A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.
Oxidative enzyme which transforms p-nitroanisole into p-nitrophenol.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
An enzyme of the oxidoreductase class that catalyzes the formation of L-TYROSINE, dihydrobiopterin, and water from L-PHENYLALANINE, tetrahydrobiopterin, and oxygen. Deficiency of this enzyme may cause PHENYLKETONURIAS and PHENYLKETONURIA, MATERNAL. EC 1.14.16.1.
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).
Alkylating anti-neoplastic agent.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.
The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)
An examination of chemicals in the blood.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.
A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.
An enzyme catalyzing the oxidation of 2 moles of glutathione in the presence of hydrogen peroxide to yield oxidized glutathione and water. EC 1.11.1.9.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
A genus of RED ALGAE, in the family Gigartinaceae. The species Chondrus crispus is a source of CARRAGEENAN.
Restoration of integrity to traumatized tissue.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
A publication issued at stated, more or less regular, intervals.
3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
Dextro form of levorphanol. It acts as a noncompetitive NMDA receptor antagonist, among other effects, and has been proposed as a neuroprotective agent. It is also a metabolite of DEXTROMETHORPHAN.
The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Phenols substituted in any position by an amino group.

NO contribution to lipopolysaccharide-induced hepatic damage in galactosamine-sensitized mice. (1/47)

To investigate the role of nitric oxide (NO) in hepatitis-induced endotoxemia, we injected mice intraperitoneally with 250 mg/kg galactosamine (GalN) and 1 mg/kg lipopolysaccharide (LPS) separately and in combination. NO synthesis increased in a dose-dependent manner with LPS. NO generation at 5 hr after administration of LPS was greater than that at 24 hr. Enhancement of NO generation was demonstrated in mice administered GalN and LPS in combination. A nitrosyl-heme signal in 10,000 g supernatant of liver homogenate, due to cytochrome P450 (P450) combining with NO, NO-P450, was detected at more than ten hr and even more after administration of LPS by electron spin resonance (ESR) measurements at 77 degrees K. The strongest NO-P450 signal and most extreme elevation of aspartate oxoglutarate aminotransferase (AST), alanine oxoglutarate aminotransferase (ALT), and lactate dehydrogenase (LDH) in serum and of lysosomal enzyme activity in plasma were observed in the GalN + LPS group. Their potency was greater than in the 10 mg/kg LPS group, which was even greater than in the LPS 1 mg/kg group. The aniline hydroxylase activity was inversely proportional to NO-P450 signal intensity. It appears that NO might contribute to LPS-induced hepatic damage in GalN-sensitized mice through degeneration and inactivation of liver microsomal enzymes by binding P450 active sites.  (+info)

Studies on the cytochrome P450 (CYP)-mediated metabolic properties of miocamycin: evaluation of the possibility of a metabolic intermediate complex formation with CYP, and identification of the human CYP isoforms. (2/47)

Some macrolide antibiotics cause clinical drug interactions, resulting in altered metabolism of concomitantly administered drugs, via the formation of a metabolic intermediate (MI) complex with cytochrome P450 (CYP), or competitive inhibition of CYP. In this study, the possibility of MI complex formation by miocamycin (MOM) was assessed first. CYP contents and activities in rat liver microsomes were not affected and there were no detectable MI complexes after administration of MOM for either 3 or 10 days to rats. Furthermore, MOM did not form MI complexes in vitro even with microsomes from humans or dexamethasone-pretreated rats. Second, in vitro studies were conducted to identify the human CYP isoforms involved in four 14-hydroxylation reactions in the MOM metabolic pathway. The results showed that it was most likely CYP3A4 involved in the hydroxylations: 1) each hydroxylation in human liver microsomes from 10 different donors strongly correlated with testosterone 6 beta-hydroxylation; 2) each hydroxylation was essentially inhibited by ketoconazole and troleandomycin; 3) only cDNA-expressed CYP3A4 and CYP3A5 catalyzed the hydroxylations, and the activities of CYP3A5 were below 5% of those of CYP3A4; and 4) the apparent K(M) values obtained with native human liver microsomes were comparable with those obtained with cDNA-expressed CYP3A4. In conclusion, MOM is not an inhibitor of CYP via the formation of an MI complex. Moreover, CYP3A4 is mainly responsible for catalyzing the hydroxylation of MOM metabolites. Because CYP3A4 is the most abundant form of CYP in the liver and intestine, this isoform probably accounts for the majority of drug-MOM interactions observed in clinical practice.  (+info)

Studies on the evaluation of the toxicity of various salts of lead, manganese, platinum, and palladium. (3/47)

Preliminary studies have been conducted on various parameters in order to assess the possible and relative toxicities of a number of metallic salts. Upon oral administration in lethal-dose experiments, two soluble Pt4+ salts were more toxic than the other salts tested. Following intraperiotneal injection in lethal-dose experiments, PbCl2 was less toxic than several of the soluble or partially soluble salts of Pt4+, Pd2+, and Mn2+. An intake of a total of approximately 250 mg of Pt4+ per rat in the drinking fluid over a 30-day interval did not affect the activities of aniline hydroxylase and aminopyrine demethylase in rat liver microsomes. In rats receiving soluble Pt4+ salts in the drinking fluid, the highest concentration of Pt was found in the kidney and an appreciiable concentration was found in the liver.  (+info)

Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration. (4/47)

We investigated the potential of dietary saturated fatty acids to reverse alcoholic liver injury despite continued administration of alcohol. Five groups (six rats/group) of male Wistar rats were studied. Rats in groups 1 and 2 were fed a fish oil-ethanol diet for 8 and 6 weeks, respectively. Rats in groups 3 and 4 were fed fish oil and ethanol for 6 weeks before being switched to isocaloric diets containing ethanol with palm oil (group 3) or medium-chain triglycerides (MCTs, group 4) for 2 weeks. Rats in group 5 were fed fish oil and dextrose for 8 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, nuclear factor-kappaB (NF-kappaB) activation, and mRNAs for cyclooxygenase-2 (Cox-2) and tumor necrosis factor-alpha (TNF-alpha). Endotoxin in plasma was determined. The most severe inflammation and fibrosis were detected in groups 1 and 2, as were the highest levels of endotoxin, lipid peroxidation, activation of NF-kappaB, and mRNAs for Cox-2 and TNF-alpha. After the rats were switched to palm oil or MCT, there was marked histological improvement with decreased levels of endotoxin and lipid peroxidation, absence of NF-kappaB activation, and reduced expression of TNF-alpha and Cox-2. A diet enriched in saturated fatty acids effectively reverses alcohol-induced necrosis, inflammation, and fibrosis despite continued alcohol consumption. The therapeutic effects of saturated fatty acids may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased activation of NF-kappaB and reduced levels of TNF-alpha and Cox-2.  (+info)

Hepatic microsomal enzyme induction in rats fed varietal cauliflower leaves. (5/47)

Leaves from a standard, insect-susceptible cauliflower variety and an insect-resistant strain were formulated at either 10 or 25% into semipurified diets for male and female weanling rats. After 3 weeks, relative liver weights, microsomal protein, cytochrome P-450, and activities of hepatic microsomal aminopyrine N-demethylase, aniline hydroxylase, p-nitroanisole O-demethylase, and N-methylaniline N-demethylase were determined. Growth, feed intake, and feed efficiency of male rats were not affected by the inclusion of the dried cauliflower leaf in the diet. However, female rats exhibited a depressed feed intake and increased feed efficiency with cauliflower leaf supplemental diets. Relative liver weights increased with increasing percentage of cauliflower leaves in the diet. Hepatic microsomal enzyme response to cauliflower leaf supplementation of the diet was greater in males than in females. Only aniline hydroxylase activity remained unchanged by the test diets. Male rats showed significant increases in N- and O-demethylation with both the 10 and 25% cauliflower diets, and increased values for microsomal protein and cytochrome P-450 at the 25% supplemental level. Female rats did not show significant hepatic microsomal induction from cauliflower leaf consumption at the 10% level. However, cytochrome P-450 and the metabolism of aminopyrine and p-nitroanisole were enhanced by consumption of cauliflower leaves at 25% of their diet. None of the parameters tested in this study evidenced a difference between the two cauliflower cultivars fed to either sex.  (+info)

Differential mutagenicities of triamino benzenes against Salmonella typhimurium TA98 in the presence of S9 fractions from polychlorinated biphenyls-, phenobarbital- or 3-methylcholanthrene-pretreated rats, hamsters and mice. (6/47)

Mutagenicity of 6 aminobenzene derivatives against Salmonella typhimurium TA98 was studied in the presence of various S9 fractions. S9, which has been prepared form the livers of rats, hamsters and mice after pretreatment with different types of inducers; polychlorinated biphenyls, phenobarbital and 3-methylcholanthrene, was used as the methabolic activating enzyme in this mutation assay. The S9 fractions from 3-methylcholanthrene-treated rats and mice are most useful for mutation induction by the all aminobenzenes used. The mutagenic activity of the compounds was clearly correlated to 3-methylcholanthrene-induced cytochrome P-450. However, any significant correlation between aniline hydroxylase activity and the mutagenesis was not observed.  (+info)

The differential effects of chemical carcinogens on vitamin A status and on microsomal drug metabolism in normal and vitamin A-deficient rats. (7/47)

Male Sprague-Dawley rats were maintained on a vitamin A-deficient diet for 5 weeks. Although serum and hepatic levels of vitamin A were significantly lower at this time, no outward signs of vitamin A deficiency were present. Hepatic microsomal levels of cytochrome P-450 in the vitamin A-deficient animals were 70% that of the control animals. Of the three microsomal enzymes studied, ethylmorphine N-demethylase, aniline hydroxylase, and aminopyrine N-demethylase, only the last one was adversely affected by vitamin A deficiency. 3-Methylcholanthrene, phenobarbital, and 2-acetylaminofluorene had a greater inductive effect and cytochrome P-450 in vitamin A-deficient rats. 4-Dimethylaminoazobenzene treatment decreased in the level of cytochrome P-450 in control rats more than in deficieny rats. The hepatic concentration of vitamin A was significantly reduced in control rats that were given injections of 3-methylcholanthrene, 2-acetylaminofluorene, or phenobarbital. Benzo(a)pyrene and 4-dimethylaminoazobenzene had less effect.  (+info)

Difference between effects of chlorpromazine and perphenazine on microsomal phospholipids and enzyme activities in rat liver. (8/47)

The effects of acute administration of chlorpromazine (CPZ) and perphenazine (PPZ) on hepatic microsomal phospholipids (PLs) and enzyme activities in the male rat were examined in order to elucidate the relationship between individual PLs and drug-metabolizing activity. Cytochrome P-450 and aniline (AN) hydroxylation activity were initially decreased in CPZ-treated rats, but cytochrome P-450 subsequently recovered to a level not significantly different from the control and AN hydroxylation was markedly increased, while in PPZ-treated rats, they remained depressed. CPZ increased the activities of glycerophosphate acyltransferase (GPA) and choline phosphotransferase (CPT), while PPZ increased the activities of phosphatidate cytidylyltransferase (PCT), phosphatidate phosphohydrolase (PPH) and CPT. Concurrently, CPZ raised microsomal phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine-inositol (PSI) and sphingomyelin (SM), while PPZ increased PC and PE, but did not affect the levels of PSI and SM. Acyl components of phospholipids were also modified. CPZ significantly decreased the ratio of saturated to unsaturated fatty acids, particularly in the PC and PE fractions, while the effect of PPZ was only slight. The results imply that an increase of AN hydroxylation activity may involve the incorporation of unsaturated fatty acids into enzyme-associated PC and PE.  (+info)

Ethanol-inducible cytochrome P450 (P450IIE) is reported to be induced by ketosis. In the present study, the effects of a high fat diet on P450IIE induction and the relationship between ketone body concentration and P450IIE induction were studied by the following: 1) measurement of the activity of aniline hydroxylase, 2) immunoblot analysis for P450IIE protein, and 3) Northern blot analysis for P450IIE mRNA. The enzyme activities (aniline hydroxylase) in hepatic and renal microsomes were elevated about 2-3-fold by feeding with a high fat diet for 3 days. The increases in enzyme activities were also accompanied by 3-fold increases in immunoreactive P450IIE protein and its mRNA. In contrast, no differences were observed for the catalytic activities of N-alkoxyresorufin dealkylases or the amounts of immunoreactive P450IA and P450IIC, indicating a specific induction of P450IIE by high fat feeding. Furthermore, the increases in the levels of P450IIE mRNA correlated positively (r = 0.73) with plasma ...
TY - JOUR. T1 - Hepatic Microsomal Induction in Rat Liver. T2 - Heterogeneity of Response. AU - Kiernan, Thomas W. AU - LUISADA‐OPPER, A.. AU - ERTEL, NORMAN H.. PY - 1981/1/1. Y1 - 1981/1/1. N2 - Abstract: The concept that urinary 6‐hydroxycortisol excretion patterns reflect all microsomal enzyme activities remains a subject of controversy. Three different microsomal hydroxylase activities were therefore studied in rat liver after the animals were intoxicated with alcohol, phenobarbital, or a combination thereof. The activities of pentobarbital hydroxylase, aniline hydroxylase, and cortisol 6‐hydroxylase (the enzyme metabolizing cortisol to 6‐hydroxycortisol) were assayed simultaneously after each treatment. A heterogeneity of enzyme activities was noted. Cortisol 6‐hydroxylase activity did not parallel the activity patterns of the two other hydroxylases. The data suggest that before urinary 6‐hydroxycortisol excretion patterns can be utilized as an index of microsomal enzyme ...
Unscramble aniline, Unscramble letters aniline, Point value for aniline, Word Decoder for aniline, Word generator using the letters aniline, Word Solver aniline, Possible Scrabble words with aniline, Anagram of aniline
Aniline Aniline Other names PhenylamineAminobenzeneBenzenamine Identifiers CAS number 62-53-3 SMILES NC1=CC=CC=C1 Properties Molecular formula C6H7N Molar mass
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TY - JOUR. T1 - The kinetics of ethylmorphine N-demethylation in isolated hepatocytes. T2 - The effect of drug transport and oxygen concentration. AU - Erickson, R. R.. AU - Yu-Drent, P.. AU - Holtzman, J. L.. PY - 1982/1/1. Y1 - 1982/1/1. N2 - In previous studies we have observed that the K(m) for ethylmorphine N-demethylase was only 50 to 100 μM in the isolated hepatocyte as opposed to 250 to 340 μM in isolated microsomes. These data suggested that either the drug is actively transported into the cell or that the enzymes in the cell had a reduced turnover number. Our current study indicates that ethylmorphine is transported into the hepatocyte with a K(m) of 250 μM and Tm of 20 nmol/min 106 cells. On the basis of temperature and inhibitor studies, this would appear to be active transport. When the turnover number of the ethylmorphine N-demethylase was decreased by reducing the oxygen from 20% of the gas phase to 5%, the activity was partially uncompetitively inhibited with the K(m) ...
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Ive always heard that generally speaking, Aniline finished leathers are superior because they are usually reserved for full grain hides, and also that cheaper leathers would have a white/blue/gray center. But after receiving some samples of Aniline dyed leather from one of the better French tanne...
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Aniline-induced methemoglobinemia, loss of circulating blood cells, blood … Earlier we have shown that aniline exposure leads to increased nitration of proteins in the spleen. The damaged hemoglobin can not carry oxygen. Aniline can be toxic if ingested, inhaled, or by skin contact. Toxicol. Toxicol Appl Pharmacol. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. New insights into aniline toxicity: Aniline exposure triggers envelope stress and extracellular polymeric substance formation in. This study involves the relationship between the chemical structure and hemotoxic markers of aniline and its halogenated analogs. https://doi.org/10.1016/j.jhazmat.2019.121571. [http://dx. (. Aniline induces extracellular polymeric substance and aggregates formation in strain JA2. (, Induction of signal transduction cascades and activation of transcription factors AP-1 and NF-B. Epub 2010 Nov 8. Human cancer data are insufficient to ...
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N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride chemical properties, What are the chemical properties of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride 2508-72-7, What are the physical properties of N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,hydrochloride ect.
Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane. Like most volatile amines, it possesses the somewhat unpleasant odour of rotten fish. It ignites readily, burning with a smoky flame characteristic of aromatic compounds. Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
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Aniline Compounds are organic compounds, consisting of a phenyl group attached to an amine group, with a molecular formula (C6H5NH2)
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N-cyclopropyl-2-nitro-5-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]aniline; CAS Number: ; find Princeton BioMolecular Research, Inc.-PRIH93ED878D MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Product Name: 2,8-diiododibenzofuranFormula: C12H6OI2Weight: 419.98344SMILES: IC1=CC2C3=C(C=CC(I)=C3)OC=2C=C1CAS NO: 127-48-0 Product: Trimethadione &
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The effect of a 20-day administration of aminopyrine (600 mg kg-1) as well as two metabolites of aminopyrine, 4-aminoantipyrine (525 mg kg-1) and 4-acetamidoantipyrine (635 mg kg-1), on several hepatic, kidney and serum enzyme activities were investigated. In the aminopyrine-treated group, a pronounced induction of gamma-glutamyl transpeptidase was shown in the whole homogenate as compared to that in the hepatic microsomes. Serum gamma-glutamyl transpeptidase activity was also increased by administration of aminopyrine or 4-aminoantipyrine. No change in gamma-glutamyl transpeptidase activity was observed in kidney and hepatic cytosolic fractions. In all cases, 4-acetamidoantipyrine treatment showed no significant change in the enzyme activities tested. Under the same experimental condition, the amounts of cytochrome P-450 and b5, the activities of aminopyrine N-demethylase, aniline hydroxylase and carboxylesterase of liver microsomes were all induced in the aminopyrine- and ...
TY - JOUR. T1 - Vapor-Liquid Equilibria in the System of Toluene/Aniline, Aniline/Naphthalene, and Naphthalene/Quinoline. AU - Lee, Chang-Ha. AU - Chen, Quen. AU - Mohamed, Rahoma S.. AU - Holder, Gerald D.. PY - 1992/4/1. Y1 - 1992/4/1. N2 - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately correlated with the modified Peng-Roblnson equation of state by using density-dependent mixing rules. The binary interaction parameters and correction factors for the equation of state are reported at each isotherm. The presence of coal-derived solids in these binary systems did not influence any of the binary bubble pressures.. AB - Vapor-liquid equilibria for the aniline/naphthalene, toluene/aniline, and naphthalene/quinoline systems have been determined at 0-1500 kPa and 490-623 K by using a static equilibrium cell. The data can be accurately ...
D611 - 12(2016) Standard Test Methods for Aniline Point and Mixed Aniline Point of Petroleum Products and Hydrocarbon Solvents , aniline point, aromatics, mixed aniline point,,
You searched for: Country France Remove constraint Country: France County Corse-du-Sud Remove constraint County: Corse-du-Sud Family Fabaceae Remove constraint Family: Fabaceae Kingdom Plantae Remove constraint Kingdom: Plantae Order Fabales Remove constraint Order: Fabales Phylum or Division Magnoliophyta Remove constraint Phylum or Division: Magnoliophyta Scientific Name Genista aspalathoides Remove constraint Scientific Name: Genista aspalathoides ...
Phenytoin is extensively bound to plasma proteins and is prone to competitive displacement. Phenytoin is metabolized by hepatic cytochrome P450 enzymes CYP2C9 and CYP2C19, and is particularly susceptible to inhibitory drug interactions because it is subject to saturable metabolism. Inhibition of metabolism may produce significant increases in circulating phenytoin concentrations and enhance the risk of drug toxicity. Monitoring of phenytoin serum levels is recommended when a drug interaction is suspected.. Phenytoin is a potent inducer of hepatic drug-metabolizing enzymes. ...
34. Indigofera galegoides Candolle, Prodr. 2: 225. 1825. 假大青蓝 jia da qing lan Indigofera finlaysoniana Graham ex Ridley; I. mansuensis Hayata; I. uncinata Roxburgh.. Shrubs or shrublets, 1-2 m tall. Young branches angular, with appressed white or grayish brown medifixed symmetri-cally 2-branched trichomes, glabrescent. Stipules linear, 3-4 mm. Leaves ca. 20 cm, 11-25-foliolate; petiole and rachis with appressed white mixed brownish gray medifixed trichomes; petiole 1.5-3 cm; rachis adaxially grooved; stipels subulate, 0.5-1 mm; petiolules ca. 2 mm, with brown trichomes; leaflet blades opposite or subopposite, oblong to oblanceolate-oblong, 2-4 × 0.7-1.6 cm, membranous, both surfaces with appressed brown and white medifixed trichomes, midvein abaxially prominent and adaxially impressed, secondary veins 11 on each side of midvein, base broadly cuneate to rounded, apex rounded to acute and mucronate. Racemes 5-12 cm, densely flowered; peduncle and rachis with appressed white medifixed ...
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Earlier we demonstrated that meta-iodobenzylguanidine (MIBG), a specific inhibitor of arginine mono-ADP-ribosylation blocks proliferation and differentiation of chick skeletal myogenic cells in...
The Epigenase JMJD3/UTX Demethylase Activity/Inhibition Assay Kit (Fluorometric) is a complete set of optimized reagents, designed for measuring activity/inhibition of JMJD3 and UTX using nuclear extracts or purified enzymes...
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Consider a binary mixture of cyclohexane (BP ) and benzene (BP ) at . This mixture presents a minimum-boiling azeotrope. It is possible to break this azeotrope using aniline. The vapor-liquid equilibrium (VLE) behavior of the ternary mixture is described by a modified form of Raoults law with activity coefficients predicted by the Wilson model [1]. This Demonstration plots the pseudo-binary phase;
CH421 Experiment 2 Nitration of Aniline: a three-step protecting group strategy to prepare p-nitroaniline Reading: Organic Chemistry by John McMurry, 8e, Chapter Techniques: recrystallization,
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We,Suzhou City Xiangcheng Qingtai Fine Chemicals Co.,Ltd ,provide our product catalog : China 3-nitro-4-aminophenol, 3-nitro-4-hydroxyethylaminophenol, China 3-nitro-4-hydroxypropylaminophenol, 2-chloro-5-nitro aniline, China 2-methyl-6-chloro aniline,
Regimex™ d The structural formula (dextro form) is represented below: Each tablet for oral administration contains 25 mg of benzphetamine hydrochloride
Researchers are searching for ways to prevent the coronavirus from attaching to DPP-4 receptors, blocking it from invading and replicating within host cells.. 0 Comments. ...
The development of several hepatic microsomal drug-metabolizing enzyme activities in rats was studied in relation to its androgen dependence during the neonatal period. Rats with their androgen deprived during the neonatal period (female rats and male rats castrated at birth) respond less to androgen treatment at adulthood for the metabolism of aminopyrine, ethylmorphine and hexobarbital as compared to rats exposed to neonatal androgen (male rats, male rats castrated at birth but neonatally treated with androgen and male rats castrated at the age of 20 days). This difference in the degree of hepatic responsiveness, however, varied with the substrates: ethylmorphine N-demethylase activity was affected the most whereas aminopyrine N-demethylase and hexobarbital oxidase activities were only marginally affected. Furthermore, these differences in responsiveness seem to be a delayed event, since hepatic aminopyrine N-demethylase activity in rats castrated at birth did respond to androgen stimulation ...
The cytokine-mediated suppression of hepatic drug-metabolizing enzymes by inflammatory disease and the relief of this suppression by successful disease treatment have recently become an issue in the development of drug interaction labels for new biological products. This study examined the effects of the inflammatory cytokine interleukin-6 (IL-6) on drug-metabolizing enzymes in human hepatocyte culture and the abrogation of these effects by a monoclonal antibody directed against IL-6. Treatment of human hepatocytes with IL-6 (n = 9 donors) revealed pan-suppression of mRNA of 10 major cytochrome P450 isoenzymes, but with EC50 values that differed by isoenzyme. Some EC50 values were above the range of clinically relevant serum concentrations of IL-6. Marker activities for CYP1A2 and CYP3A4 enzyme were similarly suppressed by IL-6 in both freshly isolated and cryopreserved hepatocytes. IL-6 suppressed induction of CYP1A2 enzyme activity by omeprazole and CYP3A4 enzyme activity by rifampicin but ...
DNA Demethylase Activity/Inhibition Assay Kit is use for measuring DNA demethylase activity/inhibition. (KA0677) - Products - Abnova
ETHNOPHARMACOLOGICAL RELEVANCE: Shikonin, a naphthoquinone pigment abundant in the root of the Chinese herb Lithospermum erythrorhizon, has been widely used to treat inflammatory diseases for thousands of years. Whether shikonin changes drug metabolism remains unclear. AIM OF THE STUDY: We investigated whether shikonin modulates the expression of hepatic drug-metabolizing enzymes and transporters as well as the possible mechanisms of this action. MATERIALS AND METHODS: Primary hepatocytes isolated from Sprague-Dawley rats were treated with 0-2 μM shikonin and the protein and mRNA levels of drug-metabolizing enzymes and transporters as well as the activation of aryl hydrocarbon receptor (AhR) and NF-E2-related factor 2 (Nrf2) were determined ...
TY - JOUR. T1 - Intermediates in the reaction of aniline with formaldehyde catalyzed by acids. AU - Bochkarev, V. V.. AU - Soroka, L. S.. PY - 2000/5/1. Y1 - 2000/5/1. N2 - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the semiempirical MNDO method. According to the calculation results, protonated N-(hydroxymethyl)aniline and ortho-, meta-, and paraσ-complexes are formed through the ion-dipole complex. Further transformations of these intermediates, which determine the structure of the final products, depend on the possibility of proton abstraction from the σ-complexes with formation of a quinonimine structure, as well as on the lability of the hydroxymethyl group in the protonated amino alcohol.. AB - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the ...
Add to Cart #01 Canola Yellow Eggshell Pysanka Dye. Treat with beeswax, such as Skidmores. I assume this is why it was stopped being used in the 60s guitar making? My original 14 bike was stolen. Hello, It has been many years since I have used Lee Valley Aniline Dyes. It was derived from coal tar and produced a deep purple color; mauve. Also produced a collection of new colors but identifying new commercialy viable aniline base dyes is di ï¬ cult. Ukrainian Easter Eggs (Pysanky) love vivid colours! 5. 1951. Do not use Indian dye or other water-based dyes. leather furniture showroom for â ¦ 127 Followers, 126 Following, 824 pins - See what Gabriela Dadario (dadario001) has discovered on Pinterest, the worlds biggest collection of ideas. Either an alcohol- or oil-based aniline dye. Aniline Water Stains. $1.60 CAD Qty. Gift of Joyce and Fred Zemans, 2008. This legendary 5 color guitar dye kit contains the rich, and vibrant primary dye colors of Red, Black, Yellow, Brown and Blue per every ...
Certain phenols and anilines can be used as electron transfer agents to increase the rate of oxidation of leuco dyes by peroxidase. These phenols and anilines can react with hydrogen peroxide in the presence of peroxidase to provide intermediates which have higher oxidation potentials than the slowly oxidized substrates, e.g. the leuco dyes. These phenols and anilines can be used to advantage in both solution and dry assays of various analytes. They are particularly useful for the determination of an immunologically reactive ligand in an immunoassay.
The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
Benzphetamine is a stimulant that is similar to an amphetamine. Benzphetamine is an appetite suppressant that affects the central nervous system. Benzphetamine is used together with diet and exercise to treat obesity (overweight). Benzphetamine may also be used for purposes not listed in this medication guide.
পুরাকালে মিশর, গ্রিস ও রোমের লোকেরাও নীলের কথা জানতো। মিশরের ১৮তম রাজবংশের মমি গুলি নীলরং এর কাগজে মোড়া থাকতো। বাংলা ভূখন্ডে ইন্ডিগোফেরা এর ১৫ প্রজাতির গাছ জন্মে। তার মধ্যে indigofera tinctoria নীল রং এর চাষ করা হতো ভারতে। নীল পানিতে দ্রব্য গুকোসাইড নামক রাসায়নিক হিসাবে থাকে। এই উপমহাদেশের মাটি নীল চাষের জন্য বিশেষ উপযোগী হওয়ায় ব্রিটিশ নীল করেরা বিপুল পুঁজি বিনিয়োগ করে নীলচাষে। ...
To start, 25 to 50 mg once a day. Usually taken in midmorning or midafternoon. The dose can be increased up to 150 mg per day, taken in 3 doses, if necessary and if the patient can tolerate this dosage without severe side effects. The magnitude of the increased weight loss associated with benzphetamine is a fraction of a pound a week, with the weight loss greatest in the first weeks of therapy ...
This site lists all substances and their properties which are reported on in the indexed Landolt-Börnstein volumes. In total, 160 000 organic and inorganic compounds are described by names, molecular structures, chemical abstract numbers and other identifiers. Properties are directly linked to the full documents at Springerlink. Landolt-Börnstein citations are given as Vol. LB-Group/Volume Chapter: number [, page]: document title and have a hyperlink to the full-text of the document containing the substance. The short identifier of the LB volume leads to a complete denotation of the reference with a direct link to the respective volume. For several compounds crosslinks to some derivatives are provided, e.g. isotope-marked compounds, hydrates and hydrochlorides. For benzenamine (aniline) for example there is a direct link to the related compounds benzenamine-d7 and aniline hydrochloride/hydrobromide/hydroiodide. Additionally, EINECS numbers (European Inventory of Existing Commercial Chemical ...
Zhejiang Weihua Chemical Co.,Ltd. is specialized in technology development, chemical manufacturer and trading. Our main products are benzotrifluoride series, total capacity is about 18000mt per year. Including p-chlorobenzotrifluoride is 10000mt annually, 3,4-Dichlorobenzotrifluoride 3000mt annually, etc.
HOPA = Hemalaun, Orange G, Phosphormolybdenic acid, Aniline blue Cell nuclei are stained with hemalaun or Weigerts iron-hematoxylin and then counterstained with a dye mixture of orange-phosphormolybden with aniline blue.. ...
Synonyms for anilide in Free Thesaurus. Antonyms for anilide. 3 synonyms for aniline: aminobenzine, aniline oil, phenylamine. What are synonyms for anilide?
Signs of the Side-chain Spin Couplings in Furans. II. 2-Methyl- and 3-Methylfuran, 2-Furfurylidenemalononitrile, and N-(2-Furfurylidene)aniline.. Rodmar, S ren; Fors n, Sture; Gestblom, Bo; Gronowitz, Salo; Hoffman, Ragnar A. ...
... aniline hydroxylase MeSH D12.776.422.220.453.040.110 - benzopyrene hydroxylase MeSH D12.776.422.220.453.040.332 - cytochrome p- ... steroid 11-beta-hydroxylase MeSH D12.776.422.220.453.915.730 - steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - ... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
... aryl hydrocarbon hydroxylases MeSH D08.244.453.040.050 - aniline hydroxylase MeSH D08.244.453.040.110 - benzopyrene hydroxylase ... aniline hydroxylase MeSH D08.811.682.690.708.170.040.110 - benzopyrene hydroxylase MeSH D08.811.682.690.708.170.040.332 - ... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 - steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 - steroid 16-alpha ... hydroxylase MeSH D08.244.453.915.748 - steroid 17-alpha-hydroxylase MeSH D08.244.453.915.760 - steroid 21-hydroxylase MeSH ...
Exposure was primarily to o-toluidine and aniline and a significant increase in incidences of bladder cancer was observed. ... Exposure to o-toluidine enhances the microsomal activity of aryl hydrocarbon hydroxylase (particularly in the kidney), NADPH- ...
Serotonin is synthesized from tryptophan by tryptophan hydroxylase, and then further by decarboxylase. A lack of 5-HT at ... Basophilic dyes such as aniline or (weakly) haematoxylin highlight negatively charged components, and so bind to the phosphate ...
It has also been identified in vitro as a strong inhibitor of CYP27A1 (cholesterol 27-hydroxylase) and as an inhibitor of ... or aniline, a diarylpropionamide, and a toluidide. First-generation NSAAs including bicalutamide, flutamide, and nilutamide are ... CYP46A1 (cholesterol 24-hydroxylase), but this has yet to be assessed or confirmed in vivo or in humans and the clinical ...
... metabolizes mostly small, polar molecules, including toxic laboratory chemicals such as dimethylformamide, aniline, and ... "Replacement of Thr-303 of P450 2E1 with serine modifies the regioselectivity of its fatty acid hydroxylase activity". Journal ...
Aniline Hydroxylase Assay.. Aniline hydroxylase assays were performed as described previously (Imai et al., 1966; Waxman et al ... The activity of aniline hydroxylase, which reflects the activity of CYP 2E1 (Lieber, 1997) decreased about 50% with ... containing 8 mM aniline and 1 mM NADPH. Reactions were terminated with 90 μl of 40% trichloroacetic acid. Samples were then ...
In rats treated with a single dose [50 mg/kg] of SKF 525-A, aminopyrine N-demethylase and aniline hydroxylase activities were ... M, in single and multiple doses on hypatic microsomal aminopyrine n-demethylase and aniline hydroxylase activities in the rat: ... demethylase and aniline hydroxylase were evaluated in rats. Two groups of rats treated with SKF 525-A, were used to demonstrate ...
Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples. ... Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many ... Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. ... Steroid hydroxylase activity. Specific Function. Metabolizes several precarcinogens, drugs, and solvents to reactive ...
Steroid 16-alpha-Hydroxylase* * Steroid Hydroxylases / genetics * Steroid Hydroxylases / metabolism Substances * Aniline ... The activation of POD activity in human liver microsomes by alphanaphthoflavone was inhibited by 100 microM aniline, anti- ...
Appendix D 259 transaminase, and aniline hydroxylase activity at all doses. Males had significantly decreased glutathione at ...
M.W. Anders, Acetone enhancement of microsomal aniline para-hydroxylase activity, Arch. Biochem. Biophys. 126: 269-275 (1968). ... M.-T. Huang, R.L. Chang, and A.H. Conney, Studies on the mechanism of microsomal benzo(a)pyrene hydroxylase activity by 7,8- ... F.J. Wiebel, J.C. Leutz, L. Diamond and H.V. Gelboin, Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in microsomes from rat ... F.J. Wiebel and H.V. Gelboin, Aryl hydrocarbon (benzo(a)pyrene) hydroxylases in liver from rats of different age, sex and ...
The apparent aniline/microsomal dissociation constants were not significantly affected. The type-I difference spectrum seen ... The effects on aminopyrine-demethylase and acetanilide-hydroxylase activity were evaluated. The extracts were examined by thin ... Isooctane did not inhibit aminopyrine-demethylase or acetanilide-hydroxylase activity. TLC spots corresponding to ... and the extent of aniline/microsomal binding. The effect on the hexobarbital binding spectrum of the preparations was ...
... benzphetamine N-demethylase and aniline hydroxylase. Furthermore, captan is a potent inhibitor of liver and intestinal ... microsomal aryl hydrocarbon hydroxylase in rats (Dalvi, 1989). The carbonyl sulfide derived during the metabolism of captan may ...
Glucose-6-phosphatase, paranitroanisole demethylase (pNaD) and aniline hydroxylase (AHase) activities in liver microsomes were ... and aniline hydroxylase (AHase) activities determined. The expected elevation of pNaD (5X) and AHase (3X) occurred with ...
Aniline Hydroxylase - metabolism. en_HK. dc.subject.mesh. Animals. en_HK. dc.subject.mesh. Central Nervous System Depressants ...
In copper deficient rats, a significant decrease in liver aniline hydroxylase activity was observed at 21 days and continued ... while liver aniline hydroxylase activity was reduced in the 450ppm group to approximately 20 percent of the control value at ... The reduction of the metabolism of aniline in-vitro and the metabolism of hexobarbitol both in-vitro and in-vivo was reversed ... In copper loaded rats, liver glucose 6- phosphatase and benzpyrene-hydroxylase activities were not significantly changed, ...
Properties of salicylate hydroxylase and hydroxyquinol 1,2-dioxygenase purified from Trichosporon cutaneum. J. Bacteriol. 159: ... Strain AK-5 Differs from That of Aniline and Aniline with C-4 Substituents. Shinji Takenaka, Susumu Okugawa, Maho Kadowaki, ... b) Metabolic pathways of aniline and aniline derivatives in Rhodococcus erythropolis AN-13 (2), Pseudomonas putida mt-2 (12), ... strain AK-5 and comparison to the metabolic pathways of aniline and aniline derivatives. (a) Proposed pathway of 4-aminophenol ...
Aniline 4-hydroxylase activity was monitored by the formation of 4-aminophenol as described elsewhere (Murray and Ryan, 1982). ... This is not unlike the situation with rat liver CYP2C13, which is a steroid 6β-hydroxylase in its purified state, but does not ... 1988) In vitro inhibition of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines ... It is also evident from figure 3 that aniline 4-hydroxylation was refractory to inhibition by parathion. ...
Evaluation of Lesion Scoring and Aniline Hydroxylase Activity in Hepatocarcinogenesis Rats Treated with Strobilanthes crispus ...
prolyl hydroxylase inhibitors... US-9,598,369. Process for the preparation of amides from hindered anilines containing a ... Prolyl hydroxylase inhibitors and methods of use. The present disclosure relates to HIF-1.alpha. prolyl hydroxylase inhibitors ... The present invention provides a novel and improved process for the production of the production of hindered anilines ...
The formation of 2-Methoxyethanol from Diglyme correlated with the aniline hydroxylase activity (P450 IIEI) levels measured in ...
Changes in certain kinetic properties of hepatic microsomal aniline hydroxylase and ethylmorphine demethylase associated with ...
... momordin Ic and oleanolic acid resulted in significantly lower production of aminopyrine N-demethylase and aniline hydroxylase ...
aniline synonyms, aniline pronunciation, aniline translation, English dictionary definition of aniline. also an·i·lin n. A ... ethylmorphine-N demethylase and aniline 4-hydroxylase) and soluble protein contents of a wheat grain pest, Trogoderma granarium ... anil + -ine.]. aniline. (ˈænɪlɪn; -ˌliːn) or anilin. n. (Elements & Compounds) a colourless oily pungent poisonous liquid used ... Monocyclic aromatic amines bring hazards to human health and aniline is one of them.. Molecular Characterization of Aniline ...
... aniline hydroxylase, bufuralol 1′-hydroxylase, and midazolam 1′-hydroxylase. On the other hand, activities of phenacetin O- ... aniline hydroxylase (AN), bufuralol 1′-hydroxylase (BF), and midazolam 1′-hydroxylase (MDZ), which are not catalyzed by human ... aniline hydroxylase; BF, bufuralol 1′-hydroxylase; MDZ, midazolam 1′-hydroxylase; 13X, caffeine 7-demethylase; 17X, caffeine 3- ... Aniline Hydroxylase Assay. Aniline (5 mM) was incubated for 30 min at 37°C in 1 ml of a reaction mixture consisting of 50 mM ...
Twenty-four hours after the final dose, their livers were examined for aniline hydroxylase activity, for levels of cytochromes ... cytochrome b5 and in the activity of aniline hydroxylase were found. In a subsequent study it was discovered that the effect ... prior to examination of their livers for aniline hydroxylase and aminopyrine demethylase activities, for levels of cytochromes ...
... in vitro activities of aniline hydroxylase and aminopyrine demethylase, content of cytochromes P-450 and b5/mg microsomal ...
... where there was a significant decrease in aniline hydroxylase activity. These data served as background for the ...
... biphenyl-4-hydroxylase, aniline hydroxylase, 4-methoxybiphenyl- N- demethylase, and cytochrome- c-reductase. The activities of ... pyrene hydroxylase, 7-ethoxycoumarin-deethylase, and cytosolic glutathione- S-transferase were measured. The activities of ...
... aniline hydroxylase MeSH D12.776.422.220.453.040.110 - benzopyrene hydroxylase MeSH D12.776.422.220.453.040.332 - cytochrome p- ... steroid 11-beta-hydroxylase MeSH D12.776.422.220.453.915.730 - steroid 12-alpha-hydroxylase MeSH D12.776.422.220.453.915.737 - ... steroid 16-alpha-hydroxylase MeSH D12.776.422.220.453.915.748 - steroid 17-alpha-hydroxylase MeSH D12.776.422.220.453.915.760 ... cholesterol 7 alpha-hydroxylase MeSH D12.776.422.220.453.915.212 - cholesterol side-chain cleavage enzyme MeSH D12.776.422.220. ...
... aryl hydrocarbon hydroxylases MeSH D08.244.453.040.050 - aniline hydroxylase MeSH D08.244.453.040.110 - benzopyrene hydroxylase ... aniline hydroxylase MeSH D08.811.682.690.708.170.040.110 - benzopyrene hydroxylase MeSH D08.811.682.690.708.170.040.332 - ... steroid 11-beta-hydroxylase MeSH D08.244.453.915.730 - steroid 12-alpha-hydroxylase MeSH D08.244.453.915.737 - steroid 16-alpha ... hydroxylase MeSH D08.244.453.915.748 - steroid 17-alpha-hydroxylase MeSH D08.244.453.915.760 - steroid 21-hydroxylase MeSH ...
Fauziah.O., P.Hanachi., S.Yogespiriya and R.Asmah (2005) Evaluation of lesion scoring and aniline hydroxylase activity in ...
  • The effects of diclofenac sodium administration , in single and repeated doses , on hepatic microsomal activities of aminopyrine N- demethylase and aniline hydroxylase were evaluated in rats . (bvsalud.org)
  • In rats treated with a single dose [50 mg/kg] of SKF 525-A, aminopyrine N-demethylase and aniline hydroxylase activities were significantly decreased, compared with control values. (bvsalud.org)
  • The effects on aminopyrine-demethylase and acetanilide-hydroxylase activity were evaluated. (cdc.gov)
  • Isooctane did not inhibit aminopyrine-demethylase or acetanilide-hydroxylase activity. (cdc.gov)
  • Hexobarbital hydroxylase, aminopyrene demethylase, benzpyrene hydroxylase and p-aminophenol aniline hydroxylase were stimulated. (cdc.gov)
  • Pretreatment with momordin Ic and oleanolic acid resulted in significantly lower production of aminopyrine N-demethylase and aniline hydroxylase in the CCl4-treated rats. (biomedsearch.com)
  • The present study was aimed to determine the toxic effect of phosphine on microsomal enzymes (NADPHCytochrome P450 reductase (NADPH-CPR), ethylmorphine-N demethylase and aniline 4-hydroxylase) and soluble protein contents of a wheat grain pest, Trogoderma granarium collected from godowns of Punjab, Pakistan. (thefreedictionary.com)
  • There was no statistical difference between C / C , C / T , and T / T dogs in activities of aminopyrine N -demethylase, aniline hydroxylase, bufuralol 1′-hydroxylase, and midazolam 1′-hydroxylase. (aspetjournals.org)
  • Also following dietary administration, hepatic microsomes were isolated and the following parameters related to in vitro drug metabolism were measured, yield of microsomal protein/g liver, in vitro activities of aniline hydroxylase and aminopyrine demethylase, content of cytochromes P-450 and b5/mg microsomal protein. (epa.gov)
  • Similarly, in a parallel group of rats that did not receive DMBA, the activities of aniline hydroxylase, aminopyrine N -demethylase, and cytochrome c reductase were not significantly altered by dietary selenium levels. (aacrjournals.org)
  • On stipulated day the animals were slaughtered, their livers taken out and microsomes prepared for the estimation of activities of various membrane bound DME such as cytochrome P450 (CP), cytochrome b5 (CB), cytochrome-c-reductase (CCR), aniline hydroxylase (AH), acetanilide hydroxylase (AAH), benzphetamine demethylase (BD), aminopyrine demethylase (APD), N. (thefreedictionary.com)
  • Administration of Zineb at doses from 200 to 600 mg/kg caused a significant impairment of aminopyrine-N-demethylase in the two species, as well as an inhibition of aniline hydroxylase in rats and a slight increase of this enzymatic activity in mice. (springer.com)
  • p-chloro-methly-aniline(PCMA)N- demethylase and p-nitrophenol UDP-glucuronyl transferase activities were unaltered by the feed restriction while cytochrome c reductase activity was significantly decreased. (tennessee.edu)
  • As shown in Table 1, [gamma]-HCH treatment resulted in a significant increase in hepatic microsomal NADPH cytochrome Creductase by 71%, while [gamma]-HCH decreased both amidopyrine N-demethylase and aniline-4-hydroxylase by 11 and 27%, respectively when compared to control. (freethesaurus.com)
  • 450s] (except hepatic amidopyrine N-demethylase and aniline 4-hydroxylase activities). (freethesaurus.com)
  • A significant inhibition of hepatic microsomal amidopyrine N-demethylase and aniline 4-hydroxylase activities observed in [gamma]-HCH intoxicated animals compared to control. (freethesaurus.com)
  • The enzymes investigated were aminopyrine N-demethylase, aniline 4-hydroxylase and UDP-glucuronyltransferase. (termsreign.ga)
  • The content of microsomal cytochromes P-450 and 5 the activity of N-demethylase amidopirina and p-aniline hydroxylase was calculated per 1 mg of microsomal protein. (russianpatents.com)
  • PSK had no influence on aminopyrine N-demethylase and aniline hydroxylase activities, cytochrome P-450 concentration in hepatic microsomes, and the reductase activity of cytochrome c in normal mice. (mushroomstudies.co)
  • In the present study the toxic effects of TCE inhalation on pulmonary and hepatic biotransformation enzymes in rats have been investigated by assay of aniline hydroxylase (AH), aminopyrine-N-demethylase (APD), benzo-a-pyrene hydroxylase (BH) and glutathione-s-transferase (GST) activities and glutathione (GSH) contents in liver as well as lungs of exposed animals. (who.int)
  • The activities of NADPH-CPR, ethylmorphine-N demethylase, aniline 4-hydroxylase and soluble protein contents were significantly increased in all field collected phosphine-tolerant populations with reference to phosphine-susceptible population. (researcherslinks.com)
  • Then, aminopyrine N-demethylase, aniline 4-hydroxylase, aromatase, caffeine N-demethylase, cytochrome b5 reductase, erythromycin N-demethylase, ethoxyresorufin O-deethylase, glutathione S-transferase, N-nitrosodimethylamine N-demethylase and penthoxyresorufin O-deethylase activities were determined to follow changes in the activity of drug metabolizing enzymes in SOX-deficient rats. (agu.edu.tr)
  • In contrast to P-450 3 and steroid 5α-reductase, however, the elevation of P-450j protein was transient and was not accompanied by an increase in P-450j-associated hepatic microsomal aniline hydroxylase activity. (aacrjournals.org)
  • The activation of POD activity in human liver microsomes by alphanaphthoflavone was inhibited by 100 microM aniline, anti-CYP2E1 antibody, 1 microM ketoconazole and anti-CYP3A4 antibody. (nih.gov)
  • The formation of 2-Methoxyethanol from Diglyme correlated with the aniline hydroxylase activity (P450 IIEI) levels measured in human hepatic microsomes. (europa.eu)
  • P-450-mediated cyclophosphamide 4-hydroxylase activity in isolated rat liver microsomes decreased by approximately 70% over a 9-day period following drug treatment. (aacrjournals.org)
  • The enzyme activities (aniline hydroxylase) in hepatic and renal microsomes were elevated about 2-3-fold by feeding with a high fat diet for 3 days. (aspetjournals.org)
  • Aniline hydroxylase from liver microsomes of rainbow trout Salmo gairdneri converted aniline to p-aminophenol, the specific activity being 0.068 nmoles/min/mg protein in potassium phosphate buffer, pH 7.4 at 25 degrees C. The maximal rate of the enzyme reaction was found at aniline concentrations above 5 mM and in the presence of NADPH. (bvsalud.org)
  • The activity of compounds was evaluated by the test geksenalovy sleep, the content of cytochrome P-450 in liver microsomes, the metabolic rate of substrate type I - amidopirina and substrate type II - aniline. (russianpatents.com)
  • In microsomes was determined by the level of cytochromes P-450 and 5 metabolism amidopirina was assessed by the formation of formaldehyde in the incubation media, the p-hydroxylation of aniline - education p-aminophenol. (russianpatents.com)
  • Antibody to rabbit ethanol-inducible cytochrome P-450 (isozyme 3a) inhibited over 80% of the aniline (high affinity) and p-nitrophenol hydroxylase activities of microsomes from ethanol-treated hamsters. (elsevier.com)
  • A comparison of the antibody-inhibitable rates for both hydroxylase activities with microsomes from untreated, ethanol- or phenobarbital-pretreated hamsters suggested that an isozyme homologous to rabbit isozyme 3a (hamster cytochrome P-450alc) was induced in hamsters about 3.5-fold by ethanol and was unaffected by phenobarbital. (elsevier.com)
  • Although, p-nitrophenol hydroxylase and aniline 4-hydroxylase activities were markedly enhanced by pyridine treatment in liver about 4.4- and 5.8-fold, respectively, no change was observed in the activities of these enzymes in lung microsomes. (metu.edu.tr)
  • The metabolism of Aniline can be decreased when combined with Clotrimazole. (drugbank.ca)
  • The reduction of the metabolism of aniline in-vitro and the metabolism of hexobarbitol both in-vitro and in-vivo was reversed by restoration of copper to the diet. (cdc.gov)
  • Metabolism of aniline by Rhodococcus erythropolis AN-13. (microbiologyresearch.org)
  • The effects of ethanol and of phenobarbital pretreatment on hamster microsomal metabolism of aniline and p-nitrophenol have been investigated. (elsevier.com)
  • In copper loaded rats, liver glucose 6- phosphatase and benzpyrene-hydroxylase activities were not significantly changed, while liver aniline hydroxylase activity was reduced in the 450ppm group to approximately 20 percent of the control value at both 15 and 30 days. (cdc.gov)
  • In copper deficient rats, a significant decrease in liver aniline hydroxylase activity was observed at 21 days and continued throughout the 42 day test period. (cdc.gov)
  • As for endogenous substances, our results indicated that human CYP1A2, but not dog CYP1A2, is responsible for melatonin 6-hydroxylase, 9- cis -retinal oxidase, and estradiol 2-hydroxylase activity. (aspetjournals.org)
  • The most noteworthy changes occurred in the males exposed to the highest level of DCE, where there was a significant decrease in glutathione levels, and in the females exposed to all three DCE levels, where there was a significant decrease in aniline hydroxylase activity. (epa.gov)
  • CYP17A1 has both 17α-hydroxylase activity and 17,20-lyase activity. (creativebiomart.net)
  • The 17α-hydroxylase activity of CYP17A1 is necessary for the production of glucocorticoids (such as cortisol), but the hydroxylase and 17,20-lyase activity of CYP17A1 is achieved by converting 17α-hydroxypregnenolone to Hydroepiandrosterone is required to produce androgens and estrogen steroids (DHEA). (creativebiomart.net)
  • In the present study, the effects of a high fat diet on P450IIE induction and the relationship between ketone body concentration and P450IIE induction were studied by the following: 1) measurement of the activity of aniline hydroxylase, 2) immunoblot analysis for P450IIE protein, and 3) Northern blot analysis for P450IIE mRNA. (aspetjournals.org)
  • Expression of P4HA2 was silenced by shRNAs, and its activity was inhibited by 1, 4-DPCA, a prolyl-4-hydroxylase inhibitor. (biomedcentral.com)
  • Because 4-hydroxyproline residues formed in this reaction are essential for triple helix formation and stabilization of collagen [ 22 - 24 ], inhibiting the prolyl-4-hydroxylases activity efficiently blocks collagen synthesis and deposition. (biomedcentral.com)
  • Cortisol 6‐hydroxylase activity did not parallel the activity patterns of the two other hydroxylases. (elsevier.com)
  • High concentrations of phenol significantly inhibited the activity of phenol hydroxylase, but had no obvious effect on catechol dioxygenase. (springer.com)
  • Female diabetic rats exhibited no change in benzo[a]pyrene hydroxylase activity, a decrease in testosterone A⁴ hydrogenase, and an increase in aniline hydroxylase. (ubc.ca)
  • All metal salts did not change the metabolizing activity of aniline hydroxylase which confirm that multiple molecule species of cytochrome P-450 exist in the liver of adult rats. (saladgaffe.ga)
  • The increased activity of liver aniline hydroxylase observed 12 hr after the administration of FAA, AZP, or DEN decreased when AZP was administered simultaneously with FAA to rats treated with DEN in advance. (pianolarge.ml)
  • Testosterone 6β-hydroxylation (mediated by CYP3A4), 7-ethylresorufin O -deethylation (CYP1A2) and tolbutamide methyl hydroxylation (CYP2C9/10), but not aniline 4-hydroxylation (CYP2E1), were inhibited effectively by parathion. (aspetjournals.org)
  • Hydroxylases are present in reactions such as the synthesis of steroids (squalene hydroxylase) from squalene (squalene) and hydroxylation of steroids (various steroid hydroxylases). (creativebiomart.net)
  • This decrease was due to the loss of cytochrome P-450 form 2c (IIC11), a major contributor to cyclophosphamide 4-hydroxylation in untreated male rat liver, while the other major hepatic cyclophosphamide 4-hydroxylase, P-450 PB-1 (IIC6), was largely unaffected. (aacrjournals.org)
  • Comparison of the specific activities for aniline hydroxylation and p-nitrophenol hydroxylation of individual microsomal samples from control, ethanol-pretreated and phenobarbital-pretreated animals showed a high degree of correlation r 2 = 0.98) consistent with the involvement of the same site for catalysis of these two compounds. (elsevier.com)
  • This isozyme can be readily monitored by either high-affinity aniline or p-nitrophenol hydroxylation or by Western immunoblot analysis and appears to be the ethanol-inducible form of cytochrome P-450 in hamsters. (elsevier.com)
  • Several publications have briefly reported on benzpyrene hydroxylase without specifying the site of hydroxylation. (ormedmedical.us)
  • Twenty milliliters (ml) microsomal suspension were extracted with 13.4ml isooctane or unextracted and assayed for protein, cytochrome-b5, cytochrome-P450, and the extent of aniline/microsomal binding. (cdc.gov)
  • We have characterized the behavior under tension of the native state (N), and that of the ensemble of partially folded (PF) conformations the protein visits en route to N, which collectively act as a long-lived state controlling the slow kinetic phase of the folding process. (termsreign.gq)
  • Collagen biosynthesis is a multistep process that involves several post-transcription modification enzymes, and one of the most important members of these enzymes is collagen prolyl-4-hydroxylase [ 16 ]. (biomedcentral.com)
  • Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. (drugbank.ca)
  • Monocyclic aromatic amines bring hazards to human health and aniline is one of them. (thefreedictionary.com)
  • Aromatic, aniline-like. (chemicalbook.com)
  • On the other hand, activities of phenacetin O -deethylase, ethoxyresorufin O -deethylase, and tacrine 1-hydroxylase, which were catalyzed by human CYP1A2, were significantly lower in T / T dogs than C / C dogs, indicating that dog and human CYP1A2 was responsible for these activities. (aspetjournals.org)
  • Three different microsomal hydroxylase activities were therefore studied in rat liver after the animals were intoxicated with alcohol, phenobarbital, or a combination thereof. (elsevier.com)
  • The activities of pentobarbital hydroxylase, aniline hydroxylase, and cortisol 6‐hydroxylase (the enzyme metabolizing cortisol to 6‐hydroxycortisol) were assayed simultaneously after each treatment. (elsevier.com)
  • The specific activities of phenol hydroxylase and catechol dioxygenase in I. galbana are measured. (springer.com)
  • Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. (drugbank.ca)
  • Biological testing of the compounds NN 10210791-10211091, EN zymes the soup xenobiotics, conducted baseline drug phenobarbital on white outbred mice-males and Wistar rats. (russianpatents.com)
  • Dopamine beta-hydroxylase catalyzes the conversion of dopamine to norepinephrine. (creativebiomart.net)
  • Dopamine is converted to norepinephrine by dopamine beta-hydroxylase. (creativebiomart.net)
  • The expression of dopamine β-hydroxylase (DβH) and Norepinephrine (NE) in sacrococcygeal skin were detected by immunohistochemistry and western blotting. (alliedacademies.org)
  • Benzo[a]pyrene hydroxylase kinetic studies did not reveal marked differences between control and diabetic rats. (ubc.ca)
  • The apparent aniline/microsomal dissociation constants were not significantly affected. (cdc.gov)
  • Mutations in this gene have been linked to isolated steroid-17α-hydroxylase deficiency, 17α-hydroxylase/17,20-lyase deficiency, pseudohermaphrodite and adrenal hyperplasia. (creativebiomart.net)
  • The serum concentration of Aniline can be decreased when it is combined with Cyproterone acetate. (drugbank.ca)
  • that their canned peas had been colored with copper salts, and their fruit jams with aniline dyes? (thefreedictionary.com)
  • In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. (thefreedictionary.com)
  • In the synthesis of tyrosine from phenylalanine, (phenylalanine hydroxylase) and aminophenol (aniline-4-hydroxylase) from aniline. (creativebiomart.net)
  • Dopamine β-hydroxylase (DBH), also known as dopamine β-monooxygenase, is an enzyme encoded by the DBH gene in humans. (creativebiomart.net)
  • The gene cluster involved in aniline oxidation was cloned in Escherichia coli JM109 from the total plasmid DNA of strain YAA. (microbiologyresearch.org)
  • The data suggest that before urinary 6‐hydroxycortisol excretion patterns can be utilized as an index of microsomal enzyme induction, the effect of the specific drug on individual cytochrome P‐450 hydroxylases is required. (elsevier.com)
  • A recombinant E. coli containing an 18.5 kb insert fragment showed yellow colouration on aniline-containing plates, indicating the formation of 2-hydroxymuconic semialdehyde from aniline. (microbiologyresearch.org)