A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.
Alkylating anti-neoplastic agent.
Phenols substituted in any position by an amino group.
Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.
Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.
A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
A sympathomimetic agent with properties similar to DEXTROAMPHETAMINE. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222)
The creation of an amine. It can be produced by the addition of an amino group to an organic compound or reduction of a nitro group.
A genus of gram-negative, strictly aerobic chemoorganotrophic bacteria, in the family COMAMONADACEAE.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
A barbiturate that is effective as a hypnotic and sedative.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A species of gram-negative rod-shaped bacteria found ubiquitously and formerly called Comamonas acidovorans and Pseudomonas acidovorans. It is the type species of the genus DELFTIA.
Inorganic or organic compounds that contain sulfur as an integral part of the molecule.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
A chlorinated anilide that is used as an herbicide.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation.
A narcotic analgesic and antitussive. It is metabolized in the liver by ETHYLMORPHINE-N-DEMETHYLASE and used as an indicator of liver function.
A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
Substances or organisms which pollute the water or bodies of water. Use for water pollutants in general or those for which there is no specific heading.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The reaction of two molecular entities via oxidation usually catalyzed by a transition metal compound and involving dioxygen as the oxidant.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Oxidases that specifically introduce DIOXYGEN-derived oxygen atoms into a variety of organic molecules.
The rate dynamics in chemical or physical systems.
The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A genus of gram-negative bacteria of the family MORAXELLACEAE, found in soil and water and of uncertain pathogenicity.
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.
A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.
An azo dye with carcinogenic properties.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Nitrogen mustard analog of quinacrine used primarily as a stain in the studies of chromosomes and chromatin. Fluoresces by reaction with nucleic acids in chromosomes.
The removal of contaminating material, such as radioactive materials, biological materials, or CHEMICAL WARFARE AGENTS, from a person or object.
Elements, compounds, mixtures, or solutions that are considered severely harmful to human health and the environment. They include substances that are toxic, corrosive, flammable, or explosive.
Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
A purine base found in most body tissues and fluids, certain plants, and some urinary calculi. It is an intermediate in the degradation of adenosine monophosphate to uric acid, being formed by oxidation of hypoxanthine. The methylated xanthine compounds caffeine, theobromine, and theophylline and their derivatives are used in medicine for their bronchodilator effects. (Dorland, 28th ed)
The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.

Relationship between L-type Ca2+ current and unitary sarcoplasmic reticulum Ca2+ release events in rat ventricular myocytes. (1/1809)

1. The time courses of Ca2+ current and Ca2+ spark occurrence were determined in single rat ventricular myocytes voltage clamped with patch pipettes containing 0.1 microM fluo-3. Acquisition of line-scan images on a laser scanning confocal microscope was synchronized with measurement of Cd2+-sensitive Ca2+ currents. In most cells, individual Ca2+ sparks were observed by reducing Ca2+ current density with nifedipine (0.1-8 microM). 2. Ca2+ sparks elicited by depolarizing voltage-clamp pulses had a peak [Ca2+] amplitude of 289 +/- 3 nM with a decay half-time of 20.8 +/- 0.2 ms and a full width at half-maximum of 1.40 +/- 0.03 microm (mean +/- s. e.m., n = 345), independent of the membrane potential. 3. The time between the beginning of a depolarization and the initiation of each Ca2+ spark was calculated and data were pooled to construct waiting time histograms. Exponential functions were fitted to these histograms and to the decaying phase of the Ca2+ current. This analysis showed that the time constants describing Ca2+ current and Ca2+ spark occurrence at membrane potentials between -30 mV and +30 mV were not significantly different. At +50 mV, in the absence of nifedipine, the time constant describing Ca2+ spark occurrence was significantly larger than the time constant of the Ca2+ current. 4. A simple model is developed using Poisson statistics to relate macroscopic Ca2+ current to the opening of single L-type Ca2+ channels at the dyad junction and to the time course of Ca2+ spark occurrence. The model suggests that the time courses of macroscopic Ca2+ current and Ca2+ spark occurrence should be closely related when opening of a single L-type Ca2+ channel initiates a Ca2+ spark. By comparison with the data, the model suggests that Ca2+ sparks are initiated by the opening of a single L-type Ca2+ channel at all membrane potentials encountered during an action potential.  (+info)

RSR13, an allosteric effector of haemoglobin, and carbogen radiosensitize FSAII and SCCVII tumours in C3H mice. (2/1809)

Pre-clinical evaluation has demonstrated that 2-[4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy]-2-methylpropi onic acid (RSR13) acts as an allosteric effector of haemoglobin (Hb). RSR13 binding to Hb results in decreased haemoglobin-oxygen (Hb-O2) affinity, improved tumour oxygenation, and enhanced radiation-induced cell killing in several experimental tumour systems. In the present work, ex vivo clonogenic survival analyses are applied in two murine tumour systems to characterize the relationship between the magnitude of decrease in Hb-O2 affinity and radiosensitization, the influence of inspired pO2 upon this effect, and the efficacy of combining RSR13 and radiation during a course of repeated radiation exposures. For FSaII tumours in C3H mice breathing air, 100 mg kg(-1) RSR13 administered intraperitoneally produced an enhancement ratio (ER) of 1.3, but there was marked desensitization at a RSR13 dose of 300 mg kg(-1) (ER 0.6). The most likely reason for the increased radioresistance was insufficient oxygen loading of Hb in the pulmonary circulation due to reduced haemoglobin-oxygen affinity because carbogen breathing combined with 300 mg kg(-1) RSR13 reversed the effect and produced an ER of 1.8. In SCCVII tumours in C3H mice irradiated with eight fractions of 2.5 Gy over 4 days, the surviving fraction was reduced to 58-67% of control values when RSR13 was combined with radiation on days 1 and 2, days 3 and 4, or days 1-4. These results confirm that combining RSR13 and irradiation within a fractionated course of clinically relevant low-dose exposures provides significant radiosensitization. Additional preclinical experimentation is needed to define better the optimum dose-scheduling conditions for clinical applications.  (+info)

Preservation of canine myocardial high-energy phosphates during low-flow ischemia with modification of hemoglobin-oxygen affinity. (3/1809)

Conventional approaches for the treatment of myocardial ischemia increase coronary blood flow or reduce myocardial demand. To determine whether a rightward shift in the hemoglobin-oxygen saturation curve would reduce the metabolic and contractile effects of a myocardial oxygen-supply imbalance, we studied the impact of a potent synthetic allosteric modifier of hemoglobin-oxygen affinity, a 2-[4-[[(3,5-disubstituted anilino)carbonyl]methyl] phenoxy] -2-methylproprionic acid derivative (RSR13), during low-flow ischemia. Changes in myocardial high-energy phosphate levels and pH were studied by 31P nuclear magnetic resonance (NMR) spectroscopy in 12 open-chest dogs randomized to receive RSR13 or vehicle control during a reversible reduction of left anterior descending (LAD) coronary artery blood flow. Changes in cardiac metabolites and regional ventricular function studied by pressure segment-length relations were also investigated in additional animals before and after RSR13 administration during low-flow LAD ischemia. The intravenous administration of RSR13 before ischemia resulted in a substantial increase in the mean hemoglobin p50 and attenuated the decline in cardiac creatine phosphate/adenosine triphosphate (PCr/ATP), percent PCr, and pH during ischemia without a change in regional myocardial blood flow, heart rate, or systolic blood pressure. RSR13 given after the onset of low-flow ischemia also improved cardiac PCr/ATP ratios and regional function as measured by fractional shortening and regional work. Thus, synthetic allosteric reduction in hemoglobin-oxygen affinity may be a new and important therapeutic strategy to ameliorate the metabolic and functional consequences of cardiac ischemia.  (+info)

Transient and steady-state kinetics of the oxidation of substituted benzoic acid hydrazides by myeloperoxidase. (4/1809)

Myeloperoxidase is the most abundant protein in neutrophils and catalyzes the production of hypochlorous acid. This potent oxidant plays a central role in microbial killing and inflammatory tissue damage. 4-Aminobenzoic acid hydrazide (ABAH) is a mechanism-based inhibitor of myeloperoxidase that is oxidized to radical intermediates that cause enzyme inactivation. We have investigated the mechanism by which benzoic acid hydrazides (BAH) are oxidized by myeloperoxidase, and we have determined the features that enable them to inactivate the enzyme. BAHs readily reduced compound I of myeloperoxidase. The rate constants for these reactions ranged from 1 to 3 x 10(6) M-1 s-1 (15 degrees C, pH 7.0) and were relatively insensitive to the substituents on the aromatic ring. Rate constants for reduction of compound II varied between 6.5 x 10(5) M-1 s-1 for ABAH and 1.3 x 10(3) M-1 s-1 for 4-nitrobenzoic acid hydrazide (15 degrees C, pH 7.0). Reduction of both compound I and compound II by BAHs adhered to the Hammett rule, and there were significant correlations with Brown-Okamoto substituent constants. This indicates that the rates of these reactions were simply determined by the ease of oxidation of the substrates and that the incipient free radical carried a positive charge. ABAH was oxidized by myeloperoxidase without added hydrogen peroxide because it underwent auto-oxidation. Although BAHs generally reacted rapidly with compound II, they should be poor peroxidase substrates because the free radicals formed during peroxidation converted myeloperoxidase to compound III. We found that the reduction of ferric myeloperoxidase by BAH radicals was strongly influenced by Hansch's hydrophobicity constants. BAHs containing more hydrophilic substituents were more effective at converting the enzyme to compound III. This implies that BAH radicals must hydrogen bond to residues in the distal heme pocket before they can reduce the ferric enzyme. Inactivation of myeloperoxidase by BAHs was related to how readily they were oxidized, but there was no correlation with their rate constants for reduction of compounds I or II. We propose that BAHs destroy the heme prosthetic groups of the enzyme by reducing a ferrous myeloperoxidase-hydrogen peroxide complex.  (+info)

A comparison of electron-capture GLC, electrolytic-conductivity GLC and UV-absorption HPLC for the analysis of some herbicides in foods. (5/1809)

A comparison of gas chromatography with electron-capture or electrolytic-conductivity (nitrogen mode) detection, and high-pressure liquid chromatography (HPLC) with UV-absorption detection (254 nm) was carried out for the analysis of several herbicides in foods. Linuron, propanil, terbacil, benzoylprop-ethyl, and the fungicide DCNA in samples of cabbage, corn, potato, and wheat spiked at 2 and 0.2 ppm were examined. The pesticides were extracted with acetone, partitioned into petroleum ether-methylene chloride, and cleaned up on a 2% deactivated Florisil column before direct chromatographic analysis. Electron-capture gas-liquid chromatography (GLC) was most suitable for DCNA and benzoylprop-ethyl while UV-absorption HPLC was best for terbacil analysis. Linuron and propanil gave similar results for both electron-capture GLC and HPLC. Electrolytic-conductivity GLC could detect all pesticides at the 0.2 ppm level and exhibited the least number of extraneous peaks in the chromatograms.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (6/1809)

We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and high-density lipoprotein-induced cholesterol efflux in macrophages. (7/1809)

We investigated the effects of a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl)ureido]methyl]cyclohexane), on ACAT activities in macrophages originating from several species and high-density lipoprotein (HDL)-induced cholesterol efflux in phorbol 12-myristate 13-acetate (PMA)-treated THP-1 cells. NTE-122 inhibited cell-free ACAT activities in human PMA-treated THP-1 cells and mouse J774.1 cells with IC50 values of 0.88 and 360 nM, respectively. NTE-122 competively inhibited the ACAT activity in PMA-treated THP-1 cells. NTE-122 also inhibited cellular ACAT activities in PMA-treated THP-1 cells, rat peritoneal macrophages and J774.1 cells with IC50 values of 3.5, 84 and 6800 nM, respectively. Furthermore, NTE-122 prevented cholesterol accumulation in PMA-treated THP-1 cells incubated with acetylated low density lipoprotein, simultaneously with HDL, while it caused accumulation of a significant amount of free cholesterol in the absence and even in the presence of HDL. NTE-122 also enhanced HDL-induced cholesterol efflux from established foam cells converted from PMA-treated THP-1 cells. These results suggest that NTE-122, capable of inhibiting macrophage ACAT activity in humans more strongly than those in the other species, exhibits anti-atherogenic effects by preventing the foam cell formation and enhancing the foam cell regression in humans.  (+info)

Regulation of Ca2+ transport by sarcoplasmic reticulum Ca2+-ATPase at limiting [Ca2+]. (8/1809)

The factors regulating Ca2+ transport by isolated sarcoplasmic reticulum (SR) vesicles have been studied using the fluorescent indicator Fluo-3 to monitor extravesicular free [Ca2+]. ATP, in the presence of 5 mM oxalate, which clamps intravesicular [Ca2+] at approximately 10 microM, induced a rapid decline in Fluo-3 fluorescence to reach a limiting steady state level. This corresponds to a residual medium [Ca2+] of 100 to 200 nM, and has been defined as [Ca2+]lim, whilst thermodynamic considerations predict a level of less than 1 nM. This value is similar to that measured in intact muscle with Ca2+ fluophores, where it is presumed that sarcoplasmic free [Ca2+] is a balance between pump and leaks. Fluorescence of Fluo-3 at [Ca2+]lim was decreased 70% to 80% by histidine, imidazole and cysteine. The K0.5 value for histidine was 3 mM, suggesting that residual [Ca2+]lim fluorescence is due to Zn2+. The level of Zn2+ in preparations of SR vesicles, measured by atomic absorption, was 0.47+/-0.04 nmol/mg, corresponding to 0.1 mol per mol Ca-ATPase. This is in agreement with findings of Papp et al. (Arch. Biochem. Biophys., 243 (1985) 254-263). Histidine, 20 mM, included in the buffer, gave a corrected value for [Ca2+]lim of 49+/-1.8 nM, which is still higher than predicted on thermodynamic grounds. A possible 'pump/leak' mechanism was tested by the effects of varying active Ca2+ transport 1 to 2 orders with temperature and pH. [Ca2+]lim remained relatively constant under these conditions. Alternate substrates acetyl phosphate and p-NPP gave similar [Ca2+]lim levels even though the latter substrate supported transport 500-fold slower than with ATP. In fact, [Ca2+]lim was lower with 10 mM p-NPP than with 5 mM ATP. The magnitude of passive efflux from Ca-oxalate loaded SR during the steady state of [Ca2+]lim was estimated by the unidirectional flux of 45Ca2+, and directly, following depletion of ATP, by measuring release of 40Ca2+, and was 0.02% of Vmax. Constant infusion of CaCl2 at [Ca2+]lim resulted in a new steady state, in which active transport into SR vesicles balances the infusion rate. Varying infusion rates allows determination of [Ca2+]-dependence of transport in the absence of chelating agents. Parameters of non-linear regression were Vmax=853 nmol/min per mg, K0.5(Ca)=279 nM, and nH(Ca)=1.89. Since conditions employed in this study are similar to those in the sarcoplasm of relaxed muscle, it is suggested that histidine, added to media in studies of intracellular Ca2+ transients, and in the relaxed state, will minimise contribution of Zn2+ to fluophore fluorescence, since it occurs at levels predicted in this study to cause significant overestimation of cytoplasmic free [Ca2+] in the relaxed state. Similar precautions may apply to non-muscle cells as well. This study also suggests that [Ca2+]lim in the resting state is a characteristic feature of Ca2+ pump function, rather than a balance between active transport and passive leakage pathways.  (+info)

Ly et al: CAA Predisposes to rt-PA Related Hhemorrhage Cerebral b-Amyloid Detected by Pittsburgh Compound B Positron Emission Topography Predisposes to Recombinant Tissue Plasminogen Activator-Related Hemorrhage John V. Ly,1 Christopher C. Rowe,2 Victor L. Villemagne,2 Jorge A. Zavala,1 Henry Ma,1 Graeme OKeefe,2 Sylvia J. Gong,2 Rico Gunawan,1 Leonid Churilov,1 Tim Saunder,2 Uwe Ackerman,2 Henri Tochon-Danguy,2 and Geoffrey A. Donnan1,3 Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral b-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, ...
Name: 2,6-Dichioro-4-nitroaniline CA Name: Benzenamine,2,6-dichloro-4-nitro- Molecular Structure: 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 2,6-Dichioro-4-nitroaniline,Benzenamine,2,6-dichloro-4-nitro-,CAS 99-30-9,207.00,C6H4Cl2N2O2 Molecular Formula:C6H4Cl2N2O2 Molecular Weight: 207.00 CAS Registry Number: 99-30-9
5-chloro-2-methyl-4-nitroaniline chemical properties, What are the chemical properties of 5-chloro-2-methyl-4-nitroaniline 13852-51-2, What are the physical properties of 5-chloro-2-methyl-4-nitroaniline ect.
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Aniline-induced methemoglobinemia, loss of circulating blood cells, blood … Earlier we have shown that aniline exposure leads to increased nitration of proteins in the spleen. The damaged hemoglobin can not carry oxygen. Aniline can be toxic if ingested, inhaled, or by skin contact. Toxicol. Toxicol Appl Pharmacol. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. New insights into aniline toxicity: Aniline exposure triggers envelope stress and extracellular polymeric substance formation in. This study involves the relationship between the chemical structure and hemotoxic markers of aniline and its halogenated analogs. https://doi.org/10.1016/j.jhazmat.2019.121571. [http://dx. (. Aniline induces extracellular polymeric substance and aggregates formation in strain JA2. (, Induction of signal transduction cascades and activation of transcription factors AP-1 and NF-B. Epub 2010 Nov 8. Human cancer data are insufficient to ...
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TY - JOUR. T1 - Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies. AU - Su, Yi. AU - Flores, Shaney. AU - Wang, Guoqiao. AU - Hornbeck, Russ C.. AU - Speidel, Benjamin. AU - Joseph-Mathurin, Nelly. AU - Vlassenko, Andrei G.. AU - Gordon, Brian A.. AU - Koeppe, Robert A.. AU - Klunk, William E.. AU - Jack, Clifford R.. AU - Farlow, Martin R.. AU - Salloway, Stephen. AU - Snider, Barbara J.. AU - Berman, Sarah B.. AU - Roberson, Erik D.. AU - Brosch, Jared. AU - Jimenez-Velazques, Ivonne. AU - van Dyck, Christopher H.. AU - Galasko, Douglas. AU - Yuan, Shauna H.. AU - Jayadev, Suman. AU - Honig, Lawrence S.. AU - Gauthier, Serge. AU - Hsiung, Ging Yuek R.. AU - Masellis, Mario. AU - Brooks, William S.. AU - Fulham, Michael. AU - Clarnette, Roger. AU - Masters, Colin L.. AU - Wallon, David. AU - Hannequin, Didier. AU - Dubois, Bruno. AU - Pariente, Jeremie. AU - Sanchez-Valle, Raquel. AU - Mummery, Catherine. AU - Ringman, John M.. AU - Bottlaender, ...
Aniline dioxygenase is a multicomponent Rieske nonheme-iron dioxygenase enzyme isolated from Acinetobacter sp. strain YAA. Saturation mutagenesis of the substrate-binding pocket residues, which were identified using a homology model of the α subunit of the terminal dioxygenase (AtdA3), was used to probe the molecular determinants of AtdA substrate specificity. The V205A mutation widened the substrate specificity of aniline dioxygenase to include 2-isopropylaniline, for which the wild-type enzyme has no activity. The V205A mutation also made 2-isopropylaniline a better substrate for the enzyme than 2,4-dimethylaniline, a native substrate of the wild-type enzyme. The I248L mutation improved the activity of aniline dioxygenase against aniline and 2,4-dimethylaniline approximately 1.7-fold and 2.1-fold, respectively. Thus, it is shown that the α subunit of the terminal dioxygenase indeed plays a part in the substrate specificity as well as the activity of aniline dioxygenase. Interestingly, the ...
Aniline dioxygenase is a multicomponent Rieske nonheme-iron dioxygenase enzyme isolated from Acinetobacter sp. strain YAA. Saturation mutagenesis of the substrate-binding pocket residues, which were identified using a homology model of the α subunit of the terminal dioxygenase (AtdA3), was used to probe the molecular determinants of AtdA substrate specificity. The V205A mutation widened the substrate specificity of aniline dioxygenase to include 2-isopropylaniline, for which the wild-type enzyme has no activity. The V205A mutation also made 2-isopropylaniline a better substrate for the enzyme than 2,4-dimethylaniline, a native substrate of the wild-type enzyme. The I248L mutation improved the activity of aniline dioxygenase against aniline and 2,4-dimethylaniline approximately 1.7-fold and 2.1-fold, respectively. Thus, it is shown that the α subunit of the terminal dioxygenase indeed plays a part in the substrate specificity as well as the activity of aniline dioxygenase. Interestingly, the ...
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Polymeric compositions are disclosed comprising protonated, electrically conducting polyaniline; cyclic organic compounds capable of forming ring-ring interactions with the six-membered rings of the polyaniline and hydrogen bonding with the NH groups of the polyaniline; and anionic surface active additives. According to the invention, no particular requirements are posed for the counter-ions of polyaniline, which allows for the use of non-functionilized counter-ions. The conducting polyaniline complexes of the invention are processible in the fluid-phase and exhibit significantly improved electrical properties.
CH421 Experiment 2 Nitration of Aniline: a three-step protecting group strategy to prepare p-nitroaniline Reading: Organic Chemistry by John McMurry, 8e, Chapter Techniques: recrystallization,
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To investigate the exposure-toxicity relationship of bosutinib and to identify the target trough plasma concentration (C0). The toxicity and C0 of bosutinib in Japanese chronic myeloid leukemia (CML) patients were monitored every 2 weeks for the first 3 months of treatment, and subsequently once a month during the 6 months after beginning 500 mg/day of standard dose (SD group, n = 10) or beginning 100 mg/day and increased by 100 mg every 2 weeks of dose escalation (DE group, n = 15). Nine of 10 patients (90%) in the SD group were not able to continue bosutinib therapy without interruption due to adverse events, compared to 2 patients (13.5%) in the DE group. The total duration of treatment interruption was 35 and 14 days in the SD and DE groups, respectively. The median time until liver dysfunction or diarrhea was day 28 and day 1 in the SD group, and day 53.5 and day 19 in the DE group, respectively. The cumulative dose of bosutinib was comparable between the SD and DE groups (51,700 vs. 53,550 mg,
By Rik Ossenkoppele, Niels D. Prins, Yolande A.L. Pijnenburg, Afina W. Lemstra, Wiesje M. van der Flier, Sofie F. Adriaanse, Albert D. Windhorst, Ron L.H. Handels, Claire A.G. Wolfs, Pauline Aalten, Frans R.J. Verhey, Marcel M. Verbeek, Mark A. van Buchem, Otto S. Hoekstra, Adriaan A. Lammertsma, Philip Scheltens, Bart N.M. van Berckel Abstract: Background: [11C]Pittsburgh compound B ([11C]PIB) and [18F]-2-fluoro-2-deoxy-D-glucose ([18F]FDG) PET measure fibrillar amyloid-β load and glucose metabolism, respectively. We evaluated the impact of these tracers on the diagnostic process in a memory clinic population.Methods: One hundred fifty-four patients underwent paired dynamic [11C]PIB and static [18F]FDG PET scans shortly after completing Read & Research Alzheimers More. ...
Radiotracer development activities within the PET Facility focus primarily on neuroscience applications, with an emphasis on in vivo imaging of neurodegenerative disease pathology. Since its inception in 1992, Dr. Chester Mathis, Director of the PET Facility and Senior Radiochemist, has led these efforts. A long-standing collaboration with the laboratory of Dr. William E. Klunk, Dept. of Psychiatry, yielded the first successful PET imaging agent for imaging beta-amyloid (Aβ) plaques, an abnormal protein aggregate that is one of the pathologic hallmarks of Alzheimers Disease (AD). This agent, [11C]Pittsburgh Compound B (or [11C]PiB), continues to be an important investigational tool used worldwide in human AD research. A radiofluorinated analog of PiB developed by the PET Facility is under license to GE Healthcare, which is marketed as Vizamyl™ and approved by the U.S. FDA for clinical use. Currently, efforts in this area of research are focused on the development and application of PET ...
Aniline Compounds are organic compounds, consisting of a phenyl group attached to an amine group, with a molecular formula (C6H5NH2)
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Equipment made of glass-lined steel is used when manufacturing or processing aggressive chemicals such as aniline derivatives and strong acids such as sulfuric, nitric or hydrochloric acid. The Achilles heel of such glass-lined systems is the gaskets needed to seal the joints between components. Exposure to aggressive media causes the seals to degrade over time, resulting in damage to ...
I. SUBSTANCE IDENTIFICATION. A. Substance: Methylenedianiline (MDA). B. Permissible Exposure:. 1. Airborne: Ten parts per billion parts of air (10 ppb), time-weighted average (TWA) for an 8-hour workday and an action level of five parts per billion parts of air (5 ppb).. 2. Dermal: Eye contact and skin contact with MDA are not permitted.. C. Appearance and odor: White to tan solid; amine odor. II. HEALTH HAZARD DATA. A. Ways in which MDA affects your health. MDA can affect your health if you inhale it, or if it comes in contact with your skin or eyes. MDA is also harmful if you happen to swallow it. Do not get MDA in eyes, on skin, or on clothing.. B. Effects of overexposure. 1. Short-term (acute) overexposure: Overexposure to MDA may produce fever, chills, loss of appetite, vomiting, jaundice. Contact may irritate skin, eyes and mucous membranes. Sensitization may occur.. 2. Long-term (chronic) exposure. Repeated or prolonged exposure to MDA, even at relatively low concentrations, may cause ...
Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the prototypical aromatic amine. Being a precursor to many industrial chemicals, its main use is in the manufacture of precursors to polyurethane. Like most volatile amines, it possesses the somewhat unpleasant odour of rotten fish. It ignites readily, burning with a smoky flame characteristic of aromatic compounds. Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples.
HOPA = Hemalaun, Orange G, Phosphormolybdenic acid, Aniline blue Cell nuclei are stained with hemalaun or Weigerts iron-hematoxylin and then counterstained with a dye mixture of orange-phosphormolybden with aniline blue.. ...
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
Visit ChemicalBook To find more Aniline(62-53-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. You can also browse global suppliers,vendor,prices,Price,manufacturers of Aniline(62-53-3). At last,Aniline(62-53-3) safety, risk, hazard and MSDS, CAS,cas number,Use,cas no may also be you need.
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Stable, concentrated solutions of high molecular weight polyaniline. In order to process high quality fibers and other articles possessing good mechanical properties, it is known that solution concentrations of the chosen polymer should be in the range from 15-30% (w/w). Moreover, it is desirable to use the highest molecular weight consistent with the solubility properties of the polymer. However, such solutions are inherently unstable, forming gels before processing can be achieved. The present invention describes the addition gel inhibitors (GIs) to the polymer solution, thereby permitting high concentrations (between 15% and 30% (w/w)) of high molecular weight ((Mw)|120,000, and (Mn)|30,000) emeraldine base (EB) polyaniline to be dissolved. Secondary amines have been used for this purpose in concentrations which are small compared to those which might otherwise be used in a cosolvent role therefor. The resulting solutions are useful for generating excellent fibers, films, coatings and other objects,
Protein expression of CDK1 and p-CDK1 in rat spleens.(A) Western blot determination of CDK1 and p-CDK1 protein expression in control and aniline-treated rats. (
INTRODUCTION: Adults with Down syndrome (DS) are predisposed to Alzheimers disease (AD) and reveal early amyloid beta (Aß) pathology in the brain. Positron emission tomography (PET) provides an in vivo measure of Aß throughout the AD continuum. Due to the high prevalence of AD in DS, there is need for longitudinal imaging studies of Aß to better characterize the natural history of Aß accumulation, which will aid in the staging of this population for clinical trials aimed at AD treatment and prevention. METHODS: Adults with DS (N = 79; Mean age (SD) = 42.7 (7.28) years) underwent longitudinal [C-11]Pittsburgh compound B (PiB) PET. Global Aß burden was quantified using the amyloid load metric (AßL). Modeled PiB images were generated from the longitudinal AßL data to visualize which regions are most susceptible to Aß accumulation in DS. AßL change was evaluated across Aß(-), Aß-converter, and Aß(+) groups to assess longitudinal Aß trajectories during different stages of AD-pathology ...
Navitoclax has been used in trials studying the treatment and basic science of Solid Tumors, Non-Hodgkins Lymphoma, EGFR Activating Mutation, Chronic Lymphoid Leukemia, and Hematological Malignancies, among others. Navitoclax is an orally bioavailable small molecule inhibitor of Bcl-2 family proteins. It is a substance being studied in the treatment of lymphomas and other types of cancer. It blocks some of the enzymes that keep cancer cells from dying.
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Aniline Aniline Other names PhenylamineAminobenzeneBenzenamine Identifiers CAS number 62-53-3 SMILES NC1=CC=CC=C1 Properties Molecular formula C6H7N Molar mass
Suppliers List, E-mail/RFQ Form, Molecular Structure, Weight, Formula, IUPAC, Synonyms for BENZENAMINE, 2-FLUORO-4-METHYL-, HYDROBROMIDE (CAS No. 874186-81-9)
21889-05-4 - BBYJHUAEFSHMHU-UHFFFAOYSA-N - Benzenamine, 4-(1H-indol-2-yl)- (9CI) - Similar structures search, synonyms, formulas, resource links, and other chemical information.
32971-60-1 - BZOLKXGJNJUPQQ-SAPNQHFASA-N - Benzenamine, 3,4-dichloro-N-(1-(2-propenyl)-2-piperidinylidene)- - Similar structures search, synonyms, formulas, resource links, and other chemical information.
Searching for two-dimensional (2D) layered materials with diverse electronic conductivities is one of the leading topics in materials science. Herein, from first-principles calculations, we report the thickness-dependent conductivity of layered 2D polyaniline (PANI) structures. When PANI is thinned down to a
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Page contains details about polyaniline nanotube film . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
A method is provided for the preparation of a conductive composition containing a polymerized aromatic amine wherein the aromatic amine is oxidatively polymerized in an acidic aqueous medium in the presence of an oxidizing agent, a doping agent and an aromatic polyalkyleneoxide in an amount sufficient to stabilize the resulting composition. Preferably, the aromatic amine is aniline or a substituted aniline. Compositions produced by such method are also disclosed. These compositions are useful for treating various substrates to make such substrates conductive.
Name: 2-Chloro-4-nitrobenzenamine CA Name: Benzenamine,2-chloro-4-nitro- Molecular Structure: 2-Chloro-4-nitrobenzenamine,Benzenamine,2-chloro-4-nitro-,CAS 121-87-9,172.57,C6H5ClN2O2 2-Chloro-4-nitrobenzenamine,Benzenamine,2-chloro-4-nitro-,CAS 121-87-9,172.57,C6H5ClN2O2 Molecular Formula:C6H5ClN2O2 Molecular Weight: 172.57 CAS Registry Number: 121-87-9
S-2765, which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm. Packaging 10mg Price US$68
This dose-escalating study is to determine the safety, pharmacokinetics, and preliminary efficacy of venetoclax in combination with navitoclax and chemotherapy
TY - JOUR. T1 - Iridium/Bipyridine-Catalyzed ortho-Selective C-H Borylation of Phenol and Aniline Derivatives. AU - Li, Hong Liang. AU - Kanai, Motomu. AU - Kuninobu, Yoichiro. PY - 2017/11/3. Y1 - 2017/11/3. N2 - An iridium-catalyzed ortho-selective C-H borylation of phenol and aniline derivatives has been successfully developed. Iridium/bipyridine-catalyzed C-H borylation generally occurred at the meta- and para-positions of aromatic substrates. Introduction of an electron-withdrawing substituent on the bipyridine-type ligand and a methylthiomethyl group on the hydroxy and amino groups of the phenol and aniline substrates, however, dramatically altered the regioselectivity, affording exclusively ortho-borylated products. The reaction proceeded in good to excellent yields with good functional group tolerance. C-H borylation was applied to the synthesis of a calcium receptor modulator.. AB - An iridium-catalyzed ortho-selective C-H borylation of phenol and aniline derivatives has been ...
ChemicalBook provide Chemical industry users with 2,6-Dimethylaniline(87-62-7) Boiling point Melting point,2,6-Dimethylaniline(87-62-7) Density MSDS Formula Use,If You also need to 2,6-Dimethylaniline(87-62-7) Other information,welcome to contact us.
Latest China HS Code & tariff for n dimethylaniline - Tariff & duty, regulations & restrictions, landed cost calculator, customs data for n dimethylaniline in ETCN. China customs statistics trade data.
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Experiments performed in mice in which expression of the extracellular calcium-sensing receptor (CaSR) was completely nullified specifically in parathyroid cells, chondrocytes, or cells of the osteoblast lineage have identified phenotypes that indicate a key role for the CaSR in embryonic development of the skeleton, postnatal bone formation, and osteoblast differentiation that are independent of the calcitropic hormone axis. These long-awaited studies further clarify the signaling relationships between the parathyroid gland, kidney, and metabolic bone disease in patients with mutations in the gene encoding the CaSR, and they provide new insights into understanding the signaling pathways involving the CaSR in skeletal cells.. ...
TY - JOUR. T1 - Photothermal ablation of cancer cells using self-doped polyaniline nanoparticles. AU - Hong, Yoochan. AU - Cho, Wonseok. AU - Kim, Jeonghun. AU - Hwng, Seungyeon. AU - Lee, Eugene. AU - Heo, Dan. AU - Ku, Minhee. AU - Suh, Jin Suck. AU - Yang, Jaemoon. AU - Kim, Jung Hyun. PY - 2016/3/24. Y1 - 2016/3/24. N2 - Water-stable confined self-doping polyaniline nanocomplexes are successfully fabricated by nano-assembly using lauric acid both as a stabilizer and as a localized dopant. In particular, the colloidal stability of the polyaniline nanocomplexes in neutral pH and the photothermal potential by near-infrared light irradiation are characterized. We demonstrate that confined self-doping polyaniline nanocomplexes as a photothermal nanoagent are preserved in the doped state even at a neutral pH. Finally, confined self-doping polyaniline nanocomplexes aided by lauric acid are successfully applied for the photothermal ablation of cancer cells.. AB - Water-stable confined self-doping ...
Polyaniline shows great potential and promises wide application in the biomedical field thanks to its intrinsic conductivity and material properties, which closely resemble natural tissues. Surface properties are crucial, as these predetermine any interaction with biological fluids, proteins and cells. An advantage of polyaniline is the simple modification of its surface, e.g., by using various dopant acids. An investigation was made into the adhesion, proliferation and migration of mouse embryonic fibroblasts on pristine polyaniline films and films doped with sulfamic and phosphotungstic acids. In addition, polyaniline films supplemented with poly (2-acrylamido-2-methyl-1-propanesulfonic) acid at various ratios were tested. Results showed that the NIH/3T3 cell line was able to adhere, proliferate and migrate on the pristine polyaniline films as well as those films doped with sulfamic and phosphotungstic acids; thus, utilization of said forms in biomedicine appears promising. Nevertheless, ...
광여기된 안트라센은 N,N-dimethylaniline(DMA)과 같은 기저 상태의 전자주개와 안정한 착물인 excited complex(exciplex)를 형성하는 것으로 잘 알려져 있다. 본 연구에서는 exciplex 형성 및 분해 반응에 미치는 전자주개의 구조적인 영향을 알아보기 위해 DMA 유도체인 N,N-dimethyl-o-toluidine(DMOT), N,N-dimethyl-m-toluidine(DMMT), N,N-dimethyl-p-toluidine(DMPT), 4-tert-butyl-dimethylaniline(BDMA), N,N,2,4,6-pentamethylaniline(PMA) 등을 사용하였다. 측정 방법으로는 absorption과 emission 및 time resolved spectroscopy를 이용하였다. DMA 페닐 링의 meta나 para 위치 치환은 안트라센과의 exciplex 형성에 영향을 미치지 않았다. 특히 para위치에 tertiary 부틸기가 붙은 BDMA는 메틸 기가 붙은 DMPT와 비슷한 결과를 보여 para 위치에 치환된 그룹의 크기는 exciplex 형성에 큰 영향을 주지 않음을 알 수 있었다. 이와 달리, ortho 위치의 치환은 ...
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A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol) diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose.
D611 - 12(2016) Standard Test Methods for Aniline Point and Mixed Aniline Point of Petroleum Products and Hydrocarbon Solvents , aniline point, aromatics, mixed aniline point,,
Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study has been published in Brain. This research was
Objective: To investigate the particular pathology of the Arctic APP (APParc) early-onset familial Alzheimer disease (eoFAD) mutation for the first time in vivo with PET in comparison with other eoFAD mutations and sporadic Alzheimer disease (sAD).. Methods: We examined 2 APParc mutation carriers together with 5 noncarrier siblings cross-sectionally with C-11-labeled Pittsburgh compound B (PiB) and F-18-fluorodeoxyglucose (FDG) PET, as well as MRI, CSF biomarkers, and neuropsychological tests. Likewise, we examined 7 patients with sAD, 1 carrier of a presenilin 1 (PSEN1) mutation, 1 carrier of the Swedish APP (APPswe) mutation, and 7 healthy controls (HCs).. Results: Cortical PiB retention was very low in the APParc mutation carriers while cerebral glucose metabolism and CSF levels of A beta(1-42), total and phosphorylated tau were clearly pathologic. This was in contrast to the PSEN1 and APPswe mutation carriers revealing high PiB retention in the cortex and the striatum in combination with ...
Add to Cart #01 Canola Yellow Eggshell Pysanka Dye. Treat with beeswax, such as Skidmores. I assume this is why it was stopped being used in the 60s guitar making? My original 14 bike was stolen. Hello, It has been many years since I have used Lee Valley Aniline Dyes. It was derived from coal tar and produced a deep purple color; mauve. Also produced a collection of new colors but identifying new commercialy viable aniline base dyes is di ï¬ cult. Ukrainian Easter Eggs (Pysanky) love vivid colours! 5. 1951. Do not use Indian dye or other water-based dyes. leather furniture showroom for â ¦ 127 Followers, 126 Following, 824 pins - See what Gabriela Dadario (dadario001) has discovered on Pinterest, the worlds biggest collection of ideas. Either an alcohol- or oil-based aniline dye. Aniline Water Stains. $1.60 CAD Qty. Gift of Joyce and Fred Zemans, 2008. This legendary 5 color guitar dye kit contains the rich, and vibrant primary dye colors of Red, Black, Yellow, Brown and Blue per every ...
TY - JOUR. T1 - Intermediates in the reaction of aniline with formaldehyde catalyzed by acids. AU - Bochkarev, V. V.. AU - Soroka, L. S.. PY - 2000/5/1. Y1 - 2000/5/1. N2 - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the semiempirical MNDO method. According to the calculation results, protonated N-(hydroxymethyl)aniline and ortho-, meta-, and paraσ-complexes are formed through the ion-dipole complex. Further transformations of these intermediates, which determine the structure of the final products, depend on the possibility of proton abstraction from the σ-complexes with formation of a quinonimine structure, as well as on the lability of the hydroxymethyl group in the protonated amino alcohol.. AB - The relative stabilities and reactivities of possible intermediates in the reaction of aniline with formaldehyde under conditions of acid catalysis were estimated by the ...
Aspirin and azo derivatives have been widely studied and have drawn considerable attention due to diverse biological activities. In this study, a series of 4-[(halophenyl)diazenyl]phenyl aspirinate derivatives were synthesized from the reaction of aspirin with 4-[(halophenyl)diazenyl]phenol via esterification, in the presence of DCC/DMAP in DCM with overall yield of 45-54%. 4-[(Halophenyl)diazenyl]phenol was prepared prior to esterification from coupling reaction of aniline derivatives and phenol in basic solution. All compounds were characterized using elemental analysis, FTIR, and 1H and 13C NMR spectroscopies. All compounds were screened for their anticancer activities against nasopharyngeal cancer (NPC) HK-1 cell lines and the viability of cultured cells was determined by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxylmethoxylphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]-based colorimetric assay. 4-[(E)-(Fluorophenyl)diazenyl]phenol showed the highest anticancer activity against NPC HK-1 cell ...
This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines.
12. Le texte indique : « 2,6-dimethylaniline (3.0 mL, 2.9 g, 24.4 mmol) ». Quelles relations lient ces valeurs. Vérifier les valeurs données. 13. Montrer que la quantité de matière de lidocaïne que lon devrait théoriquement obtenir est 24,4 mmol. Quelle serait alors la masse de lidocaïne obtenue ? 14. Le texte indique : « The yield of dry product is 4.1 grams, 71.1% based on 2,6-dimethylaniline». b) Quelle masse de lidocaïne est obtenue expérimentalement ? c) Montrer que la quantité de matière de lidocaïne que lon devrait théoriquement obtenir est 24,4 mmol. Quelle serait alors la masse de lidocaïne obtenue ? 15. Définir et calculer le rendement de cette synthèse. Auteur : Brigitte VRAY ...
We examined cortical amyloid-β (Aβ) levels and interactions with apolipoprotein (APOE) ɛ 4 genotype status across empirically-derived mild cognitive impairment (MCI) subgroups and cognitively normal older adults. Participants were 583 ADNI participan
Certain phenols and anilines can be used as electron transfer agents to increase the rate of oxidation of leuco dyes by peroxidase. These phenols and anilines can react with hydrogen peroxide in the presence of peroxidase to provide intermediates which have higher oxidation potentials than the slowly oxidized substrates, e.g. the leuco dyes. These phenols and anilines can be used to advantage in both solution and dry assays of various analytes. They are particularly useful for the determination of an immunologically reactive ligand in an immunoassay.
The theoretical approach to the study of aniline polymerization mechanism has been based on the MNDO-PM3 semi-empirical quantum chemical computations of the heat of formation of aniline dimer and trimer intermediates. The oxidation in aqueous medium without added acid is analyzed. The aniline nitrenium cation is proposed to be the reactive electrophilic species generated by the oxidation of aniline with a two-electron oxidant, ammonium peroxydisulfate, in the initiation phase. 4-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,4-benzoquinonediimine, are the main dimeric products. 2-Aminodiphenylamine and its fully oxidized form, N-phenyl-1,2-benzoquinonediimine, are the most important side products of aniline dimerization. The influence of protonation on the oxidizability of aniline and reaction intermediates was studied. The dominant aniline oligomers have been shown to be linear as well as branched. The importance of reactivity difference between fully oxidized aniline oligomers ...
Electrically conducting polymers induce specific cellular responses at the molecular level. One of the crucial limitations of the use of conducting polymers in tissue engineering is their inability to degrade. The incorporation of conductivity into degradable polymers to obtain materials that are both electroactive and degradable is therefore highly anticipated. Architecture plays an important role in the performance of polymers. To be able to achieve the optimal mechanical, degradation, thermal and biological properties for a particular biomedical application, it is desirable to promote architectural diversity.. In the first part, by combining the electroactivity of conducting polymers and the degradability of aliphatic polyesters, we have designed and synthesized a series of linear, star-shaped, hyperbranched, and crosslinked degradable and electrically conducting polymers and hydrogels based on polylactide (PLA), polycaprolactone (PCL), and aniline oligomers such as aniline trimer, aniline ...
The applicability of air sampling methods for aniline (62533) to its substituted derivatives, o-toluidine (95534), N,N-dimethylaniline (121697), o-anisidine (90040), o-chloraniline (95512), and mixed xylidines, was investigated. Aniline air sampling employed a tube containing two 50 milligram sections of 45:60 mesh silica gel. The effectiveness of the first sorbent section was described by the qua
View Notes - Dolbier HW Solutions 231 from CHM 2210 at University of Florida. 225 ALKYNES Treatment of compound A with sodium amide converts it to compound B. Compound B on ozonolysis gives a diacid
A study was conducted to quantitate tissue macromolecular adduct formation after induction of drug metabolizing enzymes or long term oral administration of 4,4-methylenebis(2-chloroaniline) (101144) (MOCA), a model aromatic amine, in the rat. Male Sprague-Dawley- rats were administered carbon-14 (C-14) labeled MOCA at 28.1 micromole/kilogram (micromol/kg) daily for up to 28 days either by gavage
Literature References: Prepn: Finger, J. Prakt. Chem. [2] 79, 493 (1909); Mayer, Ber. 47, 1161 (1914). Acute toxicity: G. Ya. Kelman et al., Kauch. Rezina 26(9), 28 (1967), C.A. 67, 120013m (1967). Review of carcinogenicity studies: IARC Monographs vol. 4, 65-71 (1974); of toxicology and human exposure: Toxicological Profile for 4,4¢-Methylenebis(2-chloroaniline) (PB95-100186, 1994) 146 p. ...
Growing demand for 4-Nitro Aniline from the paints and coatings and dye industry is the major factor driving the growth of global 4-Nitro Aniline market
Ive always heard that generally speaking, Aniline finished leathers are superior because they are usually reserved for full grain hides, and also that cheaper leathers would have a white/blue/gray center. But after receiving some samples of Aniline dyed leather from one of the better French tanne...
This trial aim was to determine whether 18 F-florbetaben PET imaging can accurately identify and differentiate between cardiac amyloidosis and hypertensive
Advice and warnings for the use of Florbetapir F 18 (Amyvid) during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out
The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [18F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR, occurring when the specific binding reaches a transient equilibrium . Here, we have investigated whether the time to equilibrium affects the agreement between SUVR and DVR across different brain regions. We show that the time required to reach equilibrium differs across brain regions, resulting in region-specific biases. However, even though the 80-100 min post-injection time window did not show the smallest bias numerically, the disagreement between SUVR and DVR varied least between regions during this time. In conclusion, our findings suggest a regional component to the bias of SUVR related to the ...
Innovative genomic test for bosutinib personalised pharmacogenomic analysis to explore how your genes can affect and modulate your response to bosutinib ...
Lightweight flexible carbon nanotube (CNT)/polyaniline (PANI) free standing films having the highest reported specific shielding effectiveness (SSE) of 7.5 × 104 dB cm2 g−1 were developed using amine-functionalized CNTs, which could be attributed to the high conductivity (3009 S cm−1) and low density of the
A series of anthrazoline-containing monomers are synthesized, and eight co-polyamides of different chemical structures, containing 1,9-anthrazoline fragments in the main chain, are obtained and investigated. Photoluminescent, stress-strain, and thermal properties of these polymers are studied. It is shown that polymers with fragments of 4,4-(pyrido[3,2-g]-quinoline-2,8-diyl)dianiline and 4,4-(10-methylpyrido[3,2-g]quinoline-2,8-diyl)dianiline possess an intense luminescence in the range 550-650 nm. The performed investigations made it possible to determine the effect of substituents of various natures in the anthrazoline cycle and the position of amide group (meta- and para-configurations) on optical, stress-strain, and thermal properties of copolymers, opening up a prospect for further developments of principles of design of polymers with optimal characteristics ...
Production of this molecule is increased by London and Arctic mutations and is diminished by an allele found in some Icelanders. Site-specific levels of this molecule were integral to the now-discounted peripheral sink hypothesis. This molecule can be imaged with PET using Pittsburgh compound B. Its degradation is lowered in people with the ApoE epsilon 4 allele. A protein triplicated in Down syndrome is processed into C99 before being refined into this molecule. This 40- to 42-residue peptide is generated by PSEN1 in the gamma secretase complex following BACE-1 cleavage of the precursor protein APP. Cortical deposition of it accelerates tau propagation and formation of neurofibrillary tangles. For 10 points, name this peptide that comprises the insoluble plaques seen in Alzheimers disease ...
SWISS-MODEL Repository entry for Q28505 (FMO2_MACMU), Dimethylaniline monooxygenase [N-oxide-forming] 2. Macaca mulatta (Rhesus macaque)
Fluorescent Dyes , Enzyme Detection Reagents , Caspase 9 Substrate 1, chromogenic; pNA (4-nitroaniline)-derived caspase substrates are widely used for the colorimetric detection of various caspase activities. Cleavage of pNA peptides by caspases generates pNA that is monitored colorimetrically at ~405 nm. pNA has maximum absorption around 408 nm.; Caspase-9 substrate; Ac-LEHD-pNA; Ac-Leu-Glu-His-Asp-pNA
GPR88, an orphan receptor richly expressed in the striatum, is implicated in a number of basal ganglia-associated disorders. In order to elucidate the functions of GPR88, an in vivo probe appropriate for CNS investigation is required. We previously reported that 2-PCCA was able to modulate GPR88-mediated cAMP production through a G alpha(i)-coupled pathway. Early structure-activity relationship (SAR) studies suggested that the aniline moiety of 2-PCCA is a suitable site for diverse modifications.
Srdan Verstovsek, MD, PhD, discusses the rationale for utilizing ruxolitinib and navitoclax in patients with relapsed/refractory myelofibrosis.
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Two small prospective studies have investigated the extent to which cerebral Aß load, measured using PiB PET neuroimaging, is related to change in cognitive function in healthy older adults.8,11 As in the current study, the entire group of healthy older adults from the Melbourne Healthy Aging Study cohort showed no change in memory or nonmemory composite scores 18 or 36 months after a baseline PiB PET scan. However, when adults in this group were classified as having high or low cerebral Aß load, using the same criterion as that used in the current study, healthy older adults with high cerebral Aß load showed statistically significant decline of a moderate magnitude on both memory and nonmemory composite scores 36 months after PET scanning.8 However, by the 36-month assessment, 25% of healthy older adults with high cerebral Aß load met the clinical criteria for mild cognitive impairment (MCI). Thus, the general decline in cognition observed at 36 months postscan reflected this change in ...
2-(4-Aminophenyl)-2-methylpropan-1-ol Cas No 18755-56-1 - A wide of 2-(4-Aminophenyl)-2-methylpropan-1-ol knowledge covers characteristics, safety, usage, MSDS/SDS & Reach registration data at Echemi.com
What is 3-Amino-5-Fluorobenzotrifluoride?Where can buy 3-Amino-5-Fluorobenzotrifluoride or what is the price of 3-Amino-5-Fluorobenzotrifluoride, 3-Amino-5-Fluorobenzotrifluoride producer, 3-Fluoro-5-(trifluoromethyl)aniline factory or 3-Amino-5-fluorobenzotrifluoride supplier? Welcome to contact us for 3-Fluoro-5-(trifluoromethyl)aniline COA or MSDS., China and India manufacturer of 3-Amino-5-Fluorobenzotrifluoride CAS:454-67-1, China and India 3-Amino-5-Fluorobenzotrifluoride CAS:454-67-1
Notable examples include: The production of aniline compounds. General oxidizing agent. Victor Meyer type nucleophilic ... Silver nitrite is an inorganic compound with the formula AgNO2. Silver nitrite has many applications. ... substitution reactions with organobromides or organoiodides forming nitro compounds. Nitroalkene synthesis with nitryl iodide ...
Aniline derivatives are converted to a diazo compounds. In years following the work Baudisch and Cronheim did, Konecny and ...
... bladder cancer in dye workers exposed to aniline compounds; and leukemia and lymphoma in chemical workers exposed to benzene. ...
Aniline 5 is converted to compound 6, in three steps; conversion to an ortho-aminothiol through the Herz-reaction (aniline 5 ... In a last step the nitrile is hydrolysed resulting in 6. This compound is converted to 7 via a ring-closing reaction and ... The compound, (thioindoxyl, 7) is an important intermediate in the organic synthesis of some dyes. Condensation with ... The Herz reaction, named after the chemist Richard Herz, is the chemical conversion of an aniline-derivative (1) to a so-called ...
The coupler compounds (couplers) are meta-substituted derivatives of aniline. They come in three major classes based on the ... 2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... These compounds produce broad-band absorption when they react to form dyes, allowing for more natural-looking hair colors. The ... Semi-permanent hair color uses compounds of lower molecular weight than are found in temporary hair color dyes. These dyes are ...
The three compounds seriously discussed are ethylene, aniline, and dinitrophenol. Even at low levels, these organic chemical ... This phenomenon cuts off entry of carbon dioxide, thereby making the plant rely on stored compounds like sugar. If the heat ... Organic Air Pollutants: this subsection focuses on organic compounds. ... compounds have caused: abnormal dropping of foliage, twisted foliage, and killing of seedlings. This was proposed by Fritz Führ ...
Reduction of this nitro compound affords the aniline. Sulfonation with oleum gives 4-amino-5-methoxy-2-methylbenzenesulfonic ... The compound features both amine and methoxy functional groups. It is used as an intermediate in preparation of dyes and ... The compound is obtained in several steps from 4-chlorotoluene. Nitration gives mainly 3-nitro-4-chlorotoluene, which reacts ... para-Cresidine is an organic compound with the formula CH3OC6H3(CH3)NH2. It is a white solid that is soluble in organic ...
The resulting nitro compound is reduced to the aniline. Trimethylaniline is a building block to a variety of bulky ligands. ... 2,4,6-Trimethylaniline is an organic compound with formula (CH3)3C6H2NH2. It is an aromatic amine that is of commercial ... N-heterocyclic carbenes, as found in 2nd generation Grubbs' catalyst, are also prepared from this compound. Gerald Booth (2007 ... "Nitro Compounds, Aromatic". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a17_411. ...
The coupler compounds (couplers) are meta-substituted derivatives of aniline. They come in three major classes based on the ... 2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ... These compounds produce broad-band absorption when they react to form dyes, allowing for more natural-looking hair colors. The ...
... s (or phenylamides) are a class of chemical compounds which are acyl derivatives of aniline. Aniline reacts with acyl ... For example, reaction of aniline with acetyl chloride provides acetanilide (CH3-CO-NH-C6H5). At high temperatures, aniline and ...
... can degrade phenolic compounds and aniline, which are often pollutants of soil and water. Delftia ... "Degradation of Aniline by Delftia tsuruhatensis 14S in Batch and Continuous Processes". Applied Biochemistry and Microbiology. ...
... is the organic compound N,N-diethyl-p-(phenylazo)aniline. It is an azo dye, which has the appearance of a ... and to Aniline Yellow. It is used to dye hydrocarbon solvents, oils, fats, waxes (candles), notably petrol, mineral oil and ...
Polymerization of substituted anilines, phenols, and heterocyclic compounds by peroxidase in organic solvents. Columbus, Ohio: ... On the other hand, for an enzyme such as cytochrome c peroxidase, the compounds that donate electrons are very specific, due to ... Other studies have shown that peroxidases may be used successfully to polymerize anilines and phenols in organic solvent ... For example, horseradish peroxidase can use a variety of organic compounds as electron donors and acceptors. Horseradish ...
N,N-Dimethylaniline (DMA) is an organic chemical compound, a substituted derivative of aniline. It consists of a tertiary amine ... DMA is also used as a precursor to other organic compounds. A study of the in vitro metabolism of N,N-dimethylaniline using ... 2007) "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry. John Wiley & Sons: New York. doi:10.1002/14356007.a02_303 ... DMA was first reported in 1850 by the German chemist A. W. Hofmann, who prepared it by heating aniline and iodomethane: C6H5NH2 ...
The reaction of the diazonium compound derived from aniline with hypophosphorus acid gives benzene. Trimerization of acetylene ... He gave the compound the name benzin. In 1836, the French chemist Auguste Laurent named the substance "phène"; this word has ... Many important chemical compounds are derived from benzene by replacing one or more of its hydrogen atoms with another ... The new understanding of benzene, and hence of all aromatic compounds, proved to be so important for both pure and applied ...
The compound is obtained by azo coupling of aniline and acetoacetanilide or their derivatives. The class of compounds was ... Arylide yellow, also known as Hansa yellow and monoazo yellow, is a family of organic compounds used as pigments. They are ... and aniline (acetoacetanilide precursor) to produce medium yellows. Pigment Yellow 3 (CAS# 6486-23-3), derived from 4-chloro-2- ...
... is a mild methylating agent, useful for dimethylation of anilines and related heterocyclic compounds. The ... It has some specialized uses in the production of other compounds. Trimethyl phosphate is prepared by treating phosphorus ... "Phosphorus Compounds, Organic" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2006. doi:10.1002/ ...
The compound is a derivative of aniline, consisting of an amine bound to two phenyl groups. The compound is a colorless solid, ... T. Kahl, K.-W. Schröder, F. R. Lawrence, W. J. Marshall, Hartmut Höke, Rudolf Jäckh, "Aniline" in Ullmann's Encyclopedia of ... Diphenylamine is manufactured by the thermal deamination of aniline over oxide catalysts: 2 C6H5NH2 → (C6H5)2NH + NH3 It is a ... Diphenylamine is an organic compound with the formula (C6H5)2NH. ... reflecting the antioxidant nature of aniline derivatives. Many ...
The Doebner-Miller reaction is the organic reaction of an aniline with α,β-unsaturated carbonyl compounds to form quinolines. ... Bergström, F. W. (1944). "Heterocyclic Nitrogen Compounds. Part IIA. Hexacyclic Compounds: Pyridine, Quinoline, and ... β-unsaturated carbonyl compound is prepared in situ from two carbonyl compounds (via an Aldol condensation), the reaction is ... elimination of one aniline molecule through 8 and rearomatization leads to final product 9. Because α-amino protons are not ...
Electron-rich aromatic compounds, such as phenols, anilines, and various aromatic heterocycles, can be brominated using NBS. ... Side reactions include the formation of α-bromoketones and dibromo compounds. These can be minimized by the use of freshly ... Bromination of unsaturated compounds with N-bromoacetamide, a contribution to the theory of the course of chemical processes]. ... "α-Halocarbonyl compounds. II. Position-specific preparation of α-bromoketones by bromination of lithium enolates. Position- ...
... s are chemical compounds which consist of an aniline ring substituted with two chlorine atoms and have the ... As aniline derivatives, they are named with the amino group in position 1. They are all colorless, although commercial samples ... Thomas Kahl, Kai-Wilfrid Schröder, F. R. Lawrence, W. J. Marshall, Hartmut Höke, Rudolf Jäckh "Aniline" in Ullmann's ...
However, the compound is bearing an aniline moiety known to be associated with risks of unpredictable idiosyncratic toxicity. ... Since then no additional compound was discovered by the company despite major investments and attempts with GKT-771, a compound ... which classify setanaxib has an aniline-based compound with a high risk of idiosyncratic toxicity particularly in a large ... The compound showed no effect in the 400 mg daily group and a very weak effect in the high dose group of twice 400 mg daily. ...
... is a chemical compound which is the amide of salicylic acid and aniline. It is classified as both a salicylamide ...
... (NMA) is an aniline derivative. It is an organic compound with the chemical formula C6H5NH(CH3). The substance ... Chemicals, such as methylal, aniline-type compounds, halogens and those containing phosphorus and silicon, etc. should not ... 0436". National Institute for Occupational Safety and Health (NIOSH). "Monomethyl aniline". Immediately Dangerous to Life or ...
The Bechamp reduction is used to reduce aromatic nitro compounds to their corresponding anilines, using iron and hydrochloric ... Tertiary aliphatic nitro compounds, however, are converted in good yield to the amine compound using the Bechamp reduction. The ... The Bechamp reduction is broadly applicable to aromatic nitro compounds. Aliphatic nitro compounds are however more difficult ... This reaction was originally used to produce large amounts of aniline for industry, but catalytic hydrogenation is the ...
... is a compound where an aniline molecule is substituted with a bromine atom on the para position. Commercially ... 4-bromoaniline can be made by reacting aniline with bromine with a protection with acetyl chloride. In the synthesis of ... "Studies on analgesics of aniline series. I. Preparation and properties of beta-alaninamide series". Chem Pharm Bull. 13: 198- ... available, this compound may be used as a building block, e.g. in the preparation of p-bromobiphenyl via the Gomberg-Bachmann ...
... (1,2-diphenylhydrazine) is an aromatic organic compound consisting of two aniline groups joined via their ...
It can also be used as a reducing agent, for example in the reduction of aromatic nitro compounds to anilines. The Cativa ... Lyday, Phyllis A. (2005). "Iodine and Iodine Compounds". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. ... "Simple and chemoselective reduction of aromatic nitro compounds to aromatic amines: reduction with hydriodic acid revisited". ...
Z.P. Liu; B.J. Wang; Y.H. Liu; S.J. Liu (May 2005). "Novosphingobium taihuense sp nov., a novel aromatic-compound-degrading ... aniline, nitrobenzene and phenanthrene. The species N. aromativorans, which was first found in Ulsan Bay, similarly degrades ... Novosphingobium is a genus of Gram-negative bacteria that includes N. taihuense, which can degrade aromatic compounds such as ...
The imine in this organic reaction is a condensation reaction product from an aniline type compound and a benzaldehyde type ... Treatment of these compounds with TBAF invokes a ring-expansion that provides the corresponding benzazepines. One variation of ... The reaction mechanism for the Povarov reaction to the quinoline is outlined in scheme 1. In step one aniline and benzaldehyde ... Scheme 4 depicts this 4 component reaction with the ethyl ester of glyoxylic acid, 3,4-dihydro-2H-pyran, aniline and ethanol ...
... compound F. Compound F continues to react with the palladium intermediate B, with regeneration of the copper halide, G. ... This coupling can be carried out starting from anilines by formation of the diazonium salt followed by in situ Sonogashira ... The active palladium catalyst is the 14 electron compound Pd0L2, complex A, which reacts with the aryl or vinyl halide in an ... In an inverse Sonogashira coupling the reactants are an aryl or vinyl compound and an alkynyl halide. While a copper co- ...
Reduction of nitro compounds Nitro compounds Can be accomplished with elemental zinc, tin or iron with an acid. ... Solvation effects also dominate the basicity of aromatic amines (anilines). For anilines, the lone pair of electrons on ... ˈæmiːn/,[1][2] UK also /ˈeɪmiːn/)[3] are compounds and functional groups that contain a basic nitrogen atom with a lone pair. ... Aryldiazonium couple with electron-rich aromatic compounds such as a phenol to form azo compounds. Such reactions are widely ...
Raymond S. Horvath (June 1972), Microbial Co-Metabolism and the Degradation of Organic Compounds in Nature, Bacteriological ...
The fact that picric acid gives a colorless solution in benzene which becomes yellow on adding aniline shows that picric acid ... and it provides a solvent in which organic compounds are soluble. The most commonly used procedure is the titration of organic ... is not dissociated in benzene solution and also that in the presence of the base aniline it functions as an acid, the ...
Related compounds. Nitrobenzene. Aniline Except where otherwise noted, data are given for materials in their standard state (at ... Nitrosobenzene is the organic compound with the formula C6H5NO. It is one of the prototypical organic nitroso compounds. It is ... Nitrosobenzene can also be prepared by oxidation of aniline using peroxymonosulfuric acid (Caro's acid)[5] or Oxone.[6] It is ... "Asymmetric O− and N− Nitroso Aldol Reaction - an efficient access to a-oxy and a-amino carbonyl compound" (PDF).. ...
... from aniline, which in turn could be easily obtained from coal tar; over the next ten years Perkin set up the first industrial ... that was the actual effective fraction of a traditional natural compound obtained by "soft" methods has been exemplary for the ...
P. M.F.J. Costa, U. K. Gautam, Y. Bando and D. Golberg : «The electrical delivery of a sublimable II-VI compound by vapor ... Bottom-Up Construction Size-Related Optical Extinction and Selective Aniline Trapping» Adv. Mater. 23[16] (2011) 1865-1870 DOI: ... G. Dmitri, Y. Bando, Z. Dong, C. TANG, Y. Uemura : «Structure transport and field-emission properties of compound nanotubes: ... G. Dmitri, Y. Bando, Z. Dong : «SyntesisAnalysisand Electrical Property Measurements of Compound Nanotubes in the B-C-N Cermaic ...
replacement of the aniline ring with any aromatic monocycle whether or not further substituted in or on the aromatic monocycle ... This is a list of fentanyl analogues, including both compounds developed by pharmaceutical companies for legitimate medical use ... a) an acetyl, propionyl, butenoyl or butanoyl radical, attached to the aniline nitrogen atom: (b) 1 or more alkyl radicals, ... "Fentanyl analogues, in which the N-[1-(2-phenethyl)-4-piperidyl]aniline nucleus has additional radicals, either alone or in ...
Nimesulide; Aminophenols (anilines): Acetanilide. *AM-404 (N-arachidonoylaminophenol). *Bucetin. *Paracetamol (acetaminophen). ... Isopropyl compounds. *Carboxamides. *Ethers. *Cardiovascular system drug stubs. Hidden categories: *CS1 German-language sources ...
Aromatic nitriles are often prepared in the laboratory from the aniline via diazonium compounds. This is the Sandmeyer reaction ... Organic compounds containing multiple nitrile groups are known as cyanocarbons. Inorganic compounds containing the −C≡N group ... A nitrile is any organic compound that has a −C≡N functional group.[1] The prefix cyano- is used interchangeably with the term ... The first compound of the homolog row of nitriles, the nitrile of formic acid, hydrogen cyanide was first synthesized by C. W. ...
Items listed in bold indicate initially developed compounds of specific groups. #WHO-EM †Withdrawn drugs. ‡Veterinary use ... Nimesulide; Aminophenols (anilines): Acetanilide. *AM-404 (N-arachidonoylaminophenol). *Bucetin. *Paracetamol (acetaminophen). ...
... is an organic compound with the formula (O2N)3C6H2OH. Its IUPAC name is 2,4,6-trinitrophenol (TNP). The name " ... Edison also manufactured aniline dyes, which previously had been supplied by the German dye trust. Other wartime products ... Like other highly nitrated organic compounds, picric acid is an explosive, hence its primary use. It has also been used in ... However, shells filled with picric acid become highly unstable if the compound reacts with metal shell or fuze casings to form ...
The coupler compounds (couplers) are meta-substituted derivatives of aniline. They come in three major classes based on the ... 2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ... These compounds produce broad-band absorption when they react to form dyes, allowing for more natural-looking hair colors. The ...
The dangers of compounds containing lead were well-established by then and Kettering was directly warned by Robert Wilson of ... aniline to 100-octane avgas.[60] By this time the Rolls-Royce Merlin 66 was developing 2,000 hp using this fuel. ... Oxygenate blending adds oxygen-bearing compounds such as MTBE, ETBE, ethanol and biobutanol. The presence of these oxygenates ... Quality gasoline should be stable for six months if stored properly, but as gasoline is a mixture rather than a single compound ...
a b Dichlorobenzidine - Compound Summary, PubChem. *^ a b c d e "NIOSH Pocket Guide to Chemical Hazards #0191". National ... 3,3'-Dichlorobenzidine is an organic compound with the formula (C6H3Cl(NH2))2. The pure compound is pale yellow, but commercial ... This article about an aromatic compound is a stub. You can help Wikipedia by expanding it.. *v ... Anilines. *Biphenyls. *Aromatic compound stubs. Hidden categories: *Articles without UNII source. *ECHA InfoCard ID from ...
... is an organic compound, which, especially in its ester form, is called fenamate.[1]:458 serves as a parent ... Nimesulide; Aminophenols (anilines): Acetanilide. *AM-404 (N-arachidonoylaminophenol). *Bucetin. *Paracetamol (acetaminophen). ... Items listed in bold indicate initially developed compounds of specific groups. #WHO-EM †Withdrawn drugs. ‡Veterinary use ...
After acetylation to 4.11 and inversion of configuration with added base DBN this problem was remedied in compound 4.12. Next ... aniline. These preambles facilitated the introduction of the final missing C20 fragment as the Grignard reagent ...
It is also one of the chemical compounds found in castoreum. This compound is gathered from the beaver's castor sacs.[31] ... Similarly diamines, useful in the rubber industry as antiozone agents, are produced similarly from aniline: C6H4(OH)2 + 2 C6H5 ... Hydroquinone, also known as benzene-1,4-diol or quinol, is an aromatic organic compound that is a type of phenol, a derivative ... Hubel, Karl; Braye, Henri (1960). Process for the preparation of substituted cyclic compounds and products resulting therefrom ...
Transition metal compounds. From left to right, aqueous solutions of: Co(NO. 3). 2 (red); K. 2Cr. 2O. 7 (orange); K. 2CrO. 4 ( ... The discovery in 1856 of mauveine, the first aniline dye, was a forerunner for the development of hundreds of synthetic dyes ... Vermilion, a toxic mercury compound favored for its deep red-orange color by old master painters such as Titian, has been ... Organic pigments such as diazo or phthalocyanine compounds feature conjugated systems of double bonds. Some inorganic pigments ...
Nitro compounds[edit]. The aliphatic nitro compounds normally show weak molecular ion peaks, while the aromatic nitro compounds ... For anilines, they prefer to lose a hydrogen atom before the expulsion of HCN. ... Carbonyl compounds[edit]. There are five types of carbonyl compounds, including aldehydes, ketones, carboxylic acids and esters ... For example, two compounds with identical mass of 150 Da, C8H12N3+ and C9H10O2+, will have two different M+2 intensities which ...
These compounds are potentially dangerous alkylating agents. Natural sulfate esters[edit]. The reduction of sulfate in nature ... Some organosulfates can be prepared by the Elbs persulfate oxidation of phenols and the Boyland-Sims oxidation of anilines. ... Organosulfates are a class of organic compounds sharing a common functional group commonly with the structure R-O-SO3−. The SO4 ... Many organisms utilize these reactions for metabolic purposes or for the biosynthesis of sulfur compounds required for life.[4] ...
Myers RL (30 August 2007). The 100 most important chemical compounds: a reference guide. ABC-CLIO. p. 10. ISBN 978-0-313-33758- ... Nimesulide; Aminophenols (anilines): Acetanilide. *AM-404 (N-arachidonoylaminophenol). *Bucetin. *Paracetamol (acetaminophen). ... Items listed in bold indicate initially developed compounds of specific groups. #WHO-EM †Withdrawn drugs. ‡Veterinary use ... other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897 ...
Diacylglycerol can be mimicked by the tumor-promoting compounds phorbol esters.[6] ... Nimesulide; Aminophenols (anilines): Acetanilide. *AM-404 (N-arachidonoylaminophenol). *Bucetin. *Paracetamol (acetaminophen). ...
Iodinated compounds may be dehalogenated as well, though the process may not satisfy the need for an electron acceptor.[5] ... has been shown to deactivate relatively persistent aniline-based herbicides far more rapidly than observed in aerobic ... Aromatic compounds are among the most persistent of these pollutants and lessons can be learned from the recent genomic studies ... Many synthetic steroidic compounds like some sexual hormones frequently appear in municipal and industrial wastewaters, acting ...
Aromatic compounds. Benzene is one of the best-known aromatic compounds as it is one of the simplest and most stable aromatics. ... Heterocycles are commonly found in a wide range of products including aniline dyes and medicines. Additionally, they are ... Aliphatic compounds. Main article: Aliphatic compound. The aliphatic hydrocarbons are subdivided into three groups of ... Converting individual petroleum compounds into different types of compounds by various chemical processes led to organic ...
Some chemical compounds made from petroleum are also obtained from other fossil fuels, such as coal or natural gas, or ... aniline - aminobenzene *methylene diphenyl diisocyanate (MDI) - used as a co-monomer with diols or polyols to form ... Formaldehyde Moulding Compound (FMC). n-Hexene. Linear alkyl benzene (LAB). Methanol. Methyl tert-butyl ether (MTBE) Phenol. ...
Schorlemmer, Carl (1874). A Manual of the Chemistry of the Carbon compounds; or, Organic Chemistry. London.. .mw-parser-output ... The synthesis of N-(2-carboxyphenyl)glycine from the easy to obtain aniline provided a new and economically attractive route. ... The molecule absorbs light in the orange part of the spectrum (λmax = 613 nm).[18] The compound owes its deep color to the ... The compound has been found to act as an agonist of the aryl hydrocarbon receptor.[23] ...
... anilines) or new carbon-oxygen bonds (aryloxy compounds). An example is the direct arylation of perfluorobenzenes [6] ... Aromatic compounds are those chemical compounds (most commonly organic) that contain one or more rings with pi electrons ... In contrast to compounds that exhibit aromaticity, aliphatic compounds lack this delocalization. The term "aromatic" was ... Examples of non-benzene compounds with aromatic properties are furan, a heterocyclic compound with a five-membered ring that ...
... aniline, polyester and nylon. The overwhelming majority of aromatic compounds are compounds of carbon, but they need not be ... Organic compounds that are not aromatic are classified as aliphatic compounds-they might be cyclic, but only aromatic rings ... Like neutral aromatic compounds, these compounds are stable and form easily. The cyclopentadienyl anion is formed very easily ... Aromaticity also occurs in compounds that are not carbocyclic or heterocyclic; inorganic six-membered-ring compounds analogous ...
Organic compounds[edit]. Additionally, there are environmental diseases caused by the aromatic carbon compounds including : ... aniline, trinitrophenylmethylnitramine (tetryl), hexanitrodiphenylamine (aurantia), phenylenediamines, and paraquat. ... The irritant gases are sulfur dioxide, ammonia, nitrogen dioxide, chlorine, phosgene, and fluorine and its compounds, which ... The aliphatic carbon compounds can also cause environmental disease. Included in these are methanol, nitroglycerine, ...
... and concrete surfaces contaminated with amine compounds (aniline) w... ... Aniline) by DeconGel 1101. AbstractSurface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, ... No comments were found for Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101. Be the first to comment! ... Aniline was chosen as a representative amine compounds (industrial plastics feedstock); DeconGel is expected to have similar ...
benzenetetraamine promotes the reaction [[Plant Extracts results in increased negative regulation of extracellular matrix disassembly] which results in increased negative regulation of cell motility ...
... and the properties of the title compounds are described. Analytical conductometric, spectral (infrared and ultraviolet) and ... Etherate, pyridine, and aniline compounds of the complex tri- and tetra-iodoacids of Zn(II) and Cd(II). ... The existence of metal-nitrogen bond for all pyridine and aniline complexes, except H2CdI4·4An (An=aniline), is adduced from ... The preparation, for the first time, and the properties of the title compounds are described. Analytical conductometric, ...
Title: Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds. ... "Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds". Germany. doi:10.1002/ ... title = {Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds},. author = { ... Mesoporous Manganese Oxide Catalyzed Aerobic Oxidative Coupling of Anilines To Aromatic Azo Compounds ...
It is observed in these compounds case as in other LC compounds Vuks isotropic model is favored compared to that of anisotropic ... p-n-alkoxy anilines, 2O.Om with m = 3 to 10 liquid crystalline compounds except with m = 5 which has been already published. ... The rest of the compounds exhibit the nematic LC phase except with m = 10 which shows the smectic-C phase along the nematic ... nO.m and nO.Om compounds play an important role in the fundamental and applied aspects. As a part of our systematic studies of ...
... B. J. Aylett, M. J. Hakim*Journal of the Chemical Society ...
... aniline Precursor products, 3-(Trifluoromethylthio)aniline Downstream products ect. ... Current Page: Home › Chemical Dictionary › 369-68-6 › 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Products ... 3-(Trifluoromethylthio)aniline 369-68-6 Precursor and Downstream Products Precursor:. 404-74-0 79576-16-2 370-47-8 90109-81-2 ...
Book; Format: print Publisher: London : Monitoring and Assessment Research Centre, 1986Availability: Items available for loan: WHO HQ [Call number: QV 632 86HE] (1). Withdrawn (1). ...
Surface Decontamination of Amine Compounds (Aniline) by DeconGel 1101 Abstract Surface decontamination efficacy determination ... Surface Decontamination of Cadmium Compounds (Cadmium Chloride (CdCl2) and Cadmium Oxide (CdO)) by DeconGel 1101 OBJECTIVE The ... Surface Decontamination of Cyanide Compounds (Potassium Ferricyanide (K3[Fe(CN)6])) by DeconGel 1101 ABSTRACT Surface ... Surface Decontamination of Tin compounds (tributyltin chloride) by DeconGel 1101 Abstract Surface decontamination efficacy of ...
Vilesov, F.I.; Terenin, A.N., The photoionization of the vapors of certain organic compounds, Dokl. Akad. Nauk SSSR, 1957, 115 ... Meek, J.T.; Sekreta, E.; Wilson, W.; Viswanathan, K.S.; Reilly, J.P., The laser photoelectron spectrum of gas phase aniline, J ... Palmer, M.H.; Moyes, W.; Spiers, M.; Ridyard, J.N.A., The electronic structure of substituted benzenes; a study of aniline, the ... Smith, M.A.; Hager, J.W.; Wallace, S.C., Two color photoionization spectroscopy of jet cooled aniline: Vibrational frequencies ...
Aniline Compounds are organic compounds, consisting of a phenyl group attached to an amine group, with a molecular formula ( ... Aniline and substituted Anilines Compounds. "Aniline Compounds (aminobenzenes)" Aniline and substituted Anilines Compounds. In ... Aniline Compounds. In organic chemistry, Aniline Compounds, as organic compounds, consisting of a phenyl group attached to an ... As an aniline compound, Anilides are any aromatic amides obtained by acylation of aniline. Examples of anilide compounds ...
Compounds with aniline or phenol moieties represent two large classes of frequently skin sensitizing chemicals but exhibiting ... Then the model was utilized to analyze a subset of FDA approved drugs containing aniline and/or phenol groups for prediction of ... The model was further applied to predict allergic potential of a subset of FDA approved drugs containing aniline and/or phenol ... A group of mechanistically hard-to-be-classified aniline and phenol chemicals were collected. An in silico model was ...
Aniline Compounds * Radiopharmaceuticals * Thiazoles Grant support * R37 AG025516/AG/NIA NIH HHS/United States ... Pittsburgh compound B (PiB) is a noninvasive in vivo positron emission tomography tracer used to image amyloid deposition in ... Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B Alzheimers Dement. 2012 Nov;8( ...
Aniline Compounds * Biomarkers / metabolism * Carbolines / metabolism* * Cerebral Cortex / metabolism* * Cognitive Dysfunction ... C Pittsburgh compound B (PiB) in older clinically normal individuals, and symptomatic patients with mild cognitive impairment ...
... bladder cancer in dye workers exposed to aniline compounds; leukemia and lymphoma in chemical workers exposed to benzene; ... more quickly after the introduction of new chemical compounds, and in more severe forms. ...
Aniline is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is ... In commerce, three brands of aniline are distinguished: aniline oil for blue, which is pure aniline; aniline oil for red, a ... Aniline is a weak base. Aromatic amines such as aniline are, in general, much weaker bases than aliphatic amines. Aniline ... "ANILINE , CAMEO Chemicals , NOAA". cameochemicals.noaa.gov. Retrieved 2016-06-16.. *^ a b c d e f Kahl, Thomas; Schröder, Kai- ...
What is the IUPAC name for the compound a. aminobenzene b. benzoamine c. aniline d. no correct response. Organic And Biological ... A chemical bond is formed due to the attraction between the atoms that lead to the formation of a compound or a molecule. ...
The coupler compounds (couplers) are meta-substituted derivatives of aniline. They come in three major classes based on the ... 2) Reaction of this diimine with a coupler compound (more detail below). 3) Oxidation of the resulting compound to give the ... Couplers are chemical compounds that define the color of the hair dye. Shown here are three red couplers (A, B, C), two yellow- ... These compounds produce broad-band absorption when they react to form dyes, allowing for more natural-looking hair colors. The ...
0 (AKB-9778); 0 (Angiopoietin-1); 0 (Angiopoietin-2); 0 (Aniline Compounds); 0 (Sulfonic Acids); 0 (Vascular Endothelial Growth ...
0 (2-methyl-4-(N-propyl-N-cycloproanemethylamino)-5-chloro-6-(2,4,6-trichloranilino)pyrimidine); 0 (Aniline Compounds); 0 (CRF ...
0/Aniline Compounds; 0/Ferric Compounds; 0/Manganese Compounds; 0/Polychlorinated Biphenyls; 0/Silicates; 0/Soil; 0/Soil ... Aniline Compounds / chemistry*. Catalysis. Environmental Pollution / prevention & control. Ferric Compounds. Ferritins / ... Manganese Compounds / chemistry. Pentachlorophenol / chemistry*. Polychlorinated Biphenyls / chemistry*. Silicates / chemistry ... The efficiency of the mechanochemical removal was compared with batch experiments for the soluble compounds (PCP and 4-CA). The ...
... alkyl diblock compound was designed, synthesized and fully characterized. By employing suitable conditions, doped, ... A tetra(aniline)-alkyl diblock compound was designed, synthesized and fully characterized. By employing suitable conditions, ... Block-like electroactive oligo(aniline)s: anisotropic structures with anisotropic function† Zhecheng Shao,‡a Zai Yu,‡bd ... Block-like electroactive oligo(aniline)s: anisotropic structures with anisotropic function Z. Shao, Z. Yu, J. Hu, S. ...
Aniline Compounds. 2. 2010. 853. 0.340. Why? Technetium Tc 99m Sestamibi. 4. 1997. 192. 0.340. Why? ...
Reduction of this nitro compound affords the aniline. Sulfonation with oleum gives 4-amino-5-methoxy-2-methylbenzenesulfonic ... The compound features both amine and methoxy functional groups. It is used as an intermediate in preparation of dyes and ... The compound is obtained in several steps from 4-chlorotoluene. Nitration gives mainly 3-nitro-4-chlorotoluene, which reacts ... para-Cresidine is an organic compound with the formula CH3OC6H3(CH3)NH2. It is a white solid that is soluble in organic ...
Aniline Compounds [‎1]‎. Anniversaries and Special Events [‎2]‎. Anopheles [‎2]‎. Antarctic Regions [‎1]‎. ...
9.2.2.10.5. 2.2.10.5 Aniline Compounds. 9.2.2.10.6. 2.2.10.6 Azides ...
NIOSH-Author; Carcinogens; Anilines; Chlorine-compounds; Amines; Protein-biochemistry; Oxidative-phosphorylation; Arylamines ...
NIOSH-Author; In-vivo-studies; Laboratory-animals; Anilines; Organo-chlorine-compounds; Chemical-binding; Nucleic-acids; ...
  • Like other amines, aniline is a base (p K aH = 4.6) and nucleophile, although it is a weaker base and poorer nucleophile than structurally similar aliphatic amines. (wikipedia.org)
  • Aromatic amines such as aniline are, in general, much weaker bases than aliphatic amines. (bionity.com)
  • Aniline combines directly with alkyl iodides to form secondary and tertiary amines. (bionity.com)
  • In this work, we propose a protocol to produce methyl-substituted amines by the selective reaction of the methoxy groups of lignin and aniline compounds. (rsc.org)
  • Some aromatic amines, hydrazine and related substances, N-nitroso compounds and miscellaneous alkylating agents. (ilo.org)
  • Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Biochemi. (chemnet.com)
  • The figures below show the boiling and melting point for organic nitrogen compounds as amines, diamines, pyrroles, pyridines, piperidines and quinolines , together with the molecular structures of the different compounds. (engineeringtoolbox.com)
  • For the purposes of this study, aniline and other nitrogen compounds not listed among the products specified above are excluded, although they are sometimes considered amines. (prweb.com)
  • These are compound amines, bodies of the. (google.com)
  • Examples of these compounds include anilines/amines, halogenated aromatics, and ethers. (europa.eu)
  • Phosgene in the air may also react with compounds like dyes and pesticides, so workers employed in moisture in clouds or rain and be broken down into other these fields may be exposed to this compound. (cdc.gov)
  • 4-Methoxy-2-nitroaniline is an aniline compound used in the synthesis of dyes and pigments. (alfa.com)
  • Also used as an intermediate for the synthesis of dyes, pigments and other chemical compounds. (alfa.com)
  • My simple, and probably incorrect, understanding is that the dyes in FP ink are based on aniline dyes. (fountainpennetwork.com)
  • If there are any organic chemists out there, can you synthesise aniline dyes, or their functional equivalents, from organically grown fruit and vegies? (fountainpennetwork.com)
  • Leaving out artificial alizarin and indigo at present, these colours may be arranged in three divisions: (1) Aniline Dyes. (google.com)
  • Victor Meyer type nucleophilic substitution reactions with organobromides or organoiodides forming nitro compounds. (wikipedia.org)
  • Notable examples include: The production of aniline compounds. (wikipedia.org)
  • In organic chemistry, Aniline and substituted Anilines Compounds , aka aminobenzenes , are subclass of organic compounds belonging to the benzene and benzene substituted derivatives class in the benzenoid superclass , containing an aminobenzene moiety. (wellnessadvocate.com)
  • Benzene, GR ACS is an organic compound that is naturally found in crude oil and when refined is a colorless and highly flammable hydrocarbon. (spectrumchemical.com)
  • As an aniline compound , Anilides are any aromatic amides obtained by acylation of aniline. (wellnessadvocate.com)
  • Aniline reacts with carboxylic acids [2] or more readily with acyl chlorides such as acetyl chloride to give amides. (bionity.com)
  • The amides formed from aniline are sometimes called anilides , for example CH 3 -CO-NH-C 6 H 5 is acetanilide. (bionity.com)
  • The reference compound aniline shohed 74 % degradation after 14 days. (europa.eu)
  • At >0.3 mg/L cetyltrimethylammonium bromide (CTAB) negatively impacted degradation of the reference compound aniline. (americanelements.com)
  • The existence of metal-nitrogen bond for all pyridine and aniline complexes, except H 2 CdI 4 ·4 An ( An =aniline), is adduced from infrared and far infrared spectral studies. (springer.com)
  • Silicon-nitrogen compounds. (growkudos.com)
  • Aniline is a slightly pyramidalized molecule, with hybridization of the nitrogen somewhere between sp 3 and sp 2 . (wikipedia.org)
  • Reaction of formaldehyde with nitrogen dioxide, nitromethane, perchloric acid and aniline, or peroxyformic acid yields explosive compounds. (osha.gov)
  • Formaldehyde reacts with nitrogen dioxide, nitromethane, perchloric acid and aniline, or peroxyformic acid to yield explosive compounds. (osha.gov)
  • Many derivatives of aniline can be prepared in similar fashion. (bionity.com)
  • Aniline is a volatile aromatic amine used mainly as a chemical feedstock to produce plastics including polyurethane, and used as a rubber additive. (environmental-expert.com)
  • By definition, organic compounds contain the element carbon, and exhibit similar chemical properties, which is advantageous from a monitoring perspective. (environmental-expert.com)
  • Considering the existence of vast compounds around today, developing rapid and effective methods for chemical sensitizer identification/risk assessment is still a challenge [ 2 ]. (biomedcentral.com)
  • A chemical bond is formed due to the attraction between the atoms that lead to the formation of a compound or a molecule. (bartleby.com)
  • The dyeing of hair is an ancient art that involves treatment of the hair with various chemical compounds. (wikipedia.org)
  • Provides comprehensive data for each element of the periodic table of elements including up to 40 properties, names in 10 languages and common chemical compounds. (environmentalchemistry.com)
  • Aromatics are organic chemical compounds that are characterized by circular planar conjugated ring structures and are known for their flexible and useful chemical properties. (bccresearch.com)
  • This 2 g bottle of silver nitrate, also known as lunar caustic, is an inorganic compound with the chemical formula AgNO 3. (almodarresi.com)
  • Type of substance Composition: mono-constituent substance Origin: inorganic Total tonnage band Total range: 1 000 - 10 000 tonnes per annum REACH Silver nitrate is a chemical compound. (almodarresi.com)
  • Chemical Compounds are of two types. (almodarresi.com)
  • Silver nitrate is a caustic chemical compound with the formula AgNO 3. (almodarresi.com)
  • IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. (statemaster.com)
  • CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. (statemaster.com)
  • A chemical formula is an easy way of expressing information about the atoms that constitute a particular chemical compound. (statemaster.com)
  • Compound groups are groups of chemicals that share structural or chemical features. (pharosproject.net)
  • In organic chemistry, Anilides are organic heterocyclic compounds derived from oxoacids RkE(=O)l(OH)m (l not 0) by replacing an OH group by the NHPh group or derivative formed by ring substitution. (wellnessadvocate.com)
  • Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. (drugbank.ca)
  • Aniline, Reagent, ACS also known as phenylamine or aminobenzene is a toxic organic compound. (spectrumchemical.com)
  • Compounds with aniline or phenol moieties represent two large classes of frequently skin sensitizing chemicals but exhibiting very variable, and difficult to predict, potency. (biomedcentral.com)
  • A group of mechanistically hard-to-be-classified aniline and phenol chemicals were collected. (biomedcentral.com)
  • Then the model was utilized to analyze a subset of FDA approved drugs containing aniline and/or phenol groups for prediction of their skin sensitization potential. (biomedcentral.com)
  • The model was further applied to predict allergic potential of a subset of FDA approved drugs containing aniline and/or phenol moiety. (biomedcentral.com)
  • An accurate and simple quantum mechanistic model has been developed to predict the skin sensitization potential of mechanistically hard-to-be-classified aniline and phenol chemicals. (biomedcentral.com)
  • As an alternative, aniline is also prepared from phenol and ammonia, the phenol being derived from cumene. (bionity.com)
  • Numerous nucleophiles could be used by the enzyme as cosubstrates, aniline, pyridine, and 2-mercaptoethanol being the best among compounds tested. (springer.com)
  • Organic compounds are the basis for the molecules of life, like carbohydrates, fats (lipids), proteins, and nucleic acids. (fishersci.com)
  • Chromic acid converts it into quinone, whereas chlorates, in the presence of certain metallic salts (especially of vanadium ), give aniline black. (bionity.com)
  • Compounds of the formula (I) or salts thereof, wherein R1 represents alkyl, aryl, alkyl-aryl or aryl-alkyl, compositions containing same, and their use in counteracting human axillary malodour. (sumobrain.com)
  • The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. (google.com)
  • Likewise, it is also prone to oxidation: while freshly purified aniline is an almost colorless oil, exposure to air results in gradual darkening of the sample (to yellow or red) due to the formation of strongly colored, oxidized impurities. (wikipedia.org)
  • Aniline is colorless, but it slowly oxidizes and resinifies in air, giving a red-brown tint to aged samples. (drugbank.ca)
  • The oxidation of aniline has been carefully investigated. (bionity.com)
  • At sufficiently high anodic potential, the sulfonated aniline derivatives undergo oxidation processes yielding cation-radical and dimer intermediates, but no polymer deposition was observed on the working electrode surface. (hindawi.com)
  • An EC mechanism for electrooxidation of N- substituted anilines based by in situ UV-Vis spectroelectroscopy had been proposed [ 5 - 8 ], and based on this mechanism it had been reported that the formation of primary radical cation is the rate-limiting step in electrochemical oxidation of aniline. (hindawi.com)
  • It is used as a mild methylating reagent which is used in the dimethylation of aniline and related heterocyclic compound. (alfa.com)
  • CH9620626 Hydrogen Bonding in Organic Compounds. (publish.csiro.au)
  • A tetrakisazo compound represented by the following formula (1) in the free acid form: ##STR1## wherein Q1 and Q2 independently represent phenylene or naphthylene group which may be optionally substituted, R4, R5 and R6 independently represent a hydrogen atom, a halogen atom, a hydroxy group, a sulfonic. (google.com)
  • Organic compounds are, at the most basic level, compounds that contain carbon and hydrogen. (fishersci.com)
  • The simplest organic compound is methane, which contains one carbon atom covalently bonded to four hydrogen atoms. (fishersci.com)
  • Organic compounds are divided into two main groups: hydrocarbons, which comprise compounds that contain only carbon and hydrogen atoms, and a second type defined by a functional group that has replaced one of the hydrogen atoms in the molecule. (fishersci.com)
  • Soil column was equipped with the sediments and aquifer media collected from Weihe Riverbed and its bank, and was used to research the characteristics of aniline degradation in the riverbank filtration under sulfate-reducing conditions. (witpress.com)
  • The aniline degradation and sulfate reducing produce some intermediates, some of which are harmful to sulfate-reducing microorganisms. (witpress.com)
  • However, in deep, anaerobic sediments, aniline degradation is much slower and its half-life is approximately 10 years [1]. (witpress.com)
  • As a part of our systematic studies of the above homologous series regarding the synthesis, characterization and phase transition studies, here the authors report the polarizabilities and orientational order parameter, S in N-(p-n-ethoxybenzylidene)-p-n-alkoxy anilines, 2O.Om with m = 3 to 10 liquid crystalline compounds except with m = 5 which has been already published. (scirp.org)
  • In the second step, the nitrobenzene is hydrogenated, typically at 600 °C in presence of a nickel catalyst to give aniline. (bionity.com)
  • Potassium permanganate in neutral solution oxidizes it to nitrobenzene , in alkaline solution to azobenzene, ammonia and oxalic acid, in acid solution to aniline black. (bionity.com)
  • Aniline can be diazotized to give a diazonium salt, which can then undergo various nucleophilic substitution reactions. (wikipedia.org)
  • Victor Meyer type nucleophilic substitution reactions with organobromides or â ¦ Most silver compounds do not dissolve in water. (almodarresi.com)
  • The main components of fossil fuels (petroleum and natural gas) are a class of organic compounds known as hydrocarbons. (fishersci.com)
  • NHFG compounds are those that do not have any heteroatoms that can undergo hydrolysis over the pH range of 5 to 9 at 25 °C. Examples include xylenes, carboxylic acids, and polycyclic aromatic hydrocarbons (PAHs), 2. (europa.eu)
  • Experimental results showed that both aniline derivatives are electroactive compounds exhibiting redox behaviour in the range of potential of −0.2 V-1.6 V. Due to the self-doping effect induced by sulfonic groups, AnPS and DAnPS compounds have good electroactivity even in neat water solution. (hindawi.com)
  • Electrochemical studies on these compounds reveal that redox behaviour of the iron centre is influenced by the position imine or amine groups. (scielo.org.za)
  • Compound groups are useful because in some cases, lists will instead identify a group of structurally similar compounds (such as lead compounds) as all having the same hazard. (pharosproject.net)
  • Isomerism is the phenomenon whereby certain compounds, with the same molecular formula, exist in different forms owing to their different organisations of atoms. (etoosindia.com)
  • Compounds or allotropes of carbon that contain only carbon atoms are classified as inorganic compounds and exhibit novel properties. (fishersci.com)
  • 9 Generally, studies on ferrocene revolve around generation of compounds that are used in materials science, 10 electrochemistry 11,12 catalysis, 13-15 medicinal applications 16-24 and nonlinear optics 25,26 amongst others. (scielo.org.za)
  • In fact, the majority of elements in the periodic table of elements are inorganic compounds. (fishersci.com)
  • The desired compound has a chlorine in the meta position. (coursehero.com)
  • It ignites readily, burning with a smoky flame characteristic of aromatic compounds. (wikipedia.org)
  • The advances in Metabolic Engineering and Bioprocess Optimization have helped in enhancing the microbial conversion rate of biomass into aromatic compounds, which was expensive in the past. (bccresearch.com)
  • The molecular formula of the compounds is given below. (scirp.org)
  • In organic chemistry, Aniline Compounds , as organic compounds , consisting of a phenyl group attached to an amine group, with a molecular formula (C 6 H 5 NH 2 ). (wellnessadvocate.com)
  • Aniline is an organic compound with the formula C 6 H 5 NH 2 . (wikipedia.org)
  • Silver nitrite is an inorganic compound with the formula AgNO2. (wikipedia.org)
  • Disclosed in the present invention is an arylurea compound represented by formula I, or a pharmaceutically acceptable salt, a polymorph, a solvate or a stereoisomer thereof, and an intermediate and use thereof. (sumobrain.com)
  • The present invention relates to compounds 1, 1a (S-enantiomer) and 1b (R-enantiomer) of the following formula 1, and a method for preparing the same. (sumobrain.com)
  • formula 1] The novel compound of the formula 1 is used as an important intermediate f. (sumobrain.com)
  • The present invention comprises a compound of a compound of Formula 1 wherein Rf is a C2 to C-12 perfluoroalkyl optionally interrupted by one to four moieties each independently selected from the group consisting of -CH2-, -O-, -S-, -S(O. (sumobrain.com)
  • The present invention provides a pest control agent, an acaricide, or a bactericide that contains, as the active ingredient thereof, at least one type of compound selected from aryloxyurea compounds represented by formula (V) (wherein R1. (sumobrain.com)
  • The invention relates to new compounds of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them. (sumobrain.com)
  • The invention relates to novel compounds derived from amino acids of formula (I) and also to cosmetic or dermatological compositions containing them and to their use as agents for treating human perspiration in a cosmetic composition. (sumobrain.com)
  • Silver nitrate is an ionic compound, or salt, with the formula AgNO3. (almodarresi.com)
  • The compounds of formula 1 inhibit the tyrosine kinase activity of vekstftdctorreseptorer such herein, HER2 and HER4 thereby making them useful as antiproliferative agents. (google.com)
  • The compounds of formula 1 are also useful for treating other diseases associated with signal transduction pathways operating through vekstfakiorreseptorer. (google.com)
  • 5. A tetrakisazo compound represented by the following formula (5) in the free acid form: ##STR27## or a salt thereof. (google.com)
  • Anilino Naphthalenesulfonates are an aniline compound class of organic naphthalenesulfonate compounds , which contain an anilino (phenylamino) group linked to a salt or ester of naphthalenesulfonic acid. (wellnessadvocate.com)
  • Surface decontamination efficacy determination of DeconGelTM 1101 on stainless steel, aluminum, and concrete surfaces contaminated with amine compounds (aniline) was performed using GC/MS (Gas Chromatography/Mass Spectrometry) according to Environmental Protection Agency (EPA) SW-846 Methods: 3500C (Sampling) and 8270C (Analysis). (environmental-expert.com)
  • Excellent surface decontamination was achieved by applying DeconGel 1101 onto surfaces contaminated with amine compounds (Aniline) resulting in encapsulation of contaminants by DeconGel's active components. (environmental-expert.com)
  • Optimized experimental and analytical methods were successfully developed following standardized EPA sampling and analysis methods as guidelines for determination of organic compounds dissolved in a suitable solvent able to completely solvate aniline as well as DeconGel components. (environmental-expert.com)
  • Methods to predict the hydrolysis rates of organic compounds for use in the environmental assessment of pollutants have not advanced significantly since the early 80s of the 20th century. (europa.eu)
  • To develop such predictive methods, one needs a set of rate constants for a series of compounds that have systematic variations in structure and a database of molecular descriptors related to the substituents on the reactant molecule. (europa.eu)
  • The respective p-n ethyloxy benzaldehyde and the corresponding alkoxy anilines are taken in equi-molar proportions in absolute ethanol and refluxed for four hours in the presence of few drops of glacial acetic acid. (scirp.org)
  • Antifebrin (acetanilide), an anti-pyretic and analgesic, is obtained by the reaction of acetic acid and aniline. (bionity.com)
  • The oligomers are prepared by reacting tetraamines, diaminodiols, or diaminothiols (i.e. four-functional compounds) with poly-carboxylic acid halides, and crosslinking phenylimide end cap monomers in a suitable solvent under an inert atmosphere. (google.es)
  • a compound formed by the condensation of an alcohol and an acid, with elimination of water. (absp.org.uk)
  • a golden-yellow crystalline compound usually prepared by oxidizing aniline. (absp.org.uk)
  • Some preliminary examples of hydrolysis reactions illustrate the very wide range of reactivity of organic compounds. (europa.eu)
  • Because of the almost infinite number of ways in which carbon can bond with carbon and other elements, it's no surprise that about 95 percent of the millions of known compounds are organics with highly diverse structures. (fishersci.com)
  • Because of the large number of organic compounds and the diversity of their structures and reactivity, it often is not possible to use the more precise and reliable QSARs to estimate hydrolysis rates (Karickhoff et al. (europa.eu)
  • A tetra(aniline)-alkyl diblock compound was designed, synthesized and fully characterized. (rsc.org)
  • Often this can be done by comparison to the known reactions of similar compounds in the same class (i.e., having the same functional groups). (europa.eu)
  • The liquid had splendid antiknock qualities but a complete analysis showed the material contained tetraethyl lead, a recognized anti-knock compound, which the "inventor" had secretly added to his mixture. (modernmechanix.com)
  • We evaluated the duration of the drug effect after washing away free compound and found that the rate of recovery of receptor phosphorylation in the tumor cells reflected the inhibitor off-rate from the purified intracellular domain. (aacrjournals.org)
  • One such compound, 11[beta] -dichloro links an aniline mustard moiety to a steroid ligand for the androgen receptor (AR). (mit.edu)
  • and aniline oil for safranine, which contains aniline and ortho-toluidine, and is obtained from the distillate (échappés) of the fuchsine fusion. (bionity.com)
  • Monomethyl and dimethyl aniline are colourless liquids prepared by heating aniline, aniline hydro-chloride and methyl alcohol in an autoclave at 220 °C. They are of great importance in the colour industry. (bionity.com)
  • Iwata, S. , Ionization energies, Ab initio assignments, and valence electronic structure for 200 molecules in Handbook of HeI Photoelectron Spectra of Fundamental Organic Compounds , Japan Scientific Soc. (nist.gov)