.gov)
• That's why NIA is exploring additional animal models to expand our research resources. (nih.gov)
• The PHS definition of research animal use includes production of custom antibodies and animals obtained for their tissues. (nih.gov)
• Read about NIH animal research, policies, and crisis management at OER Animals in Research . (nih.gov)
• If your application receives a fundable overall impact score, have your animal use protocol reviewed and approved by an institutional animal care and use committee (IACUC), which evaluates your institution's animal research program. (nih.gov)
• An animal research application requires a lot of work, so start early, leave time for unanticipated issues, and involve experts in your project from the beginning. (nih.gov)
• Since NIH allows just-in-time IACUC approval of animal use protocols, a PI can move a research project all the way through NIH initial peer review before an IACUC has a chance to see it. (nih.gov)
• Drawing from situated ethics approaches, developed to support researchers' ethical engagement with vulnerable populations such as children and differently abled adults, this paper presents an ethics toolkit that aims to support animal-centered research and design by enabling researchers to make ethically sound situated decisions as their work progresses. (open.ac.uk)
• We propose that, beyond supporting ACI research, the toolkit could support the ethical engagement of researchers and practitioners who work for and with animals in many other settings. (open.ac.uk)

Vitro2

• When possible, they try to perform these toxicology tests using biochemical or cell-based ( in vitro ) systems instead of with animals such as mice. (nih.gov)
• The Hazardous Substances Data Bank (HSDB), a part of NLM Toxicology Data Network (TOXNET), now includes subheadings ("/alternative/ and / in vitro tests/") in the Human and Non-Human Toxicity Excerpts fields. (nih.gov)

Pathway6

• genome reveals an alternative pathway for cysteine biosynthesis in animals. (bvsalud.org)
• In animals , cysteine is an important amino acid thought to be exclusively synthesized through the transsulfuration pathway. (bvsalud.org)
• Here, we identify the existence of an alternative pathway for cysteine biosynthesis in animals through the analysis of the genome of the coral Acropora loripes. (bvsalud.org)
• This pathway is also present in most animals but absent in mammals , arthropods , and nematodes, precisely the groups where most of the animal model organisms belong to, highlighting the risks of generalizing findings from model organisms. (bvsalud.org)
• Alternative pathway therapy is currently an accepted treatment approach for inborn errors of the urea cycle. (nih.gov)
• Finally, it must be acknowledged that alternative pathway therapy has limited effectiveness in preventing hyperammonemia and must be combined with effective dietary management. (nih.gov)

Experimental2

• In 1959, The Principles of Humane Experimental Technique was published by Russell and Burch, introducing the 3Rs concept (replacement, reduction, and refinement) regarding animal use in the scientific community. (rigenerand-biotech.com)
• 3). However, there is growing interest in exploring whether it might be possible to design and develop new approaches that would permit an assessment of skin sensitising activity without the need for experimental animals. (cdc.gov)

Models3

• Replacing: A test method that substitutes traditional animal models with non-animal systems such as computer models or biochemical or cell-based systems, or replaces one animal species with a less developed one (for example, replacing a mouse with a worm). (nih.gov)
• In order to explore this issue, NIA organized a workshop last Fall that showcased some new and unconventional options for animal models of Alzheimer's. (nih.gov)
• NIH funding initiatives for marmosets and other new animal models are coming soon. (nih.gov)

Acupuncture1

• At Elmsdale Animal Hospital, we use Acupuncture as a form of physiotherapy. (elmsdaleanimalhospital.ca)

Researchers1

• The emerging field of Animal-Computer Interaction (ACI), which deals with the design of animal-centered interactive systems, considers ethics a fundamental concern when working with animals, and ACI researchers have proposed ethics frameworks in response to these concerns. (open.ac.uk)

Encourages1

• The RSPCA opposes recreational hunting due to the inherent and inevitable pain and suffering caused to animals and strongly encourages alternative ways to demonstrate precision and accuracy using a firearm. (rspca.org.au)

Species1

• Replace animals with non-animal systems or one animal species with a phylogenetically lower one. (nih.gov)

Test3

• A special test called immunofluorescence is used to look at the brain tissue after an animal is dead. (medlineplus.gov)
• This test can reveal whether the animal had rabies. (medlineplus.gov)
• Animal test alternatives. (cdc.gov)

Reduce1

• Reduce the number of animals required to provide scientifically valid results. (nih.gov)

Understood2

• Working towards a world where animals are understood and respected in such a way that they are no longer exploited, abused or made to suffer. (animalsandus.org.nz)
• The metabolic capabilities of animals have been derived from well-studied model organisms and are generally considered to be well understood. (bvsalud.org)

Development1

• The objectives of this workshop were to review the current status of, and future opportunities for, the use of cultured DCs as a basis for the development of alternative approaches to the identification of skin sensitisation hazard. (cdc.gov)

Suffer1

• 130 billion animals suffer every day on factory farms. (greenlivinguk.org)

Study1

• There are also opportunities to study animals in a non-invasive way. (animalsandus.org.nz)

Model1

• and work to support new or early career investigators interested in expanding the range of animal model paradigms. (nih.gov)

Commonly1

• In the раѕt соrk has commonly bееn uѕеd in thе heels оf ѕhоеѕ but now a very thin piece of соrk аlѕо knоwn аѕ cork skin or cork fаbriс iѕ аlѕо uѕеd аѕ a nаturаl and eco-friendly alternative tо animal leather . (studiocork.com)

News1

• Home » Health News » Sex and eroticism: The animal types in the Kamasutra: Which one are you? (alternative-medicine-doctors.com)

Investigators1

• The PHS policy is summarized in the NIH brochure What Investigators Need to Know About the Use of Animals . (nih.gov)

Care2

• participation in its accreditation program sends the message that your institution is committed to high-quality animal care and use. (nih.gov)
• As Hurricane Irma nears Florida, Palm Beach County Animal Care and Control has been receiving reports of abandoned dogs chained up to trees and. (thealternativedaily.com)

Resources2

• To create a sustainable and cruelty-free future, the governments will eventually look to subsidise industries that use fewer natural resources, such as farming crops for human - not animal consumption. (greenlivinguk.org)
• Every other week, we try to bring you articles and resources that would help any pet owner to learn more about holistic animal health. (alternative-health-concepts.com)

Live1

• If you live in a cold area and have pets or farm animals that roam around in your backyard, you should take some special steps to keep them healthy throughout the winter. (alternative-health-concepts.com)

Therapy1

• One of the most frequent uses of Laser Therapy at the Elmsdale Animal Hospital is the treatment of incisions after surgery. (elmsdaleanimalhospital.ca)

EMERGENCY1

• Go to the emergency room or call 911 or the local emergency number if an animal bites you. (medlineplus.gov)

Application1

• Considering alternatives to animals in your application is the topic of our next NIH All About Grants podcast. (nih.gov)