Anilides are organic compounds resulting from the reaction of aniline (a primary aromatic amine) with carboxylic acids or their derivatives, forming amides, which have various applications in pharmaceuticals and agrochemicals.
Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.
Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.

Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways. (1/748)

Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer. To determine the molecular mechanism(s) of androgen-independent regulation of the PSA gene, the possibility that the androgen receptor (AR) is activated in the absence of androgen by stimulation of protein kinase A (PKA) was investigated. Activation of PKA by forskolin resulted in elevated expression of the PSA gene in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen, bicalutamide. Further evidence that induction of PSA gene expression was dependent on AR was obtained from experiments using PC3 cells devoid of AR. Neither PSA, PB, nor ARR3 androgen-responsive reporters could be induced by activation of PKA in the absence of transfected AR. In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Lastly, cotransfection of an expression vector for a chimeric protein encoding the amino-terminal domain of the human AR linked to Gal4 and a 5xGal4UAS reporter gene construct resulted in activation of the amino-terminal domain of the AR by stimulation of PKA activity. These results demonstrate androgen-independent induction of PSA gene expression in prostate cancer cells by an AR-dependent pathway.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (2/748)

We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver.  (+info)

Metabolism of aminoacyl-p-nitroanilides by rat mammary tissue. (3/748)

We have examined the metabolism of aminoacyl-p-nitroanilides by rat mammary tissue isolated from rats during late pregnancy, peak lactation and late lactation. The rate of hydrolysis depended upon the chemical nature of the aminoacyl-p-nitroanilide compound and the physiological state of the donor animals. Thus, mammary tissue isolated from rats during late pregnancy and peak lactation hydrolysed aminoacyl-p-nitroanilides in the order L-met-p-nitroanilide=L-leu-p-nitroanilide>L-lys-p-nitroanilide>gamma- glu-p-nitroanilide. The order of activity was the same for mammary tissue taken from rats during late lactation except that L-lys-p-nitroanilide was hydrolysed at the same rate as the neutral aminoacyl-p-nitroanilides. Mammary tissue from peak lactating rats also hydrolysed alpha-L-glu-p-nitroanilide and alpha-L-asp-p-nitroanilide but to a lesser extent than the other compounds tested. The anionic aminoacyl-p-nitroanilides were able to trans-stimulate D-aspartate efflux from mammary tissue explants and the perfused mammary gland via the high-affinity anionic amino acid carrier. The clearance of gly-L-phe by the perfused mammary gland was markedly inhibited by L-phe. The results suggest that mammary tissue expresses a variety of dipeptidases at the basolateral aspect of the mammary epithelium which are capable of hydrolysing peptides extracellularly. These enzymes may be important for providing amino acids for milk protein synthesis and/or inactivating signal peptides.  (+info)

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. (4/748)

The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR transcripts and genes from a large series of bone marrow metastases. Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by flutamide. In contrast, the single mutant AR found among 17 patients treated with androgen ablation monotherapy was not flutamide stimulated. Patients with flutamide-stimulated AR mutations responded to subsequent treatment with bicalutamide, an AR antagonist that blocks the mutant ARs. These findings demonstrate that AR mutations occur in response to strong selective pressure from flutamide treatment.  (+info)

Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. (5/748)

Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the development of therapy-resistant tumours, we established a new tumour model which closely resembles the situation in patients who receive androgen ablation therapy. Androgen-sensitive LNCaP cells were kept in androgen-depleted medium for 87 passages. The new LNCaP cell subline established in this manner, LNCaP-abl, displayed a hypersensitive biphasic proliferative response to androgen until passage 75. Maximal proliferation of LNCaP-abl cells was achieved at 0.001 nM of the synthetic androgen methyltrienolone (R1881), whereas 0.01 nM of this compound induced the same effect in parental cells. At later passages (> 75), androgen exerted an inhibitory effect on growth of LNCaP-abl cells. The non-steroidal anti-androgen bicalutamide stimulated proliferation of LNCaP-abl cells. AR protein expression in LNCaP-abl cells increased approximately fourfold. The basal AR transcriptional activity was 30-fold higher in LNCaP-abl than in LNCaP cells. R1881 stimulated reporter gene activity in LNCaP-abl cells even at 0.01 nM, whereas 0.1 nM of R1881 was needed for induction of the same level of reporter gene activity in LNCaP cells. Bicalutamide that acts as a pure antagonist in parental LNCaP cells showed agonistic effects on AR transactivation activity in LNCaP-abl cells and was not able to block the effects of androgen in these cells. The non-steroidal AR blocker hydroxyflutamide exerted stimulatory effects on AR activity in both LNCaP and LNCaP-abl cells; however, the induction of reporter gene activity by hydroxyflutamide was 2.4- to 4-fold higher in the LNCaP-abl subline. The changes in AR activity were associated neither with a new alteration in AR cDNA sequence nor with amplification of the AR gene. Growth of LNCaP-abl xenografts in nude mice was stimulated by bicalutamide and repressed by testosterone. In conclusion, our results show for the first time that the nonsteroidal anti-androgen bicalutamide acquires agonistic properties during long-term androgen ablation. These findings may have repercussions on the natural course of prostate cancer with androgen deprivation and on strategies of therapeutic intervention.  (+info)

Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat. (6/748)

The urinary metabolites of 3-methyl-4-trifluoromethylaniline in the rat were characterized and quantified using a combination of (19)F NMR, HPLC-NMR ((1)H and (19)F), and HPLC-mass spectrometry techniques. The major routes of metabolism were amine N-acetylation and methyl group C-oxidation to the benzyl alcohol (with subsequent glucuronide conjugation) and further to the corresponding benzoic acid derivative. Quantitatively only a small proportion of the urinary metabolites contained the free amino group, and these were products of ortho-hydroxylation (2 and 6 position) with additional conjugation to form the ether sulfates and glucuronides. An N-glucuronide of the parent compound was also identified. 3-Methyl-4-trifluoromethylacetanilide ((13)C-labeled in the acetyl group) gave virtually the same overall metabolite profile as 3-methyl-4-trifluoromethylaniline; however, a significant level of futile N-deacetylation and reacetylation occurred as ca. 50% of the excreted N-acetylated major metabolites contained no (13)C-label at the acetyl, having been replaced by an endogenous (12)C-acetyl source. This level of futile deacetylation is the highest yet reported for a substituted aniline/acetanilide and indicates a high degree of electronic activation of the amino group toward the acetyltransferase enzymes in vivo.  (+info)

Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: results of an Italian Prostate Cancer Project study. (7/748)

PURPOSE: To compare the efficacy of bicalutamide monotherapy to maximal androgen blockade (MAB) in the treatment of advanced prostatic cancer. PATIENTS AND METHODS: Previously untreated patients with histologically proven stage C or D disease (American Urological Association Staging System) were randomly allocated to receive either bicalutamide or MAB. After disease progression, patients treated with bicalutamide were assigned to castration. The primary end point for this trial was overall survival. Secondary end points included response to treatment, disease progression, treatment safety, quality-of-life (QOL), and sexual function. RESULTS: A total of 108 patients received bicalutamide and 112 received MAB. There was no difference in the percentage of patients whose prostate-specific antigen returned to normal levels. At the time of the present analysis (median follow-up time, 38 months; range, 1 to 60 months), 129 patients progressed and 89 died. There was no difference in the duration of either progression-free survival or overall survival. However, a survival trend favored bicalutamide in stage C disease but MAB in stage D disease. Overall and subgroup trends were confirmed by multivariate analysis. Serious adverse events and treatment discontinuations were more common in patients receiving MAB (P =.08 and P =.04, respectively). Fewer patients in the bicalutamide group complained of loss of libido (P =. 01) and of erectile dysfunction (P =.002). Significant trends favored bicalutamide-treated patients also with respect to their QOL, namely relative to social functioning, vitality, emotional well-being, and physical capacity. CONCLUSION: Bicalutamide monotherapy yielded comparable results relative to standard treatment with MAB, induced fewer side effects, and produced a better QOL.  (+info)

Stimulation of bradykinin B(1) receptors induces vasodilation in conductance and resistance coronary vessels in conscious dogs: comparison with B(2) receptor stimulation. (8/748)

BACKGROUND: Constitutive bradykinin B(1) receptors have been identified in dogs; however, their physiological implications involving the coronary circulation remain to be determined. This study examined, in conscious dogs, the coronary response to des-Arg(9)-bradykinin (a B(1) receptor agonist) and the mechanisms involved. METHODS AND RESULTS: Eleven dogs were instrumented with a left ventricular micromanometer, a circumflex coronary catheter, a cuff occluder, a Doppler flow probe, and ultrasonic crystals to measure coronary blood flow velocity (CBFv) and coronary diameter (CD). Intracoronary des-Arg(9)-bradykinin (3 to 100 ng/kg) and bradykinin (0.1 to 10 ng/kg) did not modify systemic hemodynamics but dose-dependently increased CBFv and CD. Des-Arg(9)-bradykinin was less potent than bradykinin. Hoe 140 (a B(2) antagonist, 10 microg/kg) abolished the effects of bradykinin but did not influence the effects of des-Arg(9)-bradykinin. When CBFv increase was prevented by the cuff occluder, CD responses to bradykinin and des-Arg(9)-bradykinin were maintained. Intracoronary lisinopril (0. 75 mg) increased the CD response to bradykinin, with only minimal effect on CBFv, and extended the duration of the effect. Lisinopril did not alter des-Arg(9)-bradykinin responses. Intracoronary N(omega)-nitro-L-arginine (2 mg/kg) decreased the CD effect of bradykinin and prevented the CBFv and CD effects of des-Arg(9)-bradykinin. The relaxing effect of des-Arg(9)-bradykinin on isolated coronary rings was prevented by des-Arg(9), [Leu(8)]-bradykinin. CONCLUSIONS: In the conscious dog, B(1) receptors are present in coronary vessels, and their stimulation produces vasodilation in conductance and resistance vessels, which is mediated essentially by NO but not modulated by angiotensin-converting enzyme. However, the coronary vasodilation induced by B(1) receptor stimulation is not as great as that produced by B(2) receptor stimulation.  (+info)

Anilides are chemical compounds that result from the reaction between aniline (a organic compound with the formula C6H5NH2) and a carboxylic acid or its derivative. The resulting compound has the general structure R-CO-NH-C6H5, where R represents the rest of the carboxylic acid molecule.

Anilides are widely used in the pharmaceutical industry to produce various drugs, such as analgesics, anti-inflammatory agents, and antifungal agents. Some examples of anilide-based drugs include acetaminophen (also known as paracetamol), fenacetin, and flufenamic acid.

It's worth noting that some anilides have been found to have toxic effects on the liver and kidneys, so they must be used with caution and under medical supervision.

Allylamine is an organic compound with the formula CH2=CH-CH2-NH2. It is a colorless liquid that is soluble in water and polar organic solvents. Allylamine is used as a building block in the synthesis of various chemical compounds, including pharmaceuticals, agrochemicals, and polymers.

In the medical field, allylamine derivatives are used as antifungal agents. These drugs work by inhibiting the enzyme squalene epoxidase, which is necessary for the synthesis of ergosterol, a key component of fungal cell membranes. By blocking the production of ergosterol, allylamine derivatives disrupt the integrity of fungal cell membranes and prevent the growth of fungi. Examples of allylamine antifungal drugs include terbinafine and naftifine.

Aminopropionitrile is a chemical compound with the formula NPN(H2)CH2CH2CN. It is an irritant that can cause damage to the eyes, skin, and respiratory system. It is used in the manufacture of certain plastics and resins, and has also been studied for its potential effects on the human body. Some research suggests that aminopropionitrile may interfere with the normal functioning of collagen, a protein that helps to provide structure and support to tissues and organs in the body. This has led to interest in the use of aminopropionitrile as a potential treatment for certain conditions related to collagen, such as scleroderma. However, more research is needed to determine the safety and effectiveness of this use.

In organic chemistry, anilides (or phenylamides) are a class of organic compounds with the general structure R−C(=O)−N(−R')− ... Media related to Anilides at Wikimedia Commons v t e (Articles with short description, Short description is different from ... 1, p. 82 "Anilide herbicides". Pesticide Target Interaction Database. East China University of Science & Technology. Archived ... Aniline reacts with acyl chlorides or carboxylic anhydrides to give anilides. For example, reaction of aniline with acetyl ...
1. Primary alpha-amino anilides". Journal of Medicinal Chemistry. 22 (10): 1171-6. doi:10.1021/jm00196a005. PMID 513064. Burton ... Anilides, All stub articles, Cardiovascular system drug stubs). ...
DE 2130450, Neri RO, Topliss JG, "Substituierte Anilide [Substituted anilides]", published 1972-12-21, assigned to Sherico Ltd ... Unlike the hormones with which it competes, flutamide is not a steroid; rather, it is a substituted anilide. Hence, it is ... Anilides, Anti-acne preparations, Aryl hydrocarbon receptor agonists, CYP17A1 inhibitors, Enantiopure drugs, Hair loss ...
None of the in vivo or in vitro studies performed with toxic-oil-specific components, such as fatty acid anilides, and esters ... Similar results were obtained after administration of fatty acid anilides. Data discrepancies combined with both a high level ...
Analgesic potency and acute toxicity of substituted anilides and benzamides. Toxicology and Applied Pharmacology 1971;19(1):20- ...
Screening studies on FDCA-derived anilides showed their important anti-bacterial action. The diacid itself is a strong ...
The amides formed from aniline are sometimes called anilides, for example CH3−C(=O)−NH−C6H5 is acetanilide. At high ... temperatures aniline and carboxylic acids react to give the anilides. N-Methylation of aniline with methanol at elevated ...
It is a bicyclic compound (has two rings) and can be classified as and has variously been referred to as an anilide (N- ... First-generation NSAAs including bicalutamide, flutamide, and nilutamide are all synthetic, nonsteroidal anilide derivatives ... C]linically relevant antiandrogens currently are nonsteroidal anilide derivatives. Antiandrogens used for prostate cancer ... Anilides, Anti-acne preparations, Antiprogestogens, AstraZeneca brands, Benzonitriles, Benzosulfones, Bicalutamide, CYP3A4 ...
It is the anilide of 3-hydroxy-2-carboxynaphthalene. Many analogous compounds are known, designated with a differing suffix. ...
Primary amines, aromatic amines, or lithium anilides can also be used as nucleophiles. Protective O-methylation often follows ...
"Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O". The Journal of Organic ...
It is classified as both a salicylamide and an anilide. Derivatives of salicylanilide have a variety of pharmacological uses. ...
US3016382A N-substituted anilides and method of preparing the same Portoghese PS (March 1965). "Stereochemical Studies on ... Anilides, Mu-opioid receptor agonists, All stub articles, Analgesic stubs). ...
"Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5". Bioorganic & Medicinal ...
A Neat Access to Anilides". ChemistrySelect. 2 (5): 1770-1773. doi:10.1002/slct.201601965. Davis, Garrett J.; Sofka, Holly A.; ...
... share an anilide ring structure. The structures can be seen in figure 7, where the anilide ring is coloured red. These three ... Replacing the anilide with an alkene gives weakly active compounds, which can be attributed to the lack of intramolecular ...
The effect of PMDTA on lithium anilide is illustrative of PMDTA's complexing power. The complex, [{PhN(H)Li}3·2PMDTA], is ... ISBN 978-3-527-29390-2. Barr, D.; Clegg, W.; Cowton, L.; Horsburgh, L.; Mackenzie, F. M.; Mulvey, R. (1995). "Lithium Anilide ...
In 2009, Gaunt's group reported a copper catalyzed meta-selective C-H arylation reaction on anilide derivatives. Despite the ... It is compatible with a spectrum of substituted anilide as well as different bisaryliodonium salts. However, the meta- ... selectivity is lost when highly ortho/para-directing methoxy group substitutes one of the meta-hydrogen of the anilide, which ... the arylation occurs exclusively on the meta position on a variety of anilide substrates. Remarkably, the regioselectivity is ...
... as arsenic acid anilide. Also biologist, physician, and pharmacist, Béchamp reported it 40 to 50 times less toxic as a drug ... "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique". Compt. Rend. 56: ...
M. A. Bechamp (1863). "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique ...
The anilide nitrogen is then alkylated by means of sodium hydride and ethyl iodide to give 3. The first step in the ...
US patent 5589493, Eicken, K; Goetz, N & Harreus, A et al., "Anilide derivatives and their use for combating botrytis", ...
The compound is an anilide which combines a heterocyclic acid with aniline to give an inhibitor of succinate dehydrogenase ( ... Anilides, Sulfones, Fungicides, Heterocyclic compounds with 1 ring). ...
The compound is an anilide which combines a heterocyclic acid with aniline to give an inhibitor of succinate dehydrogenase ( ...
It is an anilide derivative and analogue of the NSAA flutamide, and shows greater in vivo antiandrogenic potency than does ... Anilides, Nonsteroidal antiandrogens, Organochlorides, Abandoned drugs, All stub articles, Genito-urinary system drug stubs). ...
... is a precursor to many anilides, such as Naphthol AS, which are reactive toward diazonium salts to ...
ISBN 978-0-85404-182-4. N-Phenyl derivatives of primary amides are called 'anilides' and may be named using the term 'anilide' ...
Articles with short description, Short description is different from Wikidata, Fentanyl, Anilides, Chemistry-related lists, ...
Subsequently, the rate of chemical change was studied in the case of the formation of amides and anilides by the action of ...
Anilides, Designer drugs, Mu-opioid receptor agonists, Piperidines, Synthetic opioids, Carbamates). ...
In organic chemistry, anilides (or phenylamides) are a class of organic compounds with the general structure R−C(=O)−N(−R)− ... Media related to Anilides at Wikimedia Commons v t e (Articles with short description, Short description is different from ... 1, p. 82 "Anilide herbicides". Pesticide Target Interaction Database. East China University of Science & Technology. Archived ... Aniline reacts with acyl chlorides or carboxylic anhydrides to give anilides. For example, reaction of aniline with acetyl ...
Citation: anilides in IUPAC Compendium of Chemical Terminology, 3rd ed. International Union of Pure and Applied Chemistry; ...
Geone is a brand name medication included in a group of medications called Anilides. For more information about Geone see its ...
Theraflu Daytime Severe Cold & Cough - Get up-to-date information on Theraflu Daytime Severe Cold & Cough side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Theraflu Daytime Severe Cold & Cough
Kitagawa O, Izawa H, Taguchi T, Shiro M. An Efficient Synthesis of Optically Active Axially Chiral Anilide and Its Application ... Kitagawa, O, Izawa, H, Taguchi, T & Shiro, M 1997, An Efficient Synthesis of Optically Active Axially Chiral Anilide and Its ... Kitagawa, O., Izawa, H., Taguchi, T., & Shiro, M. (1997). An Efficient Synthesis of Optically Active Axially Chiral Anilide and ... T1 - An Efficient Synthesis of Optically Active Axially Chiral Anilide and Its Application to Iodine-mediated Asymmetric Diels- ...
Other names: Acetoacetamidobenzene; Acetoacetanilide; Acetoacetic acid anilide; Acetoacetic anilide; [(Acetoacetyl)amino] ...
Paracetamol: other analgesics and antipyretics, anilides.. Pharmacotherapeutic Group: Analgesics and Antipyretics, Anilides ...
Anilide fungicide; Acylamino acid fungicide. Minimum active substance purity. 950 g kg⁻¹. ...
Anilides. N02BE71. Paracetamol, combinations with psycholeptics. Shelf life: 60. Route of admin.: Oral use ...
Further studies of metyrapone effects upon anilide hydroxylation. Authors. Leibman KC; Ortiz E ...
psycholeptics : Belongs to the class of anilide preparations. Used to relieve pain and fever. ... psycholeptics : Belongs to the class of anilide preparations. Used to relieve pain and fever. ... psycholeptics : Belongs to the class of anilide preparations. Used to relieve pain and fever. ...
Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Nicholls, I.A. (2010). Mechanism of Phenylalanine Anilide Molecularly ... Resolving Debate on the Nature of Template Recognition in Phenylalanine Anilide Imprinted Polymers. Journal of Molecular ... The nature and extent of interactions in phenylalanine anilide molecularly imprinted polymer prepolymerisation mixtures: a new ... The Nature and Extent of Template-Template Complexation in Phenylalanine Anilide Molecularly Imprinted Polymers. . ...
amidines, anilides, anilinopyrimidines, aromatic hydrocarbons,. chlorophenyls, arylaminopropionic acids, aryloxyalkanoic acids, ... acylalanines, alkanamides, amidines, anilides, anilinopyrimidines, aromatic hydrocarbons, chlorophenyls, arylaminopropionic ... acylalanines, alkanamides, amidines, anilides, anilinopyrimidines, aromatic hydrocarbons, chlorophenyls, arylaminopropionic ...
Substituted anilides from chitin-based 3-acetamido-furfural. Research output: Contribution to journal › Article › Academic › ...
Gericet is a brand name medication included in a group of medications called Anilides. For more information about Gericet see ...
Goodys Headache Relief Shot is a brand name medication included in a group of medications called Anilides. For more ...
Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in ... N2 - Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy ... AB - Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy ... abstract = "Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial ...
103) Synthesis of Anilides by Aminolysis of Unactivated Esters using MnCl2 in Combination with strong Bases as Catalyst. Adv. ...
Formation of fatty acid anilide compounds increased with storage time. Deodorization led to a reduction of total anilides in ... Fatty acid anilides, Rapeseed oil, 3-phenylamino-1, 2-propanediol, Toxic oil syndrome Abstract. In 1981, toxic oil syndrome, a ... Since fatty acid anilide concentrations in these oils are associated with risk of disease, w e studied the formation of aniline ...
Anilides and quinolones with nitrogen-bearing substituents from benzothiophene- and thienothiophene- series: synthesis, ...
Suberoyl anilide hydroxamic acid (SAHA, a pan-HDAC inhibitor) and 3-Deazaneplanocin A (DZNep, a polycomb EZH2 subunit inhibitor ...
Anilides; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Carcinoma, Basal Cell; Drug Resistance, Neoplasm ...
herbicides (anilide). Notes:. Structure:. Pronunciation:. sī-prō-mǐd Guide to British pronunciation. ...
H-GLU(ANILIDE)-OH; N5-phenyl-L-glutamine; H-Gln(Ph)-OH; L-GLUTAMIC ACID-Y-ANILIDE; (S)-2-AMINO-5-ANILIDE-5-OXOPENTANOIC ACID; ...
... and an oxalic anilide compound. ...
Lidocaine/Anilide derivatives: Lignocaine, Mepivacaine, Prilocaine, Etidocaine.. Miscellaneous: Phenacaine, Diperodon, ...
  • At high temperatures, aniline and carboxylic acids react to give anilides. (wikipedia.org)
  • A variety systemic lupus erythematosus of carboxylic acids and for anilide derivatives. (faurerom.com)
  • Sixteen new anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in Plasmodium berghei infected mice. (johnshopkins.edu)
  • An Efficient Synthesis of Optically Active Axially Chiral Anilide and Its Application to Iodine-mediated Asymmetric Diels-Alder Reaction. (elsevierpure.com)
  • psycholeptics : Belongs to the class of anilide preparations. (mims.com)
  • In organic chemistry, anilides (or phenylamides) are a class of organic compounds with the general structure R−C(=O)−N(−R')−C6H5. (wikipedia.org)
  • Formation of fatty acid anilide compounds increased with storage time. (csic.es)
  • Aniline reacts with acyl chlorides or carboxylic anhydrides to give anilides. (wikipedia.org)
  • Deodorization led to a reduction of total anilides in all the samples, particularly at temperatures above 245ºC. (csic.es)
  • 9. Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56(lck) inhibitors. (nih.gov)
  • Belongs to the class of anilide preparations. (mims.com)