Aniline CompoundsAniline Hydroxylase: A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.Aniline Mustard: Alkylating anti-neoplastic agent.ToluidinesAminophenols: Phenols substituted in any position by an amino group.Aminopyrine N-DemethylaseBiodegradation, Environmental: Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.Harmine: Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Benzphetamine: A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)Amination: The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.Delftia: A genus of gram-negative, strictly aerobic chemoorganotrophic bacteria, in the family COMAMONADACEAE.Catechols: A group of 1,2-benzenediols that contain the general formula R-C6H5O2.Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)Azo CompoundsHexobarbital: A barbiturate that is effective as a hypnotic and sedative.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Cytochrome P-450 Enzyme System: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Delftia acidovorans: A species of gram-negative rod-shaped bacteria found ubiquitously and formerly called Comamonas acidovorans and Pseudomonas acidovorans. It is the type species of the genus DELFTIA.Sulfur Compounds: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.Amines: A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Volatile Organic Compounds: Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.Propanil: A chlorinated anilide that is used as an herbicide.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Mixed Function Oxygenases: Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.Ethylmorphine: A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.IminesPalladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.Water Pollutants: Substances or organisms which pollute the water or bodies of water. Use for water pollutants in general or those for which there is no specific heading.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Oxidative Coupling: The reaction of two molecular entities via oxidation usually catalyzed by a transition metal compound and involving dioxygen as the oxidant.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Oxygenases: Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.Kinetics: The rate dynamics in chemical or physical systems.Chemistry, Organic: The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Acinetobacter: A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.Hydroxylation: Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Acetone: A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.o-Aminoazotoluene: An azo dye with carcinogenic properties.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Cyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Quinacrine Mustard: Nitrogen mustard analog of quinacrine used primarily as a stain in the studies of chromosomes and chromatin. Fluoresces by reaction with nucleic acids in chromosomes.Decontamination: The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.Hazardous Substances: Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Environmental Pollutants: Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.Water Pollutants, Chemical: Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.Xanthine: A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.

Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes. (1/1809)

1. The time courses of Ca2+ current and Ca2+ spark occurrence were determined in single rat ventricular myocytes voltage clamped with patch pipettes containing 0.1 microM fluo-3. Acquisition of line-scan images on a laser scanning confocal microscope was synchronized with measurement of Cd2+-sensitive Ca2+ currents. In most cells, individual Ca2+ sparks were observed by reducing Ca2+ current density with nifedipine (0.1-8 microM). 2. Ca2+ sparks elicited by depolarizing voltage-clamp pulses had a peak [Ca2+] amplitude of 289 +/- 3 nM with a decay half-time of 20.8 +/- 0.2 ms and a full width at half-maximum of 1.40 +/- 0.03 microm (mean +/- s. e.m., n = 345), independent of the membrane potential. 3. The time between the beginning of a depolarization and the initiation of each Ca2+ spark was calculated and data were pooled to construct waiting time histograms. Exponential functions were fitted to these histograms and to the decaying phase of the Ca2+ current. This analysis showed that the time constants describing Ca2+ current and Ca2+ spark occurrence at membrane potentials between -30 mV and +30 mV were not significantly different. At +50 mV, in the absence of nifedipine, the time constant describing Ca2+ spark occurrence was significantly larger than the time constant of the Ca2+ current. 4. A simple model is developed using Poisson statistics to relate macroscopic Ca2+ current to the opening of single L-type Ca2+ channels at the dyad junction and to the time course of Ca2+ spark occurrence. The model suggests that the time courses of macroscopic Ca2+ current and Ca2+ spark occurrence should be closely related when opening of a single L-type Ca2+ channel initiates a Ca2+ spark. By comparison with the data, the model suggests that Ca2+ sparks are initiated by the opening of a single L-type Ca2+ channel at all membrane potentials encountered during an action potential.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/1809)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/1809)

Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia.  (+info)

Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. (4/1809)

Myeloperoxidase is the most abundant protein in neutrophils and catalyzes the production of hypochlorous acid. This potent oxidant plays a central role in microbial killing and inflammatory tissue damage. 4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation. We have investigated the mechanism by which benzoic acid hydrazides (BAH) are oxidized by myeloperoxidase, and we have determined the features that enable them to inactivate the enzyme. BAHs readily reduced compound I of myeloperoxidase. The rate constants for these reactions ranged from 1 to 3 x 10(6) M-1 s-1 (15 degrees C, pH 7.0) and were relatively insensitive to the substituents on the aromatic ring. Rate constants for reduction of compound II varied between 6.5 x 10(5) M-1 s-1 for ABAH and 1.3 x 10(3) M-1 s-1 for 4-nitrobenzoic acid hydrazide (15 degrees C, pH 7.0). Reduction of both compound I and compound II by BAHs adhered to the Hammett rule, and there were significant correlations with Brown-Okamoto substituent constants. This indicates that the rates of these reactions were simply determined by the ease of oxidation of the substrates and that the incipient free radical carried a positive charge. ABAH was oxidized by myeloperoxidase without added hydrogen peroxide because it underwent auto-oxidation. Although BAHs generally reacted rapidly with compound II, they should be poor peroxidase substrates because the free radicals formed during peroxidation converted myeloperoxidase to compound III. We found that the reduction of ferric myeloperoxidase by BAH radicals was strongly influenced by Hansch's hydrophobicity constants. BAHs containing more hydrophilic substituents were more effective at converting the enzyme to compound III. This implies that BAH radicals must hydrogen bond to residues in the distal heme pocket before they can reduce the ferric enzyme. Inactivation of myeloperoxidase by BAHs was related to how readily they were oxidized, but there was no correlation with their rate constants for reduction of compounds I or II. We propose that BAHs destroy the heme prosthetic groups of the enzyme by reducing a ferrous myeloperoxidase-hydrogen peroxide complex.  (+info)

A comparison of electron-capture GLC, electrolytic-conductivity GLC and UV-absorption HPLC for the analysis of some herbicides in foods. (5/1809)

A comparison of gas chromatography with electron-capture or electrolytic-conductivity (nitrogen mode) detection, and high-pressure liquid chromatography (HPLC) with UV-absorption detection (254 nm) was carried out for the analysis of several herbicides in foods. Linuron, propanil, terbacil, benzoylprop-ethyl, and the fungicide DCNA in samples of cabbage, corn, potato, and wheat spiked at 2 and 0.2 ppm were examined. The pesticides were extracted with acetone, partitioned into petroleum ether-methylene chloride, and cleaned up on a 2% deactivated Florisil column before direct chromatographic analysis. Electron-capture gas-liquid chromatography (GLC) was most suitable for DCNA and benzoylprop-ethyl while UV-absorption HPLC was best for terbacil analysis. Linuron and propanil gave similar results for both electron-capture GLC and HPLC. Electrolytic-conductivity GLC could detect all pesticides at the 0.2 ppm level and exhibited the least number of extraneous peaks in the chromatograms.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (6/1809)

We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. (7/1809)

We investigated the effects of a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl)ureido]methyl]cyclohexane), on ACAT activities in macrophages originating from several species and high-density lipoprotein (HDL)-induced cholesterol efflux in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells. NTE-122 inhibited cell-free ACAT activities in human PMA-treated THP-1 cells and mouse J774.1 cells with IC50 values of 0.88 and 360 nM, respectively. NTE-122 competively inhibited the ACAT activity in PMA-treated THP-1 cells. NTE-122 also inhibited cellular ACAT activities in PMA-treated THP-1 cells, rat peritoneal macrophages and J774.1 cells with IC50 values of 3.5, 84 and 6800 nM, respectively. Furthermore, NTE-122 prevented cholesterol accumulation in PMA-treated THP-1 cells incubated with acetylated low density lipoprotein, simultaneously with HDL, while it caused accumulation of a significant amount of free cholesterol in the absence and even in the presence of HDL. NTE-122 also enhanced HDL-induced cholesterol efflux from established foam cells converted from PMA-treated THP-1 cells. These results suggest that NTE-122, capable of inhibiting macrophage ACAT activity in humans more strongly than those in the other species, exhibits anti-atherogenic effects by preventing the foam cell formation and enhancing the foam cell regression in humans.  (+info)

Regulation of Ca2+ transport by sarcoplasmic reticulum Ca2+-ATPase at limiting [Ca2+]. (8/1809)

The factors regulating Ca2+ transport by isolated sarcoplasmic reticulum (SR) vesicles have been studied using the fluorescent indicator Fluo-3 to monitor extravesicular free [Ca2+]. ATP, in the presence of 5 mM oxalate, which clamps intravesicular [Ca2+] at approximately 10 microM, induced a rapid decline in Fluo-3 fluorescence to reach a limiting steady state level. This corresponds to a residual medium [Ca2+] of 100 to 200 nM, and has been defined as [Ca2+]lim, whilst thermodynamic considerations predict a level of less than 1 nM. This value is similar to that measured in intact muscle with Ca2+ fluophores, where it is presumed that sarcoplasmic free [Ca2+] is a balance between pump and leaks. Fluorescence of Fluo-3 at [Ca2+]lim was decreased 70% to 80% by histidine, imidazole and cysteine. The K0.5 value for histidine was 3 mM, suggesting that residual [Ca2+]lim fluorescence is due to Zn2+. The level of Zn2+ in preparations of SR vesicles, measured by atomic absorption, was 0.47+/-0.04 nmol/mg, corresponding to 0.1 mol per mol Ca-ATPase. This is in agreement with findings of Papp et al. (Arch. Biochem. Biophys., 243 (1985) 254-263). Histidine, 20 mM, included in the buffer, gave a corrected value for [Ca2+]lim of 49+/-1.8 nM, which is still higher than predicted on thermodynamic grounds. A possible 'pump/leak' mechanism was tested by the effects of varying active Ca2+ transport 1 to 2 orders with temperature and pH. [Ca2+]lim remained relatively constant under these conditions. Alternate substrates acetyl phosphate and p-NPP gave similar [Ca2+]lim levels even though the latter substrate supported transport 500-fold slower than with ATP. In fact, [Ca2+]lim was lower with 10 mM p-NPP than with 5 mM ATP. The magnitude of passive efflux from Ca-oxalate loaded SR during the steady state of [Ca2+]lim was estimated by the unidirectional flux of 45Ca2+, and directly, following depletion of ATP, by measuring release of 40Ca2+, and was 0.02% of Vmax. Constant infusion of CaCl2 at [Ca2+]lim resulted in a new steady state, in which active transport into SR vesicles balances the infusion rate. Varying infusion rates allows determination of [Ca2+]-dependence of transport in the absence of chelating agents. Parameters of non-linear regression were Vmax=853 nmol/min per mg, K0.5(Ca)=279 nM, and nH(Ca)=1.89. Since conditions employed in this study are similar to those in the sarcoplasm of relaxed muscle, it is suggested that histidine, added to media in studies of intracellular Ca2+ transients, and in the relaxed state, will minimise contribution of Zn2+ to fluophore fluorescence, since it occurs at levels predicted in this study to cause significant overestimation of cytoplasmic free [Ca2+] in the relaxed state. Similar precautions may apply to non-muscle cells as well. This study also suggests that [Ca2+]lim in the resting state is a characteristic feature of Ca2+ pump function, rather than a balance between active transport and passive leakage pathways.  (+info)

Ly et al: CAA Predisposes to rt-PA Related Hhemorrhage Cerebral b-Amyloid Detected by Pittsburgh Compound B Positron Emission Topography Predisposes to Recombinant Tissue Plasminogen Activator-Related Hemorrhage John V. Ly,1 Christopher C. Rowe,2 Victor L. Villemagne,2 Jorge A. Zavala,1 Henry Ma,1 Graeme OKeefe,2 Sylvia J. Gong,2 Rico Gunawan,1 Leonid Churilov,1 Tim Saunder,2 Uwe Ackerman,2 Henri Tochon-Danguy,2 and Geoffrey A. Donnan1,3 Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral b-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, ...
Name: 2,6-Dichioro-4-nitroaniline CA Name: Benzenamine,2,6-dichloro-4-nitro- Molecular Structure: 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 Molecular Formula:C6H4Cl2N2O2 Molecular Weight: 207.00 CAS Registry Number: 99-30-9
5-chloro-2-methyl-4-nitroaniline chemical properties, What are the chemical properties of 5-chloro-2-methyl-4-nitroaniline 13852-51-2, What are the physical properties of 5-chloro-2-methyl-4-nitroaniline ect.
3-Methyl-4-nitroaniline chemical properties, What are the chemical properties of 3-Methyl-4-nitroaniline 611-05-2, What are the physical properties of 3-Methyl-4-nitroaniline ect.
2-Bromo-5-nitroaniline, 98%, ACROS Organics™ 25g; Glass bottle 2-Bromo-5-nitroaniline, 98%, ACROS Organics™ Bromomethylphenyl to Bromophenyla -Organics
... aims at providing comprehensive data on 3-chloro-2-nitroaniline market globally
[150 Pages Report] Check for Discount on 2016 Global and Chinese 2-Methyl-4-Nitroaniline Industry Market Research Report report by Prof Research. The Global and Chinese 2-Methyl-4-Nitroaniline Industry, 2011-...
... aims at providing comprehensive data on 4-methoxy-n-methyl-2-nitroaniline
Unscramble aniline, Unscramble letters aniline, Point value for aniline, Word Decoder for aniline, Word generator using the letters aniline, Word Solver aniline, Possible Scrabble words with aniline, Anagram of aniline
Aniline dioxygenase is a multicomponent Rieske nonheme-iron dioxygenase enzyme isolated from Acinetobacter sp. strain YAA. Saturation mutagenesis of the substrate-binding pocket residues, which were identified using a homology model of the α subunit of the terminal dioxygenase (AtdA3), was used to probe the molecular determinants of AtdA substrate specificity. The V205A mutation widened the substrate specificity of aniline dioxygenase to include 2-isopropylaniline, for which the wild-type enzyme has no activity. The V205A mutation also made 2-isopropylaniline a better substrate for the enzyme than 2,4-dimethylaniline, a native substrate of the wild-type enzyme. The I248L mutation improved the activity of aniline dioxygenase against aniline and 2,4-dimethylaniline approximately 1.7-fold and 2.1-fold, respectively. Thus, it is shown that the α subunit of the terminal dioxygenase indeed plays a part in the substrate specificity as well as the activity of aniline dioxygenase. Interestingly, the ...
Aniline dioxygenase is a multicomponent Rieske nonheme-iron dioxygenase enzyme isolated from Acinetobacter sp. strain YAA. Saturation mutagenesis of the substrate-binding pocket residues, which were identified using a homology model of the α subunit of the terminal dioxygenase (AtdA3), was used to probe the molecular determinants of AtdA substrate specificity. The V205A mutation widened the substrate specificity of aniline dioxygenase to include 2-isopropylaniline, for which the wild-type enzyme has no activity. The V205A mutation also made 2-isopropylaniline a better substrate for the enzyme than 2,4-dimethylaniline, a native substrate of the wild-type enzyme. The I248L mutation improved the activity of aniline dioxygenase against aniline and 2,4-dimethylaniline approximately 1.7-fold and 2.1-fold, respectively. Thus, it is shown that the α subunit of the terminal dioxygenase indeed plays a part in the substrate specificity as well as the activity of aniline dioxygenase. Interestingly, the ...
chemBlink provides information about CAS # 21731-56-6, 4-(Methylsulfonyl)-2-nitroaniline, 4-Amino-3-nitrophenyl methyl sulfone, molecular formula: C7H8N2O4S.
Creative-Proteomics offer cas 99-30-9 2,6-DICHLORO-4-NITROANILINE (RING-13C6, 99%) (DICHLORAN). We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Polymeric compositions are disclosed comprising protonated, electrically conducting polyaniline; cyclic organic compounds capable of forming ring-ring interactions with the six-membered rings of the polyaniline and hydrogen bonding with the NH groups of the polyaniline; and anionic surface active additives. According to the invention, no particular requirements are posed for the counter-ions of polyaniline, which allows for the use of non-functionilized counter-ions. The conducting polyaniline complexes of the invention are processible in the fluid-phase and exhibit significantly improved electrical properties.
CH421 Experiment 2 Nitration of Aniline: a three-step protecting group strategy to prepare p-nitroaniline Reading: Organic Chemistry by John McMurry, 8e, Chapter Techniques: recrystallization,
We,China N-Methyl Aniline 100-61-8 Suppliers and China N-Methyl Aniline 100-61-8 Manufacturers, provide N-Methyl Aniline 100-61-8 product and the products related with China N-Methyl Aniline 100-61-8 - Yangshi Chemica
By Rik Ossenkoppele, Niels D. Prins, Yolande A.L. Pijnenburg, Afina W. Lemstra, Wiesje M. van der Flier, Sofie F. Adriaanse, Albert D. Windhorst, Ron L.H. Handels, Claire A.G. Wolfs, Pauline Aalten, Frans R.J. Verhey, Marcel M. Verbeek, Mark A. van Buchem, Otto S. Hoekstra, Adriaan A. Lammertsma, Philip Scheltens, Bart N.M. van Berckel Abstract: Background: [11C]Pittsburgh compound B ([11C]PIB) and [18F]-2-fluoro-2-deoxy-D-glucose ([18F]FDG) PET measure fibrillar amyloid-β load and glucose metabolism, respectively. We evaluated the impact of these tracers on the diagnostic process in a memory clinic population.Methods: One hundred fifty-four patients underwent paired dynamic [11C]PIB and static [18F]FDG PET scans shortly after completing Read & Research Alzheimers More. ...
Radiotracer development activities within the PET Facility focus primarily on neuroscience applications, with an emphasis on in vivo imaging of neurodegenerative disease pathology. Since its inception in 1992, Dr. Chester Mathis, Director of the PET Facility and Senior Radiochemist, has led these efforts. A long-standing collaboration with the laboratory of Dr. William E. Klunk, Dept. of Psychiatry, yielded the first successful PET imaging agent for imaging beta-amyloid (Aβ) plaques, an abnormal protein aggregate that is one of the pathologic hallmarks of Alzheimers Disease (AD). This agent, [11C]Pittsburgh Compound B (or [11C]PiB), continues to be an important investigational tool used worldwide in human AD research. A radiofluorinated analog of PiB developed by the PET Facility is under license to GE Healthcare, which is marketed as Vizamyl™ and approved by the U.S. FDA for clinical use. Currently, efforts in this area of research are focused on the development and application of PET ...
Aniline Compounds are organic compounds, consisting of a phenyl group attached to an amine group, with a molecular formula (C6H5NH2)
Search Indian Aniline Oil Manufacturers and Suppliers Details - Contact to Aniline Oil Exporters in India, Aniline Oil Wholesalers, Aniline Oil Distributors and Traders from India.
Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane. Like most volatile amines, it possesses the somewhat unpleasant odour of rotten fish. It ignites readily, burning with a smoky flame characteristic of aromatic compounds. Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
HOPA = Hemalaun, Orange G, Phosphormolybdenic acid, Aniline blue Cell nuclei are stained with hemalaun or Weigerts iron-hematoxylin and then counterstained with a dye mixture of orange-phosphormolybden with aniline blue.. ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Visit ChemicalBook To find more Aniline(62-53-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Aniline(62-53-3). At last,Aniline(62-53-3) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
Latest China HS Code & tariff for n dimethyl aniline - Tariff & duty, regulations & restrictions, landed cost calculator, customs data for n dimethyl aniline in ETCN. China customs statistics trade data.
Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (between 15% and 30% (w/w)) of high molecular weight ((Mw)|120,000, and (Mn)|30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects,
Protein expression of CDK1 and p-CDK1 in rat spleens.(A) Western blot determination of CDK1 and p-CDK1 protein expression in control and aniline-treated rats. (
Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkins Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others. Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of lymphomas and other types of cancer. It blocks some of the enzymes that keep cancer cells from dying.
... Other names PhenylamineAminobenzeneBenzenamine Identifiers CAS number 62-53-3 SMILES NC1=CC=CC=C1 Properties Molecular formula C6H7N Molar mass
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for BENZENAMINE, 2-FLUORO-4-METHYL-, HYDROBROMIDE (CAS No. 874186-81-9)
21889-05-4 - BBYJHUAEFSHMHU-UHFFFAOYSA-N - Benzenamine, 4-(1H-indol-2-yl)- (9CI) - Similar structures search, synonyms, formulas, resource links, and other chemical information.
32971-60-1 - BZOLKXGJNJUPQQ-SAPNQHFASA-N - Benzenamine, 3,4-dichloro-N-(1-(2-propenyl)-2-piperidinylidene)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Searching for two-dimensional (2D) layered materials with diverse electronic conductivities is one of the leading topics in materials science. Herein, from first-principles calculations, we report the thickness-dependent conductivity of layered 2D polyaniline (PANI) structures. When PANI is thinned down to a
Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2020 Elsevier B.V "We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies. Log in to Pure. ...
Page contains details about polyaniline nanotube film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
A method is provided for the preparation of a conductive composition containing a polymerized aromatic amine wherein the aromatic amine is oxidatively polymerized in an acidic aqueous medium in the presence of an oxidizing agent, a doping agent and an aromatic polyalkyleneoxide in an amount sufficient to stabilize the resulting composition. Preferably, the aromatic amine is aniline or a substituted aniline. Compositions produced by such method are also disclosed. These compositions are useful for treating various substrates to make such substrates conductive.
Name: 2-Chloro-4-nitrobenzenamine CA Name: Benzenamine,2-chloro-4-nitro- Molecular Structure: 2-Chloro-4-nitrobenzenamine,Benzenamine,2-chloro-4-nitro-,CAS 121-87-9,172.57,C6H5ClN2O2 2-Chloro-4-nitrobenzenamine,Benzenamine,2-chloro-4-nitro-,CAS 121-87-9,172.57,C6H5ClN2O2 Molecular Formula:C6H5ClN2O2 Molecular Weight: 172.57 CAS Registry Number: 121-87-9
S-2765, which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm. Packaging 10mg Price US$68
This dose-escalating study is to determine the safety, pharmacokinetics, and preliminary efficacy of venetoclax in combination with navitoclax and chemotherapy
N-cyclopropyl-2-nitro-5-[4-(4-phenyl-1,3-thiazol-2-yl)piperazin-1-yl]aniline; CAS Number: ; find Princeton BioMolecular Research, Inc.-PRIH93ED878D MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich
Structure, properties, spectra, suppliers and links for: 4-(8-Methyl-8,9-dihydro-7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline.
Gentaur molecular products has all kinds of products like :search , Nacala \ Aniline \ 02915-25 for more molecular products just contact us
Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, ONeil JP, Huang Y, Miller BL, Jagust WJ, Rabinovici GD. Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients ...
This site lists all substances and their properties which are reported on in the indexed Landolt-Börnstein volumes. In total, 160 000 organic and inorganic compounds are described by names, molecular structures, chemical abstract numbers and other identifiers. Properties are directly linked to the full documents at Springerlink. Landolt-Börnstein citations are given as "Vol. LB-Group/Volume Chapter: number [, page]: document title" and have a hyperlink to the full-text of the document containing the substance. The short identifier of the LB volume leads to a complete denotation of the reference with a direct link to the respective volume. For several compounds crosslinks to some derivatives are provided, e.g. isotope-marked compounds, hydrates and hydrochlorides. For benzenamine (aniline) for example there is a direct link to the related compounds benzenamine-d7 and aniline hydrochloride/hydrobromide/hydroiodide. Additionally, EINECS numbers (European Inventory of Existing Commercial Chemical ...
4BC6: Crystal Structure of Human Serine Threonine Kinase- 10 Bound to Novel Bosutinib Isoform 1, Previously Thought to be Bosutinib
4BC6: Crystal Structure of Human Serine Threonine Kinase- 10 Bound to Novel Bosutinib Isoform 1, Previously Thought to be Bosutinib
L. Hebbard, G. Cecena, J. Golas, J. Sawada, L. G. Ellies, A. Charbono, R. Williams, R. E. Jimenez, M. Wankell, K. T. Arndt, S. Q. Dejoy, R. A. Rollins, V. Diesl, M. Follettie, L. Chen, E. Rosfjord, Robert Cardiff, M. Komatsu, F. Boschelli, R. G. Oshima ...
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Cas Index,Name Index,APIs,Pharmaceutical intermediates,Fine chemicals,Browse by Compound Class,Browse by Functional Group,27652-89-7,,Capot Chimique
Zhejiang Weihua Chemical Co.,Ltd. is specialized in technology development, chemical manufacturer and trading. Our main products are benzotrifluoride series, total capacity is about 18000mt per year. Including p-chlorobenzotrifluoride is 10000mt annually, 3,4-Dichlorobenzotrifluoride 3000mt annually, etc.
Notable examples include: The production of aniline compounds. General oxidizing agent. Victor Meyer type nucleophilic ... Silver nitrite is an inorganic compound with the formula AgNO2. Silver nitrite has many applications. ... substitution reactions with organobromides or organoiodides forming nitro compounds. Nitroalkene synthesis with nitryl iodide ...
Aniline derivatives are converted to a diazo compounds. In years following the work Baudisch and Cronheim did, Konecny and ...
... bladder cancer in dye workers exposed to aniline compounds; and leukemia and lymphoma in chemical workers exposed to benzene. ...
Aniline 5 is converted to compound 6, in three steps; conversion to an ortho-aminothiol through the Herz-reaction (aniline 5 ... In a last step the nitrile is hydrolysed resulting in 6. This compound is converted to 7 via a ring-closing reaction and ... The compound, (thioindoxyl, 7) is an important intermediate in the organic synthesis of some dyes. Condensation with ... The Herz reaction, named after the chemist Richard Herz, is the chemical conversion of an aniline-derivative (1) to a so-called ...
The three compounds seriously discussed are ethylene, aniline, and dinitrophenol. Even at low levels these organic chemical ... Organic Air Pollutants: This is similar to the general stress hypothesis, but focuses on organic compounds. ... such as acid rain and organic compounds, and drought. Diseases and pests can kill large groups of trees very easily, but the ... compounds have caused: abnormal dropping of foliage, twisted foliage, and killing of seedlings. This is proposed by Fritz Führ ...
Reduction of this nitro compound affords the aniline. Sulfonation with oleum gives 4-amino-5-methoxy-2-methylbenzenesulfonic ... The compound features both amine and methoxy functional groups. It is used as an intermediate in preparation of dyes and ... The compound is obtained in several steps from 4-chlorotoluene. Nitration gives mainly 3-nitro-4-chlorotoluene, which reacts ... para-Cresidine is an organic compound with the formula CH3OC6H3(CH3)NH2. It is a white solid that is soluble in organic ...
The resulting nitro compound is reduced to the aniline. Trimethylaniline is a building block to a variety of bulky ligands. ... Gerald Booth "Nitro Compounds, Aromatic" in "Ullmann's Encyclopedia of Industrial Chemistry" 2007; Wiley-VCH, Weinheim. doi: ... 2,4,6-Trimethylaniline is a organic compound with formula (CH3)3C6H2NH2. It is an aromatic amine that is of commercial interest ... N-heterocyclic carbenes, as found in 2nd generation Grubbs' catalyst, are also prepared from this compound. ...
Most derivatives of aniline are prepared via nitration of aromatic compounds followed by reduction. Nitrations entail combining ... The pure compound is colorless, but older samples tend to acquire a yellow cast due to decomposition into oxides of nitrogen ... In elemental analysis by ICP-MS, ICP-AES, GFAA, and Flame AA, dilute nitric acid (0.5 to 5.0%) is used as a matrix compound for ... Nitration of organic compounds with nitric acid is the primary method of synthesis of many common explosives, such as ...
The compound is a derivative of aniline, consisting of an amine bound to two phenyl groups. The compound is a colorless solid, ... T. Kahl, K.-W. Schröder, F. R. Lawrence, W. J. Marshall, Hartmut Höke, Rudolf Jäckh, "Aniline" in Ullmann's Encyclopedia of ... Diphenylamine is manufactured by the thermal deamination of aniline over oxide catalysts: 2 C6H5NH2 → (C6H5)2NH + NH3 It is a ... Diphenylamine is an organic compound with the formula (C6H5)2NH. ... reflecting the antioxidant nature of aniline derivatives. Some ...
Some electron-rich organic compounds (e.g., aniline) also are oxidized at low potentials, but only irreversibly. Oxidation of ... Such organometallic compounds are also known as sandwich compounds. The rapid growth of organometallic chemistry is often ... This compound on boiling under reflux in benzene is converted to ferrocene. Because of the ease of substitution, many ... The strained compounds undergo ring-opening polymerization. Many phosphine derivatives of ferrocenes are known and some are ...
Polymerization of substituted anilines, phenols, and heterocyclic compounds by peroxidase in organic solvents. Columbus, Ohio: ... On the other hand, for an enzyme such as cytochrome c peroxidase, the compounds that donate electrons are very specific, due to ... Other studies have shown that peroxidases may be used successfully to polymerize anilines and phenols in organic solvent ... For example, horseradish peroxidase can use a variety of organic compounds as electron donors and acceptors. Horseradish ...
N,N-Dimethylaniline (DMA) is an organic chemical compound, a substituted derivative of aniline. It consists of a tertiary amine ... DMA is also used as a precursor to other organic compounds. A study of the in vitro metabolism of N,N-dimethylaniline using ... 2007) "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry. John Wiley & Sons: New York. doi:10.1002/14356007.a02_303 ... DMA was first reported in 1850 by the German chemist A. W. Hofmann, who prepared it by heating aniline and iodomethane: C6H5NH2 ...
The compound is obtained by azo coupling of aniline and acetoacetanilide or their derivatives. The class of compounds was ... Arylide yellow, also known as Hansa yellow and monoazo yellow, are a family of organic compounds used as pigments. They are ... and aniline (acetoacetanilide precursor) to produce medium yellows. Pigment Yellow 3 (CAS# 6486-23-3), derived from 4-chloro-2- ...
... is a compound where an aniline molecule is substituted with a bromine atom. Commercially available, this ... "Studies on analgesics of aniline series. I. Preparation and properties of beta-alaninamide series". Chem Pharm Bull. 13: 198- ... compound may be used as a building block, e.g. in the preparation of p-bromobiphenyl via the Gomberg-Bachmann reaction. In the ...
... (1,2-diphenylhydrazine) is an aromatic organic compound consisting of two aniline groups joined via their ...
... is a mild methylating agent, useful for dimethylation of anilines and related heterocyclic compounds. The ... It has some specialized uses in the production of other compounds. Trimethyl phosphate is prepared by treating phosphorus ... Collective Volume, 5, p. 1085 J. Svara, N. Weferling, T. Hofmann "Phosphorus Compounds, Organic" in Ullmann's Encyclopedia of ...
The coupler compounds (couplers) are meta-substituted derivatives of aniline. They come in three major classes based on the ... 2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ... These compounds produce broad-band absorption when they react to form dyes, allowing for more natural-looking hair colors. The ...
The Doebner-Miller reaction is the organic reaction of an aniline with α,β-unsaturated carbonyl compounds to form quinolines. ... Bergström, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... β-unsaturated carbonyl compound is prepared in situ from two carbonyl compounds (via an Aldol condensation), the reaction is ... elimination of one aniline molecule through 8 and rearomatization leads to final product 9. Because α-amino protons are not ...
Electron-rich aromatic compounds, such as phenols, anilines, and various aromatic heterocycles, can be brominated using NBS. ... Side reactions include the formation of α-bromoketones and dibromo compounds. These can be minimized by the use of freshly ... Collective Volume, 6, p. 190 Stotter, P. L.; Hill, K. A. (1973). "α-Halocarbonyl compounds. II. Position-specific preparation ... Collective Volume, 10, p. 128 Djerassi, Carl (1948). "Brominations with N-Bromosuccinimide and Related Compounds. The Wohl- ...
... is a chemical compound which is the amide of salicylic acid and aniline. It is classified as both a salicylamide ...
... s are chemical compounds which consist of an aniline ring substituted with two chlorine atoms and have the ... As aniline derivatives, they are named with the amino group in position 1. They are all colorless, although commercial samples ... Thomas Kahl, Kai-Wilfrid Schröder, F. R. Lawrence, W. J. Marshall, Hartmut Höke, Rudolf Jäckh "Aniline" in Ullmann's ...
... is an organic compound with the formula CH3C(O)CH2C(O)NHC6H5. It is the acetoacetamide derivative of aniline. ... It and many related compounds (prepared from various aniline derivatives) are used in the production of organic pigments called ... Acetoacetanilide is prepared by acetoacetylation of aniline using diketene. To make the dyes, acetoacetanilides are coupled to ...
Aromatic nitriles are often prepared in the laboratory from the aniline via diazonium compounds. This is the Sandmeyer reaction ... Organic compounds containing multiple nitrile groups are known as cyanocarbons. Inorganic compounds containing the −C≡N group ... The first compound of the homolog row of nitriles, the nitrile of formic acid, hydrogen cyanide was first synthesized by C. W. ... A nitrile is any organic compound that has a −C≡N functional group. The prefix cyano- is used interchangeably with the term ...
... (NMA) is an aniline derivative. It is an organic compound with the chemical formula C6H5NH(CH3). The substance ... Chemicals, such as methylal, aniline-type compounds, halogens and those containing phosphorus and silicon, etc. should not ... "Monomethyl aniline". Immediately Dangerous to Life and Health Concentrations (IDLH). National Institute for Occupational Safety ...
The Bechamp reduction is used to reduce aromatic nitro compounds to their corresponding anilines, using iron and hydrochloric ... Tertiary aliphatic nitro compounds, however, are converted in good yield to the amine compound using the Bechamp reduction. Org ... The Bechamp reaction is broadly applicable to aromatic nitro compounds. Aliphatic nitro compounds are more difficult to reduce ... This reaction was originally used to produce large amounts of aniline for industry, but catalytic hydrogenation is the ...
... compound F. Compound F continues to react with the palladium intermediate B, with regeneration of the copper halide, G. ... This coupling can be carried out starting from anilines by formation of the diazonium salt followed by in situ Sonogashira ... The active palladium catalyst is the 14 electron compound Pd0L2, complex A, which reacts with the aryl or vinyl halide in an ... In an inverse Sonogashira coupling the reactants are an aryl or vinyl compound and an alkynyl halide. While a copper co- ...
... and concrete surfaces contaminated with amine compounds (aniline) w... ... Aniline) by DeconGel 1101. AbstractSurface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, ... No comments were found for Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101. Be the first to comment! ... Aniline was chosen as a representative amine compounds (industrial plastics feedstock); DeconGel is expected to have similar ...
benzenetetraamine promotes the reaction [[Plant Extracts results in increased negative regulation of extracellular matrix disassembly] which results in increased negative regulation of cell motility ...
... and the properties of the title compounds are described. Analytical conductometric, spectral (infrared and ultraviolet) and ... Etherate, pyridine, and aniline compounds of the complex tri- and tetra-iodoacids of Zn(II) and Cd(II). ... The existence of metal-nitrogen bond for all pyridine and aniline complexes, except H2CdI4·4An (An=aniline), is adduced from ... The preparation, for the first time, and the properties of the title compounds are described. Analytical conductometric, ...
Title: Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds. ... "Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds". Germany. doi:10.1002/ ... title = {Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds},. author = { ... Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds ...
It is observed in these compounds case as in other LC compounds Vuks isotropic model is favored compared to that of anisotropic ... p-n-alkoxy anilines, 2O.Om with m = 3 to 10 liquid crystalline compounds except with m = 5 which has been already published. ... The rest of the compounds exhibit the nematic LC phase except with m = 10 which shows the smectic-C phase along the nematic ... nO.m and nO.Om compounds play an important role in the fundamental and applied aspects. As a part of our systematic studies of ...
... B. J. Aylett, M. J. Hakim*Journal of the Chemical Society ...
... aniline Precursor products, 3-(Trifluoromethylthio)aniline Downstream products ect. ... Current Page: Home › Chemical Dictionary › 369-68-6 › 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Products ... 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Downstream Products Precursor:. 404-74-0 79576-16-2 370-47-8 90109-81-2 ...
Book; Format: print Publisher: London : Monitoring and Assessment Research Centre, 1986Availability: Items available for loan: WHO HQ [Call number: QV 632 86HE] (1). Withdrawn (1). ...
Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101 Abstract Surface decontamination efficacy determination ... Surface Decontamination of Cadmium Compounds (Cadmium Chloride (CdCl2) and Cadmium Oxide (CdO)) by DeconGel 1101 OBJECTIVE The ... Surface Decontamination of Cyanide Compounds (Potassium Ferricyanide (K3[Fe(CN)6])) by DeconGel 1101 ABSTRACT Surface ... Surface Decontamination of Tin compounds (tributyltin chloride) by DeconGel 1101 Abstract Surface decontamination efficacy of ...
Vilesov, F.I.; Terenin, A.N., The photoionization of the vapors of certain organic compounds, Dokl. Akad. Nauk SSSR, 1957, 115 ... Meek, J.T.; Sekreta, E.; Wilson, W.; Viswanathan, K.S.; Reilly, J.P., The laser photoelectron spectrum of gas phase aniline, J ... Palmer, M.H.; Moyes, W.; Spiers, M.; Ridyard, J.N.A., The electronic structure of substituted benzenes; a study of aniline, the ... Smith, M.A.; Hager, J.W.; Wallace, S.C., Two color photoionization spectroscopy of jet cooled aniline: Vibrational frequencies ...
Aniline Compounds are organic compounds, consisting of a phenyl group attached to an amine group, with a molecular formula ( ... Aniline and substituted Anilines Compounds. "Aniline Compounds (aminobenzenes)" Aniline and substituted Anilines Compounds. In ... Aniline Compounds. In organic chemistry, Aniline Compounds, as organic compounds, consisting of a phenyl group attached to an ... As an aniline compound, Anilides are any aromatic amides obtained by acylation of aniline. Examples of anilide compounds ...
... bladder cancer in dye workers exposed to aniline compounds; leukemia and lymphoma in chemical workers exposed to benzene; ... more quickly after the introduction of new chemical compounds, and in more severe forms. ...
What is the IUPAC name for the compound a. aminobenzene b. benzoamine c. aniline d. no correct response. Organic And Biological ... A chemical bond is formed due to the attraction between the atoms that lead to the formation of a compound or a molecule. ...
Aniline Compounds * Stilbenes * 4-(N-methylamino)-4-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene ...
Aniline Compounds / administration & dosage* * Aniline Compounds / adverse effects * Aniline Compounds / pharmacokinetics * ...
0 (AKB-9778); 0 (Angiopoietin-1); 0 (Angiopoietin-2); 0 (Aniline Compounds); 0 (Sulfonic Acids); 0 (Vascular Endothelial Growth ...
0/Aniline Compounds; 0/Ferric Compounds; 0/Manganese Compounds; 0/Polychlorinated Biphenyls; 0/Silicates; 0/Soil; 0/Soil ... Aniline Compounds / chemistry*. Catalysis. Environmental Pollution / prevention & control. Ferric Compounds. Ferritins / ... Manganese Compounds / chemistry. Pentachlorophenol / chemistry*. Polychlorinated Biphenyls / chemistry*. Silicates / chemistry ... The efficiency of the mechanochemical removal was compared with batch experiments for the soluble compounds (PCP and 4-CA). The ...
0 (2-nitroaniline); 0 (Aniline Compounds); 0 (Environmental Pollutants); 0 (Reducing Agents). ... Though multiple oxidizing compounds such as hydrogen peroxide are widely recognized as mediators and inducers of oxidative ... In the present work, we demonstrate how this problem can be circumvented by selectively oxidizing offending compounds by ...
Notable examples include: The production of aniline compounds. General oxidizing agent. Victor Meyer type nucleophilic ... Silver nitrite is an inorganic compound with the formula AgNO2. Silver nitrite has many applications. ... substitution reactions with organobromides or organoiodides forming nitro compounds. Nitroalkene synthesis with nitryl iodide ...
Aniline derivatives are converted to a diazo compounds. In years following the work Baudisch and Cronheim did, Konecny and ...
JavaScript is disabled for your browser. Some features of this site may not work without it ...
Aniline Compounds [‎1]‎. Anniversaries and Special Events [‎2]‎. Anopheles [‎2]‎. Antarctic Regions [‎1]‎. ...
9.2.2.10.5. 2.2.10.5 Aniline Compounds. 9.2.2.10.6. 2.2.10.6 Azides ...
NIOSH-Author; Carcinogens; Anilines; Chlorine-compounds; Amines; Protein-biochemistry; Oxidative-phosphorylation; Arylamines ...
NIOSH-Author; In-vivo-studies; Laboratory-animals; Anilines; Organo-chlorine-compounds; Chemical-binding; Nucleic-acids; ...
  • 9 Generally, studies on ferrocene revolve around generation of compounds that are used in materials science, 10 electrochemistry 11,12 catalysis, 13-15 medicinal applications 16-24 and nonlinear optics 25,26 amongst others. (scielo.org.za)
  • Only recently, have sp 2 -hybridized phosphorus compounds been utilized as ligands for transition metals in catalysis. (yorku.ca)
  • Surface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, aluminum, and concrete surfaces contaminated with amine compounds (aniline) was performed using GC/MS (Gas Chromatography/Mass Spectrometry) according to Environmental Protection Agency (EPA) SW-846 Methods: 3500C (Sampling) and 8270C (Analysis). (environmental-expert.com)
  • Optimized experimental and analytical methods were successfully developed following standardized EPA sampling and analysis methods as guidelines for determination of organic compounds dissolved in a suitable solvent able to completely solvate aniline as well as DeconGel components. (environmental-expert.com)
  • Methods to predict the hydrolysis rates of organic compounds for use in the environmental assessment of pollutants have not advanced significantly since the early 80s of the 20th century. (europa.eu)
  • To develop such predictive methods, one needs a set of rate constants for a series of compounds that have systematic variations in structure and a database of molecular descriptors related to the substituents on the reactant molecule. (europa.eu)
  • Ketoamine compounds and related methods for reactivation of tumor suppressor protein p53. (sumobrain.com)
  • This invention relates to aniline derived non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of suc. (sumobrain.com)
  • Laboratory experience to complement Organic Chemistry I. Techniques explored include methods for separation, purification and identification of organic compounds, and syntheses. (uwosh.edu)
  • The oligomers are prepared by reacting tetraamines, diaminodiols, or diaminothiols (i.e. four-functional compounds) with poly-carboxylic acid halides, and crosslinking phenylimide end cap monomers in a suitable solvent under an inert atmosphere. (google.es)
  • NHFG compounds are those that do not have any heteroatoms that can undergo hydrolysis over the pH range of 5 to 9 at 25 °C. Examples include xylenes, carboxylic acids, and polycyclic aromatic hydrocarbons (PAHs), 2. (europa.eu)
  • This compound group is defined by the SMILES string '[Rh]' and subsequently filtered to remove substances containing '[C]'. For more information on SMILES, see https://en.wikipedia.org/wiki/Simplified_molecular-input_line-entry_system . (pharosproject.net)
  • and although he was mainly concerned with the structure of cholesterol, he investigated many other sterols and established the membership of these substances in a group that he called the "sterines," In 1908 Windaus found that cholesterol formed an insoluble compound with digitonin. (encyclopedia.com)
  • and among the derivatives of these substances he had prepared a compound that he called cholanic acid. (encyclopedia.com)
  • In organic chemistry, Aniline Compounds , as organic compounds , consisting of a phenyl group attached to an amine group, with a molecular formula (C 6 H 5 NH 2 ). (wellnessadvocate.com)
  • I want to get the latest chemistry news from C&EN in my inbox every week. (acs.org)
  • He was particularly struck by the physiological applications of Fischer's work and began to develop what later became the basis for his approach to chemistry, an interest in the general physiological mechanisms of the compounds he studied. (encyclopedia.com)
  • The oxidation of aniline has been carefully investigated. (bionity.com)
  • An EC mechanism for electrooxidation of N- substituted anilines based by in situ UV-Vis spectroelectroscopy had been proposed [ 5 - 8 ], and based on this mechanism it had been reported that the formation of primary radical cation is the rate-limiting step in electrochemical oxidation of aniline. (hindawi.com)
  • Biodegradation of aniline in an alkaline environment by a novel strain of the halophilic bacterium, Dietzia natronolimnaea JQ-AN. (semanticscholar.org)
  • These chelating ligands form catalytically active complexes with Pd and Pt and can efficiently be utilized in the hydroamination of 1,3-dienes, the dehydrosilation of ketones, and the allylation of aniline or C-activated methylene compounds. (yorku.ca)
  • Monomethyl and dimethyl aniline are colourless liquids prepared by heating aniline, aniline hydro-chloride and methyl alcohol in an autoclave at 220 °C. They are of great importance in the colour industry. (bionity.com)
  • It is therefore essential to determine appropriate concentrations of mitigating sorbents to render a Headspace Test based on carbon analysis suitable to determine ready biodegradability of compounds which might inhibit inoculum. (americanelements.com)
  • Organic compounds are, at the most basic level, compounds that contain carbon and hydrogen. (fishersci.com)
  • Because of the almost infinite number of ways in which carbon can bond with carbon and other elements, it's no surprise that about 95 percent of the millions of known compounds are organics with highly diverse structures. (fishersci.com)
  • This analogy is based upon the fact that phosphorus and carbon exhibit almost similar electron acceptor and electron donor abilities allowing such phosphorus compounds to be utilized instead of genuine carbon species. (yorku.ca)