Aniline CompoundsAniline Hydroxylase: A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.Aniline Mustard: Alkylating anti-neoplastic agent.ToluidinesAminophenols: Phenols substituted in any position by an amino group.Aminopyrine N-DemethylaseBiodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Delftia: A genus of gram-negative, strictly aerobic chemoorganotrophic bacteria, in the family COMAMONADACEAE.Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)Azo CompoundsHexobarbital: A barbiturate that is effective as a hypnotic and sedative.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Delftia acidovorans: A species of gram-negative rod-shaped bacteria found ubiquitously and formerly called Comamonas acidovorans and Pseudomonas acidovorans. It is the type species of the genus DELFTIA.Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.Propanil: A chlorinated anilide that is used as an herbicide.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.Ethylmorphine: A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.IminesPalladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Water Pollutants: Substances or organisms which pollute the water or bodies of water. Use for water pollutants in general or those for which there is no specific heading.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Oxidative Coupling: The reaction of two molecular entities via oxidation usually catalyzed by a transition metal compound and involving dioxygen as the oxidant.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Kinetics: The rate dynamics in chemical or physical systems.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Acetone: A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.o-Aminoazotoluene: An azo dye with carcinogenic properties.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Quinacrine Mustard: Nitrogen mustard analog of quinacrine used primarily as a stain in the studies of chromosomes and chromatin. Fluoresces by reaction with nucleic acids in chromosomes.

Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes. (1/1809)

1. The time courses of Ca2+ current and Ca2+ spark occurrence were determined in single rat ventricular myocytes voltage clamped with patch pipettes containing 0.1 microM fluo-3. Acquisition of line-scan images on a laser scanning confocal microscope was synchronized with measurement of Cd2+-sensitive Ca2+ currents. In most cells, individual Ca2+ sparks were observed by reducing Ca2+ current density with nifedipine (0.1-8 microM). 2. Ca2+ sparks elicited by depolarizing voltage-clamp pulses had a peak [Ca2+] amplitude of 289 +/- 3 nM with a decay half-time of 20.8 +/- 0.2 ms and a full width at half-maximum of 1.40 +/- 0.03 microm (mean +/- s. e.m., n = 345), independent of the membrane potential. 3. The time between the beginning of a depolarization and the initiation of each Ca2+ spark was calculated and data were pooled to construct waiting time histograms. Exponential functions were fitted to these histograms and to the decaying phase of the Ca2+ current. This analysis showed that the time constants describing Ca2+ current and Ca2+ spark occurrence at membrane potentials between -30 mV and +30 mV were not significantly different. At +50 mV, in the absence of nifedipine, the time constant describing Ca2+ spark occurrence was significantly larger than the time constant of the Ca2+ current. 4. A simple model is developed using Poisson statistics to relate macroscopic Ca2+ current to the opening of single L-type Ca2+ channels at the dyad junction and to the time course of Ca2+ spark occurrence. The model suggests that the time courses of macroscopic Ca2+ current and Ca2+ spark occurrence should be closely related when opening of a single L-type Ca2+ channel initiates a Ca2+ spark. By comparison with the data, the model suggests that Ca2+ sparks are initiated by the opening of a single L-type Ca2+ channel at all membrane potentials encountered during an action potential.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/1809)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/1809)

Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia.  (+info)

Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. (4/1809)

Myeloperoxidase is the most abundant protein in neutrophils and catalyzes the production of hypochlorous acid. This potent oxidant plays a central role in microbial killing and inflammatory tissue damage. 4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation. We have investigated the mechanism by which benzoic acid hydrazides (BAH) are oxidized by myeloperoxidase, and we have determined the features that enable them to inactivate the enzyme. BAHs readily reduced compound I of myeloperoxidase. The rate constants for these reactions ranged from 1 to 3 x 10(6) M-1 s-1 (15 degrees C, pH 7.0) and were relatively insensitive to the substituents on the aromatic ring. Rate constants for reduction of compound II varied between 6.5 x 10(5) M-1 s-1 for ABAH and 1.3 x 10(3) M-1 s-1 for 4-nitrobenzoic acid hydrazide (15 degrees C, pH 7.0). Reduction of both compound I and compound II by BAHs adhered to the Hammett rule, and there were significant correlations with Brown-Okamoto substituent constants. This indicates that the rates of these reactions were simply determined by the ease of oxidation of the substrates and that the incipient free radical carried a positive charge. ABAH was oxidized by myeloperoxidase without added hydrogen peroxide because it underwent auto-oxidation. Although BAHs generally reacted rapidly with compound II, they should be poor peroxidase substrates because the free radicals formed during peroxidation converted myeloperoxidase to compound III. We found that the reduction of ferric myeloperoxidase by BAH radicals was strongly influenced by Hansch's hydrophobicity constants. BAHs containing more hydrophilic substituents were more effective at converting the enzyme to compound III. This implies that BAH radicals must hydrogen bond to residues in the distal heme pocket before they can reduce the ferric enzyme. Inactivation of myeloperoxidase by BAHs was related to how readily they were oxidized, but there was no correlation with their rate constants for reduction of compounds I or II. We propose that BAHs destroy the heme prosthetic groups of the enzyme by reducing a ferrous myeloperoxidase-hydrogen peroxide complex.  (+info)

A comparison of electron-capture GLC, electrolytic-conductivity GLC and UV-absorption HPLC for the analysis of some herbicides in foods. (5/1809)

A comparison of gas chromatography with electron-capture or electrolytic-conductivity (nitrogen mode) detection, and high-pressure liquid chromatography (HPLC) with UV-absorption detection (254 nm) was carried out for the analysis of several herbicides in foods. Linuron, propanil, terbacil, benzoylprop-ethyl, and the fungicide DCNA in samples of cabbage, corn, potato, and wheat spiked at 2 and 0.2 ppm were examined. The pesticides were extracted with acetone, partitioned into petroleum ether-methylene chloride, and cleaned up on a 2% deactivated Florisil column before direct chromatographic analysis. Electron-capture gas-liquid chromatography (GLC) was most suitable for DCNA and benzoylprop-ethyl while UV-absorption HPLC was best for terbacil analysis. Linuron and propanil gave similar results for both electron-capture GLC and HPLC. Electrolytic-conductivity GLC could detect all pesticides at the 0.2 ppm level and exhibited the least number of extraneous peaks in the chromatograms.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (6/1809)

We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. (7/1809)

We investigated the effects of a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl)ureido]methyl]cyclohexane), on ACAT activities in macrophages originating from several species and high-density lipoprotein (HDL)-induced cholesterol efflux in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells. NTE-122 inhibited cell-free ACAT activities in human PMA-treated THP-1 cells and mouse J774.1 cells with IC50 values of 0.88 and 360 nM, respectively. NTE-122 competively inhibited the ACAT activity in PMA-treated THP-1 cells. NTE-122 also inhibited cellular ACAT activities in PMA-treated THP-1 cells, rat peritoneal macrophages and J774.1 cells with IC50 values of 3.5, 84 and 6800 nM, respectively. Furthermore, NTE-122 prevented cholesterol accumulation in PMA-treated THP-1 cells incubated with acetylated low density lipoprotein, simultaneously with HDL, while it caused accumulation of a significant amount of free cholesterol in the absence and even in the presence of HDL. NTE-122 also enhanced HDL-induced cholesterol efflux from established foam cells converted from PMA-treated THP-1 cells. These results suggest that NTE-122, capable of inhibiting macrophage ACAT activity in humans more strongly than those in the other species, exhibits anti-atherogenic effects by preventing the foam cell formation and enhancing the foam cell regression in humans.  (+info)

Regulation of Ca2+ transport by sarcoplasmic reticulum Ca2+-ATPase at limiting [Ca2+]. (8/1809)

The factors regulating Ca2+ transport by isolated sarcoplasmic reticulum (SR) vesicles have been studied using the fluorescent indicator Fluo-3 to monitor extravesicular free [Ca2+]. ATP, in the presence of 5 mM oxalate, which clamps intravesicular [Ca2+] at approximately 10 microM, induced a rapid decline in Fluo-3 fluorescence to reach a limiting steady state level. This corresponds to a residual medium [Ca2+] of 100 to 200 nM, and has been defined as [Ca2+]lim, whilst thermodynamic considerations predict a level of less than 1 nM. This value is similar to that measured in intact muscle with Ca2+ fluophores, where it is presumed that sarcoplasmic free [Ca2+] is a balance between pump and leaks. Fluorescence of Fluo-3 at [Ca2+]lim was decreased 70% to 80% by histidine, imidazole and cysteine. The K0.5 value for histidine was 3 mM, suggesting that residual [Ca2+]lim fluorescence is due to Zn2+. The level of Zn2+ in preparations of SR vesicles, measured by atomic absorption, was 0.47+/-0.04 nmol/mg, corresponding to 0.1 mol per mol Ca-ATPase. This is in agreement with findings of Papp et al. (Arch. Biochem. Biophys., 243 (1985) 254-263). Histidine, 20 mM, included in the buffer, gave a corrected value for [Ca2+]lim of 49+/-1.8 nM, which is still higher than predicted on thermodynamic grounds. A possible 'pump/leak' mechanism was tested by the effects of varying active Ca2+ transport 1 to 2 orders with temperature and pH. [Ca2+]lim remained relatively constant under these conditions. Alternate substrates acetyl phosphate and p-NPP gave similar [Ca2+]lim levels even though the latter substrate supported transport 500-fold slower than with ATP. In fact, [Ca2+]lim was lower with 10 mM p-NPP than with 5 mM ATP. The magnitude of passive efflux from Ca-oxalate loaded SR during the steady state of [Ca2+]lim was estimated by the unidirectional flux of 45Ca2+, and directly, following depletion of ATP, by measuring release of 40Ca2+, and was 0.02% of Vmax. Constant infusion of CaCl2 at [Ca2+]lim resulted in a new steady state, in which active transport into SR vesicles balances the infusion rate. Varying infusion rates allows determination of [Ca2+]-dependence of transport in the absence of chelating agents. Parameters of non-linear regression were Vmax=853 nmol/min per mg, K0.5(Ca)=279 nM, and nH(Ca)=1.89. Since conditions employed in this study are similar to those in the sarcoplasm of relaxed muscle, it is suggested that histidine, added to media in studies of intracellular Ca2+ transients, and in the relaxed state, will minimise contribution of Zn2+ to fluophore fluorescence, since it occurs at levels predicted in this study to cause significant overestimation of cytoplasmic free [Ca2+] in the relaxed state. Similar precautions may apply to non-muscle cells as well. This study also suggests that [Ca2+]lim in the resting state is a characteristic feature of Ca2+ pump function, rather than a balance between active transport and passive leakage pathways.  (+info)

*Azobenzene reductase

The systematic name of this enzyme class is N,N-dimethyl-1,4-phenylenediamine, aniline:NADP+ oxidoreductase. Other names in ... This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with ... H to reduce one equivalent of the azo compound substrate (for example methyl red where Ar = p-dimethylaniline and Ar' = o- ... benzoic acid) into two equivalents of aniline product: Ar-N=N-Ar' + 2(NAD(P)H + H+) ⇌ {\displaystyle \rightleftharpoons } Ar- ...

*Silver nitrite

Notable examples include: The production of aniline compounds. General oxidizing agent. Victor Meyer type nucleophilic ... Silver nitrite is an inorganic compound with the formula AgNO2. Silver nitrite has many applications. ... substitution reactions with organobromides or organoiodides forming nitro compounds. Nitroalkene synthesis with nitryl iodide ...

*Cancer cluster

... bladder cancer in dye workers exposed to aniline compounds; and leukemia and lymphoma in chemical workers exposed to benzene. ...

*Para-Cresidine

Reduction of this nitro compound affords the aniline. Sulfonation with oleum gives 4-amino-5-methoxy-2-methylbenzenesulfonic ... The compound features both amine and methoxy functional groups. It is used as an intermediate in preparation of dyes and ... The compound is obtained in several steps from 4-chlorotoluene. Nitration gives mainly 3-nitro-4-chlorotoluene, which reacts ... para-Cresidine is an organic compound with the formula CH3OC6H3(CH3)NH2. It is a white solid that is soluble in organic ...

*3-(Trifluoromethyl)aniline

... aniline is a compound with the molecular formula CF3C6H4NH2. It is an aromatic amine. 3-(Trifluoromethyl)aniline is used in the ... 3-(Trifluoromethyl)aniline is then converted to the urea, fluometuron. Flufenamic acid Morniflumate Ufenamate Flubanilate ... Salfluverine Colfenamate Siegemund, Günter "Aromatic Compounds with Fluorinated Side-Chains" in Ullmann's Encyclopedia of ...

*N-Methylaniline

... (NMA) is an aniline derivative. It is an organic compound with the chemical formula C6H5NH(CH3). The substance ... Chemicals, such as methylal, aniline-type compounds, halogens and those containing phosphorus and silicon, etc. should not ... "Monomethyl aniline". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety ...

*Povarov reaction

The imine in this organic reaction is a condensation reaction product from an aniline type compound and a benzaldehyde type ... Treatment of these compounds with TBAF invokes a ring-expansion that provides the corresponding benzazepines. One variation of ... The reaction mechanism for the Povarov reaction to the quinoline is outlined in scheme 1. In step one aniline and benzaldehyde ... Scheme 4 depicts this 4 component reaction with the ethyl ester of glyoxylic acid, 3,4-dihydro-2H-pyran, aniline and ethanol ...

*Aniline

... is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is ... In commerce, three brands of aniline are distinguished: aniline oil for blue, which is pure aniline; aniline oil for red, a ... Aniline is a weak base. Aromatic amines such as aniline are, in general, much weaker bases than aliphatic amines. Aniline ... The chemistry of aniline is rich because the compound has been cheaply available for many years. Below are some classes of its ...

*Red 2G

... can be converted to the toxic compound aniline, so there are concerns Red 2G may ultimately interfere with blood ... In July 2007 the EFSA established E128 is potentially carcinogenic as it forms aniline in the body when consumed. The pressure ...

*Herz reaction

Aniline 5 is converted to compound 6, in three steps; conversion to an ortho-aminothiol through the Herz-reaction (aniline 5 ... In a last step the nitrile is hydrolysed resulting in 6. This compound is converted to 7 via a ring-closing reaction and ... The compound, (thioindoxyl, 7) is an important intermediate in the organic synthesis of some dyes. Condensation with ... The Herz reaction, named after the chemist Richard Herz, is the chemical conversion of an aniline-derivative (1) to a so-called ...

*4-Bromoaniline

... is a compound where an aniline molecule is substituted with a bromine atom. Commercially available, this ... "Studies on analgesics of aniline series. I. Preparation and properties of beta-alaninamide series". Chem Pharm Bull. 13: 198- ... compound may be used as a building block, e.g. in the preparation of p-bromobiphenyl via the Gomberg-Bachmann reaction. In the ...

*2,4,6-Trimethylaniline

The resulting nitro compound is reduced to the aniline. Trimethylaniline is a building block to a variety of bulky ligands. ... Gerald Booth "Nitro Compounds, Aromatic" in "Ullmann's Encyclopedia of Industrial Chemistry" 2007; Wiley-VCH, Weinheim. doi: ... 2,4,6-Trimethylaniline is a organic compound with formula (CH3)3C6H2NH2. It is an aromatic amine that is of commercial interest ... N-heterocyclic carbenes, as found in 2nd generation Grubbs' catalyst, are also prepared from this compound. ...

*Nitrile

Aromatic nitriles are often prepared in the laboratory from the aniline via diazonium compounds. This is the Sandmeyer reaction ... Organic compounds containing multiple nitrile groups are known as cyanocarbons. Inorganic compounds containing the −C≡N group ... The first compound of the homolog row of nitriles, the nitrile of formic acid, hydrogen cyanide was first synthesized by C. W. ... A nitrile is any organic compound that has a −C≡N functional group. The prefix cyano- is used interchangeably with the term ...

*Aniline (data page)

Aniline absorbs in the K (220 - 250 nm) and the B (250 - 290 nm) bands exhibited by benzenoid compounds. The K and B bands ... See also: m-xylene (data page) p-xylene (data page) Aniline is a benzenoid compound. The NH2 group attached to the benzene ring ... When dissolved in ethanol, λmax for aniline is 230 nm, but in dilute aqueous acid λmax is 203 nm. In the latter case the ... This page provides supplementary chemical data on aniline. The handling of this chemical may incur notable safety precautions. ...

*Forest dieback

The three compounds seriously discussed are ethylene, aniline, and dinitrophenol. Even at low levels these organic chemical ... Organic Air Pollutants: This is similar to the general stress hypothesis, but focuses on organic compounds. ... such as acid rain and organic compounds, and drought. Diseases and pests can kill large groups of trees very easily, but the ... compounds have caused: abnormal dropping of foliage, twisted foliage, and killing of seedlings. This is proposed by Fritz Führ ...

*Baudisch reaction

Aniline derivatives are converted to a diazo compounds. In years following the work Baudisch and Cronheim did, Konecny and ...

*Trimethyl phosphate

... is a mild methylating agent, useful for dimethylation of anilines and related heterocyclic compounds. The ... It has some specialized uses in the production of other compounds. Trimethyl phosphate is prepared by treating phosphorus ... Collective Volume, 5, p. 1085 J. Svara, N. Weferling, T. Hofmann "Phosphorus Compounds, Organic" in Ullmann's Encyclopedia of ...

*Ferrocene

Some electron-rich organic compounds (e.g., aniline) also are oxidized at low potentials, but only irreversibly. Oxidation of ... Such organometallic compounds are also known as sandwich compounds. The rapid growth of organometallic chemistry is often ... This compound on boiling under reflux in benzene is converted to ferrocene. Because of the ease of substitution, many ... The strained compounds undergo ring-opening polymerization. Many phosphine derivatives of ferrocenes are known and some are ...

*Peroxidase

Polymerization of substituted anilines, phenols, and heterocyclic compounds by peroxidase in organic solvents. Columbus, Ohio: ... On the other hand, for an enzyme such as cytochrome c peroxidase, the compounds that donate electrons are very specific, due to ... Other studies have shown that peroxidases may be used successfully to polymerize anilines and phenols in organic solvent ... For example, horseradish peroxidase can use a variety of organic compounds as electron donors and acceptors. Horseradish ...

*N-Ethyl-N-(2-chloroethyl)aniline

... is the organic compound with the formula C6H5N(Et)(CH2CH2Cl) (Et = ethyl). It is a low-melting ... The compound is a precursor to several cationic azo dyes via reaction of the chloroethyl group with tertiary amines or pyridine ...

*Hydrazobenzene

... (1,2-diphenylhydrazine) is an aromatic organic compound consisting of two aniline groups joined via their ...

*Diphenylamine

The compound is a derivative of aniline, consisting of an amine bound to two phenyl groups. The compound is a colorless solid, ... T. Kahl, K.-W. Schröder, F. R. Lawrence, W. J. Marshall, Hartmut Höke, Rudolf Jäckh, "Aniline" in Ullmann's Encyclopedia of ... Diphenylamine is manufactured by the thermal deamination of aniline over oxide catalysts: 2 C6H5NH2 → (C6H5)2NH + NH3 It is a ... Diphenylamine is an organic compound with the formula (C6H5)2NH. ... reflecting the antioxidant nature of aniline derivatives. Some ...

*Dimethylaniline

N,N-Dimethylaniline (DMA) is an organic chemical compound, a substituted derivative of aniline. It consists of a tertiary amine ... DMA is also used as a precursor to other organic compounds. A study of the in vitro metabolism of N,N-dimethylaniline using ... 2007) "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry. John Wiley & Sons: New York. doi:10.1002/14356007.a02_303 ... DMA was first reported in 1850 by the German chemist A. W. Hofmann, who prepared it by heating aniline and iodomethane: C6H5NH2 ...

*Aromatic amine

It is a broad class of compounds that encompasses anilines, but also many more complex aromatic rings and many amine ... Such compounds occur widely. Aromatic amines are widely used as precursor to pesticides, pharmaceuticals, and dyes. Since ... An aromatic amine is an organic compound consisting of an aromatic ring attached to an amine. ...

*Bechamp reduction

The Bechamp reduction is used to reduce aromatic nitro compounds to their corresponding anilines, using iron and hydrochloric ... Tertiary aliphatic nitro compounds, however, are converted in good yield to the amine compound using the Bechamp reduction. Org ... The Bechamp reaction is broadly applicable to aromatic nitro compounds. Aliphatic nitro compounds are more difficult to reduce ... This reaction was originally used to produce large amounts of aniline for industry, but catalytic hydrogenation is the ...

*Nikolai Menshutkin

Between 1889 and 1895 Menshutkin focused on amines, on the kinetics of their interaction with alkyl halogen compounds and its ... rate of chemical change was studied in the case of the formation of amides and anilides by the action of ammonia and aniline on ... March 1866 against Aleksandr Butlerov and Dmitri Mendeleev and in autumn began teaching a course on organic nitrogen compounds ...

*Nitric acid

Most derivatives of aniline are prepared via nitration of aromatic compounds followed by reduction. Nitrations entail combining ... The pure compound is colorless, but older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen ... In elemental analysis by ICP-MS, ICP-AES, GFAA, and Flame AA, dilute nitric acid (0.5 to 5.0%) is used as a matrix compound for ... Nitration of organic compounds with nitric acid is the primary method of synthesis of many common explosives, such as ...
Ly et al: CAA Predisposes to rt-PA Related Hhemorrhage Cerebral b-Amyloid Detected by Pittsburgh Compound B Positron Emission Topography Predisposes to Recombinant Tissue Plasminogen Activator-Related Hemorrhage John V. Ly,1 Christopher C. Rowe,2 Victor L. Villemagne,2 Jorge A. Zavala,1 Henry Ma,1 Graeme OKeefe,2 Sylvia J. Gong,2 Rico Gunawan,1 Leonid Churilov,1 Tim Saunder,2 Uwe Ackerman,2 Henri Tochon-Danguy,2 and Geoffrey A. Donnan1,3 Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral b-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, ...
Name: 2,6-Dichioro-4-nitroaniline CA Name: Benzenamine,2,6-dichloro-4-nitro- Molecular Structure: 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 Molecular Formula:C6H4Cl2N2O2 Molecular Weight: 207.00 CAS Registry Number: 99-30-9
5-chloro-2-methyl-4-nitroaniline chemical properties, What are the chemical properties of 5-chloro-2-methyl-4-nitroaniline 13852-51-2, What are the physical properties of 5-chloro-2-methyl-4-nitroaniline ect.
3-Methyl-4-nitroaniline chemical properties, What are the chemical properties of 3-Methyl-4-nitroaniline 611-05-2, What are the physical properties of 3-Methyl-4-nitroaniline ect.
2-Bromo-5-nitroaniline, 98%, ACROS Organics™ 25g; Glass bottle 2-Bromo-5-nitroaniline, 98%, ACROS Organics™ Bromomethylphenyl to Bromophenyla -Organics
This from OBrien and McCully, THE STUDY OF PLANT STRUCTURE: PRINCIPLES AND SELECTED METHODS (1981): 0.05%w/v water soluble aniline blue, CI No. 42755 (source: Polysciences Co.) in phospahte buffer, pH 8.5. Use freshly made solution or store in dark bottle in refrig. Discard when blue color changes to greenish. This is a flurochrome. Absorbance maximum is ca. 370 nm, peak emission is 509 nm (exciter BG12 combined with barrier 53 or barrrier 65 + 50 which will minimize chlorophyll autofluorescence). Dont know the original reference, but maybe this will do the trick. At 11:40 AM 6/26/98 -0700, you wrote: ,Would someone please post the recipe for the aniline blue stain used to ,stain pollen tubes in situ derived from Kho and Baer? Our library does not ,carry Euphytica, where it was published, and interlibrary loan has taken a ,month and still not come up with the paper. , ,Thanks. ,Peggy E. Pollak ,Department of Biological Sciences ,Northern Arizona University ,Flagstaff, AZ 86011-5640 , , , , ...
HPS Rathore.; SK Tiwari. Spectrophotometric determination of nitrite in polluted waters using 3-nitroaniline. Analytica chimica acta. 1991 242, (1) , 225-228.. AS Yazdi, F Mofazzeli, Z Eshaghi. Determination of 3-nitroaniline in water samples by directly suspended droplet three-phase liquid-phase microextraction using 18-crown-6 ether and high-performance liquid chromatography. Journal of Chromatography A. 2009 1216, (26) , 5086-5091.. ...
[150 Pages Report] Check for Discount on 2016 Global and Chinese 2-Methyl-4-Nitroaniline Industry Market Research Report report by Prof Research. The Global and Chinese 2-Methyl-4-Nitroaniline Industry, 2011-...
Unscramble aniline, Unscramble letters aniline, Point value for aniline, Word Decoder for aniline, Word generator using the letters aniline, Word Solver aniline, Possible Scrabble words with aniline, Anagram of aniline
Aniline dioxygenase is a multicomponent Rieske nonheme-iron dioxygenase enzyme isolated from Acinetobacter sp. strain YAA. Saturation mutagenesis of the substrate-binding pocket residues, which were identified using a homology model of the α subunit of the terminal dioxygenase (AtdA3), was used to probe the molecular determinants of AtdA substrate specificity. The V205A mutation widened the substrate specificity of aniline dioxygenase to include 2-isopropylaniline, for which the wild-type enzyme has no activity. The V205A mutation also made 2-isopropylaniline a better substrate for the enzyme than 2,4-dimethylaniline, a native substrate of the wild-type enzyme. The I248L mutation improved the activity of aniline dioxygenase against aniline and 2,4-dimethylaniline approximately 1.7-fold and 2.1-fold, respectively. Thus, it is shown that the α subunit of the terminal dioxygenase indeed plays a part in the substrate specificity as well as the activity of aniline dioxygenase. Interestingly, the ...
Creative-Proteomics offer cas 99-30-9 2,6-DICHLORO-4-NITROANILINE (RING-13C6, 99%) (DICHLORAN). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Polymeric compositions are disclosed comprising protonated, electrically conducting polyaniline; cyclic organic compounds capable of forming ring-ring interactions with the six-membered rings of the polyaniline and hydrogen bonding with the NH groups of the polyaniline; and anionic surface active additives. According to the invention, no particular requirements are posed for the counter-ions of polyaniline, which allows for the use of non-functionilized counter-ions. The conducting polyaniline complexes of the invention are processible in the fluid-phase and exhibit significantly improved electrical properties.
CH421 Experiment 2 Nitration of Aniline: a three-step protecting group strategy to prepare p-nitroaniline Reading: Organic Chemistry by John McMurry, 8e, Chapter Techniques: recrystallization,
Environmental pollution is always the hottest topic in public conversation and one of the most concerned aspects of human health. The thin film sputtered microelectrode devices have been developed to improve the quality of human health, by offering better monitoring capabilities. This thesis is divided into three parts and the studies were performed on chemical sensor technology currently available and under development using modified methods. In the first part of this thesis: (i) the studies are related to synthesis, characterization and polymerisation of polyaniline (PANI) and polyaniline-co-poly(2,2´-dithiodianline) (PANI-co-PDTDA). Polyaniline (PANI) and the copolymer of aniline with dithiodianiline, an aniline derivative containing S-S-links were of interest in polymer synthesis. Electrochemical synthesis was carried out in 1 M HCl and different concentrations of H2SO4 (1, 2.5, and 5 M) solutions for PANI and PANI-co-PDTDA respectively. The PANI and PANI-co-PDTDA were grown ...
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By Rik Ossenkoppele, Niels D. Prins, Yolande A.L. Pijnenburg, Afina W. Lemstra, Wiesje M. van der Flier, Sofie F. Adriaanse, Albert D. Windhorst, Ron L.H. Handels, Claire A.G. Wolfs, Pauline Aalten, Frans R.J. Verhey, Marcel M. Verbeek, Mark A. van Buchem, Otto S. Hoekstra, Adriaan A. Lammertsma, Philip Scheltens, Bart N.M. van Berckel Abstract: Background: [11C]Pittsburgh compound B ([11C]PIB) and [18F]-2-fluoro-2-deoxy-D-glucose ([18F]FDG) PET measure fibrillar amyloid-β load and glucose metabolism, respectively. We evaluated the impact of these tracers on the diagnostic process in a memory clinic population.Methods: One hundred fifty-four patients underwent paired dynamic [11C]PIB and static [18F]FDG PET scans shortly after completing Read & Research Alzheimers More. ...
Radiotracer development activities within the PET Facility focus primarily on neuroscience applications, with an emphasis on in vivo imaging of neurodegenerative disease pathology. Since its inception in 1992, Dr. Chester Mathis, Director of the PET Facility and Senior Radiochemist, has led these efforts. A long-standing collaboration with the laboratory of Dr. William E. Klunk, Dept. of Psychiatry, yielded the first successful PET imaging agent for imaging beta-amyloid (Aβ) plaques, an abnormal protein aggregate that is one of the pathologic hallmarks of Alzheimers Disease (AD). This agent, [11C]Pittsburgh Compound B (or [11C]PiB), continues to be an important investigational tool used worldwide in human AD research. A radiofluorinated analog of PiB developed by the PET Facility is under license to GE Healthcare, which is marketed as Vizamyl™ and approved by the U.S. FDA for clinical use. Currently, efforts in this area of research are focused on the development and application of PET ...
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Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane. Like most volatile amines, it possesses the somewhat unpleasant odour of rotten fish. It ignites readily, burning with a smoky flame characteristic of aromatic compounds. Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
HOPA = Hemalaun, Orange G, Phosphormolybdenic acid, Aniline blue Cell nuclei are stained with hemalaun or Weigerts iron-hematoxylin and then counterstained with a dye mixture of orange-phosphormolybden with aniline blue.. ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Visit ChemicalBook To find more Aniline(62-53-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Aniline(62-53-3). At last,Aniline(62-53-3) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
Latest China HS Code & tariff for n dimethyl aniline - Tariff & duty, regulations & restrictions, landed cost calculator, customs data for n dimethyl aniline in ETCN. China customs statistics trade data.
Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (between 15% and 30% (w/w)) of high molecular weight ((Mw)|120,000, and (Mn)|30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects,
Protein expression of CDK1 and p-CDK1 in rat spleens.(A) Western blot determination of CDK1 and p-CDK1 protein expression in control and aniline-treated rats. (
... Other names PhenylamineAminobenzeneBenzenamine Identifiers CAS number 62-53-3 SMILES NC1=CC=CC=C1 Properties Molecular formula C6H7N Molar mass
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for BENZENAMINE, 2-FLUORO-4-METHYL-, HYDROBROMIDE (CAS No. 874186-81-9)
21889-05-4 - BBYJHUAEFSHMHU-UHFFFAOYSA-N - Benzenamine, 4-(1H-indol-2-yl)- (9CI) - Similar structures search, synonyms, formulas, resource links, and other chemical information.
32971-60-1 - BZOLKXGJNJUPQQ-SAPNQHFASA-N - Benzenamine, 3,4-dichloro-N-(1-(2-propenyl)-2-piperidinylidene)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Searching for two-dimensional (2D) layered materials with diverse electronic conductivities is one of the leading topics in materials science. Herein, from first-principles calculations, we report the thickness-dependent conductivity of layered 2D polyaniline (PANI) structures. When PANI is thinned down to a
Page contains details about heparin-methacrylate/polyaniline dual networks . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Page contains details about polyaniline nanotube film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
A method is provided for the preparation of a conductive composition containing a polymerized aromatic amine wherein the aromatic amine is oxidatively polymerized in an acidic aqueous medium in the presence of an oxidizing agent, a doping agent and an aromatic polyalkyleneoxide in an amount sufficient to stabilize the resulting composition. Preferably, the aromatic amine is aniline or a substituted aniline. Compositions produced by such method are also disclosed. These compositions are useful for treating various substrates to make such substrates conductive.
Name: 2-Chloro-4-nitrobenzenamine CA Name: Benzenamine,2-chloro-4-nitro- Molecular Structure: 2-Chloro-4-nitrobenzenamine,Benzenamine,2-chloro-4-nitro-,CAS 121-87-9,172.57,C6H5ClN2O2 2-Chloro-4-nitrobenzenamine,Benzenamine,2-chloro-4-nitro-,CAS 121-87-9,172.57,C6H5ClN2O2 Molecular Formula:C6H5ClN2O2 Molecular Weight: 172.57 CAS Registry Number: 121-87-9
S-2765, which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm. Packaging 10mg Price US$68
Structure, properties, spectra, suppliers and links for: 4-(8-Methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline.
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This site lists all substances and their properties which are reported on in the indexed Landolt-Börnstein volumes. In total, 160 000 organic and inorganic compounds are described by names, molecular structures, chemical abstract numbers and other identifiers. Properties are directly linked to the full documents at Springerlink. Landolt-Börnstein citations are given as "Vol. LB-Group/Volume Chapter: number [, page]: document title" and have a hyperlink to the full-text of the document containing the substance. The short identifier of the LB volume leads to a complete denotation of the reference with a direct link to the respective volume. For several compounds crosslinks to some derivatives are provided, e.g. isotope-marked compounds, hydrates and hydrochlorides. For benzenamine (aniline) for example there is a direct link to the related compounds benzenamine-d7 and aniline hydrochloride/hydrobromide/hydroiodide. Additionally, EINECS numbers (European Inventory of Existing Commercial Chemical ...
4BC6: Crystal Structure of Human Serine Threonine Kinase- 10 Bound to Novel Bosutinib Isoform 1, Previously Thought to be Bosutinib
4BC6: Crystal Structure of Human Serine Threonine Kinase- 10 Bound to Novel Bosutinib Isoform 1, Previously Thought to be Bosutinib
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Matter is composed of atoms or groups of atoms called molecules. The arrangement of particles in a material depends on the physical state of the substance. In a solid, particles form a compact structure that resists flow. Particles in a liquid have more energy than those in a solid. They can flow past one another, but they remain close. Particles in a gas have the most energy. They move rapidly and are separated from one another by relatively large distances. ...
The solvate structure of 3,4-dichloro-1-nitro-benzene with aniline, 2C6H3Cl2NO2·C6H7N, is reported. Ribbons of 3,4-dichloro-nitro-benzene, formed by ClCl and N - OCl inter-actions, are linked together via N - HO hydrogen bonds with aniline into an undulating two-dimensional sheet.. ...
I will try these again, as I am really struggling with these compounds. Hard going back to school after all these years. 1. I will list the longest chain and then tell when items are placed above and below CH3-C=CH-CH-CH3 above C is ...
Comments about Pro-Tec Athletics The Orb Deep Tissue Massage Ball 5 Injury Recovery:. I am a fan of the trigger point foam roller but was recently on travel without it and needed a substitute. I was looking for a travel version of the grid roller but the store was out. An associate talked me into the orb and I wish I could go back and thank him! Great for general stiffness but also able to get into and isolate smaller areas. Very easy to throw into a suitcase or backpack. Seems durable so far but Ive only had it for a month. ...
Latest China HS Code & tariff for n dimethylaniline - Tariff & duty, regulations & restrictions, landed cost calculator, customs data for n dimethylaniline in ETCN. China customs statistics trade data.
Business Directory for Diphenylamine Suppliers in Mumbai - Get contact details of Diphenylamine Manufacturers, Wholesale Diphenylamine Exporters, Best Diphenylamine Traders & Distributors Across the Mumbai.
Experiments performed in mice in which expression of the extracellular calcium-sensing receptor (CaSR) was completely nullified specifically in parathyroid cells, chondrocytes, or cells of the osteoblast lineage have identified phenotypes that indicate a key role for the CaSR in embryonic development of the skeleton, postnatal bone formation, and osteoblast differentiation that are independent of the calcitropic hormone axis. These long-awaited studies further clarify the signaling relationships between the parathyroid gland, kidney, and metabolic bone disease in patients with mutations in the gene encoding the CaSR, and they provide new insights into understanding the signaling pathways involving the CaSR in skeletal cells.. ...
The present paper aims to study the preparation of polyaniline nanofibers through simple interfacial polymerization. Ammonium persulfate, hydrochloric acid and chloroform were used as oxidant, dopant and organic solvent respectively. Field Emission Scanning Electron Microscopy (FESEM), X-ray diffraction and Fourier Transform Infrared Spectroscopy (FTIR) techniques were used to analyze the product. FESEM results show that polyaniline has nano-fiber morphology. XRD results show the crystalline properties of polyaniline nanofiber, and FTIR results confirmed the formation of polyaniline in different monomer/oxidant molar ratios. This study provides a better understanding on the synthesis of uniform polyaniline nanofibers through interfacial polymerization.
Polyaniline shows great potential and promises wide application in the biomedical field thanks to its intrinsic conductivity and material properties, which closely resemble natural tissues. Surface properties are crucial, as these predetermine any interaction with biological fluids, proteins and cells. An advantage of polyaniline is the simple modification of its surface, e.g., by using various dopant acids. An investigation was made into the adhesion, proliferation and migration of mouse embryonic fibroblasts on pristine polyaniline films and films doped with sulfamic and phosphotungstic acids. In addition, polyaniline films supplemented with poly (2-acrylamido-2-methyl-1-propanesulfonic) acid at various ratios were tested. Results showed that the NIH/3T3 cell line was able to adhere, proliferate and migrate on the pristine polyaniline films as well as those films doped with sulfamic and phosphotungstic acids; thus, utilization of said forms in biomedicine appears promising. Nevertheless, ...
광여기된 안트라센은 N,N-dimethylaniline(DMA)과 같은 기저 상태의 전자주개와 안정한 착물인 excited complex(exciplex)를 형성하는 것으로 잘 알려져 있다. 본 연구에서는 exciplex 형성 및 분해 반응에 미치는 전자주개의 구조적인 영향을 알아보기 위해 DMA 유도체인 N,N-dimethyl-o-toluidine(DMOT), N,N-dimethyl-m-toluidine(DMMT), N,N-dimethyl-p-toluidine(DMPT), 4-tert-butyl-dimethylaniline(BDMA), N,N,2,4,6-pentamethylaniline(PMA) 등을 사용하였다. 측정 방법으로는 absorption과 emission 및 time resolved spectroscopy를 이용하였다. DMA 페닐 링의 meta나 para 위치 치환은 안트라센과의 exciplex 형성에 영향을 미치지 않았다. 특히 para위치에 tertiary 부틸기가 붙은 BDMA는 메틸 기가 붙은 DMPT와 비슷한 결과를 보여 para 위치에 치환된 그룹의 크기는 exciplex 형성에 큰 영향을 주지 않음을 알 수 있었다. 이와 달리, ortho 위치의 치환은 ...
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
D611 - 12(2016) Standard Test Methods for Aniline Point and Mixed Aniline Point of Petroleum Products and Hydrocarbon Solvents , aniline point, aromatics, mixed aniline point,,
The electropolymerization of o-aminophenol is markedly different from that of aniline and other aniline derivatives owing to the ease of generation of radical cations from the oxidation of the monomer. The growth of poly-o-aminophenol (POAP) therefore proceeds mainly through the reactions between the growing polymer and oxidized monomer molecules. The polymer matrix of POAP consists of both oxidized (quinonoid) and reduced (N-phenyl-p-phenylenediamine) repeating monomer units. The polymer is dark brown when it is oxidized at potentials greater than 0.13 V (vs. SCE), and light yellow when it is reduced at potentials lower than - 0.042 V. The polymer under potentiodynamic polarization can also give rise to a completely colourless intermediate oxidation state that is made up of an equal number of oxidized and reduced units. Except for good colour retention in the oxidized state, POAP is unsatisfactory in electrochromic applications owing to rate limitation in the heterogeneous charge-transfer step. ...
1Oloyede-Akinsulere, A.I., 2 Amoko, J. S., 3Sabejeje, A. J.. 1,2Department of Chemistry, Adeyemi College of Education, Ondo.. 3Department of Integrated Science, Adeyemi College of Education, Ondo.. Abstract Schiff bases [N-(phenyl)salicylaldimine], [N-(2-methoxyphenyl)salicylaldimine], [N-(4-chlorophenyl)salicylaldimine, [N-(5-chloro-2-methylphenyl)salicylaldimine were synthesized from 5-chlorosalicylaldehyde and aniline derivative. The synthesized compounds were characterized by elemental analysis, IR, UV, 1HNMR. The antibacterial studies revealed that the compounds exhibit broad spectrum antibacterial activity against Escheriochia coli, Klebsiella pneumonia, proteus mirabilis, Pseudomonas aeruginosa and Salmonella typhimurium.. Keywords: Salicylaldimine, antibacterial, aniline, Schiff base, chlorosalicylaldehyde ...
Objective: To investigate the particular pathology of the Arctic APP (APParc) early-onset familial Alzheimer disease (eoFAD) mutation for the first time in vivo with PET in comparison with other eoFAD mutations and sporadic Alzheimer disease (sAD).. Methods: We examined 2 APParc mutation carriers together with 5 noncarrier siblings cross-sectionally with C-11-labeled Pittsburgh compound B (PiB) and F-18-fluorodeoxyglucose (FDG) PET, as well as MRI, CSF biomarkers, and neuropsychological tests. Likewise, we examined 7 patients with sAD, 1 carrier of a presenilin 1 (PSEN1) mutation, 1 carrier of the Swedish APP (APPswe) mutation, and 7 healthy controls (HCs).. Results: Cortical PiB retention was very low in the APParc mutation carriers while cerebral glucose metabolism and CSF levels of A beta(1-42), total and phosphorylated tau were clearly pathologic. This was in contrast to the PSEN1 and APPswe mutation carriers revealing high PiB retention in the cortex and the striatum in combination with ...
TY - JOUR. T1 - Intermediates in the reaction of aniline with formaldehyde catalyzed by acids. AU - Bochkarev, V. V.. AU - Soroka, L. S.. PY - 2000/5/1. Y1 - 2000/5/1. N2 - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the semiempirical MNDO method. According to the calculation results, protonated N-(hydroxymethyl)aniline and ortho-, meta-, and paraσ-complexes are formed through the ion-dipole complex. Further transformations of these intermediates, which determine the structure of the final products, depend on the possibility of proton abstraction from the σ-complexes with formation of a quinonimine structure, as well as on the lability of the hydroxymethyl group in the protonated amino alcohol.. AB - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the ...
Aspirin and azo derivatives have been widely studied and have drawn considerable attention due to diverse biological activities. In this study, a series of 4-[(halophenyl)diazenyl]phenyl aspirinate derivatives were synthesized from the reaction of aspirin with 4-[(halophenyl)diazenyl]phenol via esterification, in the presence of DCC/DMAP in DCM with overall yield of 45-54%. 4-[(Halophenyl)diazenyl]phenol was prepared prior to esterification from coupling reaction of aniline derivatives and phenol in basic solution. All compounds were characterized using elemental analysis, FTIR, and 1H and 13C NMR spectroscopies. All compounds were screened for their anticancer activities against nasopharyngeal cancer (NPC) HK-1 cell lines and the viability of cultured cells was determined by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxylmethoxylphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]-based colorimetric assay. 4-[(E)-(Fluorophenyl)diazenyl]phenol showed the highest anticancer activity against NPC HK-1 cell ...
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
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12. Le texte indique : « 2,6-dimethylaniline (3.0 mL, 2.9 g, 24.4 mmol) ». Quelles relations lient ces valeurs. Vérifier les valeurs données. 13. Montrer que la quantité de matière de lidocaïne que lon devrait théoriquement obtenir est 24,4 mmol. Quelle serait alors la masse de lidocaïne obtenue ? 14. Le texte indique : « The yield of dry product is 4.1 grams, 71.1% based on 2,6-dimethylaniline». b) Quelle masse de lidocaïne est obtenue expérimentalement ? c) Montrer que la quantité de matière de lidocaïne que lon devrait théoriquement obtenir est 24,4 mmol. Quelle serait alors la masse de lidocaïne obtenue ? 15. Définir et calculer le rendement de cette synthèse. Auteur : Brigitte VRAY ...
The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
Electrically conducting polymers induce specific cellular responses at the molecular level. One of the crucial limitations of the use of conducting polymers in tissue engineering is their inability to degrade. The incorporation of conductivity into degradable polymers to obtain materials that are both electroactive and degradable is therefore highly anticipated. Architecture plays an important role in the performance of polymers. To be able to achieve the optimal mechanical, degradation, thermal and biological properties for a particular biomedical application, it is desirable to promote architectural diversity.. In the first part, by combining the electroactivity of conducting polymers and the degradability of aliphatic polyesters, we have designed and synthesized a series of linear, star-shaped, hyperbranched, and crosslinked degradable and electrically conducting polymers and hydrogels based on polylactide (PLA), polycaprolactone (PCL), and aniline oligomers such as aniline trimer, aniline ...
Polyaniline is a conducting polymer with incredible promise, but it has had limited use due to poor reaction control and processability associated with conventional morphologies. Polyaniline nanofibers, on the other hand, have demonstrated, through manufacturing techniques discovered during the past decade,
The applicability of air sampling methods for aniline (62533) to its substituted derivatives, o-toluidine (95534), N,N-dimethylaniline (121697), o-anisidine (90040), o-chloraniline (95512), and mixed xylidines, was investigated. Aniline air sampling employed a tube containing two 50 milligram sections of 45:60 mesh silica gel. The effectiveness of the first sorbent section was described by the qua
View Notes - Dolbier HW Solutions 231 from CHM 2210 at University of Florida. 225 ALKYNES Treatment of compound A with sodium amide converts it to compound B. Compound B on ozonolysis gives a diacid
A study was conducted to quantitate tissue macromolecular adduct formation after induction of drug metabolizing enzymes or long term oral administration of 4,4-methylenebis(2-chloroaniline) (101144) (MOCA), a model aromatic amine, in the rat. Male Sprague-Dawley- rats were administered carbon-14 (C-14) labeled MOCA at 28.1 micromole/kilogram (micromol/kg) daily for up to 28 days either by gavage
Growing demand for 4-Nitro Aniline from the paints and coatings and dye industry is the major factor driving the growth of global 4-Nitro Aniline market
Global Aniline Market was valued at US$ 9.75 Bn in 2013 and is likely to reach US$ 15.66 Bn by 2020, expanding at a CAGR of 7.0% during the forecast period between 2014 and 2020. In terms of volume, global demand for aniline stood at 5,470 kilo tons in 2013
Advice and warnings for the use of Florbetapir F 18 (Amyvid) during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out
A series of anthrazoline-containing monomers are synthesized, and eight co-polyamides of different chemical structures, containing 1,9-anthrazoline fragments in the main chain, are obtained and investigated. Photoluminescent, stress-strain, and thermal properties of these polymers are studied. It is shown that polymers with fragments of 4,4-(pyrido[3,2-g]-quinoline-2,8-diyl)dianiline and 4,4-(10-methylpyrido[3,2-g]quinoline-2,8-diyl)dianiline possess an intense luminescence in the range 550-650 nm. The performed investigations made it possible to determine the effect of substituents of various natures in the anthrazoline cycle and the position of amide group (meta- and para-configurations) on optical, stress-strain, and thermal properties of copolymers, opening up a prospect for further developments of principles of design of polymers with optimal characteristics ...
SWISS-MODEL Repository entry for Q28505 (FMO2_MACMU), Dimethylaniline monooxygenase [N-oxide-forming] 2. Macaca mulatta (Rhesus macaque)
Fluorescent Dyes , Enzyme Detection Reagents , Caspase 9 Substrate 1, chromogenic; pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.; Caspase-9 substrate; Ac-LEHD-pNA; Ac-Leu-Glu-His-Asp-pNA
GPR88, an orphan receptor richly expressed in the striatum, is implicated in a number of basal ganglia-associated disorders. In order to elucidate the functions of GPR88, an in vivo probe appropriate for CNS investigation is required. We previously reported that 2-PCCA was able to modulate GPR88-mediated cAMP production through a G alpha(i)-coupled pathway. Early structure-activity relationship (SAR) studies suggested that the aniline moiety of 2-PCCA is a suitable site for diverse modifications.
Find a comprehensive guide to possible side effects including common and rare side effects when taking Bosulif (Bosutinib Tablets) for healthcare professionals and consumers.
Two small prospective studies have investigated the extent to which cerebral Aß load, measured using PiB PET neuroimaging, is related to change in cognitive function in healthy older adults.8,11 As in the current study, the entire group of healthy older adults from the Melbourne Healthy Aging Study cohort showed no change in memory or nonmemory composite scores 18 or 36 months after a baseline PiB PET scan. However, when adults in this group were classified as having high or low cerebral Aß load, using the same criterion as that used in the current study, healthy older adults with high cerebral Aß load showed statistically significant decline of a moderate magnitude on both memory and nonmemory composite scores 36 months after PET scanning.8 However, by the 36-month assessment, 25% of healthy older adults with high cerebral Aß load met the clinical criteria for mild cognitive impairment (MCI). Thus, the general decline in cognition observed at 36 months postscan reflected this change in ...
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Graduates of University of Pittsburgh - the names, photos, skill, job, location. Information on the University of Pittsburgh - contacts, students, faculty, finances.
Graduates of University of Pittsburgh - the names, photos, skill, job, location. Information on the University of Pittsburgh - contacts, students, faculty, finances.
The best resource online for fast, confidential STD Testing in Pittsburgh, pennsylvania. Learn about STD Testing and why it is important to get tested regularly, at STDAware Pittsburgh.
The cost for Mold Removal in Pittsburgh, PA is between $1,941 and $2,302. To get a free detailed quote from a Pittsburgh pro click..
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Fastrac Pellets-Place Packs is one of the fastest acting rodent baits (Bromethalin). Fastrac Place Pack Pellets hold up in moist conditions.The hardness of the Fastrac Place Pack pellet also satisfies the rodents desire to gnaw.
A-1331852 is a potent and BCL-XL-selective inhibitor. BCL-XL is the major antiapoptotic survival protein and may be a novel therapeutic target in CML. BCL-XL-selective inhibitors have the potential to enhance the efficacy of docetaxel in solid tumors and avoid the exacerbation of neutropenia observed with navitoclax. A-1331852 may have potential as improved cancer therapeutics.
An incorrect isomer of the kinase inhibitor bosutinib is circulating in the biomedical research community, potentially throwing doubt on study results.
Learn about the potential side effects of Bosulif (bosutinib). Includes common and rare side effects information for consumers and healthcare professionals.
Scott MacIntyre, whose talent and determination captivated the nation as the first vision impaired American Idol finalist, is coming to Pittsburgh to benefit a local 100-year-old
The University of Pittsburgh is among the nations most distinguished comprehensive universities, with a wide variety of high-quality programs in both the arts and sciences and professional fields.
The University of Pittsburgh is among the nations most distinguished comprehensive universities, with a wide variety of high-quality programs in both the arts and sciences and professional fields.
Today was an informative, but exhausting, day in Pittsburgh for the travel team, as Auntie Mia called them in our latest email exchange :) Theyre a rockstar team as far as Im concerned!I spoke with Jenna for a while earlier this evening, and they spent about three and half hours with Dr. Escolar and her…
Pittsburgh Compline Choir Home Page . 160;: the Angelus of the University of Pittsburgh, 1787-1987. Pittsburgh, PA: University of Pittsburgh Press.
Hi Everyone, Well, our long awaited visit to the Sclero specialist in Pittsburgh was Wed. and I am so disappointed. Basically, yes, Gareth has Esoph dism...
Barrie Cassileth, PhD, Laurance S. Rockefeller Chair in Integrative Medicine and Chief, Integrative Medicine Service, at Memorial Sloan Kettering Cancer Center (MSKCC) in New York has published a new book called Survivorship: Living Well During and After Cancer. Dr. Cassileth provides readers with up-to-date, evidence-based guidance about integrative medicine along with important information for cancer patients and their families. She explains how acupuncture, massage therapy, yoga, nutritional counseling, and other integrative approaches may be helpful in alleviating both short- and long-term side effects of cancer and its treatments.. Importantly, Dr. Cassileth also helps to separate the facts from the hype in integrative medicine and to guide readers through cancer treatment and beyond. For more information about Survivorship: Living Well During and After Cancer, visit http://bit.ly/1dvIoq3 ■. ...
Instructions for use: Use on moisturized skin for all-over radiance Mix into foundation for a subtle shimmer Apply to cheeks, brow bone and décolleté to highlight 30ml/ 1fl.oz. Ingredients: Water (Aqua), Isohexadecane, Dimethicone, Nylon-12, Talc, Mica, Glycerin, Ipdi/Di-C12-13 Alkyl, Tartrate/Bis-Hydroxyethoxypropyl Dimethicone Copolymer, Trisiloxane, Isododecane, Titanium Dioxide (Ci 77894), Squalane, Sorbitan Isostearate, Cetyl Peg/Ppg-10/1 Dimethicone, Synthetic Beeswax, Tetrasodium Edta, Phenoxyethanol, Sodium Chloride, Disteardimonium Hectorite, Alcohol, Potassium Sorbate, Silica Dimethyl Silylate, Peg-30 Dipolyhydroxystearate, Iron Oxides (Ci 77491), Propylene Carbonate, Mannitol, Di C12-13 Alkyl Tartrate, Cyclodextrin, Tin Oxide, Glycogen, Tocopherol, Arctostaphylos Uva Ursi Leaf Extract, Rubus Idaeus Leaf Cell Culture, Pentaerythrityl Tetra-Di-1-Butyl, Hydroxyhydrocinnamate
An inclusion complex of β-cyclodextrin and 4-aminothiophenol was assembled by hydrophobic interaction of the host (β-cyclodextrin) and guest (4-aminothiophenol). The complex was isolated as crystalline solid and studied by single crystal X-ray diffraction method along with NMR and IR spectroscopy. Two cyclodextrin rings each containing one disulfide form of 4-aminothiophenol were found to pair up by hydrogen bonding of the outer rim -OH groups. The phenyl disulfide moiety of 4-aminophenyl disulfide molecule was found in the core of β-cyclodextrin, while the amino functional groups were positioned to the exterior of the cyclodextrin ring. Phenyl rings of the guest molecule from each partner of the paired cyclodextrin complex were found parallel to each other, indicating possible π-π stacking interaction between them.
Dubai Aniline 2 5 Disulfonic Acid, Buy High Quality Aniline 2 5 Disulfonic Acid Products from Dubai Aniline 2 5 Disulfonic Acid Suppliers and Manufacturers at Dubai Yellow Pages Online
The relative effectiveness of 106 chemical compounds in inhibiting the function of the thyroid gland was tested in young rats. When these substances were administered in the food or drinking water for a period of ten days, the degree of thyroid hyperplasia, as estimated by gross and microscopic examination, provided an estimate of their activity.. Two classes of compounds were found to be active: thiourea derivatives and certain derivatives of aniline. The compounds more effective than thiourea in decreasing order of activity were : 2-thiouracil, 2-thiobarbituric acid, sym.-diethylthiourea and 5-benzal-2-thiohydantoin. The effective aniline derivatives comprised the sulfonamides, p-, m-, o-aminobenzoic acids, p-aminophenylacetic acid and p-aminoacetanilide. Thiocyanates were found to cause thyroid enlargement only in the absence of added iodide, while organic cyanides failed to influence the thyroid gland.. ...
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Highlights: • AgNWs/PANI transparent electrode was prepared by layer-by-layer coating method. • The surface roughness of the electrode reached to 6.5 nm (root mean square). • The electrode had reasonable sheet resistance (25 Ω/□) and transmittance (83.5%). - Abstract: Silver nanowires (AgNWs) are as potential candidates to replace indium tin oxide (ITO) in transparent electrodes because of their preferred conducting and optical properties. However, their rough surface properties are not favorable for the fabrication of optoelectronic devices, such as displays and thin-film solar cells. In the present investigation, AgNWs/polyaniline composite transparent electrodes with better surface properties were successfully prepared. AgNWs were incorporated into polyaniline:polystyrene sulfonate (PANI:PSS) by layer-by-layer coating and mechanical pressing. PANI:PSS decreased the surface roughness of the AgNWs electrode by filling the gap of the random AgNWs network. The transparent composite ...
Although most patients with GIST initially respond to therapy, 10% to 20% of patients still exhibit primary resistance to imatinib. Primary resistant tumors either carry no mutations in KIT or PDGFRA, or harbor specific activation loop mutations in KIT or PDGFRA, including the PDGFRAD842V mutation (3, 5, 8). The D842V mutation is the most common activating PDGFRA mutation in GIST, which has also been identified as a mechanism of secondary resistance to imatinib (12).. The development of primary and secondary resistance of GIST toward imatinib is emerging as a significant clinical challenge. Therefore, it is important to validate novel therapeutic strategies for the specific KIT and PDGFRA genotypes.. Second-generation tyrosine kinase inhibitors, nilotinib and dasatinib, inhibit the kinase activity of the wild-type PDGFRA (7, 14, 20, 21). The activity of sorafenib in this regard is unknown. Given the lack of in vivo models for PDGFRA mutant isoforms, in vitro experiments using transformed Ba/F3 ...
Page contains details about polypyrrole coated polyaniline coated multi-walled carbon nanotubes sponges . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
2016 Global and Chinese 3,5 Dichloroaniline (CAS 626-43-7) Industry Market Research Report is a market research report available at US $2800 for a Single User PDF License from RnR Market Research Reports Library.

Aniline Compounds - Phenotypes | CTDAniline Compounds - Phenotypes | CTD

benzenetetraamine promotes the reaction [[Plant Extracts results in increased negative regulation of extracellular matrix disassembly] which results in increased negative regulation of cell motility ...
more infohttp://ctd.mdibl.org/detail.go?type=chem&acc=D000814&view=phenotype

Etherate, pyridine, and aniline compounds of the complex tri- and tetra-iodoacids of Zn(II) and Cd(II) | SpringerLinkEtherate, pyridine, and aniline compounds of the complex tri- and tetra-iodoacids of Zn(II) and Cd(II) | SpringerLink

... and the properties of the title compounds are described. Analytical conductometric, spectral (infrared and ultraviolet) and ... Etherate, pyridine, and aniline compounds of the complex tri- and tetra-iodoacids of Zn(II) and Cd(II). ... The existence of metal-nitrogen bond for all pyridine and aniline complexes, except H2CdI4·4An (An=aniline), is adduced from ... The preparation, for the first time, and the properties of the title compounds are described. Analytical conductometric, ...
more infohttps://link.springer.com/article/10.1007/BF00899248

Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101 | Environmental XPRTSurface Decontamination of Amine Compounds (Aniline) by DeconGel 1101 | Environmental XPRT

... and concrete surfaces contaminated with amine compounds (aniline) w... ... Aniline) by DeconGel 1101. AbstractSurface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, ... No comments were found for Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101. Be the first to comment! ... Aniline was chosen as a representative amine compounds (industrial plastics feedstock); DeconGel is expected to have similar ...
more infohttps://www.environmental-expert.com/articles/surface-decontamination-of-amine-compounds-aniline-by-decongel-1101-542872

Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds (Journal Article) | DOE...Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds (Journal Article) | DOE...

Title: Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds. ... "Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds". Germany. doi:10.1002/ ... title = {Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds},. author = { ... Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds ...
more infohttps://www.osti.gov/pages/biblio/1400453-mesoporous-manganese-oxide-catalyzed-aerobic-oxidative-coupling-anilines-aromatic-azo-compounds

Polarizabilities and Orientational Order  Parameter in N-(p-n-Ethoxybenzylidene)- p-n-Alkoxy Anilines, 2O.Om LC CompoundsPolarizabilities and Orientational Order Parameter in N-(p-n-Ethoxybenzylidene)- p-n-Alkoxy Anilines, 2O.Om LC Compounds

It is observed in these compounds case as in other LC compounds Vuks isotropic model is favored compared to that of anisotropic ... p-n-alkoxy anilines, 2O.Om with m = 3 to 10 liquid crystalline compounds except with m = 5 which has been already published. ... The rest of the compounds exhibit the nematic LC phase except with m = 10 which shows the smectic-C phase along the nematic ... nO.m and nO.Om compounds play an important role in the fundamental and applied aspects. As a part of our systematic studies of ...
more infohttps://www.scirp.org/journal/PaperInformation.aspx?PaperID=69199

Mechanochemical removal of organo-chlorinated compounds by inorganic components of soil.Mechanochemical removal of organo-chlorinated compounds by inorganic components of soil.

0/Aniline Compounds; 0/Ferric Compounds; 0/Manganese Compounds; 0/Polychlorinated Biphenyls; 0/Silicates; 0/Soil; 0/Soil ... Aniline Compounds / chemistry*. Catalysis. Environmental Pollution / prevention & control. Ferric Compounds. Ferritins / ... Manganese Compounds / chemistry. Pentachlorophenol / chemistry*. Polychlorinated Biphenyls / chemistry*. Silicates / chemistry ... The efficiency of the mechanochemical removal was compared with batch experiments for the soluble compounds (PCP and 4-CA). The ...
more infohttp://www.biomedsearch.com/nih/Mechanochemical-removal-organo-chlorinated-compounds/15099728.html

Effects of SEA0400 on arrhythmogenicity in a Langendorff-perfused 1-month myocardial infarction rabbit model. | CureHunterEffects of SEA0400 on arrhythmogenicity in a Langendorff-perfused 1-month myocardial infarction rabbit model. | CureHunter

Aniline Compounds (administration & dosage, adverse effects) *Animals. *Anti-Arrhythmia Agents (administration & dosage, ...
more infohttp://www.curehunter.com/public/pubmed23380010.do

Angiosarcoma of the Liver Among Polyvinyl Chloride Workers  --
KentuckyAngiosarcoma of the Liver Among Polyvinyl Chloride Workers -- Kentucky

... bladder cancer in dye workers exposed to aniline compounds; leukemia and lymphoma in chemical workers exposed to benzene; ... more quickly after the introduction of new chemical compounds, and in more severe forms. ...
more infohttps://www.cdc.gov/mmwr/preview/mmwrhtml/lmrk103.htm

Rosaniline Dyes
      - Fuchsin
     Summary Report | CureHunterRosaniline Dyes - Fuchsin Summary Report | CureHunter

Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta ... Fuchsin; Triphenylmethane Aniline Compounds; Aniline Compounds, Triphenylmethane; Compounds, Triphenylmethane Aniline; Dyes, ... Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta ...
more infohttp://www.curehunter.com/public/keywordSummaryD012394-Rosaniline-Dyes-Fuchsin.do

3-(Trifluoromethylthio)aniline 369-68-6 Precursor & Downstream   Compound Dictionary3-(Trifluoromethylthio)aniline 369-68-6 Precursor & Downstream Compound Dictionary

... aniline Precursor products, 3-(Trifluoromethylthio)aniline Downstream products ect. ... Current Page: Home › Chemical Dictionary › 369-68-6 › 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Products ... 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Downstream Products Precursor:. 404-74-0 79576-16-2 370-47-8 90109-81-2 ...
more infohttp://www.molbase.com/en/precursor_369-68-6-moldata-8997.html

Toxic Chemical Decontamination  Articles  on Environmental XPRTToxic Chemical Decontamination Articles on Environmental XPRT

Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101 Abstract Surface decontamination efficacy determination ... Surface Decontamination of Cadmium Compounds (Cadmium Chloride (CdCl2) and Cadmium Oxide (CdO)) by DeconGel 1101 OBJECTIVE The ... Surface Decontamination of Cyanide Compounds (Potassium Ferricyanide (K3[Fe(CN)6])) by DeconGel 1101 ABSTRACT Surface ... Surface Decontamination of Tin compounds (tributyltin chloride) by DeconGel 1101 Abstract Surface decontamination efficacy of ...
more infohttps://www.environmental-expert.com/articles/keyword-toxic-chemical-decontamination-12987

The aza-Michael reaction in a diluted solution (0.025   | Open-iThe aza-Michael reaction in a diluted solution (0.025 | Open-i

This approach not only provides more insight into the origin of life but also offers a pathway to acquire enantiopure compounds ... This approach not only provides more insight into the origin of life but also offers a pathway to acquire enantiopure compounds ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC4263183_ncomms6543-f2&req=4

carcinoma of female genitalia drug 2000:2010[pubdate] *count=100 - BioMedLib™ search enginecarcinoma of female genitalia drug 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

MeSH-major] Aniline Compounds / toxicity. Antipsychotic Agents / toxicity. Carcinogens / toxicity. Chlorpromazine / toxicity. ... Chemical-registry-number] 0 / Aniline Compounds; 0 / Antipsychotic Agents; 0 / Carcinogens; 4C11L78UR3 / cresidine; U42B7VYA4P ... Organophosphorus Compound. A1.4.1.2.1.7. Amino Acid, Peptide, or Protein. A1.4.1.2.1.8. Carbohydrate. A1.4.1.2.1.9. Lipid. A1.4 ... This review will discuss the evidence from both animal studies and humans for an effect of these ubiquitous compounds on the ...
more infohttp://www.bmlsearch.com/?kwr=carcinoma+of+female+genitalia+drug+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

cleaved cell lymphoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginecleaved cell lymphoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine

MeSH-major] Aniline Compounds / pharmacology. Antineoplastic Agents / pharmacology. Lymphoma, Large B-Cell, Diffuse / pathology ... Chemical-registry-number] 0 / Aniline Compounds; 0 / Antineoplastic Agents; 0 / Sulfonamides; W36ZG6FT64 / Sirolimus; ... Organophosphorus Compound. A1.4.1.2.1.7. Amino Acid, Peptide, or Protein. A1.4.1.2.1.8. Carbohydrate. A1.4.1.2.1.9. Lipid. A1.4 ... In this study, we analyzed the response of four T-ALL cell lines to compound E, a potent gamma-secretase inhibitor, and to the ...
more infohttp://www.bmlsearch.com/?kwr=cleaved+cell+lymphoma+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1

Silver nitrite - WikipediaSilver nitrite - Wikipedia

Notable examples include: The production of aniline compounds. General oxidizing agent. Victor Meyer type nucleophilic ... Silver nitrite is an inorganic compound with the formula AgNO2. Silver nitrite has many applications. ... substitution reactions with organobromides or organoiodides forming nitro compounds. Nitroalkene synthesis with nitryl iodide ...
more infohttps://en.wikipedia.org/wiki/Silver_nitrite

Annals of Agricultural Sciences - Journal - ElsevierAnnals of Agricultural Sciences - Journal - Elsevier

Antioxidant and structure-activity relationships (SARs) of some phenolic and anilines compounds E. Bendary , R. R. Francis ... Antioxidant and structure-activity relationships (SARs) of some phenolic and anilines compounds E. Bendary , R. R. Francis ...
more infohttps://www.journals.elsevier.com/annals-of-agricultural-sciences/

Welcome to LibAge, the ageing reference resourceWelcome to LibAge, the ageing reference resource

Entries tagged Aniline Compounds/pharmacology (1). Sort:. Number of citations. Author. Title. Year. PubMed ID. ...
more infohttp://libage.ageing-map.org/entries/tags/8433/

Cancer cluster - WikipediaCancer cluster - Wikipedia

... bladder cancer in dye workers exposed to aniline compounds; and leukemia and lymphoma in chemical workers exposed to benzene. ...
more infohttps://en.wikipedia.org/wiki/Cancer_cluster

TW201302064A - Agricultural or horticultural fungicide composition and method for controlling plant pathogen 
      - Google...TW201302064A - Agricultural or horticultural fungicide composition and method for controlling plant pathogen - Google...

... a strobilurin compound or its salt to a plant or a soil is provided. ... a strobilurin compound or its salt is provided; in addition, a method for controlling a plant pathogen by applying the subject ... An aniline compound such as (bixafen), (isothianil), tiadinil, (sedaxane); a sulfonamide compound such as dichlofluanid; such ... such as a dinitro compound Organic sulfur compound; urea compound; triazabenzene compound; lanthanide compound; further, as ...
more infohttps://patents.google.com/patent/TW201302064A/en

96-96-8 - 4-Methoxy-2-nitroaniline, 99% - 4-Amino-3-nitroanisole - 2-Nitro-p-anisidine - A11673 - Alfa Aesar96-96-8 - 4-Methoxy-2-nitroaniline, 99% - 4-Amino-3-nitroanisole - 2-Nitro-p-anisidine - A11673 - Alfa Aesar

4-Methoxy-2-nitroaniline is an aniline compound used in the synthesis of dyes and pigments. It has also been shown to act as a ... Also used as an intermediate for the synthesis of dyes, pigments and other chemical compounds. ...
more infohttps://www.alfa.com/en/catalog/A11673/

Frost, C.<...Frost, C.<...

Regioselective Transition-Metal-Catalyzed C-H Functionalization of Anilines. Leitch, J. A. & Frost, C. G., 11 Jun 2018, In : ... Rhodium Chemical Compounds phosphine Chemical Compounds Ligands Chemical Compounds Palladium Chemical Compounds ...
more infohttps://researchportal.bath.ac.uk/en/persons/christopher-frost

Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-met by Chengxin Zhi, Zheng-yu Long et al."Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-met" by Chengxin Zhi, Zheng-yu Long et al.

Most compounds were potent competitive inhibitors of pol IIIC (K(i)s 0.02-0.5 microM), and those with neutral, moderately polar ... Certain intermediates, e.g. the 3-(iodoalkyl) compounds, were converted to a variety of (3-substituted-alkyl)-EMAUs by ... Several compounds protected mice from lethal intraperitoneal (ip) infections with S. aureus (Smith) when given by the ip route ... to effect displacement of the 6-amino group and simultaneous demethylation of the 2-methoxy group to yield target compounds in ...
more infohttps://escholarship.umassmed.edu/gsbs_sp/659/

Chemical Database: 4,4\-Methylenedianiline (EnvironmentalChemistry.com)Chemical Database: 4,4\'-Methylenedianiline (EnvironmentalChemistry.com)

4,4-Methylenebis(aniline) *4,4-Methylenebis(aniline) , compound with sodium chloride (3:1) *4,4-Methylenebis(benzeneamine) * ... 4-(4-Aminobenzyl) aniline*Ancamine TL*Aniline, 4,4-methylenedi-*Aniline, 4,4-methylenedi-, dihydrochloride*Araldite hardener ... Methylenebis (aniline) *Methylenebis(aniline) *Methylenedianiline*Methylenedianiline (VAN) *METHYLENEDIANILINE DIHYDROCHLORIDE* ... Some chemicals listed in this database or not pure chemical compounds, rather they are mixtures/solutions of chemicals. It is ...
more infohttps://environmentalchemistry.com/yogi/chemicals/cn/4%2C4%27-Methylenedianiline.html

Osimertinib - AstraZeneca - AdisInsightOsimertinib - AstraZeneca - AdisInsight

Class Acrylamides; Aniline compounds; Antineoplastics; Dimethylamines; Indoles; Pyrimidines; Small molecules * Mechanism of ...
more infohttp://adisinsight.springer.com/drugs/800037784?error=cookies_not_supported&code=37d8dada-65b7-4c33-8e3b-be6cae658621
  • The crude sample was subjected to repeated recrystallization from absolute ethanol in cold to give the pure compound, until the transition temperatures are constant. (scirp.org)
  • The rest of the compounds exhibit the nematic LC phase except with m = 10 which shows the smectic-C phase along the nematic phase which is originally not detected by Godzwon et al. (scirp.org)
  • The BH3-mimetic ABT-737 and an orally bioavailable compound of the same class, navitoclax (ABT-263), have shown promising antitumor efficacy in preclinical and early clinical studies. (edu.au)
  • The preparation, for the first time, and the properties of the title compounds are described. (springer.com)
  • This paper presents the refractive index results with temperature and the evaluation of dα and Dα in number of LC compounds of the homologous series, N-(p-n-ethoxybenzylidene)-p-n-alkoxy anilines, 2O.Om where m = 3, 4 and 6 to 10. (scirp.org)
  • These results have profound implications for how BH3-mimetics induce apoptosis and how the use of these compounds can be optimized for treating lymphoid malignancies. (edu.au)
  • Decontamination efficacies of DeconGel 1101 were 100% for aniline on all surfaces evaluated including concrete, stainless steel and aluminum as determined by residual swipe analysis. (environmental-expert.com)