Aniline CompoundsAniline Hydroxylase: A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.Aniline Mustard: Alkylating anti-neoplastic agent.ToluidinesAminophenols: Phenols substituted in any position by an amino group.Aminopyrine N-DemethylaseBiodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Delftia: A genus of gram-negative, strictly aerobic chemoorganotrophic bacteria, in the family COMAMONADACEAE.Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)Azo CompoundsHexobarbital: A barbiturate that is effective as a hypnotic and sedative.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Delftia acidovorans: A species of gram-negative rod-shaped bacteria found ubiquitously and formerly called Comamonas acidovorans and Pseudomonas acidovorans. It is the type species of the genus DELFTIA.Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.Propanil: A chlorinated anilide that is used as an herbicide.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.Ethylmorphine: A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.IminesPalladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Water Pollutants: Substances or organisms which pollute the water or bodies of water. Use for water pollutants in general or those for which there is no specific heading.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Oxidative Coupling: The reaction of two molecular entities via oxidation usually catalyzed by a transition metal compound and involving dioxygen as the oxidant.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Kinetics: The rate dynamics in chemical or physical systems.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Acetone: A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.o-Aminoazotoluene: An azo dye with carcinogenic properties.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Quinacrine Mustard: Nitrogen mustard analog of quinacrine used primarily as a stain in the studies of chromosomes and chromatin. Fluoresces by reaction with nucleic acids in chromosomes.Decontamination: The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Environmental Pollutants: Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.Water Pollutants, Chemical: Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.Xanthine: A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes. (1/1809)
1. The time courses of Ca2+ current and Ca2+ spark occurrence were determined in single rat ventricular myocytes voltage clamped with patch pipettes containing 0.1 microM fluo-3. Acquisition of line-scan images on a laser scanning confocal microscope was synchronized with measurement of Cd2+-sensitive Ca2+ currents. In most cells, individual Ca2+ sparks were observed by reducing Ca2+ current density with nifedipine (0.1-8 microM). 2. Ca2+ sparks elicited by depolarizing voltage-clamp pulses had a peak [Ca2+] amplitude of 289 +/- 3 nM with a decay half-time of 20.8 +/- 0.2 ms and a full width at half-maximum of 1.40 +/- 0.03 microm (mean +/- s. e.m., n = 345), independent of the membrane potential. 3. The time between the beginning of a depolarization and the initiation of each Ca2+ spark was calculated and data were pooled to construct waiting time histograms. Exponential functions were fitted to these histograms and to the decaying phase of the Ca2+ current. This analysis showed that the time constants describing Ca2+ current and Ca2+ spark occurrence at membrane potentials between -30 mV and +30 mV were not significantly different. At +50 mV, in the absence of nifedipine, the time constant describing Ca2+ spark occurrence was significantly larger than the time constant of the Ca2+ current. 4. A simple model is developed using Poisson statistics to relate macroscopic Ca2+ current to the opening of single L-type Ca2+ channels at the dyad junction and to the time course of Ca2+ spark occurrence. The model suggests that the time courses of macroscopic Ca2+ current and Ca2+ spark occurrence should be closely related when opening of a single L-type Ca2+ channel initiates a Ca2+ spark. By comparison with the data, the model suggests that Ca2+ sparks are initiated by the opening of a single L-type Ca2+ channel at all membrane potentials encountered during an action potential. (+info)RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/1809)
Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications. (+info)Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/1809)
Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia. (+info)Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. (4/1809)
Myeloperoxidase is the most abundant protein in neutrophils and catalyzes the production of hypochlorous acid. This potent oxidant plays a central role in microbial killing and inflammatory tissue damage. 4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation. We have investigated the mechanism by which benzoic acid hydrazides (BAH) are oxidized by myeloperoxidase, and we have determined the features that enable them to inactivate the enzyme. BAHs readily reduced compound I of myeloperoxidase. The rate constants for these reactions ranged from 1 to 3 x 10(6) M-1 s-1 (15 degrees C, pH 7.0) and were relatively insensitive to the substituents on the aromatic ring. Rate constants for reduction of compound II varied between 6.5 x 10(5) M-1 s-1 for ABAH and 1.3 x 10(3) M-1 s-1 for 4-nitrobenzoic acid hydrazide (15 degrees C, pH 7.0). Reduction of both compound I and compound II by BAHs adhered to the Hammett rule, and there were significant correlations with Brown-Okamoto substituent constants. This indicates that the rates of these reactions were simply determined by the ease of oxidation of the substrates and that the incipient free radical carried a positive charge. ABAH was oxidized by myeloperoxidase without added hydrogen peroxide because it underwent auto-oxidation. Although BAHs generally reacted rapidly with compound II, they should be poor peroxidase substrates because the free radicals formed during peroxidation converted myeloperoxidase to compound III. We found that the reduction of ferric myeloperoxidase by BAH radicals was strongly influenced by Hansch's hydrophobicity constants. BAHs containing more hydrophilic substituents were more effective at converting the enzyme to compound III. This implies that BAH radicals must hydrogen bond to residues in the distal heme pocket before they can reduce the ferric enzyme. Inactivation of myeloperoxidase by BAHs was related to how readily they were oxidized, but there was no correlation with their rate constants for reduction of compounds I or II. We propose that BAHs destroy the heme prosthetic groups of the enzyme by reducing a ferrous myeloperoxidase-hydrogen peroxide complex. (+info)A comparison of electron-capture GLC, electrolytic-conductivity GLC and UV-absorption HPLC for the analysis of some herbicides in foods. (5/1809)
A comparison of gas chromatography with electron-capture or electrolytic-conductivity (nitrogen mode) detection, and high-pressure liquid chromatography (HPLC) with UV-absorption detection (254 nm) was carried out for the analysis of several herbicides in foods. Linuron, propanil, terbacil, benzoylprop-ethyl, and the fungicide DCNA in samples of cabbage, corn, potato, and wheat spiked at 2 and 0.2 ppm were examined. The pesticides were extracted with acetone, partitioned into petroleum ether-methylene chloride, and cleaned up on a 2% deactivated Florisil column before direct chromatographic analysis. Electron-capture gas-liquid chromatography (GLC) was most suitable for DCNA and benzoylprop-ethyl while UV-absorption HPLC was best for terbacil analysis. Linuron and propanil gave similar results for both electron-capture GLC and HPLC. Electrolytic-conductivity GLC could detect all pesticides at the 0.2 ppm level and exhibited the least number of extraneous peaks in the chromatograms. (+info)Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (6/1809)
We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver. (+info)Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. (7/1809)
We investigated the effects of a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl)ureido]methyl]cyclohexane), on ACAT activities in macrophages originating from several species and high-density lipoprotein (HDL)-induced cholesterol efflux in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells. NTE-122 inhibited cell-free ACAT activities in human PMA-treated THP-1 cells and mouse J774.1 cells with IC50 values of 0.88 and 360 nM, respectively. NTE-122 competively inhibited the ACAT activity in PMA-treated THP-1 cells. NTE-122 also inhibited cellular ACAT activities in PMA-treated THP-1 cells, rat peritoneal macrophages and J774.1 cells with IC50 values of 3.5, 84 and 6800 nM, respectively. Furthermore, NTE-122 prevented cholesterol accumulation in PMA-treated THP-1 cells incubated with acetylated low density lipoprotein, simultaneously with HDL, while it caused accumulation of a significant amount of free cholesterol in the absence and even in the presence of HDL. NTE-122 also enhanced HDL-induced cholesterol efflux from established foam cells converted from PMA-treated THP-1 cells. These results suggest that NTE-122, capable of inhibiting macrophage ACAT activity in humans more strongly than those in the other species, exhibits anti-atherogenic effects by preventing the foam cell formation and enhancing the foam cell regression in humans. (+info)Regulation of Ca2+ transport by sarcoplasmic reticulum Ca2+-ATPase at limiting [Ca2+]. (8/1809)
The factors regulating Ca2+ transport by isolated sarcoplasmic reticulum (SR) vesicles have been studied using the fluorescent indicator Fluo-3 to monitor extravesicular free [Ca2+]. ATP, in the presence of 5 mM oxalate, which clamps intravesicular [Ca2+] at approximately 10 microM, induced a rapid decline in Fluo-3 fluorescence to reach a limiting steady state level. This corresponds to a residual medium [Ca2+] of 100 to 200 nM, and has been defined as [Ca2+]lim, whilst thermodynamic considerations predict a level of less than 1 nM. This value is similar to that measured in intact muscle with Ca2+ fluophores, where it is presumed that sarcoplasmic free [Ca2+] is a balance between pump and leaks. Fluorescence of Fluo-3 at [Ca2+]lim was decreased 70% to 80% by histidine, imidazole and cysteine. The K0.5 value for histidine was 3 mM, suggesting that residual [Ca2+]lim fluorescence is due to Zn2+. The level of Zn2+ in preparations of SR vesicles, measured by atomic absorption, was 0.47+/-0.04 nmol/mg, corresponding to 0.1 mol per mol Ca-ATPase. This is in agreement with findings of Papp et al. (Arch. Biochem. Biophys., 243 (1985) 254-263). Histidine, 20 mM, included in the buffer, gave a corrected value for [Ca2+]lim of 49+/-1.8 nM, which is still higher than predicted on thermodynamic grounds. A possible 'pump/leak' mechanism was tested by the effects of varying active Ca2+ transport 1 to 2 orders with temperature and pH. [Ca2+]lim remained relatively constant under these conditions. Alternate substrates acetyl phosphate and p-NPP gave similar [Ca2+]lim levels even though the latter substrate supported transport 500-fold slower than with ATP. In fact, [Ca2+]lim was lower with 10 mM p-NPP than with 5 mM ATP. The magnitude of passive efflux from Ca-oxalate loaded SR during the steady state of [Ca2+]lim was estimated by the unidirectional flux of 45Ca2+, and directly, following depletion of ATP, by measuring release of 40Ca2+, and was 0.02% of Vmax. Constant infusion of CaCl2 at [Ca2+]lim resulted in a new steady state, in which active transport into SR vesicles balances the infusion rate. Varying infusion rates allows determination of [Ca2+]-dependence of transport in the absence of chelating agents. Parameters of non-linear regression were Vmax=853 nmol/min per mg, K0.5(Ca)=279 nM, and nH(Ca)=1.89. Since conditions employed in this study are similar to those in the sarcoplasm of relaxed muscle, it is suggested that histidine, added to media in studies of intracellular Ca2+ transients, and in the relaxed state, will minimise contribution of Zn2+ to fluophore fluorescence, since it occurs at levels predicted in this study to cause significant overestimation of cytoplasmic free [Ca2+] in the relaxed state. Similar precautions may apply to non-muscle cells as well. This study also suggests that [Ca2+]lim in the resting state is a characteristic feature of Ca2+ pump function, rather than a balance between active transport and passive leakage pathways. (+info)Notable examples include: The production of aniline compounds. General oxidizing agent. Victor Meyer type nucleophilic ... Silver nitrite is an inorganic compound with the formula AgNO2. Silver nitrite has many applications. ... substitution reactions with organobromides or organoiodides forming nitro compounds. Nitroalkene synthesis with nitryl iodide ...
Aniline derivatives are converted to a diazo compounds. In years following the work Baudisch and Cronheim did, Konecny and ...
... bladder cancer in dye workers exposed to aniline compounds; and leukemia and lymphoma in chemical workers exposed to benzene. ...
Aniline 5 is converted to compound 6, in three steps; conversion to an ortho-aminothiol through the Herz-reaction (aniline 5 ... In a last step the nitrile is hydrolysed resulting in 6. This compound is converted to 7 via a ring-closing reaction and ... The compound, (thioindoxyl, 7) is an important intermediate in the organic synthesis of some dyes. Condensation with ... The Herz reaction, named after the chemist Richard Herz, is the chemical conversion of an aniline-derivative (1) to a so-called ...
The three compounds seriously discussed are ethylene, aniline, and dinitrophenol. Even at low levels these organic chemical ... Organic Air Pollutants: This is similar to the general stress hypothesis, but focuses on organic compounds. ... such as acid rain and organic compounds, and drought. Diseases and pests can kill large groups of trees very easily, but the ... compounds have caused: abnormal dropping of foliage, twisted foliage, and killing of seedlings. This is proposed by Fritz Führ ...
Reduction of this nitro compound affords the aniline. Sulfonation with oleum gives 4-amino-5-methoxy-2-methylbenzenesulfonic ... The compound features both amine and methoxy functional groups. It is used as an intermediate in preparation of dyes and ... The compound is obtained in several steps from 4-chlorotoluene. Nitration gives mainly 3-nitro-4-chlorotoluene, which reacts ... para-Cresidine is an organic compound with the formula CH3OC6H3(CH3)NH2. It is a white solid that is soluble in organic ...
The resulting nitro compound is reduced to the aniline. Trimethylaniline is a building block to a variety of bulky ligands. ... Gerald Booth "Nitro Compounds, Aromatic" in "Ullmann's Encyclopedia of Industrial Chemistry" 2007; Wiley-VCH, Weinheim. doi: ... 2,4,6-Trimethylaniline is a organic compound with formula (CH3)3C6H2NH2. It is an aromatic amine that is of commercial interest ... N-heterocyclic carbenes, as found in 2nd generation Grubbs' catalyst, are also prepared from this compound. ...
Most derivatives of aniline are prepared via nitration of aromatic compounds followed by reduction. Nitrations entail combining ... The pure compound is colorless, but older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen ... In elemental analysis by ICP-MS, ICP-AES, GFAA, and Flame AA, dilute nitric acid (0.5 to 5.0%) is used as a matrix compound for ... Nitration of organic compounds with nitric acid is the primary method of synthesis of many common explosives, such as ...
The compound is a derivative of aniline, consisting of an amine bound to two phenyl groups. The compound is a colorless solid, ... T. Kahl, K.-W. Schröder, F. R. Lawrence, W. J. Marshall, Hartmut Höke, Rudolf Jäckh, "Aniline" in Ullmann's Encyclopedia of ... Diphenylamine is manufactured by the thermal deamination of aniline over oxide catalysts: 2 C6H5NH2 → (C6H5)2NH + NH3 It is a ... Diphenylamine is an organic compound with the formula (C6H5)2NH. ... reflecting the antioxidant nature of aniline derivatives. Some ...
Some electron-rich organic compounds (e.g., aniline) also are oxidized at low potentials, but only irreversibly. Oxidation of ... Such organometallic compounds are also known as sandwich compounds. The rapid growth of organometallic chemistry is often ... This compound on boiling under reflux in benzene is converted to ferrocene. Because of the ease of substitution, many ... The strained compounds undergo ring-opening polymerization. Many phosphine derivatives of ferrocenes are known and some are ...
Polymerization of substituted anilines, phenols, and heterocyclic compounds by peroxidase in organic solvents. Columbus, Ohio: ... On the other hand, for an enzyme such as cytochrome c peroxidase, the compounds that donate electrons are very specific, due to ... Other studies have shown that peroxidases may be used successfully to polymerize anilines and phenols in organic solvent ... For example, horseradish peroxidase can use a variety of organic compounds as electron donors and acceptors. Horseradish ...
N,N-Dimethylaniline (DMA) is an organic chemical compound, a substituted derivative of aniline. It consists of a tertiary amine ... DMA is also used as a precursor to other organic compounds. A study of the in vitro metabolism of N,N-dimethylaniline using ... 2007) "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry. John Wiley & Sons: New York. doi:10.1002/14356007.a02_303 ... DMA was first reported in 1850 by the German chemist A. W. Hofmann, who prepared it by heating aniline and iodomethane: C6H5NH2 ...
The compound is obtained by azo coupling of aniline and acetoacetanilide or their derivatives. The class of compounds was ... Arylide yellow, also known as Hansa yellow and monoazo yellow, are a family of organic compounds used as pigments. They are ... and aniline (acetoacetanilide precursor) to produce medium yellows. Pigment Yellow 3 (CAS# 6486-23-3), derived from 4-chloro-2- ...
... is a compound where an aniline molecule is substituted with a bromine atom. Commercially available, this ... "Studies on analgesics of aniline series. I. Preparation and properties of beta-alaninamide series". Chem Pharm Bull. 13: 198- ... compound may be used as a building block, e.g. in the preparation of p-bromobiphenyl via the Gomberg-Bachmann reaction. In the ...
... (1,2-diphenylhydrazine) is an aromatic organic compound consisting of two aniline groups joined via their ...
... is a mild methylating agent, useful for dimethylation of anilines and related heterocyclic compounds. The ... It has some specialized uses in the production of other compounds. Trimethyl phosphate is prepared by treating phosphorus ... Collective Volume, 5, p. 1085 J. Svara, N. Weferling, T. Hofmann "Phosphorus Compounds, Organic" in Ullmann's Encyclopedia of ...
The coupler compounds (couplers) are meta-substituted derivatives of aniline. They come in three major classes based on the ... 2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ... These compounds produce broad-band absorption when they react to form dyes, allowing for more natural-looking hair colors. The ...
The Doebner-Miller reaction is the organic reaction of an aniline with α,β-unsaturated carbonyl compounds to form quinolines. ... Bergström, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... β-unsaturated carbonyl compound is prepared in situ from two carbonyl compounds (via an Aldol condensation), the reaction is ... elimination of one aniline molecule through 8 and rearomatization leads to final product 9. Because α-amino protons are not ...
Electron-rich aromatic compounds, such as phenols, anilines, and various aromatic heterocycles, can be brominated using NBS. ... Side reactions include the formation of α-bromoketones and dibromo compounds. These can be minimized by the use of freshly ... Collective Volume, 6, p. 190 Stotter, P. L.; Hill, K. A. (1973). "α-Halocarbonyl compounds. II. Position-specific preparation ... Collective Volume, 10, p. 128 Djerassi, Carl (1948). "Brominations with N-Bromosuccinimide and Related Compounds. The Wohl- ...
... is a chemical compound which is the amide of salicylic acid and aniline. It is classified as both a salicylamide ...
... s are chemical compounds which consist of an aniline ring substituted with two chlorine atoms and have the ... As aniline derivatives, they are named with the amino group in position 1. They are all colorless, although commercial samples ... Thomas Kahl, Kai-Wilfrid Schröder, F. R. Lawrence, W. J. Marshall, Hartmut Höke, Rudolf Jäckh "Aniline" in Ullmann's ...
... is an organic compound with the formula CH3C(O)CH2C(O)NHC6H5. It is the acetoacetamide derivative of aniline. ... It and many related compounds (prepared from various aniline derivatives) are used in the production of organic pigments called ... Acetoacetanilide is prepared by acetoacetylation of aniline using diketene. To make the dyes, acetoacetanilides are coupled to ...
Aromatic nitriles are often prepared in the laboratory from the aniline via diazonium compounds. This is the Sandmeyer reaction ... Organic compounds containing multiple nitrile groups are known as cyanocarbons. Inorganic compounds containing the −C≡N group ... The first compound of the homolog row of nitriles, the nitrile of formic acid, hydrogen cyanide was first synthesized by C. W. ... A nitrile is any organic compound that has a −C≡N functional group. The prefix cyano- is used interchangeably with the term ...
... (NMA) is an aniline derivative. It is an organic compound with the chemical formula C6H5NH(CH3). The substance ... Chemicals, such as methylal, aniline-type compounds, halogens and those containing phosphorus and silicon, etc. should not ... "Monomethyl aniline". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety ...
The Bechamp reduction is used to reduce aromatic nitro compounds to their corresponding anilines, using iron and hydrochloric ... Tertiary aliphatic nitro compounds, however, are converted in good yield to the amine compound using the Bechamp reduction. Org ... The Bechamp reaction is broadly applicable to aromatic nitro compounds. Aliphatic nitro compounds are more difficult to reduce ... This reaction was originally used to produce large amounts of aniline for industry, but catalytic hydrogenation is the ...
... compound F. Compound F continues to react with the palladium intermediate B, with regeneration of the copper halide, G. ... This coupling can be carried out starting from anilines by formation of the diazonium salt followed by in situ Sonogashira ... The active palladium catalyst is the 14 electron compound Pd0L2, complex A, which reacts with the aryl or vinyl halide in an ... In an inverse Sonogashira coupling the reactants are an aryl or vinyl compound and an alkynyl halide. While a copper co- ...
... and concrete surfaces contaminated with amine compounds (aniline) w... ... Aniline) by DeconGel 1101. AbstractSurface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, ... No comments were found for Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101. Be the first to comment! ... Aniline was chosen as a representative amine compounds (industrial plastics feedstock); DeconGel is expected to have similar ...
benzenetetraamine promotes the reaction [[Plant Extracts results in increased negative regulation of extracellular matrix disassembly] which results in increased negative regulation of cell motility ...
... and the properties of the title compounds are described. Analytical conductometric, spectral (infrared and ultraviolet) and ... Etherate, pyridine, and aniline compounds of the complex tri- and tetra-iodoacids of Zn(II) and Cd(II). ... The existence of metal-nitrogen bond for all pyridine and aniline complexes, except H2CdI4·4An (An=aniline), is adduced from ... The preparation, for the first time, and the properties of the title compounds are described. Analytical conductometric, ...
Title: Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds. ... "Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds". Germany. doi:10.1002/ ... title = {Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds},. author = { ... Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds ...
It is observed in these compounds case as in other LC compounds Vuks isotropic model is favored compared to that of anisotropic ... p-n-alkoxy anilines, 2O.Om with m = 3 to 10 liquid crystalline compounds except with m = 5 which has been already published. ... The rest of the compounds exhibit the nematic LC phase except with m = 10 which shows the smectic-C phase along the nematic ... nO.m and nO.Om compounds play an important role in the fundamental and applied aspects. As a part of our systematic studies of ...
... B. J. Aylett, M. J. Hakim*Journal of the Chemical Society ...
... aniline Precursor products, 3-(Trifluoromethylthio)aniline Downstream products ect. ... Current Page: Home › Chemical Dictionary › 369-68-6 › 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Products ... 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Downstream Products Precursor:. 404-74-0 79576-16-2 370-47-8 90109-81-2 ...
Book; Format: print Publisher: London : Monitoring and Assessment Research Centre, 1986Availability: Items available for loan: WHO HQ [Call number: QV 632 86HE] (1). Withdrawn (1). ...
Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101 Abstract Surface decontamination efficacy determination ... Surface Decontamination of Cadmium Compounds (Cadmium Chloride (CdCl2) and Cadmium Oxide (CdO)) by DeconGel 1101 OBJECTIVE The ... Surface Decontamination of Cyanide Compounds (Potassium Ferricyanide (K3[Fe(CN)6])) by DeconGel 1101 ABSTRACT Surface ... Surface Decontamination of Tin compounds (tributyltin chloride) by DeconGel 1101 Abstract Surface decontamination efficacy of ...
Vilesov, F.I.; Terenin, A.N., The photoionization of the vapors of certain organic compounds, Dokl. Akad. Nauk SSSR, 1957, 115 ... Meek, J.T.; Sekreta, E.; Wilson, W.; Viswanathan, K.S.; Reilly, J.P., The laser photoelectron spectrum of gas phase aniline, J ... Palmer, M.H.; Moyes, W.; Spiers, M.; Ridyard, J.N.A., The electronic structure of substituted benzenes; a study of aniline, the ... Smith, M.A.; Hager, J.W.; Wallace, S.C., Two color photoionization spectroscopy of jet cooled aniline: Vibrational frequencies ...
Aniline Compounds are organic compounds, consisting of a phenyl group attached to an amine group, with a molecular formula ( ... Aniline and substituted Anilines Compounds. "Aniline Compounds (aminobenzenes)" Aniline and substituted Anilines Compounds. In ... Aniline Compounds. In organic chemistry, Aniline Compounds, as organic compounds, consisting of a phenyl group attached to an ... As an aniline compound, Anilides are any aromatic amides obtained by acylation of aniline. Examples of anilide compounds ...
... bladder cancer in dye workers exposed to aniline compounds; leukemia and lymphoma in chemical workers exposed to benzene; ... more quickly after the introduction of new chemical compounds, and in more severe forms. ...
What is the IUPAC name for the compound a. aminobenzene b. benzoamine c. aniline d. no correct response. Organic And Biological ... A chemical bond is formed due to the attraction between the atoms that lead to the formation of a compound or a molecule. ...
Aniline Compounds * Stilbenes * 4-(N-methylamino)-4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene ...
Aniline Compounds / administration & dosage* * Aniline Compounds / adverse effects * Aniline Compounds / pharmacokinetics * ...
0 (AKB-9778); 0 (Angiopoietin-1); 0 (Angiopoietin-2); 0 (Aniline Compounds); 0 (Sulfonic Acids); 0 (Vascular Endothelial Growth ...
0/Aniline Compounds; 0/Ferric Compounds; 0/Manganese Compounds; 0/Polychlorinated Biphenyls; 0/Silicates; 0/Soil; 0/Soil ... Aniline Compounds / chemistry*. Catalysis. Environmental Pollution / prevention & control. Ferric Compounds. Ferritins / ... Manganese Compounds / chemistry. Pentachlorophenol / chemistry*. Polychlorinated Biphenyls / chemistry*. Silicates / chemistry ... The efficiency of the mechanochemical removal was compared with batch experiments for the soluble compounds (PCP and 4-CA). The ...
0 (2-nitroaniline); 0 (Aniline Compounds); 0 (Environmental Pollutants); 0 (Reducing Agents). ... Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative ... In the present work, we demonstrate how this problem can be circumvented by selectively oxidizing offending compounds by ...
Notable examples include: The production of aniline compounds. General oxidizing agent. Victor Meyer type nucleophilic ... Silver nitrite is an inorganic compound with the formula AgNO2. Silver nitrite has many applications. ... substitution reactions with organobromides or organoiodides forming nitro compounds. Nitroalkene synthesis with nitryl iodide ...
Aniline derivatives are converted to a diazo compounds. In years following the work Baudisch and Cronheim did, Konecny and ...
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Aniline Compounds [1]. Anniversaries and Special Events [2]. Anopheles [2]. Antarctic Regions [1]. ...
9.2.2.10.5. 2.2.10.5 Aniline Compounds. 9.2.2.10.6. 2.2.10.6 Azides ...
NIOSH-Author; Carcinogens; Anilines; Chlorine-compounds; Amines; Protein-biochemistry; Oxidative-phosphorylation; Arylamines ...
NIOSH-Author; In-vivo-studies; Laboratory-animals; Anilines; Organo-chlorine-compounds; Chemical-binding; Nucleic-acids; ...
AminesAmidesProduction of anilineBenzeneNitrogenPhenolNitrobenzeneDerivatives of anilineCatalysisAnilidesPhenylamine or aminobenzeneQuaternary ammoniumSynthesisPyridineOrganic compoundColorlessReagentVolatile Organic CAtomsDegradationNitroIUPAC NameChromiumChemicalIntermediatesSaltsMethodsAqueousCarboxylicSubstancesCyclicRedox behaviourChemistryFormulaOxidationPeriodic table ofChlorineInventionBiodegradationInorganic compoundsKetonesLiquidsCarbonHydrocarbonsClass of organicSurface decontaminationColourless
- Aromatic amines such as aniline are, in general, much weaker bases than aliphatic amines. (bionity.com)
- Aniline combines directly with alkyl iodides to form secondary and tertiary amines. (bionity.com)
- Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Biochemi. (chemnet.com)
- The figures below show the boiling and melting point for organic nitrogen compounds as amines, diamines, pyrroles, pyridines, piperidines and quinolines , together with the molecular structures of the different compounds. (engineeringtoolbox.com)
- For the purposes of this study, aniline and other nitrogen compounds not listed among the products specified above are excluded, although they are sometimes considered amines. (prweb.com)
- These are compound amines, bodies of the. (google.com)
- Examples of these compounds include anilines/amines, halogenated aromatics, and ethers. (europa.eu)
- The product's categories are intermediates of dyes and pigments, anilines, amides & amines, anisoles, alkyloxy compounds & phenylacetates and nitro compounds. (lookchem.com)
- Monocyclic aromatic amines bring hazards to human health and aniline is one of them. (thefreedictionary.com)
- As an aniline compound , Anilides are any aromatic amides obtained by acylation of aniline. (wellnessadvocate.com)
- Aniline reacts with carboxylic acids or more readily with acyl chlorides such as acetyl chloride to give amides. (bionity.com)
- The amides formed from aniline are sometimes called anilides , for example CH 3 -CO-NH-C 6 H 5 is acetanilide. (bionity.com)
- Notable examples include: The production of aniline compounds. (wikipedia.org)
- In organic chemistry, Aniline and substituted Anilines Compounds , aka aminobenzenes , are subclass of organic compounds belonging to the benzene and benzene substituted derivatives class in the benzenoid superclass , containing an aminobenzene moiety. (wellnessadvocate.com)
- Benzene, GR ACS is an organic compound that is naturally found in crude oil and when refined is a colorless and highly flammable hydrocarbon. (spectrumchemical.com)
- The existence of metal-nitrogen bond for all pyridine and aniline complexes, except H 2 CdI 4 ·4 An ( An =aniline), is adduced from infrared and far infrared spectral studies. (springer.com)
- Silicon-nitrogen compounds. (growkudos.com)
- Aniline is a slightly pyramidalized molecule, with hybridization of the nitrogen somewhere between sp 3 and sp 2 . (wikipedia.org)
- Ionic compounds include carboxylic acids, sulfonic acids and salts of sulfonic acids, and charged nitrogen compounds (nitrogen with a +5 valence such as quaternary ammonium compounds). (europa.eu)
- A bacterial strain, AN3, which was able to use aniline or acetanilide as sole carbon, nitrogen and energy sources was isolated from activated sludge and identified as Delftia sp. (semanticscholar.org)
- It is flammable by fire and will produce toxic aniline and nitrogen oxide gas by heat. (lookchem.com)
- Aniline can alternatively be prepared from ammonia and phenol derived from the cumene process . (wikipedia.org)
- As an alternative, aniline is also prepared from phenol and ammonia, the phenol being derived from cumene. (bionity.com)
- The reduction of nitrobenzene to aniline was first performed by Nikolay Zinin in 1842, using inorganic sulfide as a reductant ( Zinin reaction ). (wikipedia.org)
- The reduction of nitrobenzene to aniline was also performed as part of reductions by Antoine Béchamp in 1854, using iron as the reductant ( Bechamp reduction ). (wikipedia.org)
- In the second step, the nitrobenzene is hydrogenated, typically at 600 °C in presence of a nickel catalyst to give aniline. (bionity.com)
- Potassium permanganate in neutral solution oxidizes it to nitrobenzene , in alkaline solution to azobenzene, ammonia and oxalic acid, in acid solution to aniline black. (bionity.com)
- Many derivatives of aniline can be prepared in similar fashion. (bionity.com)
- 9 Generally, studies on ferrocene revolve around generation of compounds that are used in materials science, 10 electrochemistry 11,12 catalysis, 13-15 medicinal applications 16-24 and nonlinear optics 25,26 amongst others. (scielo.org.za)
- Only recently, have sp 2 -hybridized phosphorus compounds been utilized as ligands for transition metals in catalysis. (yorku.ca)
- In organic chemistry, Anilides are organic heterocyclic compounds derived from oxoacids RkE(=O)l(OH)m (l not 0) by replacing an OH group by the NHPh group or derivative formed by ring substitution. (wellnessadvocate.com)
- Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. (drugbank.ca)
- Aniline, Reagent, ACS also known as phenylamine or aminobenzene is a toxic organic compound. (spectrumchemical.com)
- The next year was spent in military service at Berlin, but during the summer semester Windaus was able to assist Fischer in a study of the formation of quaternary ammonium compounds from aniline. (encyclopedia.com)
- As a part of our systematic studies of the above homologous series regarding the synthesis, characterization and phase transition studies, here the authors report the polarizabilities and orientational order parameter, S in N-(p-n-ethoxybenzylidene)-p-n-alkoxy anilines, 2O.Om with m = 3 to 10 liquid crystalline compounds except with m = 5 which has been already published. (scirp.org)
- 4-Methoxy-2-nitroaniline is an aniline compound used in the synthesis of dyes and pigments. (alfa.com)
- Also used as an intermediate for the synthesis of dyes, pigments and other chemical compounds. (alfa.com)
- In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. (thefreedictionary.com)
- This review will be focused on the synthesis, in vitro and in vivo studies of hybrid compounds containing 4- and 8-aminoquinoline derivatives. (mdpi.com)
- Numerous nucleophiles could be used by the enzyme as cosubstrates, aniline, pyridine, and 2-mercaptoethanol being the best among compounds tested. (springer.com)
- Aniline is an organic compound with the formula C 6 H 5 NH 2 . (wikipedia.org)
- 1 Introduction Aniline is a liquid organic compound that both toxic and carcinogenic. (witpress.com)
- The simplest organic compound is methane, which contains one carbon atom covalently bonded to four hydrogen atoms. (fishersci.com)
- 11. The method of claim 1 wherein said crosslinking agent includes a low molecular weight organic compound having 2 or more functional groups, at least one functional group being capable of reacting with an unreacted maleic anhydride monomerunit in the centipede polymer and at least one functional group being capable of reacting with the carboxylic acid groups in the maleated polyalkylene. (patentgenius.com)
- Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples. (drugbank.ca)
- It is used as a mild methylating reagent which is used in the dimethylation of aniline and related heterocyclic compound. (alfa.com)
- Ambient air is polluted by many semi-Volatile and Volatile Organic Compounds (SVOCs and VOCs) coming from anthropogenic and natural sources. (environmental-expert.com)
- A chemical bond is formed due to the attraction between the atoms that lead to the formation of a compound or a molecule. (bartleby.com)
- Isomerism is the phenomenon whereby certain compounds, with the same molecular formula, exist in different forms owing to their different organisations of atoms. (etoosindia.com)
- Organic compounds are divided into two main groups: hydrocarbons, which comprise compounds that contain only carbon and hydrogen atoms, and a second type defined by a functional group that has replaced one of the hydrogen atoms in the molecule. (fishersci.com)
- Compounds or allotropes of carbon that contain only carbon atoms are classified as inorganic compounds and exhibit novel properties. (fishersci.com)
- A chemical formula is an easy way of expressing information about the atoms that constitute a particular chemical compound. (statemaster.com)
- Soil column was equipped with the sediments and aquifer media collected from Weihe Riverbed and its bank, and was used to research the characteristics of aniline degradation in the riverbank filtration under sulfate-reducing conditions. (witpress.com)
- The aniline degradation and sulfate reducing produce some intermediates, some of which are harmful to sulfate-reducing microorganisms. (witpress.com)
- However, in deep, anaerobic sediments, aniline degradation is much slower and its half-life is approximately 10 years . (witpress.com)
- At >0.3 mg/L cetyltrimethylammonium bromide (CTAB) negatively impacted degradation of the reference compound aniline. (americanelements.com)
- Degradation of aniline by newly isolated, extremely aniline-tolerant Delftia sp. (semanticscholar.org)
- article{Liu2002DegradationOA, title={Degradation of aniline by newly isolated, extremely aniline-tolerant Delftia sp. (semanticscholar.org)
- A novel and complete gene cluster involved in the degradation of aniline by Delftia sp. (semanticscholar.org)
- Victor Meyer type nucleophilic substitution reactions with organobromides or organoiodides forming nitro compounds. (wikipedia.org)
- The IUPAC name of 3-Amino-4-Chlorobenzotrifluoride is 2-chloro-5-(trifluoromethyl)aniline. (guidechem.com)
- Chromium and its compounds (i.e. (heritageresearch.com)
- Aniline is a volatile aromatic amine used mainly as a chemical feedstock to produce plastics including polyurethane, and used as a rubber additive. (environmental-expert.com)
- By definition, organic compounds contain the element carbon, and exhibit similar chemical properties, which is advantageous from a monitoring perspective. (environmental-expert.com)
- The dyeing of hair is an ancient art that involves treatment of the hair with various chemical compounds. (wikipedia.org)
- Provides comprehensive data for each element of the periodic table of elements including up to 40 properties, names in 10 languages and common chemical compounds. (environmentalchemistry.com)
- Aromatics are organic chemical compounds that are characterized by circular planar conjugated ring structures and are known for their flexible and useful chemical properties. (bccresearch.com)
- IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. (statemaster.com)
- CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. (statemaster.com)
- Compound groups are groups of chemicals that share structural or chemical features. (pharosproject.net)
- Poisonings may be caused by any kind of chemical compounds or liquids for technical used adopted in technique, agriculture and household. (wikiversity.org)
- Chemical antidote is a substance that unites with a poison to form an innocuous chemical compound (unithiol, chelating compounds). (wikiversity.org)
- There are certain compounds capable for neutralization of poison toxicity by chemical binding or functional antagonism. (wikiversity.org)
- At sufficiently high anodic potential, the sulfonated aniline derivatives undergo oxidation processes yielding cation-radical and dimer intermediates, but no polymer deposition was observed on the working electrode surface. (hindawi.com)
- Chromosome-encoded gene cluster for the metabolic pathway that converts aniline to TCA-cycle intermediates in Delftia tsuruhatensis AD9. (semanticscholar.org)
- Chromic acid converts it into quinone, whereas chlorates, in the presence of certain metallic salts (especially of vanadium ), give aniline black. (bionity.com)
- The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. (google.com)
- that their canned peas had been colored with copper salts, and their fruit jams with aniline dyes? (thefreedictionary.com)
- Surface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, aluminum, and concrete surfaces contaminated with amine compounds (aniline) was performed using GC/MS (Gas Chromatography/Mass Spectrometry) according to Environmental Protection Agency (EPA) SW-846 Methods: 3500C (Sampling) and 8270C (Analysis). (environmental-expert.com)
- Optimized experimental and analytical methods were successfully developed following standardized EPA sampling and analysis methods as guidelines for determination of organic compounds dissolved in a suitable solvent able to completely solvate aniline as well as DeconGel components. (environmental-expert.com)
- Methods to predict the hydrolysis rates of organic compounds for use in the environmental assessment of pollutants have not advanced significantly since the early 80s of the 20th century. (europa.eu)
- To develop such predictive methods, one needs a set of rate constants for a series of compounds that have systematic variations in structure and a database of molecular descriptors related to the substituents on the reactant molecule. (europa.eu)
- Ketoamine compounds and related methods for reactivation of tumor suppressor protein p53. (sumobrain.com)
- This invention relates to aniline derived non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of suc. (sumobrain.com)
- Laboratory experience to complement Organic Chemistry I. Techniques explored include methods for separation, purification and identification of organic compounds, and syntheses. (uwosh.edu)
- Crystallise the aniline from aqueous EtOH. (chemicalbook.com)
- The oligomers are prepared by reacting tetraamines, diaminodiols, or diaminothiols (i.e. four-functional compounds) with poly-carboxylic acid halides, and crosslinking phenylimide end cap monomers in a suitable solvent under an inert atmosphere. (google.es)
- NHFG compounds are those that do not have any heteroatoms that can undergo hydrolysis over the pH range of 5 to 9 at 25 °C. Examples include xylenes, carboxylic acids, and polycyclic aromatic hydrocarbons (PAHs), 2. (europa.eu)
- This compound group is defined by the SMILES string '[Rh]' and subsequently filtered to remove substances containing '[C]'. For more information on SMILES, see https://en.wikipedia.org/wiki/Simplified_molecular-input_line-entry_system . (pharosproject.net)
- and although he was mainly concerned with the structure of cholesterol, he investigated many other sterols and established the membership of these substances in a group that he called the "sterines," In 1908 Windaus found that cholesterol formed an insoluble compound with digitonin. (encyclopedia.com)
- and among the derivatives of these substances he had prepared a compound that he called cholanic acid. (encyclopedia.com)
- The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation. (freepatentsonline.com)
- Experimental results showed that both aniline derivatives are electroactive compounds exhibiting redox behaviour in the range of potential of −0.2 V-1.6 V. Due to the self-doping effect induced by sulfonic groups, AnPS and DAnPS compounds have good electroactivity even in neat water solution. (hindawi.com)
- Electrochemical studies on these compounds reveal that redox behaviour of the iron centre is influenced by the position imine or amine groups. (scielo.org.za)
- In organic chemistry, Aniline Compounds , as organic compounds , consisting of a phenyl group attached to an amine group, with a molecular formula (C 6 H 5 NH 2 ). (wellnessadvocate.com)
- I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
- He was particularly struck by the physiological applications of Fischer's work and began to develop what later became the basis for his approach to chemistry, an interest in the general physiological mechanisms of the compounds he studied. (encyclopedia.com)
- The molecular formula of the compounds is given below. (scirp.org)
- Silver nitrite is an inorganic compound with the formula AgNO2. (wikipedia.org)
- The compounds of formula 1 inhibit the tyrosine kinase activity of vekstftdctorreseptorer such herein, HER2 and HER4 thereby making them useful as antiproliferative agents. (google.com)
- The compounds of formula 1 are also useful for treating other diseases associated with signal transduction pathways operating through vekstfakiorreseptorer. (google.com)
- A tetrakisazo compound represented by the following formula (1) in the free acid form: ##STR1## wherein Q1 and Q2 independently represent phenylene or naphthylene group which may be optionally substituted, R4, R5 and R6 independently represent a hydrogen atom, a halogen atom, a hydroxy group, a sulfonic. (google.com)
- 5. A tetrakisazo compound represented by the following formula (5) in the free acid form: ##STR27## or a salt thereof. (google.com)
- The compounds have the general formula (Y1)m-Ar1(X1)-C(=O)Var2(X2)-(Y2)p (I), wherein V de. (sumobrain.com)
- A new condensed polycyclic compound represented by general formula [I]: wherein R¿1? (sumobrain.com)
- A fluorene compound represented by the following general formula [I]: is used to provide an organic luminescent device. (sumobrain.com)
- The oxidation of aniline has been carefully investigated. (bionity.com)
- An EC mechanism for electrooxidation of N- substituted anilines based by in situ UV-Vis spectroelectroscopy had been proposed [ 5 - 8 ], and based on this mechanism it had been reported that the formation of primary radical cation is the rate-limiting step in electrochemical oxidation of aniline. (hindawi.com)
- In fact, the majority of elements in the periodic table of elements are inorganic compounds. (fishersci.com)
- The desired compound has a chlorine in the meta position. (coursehero.com)
- For comprehensive list see Hunt ress, Organic Chlorine Compounds (New York, 1948). (sciencemadness.org)
- Huntress, Organic Chlorine Compounds (New York, 1948). (sciencemadness.org)
- The present invention relates to a tetrakisazo compound and its use, and particularly to an ink for an ink-jet printer containing the compound. (google.com)
- The invention is directed to a bi-aryl compound having a unique immunomodulating activity, a process for a preparation thereof, a pharmaceutical composition containing the same, and a method of preventing or treating disorders or disease. (sumobrain.com)
- The present invention provides a combinatorial approach to a library of novel compounds having four diversity points. (sumobrain.com)
- The invention relates to the production of fluorine-containing anilines. (sumobrain.com)
- Biodegradation of aniline in an alkaline environment by a novel strain of the halophilic bacterium, Dietzia natronolimnaea JQ-AN. (semanticscholar.org)
- However it is unable to react with inorganic compounds. (wikiversity.org)
- Monomethyl and dimethyl aniline are colourless liquids prepared by heating aniline, aniline hydro-chloride and methyl alcohol in an autoclave at 220 °C. They are of great importance in the colour industry. (bionity.com)
- It is therefore essential to determine appropriate concentrations of mitigating sorbents to render a Headspace Test based on carbon analysis suitable to determine ready biodegradability of compounds which might inhibit inoculum. (americanelements.com)
- Organic compounds are, at the most basic level, compounds that contain carbon and hydrogen. (fishersci.com)
- Because of the almost infinite number of ways in which carbon can bond with carbon and other elements, it's no surprise that about 95 percent of the millions of known compounds are organics with highly diverse structures. (fishersci.com)
- This analogy is based upon the fact that phosphorus and carbon exhibit almost similar electron acceptor and electron donor abilities allowing such phosphorus compounds to be utilized instead of genuine carbon species. (yorku.ca)
- The main components of fossil fuels (petroleum and natural gas) are a class of organic compounds known as hydrocarbons. (fishersci.com)
- Anilino Naphthalenesulfonates are an aniline compound class of organic naphthalenesulfonate compounds , which contain an anilino (phenylamino) group linked to a salt or ester of naphthalenesulfonic acid. (wellnessadvocate.com)
- Excellent surface decontamination was achieved by applying DeconGel 1101 onto surfaces contaminated with amine compounds (Aniline) resulting in encapsulation of contaminants by DeconGel's active components. (environmental-expert.com)
- Elements & Compounds) a colourless oily pungent poisonous liquid used in the manufacture of dyes, plastics, pharmaceuticals, and explosives. (thefreedictionary.com)