Allylamine
Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways. (1/748)
Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer. To determine the molecular mechanism(s) of androgen-independent regulation of the PSA gene, the possibility that the androgen receptor (AR) is activated in the absence of androgen by stimulation of protein kinase A (PKA) was investigated. Activation of PKA by forskolin resulted in elevated expression of the PSA gene in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen, bicalutamide. Further evidence that induction of PSA gene expression was dependent on AR was obtained from experiments using PC3 cells devoid of AR. Neither PSA, PB, nor ARR3 androgen-responsive reporters could be induced by activation of PKA in the absence of transfected AR. In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Lastly, cotransfection of an expression vector for a chimeric protein encoding the amino-terminal domain of the human AR linked to Gal4 and a 5xGal4UAS reporter gene construct resulted in activation of the amino-terminal domain of the AR by stimulation of PKA activity. These results demonstrate androgen-independent induction of PSA gene expression in prostate cancer cells by an AR-dependent pathway. (+info)Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (2/748)
We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver. (+info)Metabolism of aminoacyl-p-nitroanilides by rat mammary tissue. (3/748)
We have examined the metabolism of aminoacyl-p-nitroanilides by rat mammary tissue isolated from rats during late pregnancy, peak lactation and late lactation. The rate of hydrolysis depended upon the chemical nature of the aminoacyl-p-nitroanilide compound and the physiological state of the donor animals. Thus, mammary tissue isolated from rats during late pregnancy and peak lactation hydrolysed aminoacyl-p-nitroanilides in the order L-met-p-nitroanilide=L-leu-p-nitroanilide>L-lys-p-nitroanilide>gamma- glu-p-nitroanilide. The order of activity was the same for mammary tissue taken from rats during late lactation except that L-lys-p-nitroanilide was hydrolysed at the same rate as the neutral aminoacyl-p-nitroanilides. Mammary tissue from peak lactating rats also hydrolysed alpha-L-glu-p-nitroanilide and alpha-L-asp-p-nitroanilide but to a lesser extent than the other compounds tested. The anionic aminoacyl-p-nitroanilides were able to trans-stimulate D-aspartate efflux from mammary tissue explants and the perfused mammary gland via the high-affinity anionic amino acid carrier. The clearance of gly-L-phe by the perfused mammary gland was markedly inhibited by L-phe. The results suggest that mammary tissue expresses a variety of dipeptidases at the basolateral aspect of the mammary epithelium which are capable of hydrolysing peptides extracellularly. These enzymes may be important for providing amino acids for milk protein synthesis and/or inactivating signal peptides. (+info)Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. (4/748)
The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR transcripts and genes from a large series of bone marrow metastases. Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by flutamide. In contrast, the single mutant AR found among 17 patients treated with androgen ablation monotherapy was not flutamide stimulated. Patients with flutamide-stimulated AR mutations responded to subsequent treatment with bicalutamide, an AR antagonist that blocks the mutant ARs. These findings demonstrate that AR mutations occur in response to strong selective pressure from flutamide treatment. (+info)Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. (5/748)
Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the development of therapy-resistant tumours, we established a new tumour model which closely resembles the situation in patients who receive androgen ablation therapy. Androgen-sensitive LNCaP cells were kept in androgen-depleted medium for 87 passages. The new LNCaP cell subline established in this manner, LNCaP-abl, displayed a hypersensitive biphasic proliferative response to androgen until passage 75. Maximal proliferation of LNCaP-abl cells was achieved at 0.001 nM of the synthetic androgen methyltrienolone (R1881), whereas 0.01 nM of this compound induced the same effect in parental cells. At later passages (> 75), androgen exerted an inhibitory effect on growth of LNCaP-abl cells. The non-steroidal anti-androgen bicalutamide stimulated proliferation of LNCaP-abl cells. AR protein expression in LNCaP-abl cells increased approximately fourfold. The basal AR transcriptional activity was 30-fold higher in LNCaP-abl than in LNCaP cells. R1881 stimulated reporter gene activity in LNCaP-abl cells even at 0.01 nM, whereas 0.1 nM of R1881 was needed for induction of the same level of reporter gene activity in LNCaP cells. Bicalutamide that acts as a pure antagonist in parental LNCaP cells showed agonistic effects on AR transactivation activity in LNCaP-abl cells and was not able to block the effects of androgen in these cells. The non-steroidal AR blocker hydroxyflutamide exerted stimulatory effects on AR activity in both LNCaP and LNCaP-abl cells; however, the induction of reporter gene activity by hydroxyflutamide was 2.4- to 4-fold higher in the LNCaP-abl subline. The changes in AR activity were associated neither with a new alteration in AR cDNA sequence nor with amplification of the AR gene. Growth of LNCaP-abl xenografts in nude mice was stimulated by bicalutamide and repressed by testosterone. In conclusion, our results show for the first time that the nonsteroidal anti-androgen bicalutamide acquires agonistic properties during long-term androgen ablation. These findings may have repercussions on the natural course of prostate cancer with androgen deprivation and on strategies of therapeutic intervention. (+info)Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat. (6/748)
The urinary metabolites of 3-methyl-4-trifluoromethylaniline in the rat were characterized and quantified using a combination of (19)F NMR, HPLC-NMR ((1)H and (19)F), and HPLC-mass spectrometry techniques. The major routes of metabolism were amine N-acetylation and methyl group C-oxidation to the benzyl alcohol (with subsequent glucuronide conjugation) and further to the corresponding benzoic acid derivative. Quantitatively only a small proportion of the urinary metabolites contained the free amino group, and these were products of ortho-hydroxylation (2 and 6 position) with additional conjugation to form the ether sulfates and glucuronides. An N-glucuronide of the parent compound was also identified. 3-Methyl-4-trifluoromethylacetanilide ((13)C-labeled in the acetyl group) gave virtually the same overall metabolite profile as 3-methyl-4-trifluoromethylaniline; however, a significant level of futile N-deacetylation and reacetylation occurred as ca. 50% of the excreted N-acetylated major metabolites contained no (13)C-label at the acetyl, having been replaced by an endogenous (12)C-acetyl source. This level of futile deacetylation is the highest yet reported for a substituted aniline/acetanilide and indicates a high degree of electronic activation of the amino group toward the acetyltransferase enzymes in vivo. (+info)Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: results of an Italian Prostate Cancer Project study. (7/748)
PURPOSE: To compare the efficacy of bicalutamide monotherapy to maximal androgen blockade (MAB) in the treatment of advanced prostatic cancer. PATIENTS AND METHODS: Previously untreated patients with histologically proven stage C or D disease (American Urological Association Staging System) were randomly allocated to receive either bicalutamide or MAB. After disease progression, patients treated with bicalutamide were assigned to castration. The primary end point for this trial was overall survival. Secondary end points included response to treatment, disease progression, treatment safety, quality-of-life (QOL), and sexual function. RESULTS: A total of 108 patients received bicalutamide and 112 received MAB. There was no difference in the percentage of patients whose prostate-specific antigen returned to normal levels. At the time of the present analysis (median follow-up time, 38 months; range, 1 to 60 months), 129 patients progressed and 89 died. There was no difference in the duration of either progression-free survival or overall survival. However, a survival trend favored bicalutamide in stage C disease but MAB in stage D disease. Overall and subgroup trends were confirmed by multivariate analysis. Serious adverse events and treatment discontinuations were more common in patients receiving MAB (P =.08 and P =.04, respectively). Fewer patients in the bicalutamide group complained of loss of libido (P =. 01) and of erectile dysfunction (P =.002). Significant trends favored bicalutamide-treated patients also with respect to their QOL, namely relative to social functioning, vitality, emotional well-being, and physical capacity. CONCLUSION: Bicalutamide monotherapy yielded comparable results relative to standard treatment with MAB, induced fewer side effects, and produced a better QOL. (+info)Stimulation of bradykinin B(1) receptors induces vasodilation in conductance and resistance coronary vessels in conscious dogs: comparison with B(2) receptor stimulation. (8/748)
BACKGROUND: Constitutive bradykinin B(1) receptors have been identified in dogs; however, their physiological implications involving the coronary circulation remain to be determined. This study examined, in conscious dogs, the coronary response to des-Arg(9)-bradykinin (a B(1) receptor agonist) and the mechanisms involved. METHODS AND RESULTS: Eleven dogs were instrumented with a left ventricular micromanometer, a circumflex coronary catheter, a cuff occluder, a Doppler flow probe, and ultrasonic crystals to measure coronary blood flow velocity (CBFv) and coronary diameter (CD). Intracoronary des-Arg(9)-bradykinin (3 to 100 ng/kg) and bradykinin (0.1 to 10 ng/kg) did not modify systemic hemodynamics but dose-dependently increased CBFv and CD. Des-Arg(9)-bradykinin was less potent than bradykinin. Hoe 140 (a B(2) antagonist, 10 microg/kg) abolished the effects of bradykinin but did not influence the effects of des-Arg(9)-bradykinin. When CBFv increase was prevented by the cuff occluder, CD responses to bradykinin and des-Arg(9)-bradykinin were maintained. Intracoronary lisinopril (0. 75 mg) increased the CD response to bradykinin, with only minimal effect on CBFv, and extended the duration of the effect. Lisinopril did not alter des-Arg(9)-bradykinin responses. Intracoronary N(omega)-nitro-L-arginine (2 mg/kg) decreased the CD effect of bradykinin and prevented the CBFv and CD effects of des-Arg(9)-bradykinin. The relaxing effect of des-Arg(9)-bradykinin on isolated coronary rings was prevented by des-Arg(9), [Leu(8)]-bradykinin. CONCLUSIONS: In the conscious dog, B(1) receptors are present in coronary vessels, and their stimulation produces vasodilation in conductance and resistance vessels, which is mediated essentially by NO but not modulated by angiotensin-converting enzyme. However, the coronary vasodilation induced by B(1) receptor stimulation is not as great as that produced by B(2) receptor stimulation. (+info)
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Anilide
Media related to Anilides at Wikimedia Commons v t e (Commons category link is on Wikidata, Articles with J9U identifiers, ... Anilides (or phenylamides) are a class of chemical compounds, which are amide derivatives of aniline. Aniline reacts with acyl ... 1, p. 82 "Anilide herbicides". Pesticide Target Interaction Database. East China University of Science & Technology. Archived ... Articles with LCCN identifiers, Articles with LNB identifiers, Anilides, All stub articles, Organic chemistry stubs). ...
Tocainide
1. Primary alpha-amino anilides". Journal of Medicinal Chemistry. 22 (10): 1171-6. doi:10.1021/jm00196a005. PMID 513064. Burton ... Anilides, All stub articles, Cardiovascular system drug stubs). ...
Oxycarboxin
It is an anilide. Oxycarboxin is used to control rust diseases (e.g. soybean rust). Oxycarboxin has been commercially available ... Anilides, Sulfones, Fungicides, All stub articles, Agriculture stubs, Heterocyclic compound stubs). ...
Flutamide
DE 2130450, Neri, Rudolph O. & Topliss, John G., "Substituierte Anilide [Substituted anilides]", published 1972-12-21, assigned ... Unlike the hormones with which it competes, flutamide is not a steroid; rather, it is a substituted anilide. Hence, it is ... Anilides, Anti-acne preparations, Aryl hydrocarbon receptor agonists, CYP17A1 inhibitors, Enantiopure drugs, Hair loss ...
Toxic oil syndrome
None of the in vivo or in vitro studies performed with toxic-oil-specific components, such as fatty acid anilides, and esters ... Similar results were obtained after administration of fatty acid anilides. Data discrepancies combined with both a high level ...
LiMAx test
Analgesic potency and acute toxicity of substituted anilides and benzamides. Toxicology and Applied Pharmacology 1971;19(1):20- ...
2,5-Furandicarboxylic acid
Screening studies on FDCA-derived anilides showed their important anti-bacterial action. The diacid itself is a strong ...
Aniline
The amides formed from aniline are sometimes called anilides, for example CH3−CO−NH−C6H5 is acetanilide. At high temperatures ... aniline and carboxylic acids react to give the anilides. N-Methylation of aniline with methanol at elevated temperatures over ...
Bicalutamide
It is a bicyclic compound (has two rings) and can be classified as and has variously been referred to as an anilide (N- ... First-generation NSAAs including bicalutamide, flutamide, and nilutamide are all synthetic, nonsteroidal anilide derivatives ... C]linically relevant antiandrogens currently are nonsteroidal anilide derivatives. Antiandrogens used for prostate cancer ... Anilides, Anti-acne preparations, Antiprogestogens, AstraZeneca brands, Benzonitriles, Benzosulfones, Bicalutamide, Hair loss ...
Naphthol AS
It is the anilide of 3-hydroxy-2-carboxynaphthalene. Many analogous compounds are known, designated with a differing suffix. ...
Aza-Cope rearrangement
Primary amines, aromatic amines, or lithium anilides can also be used as nucleophiles. Protective O-methylation often follows ...
1V-LSD
"Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O". The Journal of Organic ...
Salicylanilide
It is classified as both a salicylamide and an anilide. Derivatives of salicylanilide have a variety of pharmacological uses. ...
Portmanteau inhibitor
"Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5". Bioorganic & Medicinal ...
Meldrum's acid
A Neat Access to Anilides". ChemistrySelect. 2 (5): 1770-1773. doi:10.1002/slct.201601965. Davis, Garrett J.; Sofka, Holly A.; ...
Discovery and development of antiandrogens
... share an anilide ring structure. The structures can be seen in figure 7, where the anilide ring is coloured red. These three ... Replacing the anilide with an alkene gives weakly active compounds, which can be attributed to the lack of intramolecular ...
PMDTA
The effect of PMDTA on lithium anilide is illustrative of PMDTA's complexing power. The complex, [{PhN(H)Li}3·2PMDTA], is ... ISBN 978-3-527-29390-2. Barr, D.; Clegg, W.; Cowton, L.; Horsburgh, L.; Mackenzie, F. M.; Mulvey, R. (1995). "Lithium Anilide ...
Diampromide
Drugs not assigned an ATC code, Articles without KEGG source, Synthetic opioids, Propionamides, Anilides, Mu-opioid receptor ...
Meta-selective C-H functionalization
In 2009, Gaunt's group reported a copper catalyzed meta-selective C-H arylation reaction on anilide derivatives. Despite the ... It is compatible with a spectrum of substituted anilide as well as different bisaryliodonium salts. However, the meta- ... selectivity is lost when highly ortho/para-directing methoxy group substitutes one of the meta-hydrogen of the anilide, which ... the arylation occurs exclusively on the meta position on a variety of anilide substrates. Remarkably, the regioselectivity is ...
Arsanilic acid
... as arsenic acid anilide. Also biologist, physician, and pharmacist, Béchamp reported it 40 to 50 times less toxic as a drug ... "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique". Compt. Rend. 56: ...
Bechamp reaction
M. A. Bechamp (1863). "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique ...
Zaleplon
The anilide nitrogen is then alkylated by means of sodium hydride and ethyl iodide to give 3. The first step in the ...
Alphamethylthiofentanyl
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AA560
It is an anilide derivative and analogue of the NSAA flutamide, and shows greater in vivo antiandrogenic potency than does ... Anilides, Nonsteroidal antiandrogens, Organochlorides, All stub articles, Genito-urinary system drug stubs). ...
Ropivacaine
Anilides). ...
3-Hydroxy-2-naphthoic acid
... is a precursor to many anilides, such as Naphthol AS, which are reactive toward diazonium salts to ...
Acetanilide
ISBN 978-0-85404-182-4. N-Phenyl derivatives of primary amides are called 'anilides' and may be named using the term 'anilide' ...
List of fentanyl analogues
Articles with short description, Short description is different from Wikidata, Fentanyl, Anilides, Chemistry-related lists, ...
Nikolai Menshutkin
Subsequently, the rate of chemical change was studied in the case of the formation of amides and anilides by the action of ...
Crotonylfentanyl
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The dependence on pH of the molluscicidal activity of the ethanolamine salt of 5,2 -dichloro- 4' -nitrosalicylic anilide in...
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Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides | The Buchwald Research Group
Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides G. Brasche, García-Fortanet, J. , and Buchwald ... The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. ... S. L. "Twofold C−H Functionalization: Palladium-Catalyzed Ortho Arylation of Anilides", Org. Lett., 2008, 10(11), 2207-2210. ...
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Efficient Synthesis of Optically Active Atropisomeric Anilides through Catalytic Asymmetric N-Arylation Reaction. In: J. Am. ... Kitagawa O, Takahashi M, Yoshikawa M, Taguchi T. Efficient Synthesis of Optically Active Atropisomeric Anilides through ... Kitagawa, O, Takahashi, M, Yoshikawa, M & Taguchi, T 2005, Efficient Synthesis of Optically Active Atropisomeric Anilides ... Efficient Synthesis of Optically Active Atropisomeric Anilides through Catalytic Asymmetric N-Arylation Reaction. / Kitagawa, ...
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The methods of synthesis and pharmacologicaly properties of 4-bromo- and 4,6-dibromo-2-carboxysuccinalic acids anilides * N.P. ... Synthesis of 4-bromo- and 4,6-dibromo-2-carboxysuccinalic acids anilides has been carried out and their physico-chemical ... physico-chemical and pharmacological properties of anilides of 3,5-dibrom-N-phenylanthranylic acids , Farmatsevtychnyi zhurnal ... 6-dibromo-2-carboxysuccinalic acids anilides. Farmatsevtychnyi Zhurnal, (2), 49-55. Retrieved from https://pharmj.org.ua/index. ...
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Anilides. Direct Parent. Aromatic anilides. Alternative Parents. Pyrazolylpyridines / Nicotinamides / Dialkylarylamines / ... 3-pyrazolylpyridine / Alcohol / Alkyl chloride / Alkyl fluoride / Alkyl halide / Amine / Aminopyridine / Aromatic anilide / ... This compound belongs to the class of organic compounds known as aromatic anilides. These are aromatic compounds containing an ... anilide group in which the carboxamide group is substituted with an aromatic group. They have the general structure RNC(=O)R, ...
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naphthol dye; azoic dye; Naphthol Red; Permanent Carmine; Grela Red; napthol dye (sp); hydroxynaphthoic anilide; Naphtol Anilid ... naphthol dye; azoic dye; Naphthol Red; Permanent Carmine; Grela Red; napthol dye (sp); hydroxynaphthoic anilide; Naphtol Anilid ... naphthol dye; azoic dye; Naphthol Red; Permanent Carmine; Grela Red; napthol dye (sp); hydroxynaphthoic anilide; Naphtol Anilid ...
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in all the anilides except in the. p. -nitro anilide in which the. s-trans. form was predominant. The relative stabilities of ... All the anilides studied were found to exist as equilibrium mixtures of. s-cis. and. s-trans. forms in benzene. ... the conformers were found to depend upon the electrostatic repulsions between the anilide nitrogen and the β-carbon atom in the ...
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- psycholeptics : Belongs to the class of anilide preparations. (mims.com)
Chemicals1
- Manufacturers of chemicals like 4 amino acetanilide, 3 amino acetanilide, 3 propionamido anilide, 2.5 di chloro para phenylene diamine. (eindiabusiness.com)
Group2
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- Optically active enantiomers of the formula I STR1 where R is a group of the formulae STR2 R1 and R2, among others, are halogen or CF3 and Z is a carboxyl, carboxylate, carboxylic acid ester, thioester, carbonamide, carboxylic acid anilide, carbohydrazide or thioamide group, are interesting herbicides the effect of which is considerably superior to that of the optically inactive racemates. (lookchem.com)
Form3
- The ortho arylation of anilides to form biphenyls via a twofold C-H functionalization/C-C bond-forming process is described. (mit.edu)
- The s-cis form was predominant over the s-trans in all the anilides except in the p -nitro anilide in which the s-trans form was predominant. (ias.ac.in)
- The relative stabilities of the conformers were found to depend upon the electrostatic repulsions between the anilide nitrogen and the β-carbon atom in the s-trans form and those between the π-electrons of the C=O and C=C bonds in the s-cis form. (ias.ac.in)
Found2
Derivatives3
- The data about the inhibition of hK1 by 4-aminobenzamidine and benzamidine help to explain previous observations that esters, anilides or chloromethyl ketone derivatives of Na-substituted arginine are more sensitive substrates or inhibitors of hK1 than the corresponding lysine compounds. (archive.org)
- Tytuł oryginału: Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT 1A /5-HT 7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. (edu.pl)
- Salicylic acid and derivatives , Anilides . (rxwiki.com)
Inhibitors3
- 10. Sulfonamide anilides, a novel class of histone deacetylase inhibitors, are antiproliferative against human tumors. (nih.gov)
- ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS - Compounds useful as Rho kinase inhibitors of formula (I): wherein variable are as defined herein are provided. (patentsencyclopedia.com)
- RQ-00203078 As anticipated, only compounds with metal chelating elements such as hydroxamates and ortho-hydroxy anilides proved to be effective inhibitors of these enzymes. (exemestane.info)
SAHA4
- in primary endometriotic stromal cells using three different classes of HDACIs (VPA, suberoyl anilide bishydroxamine or SAHA and apicidin. (medscape.com)
- Verwendete HDI waren suberoyl anilide hydroxamic acid (SAHA), Natriumbutyrat (NaB) und das Benzamid MS-275. (uni-greifswald.de)
- We used three different HDI: suberoyl anilide hydroxamic acid (SAHA), sodiumbutyrate (NaB) and the benzamide MS-275. (uni-greifswald.de)
- Suberoyl Anilide Hydroxamic Acid (SAHA) or Vorinostat is a drug which commercially available to treat the cancer, but still has some side effects. (ui.ac.id)
Esters1
- For several substances (isothiazolones, anilides, diamidines, inorganic acids and their esters, alcohols), little information is available on resistance or tolerance [ 7 ]. (springeropen.com)
Compounds1
- belongs to the class of organic compounds known as anilides. (t3db.ca)
Medications1
- Cephadyn is a brand name medication included in a group of medications called Anilides . (rxwiki.com)
Belongs1
- Belongs to the class of anilide preparations. (mims.com)
Product1
- The reaction of methyl iodide with an anilide anion prepared from 2,4,6-tri-tert-butylanilide and NaH in CH 3 CN gave N-methyl anilide (N-alkylation product) as a major product, while in the reaction of benzyl bromide with the anilide anion in DMF, O-benzyl imidate (O-alkylation product) was obtained with almost complete selectivity. (elsevier.com)