Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Quinolones: A group of derivatives of naphthyridine carboxylic acid, quinoline carboxylic acid, or NALIDIXIC ACID.4-Quinolones: QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.Copper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Curriculum: A course of study offered by an educational institution.Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Amides: Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed)Catalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Biology: One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.Databases, Chemical: Databases devoted to knowledge about specific chemicals.Small Molecule Libraries: Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.Drug Discovery: The process of finding chemicals for potential therapeutic use.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.High-Throughput Screening Assays: Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Nitracrine: Acridine antineoplastic agent used in mammary and ovarian tumors. It inhibits RNA synthesis.Porfiromycin: Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)Carbapenems: A group of beta-lactam antibiotics in which the sulfur atom in the thiazolidine ring of the penicillin molecule is replaced by a carbon atom. THIENAMYCINS are a subgroup of carbapenems which have a sulfur atom as the first constituent of the side chain.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Cell Line, Tumor: A cell line derived from cultured tumor cells.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Triazines: Heterocyclic rings containing three nitrogen atoms, commonly in 1,2,4 or 1,3,5 or 2,4,6 formats. Some are used as HERBICIDES.Drug Screening Assays, Antitumor: Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)K562 Cells: An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.DirectoryH(+)-K(+)-Exchanging ATPaseSoftware: Sequential operating programs and data which instruct the functioning of a digital computer.Vitamin K: A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.Disseminated Intravascular Coagulation: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Vitamin K 1: A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.Parents: Persons functioning as natural, adoptive, or substitute parents. The heading includes the concept of parenthood as well as preparation for becoming a parent.Condiments: Aromatic substances added to food before or after cooking to enhance its flavor. These are usually of vegetable origin.Qi: The vital life force in the body, supposedly able to be regulated by acupuncture. It corresponds roughly to the Greek pneuma, the Latin spiritus, and the ancient Indian prana. The concept of life-breath or vital energy was formulated as an indication of the awareness of man, originally directed externally toward nature or society but later turned inward to the self or life within. (From Comparison between Concepts of Life-Breath in East and West, 15th International Symposium on the Comparative History of Medicine - East and West, August 26-September 3, 1990, Shizuoka, Japan, pp. ix-x)Therapeutic Touch: Placing of the hands of the healer upon the person to be cured with the intent of spiritual energetic healing.Mustard Plant: Any of several BRASSICA species that are commonly called mustard. Brassica alba is white mustard, B. juncea is brown or Chinese mustard, and B. nigra is black, brown, or red mustard. The plant is grown both for mustard seed from which oil is extracted or used as SPICES, and for its greens used as VEGETABLES or ANIMAL FEED. There is no relationship to MUSTARD COMPOUNDS.PrintingPlant Growth Regulators: Any of the hormones produced naturally in plants and active in controlling growth and other functions. There are three primary classes: auxins, cytokinins, and gibberellins.Peer Review: An organized procedure carried out by a select committee of professionals in evaluating the performance of other professionals in meeting the standards of their specialty. Review by peers is used by editors in the evaluation of articles and other papers submitted for publication. Peer review is used also in the evaluation of grant applications. It is applied also in evaluating the quality of health care provided to patients.Indoleacetic Acids: Acetic acid derivatives of the heterocyclic compound indole. (Merck Index, 11th ed)Mustard Gas: Severe irritant and vesicant of skin, eyes, and lungs. It may cause blindness and lethal lung edema and was formerly used as a war gas. The substance has been proposed as a cytostatic and for treatment of psoriasis. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP-85-002, 1985) (Merck, 11th ed).Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.
Bystander killing of tumour cells by antibody-targeted enzymatic activation of a glucuronide prodrug. (1/14)RHI-betaG-PEG, formed by linking poly(ethylene glycol)-modified beta-glucuronidase to Mab RH1, was employed to examine bystander killing of antigen-negative N1S1 rat hepatoma cells by activation of a glucuronide prodrug (BHAMG) of p-hydroxyaniline mustard (pHAM) at antigen-positive AS-30D rat hepatoma cells. Sequential treatment of cells with 10 microg ml(-1) RH1-betaG-PEG and 20 microM BHAMG was not toxic to N1S1 cells but killed 99% of AS-30D cells. Over 98% of N1S1 cells, however, were killed in mixed populations containing as few as 2% AS-30D cells after identical treatment, demonstrating an in vitro bystander effect. Subcutaneous injection of AS-30D and N1S1 cells in BALB/c nu/nu mice produced solid tumours containing both cells. Uptake of radiolabelled RH1-betaG-PEG in solid AS-30D and mixed AS-30D/N1S1 tumours was 11.6 and 9.3 times greater than a control antibody conjugate 120 h after i.v. injection. Intravenous treatment with RH1-betaG-PEG and BHAMG cured seven of seven nude mice bearing solid s.c. AS-30D tumours and significantly delayed, compared with control conjugate and prodrug treatment, the growth of mixed N1S1/AS-30D tumours with one cure, showing that targeted activation of BHAMG kills bystander tumour cells in vivo. (+info)
A rationally designed genotoxin that selectively destroys estrogen receptor-positive breast cancer cells. (2/14)We describe a novel strategy to increase the selective toxicity of genotoxic compounds. The strategy involves the synthesis of bifunctional molecules capable of forming DNA adducts that have high affinity for specific proteins in target cells. It is proposed that the association of such proteins with damaged sites in DNA can compromise protein function and/or DNA repair resulting in increased toxicity. We describe the synthesis of a bifunctional compound consisting of an aniline mustard linked to the 7alpha position of estradiol. This novel compound can form covalent DNA adducts that have high affinity for the estrogen receptor. Breast cancer cells that express high levels of the estrogen receptor showed increased sensitivity to the cytotoxic effects of the new compound. (+info)
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures. (3/14)The efficacy of cancer gene therapy depends critically on "bystander effects" by which genetic modification of tumor cells results in killing of unmodified cells in the local microenvironment. In gene-dependent enzyme-prodrug therapy, expression of a prodrug-activating suicide gene is used to generate a cytotoxic metabolite that diffuses to nontransduced cells. The objective of this study was to develop a physiologically relevant tissue culture model for quantifying bystander effects and to validate the model using as an example the activation of dinitrobenzamide prodrugs (e.g., CB 1954) by Escherichia coli aerobic nitroreductase (NTR). Bystander effects were measured in three-dimensional multilayer cocultures of NTR+ and NTR- cells by determining clonogenic survival curves for both cell types using V79, Skov3, or WiDr as parental cell lines. Bystander killing by CB 1954 was much more efficient in multilayers than monolayers at equivalent cell:medium ratios, whereas the chloromustard analogue of CB 1954 showed even greater efficiency. For a series of dinitrobenzamides, bystander killing in multilayers showed a positive correlation with prodrug lipophilicity and also correlated with the bystander effect in mixed tumor xenografts grown from the same NTR+ and NTR- WiDr cell lines (r(2) = 0.84; P < 0.001). The multilayer model identified a bromomustard prodrug (SN 24927) with superior therapeutic activity to CB 1954 that provided curative activity against WiDr tumors comprising 1:1 mixtures of NTR+ and NTR- cells. This study demonstrates the utility of the multilayer tissue culture model for quantifying and optimizing bystander effects in tumors and identifies a new lead prodrug for NTR gene-dependent enzyme-prodrug therapy. (+info)
2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT. (4/14)An important feature of gene-directed enzyme-prodrug therapy is that prodrug activation can provide diffusible cytotoxic metabolites capable of generating a local bystander effect in tumours. Activation of the aziridinyl dinitrobenzamide CB 1954 by E. coli nitroreductase (NTR) provides a bystander effect assumed to be due to the potently cytotoxic 4-hydroxylamine metabolite. We show that there are four cytotoxic extracellular metabolites of CB 1954 in cultures of NTR-expressing tumour cells (the 2- and 4-hydroxylamines and their corresponding amines). The 4-hydroxylamine is the most cytotoxic in DNA crosslink repair defective cells, but the 2-amino derivative (CB 10-236) is of similar potency to the 4-hydroxylamine in human tumour cell lines. Importantly, CB 10-236 has much superior diffusion properties to the 4-hydroxylamine in multicellular layers grown from the SiHa human cervical carcinoma cell line. These results suggest that the 2-amine, not the 4-hydroxylamine, is the major bystander metabolite when CB 1954 is activated by NTR in tumours. The corresponding dinitrobenzamide nitrogen mustard SN 23862 is reduced by NTR to form a single extracellular metabolite (also the 2-amine), which has superior cytotoxic potency and diffusion properties to the CB 1954 metabolites. These results are consistent with the reported high bystander efficiency of SN 23862 as an NTR prodrug in multicellular layers and tumour xenografts. (+info)
Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents. (5/14)A series of bifunctional compounds was prepared consisting of 17beta estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our studies was to determine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to the estrogen receptor. Linker characteristics were pivotal determinants underlying the ability of the compounds to kill selectively breast cancer cells that express the estrogen receptor. (+info)
Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy. (6/14)Cancer chemotherapy may be improved by increasing antineoplastic drug specificity for tumor cells. We have synthesized a glucuronide prodrug that can be enzymatically converted to an antineoplastic agent at tumor cells that are able to bind beta-glucuronidase-monoclonal antibody conjugates. The glucuronide prodrug BHAMG, the tetra-n-butyl ammonium salt of (p-di-2-chloroethylaminophenyl-beta-D-glucopyranoside) uronic acid, was 150 times less toxic than the parent drug, N,N-di-(2-chloroethyl)-4-hydroxyaniline, to HepG2 human hepatoma cells and over 1000-fold less toxic than the parent drug to AS-30D rat hepatoma cells in vitro. In the presence of beta-glucuronidase, BHAMG was activated and became as toxic as the parent drug N,N-di-(2-chloroethyl)4-hydroxyaniline. A conjugate (RH1-beta G) was formed by linking beta-glucuronidase to a monoclonal antibody which binds to an antigen expressed on the surface of AS-30D cells. The concentration of BHAMG causing 50% inhibition of AS-30D cellular protein synthesis was reduced over 1000-fold, from greater than 770 microM to less than 0.74 microM after these cells were preincubated with RH1-beta G. Specificity of BHAMG activation at antigen-positive cells was shown by monoclonal antibody RH1 blocking of RH1-beta G conversion of BHAMG to toxic drug and by the inability of BHAMG to be converted to active drug when antigen-negative control cells were preincubated with RH1-beta G. Our results show that the targeted-beta-glucuronidase activation of BHAMG can increase the specificity of chemotherapy for rat hepatoma in vitro and suggest that the targeted activation of glucuronide prodrugs may be useful for cancer therapy. (+info)
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug. (7/14)PURPOSE: Antibody-directed enzyme prodrug therapy is a two-stage treatment whereby a tumor-targeted antibody-enzyme complex localizes in tumor for selective conversion of prodrug. The purpose of this study was to establish optimal variables for single administration of MFECP1, a recombinant antibody-enzyme fusion protein of an anti-carcinoembryonic antigen single-chain Fv antibody and the bacterial enzyme carboxypeptidase G2 followed by a bis-iodo phenol mustard prodrug. MFECP1 is manufactured in mannosylated form to facilitate normal tissue elimination. EXPERIMENTAL DESIGN: Pharmacokinetic, biodistribution, and tumor localization studies were used to test the hypothesis that MFECP1 localizes in tumor and clears from normal tissue via the liver. Firstly, safety of MFECP1 and a blood concentration of MFECP1 that would avoid systemic prodrug activation were tested. Secondly, dose escalation of prodrug was done. Thirdly, the dose of MFECP1 and timing of prodrug administration were optimized. RESULTS: MFECP1 was safe and well tolerated, cleared rapidly via the liver, and was less immunogenic than previously used products. Eighty-fold dose escalation from the starting dose of prodrug was carried out before dose-limiting toxicity occurred. Confirmation of the presence of enzyme in tumor and DNA interstrand cross-links indicating prodrug activation were obtained for the optimal dose and time point. A total of 28 of 31 patients was evaluable for response, the best response being a 10% reduction of tumor diameter, and 11 of 28 patients had stable disease. CONCLUSIONS: Optimal conditions for effective therapy were established. A study testing repeat treatment is currently being undertaken. (+info)
Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target. (8/14)(+info)
Alkylating antineoplastic agent
... cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards". Anticancer Drug Des. 14 (3): ... Before their use in chemotherapy, alkylating agents were better known for their use as sulfur mustard, ("mustard gas") and ... A common myth holds that Goodman and Gilman were prompted to study nitrogen mustards as a potential treatment for cancer ... Goodman, Gilman, and others began studying nitrogen mustards at Yale in 1942, and, following the sometimes dramatic but highly ...
List of MeSH codes (D02)
... mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455.526.728.650.050 --- aniline mustard MeSH ... quinacrine mustard MeSH D02.455.526.728.650.913 --- uracil mustard MeSH D02.455.526.913 --- trihalomethanes MeSH D02.455. ... phosphoramide mustards MeSH D02.455.526.728.650.730.243 --- cyclophosphamide MeSH D02.455.526.728.650.730.243.250 --- ... propylbenzilylcholine mustard MeSH D02.092.877.883.333.780 --- succinylcholine MeSH D02.092.877.883.333.800 --- thiocholine ...
The general method for the formation of isothiocyanates proceeds through the reaction between a primary amine (e.g. aniline) ... These natural isothiocyanates, such as allyl isothiocyanate, are also known as mustard oils. An artificial isothiocyanate, ... Vegetable foods with characteristic flavors due to isothiocyanates include wasabi, horseradish, mustard, radish, Brussels ...
It is also used to prepare the sulfur mustard "gas" by reaction with ethylene at 60 °C (the Levinstein process): S2Cl2 + 2 C2H4 ... 1/8 S8 Anilines react with S2Cl2 in the presence of NaOH via the so-called Herz reaction to give ortho-aminothiophenolates. ...
August Wilhelm von Hofmann
His research on aniline helped lay the basis of the aniline-dye industry. His earliest research on coal tar laid the groundwork ... He also examined its derivative, allyl isothiocyanate (mustard oil), in 1868, and studied various other isocyanates and ... Hofmann drew an analogy between aniline and ammonia. He wanted to convince chemists that organic bases could be described in ... In 1863, Hofmann showed that aniline blue is a triphenyl derivative of rosaniline and discovered that different alkyl groups ...
Otherwise known as L-phenylalanine mustard, or L-PAM, melphalan is a phenylalanine derivative of mechlorethamine. Melphalan ... Catalytic hydrogenation produced the corresponding aniline. Heating in acid with oxirane, followed by treatment with phosphorus ... is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents. An alkylating agent adds an alkyl group ( ...
List of food contamination incidents
Thousands permanently damaged by eating industrial colza oil denatured with aniline and sold as olive oil. There was strong ... 1998 - In New Delhi, India, edible mustard oil adulterated with Argemone mexicana seed oil caused epidemic dropsy in thousands ...
First reliable synthesis of pure sulfur mustard (1886, also see Meyer's account on sulfur mustard) Coining of the concepts of ... the molar mass of diethyl ether was determined experimentally at 72 g/mol and that for aniline 93 g/mol. Chisholm 1911, p. 349 ...
Glossary of dyeing terms
aniline Aniline dyes or basic dyes are a class of synthetic dyes derived from coal tar, first discovered in the 19th century. ... Dried safflower blossoms can be used to produce yellow, mustard, khaki, olive green and red colors. Cotton tape dyed red with ... mauveine Mauveine or aniline purple was the first synthetic organic chemical dye. mignonette Same as weld. mordant A mordant is ... Because of poor colorfastness, aniline dyes are seldom used with textiles today. archil Archil is a dye produced from the ...
List of extremely hazardous substances
Aldrin Allyl alcohol Allylamine Aluminum phosphide Aminopterin Amiton Amiton oxalate Ammonia Amphetamine Aniline Aniline, 2,4,6 ... 3-chloropropyl octyl Sulfur dioxide Sulfur mustard Sulfur tetrafluoride Sulfur trioxide Sulfuric acid Tabun Tellurium Tellurium ... Methylmercuric dicyanamide Methyltrichlorosilane Metolcarb Mevinphos Mexacarbate Mitomycin C Monocrotophos Muscimol Mustard gas ...
List of IARC Group 3 carcinogens
... volatile Angelicin plus ultraviolet A radiation Aniline para-Anisidine Anthanthrene Anthracene Anthranilic acid Antimony ... N-Nitrosoproline Nitrotoluenes 5-Nitro-ortho-toluidine Nitrovin Nodularins Nylon 6 Oestradiol mustard Opisthorchis felineus ( ...
Always a medievalist at heart, Morris loathed the colors produced by the fashionable aniline dyes. He spent much of his time at ... dark mustard yellow) Himalayan rhubarb root (yellow) Indigofera plant (blue) Kamala tree (red) Larkspur plant (yellow) Madder ... The development of new, strongly colored aniline dyes followed quickly: a range of reddish-purples, blues, violets, greens and ... an aniline dye derived from coal tar. Alizarin, the red dye present in madder, was the first natural pigment to be duplicated ...
... based mainly on aniline and using petroleum or coal tar as the raw stock. Klaus Hunger, Peter Mischke, Wolfgang Rieper, ... mustard, jellies, and wine. Originally, these were dubbed 'coal-tar' colors because the starting materials were obtained from ...
The 11[beta] molecule comprises a ligand for the androgen receptor (AR), which is crucial to progression and survival of many prostate cancers, tethered to a DNA-damaging aniline mustard. The compound was designed to exhibit ...
Immunomedics Reports First Experimental Studies Combining Antibody-Drug Conjugate With Antibody-Directed Radiation Therapy for...
SAN FRANCISCO, Jan. 24, 2011 (GLOBE NEWSWIRE) -- Immunomedics, Inc. (Nasdaq:IMMU), a biopharmaceutical company primarily focused on the development of monoclonal antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases, today announced that combining antibody-directed drug and radionuclide therapeutics for pancreatic cancer improved efficacy in preclinical studies with minimal toxicity. Results from these investigations were presented at the 2011 Gastrointestinal Cancers Symposium.
Title: Glucuronides in Anti-Cancer Therapy. VOLUME: 3 ISSUE: 2. Author(s):Xi Chen, Bingyuan Wu and Peng George Wang. Affiliation:Department of Chemistry, Wayne State University, Detroit, MI 48202, USA. Keywords:glucuronides, anti cancer therapy, glucuronide prodrug, prodrug monotherapy, antibody directed enzyme prodrug therapy, combined chemo radiotherapy. Abstract: Glucuronide prodrugs have shown promising efficacy in anti-cancer therapy due to their increased specificity and reduced systemic toxicity. The prodrugs can be used in prodrug monotherapy (PMT), which is based on elevated tumor β-glucuronidase activity. β-Glucuronidase activates the low-toxic prodrugs into highly cytotoxic agents specifically in the tumor site. The specificity of the prodrugs can be further improved by combined use with monoclonal antibodies against tumor-specific antigens, namely antibody-directed enzyme prodrug therapy (ADEPT), and the potency of the prodrugs can be greatly enhanced with the incorporation of an ...
In this report, we detail Substrate Mediated Enzyme Prodrug Therapy (SMEPT) as a novel approach in drug delivery which relies on enzyme-functionalized cell culture substrates to achieve a localized conversion of benign prodrug(s) into active therapeutics with subsequent delivery to adhering cells or adjacent tissues. For proof-of-concept SMEPT, we use surface adhered micro-structured physical hydrogels based on poly(vinyl alcohol), β-glucuronidase enzyme and glucuronide prodrugs. We demonstrate enzymatic activity mediated by the assembled hydrogel samples and illustrate arms of control over rate of release of model fluorescent cargo. SMEPT was not impaired by adhering cells and afforded facile time - and dose - dependent uptake of the in situ generated fluorescent cargo by hepatic cells, HepG2. With the use of a glucuronide derivative of an anticancer drug, SN-38, SMEPT afforded a decrease in cell viability to a level similar to that achieved using parent drug. Finally, dose response was achieved using
Unscramble aniline | Words unscrambled from letters aniline | Scrabble Word aniline | Words Made with the Letters aniline
Unscramble aniline, Unscramble letters aniline, Point value for aniline, Word Decoder for aniline, Word generator using the letters aniline, Word Solver aniline, Possible Scrabble words with aniline, Anagram of aniline
Gentaur molecular products has all kinds of products like :search , Nacala \ Aniline \ 02915-25 for more molecular products just contact us
Antibody-directed enzyme prodrug therapy legal definition of antibody-directed enzyme prodrug therapy
Definition of antibody-directed enzyme prodrug therapy in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is antibody-directed enzyme prodrug therapy? Meaning of antibody-directed enzyme prodrug therapy as a legal term. What does antibody-directed enzyme prodrug therapy mean in law?
Visit ChemicalBook To find more Aniline(62-53-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Aniline(62-53-3). At last,Aniline(62-53-3) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
Latest China HS Code & tariff for n dimethyl aniline - Tariff & duty, regulations & restrictions, landed cost calculator, customs data for n dimethyl aniline in ETCN. China customs statistics trade data.
Modern Tribalist: Mice genetically engineered to lack a single enzyme in their brains are more adept at learning than their...
The engineered mice were more adept at learning to navigate a water maze and remembering that being in a certain box involves a mild shock. Equally important, Dr. Bibb said, when a situtation changed, such as the water maze being rearranged, the engineered mice were much faster to realize that things were different and work out the new route ...
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.. ...
4-(Methylmercapto)aniline 104-96-1 Precursor and Downstream products, 4-(Methylmercapto)aniline Precursor products, 4-(Methylmercapto)aniline Downstream products ect.
A lot of planning has to go into making sure a Sweet Lisa cake can be delivered without damage. "In the back of your mind, you know youve got to get this cake to where its got to be. ... We always say the only two people qualified to deliver are the person who made it and the person who ordered it. Delivery can be hard because in some cases you have to do a lot of construction on site," Maronian says.. ...
The international steroid trade is run by sophisticated global syndicates adept at keeping their identities secret and highly adept at reaching their target markets
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Hello Ive been training BJJ about nine months and one of the chokes that for whatever reason I have become somewhat adept at is the Ezekiel from someones guard and the mount and roll technique. I have a question concerning the nature of this choke, It was taught to the class a couple weeks into my training however i rarely see anyone use it even though it seems like its wide open in many occasions. I have used it many times and have had more success with this submission than any others
Saat waktu telah berlalu, berjalan perlahan meninggalkan keadaan pahit kala itu. Saat itulah aku mulai sadar bahwa aku kehilangan dirimu. Lalu mengapa saat-saat itu harus kembali hadir. Mengapa saat-saat itu harus kembali disini, di pikiranku, di nadiku. Aku menghembuskan napas dengan berat. Ini seperti Déjà vu. Kenangan manis dan pahit bersamamu harus kembali terputar. Ini…
The ADEPT Modular Head and Cup is a precision bearing. The diameter, surface finish, sphericity and radial clearance are controlled using proprietry techniques developed specifically for Metal on Metal hip arthroplasty.. ADEPT Hip Stem: The design concept of the ADEPT cementless stem (6Al-7Nb) compliments the exceptional performance of the ADEPT Metal on Metal Modular Head and Cup.. ADEPT Resurfacing: Setting the standards in Metal on Metal manufacturing technology. Finsbury accept no compromise in achieving the highest specification for accuracy and quality.. ...
Vapor-Liquid Equilibria in the System of Toluene/Aniline, Aniline/Naphthalene, and Naphthalene/Quinoline<...
TY - JOUR. T1 - Vapor-Liquid Equilibria in the System of Toluene/Aniline, Aniline/Naphthalene, and Naphthalene/Quinoline. AU - Lee, Chang-Ha. AU - Chen, Quen. AU - Mohamed, Rahoma S.. AU - Holder, Gerald D.. PY - 1992/4/1. Y1 - 1992/4/1. N2 - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately correlated with the modified Peng-Roblnson equation of state by using density-dependent mixing rules. The binary interaction parameters and correction factors for the equation of state are reported at each isotherm. The presence of coal-derived solids in these binary systems did not influence any of the binary bubble pressures.. AB - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately ...
N-Methyl Aniline 100-61-8, China N-Methyl Aniline 100-61-8 Manufacturers, China N-Methyl Aniline 100-61-8 Suppliers - Yangshi...
We,China N-Methyl Aniline 100-61-8 Suppliers and China N-Methyl Aniline 100-61-8 Manufacturers, provide N-Methyl Aniline 100-61-8 product and the products related with China N-Methyl Aniline 100-61-8 - Yangshi Chemica
In part 22 of 23 of this classic series Elbert Benjamine explains the astrological significance of the Sun and its relationship to the tarot card, The Adept.
You are viewing an interactive 3D depiction of the molecule n,n-bis(2-chloroethyl)-1,4-benzenediamine (C10H14Cl2N2) from the PQR.
Heres the rest of them; first part here. Please leave comments back over on the first part.- Hellfire Citadel: Blood Furnace Shadowmoon Adepts on Heroic now do...
Antibodies | Free Full-Text | Diving through Membranes: Molecular Cunning to Enforce the Endosomal Escape of Antibody-Targeted...
Membranes are vital barriers by which cells control the flux of molecules and energy between their exterior and interior and also between their various intracellular compartments. While numerous transport systems exist for ions and small molecules, the cytosolic uptake of larger biological molecules and in particular antibody-targeted drugs, is a big challenge. Inducing leakage of the plasma membrane is unfavorable since the target cell specificity mediated by the antibody would likely be lost in this case. After binding and internalization, the antibody drug conjugates reach the endosomes. Thus, enforcing the endosomal escape of anti-tumor toxins without affecting the integrity of other cellular membranes is of paramount importance. Different strategies have been developed in the last decades to overcome endosomal accumulation and subsequent lysosomal degradation of targeted protein-based drugs. In this review we summarize the various efforts made to establish efficient techniques to disrupt the
TY - JOUR. T1 - Intermediates in the reaction of aniline with formaldehyde catalyzed by acids. AU - Bochkarev, V. V.. AU - Soroka, L. S.. PY - 2000/5/1. Y1 - 2000/5/1. N2 - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the semiempirical MNDO method. According to the calculation results, protonated N-(hydroxymethyl)aniline and ortho-, meta-, and paraσ-complexes are formed through the ion-dipole complex. Further transformations of these intermediates, which determine the structure of the final products, depend on the possibility of proton abstraction from the σ-complexes with formation of a quinonimine structure, as well as on the lability of the hydroxymethyl group in the protonated amino alcohol.. AB - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the ...
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride 2508-72-7 Chemical Properties Physical Properties
N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride chemical properties, What are the chemical properties of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride 2508-72-7, What are the physical properties of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride ect.
Matter is composed of atoms or groups of atoms called molecules. The arrangement of particles in a material depends on the physical state of the substance. In a solid, particles form a compact structure that resists flow. Particles in a liquid have more energy than those in a solid. They can flow past one another, but they remain close. Particles in a gas have the most energy. They move rapidly and are separated from one another by relatively large distances. ...
Connect with Dr. William Sirover, Nephrology and Dialysis, Cherry Hill, NJ. Video chat, send a message, ask a text question, or make a virtual appointment on the doctors Virtual Practice on HealthTap.
Antibody-targeted cell fusion. Bringing amyloid into focus. Modifying murine von Willebrand factor A1 domain for in vivo...
Antibody-targeted cell fusion. Bringing amyloid into focus. Modifying murine von Willebrand factor A1 domain for in vivo assessment of human platelet therapies
Search Indian Aniline Oil Manufacturers and Suppliers Details - Contact to Aniline Oil Exporters in India, Aniline Oil Wholesalers, Aniline Oil Distributors and Traders from India.
Best stories, art and poetry about bystander effect. Authors who write about bystander effect. Other Red Fez members intersted in bystander effect.
CCCC 2006, Volume 71, Issue 10, Abstracts pp. 1407-1426 | Collection of Czechoslovak Chemical Communications
The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
Aniline Market (Application - Methylene Diphenyl Diisocyanate (MDI) and Rubber Processing Chemicals and Dyes and Pigments; End...
Global Aniline Market was valued at US$ 9.75 Bn in 2013 and is likely to reach US$ 15.66 Bn by 2020, expanding at a CAGR of 7.0% during the forecast period between 2014 and 2020. In terms of volume, global demand for aniline stood at 5,470 kilo tons in 2013
... Other names PhenylamineAminobenzeneBenzenamine Identifiers CAS number 62-53-3 SMILES NC1=CC=CC=C1 Properties Molecular formula C6H7N Molar mass
Plot No #30 & 31, Survey No: 196, 197, 198 First Floor, Rajiv Gandhi Nagar, Moosapet(V), GHMC Kukatpally circle, Balanagar(M), RR Dist, Telangana. [email protected] ...
Working with networks and Novell software since 1994. Novell adept for life after being brainwashed during an internship at the Novell European Support Center in Duesseldorff. CNE since 1996 and CLP since 2006.. ...
Unless youre adept at living a stress-free life (do share!), here are some ways to stay in good health while succeeding in business.
Kubuntu has released Kubuntu 5.10, including the newly released KDE 3.4.3. Significant additions in this release include Adept package manager and Guidance configuration tools. The Kubuntu 5.10 Live CD also includes the best KDE on Windows software: Kexi and KDE PIM. Download now and test out the newest KDE.
Kubuntu has released Kubuntu 5.10, including the newly released KDE 3.4.3. Significant additions in this release include Adept package manager and Guidance configuration tools. The Kubuntu 5.10 Live CD also includes the best KDE on Windows software: Kexi and KDE PIM. Download now and test out the newest KDE.
ASTM D611 - 12(2016) Standard Test Methods for Aniline Point and Mixed Aniline Point of Petroleum Products and Hydrocarbon...
D611 - 12(2016) Standard Test Methods for Aniline Point and Mixed Aniline Point of Petroleum Products and Hydrocarbon Solvents , aniline point, aromatics, mixed aniline point,,
Synonyms for mustard in Free Thesaurus. Antonyms for mustard. 4 synonyms for mustard: table mustard, mustard greens, Indian mustard, leaf mustard. What are synonyms for mustard?
Register to win an Audience aR2p Adept Response Power Conditioner (MSRP $695) we are giving away. According to Audience: The Audience Adept Response aR2p power conditioner is designed to elevate the performance of your audio system and provide superior power protection. Its ideal for single-component applications like monoblock amplifiers, receivers, video projectors and video displays and plugs directly into a power outlet with no separate power cord required. The aR2p is hand-built with premium-quality high-current components throughout.
Learn how to grow Mustard Greens with our simple step by step guide. Mustard greens, also known as Indian mustard, Chinese mustard and leaf mustard, is a species of mustard plant.
Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane. Like most volatile amines, it possesses the somewhat unpleasant odour of rotten fish. It ignites readily, burning with a smoky flame characteristic of aromatic compounds. Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models | Springer for Research &...
Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide that is particularly refractory to chemotherapy. Several studies have proposed combination chemotherapy regimen...
Choline sensing based on in situ polymerization of aniline on the surface of upconverting nanoparticles - Journal of Materials...
A novel choline detection strategy is developed based on in situ polymerization of aniline on the surface of upconverting nanoparticles (UCNPs). In acidic buffer solution, aniline was protonated and attached to the surface of negatively charged UCNPs via electrostatic interactions. The in situ polymerization
... ,Analysis of large numbers of samples may be carried out using this system, which requires minimum operator attention. System control and data processing is provided by PowerStream software and interface CE 4900. The elegant, powerful and very easy to use software ope,biological,biology supply,biology supplies,biology product
ChemIDplus - 100482-72-2 - JLROSPQNNNKWQD-UHFFFAOYSA-N - tert-Butylamine, N,N-bis(2-chloroethyl)-, N-oxide, picrate - Similar...
100482-72-2 - JLROSPQNNNKWQD-UHFFFAOYSA-N - tert-Butylamine, N,N-bis(2-chloroethyl)-, N-oxide, picrate - Similar structures search, synonyms, formulas, resource links, and other chemical information.
The bystander effect is defined as the induction of cellular damage in unirradiated cells, induced by irradiated cells in the surrounding area. Our laboratory has previously identified that an environmentally relevant dose of UVA is able to induce th
Removal of aniline from aqueous solutions by activated carbon coated by chitosan on Environmental XPRT
Article Removal of aniline from aqueous solutions by activated carbon coated by chitosan. In this work, activated carbon (AC) coated by chitosan was synthesized and characterized by Fourier transform infrared spectrophotometer and scanning electron m...
4-(8-Methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline | C17H17N3O2 | ChemSpider
Structure, properties, spectra, suppliers and links for: 4-(8-Methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline.
Provide fine chemicals, building blocks and pharmaceutical intermediates. PI-42623 N,N-Bis[3-(Fmoc-amino)propyl]glycine potassium sulfate (346694-76-6) Synonym: Molecular Formula: C38H40KN3O10S Weight: 769.9 CAS No: 346694-76-6 Appearance: Purity: FM Point: Order online from laboratory chemical supplier and distributor.
The solvate structure of 3,4-dichloro-1-nitro-benzene with aniline, 2C6H3Cl2NO2·C6H7N, is reported. Ribbons of 3,4-dichloro-nitro-benzene, formed by ClCl and N - OCl inter-actions, are linked together via N - HO hydrogen bonds with aniline into an undulating two-dimensional sheet.. ...
I have become somehow intimate with the exigencies of the natural functioning of both the stomach and the mind, and have become relatively adept at procuring both food and stimuli that will make me at once feel reasonably healthy and adequately engaged and productive, rendering these biological systems generally predictable, predominantly stable, verging on the habitual. Unfortunately, permeating every stage of the metabolism of both my mind and body, there is an unstable element, a tenacious and inscrutable presence which destabilises the placid equanimity that would be so pleasantly balanced without it. I hadnt thought about it much recently, preferring to stare into the wine-glass rather than into its entirely specular face, but a brief conversation on the terrace at the AA, and my attempt to be truthful rather than phatic, led me to think a little about its impact on my production, and by association my life. Asked how (or why, I cannot remember which) I was so continuously creative, I ...
Ive grown adept at avoiding it, calling it to the carpet if unavoidable. I slip at every now and then, even slinging a bit of if myself when Im in the mood ...
The adolescent, a survivor of Eastern Equine Encephalitis, was paired with an adult mentor, a survivor of a TBI. High quality surgical gloves with no detectable protein have no detectable Hev b 5. Although wild-type Pseudomonas aeruginosa expresses the triclosan target enoyl-acyl carrier protein reductase, it is triclosan resistant due to expression of the MexAB-OprM efflux system. Effect of pH and human serum albumin on the cytotoxicity of a buy cialis online glucuronide prodrug of 9-aminocamptothecin. Typical manifestations of hyperaldosteronism include salt retention, hypokalemia, and metabolic alkalosis. A histochemical study of enzymes of carbohydrate metabolism in the rat metanephros.. New understanding of the concepts of circularity, hypothesizing, and neutrality are now possible, given the systemic epistemology on which the early Milan model was based. Interactions of labeled MPs with endothelial cells could be triggered and generic cialis from india modulated by magnetic guidance. ...
Lisdexamfetamine prodrug activation by peptidase-mediated hydrolysis in the cytosol of red blood cells Johannah Sharman, Michael Pennick Shire, Basingstoke, UK Abstract: Lisdexamfetamine dimesylate (LDX) is approved as a once-daily treatment for attention-deficit/hyperactivity disorder in children, adolescents, and adults in some countries. LDX is a prodrug comprising d-amphetamine covalently linked to l-lysine via a peptide bond. Following oral administration, LDX is rapidly taken up from the small intestine by active carrier-mediated transport, probably via peptide transporter 1. Enzymatic hydrolysis of the peptide bond to release d-amphetamine has previously been shown to occur in human red blood cells but not in several other tissues. Here, we report that LDX hydrolytic activity resides in human red blood cell lysate and cytosolic extract but not in the membrane fraction. Among several inhibitors tested, a protease inhibitor cocktail, bestatin, and ethylenediaminetetra-acetic acid each
The history of mustard plus the different mustard types. Page 1 of a 7-page glossary of mustard terms; here. THE NIBBLE, Great Food Finds, is a gourmet food webzine with thousands of product reviews and recipes including the history of mustard. Sign up for the Top Pick Of The Week to get a product review, recipe and cooking video by email or RSS.
Lyrics to Death Magick For Adepts by Cradle Of Filth: Come distortured artists / Bitter things seek meaning / Even if theyre madness to
ADEPT is at the forefront of technological advances in food testing to help you secure food safety and to preserve your brand and well-earned reputation. Apart from testing for nutritional and proximate parameters we are also testing for microbiological analysis. We are doing the analysis of all the products as per PFA (Prevention of Food Adulteration) norms or according to customers specifications. We are also testing as per FSSAI norms.. ...
Lessons in Genuine Occultism and Paganism by Frater Marabas from the Sorcerers Apprentice Occult Bookshop, U.K. established 1975 in Leeds. Train with our trusted Adept and his unique secrets
CH421 Experiment 2. Nitration of Aniline: a three-step protecting group strategy to prepare p-nitroaniline - PDF
CH421 Experiment 2 Nitration of Aniline: a three-step protecting group strategy to prepare p-nitroaniline Reading: Organic Chemistry by John McMurry, 8e, Chapter Techniques: recrystallization,
Learn about the potential benefits of Mustard including contraindications, adverse reactions, toxicology, pharmacology and historical usage.
We,Suzhou City Xiangcheng Qingtai Fine Chemicals Co.,Ltd ,provide our product catalog : China 3-nitro-4-aminophenol, 3-nitro-4-hydroxyethylaminophenol, China 3-nitro-4-hydroxypropylaminophenol, 2-chloro-5-nitro aniline, China 2-methyl-6-chloro aniline,
SGSs CRAs and project managers are adept ensuring your clinical trials run as smoothly as possible. The SGS team assigned to your project will have direct, relevant experience and will be fully up to date with regulations, procedures and tools. Find out more about how we can help you.
Play thousands of online jigsaw puzzles for free. Choose from several different puzzle cuts ranging from 6 pieces to 1,008 pieces.
Other names: Benzenamine, N,N-bis(2-chloroethyl)-; Aniline, N,N-bis(2-chloroethyl)-; N,N-Bis(2-chloroethyl)aniline; «beta»,« ... beta»-Dichlorodiethylaniline; N,N-Di(2-chloroethyl)aniline; Lymphochin; Lymphocin; Lymphoquin; NCS-18429; A 14489; CB 1074; ...https://webbook.nist.gov/cgi/cbook.cgi?ID=C553275&Units=SI&Mask=FFFF
Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid...
... aniline mustard, chlorambucil,melphalan).. One class of nitrogen mustards is the aniline mustards. These compound have at least ... A specific aniline mustard group is the acridine carried aniline mustards (described in Gravatt, et al., J. Med. Chem. 34:1552 ... 1. structure-activity relationhips for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard ... An example of the components of a 9-aminoacridine carried aniline mustard appears below (where X is the linking group): ##STR5# ...http://www.patentgenius.com/patent/6410219.html
Alkylating antineoplastic agent - Wikipedia
... cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards". Anticancer Drug Des. 14 (3): ... Before their use in chemotherapy, alkylating agents were better known for their use as sulfur mustard, ("mustard gas") and ... A common myth holds that Goodman and Gilman were prompted to study nitrogen mustards as a potential treatment for cancer ... Goodman, Gilman, and others began studying nitrogen mustards at Yale in 1942, and, following the sometimes dramatic but highly ...https://en.wikipedia.org/wiki/Alkylating_antineoplastic_agent
These include aniline mustard analogs of antineoplaston A10 and Mannich bases of antineoplaston A10.[11,12] These analogs ...https://www.cancer.gov/about-cancer/treatment/cam/hp/antineoplastons-pdq
Antineoplastons (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI]
These include aniline mustard analogs of antineoplaston A10 and Mannich bases of antineoplaston A10.[11,12] These analogs ...https://www.rexhealth.com/rh/health-library/document-viewer/?id=ncicdr0000570132
[email protected]: Browsing Chemistry - Master's degree by Title
Cellular response to 11[beta]-dichloro, a novel aniline mustard-estradienone, in various prostate cancer cell lines ...http://dspace.mit.edu/handle/1721.1/7796/browse?rpp=20&order=ASC&sort_by=1&etal=-1&type=title&starts_with=C
Antineoplastons (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI] - North...
These include aniline mustard analogs of antineoplaston A10 and Mannich bases of antineoplaston A10.[11,12] These analogs ...https://www.nkch.org/patients-visitors/health-library/healthwise-document-viewer/?id=ncicdr0000570132
Antineoplastons (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI] -...
Antineoplastones (PDQ®) (Health professionals) | OncoLink
These include aniline mustard analogs of antineoplaston A10 and Mannich bases of antineoplaston A10. These analogs showed ... Nitrogen Mustard Nitrogen Mustard Nivolumab Nizoral® Nolvadex® Novantrone® Nplate® ...https://es.oncolink.org/profesionales-de-la-salud/nci/pqid-CDR00007834552
The Cytotoxicity of Benzaldehyde Nitrogen Mustard-2-Pyridine Carboxylic Acid Hydrazone Being Involved in Topoisomerase IIα...
B. I. Fedeles, A. Y. Zhu, K. S. Young et al., "Chemical genetics analysis of an aniline mustard anticancer agent reveals ... Preparation of Benzaldehyde Nitrogen Mustard-2-Pyridine Carboxyl Acid Hydrazone (BNMPH). Benzaldehyde nitrogen mustard-2- ... Nitrogen mustard as alkylating agent is one of the most useful drugs in cancer chemotherapy. Due to the lack of selectivity and ... demonstrated that nitrogen mustard can inhibit transcription and translation in a cell free system . We also observed Taq ...https://www.hindawi.com/journals/bmri/2014/527042/
Antineoplastons (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI]
QuantiChrom™ Peroxide Assay Kit | DIOX-250 | Universal Biologicals
6. Fedeles, BI et al (2011). Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the ... 6. Fedeles, BI et al (2011). Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the ... 6. Fedeles, BI et al (2011). Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the ... 6. Fedeles, BI et al (2011). Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the ...https://www.universalbiologicals.com/quantichromtm-peroxide-assay-kit-diox-250
Metallointercalators as Probes of DNA Recognition and Reactions - CHEMICAL BIOLOGY
For instance, the bulky metallointercalator was tethered to an aniline mustard known to form covalent adducts to 5-GNC-3 ... demonstrates preferential alkylation of mismatched over fully matched DNA at concentrations where untethered organic mustards ...http://schoolbag.info/chemistry/chemical_biology/94.html
Detection of cellular sialic acid content using nitrobenzoxadiazole carbonyl-reactive chromophores. - Semantic Scholar
Thus, the combination of periodate oxidation with aniline-catalyzed ligation (PAL) has become a viable method for detection of ... hydrazine and amino-oxy compounds with carbonyls has gained popularity as a detection strategy with the recognition of aniline ... Live cell labeling of native intracellular bacterial receptors using aniline-catalyzed oxime ligation.. Josep Rayo, Neri Amara ... A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue. Ivana Drienovská, Clemens ...https://www.semanticscholar.org/paper/Detection-of-cellular-sialic-acid-content-using-Key-Li/e2cfc556bab2aed090f88709b97bd9485c495507
Browsing Cancer Therapeutics by issue date
Nine new nitrogen mustard compounds derived from 2,6-difluoro-4-hydroxy- (3a-e) and 2,6-difluoro-4-amino- (4a-d) aniline were ... aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems. Niculescu-Duvaz, I; Scanlon, I; Niculescu-Duvaz, D ...https://repository.icr.ac.uk/handle/internal/4/browse?type=dateissued
BO-0742 Summary Report | CureHunter
... a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors ... a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors ... 04/18/2009 - "This is a preclinical study of BO-0742, a derivative of 3-(9-acridinylamino)-5-hydroxymethyl-aniline (AHMA) and N ... 04/18/2009 - "BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia ...http://www.curehunter.com/public/keywordSummaryC539194-BO-0742.do
Mitochondria-targeting theranostics | Biomaterials Research | Full Text
... which functions to quench a fluorescent probe and deactivate an aniline nitrogen mustard, and then released the fluorophore and ...https://biomaterialsres.biomedcentral.com/articles/10.1186/s40824-018-0145-7
List of MeSH codes (D02) - Wikipedia
... mustard gas MeSH D02.455.526.728.650 --- nitrogen mustard compounds MeSH D02.455.526.728.650.050 --- aniline mustard MeSH ... quinacrine mustard MeSH D02.455.526.728.650.913 --- uracil mustard MeSH D02.455.526.913 --- trihalomethanes MeSH D02.455. ... phosphoramide mustards MeSH D02.455.526.728.650.730.243 --- cyclophosphamide MeSH D02.455.526.728.650.730.243.250 --- ... propylbenzilylcholine mustard MeSH D02.092.877.883.333.780 --- succinylcholine MeSH D02.092.877.883.333.800 --- thiocholine ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)
Aniline poisoning | Article about aniline poisoning by The Free Dictionary
Find out information about aniline poisoning. a morbid condition caused by the action of poison on the body and accompanied by ... Another cause is immoderate or improper use of cotton, mustard, or other oilcake fodders containing traces of toxins. The ... Aniline poisoning , Article about aniline poisoning by The Free Dictionary https://encyclopedia2.thefreedictionary.com/aniline+ ... redirected from aniline poisoning). Also found in: Dictionary, Thesaurus, Medical. Poisoning. a morbid condition caused by the ...https://encyclopedia2.thefreedictionary.com/aniline+poisoning
Rick's Link of the Day - Topic
... mustard and medicine; as an ingredient and preservative of tobacco; in soaps and cosmetics; in the extraction of perfume from ... flowers; to impart elasticity to paper; in the preparation of leather; as a solvent for certain aniline colors; in the ... in the production of artificial oil of mustard; in the preparation of certain cements, and of copying-ink and blotting-pads; in ...http://biodiesel.infopop.cc/eve/forums/a/tpc/f/419605551/m/3687043873
This image is taken from United States Naval Medical Bulletin Vol. 13, Nos. 1-4, 1919
Prevention of blindness.- -Aniline poisoning. -Immigration,/p,. ,p class=MsoNormal style=margin-bottom:.0001pt;line-height: ... Treatment of mustard-gas poisoning.. -Conference on medico-military administration. -Illegitimacy in Norway.. - ...http://www.djibnet.com/photo/charleston/this-image-is-taken-from-united-states-naval-medical-bulletin-vol-13-nos-1-4-1919-48306236932.html
Western Homeseeker, volume 1, number 09 :: Books, Pamphlets and Ephemera from the University of Montana
... an aniline dye. A bright yellow color in powdered and prepared mustard, extract of lemon, noodles, etc., shows artificial ... an aniline dye. A bright yellow color in powdered and prepared mustard, extract of lemon, noodles, etc., shows artificial ... After boiling five minutes or more, remove the wool and if aniline dye was present, it is now held in solution in the water by ... Boil again and the second piece of wool will be dyed a brilliant color if an ani-line dye was present. The above test would ...http://cdm15018.contentdm.oclc.org/cdm/singleitem/collection/p16013coll56/id/107
Index of /dic/A
Aniline-mustard_1346.., 2009-02-08 10:47 8.3K Anthranilic-acid_134.., 2009-02-08 10:47 11K Antipyrine_1349.html 2009-02-08 10: ... Aniline-p-butyl-N-p-.., 2009-02-08 11:08 7.6K Aniline-NN-dimethyl-.., 2009-02-08 11:08 9.1K Anise-oil_2175.html 2009-02-08 11: ... Aniline-hydrogen-pht.., 2009-02-08 14:07 8.8K a-Cyano-m-hydroxycin.., 2009-02-08 14:08 9.3K a2-Dichloro-6-fluoro.., 2009-02-08 ... Aniline-Blue_1712.html 2009-02-08 12:35 8.2K Acid-Blue-80_1719.html 2009-02-08 12:35 8.7K Acid-Green-41_1718.html 2009-02-08 12 ...http://www.chemicaldictionary.org/dic/A/?C=M
Products | Portland Black Lipstick Co
The yellow is cheery, though a bit closer to bright yellow mustard than a lemon yellow. No aniline dyes were used in the ... Many bright orange lipsticks derive their color from aniline dyes, but our formula only uses natural colorants. Like all ... Most bright red lipsticks are made with aniline dyes, which we dont use in our formulas. Imitation Cherry is a beautiful, ...http://portlandblacklipstickco.com/products/?product_page=1
HFZY30EEBD|Oxygen Generating Respirators|Safe Escape| Soft Case|Safe Home Products
Mustard Gas Sarin Benzene Chlorine Acetone Alcohol Class Aniline class Carbon Disulphide Carbon Tetrachloride Cloroform Methyl ...https://www.safehomeproducts.com/shp2/product/safe-escape-oxygen-generating-self-rescue-respirator-soft-case-10/cs/smoke-hoods-oxygen-self-rescue-units-gas-masks/461545/461545.aspx