Alkylating anti-neoplastic agent.
Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).
Any of several BRASSICA species that are commonly called mustard. Brassica alba is white mustard, B. juncea is brown or Chinese mustard, and B. nigra is black, brown, or red mustard. The plant is grown both for mustard seed from which oil is extracted or used as SPICES, and for its greens used as VEGETABLES or ANIMAL FEED. There is no relationship to MUSTARD COMPOUNDS.

Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrug. (1/14)

RHI-betaG-PEG, formed by linking poly(ethylene glycol)-modified beta-glucuronidase to Mab RH1, was employed to examine bystander killing of antigen-negative N1S1 rat hepatoma cells by activation of a glucuronide prodrug (BHAMG) of p-hydroxyaniline mustard (pHAM) at antigen-positive AS-30D rat hepatoma cells. Sequential treatment of cells with 10 microg ml(-1) RH1-betaG-PEG and 20 microM BHAMG was not toxic to N1S1 cells but killed 99% of AS-30D cells. Over 98% of N1S1 cells, however, were killed in mixed populations containing as few as 2% AS-30D cells after identical treatment, demonstrating an in vitro bystander effect. Subcutaneous injection of AS-30D and N1S1 cells in BALB/c nu/nu mice produced solid tumours containing both cells. Uptake of radiolabelled RH1-betaG-PEG in solid AS-30D and mixed AS-30D/N1S1 tumours was 11.6 and 9.3 times greater than a control antibody conjugate 120 h after i.v. injection. Intravenous treatment with RH1-betaG-PEG and BHAMG cured seven of seven nude mice bearing solid s.c. AS-30D tumours and significantly delayed, compared with control conjugate and prodrug treatment, the growth of mixed N1S1/AS-30D tumours with one cure, showing that targeted activation of BHAMG kills bystander tumour cells in vivo.  (+info)

A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells. (2/14)

We describe a novel strategy to increase the selective toxicity of genotoxic compounds. The strategy involves the synthesis of bifunctional molecules capable of forming DNA adducts that have high affinity for specific proteins in target cells. It is proposed that the association of such proteins with damaged sites in DNA can compromise protein function and/or DNA repair resulting in increased toxicity. We describe the synthesis of a bifunctional compound consisting of an aniline mustard linked to the 7alpha position of estradiol. This novel compound can form covalent DNA adducts that have high affinity for the estrogen receptor. Breast cancer cells that express high levels of the estrogen receptor showed increased sensitivity to the cytotoxic effects of the new compound.  (+info)

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures. (3/14)

The efficacy of cancer gene therapy depends critically on "bystander effects" by which genetic modification of tumor cells results in killing of unmodified cells in the local microenvironment. In gene-dependent enzyme-prodrug therapy, expression of a prodrug-activating suicide gene is used to generate a cytotoxic metabolite that diffuses to nontransduced cells. The objective of this study was to develop a physiologically relevant tissue culture model for quantifying bystander effects and to validate the model using as an example the activation of dinitrobenzamide prodrugs (e.g., CB 1954) by Escherichia coli aerobic nitroreductase (NTR). Bystander effects were measured in three-dimensional multilayer cocultures of NTR+ and NTR- cells by determining clonogenic survival curves for both cell types using V79, Skov3, or WiDr as parental cell lines. Bystander killing by CB 1954 was much more efficient in multilayers than monolayers at equivalent cell:medium ratios, whereas the chloromustard analogue of CB 1954 showed even greater efficiency. For a series of dinitrobenzamides, bystander killing in multilayers showed a positive correlation with prodrug lipophilicity and also correlated with the bystander effect in mixed tumor xenografts grown from the same NTR+ and NTR- WiDr cell lines (r(2) = 0.84; P < 0.001). The multilayer model identified a bromomustard prodrug (SN 24927) with superior therapeutic activity to CB 1954 that provided curative activity against WiDr tumors comprising 1:1 mixtures of NTR+ and NTR- cells. This study demonstrates the utility of the multilayer tissue culture model for quantifying and optimizing bystander effects in tumors and identifies a new lead prodrug for NTR gene-dependent enzyme-prodrug therapy.  (+info)

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT. (4/14)

An important feature of gene-directed enzyme-prodrug therapy is that prodrug activation can provide diffusible cytotoxic metabolites capable of generating a local bystander effect in tumours. Activation of the aziridinyl dinitrobenzamide CB 1954 by E. coli nitroreductase (NTR) provides a bystander effect assumed to be due to the potently cytotoxic 4-hydroxylamine metabolite. We show that there are four cytotoxic extracellular metabolites of CB 1954 in cultures of NTR-expressing tumour cells (the 2- and 4-hydroxylamines and their corresponding amines). The 4-hydroxylamine is the most cytotoxic in DNA crosslink repair defective cells, but the 2-amino derivative (CB 10-236) is of similar potency to the 4-hydroxylamine in human tumour cell lines. Importantly, CB 10-236 has much superior diffusion properties to the 4-hydroxylamine in multicellular layers grown from the SiHa human cervical carcinoma cell line. These results suggest that the 2-amine, not the 4-hydroxylamine, is the major bystander metabolite when CB 1954 is activated by NTR in tumours. The corresponding dinitrobenzamide nitrogen mustard SN 23862 is reduced by NTR to form a single extracellular metabolite (also the 2-amine), which has superior cytotoxic potency and diffusion properties to the CB 1954 metabolites. These results are consistent with the reported high bystander efficiency of SN 23862 as an NTR prodrug in multicellular layers and tumour xenografts.  (+info)

Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents. (5/14)

A series of bifunctional compounds was prepared consisting of 17beta estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to the estrogen receptor. Linker characteristics were pivotal determinants underlying the ability of the compounds to kill selectively breast cancer cells that express the estrogen receptor.  (+info)

Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy. (6/14)

Cancer chemotherapy may be improved by increasing antineoplastic drug specificity for tumor cells. We have synthesized a glucuronide prodrug that can be enzymatically converted to an antineoplastic agent at tumor cells that are able to bind beta-glucuronidase-monoclonal antibody conjugates. The glucuronide prodrug BHAMG, the tetra-n-butyl ammonium salt of (p-di-2-chloroethylaminophenyl-beta-D-glucopyranoside) uronic acid, was 150 times less toxic than the parent drug, N,N-di-(2-chloroethyl)-4-hydroxyaniline, to HepG2 human hepatoma cells and over 1000-fold less toxic than the parent drug to AS-30D rat hepatoma cells in vitro. In the presence of beta-glucuronidase, BHAMG was activated and became as toxic as the parent drug N,N-di-(2-chloroethyl)4-hydroxyaniline. A conjugate (RH1-beta G) was formed by linking beta-glucuronidase to a monoclonal antibody which binds to an antigen expressed on the surface of AS-30D cells. The concentration of BHAMG causing 50% inhibition of AS-30D cellular protein synthesis was reduced over 1000-fold, from greater than 770 microM to less than 0.74 microM after these cells were preincubated with RH1-beta G. Specificity of BHAMG activation at antigen-positive cells was shown by monoclonal antibody RH1 blocking of RH1-beta G conversion of BHAMG to toxic drug and by the inability of BHAMG to be converted to active drug when antigen-negative control cells were preincubated with RH1-beta G. Our results show that the targeted-beta-glucuronidase activation of BHAMG can increase the specificity of chemotherapy for rat hepatoma in vitro and suggest that the targeted activation of glucuronide prodrugs may be useful for cancer therapy.  (+info)

A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug. (7/14)

PURPOSE: Antibody-directed enzyme prodrug therapy is a two-stage treatment whereby a tumor-targeted antibody-enzyme complex localizes in tumor for selective conversion of prodrug. The purpose of this study was to establish optimal variables for single administration of MFECP1, a recombinant antibody-enzyme fusion protein of an anti-carcinoembryonic antigen single-chain Fv antibody and the bacterial enzyme carboxypeptidase G2 followed by a bis-iodo phenol mustard prodrug. MFECP1 is manufactured in mannosylated form to facilitate normal tissue elimination. EXPERIMENTAL DESIGN: Pharmacokinetic, biodistribution, and tumor localization studies were used to test the hypothesis that MFECP1 localizes in tumor and clears from normal tissue via the liver. Firstly, safety of MFECP1 and a blood concentration of MFECP1 that would avoid systemic prodrug activation were tested. Secondly, dose escalation of prodrug was done. Thirdly, the dose of MFECP1 and timing of prodrug administration were optimized. RESULTS: MFECP1 was safe and well tolerated, cleared rapidly via the liver, and was less immunogenic than previously used products. Eighty-fold dose escalation from the starting dose of prodrug was carried out before dose-limiting toxicity occurred. Confirmation of the presence of enzyme in tumor and DNA interstrand cross-links indicating prodrug activation were obtained for the optimal dose and time point. A total of 28 of 31 patients was evaluable for response, the best response being a 10% reduction of tumor diameter, and 11 of 28 patients had stable disease. CONCLUSIONS: Optimal conditions for effective therapy were established. A study testing repeat treatment is currently being undertaken.  (+info)

Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target. (8/14)

 (+info)

to the similar functions with natural enzymes, maturing preparation methods and other advantages compared with natural enzymes. In order to know well about the prodrug activation mediated by MEMs, the cases of practical and potential prodrug activation are listed in Table 2. Although the perfect examples for practical prodrug activation are relative less, ones for potential prodrug activation are more and inspiring. The potential prodrug activation can be classified into two types. In type I, the true MEMs should be completed by loading the naked catalytic cores into the scaffolds. In type II, many perfect MEMs have been used for catalyzing the model molecules, whose catalytic styles just correspond to some practical prodrug activations by natural enzymes. Therefore, these MEMs are greatly potential for practical activation. In order to improve the effectiveness and usability of the prodrug activation mediated by MEMs, some further studies are interesting and essential. First, the exploration of ...
SAN FRANCISCO, Jan. 24, 2011 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases, today announced that combining antibody-directed drug and radionuclide therapeutics for pancreatic cancer improved efficacy in preclinical studies with minimal toxicity. Results from these investigations were presented at the 2011 Gastrointestinal Cancers Symposium.
In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s) into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol), β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose - dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using
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Definition of antibody-directed enzyme prodrug therapy in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is antibody-directed enzyme prodrug therapy? Meaning of antibody-directed enzyme prodrug therapy as a legal term. What does antibody-directed enzyme prodrug therapy mean in law?
Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material. ...
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Visit ChemicalBook To find more Aniline(62-53-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Aniline(62-53-3). At last,Aniline(62-53-3) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
Ive always heard that generally speaking, Aniline finished leathers are superior because they are usually reserved for full grain hides, and also that cheaper leathers would have a white/blue/gray center. But after receiving some samples of Aniline dyed leather from one of the better French tanne...
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The engineered mice were more adept at learning to navigate a water maze and remembering that being in a certain box involves a mild shock. Equally important, Dr. Bibb said, when a situtation changed, such as the water maze being rearranged, the engineered mice were much faster to realize that things were different and work out the new route ...
Check Stock & Buy quality Ezetimibe m-fluoro aniline analog with CAS No: NA with all required spectral data and CoA from Synthink Research Chemicals
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Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Hello Ive been training BJJ about nine months and one of the chokes that for whatever reason I have become somewhat adept at is the Ezekiel from someones guard and the mount and roll technique. I have a question concerning the nature of this choke, It was taught to the class a couple weeks into my training however i rarely see anyone use it even though it seems like its wide open in many occasions. I have used it many times and have had more success with this submission than any others
Saat waktu telah berlalu, berjalan perlahan meninggalkan keadaan pahit kala itu. Saat itulah aku mulai sadar bahwa aku kehilangan dirimu. Lalu mengapa saat-saat itu harus kembali hadir. Mengapa saat-saat itu harus kembali disini, di pikiranku, di nadiku. Aku menghembuskan napas dengan berat. Ini seperti Déjà vu. Kenangan manis dan pahit bersamamu harus kembali terputar. Ini…
TY - JOUR. T1 - Vapor-Liquid Equilibria in the System of Toluene/Aniline, Aniline/Naphthalene, and Naphthalene/Quinoline. AU - Lee, Chang-Ha. AU - Chen, Quen. AU - Mohamed, Rahoma S.. AU - Holder, Gerald D.. PY - 1992/4/1. Y1 - 1992/4/1. N2 - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately correlated with the modified Peng-Roblnson equation of state by using density-dependent mixing rules. The binary interaction parameters and correction factors for the equation of state are reported at each isotherm. The presence of coal-derived solids in these binary systems did not influence any of the binary bubble pressures.. AB - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately ...
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TY - JOUR. T1 - Inhibition of cell proliferation with antibody-targeted liposomes containing methotrexate-γ-dimyristoylphosphatidylethanolamine. AU - Noé, Christine. AU - Hernandez-Borrell, Jordi. AU - Kinsky, Stephen C.. AU - Matsuura, Eiji. AU - Leserman, Lee. N1 - Funding Information: We thank Patrick Machy for helpful discussions,a ndJoan E. Loadera ndG enevievVe ictorero for skilled technical assistance. S.C.K. is a Catherine Kramer Foundation Scientist in Pediatrics.C .N. was supportedb y a scholarship from AssistanceP ublique. J. H.-B. was supported by a fellowship( PosteR ouge)f rom C.N.R.S. This researchw as supportedb y National Instituteso f Health( U.S.A.)g rantA 1-15796(t o S.C.K.) and by institutionalg rants from I.N.S.E.R.M. and from C.,X!.R.S.,~ .~~ grm,.tf roml Associationp ourla Recherches ur le Cancer( to L.L.).. PY - 1988/12/22. Y1 - 1988/12/22. N2 - We have prepared liposomes containing methotrexate-γ-dimyristoylphosphatidylethanolamine (MTX-DMPE liposomes), to which ...
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Prior treatment with any of the following: immunosuppressive therapy (including post stem cell transplant regimens) within 14 days before the first dose of ponatinib; any targeted cancer therapy (including TKIs) within 7 days before the first dose of ponatinib; any other investigational anticancer agents within 30 days or 5 half-lives, whichever is longer, before randomization; any monoclonal antibody-directed anticancer therapy within 5 half-lives of the first dose of ponatinib; any chimeric antigen receptor therapy within 28 days before the first dose of ponatinib; ponatinib ...
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You are viewing an interactive 3D depiction of the molecule n,n-bis(2-chloroethyl)-1,4-benzenediamine (C10H14Cl2N2) from the PQR.
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Membranes are vital barriers by which cells control the flux of molecules and energy between their exterior and interior and also between their various intracellular compartments. While numerous transport systems exist for ions and small molecules, the cytosolic uptake of larger biological molecules and in particular antibody-targeted drugs, is a big challenge. Inducing leakage of the plasma membrane is unfavorable since the target cell specificity mediated by the antibody would likely be lost in this case. After binding and internalization, the antibody drug conjugates reach the endosomes. Thus, enforcing the endosomal escape of anti-tumor toxins without affecting the integrity of other cellular membranes is of paramount importance. Different strategies have been developed in the last decades to overcome endosomal accumulation and subsequent lysosomal degradation of targeted protein-based drugs. In this review we summarize the various efforts made to establish efficient techniques to disrupt the
TY - JOUR. T1 - Intermediates in the reaction of aniline with formaldehyde catalyzed by acids. AU - Bochkarev, V. V.. AU - Soroka, L. S.. PY - 2000/5/1. Y1 - 2000/5/1. N2 - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the semiempirical MNDO method. According to the calculation results, protonated N-(hydroxymethyl)aniline and ortho-, meta-, and paraσ-complexes are formed through the ion-dipole complex. Further transformations of these intermediates, which determine the structure of the final products, depend on the possibility of proton abstraction from the σ-complexes with formation of a quinonimine structure, as well as on the lability of the hydroxymethyl group in the protonated amino alcohol.. AB - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the ...
The carbocyclic nucleosides, represented by the prototype molecule, CBV, are novel reverse transcriptase inhibitors with significant activity against HIV (Vince et al., 1988). An analog of CBV, abacavir, is currently in clinical trials (Faletto et al., 1997).. The present work continued the preclinical investigations of another CBV analog, 6AC, and the mechanism of its enhanced systemic delivery of CBV after oral dosing. ADA, the enzyme responsible for the conversion of 6AC to CBV, is localized in the presystemic organs, with the intestine having significantly greater activity than the liver (Ho et al., 1980; Chinsky et al., 1990). For 6AC, the intestine should be the primary organ where most of the first-pass effect takes place after an oral dose. Indeed, the disappearance half-lives of 6AC in the in vitro incubation studies were in accord with the relative tissue distribution of ADA. Homogenate incubations are often used as a means for in vitro prediction of in vivo metabolism. Obviously, ...
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride chemical properties, What are the chemical properties of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride 2508-72-7, What are the physical properties of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride ect.
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The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
2-(2,4-Dichlorophenoxy)aniline hydrochloride 89279-16-3 NMR spectrum, 2-(2,4-Dichlorophenoxy)aniline hydrochloride H-NMR spectral analysis, 2-(2,4-Dichlorophenoxy)aniline hydrochloride C-NMR spectral analysis ect.
Aniline Aniline Other names PhenylamineAminobenzeneBenzenamine Identifiers CAS number 62-53-3 SMILES NC1=CC=CC=C1 Properties Molecular formula C6H7N Molar mass
TY - JOUR. T1 - Catalytic antibodies. AU - Benkovic, Stephen. PY - 1992/1/1. Y1 - 1992/1/1. UR - http://www.scopus.com/inward/record.url?scp=0026717963&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026717963&partnerID=8YFLogxK. U2 - 10.1146/annurev.bi.61.070192.000333. DO - 10.1146/annurev.bi.61.070192.000333. M3 - Review article. C2 - 1497313. AN - SCOPUS:0026717963. VL - 61. SP - 29. EP - 54. JO - Annual Review of Biochemistry. JF - Annual Review of Biochemistry. SN - 0066-4154. ER - ...
N,N-Bis(2-chloro-1,1-dideuterioethyl)-3,4,4-trideuterio-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine | C7H15Cl2N2O2P | CID 44184217 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
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Chapter 1407 The Might of the Powerful The more dangerous the battlefield, the more the powerful could unleash their full strength!A giant,...
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Signs of the Side-chain Spin Couplings in Furans. II. 2-Methyl- and 3-Methylfuran, 2-Furfurylidenemalononitrile, and N-(2-Furfurylidene)aniline.. Rodmar, S ren; Fors n, Sture; Gestblom, Bo; Gronowitz, Salo; Hoffman, Ragnar A. ...
... cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards". Anticancer Drug Des. 14 (3): ... Before their use in chemotherapy, alkylating agents were better known for their use as sulfur mustard, ("mustard gas") and ... A common myth holds that Goodman and Gilman were prompted to study nitrogen mustards as a potential treatment for cancer ... Goodman, Gilman, and others began studying nitrogen mustards at Yale in 1942, and, following the sometimes dramatic but highly ...
Intermolecular ring formation of this aniline with nornitrogen mustard [334-22-5] yields 1-(2-isopropoxyphenyl)piperazine [ ...
... mustard gas MeSH D02.455.526.728.650 - nitrogen mustard compounds MeSH D02.455.526.728.650.050 - aniline mustard MeSH D02.455. ... propylbenzilylcholine mustard MeSH D02.455.526.728.650.760 - quinacrine mustard MeSH D02.455.526.728.650.913 - uracil mustard ... phosphoramide mustards MeSH D02.455.526.728.650.730.243 - cyclophosphamide MeSH D02.455.526.728.650.730.243.250 - ifosfamide ... propylbenzilylcholine mustard MeSH D02.092.877.883.333.780 - succinylcholine MeSH D02.092.877.883.333.800 - thiocholine MeSH ...
Anilines, Antineoplastic drugs, Carboxylate esters, Corticosteroids, Corticosteroid esters, Diketones, Nitrogen mustards, ...
Anilines, Organochlorides, Nitrogen mustards, Chloroethyl compounds, World Health Organization essential medicines, Wikipedia ... Nitrogen mustards arose from the derivatization of sulphur mustard gas after military personnel exposed to it during World War ... leading to the nitrogen mustards. With an acceptable therapeutic index in humans, nitrogen mustards were first introduced in ... aromatic mustards like chlorambucil were introduced as less toxic alkylating agents than the aliphatic nitrogen mustards, ...
It is also used to prepare sulfur mustard, commonly known as "mustard gas", by reaction with ethylene at 60 °C (the Levinstein ... 1/8 S8 Anilines (1) react with S2Cl2 in the presence of NaOH to give 1,2,3-benzodithiazolium salts (2) (Herz reaction) which ...
Chinese rapeseed oil was originally extracted from the field mustard. In the 19th century, rapeseed (B. rapa) was introduced by ... aniline (phenylamine). The substance was intended for industrial use but had been adulterated and illegally sold as olive oil, ... Turnip, rutabaga (swede), cabbage, Brussels sprouts, and mustard are related to rapeseed. Rapeseed belongs to the genus ... mustard oil is used in cooking. In the United Kingdom and Ireland, some chefs use a "cabbagey" rapeseed oil processed by cold- ...
... s are generally prepared by the reaction of a primary amine (e.g. aniline) and carbon disulfide in aqueous ... These natural isothiocyanates, such as allyl isothiocyanate, are also known as mustard oils. An artificial isothiocyanate, ... mustard, radish, Brussels sprouts, watercress, papaya seeds, nasturtiums, and capers. These species generate isothiocyanates in ...
... belongs to the class of nitrogen mustard alkylating agents. It works by interfering with the creation of DNA and RNA ... Catalytic hydrogenation produced the corresponding aniline. Heating in acid with oxirane, followed by treatment with phosphorus ... Nitrogen mustards, Specialty drugs, World Health Organization essential medicines, Wikipedia medicine articles ready to ...
His research on aniline helped lay the basis of the aniline-dye industry, and his research on coal tar laid the groundwork for ... He also examined its derivative, allyl isothiocyanate (mustard oil), in 1868, and studied various other isocyanates and ... Hofmann drew an analogy between aniline and ammonia. He wanted to convince chemists that organic bases could be described in ... In 1863, Hofmann showed that aniline blue is a triphenyl derivative of rosaniline and discovered that different alkyl groups ...
Methyl 4-isothiocyanatobutyrate, a new mustard oil present as a glucoside (glucoerypestrin) in Erysimum species". Acta Chemica ... used yellow dye but by the end of the 19th century had ceased to be in wide use due to the discovery of the synthetic aniline ... Glucobarbarin is a glucosinolate, the characteristic chemicals in the order Brassicales (Cabbages, mustards etc.) that Reseda ...
aniline Aniline dyes or basic dyes are a class of synthetic dyes derived from coal tar, first discovered in the 19th century. ... Top A B C D F G I K L M N O P Q R S T U W Y References quercitron Quercitron is a mustard yellow natural dye obtained from the ... mauveine Mauveine or aniline purple was the first synthetic organic chemical dye. mignonette Same as weld. mordant A mordant is ... Dried safflower blossoms can be used to produce yellow, mustard, khaki, olive green and red colors. Cotton tape dyed red with ...
Aldrin Allyl alcohol Allylamine Aluminum phosphide Aminopterin Amiton Amiton oxalate Ammonia Amphetamine Aniline Aniline, 2,4,6 ... Methylmercuric dicyanamide Methyltrichlorosilane Metolcarb Mevinphos Mexacarbate Mitomycin C Monocrotophos Muscimol Mustard gas ...
Thousands permanently damaged by eating industrial colza oil denatured with aniline and sold as olive oil. There was strong ... In New Delhi, India, edible mustard oil adulterated with Argemone mexicana seed oil caused epidemic dropsy in thousands of ...
Close rotation with crops susceptible to Sclerotinia sclerotiorum should be avoided (e.g. sunflower, canola, mustard plant and ... especially before cheaper aniline dyes became available. For the last fifty years or so,[citation needed] the plant has been ... this tolerance can also be explained by the higher water use efficiency compared to other oil crops such as linseed and mustard ...
... volatile Angelicin plus ultraviolet A radiation Aniline para-Anisidine Anthanthrene Anthracene Anthranilic acid Antimony ... N-Nitrosoproline Nitrotoluenes 5-Nitro-ortho-toluidine Nitrovin Nodularins Nylon 6 Oestradiol mustard Opisthorchis felineus ( ...
Always a medievalist at heart, Morris loathed the colors produced by the fashionable aniline dyes. He spent much of his time at ... dark mustard yellow) Chestnut hulls (peach to brown) Himalayan rhubarb root (bronze, yellow) Indigofera leaves (blue) Kamala ... The development of new, strongly colored aniline dyes followed quickly: a range of reddish-purples, blues, violets, greens and ... an aniline dye derived from coal tar. Alizarin, the red dye present in madder, was the first natural pigment to be duplicated ...
... based mainly on aniline and using petroleum or coal tar as the raw stock. Hunger, Klaus; Mischke, Peter; Rieper, Wolfgang; et ... mustard, jellies, and wine. Originally, these were dubbed 'coal-tar' colors because the starting materials were obtained from ...
Colman's, best known for its mustard, was founded by Jeremiah Colman in 1814. Isaac Reckitt founded Reckitt & Sons in 1840. ... "Baden Aniline and Soda Factory"), after its first two products Bauhaus - European chain of DIY stores founded by Heinz-Georg ...
Effect of glucuronic acid conjugate of aniline mustard on human ovarian and other tumours in vitro. Indian Journal of Cancer ... Effect of glucuronic acid conjugate of aniline mustard on human ovarian and other tumours in vitro.. ...
Tyg: Aniline latte. * I denna bild. Tyg: Aniline latte. * I denna bild. Tyg: Willow mustard ...
... small sofas in aniline leather and smooth pigmented leather hides. For the home and contract markets, ideal where space is at a ... Tuscany Crib 5 Style Mustard Genuine Leather 2 Seater Tub Sofa The Tuscany is a classically styled and timeless curved tub ...
Aniline Mustard Entry term(s). Mustard, Aniline N,N-Di(2-Chloroethyl)aniline N,N-bis(2-chloroethyl)aniline N,N-bis-(2- ... Mustard, Aniline. N,N-Di(2-Chloroethyl)aniline. N,N-bis(2-chloroethyl)aniline. N,N-bis-(2-chloroethyl)aniline. ... 1991; N,N-BIS-(2-CHOLOROETHYL)ANILINE was indexed under ANILINE MUSTARD 2005-2008, & under ANILINE COMPOUNDS (2005). ... Aniline Compounds (1970-1975). Nitrogen Mustard Compounds (1970-1975). Public MeSH Note:. ...
Black Full Aniline Leather. £ 785.40 In stock. 15% discount available if you sign up to our newsletter ... Coconut chair: Mustard Danish Wool. £ 561.00 Available to order, delivery in 6 - 8 weeks ...
N,N-bis(2-chloroethyl)aniline use Aniline Mustard N,N-bis-(2-chloroethyl)aniline use Aniline Mustard ...
N-Containing Compounds L-02 Hoffmann Mustard Oil Test & Reactions of aniline CL-84 for Neet Exam ...
Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual ... A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkins disease, and others. ...
Dimethyl Aniline (Xylidine). C. Dimethyl Ether (Methyl Ether). A. Dimethyl Formamide. B. ... Mustard Gas. *. Naphtha. B. Naphthalene. D. Naphthalenic Acid. B. Natural Gas. A. ...
... of p-hydroxy aniline mustard at CT-26/DNS cells in culture and accumulated in subcutaneous CT-26/DNS tumors after intravenous ...
Such irritants as strong soaps, mustard, acids, cantharides or Spanish fly, croton oil, aniline dyes, iodoform, some salves, ...
Equip wallet [Mustard] Genuine leather made in Japan Natural wood. $80.07 USD ... Money Clip Clip On Type 1 (One) Buono Aniline Blue. $59.48 USD ... Money Clip Clip On Type 1 (One) Buono Aniline White. $59.48 USD ...
Dimethyl Aniline (Xylidine). D. Dimethyl Ether (Methyl Ether). A. Dimethyl Formamide. B. ... Mustard Gas. A. Naphtha. D. Naphthalene. D. Naphthalenic Acid. D. Natural Gas. A. ...
Dimethyl Aniline (Xylidine). D. Dimethyl Ether (Methyl Ether). A. Dimethyl Formamide. B. ... Mustard Gas. A. Naphtha. D. Naphthalene. D. Naphthalenic Acid. D. Natural Gas. A. ...
These are the perfect addition to personalize your home.. Semi-aniline Leather_Dark Brown ... Plastic_Mustard 4 items * Plastic_Orange 1 item * Plastic_Pink 1 item ...
Distilled mustard (sulfur mustard; HD). Perchloromethyl mercaptan. Disulfoton*. Phenyl mercapatan. Epichlorohydrin*. ... Aniline*. Ethyl phosphorodichloridate. Propyleneimene*. Benzenethiol*. Ethylene dibromide. Sarin. bis-Chloromethyl ether*. ...
N,N-bis(2-chloroethyl)aniline use Aniline Mustard N,N-bis-(2-chloroethyl)aniline use Aniline Mustard ...
N,N-bis(2-chloroethyl)aniline use Aniline Mustard N,N-bis-(2-chloroethyl)aniline use Aniline Mustard ...
N,N-bis(2-chloroethyl)aniline use Aniline Mustard N,N-bis-(2-chloroethyl)aniline use Aniline Mustard ...
N,N-bis(2-chloroethyl)aniline use Aniline Mustard N,N-bis-(2-chloroethyl)aniline use Aniline Mustard ...
Full & Semi Aniline Lambskin. Semi Aniline Dakato Camel Leather. $50.00. Add to cart ...
The semi-aniline hide is dyed through with a lighter colour shade which then has an application of a darker specialised top ... An aniline finished leather, tanner to ensure a pleasing distressed finish from new. The final result is a subtle blend of ... This high quality aniline leather cleverly combines rugged vintage looks, with a gorgeously natural surface full of ... A natural grain semi-aniline finished hide which has been slightly buffed and milled, ensuring a luxurious soft and supple feel ...
Aniline. * Distressed and/or Pull-up. * Nubuck. * Pebble Grain. * Protected, Pigmented. * Semi-Aniline. ...
Monomethyl Aniline. * Monomethyl Ether (Methyl Ether). * Monovinyl Acetylene. * Mustard Gas. * N-Hexaldehyde ...
Pica Classic 544 ANILINE; Pica Classic 545 FOR ALL; Pica Classic 546 FOR ALL BLACK&WHITE; Pica Classic 547 Carpenter/Copying ... with a milder mustard sauce, and with the addition of carrot pieces. Piccalilli is known in Cyprus as πίκλα (pikla) - in Greek ...
Made from luxurious summer cowhide and soft aniline leather combinations or croc and snake emboss leather.. Lined and inside ... Aaron Passport Holder - Mustard Snake effect. $110.00. Aaron Passport Wallet - Chocolate Croc. $110.00 ...
All Stressless Leather is aniline-dyed. Color nuances are normal and should be expected. Please note that Leather absorbs ... Mustard Cori Leather. Passion Cori Leather. Petrol Cori Leather. Tan Cori Leather ...
Cottswald is a top-grain Nubuck leather sanded down to small raised leather fibers to create a unique velvety surface and appearance. This Italian native leather is tanned on fine European hides and exudes sophistication and elegance thats smooth to the touch.. Due to leathers natural characteristic, grain and color may vary.. ...
AGA Hob Lid Mat Pad Round Hob Cover With Straps Eco friendly Cotton Washable Reusable Mustard Beige Solid Drill Plane Cotton, 1 ... Manufacturers Description These fantastic boots are made of Italian leather with an aniline leather lining, so your unique ...
  • This high quality aniline leather cleverly combines rugged vintage looks, with a gorgeously natural surface full of characterful imperfections. (timelesschesterfields.com)
  • An aniline finished leather, tanner to ensure a pleasing distressed finish from new. (timelesschesterfields.com)
  • Made from luxurious summer cowhide and soft aniline leather combinations or croc and snake emboss leather. (convictbags.com)
  • All Stressless Leather is aniline-dyed. (vitality-web.com)
  • Free delivery on eligible orders of £20 or more, Manufacturer's Description These fantastic boots are made of Italian leather with an aniline leather lining, so your unique design will look great and make someone smile with the funny. (finex-group.ch)
  • Aniline leather is a natural material, color variations in batches and from batch to batch are standard. (conanti.com)
  • They are made from vegetable tanned aniline leather and suede, recycled polyester and recycled rubber. (thefeetingroom.com)
  • A natural grain semi-aniline finished hide which has been slightly buffed and milled, ensuring a luxurious soft and supple feel to match the elegant muted colour palette. (timelesschesterfields.com)
  • Brand: Wayz Color: Almond Milk, Light Grey and White Material: Vegetable tanned aniline. (thefeetingroom.com)
  • A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. (harvard.edu)
  • Barcelona style Chair with Ottoman in Authentic Full Aniline Leather NOT fake version by most middlemen,various colors available. (designreplica.com)
  • The Cushions are made of Full Aniline Leather in Super grade: Using Full Aniline Leather on both front and back. (designreplica.com)
  • Color can be various, but be noted, Aniline Leather is not a regular leather, we will buy the backing leather from Italy and process based on it. (designreplica.com)
  • Finishing Description Aniline: the leather finished in this way is characterized by the most natural look and quality. (buyleatheronline.com)
  • Aniline-finished lambskin nappa leather is a smooth and soft premium quality leather and represents the best of aniline-finished lamb and sheepskin leathers. (buyleatheronline.com)
  • Genuine South African, premium quality bovine aniline leather. (antelo.co.za)
  • Leather type: Top quality genuine aniline leather, sourced from the finest South African tanneries. (macarooncollection.co.za)
  • Antelo Josie Leather Shoulder Handbag / Sling - Mustard - Mustard is backordered and will ship as soon as it is back in stock. (macarooncollection.co.za)
  • This vegetable tanned leather is aniline dyed and hand polished to give a very attracted two-tone finish. (bookbindingaustralia.com.au)
  • Skilled workmanship, and high quality fastenings and bovine (cowhide) aniline leather ensure that it will remain a favourite for many years. (dubaruba.com)
  • Grease stains in full-aniline, saddle and vintage leather will pull away over time. (chill-line-care.nl)
  • Removable eco friendly insole, square toe and high quality semi aniline cow leather. (gramshoes.com)
  • However, with most things, a good Aniline leather will wear better. (thegracetales.com)
  • If you want a stain-resistant leather, its better to look for a semi-Aniline leather, this type loses the natural quality of Aniline but it is available in many more colours and is more resistant to spills. (thegracetales.com)
  • We understand that open grain aniline hides are not suitable for all, so we've scoured tanneries far and wide to bring you a leather that's suitably family friendly while still holding as much of a soft waxy feel as possible. (authenticfurniture.co.uk)
  • Using a special tanning process the punchbag range is able to provide all the attributes of a semi-aniline leather but with the durability of a pigmented hide. (authenticfurniture.co.uk)
  • A full grain aniline leather utilising the more 'characterful' hides results in a finish packed full of natural scars, marks and knicks. (authenticfurniture.co.uk)
  • A carefully selected raw leather from Slovenia is chosen for it's aniline finish, wax and cordovan-like look. (mspc-product.net)
  • Available in 5 velvet and 2 Aniline leather cover options, this is understandably one of our best sellers. (carltonfurniture.co.uk)
  • This two-tone, mixed media variation features an aniline leather wrapped framed, paired with seat cushions upholstered in one of our performance, stain-resistant fabrics by Maharam. (trnk-nyc.com)
  • Upholstered in Aniline Top Grain Italian Leather/leather match is used on the sides and back. (usafurniturewarehouse.com)
  • Aniline leather is a natural material, color variations in batches and from batch to batch are standard. (conanti.com)
  • Coveted by the shoe and handbag industry for its soft and open feel, this pure-aniline product is made from the center split of the hide. (dualoy.com)
  • Skin contact with nitrogen mustard vapors or liquid, will mustards have been shown to cause damage to the fetus in likely cause initial swelling and rash, followed by blistering. (cdc.gov)
  • There is some evidence that nitrogen mustard treatment in been exposed to nitrogen mustards. (cdc.gov)
  • The former moiety is a DNA damaging nitrogen mustard and the latter is a ligand for the ER. (nih.gov)
  • 3. Evaluation of naphthalmustine, a nitrogen mustard derivative of naphthalimide as a rationally-designed anticancer agent. (nih.gov)
  • 10. Novel DNA-directed alkylating agents consisting of naphthalimide, nitrogen mustard and lexitropsin moieties: synthesis, DNA sequence specificity and biological evaluation. (nih.gov)
  • Nitrogen mustard derivative of URACIL. (uchicago.edu)
  • The 3 seater sofa is a smaller sofa available in a wide selection of fabric types, ranging from opulent damasks and modern geometrics to bold colours and subdued plains, as well as aniline and top grain leathers. (myfurnituredirect.co.uk)
  • When released to air, nitrogen mustards will be broken down by compounds that are found in the air, but they may persist in air for a few days before being broken down. (cdc.gov)
  • 1. Synthesis and evaluation of substituted naphthalimide nitrogen mustards as rationally designed anticancer compounds. (nih.gov)
  • If you see colorization in the stain (for example: mustard = grease stain + colour transfer) then you want to remove the colour transfer as quickly as possible. (chill-line-care.nl)
  • In contrast, the larger mustard group of the dinitrobenzamide mustard compound SN 23862 forces the prodrug to bind at both active sites with only the 2-nitro group able to participate in hydride transfer from the FMN, explaining why only the 2-hydroxylamine reduction product is observed. (nih.gov)
  • 19. Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems. (nih.gov)
  • Nitrogen mustards (HN-1, HN-2, HN-3) are colorless to yellow, oily liquids that evaporate very slowly. (cdc.gov)
  • instead, they use a special aniline process to dye the premium grade Teju Lizard that the selected color permeates the skins thoroughly. (alligatormall.com)
  • Chromexcel is characterized by a rich pull-up in full aniline, hand rubbed finishes. (finwatchstraps.com)
  • Contact with high levels of nitrogen mustards can result in second- and third-degree burns. (cdc.gov)
  • Exposure to vapors of nitrogen mustards can damage the respiratory airways. (cdc.gov)
  • When nitrogen mustards are absorbed by the body, they may cause damage to bone marrow and the immune system. (cdc.gov)
  • Damage to cells lining your airways may begin susceptibility to nitrogen mustards. (cdc.gov)
  • Children exposed to nitrogen mustards would probably experience such effects as nasal and sinus pain or experience the same effects seen in exposed adults. (cdc.gov)
  • HIGHLIGHTS: It is unlikely that the general public will be exposed to nitrogen mustards agents HN-1, HN-2, and HN-3. (cdc.gov)