AnilidesAllylamine: Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.Societies, Pharmaceutical: Societies whose membership is limited to pharmacists.Education, Pharmacy, Graduate: Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.Analgesics: Compounds capable of relieving pain without the loss of CONSCIOUSNESS.Drug Industry: That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Technology, Pharmaceutical: The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.Hydrocodone: Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.Nonprescription Drugs: Medicines that can be sold legally without a DRUG PRESCRIPTION.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Drug Labeling: Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Analgesics, Non-Narcotic: A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.Sutures: Materials used in closing a surgical or traumatic wound. (From Dorland, 28th ed)Containment of Biohazards: Provision of physical and biological barriers to the dissemination of potentially hazardous biologically active agents (bacteria, viruses, recombinant DNA, etc.). Physical containment involves the use of special equipment, facilities, and procedures to prevent the escape of the agent. Biological containment includes use of immune personnel and the selection of agents and hosts that will minimize the risk should the agent escape the containment facility.Cranial Sutures: A type of fibrous joint between bones of the head.Suture Techniques: Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).PrintingInsulator Elements: Nucleic acid regulatory sequences that limit or oppose the action of ENHANCER ELEMENTS and define the boundary between differentially regulated gene loci.InkWhiplash Injuries: Hyperextension injury to the neck, often the result of being struck from behind by a fast-moving vehicle, in an automobile accident. (From Segen, The Dictionary of Modern Medicine, 1992)Printers' MarksElectrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.AmidohydrolasesEstersKeratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Retinoids: A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.Dictionaries, ChemicalAgrochemicals: Chemicals used in agriculture. These include pesticides, fumigants, fertilizers, plant hormones, steroids, antibiotics, mycotoxins, etc.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Biopharmaceutics: The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Biological Ontologies: Structured vocabularies describing concepts from the fields of biology and relationships between concepts.Equipment Design: Methods of creating machines and devices.Magnetite Nanoparticles: Synthesized magnetic particles under 100 nanometers possessing many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The particles are usually coated with a variety of polymeric compounds.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Magnetics: The study of MAGNETIC PHENOMENA.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Pesticides: Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.Fumigation: The application of smoke, vapor, or gas for the purpose of disinfecting or destroying pests or microorganisms.Sulfinic Acids: Any of the monobasic inorganic or organic acids of sulfur with the general formula RSO(OH). (From McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Fluorides: Inorganic salts of hydrofluoric acid, HF, in which the fluorine atom is in the -1 oxidation state. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Sodium and stannous salts are commonly used in dentifrices.Pesticide Residues: Pesticides or their breakdown products remaining in the environment following their normal use or accidental contamination.Sodium Fluoride: A source of inorganic fluoride which is used topically to prevent dental caries.Phosphoadenosine Phosphosulfate: 3'-Phosphoadenosine-5'-phosphosulfate. Key intermediate in the formation by living cells of sulfate esters of phenols, alcohols, steroids, sulfated polysaccharides, and simple esters, such as choline sulfate. It is formed from sulfate ion and ATP in a two-step process. This compound also is an important step in the process of sulfur fixation in plants and microorganisms.

Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways. (1/748)

Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer. To determine the molecular mechanism(s) of androgen-independent regulation of the PSA gene, the possibility that the androgen receptor (AR) is activated in the absence of androgen by stimulation of protein kinase A (PKA) was investigated. Activation of PKA by forskolin resulted in elevated expression of the PSA gene in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen, bicalutamide. Further evidence that induction of PSA gene expression was dependent on AR was obtained from experiments using PC3 cells devoid of AR. Neither PSA, PB, nor ARR3 androgen-responsive reporters could be induced by activation of PKA in the absence of transfected AR. In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Lastly, cotransfection of an expression vector for a chimeric protein encoding the amino-terminal domain of the human AR linked to Gal4 and a 5xGal4UAS reporter gene construct resulted in activation of the amino-terminal domain of the AR by stimulation of PKA activity. These results demonstrate androgen-independent induction of PSA gene expression in prostate cancer cells by an AR-dependent pathway.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (2/748)

We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver.  (+info)

Metabolism of aminoacyl-p-nitroanilides by rat mammary tissue. (3/748)

We have examined the metabolism of aminoacyl-p-nitroanilides by rat mammary tissue isolated from rats during late pregnancy, peak lactation and late lactation. The rate of hydrolysis depended upon the chemical nature of the aminoacyl-p-nitroanilide compound and the physiological state of the donor animals. Thus, mammary tissue isolated from rats during late pregnancy and peak lactation hydrolysed aminoacyl-p-nitroanilides in the order L-met-p-nitroanilide=L-leu-p-nitroanilide>L-lys-p-nitroanilide>gamma- glu-p-nitroanilide. The order of activity was the same for mammary tissue taken from rats during late lactation except that L-lys-p-nitroanilide was hydrolysed at the same rate as the neutral aminoacyl-p-nitroanilides. Mammary tissue from peak lactating rats also hydrolysed alpha-L-glu-p-nitroanilide and alpha-L-asp-p-nitroanilide but to a lesser extent than the other compounds tested. The anionic aminoacyl-p-nitroanilides were able to trans-stimulate D-aspartate efflux from mammary tissue explants and the perfused mammary gland via the high-affinity anionic amino acid carrier. The clearance of gly-L-phe by the perfused mammary gland was markedly inhibited by L-phe. The results suggest that mammary tissue expresses a variety of dipeptidases at the basolateral aspect of the mammary epithelium which are capable of hydrolysing peptides extracellularly. These enzymes may be important for providing amino acids for milk protein synthesis and/or inactivating signal peptides.  (+info)

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. (4/748)

The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR transcripts and genes from a large series of bone marrow metastases. Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by flutamide. In contrast, the single mutant AR found among 17 patients treated with androgen ablation monotherapy was not flutamide stimulated. Patients with flutamide-stimulated AR mutations responded to subsequent treatment with bicalutamide, an AR antagonist that blocks the mutant ARs. These findings demonstrate that AR mutations occur in response to strong selective pressure from flutamide treatment.  (+info)

Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. (5/748)

Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the development of therapy-resistant tumours, we established a new tumour model which closely resembles the situation in patients who receive androgen ablation therapy. Androgen-sensitive LNCaP cells were kept in androgen-depleted medium for 87 passages. The new LNCaP cell subline established in this manner, LNCaP-abl, displayed a hypersensitive biphasic proliferative response to androgen until passage 75. Maximal proliferation of LNCaP-abl cells was achieved at 0.001 nM of the synthetic androgen methyltrienolone (R1881), whereas 0.01 nM of this compound induced the same effect in parental cells. At later passages (> 75), androgen exerted an inhibitory effect on growth of LNCaP-abl cells. The non-steroidal anti-androgen bicalutamide stimulated proliferation of LNCaP-abl cells. AR protein expression in LNCaP-abl cells increased approximately fourfold. The basal AR transcriptional activity was 30-fold higher in LNCaP-abl than in LNCaP cells. R1881 stimulated reporter gene activity in LNCaP-abl cells even at 0.01 nM, whereas 0.1 nM of R1881 was needed for induction of the same level of reporter gene activity in LNCaP cells. Bicalutamide that acts as a pure antagonist in parental LNCaP cells showed agonistic effects on AR transactivation activity in LNCaP-abl cells and was not able to block the effects of androgen in these cells. The non-steroidal AR blocker hydroxyflutamide exerted stimulatory effects on AR activity in both LNCaP and LNCaP-abl cells; however, the induction of reporter gene activity by hydroxyflutamide was 2.4- to 4-fold higher in the LNCaP-abl subline. The changes in AR activity were associated neither with a new alteration in AR cDNA sequence nor with amplification of the AR gene. Growth of LNCaP-abl xenografts in nude mice was stimulated by bicalutamide and repressed by testosterone. In conclusion, our results show for the first time that the nonsteroidal anti-androgen bicalutamide acquires agonistic properties during long-term androgen ablation. These findings may have repercussions on the natural course of prostate cancer with androgen deprivation and on strategies of therapeutic intervention.  (+info)

Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat. (6/748)

The urinary metabolites of 3-methyl-4-trifluoromethylaniline in the rat were characterized and quantified using a combination of (19)F NMR, HPLC-NMR ((1)H and (19)F), and HPLC-mass spectrometry techniques. The major routes of metabolism were amine N-acetylation and methyl group C-oxidation to the benzyl alcohol (with subsequent glucuronide conjugation) and further to the corresponding benzoic acid derivative. Quantitatively only a small proportion of the urinary metabolites contained the free amino group, and these were products of ortho-hydroxylation (2 and 6 position) with additional conjugation to form the ether sulfates and glucuronides. An N-glucuronide of the parent compound was also identified. 3-Methyl-4-trifluoromethylacetanilide ((13)C-labeled in the acetyl group) gave virtually the same overall metabolite profile as 3-methyl-4-trifluoromethylaniline; however, a significant level of futile N-deacetylation and reacetylation occurred as ca. 50% of the excreted N-acetylated major metabolites contained no (13)C-label at the acetyl, having been replaced by an endogenous (12)C-acetyl source. This level of futile deacetylation is the highest yet reported for a substituted aniline/acetanilide and indicates a high degree of electronic activation of the amino group toward the acetyltransferase enzymes in vivo.  (+info)

Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: results of an Italian Prostate Cancer Project study. (7/748)

PURPOSE: To compare the efficacy of bicalutamide monotherapy to maximal androgen blockade (MAB) in the treatment of advanced prostatic cancer. PATIENTS AND METHODS: Previously untreated patients with histologically proven stage C or D disease (American Urological Association Staging System) were randomly allocated to receive either bicalutamide or MAB. After disease progression, patients treated with bicalutamide were assigned to castration. The primary end point for this trial was overall survival. Secondary end points included response to treatment, disease progression, treatment safety, quality-of-life (QOL), and sexual function. RESULTS: A total of 108 patients received bicalutamide and 112 received MAB. There was no difference in the percentage of patients whose prostate-specific antigen returned to normal levels. At the time of the present analysis (median follow-up time, 38 months; range, 1 to 60 months), 129 patients progressed and 89 died. There was no difference in the duration of either progression-free survival or overall survival. However, a survival trend favored bicalutamide in stage C disease but MAB in stage D disease. Overall and subgroup trends were confirmed by multivariate analysis. Serious adverse events and treatment discontinuations were more common in patients receiving MAB (P =.08 and P =.04, respectively). Fewer patients in the bicalutamide group complained of loss of libido (P =. 01) and of erectile dysfunction (P =.002). Significant trends favored bicalutamide-treated patients also with respect to their QOL, namely relative to social functioning, vitality, emotional well-being, and physical capacity. CONCLUSION: Bicalutamide monotherapy yielded comparable results relative to standard treatment with MAB, induced fewer side effects, and produced a better QOL.  (+info)

Stimulation of bradykinin B(1) receptors induces vasodilation in conductance and resistance coronary vessels in conscious dogs: comparison with B(2) receptor stimulation. (8/748)

BACKGROUND: Constitutive bradykinin B(1) receptors have been identified in dogs; however, their physiological implications involving the coronary circulation remain to be determined. This study examined, in conscious dogs, the coronary response to des-Arg(9)-bradykinin (a B(1) receptor agonist) and the mechanisms involved. METHODS AND RESULTS: Eleven dogs were instrumented with a left ventricular micromanometer, a circumflex coronary catheter, a cuff occluder, a Doppler flow probe, and ultrasonic crystals to measure coronary blood flow velocity (CBFv) and coronary diameter (CD). Intracoronary des-Arg(9)-bradykinin (3 to 100 ng/kg) and bradykinin (0.1 to 10 ng/kg) did not modify systemic hemodynamics but dose-dependently increased CBFv and CD. Des-Arg(9)-bradykinin was less potent than bradykinin. Hoe 140 (a B(2) antagonist, 10 microg/kg) abolished the effects of bradykinin but did not influence the effects of des-Arg(9)-bradykinin. When CBFv increase was prevented by the cuff occluder, CD responses to bradykinin and des-Arg(9)-bradykinin were maintained. Intracoronary lisinopril (0. 75 mg) increased the CD response to bradykinin, with only minimal effect on CBFv, and extended the duration of the effect. Lisinopril did not alter des-Arg(9)-bradykinin responses. Intracoronary N(omega)-nitro-L-arginine (2 mg/kg) decreased the CD effect of bradykinin and prevented the CBFv and CD effects of des-Arg(9)-bradykinin. The relaxing effect of des-Arg(9)-bradykinin on isolated coronary rings was prevented by des-Arg(9), [Leu(8)]-bradykinin. CONCLUSIONS: In the conscious dog, B(1) receptors are present in coronary vessels, and their stimulation produces vasodilation in conductance and resistance vessels, which is mediated essentially by NO but not modulated by angiotensin-converting enzyme. However, the coronary vasodilation induced by B(1) receptor stimulation is not as great as that produced by B(2) receptor stimulation.  (+info)

BACKGROUND The Hedgehog pathway inhibitor vismodegib has shown clinical benefit in patients with advanced basal cell carcinoma and is approved for treatment of patients with advanced basal cell carcinoma for whom surgery is inappropriate. STEVIE was designed to assess the safety of vismodegib in a situation similar to routine practice, with a long follow-up. METHODS In this multicentre, open-label trial, adult patients with histologically confirmed locally advanced basal cell carcinoma or metastatic basal cell carcinoma were recruited from regional referral centres or specialist clinics. Eligible patients were aged 18 years or older with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, and adequate organ function. Patients with locally advanced basal cell carcinoma had to have been deemed ineligible for surgery. All patients received 150 mg oral vismodegib capsules once a day on a continuous basis in 28-day cycles. The primary objective was safety (incidence of adverse ...
Breaks from treatment with vismodegib enable patients with advanced basal cell carcinoma (aBCC) to remain longer on treatment, according to a study presented here at the 24th European Academy of Dermatology and Venereology (EADV) Congress.. Reinhard Dummer, MD, Dermatologische Klinik, Universitäts Spital, Zurich, Switzerland, and colleagues performed an exploratory analysis of the effect of treatment breaks on patients treated with vismodegib while taking part in the ongoing STEVIE trial.. In the STEVIE trial, patients with aBCC receive vismodegib 150 mg once daily until disease progression, unacceptable toxicity, or withdrawal.. "Treatment breaks are allowed in the STEVIE study for up to 8 weeks for the management of toxicity or temporary inability to swallow capsules," explained Dr. Dummer.. The reasons provided for treatment breaks were intolerable toxicity in 53%, adverse events (AEs) in 23%, patient decision in 9%, and inability to swallow capsules in 5% of patients receiving treatment ...
Among the group with metastatic basal cell cancer, overall response rate was 30%, and stable disease was observed in 63%. For those with locally advanced basal cell carcinoma, overall response rate was 43% and stable disease was observed in 40%. Median progression-free survival at 10 months was identical in the two groups. Absence of basal cell cancer on biopsy was reported in 54% of the cohort with locally advanced disease.. Few serious adverse events were attributed to vismodegib. Of 26 (25%) serious adverse events, 4 (4%) were deemed drug-related. "The common adverse events were predominantly mild to moderate and related to inhibition of the Hedgehog pathway, such as muscle spasms, alopecia, taste disturbance, weight loss, and fatigue," he told listeners. ■. Disclosure: Dr. Horning is Senior Vice President, Global Head of Clinical Development Hematology/Oncology for Genentech. Dr. Dirix reported no potential conflicts of interest.. SIDEBAR: Expert Point of View: Breakthrough Approach to ...
This multi-center, prospective, observational cohort study will evaluate the effectiveness, safety and utilization of treatments in patients with advanced basal cell carcinoma and basal cell carcinoma nevus syndrome. The total study duration is anticipated to be a maximum of 8 years, including 3 years for patient recruitment and 5 years follow-up ...
Novartis International AG / FDA approves Novartis drug Odomzo® (sonidegib) for locally advanced basal cell carcinoma (laBCC), a form of skin cancer . Processed and transmitted by NASDAQ OMX Corporate Solutions. The issuer is solely responsible for the content of this announcement.
Novartis International AG / Pivotal data for Novartis' investigational compound LDE225 show marked tumor responses in advanced basal cell carcinoma . Processed and transmitted by NASDAQ OMX Corporate Solutions. The issuer is solely responsible for the content of this announcement.
Synonyms for anilide in Free Thesaurus. Antonyms for anilide. 3 synonyms for aniline: aminobenzine, aniline oil, phenylamine. What are synonyms for anilide?
Two case might set the stage for the concurrent use of vismodegib and radiotherapy in recurrent advanced basal cell carcinoma (BCC).
This study reports on the efficacy and mechanism of action of the small-molecule multikinase inhibitor foretinib in preclinical models of ovarian cancer metastasis. Our data suggest 4 principal mechanisms for how foretinib inhibits ovarian cancer growth and metastasis. In ovarian cancer cell lines, the inhibitor: (i) blocked activation of c-Met signaling; (ii) reduced proliferation mediated by a G2-M cell-cycle arrest; (iii) induced cell death through a 2-step mechanism in which cells detach followed by a caspase-dependent form of anoikis; and (iv) reduced proliferation, adhesion, migration, and invasion during early tumor development. In mouse models of ovarian cancer metastasis, foretinib reduced tumor burden and metastasis mediated by reduced angiogenesis, proliferation, and increased apoptosis. The multiple activities of foretinib are consistent with the numerous effects that have been attributed to c-Met and angiogenesis in the context of cancer (3).. Foretinib targets c-Met and VEGFR-2 ...
This research study is evaluating a drug called cabozantinib as a possible treatment cancer of the bile duct. Cabozantinib is a drug that targets specific pathways inside the cells of the body. By blocking the c-MET and VEGFR2 pathways from sending signals, cabozantinib may prevent cells from multiplying. This drug has been used in other research studies and information from those other research studies suggests that this drug may help to stop the growth of bile duct cancer.. In this research study, the investigators are looking to see how well cabozantinib works in slowing the growth of bile duct cancer. The investigators are also assessing the safety and tolerability of cabozantinib in participants with this type of cancer. ...
This study is investigating the efficacy of vismodegib [Erivedge] in patients with advanced Basal Cell Carcinoma (BCC) and Gorlin syndrome.
The company has a strong final stage pipeline consisting of more than 35 additional indications for existing products. Moreover, 10 new molecular entities in the areas of cancer, metabolic, autoimmune diseases and CNS disorders are being studied. Roche is one of the leading players in the oncology segment. In 2009, this segment accounted for 53% of total sales. Oncology portfolio revenues rose 8% to CHF 20.7 billion, led by Avastin and other drugs such as Herceptin, MabThera/Rituxan, Tarceva and Xeloda. In order to further strengthen its presence in oncology, the company is developing several new drugs such as pertuzumab and T-DM1 for HER2-positive breast cancer, RG7204 for the treatment of malignant melanoma, GA101/RG7159 for chronic lymphocytic leukemia and non-Hodgkins lymphoma, and RG3616 for the treatment of advanced basal cell carcinoma and potentially other cancers such as colorectal cancer. Results from these candidates are expected over the next two years with the first regulatory ...
Sun Pharmaceutical Industries announced in September the FDA has approved a new label for sonidegib (Odomzo, Novartis), an oral hedgehog inhibitor indicated for the treatment of adults with locally advanced basal cell carcinoma (laBCC) that has recurred following surgery or radiation therapy, or for patients who are not candidates for surgery or radiation therapy. ...
There seems to be some good news for people suffering from advanced basal cell carcinoma as the drug Erivedge has been approved by the FDA to treat this form of skin cancer.
TY - JOUR. T1 - The absolute antipodal activity of analgesics in the basic anilide series. AU - Portoghese, Philip S.. PY - 1962/12. Y1 - 1962/12. UR - http://www.scopus.com/inward/record.url?scp=84883843446&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84883843446&partnerID=8YFLogxK. U2 - 10.1002/jps.2600511221. DO - 10.1002/jps.2600511221. M3 - Article. C2 - 13985627. AN - SCOPUS:84883843446. VL - 51. SP - 1197. EP - 1198. JO - Journal of Pharmaceutical Sciences. JF - Journal of Pharmaceutical Sciences. SN - 0022-3549. IS - 12. ER - ...
Purpose: Vismodegib (GDC-0449) is a potent and selective inhibitor of the Hedgehog (Hh) pathway that shows anti-tumor activity in preclinical models driven by mutational or ligand-dependent activation of the Hh pathway. We wished to characterize the pharmacokinetic-pharmacodynamic relationship of vismodegib in both model systems to guide optimal dose and schedule for vismodegib in the clinic. Experimental Design: Preclinical efficacy and PK/PD studies were performed with vismodegib in a Ptch+/- allograft model of medulloblastoma exhibiting mutational activation of the Hh pathway and patient-derived colorectal cancer (CRC) xenograft models exhibiting ligand-dependent pathway activation. Inhibition of the hedgehog pathway was related to vismodegib levels in plasma and to anti-tumor efficacy using an integrated population-based PK/PD model. Results: Oral dosing of vismodegib caused tumor regressions in the Ptch+/- allograft model of medulloblastoma at doses ≥ 25 mg/kg and tumor growth inhibition ...
Fore Pharma has released its new research, Vismodegib Sales, Price Analysis, & Sales Forecast - 2017. Find out the sales of Vismodegib worldwide and by countries ...
The metabolism and excretion of cabozantinib and its metabolites was studied in 8 healthy male volunteers who received a single oral dose of 140-mg cabozantinib FBE containing 100 µCi 14C-cabozantinib. The mean recovery of total radioactivity was 81.09%, with radioactivity eliminated in feces (53.79%) and urine (27.29%). Total radioactivity eliminated primarily in feces has also been reported in mass balance studies of anticancer RTK inhibitors gefitinib and erlotinib (Mckillop et al., 2004; Ling et al., 2006). Sample collection in our study was extended to 48 days postdose to maximize total 14C-cabozantinib-related radioactivity recovery; however, ,1% of total mean radioactivity was ultimately recovered in feces and urine after day 28 postdose. The total recovery of ,90% of administered 14C-cabozantinib radioactive dose is consistent with reports for mass balance studies of other anticancer drugs with long plasma elimination t1/2 (Beumer et al., 2006).. In the present study, the mean ...
Learn about Cometriq (Cabozantinib Capsules) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
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The FDA approved Odomzo (sonidegib) to treat patients with locally advanced basal cell carcinoma that has recurred following surgery or radiation therapy, or who are not candidates for surgery or radiation therapy. Skin cancer is the most common cancer and basal cell carcinoma accounts for approximately 80 percent of non-melanoma skin cancers. Basal cell carcinoma starts in the top layer of the skin (called the epidermis) and usually develops in areas that have been regularly exposed to the sun and other forms of ultraviolet radiation. - Year:2015
Bicalutamide should be used with caution in patients with moderate-to-severe hepatic impairment. Bicalutamide is extensively metabolized by the liver. Limited data in subjects with severe hepatic impairment suggest that excretion of bicalutamide may be delayed and could lead to further accumulation. Periodic liver function tests should be considered for hepatic-impaired patients on long-term therapy [see Warnings and Precautions (5.1)]. No clinically significant difference in the pharmacokinetics of either enantiomer of bicalutamide was noted in patients with mild-to-moderate hepatic disease as compared to healthy controls. However, the half-life of the R-enantiomer was increased approximately 76% (5.9 and 10.4 days for normal and impaired patients, respectively) in patients with severe liver disease (n=4). ...
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All medicines may cause side effects, but many people have no, or minor, side effects.. Check with your doctor if any of these most common side effects persist or become bothersome:. Diarrhea; dizziness; headache; loss of appetite; nausea; stomach upset or cramps; vomiting.. Seek medical attention right away if any of these severe side effects occur:. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or tarry stools; burning, numbness, tingling, pain, or weakness of the arms, hands, legs, or feet; change in sense of touch or temperature; chest pain; dark urine or change in amount of urine; decreased amount of urine; fainting; fever, chills, or unusual cough; hallucinations; hearing changes (eg, ringing in the ears, hearing loss); inability to move or bear weight on a joint or tendon area; irregular heartbeat; joint pain or swelling; moderate to severe sunburn; mood or mental changes (eg, new or ...
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We document here for the first time that endogenous ligands of PPARgamma may contribute to the protection against renal I/R injury afforded by LPS pretreatment in the rat.
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Bicalutamide (Bic) is often used in androgen deprivation remedy (ADT) for treating prostate cancer. Bicalutamide remedy should be began a...
The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a large number of human cancers. The pharmaceutical industry is currently focused on developing small molecules targeting Smoothened (Smo), a key signaling effector of the HH pathway that regulates the levels and activity of the Gli family of transcription factors. Although one of these compounds, vismodegib, is now FDA-approved for patients with advanced basal cell carcinoma, acquired mutations in Smo can result in rapid relapse. Furthermore, many cancers also exhibit a Smo-independent activation of Gli proteins, an observation that may underlie the limited efficacy of Smo inhibitors in clinical trials against other types of cancer. Thus, there remains a critical need for HH inhibitors with different mechanisms of action, particularly those that act downstream of Smo. Recently, we identified the FDA-approved anti-pinworm compound pyrvinium as ...
The Food and Drug Administration has for the first time approved a drug to treat advanced cases of the most common skin cancer, basal cell carcinoma, the agency announced Monday.. The drug, a capsule called Erivedge (generically known as vismodegib), treats basal cell carcinoma that has metastasized (spread through the body), or that cannot be treated with surgery.. In a clinical study in 96 people, 30 percent of those with locally advanced basal cell carcinoma (which had spread to surrounding tissue), and 43 percent of those with metastatic cancer (which had spread to distant sites in the body) saw their tumors shrink or heal while taking the drug, according to a statement from the FDA. Patients took one pill by mouth each day. Doctors treat non-metastatic cases with surgery, radiation or topical treatments, and have an extremely high success rate. But no other treatments exist for inoperable cases, such as people with tumors that have extended into the brain, or people who would become ...
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The nonsteroidal antiandrogen casodex has been described as a peripherally selective drug for the treatment of prostatic cancer. In this study we determined its activity in various models of hormone-dependent malignancies including those of the prostate and the breast. Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and seminal vesicles and a significant rise of testosterone serum levels as a result of the interference with central feedback mechanisms. The growth of androgen-sensitive human LNCaP/FGC prostate cancer cells was strongly inhibited by casodex. Unlike hydroxyflutamide, casodex was also active in hormone-depleted medium. The inhibitory effect was overcome by addition of testosterone propionate, which indicates an androgen-receptor-mediated mode of action. In rats bearing Dunning R3327-G prostate carcinomas casodex exerted a strong antitumour effect at the beginning of therapy. However, after 4 weeks of treatment ...
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We did a multicentre, parallel-group, pragmatic, non-inferiority, randomised controlled trial at 12 centres in the UK, in which patients were recruited between June 19, 2003, and Feb 22, 2007, with 3 year follow-up from June 26, 2006, to May 26, 2010. Participants of any age were eligible if they had histologically confirmed primary nodular or superficial basal-cell carcinoma at low-risk sites. We excluded patients with morphoeic or recurrent basal-cell carcinoma and those with Gorlin syndrome. Participants were randomly assigned (1:1) via computer-generated blocked randomisation, stratified by centre and tumour type, to receive either imiquimod 5% cream once daily for 6 weeks (superficial) or 12 weeks (nodular), or surgical excision with a 4 mm margin. The randomisation sequence was concealed from study investigators. Because of the nature of the interventions, masking of participants was not possible and masking of outcome assessors was only partly possible. The trial statistician was masked ...
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Journal Article 2019; 39(7): 515-524 PubMed PMID: 30860683 Citation Keywords: Anilides:pharmacology, Animals, Cytochrome P-450 Enzyme Inhibitors:pharmacology, Ellipticines:pharmacokinetics, Humans, Microsomes, Liver:drug effects, Oxidation-Reduction:drug effects, Peroxidases:antagonists & inhibitors, Phenylurea Compounds:pharmacolo. OBJECTIVES: Vandetanib¸ lenvatinib, and cabozantinib are tyrosine kinase inhibitors (TKIs) targeting VEGFR subtypes 1 and 2, EGFR and the RET-tyrosine kinase, thus considered as multiple TKIs. These TKIs have already been approved for treating patients suffering from thyroid cancer and renal cell carcinoma. Ellipticine, a DNA-damaging drug, is another anticancer agent that is effective against certain tumors of the thyroid gland, ovarian carcinoma, breast cancer and osteolytic breast cancer metastasis. Its anticancer efficiency is dictated by its oxidation with cytochrome P450 (CYP) and peroxidase enzymes. A number of studies testing the effectiveness of individual ...
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TY - JOUR. T1 - Direct hydrogenation of amides to alcohols and amines under mild conditions. AU - Balaraman, Ekambaram. AU - Gnanaprakasam, Boopathy. AU - Shimon, Linda J W. AU - Milstein, David. PY - 2010/12/1. Y1 - 2010/12/1. N2 - The selective, direct hydrogenation of amides to the corresponding alcohols and amines with cleavage of the C-N bond was discovered. The expected products of C-O cleavage are not formed (except as traces in the case of anilides). The reaction proceeds under mild pressure and neutral, homogeneous conditions using a dearomatized, bipyridyl-based PNN Ru(II) pincer complex as a catalyst. The postulated mechanism involves metal-ligand cooperation by aromatization- dearomatization of the heteroaromatic pincer core and does not involve hydrolytic cleavage of the amide. The simplicity, generality, and efficiency of this environmentally benign process make it attractive for the direct transformations of amides to alcohols and amines in good to excellent yields.. AB - The ...
The most important group of FDCA conversions is undoubtedly the polymerization. The potential applications of furan-based building blocks for polymer applications has been extensively reviewed by Gandini.[20] A notable example is polyethylene 2,5-furandicarboxylate, but also other polyesters and various polyamides and polyurethanes have been described in literature. Amongst others like Dupont and Corbion,[21] the company Avantium claims to have developed a cost effective route to produce FDCA and the derived polyesters. FDCA has also been applied in pharmacology. It was demonstrated that its diethyl ester had a strong anaesthetic action similar to cocaine. Dicalcium 2,5-furandicarboxylate was shown to inhibit the growth of Bacillus megatorium. Screening studies on FDCA-derived anilides showed their important anti-bacterial action. The diacid itself is a strong complexing agent, chelating such ions as: Ca2+, Cu2+ and Pb2+; it is utilized in medicine to remove kidney stones.[3] HMF is metabolized ...
will present the results. Study E1512 met its primary endpoint, demonstrating significant increases in progression-free survival (PFS) for cabozantinib and the combination of cabozantinib plus erlotinib when individually compared to the erlotinib arm. The median PFS for the combination of cabozantinib and erlotinib was 4.7 months versus 1.9 months for erlotinib alone, a more than two-fold increase that corresponds to a 65% reduction in the risk of disease worsening (hazard ratio [HR]=0.35, 80% CI 0.23-0.52, p=0.0005). The median PFS for cabozantinib monotherapy was 4.2 months versus 1.9 months for erlotinib alone, a more than doubling that corresponds to a 62% reduction in the risk of disease worsening (HR=0.38, 80% CI 0.27-0.55, p=0.0004). Overall survival was a secondary endpoint of the trial. Median OS was 13.3 months for the combination of cabozantinib and erlotinib, and 9.2 months for cabozantinib alone, as compared to 4.1 months for erlotinib alone. These results correspond to a 56% ...
Hi everyone! My dad has hit a few more bumps in the road. It seems that once PC cancer spreads....and you get rid of the spreads...it just keeps coming back in different places. Our doctor says it is a Whole body disease. We got rid of the three tumors between the kidneys this year with 7 months of chemo. Within 1 month...the cancer was already growing...PSA from 0.3 to 1.5. We then switched doctors and facilities and my dad was put on Casodex for the first time. It worked for ONE month-knocking his PSA down to 0.6. Now 3 months later, PSA is back to 4. The doctor thinks the Casodex is not working...we are trying it one more month. Also-he thinks now the cancer is growing in a bone in my dads pelvic/butt area. There was a suspicious spot on the last scan. We get new PSA and a bone scan in 3 weeks ...
1. Primary .alpha.-amino anilides". Journal of Medicinal Chemistry. 22 (10): 1171-1176. doi:10.1021/jm00196a005. MedlinePlus ...
Anilide analgesic. Clinical data. Trade names. Lorcet, Norco, Vicodin, others. Synonyms. Hydrocodone/acetaminophen, hydrocodone ...
Unlike the hormones with which it competes, flutamide is not a steroid; rather, it is a substituted anilide. Hence, it is ...
None of the in vivo or in vitro studies performed with toxic-oil-specific components, such as fatty acid anilides, and esters ... Similar results were obtained after administration of fatty acid anilides. The fact that the first cases of the syndrome were ...
Analgesic potency and acute toxicity of substituted anilides and benzamides. Toxicology and Applied Pharmacology 1971;19(1):20- ...
Screening studies on FDCA-derived anilides showed their important anti-bacterial action. The diacid itself is a strong ...
It is the anilide of 3-hydroxy-2-carboxynaphthalene. Many analogous compounds are known, designated with a differing suffix. ...
Primary amines, aromatic amines, or lithium anilides can also be used as nucleophiles. Protective O-methylation often follows ...
It is classified as both a salicylamide and an anilide. Derivatives of salicylanilide have a variety of pharmacological uses. ...
"Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5". Bioorganic & Medicinal ...
... share an anilide ring structure. The structures can be seen in figure 7, where the anilide ring is coloured red. These three ... Replacing the anilide with an alkene gives weakly active compounds, which can be attributed to the lack of intramolecular ...
Main article: Anilide. Aniline reacts with acyl chlorides such as acetyl chloride to give amides. The amides formed from ... At high temperatures aniline and carboxylic acids react to give the anilides.[15] ... aniline are sometimes called anilides, for example CH3-CO-NH-C6H5 is acetanilide. ...
The effect of PMDTA on lithium anilide is illustrative of PMDTA's complexing power. The complex, [{PhN(H)Li}3·2PMDTA], is ... ISBN 978-3-527-29390-2. Barr, D.; Clegg, W.; Cowton, L.; Horsburgh, L.; Mackenzie, F. M.; Mulvey, R. (1995). "Lithium Anilide ...
The amides formed from aniline are sometimes called anilides, for example CH3-CO-NH-C6H5 is acetanilide. At high temperatures ...
In 2009, Gaunt's group reported a copper catalyzed meta-selective C-H arylation reaction on anilide derivatives. Despite the ... It is compatible with a spectrum of substituted anilide as well as different bisaryliodonium salts. However, the meta- ... selectivity is lost when highly ortho/para-directing methoxy group substitutes one of the meta-hydrogen of the anilide, which ... the arylation occurs exclusively on the meta position on a variety of anilide substrates. Remarkably, the regioselectivity is ...
... as arsenic acid anilide. Also biologist, physician, and pharmacist, Béchamp reported it 40 to 50 times less toxic as a drug ... "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique". Compt. Rend. 56: ...
M. A. Bechamp (1863). "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique ...
The anilide nitrogen is then alkylated by means of sodium hydride and ethyl iodide to give 3. The first step in the ...
It is an anilide derivative and analogue of the NSAA flutamide, and shows greater in vivo antiandrogenic potency than does ...
... is a precursor to many anilides, such as Naphthol AS, which are reactive toward diazonium salts to ...
ISBN 978-0-85404-182-4. N-Phenyl derivatives of primary amides are called 'anilides' and may be named using the term 'anilide' ...
Subsequently, the rate of chemical change was studied in the case of the formation of amides and anilides by the action of ...
... (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of ...
... anilide ("Naphtol AS-PH" dye precursor). In the solid state the hydrazo tautomer forms and several crystal structures exist. In ...
... leading to the thermodynamically preferred β-keto acid anilide product (albeit in less than ideal yields). Continuation of this ...
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
This report provides an update on research on the toxic oil syndrome (‎TOS)‎ since the last WHO review was published in 1992. Although it has been known since the late 1980s that the disease was caused by the consumption of ...
Twenty-three compounds in two series of ferrocene-based anilides, with the general formula C5H5-Fe-C5H4-C6H4-NH-CO-C6H4-R ( ... Twenty-three compounds in two series of ferrocene-based anilides, with the general formula C5H5-Fe-C5H4-C6H4-NH-CO-C6H4-R ( ... Ferrocene-based anilides: synthesis, structural characterization and inhibition of butyrylcholinesterase A. A. Altaf, M. ...
The National Center for Biomedical Ontology was founded as one of the National Centers for Biomedical Computing, supported by the NHGRI, the NHLBI, and the NIH Common Fund under grant U54-HG004028 ...
... acetoacetic acid anilide / acetoacetic acid anilide (ATAN-ATAN): trisodium bis{6-[1-(phenylcarbamoyl)ethylazo]-5-( ... Main component: acetoacetic acid anilide / 3-amino-1-hydroxybenzene (ATAN-MAP): trisodium {6-[(2 or 3 or 4)-amino-(4 or 5 or 6 ...
... IP.com Disclosure Number: IPCOM000051651D Original Publication Date: 1981-Feb-01 Included in ...
SAR toxicity study of some anilide derivatives of Naphthol-AS type. Domenii publicaţii > Chimie + Tipuri publicaţii > Articol ... In this paper, a toxicity study for a series of anilides of Naphthol-AS type is presented. The toxicity of the model compounds ...
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly ...
A family of crystalline lithium anilide solvates, [{PhN(H)Li .(pyr)(2)}(2)] 1, [{PhN(H)Li .(4-Me-pyr)(2)}(2)] 2 and [{PhN(H)Li ... The changing structural chemistry of lithium anilide on solvation by pyridine, 4-methylpyridine or 4-tert-butylpyridine ... The changing structural chemistry of lithium anilide on solvation by pyridine, 4-methylpyridine or 4-tert-butylpyridine. ...
Binding of Anilide-type Local Anesthetics in Human Plasma: I. Relationships between Binding, Physicochemical Properties, and ... Binding of Anilide-type Local Anesthetics in Human Plasma: I. Relationships between Binding, Physicochemical Properties, and ... Binding of Anilide-type Local Anesthetics in Human Plasma: I. Relationships between Binding, Physicochemical Properties, and ... Geoffrey T. Tucker, Robert N. Boyes, Phillip O. Bridenbaugh, Daniel C. Moore; Binding of Anilide-type Local Anesthetics in ...
The reaction of anilide 4 with aromatic aldehydes yielded 10a,b. Also, when anilide 4 was reacted with a mixture of aromatic ... Hussein, A. H. M. , El-Gaby, M. S. A. A. , El-Maged, A. A. H. A. , El-Sharief, A. M. and Ammar, Y. A. (2015). β-Oxo Anilides in ... Similarly, anilide 1 was reacted with cyanoacetamide under the same reaction conditions to yield 4-methyl-2-oxo-6-p-tolylamino- ... Microwave-Assisted Synthesis of New Substituted Anilides of Quinaldic Acid. A QUICK VIEW ON METHODS OF SYNTHESIS OF PYRIMIDINES ...
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Cobalt(II)-catalyzed regioselective C-H halogenation of anilides Ze-lin Li, Kang-kang Sun and Chun Cai ...
N02BE Anilides. N02BE01 Paracetamol N02BE03 Phenacetin N02BE04 Bucetin N02BE05 Propacetamol N02BE51 Paracetamol, combinations ...
The Merck Index* Online - search across all of the entries using text (names, classifications) and numerical (melting point, mol weight, boiling point) queries
Portoghese, P. S. (1962). The absolute antipodal activity of analgesics in the basic anilide series. Journal of Pharmaceutical ... Portoghese, Philip S. / The absolute antipodal activity of analgesics in the basic anilide series. In: Journal of ... Portoghese, PS 1962, The absolute antipodal activity of analgesics in the basic anilide series, Journal of Pharmaceutical ... The absolute antipodal activity of analgesics in the basic anilide series. Journal of Pharmaceutical Sciences. 1962 Dec;51(12): ...
Atorvastatin-(anilide ring-d5) calcium salt. * 1 Product Result * , Match Criteria: Keyword ...
1. Primary .alpha.-amino anilides". Journal of Medicinal Chemistry. 22 (10): 1171-1176. doi:10.1021/jm00196a005. MedlinePlus ...
Anilide analgesic. Clinical data. Trade names. Lorcet, Norco, Vicodin, others. Synonyms. Hydrocodone/acetaminophen, hydrocodone ...
Countercation effect on CO2 binding to oxo titanate with bulky anilide ligands. Albert Paparo, Jared S. Silvia, Thomas P. ... Countercation effect on CO2 binding to oxo titanate with bulky anilide ligands. / Paparo, Albert; Silvia, Jared S.; Spaniol, ... Countercation effect on CO2 binding to oxo titanate with bulky anilide ligands. Chemistry - A European Journal. 2018 Nov 16;24( ... This work focuses on nucleophilic activation of CO2 at the anionic terminal oxo titanium tris(anilide) complexes [(Solv)nM][OTi ...
... anilides such as triclorocarbanilide; biguanides such as chlorhexidine; chlorine-releasing agents such as sodium hypochlorite, ...
Roxicet is a brand name medication included in a group of medications called Anilides. For more information about Roxicet see ...
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Cinnamic Anilides as New Mitochondrial Permeability Transition Pore Inhibitors Endowed with Ischemia-Reperfusion Injury ... cinnamic anilides attenuate opening novel class compound Cinnamic Anilides cinnamic anilide mPTP inhibitors mPTP opening ... In this account, we report the development of a series of substituted cinnamic anilides that represents a novel class of ... The activity of the cinnamic anilide mPTP inhibitors turned out to be additive with that of CsA, suggesting for these ...
b) Insoluble azo-pigments (anilides):. Diazo Yellow, Fast Yellow, G. Fast Yellow 100, Diazo Orange, Vulcan Orange, Ryrazolon ...
  • Preparation of 3-Alkylated Oxindoles from N-Benzyl Aniline via a Cu(II)-Mediated Anilide Cyclization Process. (york.ac.uk)
  • Portoghese, PS 1962, ' The absolute antipodal activity of analgesics in the basic anilide series ', Journal of Pharmaceutical Sciences , vol. 51, no. 12, pp. 1197-1198. (umn.edu)
  • Twenty-three compounds in two series of ferrocene-based anilides, with the general formula C 5 H 5 -Fe-C 5 H 4 -C 6 H 4 -NH-CO-C 6 H 4 -R (where R = H, F, Cl, CH 3 and OCH 3 ), have been successfully synthesized. (rsc.org)
  • Procedures for the determination of phenolic products, and the effects of metyrapone (54364) and related compounds on anilide hydroxylation were investigated. (cdc.gov)
  • Site-Selective Linear Alkylation of Anilides by Cooperative Nickel/Aluminum Catalysis. (nih.gov)
  • 3.The titanocene(II)-promoted inter-and intra-molecular reactions of thioacetals with anilides produced reductive alkylation products, acyclic and cyclic amines, respectively. (nii.ac.jp)
  • Similarly, anilide 1 was reacted with cyanoacetamide under the same reaction conditions to yield 4-methyl-2-oxo-6-p-tolylamino-1,2-dihydro-pyridine-3-carbonitrile 13 in quantitative yield. (oalib.com)
  • In this paper, a toxicity study for a series of anilides of Naphthol-AS type is presented. (ad-astra.ro)
  • In this account, we report the development of a series of substituted cinnamic anilides that represents a novel class of mitochondrial permeability transition pore (mPTP) inhibitors. (figshare.com)
  • In the organic phase the azo-coupling reaction between 4-nitrobenzenediazonium chloride and 3-hydroxy-2-carboxylic acid 2-methyl-anilide (Naphthol AS-D) takes place as coupling component. (hindawi.com)