AnilidesTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Aniline CompoundsVocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Subject Headings: Terms or expressions which provide the major means of access by subject to the bibliographic unit.Aniline Hydroxylase: A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.Unified Medical Language System: A research and development program initiated by the NATIONAL LIBRARY OF MEDICINE to build knowledge sources for the purpose of aiding the development of systems that help health professionals retrieve and integrate biomedical information. The knowledge sources can be used to link disparate information systems to overcome retrieval problems caused by differences in terminology and the scattering of relevant information across many databases. The three knowledge sources are the Metathesaurus, the Semantic Network, and the Specialist Lexicon.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.DNA, Ribosomal: DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.Alcohol Drinking: Behaviors associated with the ingesting of alcoholic beverages, including social drinking.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Alcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)Pregnancy Complications: Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.Pregnancy Outcome: Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.Pregnancy, Animal: The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.Pregnancy, Ectopic: A potentially life-threatening condition in which EMBRYO IMPLANTATION occurs outside the cavity of the UTERUS. Most ectopic pregnancies (>96%) occur in the FALLOPIAN TUBES, known as TUBAL PREGNANCY. They can be in other locations, such as UTERINE CERVIX; OVARY; and abdominal cavity (PREGNANCY, ABDOMINAL).Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.Pregnancy Trimester, First: The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.Sutures: Materials used in closing a surgical or traumatic wound. (From Dorland, 28th ed)Containment of Biohazards: Provision of physical and biological barriers to the dissemination of potentially hazardous biologically active agents (bacteria, viruses, recombinant DNA, etc.). Physical containment involves the use of special equipment, facilities, and procedures to prevent the escape of the agent. Biological containment includes use of immune personnel and the selection of agents and hosts that will minimize the risk should the agent escape the containment facility.Cranial Sutures: A type of fibrous joint between bones of the head.Suture Techniques: Techniques for securing together the edges of a wound, with loops of thread or similar materials (SUTURES).Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Anti-Infective Agents: Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Antimicrobial Cationic Peptides: Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Drug Synergism: The action of a drug in promoting or enhancing the effectiveness of another drug.Vitamin A: Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products.AmidohydrolasesEstersKeratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Retinoids: A group of tetraterpenes, with four terpene units joined head-to-tail. Biologically active members of this class are used clinically in the treatment of severe cystic ACNE; PSORIASIS; and other disorders of keratinization.Receptors, Retinoic Acid: Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Endocannabinoids: Fatty acid derivatives that have specificity for CANNABINOID RECEPTORS. They are structurally distinct from CANNABINOIDS and were originally discovered as a group of endogenous CANNABINOID RECEPTOR AGONISTS.PrintingInsulator Elements: Nucleic acid regulatory sequences that limit or oppose the action of ENHANCER ELEMENTS and define the boundary between differentially regulated gene loci.InkWhiplash Injuries: Hyperextension injury to the neck, often the result of being struck from behind by a fast-moving vehicle, in an automobile accident. (From Segen, The Dictionary of Modern Medicine, 1992)Printers' MarksElectrodes: Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Engraving and EngravingsCryoelectron Microscopy: Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.Hydroxybutyrates: Salts and esters of hydroxybutyric acid.Antirheumatic Agents: Drugs that are used to treat RHEUMATOID ARTHRITIS.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Fraud: Exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter.UridineFusion Proteins, bcr-abl: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.Leukemia, Myelogenous, Chronic, BCR-ABL Positive: Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.Benzamides: BENZOIC ACID amides.Pyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.PiperazinesPyridazinesProtein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.Databases, Pharmaceutical: Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.K562 Cells: An ERYTHROLEUKEMIA cell line derived from a CHRONIC MYELOID LEUKEMIA patient in BLAST CRISIS.

Androgen-independent induction of prostate-specific antigen gene expression via cross-talk between the androgen receptor and protein kinase A signal transduction pathways. (1/748)

Transcription of the prostate-specific antigen (PSA) gene escapes regulation by androgens in advanced prostate cancer. To determine the molecular mechanism(s) of androgen-independent regulation of the PSA gene, the possibility that the androgen receptor (AR) is activated in the absence of androgen by stimulation of protein kinase A (PKA) was investigated. Activation of PKA by forskolin resulted in elevated expression of the PSA gene in androgen-depleted LNCaP cells, an effect that was blocked by the antiandrogen, bicalutamide. Further evidence that induction of PSA gene expression was dependent on AR was obtained from experiments using PC3 cells devoid of AR. Neither PSA, PB, nor ARR3 androgen-responsive reporters could be induced by activation of PKA in the absence of transfected AR. In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. Lastly, cotransfection of an expression vector for a chimeric protein encoding the amino-terminal domain of the human AR linked to Gal4 and a 5xGal4UAS reporter gene construct resulted in activation of the amino-terminal domain of the AR by stimulation of PKA activity. These results demonstrate androgen-independent induction of PSA gene expression in prostate cancer cells by an AR-dependent pathway.  (+info)

Effects of NTE-122, a novel acyl-CoA:cholesterol acyltransferase inhibitor, on cholesterol esterification and secretions of apolipoprotein B-containing lipoprotein and bile acids in HepG2. (2/748)

We studied the effect of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylamino phenyl) ureido]methyl]cyclohexane), a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, on intracellular cholesterol esterification and the secretion of apolipoprotein B100 (apoB)-containing lipoprotein and bile acids in the human hepatoma cell line HepG2. NTE-122 markably inhibited [3H]oleate incorporation into cholesteryl esters in HepG2 cells incubated with 5 microg/ml 25-hydroxycholesterol as a stimulus for ACAT (IC50=6.0 nM). On the other hand, NTE-122 did not affect [3H]oleate incorporation into triglycerides and phospholipids and [14C]acetate incorporation into cholesterol. The stimulation of ACAT by 25-hydroxycholesterol caused significant increases in the secretion of radiolabeled cholesteryl esters, radiolabeled triglycerides and apoB mass. NTE-122 pronouncedly inhibited the secretion of radiolabeled cholesteryl esters in proportion to the inhibition of cellular cholesterol esterification, and it significantly reduced the secretion of radiolabeled triglycerides and apoB mass in HepG2 cells incubated with 25-hydroxycholesterol. Furthermore, NTE-122 increased the secretion of bile acids synthesized from [14C]-cholesterol. These results suggest that NTE-122 is capable of exhibiting anti-hyperlipidemic effects by reducing both the cholesterol content and the amount of secreted very low-density lipoprotein and enhancing the excretion of bile acid from the liver.  (+info)

Metabolism of aminoacyl-p-nitroanilides by rat mammary tissue. (3/748)

We have examined the metabolism of aminoacyl-p-nitroanilides by rat mammary tissue isolated from rats during late pregnancy, peak lactation and late lactation. The rate of hydrolysis depended upon the chemical nature of the aminoacyl-p-nitroanilide compound and the physiological state of the donor animals. Thus, mammary tissue isolated from rats during late pregnancy and peak lactation hydrolysed aminoacyl-p-nitroanilides in the order L-met-p-nitroanilide=L-leu-p-nitroanilide>L-lys-p-nitroanilide>gamma- glu-p-nitroanilide. The order of activity was the same for mammary tissue taken from rats during late lactation except that L-lys-p-nitroanilide was hydrolysed at the same rate as the neutral aminoacyl-p-nitroanilides. Mammary tissue from peak lactating rats also hydrolysed alpha-L-glu-p-nitroanilide and alpha-L-asp-p-nitroanilide but to a lesser extent than the other compounds tested. The anionic aminoacyl-p-nitroanilides were able to trans-stimulate D-aspartate efflux from mammary tissue explants and the perfused mammary gland via the high-affinity anionic amino acid carrier. The clearance of gly-L-phe by the perfused mammary gland was markedly inhibited by L-phe. The results suggest that mammary tissue expresses a variety of dipeptidases at the basolateral aspect of the mammary epithelium which are capable of hydrolysing peptides extracellularly. These enzymes may be important for providing amino acids for milk protein synthesis and/or inactivating signal peptides.  (+info)

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. (4/748)

The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR transcripts and genes from a large series of bone marrow metastases. Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by flutamide. In contrast, the single mutant AR found among 17 patients treated with androgen ablation monotherapy was not flutamide stimulated. Patients with flutamide-stimulated AR mutations responded to subsequent treatment with bicalutamide, an AR antagonist that blocks the mutant ARs. These findings demonstrate that AR mutations occur in response to strong selective pressure from flutamide treatment.  (+info)

Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. (5/748)

Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the development of therapy-resistant tumours, we established a new tumour model which closely resembles the situation in patients who receive androgen ablation therapy. Androgen-sensitive LNCaP cells were kept in androgen-depleted medium for 87 passages. The new LNCaP cell subline established in this manner, LNCaP-abl, displayed a hypersensitive biphasic proliferative response to androgen until passage 75. Maximal proliferation of LNCaP-abl cells was achieved at 0.001 nM of the synthetic androgen methyltrienolone (R1881), whereas 0.01 nM of this compound induced the same effect in parental cells. At later passages (> 75), androgen exerted an inhibitory effect on growth of LNCaP-abl cells. The non-steroidal anti-androgen bicalutamide stimulated proliferation of LNCaP-abl cells. AR protein expression in LNCaP-abl cells increased approximately fourfold. The basal AR transcriptional activity was 30-fold higher in LNCaP-abl than in LNCaP cells. R1881 stimulated reporter gene activity in LNCaP-abl cells even at 0.01 nM, whereas 0.1 nM of R1881 was needed for induction of the same level of reporter gene activity in LNCaP cells. Bicalutamide that acts as a pure antagonist in parental LNCaP cells showed agonistic effects on AR transactivation activity in LNCaP-abl cells and was not able to block the effects of androgen in these cells. The non-steroidal AR blocker hydroxyflutamide exerted stimulatory effects on AR activity in both LNCaP and LNCaP-abl cells; however, the induction of reporter gene activity by hydroxyflutamide was 2.4- to 4-fold higher in the LNCaP-abl subline. The changes in AR activity were associated neither with a new alteration in AR cDNA sequence nor with amplification of the AR gene. Growth of LNCaP-abl xenografts in nude mice was stimulated by bicalutamide and repressed by testosterone. In conclusion, our results show for the first time that the nonsteroidal anti-androgen bicalutamide acquires agonistic properties during long-term androgen ablation. These findings may have repercussions on the natural course of prostate cancer with androgen deprivation and on strategies of therapeutic intervention.  (+info)

Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4-trifluoromethylacetanilide in the rat. (6/748)

The urinary metabolites of 3-methyl-4-trifluoromethylaniline in the rat were characterized and quantified using a combination of (19)F NMR, HPLC-NMR ((1)H and (19)F), and HPLC-mass spectrometry techniques. The major routes of metabolism were amine N-acetylation and methyl group C-oxidation to the benzyl alcohol (with subsequent glucuronide conjugation) and further to the corresponding benzoic acid derivative. Quantitatively only a small proportion of the urinary metabolites contained the free amino group, and these were products of ortho-hydroxylation (2 and 6 position) with additional conjugation to form the ether sulfates and glucuronides. An N-glucuronide of the parent compound was also identified. 3-Methyl-4-trifluoromethylacetanilide ((13)C-labeled in the acetyl group) gave virtually the same overall metabolite profile as 3-methyl-4-trifluoromethylaniline; however, a significant level of futile N-deacetylation and reacetylation occurred as ca. 50% of the excreted N-acetylated major metabolites contained no (13)C-label at the acetyl, having been replaced by an endogenous (12)C-acetyl source. This level of futile deacetylation is the highest yet reported for a substituted aniline/acetanilide and indicates a high degree of electronic activation of the amino group toward the acetyltransferase enzymes in vivo.  (+info)

Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: results of an Italian Prostate Cancer Project study. (7/748)

PURPOSE: To compare the efficacy of bicalutamide monotherapy to maximal androgen blockade (MAB) in the treatment of advanced prostatic cancer. PATIENTS AND METHODS: Previously untreated patients with histologically proven stage C or D disease (American Urological Association Staging System) were randomly allocated to receive either bicalutamide or MAB. After disease progression, patients treated with bicalutamide were assigned to castration. The primary end point for this trial was overall survival. Secondary end points included response to treatment, disease progression, treatment safety, quality-of-life (QOL), and sexual function. RESULTS: A total of 108 patients received bicalutamide and 112 received MAB. There was no difference in the percentage of patients whose prostate-specific antigen returned to normal levels. At the time of the present analysis (median follow-up time, 38 months; range, 1 to 60 months), 129 patients progressed and 89 died. There was no difference in the duration of either progression-free survival or overall survival. However, a survival trend favored bicalutamide in stage C disease but MAB in stage D disease. Overall and subgroup trends were confirmed by multivariate analysis. Serious adverse events and treatment discontinuations were more common in patients receiving MAB (P =.08 and P =.04, respectively). Fewer patients in the bicalutamide group complained of loss of libido (P =. 01) and of erectile dysfunction (P =.002). Significant trends favored bicalutamide-treated patients also with respect to their QOL, namely relative to social functioning, vitality, emotional well-being, and physical capacity. CONCLUSION: Bicalutamide monotherapy yielded comparable results relative to standard treatment with MAB, induced fewer side effects, and produced a better QOL.  (+info)

Stimulation of bradykinin B(1) receptors induces vasodilation in conductance and resistance coronary vessels in conscious dogs: comparison with B(2) receptor stimulation. (8/748)

BACKGROUND: Constitutive bradykinin B(1) receptors have been identified in dogs; however, their physiological implications involving the coronary circulation remain to be determined. This study examined, in conscious dogs, the coronary response to des-Arg(9)-bradykinin (a B(1) receptor agonist) and the mechanisms involved. METHODS AND RESULTS: Eleven dogs were instrumented with a left ventricular micromanometer, a circumflex coronary catheter, a cuff occluder, a Doppler flow probe, and ultrasonic crystals to measure coronary blood flow velocity (CBFv) and coronary diameter (CD). Intracoronary des-Arg(9)-bradykinin (3 to 100 ng/kg) and bradykinin (0.1 to 10 ng/kg) did not modify systemic hemodynamics but dose-dependently increased CBFv and CD. Des-Arg(9)-bradykinin was less potent than bradykinin. Hoe 140 (a B(2) antagonist, 10 microg/kg) abolished the effects of bradykinin but did not influence the effects of des-Arg(9)-bradykinin. When CBFv increase was prevented by the cuff occluder, CD responses to bradykinin and des-Arg(9)-bradykinin were maintained. Intracoronary lisinopril (0. 75 mg) increased the CD response to bradykinin, with only minimal effect on CBFv, and extended the duration of the effect. Lisinopril did not alter des-Arg(9)-bradykinin responses. Intracoronary N(omega)-nitro-L-arginine (2 mg/kg) decreased the CD effect of bradykinin and prevented the CBFv and CD effects of des-Arg(9)-bradykinin. The relaxing effect of des-Arg(9)-bradykinin on isolated coronary rings was prevented by des-Arg(9), [Leu(8)]-bradykinin. CONCLUSIONS: In the conscious dog, B(1) receptors are present in coronary vessels, and their stimulation produces vasodilation in conductance and resistance vessels, which is mediated essentially by NO but not modulated by angiotensin-converting enzyme. However, the coronary vasodilation induced by B(1) receptor stimulation is not as great as that produced by B(2) receptor stimulation.  (+info)

*Tocainide

1. Primary .alpha.-amino anilides". Journal of Medicinal Chemistry. 22 (10): 1171-1176. doi:10.1021/jm00196a005. MedlinePlus ...

*Flutamide

Unlike the hormones with which it competes, flutamide is not a steroid; rather, it is a substituted anilide. Hence, it is ...

*Toxic oil syndrome

None of the in vivo or in vitro studies performed with toxic-oil-specific components, such as fatty acid anilides, and esters ... Similar results were obtained after administration of fatty acid anilides. The fact that the first cases of the syndrome were ...

*LiMAx test

Analgesic potency and acute toxicity of substituted anilides and benzamides. Toxicology and Applied Pharmacology 1971;19(1):20- ...

*2,5-Furandicarboxylic acid

Screening studies on FDCA-derived anilides showed their important anti-bacterial action. The diacid itself is a strong ...

*Naphthol AS

It is the anilide of 3-hydroxy-2-carboxynaphthalene. Many analogous compounds are known, designated with a differing suffix. ...

*Aza-Cope rearrangement

Primary amines, aromatic amines, or lithium anilides can also be used as nucleophiles. Protective O-methylation often follows ...

*Salicylanilide

It is classified as both a salicylamide and an anilide. Derivatives of salicylanilide have a variety of pharmacological uses. ...

*Portmanteau inhibitor

"Design and synthesis of caffeoyl-anilides as portmanteau inhibitors of HIV-1 integrase and CCR5". Bioorganic & Medicinal ...

*Discovery and development of antiandrogens

... share an anilide ring structure. The structures can be seen in figure 7, where the anilide ring is coloured red. These three ... Replacing the anilide with an alkene gives weakly active compounds, which can be attributed to the lack of intramolecular ...

*PMDTA

The effect of PMDTA on lithium anilide is illustrative of PMDTA's complexing power. The complex, [{PhN(H)Li}3·2PMDTA], is ... ISBN 978-3-527-29390-2. Barr, D.; Clegg, W.; Cowton, L.; Horsburgh, L.; Mackenzie, F. M.; Mulvey, R. (1995). "Lithium Anilide ...

*Aniline

The amides formed from aniline are sometimes called anilides, for example CH3-CO-NH-C6H5 is acetanilide. At high temperatures ...

*Meta-selective C-H functionalization

In 2009, Gaunt's group reported a copper catalyzed meta-selective C-H arylation reaction on anilide derivatives. Despite the ... It is compatible with a spectrum of substituted anilide as well as different bisaryliodonium salts. However, the meta- ... selectivity is lost when highly ortho/para-directing methoxy group substitutes one of the meta-hydrogen of the anilide, which ... the arylation occurs exclusively on the meta position on a variety of anilide substrates. Remarkably, the regioselectivity is ...

*Arsanilic acid

... as arsenic acid anilide. Also biologist, physician, and pharmacist, Béchamp reported it 40 to 50 times less toxic as a drug ... "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique". Compt. Rend. 56: ...

*Bechamp reaction

M. A. Bechamp (1863). "de l'action de la chaleur sur l'arseniate d'analine et de la formation d'un anilide de l'acide arsenique ...

*Zaleplon

The anilide nitrogen is then alkylated by means of sodium hydride and ethyl iodide to give 3. The first step in the ...

*AA560

It is an anilide derivative and analogue of the NSAA flutamide, and shows greater in vivo antiandrogenic potency than does ...

*3-Hydroxy-2-naphthoic acid

... is a precursor to many anilides, such as Naphthol AS, which are reactive toward diazonium salts to ...

*Acetanilide

ISBN 978-0-85404-182-4. N-Phenyl derivatives of primary amides are called 'anilides' and may be named using the term 'anilide' ...

*Nikolai Menshutkin

Subsequently, the rate of chemical change was studied in the case of the formation of amides and anilides by the action of ...

*Vorinostat

... (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of ...

*Naphthol Red

... anilide ("Naphtol AS-PH" dye precursor). In the solid state the hydrazo tautomer forms and several crystal structures exist. In ...

*Conrad-Limpach synthesis

... leading to the thermodynamically preferred β-keto acid anilide product (albeit in less than ideal yields). Continuation of this ...

*Aryl-acylamidase

In enzymology, an aryl-acylamidase (EC 3.5.1.13) is an enzyme that catalyzes the chemical reaction an anilide + H2O ⇌ {\ ... displaystyle \rightleftharpoons } a carboxylate + aniline Thus, the two substrates of this enzyme are anilide and H2O, whereas ...

*Avizafone

2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in ...
BACKGROUND The Hedgehog pathway inhibitor vismodegib has shown clinical benefit in patients with advanced basal cell carcinoma and is approved for treatment of patients with advanced basal cell carcinoma for whom surgery is inappropriate. STEVIE was designed to assess the safety of vismodegib in a situation similar to routine practice, with a long follow-up. METHODS In this multicentre, open-label trial, adult patients with histologically confirmed locally advanced basal cell carcinoma or metastatic basal cell carcinoma were recruited from regional referral centres or specialist clinics. Eligible patients were aged 18 years or older with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, and adequate organ function. Patients with locally advanced basal cell carcinoma had to have been deemed ineligible for surgery. All patients received 150 mg oral vismodegib capsules once a day on a continuous basis in 28-day cycles. The primary objective was safety (incidence of adverse ...
Among the group with metastatic basal cell cancer, overall response rate was 30%, and stable disease was observed in 63%. For those with locally advanced basal cell carcinoma, overall response rate was 43% and stable disease was observed in 40%. Median progression-free survival at 10 months was identical in the two groups. Absence of basal cell cancer on biopsy was reported in 54% of the cohort with locally advanced disease.. Few serious adverse events were attributed to vismodegib. Of 26 (25%) serious adverse events, 4 (4%) were deemed drug-related. "The common adverse events were predominantly mild to moderate and related to inhibition of the Hedgehog pathway, such as muscle spasms, alopecia, taste disturbance, weight loss, and fatigue," he told listeners. ■. Disclosure: Dr. Horning is Senior Vice President, Global Head of Clinical Development Hematology/Oncology for Genentech. Dr. Dirix reported no potential conflicts of interest.. SIDEBAR: Expert Point of View: Breakthrough Approach to ...
This multi-center, prospective, observational cohort study will evaluate the effectiveness, safety and utilization of treatments in patients with advanced basal cell carcinoma and basal cell carcinoma nevus syndrome. The total study duration is anticipated to be a maximum of 8 years, including 3 years for patient recruitment and 5 years follow-up ...
Novartis International AG / FDA approves Novartis drug Odomzo® (sonidegib) for locally advanced basal cell carcinoma (laBCC), a form of skin cancer . Processed and transmitted by NASDAQ OMX Corporate Solutions. The issuer is solely responsible for the content of this announcement.
Novartis International AG / Pivotal data for Novartis' investigational compound LDE225 show marked tumor responses in advanced basal cell carcinoma . Processed and transmitted by NASDAQ OMX Corporate Solutions. The issuer is solely responsible for the content of this announcement.
Synonyms for anilide in Free Thesaurus. Antonyms for anilide. 3 synonyms for aniline: aminobenzine, aniline oil, phenylamine. What are synonyms for anilide?
Faces of Skin Cancer gives people affected by advanced skin cancer a place to share their stories and help others understand what it really means to live with this disease.
Vismodegib, a first-in-class inhibitor of the hedgehog signaling pathway is indicated for advanced basal cell carcinoma and is associated with amenorrhea. The mechanism is unknown; it has some features of ovarian failure but preserves ovarian potential through blockading of FSH-receptor-dependent signal transduction. This effect appears to be rapidly reversible upon cessation of therapy. Vismodegib and related compounds may have potential for a role in intervention for gynecologic and endocrine disorders and in therapy for other issues involving FSH-dependent function.. ...
This study reports on the efficacy and mechanism of action of the small-molecule multikinase inhibitor foretinib in preclinical models of ovarian cancer metastasis. Our data suggest 4 principal mechanisms for how foretinib inhibits ovarian cancer growth and metastasis. In ovarian cancer cell lines, the inhibitor: (i) blocked activation of c-Met signaling; (ii) reduced proliferation mediated by a G2-M cell-cycle arrest; (iii) induced cell death through a 2-step mechanism in which cells detach followed by a caspase-dependent form of anoikis; and (iv) reduced proliferation, adhesion, migration, and invasion during early tumor development. In mouse models of ovarian cancer metastasis, foretinib reduced tumor burden and metastasis mediated by reduced angiogenesis, proliferation, and increased apoptosis. The multiple activities of foretinib are consistent with the numerous effects that have been attributed to c-Met and angiogenesis in the context of cancer (3).. Foretinib targets c-Met and VEGFR-2 ...
This research study is evaluating a drug called cabozantinib as a possible treatment cancer of the bile duct. Cabozantinib is a drug that targets specific pathways inside the cells of the body. By blocking the c-MET and VEGFR2 pathways from sending signals, cabozantinib may prevent cells from multiplying. This drug has been used in other research studies and information from those other research studies suggests that this drug may help to stop the growth of bile duct cancer.. In this research study, the investigators are looking to see how well cabozantinib works in slowing the growth of bile duct cancer. The investigators are also assessing the safety and tolerability of cabozantinib in participants with this type of cancer. ...
The company has a strong final stage pipeline consisting of more than 35 additional indications for existing products. Moreover, 10 new molecular entities in the areas of cancer, metabolic, autoimmune diseases and CNS disorders are being studied. Roche is one of the leading players in the oncology segment. In 2009, this segment accounted for 53% of total sales. Oncology portfolio revenues rose 8% to CHF 20.7 billion, led by Avastin and other drugs such as Herceptin, MabThera/Rituxan, Tarceva and Xeloda. In order to further strengthen its presence in oncology, the company is developing several new drugs such as pertuzumab and T-DM1 for HER2-positive breast cancer, RG7204 for the treatment of malignant melanoma, GA101/RG7159 for chronic lymphocytic leukemia and non-Hodgkins lymphoma, and RG3616 for the treatment of advanced basal cell carcinoma and potentially other cancers such as colorectal cancer. Results from these candidates are expected over the next two years with the first regulatory ...
Sun Pharmaceutical Industries announced in September the FDA has approved a new label for sonidegib (Odomzo, Novartis), an oral hedgehog inhibitor indicated for the treatment of adults with locally advanced basal cell carcinoma (laBCC) that has recurred following surgery or radiation therapy, or for patients who are not candidates for surgery or radiation therapy. ...
There seems to be some good news for people suffering from advanced basal cell carcinoma as the drug Erivedge has been approved by the FDA to treat this form of skin cancer.
Cabozantinib interferes with the growth of some cancer cells. Cabozantinib is used to treat thyroid cancer that has spread to other parts of the body. Cabozantinib may also be used for purposes not listed in this medication guide.
Purpose: Vismodegib (GDC-0449) is a potent and selective inhibitor of the Hedgehog (Hh) pathway that shows anti-tumor activity in preclinical models driven by mutational or ligand-dependent activation of the Hh pathway. We wished to characterize the pharmacokinetic-pharmacodynamic relationship of vismodegib in both model systems to guide optimal dose and schedule for vismodegib in the clinic. Experimental Design: Preclinical efficacy and PK/PD studies were performed with vismodegib in a Ptch+/- allograft model of medulloblastoma exhibiting mutational activation of the Hh pathway and patient-derived colorectal cancer (CRC) xenograft models exhibiting ligand-dependent pathway activation. Inhibition of the hedgehog pathway was related to vismodegib levels in plasma and to anti-tumor efficacy using an integrated population-based PK/PD model. Results: Oral dosing of vismodegib caused tumor regressions in the Ptch+/- allograft model of medulloblastoma at doses ≥ 25 mg/kg and tumor growth inhibition ...
Cabozantinib (XL184, BMS-907351)は一種の有効なVEGFR2阻害剤で、無細胞試験でIC50値が0.035 nMです。Cabozantinib (XL184, BMS-907351)はc-Met、 Ret、 Kit、Flt-1/3/4、Tie2和AXLに有効に作用する時のIC50値が1.3 nM,4 nM,4.6 nM,12 nM/11.3 nM/6 nM,14.3 nM 和 7 nMにそれぞれ分かれます。
The metabolism and excretion of cabozantinib and its metabolites was studied in 8 healthy male volunteers who received a single oral dose of 140-mg cabozantinib FBE containing 100 µCi 14C-cabozantinib. The mean recovery of total radioactivity was 81.09%, with radioactivity eliminated in feces (53.79%) and urine (27.29%). Total radioactivity eliminated primarily in feces has also been reported in mass balance studies of anticancer RTK inhibitors gefitinib and erlotinib (Mckillop et al., 2004; Ling et al., 2006). Sample collection in our study was extended to 48 days postdose to maximize total 14C-cabozantinib-related radioactivity recovery; however, ,1% of total mean radioactivity was ultimately recovered in feces and urine after day 28 postdose. The total recovery of ,90% of administered 14C-cabozantinib radioactive dose is consistent with reports for mass balance studies of other anticancer drugs with long plasma elimination t1/2 (Beumer et al., 2006).. In the present study, the mean ...
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Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
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The FDA approved Odomzo (sonidegib) to treat patients with locally advanced basal cell carcinoma that has recurred following surgery or radiation therapy, or who are not candidates for surgery or radiation therapy. Skin cancer is the most common cancer and basal cell carcinoma accounts for approximately 80 percent of non-melanoma skin cancers. Basal cell carcinoma starts in the top layer of the skin (called the epidermis) and usually develops in areas that have been regularly exposed to the sun and other forms of ultraviolet radiation. - Year:2015
Bicalutamide should be used with caution in patients with moderate-to-severe hepatic impairment. Bicalutamide is extensively metabolized by the liver. Limited data in subjects with severe hepatic impairment suggest that excretion of bicalutamide may be delayed and could lead to further accumulation. Periodic liver function tests should be considered for hepatic-impaired patients on long-term therapy [see Warnings and Precautions (5.1)]. No clinically significant difference in the pharmacokinetics of either enantiomer of bicalutamide was noted in patients with mild-to-moderate hepatic disease as compared to healthy controls. However, the half-life of the R-enantiomer was increased approximately 76% (5.9 and 10.4 days for normal and impaired patients, respectively) in patients with severe liver disease (n=4). ...
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All medicines may cause side effects, but many people have no, or minor, side effects.. Check with your doctor if any of these most common side effects persist or become bothersome:. Dizziness; drowsiness; lightheadedness; nasal congestion; tiredness; weakness.. Seek medical attention right away if any of these severe side effects occur:. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; irregular heartbeat; prolonged, painful erection; severe or prolonged dizziness or headache; shortness of breath; swelling of the ankles, feet, or hands; vision changes.. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. ...
Curis, Inc. Announces Collaborator Roches Submission of Marketing Authorization Application for Vismodegib in Advanced Basal Cell Carcinoma - read this article along with other careers information, tips and advice on BioSpace
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The Hedgehog (HH) signaling pathway represents an important class of emerging developmental signaling pathways that play critical roles in the genesis of a large number of human cancers. The pharmaceutical industry is currently focused on developing small molecules targeting Smoothened (Smo), a key signaling effector of the HH pathway that regulates the levels and activity of the Gli family of transcription factors. Although one of these compounds, vismodegib, is now FDA-approved for patients with advanced basal cell carcinoma, acquired mutations in Smo can result in rapid relapse. Furthermore, many cancers also exhibit a Smo-independent activation of Gli proteins, an observation that may underlie the limited efficacy of Smo inhibitors in clinical trials against other types of cancer. Thus, there remains a critical need for HH inhibitors with different mechanisms of action, particularly those that act downstream of Smo. Recently, we identified the FDA-approved anti-pinworm compound pyrvinium as ...
The Food and Drug Administration has for the first time approved a drug to treat advanced cases of the most common skin cancer, basal cell carcinoma, the agency announced Monday.. The drug, a capsule called Erivedge (generically known as vismodegib), treats basal cell carcinoma that has metastasized (spread through the body), or that cannot be treated with surgery.. In a clinical study in 96 people, 30 percent of those with locally advanced basal cell carcinoma (which had spread to surrounding tissue), and 43 percent of those with metastatic cancer (which had spread to distant sites in the body) saw their tumors shrink or heal while taking the drug, according to a statement from the FDA. Patients took one pill by mouth each day. Doctors treat non-metastatic cases with surgery, radiation or topical treatments, and have an extremely high success rate. But no other treatments exist for inoperable cases, such as people with tumors that have extended into the brain, or people who would become ...
The nonsteroidal antiandrogen casodex has been described as a peripherally selective drug for the treatment of prostatic cancer. In this study we determined its activity in various models of hormone-dependent malignancies including those of the prostate and the breast. Analysis of endocrine effects in rats after 15 days of treatment revealed a strong reduction of the weights of prostates and seminal vesicles and a significant rise of testosterone serum levels as a result of the interference with central feedback mechanisms. The growth of androgen-sensitive human LNCaP/FGC prostate cancer cells was strongly inhibited by casodex. Unlike hydroxyflutamide, casodex was also active in hormone-depleted medium. The inhibitory effect was overcome by addition of testosterone propionate, which indicates an androgen-receptor-mediated mode of action. In rats bearing Dunning R3327-G prostate carcinomas casodex exerted a strong antitumour effect at the beginning of therapy. However, after 4 weeks of treatment ...
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Generic Casodex is a popular treatment which is also known under the name Generic Bicalutamide. It prevents the androgen activity androgens are the male hormones in human body.
Regulatory News: Exelixis, Inc. (NASDAQ: EXEL) and Ipsen (Euronext: IPN; ADR: IPSEY) today jointly announced an exclusive licensing agreement for the commercialization and further development of cabozantinib, Exelixis lead oncology drug. Under the agreement, Ipsen will have exclusive commercialization rights for current and potential future cabozantinib indications outside the United States, Canada and Japan, including COMETRIQ®, which is currently approved in the European Union (EU) for the treatment of adult patients with progressive, unresectable, locally advanced or metastatic medullary thyroid cancer (MTC). The companies have agreed to collaborate on the development of cabozantinib for current and potential future indications. Exelixis will maintain exclusive commercial rights for cabozantinib in the United States and Canada, and continue its discussions to partner commercial rig
We did a multicentre, parallel-group, pragmatic, non-inferiority, randomised controlled trial at 12 centres in the UK, in which patients were recruited between June 19, 2003, and Feb 22, 2007, with 3 year follow-up from June 26, 2006, to May 26, 2010. Participants of any age were eligible if they had histologically confirmed primary nodular or superficial basal-cell carcinoma at low-risk sites. We excluded patients with morphoeic or recurrent basal-cell carcinoma and those with Gorlin syndrome. Participants were randomly assigned (1:1) via computer-generated blocked randomisation, stratified by centre and tumour type, to receive either imiquimod 5% cream once daily for 6 weeks (superficial) or 12 weeks (nodular), or surgical excision with a 4 mm margin. The randomisation sequence was concealed from study investigators. Because of the nature of the interventions, masking of participants was not possible and masking of outcome assessors was only partly possible. The trial statistician was masked ...
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Casodex: Bicalutamide belongs to a group of medications known as nonsteroidal antiandrogens. Nonsteroidal antiandrogens such as bicalutamide block the effect of the male hormone testosterone in the body.
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TY - JOUR. T1 - Direct hydrogenation of amides to alcohols and amines under mild conditions. AU - Balaraman, Ekambaram. AU - Gnanaprakasam, Boopathy. AU - Shimon, Linda J W. AU - Milstein, David. PY - 2010/12/1. Y1 - 2010/12/1. N2 - The selective, direct hydrogenation of amides to the corresponding alcohols and amines with cleavage of the C-N bond was discovered. The expected products of C-O cleavage are not formed (except as traces in the case of anilides). The reaction proceeds under mild pressure and neutral, homogeneous conditions using a dearomatized, bipyridyl-based PNN Ru(II) pincer complex as a catalyst. The postulated mechanism involves metal-ligand cooperation by aromatization- dearomatization of the heteroaromatic pincer core and does not involve hydrolytic cleavage of the amide. The simplicity, generality, and efficiency of this environmentally benign process make it attractive for the direct transformations of amides to alcohols and amines in good to excellent yields.. AB - The ...
will present the results. Study E1512 met its primary endpoint, demonstrating significant increases in progression-free survival (PFS) for cabozantinib and the combination of cabozantinib plus erlotinib when individually compared to the erlotinib arm. The median PFS for the combination of cabozantinib and erlotinib was 4.7 months versus 1.9 months for erlotinib alone, a more than two-fold increase that corresponds to a 65% reduction in the risk of disease worsening (hazard ratio [HR]=0.35, 80% CI 0.23-0.52, p=0.0005). The median PFS for cabozantinib monotherapy was 4.2 months versus 1.9 months for erlotinib alone, a more than doubling that corresponds to a 62% reduction in the risk of disease worsening (HR=0.38, 80% CI 0.27-0.55, p=0.0004). Overall survival was a secondary endpoint of the trial. Median OS was 13.3 months for the combination of cabozantinib and erlotinib, and 9.2 months for cabozantinib alone, as compared to 4.1 months for erlotinib alone. These results correspond to a 56% ...
Hi everyone! My dad has hit a few more bumps in the road. It seems that once PC cancer spreads....and you get rid of the spreads...it just keeps coming back in different places. Our doctor says it is a Whole body disease. We got rid of the three tumors between the kidneys this year with 7 months of chemo. Within 1 month...the cancer was already growing...PSA from 0.3 to 1.5. We then switched doctors and facilities and my dad was put on Casodex for the first time. It worked for ONE month-knocking his PSA down to 0.6. Now 3 months later, PSA is back to 4. The doctor thinks the Casodex is not working...we are trying it one more month. Also-he thinks now the cancer is growing in a bone in my dads pelvic/butt area. There was a suspicious spot on the last scan. We get new PSA and a bone scan in 3 weeks ...
Casodex is one of the drugs that are considered almost the last chance, the last hope for salvation. After all, prostate cancer very often takes away all the strength of the patient and does not leave any chance of a light at the end of the tunnel. Casodex was created for such patients, which is prescribed only for monotherapy, for the treatment of radical type of prostatectomy, prostate cancer.
AR was previously thought to antagonize ER activity because androgens such as DHT diminished the transcriptional and proliferative response of breast cancer cells to E2 (2), likely because AR and ER compete for some of the same binding sites on chromatin. However, our previous and current studies indicate that DHT is proliferative in the context of no E2, as would be the case in a postmenopausal woman treated with AIs (14). The AR antagonist bicalutamide has also been shown to increase E2-induced ER activity (2). But unlike bicalutamide, enzalutamide and MJC13 are newer generation anti-androgens that inhibit AR nuclear localization, and this is the first study to test the effects of new-generation AR inhibitors on ER chromatin binding. By inhibiting AR nuclear localization or decreasing AR expression by shRNA, we have discovered that AR supports ER genome binding and activity in breast cancer.. In response to E2, AR translocated to the nucleus in ER+ cell lines and bound chromatin at sites that ...
Bicalutamide was selected in this trial chiefly because of its proven efficacy and long-term safety profile in the treatment setting. Differently from finasteride, bicalutamide directly interacts with the androgen receptor, thereby neutralizing the potentially detrimental testosterone surge that is observed during treatment. Moreover, at the daily dose of 50 to 150 mg, bicalutamide was found to decrease the incidence and extent of HG-PIN in pilot trials (22, 23), thus predicting a beneficial modulation of prostate carcinogenesis in at-risk subjects. Finally, its pharmacodynamic and pharmacokinetic properties (9, 10) justified a once-a-week administration with 50 to 100 mg in an attempt to retain activity while substantially reducing toxicity. Subject selection was based on the notion that men with elevated circulating PSA and negative, noncancer biopsy findings constitute a suitable and relatively large population at higher risk of developing prostate cancer, for whom no intervention is ...
The IUPHAR/BPS Guide to Pharmacology. vismodegib ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
In a comparison study, cabozantinib significantly boosted progression-free survival (PFS) against everolimus in patients with renal cell carcinoma (RCC) regardless of metastases degree, type, number of prior treatments, or patient risk status.
The Erivedge drug is intended for use in patients with locally advanced basal cell cancer who are not candidates for surgery or radiation and for patients whose cancer has spread to other parts of the body (metastatic).
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Encainide reduces the number premature heart beats (PVCs) is persons who have had heart attacks. PVCs are strongly associated with a higher risk of death after a heart attack. Unfortunately, patients who took encainide after heart attacks were much more likely to die. It is estimated that encainide caused thousands of excess deaths ...
This phase II trial studies how well vismodegib works in treating younger patients with recurrent or refractory medulloblastoma. Vismodegib may slow the growth of tumor cells. Stanford is currently not accepting patients for this trial.. ...
Study About the BCNs. This Phase II double-blind, randomized, placebo-controlled, two arms enrolled multicenter clinical study of vismodegib BCNs 41 patients from September 2009 to January 2011 was developed, the safety and efficacy of 150 mg daily oral vismodegib versus … Continue reading →. ...
The authors of the study conclude that "A pooled analysis of two phase 3 trials assessing ramucirumab as second-line treatment in patients with HCC following first-line sorafenib (REACH-2 and REACH) demonstrates a significant and clinically meaningful benefit with a favorable safety profile in HCC patients with baseline AFP ≥400 ng/mL.". See the webcast from this presentation. ...
A randomized double-blind phase 2 trial comparing the medications in 375 mCRPC patients showed that the 184 patients treated with enzalutamide had a significantly longer median progression-free survival (the primary trial endpoint) than the 191 bicalutamide recipients (15.7 vs. 5.8 months), reported investigator D. Robert Siemens, MD, of Queens University in Kingston, Ontario. This difference translated into a 56% decreased risk of progression. In addition, the median time to PSA progression was significantly longer in the enzalutamide than bicalutamide group (19.4 vs. 5.8 months). A 50% or greater PSA response was achieved in 82.1% of the enzalutamide group compared with 20.9% of the bicalutamide group. The enzalutamide group had a higher rate of serious adverse events (31.1% vs. 23.3 ...
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In 2012, two landmark phase II studies were reported in the New England Journal of Medicine investigating the use of the firstin- class, small-molecule SMO inhibitor vismodegib (GDC-0449, Genentech) for treatment of advanced BCC (both metastatic and locally advanced) and for management of patients with basal cell nevus syndrome (BCNS). By targeting the HH pathway, it was hoped that these medications could lead to lesion resolution and prevent the development of new BCC lesions. Both studies met their primary endpoints in terms of anti-BCC efficacy, although the studies demonstrated a moderate toxicity profile for the medication.. Sekulic and coworkers evaluated the efficacy and safety profile of vismodegib in BCC patients who were inappropriate surgical candidates given the low likelihood of cure or potential disfigurement of surgery. Of the 104 patients enrolled in the nonrandomized study, 33 had metastatic BCC, while 71 had locallyadvanced disease. Patients received vismodegib 150 mg daily by ...
Androgen Receptor (AR) antagonists have been used in clinic to treat prostate cancer. One example is bicalutamide (Casodex®), which is used along with castration to treat advanced prostate cancer. Unfortunately, the patients developed resistance to bicalutamide (alone or in combination therapy) after only 0.5-2 years of treatment, resulting in castration-resistant prostate cancer (CRPC). Elevated AR expression in tumor cells correlates with a change in the functional activity of bicalutamide from antagonist to agonist, suggesting that prostate tumors may adapt to survive on any residual agonism. MDV3100, a more potent AR antagonist (∼5x vs bicalutamide) without residual agonism, has demonstrated excellent efficacy in CRPC patients and has been approved by FDA for treating CRPC in clinic. Recently, AR antagonists demonstrated anti-tumor activities in preclinical AR+ breast cancer models. Approximately 75% of invasive breast cancers were founded to be AR+.. Although MDV3100 is generally ...
Foretinib (Exelixis, GlaxoSmithKline) (XL-880) CAS No.:849217-64-7, 937176-80-2 Formula:C34H34F2N4O6 M.Wt:632.24 GSK1363089, XL880 1-N-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-1-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Foretinib is an experimental drug candidate for the treatment of cancer.[1] It was discovered by Exelixis and is under development by GlaxoSmithKline.[2] It is currently in Phase II clinical trials.[3] As of December 2012 no phase III trials are registered.[3] Foretinib is an…
Health, ...SCOTTSDALE Ariz. Feb 1 2012 A new skin cancer drug tested for the ...Vismodegib (GDC-0449) was administered for the first time in the world...The drug is the first to receive FDA approval to treat inoperable basa...Vismodegib is used to treat adult patients with advanced basal cell ca...,FDA,approves,new,skin,cancer,drug,first,tested,in,Arizona,by,Scottsdale,Healthcare,and,TGen,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
The IUPHAR/BPS Guide to Pharmacology. bicalutamide ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs.
This trial evaluated the possible drug-drug interactions between cabozantinib and esomeprazole in healthy volunteers. The pharmacokinetics of cabozantinib were
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Liver problems may occur while you are taking this medicine. Stop using this medicine and check with your doctor right away if you are having more than one of these symptoms: clay-colored stools; dark urine; fever; headache; loss of appetite; nausea and vomiting; pain or tenderness in the upper right side of the stomach; unusual tiredness or weakness; or yellow eyes or skin. This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. If you have questions about this, talk to your doctor. Using this medicine with an LHRH analog may affect blood sugar levels. If you notice a change in the results of your blood sugar tests or if you have any questions, check with your doctor. This medicine may affect the results of the prostate specific antigen (PSA) test, which may be used to detect prostate cancer. Make sure you tell all of your doctors that you are using this medicine. If you plan to have children, talk with your doctor before using this medicine. This ...
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The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.
Enzalutamide is an oral androgen-receptor inhibitor approved for patients with mCRPC. Bicalutamide is a non-steroidal oral anti-androgen that is approved for use in conjunction with luteinizing hormone-releasing hormone (LHRH) analogues in men with hormone-treatment naïve prostate cancer. "Despite the widespread use of bicalutamide, evidence of its clinical benefits is scarce in the context of castration-resistant prostate cancer," Neal D. Shore, MD, of Carolina Urologic Research Center in Myrtle Beach, S.C., and colleagues stated in an online report in Lancet Oncology ...
The safety and effectiveness of bicalutamide in pediatric patients have not been established.. Bicalutamide orodispersible tablet was studied in combination with Anastrozole orodispersible tablet in an open-label, non-comparative, multi-center study that assessed the efficacy and safety of this combination regimen over 12 months in the treatment of gonadotropin-independent precocious puberty in boys with familial male-limited precocious puberty, also known as testotoxicosis. Patients were enrolled in the study if they had a baseline age ≥ 2 years and a diagnosis of testotoxicosis based on clinical features of progressive precocious puberty, symmetrical testicular enlargement, advanced bone age, pubertal levels of serum testosterone, prepubertal pattern of gonadotropin secretion following a GnRH stimulation test, and absence of other clinical and biochemical causes of testosterone excess. Thirteen out of the 14 patients enrolled completed 12 months of combination treatment (one patient was lost ...
Bicalutamide (BIC) is an alternative treatment to castration for advanced prostate cancer. Breast events are common adverse effects which can be effectively prevented by the concurrent administration of tamoxifen, a selective estrogen receptor modula
2-Hydrazinyl-N-(4-sulfamoylphenyl)acetamide 3 was the key intermediate for the synthesis of novel hydrazones 4-10 and pyrazole derivatives 11-17. All compounds were tested for their in vivo anti-inflammatory activity and their ability to inhibit the production of PGE2 in serum samples of rats. IC50 values for the most active compounds for inhibition of COX-1 and COX-2 enzymes were determined in vitro, and they were also tested for their ulcerogenic effect. Molecular docking was performed on the active site of COX-2 to predict their mode of binding to the amino acids. Most of the synthesized compounds showed good anti-inflammatory activity especially compounds 3, 4, 8, 9, 15, and 17 which showed better activity than diclofenac as the reference drug. Compounds 3, 8, 9, 13, and 15-17 were less ulcerogenic than indomethacine as the reference drug. Most of the synthesized compounds interacted with Tyr 385 and Ser 530 in molecular docking study with additional hydrogen bond for compound 17. Compound ...
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Materials and methods: The model used is a xenograft originating from the Gleason-9 primary prostate cancer of a 54-years old patient (DePinieux et al, Am J Pathol, 2001). PAC120 is hormone dependent, with no AR mutation. For testing hormone deprivation efficacy, swiss Nu/nu male 8-12 week old mice received the subcutaneous transplantation of PAC120 trocar pieces. Hormonal therapies tested were: inhibitors of AR (flutamide or bicalutamide), GnRH antagonist (degarelix) alone or combined with bicalutamide or trastuzumab (antibody against HER2-ERBB2), compared with surgical castration. Flutamide and bicalutamide were administered continuously orally at 50mg/kg daily, degarelix at a dose of 10mg/kg monthly sub-cutaneously, and trastuzumab at a dose of 10 mg/kg weekly by intraperitoneal injection ...
Evidence-based recommendations on vismodegib (Erivedge) for treating basal cell carcinoma (BCC; non-melanoma skin cancer; rodent ulcers) in adults
SAN DIEGO, Calif. and CAMBRIDGE, Mass., Apr 13, 2008 (PrimeNewswire via COMTEX) -- Infinity Pharmaceuticals, Inc. (Nasdaq:INFI) today announced that preclinical studies evaluating IPI-926, Infinitys novel Hedgehog pathway inhibitor, demonstrated that the compound has excellent pharmaceutical properties in vivo, including oral bioavailability, potent inhibition of the Hedgehog pathway, and long plasma and tumor half-life. Notably, in a novel mouse model of medulloblastoma, once-daily dose administration of IPI-926 resulted in 100 percent survival during the treatment period. These data were reported in an oral presentation today by Melissa Pink, a research investigator at Infinity, during the Annual Meeting of the American Association of Cancer Research (AACR) in San Diego, California.. IPI-926 is a novel, proprietary derivative of the natural plant product cyclopamine that binds to the Smoothened receptor to inhibit the Hedgehog pathway. When abnormally activated in adults, the Hedgehog pathway ...
The panelists, Robert A. Figlin, MD; Sandy Srinivas, MD; and Nizar M. Tannir, MD, FACP, assess clinical trial data regarding novel renal cell carcinoma (RCC) agents, lenvatinib and cabozantinib.
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The Global Basal cell Carcinoma Therapeutics Market 2018-2022 report has been added to ResearchAndMarkets.coms offering. The basal cell carcinoma therapeutics market will register a CAGR of around 6% by 2022. The advancements in the field of oncology research...
A basal cell carcinoma skin cancer is the consequence of sun harm to the skin. The cancer has a tendency to grow in a gradual example. It has the ability to spread to the tissue adjacent. Be that as it may, it cant spread to the inaccessible piece of the body.. The best and the best way to recognize this cancer is to go for a biopsy. The method includes evacuation of a little bit of the skin and letting a pathologist break down it under the magnifying lens in a medical research facility.. The procedure does not work towards evacuating the cancer. It just takes off at the top simply like the tip of an ice sheet. In some cases, the skin lives up to expectations towards recuperating once the biopsy is done as it begins becoming once again the cancer.. Causes. Presently, this does not show that the cancer is no more. It just implies that the cancer is secured with a layer of skin. On the off chance that, the cancer is not dispensed with totally, it can get somewhere down into the skin and results ...
Arraystar LncPath™ Hedgehog Pathway Microarray profiles the expression of the LncRNAs in the Hedgehog pathway and potential mRNA targets,to gain insights into the regulatory mechanisms of the LncRNAs in the Hedgehog pathway.
Grade I drug-related side effects, not requiring further treatment, were reported by all patients in this series. These included muscle spasms, weight loss, dysgeusia, alopecia, decreased appetite, and fatigue. Five patients also reported grade II side effects, but no patients developed grade III or higher adverse effects, although such side effects have been reported.(5) Grade II side effects are defined as moderate ones, with minimal, local or noninvasive intervention indicated; they may limit age-appropriate daily activities. Grade III side effects are defined as severe or medically significant ones; they may be disabling but not immediately life threatening, and they may require hospitalization. Another consideration that led to discontinuation of therapy by 2 patients in the series is the cost of vismodegib, which is approximately $7,500 per month.(2) Overall, hedgehog pathway-targeted therapy, such as vismodegib, can be considered for a population of patients with locally advanced BCC or ...
Grade I drug-related side effects, not requiring further treatment, were reported by all patients in this series. These included muscle spasms, weight loss, dysgeusia, alopecia, decreased appetite, and fatigue. Five patients also reported grade II side effects, but no patients developed grade III or higher adverse effects, although such side effects have been reported.(5) Grade II side effects are defined as moderate ones, with minimal, local or noninvasive intervention indicated; they may limit age-appropriate daily activities. Grade III side effects are defined as severe or medically significant ones; they may be disabling but not immediately life threatening, and they may require hospitalization. Another consideration that led to discontinuation of therapy by 2 patients in the series is the cost of vismodegib, which is approximately $7,500 per month.(2) Overall, hedgehog pathway-targeted therapy, such as vismodegib, can be considered for a population of patients with locally advanced BCC or ...
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The gist: A drug called cabozantinib doesnt do any better than a steroid treatment when it comes to relieving bone pain in men with metastatic castration-resistant prostate cancer. That was the conclusion of a recent clinical trial that tested the drug in volunteer patients. The trial enrolled men who were suffering from moderate to severe pain despite optimized narcotic medication, and whose cancer had worsened after treatment with docetaxel as well as abiraterone and/or enzalutamide. Some of the men in the trial were treated with cabozantinib, and some with the steroid treatment mitoxantrone/prednisone.. "Exelixis (EXEL) announced Monday that treatment with cabozantinib failed to alleviate bone pain compared to a steroid control in men with advanced, metastatic prostate cancer. A negative outcome from the so-called COMET-2 prostate cancer study of cabozantinib was widely expected given the previously announced failure of the COMET-1 study in September. Still, Exelixis shares fell another 10% ...
The investigational drug cabozantinib is showing promise in the treatment of metastatic, hormone-refractory prostate cancer, with particularly notable results among patients with bone metastases. These results were presented at the 2011 annual meeting of the American Society of Clinical Oncology.. Prostate cancer is a hormonally sensitive disease that can be controlled for long periods with androgen deprivation therapy (ADT). When prostate cancer stops responding to this treatment is it referred to as hormone-refractory prostate cancer. Advances have been made in the treatment of hormone-refractory cancer, but challenges remain and new drugs continue to be developed.. Cabozantinib is an investigational drug that targets two proteins-MET and VEGFR2-that play a role in the development and progression of many types of cancer.. To evaluate cabozantinib in the treatment of hormone-refractory, metastatic prostate cancer, researchers conducted a Phase II clinical trial among 171 patients with ...
of prostate cancer. When this compound was administered to ovariectomized mature female rats for 2 months researchers found it increased BMD and the biomechanical strength of cortical bone in the femur. These findings show that the effects of S-40503 on bone is applicable to both males and females. Rats treated with only estrogen a hormone used to prevent or minimize bone breakdown (resorption) did not positively affect BMD or cortical bone strength.. Please select the Card Type. Please enter a Security Code. LastName is required field.. When Cardarine is administered in excessively high doses in rats over a relatively long period of time the compound may cause cancer. SARMs and AASs. In the Mk-2866 Phytochemical Selective Androgen Receptor Modulator fitness community this compound is most commonly used to improve exercise endurance and assist in fat loss.. Exact Mass: 338. Molecular Weight: 338. Elemental Analysis: C 49. Shipped under ambient temperature as non-hazardous chemical. This product ...
Sumanta Pal, MD of City of Hope, Duarte, CA, discusses the introduction of new data of the new single-agent cabozantinib for advanced renal cell carcinoma. The agent is a dual MET and VEGFR2 inhibitor, and has been assessed in metastatic renal cell carcinoma and other diseases. Dr Pal highlights his involvement in the Phase I trials of cabozantinibs development in renal cell carcinoma, where impressive responses were observed. He proceeds to highlight that most recently, cabozantinib was used in a Phase III METEOR trial comparing it to the agent everolimus (NCT01865747). This study identified an improvement in response rate, overall survival (OS) and progression-free survival (PFS) for patients with advanced renal cell carcinoma. According to Dr Pal, these findings make the agent the optimal second-line choice in patients with metastatic renal cell carcinoma. He further adds that data from the CABOSUN study (NCT01835158), a clinical trial that compared sunitinib and cabozantinib in the front-line
Doping control authorities and sports drug testing laboratories are frequently confronted with the illicit use of performance-enhancing therapeutics and therefore various analytical strategies have been developed to detect a misused drug and/or its metabolic product(s) in blood or urine specimens. Besides the administration of clinically approved drugs prohibited in sports,
TY - JOUR. T1 - Drug Insight. T2 - Testosterone and selective androgen receptor modulators as anabolic therapies for chronic illness and aging. AU - Bhasin, Shalender. AU - Calof, Olga M.. AU - Storer, Thomas W.. AU - Lee, Martin L.. AU - Mazer, Norman A.. AU - Jasuja, Ravi. AU - Montori, Victor Manuel. AU - Gao, Wenqing. AU - Dalton, James T.. PY - 2006/3. Y1 - 2006/3. N2 - Several regulatory concerns have hindered development of androgens as anabolic therapies, despite unequivocal evidence that testosterone supplementation increases muscle mass and strength in men; it induces hypertrophy of type I and II muscle fibers, and increases myonuclear and satellite cell number. Androgens promote differentiation of mesenchymal multipotent cells into the myogenic lineage and inhibit their adipogenic differentiation, by facilitating association of androgen receptors with β-catenin and activating T-cell factor 4. Meta-analyses indicate that testosterone supplementation increases fat-free mass and muscle ...

pMe-anilide anionpMe-anilide anion

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=B670&Units=CAL&Mask=40

pMe-anilide anionpMe-anilide anion

The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
more infohttps://webbook.nist.gov/cgi/cbook.cgi?ID=B670

Medical Subject Headings - Anilides - Classes | NCBO BioPortalMedical Subject Headings - Anilides - Classes | NCBO BioPortal

The National Center for Biomedical Ontology was founded as one of the National Centers for Biomedical Computing, supported by the NHGRI, the NHLBI, and the NIH Common Fund under grant U54-HG004028 ...
more infohttp://bioportal.bioontology.org/ontologies/MESH?p=classes&conceptid=http%3A%2F%2Fpurl.bioontology.org%2Fontology%2FMESH%2FD000813

Ferrocene-based anilides: synthesis, structural characterization and inhibition of butyrylcholinesterase - Dalton Transactions ...Ferrocene-based anilides: synthesis, structural characterization and inhibition of butyrylcholinesterase - Dalton Transactions ...

Twenty-three compounds in two series of ferrocene-based anilides, with the general formula C5H5-Fe-C5H4-C6H4-NH-CO-C6H4-R ( ... Twenty-three compounds in two series of ferrocene-based anilides, with the general formula C5H5-Fe-C5H4-C6H4-NH-CO-C6H4-R ( ... Ferrocene-based anilides: synthesis, structural characterization and inhibition of butyrylcholinesterase A. A. Altaf, M. ...
more infohttps://pubs.rsc.org/en/content/articlelanding/2018/dt/c8dt01726c

Poly (N-Alkyl-O-Nitro Anilides)Poly (N-Alkyl-O-Nitro Anilides)

... IP.com Disclosure Number: IPCOM000051651D Original Publication Date: 1981-Feb-01 Included in ...
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Hydractinia echinata test system. II. SAR toxicity study of some anilide derivatives of Naphthol-AS typeHydractinia echinata test system. II. SAR toxicity study of some anilide derivatives of Naphthol-AS type

SAR toxicity study of some anilide derivatives of Naphthol-AS type. Domenii publicaţii > Chimie + Tipuri publicaţii > Articol ... In this paper, a toxicity study for a series of anilides of Naphthol-AS type is presented. The toxicity of the model compounds ...
more infohttp://ad-astra.ro/2011/07/01/hydractinia-echinata-test-system-ii-sar-toxicity-study-of-some-anilide-derivatives-of-naphthol-as-type/

Binding of Anilide-type Local Anesthetics in Human Plasma:I. Relationships between Binding, Physicochemical Properties, and...Binding of Anilide-type Local Anesthetics in Human Plasma:I. Relationships between Binding, Physicochemical Properties, and...

Binding of Anilide-type Local Anesthetics in Human Plasma: I. Relationships between Binding, Physicochemical Properties, and ... Binding of Anilide-type Local Anesthetics in Human Plasma: I. Relationships between Binding, Physicochemical Properties, and ... Binding of Anilide-type Local Anesthetics in Human Plasma: I. Relationships between Binding, Physicochemical Properties, and ... Geoffrey T. Tucker, Robert N. Boyes, Phillip O. Bridenbaugh, Daniel C. Moore; Binding of Anilide-type Local Anesthetics in ...
more infohttp://anesthesiology.pubs.asahq.org/article.aspx?articleid=1963404

Anilide synonyms, anilide antonyms - FreeThesaurus.comAnilide synonyms, anilide antonyms - FreeThesaurus.com

Antonyms for anilide. 3 synonyms for aniline: aminobenzine, aniline oil, phenylamine. What are synonyms for anilide? ... redirected from anilide). Also found in: Dictionary, Medical, Encyclopedia.. Related to anilide: acetanilide #vtZoom,.vt-link{ ... Strain-dependent cytokine profile and susceptibility to oleic acid anilide in murine model of the toxic oil syndrome.. ... Chemically, the new compounds can be described as anilide derivatives of 8-phenyxanthines and are structurally related to ...
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Countercation effect on CO<sub>2</sub> binding to oxo titanate with bulky anilide...Countercation effect on CO<sub>2</sub> binding to oxo titanate with bulky anilide...

Countercation effect on CO2 binding to oxo titanate with bulky anilide ligands. Albert Paparo, Jared S. Silvia, Thomas P. ... Countercation effect on CO2 binding to oxo titanate with bulky anilide ligands. / Paparo, Albert; Silvia, Jared S.; Spaniol, ... Countercation effect on CO2 binding to oxo titanate with bulky anilide ligands. Chemistry - A European Journal. 2018 Nov 16;24( ... This work focuses on nucleophilic activation of CO2 at the anionic terminal oxo titanium tris(anilide) complexes [(Solv)nM][OTi ...
more infohttps://research.monash.edu/en/publications/countercation-effect-on-cosub2subbinding-to-oxo-titanate-with-bul

Mucinex Fast-Max Severe Cold  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | The Medicine ShoppeMucinex Fast-Max Severe Cold - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | The Medicine Shoppe

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ATC code N02ATC code N02

N02BE Anilides. N02BE01 Paracetamol N02BE03 Phenacetin N02BE04 Bucetin N02BE05 Propacetamol N02BE51 Paracetamol, combinations ...
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Roxicet  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiRoxicet - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Roxicet is a brand name medication included in a group of medications called Anilides. For more information about Roxicet see ...
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Dayquil Cold & Flu  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiDayquil Cold & Flu - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

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Apacet  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiApacet - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

Apacet is a brand name medication included in a group of medications called Anilides. For more information about Apacet see its ...
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Mucinex Fast-Max Cold, Flu and Sore Throat  - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiMucinex Fast-Max Cold, Flu and Sore Throat - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

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Catalysis & biocatalysis in OBC HomeCatalysis & biocatalysis in OBC Home

Cobalt(II)-catalyzed regioselective C-H halogenation of anilides Ze-lin Li, Kang-kang Sun and Chun Cai ...
more infohttp://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=ob&themeid=0b041f09-607b-4b5e-b7be-626c22dcdb60

Search | The Merck Index OnlineSearch | The Merck Index Online

The Merck Index* Online - search across all of the entries using text (names, classifications) and numerical (melting point, mol weight, boiling point) queries
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Silylating Reagents for GC-MS Compatible Derivatives of NSAIDs | Sigma-AldrichSilylating Reagents for GC-MS Compatible Derivatives of NSAIDs | Sigma-Aldrich

Anilides. Although the anilides do not properly belong to the NSAIDs since they do not have an acidic group, they are normally ...
more infohttps://www.sigmaaldrich.com/technical-documents/articles/analytix/silylation-reagents.html

Patent US8156718 - Method of preparing a packaged antimicrobial medical device - Google PatentsPatent US8156718 - Method of preparing a packaged antimicrobial medical device - Google Patents

... anilides such as triclorocarbanilide; biguanides such as chlorhexidine; chlorine-releasing agents such as sodium hypochlorite, ...
more infohttp://www.google.com/patents/US8156718?dq=6377161

Patent US5693330 - Skin care compositions containing melinamide and a retinoid - Google PatentsPatent US5693330 - Skin care compositions containing melinamide and a retinoid - Google Patents

Carboxamides and anilides. US5308551 *. 3 Sep 1991. 3 May 1994. Loreal. Washing compositions based on silicones and process of ...
more infohttp://www.google.com.au/patents/US5693330

Hydrocodone/paracetamol - WikipediaHydrocodone/paracetamol - Wikipedia

Anilide analgesic. Clinical data. Trade names. Lorcet, Norco, Vicodin, others. Synonyms. Hydrocodone/acetaminophen, hydrocodone ...
more infohttps://en.wikipedia.org/wiki/Vicodin

Patent US4990939 - Bubble jet printer head with improved operational speed - Google PatentsPatent US4990939 - Bubble jet printer head with improved operational speed - Google Patents

b) Insoluble azo-pigments (anilides):. Diazo Yellow, Fast Yellow, G. Fast Yellow 100, Diazo Orange, Vulcan Orange, Ryrazolon ...
more infohttp://www.google.com/patents/US4990939?dq=6016038

O-aminosulfonylglycolic amides - BASF AktiengesellschaftO-aminosulfonylglycolic amides - BASF Aktiengesellschaft

Substituted sulfonylglycolic acid anilides. 1975-02-11. Rohr et al.. 260/456A. ... Substituted O-(aminosulfonyl)-glycolic anilides. 1975-03-11. Fischer et al.. 260/456A. ... Ix o-(isopropylaminosulfonyl)-glycolic acid-N-butyn-1-yl-3-anilide (comparative agent). ... glycolic acid-N-butyn-1-yl anilide (German Laid-Open Application DOS 2,201,432) as selective herbicides in various crops is ...
more infohttp://www.freepatentsonline.com/4009192.html

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  • 1999), 13 weeks of exposure of 4-week-old rats to 3,3',4,4'-tetrachloroazoxybenzene, a contaminant of 3,4-dichloroaniline and the anilide herbicide Diuron, which acts through the aryl hydrocarbon receptor in a dioxin-like manner, decreased the motility but not the concentration of the epididymal spermatozoa. (freethesaurus.com)
  • Strain-dependent cytokine profile and susceptibility to oleic acid anilide in murine model of the toxic oil syndrome. (freethesaurus.com)
  • The use of N,N-diallyl-2-chloroacetamide (German Printed Application DAS 1,014,380) and O-(isopropylaminosulfonyl)-glycolic acid-N-butyn-1-yl anilide (German Laid-Open Application DOS 2,201,432) as selective herbicides in various crops is known. (freepatentsonline.com)
  • Twenty-three compounds in two series of ferrocene-based anilides, with the general formula C 5 H 5 -Fe-C 5 H 4 -C 6 H 4 -NH-CO-C 6 H 4 -R (where R = H, F, Cl, CH 3 and OCH 3 ), have been successfully synthesized. (rsc.org)
  • Roxicet is a brand name medication included in a group of medications called Anilides . (rxwiki.com)
  • Vitapap is a brand name medication included in a group of medications called Anilides . (rxwiki.com)
  • An anilide resulting from the formal condensation of the aryl amino group of 4-(methoxymethyl)-N-phenyl-1-[2-(2-thienyl)ethyl]piperidin-4-amine with propanoic acid. (mcw.edu)
  • The most potent inhibitor is an anilide derived from 2-chloro-4-nitroaniline, l-phenylalanine and 4-(dimethylamino)benzoic acid. (scripps.edu)
  • A diversified library of peptide anilides was prepared, and their inhibition activities against the SARS-CoV 3CL protease were examined by a fluorogenic tetradecapeptide substrate. (scripps.edu)