Animal Use Alternatives: Alternatives to the use of animals in research, testing, and education. The alternatives may include reduction in the number of animals used, replacement of animals with a non-animal model or with animals of a species lower phylogenetically, or refinement of methods to minimize pain and distress of animals used.Animal Testing Alternatives: Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.Animal Welfare: The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.Animal Experimentation: The use of animals as investigational subjects.Animals, LaboratoryAnimal Care Committees: Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).Toxicity Tests: An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.

Cardiotoxicity of trastuzumab (herceptin) in chick embryos. (1/28)

The cardiac toxicity of trastuzumab was studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Trastuzumab 5 mg/egg (low dose) or 15 mg/egg (high dose) was injected into the air sac of a fertilized egg on the 16th day of incubation. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After low dosing of trastuzumab, the heart rate was not different compared with the control. However, the heart rate was significantly decreased by high dosing of trastuzumab. In addition, arrhythmia was produced by high dosing of trastuzumab. These findings indicate that trastuzumab has a marked dose- and time-dependent influence on the heart rate in chick embryos.  (+info)

Piscine islet xenotransplantation. (2/28)

Tilapia, a teleost fish species with large anatomically discrete islet organs (Brockmann bodies; BBs) that can be easily harvested without expensive and fickle islet isolation procedures, make an excellent donor species for experimental islet xenotransplantation research. When transplanted into streptozotocin-diabetic nude or severe combined immunodeficient mice, BBs provide long-term normoglycemia and mammalian-like glucose tolerance profiles. However, when transplanted into euthymic recipients, the mechanism of islet xenograft rejection appears very similar to that of islets from "large animal" donor species such as the very popular fetal/neonatal porcine islet cell clusters (ICCs). Tilapia islets are more versatile than ICCs and can be transplanted (1) into the renal subcapsular space, the cryptorchid or noncryptorchid testis, or intraportally as neovascularized cell transplants; (2) as directly vascularized organ transplants; or (3) intraperitoneally after microencapsulation. Unlike the popular porcine ICCs, BBs function immediately after transplantation; thus, their rejection can be assessed on the basis of loss of function as well as other parameters. We have also shown that transplantation of tilapia BBs into nude mice can be used to study the possible implications of cross-species physiological incompatibilities in xenotransplantation. Unfortunately, tilapia BBs might be unsuitable for clinical islet xenotransplantation because tilapia insulin differs from human insulin by 17 amino acids and, thus, would be immunogenic and less biologically active in humans. Therefore, we have produced transgenic tilapia that express a "humanized" tilapia insulin gene. Future improvements on these transgenic fish may allow tilapia to play an important role in clinical islet xenotransplantation.  (+info)

Industrial implementation of in vitro production of monoclonal antibodies. (3/28)

Monoclonal antibodies are widely used at GlaxoSmithKline Biologicals (GSK Bio) for the quantification and characterization of antigens and for the release of vaccine lots. In 1998, GSK Bio decided to change the production of monoclonal antibodies (MAbs) designed for immunological tools from in vivo to in vitro technology. In 2004, all MAbs used at GSK Bio were produced in vitro. These MAbs cover more than 100 different targets with a variety of 1500 hybridomas, and approximately 60 to 90 MAbs are produced every year. This article describes the development process, including a description of the different systems tested based on double membrane or hollow fiber technology. The productivity, assets, and drawbacks of the different technologies are presented, and evaluation strategies for the choice of in vitro systems are discussed. Binding kinetics displayed by MAbs produced in vitro and in vivo were found to be similar, and MAbs produced in vitro are suitable tools for various immunological applications.  (+info)

The new EU REACH regulation has finally been adopted: is this the end of the campaign trail... or just the beginning? (4/28)

The final EU REACH legislation has recently been adopted. This article considers the progress that has been made toward reducing the numbers of animals likely to be required to fulfil the testing requirements, and also considers the benefits to animal welfare and science that have arisen since the original REACH system proposals were published in 2003. Several positive changes have been made, including: the use of exposure-based testing; the requirement for scientific justification of any proposed animal testing; mandatory data sharing; and the fact that the EU is to take responsibility for the development and validation of alternative methods. While these changes are to be commended, there is still much room for improvement, particularly with respect to the adoption of integrated testing strategies that make maximum use of non-animal approaches to expedite the risk assessment process of existing chemicals, with the use of refined and updated animal tests only as a last resort.  (+info)

Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals. (5/28)

Tests for skin sensitization are required prior to the market launch of new cosmetic ingredients and in vitro tests are needed to replace the current animal tests. Protein reactivity is the common feature of skin sensitizers and it is a crucial question whether a cellular in vitro assay can detect protein reactivity of diverse test chemicals. The signaling pathway involving the repressor protein Keap1 and the transcription factor nuclear factor-erythroid 2-related factor 2, which binds to the antioxidant response element (ARE) in the promoter of many phase II detoxification genes, is a potential cellular marker because Keap1 had been shown to be covalently modified by electrophiles which leads to activation of ARE-dependent genes. To evaluate whether this regulatory pathway can be used to develop a predictive cellular in vitro test for sensitization, 96 different chemicals of known skin sensitization potential were added to Hepa1C1C7 cells and the induction of the ARE-regulated quinone reductase (QR) activity was determined. In parallel, 102 chemicals were tested on the reporter cell line AREc32, which contains an eightfold repeat of the ARE sequence upstream of a luciferase gene. Among the strong/extreme skin sensitizers 14 out of 15 and 30 out of 34 moderate sensitizers induced the ARE-dependent luciferase activity and in many cases this response was paralleled by an induction of QR activity in Hepa1C1C7 cells. Sixty percent of the weak sensitizers also induced luciferase activity, and the overall accuracy of the assay was 83 percent. Only four of 30 tested nonsensitizers induced low levels of luciferase activity, indicating a high specificity of the assay. Thus, measurement of the induction of this signaling pathway provides an interesting in vitro test to screen for the skin sensitization potential of novel chemicals.  (+info)

Surgical oocyte retrieval (SOR): a method for collecting mature mouse oocytes without euthanasia. (6/28)

A novel surgical method for collecting oocytes from unique and irreplaceable mice is described. This method, surgical oocyte retrieval (SOR), facilitates the collection of ovulated oocytes, does not require euthanasia, and preserves reproductive potential. The surgery involves a small incision in the ampulla region of the oviduct, through which the cumulus oocyte mass is removed with a gel-loading pipette. The incision then is closed by using a tissue adhesive, which is required to ensure healing of the incision and containment of any oocytes ovulated after SOR. Two anesthetics, isoflurane and tribromoethanol, were compared for oocyte toxicity during SOR. More dead oocytes were recovered when tribromoethanol was used than when isoflurane was used. Combining SOR and traditional oocyte collection methods yielded more oocytes per BALB/cByJ than did traditional methods alone (41 versus 28 oocytes, respectively). Oocytes collected by using SOR were fertilized and subsequent embryos developed to term comparable to controls. This technique provides an alternative method for oocyte collection and will be valuable for maximizing the number of oocytes from irreplaceable mice.  (+info)

Reduced hamster usage and stress in propagating Leishmania chagasi promastigotes using cryopreservation and saphenous vein inoculation. (7/28)

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Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. (8/28)

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*UCDavis Center for Animal Alternatives

... disseminates information on alternatives to animal experiments and provides animal ... Center for Alternatives to Animal Testing Dr Hadwen Trust Official website. ... experimenters with information on the most current methods for improving all aspects of animal care. ...

*Center for Alternatives to Animal Testing

Alternatives to animal testing UCDavis Center for Animal Alternatives Dr Hadwen Trust Henry Spira Official website. ... a global clearinghouse for information on alternatives to animal testing, and publishes a general animal news blog, A Boundless ... and academia to find new ways to replace animals with non-animal methods, reduce the numbers of animals necessary, or refine ... The Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) has worked with scientists since 1981 to find new ...

*European Partnership for Alternative Approaches to Animal Testing

The European Partnership for Alternative Approaches to Animal Testing (EPAA) promotes the application of Russell and Burch's ... systems biology and stem cells Alternatives to animal testing EPAA conference 2005 EPAA Mirror Group minutes EPAA partners ... and European industry sectors involved in the development of alternative approaches toward animal experimentation. The actions ... animal welfare groups, laboratory animal science associations and national authorities. Members of the EPAA as of March, 2012 ...

*DMOZ - Health: Animal: Alternative Medicine

This category is made up of topics that explore animal health related issues using alternatives to the western scientific/ ... Taranet Alternative Animal Therapies Source of complementary animal therapies, including acupuncture, animal communication, ... Alternative Pet Health Articles and discussion forums on alternative pet health and natural rearing, indexed by animal and by ... Natural Animal Health Chiropractic, homoeopathy, massage, herbs, acupuncture and other natural/alternative therapies for ...

*DMOZ - Health: Animal: Alternative Medicine: Essences

... animal essences, etc. It is intended for educative, service-oriented, non-commercial sites, although commercial sites with ... This category explores essence therapy in animals, to include flower essences, ... This category explores essence therapy in animals, to include flower essences, animal essences, etc. It is intended for ... Flower remedies help restore the balance and harmony of an animal's true nature. ...

*DMOZ - Health: Animal: Alternative Medicine: Chiropractic

... in animals. It is intended for educative, service-oriented, non-commercial sites (although commercial sites with valuable ... McTimoney Animal Therapist Emily J Lawson is a fully qualified McTimoney therapist for animals. She explains this non-invasive ... London Animal Chiropractic A small animal chiropractor based in Central London, United Kingdom, providing safe, effective and ... McTimoney Animal Association Professional association for McTimoney Animal Practitioners in the UK. Includes information on the ...

*DMOZ - Health: Animal: Alternative Medicine: Reflexology

Health/Alternative_Medicine/Reflexology is a category made up of topics that explore using refloxology in animals. This ... Science/Biology/Zoology/Animal_Health/Alternative_Medicine/Reflexology is a category made up of topics that explore using ... Animal reflexology and animal massage therapy in British Columbia. Human reflexology and massage also. ... refloxology in animals. This category is intended for educative, service-oriented, non-commercial sites, although commercial ...

*DMOZ - Health: Animal: Alternative Medicine: Practitioners

... of complementary and alternative healing methods which are alternatives to the western scientific/medicine (allopathic) ... This category is for mixed animal practitioners (veterinarians and others) ... Animal Friend Offers a range of holistic care services for dogs and other animals including animal aromatics, canine massage, ... Holistic Animal Medicines Diana Hayes, homeopath and holistic practitioner offers information on alternative therapies and an ...

*DMOZ - Health: Animal: Alternative Medicine: Dogs

This category is made up of topics that explore health related issues using alternatives to the western scientific/medicine ( ... Pawsitive Animal Therapies Offers myofunctional massage therapy, Bowen therapy, craniosacral therapy and Reiki for dogs and cat ... Dog Owner's Guide: Alternative Diets and Holistic Treatments Provides information on diet, vaccinations, parasite control, ... This category is made up of topics that explore health related issues using alternatives to the western scientific/medicine ( ...

*DMOZ - Health: Animal: Alternative Medicine: Herbs

This category explores the use of herbs in animals. It is intended for educative, service-oriented, non-commercial sites, ... This category explores the use of herbs in animals. It is intended for educative, service-oriented, non-commercial sites, ... Winged Wisdom Pet Bird Magazine - Article on holistic medicine, and alternative therapies such as herbal remedies for pet birds ...

*DMOZ - Health: Animal: Alternative Medicine: Livestock

This category explores health related issues using alternatives to the western scientific/medicine (allopathic) remedies in ... Holistic Approach to Animal Health An holistic veterinary model for farm animal livestock disease and welfare situations is ... This category explores health related issues using alternatives to the western scientific/medicine (allopathic) remedies in ...

*DMOZ - Health: Animal: Alternative Medicine: Equine

This category explores health related issues using alternatives to the western scientific/medicine (allopathic) remedies in the ... Equisearch: Alternative Therapies Articles and information about alternative health care and holistic therapies for horses, ... An alternative health magazine for horse and rider. Regular features include equine therapies, herb usage, pasture management, ... Natural Horse Magazine covers natural and holistic care for horses, humane training, kids riding, alternative care, and ...

*DMOZ - Health: Animal: Alternative Medicine: Aromatherapy

This category explores aromatherapy in animals. It is intended for educative, service-oriented, non-commercial sites, although ... Site devoted to educating animal owners in the use of aromatherapy for their pets' well-being. ... This category explores aromatherapy in animals. It is intended for educative, service-oriented, non-commercial sites, although ... ailments in animals and their treatment, aromatic veterinary medicines, "key" aromatic blends and practical advice. ...

*DMOZ - Health: Animal: Alternative Medicine: Homeopathy

This category explores homeopathy in animals. It is intended for educative, service-oriented, non-commercial sites (although ... Animal Natural Health Center Training and information for veterinarians and guidance to owners interested alternative medicine ... This category explores homeopathy in animals. It is intended for educative, service-oriented, non-commercial sites (although ...

*DMOZ - Health: Animal: Alternative Medicine: Exotics

Exotic animals include birds, wildlife, rodents, lagomorphs (rabbits), reptiles, amphibians, and small mammals (rodents and ... This category is made up of topics that explore exotic animal health related issues using alternatives to the western ... Alternative Therapies for your Hedgehog Color therapy, aromatherapy, crystal healing, Bach Flower Essences, animal ... This category is made up of topics that explore exotic animal health related issues using alternatives to the western ...

*DMOZ - Health: Animal: Alternative Medicine: Cats

This category is made up of topics that explore health related issues using alternatives to the western scientific/medicine ( ... This category is made up of topics that explore health related issues using alternatives to the western scientific/medicine ( ... Discussion group to share views of and experiences with alternative treatments for cats. ...

*DMOZ - Health: Animal: Alternative Medicine: Professional Organizations

This category is made up of professional organizations with practitioner members that support animal health related issues ... using alternatives to the western scientific/medicine (allopathic) remedies, including acupuncture, herbs, aromatherapy, ... International Alliance for Animal Therapy and Healing IAATH brings together complementary and alternative animal healers and ... Holistic Animal Therapy Organisation HATO represents animal therapists in Australia employing healing methods to address the ...

*DMOZ - Health: Animal: Alternative Medicine: Homeopathy: Practitioners

Homeopathic Veterinary Clinic in Vancouver, BC, Canada, owned by Julie Anne Lee, offering natural care for your pets, including nutrition counselling, reiki, natural health products, and books. ...

*DMOZ - Health: Animal: Alternative Medicine: Herbs: Catnip

This category explores the use of catnip in animals. It is intended for educative, service-oriented, non-commercial sites, ... This category explores the use of catnip in animals. It is intended for educative, service-oriented, non-commercial sites, ...

*DMOZ - Health: Animal: Alternative Medicine: Massage Therapy

... and reflexology in animals. It is intended for educative, service-oriented, non-commercial sites, although commercial sites ... Animal Massage Therapists to be Licensed News story about proposed licensing of animal massage therapists in the state of ... Northwest School of Animal Massage Training programs offered include large and small animal distance learning certification ... International Association of Animal Massage Therapists Equine massage and canine massage therapists have come to find the ...

*DMOZ - Health: Animal: Alternative Medicine: Equine: Practitioners

... of complementary and alternative healing methods which are alternatives to the western scientific/medicine (allopathic) ... remedies, and treat horses, mules, donkeys and other equine animals. This category is intended for educative, service-oriented ... Provides a biography of Holly and information on the services she offers in animal communication, healing and animal assisted ... of complementary and alternative healing methods which are alternatives to the western scientific/medicine (allopathic) ...

*DMOZ - Health: Animal: Alternative Medicine: Physical Therapy

This category explores physical therapy and rehabilitation in animals, including hydrotherapy and passive exercise. It is ... Liz Harris: Animal Physical Therapist Offers McTimoney, massage and Reiki therapy for horses, dogs and other animals for North ... College of Animal Physiotherapy Provides details of the courses offered at Aylesbury, UK. Also offers sale and hire of ... Summary of presentation at the World Small Animal Veterinary Association World Congress, by Robert Taylor, DVM. ...

*DMOZ - Health: Animal: Alternative Medicine: Oxygen Therapy

... in animals. It is intended for educative, service-oriented, non-commercial sites, although commercial sites with valuable ... This category explores oxygen and ozone therapy (including hyperbaric treatments) in animals. It is intended for educative, ...

*DMOZ - Health: Animal: Alternative Medicine: Energy Healing

This category explores animal health related issues related to energy healing. Some forms of energy healing, including magnet ... Healing Touch for Animals and Komitor Healing Method Energy-based healing method that bridges holistic animal healthcare with ... For all animals: horses, dogs, cats, birds, exotic animals. Workshops, books, and products. ... Stratton School of Animal and Horse Healing Touching Spirit Center is an educational center in the science of energy medicine ...

*Cellulosic ethanol commercialization

The US Federal government is actively promoting the development of ethanol from cellulosic feedstocks as an alternative to ... and has been tested as a high carbohydrate animal feed supplement and potential bio-based feedstock for production of numerous ...
keratinocytes - Based on automatic parsing from source available in http://www.nal.usda.gov/awic/alternatives/alternativeanimalusethesaurus.htm
The threshold of toxicological concern (TTC) is a principle which refers to the possibility of establishing a human exposure threshold value for all chemicals, below which there is no appreciable risk to human health. The concept that exposure thresh
Japans largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
You should try to quit smoking, and avoid being around people who smoke. Cigarette smoke contains benzenes, which have been shown to have a significant effect on blood pressure. High blood pressure, in turn, is often connected to tinnitus. If you cant quit, at least try to cut back and see if that helps. Try different strategies when trying to go to sleep with tinnitus. Make sure the room you are sleeping in is completely dark. When you lie down, try to think of relaxing things, such as ocean waves or relaxing on a beach after sundown. Keeping your mind occupied with relaxing thoughts will help you fall asleep fast. Meditation offers relief for many that suffer from tinnitus. Yoga, deep breathing techniques and massage therapy can also decrease stress and relieve tension-related tinnitus. Meditation helps users focus on their breathing and relaxation which will help to eliminate the distractions associated with tinnitus. Training the mind in this way can help those with tinnitus concentrate on ...
In light of improving analytical methods, it can be expected that many more unintended chemicals will be detected in our environment, including food and drinking water, and in our bodies. The TTC approach is a screening and prioritization tool for the safety assessment of chemicals when hazard data are incomplete and human exposure can be estimated. TTC is not applicable when compound-specific assessment and toxicity data are available or are required under existing regulations.
Environmental risk assessment is often affected by severe uncertainty. The frequently invoked precautionary principle helps to guide risk assessment and decision-making in the face of scientific uncer
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University of Cambridge. Illuminating cell fate decisions in the implanting primate by embryo profiling and ex vivo functional analysis. Cells in the early embryo are of particular interest as they harbour the potential to form all cell types found in the adult body. Most of our knowledge about these cells is based on mouse studies. However, early development in human and non-human primates radically diverges from the rodent paradigm. Primates even form additional placental tissues upon implantation. Despite the tremendous potential for biomedical research, the underlying mechanisms remain unknown.. I propose to investigate the primate-specific aspects of early development of the embryo after implantation, building on strong collaborations with primate centres in Germany and Japan. Gene expression analysis of marmoset embryos post-implantation using the latest next-generation sequencing techniques will identify regulators of cell-fate decisions. This can only be done in a non-human primate, ...
Does gene number correlate with complexity? As shown in the adjacent table, it obviously does not. Rather, alternative splicing correlates with complexity. 95% of Human genes are known to exhibit alternative splicing. Complex Transcription Units use alternative splicing to produce more than one type of mRNA. Patterns of RNA spliciing can combine to produce a dizzying array of alternatively spliced isoforms.. The Slo or Bk channel has over 500 isoforms.the neurexin protein has 2,346 isoforms; the para-sodium channel has 1,536 isoforms; the Drosophila DSCAM Receptor can potentially be made in 38,016 different spliced isoforms. Somatic sexual development in Drosophila is controlled by a cascade of splicing factors each regulating the splicing of genes downstream in the pathway. And cochlear hair cells are tuned to respond to different frequencies via alternative RNA splicing.. Alternative RNA splicing is an important aspect of gene control in metazoans (multicellular animals). Two general molecular ...
Natural Healthcare, A practical guide to alternative treatment via a natural medicine or remedy. Use alternative natural healthcare medicine products for that alternative remedy or treatment.
...In the light of growing concerns about the separation of producers and...Through participation consumers tended to increase their consumption ...Although the majority of consumers use alternative food sources alongs...People take part in alternative food networks for a range of economic...,Alternative,food,networks,connect,ethical,producers,and,consumers,and,can,lead,to,healthier,eating,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Quasi Vivo® systems offer an affordable and easy to use alternatives to animal testing for use within the drug development pipeline.
The annual pet exam provides an opportunity to use alternative pet medicine, including home methods to give your pet a physical, the in-depth holistic physical and the physical for older pets.
RICHMOND -- A 16-year-old cancer patient fighting to use alternative medical treatment said he told a juvenile court judge in a two-day, closed-door hearing what it is like to go through chemotherapy and that he didnt want to relive it.
Swedens Environment Minister, Andreas Carlgren, said in May that "If the EU will not quickly forbid the hormone disrupting substance bisphenol in baby-bottles Sweden will precede with a national prohibition.". In June, Germany also broke EU ranks, issuing new guidance calling on "manufacturers, importers and users of bisphenol A to use alternative substances that pose less risk to human health and the environment in all areas of use that significantly contribute to exposure." Denmark and France have both outlawed using the chemical in baby bottles.. The U.S. Food and Drug Administration announced in January that it has "some concern" about the chemical, but is continuing to review the rapidly growing body of scientific evidence on the matter. The National Institutes of Health recently launched a $30 million research initiative to study low level BPA exposure ...
Angell M, Kassirer JP. Alternative medicine - the risks of untested and unregulated remedies. New England J. Med. 339: 839-841, 1998 Medline. Aronson KF, Howe GR, Carpenter M, Fair ME, Surveillance of potential associations between occupations and causes of death in Canada, 1965-91. Occup. Environ. Med. 56: 265-269, 1999 Medline. Astin Ja. Why patients use alternative medicine: results of a national study. JAMA 279: 1548-1553, 1998 Medline. Baranov VS, Ivaschenko T, Bakay B, et al. Proportion of the GSTM1 o/o genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases. Human Genetics 97: 516-520, 1996 Medline. Barnett PA, Spence JD, Manuck SB, et al. Psychological stress and the progression of carotid artery disease. J. Hypertens. 15: 49-55, 1997 Medline. Berman BM, Singh BK, Lao L, et al. Physicians attitudes toward complimentary or alternative medicine: A regional survey. J. Am. Board Fam. Pract. 8: 361-365, 1995 Medline. Blumberg DL, Grant ...
For the past week I have been using a new blood glucose meter courtesy of LifeScan. Jeff Christensen, LifeScans communication manager in Milpitas, California, came to my home to demonstrate the meter to me. His demonstration and my use of the meter was persuasive. I have permanently retired my previous meter, the Accu-Chek Compact, as good as it is. One thing that the Compact isnt, however, is a meter that facilitates testing on alternative sites. It claims to have that capability, but since it requires a 3 microliter sample, I found that I usually had to puncture my arm three times to get enough blood. Several bruises were the long-term result. My endo says that a meter should require 1 microliter or less to be able to use alternative sites. I agree. The UltraSmart requires 1 microliter and returns the result in just five seconds. I was so sold that I switched, even though my insurance doesnt cover LifeScan test strips. The UltraSmart works the same as the Ultra, except that it includes ...
Depending on the type of blotting (tank or semi-dry blotting) and the specific characteristics of the proteins, different buffers may be used for Western Blotting. For small proteins or for tank blotting after SDS PAGE Towbin Buffer is recommended, for blotting proteins after SDS PAGE or IEF by semi-dry blotting, a discontinuous buffer system is recommended. A fast and easy to use alternative for optimal semi-dry blotting is SERVAs Xpress Blotting Kit. The buffer system enables in combination with the newly developed alternative for blotting paper, the Blotting Fleece, an efficient simultaneous transfer of high and low molecular weight proteins in only 15 minutes ...
Antiretroviral (ARV) treatment guidelines currently recommend ARV regimens containing a Nucleos(t)ide Reverse Transcriptase Inhibitors [N(t)RTI(s)] based backbone with a Non Nucleoside Reverse Transcriptase Inhibitor (NNRTI) or ritonavir boosted Protease Inhibitor (PI/r).(1) However, significant toxicity has been associated with N(t)RTI(s) and PI/r containing regimens. N(t)RTI(s) can cause lipoatrophy, lipid elevations, renal toxicity, neuropathy and lactic acidosis.(1) These toxicities have required clinicians and HIV-infected individuals to use alternative ARV regimens that do not use N(t)RTI(s). PIs are known to cause gastrointestinal side effects, dyslipidemia, and fat maldistribution (lipodystrophy).(1) The DHHS HIV treatment guidelines recommend that PIs should be given with a low dose of ritonavir (RTV). RTV is a PI that has an inhibitory effect on cytochrome P-450 3A4 isoenzyme which metabolizes most PIs. The addition of RTV serves as a pharmacokinetic booster by increasing PI drug ...
Hi Monica: Here are the sites to research on. Your friend and good luck, lillian WELCOME TO YOUR MOL CANCER FORUM Here you will meet a wonderful caring group of individuals who are cancering or who are loved ones and friends being advocates for those cancering. Individuals in this group are not in the medical professional field. Therefore,we do not endorse a treatment, drug or product. Our people combined do have many years of accumulated knowledge and expierence, who come from all walks in life and are able to lend tremendous assistance to help you walk through this journey. There are a few matters of importance to address. It is the general assumption of the group that one can use alternative treatments (with your doctors permission) in conjunction with traditional therapy. We feel that an individual who has had testing and is returning to the doctor should take someone with them as an extra set of ears. It must be remembered that this is a most stressful time for you. We also agree that a ...
A Ribonucleic acid (RNA) is a molecule found in all cells, comprised of many individual units of nucleic acid. It differs from DNA (deoxyribonucleic acid) in that it only contains a single, not double strand, and substitutes uracil for thymine. The sugar backbone of RNA is also composed of ribose (DNA contains deoxyribose). RNAs fall into several different categories, depending on function. The primary role of mRNA in is to transfer a copy of the information coded in DNA to a ribosome to be expressed as a protein, using a form of RNA known as messenger RNA (mRNA). mRNA in eukaryotes undergoes spicing after transcription from DNA to remove introns or to use alternative splicing to create a different gene product. Alternatively-spliced transcripts can also express the same protein, but at different levels, due to the removal or addition of regulatory sequences. The main role of tRNA, or transfer RNA is to carry an amino acid to the mRNA (while the mRNA is in the ribosome) during translation of the ...
New research has found that women frequently use alternative treatments to manage their menopause symptoms but often do not inform their doctors about them.
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Increased risk of asthma-related events (death, hospitalizations, intubations) with LABA monotherapy (without ICS). Do not initiate in rapidly or acutely deteriorating asthma. Not for use with other long-acting β2-agonists. Do not exceed recommended dose. Prescribe a short-acting, inhaled β2-agonist for acute symptoms; monitor for increased need. Immunosuppressed. Tuberculosis. Systemic infections. Ocular herpes simplex. If exposed to chickenpox or measles, consider immune globulin prophylaxis or antiviral -treatment. Monitor for adrenal insufficiency when transferring from systemic steroids. May need supplemental systemic corticosteroids during periods of stress or severe asthma attack. May unmask previously suppressed allergic conditions. Reevaluate periodically. Monitor for hypercorticism and HPA axis suppression (if occurs, discontinue gradually), growth in children, intraocular pressure, glaucoma, or cataracts. Discontinue if paradoxical bronchospasm occurs; use alternative therapy. ...
Neurovascular MR angiography (MRA) is rapidly gaining greater clinical acceptance. To provide functional information, novel techniques of acquisition, information processing, and display are used, generating a new set of artifacts. The purpose of this paper is to outline the causes, provide examples, and note clinical problems associated with MRA artifacts by grouping them into six common types: 1) poor visualization of small vessels, 2) overestimation of stenosis, 3) view-to-view variations, 4) false positives, 5) false negatives, and 6) vessel overlap. This in turn will lead to four generalized solutions: 1) optimize acquisition parameters, 2) edit volume boundaries before performing maximum intensity projection reconstructions, 3) refer to the individual source images, and 4) use alternative image processing. By organizing and simplifying both clinical problems and solutions into major categories, a greater understanding of the current clinical indications and the overall goals of MRA can be ...
COMMUTERS can make it pay to leave their cars at home and use alternative methods of transport along one of Sheffield’s busiest routes.
Countries compiling quarterly estimates for gross domestic product (GDP) often use alternative approaches simultaneously. This may result in the publication of different measures of quarterly GDP and discrepancies between these measures. Such discrepancies are unavoidable, unless reconciliation takes place or the measures are mutually interdependent. This paper examines international practices in this respect, focusing on OECD member countries that publish quarterly GDP data. Of these, five publish GDP data with discrepancies-the United States, the United Kingdom, Canada, Australia, and New Zealand-and the paper examines causes and the development of these discrepancies.
If you are seeing a blank page in searching using Google.com, your computer is infected with a virus. To fix the google blank page virus infection, use a removal tools in this article. Do not use alternative browser as work-around on google.com redirect infection.
I just returned from a mini-tour. Four days, four states, two shows, one workshop, three radio interviews, and a television show. And four tanks of gas. (Obviously, I dont have a Prius.). I remember a conversation from a few years ago. Some friends and I decided that gas should be five bucks a gallon. Our thinking? That would be the only way to motivate anyone to use alternative energy. So, even though its uncomfortable at times, and even though I dont love why gas prices are rising, I believe that good things are happening.. But, heres the thing: Lots of people are talking about "hard times." I even noticed the temptation to go there as I filled up my tank out on the road. Luckily, I catch myself when this happens. I take a breath. And I shift my thoughts. I had a great road trip. And I continue to feel (and be) prosperous.. Remember, you can have a powerful dream or vision for yourself. You can do all the right meditations and create effective action plans. But if you sink into negative ...
The NHPD Ingredient Database contains the ingredient information which the Natural Health Products Directorate has developed for ingredients that are generally regarded to be of minimal toxicological concern
The NHPD Ingredient Database contains the ingredient information which the Natural Health Products Directorate has developed for ingredients that are generally regarded to be of minimal toxicological concern
1992, TRS 828-JECFA 39/15, FNP 25-JECFA 26/160 (1982) (COMPENDIUM/1245). ACCEPTABLE (CURRENT USE LEVELS UP TO 75 MG/L (AS QUININE BASE) IN SOFT DRINKS NOT OF TOXICOLOGICAL CONCERN). AC. S ...
my $name = $marker-,name(); # marker name my $description = $marker-,description(); # description my $type = $marker-,type(); # coded type of the marker my $unique_id = $marker-,unique_id; # optional unique ID my @alleles = $marker-,get_Alleles(); # the known alleles my %allele_freqs = $marker-,get_Allele_Frequencies(); # keys are marker names # vals are frequencies # may change to handle multiple populations ...
Please include a link to this page if you have found this material useful for research or writing a related article. Content on this website is from high-quality, licensed material originally published in print form. You can always be sure youre reading unbiased, factual, and accurate information.. Highlight the text below, right-click, and select "copy". Paste the link into your website, email, or any other HTML document.. ...
We often see female and male models in a studio setting, it has become a very large part of our advertising culture. For this series I wanted to put animals in that very setting we are so accustomed to seeing people in, all while still capturing their e…
Log in to read EU Regulation 900/2014/EU: Amending Regulation (EC) No 440/2008 laying down test methods to be applied for the purposes of the EU REACH Regulation, and key environmental and carbon legislation and policy documents on The ENDS Report
Influence of chemical and mechanical stress on precision-cut lung slices [Elektronische Ressource] / Constanze Dassow : Influence of chemical and mechanical stress on Precision-cut Lung Slices Von der Fakultät für Mathematik, Informatik und Naturwissenschaften der RWTH Aachen University zur Erlangung des akademischen Grades einer Doktorin der Naturwissenschaften genehmigte Dissertation vorgelegt vonDiplom-Humanbiologin Constanze Dassowaus Bad OldesloeBerichter: Universitätsprofessor Dr. Stefan Uhlig Univtsprof
If youve ever been in a sauna then you know first hand how rejuvenating and invigorating a good sweat can be. Sweating is a form of detoxification and there may be no better place to stimulate this process than in the sauna. Sauna therapy developed in the Scandinavian region, specifically Finland, and is used for bathing, improving ailments, and even as a setting for childbirth. To say the sauna is a foundational element of Finnish society would be an understatement, some even view it as a holy place and behave as they would in a church. Its no wonder, more than just a place to feel good, the sweat inducing heat is also thought to balance many health problems including hypertension, fatigue, discomfort, and even certain cravings.. Many formal studies have set out to determine the health benefits of using a sauna and the outcomes have been very positive.. 1. May Offer Fibromyalgia Symptom Support. The Department of Rehabilitation and Physical Medicine at Japans Kagoshima University conducted a ...
Video articles in JoVE about osteogenesis distraction include An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur, Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects, Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models, A Surgical Procedure for Resecting the Mouse Rib: A Model for Large-Scale Long Bone Repair, Psychophysiological Assessment of the Effectiveness of Emotion Regulation Strategies in Childhood, A Cognitive Paradigm to Investigate Interference in Working Memory by Distractions and Interruptions, An Improved Mechanical Testing Method to Assess Bone-implant Anchorage, Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts, Task Interruption and Resumption Paradigm for Testing the
Precision-cut lung slices of pigs were infected with five swine influenza A viruses of different subtypes (A/sw/Potsdam/15/1981 H1N1, A/sw/Bad Griesbach/IDT5604/2006 H1N1, A/sw/Bakum/1832/2000 H1N2, A/sw/Damme/IDT5673/2006 H3N2, A/sw/Herford/IDT5932/2007 H3N2). The viruses were able to infect ciliated and mucus-producing cells. The infection of well-differentiated respiratory epithelial cells by swine influenza A viruses was analyzed with respect to the kinetics of virus release into the supernatant. The highest titres were determined for H3N2/2006 and H3N2/2007 viruses. H1N1/1981 and H1N2/2000 viruses replicated somewhat slower than the H3N2 viruses whereas a H1N1 strain from 2006 multiplied at significantly lower titres than the other strains. Regarding their ability to induce a ciliostatic effect, the two H3N2 strains were found to be most virulent. H1N1/1981 and H1N2/2000 were somewhat less virulent with respect to their effect on ciliary activity. The lowest ciliostatic effect was observed with
Caring for your lawn properly is just a small part of healthy gardening. The following general suggestions are some cheap and easy ways to promote healthy living for you, your family, wildlife, and the environment. Use alternative lawn care: Chemical lawn care systems leach into and contaminate water supplies. Choose alternative lawn care that contains all-natural and environmentally friendly weed control and fertilizing components. Want a green, healthy, weed-free lawn but dont want the dangers of chemicals? Youll never need those little flags warning kids and pets to stay off your treated turf again. With the growing awareness of natural and organic living, alternative methods for lawn care are now being offered. Look for products that are safe to use around children and pets and that keep water supplies clean.. Grow healthy, chemical-free fruits, veggies, herbs: With the increasing awareness of harmful effects from chemical residue intake, it is wise to provide your family with organic and ...
Air Products has signed a contract with SK Energy to construct a hydrogen fueling station for a novel energy project to be based in World Cup Park in Seoul, South Korea. The hydrogen fueling station to be on-stream in July 2010 will supply hydrogen produced solely from landfill gas to fuel a fleet of vehicles. The project is part of Seouls push to use alternative supply means to generate 10 percent of its energy consumption by 2020, and to use hydrogen for 30 percent of the switch.. "This is a very innovative project with high goals, and we are proud to be part of this plan and to work with SK Energy, which is a leading Korean company in hydrogen reforming technology. Seoul should be applauded for its foresight to use this project and World Cup Parks prominent name and location as a showcase and model for its future energy plans," said Bob Kelly, business development manager for Hydrogen Energy Systems at Air Products. "Processing a waste stream to make hydrogen for use as an alternative fuel ...
Many statistical analyses in ophthalmic and other clinical fields are concerned with describing relationships between one or more predictors (explanatory or independent variables) and usually one outcome measure (response or dependent variable). Our earlier statistical notes make reference to the fact that statistical techniques often make assumptions about data.1 ,2 Assumptions may relate to the outcome variable, to the predictor variable or indeed both; common assumptions are that data follow normal (Gaussian) distributions and that observations are independent. It is, of course, entirely possible to ignore such assumptions, but doing so is not good statistical practice and in medicine; poor statistical practice can impact negatively upon patients and the public.3. One approach when assumptions are not adhered to is to use alternative tests which place fewer restrictions on the data - non-parametric or so-called distribution free methods.2 A more powerful alternative, however, is to ...
Due in large part to the high volume of traffic that clogs the citys streets and freeways, Los Angeles air quality is notoriously bad. And research has shown that fumes from all of those vehicles increase L.A. residents risk for respiratory and cardiovascular disease.. Downtown and East Los Angeles, in fact, are among the California communities with the worst environmental conditions according to an Office of Environmental Health Hazard Assessment report; both rank among the states bottom 10 percent.. For years, city officials, policymakers, environmentalists and others have introduced initiatives to encourage residents to reduce their use of cars and instead use alternative transportation, such as public transit, carpools, walking and cycling.. One example is CicLAvia, a series of one-day events organized by a local nonprofit in which neighborhood streets are closed to motor vehicles so that people can walk and cycle freely. According to the organization, more than 1 million people have ...
The result of 10 years plus of research and health care (at the time of printing my copy was printed in 1981) helping you to understand and learn about: self-examination, the vagina and its ecology and secretions, the cervix and the uterus - including myths behind cervical cauterization and the "tipped uterus", Infertility. Prevent and use alternative treatment for: menstrual cramps and distress, urinary tract infections, vaginal infections, herpes, pelvic pain, pain during intercourse, nausea during pregnancy. helping take the mystery out of a medical visit by learning: how to choose a health care facility, what happens on a medical visit, how standard laboratory tests are done and what they show, what are accepted medical treatments and what are their risks, the terms most often used by gynecologists and what they mean in everyday language ...
Sean Russell2018-02-13T00:07:15+00:00. A Guide to DIY Herbal Supplements plus Recipes 20% of the population uses herbal medicine and herbal supplements 40% of the population use alternative medicine therapies such as acupuncture The natural supplement industry has been booming over the last 10 years. Supplement use has grown steadily at 8% since 2013 where it was already a healthy industry. This growth is from several factors, with supplement growth mostly due to increased public demand. The supplement industry is growing thanks to: Increased research of.... ...
Nationalist and patriotic sentiments frequently cause headaches for Christian leaders and pose particular challenges for the church or mission agency leader responsible for managing multi-national teams. This simple observation requires us to understand the scope and significance of nationalism in the context of global mission.. While populist parties stir up fears, the churches often struggle to express a clear kingdom perspective. In some instances the churches find themselves, wittingly or unwittingly, portrayed as patriotic allies in the struggle to stem the influx of non-Christian immigrants.. Nationalists, above all else, issue a call to difference in the face of homogenizing forces that are global in nature. In resisting globalisation, most nationalisms use alternative narratives that are mythological, such as frontier myths and sacred origin myths.. The Lausanne Movements commitment to a vision of the one worldwide body of Christ, fuelled by passion and enthusiasm, is entirely ...
One of the great achievements of the omics revolution is the development of high throughput functional genomics approaches. Notably transcriptomics studies have been instrumental in analyzing the response of LAB to different environments and over 100 papers have been published addressing a variety of stresses, growth conditions and culturing regimens. Among the most important practical discoveries was the finding that Lactococcus lactis and other LAB, when provided with the appropriate cofactors, such as heme, could use alternative electron acceptors and hence respire rather than ferment [82]. Following the first description of the use of molecular oxygen by Lactococcus lactis MG1363 [83], a variety of studies have followed that have been reviewed recently [84]. Transcriptional studies allowed to identify the genes involved in the use of molecular oxygen that resulted in a wide range of applications, notably faster growth and higher yield of starter cultures [85]. Biochemical studies confirmed ...
This report updates information previously published regarding contamination of Vapotherm® respiratory gas administration devices (Vapotherm, Inc., Stevensville, Maryland) with Ralstonia spp. (1,2). The Food and Drug Administration (FDA) has issued an updated Preliminary Public Health Notification, advising health-care providers to use alternative devices until the source of the contamination has been identified.* CDC continues to receive information regarding Ralstonia spp. associated with Vapotherm use. Twenty-nine institutions in 16 states have reported recovery of Ralstonia spp. from Vapotherm devices and from approximately 40 pediatric patients. The majority of these cases appear to represent colonization, although one infection has been reported to CDC and other cases remain under investigation. In addition, the recommended disinfecting protocol has reportedly failed to eradicate Ralstonia spp. in three separate tests. Based on pulsed field gel electrophoresis analysis, isolates from ...
Downloadable! This paper studies the proposition that capital inflows tend to take the form of FDI--i. e. , the share of FDI in total liabilities tends to be higher--in countries that are safer, more promising and with better institutions and policies. It finds that this view is patently wrong since it stands the historical record on its head. It then uses alternative theories to make sense of the facts. It begins by studying the determinants of the size and composition of the flows of private capital across countries. It finds that while capital flows tend to go to countries that are safer and have better institutions and financial markets, the share of FDI in total flows is not an indication of good health. On the contrary, countries that are riskier, less financially developed and have weaker institutions tend to attract less capital but more of it in the form of FDI. Hence, interpreting the rising share of FDI as a sign of good health is unwarranted. This is even more so, given that FDI`s recent
The trick is to not blend white and black directly on the palette to get intermediate tones, but, just like in a photo or a print, where the dots are only black ones printed on white paper more or less less thickened, in melting them to our brain in order to make us perceive all the shades of gray. So just paint with just black dots on a white background, or with black and white dots on a gray background to achieve a photorealistic effect. This is also the reason why most of the artists of these currents choose to paint large paintings (usually around two square meters), making it easier for them to see and control the brush strokes. But if one wants to realize a small picture as it should do. Well, there are two solutions, either you buy a high-magnifying monocle or choose to use alternative techniques, which are not of the type with a printing effect, but which allow to obtain similar effects. I do not know canonical methods to paint in this way, but I can illustrate my personal method of ...
The trick is to not blend white and black directly on the palette to get intermediate tones, but, just like in a photo or a print, where the dots are only black ones printed on white paper more or less less thickened, in melting them to our brain in order to make us perceive all the shades of gray. So just paint with just black dots on a white background, or with black and white dots on a gray background to achieve a photorealistic effect. This is also the reason why most of the artists of these currents choose to paint large paintings (usually around two square meters), making it easier for them to see and control the brush strokes. But if one wants to realize a small picture as it should do. Well, there are two solutions, either you buy a high-magnifying monocle or choose to use alternative techniques, which are not of the type with a printing effect, but which allow to obtain similar effects. I do not know canonical methods to paint in this way, but I can illustrate my personal method of ...
S. 2160. A bill to establish a pilot program under which the Chief of the Forest Service may use alternative dispute resolution in lieu of judicial review of certain projects. In GovTrack.us, a database of bills in the U.S. Congress.
The Personal Vehicles Initiative (PVI) encourages and assists motorists to buy, drive and maintain their vehicles in energy-efficient ways that save fuel and money, and emphasizes how such efforts also reduce vehicle emissions. Its main tool is the Auto$mart Guide, which offers information and tips on purchasing, operating and maintaining personal vehicles. The program also provides resource materials to driver educators for fuel-efficiency training to novice drivers and provides Web-based communications tools that support and encourage the development of new initiatives of local governments, industry and associations to promote fuel efficiency. PVI also offers information on opportunities to use alternative fuels. ...
If youve had some or all of your larynx removed (laryngectomy), its likely that youll need to spend one or two days in an intensive care unit until youve recovered.. You wont be able to eat until your throat has healed, which for most people takes at least a week or two. While your throat heals, youll need to be fed through a tube thats passed through your nose and into your stomach. If youve had all of your larynx removed (total laryngectomy), you wont be able to speak normally, because you will no longer have vocal cords. A number of techniques can be used to replicate the functions of your vocal cords (see below), although they can take weeks or months to learn.. Therefore, its likely that youll need to use alternative methods of communicating, such as using a pen or paper, during the first few weeks or months after surgery. This can be a frustrating experience - the loss of something youve previously taken for granted can be difficult to cope with.. Try to prepare yourself for ...
You may find the connections scripts in my GPRS HOWTO useful, just remember to change the device name, data rates and pppd options as described in this document. Make such that compression is not used on the ppp link. This means using the novj and nobsdcomp pppd options. If you have not configured pppd correctly then it will not be able to negotiate the ppp link to the card. If you create a link between /dev/modem and /dev/ttyUSB0 then all the standard internet connection utilities - chat, wvdial, kinternet and kppp for example can be used to make the ppp link. If you want to keep /dev/modem for the traditional land-line (POTS) modem you can use alternative assignments such as: /dev/usb/ttyACM0 which is not used by my system (SusSE 8.2) but is listed as a possible device by kppp. In which case: ...
A large number of the buildings have tank water supplies and therefore we are hoping that this will mean that there is little or no impact on the water supplies in these buildings, particularly toilets. Some buildings however are likely to be without water once the work commences and occupants will therefore have to use alternative toilet facilities in nearby buildings ...
The ubiquitous presence of anthropogenic chemicals and their transformation products in surface water represents a toxicological concern from both an ecological standpoint and a human perspective as many of these chemicals ...
Animals, Antibodies; Monoclonal/*therapeutic use, CD40 Ligand/*immunology, Cyclosporine/therapeutic use, Fetal Tissue Transplantation/*immunology, Graft Rejection/immunology, Graft Survival/immunology, Immunoglobulins; Intravenous/*therapeutic use, Immunohistochemistry, Immunosuppressive Agents/*therapeutic use, Islets of Langerhans Transplantation/*immunology, Male, Rats, Rats; Inbred Lew, Swine, Tacrolimus/therapeutic use, Transplantation; Heterologous/*immunology ...
In bladder cancer, increased Caveolin-1 (Cav-1) expression and decreased Src expression and kinase activity correlate with tumor aggressiveness. Here, we investigate the clinical and functional significance if any, of this reciprocal expression in bladder cancer metastasis. We evaluated the ability of tumor Cav-1 and Src RNA and protein expression to predict outcome following cystectomy in 257 patients enrolled in two independent clinical studies. In both, high Cav-1 and low Src levels were associated with metastasis development. We overexpressed or depleted Cav-1 and Src protein levels in UMUC-3 and, RT4 human bladder cancer cells and evaluated the effect of this on actin stress fibers, migration using transwells and lung metastasis following tail vein inoculation. Cav-1 depletion or expression of active Src in metastatic UMUC-3 cells decreases actin stress fibers, cell migration and metastasis, while, Cav-1 overexpression or Src depletion increased the migration of non-metastatic RT4 cells. ...
Video articles in JoVE about carrier proteins include Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins, Reconstitution of a Kv Channel into Lipid Membranes for Structural and Functional Studies, Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity, A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening, Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-Cut Lung Slices.
Price et al. cleverly circumvent this by looking in the recently admixed African American population. African Americans have on average 20% European ancestry and 80% African ancestry. Because this admixture is recent, there are only a few generations of recombination and so the genome of an African American can be thought of as a mosaic made up of big blocks of alternating African and European ancestry. So at any location in the genome African Americans differ in whether they have locally inherited 0, 1 or 2 chromosomes from African ancestors. African Americans also vary in their genome-wide admixture proportion. Price et al. use this fact, to look at trans effects ancestry, by looking at the correlation between genome-wide ancestry proportion and the expression level of genes. They contrast this to the effect of cis ancestry (i.e. 0,1, or 2 African alleles at a site), to obtain an estimate of the variance explained by cis and trans effects. Somewhat surprisingly (at least if you read mostly ...
Price et al. cleverly circumvent this by looking in the recently admixed African American population. African Americans have on average 20% European ancestry and 80% African ancestry. Because this admixture is recent, there are only a few generations of recombination and so the genome of an African American can be thought of as a mosaic made up of big blocks of alternating African and European ancestry. So at any location in the genome African Americans differ in whether they have locally inherited 0, 1 or 2 chromosomes from African ancestors. African Americans also vary in their genome-wide admixture proportion. Price et al. use this fact, to look at trans effects ancestry, by looking at the correlation between genome-wide ancestry proportion and the expression level of genes. They contrast this to the effect of cis ancestry (i.e. 0,1, or 2 African alleles at a site), to obtain an estimate of the variance explained by cis and trans effects. Somewhat surprisingly (at least if you read mostly ...
Biological evaluation performed on the active substance confirmed no skin irritation or sensitization potential. A slight toxicity potential for the material extract has been revealed under the test conditions in cytotoxicity test; this potential does not manifest itself in the overall local skin reaction in vivo, and can in contrast act as an initiator of healing processes. Very low systemic toxicity (LD50 greater than 5 g per kg body weight for small animals) and no adverse effects at multiple overdosing are observed, as compared with typical dosage of less than 1 g per ...
Figura 5 Estudi histològic comparatiu del tendó sa (A) i el lesionat (B). El tendó lesionat presenta degeneració de lestructura del col·lagen al lloc de la punció (*).. Discussió. La troballa principal daquest estudi fou demostrar la similitud de les alteracions estructurals del tendó rotular de les rates tractat amb col·lagenasa, caracteritzat per la desorganització de les fibres de col·lagen i estructures adjacents, respecte a la tendinopatia rotular observada en la clínica dels humans. Aquests resultats suggereixen que ladministració duna única dosi de col·lagenasa infiltrada mitjançant ecografia guiada és eficaç per a reproduir exactament els canvis estructurals en la integritat de la regió proximal del tendó rotular de la tendinopatia rotular humana.. Per primera vegada, es generà un model animal que imita la degeneració del teixit tendinós en el lloc anatòmic més comú observat en la tendinopatia rotular humana. Shan desenvolupat altres models animals de ...
More than eight years ago, REACH entered into force with the objectives of generating information on chemicals in order to allow for better protection of human health and the environment whilst enhancing competitiveness and innovation. In this period, EU REACH - Registration, Evaluation, Authorisation and restriction (the silent r in the acronym) of CHemicals - Regulation (1) has made a significant impact both in terms of immediate costs to industry and volume of information generated consequently. Registration is often considered to be the most resource demanding aspect, in part, because of the significant data requirements legal entities can be obliged to meet. The complexity of the Regulation coupled with unforeseen issues and dissen ...
Use freetext template and delete/add elements as appropriate. Enter any details that could be relevant for evaluating this study summary or that are requested by the respective regulatory programme. Consult the programme-specific guidance (e.g. OECD HPVC, Pesticides NAFTA or EU REACH) thereof.. Note that any information that can be claimed confidential should be included in the subsequent field Confidential details on test material.. Explanations:. - Name of test material (as cited in study report): only if different from any other identifiers provided in the preceding fields.. - Molecular formula (if other than submission substance): specify. - Molecular weight (if other than submission substance): specify. - Smiles notation (if other than submission substance): provide if available. - InChl (if other than submission substance): provide if available. - Structural formula attached as image file (if other than submission substance): see Fig.: only if different from submission substance. ...
ArcticZymes AS is pleased to announce the launch of HL-dsDNase Glycerol-free Triton FREE. This launch is a continuing step towards maintaining a completely EU REACH compliant product portfolio after Triton X-100 becomes subject to authorisation in January 2021. The convenient glycerol-free formulation is suitable for lyophilization and automated processes. The new formulation offers the same advantages as HL-dsDNase, such as strong preference for double stranded DNA and heat inactivation at low temperatures ...
While mesothelioma presently has no cure, several standard treatments are available that can help reduce pain and improve the patients quality of life. However, patients may also use alternative methods, which are usually based on Eastern medicine, as well as special diets and natural supplements. The main forms are acupuncture, massage, mind-body therapy, herbal supplements, and chiropractic care.. While it may not seem that using these therapies is common, it actually is. Statistics indicate that more 70 percent of people diagnosed with cancer use alternative treatments. This is because alternative therapies help reduce mesothelioma symptoms and relieve pain without the side effects of chemotherapy and radiation. When combined with a balanced diet and regular exercise, alternative therapies can improve quality of life though improved mood, circulation, and functionality.. ...
Patients planned to undergo peripheral nerve repair after traumatic nerve injury with either no gap (group 1) or with a critical sized defect (,5mm, group 2) of the finger providing written informed consent to this investigation will be randomised in two groups:.. Group 1: nerve repair with no gap Group 1a (standard): Epineural Suture Group 1b (experimental): Epineural Suture and Fibrin Wrap Group 2: Nerve repair with a critical sized (,5mm) defect Group 2a (standard): Epineural suture and autologous nerve transplantation from lateral antebrachial cutaneous nerve (LACN) Group 2b (experimental): Epineural suture and Fibrin Conduit. In all groups an epineural suture will be performed (suture enhancement). The outcome of fibrin enwrapment and fibrin conduit will be compared to the standard treatment option to date (direct nerve repair and autologous nerve graft, respectively). Randomization will be performed using a computer-base algorithm (www.randomizer.at). Ambulatory follow up of patients is ...
Semantic Scholar extracted view of Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1317 Islet Xenotransplantation An Experimental Study of Barriers to Clinical Transplantation by Peter N. Schmidt
The aim of the IATA is to replace in vivo tests with in vitro tests. However one in vitro method alone may be no sufficient to conclude on the absence of skin sensitisation potential of chemicals. Therefore, the integrated approach of the IATA concentrates on three key events of the skin senitising AOP (direct protein binding, keratinocyte activation and dendritic cell activation) for the assessment of skin senitising properties of chemicals. The first key event in skin sensitisation initiation is the direct protein binding. In an In chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA) according to OECD Guideline 442C, the reactivity and sensitizing potential of2-isobutyl-4-vinyl-1,3-dioxolane were determined.Solutions of the test item were successfully analysed by the validated DPRA analytical method in both cysteine and lysine containing synthetic peptides. Test item and controls were incubateted for at least 22 h at 25 °C prior to analysis. The concentration of cysteine and ...
As the Lead Registrant for three niobium products, CBMM provides test reports and additional information to the public in compliance with EU REACH requirements. Learn more about the REACH initiative and access test reports here.
There have been concerns raised about the possible side effects resulting from the exposure to amalgam restorations due to the risk of mercury being released into the body. Mercury is widely understood to be extremely toxic to the human body. Mercury can be absorbed through soft tissue (such as in the mouth), or inhaled as mercury vapour.1. In Norway, dentists have in fact been banned from using mercury in fillings, but are instead required to use alternative filling materials (e.g. composite, porcelain, Glass Ionomer) while other European countries such as Denmark and Sweden are actively phasing down amalgam. Amalgam has been banned both for its negative effect on the environment and the toxicity to human health. These countries also impose strict laws about the disposal of unused mercury to ensure it is safely removed.2. ...
TROLLIP, G S et al. Vasectomy under local anaesthesia performed free of charge as a family planning service: complications and results. SAMJ, S. Afr. med. j. [online]. 2009, vol.99, n.4, pp.238-242. ISSN 2078-5135.. OBJECTIVE: To evaluate the safety and efficacy of vasectomy performed under local anaesthesia by junior doctors at a secondary level hospital as part of a free family planning service. METHOD: Men requesting vasectomy were counselled and given written instructions to use alternative contraception until two semen analyses 3 and 4 months after vasectomy had confirmed azoospermia. Bilateral vasectomy was performed as an outpatient procedure under local anaesthesia by junior urology registrars. Statistical analysis was performed using the Mann-Whitney, Kruskal-Wallis, Fishers exact or Spearmans rank correlation tests as appropriate. RESULTS: Between January 2004 and December 2005, 479 men underwent vasectomy at Karl Bremer Hospital, Western Cape, South Africa; their average age was ...
I have been taking vicoprofen (hydrocodone & ibuprofen) for several years. I take 1-2 per day. That is enough to take the edge off of the pain. I mainly take it for my back but it helps with the fibro pain, also. I know many doctors are trying to back off prescribing opioids, but some people really cant function well without it. I, thankfully, have a great doctor that knows in some cases, opioids are necessary. I dont take as much as many people, but most days, its the only way I can go to work and actually live (not just survive). That being said, I use alternative methods to cope, also. I have discovered that sunlight helps my pain a huge amount. I also use massage, chiropractic care, memory foam mattress, and supplements. All of this combined with the meds, allows me to work, be an involved mother, and (I hope) a good wife ...
Health Insurance Off the GridHealth Insurance Off the Grid A Wonderful Way To Use Alternative Medicine and Save Money on Insurance ...
Cell Transplantation publishes original, peer-reviewed research and review articles on the subject of cell transplantation and its application to human diseases. To ensure high-quality contributions from all areas of transplantation, separate section editors and editorial boards have been established. Articles deal with a wide range of topics including physiological, medical, preclinical, tissue engineering, and device-oriented aspects of transplantation of nervous system, endocrine, growth factor-secreting, bone marrow, epithelial, endothelial, and genetically engineered cells, among others. Basic clinical studies and immunological research papers are also featured. To provide complete coverage of this revolutionary field, Cell Transplantation will report on relevant technological advances, and ethical and regulatory considerations of cell transplants. Cell Transplantation is now an Open Access journal starting with volume 18 in 2009, and therefore there will be an inexpensive publication ...
Maikawa, C.L., Weichenthal, S., Wheeler, A.J., Dobbin, N., Smargiassi, A., Evans, G.J., Liu, L., Goldberg, M.S., Godri Pollitt, K.J. (2016) Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma. Environmental Health Perspectives. 124(10):1616-1622.. Godri Pollitt, K.J., Maikawa, C.L., Wheeler, A.J., Weichenthal, S., Dobbin, N., Liu, L., Goldberg, M.S. (2016) Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children. Environmental Health. 15:94.. Weichenthal, S., Lavigne, E., Evans, G.J., Godri Pollitt, K.J., Burnett, R.T. (2016) PM2.5 and Emergency Room Visits for Respiratory Illness: Effect Modification by Oxidative Potential. American Journal of Respiratory and Critical Care Medicine. In Press.. Maikawa, C.L., Zimmerman, N., Rais, K., Shah, M., Hawley, B., Pant, P., Jeong, C.-H., Delgado Saborit, J.M., Volckens, J., Evans, G.J., Wallace, J.S., Godri Pollitt, K.J. (2016) Murine precision-cut lung slices exhibit acute ...
Ex-vivo precision-cut lung slices are perhaps the most complex non-animal model available to assess pulmonary injury. PCLS are created from donor tissues obtained in a clinical setting and are created and maintained at IIVS using our custom PCLS culture system. The tissue offers an advantage over other models since it contains all lung cell types present in the tissue at the time of slicing. Further, it retains the native architecture of the lung - including small airways and respiratory parenchyma. PCLS have been maintained for many weeks and demonstrate changes not shown in other complex models of the lung. Acute (including robust cytokine responses, loss of viability, etc.) and chronic (increases in activated macrophage staining, collagen deposition, tissue remodeling) toxicities can be monitored following test article-exposures. PCLS have also been used to show no effect level and to identify drug concentration-specific reversibility of inflammatory marker expression - a key element in ...
Doctors give trusted, helpful answers on causes, diagnosis, symptoms, treatment, and more: Dr. Marquis on what is the best treatment for scalp defect in newborn: A skin defect is occasionally found on the scalp of newborns & may be finger tip sized or as big as a grapefruit in diameter. The small defects usually gradually become smaller with age & simple cleaning & coverage with antibiotic ointment will prevent complications. Over sized defects may overly an enlarged soft spot & a protective helmet & consultation with a plastic surgeon is in order.
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LYOPHILIZED PLATELET LYSATES | LYOPHILIZED PLATELET LYSATES | FLOWABLE TISSUE MATRICES | Zinc Phosphate Complex | DRUG BASED ON MAGHEMITE FOR SIMULTANEOUS REDUCTION OF GASTROINTESTINAL SODIUM RESORPTION AND PHOSPHATE RESORPTION |
Lux gold heart and roses hoop earrings. 18K Gold plated Lightweight Latch back hoops Nickel safe - EU Reach & US PROP 65 compliant Base: 80% Brass / 20% Stainless steel Hoops measure 15mm. Total earring length 64mm
Sar Hadd (Persian: سرحد‎, also Romanized as Sar Ḩadd and Sarḩad; also known as Sarḩad-e Bālā)[1] is a village in Alqurat Rural District, in the Central District of Birjand County, South Khorasan Province, Iran. At the 2006 census, its population was 173, in 47 families.[2]. ...
Evaluation of Phototoxic and Skin Sensitization Potentials of PLA2-Free Bee Venom. . Download books free in pdf. Online library with books, university works and thousands of documents available to read online and download.
N-nitroso compounds (NOCs) may be implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated. Because it was previously demonstrated that nitrosamines and nitrosamides, representing two classes of NOC, induce distinct gene expression effects in colon cells that are particularly related to oxidative stress, we hypothesized that different radical mechanisms are involved. Using electron spin resonance spectroscopy, we investigated the radical-generating properties of genotoxic NOC concentrations in human colon adenocarcinoma cells (Caco-2). Cells were exposed to nitrosamides (N-methyl-N′-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea) or nitrosamines (N-nitrosodiethylamine, N-nitrosodimethylamine, N-nitrosopiperidine, and N-nitrosopyrrolidine). Nitrosamines caused formation of reactive oxygen species (ROS) and carbon-centered radicals, which was further stimulated in the presence of Caco-2 cells. N-methyl-N-nitrosourea exposure resulted in a ...
We conducted a survey in 2001 that investigated Illinois otolaryngologists, audiologists, hearing aid dealers, and family practitioners knowledge and perceptions of alternative medicine related to the treatment of hearing or ear problems. Respondents were asked to rate their familiarity with a number of proposed home remedies, including the use of olive oil, sweet oil, castor oil, steam, cottonballs, smoke, Mentholatum, vinegar, rubbing alcohol, sardine oil, warm urine, tobacco juice, ear candling/coning, hot onions, hot candle wax, molasses, garlic juice, hair dryers, breast milk, and aloe. Additional questions included requesting more information about the age group, race or culture, and geographical location of patients who reportedly use alternative medicine; formal or informal training received by the professionals; and the advice given to their patients ...
Like ISA-TAB, ISA-TAB-Nano provides fields for entering and referencing terms selected from ontologies and standard terminologies. The ontologies are available at BioPortal (http://www.bioontology.org), which is maintained by the National Center for Biomedical Ontologies. Though the investigator may use alternative ontology and vocabulary sources, the ability to evaluate and share data require that all parties have access to those being used (they should be available to the investigators). All terms and fields used in this standard utilize the NCI EVS (http://evs.nci.nih.gov) and NanoParticle Ontology elements.. NanoParticle Ontology (NPO) [http://www.nano-ontology.org] is an ontology that is designed and developed within the framework of the Basic Formal Ontology (BFO) and implemented in the ontology web language (OWL). It is being developed to represent the knowledge underlying the description, preparation, and characterization of nanomaterials. NPO development began with the representation of ...
Like ISA-TAB, ISA-TAB-Nano provides fields for entering and referencing terms selected from ontologies and standard terminologies. The ontologies are available at BioPortal (http://www.bioontology.org), which is maintained by the National Center for Biomedical Ontologies. Though the investigator may use alternative ontology and vocabulary sources, the ability to evaluate and share data require that all parties have access to those being used (they should be available to the investigators). All terms and fields used in this standard utilize the NCI EVS (http://evs.nci.nih.gov) and NanoParticle Ontology elements.. NanoParticle Ontology (NPO) [http://www.nano-ontology.org] is an ontology that is designed and developed within the framework of the Basic Formal Ontology (BFO) and implemented in the ontology web language (OWL). It is being developed to represent the knowledge underlying the description, preparation, and characterization of nanomaterials. NPO development began with the representation of ...
After Cuba and the United States ended all diplomatic relations in 1961, the Soviet Union became Cubas primary supplier of medical equipment and medicines. The Soviet Union provided 94 percent of Cubas imports of medical equipment in 1961-1988. After the collapse of the Soviet Union, Cubas imports of medical equipment and medicines dropped dramatically. During the worst part of the economic crisis of the 1990s, Cuba had a severe lack of medicines. The supply of raw materials required to produce 85 percent of all drugs consumed in Cuba was halted with the collapse of the Soviet Union, resulting in the lack of 300 medicines (Mesa-Lago, 2000, 324). MINSAP began directing physicians to conserve and control the existing medicines for the neediest. The government also resorted to the use of alternative medicines. Because Cubans do not have a strong traditional reliance of herbal medicine, it was not an easy task to persuade the population to use alternative medications (Barrett 1993, 3).. The oil ...
Member of the Fatwa and Legislation Department Ajeel Al-Nashmi yesterday issued a statement in which he said that the KD 25 billion loan the government plans to obtain would be haram and the excuse made for getting it to cover budget deficits is unacceptable. Nashmi added that he rejects this loan the way he did with previous state transactions involving usury, which is haram (forbidden) in Islam. He added that the KD 25 billion loan will involve usury and cannot be accepted to cover budget deficits. "Allah has blessed us with a luxurious life and kept us safe…usury is a denial and disbelief in such blessings," he explained, warning that some actions can lead to catastrophes. He also suggested that economists use alternatives such as Islamic bonds and sukuk, which had already made $65 billion in 2017. Meanwhile, the Central Bank of Kuwait had announced yesterday latest stock and "tawarruq" issue at a total value of KD 240 million ($792 million) valid for three months, at a two percent ...
Friday, May 15, 2015 (Halifax, NS) - Halifax Regional Municipality is advising residents and motorists work will begin on Tuesday (May 19) to extend the natural gas main on Herring Cove Road between Arthur and Levis streets; and on Dentith Road between Herring Cove and Old Sambro roads. For the work on Dentith Road, two lanes of traffic (one in each direction) will be maintained at all times. On Herring Cove Road, two lanes are expected to be maintained for most of the work. Any required periods of stop-and-go traffic will take place outside the peak hours of 7 a.m. to 9 a.m. and 4 p.m. to 6 p.m. The pipe installation is expected to take approximately five weeks, with permanent restoration to follow.. Heritage Gas has plans for further work in the area as part of this project. An update will be issued closer to the start of the next phase of the project. Motorists should expect delays and are asked to use alternative routes whenever possible.. Heritage Gas and the municipality apologize in ...
Engineering bacteria for measuring chemicals of environmental or toxicological concern (bioreporter bacteria) has grown slowly into a mature research area. Despite many potential advantages, current bioreporters do not perform well enough to comply with environmental detection standards. Basically, the reasons for this are the lack of engineering principles in the detection chain in the bioreporters. Here, we dissect critical steps in the detection chain and illustrate how bioreporter design could be improved by mutagenizing specificity and selectivity of the sensing and regulatory proteins, by newer expression strategies and application of different signalling networks. Furthermore, we describe how redesigning bioreporter assays with respect to pollutant transport into the cells and application of other detection devices can decrease detection limits and increase the speed of detection. ...
Combination therapy of PDE4 inhibitors and anticholinergics induces bronchoprotection in COPD. Mechanical forces that arise during bronchoconstriction may contribute to airway remodeling. Therefore, we investigated the impact of PDE4 inhibitors and anticholinergics on bronchoconstriction-induced remodeling. Because of the different mechanism of action of PDE4 inhibitors and anticholinergics, we hypothesized functional interactions of these two drug classes. Guinea pig precision-cut lung slices were preincubated with the PDE4 inhibitors CHF-6001 or roflumilast and/or the anticholinergics tiotropium or glycopyorrolate, followed by stimulation with methacholine (10 μM) or TGF-β1 (2 ng/ml) for 48 h. The inhibitory effects on airway smooth muscle remodeling, airway contraction, and TGF-β release were investigated. Methacholine-induced protein expression of smooth muscle-myosin was fully inhibited by CHF-6001 (0.3-100 nM), whereas roflumilast (1 µM) had smaller effects. Tiotropium and ...
Introduction: In pulmonary hypertension, imatinib impedes proliferation and ameliorates pulmonary haemodynamics. However, the relaxant potential of imatinib is virtual unknown. Aims and objectives: We wanted to elucidate whether and how imatinib may modulate the tone of pulmonary arteries (PAs) and pulmonary veins (PVs). Methods: Imatinib-induced relaxation was studied by videomicroscopy in precision-cut lung slices (PCLS) from humans and guinea pigs (GPs); baseline luminal vessel area was defined as 100%. Intracellular cAMP was measured by ELISA and imatinib-induced changes of pre- and postcapillary resistances were studied in the isolated perfused lung (GP). Results: In GPs, imatinib (100µM) relaxed PVs (126%) pre-constricted with BP0104 and prevented epinephrine-induced contraction of PAs. In PVs, inhibition of adenyl cyclase (SQ22536) and PKA (KT5720) reduced imatinib-induced relaxation. Conversely, imatinib increased cAMP. Further, inhibition of KATP-channels (glibenclamide), ...
The skin sensitization potential of Alkyl dimethyl hydroxyethyl ammonium chloride was assessed in four independent HRIPT (human repeat insult patch) studies. The test item (in a detergent matrix or alternativ as aqueous solution (w/v)) was exposed on patches to the skin of volunteers in preparation concentrations of at least 0.2 % (w/v) in water up to 0.5 % (w/v) in water. In total 9 inductions were performed. 14 days after final insult patch, treatment sites were challenged and observed 48 and 96 hours after patch. Mild erythema (grade 1) was determined in some of the subjects of the four studies during the challenge. In all four studies there was no evidence that the test item was a sensitizer under the test conditions. ...
I OWA S TATE U NIVERSITY Department of Animal Science Getting GLIMMIX u SAS 9.1 Download add-on (Windows, Unix, Linux) from n n u Supported on a limited number of platforms and platform configurations u SAS 9.2 (available now for most academic sites) An Introduction to Generalized Linear Mixed Models Using SAS PROC GLIMMIX P. Gibbs, SAS Technical Support
Gene engineering, to some, is the most powerful existing tool for life extension. Mutations in certain genes result in up to 10-fold increase in nematode lifespan and in up to 2-fold increase in a mouse life expectancy. Gene therapy represents a unique tool to transfer achievements of gene engineering into medicine. This approach has already been proven successful for treatment of numerous diseases, in particular those of genetic and multigenic nature. More than 2000 clinical trials have been launched to date. Proposals exist to developing a gene therapy that will radically extend lifespan. Genes that promote longevity of model animals will be used as therapeutic agents. Then manipulate not a single gene, but several aging mechanisms simultaneously. A combination of different approaches may lead to an additive or even a synergistic effect, resulting in a very long life expectancy. For this purpose, an animal will be affected by a set of genes that contribute to longevity. In addition, a gene ...
To date, the benefits of scientific medicine are indisputable. Nevertheless, more and more people trust non-traditional methods of treatment. The majority of patients use alternative therapies in addition to conventional. This practice is called complementary, that is "complementary" medicine.. Alternative medicine in Germany is based on a long tradition. More than 60% of the population of this country are not only the methods of scientific medicine, but also non-traditional methods of treatment.. Unlike other countries, in Germany, complementary medicine is generally practiced by doctors with higher medical education. Every doctor has the opportunity to receive additional qualification in the field of science recognized methods of alternative medicine such as naturopathy, homeopathy or acupuncture, and use them in the future for their patients.. German medical specialists who use methods of complementary medicine, we attach great importance to ensuring that this practice had a scientific basis. ...
Alternatives to animal experimentation The in vitro core toxicology unit is studying placental transportation of substances and materials in a laboratory model with fresh placentas from births at the Rigshospitalet (RH). A variety of chemicals, such as pesticides, substances formed during food preparation, biological therapeutics, naturally occurring large biomolecules, as well as nanoparticles are studied in the system. In collaboration with clinicians and pathologists from the RH, the in vitro core unit is elaborating the model and also participating in international validation programs of alternatives to animal experimentation. The vision is, in collaboration with other in vitro toxicology researchers, to create a battery of toxicology tests to minimize the use of experimental animals, which is an action point in the research strategy of the EU. As the research activities of the in vitro core unit involve blood and tissue from participants, ethical issues related to recruitment, feedback and ...
Furfuryl alcohol is considered by the United States Environmental Protection Agency to be a high volume production chemical with over 1 million pounds produced annually. Due to its high production volume and its numerous industrial and consumer uses there is considerable potential for work-related exposure, as well as exposure to the general population, through pulmonary, oral, and dermal routes o
TY - JOUR. T1 - Implications of Transitioning from de Facto to Engineered Water Reuse for Power Plant Cooling. AU - Barker,Zachary A.. AU - Stillwell,Ashlynn S.. PY - 2016/5/17. Y1 - 2016/5/17. N2 - Thermoelectric power plants demand large quantities of cooling water, and can use alternative sources like treated wastewater (reclaimed water); however, such alternatives generate many uncertainties. De facto water reuse, or the incidental presence of wastewater effluent in a water source, is common at power plants, representing baseline conditions. In many cases, power plants would retrofit open-loop systems to cooling towers to use reclaimed water. To evaluate the feasibility of reclaimed water use, we compared hydrologic and economic conditions at power plants under three scenarios: quantified de facto reuse, de facto reuse with cooling tower retrofits, and modeled engineered reuse conditions. We created a genetic algorithm to estimate costs and model optimal conditions. To assess power plant ...
KCNQ (Kv7 family) potassium (K(+)) channels were recently found in airway smooth muscle cells (ASMCs) from rodent and human bronchioles. In the present study, we evaluated expression of KCNQ channels and their role in constriction/relaxation of rat airways. Real-time RT-PCR analysis revealed expression of KCNQ4 , KCNQ5 , KCNQ1 , KCNQ2 , KCNQ3, and patch-clamp electrophysiology detected KCNQ currents in rat ASMCs. In precision-cut lung slices, the KCNQ channel activator retigabine induced a concentration-dependent relaxation of small bronchioles preconstricted with methacholine (MeCh; EC50 = 3.6 +/- 0.3 muM). Bronchoconstriction was also attenuated in the presence of two other structurally unrelated KCNQ channel activators: zinc pyrithione (ZnPyr; 1 muM; 22 +/- 7%) and 2,5-dimethylcelecoxib (10 muM; 24 +/- 8%). The same three KCNQ channel activators increased KCNQ currents in ASMCs by two- to threefold. The bronchorelaxant effects of retigabine and ZnPyr were prevented by inclusion of the KCNQ ...
How much is at stake? There is no easy answer, but one important indicator of how this animal research complex continues to grow is how much the National Institutes of Health (NIH) spends on animal research. Although it is not possible to disaggregate the budgets to identify money spent on animal research for individual projects, it is possible to get a sense through Institutional Animal Care and Use Committee information. Reliable government sources have informed NAVS that approximately 47% of NIH-funded grants have an animal research-based component. This number has been fairly steady over the past ten years. In 2015, the NIH budget of almost $22 billion resulted in well over $10 billion in funding for projects that included animal experimentation.. Obviously the salaries of researchers and technicians who carry out animal experiments, as well as income from patents for the drugs and medical devices they develop, provide financial incentives and career advancement to conduct research on ...

Petition · Stop Animal Testing: Replace Animals in Research with Non-Animal Alternative Methods · Change.orgPetition · Stop Animal Testing: Replace Animals in Research with Non-Animal Alternative Methods · Change.org

Alternatives for Testing Alternatives to the use of animals in toxicity testing include replacing animal tests with non-animal ... C B needs your help with "Stop Animal Testing: Replace Animals in Research with Non-Animal Alternative Methods". Join C and ... C B needs your help with "Stop Animal Testing: Replace Animals in Research with Non-Animal Alternative Methods". Join C and ... Stop Animal Testing: Replace Animals in Research with Non-Animal Alternative Methods. ...
more infohttps://www.change.org/p/stop-animal-testing-replace-animals-in-research-with-non-animal-alternative-methods?javascript=false

experimental animalsexperimental animals

FRAME, and has been a key scientific journal in the field of laboratory animal alternatives for more than 30 years. Circulated ... It covers the latest research relating to alternatives to the use of laboratory animals. Click here to learn about FRAME ... Statistics of Scientific Procedures on Living Animals Great Britain 2015 - Highlighting an Ongoing Upward Trend in Animal Use ... Rita Seabra 2017-04-24T11:53:00+00:00 Tags: dogs, experimental animals, genetically-altered animals, mice, primates, UK ...
more infohttp://www.atla.org.uk/tag/experimental-animals/

Animal Welfare Policies - USPCAAnimal Welfare Policies - USPCA

The USPCA is opposed to the unnecessary use of animals in any course which either causes suffering or for which alternatives to ... Further they cannot oppose uses of animals for which there are no alternatives but which may cause pain, suffering or distress ... 6.3 Performing Animals. 6.3.1. The USPCA is opposed to the use of animals for any form of entertainment where distress or ... 7.0 Animals and Education. 7.1 General Considerations. 7. 1.1. The USPCA is opposed to the use of animals for education where ...
more infohttp://uspca.co.uk/animal-welfare-policies/

Food Companies Step Up Farm Animal Welfare Measures - The Cattle SiteFood Companies Step Up Farm Animal Welfare Measures - The Cattle Site

... according to the latest Business Benchmark on Farm Animal Welfare (BBFAW) report, published on Monday. ... Food companies are paying more and more attention to animal welfare within their supply chains, ... Waste Reduction Tech, Meat Alternatives and Yield Optimisation at FoodBytes! London 2019. 13 November 2019 ... GLOBAL - Food companies are paying more and more attention to animal welfare within their supply chains, according to the ...
more infohttp://thecattlesite.com/news/50743/food-companies-step-up-farm-animal-welfare-measures/

Keynote: Applying Principles of Biosafety in Laboratory Animal FacilitiesKeynote: Applying Principles of Biosafety in Laboratory Animal Facilities

... Presented at the Laboratory Animal Sciences Virtual ... Continuous Professional Development (CPD) in Laboratory Animal Science, a continuous improvement in animal welfare and science ... Past-President of the American College of Laboratory Animal Medicine (ACLAM) and serves on the United States Animal Health ... including development of research animal models and providing veterinary care and research support to animals at biosafety ...
more infohttps://www.labroots.com/webinar/keynote-applying-principles-of-biosafety-in-laboratory-animal-facilities

CCA Action News | September 10, 2012CCA Action News | September 10, 2012

Alternatives: There are three main alternatives. The best option is to make cow culling decisions while these animals are still ... These animals must not be transported.. Do not transport these animals until the animal has been treated and /or recovered. If ... Temple Grandin indicated that of the many animals filmed, one animal was improperly stunned in the video. That context does not ... Animals that are not fit for transport may be euthanized and disposed of on farm instead. There are also companies in some ...
more infohttp://www.cattle.ca/action-news/2012/09-10-12.html

International Groups Unite to Develop Animal AlternativesInternational Groups Unite to Develop Animal Alternatives

Global efforts to promote alternatives to animal testing were united at the April 27, 2009, meeting in Brussels via the signing ... The European Commission announced that global efforts to promote alternatives to animal testing were unified at the April 27, ... International Groups Unite to Develop Animal Alternatives. April 30, 2009 , Contact Author , By: Katie Schaefer. ... Reducing animal testing, both out of concern for animal welfare and ethical issues, and protecting consumer safety are two ...
more infohttp://www.cosmeticsandtoiletries.com/regulatory/region/europe/44057287.html

Lab animal alternative yields major discovery | ISRAEL21cLab animal alternative yields major discovery | ISRAEL21c

... designed to end animal testing, reveals groundbreaking information about a common pain reliever. ... Lab animal alternative yields major discovery. Israeli-German bionic liver-on-chip device, designed to end animal testing, ... Nissim Benvenisty as an alternative to animal testing for various human genetic diseases and pharmaceuticals for "orphan ... are restricting the use of live animals in product safety tests. And scientists are increasingly concerned that animal studies ...
more infohttps://www.israel21c.org/lab-animal-alternative-yields-major-discovery/

General Assembly Discusses Endocrine Disruptors, Nano, Animal Alternatives and MoreGeneral Assembly Discusses Endocrine Disruptors, Nano, Animal Alternatives and More

Animal Testing Alternatives. Due to the 7th Amendment of the Cosmetics Directive, animal testing will be banned starting March ... Horst Wenck, PhD, chair of Cosmetics Europes Strategic Project Team on Alternatives to Animal Testing, gave highlights on the ... General Assembly Discusses Endocrine Disruptors, Nano, Animal Alternatives and More. July 12, 2012 , Contact Author , By: ... Research on alternative methods started 20 years ago, but some end-points are still challenging. ...
more infohttp://www.cosmeticsandtoiletries.com/networking/eventcoverage/162204605.html?page=3

Lab-animal Alternatives Are the New Guinea Pigs - An Animal Rights Article from all-creatures.orgLab-animal Alternatives Are the New Guinea Pigs - An Animal Rights Article from all-creatures.org

Lab-animal Alternatives Are the New Guinea Pigs - All of Gods creatures have rights, includes both human and non-human animals ... Lab-animal Alternatives Are the New Guinea Pigs. An Animal Rights Article from All-Creatures.org. FROM. Melissa Suran, Medill ... Return to Animal Rights Articles. Read more at Alternatives to Animal Testing, Experimentation and Dissection ... This is the perfect alternative to the use of live animals in surgical training, said Aboud, a neurosurgeon fellow at the ...
more infohttps://www.all-creatures.org/articles/ar-labanimal.html

UCDavis Center for Animal Alternatives - WikipediaUCDavis Center for Animal Alternatives - Wikipedia

UCDavis Center for Animal Alternatives disseminates information on alternatives to animal experiments and provides animal ... Center for Alternatives to Animal Testing Dr Hadwen Trust Official website. ... experimenters with information on the most current methods for improving all aspects of animal care. ...
more infohttps://en.wikipedia.org/wiki/UCDavis_Center_for_Animal_Alternatives

Alternative Animal Health Monitoring Methods | Charles RiverAlternative Animal Health Monitoring Methods | Charles River

... testing options based on the type of animal rack system employed in your vivarium. ... Animal Health Surveillance Toggle menu. * 360 Diagnostics™ Program Overview * Alternative Health Monitoring (e.g., EAD®) Toggle ... Animal Health Surveillance Toggle menu. * 360 Diagnostics™ Program Overview * Alternative Health Monitoring (e.g., EAD®) Toggle ... Animal Health Surveillance * 360 Diagnostics™ Program Overview * Alternative Health Monitoring (e.g., EAD®) * Are you Roxanne ...
more infohttps://www.criver.com/products-services/research-models-services/animal-health-surveillance/alternative-health-monitoring

Regulations for Animal Alternative Testing in the Cosmetic Industry - invitrointlRegulations for Animal Alternative Testing in the Cosmetic Industry - invitrointl

Regulations for Animal Alternative Testing in the Cosmetic Industry. The cosmetic industry is always looking for more ... Pioneers in the development and application of non-animal testing alternatives for irritation and skin toxicity testing. ... Alternative approaches like in-vitro, human tissue and computer models tend to be less expensive and certainly easier to manage ... Previous Previous post: Australias Animal Testing Laws: A Good Start but Still Misses the Mark ...
more infohttps://www.invitrointl.com/wp-content/cache/swift-performance/invitrointl.com/regulations-for-animal-alternative-testing-in-the-cosmetic-industry/desktop/unauthenticated/index.html

Chiropractic<...Chiropractic<...

2017 Alternative Vet. All Rights Reserved.. The owner of this website is a participant in the Amazon Services LLC Associates ... Physiotherapy can be very helpful to injured animals or those with back pain. However, at the AVMC we believe that this should ... This may include Alternative Therapy and may include chiropractic manipulation. If neither is mentioned, yet you feel that you ... This service is also offered for animals in zoos or circuses - a whimsical personal ambition is to perform this on a giraffe! ...
more infohttps://www.alternativevet.org/chiropractic.htm

Animal Testing Alternatives | Foundation for Biomedical ResearchAnimal Testing Alternatives | Foundation for Biomedical Research

Alternatives to Animal Testing and Research. Alternatives to Animal Testing and Research ... As additional alternatives are developed, science will naturally reduce the need and use of animal models. This progression ... A cell culture is not a full living system, like an animal or person, so it doesnt show how a disease or drug works throughout ... Computer models and cell cultures, as well as other adjunct research methods, reduce the number of animals used. But there is ...
more infohttps://fbresearch.org/biomedical-research/alternatives-to-animal-testing-and-research/

Alternatives to animal use | University of CambridgeAlternatives to animal use | University of Cambridge

These are the principles of reduction, refinement and replacement of animals in research (the 3Rs), which ... We only use animals in research where there are no alternatives and try to limit the number of animals used in research, either ... improving our experimental techniques or through the development of technologies or techniques that can replace the animals ... We only use animals in research where there are no alternatives and try to limit the number of animals used in research, either ...
more infohttps://www.cam.ac.uk/research/research-at-cambridge/animal-research/about-our-animal-research/which-types-of-animals-do-we-use/alternatives-to-animal-use

Why Can Only Humans be Murdered? What About Non-Human Animals? | AlternativeWhy Can Only Humans be Murdered? What About Non-Human Animals? | Alternative

Its well known that the language we use to refer to nonhuman animals (animals) can be used to hide or sanitize the often ... www.earth-heal.com/news/news/55-human-animal-bonding-and-communication/3201-murder-of-animals.html. We encourage you to Share ... Whats important here is that the word "murder" is used in the print edition to refer to humans killing nonhuman animals. ... kill healthy animals, usually "in the name of humans." Its about time these polite words are changed to the harsher word, ...
more infohttp://beforeitsnews.com/alternative/2017/02/why-can-only-humans-be-murdered-what-about-non-human-animals-3479418.html

Alternatives to animal testing | News | CORDIS | European CommissionAlternatives to animal testing | News | CORDIS | European Commission

Background Animals are still used abundantly to assess the efficacy and safety of cosmetics, medicines, food additives,...,FP4- ... Human health and animal welfare both stand to gain from the development of new in vitro toxicology tests, based on cultured ... Alternatives to animal testing. Human health and animal welfare both stand to gain from the development of new in vitro ... In September 1999, the Centre was the principal organiser of the 3rd World Congress on Alternatives and Animal Use in the Life ...
more infohttps://cordis.europa.eu/news/rcn/14402_en.html

Plan Expedites Alternatives To Animal Testing | EmaxHealthPlan Expedites Alternatives To Animal Testing | EmaxHealth

... new alternative test methods can be developed that will benefit animal welfare by reducing, refining, and replacing animal use ... Alternative test methods are those that accomplish one or more of the 3Rs of reducing the number of animals used in testing, or ... and alternative testing methods that protect human and animal health and the environment. ... said a high priority for ICCVAM will be to focus on evaluating alternatives to test methods that use a large number of animals ...
more infohttps://www.emaxhealth.com/95/20760.html

Cell-based alternative to animal testingCell-based alternative to animal testing

... 08.08.2011. European legislation restricts animal testing within the pharmaceutical ... Our lab-based alternative to animal testing, although in an early stage of production, is faster, out-performs present ... 1. A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests Henrik ... Animal Testing »BioMed »Dermatitis »Genomics »Hypoallergenic »human cell »low immunogenicity »sensitizing potency ...
more infohttp://www.innovations-report.com/html/reports/life-sciences/cell-based-alternative-animal-testing-179836.html

First lab-grown epidermis points to animal testing alternativesFirst lab-grown epidermis points to animal testing alternatives

... By Simon Pitman ... New skin test will create "faster and more accurate" alternative to animal testing ... P&G develops first approved non-animal alternative for skin allergy testing ... University said they had come up with a skin testing alternative that promised a faster and more accurate alternative to animal ...
more infohttps://www.cosmeticsdesign-europe.com/Article/2014/04/25/First-lab-grown-epidermis-points-to-animal-testing-alternatives

ALTEX: Alternatives to Animal Experimentation | Directory of Open Access JournalsALTEX: Alternatives to Animal Experimentation | Directory of Open Access Journals

Alternatives to Animal Experimentation in DOAJ. DOAJ is an online directory that indexes and provides access to quality open ... Publishers keywords: in vitro methods, alternatives to animal experiments, toxicology, bioethics. Language of fulltext: ...
more infohttps://doaj.org/toc/1868-596X

Alternatives to animal research in acute lung injury | The BMJAlternatives to animal research in acute lung injury | The BMJ

Alternatives to animal research in acute lung injury BMJ 2014; 349 :g4171 ... Letters Utility of animal research Alternatives to animal research in acute lung injury. BMJ 2014; 349 doi: https://doi.org/ ... Although animal research is not a perfect model of human disease, there are practical and ethical difficulties in proceeding ... Pound and Bracken suggest that all animal research is futile,1 highlighting problems with quality, validity, and reporting. ...
more infohttps://www.bmj.com/content/349/bmj.g4171
  • Animal experimenters face the unavoidable fact that their artificially created "animal model" can never fully reflect the human condition, whereas clinical investigators know that the results of their work are directly relevant to people. (change.org)
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